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["Accession","Description","Coverage [%]","# Peptides","# PSMs","# Unique Peptides","# AAs","MW [kDa]","calc. pI","Score Sequest HT: Sequest HT","Biological Process","Cellular Component","Molecular Function","Gene Symbol","Ensembl Gene ID","KEGG Pathways","Reactome Pathways","WikiPathways","Abundance Ratio: (ARV) / (DMSO)","Abundance Ratio: (CF3-P) / (DMSO)","Abundance Ratio: (Cl-P) / (DMSO)","Abundance Ratio: (F-P) / (DMSO)","Abundance Ratio: (Le-P) / (DMSO)","Abundances (Grouped): ARV","Abundances (Grouped): CF3-P","Abundances (Grouped): Cl-P","Abundances (Grouped): DMSO","Abundances (Grouped): F-P","Abundances (Grouped): Le-P","Abundances (Scaled): F7: 127N, Sample, ARV","Abundances (Scaled): F7: 128N, Sample, ARV","Abundances (Scaled): F7: 129N, Sample, ARV","Abundances (Scaled): F7: 133N, Sample, CF3-P","Abundances (Scaled): F7: 134N, Sample, CF3-P","Abundances (Scaled): F7: 135N, Sample, CF3-P","Abundances (Scaled): F7: 132C, Sample, Cl-P","Abundances (Scaled): F7: 133C, Sample, Cl-P","Abundances (Scaled): F7: 134C, Sample, Cl-P","Abundances (Scaled): F7: 126, Sample, DMSO","Abundances (Scaled): F7: 127C, Sample, DMSO","Abundances (Scaled): F7: 128C, Sample, DMSO","Abundances (Scaled): F7: 130N, Sample, F-P","Abundances (Scaled): F7: 131N, Sample, F-P","Abundances (Scaled): F7: 132N, Sample, F-P","Abundances (Scaled): F7: 129C, Sample, Le-P","Abundances (Scaled): F7: 130C, Sample, Le-P","Abundances (Scaled): F7: 131C, Sample, Le-P","Abundances (Normalized): F7: 127N, Sample, ARV","Abundances (Normalized): F7: 128N, Sample, ARV","Abundances (Normalized): F7: 129N, Sample, ARV","Abundances (Normalized): F7: 133N, Sample, CF3-P","Abundances (Normalized): F7: 134N, Sample, CF3-P","Abundances (Normalized): F7: 135N, Sample, CF3-P","Abundances (Normalized): F7: 132C, Sample, Cl-P","Abundances (Normalized): F7: 133C, Sample, Cl-P","Abundances (Normalized): F7: 134C, Sample, Cl-P","Abundances (Normalized): F7: 126, Sample, DMSO","Abundances (Normalized): F7: 127C, Sample, DMSO","Abundances (Normalized): F7: 128C, Sample, DMSO","Abundances (Normalized): F7: 130N, Sample, F-P","Abundances (Normalized): F7: 131N, Sample, F-P","Abundances (Normalized): F7: 132N, Sample, F-P","Abundances (Normalized): F7: 129C, Sample, Le-P","Abundances (Normalized): F7: 130C, Sample, Le-P","Abundances (Normalized): F7: 131C, Sample, Le-P","Found in Sample: [S2] F7: 127N, Sample, ARV","Found in Sample: [S4] F7: 128N, Sample, ARV","Found in Sample: [S6] F7: 129N, Sample, ARV","Found in Sample: [S14] F7: 133N, Sample, CF3-P","Found in Sample: [S16] F7: 134N, Sample, CF3-P","Found in Sample: [S18] F7: 135N, Sample, CF3-P","Found in Sample: [S13] F7: 132C, Sample, Cl-P","Found in Sample: [S15] F7: 133C, Sample, Cl-P","Found in Sample: [S17] F7: 134C, Sample, Cl-P","Found in Sample: [S1] F7: 126, Sample, DMSO","Found in Sample: [S3] F7: 127C, Sample, DMSO","Found in Sample: [S5] F7: 128C, Sample, DMSO","Found in Sample: [S8] F7: 130N, Sample, F-P","Found in Sample: [S10] F7: 131N, Sample, F-P","Found in Sample: [S12] F7: 132N, Sample, F-P","Found in Sample: [S7] F7: 129C, Sample, Le-P","Found in Sample: [S9] F7: 130C, Sample, Le-P","Found in Sample: [S11] F7: 131C, Sample, Le-P"]
["O60885-1","Bromodomain-containing protein 4 [OS=Homo sapiens]",4,5,6,5,1362,152.1,9.19,12.26,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","kinase activity;other molecular function","BRD4","ENSG00000141867; ENSPTRG00000010619","","Potential therapeutics for SARS","VEGFA-VEGFR2 signaling pathway; 7q11.23 copy number variation syndrome",0.143,0.161,0.154,0.148,0.138,49.3,55.4,53,344,51,47.3,52.8,52.7,58.1,59.4,68.3,58.7,56.8,62.5,55.8,368.7,374.2,219.9,55.4,54.6,53.1,50.7,51.3,46.9,308.1,307.5,338.7,346.2,398.3,342.2,331,364.5,325.6,2149.6,2182.1,1282.2,323,318.6,309.7,295.8,299.1,273.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P35556","Fibrillin-2 [OS=Homo sapiens]",0,1,1,1,2912,314.6,4.86,0,"developmental processes;other biological processes","non-structural extracellular;extracellular matrix","extracellular structural activity;other molecular function","FBN2","ENSG00000138829","","Degradation of the extracellular matrix; Molecules associated with elastic fibres","Hypothesized pathways in pathogenesis of cardiovascular disease",0.174,0.198,0.21,0.311,0.145,51.2,58.3,61.7,294.4,91.7,42.7,118.4,47.2,45.4,53.7,99.9,46.8,135,56.9,44.3,271.4,116.9,271.4,84.5,145.4,59.2,36.3,39.4,127.8,62.1,24.8,23.8,28.2,52.4,24.5,70.8,29.8,23.2,142.3,61.3,142.3,44.3,76.3,31.1,19.1,20.6,67,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UKT9-1","Zinc finger protein Aiolos [OS=Homo sapiens]",20,9,21,6,509,58,6.55,65.67,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","IKZF3","ENSG00000161405","","","",0.178,0.563,0.542,0.512,0.46,32.8,103.8,99.9,184.4,94.3,84.8,30.6,33.9,35,107.4,107.9,101,103.3,104.6,99.8,193.6,190.7,133.7,102.2,97.6,96.3,87.8,87.8,86.8,509.2,564.6,582.5,1789.5,1797.1,1683.2,1721.9,1742.9,1663.3,3226.4,3177.3,2227.4,1703.5,1625.6,1604.1,1462,1462.6,1446.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P29692-3","Isoform 3 of Elongation factor 1-delta [OS=Homo sapiens]",75,15,142,1,257,28.5,4.92,481.76,"","","","EEF1D","","","","",0.193,0.258,0.264,0.208,0.233,53.7,71.8,73.4,278.3,57.9,64.8,32.9,22.9,25.8,31.8,57.4,34.4,43.7,35.2,31.1,133.5,30,1152.7,27.8,38.8,22.3,16.3,31.1,32.1,18.7,13,14.6,18.1,32.6,19.6,24.8,20,17.7,75.9,17,654.8,15.8,22.1,12.7,9.3,17.7,18.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96QD8","sodium-coupled neutral amino acid transporter 2 [OS=Homo sapiens]",4,1,4,1,506,56,8,20.51,"stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","transporter activity","SLC38A2","ENSG00000134294","Glutamatergic synapse; GABAergic synapse; Protein digestion and absorption","Glutamate Neurotransmitter Release Cycle; Amino acid transport across the plasma membrane","Endochondral ossification; Endochondral ossification with skeletal dysplasias; Neuroinflammation and glutamatergic signaling",0.205,0.271,0.236,0.231,0.231,56.5,74.9,65.2,276,63.8,63.7,46.9,48.1,44.3,62.1,67,58.6,57.4,54.1,49.1,229.1,225,525.6,65.6,49.1,52.9,52.9,49.7,62.4,69.9,71.6,66.1,92.6,99.8,87.3,85.6,80.6,73.2,341.4,335.3,783.2,97.8,73.2,78.9,78.8,74.1,93,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q13572-1","Inositol-tetrakisphosphate 1-kinase [OS=Homo sapiens]",2,1,4,1,414,45.6,6.16,2.08,"other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","kinase activity;other molecular function","ITPK1","ENSG00000100605; ENSG00000274958","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Factors involved in megakaryocyte development and platelet production; Synthesis of IP3 and IP4 in the cytosol; Synthesis of pyrophosphates in the cytosol","",0.208,0.263,0.233,0.233,0.243,57.1,72.3,64.2,275.3,64.1,67,10.4,4.5,11,13.2,39.3,11.1,11.7,12.3,10.9,50.1,6.2,1556.8,11.7,11.7,13.1,1.1,12.8,12.2,115.7,50.5,122.2,146.4,437.1,123.9,130.1,136.3,121.1,557.5,69.4,17315.6,129.8,129.8,145.4,12.5,142,135.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P25440-1","Bromodomain-containing protein 2 [OS=Homo sapiens]",3,2,2,2,801,88,9.09,5.99,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","kinase activity;other molecular function","BRD2","ENSG00000204256; ENSG00000215077; ENSG00000234507; ENSG00000234704; ENSG00000235307; ENSGGOG00000043461","","RUNX3 regulates p14-ARF","",0.226,0.245,0.224,0.217,0.202,64.2,69.5,63.7,283.9,61.6,57.2,66.7,77.1,68.2,73.9,77.2,68,73.1,67.7,65.1,301.8,309.8,166.9,64.1,65.5,73,60.8,65.2,55.8,150.2,173.6,153.5,166.3,173.8,153.1,164.5,152.4,146.5,679.3,697.2,375.8,144.3,147.4,164.2,136.9,146.8,125.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P15531","Nucleoside diphosphate kinase A [OS=Homo sapiens]",86,10,154,2,152,17.1,6.19,461.69,"DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","cytoskeletal activity;translation activity;nucleic acid binding activity;kinase activity;other molecular function","NME1","ENSG00000239672","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors","Interconversion of nucleotide di- and triphosphates","Pyrimidine metabolism",0.235,0.21,0.247,0.246,0.23,65,58.1,68.5,276.8,68,63.6,71.3,53.9,54.6,48.8,159.5,48.5,98.4,57.5,48.1,232.4,61.7,485,57.1,71.8,55.7,53,53.4,89.4,281.5,212.6,215.5,192.7,629.7,191.6,388.3,226.9,189.9,917.5,243.4,1914.7,225.4,283.6,219.8,209.1,210.8,352.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q71UM5","40S ribosomal protein S27-like [OS=Homo sapiens]",39,4,17,2,84,9.5,9.45,45.97,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;translational apparatus;nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","RPS27L","ENSG00000185088","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","",0.26,0.264,0.295,0.289,0.242,66.3,67.3,75.3,255.5,73.8,61.8,72.8,43.7,48.1,46,85.1,48.8,84.5,54.5,45.6,185.1,80.9,669.7,48.7,79.4,53.4,38.2,44.8,70.6,418,250.7,275.9,264.1,488.6,280,484.9,313.1,261.5,1062.4,464.4,3844.4,279.6,456,306.8,219.5,257.1,405.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["A0A096LP01","Small integral membrane protein 26 [OS=Homo sapiens]",17,1,1,1,95,10.9,6.7,3.05,"","other membranes","","SMIM26","ENSG00000232388","","","",0.264,0.306,0.234,0.191,0.21,71.9,83.2,63.6,272.2,52,57.1,73.4,85.9,78.7,91.2,91,87.3,69.6,59.8,73.3,297.8,333.5,101.1,56.9,58.9,56.6,58.5,62.5,64,62,72.5,66.4,77,76.8,73.7,58.7,50.4,61.9,251.3,281.5,85.3,48,49.7,47.7,49.4,52.7,54,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O95503","Chromobox protein homolog 6 [OS=Homo sapiens]",2,1,1,1,412,43.9,10.01,2.47,"cell organization and biogenesis;other biological processes","nucleus;other cell component","","CBX6","ENSG00000183741","","Regulation of PTEN gene transcription; Oxidative Stress Induced Senescence; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","",0.282,0.34,0.239,0.211,0.25,72.8,87.8,61.8,258.5,54.6,64.6,67.6,75.3,81.9,77.2,90.8,100.6,64,61.5,69.2,267.5,283.5,208.4,56.8,56.5,53.3,67.5,66.8,51.7,63.3,70.5,76.7,72.2,85.1,94.2,59.9,57.6,64.8,250.5,265.5,195.1,53.2,52.9,49.9,63.3,62.6,48.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96MG7","Non-structural maintenance of chromosomes element 3 homolog [OS=Homo sapiens]",11,2,2,2,304,34.3,9.28,5.62,"DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","other molecular function","NSMCE3","ENSG00000185115; ENSG00000282130","","SUMOylation of DNA damage response and repair proteins","",0.283,0.334,0.339,0.354,0.345,63.9,75.5,76.6,225.9,80.1,77.9,33.7,31.2,31.9,34.8,151.3,37.7,59.7,33.6,38.2,112.7,25.9,958.8,39.8,39.9,42.6,23.3,38.9,65.9,80.8,74.8,76.6,83.7,363.3,90.4,143.3,80.7,91.7,270.6,62.3,2301.8,95.5,95.9,102.3,56,93.3,158.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P14151","L-selectin [OS=Homo sapiens]",2,1,2,1,372,42.2,6.6,2.11,"cell adhesion","plasma membrane;other membranes","other molecular function","SELL","ENSG00000188404","Cell adhesion molecules","Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall","Complement system",0.285,0.365,0.402,0.393,0.348,61.3,78.5,86.3,214.8,84.5,74.7,48.4,56.9,50.9,62.8,193.3,65.2,121.6,71.7,52.1,178.5,79.7,400.5,77.6,70.2,53.7,62.1,52.6,101.9,109.2,128.3,114.9,141.7,436.1,147.2,274.2,161.8,117.6,402.7,179.8,903.4,175,158.4,121.2,140.1,118.7,229.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NSD4","zinc finger protein 275 [OS=Homo sapiens]",3,1,1,1,429,48.4,9.09,2.04,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF275","ENSG00000063587","","","",0.326,0.461,0.328,0.341,0.306,70.9,100.1,71.2,217.3,74,66.4,71.4,67.1,78.2,100.9,115.5,96.2,91.1,71.8,69.9,218.9,219.8,180.2,69.9,78.8,74.5,59.8,69.1,66.9,89.8,84.4,98.2,126.8,145.1,121,114.4,90.2,87.9,275.1,276.2,226.4,87.8,99,93.7,75.1,86.9,84.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q02223","tumor necrosis factor receptor superfamily member 17 [OS=Homo sapiens]",24,3,5,3,184,20.2,5.35,9.22,"developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","TNFRSF17","ENSG00000048462","Cytokine-cytokine receptor interaction; Intestinal immune network for IgA production","TNFs bind their physiological receptors","Genotoxicity pathway",0.334,0.325,0.331,0.366,0.354,73.8,72,73.3,221.4,81.1,78.3,69.5,78,78.1,81.4,62.9,76,73.8,77.5,87.7,233.9,286.5,90.7,83.9,89.9,85.7,84.4,82.8,77.3,232.1,260.6,260.9,272,210.2,254,246.5,258.9,293,781.4,956.9,303.1,280.1,300.3,286.3,282,276.5,258.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6PI26","Protein SHQ1 homolog [OS=Homo sapiens]",4,1,1,1,577,65.1,4.79,3.69,"cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","other molecular function","SHQ1","ENSG00000144736","","Telomere Extension By Telomerase","",0.338,0.294,0.343,0.274,0.35,78,68,79.2,230.9,63.2,80.7,70,79.2,82.9,58.8,69.1,91.3,80.5,90.7,60.3,169,237.8,234.5,93.6,64.2,59.7,81,82,95.5,15.1,17.1,17.9,12.7,14.9,19.7,17.4,19.6,13,36.5,51.3,50.6,20.2,13.8,12.9,17.5,17.7,20.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q5JTD0-1","Tight junction-associated protein 1 [OS=Homo sapiens]",15,7,9,7,557,61.8,5.97,21.96,"cell organization and biogenesis","plasma membrane;other membranes;ER/Golgi;other cell component","","TJAP1","ENSG00000137221","Tight junction","","",0.343,0.417,0.354,0.359,0.391,71.8,87.3,74.2,209.6,75.2,81.9,42.6,43.4,49,38.9,148,52.8,66.5,42.3,44.9,126.8,57.7,818.1,46.3,34.3,45.5,35.6,49.5,57.7,709.6,723.1,815.6,647.7,2463.8,879.5,1107.6,704,747.5,2110.3,960.5,13621.1,770.4,571,757,592.9,824.6,961.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BVJ6-1","U3 small nucleolar RNA-associated protein 14 homolog A [OS=Homo sapiens]",19,13,21,13,771,87.9,7.87,65.55,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","","UTP14A","ENSG00000156697","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",0.349,0.4,0.324,0.317,0.291,78.2,89.5,72.5,223.8,70.9,65.1,75.1,77.8,76.4,89.4,87.4,87,70.4,70.8,71.6,218.4,218.8,249.2,76.4,68.3,69.3,61.6,68.3,63.7,982.1,1018.2,999.5,1170,1144.2,1138.7,921.2,927,937.3,2857.9,2862.7,3260.5,999.6,894.3,907.1,806.5,893.3,833,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y2Y9","Krueppel-like factor 13 [OS=Homo sapiens]",9,2,2,1,288,31.2,9.54,6.01,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KLF13","ENSG00000169926; ENSG00000275746","","","15q13.3 copy number variation syndrome",0.355,0.529,0.42,0.371,0.392,69.4,103.4,82.2,195.6,72.6,76.7,62.2,68,86.9,101.3,109.4,89.5,95,80.5,66.2,189.5,191.6,219.6,66.4,84.8,71.1,67.8,75.2,75.1,64,70,89.3,104.2,112.5,92.1,97.7,82.8,68.1,195,197.1,225.9,68.3,87.2,73.1,69.8,77.3,77.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q01105-2","Isoform 2 of Protein SET [OS=Homo sapiens]",59,17,238,3,277,32.1,4.22,778.78,"","","","SET","","","","",0.356,0.306,0.325,0.376,0.316,79.7,68.5,72.8,224,84.2,70.8,94.3,64.2,72.8,62.6,118.8,59.3,96.5,66.5,63.5,204.6,99.8,362,76.9,80.7,68.7,59.9,64.7,84.2,843.8,574.8,651.9,560.2,1063.3,530.6,864.1,595.2,568.1,1831.6,893.7,3240.4,688.3,722.7,615.1,536.2,578.8,753.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O75362","zinc finger protein 217 [OS=Homo sapiens]",5,5,5,4,1048,115.2,8.48,14.96,"other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","ZNF217","ENSG00000171940","","Estrogen-dependent gene expression","",0.372,0.425,0.349,0.316,0.298,80.8,92.4,75.8,217.4,68.8,64.8,78.2,85.2,88.5,103.3,78.1,97.4,73.5,79.9,84.9,229.1,267.5,108.8,72.5,75.5,72.2,67.8,69.4,68.3,232,252.8,262.7,306.4,231.8,289,218.1,237.1,252,679.9,793.7,323,215.1,223.9,214.2,201.1,205.9,202.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H6F5","Coiled-coil domain-containing protein 86 [OS=Homo sapiens]",28,8,11,8,360,40.2,10.33,30.05,"","nucleus;other cell component","","CCDC86","ENSG00000110104","","","",0.373,0.611,0.857,0.897,0.458,53.3,87.4,122.5,143,128.3,65.5,51.4,48.1,127.5,93.5,84.2,65.8,118,118.8,90.7,137.7,73.9,190.4,130.4,99.8,123.5,128.5,63.1,54.7,595.9,558.6,1479.4,1084.5,976.9,763.5,1369,1378.6,1052.3,1597.6,858,2210.1,1513.8,1157.6,1433.6,1491.7,732.3,635,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8N4A0","polypeptide N-acetylgalactosaminyltransferase 4 [OS=Homo sapiens]",4,2,9,1,578,66.6,7.61,24.58,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","GALNT4","ENSG00000257594","Mucin type O-glycan biosynthesis; Other types of O-glycan biosynthesis; Metabolic pathways","O-linked glycosylation of mucins","",0.378,0.415,0.426,0.402,0.381,75.5,83,85.2,199.9,80.4,76.1,66.4,62.5,55.7,68.8,129.1,59.3,86.2,70.6,65.8,165.7,95.9,472.2,50.3,76.2,66.6,63.1,60.1,85.6,41.1,38.7,34.5,42.5,79.9,36.7,53.3,43.7,40.7,102.5,59.3,292.1,31.1,47.1,41.2,39,37.1,52.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q66K64","DDB1- and CUL4-associated factor 15 [OS=Homo sapiens]",2,1,1,1,600,66.4,6.58,0,"protein metabolism;other metabolic processes;other biological processes","other cell component","other molecular function","DCAF15","ENSG00000132017; ENSG00000288453","","","",0.384,0.621,0.489,0.49,0.57,64.8,104.8,82.5,168.8,82.7,96.3,66,68.4,93.7,110.5,113.8,104.2,101.8,87,86.9,178.1,262.5,8,87.2,74.1,90,101.6,61,105.1,8.3,8.6,11.8,13.9,14.3,13.1,12.8,11,11,22.4,33.1,1,11,9.3,11.3,12.8,7.7,13.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96JP5-1","E3 ubiquitin-protein ligase ZFP91 [OS=Homo sapiens]",14,6,13,6,570,63.4,7.36,36.09,"protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus","other molecular function","ZFP91","ENSG00000186660","","","",0.384,0.808,0.79,0.849,0.753,50.3,105.7,103.4,130.9,111.1,98.6,46.6,50.1,50.2,108.3,105.2,104.8,109.9,102.9,101.5,127.8,130.3,134.4,111.3,107.8,110.6,104.4,95.9,98.1,420.4,451.6,453,976.7,949.4,945.2,991.5,928.4,916.2,1153.1,1175.6,1212.2,1004,972.7,998,942,865.2,885.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NYP9","protein Mis18-alpha [OS=Homo sapiens]",14,2,2,2,233,25.8,5.2,2.73,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","other molecular function","MIS18A","ENSG00000159055","","Deposition of new CENPA-containing nucleosomes at the centromere","",0.393,0.485,0.405,0.537,0.516,70.7,87.3,72.9,179.8,96.6,92.7,67.5,79.3,68.1,95.8,65.6,84.1,79.7,52.3,70.2,141.4,173.3,275.9,105.7,93.1,86.2,76.9,89.4,95.3,22.4,26.3,22.6,31.8,21.7,27.9,26.4,17.3,23.3,46.9,57.5,91.5,35.1,30.9,28.6,25.5,29.6,31.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P15923-2","Isoform E47 of Transcription factor E2-alpha [OS=Homo sapiens]",7,4,6,4,651,67.2,6.71,14.28,"","","","TCF3","","","","",0.4,0.45,0.424,0.473,0.461,74.9,84.2,79.2,187,88.5,86.1,77.5,72.5,75.4,84.8,87.5,78,79.7,90.8,76.1,175.8,190.5,188.2,85.2,89.1,90.2,89.7,86.7,82.4,193.8,181.5,188.6,212.1,218.8,195.3,199.5,227.2,190.3,439.9,476.7,470.9,213.2,222.9,225.6,224.4,216.9,206.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y3A4","Ribosomal RNA-processing protein 7 homolog A [OS=Homo sapiens]",21,5,9,5,280,32.3,9.58,22.92,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","","RRP7A","ENSG00000189306","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",0.401,0.403,0.403,0.367,0.407,80.8,81,81.1,201.3,73.8,81.9,80,83.1,87.2,83.3,82.8,91,78,83.3,84,212.3,206.9,151.5,82.6,75.3,75.9,84.1,87.4,71.3,887.4,920.7,967,923,917.4,1009.4,864.2,923.5,931.7,2353.5,2293.2,1679.8,916,835.1,841,932.5,969.1,790.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q13422","DNA-binding protein Ikaros [OS=Homo sapiens]",23,10,17,7,519,57.5,6.58,50.14,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","IKZF1","ENSG00000185811","","","Development of pulmonary dendritic cells and macrophage subsets",0.402,0.68,0.68,0.675,0.637,59.2,100.1,100.2,147.3,99.5,93.8,56.9,59.3,58.8,105.4,99.5,98.2,98.8,101.4,99.5,146.3,150.6,141.2,103.6,97.8,98.8,97.4,93.3,93,1014.3,1057.5,1048.1,1879.1,1773,1750.3,1761.4,1807.5,1774,2608.1,2684.2,2516.8,1845.7,1742.3,1761.4,1736.7,1662.2,1657.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96QD9-1","UAP56-interacting factor [OS=Homo sapiens]",5,1,1,1,318,35.8,11.78,2.8,"other metabolic processes;transport","nucleus","nucleic acid binding activity","FYTTD1","ENSG00000122068; ENSPPAG00000027558; ENSPTRG00000015796","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","",0.414,0.589,0.461,0.463,0.45,73.5,104.7,81.9,177.7,82.3,79.9,71.3,100.2,66.5,101.7,76.7,126.5,74.4,122,79.5,196.6,148.9,172.5,79.9,77.8,92.8,77.6,79.5,55.5,11.1,15.6,10.3,15.8,11.9,19.6,11.6,18.9,12.3,30.5,23.1,26.8,12.4,12.1,14.4,12,12.3,8.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9ULJ3","Zinc finger and BTB domain-containing protein 21 [OS=Homo sapiens]",2,3,4,3,1066,118.8,8.29,9.48,"other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","ZBTB21","ENSG00000173276","","","",0.415,0.803,0.766,0.753,0.663,56.5,109.5,104.5,136.4,102.7,90.4,56.2,54.3,58.7,124.3,103.4,108.9,102.4,103.9,108,135.7,145.7,120.1,99.8,102.2,104.1,97,89.9,85.4,245.6,237,256.4,542.9,451.7,475.6,447.2,453.9,471.7,592.5,636.5,524.7,435.7,446.2,454.5,423.8,392.6,373,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O00762","Ubiquitin-conjugating enzyme E2 C [OS=Homo sapiens]",6,1,1,1,179,19.6,7.37,0,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","UBE2C","ENSG00000175063","Ubiquitin mediated proteolysis","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Gastric cancer network 1; Gastric cancer network 2",0.416,0.28,0.325,0.275,0.389,93,62.6,72.7,223.4,61.4,86.9,81.2,87.6,53.2,54.7,52.4,83.5,63.5,58.5,66.9,153.6,195.1,428.6,75.1,52.9,53.6,75.9,99.2,64.4,26.1,28.2,17.1,17.6,16.8,26.9,20.4,18.8,21.5,49.4,62.7,137.8,24.1,17,17.2,24.4,31.9,20.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UFF9","CCR4-NOT transcription complex subunit 8 [OS=Homo sapiens]",4,1,1,1,292,33.5,4.81,2.89,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","CNOT8","ENSG00000155508","RNA degradation","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","",0.417,0.517,0.401,0.35,0.363,82.1,101.8,78.9,196.8,68.9,71.5,88.9,109.3,73.5,95.7,113.7,110.2,85.4,101.1,83.4,213,221.2,48.8,72.2,83.5,74.5,79.2,77.3,69.2,50.9,62.6,42.1,54.8,65.1,63.1,48.9,57.9,47.8,122,126.7,27.9,41.3,47.8,42.7,45.4,44.3,39.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q13895","Bystin [OS=Homo sapiens]",36,14,28,14,437,49.6,8.12,79.11,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","BYSL","ENSG00000112578","","Major pathway of rRNA processing in the nucleolus and cytosol","",0.417,0.46,0.426,0.418,0.417,79.8,87.9,81.5,191.2,79.9,79.7,82,79.2,79.8,87.9,89.6,83.6,80.1,81.5,85,191.2,178.8,202.8,80.8,79.9,77.4,79.7,78.2,82.1,2222.4,2145.4,2162.3,2382.5,2428,2263.8,2171.4,2208,2304.2,5181.3,4845.5,5496,2190,2165.4,2098,2159.7,2119.8,2225.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q15051-1","IQ calmodulin-binding motif-containing protein 1 [OS=Homo sapiens]",2,1,1,1,598,68.9,9.1,2.67,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","IQCB1","ENSG00000173226","","Anchoring of the basal body to the plasma membrane","Ciliary landscape; Ciliopathies",0.419,0.413,0.442,0.483,0.54,76.3,75.1,80.5,182,87.9,98.2,76.5,78.8,68.7,75.4,79,74.8,106.3,80.8,78.4,182.5,185,152.7,84,88.2,93.2,98.5,83.9,113.3,112.8,116.2,101.3,111.2,116.6,110.3,156.7,119.1,115.7,269.2,272.9,225.3,123.8,130.1,137.5,145.4,123.8,167,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8WYQ3","Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial [OS=Homo sapiens]",16,1,2,1,142,14.1,7.84,6.37,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","other membranes;mitochondrion;nucleus","","CHCHD10","ENSG00000250479; ENSG00000273607","Amyotrophic lateral sclerosis","Mitochondrial protein import","",0.421,0.398,0.381,0.419,0.401,83.7,79,75.6,198.7,83.2,79.7,85.8,82.8,84.3,79.6,77.2,94.7,76.1,89.6,66.8,173.8,222,200,83.9,83.8,56.9,91.9,70.7,80.2,24.5,23.7,24.1,22.8,22.1,27.1,21.8,25.6,19.1,49.7,63.5,57.2,24,24,16.3,26.3,20.2,22.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O95478","Ribosome biogenesis protein NSA2 homolog [OS=Homo sapiens]",26,6,10,6,260,30,10.27,28.21,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","NSA2","ENSG00000164346","","","",0.426,0.49,0.415,0.394,0.393,82,94.2,79.9,192.4,75.8,75.7,84.9,79.9,82.1,87.5,98.2,94.3,80,84.2,78.1,192.6,172.2,204.7,75.9,75.7,81.2,74.8,75.8,78,933.6,878.5,902.9,962.7,1079.7,1037.5,879.9,926.2,858.6,2118.4,1893.5,2250.7,834.2,831.9,892.6,822.2,833.1,857.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NRX1","RNA-binding protein pno1 [OS=Homo sapiens]",19,4,8,4,252,27.9,9.73,13.89,"","cytosol;nucleus","","PNO1","ENSG00000115946","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",0.429,0.498,0.451,0.452,0.45,78.4,91.2,82.4,182.9,82.7,82.4,73.4,74.3,76.5,86.3,86.4,73.9,81.3,77.5,78.1,173.2,172.9,285.3,79.7,78.3,72.9,78.2,73.9,78,692.1,700.7,721.3,814.4,815.2,697,767.2,731.4,736.6,1634,1631.3,2691.3,751.5,739,687.5,737.7,697,736,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O14757","Serine/threonine-protein kinase Chk1 [OS=Homo sapiens]",4,2,2,2,476,54.4,8.25,5.21,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","CHEK1","ENSG00000149554","Cell cycle; p53 signaling pathway; Cellular senescence; Human T-cell leukemia virus 1 infection; Human immunodeficiency virus 1 infection; Viral carcinogenesis","Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Transcriptional Regulation by E2F6; Signaling by SCF-KIT; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex","miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; ATR signaling; ATM signaling in development and disease ; DNA repair pathways, full network; DNA damage response",0.433,0.541,0.438,0.46,0.485,77.3,96.7,78.3,178.8,82.1,86.8,81.1,80.5,83,79.1,101.4,103.4,77.7,82.2,88,216.1,187.6,91.8,82.1,88.2,86.2,86.1,91.1,94.4,175.9,174.6,179.9,171.4,219.9,224.2,168.4,178.2,190.8,468.5,406.6,199.1,178,191.3,186.9,186.8,197.4,204.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9ULW3","activator of basal transcription 1 [OS=Homo sapiens]",25,3,3,3,272,31.1,9.88,10.7,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ABT1","ENSG00000146109","","","",0.433,0.39,0.404,0.396,0.361,87,78.5,81.2,201.1,79.6,72.5,80.2,85.4,78,69.7,72.4,91.3,76.1,63.9,74.9,163.9,185.4,340,73.4,65.2,73.6,62.7,77.2,66.8,103.3,109.9,100.3,89.6,93.2,117.5,97.9,82.2,96.4,210.9,238.6,437.5,94.4,83.9,94.7,80.6,99.3,86,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q7Z5L9-1","Interferon regulatory factor 2-binding protein 2 [OS=Homo sapiens]",36,14,22,11,587,61,8.69,94.97,"developmental processes;other biological processes","nucleus;other cell component","other molecular function","IRF2BP2","ENSG00000168264","","","",0.438,0.47,0.444,0.431,0.44,81.5,87.5,82.6,186.2,80.2,82,75.7,76.1,78.2,79,81.8,82,78.8,77.2,75.9,174,165.5,303.2,72.9,74.9,79.9,71.3,76.6,77,1526.7,1535.2,1577.2,1594,1649.1,1653.5,1588.1,1556.4,1530,3508.6,3337,6114.4,1469.8,1511.1,1611.4,1438.5,1545,1553.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NV06","DDB1- and CUL4-associated factor 13 [OS=Homo sapiens]",11,4,4,4,445,51.4,9.19,15.96,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","DCAF13","ENSG00000164934","","Neddylation; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",0.439,0.496,0.415,0.414,0.382,83.7,94.6,79.2,190.7,78.9,72.8,94.9,78,83.8,98.8,88.9,94.7,87.2,79.2,79,191.2,190.9,178.7,76.4,80.2,79,72.9,70.2,76.2,353.8,290.7,312.3,368.3,331.4,353.1,325.2,295.4,294.6,712.8,711.8,666.3,284.7,299,294.5,271.8,261.7,284.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q14692","ribosome biogenesis protein BMS1 homolog [OS=Homo sapiens]",16,16,27,16,1282,145.7,6.44,68.05,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","BMS1","ENSG00000165733","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",0.439,0.454,0.406,0.385,0.358,86.6,89.6,80.1,197.2,75.9,70.6,85.6,84.9,86.2,88.6,89.5,88.5,80.4,79.2,76.2,195.1,188.6,223.3,73,75.1,75.4,71,69.8,69.7,1683,1667.9,1694,1741.8,1758.2,1738.9,1580.6,1557.1,1496.9,3833.4,3706.4,4388.9,1435.1,1475,1482.6,1394.4,1371.8,1369.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8NEF9","serum response factor-binding protein 1 [OS=Homo sapiens]",14,6,12,6,429,48.6,9.58,30.19,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","SRFBP1","ENSG00000151304","","","",0.443,0.454,0.413,0.398,0.385,85.9,88.1,80.2,194,77.2,74.7,80.4,78.3,85.3,81.8,87.6,82.5,75.1,72.1,77.8,178.2,181.7,288.6,73.7,71.4,72.3,68.4,74.8,69.9,1029,1002.3,1091.9,1046.8,1121,1055.7,960.7,921.8,994.9,2279.8,2324.3,3692.9,943.5,913,924.8,875.4,957.4,894.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q3T906","N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [OS=Homo sapiens]",1,1,1,1,1256,143.5,7.17,4.37,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport","other membranes;ER/Golgi","other molecular function","GNPTAB","ENSG00000111670","Lysosome","","",0.445,0.49,0.505,0.489,0.489,78.1,86,88.7,175.6,85.9,85.8,78.1,78.5,78.1,82.6,88.1,86.1,88.8,94.2,88.2,168.4,178,175.8,85.9,87.8,81.8,83.5,85.9,90.2,145.2,146,145.3,153.5,163.8,160,165,175.1,164,313.2,331,326.8,159.8,163.3,152.1,155.2,159.6,167.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q03989","AT-rich interactive domain-containing protein 5A [OS=Homo sapiens]",6,3,4,3,594,64,9.25,6.68,"stress response;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ARID5A","ENSG00000196843","","","",0.446,0.459,0.415,0.412,0.367,86.3,88.8,80.3,193.7,79.8,71,89.6,83.2,86.8,89.3,96.8,85,81.9,77.2,80.7,207.5,194.6,175,82.9,80.2,76.5,73.8,67.5,71.4,472.8,439.2,457.8,471.1,510.8,448.3,432.4,407.2,425.9,1094.7,1027,923.3,437.7,423.4,403.8,389.3,356.2,376.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q01581","hydroxymethylglutaryl-CoA synthase, cytoplasmic [OS=Homo sapiens]",20,9,22,9,520,57.3,5.41,67.63,"other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","other molecular function","HMGCS1","ENSG00000112972","Valine, leucine and isoleucine degradation; Butanoate metabolism; Terpenoid backbone biosynthesis; Metabolic pathways; PPAR signaling pathway","PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Endochondral ossification; Endochondral ossification with skeletal dysplasias",0.452,0.463,0.453,0.467,0.436,82.9,84.9,83.1,183.4,85.7,80,86.7,87.6,85.9,89.2,88.3,88.8,85.8,86.9,87.4,191.9,194,105.3,88.3,92.9,89.6,83.6,85.4,82.2,2574.2,2601.3,2548.6,2648.3,2620.2,2636.5,2548.3,2580.4,2593.5,5696.1,5759.4,3125.9,2620.3,2758.7,2660.3,2482.7,2536.5,2441.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96A19","Coiled-coil domain-containing protein 102A [OS=Homo sapiens]",8,3,3,3,550,62.6,5.58,11.28,"","cytoskeleton","","CCDC102A","ENSG00000135736","","","",0.452,0.385,0.379,0.372,0.429,89.9,76.6,75.4,198.8,73.9,85.4,70.7,88.6,88.8,68.9,75.6,102.1,79.9,69.6,74.4,196.1,188.1,221.2,92.2,62.9,72.9,84.2,93.2,70.5,141.1,176.9,177.3,137.5,150.8,203.8,159.6,139,148.5,391.4,375.6,441.6,184,125.6,145.5,168.1,186.1,140.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O75683","Surfeit locus protein 6 [OS=Homo sapiens]",17,3,6,3,361,41.4,10.64,16.61,"other biological processes","nucleus;other cell component","nucleic acid binding activity","SURF6","ENSG00000148296; ENSG00000281309","","","",0.458,0.516,0.459,0.447,0.375,84.4,95.1,84.6,184.3,82.4,69.2,76.5,93.4,82.9,93.5,102.7,91.7,88.1,83.1,60,174.5,181.1,240.4,81,67.7,84.7,61.3,69.6,68,47.1,57.5,51,57.5,63.2,56.4,54.3,51.1,36.9,107.4,111.5,148,49.8,41.7,52.1,37.7,42.8,41.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NZM5","ribosome biogenesis protein NOP53 [OS=Homo sapiens]",6,2,4,2,478,54.4,10.32,11.84,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NOP53","ENSG00000105373","","","",0.458,0.432,0.404,0.427,0.439,87,82.1,76.7,189.9,81.1,83.3,73.2,91,96.8,84.8,85.8,87.9,83.1,80.1,75.4,198.4,207.3,149.9,85.4,84.7,78.7,91.8,87.1,58.6,59.2,73.6,78.3,68.6,69.4,71.1,67.2,64.8,61,160.5,167.7,121.2,69.1,68.5,63.6,74.3,70.4,47.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NRZ9","Lymphoid-specific helicase [OS=Homo sapiens]",14,10,17,10,838,97,7.93,47.62,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","other molecular function","HELLS","ENSG00000119969","","","Apoptosis; Apoptosis-related network due to altered Notch3 in ovarian cancer",0.458,0.448,0.485,0.538,0.539,79.3,77.5,83.9,173,93.1,93.2,83.6,79.9,79.1,78.1,77.9,79,86,84.6,82.4,174.4,179.9,153.6,93.9,94.5,92.1,90.5,94,96.4,1359.3,1299.5,1286.2,1269.7,1266.2,1284.5,1398,1375.6,1339.2,2834.9,2924.5,2496.3,1526.5,1535.7,1497.2,1470.4,1528.3,1567.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q52LR7","enhancer of polycomb homolog 2 [OS=Homo sapiens]",1,1,1,1,807,91,8.73,0,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus","","EPC2","ENSG00000135999","","","",0.459,0.409,0.474,0.375,0.522,85,75.7,87.8,185.3,69.5,96.7,53.7,89.9,60,53.4,86.4,46,55.1,61.9,68.3,130.7,128.9,616.1,49.1,42.3,62.2,68.2,56.2,71.5,11.2,18.7,12.5,11.1,18,9.6,11.5,12.9,14.2,27.2,26.8,128.3,10.2,8.8,13,14.2,11.7,14.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q14493-1","Histone RNA hairpin-binding protein [OS=Homo sapiens]",8,2,2,2,270,31.3,7.47,4.48,"RNA metabolism OR transcription;other metabolic processes;transport","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SLBP","ENSG00000163950; ENSGGOG00000003167","","RNA Polymerase II Transcription Termination; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; Transport of the SLBP Dependant Mature mRNA","",0.46,0.5,0.627,0.795,0.677,68,74,92.7,147.8,117.5,100.1,69.1,61.6,80.1,105.6,75.2,66.8,94.2,97.2,77.8,171.4,150.3,109.4,119.5,124.1,86.1,123.4,101.8,86.3,60.6,54,70.2,92.6,66,58.5,82.6,85.3,68.2,150.3,131.9,96,104.8,108.8,75.5,108.2,89.3,75.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y6Y0","influenza virus NS1A-binding protein [OS=Homo sapiens]",1,1,1,1,642,71.7,5.53,0,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","","IVNS1ABP","ENSG00000116679","","","",0.46,0.488,0.524,0.473,0.537,79.3,84.1,90.3,172.3,81.5,92.5,84.3,84.6,75.6,90.1,75.8,89.4,80.7,100,96,209.1,183.1,80.9,75.2,94.1,86.7,89.7,106.7,98.3,57.9,58.1,51.9,61.8,52,61.4,55.4,68.6,65.9,143.5,125.7,55.5,51.6,64.6,59.5,61.5,73.2,67.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P32246","C-C chemokine receptor type 1 [OS=Homo sapiens]",3,1,1,1,355,41.1,8.16,1.86,"cell adhesion;cell-cell signaling;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","CCR1","ENSG00000163823","Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor; Chemokine signaling pathway; Human cytomegalovirus infection; Kaposi sarcoma-associated herpesvirus infection","G alpha (i) signalling events; Chemokine receptors bind chemokines; Interleukin-10 signaling","Peptide GPCRs; Chemokine signaling pathway; Selective expression of chemokine receptors during T-cell polarization; GPCRs, class A rhodopsin-like; CCL18 signaling pathway",0.462,0.476,0.448,0.47,0.449,83.9,86.4,81.4,181.5,85.3,81.5,83.7,82.6,87.8,92.1,85.9,86.2,72.5,87,81.2,181.1,191.1,168.6,85.1,87.6,83.6,80.1,81.3,82.7,119.3,117.7,125.1,131.3,122.5,122.9,103.4,124,115.7,258.2,272.4,240.4,121.3,124.9,119.2,114.2,115.9,117.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P08887-1","Interleukin-6 receptor subunit alpha [OS=Homo sapiens]",2,1,1,1,468,51.5,8.22,2.3,"other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","other molecular function","IL6R","ENSG00000160712","EGFR tyrosine kinase inhibitor resistance; Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor; HIF-1 signaling pathway; PI3K-Akt signaling pathway; JAK-STAT signaling pathway; Hematopoietic cell lineage; Th17 cell differentiation; Non-alcoholic fatty liver disease; Human cytomegalovirus infection; Coronavirus disease; Pathways in cancer","Transcriptional regulation of granulopoiesis; Potential therapeutics for SARS; Interleukin-4 and Interleukin-13 signaling; Interleukin-6 signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation","Pluripotent stem cell differentiation pathway; IL-6 signaling pathway; Hepatitis C and hepatocellular carcinoma; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Nonalcoholic fatty liver disease; Regulatory circuits of the STAT3 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Neuroinflammation and glutamatergic signaling; Senescence and autophagy in cancer; Sudden infant death syndrome (SIDS) susceptibility pathways",0.464,0.522,0.507,0.502,0.483,80,90,87.4,172.5,86.6,83.4,48.1,67.8,70.2,76.4,85.8,62.9,74.6,74.1,67.9,122,146.3,472,80.3,61.2,73.5,70.4,70.7,75.9,60.9,86,89.1,96.8,108.8,79.8,94.6,94,86.1,154.7,185.5,598.3,101.8,77.5,93.2,89.2,89.7,96.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9P013","spliceosome-associated protein CWC15 homolog [OS=Homo sapiens]",12,3,3,3,229,26.6,5.71,6.67,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus","nucleic acid binding activity","CWC15","ENSG00000150316","Spliceosome","mRNA Splicing - Major Pathway","",0.464,0.975,1.347,1.166,0.561,50.5,106.2,146.6,108.8,126.9,61,48.1,38.1,147.4,101.1,106.3,55.7,141.8,139.6,117,146.3,71.5,103.6,120.8,74.8,142,142,58.1,45.9,105.8,83.9,324.5,222.5,233.9,122.6,312.1,307.2,257.5,322,157.3,228.1,265.9,164.7,312.6,312.6,127.9,100.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8IVM0","Coiled-coil domain-containing protein 50 [OS=Homo sapiens]",31,8,12,8,306,35.8,6.65,35.85,"other biological processes","cytosol","other molecular function","CCDC50","ENSG00000152492","","","",0.464,0.64,0.667,0.635,0.519,71,97.8,101.9,152.9,97.1,79.3,69.4,69.7,107.8,106.8,96,82,100,103.8,95.5,150,124.7,159.1,95.3,89.8,98.5,101.5,77.8,72.2,819.6,822.6,1273.3,1261.7,1133.2,967.8,1180.9,1226,1127.6,1771.5,1472.9,1879,1125.4,1060.6,1162.9,1198.4,919.1,852.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P30279","G1/S-specific cyclin-D2 [OS=Homo sapiens]",3,1,1,1,289,33,5.19,2.59,"cell cycle OR cell proliferation;other biological processes","other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","CCND2","ENSG00000118971","FoxO signaling pathway; Cell cycle; p53 signaling pathway; PI3K-Akt signaling pathway; Cellular senescence; Wnt signaling pathway; Hedgehog signaling pathway; Hippo signaling pathway; Focal adhesion; JAK-STAT signaling pathway; Prolactin signaling pathway; Measles; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Epstein-Barr virus infection; Pathways in cancer; Transcriptional misregulation in cancer; Viral carcinogenesis; MicroRNAs in cancer","Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Regulation of RUNX1 Expression and Activity","miRNA regulation of DNA damage response; Cell cycle; SRF and miRs in smooth muscle differentiation and proliferation; Glioblastoma signaling pathways; Focal adhesion; Ovarian infertility; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Hedgehog signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; G1 to S cell cycle control; IL-2 signaling pathway; Malignant pleural mesothelioma; DNA damage response; DNA damage response (only ATM dependent)",0.465,0.441,0.395,0.437,0.44,87.8,83.2,74.6,188.8,82.5,83.2,79.1,83.9,80.8,90.9,76.6,72,114.7,67.9,68.6,150,173.8,276.9,75.9,96.1,68,77.7,76.5,70.8,135.1,143.3,138,155.4,130.8,123.1,196,116,117.3,256.3,297,473.2,129.7,164.2,116.2,132.8,130.8,121.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q15004-1","PCNA-associated factor [OS=Homo sapiens]",30,2,2,2,111,12,9.83,6.85,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","PCLAF","ENSG00000166803; ENSPPAG00000022409; ENSPTRG00000007159","","Termination of translesion DNA synthesis","",0.465,0.476,0.502,0.565,0.529,78.9,80.7,85.2,169.6,95.8,89.7,67.7,79.3,91,78.4,81,81.7,85.6,91.4,76.7,170.3,167.6,178.5,95.9,99.1,96.2,90.1,95.2,74.3,90.2,105.6,121.2,104.5,108,108.9,114,121.7,102.3,226.9,223.4,237.9,127.8,132.1,128.2,120,126.9,99,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NW75-1","G patch domain-containing protein 2 [OS=Homo sapiens]",5,2,2,2,528,58.9,9.09,7.27,"other biological processes","nucleus","nucleic acid binding activity","GPATCH2","ENSG00000092978","","","",0.469,0.483,0.455,0.518,0.446,83.4,86,81.1,177.9,92.2,79.4,81.3,90.2,79,94,83.8,68.7,107.1,76.9,79,149.3,173.4,230,89.8,91.7,74.9,84.4,69.2,77.4,67.6,75.1,65.7,78.2,69.8,57.2,89.2,64,65.7,124.3,144.3,191.5,74.8,76.3,62.4,70.3,57.6,64.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BRP8","Partner of Y14 and mago [OS=Homo sapiens]",9,1,2,1,204,22.6,9.45,7.99,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","translation activity","PYM1","ENSG00000170473","Nucleocytoplasmic transport; mRNA surveillance pathway","","",0.469,0.662,0.608,0.597,0.471,73.9,104.4,95.9,157.6,94.1,74.2,64,68.5,78.7,96.7,170.3,65.3,171.7,88.8,88,146,67.2,179.8,90.9,60,87.2,67.8,68.7,140.1,64,68.5,78.7,96.7,170.2,65.3,171.6,88.8,88,146,67.2,179.7,90.9,59.9,87.1,67.8,68.7,140.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P16619","C-C motif chemokine 3-like 1 [OS=Homo sapiens]",24,2,10,2,93,10.2,4.89,30.53,"stress response;signal transduction;other biological processes","non-structural extracellular","signal transduction activity or receptor binding","CCL3L1; CCL3L3","ENSG00000276085; ENSG00000277336; ENSG00000277768; ENSG00000277796","Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor; Chemokine signaling pathway; Toll-like receptor signaling pathway; Chagas disease; Human cytomegalovirus infection; Rheumatoid arthritis; Lipid and atherosclerosis","Chemokine receptors bind chemokines; Interleukin-10 signaling","Overview of proinflammatory and profibrotic mediators",0.47,0.581,0.535,0.531,0.452,79,97.7,89.9,168.1,89.2,76,79.2,86.6,79.6,100.6,98.4,96.2,90.6,92.3,81,142.2,169.3,184.2,89.9,92.4,79.1,76.6,87.7,73.9,942.1,1029.7,946.9,1197.1,1171.1,1144.7,1078,1097.9,963.5,1691.6,2014.3,2191.2,1069.5,1099.5,940.5,911.2,1043.4,879.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96NB3","zinc finger protein 830 [OS=Homo sapiens]",6,3,7,2,372,42,5.31,16.91,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF830","ENSG00000198783","","Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER","",0.471,0.53,0.566,0.532,0.601,76.3,85.9,91.9,162.2,86.2,97.5,71.6,74.9,99.2,90.3,83.3,84.3,106.5,90.1,78.9,159,146.2,192.4,87.2,84.6,82.4,103.6,95.7,69.7,204.3,213.5,282.9,257.6,237.6,240.3,303.9,256.9,225.1,453.6,417,548.7,248.7,241.2,235.1,295.6,272.8,198.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H4F8","SPARC-related modular calcium-binding protein 1 [OS=Homo sapiens]",3,1,1,1,434,48.1,8.22,0,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;extracellular matrix","other molecular function","SMOC1","ENSG00000198732","","","",0.475,0.51,0.505,0.487,0.541,81,87,86.2,170.6,83.1,92.2,81.2,81.3,95.7,87.4,73.8,88.8,86.6,74,89.8,171.4,187.8,134,82.7,95.1,83.5,92.6,91.4,102.8,122.1,122.2,143.8,131.4,111,133.5,130.1,111.2,135,257.6,282.3,201.4,124.3,142.9,125.5,139.2,137.4,154.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q53RE8","ankyrin repeat domain-containing protein 39 [OS=Homo sapiens]",11,1,1,1,183,19.6,6.89,5,"protein metabolism;other metabolic processes","nucleus","","ANKRD39","ENSG00000213337","","","",0.478,0.507,0.468,0.698,0.576,76.9,81.6,75.3,161,112.5,92.7,73.1,92,75.4,63,83.5,80,82.8,70.5,73.8,144.1,157.9,254.1,112.4,110.3,71.4,90.9,73.5,91.1,35.7,44.9,36.8,30.7,40.8,39.1,40.4,34.4,36,70.3,77,124,54.9,53.8,34.9,44.4,35.9,44.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NUQ6-2","Isoform 2 of SPATS2-like protein [OS=Homo sapiens]",31,15,22,1,489,54.1,9.63,51.09,"","","","SPATS2L","","","","",0.481,0.452,0.442,0.465,0.443,87.9,82.7,80.7,182.8,84.9,80.9,84.2,86.6,79.9,79.2,78,86,73.2,77.3,87.3,175.1,163.7,241.1,78.7,85.5,81.3,75.4,89.9,77.5,170.8,175.7,162.1,160.7,158.2,174.6,148.4,156.8,177,355.2,332.2,489.2,159.7,173.6,165,153.1,182.5,157.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y2R4","Probable ATP-dependent RNA helicase DDX52 [OS=Homo sapiens]",18,7,19,7,599,67.5,9.67,57.45,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","DDX52","ENSG00000277594; ENSG00000278053","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","Orexin receptor pathway",0.483,0.521,0.449,0.479,0.431,86.2,93,80.2,178.3,85.4,76.9,84.6,93.7,88.1,95,90.6,97.5,79.4,82.7,82,185.9,182.3,135.4,88.6,87.3,83.5,78.7,88.2,76.4,803.9,890,837.2,902.7,861,926.6,753.8,785.2,778.4,1766.2,1732,1286.2,841.4,829.3,793.1,747.3,837.9,725.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P04818","thymidylate synthase [OS=Homo sapiens]",15,5,6,5,313,35.7,7.01,3.92,"DNA metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","TYMS","ENSG00000176890","Pyrimidine metabolism; One carbon pool by folate; Metabolic pathways; Antifolate resistance","Interconversion of nucleotide di- and triphosphates; G1/S-Specific Transcription","Fluoropyrimidine activity; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration and one-carbon metabolism; One-carbon metabolism and related pathways; Ethanol effects on histone modifications; Pyrimidine metabolism",0.484,0.542,0.538,0.529,0.543,79.9,89.5,88.7,165,87.2,89.6,79.6,84.8,77.8,93.3,85.6,89.1,86.1,88.4,89.5,162.4,176,164.4,86.9,81.4,91,89.3,82.7,92,285.9,304.9,279.5,335.3,307.6,320.3,309.4,317.7,321.5,583.7,632.5,590.8,312.2,292.5,326.9,320.9,297.3,330.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O75794","Cell division cycle protein 123 homolog [OS=Homo sapiens]",24,6,16,6,336,39.1,4.81,41.87,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","other cell component","","CDC123","ENSG00000151465","","","",0.485,0.517,0.479,0.5,0.466,84.4,90,83.4,174.1,87,81.1,83.5,87.5,82.5,91.3,88.8,89.1,86.5,82.6,82.5,172.3,170.9,182,84.3,86.1,86.9,80.3,79.5,83.4,792.3,829.7,783,866.4,842.2,845.5,821,783.3,782.5,1634.7,1621,1726.7,799.9,816.9,824.2,762,753.8,791,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O60861-1","Isoform 1 of Growth arrest-specific protein 7 [OS=Homo sapiens]",7,2,3,2,412,47.2,7.58,8.59,"","","","GAS7","","","","",0.485,0.497,0.494,0.462,0.569,83,85,84.6,171.1,79,97.3,88.1,92.2,88.4,90.5,79.5,96.6,84,94.2,90,183.3,182.2,53.1,98.1,80.7,84.2,103.6,107.9,103.5,278.8,291.7,279.8,286.4,251.7,305.7,265.7,298,284.9,580.2,576.6,168,310.3,255.4,266.4,327.8,341.5,327.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O95229","ZW10 interactor [OS=Homo sapiens]",8,2,2,2,277,31.3,5.15,5.15,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","ZWINT","ENSG00000122952","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",0.487,0.485,0.424,0.414,0.518,87.8,87.5,76.4,180.3,74.6,93.3,88.7,105.8,74.9,85.4,88.5,101.5,75,77.2,85.9,146.4,185.1,182.3,80.1,75.4,72.4,77.2,103.7,94.4,197.4,235.4,166.6,190.1,196.9,225.9,166.8,171.9,191,325.7,411.9,405.6,178.3,167.8,161.2,171.9,230.8,209.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O15213","WD repeat-containing protein 46 [OS=Homo sapiens]",21,11,15,11,610,68,9.67,46.35,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","WDR46","ENSG00000204221; ENSG00000206284; ENSG00000226916; ENSG00000227057; ENSG00000236222","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",0.487,0.543,0.497,0.478,0.477,84,93.6,85.6,172.3,82.3,82.2,82.2,85.9,82,91.5,89.5,94.8,83,85.3,83.7,158.8,168.6,211.2,80.5,77.2,83.5,81.7,80.5,80.2,829.8,868,828.1,924.7,903.9,957.8,838.1,861.8,845.8,1603.9,1703,2132.8,813.3,779.6,843.2,824.8,812.7,809.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y4L5","E3 ubiquitin-protein ligase RNF115 [OS=Homo sapiens]",3,1,1,1,304,33.7,5.69,1.74,"protein metabolism;other metabolic processes;other biological processes","cytosol","other molecular function","RNF115","ENSG00000265491","","Antigen processing: Ubiquitination & Proteasome degradation","",0.491,0.616,0.476,0.459,0.467,84,105.3,81.4,171,78.5,79.8,80,75.7,89.3,82.4,100.3,104.6,77.5,97.1,74.8,144.6,162.9,262.7,71.4,74.7,87.6,61,77.4,76,54.1,51.2,60.4,55.7,67.8,70.7,52.4,65.7,50.6,97.7,110.1,177.6,48.2,50.5,59.2,41.2,52.3,51.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q16850-1","lanosterol 14-alpha demethylase [OS=Homo sapiens]",18,8,14,8,503,56.8,8.53,43.27,"","","","","","","","",0.494,0.46,0.45,0.478,0.442,89.2,83,81.2,180.5,86.3,79.8,83.5,90.1,91.2,89.2,83.9,83.2,89.1,82.1,76.9,182.4,196.2,149.6,87.2,89.7,83.4,78.6,80.6,82.9,1026.2,1107.4,1120.8,1096.5,1031.1,1022.5,1095.2,1008.6,944.4,2240.7,2410.9,1838.3,1071.3,1101.5,1024.8,966.2,990.7,1018.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y6V7","Probable ATP-dependent RNA helicase ddx49 [OS=Homo sapiens]",10,3,4,3,483,54.2,9.06,15.77,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","DDX49","ENSG00000105671","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",0.495,0.555,0.445,0.505,0.44,86.3,96.7,77.7,174.4,88.2,76.7,79.6,90,90.9,100.9,104,95.1,86.7,81,80.2,186.7,182,115.2,92,93.4,83.9,80.1,81.3,77,294.1,332.9,336,373.1,384.7,351.7,320.5,299.7,296.6,690.1,672.8,426,340,345.5,310.2,296,300.5,284.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O75626-1","PR domain zinc finger protein 1 [OS=Homo sapiens]",5,4,9,3,825,91.7,8.48,18.45,"cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","PRDM1","ENSG00000057657","","STAT3 nuclear events downstream of ALK signaling; Regulation of TP53 Expression","Nucleotide-binding oligomerization domain (NOD) pathway; Vitamin D receptor pathway; IL-6 signaling pathway; Overview of leukocyte-intrinsic Hippo pathway functions",0.495,0.476,0.43,0.456,0.449,89.9,86.4,78,181.5,82.7,81.5,90.1,88,86.8,83.8,96.9,84.6,76.4,80.5,76.1,172.9,196,177.7,80.6,84.6,81,78.9,79.8,85.1,292.6,285.8,281.9,272,314.7,274.7,248,261.4,246.9,561.4,636.4,576.9,261.6,274.6,262.8,256,259,276.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P14316-1","Interferon regulatory factor 2 [OS=Homo sapiens]",13,3,4,3,349,39.3,7.52,13.93,"cell cycle OR cell proliferation;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","IRF2","ENSG00000168310; ENSGGOG00000016559","","Factors involved in megakaryocyte development and platelet production; Interferon gamma signaling; Interferon alpha/beta signaling; Pyroptosis","Apoptosis; Type II interferon signaling (IFNG)",0.499,0.528,0.554,0.48,0.509,83.8,88.7,93.1,168.1,80.6,85.6,83.8,87.8,94.5,104.5,92.9,91.3,97.5,99.2,88.2,183,175.9,80.5,96.7,84.4,84.1,91.4,89.6,74.8,470.2,492.2,529.9,586,520.9,511.9,546.8,556.1,494.7,1026.5,986.7,451.4,542.6,473.3,471.6,512.7,502.4,419.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8TDB6-1","E3 ubiquitin-protein ligase DTX3L [OS=Homo sapiens]",1,1,1,1,740,83.5,8.06,2.45,"protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","DTX3L","ENSG00000163840","Notch signaling pathway","Antigen processing: Ubiquitination & Proteasome degradation","Notch signaling",0.5,0.503,0.47,0.457,0.459,88.5,89,83.3,177.1,81,81.3,88.2,87.5,76.3,85.4,88.1,103.3,80.7,82.4,83.8,175.2,160.3,192.5,80.1,86.1,80,80.4,67.8,102,64.6,64.1,55.9,62.5,64.5,75.6,59.1,60.3,61.3,128.3,117.4,140.9,58.6,63,58.5,58.9,49.7,74.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96JE7-1","Protein transport protein Sec16B [OS=Homo sapiens]",1,1,1,1,1060,116.5,6.09,0,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","","SEC16B","ENSG00000120341","","COPII-mediated vesicle transport","",0.501,0.545,0.579,0.533,0.541,81.2,88.4,93.9,162.2,86.4,87.8,78.2,88.8,63.9,75.9,85.2,89.4,90.4,102.6,83.4,156.2,122,246.5,121.2,83.2,62.7,84.5,87.2,78.6,21.2,24.1,17.4,20.6,23.1,24.3,24.5,27.8,22.6,42.4,33.1,66.9,32.9,22.6,17,22.9,23.7,21.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6DKI1","60S ribosomal protein L7-like 1 [OS=Homo sapiens]",13,3,10,3,246,28.6,10.51,32.49,"","","","","","","","",0.504,0.547,0.455,0.467,0.456,88.2,95.8,79.6,175,81.7,79.8,90.6,93.5,90,95,100.9,98.4,81.4,86,81.8,179.9,180.5,125.5,81.5,86.6,84,82,83.9,78.5,950.5,981,943.6,995.9,1058.4,1032.4,853.3,901.6,857.7,1887,1893.3,1315.8,854.6,907.7,881.1,859.8,879.4,823.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6I9Y2","THO complex subunit 7 homolog [OS=Homo sapiens]",10,2,2,2,204,23.7,5.67,7.35,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","THOC7","ENSG00000163634","Nucleocytoplasmic transport","RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing","",0.505,0.482,0.358,0.439,0.556,90.7,86.6,64.3,179.7,78.8,99.8,115.8,92.5,68.6,66.4,89.4,88.4,91.4,65.6,63.2,183.4,130.5,229.5,80.5,85,65.6,74.6,101.9,107.9,254.8,203.6,150.9,146.1,196.7,194.4,201.1,144.4,139,403.5,287.1,504.9,177,187.1,144.4,164.2,224.2,237.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NY93","Probable ATP-dependent RNA helicase DDX56 [OS=Homo sapiens]",13,5,6,5,547,61.6,9.26,17,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","DDX56","ENSG00000136271","","","",0.505,0.546,0.539,0.486,0.494,84.9,91.7,90.6,168.1,81.6,83.1,87.3,85.2,88.2,88.2,94.3,95.2,93.1,96,90.4,177.8,172.9,128.7,81.2,84,84,80.1,85.4,87.8,435.1,424.4,439.2,439.3,469.9,474.4,464,478.4,450.2,885.9,861.4,641.1,404.4,418.6,418.3,399,425.6,437.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q7Z5Y7","BTB/POZ domain-containing protein KCTD20 [OS=Homo sapiens]",4,1,1,1,419,47.5,5.33,3.81,"other biological processes","other cell component","","KCTD20","ENSG00000112078","","","",0.507,0.565,0.48,0.564,0.578,82.4,91.8,78,162.4,91.6,93.8,80.5,92.7,82.4,96.8,80.2,91.8,80.4,69.9,78,162.4,206.8,127.6,82.7,91.6,92.9,85.3,104,93.8,22.1,25.4,22.6,26.6,22,25.2,22.1,19.2,21.4,44.6,56.8,35,22.7,25.1,25.5,23.4,28.6,25.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P42575-1","caspase-2 [OS=Homo sapiens]",14,4,4,4,452,50.7,6.81,13.78,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","other molecular function","CASP2","ENSG00000106144; ENSPPAG00000028627; ENSPTRG00000019805; ENSPTRG00000047033","Apoptosis","TP53 Regulates Transcription of Caspase Activators and Caspases; NOD1/2 Signaling Pathway; NADE modulates death signalling","Apoptosis modulation and signaling; Parkinson's disease pathway; Apoptosis; Apoptosis modulation by HSP70; Acute viral myocarditis; Apoptosis modulation by HSP70",0.508,0.517,0.523,0.507,0.483,86.1,87.6,88.8,169.6,86,82,90.3,85.2,86.1,87.7,84.9,87.6,91.8,88.8,82.8,169.6,164.3,173.3,81.5,92.1,86,77.2,82,89,161.3,152.1,153.7,156.6,151.7,156.5,164,158.5,147.9,302.9,293.4,309.6,145.5,164.4,153.5,137.9,146.4,158.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P28324","ETS domain-containing protein Elk-4 [OS=Homo sapiens]",4,1,1,1,431,46.9,7.91,4.14,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ELK4","ENSG00000158711","MAPK signaling pathway; Human T-cell leukemia virus 1 infection; Transcriptional misregulation in cancer","","Mesodermal commitment pathway; MAPK signaling pathway; EGF/EGFR signaling pathway; ID signaling pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling",0.508,0.612,0.444,0.56,0.503,84,101.3,73.4,165.5,92.7,83.1,78.1,95.2,82.9,99.7,100.5,99.9,98.9,66.7,72.4,143.5,163.2,178,91,91.4,96,87.1,73.6,82,60.2,73.4,63.9,76.8,77.5,77,76.2,51.4,55.8,110.6,125.8,137.2,70.2,70.4,74,67.2,56.7,63.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9ULV3","Cip1-interacting zinc finger protein [OS=Homo sapiens]",13,8,10,8,898,100,6.11,27.44,"other biological processes","plasma membrane;other membranes;nucleus","nucleic acid binding activity;other molecular function","CIZ1","ENSG00000148337","","","",0.509,0.534,0.53,0.532,0.534,83.9,88,87.4,164.9,87.7,88,78.6,84.8,86.8,89,87.3,90.9,84.4,90.6,88.4,153.6,166.7,167.9,88.6,83.8,90.1,88.9,92.3,87.4,411.3,443.8,454.1,465.7,456.8,475.8,441.9,474.3,462.5,803.6,872.4,878.5,463.9,438.8,471.5,465.4,483.2,457.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96PU8","protein quaking [OS=Homo sapiens]",17,5,7,5,341,37.6,8.56,21.59,"RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","QKI","ENSG00000112531","","Signaling by BRAF and RAF1 fusions","VEGFA-VEGFR2 signaling pathway; Exercise-induced circadian regulation",0.511,0.542,0.552,0.497,0.519,84.7,89.7,91.5,165.7,82.4,85.9,83.8,84.5,89.7,89.5,92.8,89.2,92.6,91.2,88.5,152.8,165.2,176.8,82.3,82.2,81.7,87.4,85.7,84.3,567.1,571.7,607.1,605.5,627.9,603.7,626.8,617.5,598.9,1034,1118.2,1196.7,557.1,556,553.1,591.4,579.9,570.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q68CJ6","Nuclear GTPase SLIP-GC [OS=Homo sapiens]",3,3,3,3,796,91.1,8.63,6.55,"other biological processes","nucleus","other molecular function","NUGGC","ENSG00000189233","","","",0.511,0.557,0.513,0.561,0.529,83.6,91,83.8,163.4,91.7,86.5,62.6,59.9,67.6,68.2,74.6,57.1,69.8,61.5,62.8,122.5,105.2,593.4,65.7,69.3,68.7,56.8,69.5,64.8,195.7,187.3,211.4,213.2,233,178.4,218.2,192.1,196.3,382.8,328.8,1854.8,205.4,216.7,214.7,177.5,217.2,202.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q71RC2","La-related protein 4 [OS=Homo sapiens]",8,5,8,5,724,80.5,6.61,23.37,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity","LARP4","ENSG00000161813","","","",0.511,0.508,0.506,0.523,0.513,86.2,85.5,85.3,168.5,88.1,86.4,82.1,86.5,89.8,85.8,88.6,85.8,84.1,85.8,85.6,169.1,176.8,157.4,88.4,84.8,89.7,83.7,86.7,89.1,671.4,707.2,734.7,701.9,724.9,701.8,687.9,701.9,700.2,1382.8,1445.9,1287.4,722.8,693.4,733.9,684.5,709,728.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9P275","Ubiquitin carboxyl-terminal hydrolase 36 [OS=Homo sapiens]",3,4,6,4,1121,122.6,9.67,13.86,"","","","","","","","",0.513,0.555,0.503,0.463,0.434,88.7,96,87,173.1,80.1,75.1,84.6,87.1,89.4,92,98.9,94.2,87.7,85.4,82.9,169.9,195.7,169.9,78.7,78.2,81.1,73.1,77.3,73.8,263.4,271.4,278.5,286.5,307.9,293.5,273.2,266.1,258.3,529.1,609.7,529.3,245,243.5,252.6,227.8,240.7,229.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q99081-1","Transcription factor 12 [OS=Homo sapiens]",7,4,4,4,682,72.9,7.02,8.37,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TCF12","ENSG00000140262","","RUNX1 regulates transcription of genes involved in differentiation of HSCs; Myogenesis; NGF-stimulated transcription","",0.513,0.531,0.516,0.473,0.52,86.7,89.7,87.1,168.8,79.9,87.7,79.3,86.6,86.8,87.1,102.5,89.6,79.5,88.8,87,168.7,183.7,158.6,79.9,76,88.2,79.7,87.7,90.6,127.2,138.9,139.3,139.8,164.5,143.9,127.5,142.5,139.7,270.7,294.8,254.5,128.1,121.9,141.5,128,140.7,145.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P48431","Transcription factor SOX-2 [OS=Homo sapiens]",3,1,1,1,317,34.3,9.74,1.83,"cell organization and biogenesis;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SOX2","ENSG00000181449","Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells","Interleukin-4 and Interleukin-13 signaling; POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation; Transcriptional Regulation by MECP2; Deactivation of the beta-catenin transactivating complex; POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation","Cell differentiation - expanded index; Cardiac progenitor differentiation; Endoderm differentiation; Dopaminergic neurogenesis; Mesodermal commitment pathway; Ectoderm differentiation; let-7 inhibition of ES cell reprogramming; Pre-implantation embryo; Wnt signaling pathway and pluripotency; Sudden infant death syndrome (SIDS) susceptibility pathways",0.515,0.552,0.505,0.545,0.548,84.3,90.4,82.7,163.7,89.2,89.6,75.9,75.7,81.1,90,81.4,79.5,78.9,74.4,69,146.2,147.4,312.3,80.3,87.4,77.2,84.3,78.3,80.7,160.3,159.7,171.2,190.1,171.9,167.9,166.7,157.2,145.6,308.6,311.1,659.5,169.6,184.6,163,178,165.2,170.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96T21","selenocysteine insertion sequence-binding protein 2 [OS=Homo sapiens]",1,1,1,1,854,95.4,8.12,2.01,"protein metabolism;other metabolic processes;developmental processes;other biological processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","SECISBP2","ENSG00000187742","","Selenocysteine synthesis","",0.519,0.58,0.538,0.521,0.601,82.9,92.6,85.9,159.6,83.2,96,76,66,75.2,84,89,79.7,74.4,78,83.2,142.5,144.9,344.2,60.3,75.5,78.5,87.1,73.7,88,41.8,36.3,41.4,46.3,49,43.9,41,42.9,45.8,78.5,79.8,189.5,33.2,41.6,43.2,48,40.6,48.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y575","Ankyrin repeat and SOCS box protein 3 [OS=Homo sapiens]",2,1,1,1,518,57.7,6.27,2.27,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol","","ASB3","ENSG00000115239","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",0.52,0.577,0.475,0.505,0.471,88,97.5,80.3,169.1,85.4,79.7,81.6,76.5,83,90.4,98.9,81.7,67.1,74.5,81.7,156.9,147.5,292.5,77.6,83,79.2,69,73.9,84.9,80.8,75.8,82.2,89.6,98,81,66.5,73.8,81,155.4,146.1,289.7,76.8,82.2,78.5,68.4,73.2,84.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q06413-1","Myocyte-specific enhancer factor 2C [OS=Homo sapiens]",10,4,10,4,473,51.2,8.03,30.45,"cell-cell signaling;cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","MEF2C","ENSAMEG00000013271; ENSCANG00000018420; ENSCATG00000041293; ENSCJAG00000010799; ENSECAG00000024716; ENSFCAG00000011595; ENSG00000081189; ENSGGOG00000002856; ENSLCNG00005002290; ENSMLEG00000034952; ENSMMUG00000019836; ENSMNEG00000035741; ENSNLEG00000013673; ENSPCOG00000015854; ENSPPAG00000039315; ENSPTRG00000024214; ENSRBIG00000040542; ENSSSUG00005022076; ENSTSYG00000003647; ENSUAMG00000022640; ENSVVUG00000022531","MAPK signaling pathway; cGMP-PKG signaling pathway; Apelin signaling pathway; Oxytocin signaling pathway; Parathyroid hormone synthesis, secretion and action; Transcriptional misregulation in cancer; Fluid shear stress and atherosclerosis","Heme signaling; Circadian Clock; Myogenesis; ERK/MAPK targets; Transcriptional activation of mitochondrial biogenesis; MECP2 regulates transcription factors","Energy metabolism; Heart development; SRF and miRs in smooth muscle differentiation and proliferation; Cell differentiation - expanded index; Cell differentiation - index; B cell receptor signaling pathway; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; MECP2 and associated Rett syndrome; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling pathway; Prion disease pathway; Rett syndrome causing genes; EGF/EGFR signaling pathway; Gastrin signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Sudden infant death syndrome (SIDS) susceptibility pathways; Adipogenesis; MAPK signaling pathway; Delta-Notch signaling pathway",0.523,0.558,0.503,0.512,0.498,87.3,93.2,84,166.9,85.4,83.1,90.7,91.7,96.3,100.7,84.4,97.8,85.6,88.2,90.7,175.3,190.4,81.2,89.7,83,90.6,91.1,87.3,85.2,1179.6,1192.4,1252,1309.9,1097.7,1272.2,1113.2,1147.4,1179.4,2279.5,2475.8,1055.6,1166.1,1078.9,1177.7,1185.1,1135,1108.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BY42","protein RTF2 homolog [OS=Homo sapiens]",26,7,15,7,306,33.9,8.59,39.13,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","RTF2","ENSG00000022277","","","",0.523,0.555,0.521,0.505,0.531,86.4,91.6,85.9,165,83.4,87.7,90.5,90.3,88.2,95.7,87.1,101.3,84.6,89.8,91.9,172.5,180.9,90.3,91.3,84.8,87.1,91.7,95.6,86.5,1558.7,1555.5,1520.5,1650,1501.5,1744.9,1458.1,1548,1582.9,2972.8,3116.8,1555.6,1572.9,1461.6,1501.4,1579.5,1647.9,1490.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y3C1","nucleolar protein 16 [OS=Homo sapiens]",14,3,4,3,178,21.2,9.94,6.24,"other biological processes","nucleus;other cell component","","NOP16","ENSG00000048162","","","",0.523,0.693,0.71,0.678,0.515,76.2,100.9,103.4,145.7,98.7,75.1,74.8,73.8,116.3,101,99,76.3,103.7,101.5,95.4,142.9,118.6,150.8,96.9,85.3,109.2,107.8,73,73.7,279.2,275.5,434,377,369.5,284.7,387.1,378.8,356,533.5,442.7,562.8,361.5,318.2,407.5,402.4,272.6,274.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P78316","Nucleolar protein 14 [OS=Homo sapiens]",13,9,15,9,857,97.6,7.58,37.87,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NOP14","ENSG00000087269","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",0.523,0.509,0.484,0.49,0.452,90.8,88.4,84,173.5,85,78.4,93.9,91.7,89.1,89.5,87.4,89.2,81.7,85.9,84.8,175.2,186.4,156.8,85.9,85.8,80.8,79.4,79.1,77.4,1064,1038.3,1008.8,1014.3,989.9,1010.5,925.8,973.4,960,1984.1,2111,1776.5,973.3,972.1,914.9,899,896,876.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q7L513","Fc receptor-like A [OS=Homo sapiens]",21,5,8,5,359,38.9,5.36,18.68,"signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","FCRLA","ENSG00000132185","","","",0.527,0.578,0.572,0.626,0.618,80.6,88.5,87.5,153,95.8,94.6,71.4,75.8,72.8,85.4,79.9,77.5,88.5,79,78.4,129.4,138.1,310.6,86.5,91.6,80.7,83.7,85.3,85.4,631.1,669.9,643.4,755.4,706.1,684.8,782.8,698.5,693.3,1144.1,1220.8,2746.2,764.4,809.9,713.8,740.3,754.5,755.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BX10","GTP-binding protein 2 [OS=Homo sapiens]",2,1,1,1,602,65.7,8.05,1.96,"protein metabolism;other metabolic processes","non-structural extracellular;other cell component","nucleic acid binding activity;other molecular function","GTPBP2","ENSG00000172432","","Platelet degranulation","Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway",0.53,0.64,0.608,0.473,0.611,82.4,99.4,94.4,155.4,73.5,94.9,84.9,79.5,73.3,89,143.7,95.9,83.2,91.1,95,149.9,111.6,213,68.3,71,84.1,80.6,91.6,94.2,62.6,58.6,54,65.6,105.8,70.7,61.3,67.1,70,110.4,82.2,156.9,50.3,52.3,62,59.4,67.5,69.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q15397","Pumilio homolog 3 [OS=Homo sapiens]",24,16,27,16,648,73.5,9.64,64.03,"other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity","PUM3","ENSG00000080608","","","",0.531,0.55,0.505,0.509,0.495,88.8,91.9,84.3,167.2,85.1,82.7,89.3,90.7,93.7,99.5,89.6,93.9,86.5,85.3,86.2,170.8,179.6,117.7,89.7,86.4,87,85.9,83.7,84.5,2942,2989.9,3087.6,3278,2952.4,3093.7,2850.1,2812.4,2839.8,5628.8,5918,3880.1,2956.8,2846.2,2865.6,2831.7,2756.6,2784.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O76021","Ribosomal L1 domain-containing protein 1 [OS=Homo sapiens]",44,21,75,21,490,54.9,10.13,204.17,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","RSL1D1","ENSG00000171490","","","Senescence and autophagy in cancer",0.532,0.547,0.505,0.479,0.462,90.5,93.1,85.9,170.3,81.6,78.6,92.3,89,91.3,94.3,93.3,93.9,86.6,86.8,84.5,173.2,171.7,158.6,82.3,82.7,81.1,78.6,79.3,80.4,9517.3,9181.2,9417.5,9719.2,9625.7,9685.2,8934.5,8950.7,8710.6,17856.3,17706.9,16358.4,8483.2,8533,8362,8107.9,8174.7,8292.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96T88","E3 ubiquitin-protein ligase UHRF1 [OS=Homo sapiens]",20,13,20,12,793,89.8,7.56,51.88,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","UHRF1","ENSG00000276043","","DNA methylation","Pathways affected in adenoid cystic carcinoma; Malignant pleural mesothelioma",0.533,0.539,0.552,0.604,0.582,83.9,84.9,86.9,157.5,95.2,91.6,81.9,85,84,87.9,84.9,83.3,86.9,87.3,85,153.2,161.2,157.6,95.2,100.7,91.5,92.4,91.6,90.3,1288.4,1337.1,1321.1,1383.5,1336.1,1310.2,1367.3,1373.7,1337.1,2410.1,2536.2,2479.2,1497.6,1583.6,1439,1454.2,1441.7,1421,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P16989-1","Y-box-binding protein 3 [OS=Homo sapiens]",46,9,35,2,372,40.1,9.77,139.4,"stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","CSDA; YBX3","ENSG00000060138","Tight junction","","RalA downstream regulated genes; Apoptosis-related network due to altered Notch3 in ovarian cancer",0.534,0.592,0.57,0.565,0.539,84.3,93.5,90.1,157.9,89.3,85,77.9,78.6,85.5,88.3,87.2,83.8,87.9,84,80.1,147,147.3,259.7,83.2,78.3,88.7,79.3,79.3,83.9,735,741.3,806.7,833.3,822.5,790.3,829.1,792.5,755.4,1387.2,1389.2,2449.8,785.3,738.3,837,748,748.2,791.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8WZ60","Kelch-like protein 6 [OS=Homo sapiens]",8,4,5,4,621,70.3,6.29,12.33,"signal transduction;other biological processes","","","KLHL6","ENSG00000172578","","","",0.534,0.594,0.596,0.553,0.541,83.9,93.4,93.6,157.2,86.9,85,80.7,81.9,84.5,91.3,90.4,113.4,95.4,85.8,91.5,140,153.5,180,84.7,84.9,90.4,79.8,83,88.9,151.6,153.9,158.9,171.5,169.9,213,179.3,161.2,171.9,263,288.5,338.2,159.1,159.5,169.8,149.9,156,167.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8TEY7-1","Ubiquitin carboxyl-terminal hydrolase 33 [OS=Homo sapiens]",1,1,1,1,942,106.7,6.02,2.08,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","USP33","ENSG00000077254","","Ub-specific processing proteases; Regulation of expression of SLITs and ROBOs","",0.535,0.66,0.593,0.5,0.505,84.7,104.4,93.8,158.2,79,80,79.2,82.8,77.1,97.7,97.9,85.7,88.5,68.3,87.8,148.1,130.8,301.1,70.7,74,84.8,74.9,69.9,80.8,49.4,51.6,48,60.9,61,53.4,55.1,42.6,54.7,92.3,81.5,187.7,44.1,46.1,52.9,46.7,43.6,50.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8TB72-1","pumilio homolog 2 [OS=Homo sapiens]",9,9,15,5,1066,114.1,7.08,35.6,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity","PUM2","ENSG00000055917","Spinocerebellar ataxia","Neddylation","Male infertility",0.535,0.558,0.578,0.521,0.55,85.8,89.5,92.6,160.4,83.5,88.2,80.5,80.7,80,85.6,83.9,82.8,86.8,88.8,81,142.3,150.4,190.6,77.8,153.1,78.3,82.7,79.3,95.5,723,725.2,718.4,769.5,753.7,744.2,780.2,798.2,727.6,1278.3,1351.1,1712.2,698.9,1375.4,703.3,742.7,712.1,858.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q5T6S3","PHD finger protein 19 [OS=Homo sapiens]",6,3,3,3,580,65.5,8.84,8.68,"cell organization and biogenesis;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PHF19","ENSG00000119403","","PRC2 methylates histones and DNA","Genes associated with the development of rheumatoid arthritis",0.537,0.567,0.592,0.641,0.591,82,86.6,90.5,152.7,98,90.3,86.8,78.6,80.5,82.2,94.8,85,87.8,91.2,88.8,150,135.6,187.5,90.6,96.2,101.6,88.7,80.3,94,248.2,224.7,230.1,235,271.2,243.1,251.1,260.8,254,428.9,387.8,536.1,259,275.1,290.6,253.6,229.8,269,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H467","CUE domain-containing protein 2 [OS=Homo sapiens]",8,2,3,2,287,32,4.81,7.7,"other biological processes","other membranes;cytosol;nucleus","other molecular function","CUEDC2","ENSG00000107874","","","Regulation of toll-like receptor signaling pathway",0.537,0.563,0.577,0.583,0.689,81.6,85.6,87.7,151.9,88.6,104.7,79.1,93.4,79.8,83.7,87.2,76.3,85.7,80.3,88.3,137.5,148.5,185.1,96.1,86.6,84.8,102.3,100.7,104.8,181.6,214.2,183,191.9,200,175,196.5,184.1,202.6,315.4,340.6,424.7,220.5,198.6,194.4,234.7,230.9,240.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8NCN4","E3 ubiquitin-protein ligase RNF169 [OS=Homo sapiens]",9,5,5,5,708,77.1,9.1,10.27,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","RNF169","ENSG00000166439","","","",0.537,0.619,0.602,0.588,0.597,81.8,94.2,91.6,152.2,89.5,90.8,73.2,70.2,84.1,84.4,86.6,72,82,89.3,76.6,136.3,134.5,325.2,82.2,80.1,80,77.2,84.6,81.3,205.5,197,236,236.8,243.1,202.2,230.2,250.6,215,382.5,377.5,912.6,230.6,224.9,224.5,216.8,237.4,228.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8NAP3","Zinc finger and BTB domain-containing protein 38 [OS=Homo sapiens]",33,27,64,27,1195,134.2,8.03,186.3,"stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB38","ENSG00000177311","","","",0.537,0.549,0.562,0.566,0.557,85.5,87.4,89.4,159,90,88.6,87.1,86.3,87.6,91.7,88.2,89,92.2,91.1,89.9,162.1,174.4,114.4,92.6,91.8,91,90.5,90.3,90,6171.1,6115.7,6208.2,6494.8,6247.1,6308.9,6531.5,6458.5,6366.7,11484,12354.4,8103.9,6564.9,6501.8,6445.8,6414,6399.5,6374.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y6Q9-1","Nuclear receptor coactivator 3 [OS=Homo sapiens]",3,3,4,3,1424,155.2,7.47,12.25,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","NCOA3","ENSG00000124151","Endocrine resistance; Estrogen signaling pathway; Thyroid hormone signaling pathway; Pathways in cancer; Breast cancer","PPARA activates gene expression; Estrogen-dependent gene expression; Transcriptional regulation of white adipocyte differentiation; MAPK6/MAPK4 signaling; Activation of anterior HOX genes in hindbrain development during early embryogenesis","Androgen receptor signaling pathway; Integrated breast cancer pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Breast cancer pathway; EGF/EGFR signaling pathway",0.538,0.638,0.564,0.464,0.484,87.5,103.9,91.8,162.7,75.4,78.7,90.8,86.4,82.6,102.6,104.1,96,96.8,90.7,80,156.2,160.7,190.7,74,74.5,84.6,77.8,72.2,79.2,247.1,235.2,225,279.3,283.6,261.5,263.6,246.9,217.9,425.3,437.5,519.3,201.5,202.8,230.4,211.7,196.5,215.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O75691","Small subunit processome component 20 homolog [OS=Homo sapiens]",11,23,31,23,2785,318.2,7.39,92.85,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;nucleus;other cell component","","UTP20","ENSG00000120800","","rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol","",0.538,0.573,0.543,0.564,0.537,86,91.5,86.8,159.8,90.1,85.9,86.5,88.3,86.2,91.1,92.1,92.1,88.3,87.3,87.1,160.8,170.5,141.8,86.7,91.9,90.7,86.4,86.6,85.6,2708.4,2764.1,2698.1,2851.6,2884.8,2882.5,2766.1,2733.5,2726.1,5034.3,5337.5,4439.7,2715.7,2876.4,2840.2,2705.5,2711.5,2681.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q14527","Helicase-like transcription factor [OS=Homo sapiens]",3,4,7,4,1009,113.9,8.6,12.97,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HLTF","ENSG00000071794","","E3 ubiquitin ligases ubiquitinate target proteins","Retinoblastoma gene in cancer",0.539,0.615,0.564,0.605,0.575,83,94.7,86.8,153.9,93.1,88.6,81.7,79.5,80.9,92.4,94.4,88.2,84.6,84.4,90.3,150.1,143.1,195.4,91.9,84.2,90.7,86.4,85.6,96.2,457.8,445.7,453.4,517.6,529.2,494.2,474.4,473.2,506.3,841.3,801.8,1094.9,514.8,472,508.6,484,480,539.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P67809","Nuclease-sensitive element-binding protein 1 [OS=Homo sapiens]",52,12,146,9,324,35.9,9.88,604.51,"RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","YBX1","ENSG00000065978","","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; Noncanonical activation of NOTCH3","Brain-derived neurotrophic factor (BDNF) signaling pathway; MECP2 and associated Rett syndrome; mRNA processing; Sudden infant death syndrome (SIDS) susceptibility pathways",0.539,0.507,0.532,0.566,0.527,88.1,82.9,87,163.4,92.5,86.1,80,88,88.4,89.7,82.8,76.4,91.5,86.9,79.4,148,163.3,192.9,93,92.4,87.8,88.8,86.1,84.7,9331.2,10260.9,10308.3,10458.6,9653.1,8914.4,10674.3,10139.2,9263.1,17258.8,19041.6,22494.5,10846,10772.9,10240.6,10351.5,10036.9,9872.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y6H1","Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 [OS=Homo sapiens]",15,2,2,2,151,15.5,9.22,5.96,"cell organization and biogenesis;stress response;other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","CHCHD2","ENSG00000106153","","Mitochondrial protein import","",0.539,0.58,0.536,0.569,0.529,86.2,92.8,85.6,159.8,91,84.5,82.4,84.2,92,90.6,86.7,99.7,93.1,83.6,78.6,153,156.1,186.7,88.9,91,80.4,79.2,91.4,82.5,164.8,168.4,184.1,181.2,173.6,199.6,186.3,167.3,157.3,306.1,312.3,373.5,177.8,182.1,160.9,158.4,182.8,165.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q16769","glutaminyl-peptide cyclotransferase [OS=Homo sapiens]",11,2,2,2,361,40.9,6.61,9.79,"protein metabolism;other metabolic processes","non-structural extracellular;other cell component","other molecular function","QPCT","ENSG00000115828","","Neutrophil degranulation","",0.539,0.442,0.462,0.505,0.511,93.5,76.6,80.1,173.4,87.7,88.6,76.4,99.1,102.7,81.2,82.9,78.3,84.8,77.4,97.8,193.9,183.7,106.4,78.5,92.8,93.6,105.3,93.9,71.3,31.9,41.4,42.9,33.9,34.6,32.7,35.4,32.3,40.8,80.9,76.7,44.4,32.8,38.8,39.1,44,39.2,29.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q16690","Dual specificity protein phosphatase 5 [OS=Homo sapiens]",6,1,1,1,384,42,8.35,3.41,"protein metabolism;other metabolic processes;developmental processes;signal transduction","nucleus;other cell component","other molecular function","DUSP5","ENSG00000138166","MAPK signaling pathway","Negative regulation of MAPK pathway; RAF-independent MAPK1/3 activation","Endoderm differentiation; VEGFA-VEGFR2 signaling pathway",0.539,0.615,0.448,0.468,0.486,91,103.7,75.6,168.8,78.9,82,68,84.7,88.1,90.4,98,96.5,60.6,85.6,70.3,157,147.2,287.8,73.4,102.5,69.6,66.9,76.8,76.3,14.8,18.4,19.1,19.6,21.3,20.9,13.2,18.6,15.3,34.1,31.9,62.5,15.9,22.2,15.1,14.5,16.7,16.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NWK9","Box C/D snoRNA protein 1 [OS=Homo sapiens]",9,3,5,3,470,53.9,5.8,18.49,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","ZNHIT6","ENSG00000117174","","","",0.54,0.544,0.497,0.519,0.5,89.9,90.7,82.9,166.6,86.5,83.4,90.4,90.6,87.2,91.2,94.2,86.6,83.4,83.8,81.3,160.7,169.5,167.6,86.9,79.9,91.1,81.6,89.9,83.9,202.3,202.8,195.1,204.1,210.8,193.7,186.5,187.4,182,359.5,379.1,374.9,194.5,178.8,203.8,182.6,201.2,187.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96NE9-1","FERM domain-containing protein 6 [OS=Homo sapiens]",3,1,1,1,622,72,7.46,3.9,"cell organization and biogenesis","plasma membrane;other membranes;cytoskeleton;other cell component","","FRMD6","ENSG00000139926; ENSPPAG00000040522","Hippo signaling pathway; Hippo signaling pathway","","",0.54,0.501,0.52,0.455,0.473,92.9,86.1,89.4,172,78.3,81.4,99.4,88.1,93.7,86.9,100,84,91.5,79.1,90.2,174,173.5,140.1,95.2,77.5,79,89.4,82.1,76.3,58.5,51.8,55.2,51.1,58.9,49.4,53.8,46.6,53.1,102.4,102.1,82.5,56,45.6,46.5,52.6,48.3,44.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q99622","Protein C10 [OS=Homo sapiens]",26,2,3,2,126,13.2,5.14,5.97,"cell organization and biogenesis;developmental processes;other biological processes","nucleus;other cell component","","C12orf57","ENSG00000111678","","","",0.541,0.46,0.454,0.522,0.595,90.8,77.2,76.3,167.9,87.7,100,71.3,98.1,92.1,71.4,87.7,78.3,86.9,74.4,77.3,170.2,226.3,114.8,94.8,88.9,73.1,101.4,110.9,82.1,96,132.2,124.1,96.2,118.2,105.5,117.1,100.3,104.2,229.4,305,154.6,127.7,119.8,98.5,136.6,149.5,110.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NVF7-1","F-box only protein 28 [OS=Homo sapiens]",8,3,4,3,368,41.1,9.55,10.92,"protein metabolism;other metabolic processes","other cell component","other molecular function","FBXO28","ENSG00000143756; ENSGGOG00000010974; ENSPPAG00000034613; ENSPTRG00000002021","","","",0.542,0.686,0.635,0.549,0.479,83.5,105.7,98,154.2,84.7,73.8,82.7,91.7,84.4,106.9,101.6,108,91.5,99.1,103.3,155.9,173.4,119.2,82.2,85.6,85.8,74.6,80.1,73.9,148.4,164.6,151.5,191.9,182.4,193.8,164.2,177.8,185.3,279.8,311.2,213.8,147.5,153.6,153.9,133.9,143.8,132.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BT30","Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial [OS=Homo sapiens]",10,1,1,1,221,24.5,7.11,0,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","mitochondrion","other molecular function","ALKBH7","ENSG00000125652","","","",0.543,0.63,0.631,0.686,0.68,78.2,90.7,90.8,143.9,98.6,97.8,77.2,72.4,72.4,84,91.4,69,91.3,74.2,84.1,129.2,133.3,297.9,81.9,91.4,91.4,93.8,74.5,90.6,56.8,53.3,53.3,61.8,67.2,50.8,67.2,54.6,61.9,95,98.1,219.2,60.2,67.2,67.3,69,54.8,66.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96MG2","Junctional sarcoplasmic reticulum protein 1 [OS=Homo sapiens]",21,5,8,5,331,36.3,9.38,14.26,"other biological processes","other membranes;cytosol;ER/Golgi","","JSRP1","ENSG00000167476","","","",0.546,0.703,0.679,0.761,0.668,75.2,96.8,93.5,137.7,104.8,91.9,74.6,70.6,93.3,101.5,96,87.2,91.7,93.8,92.8,161,136.6,117.5,106.7,100.5,104,96.7,91.2,84.3,398.2,376.8,497.9,541.6,512.7,465.2,489.3,500.9,495.4,859.5,729.4,627.4,569.6,536.4,555.2,516,487,450,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O43791","Speckle-type POZ protein [OS=Homo sapiens]",3,1,1,1,374,42.1,5.8,3.23,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","SPOP","ENSG00000121067","Hedgehog signaling pathway","Hedgehog 'on' state","mRNA processing; Hedgehog signaling pathway",0.547,0.664,0.528,0.604,0.556,84.2,102.1,81.3,153.8,93,85.5,85.5,91.1,86,104.3,104.8,95.6,89.7,83,81.9,189.5,157.2,92.2,95,86.1,100.2,89.3,87.4,81,45.6,48.6,45.9,55.6,55.9,51,47.9,44.3,43.7,101,83.8,49.2,50.7,45.9,53.5,47.6,46.6,43.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P35790","Choline kinase alpha [OS=Homo sapiens]",2,1,1,1,457,52.2,6.55,2.76,"other metabolic processes;transport;other biological processes","cytosol","kinase activity;other molecular function","CHKA","ENSG00000110721","Glycerophospholipid metabolism; Metabolic pathways; Choline metabolism in cancer","Synthesis of PC; Synthesis of PE","Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Acetylcholine synthesis",0.549,0.636,0.506,0.618,0.531,85.8,99.3,79.1,156.3,96.6,83,85.1,95.4,83.6,106.5,98.6,98.3,75.9,78.5,89,167.4,155.1,129.2,97.9,92.4,95.9,82.3,93.3,75.5,75.4,84.5,74,94.2,87.3,87,67.2,69.5,78.7,148.2,137.3,114.4,86.7,81.8,84.9,72.9,82.6,66.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96GA3","protein LTV1 homolog [OS=Homo sapiens]",13,5,10,5,475,54.8,4.91,28.28,"transport;other biological processes","cytosol;nucleus;other cell component","","LTV1","ENSG00000135521","","Major pathway of rRNA processing in the nucleolus and cytosol","",0.549,0.587,0.54,0.543,0.51,88.4,94.5,86.8,160.9,87.3,82,86,87.2,94,93.3,99.9,92.9,90.5,85.7,85.3,143.1,158.8,177,84.6,86.2,86.9,80.5,87.3,80.9,428.4,434.6,468.4,464.8,498,463,450.9,426.9,424.9,713.3,791.2,882.1,421.8,429.3,433.2,400.9,434.8,403.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["A2AJT9-1","BCLAF1 and THRAP3 family member 3 [OS=Homo sapiens]",3,2,2,2,711,83.8,9.7,4.71,"other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","BCLAF3","ENSG00000173681","","","",0.55,0.585,0.49,0.471,0.438,93.5,99.2,83.2,169.8,79.9,74.4,98.5,88.3,89.8,85.8,97.5,95.3,90.6,76.4,80,147.6,163.1,237.8,76.8,75.7,78.3,70.1,71.4,77.1,140.3,125.7,127.9,122.2,138.8,135.8,129,108.8,113.9,210.3,232.3,338.7,109.3,107.9,111.5,99.8,101.7,109.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O14836","Tumor necrosis factor receptor superfamily member 13B [OS=Homo sapiens]",7,1,1,1,293,31.8,7.94,4.71,"developmental processes;signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","TNFRSF13B","ENSG00000240505","Cytokine-cytokine receptor interaction; Intestinal immune network for IgA production; Primary immunodeficiency","TNFs bind their physiological receptors","",0.551,0.575,0.567,0.724,0.836,77.7,81.2,80,141.1,102.1,117.9,67.4,59.2,73.3,70.4,98.1,68.1,104.1,69.4,68.4,118.7,122.4,345.5,92.7,77.3,88.6,69.9,102.3,104.4,34.5,30.3,37.5,36,50.2,34.9,53.3,35.5,35,60.8,62.7,176.9,47.4,39.6,45.4,35.8,52.4,53.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96A59","MARVEL domain-containing protein 3 [OS=Homo sapiens]",2,1,1,1,401,44.9,8.53,2.63,"cell organization and biogenesis;stress response;other biological processes","other membranes;other cell component","other molecular function","MARVELD3","ENSG00000140832","Tight junction","","",0.551,0.852,0.834,0.692,0.641,72.3,111.9,109.5,131.3,90.9,84.2,65.9,69.9,80,119.9,108.2,90.9,105.9,103.3,116.8,126.9,86.5,214.8,81.2,101.7,87.9,81.4,92.6,66.3,15.6,16.5,18.9,28.3,25.6,21.5,25,24.4,27.6,30,20.5,50.8,19.2,24,20.8,19.2,21.9,15.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96NM4-2","Isoform 2 of TOX high mobility group box family member 2 [OS=Homo sapiens]",3,2,5,1,515,54.6,7.77,11.31,"","","","TOX2","","","","",0.551,0.544,0.493,0.532,0.504,91.3,90,81.7,165.6,88,83.4,89.8,92.8,92.3,91.1,88.2,97.8,93,79,82.7,167.5,189.7,110.3,89.1,96,84.9,87.6,83.9,84.4,183.8,189.8,188.9,186.4,180.4,200,190.3,161.6,169.2,342.8,388.1,225.7,182.3,196.4,173.7,179.3,171.7,172.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P57723-1","poly(rC)-binding protein 4 [OS=Homo sapiens]",5,2,8,1,403,41.5,8.16,19.1,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","PCBP4","ENSG00000090097; ENSPTRG00000014983","","TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; FOXO-mediated transcription of cell cycle genes; Transcriptional  activation of  cell cycle inhibitor p21","",0.553,0.611,0.657,0.73,0.673,78.5,86.8,93.3,142.1,103.7,95.6,76.2,86.4,77.3,85.5,98.1,79.9,91.8,86,97.4,139,153.9,139.9,90.9,102.1,109,94.1,89.1,103.5,51.6,58.5,52.4,57.9,66.5,54.2,62.2,58.3,66,94.2,104.3,94.8,61.6,69.2,73.8,63.8,60.4,70.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P17181-1","Interferon alpha/beta receptor 1 [OS=Homo sapiens]",3,1,1,1,557,63.5,5.81,3.83,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle","other molecular function","IFNAR1","ENSG00000142166","Cytokine-cytokine receptor interaction; PI3K-Akt signaling pathway; Necroptosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; Hepatitis C; Hepatitis B; Measles; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease; Pathways in cancer","Potential therapeutics for SARS; Regulation of IFNA signaling","Osteoclast signaling; Regulation of toll-like receptor signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Immune response to tuberculosis; Regulatory circuits of the STAT3 signaling pathway; Overview of interferons-mediated signaling pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Interferon type I signaling pathways; Toll-like receptor signaling pathway",0.554,0.655,0.572,0.55,0.512,86.5,102.2,89.2,156.1,85.9,79.9,72.2,75.5,80.6,94.2,89.2,85.9,77.9,105.7,73.6,136.3,125.7,341.6,75,81,73.1,60.8,69.8,81.9,57.6,60.3,64.3,75.2,71.2,68.6,62.2,84.4,58.8,108.8,100.4,272.8,59.9,64.7,58.4,48.5,55.7,65.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y5J1","U3 small nucleolar RNA-associated protein 18 homolog [OS=Homo sapiens]",23,8,18,8,556,62,8.76,49.37,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","","UTP18","ENSG00000011260","Ribosome biogenesis in eukaryotes","rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol","",0.556,0.612,0.6,0.583,0.6,84.3,93,91.1,151.8,88.6,91.2,84.2,83.4,91.5,93.5,92.9,89.8,91.7,91,87.2,151.6,166.2,136,89.7,88.5,88.1,93.7,91,89.8,831,822.9,902.5,922.8,916.1,886.4,905,897.4,860.1,1495.9,1639.9,1342.2,884.9,872.7,869.7,924.4,898.1,886.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P20591","Interferon-induced GTP-binding protein Mx1 [OS=Homo sapiens]",4,2,3,2,662,75.5,5.83,6.94,"cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","MX1","ENSG00000157601","Hepatitis C; Measles; Influenza A; Human papillomavirus infection; Coronavirus disease","ISG15 antiviral mechanism; Interferon alpha/beta signaling","Immune response to tuberculosis; SARS-CoV-2 innate immunity evasion and cell-specific immune response",0.556,0.555,0.558,0.63,0.608,85.4,85.2,85.7,153.5,96.8,93.4,79.7,71.9,79.2,86.8,79,71.1,79.5,71.9,79.9,121.6,142.4,313.8,85.1,93.4,89.8,81.4,86.6,86.9,149.1,134.5,148,162.3,147.7,133,148.6,134.3,149.4,227.3,266.2,586.6,159.2,174.7,167.8,152.2,161.9,162.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9P2D1-1","Chromodomain-helicase-DNA-binding protein 7 [OS=Homo sapiens]",4,10,12,5,2997,335.7,6.34,23.27,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","CHD7","ENSG00000171316","","","Kallmann syndrome",0.557,0.589,0.551,0.565,0.543,87.8,92.8,86.9,157.7,89.2,85.7,83.3,84.7,77.5,93.4,81.2,88.1,77.8,85.3,82.4,139,149.6,275.5,86.5,79,84.6,69,82,81.3,79.2,80.6,73.7,88.9,77.3,83.8,74,81.1,78.4,132.3,142.4,262.2,82.3,75.1,80.5,65.7,78,77.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6ZVF9","G protein-regulated inducer of neurite outgrowth 3 [OS=Homo sapiens]",23,13,20,13,776,82.4,7.56,69.33,"cell organization and biogenesis;developmental processes","plasma membrane;other membranes","","GPRIN3","ENSG00000185477","","","",0.557,0.564,0.563,0.562,0.524,88.6,89.7,89.6,159.2,89.4,83.4,85.6,88.7,90.9,94.1,89.9,88.6,90.7,89.7,88.1,149,159.4,165.9,91.4,89.5,89,81.2,83.5,84.7,1574.5,1632.1,1672.2,1731.1,1652.5,1629.9,1667.9,1650.5,1620.3,2739.6,2930.8,3050.3,1680.3,1646.8,1637.4,1493.5,1535.7,1558,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NSP4-1","Centromere protein M [OS=Homo sapiens]",4,1,2,1,180,19.7,7.2,4.9,"","cytosol;nucleus;other cell component","","C22orf18; CENPM","ENSCANG00000032088; ENSG00000100162; ENSPPAG00000037196; ENSPPYG00000011884; ENSPTRG00000014442","","Separation of Sister Chromatids; Deposition of new CENPA-containing nucleosomes at the centromere; RHO GTPases Activate Formins; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",0.557,0.585,0.641,0.591,0.753,81,85,93.2,145.4,85.9,109.5,82.7,86.1,93,93.8,88.8,90.4,99.2,96.2,111.8,155.7,154.7,21.3,91.4,90.4,97.1,112.8,118.3,116.5,216.9,225.9,243.8,245.9,232.9,237.2,260.2,252.3,293.2,408.3,405.6,55.9,239.6,237,254.7,295.7,310.3,305.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q14865","AT-rich interactive domain-containing protein 5B [OS=Homo sapiens]",2,1,1,1,1188,132.3,8.72,0,"other metabolic processes;developmental processes;signal transduction;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ARID5B","ENSG00000150347","","HDMs demethylate histones","Mesodermal commitment pathway; FTO obesity variant mechanism; Pathways affected in adenoid cystic carcinoma",0.558,0.501,0.526,0.6,0.528,90.2,81,84.9,161.6,97,85.3,72.6,84.5,89.5,68.2,96.8,75.8,84.5,76.3,79.6,116.1,151.4,295.9,90.9,80.8,99.5,73.4,79.9,84.2,31,36.1,38.3,29.1,41.4,32.4,36.1,32.6,34,49.6,64.7,126.5,38.9,34.6,42.5,31.4,34.2,36,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BSK4","Protein fem-1 homolog A [OS=Homo sapiens]",2,1,1,1,669,73.6,6.07,2.05,"protein metabolism;other metabolic processes;other biological processes","cytosol;mitochondrion;other cell component","signal transduction activity or receptor binding;other molecular function","FEM1A","ENSG00000141965","","Neddylation","",0.56,0.646,0.542,0.544,0.472,89.2,102.9,86.4,159.4,86.8,75.2,90.1,77.8,94.5,89.4,103.9,108,87.3,92,87.3,178.1,131.1,161,95.7,87.6,83.6,75.9,70.2,86.7,51.2,44.2,53.7,50.8,59.1,61.4,49.6,52.3,49.6,101.3,74.5,91.5,54.4,49.8,47.5,43.2,39.9,49.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P41236","Protein phosphatase inhibitor 2 [OS=Homo sapiens]",31,5,10,5,205,23,4.74,33.84,"other metabolic processes;other biological processes","","enzyme regulator activity","PPP1R2","ENSG00000184203","","","",0.56,0.809,0.971,0.965,0.616,68.3,98.6,118.4,121.9,117.7,75.1,67.9,63.3,133.8,112.6,98.1,71.9,117.8,121.7,103.4,121.2,76.4,131.5,120.7,86.4,117,120.6,74.7,61.1,721.1,671.9,1421.6,1196.1,1041.4,764,1250.8,1292.3,1098.7,1287.8,811.1,1396.3,1281.7,918,1242.8,1280.5,793,649.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q14145","Kelch-like ECH-associated protein 1 [OS=Homo sapiens]",8,5,7,5,624,69.6,6.44,18.3,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","KEAP1","ENSG00000079999","Ubiquitin mediated proteolysis; Parkinson disease; Pathways in cancer; Chemical carcinogenesis; Hepatocellular carcinoma; Fluid shear stress and atherosclerosis","Ub-specific processing proteases; Antigen processing: Ubiquitination & Proteasome degradation; Potential therapeutics for SARS; ROS sensing by NFE2L2; Neddylation","Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; NRF2-ARE regulation; Head and neck squamous cell carcinoma; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway",0.561,0.62,0.569,0.617,0.651,83.7,92.5,84.9,149.4,92.1,97.3,85.8,86,88.9,95.1,87.8,96,87.3,99.2,85.9,159,153.5,94.1,91,96.6,94.7,95.3,104,99.9,369.3,370.2,382.8,409.1,377.8,413,375.6,427,369.7,684.1,660.4,405,391.5,415.6,407.4,410.1,447.5,430.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8N5H7-1","SH2 domain-containing protein 3C [OS=Homo sapiens]",4,3,6,3,860,94.4,8.07,15.68,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","enzyme regulator activity;other molecular function","SH2D3C","ENSG00000095370","","","",0.561,0.677,0.593,0.584,0.611,83.7,100.9,88.3,149,87.1,91,75.2,80.5,83,98.1,97.2,91,82.1,88.2,85,139.9,143.5,231.9,83.8,82.7,85.3,74.6,87.6,90.2,413.1,442.7,456.4,539.4,534.1,500.1,451.4,484.8,467.3,769,788.7,1274.8,460.8,454.7,469,409.9,481.7,495.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q7Z614-1","Sorting nexin-20 [OS=Homo sapiens]",4,1,1,1,316,36.2,8.65,2.64,"transport","plasma membrane;other membranes;nucleus;other cytoplasmic organelle","other molecular function","SNX20","ENSG00000167208","","","",0.562,0.685,0.65,0.604,0.587,82.5,100.6,95.4,146.7,88.6,86.2,74,79.3,74.6,104.7,86.2,91,87.7,80.6,86.3,103.2,132.8,307.7,80.2,68.4,87.1,78,77.7,100.8,43.1,46.2,43.5,61,50.3,53.1,51.1,47,50.4,60.2,77.4,179.4,46.8,39.9,50.8,45.5,45.3,58.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q99633-1","Pre-mRNA-splicing factor 18 [OS=Homo sapiens]",24,5,8,5,342,39.8,8.15,28.88,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","","Prpf18; PRPF18","ENSCPOG00000021069; ENSG00000165630; ENSLAFG00000007753; ENSMFAG00000000540; ENSMMUG00000015071; ENSMNEG00000024679; ENSNLEG00000012186; ENSPPAG00000041959; ENSPTRG00000002306","Spliceosome","","mRNA processing; mRNA Processing",0.562,0.608,0.548,0.558,0.566,87.8,94.9,85.6,156.2,87.2,88.4,91,89.7,85.9,88.3,102.7,97,93,85.4,87.5,159.6,173.7,101.3,95.4,83.8,89.2,88.2,98,90.3,291.9,288,275.6,283.2,329.7,311.2,298.4,274,280.7,512.3,557.3,325,306.3,269,286.1,283,314.4,289.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UNL4-1","inhibitor of growth protein 4 [OS=Homo sapiens]",8,2,2,2,249,28.5,7.62,5.4,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","ING4","ENSCATG00000030917; ENSCJAG00000008004; ENSCSAG00000010403; ENSG00000111653; ENSMLEG00000028668; ENSMNEG00000038607; ENSPANG00000008024; ENSRBIG00000029015","","HATs acetylate histones","",0.563,0.582,0.482,0.49,0.56,91.9,94.9,78.6,163.2,80,91.4,93.1,91.7,96.2,96.1,119.4,87.7,97.5,78.5,79.6,174.4,165.2,105.5,77,81,82.1,94.7,87.7,92.6,185.7,182.9,191.9,191.7,238.2,174.9,194.4,156.6,158.8,348,329.7,210.5,153.5,161.6,163.9,189,175,184.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q15906","vacuolar protein sorting-associated protein 72 homolog [OS=Homo sapiens]",8,3,3,3,364,40.6,6.48,9.33,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","VPS72","ENSG00000163159","","HATs acetylate histones","",0.565,0.687,0.768,0.697,0.664,77.4,94.1,105.2,137,95.5,90.9,74.3,77.7,109,94.5,95.1,85.4,105.7,112.3,91.8,149.3,111.2,137.6,95.9,88.3,98.5,104.9,91.3,77.3,234.5,245.3,344,298.3,300.2,269.6,333.6,354.5,289.6,471.1,351.1,434.2,302.8,278.6,310.8,331.2,288.1,244.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y2P8","RNA 3'-terminal phosphate cyclase-like protein [OS=Homo sapiens]",12,4,9,4,373,40.8,9.26,27.7,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","RCL1","ENSG00000120158","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",0.566,0.615,0.558,0.511,0.513,90.2,98.1,88.9,159.5,81.5,81.8,96.1,90.2,92.4,95.5,103.1,100.5,75.1,91.1,91.4,174.2,163.4,119.5,82.6,83.5,91.6,83.9,83.8,82.3,953.2,894.9,916.6,947,1022.8,997.2,744.8,903.6,906.8,1728.1,1620.6,1185.2,819.2,828.1,908.4,831.9,831.3,816.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6W2J9-1","BCL-6 corepressor [OS=Homo sapiens]",2,3,3,3,1755,192.1,6.48,9.87,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","BCOR","ENSG00000183337","","","Ectoderm differentiation; Pathways affected in adenoid cystic carcinoma; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma",0.566,0.65,0.599,0.587,0.533,86.3,99.1,91.3,152.4,89.5,81.3,95.9,79.7,84.5,94.4,97,98,83.3,89.4,93.8,138.3,149.2,201.8,80.8,87.6,89.5,79.7,77.4,79.6,170.6,141.6,150.3,167.9,172.5,174.2,148.2,158.9,166.8,245.9,265.3,358.8,143.6,155.8,159.1,141.7,137.6,141.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O00470","Homeobox protein Meis1 [OS=Homo sapiens]",2,1,1,1,390,43,6.33,2.92,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MEIS1","ENSG00000143995","Signaling pathways regulating pluripotency of stem cells; Transcriptional misregulation in cancer","Activation of anterior HOX genes in hindbrain development during early embryogenesis","Mesodermal commitment pathway",0.568,0.509,0.517,0.531,0.587,91.8,82.3,83.6,161.6,85.8,94.9,85.9,90.1,99.6,89.1,76.2,80.8,68.4,101.6,82.1,158.6,185,156.1,100.9,84.2,70.9,96.2,81,93.2,28.7,30.1,33.3,29.8,25.5,27,22.9,34,27.4,53,61.9,52.2,33.7,28.2,23.7,32.2,27.1,31.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9ULR0-1","Isoform 2 of Pre-mRNA-splicing factor ISY1 homolog [OS=Homo sapiens]",5,2,2,2,331,37.5,5.78,4.5,"","","","ISY1","","","","",0.568,0.511,0.656,0.587,0.567,87.6,78.8,101.2,154.3,90.6,87.5,75.4,78.9,90.1,70.9,55.6,98.1,91.1,79.5,98.5,131.7,138.9,292.8,81.5,72.2,87.1,78.8,113.6,65.1,155.1,162.4,185.5,146,114.4,201.8,187.6,163.6,202.6,271.1,285.8,602.6,167.8,148.7,179.2,162.2,233.9,133.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9HC44","Vasculin-like protein 1 [OS=Homo sapiens]",4,1,1,1,474,52.3,6.84,3.8,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity","GPBP1L1","ENSG00000159592","","","",0.569,0.66,0.526,0.553,0.449,90.8,105.4,84,159.7,88.3,71.8,78.9,101.8,90.5,105,123.5,101.8,83.7,78.8,94.4,159.1,115.1,189.2,90.8,78.9,88,71.5,81.4,67.4,41.9,54,48,55.7,65.5,54,44.4,41.8,50.1,84.4,61,100.3,48.1,41.9,46.7,37.9,43.1,35.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P31785-1","Cytokine receptor common subunit gamma [OS=Homo sapiens]",9,3,8,3,369,42.3,6.34,23.65,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","IL2RG","ENSG00000147168","Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor; Endocytosis; PI3K-Akt signaling pathway; JAK-STAT signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; Measles; Human T-cell leukemia virus 1 infection; Pathways in cancer; Inflammatory bowel disease; Primary immunodeficiency","Interleukin receptor SHC signaling; RAF/MAP kinase cascade; Interleukin-4 and Interleukin-13 signaling; Interleukin-7 signaling; Interleukin-2 signaling; Interleukin-15 signaling; Interleukin-9 signaling; Interleukin-21 signaling; STAT3 nuclear events downstream of ALK signaling","IL-7 signaling pathway; IL-9 signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PI3K-Akt signaling pathway; Inflammatory response pathway; Interactions between immune cells and microRNAs in tumor microenvironment; IL-2 signaling pathway",0.57,0.619,0.646,0.611,0.653,83.4,90.6,94.5,146.4,89.5,95.6,80.8,80,81.8,92.1,81.1,87.7,91.5,96.6,90.8,130.1,141.7,203.5,86.7,91.9,86,92.6,92.4,92.8,608.4,602.6,616,693.4,610.7,660.6,689.5,727.3,683.9,979.8,1067.5,1532.7,652.7,692.6,648,697.1,696.3,698.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BR61","Acyl-CoA-binding domain-containing protein 6 [OS=Homo sapiens]",10,2,2,2,282,31.1,5.11,6.25,"","cytosol","other molecular function","ACBD6","ENSG00000230124","","Mitochondrial Fatty Acid Beta-Oxidation","",0.57,0.482,0.496,0.522,0.53,95,80.3,82.7,166.7,87,88.3,92.7,93.2,79.8,72.7,78.4,84.5,80.7,79.9,86,162.6,161.9,213.4,87.3,84.8,80.5,86.2,97,78.5,113.2,113.8,97.4,88.8,95.7,103.2,98.5,97.6,105,198.6,197.7,260.6,106.6,103.6,98.3,105.2,118.5,95.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96B01","RAD51-associated protein 1 [OS=Homo sapiens]",2,1,2,1,352,38.4,9.11,4.68,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity","RAD51AP1","ENSG00000111247","","Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Homologous DNA Pairing and Strand Exchange; Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function","",0.57,0.573,0.588,0.591,0.562,88.1,88.6,90.8,154.5,91.2,86.8,91.9,87.6,86.3,93.7,80.4,88,73.3,102.2,90.2,117.6,153.5,203.1,92.9,89.6,90.7,84.2,88.3,86.3,166.2,158.4,156.1,169.5,145.5,159.3,132.6,184.8,163.2,212.6,277.7,367.4,168.1,162.1,164,152.2,159.8,156.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q13573","SNW domain-containing protein 1 [OS=Homo sapiens]",23,10,21,10,536,61.5,9.52,54.24,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","SNW1","ENSG00000100603","Spliceosome; Notch signaling pathway; Epstein-Barr virus infection; Viral carcinogenesis","Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; mRNA Splicing - Major Pathway; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Pre-NOTCH Transcription and Translation; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling","TGF-beta signaling pathway; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Splicing factor NOVA regulated synaptic proteins; Notch signaling pathway (Netpath)",0.571,0.779,0.76,0.756,0.627,76.3,104.1,101.5,133.5,100.9,83.7,72.7,66.6,109.4,116.3,99.2,92.4,96.7,101.7,87.4,178.8,127.3,114.6,106.4,95.5,96.2,94.4,79.8,64.3,1384.7,1268.2,2083.8,2213.9,1889.5,1759.4,1842.1,1935.7,1664.6,3404.4,2424.5,2181.6,2026.4,1818.4,1832.1,1796.9,1520.1,1225.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9P0B6","Coiled-coil domain-containing protein 167 [OS=Homo sapiens]",30,3,4,3,97,11.5,9.5,10.28,"","other membranes","","CCDC167","ENSG00000198937","","","",0.571,0.638,0.657,0.699,0.76,79.2,88.5,91.2,138.7,96.9,105.4,78.1,87.6,79.3,88.5,86.2,91.6,91.2,90.7,93.9,129.5,138.8,140.3,96.3,108.6,97,88.6,105.5,108.5,472.9,531,480.4,536.4,522,554.7,552.8,549.3,568.7,784.9,841,850.3,583.3,657.9,587.7,536.7,638.9,657.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P00519","Tyrosine-protein kinase ABL1 [OS=Homo sapiens]",1,1,1,1,1130,122.8,8.66,0,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;kinase activity;other molecular function","ABL1","ENSG00000097007","ErbB signaling pathway; Ras signaling pathway; Cell cycle; Axon guidance; Neurotrophin signaling pathway; Pathogenic Escherichia coli infection; Pathways in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chronic myeloid leukemia; Viral myocarditis","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Factors involved in megakaryocyte development and platelet production; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RHO GTPases Activate WASPs and WAVEs; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Myogenesis; Cyclin D associated events in G1; RUNX2 regulates osteoblast differentiation; HDR through Single Strand Annealing (SSA); Role of ABL in ROBO-SLIT signaling","miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; TP53 network; Cell cycle; Integrated breast cancer pathway; Microtubule cytoskeleton regulation; Pathogenic Escherichia coli infection; Retinoblastoma gene in cancer; ATM signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Imatinib and chronic myeloid leukemia; VEGFA-VEGFR2 signaling pathway; Ras signaling; Acute viral myocarditis; EGF/EGFR signaling pathway; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)",0.572,0.514,0.542,0.533,0.691,89.1,80,84.5,155.7,83,107.6,88.1,83.1,94.9,106.2,76.4,79.1,129.8,83.4,66.7,122.3,153.8,167.9,95,82,80.9,109.4,106.3,74.7,23.5,22.2,25.3,28.3,20.4,21.1,34.6,22.2,17.8,32.6,41,44.8,25.3,21.9,21.6,29.2,28.3,19.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NXE8","pre-mRNA-splicing factor CWC25 homolog [OS=Homo sapiens]",8,3,4,3,425,49.6,10.18,12.59,"RNA metabolism OR transcription;other metabolic processes","nucleus","","CWC25","ENSG00000273559; ENSG00000276761","","mRNA Splicing - Major Pathway","",0.574,0.575,0.537,0.593,0.545,90,90.2,84.3,156.9,93,85.6,81.1,80.5,84.6,81.3,118.1,79,75.2,76,76.9,141.4,126,295.5,82.1,85.7,83.9,74.3,77.1,81.4,377.7,374.8,393.9,378.5,550.1,367.6,350.2,353.8,358,658.4,586.8,1375.7,382.1,399.2,390.4,346,359.1,379,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q09327","Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase [OS=Homo sapiens]",8,3,3,3,533,61.3,8.28,8.11,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi","other molecular function","MGAT3","ENSG00000128268","N-Glycan biosynthesis; Metabolic pathways","Reactions specific to the hybrid N-glycan synthesis pathway","",0.574,0.623,0.577,0.592,0.616,86.5,93.9,87,150.7,89.2,92.8,86.2,86.4,89.3,103.3,75.3,93.8,86.7,86.9,95.4,150.5,183.4,117.3,89.1,89.8,86.7,92.8,94.9,92.3,134.9,135.1,139.7,161.6,117.8,146.8,135.5,136,149.2,235.5,286.9,183.4,139.4,140.4,135.6,145.1,148.5,144.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8WW01","tRNA-splicing endonuclease subunit Sen15 [OS=Homo sapiens]",11,1,1,1,171,18.6,4.58,2.71,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","TSEN15","ENSG00000198860","","tRNA processing in the nucleus","",0.576,0.54,0.548,0.643,0.545,89.6,84.2,85.4,155.7,100.1,84.9,82.6,84.5,80,70.8,81.4,77.5,78.7,63,92.1,140.6,143.5,313.9,92.3,93.4,58.3,76.2,93,78.3,28,28.6,27.1,24,27.6,26.3,26.6,21.3,31.2,47.6,48.6,106.3,31.3,31.6,19.7,25.8,31.5,26.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8NDV7","Trinucleotide repeat-containing gene 6A protein [OS=Homo sapiens]",1,2,3,1,1962,210.2,7.01,3.4,"stress response;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","","TNRC6A","ENSG00000090905; ENSG00000288130","","Transcriptional regulation by small RNAs; MAPK6/MAPK4 signaling; Oxidative Stress Induced Senescence; Estrogen-dependent gene expression; TP53 Regulates Metabolic Genes; Ca2+ pathway; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Pre-NOTCH Transcription and Translation; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Regulation of RUNX1 Expression and Activity; Post-transcriptional silencing by small RNAs; Competing endogenous RNAs (ceRNAs) regulate PTEN translation","",0.576,0.485,0.624,0.559,0.516,92,77.4,99.6,159.6,89.1,82.3,92.4,93.5,84.7,82.1,70.7,77.7,100.6,100,88.9,180.6,149.9,160.3,75.3,90.3,89.5,115.7,82.7,65.2,28.2,28.5,25.8,25,21.6,23.7,30.7,30.5,27.1,55.1,45.7,48.9,23,27.5,27.3,35.3,25.2,19.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8IWC1","MAP7 domain-containing protein 3 [OS=Homo sapiens]",9,8,12,7,876,98.4,9.32,26.14,"cell organization and biogenesis","cytoskeleton;other cell component","cytoskeletal activity","MAP7D3","ENSG00000129680","","","",0.577,0.574,0.554,0.592,0.573,89.5,89,85.9,155,91.8,88.9,98.6,87.8,89.3,88.8,83.2,91.1,83.6,90.3,85.7,148.8,159.1,154.8,99.2,91.6,84.1,91.9,88.7,83.5,1138.8,1014.4,1031.4,1025.6,960.4,1052.2,965.7,1042.5,989.9,1718.1,1837,1787.5,1145.4,1058.2,971.3,1061.4,1024.6,964,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UGN4-1","CMRF35-like molecule 8 [OS=Homo sapiens]",13,3,4,3,299,33.2,5.49,12.49,"cell adhesion;other biological processes","plasma membrane;other membranes","other molecular function","CD300A","ENSG00000167851","","Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell","Ebola virus pathway in host",0.577,0.703,0.675,0.683,0.626,81.2,98.9,95,140.7,96.1,88.1,89.1,77.6,79.9,97.3,98,81.3,110.9,93.5,83.3,138.4,127.2,172.3,88.6,95.2,94.6,86.7,83.7,102.5,257.2,224,230.8,281.1,283.1,234.6,320.1,270,240.5,399.7,367.3,497.6,255.9,275,273.1,250.3,241.6,295.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NYH9","U3 small nucleolar RNA-associated protein 6 homolog [OS=Homo sapiens]",20,10,15,10,597,70.1,7.28,50.5,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","UTP6","ENSG00000108651","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",0.578,0.652,0.566,0.588,0.565,87.8,99.1,85.9,152,89.4,85.9,88.7,89.7,88,95.3,107.3,100.1,85.8,88.5,86.8,162.3,153.6,127,90.3,86.6,90.4,85.4,86.8,87.2,1147.1,1160.2,1137.6,1232.9,1388,1294.7,1110.1,1145.2,1123.3,2099.6,1986.2,1642.5,1167.8,1120.5,1169.9,1104.6,1122.8,1128.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H6R0-1","Putative ATP-dependent RNA helicase DHX33 [OS=Homo sapiens]",11,6,6,6,707,78.8,8.91,16.26,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","translation activity;nucleic acid binding activity;other molecular function","DHX33","ENSG00000005100","NOD-like receptor signaling pathway","","",0.578,0.671,0.608,0.61,0.635,84.5,98.1,88.9,146.3,89.3,92.9,93,87.8,86.3,101.9,102.2,97.9,92.3,91.4,92.5,152.2,151.9,89,97.5,89.8,92.7,96.9,88.4,96.5,456.6,430.8,423.7,500.3,501.5,480.5,453.3,448.8,454,747.1,745.6,437,478.9,440.6,455.1,475.7,433.9,473.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q5H9L2","Transcription elongation factor A protein-like 5 [OS=Homo sapiens]",4,1,1,1,206,23.3,4.81,2.05,"","nucleus","other molecular function","TCEAL5","ENSG00000204065","","","",0.578,0.771,1.194,0.994,0.75,65.6,87.5,135.5,113.5,112.8,85.1,62.7,48.9,156.5,94.8,83.6,68.7,130.4,125,129.6,108.5,79.4,110.7,107.9,89.9,120.6,136,65.2,81.4,46.5,36.3,115.9,70.2,62,50.9,96.6,92.6,96,80.4,58.8,82,79.9,66.6,89.4,100.7,48.3,60.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NUQ6","SPATS2-like protein [OS=Homo sapiens]",27,15,22,1,558,61.7,9.64,49.9,"","cytosol;nucleus;other cell component","","SPATS2L","ENSG00000196141","","","",0.579,0.566,0.535,0.537,0.581,91.5,89.4,84.5,158,84.9,91.7,91.3,95.2,93.8,84.7,91.6,97.4,85.2,88,86.7,166.8,162,119.3,91.3,86.5,87.1,94.1,94.3,84.5,2056.2,2143.7,2112.7,1908,2063.5,2194.1,1918.2,1981.7,1952.2,3755.4,3648.6,2687.3,2055.2,1947.5,1960.7,2118.6,2122.7,1902.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96J42-1","Thioredoxin domain-containing protein 15 [OS=Homo sapiens]",14,2,6,2,360,39.9,4.83,13.45,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;other cell component","","TXNDC15","ENSG00000113621","","","Genes related to primary cilium development (based on CRISPR)",0.58,0.719,0.666,0.691,0.638,81,100.4,93.1,139.7,96.6,89.2,75.3,89.5,75.6,98.2,93.7,73.4,91.3,86.9,86.8,120.5,130.4,263,96.2,90.1,84.2,85.3,76.5,83.2,100.9,119.8,101.2,131.6,125.5,98.3,122.3,116.4,116.2,161.4,174.6,352.2,128.8,120.7,112.8,114.3,102.4,111.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P36508","Zinc finger protein 76 [OS=Homo sapiens]",4,3,3,1,570,61.8,6.05,6.06,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF76","ENSG00000065029","","","3q29 copy number variation syndrome",0.58,0.496,0.62,0.637,0.665,87,74.4,93.1,150.1,95.5,99.8,74.9,80.8,82.1,69.1,81.2,52.6,87.9,83.1,86.4,139.3,126.1,278.4,88.7,80,107.6,90.7,92.6,98.5,55.7,60.1,61.1,51.4,60.4,39.2,65.4,61.8,64.3,103.6,93.7,207,65.9,59.5,80,67.4,68.9,73.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9ULX3","RNA-binding protein NOB1 [OS=Homo sapiens]",30,10,13,10,412,46.6,7.18,42.49,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","NOB1","ENSG00000141101","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol","",0.581,0.623,0.569,0.586,0.558,89,95.4,87.2,153.2,89.7,85.4,89.1,87.1,92.7,98.6,92.5,95.5,92.8,87.3,86,160.5,153.3,135.3,89.8,90.6,88.8,89.8,85,85.5,1324,1294.3,1377.4,1464.6,1374,1419.4,1378.5,1296.8,1277.9,2385.1,2278,2011.1,1334.3,1346.7,1319.8,1333.8,1263.4,1270.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NPF0","CD320 antigen [OS=Homo sapiens]",16,5,12,5,282,29,4.75,30.11,"other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","signal transduction activity or receptor binding;other molecular function","CD320","ENSG00000167775","","Cobalamin (Cbl, vitamin B12) transport and metabolism; Defective CD320 causes MMATC","",0.582,0.536,0.608,0.704,0.723,84.1,77.4,87.8,144.5,101.7,104.4,86.5,84.5,85.4,77.8,78.5,83.2,94.7,85.8,89.1,146.6,159.1,100.6,105.3,102.9,103.2,106.6,105.9,104.2,912.5,892.2,900.9,821.3,828.9,878.2,999.4,905.5,940.7,1547,1679.6,1061.4,1111.5,1085.6,1089.6,1125.3,1117.9,1099.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O60427","Fatty acid desaturase 1 [OS=Homo sapiens]",2,1,1,1,444,51.9,8.87,2.12,"cell-cell signaling;other metabolic processes;stress response;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","FADS1","ENSG00000149485","Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism","PPARA activates gene expression; alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Linoleic acid metabolism affected by coronavirus infection",0.583,0.596,0.677,0.671,0.682,83.1,85,96.5,142.5,95.7,97.2,83.4,85.7,82.1,92.9,80.9,85.2,99.1,96.8,94.4,134.8,142.9,154.1,98.9,95.9,91.1,97.5,98.7,85.6,226.9,233.2,223.4,252.9,220.1,231.9,269.8,263.5,257,367,389,419.4,269.2,261.1,247.9,265.3,268.6,233.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O95166","Gamma-aminobutyric acid receptor-associated protein [OS=Homo sapiens]",6,1,1,1,117,13.9,8.79,2.91,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","GABARAP","ENSG00000170296","FoxO signaling pathway; Autophagy; Mitophagy; Autophagy; NOD-like receptor signaling pathway; GABAergic synapse","Macroautophagy; TBC/RABGAPs","Senescence and autophagy in cancer",0.583,0.511,0.469,0.488,0.576,96.5,84.5,77.6,165.4,80.7,95.3,101.1,103,79.9,88.5,70.7,94.8,80.8,81.3,91.2,173.3,182.4,60.6,95,84.6,73.4,99.9,144.5,95,136.1,138.7,107.6,119.2,95.2,127.6,108.8,109.4,122.8,233.3,245.6,81.6,127.9,113.9,98.8,134.5,194.6,127.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y6C2","EMILIN-1 [OS=Homo sapiens]",4,3,3,3,1016,106.6,5.15,9.3,"","","","","","","","",0.584,0.65,0.7,0.701,0.679,81.2,90.4,97.4,139.1,97.6,94.4,80.6,77.3,79.1,88,93.6,87.3,94.9,90.1,97.7,134.5,135.5,192.8,95,79.2,98.2,95.9,88.4,92,286.3,274.5,280.8,312.5,332.5,310.1,336.9,319.8,346.9,477.6,481,684.7,337.4,281.3,348.7,340.4,313.8,326.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P06454-1","Prothymosin alpha [OS=Homo sapiens]",23,6,48,6,111,12.2,3.78,153.78,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","PTMA","ENSCATG00000024952; ENSCCAG00000025294; ENSG00000187514; ENSGGOG00000009874; ENSMFAG00000031087; ENSMMUG00000012140; ENSMNEG00000029751; ENSNLEG00000014135; ENSRROG00000033267","","","VEGFA-VEGFR2 signaling pathway",0.584,0.828,1.003,1.084,0.736,67,94.9,114.9,114.6,124.2,84.4,64.1,53.3,139.1,127.6,90.8,71.7,110,131.6,91.1,141.8,109.6,51.6,120.5,114.8,118.9,119.8,80.7,63,4153.3,3455.9,9019.4,8272.6,5887.7,4646.2,7129.5,8529.1,5903.5,9194.4,7107.8,3344,7815.4,7443.1,7705.5,7769.5,5232.7,4087.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P11474-1","Steroid hormone receptor ERR1 [OS=Homo sapiens]",11,3,3,3,423,45.5,6.38,10.33,"developmental processes;signal transduction;other biological processes","non-structural extracellular;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","ESRRA","ENSG00000173153; ENSPANG00000024911; ENSPPYG00000003107","","PPARA activates gene expression; Regulation of RUNX2 expression and activity; Transcriptional activation of mitochondrial biogenesis; Nuclear Receptor transcription pathway","Energy metabolism; Nuclear receptors; Pre-implantation embryo; Mitochondrial gene expression",0.585,0.529,0.647,0.545,0.57,90.5,81.8,100.2,154.8,84.3,88.3,93.1,84.1,81.4,104.5,76,68.4,105.9,93.1,87.5,115.7,143.8,241.5,76.6,94.6,78.3,76.7,96.9,82,53.5,48.3,46.8,60,43.7,39.3,60.8,53.4,50.2,66.5,82.6,138.7,44,54.4,45,44.1,55.6,47.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8NCH0","Carbohydrate sulfotransferase 14 [OS=Homo sapiens]",4,2,2,2,376,43,9.48,2.05,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","CHST14","ENSG00000169105","Glycosaminoglycan biosynthesis","Dermatan sulfate biosynthesis; Defective CHST14 causes EDS, musculocontractural type","Proteoglycan biosynthesis; Metapathway biotransformation Phase I and II",0.586,0.516,0.561,0.629,0.554,91.4,80.6,87.5,156,98.2,86.4,83.5,83.6,76.2,69.6,79.9,73.7,80,78.2,86.1,142.6,133.1,312,77.3,92,89.8,78.7,79,84.7,120.1,120.2,109.6,100.1,114.9,105.9,115,112.4,123.8,205,191.3,448.6,111.1,132.3,129.1,113.1,113.6,121.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["A0AV96","RNA-binding protein 47 [OS=Homo sapiens]",22,9,24,9,593,64.1,7.68,76.54,"RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus","nucleic acid binding activity","RBM47","ENSG00000163694","","","TYROBP causal network in microglia",0.587,0.654,0.612,0.616,0.607,86.4,96.3,90.1,147.2,90.7,89.3,87.9,87.3,87.2,94.2,101,97.3,91.5,91,87.5,148.8,131,151.1,93,90.1,91.7,87.7,90.3,91.5,1434.2,1423.7,1423,1536.6,1648.1,1586.8,1492,1484.8,1427.6,2427.4,2137.3,2465,1517.9,1470,1495.4,1430.6,1472.7,1492.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6NTE8-2","Isoform 2 of MRN complex-interacting protein [OS=Homo sapiens]",10,2,2,2,271,29.4,5.57,6.46,"","","","MRNIP","","","","",0.587,0.686,0.661,0.641,0.626,83.8,98,94.4,142.8,91.6,89.3,83.1,82.6,72.6,107.5,96.6,77.9,98.7,93,90.9,140.7,115.8,200.7,98.2,86.8,90.3,93.2,88,83.3,75.1,74.7,65.7,97.2,87.3,70.4,89.2,84.1,82.2,127.2,104.7,181.5,88.8,78.5,81.6,84.3,79.6,75.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q5QJE6","Deoxynucleotidyltransferase terminal-interacting protein 2 [OS=Homo sapiens]",25,13,23,13,756,84.4,6.16,62.91,"","nucleus;other cell component","","DNTTIP2","ENSG00000067334","","","",0.588,0.606,0.58,0.592,0.564,89.7,92.6,88.6,152.7,90.3,86.1,88.5,91.8,87,94.9,91.3,88.5,87.3,89.8,87.4,136.1,150.6,180,87.1,94.2,89.1,85,84.7,86.9,1258.2,1304.6,1237,1349,1298,1257.2,1240.2,1275.9,1241.8,1933.7,2140.3,2558,1238.5,1338.4,1266.1,1207.4,1203.2,1235.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8WWB7","Glycosylated lysosomal membrane protein [OS=Homo sapiens]",2,1,1,1,406,43.8,6.58,2.34,"other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle","","GLMP","ENSG00000198715","","","",0.588,0.485,0.61,0.572,0.531,93.2,76.9,96.7,158.5,90.7,84.1,84.4,96.2,73.3,121.3,69.6,43,103.1,82.2,87.6,73.9,143.5,295,125,82.1,76,99,76.2,68.5,85.7,97.7,74.4,123.2,70.7,43.6,104.7,83.5,88.9,75.1,145.8,299.6,127,83.4,77.2,100.5,77.4,69.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8NDD1","Uncharacterized protein C1orf131 [OS=Homo sapiens]",4,1,1,1,294,32.7,9.92,3.21,"","","","","","","","",0.588,0.593,0.596,0.658,0.535,88.9,89.7,90.1,151.1,99.5,80.8,75.5,92.8,99.2,76.6,101.2,93.6,94,101.1,89.3,144.3,161.1,157.7,103.8,70.6,106,84.3,87.7,60.8,42.3,52,55.6,42.9,56.7,52.4,52.7,56.6,50,80.8,90.2,88.3,58.2,39.6,59.4,47.2,49.1,34.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q86YQ8","Copine-8 [OS=Homo sapiens]",4,2,4,1,564,63.1,5.96,11.27,"other biological processes","plasma membrane;other membranes","other molecular function","CPNE8","ENSG00000139117","","CDC42 GTPase cycle; RHOD GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle","",0.59,0.691,0.711,0.591,0.629,84.1,98.5,101.3,142.4,84.2,89.5,72.6,62.3,66.8,74.5,78.3,85.1,84.3,80.5,72.7,113.2,113,458.8,64.1,66.9,93.8,59.3,71.2,82.6,67.4,57.9,62.1,69.2,72.7,79,78.3,74.8,67.6,105.2,105,426.2,59.5,62.2,87.1,55.1,66.1,76.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8N9N8","probable RNA-binding protein EIF1AD [OS=Homo sapiens]",38,5,8,5,165,19,5.21,30.58,"protein metabolism;other metabolic processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity","EIF1AD","ENSG00000175376","","","",0.591,0.732,0.666,0.707,0.64,81.8,101.3,92.2,138.4,97.8,88.6,75,68.7,88.1,98.4,92.9,75,84.6,91.6,77,126.9,111,299.4,96,85.2,89.7,83,76.1,81.2,377,345.5,442.8,494.9,467.1,376.9,425.1,460.6,386.9,638.1,558.1,1505.1,482.6,428.3,450.9,417,382.6,408.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q56NI9","N-acetyltransferase ESCO2 [OS=Homo sapiens]",5,2,3,2,601,68.3,9.39,9.41,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","ER/Golgi;nucleus;other cell component","other molecular function","ESCO2","ENSG00000171320","","Establishment of Sister Chromatid Cohesion","Cohesin complex - Cornelia de Lange syndrome",0.591,0.659,0.676,0.605,0.621,85.4,95.2,97.8,144.5,87.5,89.7,82.2,87,84.1,93.8,94.7,92.1,96.3,100,93,136.6,159.3,142.3,91.9,84.8,86.2,85.5,88.3,101.9,98.9,104.7,101.1,112.8,113.9,110.7,115.8,120.2,111.9,164.2,191.5,171.2,110.5,101.9,103.6,102.9,106.2,122.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q3T8J9-1","GON-4-like protein [OS=Homo sapiens]",1,1,1,1,2241,248.5,5.01,3.04,"developmental processes;other biological processes","nucleus","other molecular function","GON4L","ENSG00000116580","","","",0.591,0.548,0.61,0.623,0.573,89.9,83.4,92.8,152.1,94.7,87.2,66.2,90,120.6,83.4,78.9,99.8,98.5,92.8,89.3,152.2,184.1,114.9,94.8,73.9,96.7,67.3,87.2,109.6,13.9,18.9,25.4,17.6,16.6,21,20.7,19.5,18.8,32,38.7,24.2,19.9,15.5,20.4,14.2,18.4,23.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O95551-1","Tyrosyl-DNA phosphodiesterase 2 [OS=Homo sapiens]",21,5,10,5,362,40.9,5.1,40.15,"DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TDP2","ENSG00000111802","","Nonhomologous End-Joining (NHEJ)","Oxidative damage response",0.591,0.658,0.58,0.646,0.565,87.8,97.7,86.1,148.5,95.9,83.9,81.6,89.4,84.3,89.3,93.7,119.6,106.9,82.6,75.4,137.3,142.5,187.2,92.1,92.9,83.1,84.1,77.2,80.6,750.1,822.1,774.9,821.4,861.9,1099.7,982.5,759.6,693.6,1262.3,1310.1,1721.3,846.5,854.3,764.4,773.4,709.6,740.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8TEA1","Putative methyltransferase NSUN6 [OS=Homo sapiens]",2,1,1,1,469,51.7,7.96,2.54,"RNA metabolism OR transcription;other metabolic processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","NSUN6","ENSG00000241058","","tRNA modification in the nucleus and cytosol","",0.592,0.706,0.631,0.836,0.633,80.8,96.3,86.1,136.4,114.1,86.3,72,75.1,112.3,83.6,124.3,89.5,80,63.5,85.1,126.8,90.4,235,113.1,86.6,106.1,80.3,75.3,101.1,15.1,15.7,23.5,17.5,26,18.8,16.8,13.3,17.8,26.6,18.9,49.2,23.7,18.2,22.2,16.8,15.8,21.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y6K1","DNA (cytosine-5)-methyltransferase 3A [OS=Homo sapiens]",2,2,3,2,912,101.8,6.57,4.65,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DNMT3A","ENSG00000119772","Cysteine and methionine metabolism; Metabolic pathways; MicroRNAs in cancer","PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; RMTs methylate histone arginines; SUMOylation of DNA methylation proteins","One-carbon metabolism; Trans-sulfuration and one-carbon metabolism; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; One-carbon metabolism and related pathways; MTHFR deficiency",0.593,0.608,0.663,0.645,0.636,85.9,88,95.9,144.7,93.4,92,36.4,34.3,40.4,36.2,83.5,37.3,40.8,38.8,40.7,61.3,39.6,1090,35.9,41.4,39.6,24.1,39,40.8,85.6,80.8,95.1,85.2,196.3,87.8,95.9,91.2,95.7,144.3,93.2,2564.1,84.5,97.3,93.1,56.7,91.8,95.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NZ63","Telomere length and silencing protein 1 homolog [OS=Homo sapiens]",15,4,5,4,289,33.7,6.74,15.41,"other biological processes","cytosol;nucleus","","C9orf78","ENSG00000136819","","","",0.595,0.765,0.886,0.893,0.631,74.9,96.3,111.4,125.8,112.4,79.3,72.8,68.8,113.1,93.6,97.2,90.7,108.3,117.6,102.7,142.3,97.8,122.2,110.6,82.6,109.2,123.3,77.1,69.9,487,460.5,756.8,626.2,650.8,607,724.9,787.1,687.6,952.6,654.5,818.1,740.1,552.5,730.9,825.5,516.1,468.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9GZR1","sentrin-specific protease 6 [OS=Homo sapiens]",5,4,4,4,1112,126.1,6.73,9.14,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","SENP6","ENSG00000112701","","","",0.595,0.725,0.743,0.725,0.707,79.5,96.8,99.1,133.5,96.8,94.3,70.4,73.5,94.1,89.4,95.9,84.7,96.3,91.6,82.8,112.2,123.4,255,89.5,87.4,94.9,88.4,87.2,83.2,206.5,215.6,276.1,262.5,281.6,248.7,282.5,268.9,243.1,329.4,362.2,748.4,262.6,256.6,278.5,259.4,255.9,244.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P30825","High affinity cationic amino acid transporter 1 [OS=Homo sapiens]",2,1,4,1,629,67.6,5.43,10.48,"transport;other biological processes","plasma membrane;other membranes;other cell component","transporter activity","SLC7A1","ENSG00000139514","MicroRNAs in cancer","Amino acid transport across the plasma membrane","VEGFA-VEGFR2 signaling pathway",0.597,0.573,0.64,0.739,0.689,84.5,81.2,90.6,141.6,104.6,97.5,80.4,85.4,85.4,83,79.6,82,97.3,88.7,91.5,143,159.2,124.7,107,105.6,94,91.1,98.5,103.8,309.8,329.1,329.3,319.8,306.8,316,374.9,341.9,352.5,551.1,613.6,480.6,412.3,407.1,362.2,351,379.5,399.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q00534","Cyclin-dependent kinase 6 [OS=Homo sapiens]",33,9,22,8,326,36.9,6.46,69.7,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","CDK6","ENSG00000105810","Cell cycle; p53 signaling pathway; PI3K-Akt signaling pathway; Cellular senescence; Cushing syndrome; Hepatitis C; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Pathways in cancer; Viral carcinogenesis; MicroRNAs in cancer; Pancreatic cancer; Glioma; Melanoma; Chronic myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma","Oxidative Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Oncogene Induced Senescence; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6; Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6; Regulation of RUNX1 Expression and Activity","miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Cell cycle; Metastatic brain tumor; Glioblastoma signaling pathways; Retinoblastoma gene in cancer; Wnt signaling pathway; PI3K-Akt signaling pathway; Tumor suppressor activity of SMARCB1; Non-small cell lung cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; G1 to S cell cycle control; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Influence of laminopathies on Wnt signaling; DNA damage response",0.597,0.633,0.656,0.698,0.706,83.6,88.5,91.7,139.9,97.6,98.7,83.9,81.8,83.6,88.6,91.4,82.6,92.6,91.8,90.8,140,150.2,129.5,97.7,100.9,92,98.8,98.4,105.3,1677.4,1635,1672,1771.8,1826.5,1651.3,1852,1835.8,1814.8,2799.1,3001.6,2588.5,1952.8,2016.7,1838.7,1975.2,1968,2104.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O95817","BAG family molecular chaperone regulator 3 [OS=Homo sapiens]",4,2,3,2,575,61.6,6.95,7.24,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","BAG3","ENSG00000151929","","Regulation of HSF1-mediated heat shock response","",0.597,0.918,1.199,1.115,0.657,65.3,100.4,131.1,109.3,121.9,71.9,57.9,60.7,120.4,102.6,93.3,79.8,124.3,121.9,111.8,101.6,61.5,179.7,113.3,96.3,128.1,116.1,63.8,66.8,81.2,85.2,169,144,130.9,112,174.4,171,156.9,142.6,86.3,252.2,158.9,135.1,179.7,163,89.5,93.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q16649","Nuclear factor interleukin-3-regulated protein [OS=Homo sapiens]",8,3,3,3,462,51.4,7.18,6.79,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NFIL3","ENSG00000165030","","Circadian Clock","Development and heterogeneity of the ILC family; IL-4 signaling pathway",0.597,0.577,0.583,0.604,0.567,91.2,88.2,89,152.7,92.3,86.5,94.3,83,91.2,88.1,93.4,85.6,88.6,89.4,89,152.6,158.9,147.1,84.3,97,92.2,86.5,92.8,86.2,167.8,147.6,162.2,156.8,166.1,152.4,157.6,159.1,158.3,271.5,282.8,261.7,149.9,172.6,164.1,153.9,165,153.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P52789","Hexokinase-2 [OS=Homo sapiens]",20,14,18,14,917,102.3,6.05,49.54,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cell component","kinase activity;other molecular function","HK2","ENSG00000159399","Glycolysis / Gluconeogenesis; Fructose and mannose metabolism; Galactose metabolism; Starch and sucrose metabolism; Amino sugar and nucleotide sugar metabolism; Neomycin, kanamycin and gentamicin biosynthesis; Metabolic pathways; Carbon metabolism; Biosynthesis of nucleotide sugars; HIF-1 signaling pathway; Insulin signaling pathway; Type II diabetes mellitus; Carbohydrate digestion and absorption; Shigellosis; Central carbon metabolism in cancer","Glycolysis","Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis",0.598,0.646,0.7,0.697,0.752,81.7,88.2,95.6,136.6,95.2,102.7,84.2,84,84,94.3,90.7,89,98.2,100.9,98.1,155.7,140.4,79,97.3,97.9,98.4,105.6,95,107.3,1684.7,1679.5,1679,1885.9,1813.2,1779.5,1964.7,2017,1962.1,3112.7,2808,1579,1946.4,1957,1968.1,2112.3,1899.8,2145.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8N1G1","RNA exonuclease 1 homolog [OS=Homo sapiens]",1,1,1,1,1221,131.4,8.95,2.03,"other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","REXO1","ENSG00000079313","Ribosome biogenesis in eukaryotes","","",0.598,0.708,0.607,0.672,0.584,86.1,101.9,87.4,143.9,96.7,84,86.7,64,101.4,73,102.6,119.2,79.4,121.8,88,144.9,107.1,155.5,77.2,97.4,104.1,112.2,80.8,84.7,19,14,22.2,16,22.4,26,17.4,26.6,19.2,31.7,23.4,34,16.9,21.3,22.8,24.5,17.7,18.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96AK3","DNA dC->dU-editing enzyme APOBEC-3D [OS=Homo sapiens]",13,4,15,1,386,46.6,8.4,51.43,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","APOBEC3D","ENSG00000243811","","","",0.599,0.469,0.604,0.675,0.517,93,72.8,93.8,155.3,104.8,80.3,122.4,82.1,76.9,67.6,55.7,64.3,119,65.2,82.8,137.1,112.3,260.9,82.1,111.8,92.6,65.7,70.8,130.9,32.8,22,20.6,18.1,14.9,17.2,31.9,17.5,22.2,36.7,30.1,69.9,22,29.9,24.8,17.6,19,35,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O43493-4","Isoform 4 of Trans-Golgi network integral membrane protein 2 [OS=Homo sapiens]",44,15,33,1,379,39.5,5.59,87.4,"","","","TGOLN2","","","","",0.599,0.643,0.521,0.67,0.552,90.2,96.8,78.5,150.5,100.9,83,90.4,87.6,89.5,105.7,96,91.1,85.1,77.8,75.1,149.3,143.5,157.7,103.6,100,90,93.5,81.9,82.3,448.6,435,444.1,524.5,476.7,452.1,422.7,386.2,372.6,741,712.3,783,514.2,496.7,446.6,463.9,406.7,408.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NYP3-1","Protein downstream neighbor of son [OS=Homo sapiens]",2,1,1,1,566,62.7,8.66,3.9,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction","nucleus;other cell component","","DONSON","ENSG00000159147","","","",0.6,0.666,0.645,0.783,0.844,79.3,88.1,85.3,132.2,103.6,111.6,74.6,76.5,83.1,93.6,84.9,77.6,82.2,101.6,81.9,107.5,127.4,201.8,92,99.8,103,92.7,107.6,112,73,74.8,81.2,91.6,83,75.9,80.4,99.4,80.1,105.1,124.7,197.4,90,97.7,100.8,90.7,105.2,109.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H6R4-1","Nucleolar protein 6 [OS=Homo sapiens]",14,13,27,12,1146,127.5,7.64,60.97,"RNA metabolism OR transcription;other metabolic processes;transport","mitochondrion;nucleus;other cell component","","NOL6","ENSG00000165271","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",0.6,0.637,0.602,0.616,0.587,89.1,94.6,89.4,148.4,91.5,87.1,90.2,87.7,86.7,93.1,94.7,93.1,89.3,87.7,88,146.1,144.1,170.6,89.3,90.1,91.3,85.7,83.9,88.4,2883.9,2803.2,2772.9,2975.7,3028.4,2976.1,2855.4,2804.3,2812.1,4671.3,4605.9,5454.2,2855.9,2879.3,2918.4,2740,2683.6,2827.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q71RG4-1","Transmembrane and ubiquitin-like domain-containing protein 2 [OS=Homo sapiens]",2,1,2,1,321,33.8,5.03,2.22,"protein metabolism;other metabolic processes;stress response","other membranes","","TMUB2","ENSG00000168591","","","",0.6,0.7,0.617,0.637,0.575,87.2,101.7,89.6,145.3,92.6,83.6,86.9,85.9,89.2,101.9,81.2,101.3,89.3,84.6,90.7,135.5,144.8,181.3,92.3,109,83.3,83.2,85.2,74.4,98,96.9,100.6,115,91.5,114.3,100.7,95.4,102.3,152.8,163.3,204.5,104.1,122.9,94,93.9,96.1,83.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q5JVS0","Intracellular hyaluronan-binding protein 4 [OS=Homo sapiens]",2,1,1,1,413,45.8,7.46,2.17,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","HABP4","ENSG00000130956","","Platelet degranulation","",0.601,0.641,0.654,0.636,0.612,87,92.8,94.7,144.8,92.1,88.6,85,69.3,116.1,90.7,92.1,87.2,92.1,96.9,92.6,141.5,122.7,179.7,92.1,89.8,90,94.1,81.4,86.6,69.6,56.7,95,74.3,75.4,71.4,75.4,79.3,75.8,115.8,100.4,147.1,75.4,73.5,73.6,77,66.7,70.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P38398","Breast cancer type 1 susceptibility protein [OS=Homo sapiens]",2,3,4,3,1863,207.6,5.41,11.57,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","BRCA1","ENSG00000012048","Platinum drug resistance; Homologous recombination; Fanconi anemia pathway; Ubiquitin mediated proteolysis; PI3K-Akt signaling pathway; MicroRNAs in cancer; Breast cancer","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; G2/M DNA damage checkpoint; Metalloprotease DUBs; Processing of DNA double-strand break ends; TP53 Regulates Transcription of DNA Repair Genes; Meiotic synapsis; Resolution of D-loop Structures through Holliday Junction Intermediates; SUMOylation of DNA damage response and repair proteins; Transcriptional Regulation by E2F6; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Meiotic recombination; HDR through Single Strand Annealing (SSA); Nonhomologous End-Joining (NHEJ); Defective DNA double strand break response due to BRCA1 loss of function; Defective DNA double strand break response due to BARD1 loss of function","Androgen receptor signaling pathway; miRNA regulation of DNA damage response; Glioblastoma signaling pathways; Hepatitis C and hepatocellular carcinoma; Pathways affected in adenoid cystic carcinoma; PI3K-Akt signaling pathway; Breast cancer pathway; DNA repair pathways, full network; Malignant pleural mesothelioma; Nucleotide excision repair in xeroderma pigmentosum ; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; DNA damage response",0.601,0.59,0.56,0.563,0.58,92.6,90.9,86.3,154.1,86.7,89.4,97.7,92.1,93.2,84.1,91.5,91.5,84.1,86.9,90.7,160.1,155.1,133.1,83.8,89.9,87.3,85.2,103.7,90,208.3,196.5,198.7,179.4,195.1,195.1,179.2,185.2,193.5,341.5,330.7,283.7,178.6,191.7,186.1,181.7,221.1,191.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P20810-5","Isoform 5 of Calpastatin [OS=Homo sapiens]",67,41,194,1,756,81.1,5.2,480.7,"","","","CAST","","","","",0.601,0.606,0.674,0.652,0.617,86.9,87.6,97.5,144.6,94.2,89.3,83.7,109,83,113,84.3,83.2,112.4,79.6,93.9,104.3,139.3,192.2,90.7,97.6,82.1,87.4,78.3,86,94.9,123.6,94.1,128.1,95.6,94.3,127.4,90.2,106.4,118.2,157.9,217.9,102.9,110.7,93,99.1,88.8,97.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y4C8","Probable RNA-binding protein 19 [OS=Homo sapiens]",6,5,6,5,960,107.3,6.54,18.91,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","RBM19","ENSG00000122965","","","",0.601,0.637,0.589,0.579,0.576,90.6,95.9,88.7,150.7,87.3,86.7,89.4,87.7,94.4,99.1,91.7,94.6,85.7,91.2,87.5,134,148.6,177.2,85.1,86.1,93.6,85.6,86,82.6,286.5,281.3,302.5,317.7,293.8,303.4,274.7,292.2,280.6,429.6,476.6,568.1,272.8,276.1,300.1,274.3,275.6,264.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NQ25-1","SLAM family member 7 [OS=Homo sapiens]",21,6,18,3,335,37.4,6.43,61.51,"cell adhesion;stress response;other biological processes","plasma membrane;other membranes","other molecular function","SLAMF7","ENSG00000026751","","Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell","",0.602,0.715,0.658,0.677,0.644,84.1,99.9,91.9,139.7,94.5,89.9,80.6,88.2,83.8,99.5,91.3,99.9,85.5,91.6,102.6,139.2,153.3,125.6,93.6,97.3,94.2,89.2,94.9,89.6,1414,1546.7,1469.1,1744.7,1600.2,1751.7,1498.2,1606,1799.6,2440.3,2687.9,2202.6,1641.6,1706.2,1651.1,1564,1664.2,1570.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q14671-3","Isoform 3 of Pumilio homolog 1 [OS=Homo sapiens]",12,12,15,8,1188,126.6,6.84,37.44,"","","","PUM1","","","","",0.602,0.652,0.592,0.578,0.546,91,98.5,89.5,151.1,87.3,82.5,95.8,87.8,89.6,95.4,108.9,97,93.4,88.1,86,148.7,141.8,161.3,84.9,87.6,86,81.2,79.8,86.9,1158.9,1062.6,1084.2,1153.9,1317.2,1173.2,1130,1066.3,1040.1,1799.8,1716.3,1951.3,1027,1060.3,1040.3,982.2,965.6,1051.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q68CQ4","Digestive organ expansion factor homolog [OS=Homo sapiens]",17,10,17,10,756,87,5.88,47.14,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","UTP25","ENSG00000117597","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",0.603,0.614,0.596,0.606,0.614,89.6,91.4,88.7,148.8,90.1,91.4,90.1,89.4,87,91.2,89.9,95.1,88.5,88.1,90.8,148.4,140.7,160,87.5,90.1,89.9,91.2,91.7,90.3,1270.2,1260.7,1226.8,1285.2,1267.2,1341,1247.4,1242.2,1280,2091.9,1982.7,2255.5,1233,1269.5,1267.2,1285.5,1293,1273,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q14814-1","Myocyte-specific enhancer factor 2D [OS=Homo sapiens]",11,3,3,3,521,55.9,7.88,7.21,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MEF2D","ENSG00000116604","cGMP-PKG signaling pathway; Apelin signaling pathway; Parathyroid hormone synthesis, secretion and action","Myogenesis; NGF-stimulated transcription; Heme signaling; Circadian Clock; Transcriptional activation of mitochondrial biogenesis","Energy metabolism; SRF and miRs in smooth muscle differentiation and proliferation; Cell differentiation - expanded index; Cell differentiation - index; B cell receptor signaling pathway; Adipogenesis; p38 MAPK signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; EGF/EGFR signaling pathway; Gastrin signaling pathway; Modulators of TCR signaling and T cell activation; Malignant pleural mesothelioma",0.603,0.595,0.583,0.503,0.516,95.2,93.9,92,157.9,79.4,81.4,88.5,96.6,93.9,83.8,92.7,116.6,100.1,86.7,90.8,135.1,155.8,178.2,78.4,67.5,84.8,80.3,91,79.3,284.6,310.6,302,269.2,297.9,374.8,321.9,278.6,291.9,434.1,500.8,572.8,251.9,216.9,272.7,258.2,292.6,254.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H2G9-1","Golgin-45 [OS=Homo sapiens]",3,1,1,1,400,44.9,8.54,2.25,"cell organization and biogenesis;transport","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","BLZF1","ENSG00000117475","","Golgi Cisternae Pericentriolar Stack Reorganization","",0.603,0.565,0.563,0.541,0.617,93.1,87.2,86.9,154.3,83.5,95.2,95.8,101,83.6,90.2,87.4,89.7,89.4,88.7,97.2,158.7,166.1,94.6,92.4,85.8,84.3,97.9,100.1,97.1,62,65.4,54.1,58.4,56.6,58,57.8,57.4,62.9,102.7,107.5,61.2,59.8,55.6,54.6,63.4,64.8,62.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UK73","Protein fem-1 homolog B [OS=Homo sapiens]",2,1,2,1,627,70.2,6.61,3.81,"protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","FEM1B","ENSG00000169018","","Neddylation","",0.603,0.733,0.483,0.511,0.623,91.6,111.3,73.3,151.8,77.6,94.5,93.5,88.5,94.2,108.6,113.6,118.9,72.6,81.5,74.9,226,154.9,73.3,63.2,79.2,79.4,110.2,96.5,70.9,22.5,21.3,22.7,26.1,27.3,28.6,17.5,19.6,18,54.4,37.3,17.6,15.2,19,19.1,26.5,23.2,17.1,"High","High","High","High","High","High","High","High","High","High","High","Not Found","High","High","High","High","High","High"]
["Q9BZX2-1","Uridine-cytidine kinase 2 [OS=Homo sapiens]",23,6,11,5,261,29.3,6.7,29.17,"other metabolic processes","cytosol;other cell component","kinase activity;other molecular function","UCK2","ENSANAG00000031914; ENSCATG00000024308; ENSCCAG00000017279; ENSCJAG00000004523; ENSCSAG00000010772; ENSG00000143179; ENSGGOG00000038402; ENSMFAG00000032681; ENSMMUG00000053859; ENSMNEG00000040312; ENSPANG00000016507; ENSPTRG00000001619","Pyrimidine metabolism; Drug metabolism; Metabolic pathways","Pyrimidine salvage","Fluoropyrimidine activity; Pyrimidine metabolism",0.604,0.624,0.609,0.617,0.61,89.2,92.1,90,147.6,91.1,90.1,92.8,86.1,89.4,93.4,91.6,92.2,87.1,90.8,90.1,147.9,137.1,155,92.9,90.1,91.2,90.2,85,97,855.1,793.4,823.3,860.7,844.2,849.7,802.6,836.8,830.3,1362.7,1262.8,1428.5,855.8,829.8,840.7,831.4,783,893.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q99848","Probable rRNA-processing protein EBP2 [OS=Homo sapiens]",21,7,25,7,306,34.8,10.1,75.65,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","EBNA1BP2","ENSG00000117395","","Major pathway of rRNA processing in the nucleolus and cytosol","",0.604,0.595,0.567,0.55,0.53,94.3,92.8,88.4,156,85.8,82.7,90.3,93.5,94.9,92,97.4,91.4,88,86,87.7,152.2,154.7,169.8,85.1,87.1,84.9,80.7,82,82.4,2707.8,2802.1,2846.1,2759.5,2918.9,2740.4,2639.5,2577.7,2628.5,4561.9,4636.9,5092.1,2550.2,2610.9,2546.9,2419.4,2457.8,2471.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P0DJ07","Protein PET100 homolog, mitochondrial [OS=Homo sapiens]",14,2,2,2,73,9.1,6.77,5.93,"cell organization and biogenesis","other membranes;mitochondrion","other molecular function","PET100","ENSG00000229833","","","Mitochondrial complex IV assembly",0.605,0.52,0.493,0.459,0.564,99.6,85.7,81.3,164.8,75.6,92.9,96.2,115.5,79.4,82.8,81.5,89.5,85.7,78.5,71.7,159.1,196.9,134.7,80,73,67.9,81.2,136.8,89.7,96.2,115.5,79.4,82.8,81.5,89.5,85.8,78.5,71.7,159.1,197,134.7,80,73,67.9,81.2,136.8,89.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q13123","Protein Red [OS=Homo sapiens]",28,13,29,13,557,65.6,6.64,82.68,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","IK","ENSG00000113141","","","",0.605,0.626,0.615,0.562,0.568,91.3,94.5,92.8,150.9,84.8,85.7,91.4,87.8,105.4,108.8,94.6,94.6,92.9,96.1,84.4,151.1,163.1,120.3,88.4,84.9,84.4,89.3,85.9,76.6,2555.4,2455.5,2947.6,3041.8,2644.1,2645.4,2597.5,2688.1,2359.7,4225.1,4559.8,3362.4,2472.7,2374.5,2359.2,2497.6,2400.6,2142,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O60828","Polyglutamine-binding protein 1 [OS=Homo sapiens]",19,4,9,4,265,30.5,6.33,27.86,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","PQBP1","ENSG00000102103","Spliceosome","mRNA Splicing - Major Pathway","",0.605,0.767,0.756,0.716,0.642,81,102.6,101.1,133.7,95.7,85.9,78.4,76.3,97.9,118.9,99.3,87,94.1,108.1,97.9,128.5,129.5,137.4,92.7,91,102.4,95.7,81.6,83.2,571.3,556.4,713.8,866.8,724.1,634,686.2,788.2,713.7,937,943.8,1001.3,675.4,663.1,746.4,697.9,594.6,606.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P62633-1","Cellular nucleic acid-binding protein [OS=Homo sapiens]",50,9,54,1,177,19.5,7.71,136.79,"DNA metabolism;other metabolic processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","Cnbp; CNBP; LOC101344172; LOC111159043; LOC113917796","ENSAMEG00000015334; ENSBIXG00000009042; ENSBMUG00000014129; ENSCAFG00000004320; ENSCANG00000042967; ENSCATG00000020089; ENSCCAG00000034056; ENSCGRG00001000923; ENSCJAG00000017430; ENSCPOG00000032294; ENSCSAG00000008817; ENSDLEG00000010302; ENSECAG00000009512; ENSFCAG00000042197; ENSG00000169714; ENSHGLG00000002069; ENSLAFG00000002502; ENSLCNG00005005148; ENSMFAG00000030262; ENSMLEG00000041892; ENSMMUG00000058753; ENSMNEG00000028473; ENSMPUG00000017315; ENSNLEG00000035879; ENSOCUG00000008696; ENSPANG00000007815; ENSPCTG00005021559; ENSPPYG00000013423; ENSPTRG00000015369; ENSRBIG00000030361; ENSRNOG00000010239; ENSRROG00000045469; ENSSBOG00000023735; ENSSSCG00070013675; ENSSTOG00000000173; ENSTSYG00000004344; ENSTTRG00000015266; ENSVVUG00000018264","","","",0.605,0.606,0.62,0.657,0.612,88.6,88.7,90.8,146.3,96.1,89.5,97.7,89,86.9,91.1,89.1,88.1,99.4,91.1,86.4,153.8,146.9,116.6,96.5,102.7,93.8,89.9,86.8,94.2,5257.4,4785.8,4675.1,4899.4,4790.8,4738.3,5345.8,4902.5,4646.5,8275.2,7904.2,6269.5,5191.8,5525.3,5043,4833.7,4671.2,5066.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96C55","Zinc finger protein 524 [OS=Homo sapiens]",4,1,1,1,264,28.7,8.75,2.77,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF524","ENSG00000171443","","","",0.606,0.715,0.945,0.978,0.733,73.1,86.2,114,120.5,117.9,88.3,62.5,72.4,97.5,85.4,96.6,64.4,112.9,118.8,95.3,119.5,94.8,180.9,129,91,116.9,105.9,87.5,68.7,29.4,34,45.7,40.1,45.3,30.2,53,55.7,44.7,56.1,44.5,84.9,60.5,42.7,54.9,49.7,41.1,32.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96QE3-1","ATPase family AAA domain-containing protein 5 [OS=Homo sapiens]",4,4,4,4,1844,207.4,9.19,6.82,"stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ATAD5","ENSG00000176208","","","",0.606,0.598,0.582,0.594,0.612,91.1,89.9,87.5,150.3,89.3,91.9,84.3,91.7,99.7,90.5,94.1,82.3,84.6,88.1,88.9,139.6,154.8,151.3,86.2,100.3,89.9,92.6,93.6,87.6,157.6,171.4,186.3,169.2,175.8,153.8,158,164.6,166,260.8,289.2,282.7,161,187.5,168,172.9,174.9,163.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y385","ubiquitin-conjugating enzyme e2 j1 [OS=Homo sapiens]",33,9,26,9,318,35.2,6.74,93.82,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","UBE2J1","ENSG00000198833","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum; Parkinson disease; Pathways of neurodegeneration","Antigen processing: Ubiquitination & Proteasome degradation","Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway",0.607,0.614,0.61,0.642,0.636,88.6,89.7,89,146,93.8,92.9,82.3,87.9,87.7,88.8,88.8,88.3,88.1,85.9,88.9,136.6,144.5,185.6,90.1,93.4,92.8,84.8,91.9,93.7,1570.3,1677.7,1673.4,1695.3,1694.8,1686.2,1681.8,1639,1697.1,2608.3,2758.8,3543.6,1719.7,1783.5,1771.3,1619.2,1755.1,1788.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NQZ2","Something about silencing protein 10 [OS=Homo sapiens]",19,7,23,7,479,54.5,5.62,68.25,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","","UTP3","ENSG00000132467","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",0.608,0.569,0.525,0.576,0.542,95.4,89.4,82.5,157.1,90.5,85.1,97.7,98,97.6,91.3,102.5,91.6,91.4,84.4,83,160.8,162.4,101,92.7,96.1,88,88,87.1,86.4,1226.4,1230.1,1225.1,1145.6,1285.9,1149.4,1147,1059.5,1041.5,2018.4,2038.2,1268.1,1163.3,1206.3,1104.2,1104.3,1093,1084.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q7Z3K6-1","Mesoderm induction early response protein 3 [OS=Homo sapiens]",5,2,2,2,550,61.4,4.51,6.44,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","MIER3","ENSG00000155545; ENSGGOG00000015237","","","",0.608,0.767,0.625,0.7,0.665,83.6,105.4,85.9,137.4,96.2,91.5,105.8,81.9,81.9,101.6,124.8,103.3,84.1,95.3,83.8,151.7,134.6,112.1,94.2,70.7,122.6,95.5,89.6,66.6,23.5,18.2,18.2,22.6,27.8,23,18.7,21.2,18.7,33.8,30,25,21,15.7,27.3,21.3,19.9,14.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O00767","acyl-CoA desaturase [OS=Homo sapiens]",13,5,23,5,359,41.5,9,75.05,"other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","SCD","ENSG00000099194","Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; AMPK signaling pathway; Alcoholic liver disease","Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis","Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Adipogenesis; Liver X receptor pathway; Nuclear receptors meta-pathway; Fatty acid biosynthesis; Angiopoietin-like protein 8 regulatory pathway; PPAR signaling pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways",0.609,0.568,0.627,0.692,0.652,88.1,82.1,90.6,144.7,100.1,94.4,86.2,90.4,90.1,91.7,84,71.1,92.5,92.8,95,148.1,182.6,79.3,107.9,102.5,95.2,96.6,93.9,100.1,2904,3043.2,3034.8,3089.4,2830.2,2395.7,3113.5,3124.3,3200.1,4986.8,6148,2671.5,3633.3,3451.1,3204.5,3252,3162.6,3372,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UL58","Zinc finger protein 215 [OS=Homo sapiens]",2,1,1,1,517,60,8.72,2.99,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF215","ENSG00000149054","","Generic Transcription Pathway","",0.609,0.735,0.749,0.692,0.722,81,97.9,99.7,133.1,92.2,96.1,79.4,56.8,84.8,95.9,120.9,93.1,91.7,104.2,97.6,130.4,128.3,169.2,90.3,91.5,70.7,93.8,94.2,107.1,41.9,30,44.8,50.6,63.8,49.1,48.4,55,51.5,68.8,67.7,89.3,47.6,48.3,37.3,49.5,49.7,56.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O15234","Protein CASC3 [OS=Homo sapiens]",17,9,11,9,703,76.2,6.48,19.86,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","CASC3","ENSG00000108349","Nucleocytoplasmic transport; mRNA surveillance pathway","Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","",0.609,0.61,0.617,0.633,0.612,89.5,89.7,90.7,147,93.1,90,92.2,88.5,88.6,83.9,90.3,88.7,89.8,90.1,86.5,145.5,143.7,162.8,89.5,92.1,96.8,93,89.1,88.8,1406.7,1351.1,1351.9,1280.8,1378.5,1354.3,1370.5,1375.7,1320.2,2220.8,2193.9,2484.5,1366.6,1405.8,1478.2,1419,1359.3,1355.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UHA3","Probable ribosome biogenesis protein RLP24 [OS=Homo sapiens]",12,2,5,2,163,19.6,9.98,12.05,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytosol;translational apparatus;nucleus","nucleic acid binding activity;other molecular function","RSL24D1","ENSG00000137876","Ribosome; Coronavirus disease","","",0.609,0.597,0.567,0.625,0.607,91.3,89.4,85,149.8,93.7,90.9,84.7,91.8,93.5,91.1,89.9,83.4,91.7,85.5,81.3,145.3,150.7,169.9,99.9,94.2,80.7,94.1,91.5,80.8,426.6,462.2,471,458.8,452.7,419.8,461.6,430.3,409.4,731.7,758.6,855.4,503.1,474.5,406.4,473.6,460.4,406.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96BD8","Spindle and kinetochore-associated protein 1 [OS=Homo sapiens]",7,1,1,1,255,29.5,7.12,4.68,"cell cycle OR cell proliferation;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity","SKA1","ENSG00000154839; ENSG00000262634","","RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",0.609,0.52,0.408,0.484,0.45,105.3,89.8,70.5,172.8,83.7,77.8,109.8,112.4,104.8,69,93.7,142.5,73.5,67.1,81.5,180.2,194.1,43.4,105.9,78.5,87.3,81.1,100.6,74.6,87.2,89.3,83.2,54.8,74.4,113.2,58.4,53.3,64.7,143.2,154.2,34.5,84.2,62.3,69.3,64.4,79.9,59.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BW85","Coiled-coil domain-containing protein 94 [OS=Homo sapiens]",8,4,10,3,323,37.1,5.92,25.05,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","YJU2","ENSG00000105248","","","",0.61,0.571,0.618,0.593,0.653,90.4,84.6,91.7,148.3,88,96.9,90.4,87.3,103.1,84.6,77.3,100.9,92.7,91.7,86.5,156.6,148.3,121.7,90.7,86.6,88,96.9,115.6,81.1,599.9,578.9,684.3,561.6,512.9,669.6,614.8,608.2,574.1,1039.1,984.1,807.3,601.7,574.3,584,643.1,767.2,537.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9ULL5-1","Proline-rich protein 12 [OS=Homo sapiens]",1,2,2,2,1215,129.9,8,5.67,"","","","PRR12","ENSG00000126464","","","",0.61,0.603,0.568,0.572,0.555,93.6,92.6,87.2,153.6,87.8,85.2,77.1,71.1,80.5,72.1,76.3,77.3,74,71.9,68.4,126.5,126.3,460.7,76.4,64.6,72.3,70.3,70.2,63.8,170.2,156.9,177.7,159,168.3,170.5,163.3,158.5,151,279.1,278.7,1016.2,168.5,142.5,159.6,155.1,154.8,140.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6JBY9","CapZ-interacting protein [OS=Homo sapiens]",32,9,16,9,416,44.5,5.4,54.59,"stress response;other biological processes","cytoskeleton","cytoskeletal activity","RCSD1","ENSG00000198771","","","",0.61,0.831,0.91,0.906,0.653,74.5,101.6,111.2,122.2,110.7,79.8,71.7,66.9,118.3,115.3,97.8,78.1,107,110.3,90.3,130.2,116.4,117.6,106.6,104.6,108.8,106.9,76.8,76.5,1008.8,941.1,1664.4,1621.4,1375.1,1098,1504.7,1551.5,1270.4,1831.7,1637.9,1654.4,1498.9,1471.4,1530.3,1503.8,1079.8,1075.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NXR5","Ankyrin repeat domain-containing protein 10 [OS=Homo sapiens]",5,2,4,2,420,44.7,5.97,11.87,"","","","ANKRD10","ENSG00000088448","","","",0.61,0.679,0.606,0.554,0.568,91.1,101.4,90.5,149.4,82.7,84.9,96.5,94.8,93.7,106.1,98.4,105.5,94.1,99,93.1,155.5,163.5,81.1,90.4,83.6,86.1,88.3,81.5,88.6,406.2,399.1,394.5,446.7,414.2,444.2,396.2,416.8,391.8,654.3,688.2,341.5,380.6,351.9,362.4,371.7,343,372.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H173","nucleotide exchange factor SIL1 [OS=Homo sapiens]",15,6,10,6,461,52.1,5.36,30.11,"transport;other biological processes","ER/Golgi","other molecular function","SIL1","ENSG00000120725","Protein processing in endoplasmic reticulum","","",0.61,0.635,0.66,0.715,0.725,84.2,87.7,91.2,138.1,98.8,100.1,81.6,90,85,90,85.1,88.5,88.4,92,99.3,144.6,139.4,112.3,103.9,96.1,99.7,104.8,98.1,101,423.9,467.8,441.6,467.4,442.2,460,459.5,478,516.2,751.5,724,583.6,539.7,499.4,517.9,544.6,509.9,524.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P51817","camp-dependent protein kinase catalytic subunit prkx [OS=Homo sapiens]",10,2,2,2,358,40.9,6.86,4.26,"cell adhesion;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","nucleus;other cell component","kinase activity;other molecular function","PRKX","ENSG00000183943","","FCGR3A-mediated IL10 synthesis; ADORA2B mediated anti-inflammatory cytokines production; CREB1 phosphorylation through the activation of Adenylate Cyclase; PKA-mediated phosphorylation of CREB","Chemokine signaling pathway",0.61,0.582,0.592,0.661,0.594,90.6,86.4,87.9,148.5,98.2,88.3,83.4,99,74.7,79.5,74,81.8,80.9,80.2,89.1,99.7,136.7,294,90.4,74.2,112.8,81.2,75.4,93.2,24.4,29,21.9,23.3,21.7,24,23.7,23.5,26.1,29.2,40.1,86.2,26.5,21.7,33.1,23.8,22.1,27.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y5A9-1","YTH domain-containing family protein 2 [OS=Homo sapiens]",16,9,24,6,579,62.3,8.79,62.04,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity","YTHDF2","ENSCSAG00000001018; ENSG00000198492; ENSMFAG00000026128; ENSMMUG00000011391; ENSMNEG00000041161; ENSNLEG00000009856; ENSPTRG00000000439; ENSRBIG00000043898; ENSRROG00000038863","","","",0.611,0.681,0.608,0.588,0.57,90.3,100.7,89.9,147.9,86.9,84.4,92.4,94.6,91,100.3,109.5,103,90,92,93.5,158.5,151.3,90.8,88.7,89.7,88.9,86.3,85.1,94.2,1106,1132.1,1089.3,1200.7,1310.9,1233.3,1077.9,1101.4,1118.6,1897.1,1811.7,1087.1,1062,1073.7,1064.4,1033.3,1019.1,1128,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NVM6","DnaJ homolog subfamily C member 17 [OS=Homo sapiens]",2,1,1,1,304,34.7,8.53,2.12,"transport;other biological processes","nucleus;other cell component","nucleic acid binding activity","DNAJC17","ENSG00000104129","","","",0.611,0.463,0.553,0.531,0.478,100.9,76.4,91.3,165,87.6,78.8,92,108.7,93.5,70.8,68.1,97.6,84.6,75.8,94.4,132.8,153,215.6,81.7,69.8,81.2,73.1,136,71.2,82.5,97.5,83.9,63.5,61.1,87.5,75.9,68,84.7,119.1,137.2,193.4,73.3,62.6,72.8,65.5,121.9,63.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O15014","zinc finger protein 609 [OS=Homo sapiens]",1,1,1,1,1411,151.1,8.03,2.25,"developmental processes;other biological processes","nucleus","other molecular function","ZNF609","ENSG00000180357","","","",0.612,0.592,0.641,0.599,0.58,91.3,88.2,95.6,149.1,89.4,86.4,98.2,82.6,92.3,98,89.2,83.9,90.8,98.2,96.7,155.2,140.9,150.8,93.5,82.9,90.4,78.2,87.4,90.9,120.9,101.7,113.6,120.6,109.8,103.3,111.7,120.8,119,191,173.3,185.5,115.1,102,111.2,96.2,107.6,111.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H501","ESF1 homolog [OS=Homo sapiens]",21,16,23,16,851,98.7,5.11,60.09,"RNA metabolism OR transcription;other metabolic processes","nucleus","","ESF1","ENSG00000089048","","","",0.613,0.623,0.601,0.597,0.59,91.4,92.8,89.6,149.1,89.1,88,91.4,92.7,91.4,93.1,92.9,90.1,89.6,91.1,88.2,149.1,162.7,136.2,89.4,88,89.1,89.5,88,87.6,1844.8,1870.9,1845.1,1879.4,1874.8,1818.4,1809.7,1838.7,1781.4,3011.1,3285.8,2749.5,1804.4,1776.6,1798.5,1807.5,1776.1,1769.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BVC5","Ashwin [OS=Homo sapiens]",7,2,2,2,232,25.8,9.74,5.08,"developmental processes","nucleus;other cell component","","C2orf49","ENSG00000135974","","tRNA processing in the nucleus","",0.613,0.63,0.591,0.587,0.535,93,95.6,89.6,151.7,89.1,81.1,97.2,90.1,92.1,100.4,91.8,94.7,88.8,90.9,77.2,150.2,128.7,192.6,92.4,88.2,78.5,80.3,87.8,78.1,227.7,210.9,215.7,235.1,215.1,221.7,208,212.8,180.9,351.9,301.4,451.1,216.3,206.6,183.8,188.1,205.6,182.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UIF7-1","adenine DNA glycosylase [OS=Homo sapiens]",1,1,1,1,546,60,8.69,1.63,"DNA metabolism;other metabolic processes;stress response","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","MUTYH","ENSG00000132781","Base excision repair","","Base excision repair; DNA repair pathways, full network",0.613,0.591,0.552,0.582,0.527,95.2,91.8,85.7,155.2,90.3,81.8,85.6,93.4,97.3,99.2,90.1,84.7,92.8,82.8,84.2,151.4,152.4,154,84.4,106.6,88.7,97.6,74.6,80.3,62.9,68.7,71.5,72.9,66.2,62.3,68.2,60.9,61.9,111.3,112,113.2,62.1,78.4,65.2,71.7,54.8,59,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8N2K1-1","Ubiquitin-conjugating enzyme E2 J2 [OS=Homo sapiens]",5,1,1,1,259,28.9,8.4,4.48,"protein metabolism;other metabolic processes;stress response","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","UBE2J2","ENSG00000160087","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum; Parkinson disease; Pathways of neurodegeneration","Antigen processing: Ubiquitination & Proteasome degradation; E3 ubiquitin ligases ubiquitinate target proteins","Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway",0.613,0.704,0.585,0.604,0.572,90.2,103.6,86,147.1,88.9,84.2,96.5,87.4,85.7,91.2,113.4,100.2,76.5,96,83.3,134.8,142.4,182.2,92.5,86,85.5,85,79.9,81.5,92,83.3,81.7,87,108.1,95.6,73,91.6,79.4,128.6,135.8,173.8,88.3,82,81.5,81,76.2,77.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8NC42","E3 ubiquitin-protein ligase RNF149 [OS=Homo sapiens]",4,1,1,1,400,43.1,6.54,4.35,"protein metabolism;other metabolic processes;other biological processes","other membranes;other cell component","other molecular function","RNF149","ENSG00000163162","","","",0.613,0.769,0.559,0.639,0.547,89.2,111.7,81.3,145.4,92.9,79.5,84.6,84.3,79.8,104.4,114.9,105.7,86.8,74.3,76.9,137.5,123.2,224.8,105.6,75.7,87.8,69.3,89.1,75.2,30.7,30.6,29,37.9,41.7,38.4,31.5,27,27.9,50,44.7,81.7,38.4,27.5,31.9,25.2,32.4,27.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96ES7","SAGA-associated factor 29 [OS=Homo sapiens]",4,1,1,1,293,33.2,8.1,3.72,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","SGF29","ENSG00000176476","","HATs acetylate histones","",0.614,0.565,0.602,0.693,0.631,89.7,82.6,87.9,146.2,101.3,92.3,87.8,107.7,87,80.8,80.5,107.1,94,74.3,86,126.4,143,196.1,99,66.8,107.2,90.5,90.2,75.7,40.8,50,40.4,37.5,37.4,49.7,43.6,34.5,39.9,58.7,66.4,91,46,31,49.8,42,41.9,35.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BWQ6","protein YIPF2 [OS=Homo sapiens]",10,1,1,1,316,35.1,5.73,4.79,"transport","other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","YIPF2","ENSG00000130733","","","",0.614,0.416,0.514,0.504,0.451,105.3,71.4,88.2,171.4,86.3,77.4,106.3,108.8,63.3,91.4,58.7,72,137.2,89,67.6,173.1,173.3,120.6,86.7,138.1,87.2,78.1,57.1,91.5,23.2,23.7,13.8,19.9,12.8,15.7,29.9,19.4,14.7,37.7,37.8,26.3,18.9,30.1,19,17,12.4,19.9,"High","High","High","High","High","High","High","High","High","High","High","Not Found","High","High","High","High","High","High"]
["P60520","Gamma-aminobutyric acid receptor-associated protein-like 2 [OS=Homo sapiens]",35,5,6,5,117,13.7,8.1,15.85,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","GABARAPL2","ENSG00000034713","FoxO signaling pathway; Autophagy; Mitophagy; Autophagy; NOD-like receptor signaling pathway; GABAergic synapse","TBC/RABGAPs; Macroautophagy","Network map of SARS-CoV-2 signaling pathway; Senescence and autophagy in cancer",0.614,0.602,0.61,0.658,0.669,88.8,86.9,88.2,144.4,95,96.7,85.4,81.2,84.2,82.5,80.7,86.2,83.2,83.7,84,134.8,137.1,234,91.4,90.2,87,90.8,92,91.8,716.3,681.3,706.6,691.9,676.7,723.6,697.8,702,704.5,1131.2,1150,1962.8,766.9,756.5,729.6,762,771.5,769.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q7Z333","Probable helicase senataxin [OS=Homo sapiens]",2,3,6,2,2677,302.7,7.17,12.82,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;nucleus;other cell component","nucleic acid binding activity;other molecular function","SETX","ENSG00000107290","Amyotrophic lateral sclerosis","","Interactome of polycomb repressive complex 2 (PRC2)",0.615,0.697,0.609,0.604,0.638,88.6,100.4,87.8,144.1,87.1,92,81.2,93.1,84.4,88.7,95.7,99.3,85.3,81.8,83.6,121.7,137.3,233.7,80.8,82.9,89.9,83.7,89.4,87.6,105.3,120.8,109.5,115.1,124.1,128.8,110.6,106.2,108.5,157.9,178.1,303.2,104.8,107.6,116.7,108.6,116,113.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6P1J9","Parafibromin [OS=Homo sapiens]",34,18,40,18,531,60.5,9.61,104.49,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus","other molecular function","CDC73","ENSG00000134371","","Hedgehog 'on' state; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; E3 ubiquitin ligases ubiquitinate target proteins; Formation of the beta-catenin:TCF transactivating complex","Endoderm differentiation",0.616,0.62,0.586,0.568,0.584,93,93.7,88.5,151,85.8,88.1,93.8,92.4,95.2,95,94.4,93.8,86.8,89.2,92.9,152.2,152.6,131.8,86.5,86.3,89.7,87.6,90.9,88.9,4535.9,4471.7,4607.1,4596.4,4569.1,4539.7,4201.8,4315.5,4494.1,7364,7381.9,6378.4,4185.8,4176.9,4338.3,4235.8,4395.5,4299.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8TDD1","ATP-dependent RNA helicase DDX54 [OS=Homo sapiens]",26,14,25,14,881,98.5,10.02,77.12,"RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes","ER/Golgi;nucleus","signal transduction activity or receptor binding;other molecular function","DDX54","ENSG00000123064","","","",0.616,0.63,0.576,0.587,0.571,92.9,95,86.8,150.8,88.4,86.1,91.8,88.2,91.6,93.6,99.7,90.7,93.8,85.6,85,144.1,148.6,171.4,88.4,86.2,87.2,83.6,85.8,84.8,1304.2,1252.4,1300.7,1329,1415.9,1288.1,1332.6,1215.2,1207.2,2047,2110,2434.6,1254.8,1224.2,1237.7,1187.3,1218.7,1204.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P23025","DNA repair protein complementing XP-A cells [OS=Homo sapiens]",7,1,1,1,273,31.3,6.73,4.15,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;nucleus;other cell component","nucleic acid binding activity;other molecular function","XPA","ENSG00000136936","Platinum drug resistance; Nucleotide excision repair","Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER","Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum",0.618,0.722,0.7,0.697,0.539,86.7,101.3,98.2,140.4,97.8,75.6,74.5,85.3,111.2,99.7,88.5,109.6,109.5,67.4,96.7,108.6,138.1,160.5,96.2,96.1,96.9,70.7,116.1,74.4,28.4,32.5,42.4,38,33.7,41.8,41.8,25.7,36.9,41.4,52.7,61.2,36.7,36.6,36.9,27,44.3,28.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y597","BTB/POZ domain-containing protein KCTD3 [OS=Homo sapiens]",1,1,1,1,815,88.9,7.03,3.19,"cell organization and biogenesis","plasma membrane;other membranes","","KCTD3","ENSG00000136636","","CDC42 GTPase cycle","",0.618,0.698,0.486,0.481,0.474,98.7,111.5,77.6,159.6,76.8,75.7,95.4,94.4,86.2,111.5,106.7,99.2,87.3,74.3,74.2,152.8,150.6,237.6,73.4,74.4,73.5,58.5,72.4,77.6,127.2,126,115,148.7,142.3,132.3,116.4,99.1,99,203.7,200.9,316.9,97.9,99.2,98.1,78,96.6,103.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8N3R9-1","MAGUK p55 subfamily member 5 [OS=Homo sapiens]",6,3,4,3,675,77.2,6.14,10.09,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","MPP5; PALS1","ENSG00000072415; ENSPPAG00000036838; ENSPTRG00000006460","Hippo signaling pathway; Tight junction; Human papillomavirus infection","Tight junction interactions","Epithelial to mesenchymal transition in colorectal cancer; Complement system in neuronal development and plasticity",0.619,0.658,0.721,0.695,0.758,83.4,88.7,97.2,134.8,93.7,102.1,74.6,83,69.4,75.8,122,79.4,95.1,87,79,120.6,108.6,290.1,83.8,85.6,78.3,91.4,77.3,98.8,206.6,229.8,192.2,209.9,337.7,219.8,263.2,240.7,218.6,333.9,300.5,802.8,232,236.9,216.7,252.9,213.9,273.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O60337","E3 ubiquitin-protein ligase MARCH6 [OS=Homo sapiens]",2,2,2,2,910,102.5,6.28,5.33,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","other molecular function","MARCHF6","ENSG00000145495","Protein processing in endoplasmic reticulum","ER Quality Control Compartment (ERQC)","",0.619,0.758,0.751,0.725,0.702,81.5,99.9,98.9,131.7,95.5,92.5,76.4,76.1,78.6,93.6,103.7,92.9,92.7,88.9,92.7,120.6,123.5,229,88.7,90.5,89.5,86.6,78.9,97.1,178.8,178.2,184,219.1,242.7,217.4,216.9,207.9,217,282.2,288.9,535.9,207.7,211.7,209.4,202.8,184.6,227.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q92560","ubiquitin carboxyl-terminal hydrolase BAP1 [OS=Homo sapiens]",9,4,4,4,729,80.3,6.84,13.26,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","BAP1","ENSG00000163930","","UCH proteinases; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks","Clear cell renal cell carcinoma pathways; Malignant pleural mesothelioma",0.619,0.716,0.663,0.615,0.69,86.3,99.9,92.4,139.4,85.8,96.2,77.2,76,74.6,87.9,103.3,82.1,82.5,78.4,81.3,122.7,121.8,329.8,83.8,75.2,75.5,86.8,76.6,84.6,189.9,186.8,183.4,216.1,253.9,201.8,203,192.8,199.9,301.6,299.4,810.9,206.1,184.9,185.5,213.4,188.3,208.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O43164","E3 ubiquitin-protein ligase Praja-2 [OS=Homo sapiens]",3,1,2,1,708,78.2,4.39,6.64,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component","other molecular function","PJA2","ENSG00000198961","","Antigen processing: Ubiquitination & Proteasome degradation","",0.62,0.735,0.604,0.561,0.504,92.5,109.7,90,149.1,83.6,75.1,94.4,84.3,92.6,124.8,107.6,109.7,87.4,96.5,90.1,156,143.3,149.2,83.6,72,84.1,75.2,65.2,84,51.3,45.8,50.3,67.8,58.5,59.6,47.5,52.4,49,84.8,77.9,81.1,45.5,39.1,45.7,40.9,35.4,45.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NRR8","CDC42 small effector protein 1 [OS=Homo sapiens]",10,1,1,1,79,8.9,9.99,2.02,"transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","CDC42SE1","ENSG00000197622","","","",0.62,0.637,0.542,0.556,0.585,94.5,96.9,82.6,152.2,84.7,89.1,80.8,82.2,94.2,84.8,84.3,72.1,74.8,69.7,71.8,104.3,132.4,396.1,76.6,71.1,73.7,77.5,80.9,72.6,49.9,50.8,58.2,52.4,52.1,44.6,46.2,43,44.4,64.4,81.8,244.7,47.3,43.9,45.5,47.9,50,44.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O43493-1","Trans-Golgi network integral membrane protein 2 [OS=Homo sapiens]",37,16,34,2,480,51.1,5.73,98.24,"","","","","","","","",0.621,0.656,0.676,0.693,0.67,86.4,91.2,94,139,96.4,93.1,87.9,85.6,96.3,112,92.8,89.3,95.7,98.2,92.4,141.5,143.3,87.1,100.1,98.1,93.5,97.8,94.7,93.7,3370.1,3284.6,3692.7,4296,3558,3423.8,3670.1,3767.5,3542.8,5425.7,5494.7,3340.7,3837.4,3760.4,3586.8,3752.2,3632.7,3591.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q92503-1","SEC14-like protein 1 [OS=Homo sapiens]",10,6,8,6,715,81.2,6.43,21.87,"stress response;transport;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding","SEC14L1","ENSG00000129657","","","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway",0.621,0.683,0.681,0.622,0.597,88.7,97.4,97.1,142.7,88.7,85.3,92.9,92.1,87,101.3,104.6,99.3,93,100.9,103.6,148.3,148.6,85.2,93.7,91.2,92.2,88.6,89.2,88.3,747.5,741.7,700.2,815.1,841.7,799.2,748.5,812.5,833.7,1193.9,1196.4,686.2,754.2,734.1,742.2,713.3,718,711.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P56181-2","Isoform 2 of NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [OS=Homo sapiens]",22,7,14,7,473,51,9.17,48.09,"","","","NDUFV3","","","","",0.622,1.023,1.337,1.261,0.813,61.6,101.3,132.5,99.1,124.9,80.5,57.1,50.5,126.9,114.8,94,71.2,122.9,128.6,101.5,137.2,89.4,91.9,125.2,104.6,115.9,134,74.7,59.6,928.2,820.9,2062.1,1865.7,1527.4,1157.3,1996.7,2088.8,1648.5,2229,1452.9,1493.4,2033.8,1700,1883,2177.6,1213.7,967.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q15776","Zinc finger protein with KRAB and SCAN domains 8 [OS=Homo sapiens]",8,4,5,3,578,65.8,7.39,8.89,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZKSCAN8","ENSG00000198315","","Generic Transcription Pathway","",0.622,0.642,0.652,0.659,0.576,89.9,92.8,94.3,144.6,95.3,83.2,100.6,89.4,88.2,98.1,92.3,91.4,96.5,92.5,93.8,145,143.9,132,101.2,94.8,83.4,82,82.8,92,152.5,135.5,133.6,148.6,139.9,138.5,146.3,140.1,142.1,219.7,217.9,200.1,153.3,143.6,126.3,124.2,125.5,139.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BTE1","Dynactin subunit 5 [OS=Homo sapiens]",12,2,3,2,182,20.1,8.02,8.28,"developmental processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","","DCTN5","ENSG00000166847","Vasopressin-regulated water reabsorption; Amyotrophic lateral sclerosis; Huntington disease; Pathways of neurodegeneration; Salmonella infection","COPI-mediated anterograde transport; MHC class II antigen presentation; COPI-independent Golgi-to-ER retrograde traffic; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand","",0.622,0.613,0.609,0.588,0.585,92.9,91.5,91,149.3,87.9,87.4,88.8,77.3,87.8,81.3,127.2,86.5,86.1,83.1,87.9,141.2,74.1,274.8,81.8,83.1,84.3,82.6,77.7,94.4,349.7,304.4,345.9,320,501,340.7,339,327.2,346.4,556.2,291.7,1082.6,322.4,327.2,332.2,325.5,306.1,371.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q86WA8","Lon protease homolog 2, peroxisomal [OS=Homo sapiens]",3,3,3,3,852,94.6,7.3,5.97,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cytoplasmic organelle","other molecular function","LONP2","ENSG00000102910","","Peroxisomal protein import; Association of TriC/CCT with target proteins during biosynthesis","IL-18 signaling pathway",0.622,0.68,0.599,0.595,0.583,91.6,100,88.1,147.1,87.6,85.7,90.9,86.4,97.9,99.3,89.8,100,87.4,90.6,87.5,131.7,146.1,163.8,87,86.1,89.9,85.1,97.7,82.7,276.6,262.8,297.8,302.2,273,304,265.7,275.6,266.1,400.5,444.3,498.2,264.6,261.9,273.4,259,297.3,251.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8WU10","pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 [OS=Homo sapiens]",6,2,3,2,500,55.8,5.85,9.46,"stress response","cytoskeleton;nucleus","other molecular function","PYROXD1","ENSG00000121350","","","",0.623,0.729,0.659,0.724,0.739,83.5,97.8,88.4,134.1,97.1,99.1,78,91.9,87.1,91,102,112.7,90.2,92.2,98.8,146.4,139.9,67.8,88.4,101.2,103.9,103.4,105.3,100,282.5,332.8,315.5,329.7,369.3,408.2,326.9,334.1,357.8,530.2,506.6,245.6,320.3,366.6,376.2,374.4,381.4,362.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BVI4","Nucleolar complex protein 4 homolog [OS=Homo sapiens]",24,8,15,8,516,58.4,7.49,51.37,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","","NOC4L","ENSG00000184967; ENSG00000288146","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",0.623,0.639,0.616,0.635,0.6,90.9,93.2,89.9,145.9,92.7,87.5,89.9,90.9,84,92.1,100.2,88.6,90.4,85.3,88.9,144.2,141.7,166.1,92.2,91.6,90.6,86.6,84.5,92.3,1203.2,1216.8,1124,1233.4,1341.6,1185.8,1210.3,1142.4,1189.7,1930.9,1897.3,2223.6,1234.9,1226.5,1212.8,1158.8,1130.8,1235.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P42696","RNA-binding protein 34 [OS=Homo sapiens]",26,10,23,10,430,48.5,10.11,67.89,"","nucleus;other cell component","","RBM34","ENSG00000188739","","","",0.626,0.639,0.601,0.599,0.597,92.4,94.4,88.8,147.8,88.5,88.2,93.2,95,95.2,94.5,98.6,97,89,91.2,92.1,161.2,151.8,96.4,89.2,91,93,90.6,92.3,88.8,2372.4,2417.7,2423.6,2405.2,2511,2468.6,2266.2,2321.7,2343.9,4103.4,3864.8,2453.4,2271.7,2315.7,2366.5,2305.9,2350.1,2259.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9HBU6-1","ethanolamine kinase 1 [OS=Homo sapiens]",4,2,4,2,452,50.9,6.54,3.77,"other metabolic processes","cytosol","kinase activity;other molecular function","ETNK1","ENSG00000139163","Glycerophospholipid metabolism; Metabolic pathways","Synthesis of PE","Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids",0.627,0.721,0.673,0.604,0.619,88.6,102,95.2,141.4,85.4,87.5,83.7,89.9,92.6,103.5,100.9,124.2,91.8,96.6,100,143.5,146.3,96.1,86.7,86.2,95.8,83.2,90.2,88.8,564.3,606.5,624.7,698.2,680.1,837.3,618.8,651.6,674.4,967.9,986.7,647.9,584.8,581.3,645.8,561.2,608,599.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H814","Phosphorylated adapter RNA export protein [OS=Homo sapiens]",33,11,19,11,394,44.4,5.4,56.61,"transport;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","PHAX","ENSG00000164902","Nucleocytoplasmic transport","RNA polymerase II transcribes snRNA genes; snRNP Assembly","",0.627,0.589,0.605,0.62,0.645,92.1,86.5,88.8,146.9,91,94.7,93.6,92.2,100.1,90.2,85.6,88,96.9,90.3,84.6,152.4,149.3,111.8,98.1,92.5,92.2,96.2,102.6,83.2,1885.1,1856.8,2016.2,1816.9,1722.6,1771.6,1952,1817.6,1702.5,3069.2,3006.4,2250.9,1974.4,1863.4,1857.4,1937.8,2066.8,1675.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9P1Z2-1","Calcium-binding and coiled-coil domain-containing protein 1 [OS=Homo sapiens]",15,7,10,7,691,77.3,4.82,35.4,"cell-cell signaling;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","CALCOCO1","ENSG00000012822","","","",0.628,0.653,0.602,0.635,0.618,91,94.8,87.4,145,92.1,89.7,82.9,90.4,88.4,94.5,83.3,92,77.6,84.8,91,133.3,140.9,210.8,89.5,90.9,86.9,87.1,90.5,85.2,368.7,402.1,393.4,420.6,370.5,409.5,345.3,377.4,405.1,593.1,626.7,937.9,398,404.5,386.4,387.4,402.5,379.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y5S9","RNA-binding protein 8A [OS=Homo sapiens]",47,7,39,1,174,19.9,5.72,112.15,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","RBM8A","ENSG00000265241","Nucleocytoplasmic transport; mRNA surveillance pathway; Spliceosome","Regulation of expression of SLITs and ROBOs; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); RNA Polymerase II Transcription Termination; mRNA 3'-end processing; Transport of Mature mRNA derived from an Intron-Containing Transcript","",0.628,0.742,0.773,0.851,0.659,80.9,95.7,99.7,128.9,109.7,85,76.3,69.7,110,102.6,90.2,78,94,101.2,87.8,121.5,96.4,200.9,110.2,99.7,103.4,106.2,80.1,71.8,1159,1059.5,1671.9,1559.2,1370.3,1185.4,1427.7,1537.6,1334.2,1846.1,1465,3052.4,1673.8,1515.5,1571.1,1613.2,1217.2,1091,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96Q89-1","Kinesin-like protein KIF20B [OS=Homo sapiens]",2,3,3,3,1820,210.5,5.67,2.88,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KIF20B","ENSG00000138182","","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","Gastric cancer network 1",0.629,0.694,0.654,0.529,0.595,92,101.6,95.7,146.3,77.4,87.1,102.2,85.2,68.3,95.6,91.8,94.1,88.6,91.2,72.8,135.6,100.8,307.7,87.5,66.1,71.7,68.2,92,80.7,40.4,33.7,27,37.8,36.3,37.2,35.1,36.1,28.8,53.6,39.9,121.8,34.6,26.2,28.4,27,36.4,31.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UBF6","RING-box protein 2 [OS=Homo sapiens]",11,1,1,1,113,12.7,5.44,4.21,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","RNF7","ENSG00000114125","Ubiquitin mediated proteolysis; Human immunodeficiency virus 1 infection","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Inactivation of CSF3 (G-CSF) signaling","Apoptosis-related network due to altered Notch3 in ovarian cancer; Modulators of TCR signaling and T cell activation",0.63,0.735,0.602,0.627,0.572,90.7,105.9,86.6,144,90.3,82.4,94.4,68.4,84.1,75.7,106.7,98.2,109.2,73.6,80.4,133.6,110.8,263.1,80.4,100.7,83.8,63.6,76.5,96.9,84.6,61.3,75.4,67.8,95.6,88,97.9,66,72.1,119.8,99.3,235.8,72,90.2,75.1,57,68.6,86.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8N5B7","Ceramide synthase 5 [OS=Homo sapiens]",3,1,1,1,392,45.7,7.97,2.19,"other metabolic processes","other membranes;ER/Golgi","nucleic acid binding activity;other molecular function","CERS5","ENSG00000139624","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway","Sphingolipid de novo biosynthesis","Sphingolipid pathway; Sphingolipid metabolism: integrated pathway",0.631,0.488,0.618,0.637,0.62,94.7,73.3,92.8,150.3,95.8,93.1,104.9,71.5,90,67.4,84.8,69.6,103.2,88.2,70.5,122.6,142.8,222.8,88.2,127.6,91,71.2,88.5,95.1,38.3,26.1,32.9,24.6,31,25.4,37.7,32.2,25.8,44.8,52.2,81.4,32.2,46.6,33.3,26,32.3,34.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9ULG6","Cell cycle progression protein 1 [OS=Homo sapiens]",4,4,4,4,757,87.3,5.95,7.16,"cell cycle OR cell proliferation;other biological processes","other membranes","","CCPG1","ENSG00000260916","","","",0.631,0.711,0.667,0.606,0.606,89.7,101,94.8,142.2,86.2,86.2,90.2,89.2,82.1,98.2,100.5,103.1,94.9,94.3,90.9,149.7,131.8,141.4,84.8,97.9,85.7,85.7,80.2,99.5,207.1,204.9,188.5,225.7,230.9,236.9,218,216.6,208.9,343.8,302.9,324.9,194.7,224.8,196.9,197,184.2,228.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H444","Charged multivesicular body protein 4b [OS=Homo sapiens]",52,13,54,13,224,24.9,4.82,170.98,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","CHMP4B","ENSG00000101421","Endocytosis; Necroptosis","Macroautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; HCMV Late Events; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","",0.631,0.417,0.47,0.413,0.503,110.3,72.9,82.2,174.7,72.1,87.8,101.5,118,84.7,65.4,67.1,109.4,75.8,63.9,75.6,121.1,160.8,220.1,89.2,66.4,63,80.8,164.6,72.5,7257.5,8437.9,6057.9,4672,4794.9,7816.8,5420.4,4568.6,5405.6,8658.3,11493.7,15735.4,6378.7,4745.4,4500.5,5776.8,11763.1,5184.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8IWI9-1","MAX gene-associated protein [OS=Homo sapiens]",4,9,10,9,3026,331.6,6.79,30.8,"","","","","","","","",0.631,0.654,0.62,0.637,0.61,91.2,94.5,89.6,144.4,92.1,88.2,93.5,90.5,92,95.3,101.1,94.7,91.5,90.4,88.9,148.8,145.6,121.1,92.8,91.9,98.6,83.7,88.9,90.8,654.7,634,643.9,667.3,707.9,662.8,640.3,632.6,622.3,1042.1,1019.6,847.7,649.8,643.6,690.3,586.3,622.4,635.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P09651-2","Isoform A1-A of Heterogeneous nuclear ribonucleoprotein A1 [OS=Homo sapiens]",83,24,328,1,320,34.2,9.23,990.24,"","","","HNRNPA1","","","","",0.632,0.58,0.535,0.636,0.603,95.1,87.3,80.5,150.5,95.7,90.8,85.7,79.7,86,75.6,102.8,78.7,100.1,72.5,62.5,135.6,129.4,285.1,88,86.3,85.7,81.8,72.4,92.3,130.2,121.1,130.7,114.8,156.3,119.5,152.2,110.2,94.9,206.1,196.6,433.3,133.7,131.1,130.2,124.3,110,140.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8NB46","Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C [OS=Homo sapiens]",4,3,3,3,1076,115,6.48,10.52,"","","","ANKRD52","ENSG00000139645","","","",0.632,0.702,0.672,0.683,0.699,86.4,96,91.9,136.7,93.4,95.6,85,84.3,89,95.3,94.4,88.9,97.3,88.2,90.3,130.7,134.4,173.8,93.5,83.6,91.8,93.9,94.4,91.3,254.6,252.6,266.9,285.6,282.9,266.4,291.5,264.4,270.7,391.6,402.7,521,280.2,250.7,275.1,281.5,283,273.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q92805","Golgin subfamily A member 1 [OS=Homo sapiens]",5,3,4,3,767,88.1,5.27,12.7,"","other membranes;cytosol;ER/Golgi;other cell component","","GOLGA1","ENSG00000136935","","Retrograde transport at the Trans-Golgi-Network","",0.632,0.664,0.638,0.658,0.609,90.3,94.8,91.1,142.8,94,87,87.8,86.3,91.6,91.2,92.3,101.3,92.3,88.1,88.6,117,138.9,198.5,95.6,85.2,91.4,80,84.6,89.3,147.4,144.8,153.6,153,154.8,170,155,147.8,148.8,196.4,233.1,333.1,160.5,143,153.4,134.2,142,149.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P10244","Myb-related protein B [OS=Homo sapiens]",3,2,2,2,700,78.7,6.87,2.46,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","nucleus","nucleic acid binding activity;other molecular function","MYBL2","ENSG00000101057","Cellular senescence","Polo-like kinase mediated events; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1","Gastric cancer network 1; EGF/EGFR signaling pathway",0.633,0.617,0.601,0.615,0.677,91.7,89.3,87,144.8,89.1,98,79.7,93.1,110,64.9,90.6,96.1,90.6,85.5,88.3,140,147,156.9,104.3,75.3,90.4,107.6,80.4,99.5,43.8,51.2,60.5,35.7,49.9,52.9,49.8,47,48.6,77,80.8,86.3,57.4,41.4,49.7,59.2,44.2,54.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q68DK7","male-specific lethal 1 homolog [OS=Homo sapiens]",2,1,1,1,614,67.1,8.92,2.27,"protein metabolism;other metabolic processes","nucleus","other molecular function","MSL1","ENSG00000188895","","HATs acetylate histones","",0.634,0.797,0.65,0.741,0.642,85.2,107.1,87.4,134.4,99.6,86.3,71.8,58.6,164.1,67.8,110.3,90.2,73.6,116.8,60.9,113.2,90.7,310.3,74.4,83.8,86.8,94.1,72.6,60.1,17.5,14.3,40,16.5,26.9,22,18,28.5,14.9,27.6,22.1,75.7,18.2,20.5,21.2,23,17.7,14.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P30291-1","Wee1-like protein kinase [OS=Homo sapiens]",6,3,3,3,646,71.6,6.77,3.92,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","kinase activity;other molecular function","WEE1","ENSG00000166483","Cell cycle; Human immunodeficiency virus 1 infection","Factors involved in megakaryocyte development and platelet production; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Cyclin A/B1/B2 associated events during G2/M transition; Polo-like kinase mediated events; G2/M DNA replication checkpoint; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry","Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control",0.634,0.577,0.661,0.658,0.631,91.5,83.2,95.3,144.2,94.9,91,91,95.7,90.1,90.9,82.8,80.8,94.9,98.2,85.6,128.5,143.5,146.1,91,103.7,94.4,90.5,89.4,102.7,202.9,213.3,200.8,202.6,184.5,180.1,211.5,219,190.8,286.4,319.9,325.6,202.9,231.2,210.5,201.8,199.2,228.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O00124-1","UBX domain-containing protein 8 [OS=Homo sapiens]",8,1,1,1,270,30.5,7.78,3.78,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","UBXN8","ENSG00000104691; ENSPTRG00000049759","Protein processing in endoplasmic reticulum","","",0.634,0.927,0.51,0.694,0.788,83.6,122.2,67.2,131.8,91.5,103.8,88.5,79.4,82.5,128.5,75.3,120.5,106.2,60.7,66.3,130,80.5,200.3,90.3,95.9,80.3,88.7,123.7,102.4,13.8,12.4,12.9,20,11.7,18.8,16.6,9.5,10.3,20.3,12.5,31.2,14.1,15,12.5,13.8,19.3,16,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BQD7","Protein FAM173A [OS=Homo sapiens]",3,1,2,1,235,25.1,9.32,4.01,"protein metabolism;other metabolic processes;other biological processes","other membranes;mitochondrion","other molecular function","ANTKMT","ENSG00000103254","","","",0.636,0.633,0.626,0.596,0.62,92.8,92.3,91.3,145.9,87,90.5,95.6,94.9,100.2,97.1,80.4,95,89.6,95.2,94,150.3,165.9,88.9,89.6,97.6,86.5,92.4,93.2,93.6,284.7,282.4,298.4,289.1,239.4,283,266.9,283.4,279.9,447.4,493.9,264.8,266.9,290.8,257.5,275.1,277.6,278.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P35568","Insulin receptor substrate 1 [OS=Homo sapiens]",3,3,5,3,1242,131.5,8.54,11.72,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","IRS1","ENSG00000169047","cGMP-PKG signaling pathway; FoxO signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Neurotrophin signaling pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Regulation of lipolysis in adipocytes; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; Growth hormone synthesis, secretion and action; Aldosterone-regulated sodium reabsorption; Alzheimer disease; MicroRNAs in cancer; Diabetic cardiomyopathy","RAF/MAP kinase cascade; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by ALK fusions and activated point mutants; PI3K Cascade; Interleukin-7 signaling; PI3K/AKT activation; Signaling by ALK; Growth hormone receptor signaling; Signaling by Leptin; SOS-mediated signalling; IRS activation; Signal attenuation; Activated NTRK3 signals through PI3K","Type II diabetes mellitus; Integrated breast cancer pathway; Leptin signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; AGE/RAGE pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Transcription factor regulation in adipogenesis; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; PI3K-Akt signaling pathway; Nonalcoholic fatty liver disease; Gastrin signaling pathway; Insulin signaling; FOXA2 pathway; Neuroinflammation and glutamatergic signaling; Congenital generalized lipodystrophy (CGL); Alzheimer's disease; EPO receptor signaling; Interferon type I signaling pathways; DNA damage response (only ATM dependent)",0.637,0.668,0.618,0.627,0.618,91.7,96.1,88.9,144,90.3,89,90.4,86.3,96.7,95.9,91.2,94.8,87.2,87.7,89.7,142,139.7,164.4,89,90.5,88.7,87.8,84.4,93.5,342.8,327.3,366.6,363.6,345.7,359.4,330.5,332.5,340.2,538.4,529.7,623.2,337.5,343.1,336.1,332.9,320,354.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P51965-1","Ubiquitin-conjugating enzyme E2 E1 [OS=Homo sapiens]",26,4,18,3,193,21.4,8.53,61.34,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","LOC101359889; LOC101586133; LOC102160336; LOC102380731; LOC102540481; LOC112397773; LOC112849581; Ube2e1; UBE2E1","ENSAMEG00000003515; ENSANAG00000034758; ENSCAFG00000005774; ENSCANG00000033360; ENSCATG00000032614; ENSCPOG00000002251; ENSCPRG00005002140; ENSCSAG00000009770; ENSG00000170142; ENSGGOG00000008393; ENSLAFG00000004150; ENSLCNG00005011685; ENSMLEG00000038400; ENSMNEG00000039247; ENSNLEG00000003557; ENSOANG00000044336; ENSOCUG00000006026; ENSOGAG00000007527; ENSPANG00000031728; ENSPCOG00000023739; ENSPPAG00000039295; ENSPPYG00000014067; ENSPTXG00000015919; ENSRBIG00000034290; ENSRFEG00010011222; ENSRROG00000029547; ENSSBOG00000027996; ENSSSCG00000026488; ENSSSCG00070018080; ENSSSUG00005002544; ENSSTOG00000025799; ENSUAMG00000015531; ENSUMAG00000018601; ENSVVUG00000028240","Ubiquitin mediated proteolysis","Antigen processing: Ubiquitination & Proteasome degradation; E3 ubiquitin ligases ubiquitinate target proteins; Separation of Sister Chromatids; ISG15 antiviral mechanism; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Senescence-Associated Secretory Phenotype (SASP); Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; APC-Cdc20 mediated degradation of Nek2A; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Phosphorylation of the APC/C; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; ISG15 antiviral mechanism; APC-Cdc20 mediated degradation of Nek2A; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; APC/C:Cdc20 mediated degradation of Securin; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Photodynamic therapy-induced unfolded protein response; 7q11.23 copy number variation syndrome",0.637,0.686,0.655,0.701,0.679,87.7,94.5,90.1,137.7,96.5,93.5,84.5,86.1,85.5,92.1,96.7,88.9,91.3,86.7,87.9,134.2,132.8,174.9,92.5,94.5,94.1,90.8,91.2,95.4,1353.7,1380.7,1370,1476.4,1549.8,1424.9,1463.2,1389,1408.7,2151.3,2129.1,2803.9,1482.3,1515.4,1507.6,1455,1461.7,1528.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q14CW9-1","Ataxin-7-like protein 3 [OS=Homo sapiens]",3,1,1,1,347,38.6,7.03,2.8,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","ATXN7L3","ENSG00000087152; ENSMLEG00000031775; ENSMMUG00000019923; ENSRBIG00000028756","","HATs acetylate histones","",0.637,0.629,0.515,0.509,0.508,100.7,99.3,81.3,158,80.4,80.2,98.9,80.4,96.1,78.2,94.9,101.6,98.9,69.6,77.7,146.3,151,210.3,70.7,76.8,111.5,64.6,76.7,95.9,68.8,55.9,66.9,54.4,66,70.7,68.9,48.4,54.1,101.8,105.1,146.3,49.2,53.5,77.6,45,53.3,66.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O14641","Segment polarity protein dishevelled homolog DVL-2 [OS=Homo sapiens]",6,4,6,2,736,78.9,6.02,11.66,"cell-cell signaling;cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","DVL2","ENSG00000004975","mTOR signaling pathway; Wnt signaling pathway; Notch signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer","RHO GTPases Activate Formins; Asymmetric localization of PCP proteins; Degradation of DVL; Cargo recognition for clathrin-mediated endocytosis; WNT mediated activation of DVL; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Negative regulation of TCF-dependent signaling by DVL-interacting proteins; WNT5:FZD7-mediated leishmania damping; Signaling by Hippo; WNT5A-dependent internalization of FZD4","Alzheimer's disease and miRNA effects; Neural crest differentiation; Notch signaling; Wnt signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Type 2 papillary renal cell carcinoma; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Malignant pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)",0.637,0.705,0.748,0.619,0.658,87.6,96.8,102.8,137.4,85.1,90.4,85.4,78,83.3,92.1,97.5,88.2,101,87.1,97.7,124.4,130.7,231.3,80.9,85.5,79.5,84.3,87.2,85.9,173,158.2,168.8,186.6,197.7,178.7,204.7,176.5,198,252.2,264.8,468.8,163.9,173.2,161.2,170.8,176.7,174.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q53GL0-1","pleckstrin homology domain-containing family O member 1 [OS=Homo sapiens]",10,3,4,3,409,46.2,8.82,9.24,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;nucleus;other cell component","","PLEKHO1","ENSG00000023902","","","",0.637,0.653,0.687,0.65,0.69,88.6,90.7,95.5,139,90.3,95.9,84.2,84.9,85.3,77.8,86.9,87.1,78,92.2,91.5,133.2,130.2,234.3,88.7,79.5,86.5,98.2,91.8,89.6,136.2,137.2,138,125.8,140.6,140.8,126.2,149.1,148,215.3,210.6,378.9,143.5,128.6,139.9,158.8,148.5,144.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q13206","probable ATP-dependent RNA helicase DDX10 [OS=Homo sapiens]",17,13,19,13,875,100.8,8.63,45.5,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","DDX10","ENSG00000178105","","","",0.637,0.659,0.656,0.678,0.651,89.3,92.3,92,140.1,95,91.2,85.6,82.9,82.1,85.6,87.3,80.2,85.3,85.4,82.2,130,128.9,266.5,90.8,84.7,88.1,84.6,85.9,84,1700.3,1646.1,1631.7,1701.1,1733.4,1593.6,1694.7,1695.6,1632.3,2582.2,2561.1,5293.2,1803.1,1681.8,1750.1,1681,1705.9,1668.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q5UIP0","Telomere-associated protein RIF1 [OS=Homo sapiens]",17,35,47,35,2472,274.3,5.52,132.33,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","","RIF1","ENSG00000080345","Signaling pathways regulating pluripotency of stem cells","Nonhomologous End-Joining (NHEJ)","ATM signaling in development and disease",0.638,0.595,0.616,0.66,0.66,91.8,85.6,88.7,144,95,95,92.3,90.2,92.8,86,87,86,88.8,90.7,89.1,144.7,151.2,127.6,95.5,95.8,95.5,95.2,96.2,95.4,4215.6,4119.5,4241.1,3929.2,3977.5,3930.2,4059,4146,4071.7,6610.8,6908.3,5829.9,4364.6,4378.2,4362.1,4348.8,4395.7,4361.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8N2W9","E3 SUMO-protein ligase PIAS4 [OS=Homo sapiens]",10,4,11,4,510,56.5,6.14,32.62,"cell-cell signaling;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","PIAS4","ENSG00000105229","NF-kappa B signaling pathway; Ubiquitin mediated proteolysis; JAK-STAT signaling pathway; Fluid shear stress and atherosclerosis","SUMOylation of intracellular receptors; Nonhomologous End-Joining (NHEJ); SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of DNA replication proteins; Processing of DNA double-strand break ends; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; G2/M DNA damage checkpoint; SUMOylation of transcription cofactors; Vitamin D (calciferol) metabolism; SUMOylation of transcription factors; SUMOylation of immune response proteins","Androgen receptor signaling pathway",0.638,0.73,0.647,0.647,0.638,89,101.9,90.3,139.5,90.3,89,87.9,88.5,91.6,101,106,101.3,89.8,89.8,94,142.2,138.7,136.6,85.5,89.8,91.3,85.8,88.4,91.9,720.4,725.2,751.3,828,868.9,830.2,735.9,736.1,771,1165.9,1137.1,1120,701.1,736,748.4,703.8,724.9,753.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q13137-1","Calcium-binding and coiled-coil domain-containing protein 2 [OS=Homo sapiens]",31,11,15,11,446,52.2,5.02,44.64,"other metabolic processes;stress response;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","CALCOCO2","ENSG00000136436","Mitophagy; Shigellosis; Influenza A","","",0.638,0.669,0.619,0.61,0.614,92.3,96.7,89.4,144.6,88.2,88.7,89.2,92.6,90.8,87.7,95.2,103.1,94.9,82.3,88,140.2,142.3,170.4,87.9,85.7,86.8,83.1,92.6,87.3,1061.4,1101.7,1081.2,1043.7,1133.1,1227.4,1129.8,979.4,1047.4,1668.5,1693.5,2028.1,1045.9,1020.4,1033.5,988.6,1102.5,1039.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96BK5","PIN2/TERF1-interacting telomerase inhibitor 1 [OS=Homo sapiens]",23,6,8,6,328,37,9.6,22.75,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","cytoskeleton;mitochondrion;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","PINX1","ENSG00000254093","","","",0.639,0.673,0.718,0.758,0.631,86.8,91.4,97.5,135.8,102.9,85.7,85,82,104.6,99.8,89.5,88.6,95.5,101,92.9,133,125.7,135.1,94.6,100.8,105.9,100.8,83.9,81.1,785.1,757.4,966.4,922.3,826.8,818.5,882.5,933.5,858.5,1229.2,1161.5,1248.3,873.9,931.1,978.7,930.9,775.3,749.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BY43","Charged multivesicular body protein 4a [OS=Homo sapiens]",31,6,11,6,222,25.1,4.7,34.79,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","CHMP4A","ENSG00000254505; ENSG00000285302","Endocytosis; Necroptosis","HCMV Late Events; Late endosomal microautophagy; Pyroptosis; Sealing of the nuclear envelope (NE) by ESCRT-III; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","",0.639,0.472,0.502,0.439,0.527,107.1,79.1,84.1,167.6,73.6,88.3,101.5,118.6,91.3,73.8,75,113.7,79.7,66.7,80.4,123.1,158.8,173.1,87.5,69.8,67.1,83.6,156.1,80.2,1304,1525,1174.1,948.2,963.5,1462,1024.4,857.1,1033.6,1582,2041.1,2224.5,1125.2,896.7,861.9,1075.2,2007.1,1031,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9GZU8","Protein FAM192A [OS=Homo sapiens]",33,7,10,7,254,28.9,5.45,17.77,"other biological processes","nucleus","","PSME3IP1","ENSG00000172775","","","",0.639,0.809,0.9,0.94,0.755,76,96.3,107,119,111.9,89.8,74.4,71.2,112.5,98.9,94.2,84.4,104.7,115.4,102.1,143.8,116.4,80.5,109.4,94.7,113.9,116.3,87.9,79.5,791,756.8,1196.3,1051.1,1001.4,897.4,1113.2,1226.5,1085.2,1528.8,1237.5,856.1,1163.7,1006.4,1211,1236.2,934.6,845.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q92576-1","PHD finger protein 3 [OS=Homo sapiens]",11,13,21,13,2039,229.3,6.96,77.84,"RNA metabolism OR transcription;other metabolic processes;developmental processes","","other molecular function","PHF3","ENSG00000118482","","","",0.64,0.686,0.617,0.622,0.609,92,98.7,88.7,143.8,89.4,87.5,88.8,86.5,87.3,93.7,96.1,89.7,84.2,85.6,82.7,132.6,136.5,232.6,84.8,82.8,87.8,83.1,81.6,83.7,1383.9,1348.1,1360.9,1459.8,1498,1397.4,1311.5,1334.2,1288.4,2066.4,2126.5,3624.3,1321.8,1291,1367.5,1294.4,1271.5,1304,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P19404","NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [OS=Homo sapiens]",19,4,16,4,249,27.4,8.06,36.95,"other metabolic processes;transport;developmental processes","other membranes;cytosol;mitochondrion;nucleus","transporter activity;other molecular function","NDUFV2","ENSG00000178127","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",0.641,0.521,0.591,0.578,0.654,96.5,78.4,89,150.6,87,98.5,94,93.6,89.8,76,68.3,98.6,88.9,80.2,86.3,133.9,146,189.7,90.9,84.3,81.3,95.5,119,83.6,836.1,831.9,798.6,675.7,607.6,876.9,790.9,712.9,767.6,1190.2,1298,1686.7,808,749.9,722.9,849.4,1057.8,743.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NUS5","AP-5 complex subunit sigma-1 [OS=Homo sapiens]",6,1,1,1,200,22.5,6.87,2.33,"DNA metabolism;stress response;transport","other membranes;cytosol;nucleus;other cytoplasmic organelle","","AP5S1","ENSG00000125843","","","",0.641,0.728,0.804,0.677,0.665,85.2,96.7,106.9,132.9,90,88.3,119.8,77.6,78,88.5,96.3,84.5,96.9,108.2,97.8,121.6,95.4,236.7,85.2,75.2,82.4,80.8,58.2,116.8,204.6,132.4,133.2,151.1,164.3,144.2,165.4,184.7,167,207.6,162.9,404,145.4,128.4,140.6,138,99.4,199.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P42677","40S ribosomal protein S27 [OS=Homo sapiens]",39,4,23,2,84,9.5,9.45,63.58,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;translational apparatus;nucleus;other cell component","nucleic acid binding activity;other molecular function","RPS27","ENSG00000177954","Ribosome; Coronavirus disease","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Genotoxicity pathway; Cytoplasmic ribosomal proteins",0.642,0.647,0.645,0.653,0.633,91.3,91.9,91.8,142.2,92.9,89.9,103.7,85.1,83.5,85.7,94.2,84,104.2,85.6,76.8,132.6,110.5,219.5,86.6,107.1,83.6,79,83.9,94.3,3264.3,2678.4,2626,2697.6,2965.6,2643.2,3279.7,2693.1,2417.3,4172.4,3476.3,6906.9,2725.6,3370.3,2631.2,2485.9,2639.1,2968.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P13674-2","Isoform 2 of Prolyl 4-hydroxylase subunit alpha-1 [OS=Homo sapiens]",27,13,20,13,534,60.9,6.01,58.99,"","","","P4HA1","","","","",0.642,0.768,0.761,0.67,0.726,84.3,100.9,100,131.4,88,95.4,82.7,84.5,85.1,105.5,101.1,89.9,108.2,98.9,100.3,131.7,135.4,124.9,88.2,88.1,87.5,95.6,89.8,102.5,1825.7,1865.8,1879.1,2329.7,2231.4,1984.5,2388.3,2183.6,2212.9,2906,2989.1,2757.7,1946.9,1945.6,1930.4,2110.6,1981.8,2262.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6ZS11","Ras and Rab interactor-like protein [OS=Homo sapiens]",4,1,1,1,566,62.4,5.92,3.52,"transport","other cell component","enzyme regulator activity","RINL","ENSG00000187994; ENSG00000282895","","RAB GEFs exchange GTP for GDP on RABs","",0.642,0.689,1.024,0.935,0.956,73.5,78.8,117.1,114.4,106.9,109.3,79.1,75.3,45.7,79.8,80.7,89.5,126.8,120,78.2,101.4,117.2,148.4,94.7,109.6,111.8,91.4,138.4,112,13.7,13,7.9,13.8,14,15.5,22,20.8,13.5,17.6,20.3,25.7,16.4,19,19.4,15.8,24,19.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UJK0","Ribosome biogenesis protein TSR3 homolog [OS=Homo sapiens]",18,4,5,4,312,33.6,6.87,16.39,"RNA metabolism OR transcription;other metabolic processes","cytosol","other molecular function","TSR3","ENSG00000007520","","rRNA modification in the nucleus and cytosol","",0.645,0.733,0.682,0.704,0.683,87,98.9,92,134.9,95,92.1,81.2,76.4,80.1,91.1,92.4,82.6,78.7,85.4,84.7,119,124.2,288.3,89.9,87.5,83.1,83,84.8,87.6,400,376.2,394.6,448.5,455,407,387.6,420.3,417.3,586,611.8,1419.7,442.7,431,409.3,408.6,417.6,431.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O43310-2","Isoform 2 of CBP80/20-dependent translation initiation factor [OS=Homo sapiens]",15,6,7,1,600,67.7,6.54,15.96,"","","","CTIF","","","","",0.645,0.814,0.67,0.668,0.662,86.8,109.5,90.2,134.5,89.9,89,71.4,65.5,66.3,93.3,83.6,60.4,68.9,64.5,71.4,102.7,63.6,570,65.7,68.7,70.6,68,65.1,80.3,26.4,24.2,24.5,34.5,30.9,22.3,25.4,23.8,26.4,38,23.5,210.6,24.3,25.4,26.1,25.1,24.1,29.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UJA3","DNA helicase MCM8 [OS=Homo sapiens]",5,3,5,2,840,93.6,7.75,8.51,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","MCM8","ENSG00000125885","","CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation; Unwinding of DNA","Ciliary landscape",0.646,0.774,0.679,0.645,0.641,88.4,105.9,93,136.9,88.2,87.7,89,87.4,92.4,84.4,106.7,120.8,74.7,93.7,95.2,143.8,137.9,130,89,87.2,88.9,106.8,83.9,88.4,44.7,43.9,46.4,42.4,53.6,60.6,37.5,47,47.8,72.2,69.3,65.3,44.7,43.8,44.6,53.6,42.1,44.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q5JSZ5-1","Protein PRRC2B [OS=Homo sapiens]",4,9,15,8,2229,242.8,8.34,30.2,"other biological processes","","","PRRC2B","ENSG00000288701","","","",0.646,0.648,0.626,0.63,0.615,93.1,93.3,90.2,144.1,90.7,88.6,91.4,89.3,87,89.5,91.2,89.4,86.6,86.5,85.2,133.5,138.2,216,86.1,87.1,89.9,87,85,81,736.6,719.9,701,721.2,735.1,720.3,697.4,697.1,686.6,1075.6,1113.8,1740.5,693.9,701.5,724.2,700.6,684.9,652.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96ST8","Centrosomal protein of 89 kDa [OS=Homo sapiens]",1,1,1,1,783,89.5,6.8,1.64,"cell-cell signaling;cell organization and biogenesis","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component","","CEP89","ENSG00000121289","","Anchoring of the basal body to the plasma membrane","",0.646,0.672,0.578,0.592,0.604,94.8,98.5,84.8,146.6,86.8,88.5,94.3,86.1,109,98,79.4,112.4,80,84.4,92.9,118.3,145.8,174.9,72.5,95.1,86.4,95.7,86.8,88.1,35.1,32.1,40.6,36.5,29.6,41.9,29.8,31.4,34.6,44.1,54.4,65.2,27,35.4,32.2,35.7,32.4,32.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q13286-1","Battenin [OS=Homo sapiens]",4,1,1,1,438,47.6,6.38,0,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","CLN3","ENSG00000188603","Lysosome","","",0.646,0.612,0.688,0.784,0.675,88,83.4,93.7,136.2,106.7,92,86.8,101.1,90,114,85.3,71.5,100.4,94.4,95.9,112.2,141.2,139.3,109.1,109.1,80,97.5,94,78.2,49.5,57.6,51.3,64.9,48.6,40.8,57.2,53.8,54.6,63.9,80.5,79.4,62.2,62.2,45.6,55.6,53.6,44.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NVE5","Ubiquitin carboxyl-terminal hydrolase 40 [OS=Homo sapiens]",1,1,1,1,1235,140,5.67,0,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","USP40","ENSG00000085982","","","",0.647,0.761,0.866,0.727,0.942,78.5,92.3,105.1,121.4,88.3,114.4,75.9,99.3,73.6,104.3,89.3,79.1,81.6,113.2,101.7,104.9,117.3,171.4,77.9,85.4,87.3,100.1,110.6,127.2,54,70.6,52.4,74.2,63.5,56.2,58,80.5,72.3,74.6,83.4,121.8,55.4,60.7,62.1,71.1,78.6,90.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P06858","lipoprotein lipase [OS=Homo sapiens]",1,1,1,1,475,53.1,8.15,1.76,"cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","LPL","ENSG00000175445","Glycerolipid metabolism; PPAR signaling pathway; Cholesterol metabolism; Alzheimer disease","Transcriptional regulation of white adipocyte differentiation; Retinoid metabolism and transport; Assembly of active LPL and LIPC lipase complexes; Chylomicron remodeling","Fatty acid beta-oxidation; Sterol regulatory element-binding proteins (SREBP) signaling; Alzheimer's disease and miRNA effects; Adipogenesis; Aryl hydrocarbon receptor Netpath; Triacylglyceride synthesis; Lipid particles composition; Angiopoietin-like protein 8 regulatory pathway; PPAR signaling pathway; Statin inhibition of cholesterol production; Metabolic pathway of LDL, HDL and TG, including diseases; Overview of leukocyte-intrinsic Hippo pathway functions; Orexin receptor pathway; Familial partial lipodystrophy (FPLD); Familial  hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5; Alzheimer's disease; Vitamin A and carotenoid metabolism",0.647,0.756,0.842,0.739,0.849,80.4,93.9,104.5,124.2,91.7,105.4,78.9,111.7,77.9,101.4,86.2,92.2,98,115.6,102.6,105.4,122,121.9,91.6,90,83.7,115.9,101.8,103.4,58.9,83.5,58.2,75.7,64.4,68.8,73.2,86.3,76.6,78.7,91.2,91,68.5,67.2,62.5,86.6,76,77.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UJJ9","N-acetylglucosamine-1-phosphotransferase subunit gamma [OS=Homo sapiens]",7,1,5,1,305,34,6.95,20.03,"other metabolic processes","other membranes;ER/Golgi","other molecular function","GNPTG","ENSG00000090581","Lysosome","","",0.648,0.684,0.573,0.785,0.694,88.6,93.6,78.4,136.9,107.5,94.9,117,84.8,76.7,89.6,93.5,65.8,96.7,75,73.5,130.9,110.1,183.1,102.8,129.1,85.1,84.9,90.8,110.5,62,44.9,40.6,47.5,49.6,34.9,51.2,39.7,39,69.4,58.3,97,54.5,68.4,45.1,45,48.1,58.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UH17-1","DNA dC->dU-editing enzyme APOBEC-3B [OS=Homo sapiens]",21,6,14,4,382,45.9,6.06,42.85,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","other molecular function","APOBEC3B","ENSG00000179750","Human immunodeficiency virus 1 infection","Formation of the Editosome","",0.648,0.807,0.688,0.681,0.69,86.1,107.2,91.5,132.9,90.5,91.7,85.2,87.3,89.7,89,108.7,109.3,86.1,95.4,92.7,153,134.7,109.3,91.7,88.3,100,88.2,98.7,92.9,435.1,445.8,458.4,454.7,555.2,558.4,439.9,487.3,473.5,781.6,688.1,558.5,468.6,451.3,510.8,450.6,504.2,474.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P37268","squalene synthase [OS=Homo sapiens]",35,12,27,12,417,48.1,6.54,82.7,"other metabolic processes","other membranes;ER/Golgi","other molecular function","FDFT1","ENSG00000079459","Steroid biosynthesis; Metabolic pathways","PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Statin inhibition of cholesterol production; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways",0.648,0.661,0.675,0.723,0.676,88.7,90.5,92.3,136.9,98.9,92.6,89.1,87.2,88.6,88.1,98.8,90.4,92.2,90.5,94.3,157.8,136.7,108.6,94.1,100.5,98.8,88.6,92.5,103,1631.7,1597.6,1623.2,1614.6,1810.1,1655.8,1689.6,1658.6,1728,2890.7,2504.8,1989.8,1723.4,1840.4,1810.2,1623.2,1694,1886.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q13111-1","Chromatin assembly factor 1 subunit A [OS=Homo sapiens]",16,14,18,14,956,106.9,5.94,41.17,"","","","","","","","",0.648,0.634,0.663,0.65,0.68,91,89,93,140.4,91.2,95.4,90.9,91,94.5,88.9,93.3,89.1,91.9,93.1,94.2,140.5,141.6,129.5,96.3,88.7,91.3,95.5,96.5,93.3,1624.1,1627.4,1688.6,1588.9,1668.1,1591.9,1641.9,1664.3,1684.3,2511,2530.9,2315.1,1721.4,1584.9,1631.6,1706.3,1725.4,1668,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6PIY7-2","Isoform 2 of Poly(A) RNA polymerase GLD2 [OS=Homo sapiens]",1,1,1,1,480,55.5,9.42,2.23,"","","","TENT2","","","","",0.648,0.804,0.583,0.678,0.511,92.1,114.2,82.8,142,96.3,72.5,81.5,79.4,85.7,101.1,101.9,98.8,69.6,73.3,77,125.7,108.6,344.3,86.5,80.7,85.2,75.3,64.2,61.2,67.3,65.6,70.8,83.5,84.2,81.6,57.5,60.6,63.6,103.8,89.7,284.5,71.4,66.7,70.4,62.2,53,50.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P35520-1","Cystathionine beta-synthase [OS=Homo sapiens]",15,5,6,5,551,60.5,6.65,18.08,"DNA metabolism;other metabolic processes;stress response","nucleus;other cell component","other molecular function","CBS","ENSG00000160200","Glycine, serine and threonine metabolism; Cysteine and methionine metabolism; Metabolic pathways; Biosynthesis of amino acids","Cysteine formation from homocysteine; Metabolism of ingested SeMet, Sec, MeSec into H2Se","Selenium micronutrient network; Vitamin B12 metabolism; Folate-alcohol and cancer pathway hypotheses; Folate metabolism; Trans-sulfuration pathway; Trans-sulfuration and one-carbon metabolism; Vitamin D receptor pathway; Amino acid metabolism; Methionine metabolism leading to sulfur amino acids and related disorders; Ciliary landscape",0.648,0.658,0.74,0.745,0.77,85.3,86.5,97.3,131.5,98,101.3,88,93.1,82.4,89.3,80.9,100.2,89.3,100.4,100.7,156.4,135.7,71.4,103.2,100.6,101.1,104.5,106.2,96.4,448.7,474.9,420.4,455.2,412.7,511.1,455.4,512.1,513.7,797.4,691.9,364.2,526.4,513,515.5,533.1,541.5,491.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6SJ93-1","Protein FAM111B [OS=Homo sapiens]",15,12,32,12,734,84.6,8.59,75.35,"protein metabolism;other metabolic processes","nucleus;other cell component","other molecular function","FAM111B","ENSG00000189057","","","",0.649,0.611,0.613,0.66,0.654,93,87.6,87.8,143.3,94.6,93.7,94.5,94.5,91.2,88.9,93.7,89,89.3,89.2,90.9,147.6,145.7,109.2,96.9,96.1,96.2,95.3,99.3,92.5,3115.4,3115,3004.8,2928.7,3086,2933.2,2941.5,2940.2,2995.8,4863.5,4801,3598.7,3193.7,3167.6,3169.1,3138.8,3270.5,3046.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q14690","Protein RRP5 homolog [OS=Homo sapiens]",18,30,70,30,1871,208.6,8.87,196.8,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","PDCD11","ENSG00000148843","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",0.649,0.689,0.623,0.623,0.595,93.2,98.9,89.5,143.6,89.4,85.5,94.2,92.9,95.8,95.4,102.1,100,90.5,90.1,91.4,157.1,145.2,115.2,89.6,90.4,91,86.4,87.5,84.9,7017.5,6916.1,7132.5,7101.6,7603.1,7449.4,6739.1,6707.3,6809,11697.6,10815.3,8580.2,6673.8,6732.8,6773.8,6436.4,6518.9,6324.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O75438","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [OS=Homo sapiens]",19,1,3,1,58,7,8.92,7.18,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB1","ENSG00000183648","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",0.649,0.518,0.482,0.466,0.614,104.4,83.3,77.6,160.9,75,98.8,84.2,102.6,100.5,68.3,80.2,130.4,74.7,52.9,75.3,79.3,154.8,242.7,94.3,59.7,72.2,95,153.5,79.3,283.3,345.3,338.2,230,269.8,438.9,251.2,178,253.5,266.8,521.1,816.7,317.5,200.9,242.9,319.8,516.8,267,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8N9Z2-1","Coiled-coil domain-containing protein 71L [OS=Homo sapiens]",4,1,1,1,235,26.2,11.71,3.05,"other metabolic processes;other biological processes","","","CCDC71L","ENSG00000253276","","","",0.649,0.649,0.612,0.604,0.651,93.5,93.5,88.2,144.1,87,93.7,81.7,91.3,91.9,91.3,95.6,81.8,87.8,86,78.5,134.7,140.6,197.4,97.7,84.9,78.5,91.5,102.6,86.1,104.3,116.5,117.4,116.5,122.1,104.4,112.1,109.8,100.3,172,179.5,252,124.7,108.4,100.2,116.8,130.9,109.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UIA0","Cytohesin-4 [OS=Homo sapiens]",13,3,5,2,394,45.6,6.47,11,"other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi","enzyme regulator activity;other molecular function","CYTH4","ENSG00000100055","Phospholipase D signaling pathway; Endocytosis; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection","Intra-Golgi traffic","",0.65,0.638,0.687,0.686,0.755,88.3,86.7,93.3,135.9,93.2,102.6,104.8,88.6,85.1,112.5,87,86.6,87.1,93.6,117.1,142.9,136.3,69,90.2,105.8,93.5,93.1,103.8,102.9,20.9,17.6,16.9,22.4,17.3,17.2,17.3,18.6,23.3,28.4,27.1,13.7,18,21,18.6,18.5,20.6,20.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96JM7","Lethal(3)malignant brain tumor-like protein 3 [OS=Homo sapiens]",6,3,4,3,780,88.3,6.46,11.11,"cell organization and biogenesis;developmental processes;other biological processes","nucleus","other molecular function","L3MBTL3","ENSG00000198945","","","",0.65,0.738,0.72,0.699,0.748,85.6,97.2,94.8,131.7,92.2,98.5,87,79.9,80.2,74.9,91,92.3,95.5,88.8,83,123.4,114.4,232.9,84.1,105,86.3,92.3,90.8,98,114.3,104.9,105.4,98.4,119.5,121.2,125.5,116.6,109.1,162.1,150.3,305.9,110.5,137.9,113.4,121.2,119.2,128.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P01130","Low-density lipoprotein receptor [OS=Homo sapiens]",20,16,21,16,860,95.3,5.05,57.91,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","LDLR","ENSG00000130164","Endocytosis; Ovarian steroidogenesis; Aldosterone synthesis and secretion; Cortisol synthesis and secretion; Cushing syndrome; Bile secretion; Cholesterol metabolism; Toxoplasmosis; Hepatitis C; Lipid and atherosclerosis","Retinoid metabolism and transport; Cargo recognition for clathrin-mediated endocytosis; LDL clearance; Chylomicron clearance","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Oncostatin M signaling pathway; PCSK9-mediated LDL receptor degradation; Evolocumab mechanism to reduce LDL cholesterol; Lipid particles composition; Wnt signaling pathway and pluripotency; Statin inhibition of cholesterol production; Bile acids synthesis and enterohepatic circulation ; Metabolic pathway of LDL, HDL and TG, including diseases; Orexin receptor pathway; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5; DNA damage response (only ATM dependent)",0.65,0.622,0.641,0.713,0.67,90.8,86.9,89.5,139.7,99.6,93.5,88.7,91,94.5,87.1,83.7,90.1,89.6,89.7,90.4,140,161.2,116.9,96.2,99.8,100.9,94.5,92,93.7,2206.8,2264,2350.7,2166.7,2082,2242.6,2228.1,2230.4,2250,3481.6,4009.7,2908,2392.9,2483.1,2508.9,2350.8,2289.4,2331.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["B9A064-1","Immunoglobulin lambda-like polypeptide 5 [OS=Homo sapiens]",48,8,196,8,214,23,8.84,691.91,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","IGLL5","ENSG00000254709","","","",0.65,0.644,0.69,0.717,0.704,88.6,87.8,93.9,136.2,97.6,95.8,91.3,85.8,85.5,85,94.3,84.2,98.9,91,89.8,131.9,118.2,165.7,94.2,103,94.5,92.5,92.8,101.7,29313.6,27552,27448.9,27301.6,30276.3,27030.7,31765.9,29219.2,28836.7,42363.8,37975.4,53210.2,30251.1,33072.5,30366,29721.6,29804.1,32650.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6UW56","All-trans retinoic acid-induced differentiation factor [OS=Homo sapiens]",7,2,3,2,229,24.7,7.25,4.56,"other biological processes","plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component","","ATRAID","ENSG00000138085","","","",0.651,0.672,0.68,0.7,0.728,88.1,91,92,135.4,94.8,98.6,83.1,85.9,71.4,83.5,85.7,95,78.8,86.7,87.2,127.6,124.9,255.4,89.3,94.8,82.5,82.2,92.9,93,228.5,236.2,196.4,229.8,235.9,261.5,216.9,238.6,240,351,343.5,702.6,245.8,260.9,226.9,226.3,255.7,255.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q86V81","THO complex subunit 4 [OS=Homo sapiens]",23,5,18,5,257,26.9,11.15,71.33,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","ALYREF","","Nucleocytoplasmic transport; mRNA surveillance pathway; Spliceosome; Amyotrophic lateral sclerosis; Herpes simplex virus 1 infection","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript","",0.652,0.696,0.77,0.763,0.666,86,91.8,101.6,132,100.7,87.9,84.8,84.9,103.2,90.6,100.2,80,105.8,100.3,90.8,130.2,110.3,159,99.3,94.5,99.9,96.6,86.7,83.1,957.4,957.8,1164.7,1022.4,1131,902.9,1193.6,1131.6,1024.5,1469.8,1244.8,1794.7,1120.9,1067,1127,1089.9,978.9,937.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P15907","Beta-galactoside alpha-2,6-sialyltransferase 1 [OS=Homo sapiens]",26,8,16,8,406,46.6,9.01,46.93,"protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;other membranes;ER/Golgi","other molecular function","ST6GAL1","ENSG00000073849","N-Glycan biosynthesis; Other types of O-glycan biosynthesis; Metabolic pathways","Sialic acid metabolism; N-Glycan antennae elongation; Maturation of spike protein; Maturation of protein 3a; Maturation of protein 3a; Termination of O-glycan biosynthesis","Globo sphingolipid metabolism",0.652,0.668,0.669,0.692,0.674,89.8,92.1,92.2,137.8,95.3,92.8,90.4,90.9,90.9,93.8,91.6,93.2,93.3,93.6,93,139.4,144.2,114,96.4,97.1,95.8,94,93.3,95.1,1745.9,1756.6,1755.5,1811,1770.2,1800.4,1802.2,1808.4,1796.4,2693.3,2785.8,2201.6,1863,1874.7,1851,1815.1,1802,1836.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9P215","Pogo transposable element with KRAB domain [OS=Homo sapiens]",3,2,3,2,609,69.4,5.14,8.67,"other biological processes","nucleus","nucleic acid binding activity","POGK","ENSG00000143157","","","",0.652,0.678,0.675,0.75,0.617,89.5,93.1,92.6,137.2,102.9,84.6,68.5,67.2,52.9,71.3,68.4,69.9,78.6,69.5,61.6,103,78.3,596.5,65.5,77.2,82.3,55.3,63.5,70.6,107.7,105.7,83.2,112.2,107.6,109.9,123.7,109.3,96.9,162.1,123.1,938.5,103,121.5,129.4,86.9,100,111.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8ND04","Protein SMG8 [OS=Homo sapiens]",17,12,23,11,991,109.6,7.68,60.72,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol","","SMG8","ENSG00000167447","","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","",0.653,0.541,0.526,0.56,0.535,102.7,85.1,82.7,157.3,88,84.2,105.1,109.1,99.6,87.2,87.2,86.6,88,82.8,84.7,161,166.9,114.1,90.1,91.9,85.6,87.8,86.2,86,1717.6,1782.8,1627.8,1424.1,1424.6,1415.6,1437.9,1353.1,1383.5,2631,2727.3,1864.6,1472.1,1500.9,1398.8,1435.4,1408.5,1405.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P10276","retinoic acid receptor alpha [OS=Homo sapiens]",2,1,1,1,462,50.7,7.9,1.86,"protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function","RARA","ENSG00000131759","Th17 cell differentiation; Estrogen signaling pathway; Pathways in cancer; Transcriptional misregulation in cancer; Acute myeloid leukemia","Signaling by Retinoic Acid; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Nuclear Receptor transcription pathway; SUMOylation of intracellular receptors; Transcriptional regulation of granulopoiesis","Nuclear receptors; Adipogenesis; Nuclear receptors in lipid metabolism and toxicity; Wnt/beta-catenin signaling pathway in leukemia; White fat cell differentiation; Vitamins A and D - action mechanisms; Development of ureteric collection system; Orexin receptor pathway; Vitamin A and carotenoid metabolism",0.653,0.692,0.636,0.502,0.56,96.9,102.7,94.4,148.4,74.5,83.1,85.9,109.6,102.6,109,101.9,108.7,99.9,99.9,93.6,157.1,178.4,51.2,78.9,77.3,91.7,87.9,77.3,89.1,46.1,58.8,55.1,58.5,54.7,58.3,53.6,53.6,50.2,84.3,95.8,27.5,42.3,41.5,49.2,47.2,41.5,47.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q15910","Histone-lysine N-methyltransferase EZH2 [OS=Homo sapiens]",23,12,15,12,746,85.3,7.02,44.9,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","EZH2","ENSG00000106462","Lysine degradation; Metabolic pathways; MicroRNAs in cancer","HCMV Early Events; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Defective pyroptosis; Transcriptional Regulation by E2F6; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; PRC2 methylates histones and DNA","Cell differentiation - expanded index; Histone modifications; Endoderm differentiation; Interactome of polycomb repressive complex 2 (PRC2) ; MECP2 and associated Rett syndrome; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Malignant pleural mesothelioma",0.653,0.646,0.708,0.691,0.664,89.9,88.8,97.4,137.6,95,91.4,101.2,89.1,88.9,88.1,82.9,95.9,96.6,98.5,95.2,126.3,136.5,136.4,94.3,95.9,91.6,90.6,89.1,103.1,917.4,807.7,805.5,798.2,751.4,868.8,875.3,892.4,862.6,1144.4,1237.1,1236.5,854.2,869.4,830.5,821.1,807.2,934.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q7Z591","AT-hook-containing transcription factor [OS=Homo sapiens]",7,8,13,8,1439,155,6.32,43.93,"cell cycle OR cell proliferation;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity","AKNA","ENSG00000106948","","","",0.654,0.705,0.678,0.62,0.619,91.8,98.9,95.1,140.4,87,86.8,74.4,72.9,75.7,79.2,90.9,80.2,77.1,78.4,75.9,113.8,109,450.1,70.5,65.4,75.6,73,70.4,67.5,806.1,790.4,820.2,858,985.7,869.1,835.5,849.8,822.9,1233.2,1181.6,4878.2,764.4,708.5,818.9,791.7,762.8,731.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H0S4","Probable ATP-dependent RNA helicase DDX47 [OS=Homo sapiens]",20,9,18,9,455,50.6,9.1,45.01,"RNA metabolism OR transcription;other metabolic processes;signal transduction","nucleus","other molecular function","DDX47","ENSG00000213782","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",0.654,0.686,0.628,0.636,0.671,91.8,96.3,88.2,140.4,89.3,94.1,89,92.2,92.3,88.6,96.8,102.8,84.3,91.6,88.6,141.1,132.5,142.7,89.8,89.4,96.1,94.6,95.6,92.2,1542.6,1598.8,1599.1,1535.8,1677.9,1781.7,1461.3,1588.4,1535.8,2445.4,2296,2472.7,1556,1549.2,1665.7,1639.7,1656.3,1598.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P48736","Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [OS=Homo sapiens]",10,9,14,8,1102,126.4,7.5,42.78,"cell adhesion;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","PIK3CG","ENSG00000105851","Inositol phosphate metabolism; Metabolic pathways; cGMP-PKG signaling pathway; Chemokine signaling pathway; Phospholipase D signaling pathway; PI3K-Akt signaling pathway; Adrenergic signaling in cardiomyocytes; Apelin signaling pathway; Platelet activation; Cholinergic synapse; Oxytocin signaling pathway; Salmonella infection; Toxoplasmosis; Kaposi sarcoma-associated herpesvirus infection","Synthesis of PIPs at the plasma membrane; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); GPVI-mediated activation cascade; G beta:gamma signalling through PI3Kgamma","IL-5 signaling pathway; AMP-activated protein kinase (AMPK) signaling; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Prolactin signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; BDNF-TrkB signaling; Amplification and expansion of oncogenic pathways as metastatic traits; Physico-chemical features and toxicity-associated pathways; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Regulation of apoptosis by parathyroid hormone-related protein; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; Microglia pathogen phagocytosis pathway; PI3K-Akt signaling pathway; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Neural crest cell migration during development; Neural crest cell migration in cancer; Translation inhibitors in chronically activated PDGFRA cells; Head and neck squamous cell carcinoma; Osteoblast differentiation and related diseases; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Kisspeptin/kisspeptin receptor system in the ovary; Prostaglandin signaling; Regulation of actin cytoskeleton; EPO receptor signaling; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway",0.655,0.72,0.659,0.63,0.623,91.7,100.8,92.2,140,88.1,87.1,92.5,93.2,88.1,97.2,104.3,101.7,93,93.2,90.1,143.7,138.6,141.2,89,83.6,88.9,81.4,87.9,92.4,1182.7,1192.1,1125.9,1242.3,1333.2,1300.7,1189.5,1191,1151.4,1837.9,1771.8,1805.6,1137.4,1068.5,1137,1041.4,1124.2,1182,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O00566","U3 small nucleolar ribonucleoprotein protein Mpp10 [OS=Homo sapiens]",27,15,32,15,681,78.8,4.86,83.9,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","MPHOSPH10","ENSG00000124383","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",0.655,0.653,0.576,0.592,0.57,97.1,96.8,85.4,148.3,87.9,84.5,100.7,102.9,100,92.3,100.4,101,88.5,91.9,87.8,159.4,153.8,88.1,92.8,84.1,91.1,87.6,91.1,86.5,2424.3,2477.5,2406.6,2221.4,2415.2,2430,2130.9,2211.7,2113.7,3835.5,3701,2119.3,2232.5,2023.4,2192.4,2108.6,2192.1,2082.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NUN5-1","Probable lysosomal cobalamin transporter [OS=Homo sapiens]",3,1,5,1,540,61.3,7.77,26.22,"other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;other molecular function","LMBRD1","ENSG00000168216","Vitamin digestion and absorption","Cobalamin (Cbl, vitamin B12) transport and metabolism; Defective ABCD4 causes MAHCJ","",0.656,0.715,0.697,0.75,0.748,86.2,94,91.6,131.4,98.6,98.2,85.9,88.1,89.1,97.1,91.6,96.1,93.6,90.9,97.4,134.3,135.3,101.1,104.4,100.8,98,100.9,94.9,100.4,428.6,439.5,444.5,484.6,457.1,479.5,467.1,453.6,486.2,670.2,675.2,504.3,520.9,503,488.8,503.4,473.5,501.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P16144-1","Integrin beta-4 [OS=Homo sapiens]",1,1,1,1,1822,202,6.09,4.93,"cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","extracellular matrix;plasma membrane;other membranes;nucleus;other cell component","signal transduction activity or receptor binding","ITGB4","ENSG00000132470","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Regulation of actin cytoskeleton; Human papillomavirus infection; Hypertrophic cardiomyopathy; Arrhythmogenic right ventricular cardiomyopathy; Dilated cardiomyopathy","Assembly of collagen fibrils and other multimeric structures; Syndecan interactions; Laminin interactions; Type I hemidesmosome assembly","Integrin-mediated cell adhesion; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Alpha 6 beta 4 signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; TGF-beta signaling pathway; Regulation of apoptosis by parathyroid hormone-related protein; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Netrin-UNC5B signaling pathway; Nephrotic syndrome; Malignant pleural mesothelioma; Congenital generalized lipodystrophy (CGL)",0.656,0.735,0.805,0.798,0.766,82.7,92.6,101.5,126,100.6,96.6,81.8,80.3,92.1,88.5,91.6,97.9,100.4,92.8,109.7,105.1,124.6,144.7,95.2,99.5,108.6,94.9,95.5,96.9,97,95.3,109.3,105,108.7,116.2,119.1,110.1,130.2,124.7,147.9,171.7,113,118.1,128.9,112.6,113.4,114.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8IYW5","E3 ubiquitin-protein ligase RNF168 [OS=Homo sapiens]",8,3,3,3,571,65,7.96,10.46,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","RNF168","ENSG00000163961","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Nonhomologous End-Joining (NHEJ); Processing of DNA double-strand break ends; SUMOylation of DNA damage response and repair proteins; G2/M DNA damage checkpoint","ATM signaling in development and disease ; 3q29 copy number variation syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome",0.656,0.536,0.555,0.595,0.575,100.5,82.1,85,153.2,91.1,88.1,99.7,103.8,96.7,81.5,92.2,72.7,92.8,84.3,77,145.1,151.9,164.8,88.8,90.4,94.3,87,87.4,89.6,277.1,288.7,269,226.5,256.4,202.2,258.1,234.4,214.1,403.4,422.4,458.1,246.9,251.3,262.1,241.8,242.9,249.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P98170","E3 ubiquitin-protein ligase XIAP [OS=Homo sapiens]",12,5,7,5,497,56.6,6.65,12.2,"cell-cell signaling;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","XIAP","ENSG00000101966","Platinum drug resistance; NF-kappa B signaling pathway; Ubiquitin mediated proteolysis; Apoptosis; Apoptosis; Necroptosis; Focal adhesion; NOD-like receptor signaling pathway; Toxoplasmosis; Human T-cell leukemia virus 1 infection; Pathways in cancer; Chemical carcinogenesis; Small cell lung cancer","TNFR1-induced NFkappaB signaling pathway; Regulation of PTEN stability and activity; Deactivation of the beta-catenin transactivating complex; Regulation of necroptotic cell death; Regulation of TNFR1 signaling; Regulation of PTEN localization; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity","Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis modulation and signaling; Apoptosis; Focal adhesion; Copper homeostasis; NO/cGMP/PKG mediated neuroprotection; Complement system in neuronal development and plasticity",0.657,0.691,0.676,0.66,0.69,90.2,94.8,92.7,137.2,90.5,94.6,93.4,93.7,92.9,98.2,95.4,103.9,96.3,93.2,96,149.3,142.1,79.9,93.8,93.8,88.4,98,93.2,98.5,581.1,583,577.7,611.1,593.3,646.5,599.3,580.1,597.4,928.7,884.1,497.3,583.7,583.5,549.7,609.8,579.8,612.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P26358-1","DNA (cytosine-5)-methyltransferase 1 [OS=Homo sapiens]",36,45,110,1,1616,183.1,7.75,300.92,"cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DNMT1","ENSG00000130816","Cysteine and methionine metabolism; Metabolic pathways; MicroRNAs in cancer","NoRC negatively regulates rRNA expression; PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; SUMOylation of DNA methylation proteins","Trans-sulfuration pathway; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration and one-carbon metabolism; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; MTHFR deficiency",0.658,0.64,0.608,0.625,0.647,94.4,91.9,87.3,143.6,89.8,93,95.9,100.4,99.3,96.7,83.2,96.6,91.8,97.2,84.1,151,169.6,65.5,97.7,94.5,90.9,97.8,98,89.7,395.4,413.6,409.3,398.5,342.9,398.2,378.3,400.6,346.7,622.5,699,270,402.7,389.3,374.5,403,403.7,369.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P55283","Cadherin-4 [OS=Homo sapiens]",1,1,1,1,916,100.2,4.82,2.21,"cell adhesion;cell organization and biogenesis;developmental processes","plasma membrane;other membranes","other molecular function","CDH4","ENSG00000179242","Cell adhesion molecules","Myogenesis; Adherens junctions interactions","Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Malignant pleural mesothelioma",0.658,0.679,0.796,0.712,0.773,85.5,88.2,103.4,129.9,92.5,100.5,97.2,80.1,83.7,86.4,103.4,84.8,101.2,100.4,105.9,103.4,127.2,167.8,93.9,87.2,90.6,98.4,85.4,103,70.4,58.1,60.6,62.6,75,61.4,73.4,72.8,76.7,74.9,92.2,121.6,68.1,63.2,65.6,71.3,61.9,74.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BXK1","krueppel-like factor 16 [OS=Homo sapiens]",19,3,3,2,252,25.4,9.88,8.02,"signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KLF16","ENSG00000129911","","","",0.658,0.682,0.71,0.707,0.712,88.3,91.6,95.3,134.3,94.9,95.6,84.1,83.7,87.7,91.7,83.2,87.2,95.5,90.7,90.8,108.7,127.9,214.7,87.5,103,90.4,91,94.2,88.1,100.7,100.3,105,109.8,99.6,104.5,114.3,108.6,108.8,130.2,153.2,257.1,104.8,123.3,108.3,109,112.8,105.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O76080","AN1-type zinc finger protein 5 [OS=Homo sapiens]",8,1,1,1,213,23.1,8.51,4.43,"developmental processes;signal transduction;other biological processes","other cell component","nucleic acid binding activity;other molecular function","ZFAND5","ENSG00000107372","","","",0.658,0.744,0.607,0.641,0.49,95.4,107.8,88,144.9,92.9,71,96.7,96.2,96.4,109,114.7,93,92.8,89,73.6,146.5,149.1,146.3,96.7,79.4,93.9,71.8,83.3,71.5,71.5,71.1,71.2,80.5,84.7,68.7,68.6,65.8,54.4,108.3,110.2,108.1,71.5,58.7,69.4,53.1,61.5,52.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NUD5","Zinc finger CCHC domain-containing protein 3 [OS=Homo sapiens]",12,5,6,5,404,43.6,8.53,15.41,"","","","","","","","",0.658,0.659,0.685,0.678,0.684,90.5,90.6,94.2,137.5,93.3,94.1,93.1,88.8,88,87.4,88.9,93.7,89.7,94.8,92.4,134.9,131.9,169.6,90.7,91.6,91.6,86.1,94.7,92.3,607.7,579.7,574.3,570.5,580.5,611.6,585.5,618.7,603.5,881.1,861,1107,592.3,597.7,598.3,562,618.2,602.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O43709-1","Probable 18S rRNA (guanine-N(7))-methyltransferase [OS=Homo sapiens]",16,3,9,3,281,31.9,8.73,35.36,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","BUD23","ENSG00000071462; ENSGGOG00000001453","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","7q11.23 copy number variation syndrome",0.658,0.654,0.63,0.676,0.678,92,91.3,88,139.7,94.4,94.7,90.2,94.5,92,91.3,91.6,88.7,87.4,88,91.9,139.7,137.8,140.6,94.4,92.8,94.6,97.8,92.1,94.7,720.7,755.3,734.9,729.6,732,708.6,698.2,703.2,734.8,1116.2,1101.8,1123.9,754.9,741.6,755.7,782,736.5,756.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BVP2","Guanine nucleotide-binding protein-like 3 [OS=Homo sapiens]",25,11,36,11,549,62,9.16,97.22,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","GNL3","ENSG00000163938","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol","",0.659,0.674,0.603,0.624,0.591,95.2,97.4,87.2,144.6,90.2,85.4,99.2,95,95.4,97.6,98.3,95.7,90.1,87.4,87.1,155.8,144.8,126.9,90.5,88.5,90.3,85.6,84.3,87.5,2866.4,2746.9,2757.4,2819.6,2842.5,2766.1,2605.6,2525.5,2517.1,4503.1,4186.4,3666.6,2616,2557,2611.1,2474.3,2435.5,2527.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H0M0-1","NEDD4-like E3 ubiquitin-protein ligase WWP1 [OS=Homo sapiens]",5,4,10,1,922,105.1,5.9,19.16,"protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","WWP1","ENSG00000123124","Ubiquitin mediated proteolysis; Endocytosis","Antigen processing: Ubiquitination & Proteasome degradation; Regulation of RUNX2 expression and activity; Stimuli-sensing channels; Downregulation of ERBB4 signaling","TGF-beta signaling pathway",0.659,0.824,0.734,0.69,0.729,85.3,106.6,95,129.4,89.3,94.4,98.5,84.5,84,99.4,115.8,105.7,94.1,94.1,99.1,128.2,97.9,150.4,95.3,87.1,88.4,102.6,81.2,93.5,111.2,95.4,94.8,112.3,130.7,119.3,106.3,106.2,111.9,144.8,110.6,169.8,107.6,98.3,99.8,115.8,91.7,105.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q969R5-1","Lethal(3)malignant brain tumor-like protein 2 [OS=Homo sapiens]",2,1,1,1,705,79.1,6.84,4.57,"cell organization and biogenesis;other biological processes","nucleus","other molecular function","L3MBTL2","ENSG00000100395","","SUMOylation of chromatin organization proteins; Transcriptional Regulation by E2F6","",0.659,0.674,0.658,0.637,0.665,92.1,94.2,92,139.8,89,93,85.1,73.9,88.6,93.6,87,76.1,94.7,84.9,82.7,129.1,124.2,275.7,82.2,81.3,82.8,87.5,85.9,84.9,89.1,77.4,92.7,98,91.1,79.8,99.1,89,86.6,135.2,130.1,288.8,86,85.1,86.7,91.7,90,89,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UL63-1","muskelin [OS=Homo sapiens]",3,2,2,2,735,84.7,6.34,5.56,"cell adhesion;cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","MKLN1","ENSG00000128585","","","Ciliary landscape",0.659,0.686,0.689,0.739,0.642,89.6,93.2,93.7,135.9,100.4,87.3,87.3,100.4,86.9,104.8,84,90.8,88,93.3,91.3,109.3,132.4,184.8,97.8,102,91.8,87.6,85,82.5,159.4,183.3,158.7,191.4,153.4,165.8,160.6,170.4,166.7,199.5,241.8,337.4,178.6,186.2,167.6,159.9,155.2,150.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NTW7","Zinc finger protein 64 homolog, isoforms 3 and 4 [OS=Homo sapiens]",5,3,3,3,645,72.2,8.43,9.73,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZFP64","ENSG00000020256","","","",0.66,0.697,0.775,0.715,0.741,86.4,91.1,101.3,130.8,93.5,97,80.6,84.5,84.4,89,103.4,88.1,105.2,99,86.4,127.8,117.3,175.7,88.6,99.7,91.3,85.1,94.7,99.2,164.9,173,172.7,182.2,211.5,180.2,215.3,202.5,176.9,261.4,240,359.5,181.3,204,186.9,174.2,193.8,203,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O43663-1","Protein regulator of cytokinesis 1 [OS=Homo sapiens]",25,12,17,12,620,71.6,6.68,47.23,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","PRC1","ENSG00000198901","","RHO GTPases activate CIT","",0.66,0.79,0.681,0.717,0.745,86.3,103.2,88.9,130.6,93.7,97.3,93,86.9,86.5,91,108.9,104,89.1,89.6,94,140.3,107.2,131.6,94.4,90,98.6,97.3,98.1,99.8,1146.4,1071.7,1066.4,1122.7,1342.3,1282.4,1098.3,1105.2,1158.7,1730.3,1321.3,1622.7,1163.6,1109.4,1215.6,1199.2,1209.4,1230.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H9L3","Interferon-stimulated 20 kDa exonuclease-like 2 [OS=Homo sapiens]",13,4,5,4,353,39.1,9.94,12.94,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","ISG20L2","ENSG00000143319","","Major pathway of rRNA processing in the nucleolus and cytosol","",0.662,0.608,0.693,0.659,0.627,93.5,85.8,97.8,141.3,93,88.5,92,93.3,93.9,90.6,85.6,81,97.6,98.4,85.6,126,140.9,171.2,82.8,104,92.8,76.3,88.3,99.7,228.5,231.8,233.4,225,212.8,201.1,242.5,244.4,212.7,313.1,350.2,425.3,205.8,258.4,230.6,189.7,219.5,247.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q969G3","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 [OS=Homo sapiens]",36,16,44,15,411,46.6,4.88,129.97,"cell organization and biogenesis;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","SMARCE1","ENSG00000073584","Thermogenesis; Hepatocellular carcinoma","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines","Androgen receptor signaling pathway; Pathways affected in adenoid cystic carcinoma; Tumor suppressor activity of SMARCB1; Thermogenesis",0.663,0.761,0.844,0.855,0.813,80.6,92.5,102.6,121.6,104,98.8,78.8,78.5,120.9,104.3,90.4,87.7,100.3,104.5,90.7,134.2,110,118.8,113.5,88.8,101.6,112.6,96.6,67.9,2508.8,2500.8,3848.6,3321,2880.1,2792,3192.6,3326.7,2889.6,4272.6,3503.5,3784.5,3614.6,2827.1,3236.1,3586.3,3076.3,2161.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6UUV7-1","CREB-regulated transcription coactivator 3 [OS=Homo sapiens]",1,1,1,1,619,66.9,6.84,0,"cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","other molecular function","CRTC3","ENSG00000140577","Human T-cell leukemia virus 1 infection","Circadian Clock; Heme signaling; Transcriptional activation of mitochondrial biogenesis","",0.663,0.687,0.743,0.633,0.648,91,94.2,101.9,137.2,86.8,88.9,80.2,79.2,81,96.7,82.5,83,89.8,94.5,85.6,111.6,120.9,320.6,89.2,76.5,75.8,78.4,85.8,68.7,55.2,54.5,55.8,66.6,56.8,57.2,61.8,65.1,58.9,76.9,83.3,220.8,61.4,52.7,52.2,54,59.1,47.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y5Y5","Peroxisomal membrane protein PEX16 [OS=Homo sapiens]",15,3,8,3,336,38.6,9.85,31.89,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","other molecular function","PEX16","ENSG00000121680","Peroxisome","Class I peroxisomal membrane protein import","",0.663,0.637,0.673,0.644,0.63,93.7,90,95,141.3,91,89,101.5,86.4,89.9,82.1,109.1,86.3,102.8,91.2,89.5,135.5,88.8,187.6,86.6,99.5,87.3,85.1,85.3,105.6,678.1,577.1,600.6,548.5,729,576.8,687.1,609.2,598.2,905.4,593.5,1253.7,579,664.6,583.4,568.8,570.3,706,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q11201","CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 [OS=Homo sapiens]",15,4,7,4,340,39.1,9.09,28.5,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","ST3GAL1","ENSG00000008513","Mucin type O-glycan biosynthesis; Glycosaminoglycan biosynthesis; Glycosphingolipid biosynthesis; Glycosphingolipid biosynthesis; Metabolic pathways","Maturation of spike protein; Sialic acid metabolism; Keratan sulfate biosynthesis; Maturation of protein 3a; Maturation of protein 3a; Termination of O-glycan biosynthesis","Ganglio sphingolipid metabolism; Globo sphingolipid metabolism",0.664,0.666,0.692,0.714,0.659,90.6,90.9,94.5,136.5,97.5,90,93.9,90.6,87.9,91.2,91,90.1,99.9,91.1,94.5,123.1,136.5,145,93.3,103.1,97.5,90,86.6,94.8,579.3,559,542.2,562.9,561.4,555.9,616.7,561.9,583.1,760,842.4,894.8,575.5,636.4,601.9,555.6,534.4,585,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6PKC3-1","Thioredoxin domain-containing protein 11 [OS=Homo sapiens]",16,13,30,13,985,110.5,6.55,71.03,"","other membranes;ER/Golgi","","TXNDC11","ENSG00000153066","","","",0.664,0.682,0.686,0.67,0.685,90.8,93.3,93.8,136.7,91.7,93.7,91.4,91,91,93.4,93.1,97.4,94,95.8,93.3,139.8,137,124.4,91.8,89.5,96.4,93.9,92.6,94.4,2385,2374.4,2374.3,2438.7,2429.7,2540.9,2452.8,2499.2,2434.5,3648.2,3574.9,3246.4,2396.8,2336.2,2514.9,2450,2416.3,2462.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q14444-1","Caprin-1 [OS=Homo sapiens]",22,11,39,11,709,78.3,5.25,111.86,"developmental processes;other biological processes","cytosol;other cell component","nucleic acid binding activity","CAPRIN1","ENSCATG00000038427; ENSG00000135387; ENSMMUG00000021643; ENSMNEG00000030485; ENSRROG00000039325","","","",0.664,0.62,0.61,0.59,0.639,96.7,90.2,88.8,145.5,85.8,93,97.6,98.8,101.5,92.1,88.8,95.2,96.1,90.7,90.7,148.7,150.5,106.1,97.7,82.9,87.6,95,96.2,83.8,4400.8,4455.2,4578,4154.9,4007.5,4293.4,4333.6,4093.7,4092.9,6706.8,6789.1,4787.1,4408.4,3737.9,3953.9,4287.6,4339,3781.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NXW2-1","DnaJ homolog subfamily B member 12 [OS=Homo sapiens]",21,7,9,7,375,41.8,8.53,25.12,"","","","","","","","",0.664,0.614,0.628,0.691,0.647,93.9,86.8,88.8,141.4,97.7,91.5,93.8,89.8,97.1,86.7,87.3,83.4,89.3,88.7,86.7,132.5,141.2,158.8,97.6,101,95.1,92,87.5,91.4,966.6,925.6,1000.4,893.6,899.8,859.6,920.7,913.6,893.8,1365.4,1455,1636.7,1005.3,1040.9,980.2,948.5,901.5,941.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8NBM4-1","Ubiquitin-associated domain-containing protein 2 [OS=Homo sapiens]",5,2,4,2,344,38.9,9.01,5.91,"cell-cell signaling;signal transduction;other biological processes","other membranes;ER/Golgi","","PHGDHL1; UBAC2","ENSG00000134882; ENSPTRG00000005994","","","",0.665,0.738,0.689,0.739,0.685,88.3,98.1,91.6,132.8,98.2,91,80.5,85.7,83.9,93.2,89.3,96.6,95.6,87,83.9,111.3,126.3,214.6,86.7,98.9,93.3,86.5,85.4,101.2,227.9,242.7,237.6,263.8,252.8,273.4,270.6,246.3,237.5,315.1,357.5,607.5,245.6,279.9,264.2,245,241.8,286.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P32519-1","ETS-related transcription factor Elf-1 [OS=Homo sapiens]",8,4,7,4,619,67.5,5.21,25.82,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ELF1","ENSG00000120690; ENSGGOG00000010760","","RUNX1 regulates transcription of genes involved in interleukin signaling; RUNX1 regulates transcription of genes involved in BCR signaling","",0.665,0.758,0.671,0.647,0.656,90.8,103.4,91.6,136.4,88.3,89.5,86.7,98.2,89.7,105,102.2,100.9,89,94,90.5,123.7,134.9,160.7,84,87.3,91.1,88.5,89.3,84.2,587.8,665.5,608.1,711.3,692.7,683.9,602.9,637.4,613.5,838.1,914,1089,569.6,591.5,617.7,600,605.3,570.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P83916","Chromobox protein homolog 1 [OS=Homo sapiens]",69,10,36,9,185,21.4,4.93,83.5,"stress response;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","CBX1","ENSG00000108468","","HCMV Early Events","Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome",0.665,0.749,0.988,0.962,0.793,77.4,87.1,115,116.3,111.9,92.3,75.2,71.2,116.9,99.5,84.7,84.1,111.8,115.2,98,113.1,91.5,133.9,114.4,98.6,108.7,117.6,89.7,75.9,1734.9,1642.3,2696,2293.1,1953.2,1940.2,2577.2,2656.4,2260.5,2607.2,2110.2,3086.8,2637.5,2273.1,2507.4,2711.6,2067.6,1749.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H0G5","Nuclear speckle splicing regulatory protein 1 [OS=Homo sapiens]",29,15,20,15,558,66.4,8.84,43.74,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","NSRP1","ENSG00000126653","","","",0.666,0.674,0.647,0.667,0.648,92.8,94.1,90.2,139.5,93,90.4,92.6,97,93.1,89.9,98.9,94.4,93,90.5,87.9,140,142.5,122.2,93.1,93.3,98.8,90,92,90.7,1920.3,2010.2,1931.1,1864.5,2051.2,1956.3,1928.9,1876.7,1821.9,2901.4,2955.2,2533.1,1931,1933.9,2047.6,1865.5,1907.8,1880.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q13588","GRB2-related adapter protein [OS=Homo sapiens]",3,1,4,1,217,25.3,7.03,6.65,"cell-cell signaling;signal transduction;other biological processes","other membranes;cytosol;other cell component","","GRAP","ENSG00000154016","","Signaling by SCF-KIT","",0.666,0.63,0.618,0.678,0.717,92.7,87.7,86.1,139.2,94.4,99.8,97.8,97.4,96.5,92.2,83.2,93.3,87.7,90.5,102.7,146.4,148.3,56.7,101.1,95.6,99.3,104.9,100.4,106.1,475.1,473.2,468.4,447.7,404.1,452.9,425.9,439.5,498.5,710.7,720.3,275.3,490.7,464.3,482.1,509.5,487.4,515.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O60870","DNA/RNA-binding protein KIN17 [OS=Homo sapiens]",13,5,13,5,393,45.3,8.95,36.4,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response","nucleus;other cell component","nucleic acid binding activity;other molecular function","KIN","ENSG00000151657","","Protein methylation","",0.666,0.698,0.678,0.69,0.67,90.8,95.2,92.4,136.3,94.1,91.3,89.9,90.9,89.3,94.2,98,91.9,91.4,89.3,92.1,134.9,130.7,145,91.8,100.5,93.1,88.6,98,90.4,686.6,694.4,682.6,719.9,748.9,701.9,698.7,682.4,704,1031.1,998.5,1108,701.6,767.9,711.5,677,748.5,690.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y3X0","coiled-coil domain-containing protein 9 [OS=Homo sapiens]",17,9,13,9,531,59.7,5.4,33.02,"","","","CCDC9","ENSG00000105321","","","IL-18 signaling pathway",0.666,0.83,0.893,0.891,0.744,79.5,99.2,106.6,119.4,106.4,88.9,79.3,72.8,116.2,109.6,98.8,81.9,106.2,113,98,142.5,119,67.1,109.4,106,103.3,109,88.6,79.3,2041.7,1874.8,2994.2,2822.8,2546.1,2109.6,2736.7,2912.1,2523.4,3671.6,3065.9,1727.5,2818.9,2731,2660.4,2808.8,2282.4,2042.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96JZ2","Hematopoietic SH2 domain-containing protein [OS=Homo sapiens]",22,7,10,7,352,39,7.11,23.95,"signal transduction","nucleus;other cell component","","HSH2D","ENSG00000196684","","","",0.666,0.697,0.647,0.667,0.641,92.6,96.8,89.9,139,92.7,89.1,87.3,88.2,92.6,88.3,102.3,92.3,88.4,85.6,82.3,132.4,128.4,212.1,88.3,86.9,88.7,83.5,84.8,87.7,652.5,658.9,692.2,659.5,764.2,689.4,660.4,639.8,614.8,989.5,960,1584.9,659.6,649.5,663.2,624,634.1,655.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O14561","Acyl carrier protein, mitochondrial [OS=Homo sapiens]",13,2,3,2,156,17.4,4.93,8.5,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;nucleus","other molecular function","NDUFAB1","ENSG00000004779","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Glyoxylate metabolism and glycine degradation; Mitochondrial Fatty Acid Beta-Oxidation; Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",0.666,0.699,0.604,0.644,0.558,95.8,100.6,86.8,143.9,92.7,80.2,90.4,95.4,92.7,97.6,77.8,97.3,84,87.2,82.9,92.6,139.2,232.9,89.7,98.2,82.7,77.6,104.8,77.1,231.6,244.5,237.6,250.3,199.4,249.5,215.3,223.5,212.4,237.4,356.7,597,229.8,251.8,212,198.9,268.7,197.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q15011-3","Isoform 3 of Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein [OS=Homo sapiens]",22,4,10,4,232,26.2,5.77,25.63,"","","","HERPUD1","","","","",0.666,0.613,0.604,0.577,0.538,100,92,90.6,150.1,86.6,80.7,96.7,95.8,96.7,89,94.5,84,91.6,87.7,87.5,145.1,139.5,207.1,83.7,85.6,81.1,73.5,78.1,82.9,825.8,817.7,825.6,760.1,806.7,717.1,782.5,748.5,747.6,1239.3,1190.9,1768.9,715,730.9,692.5,627.5,666.8,708,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6AI39","BRD4-interacting chromatin-remodeling complex-associated protein-like [OS=Homo sapiens]",2,2,2,2,1079,115,6.87,6.38,"other biological processes","nucleus","","BICRAL","ENSG00000112624","","","",0.667,0.735,0.761,0.75,0.735,86.1,94.9,98.2,129.1,96.9,94.8,86.2,80.4,102.8,81.7,110.2,95.1,98.4,99.4,81.1,129.3,124.6,133.4,97,93.4,102.3,92.4,95,97.3,106.8,99.6,127.3,101.2,136.5,117.8,121.8,123.1,100.5,160.2,154.3,165.2,120.2,115.6,126.8,114.4,117.7,120.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y3B9","RRP15-like protein [OS=Homo sapiens]",16,5,12,5,282,31.5,5.52,20.14,"RNA metabolism OR transcription;other metabolic processes","other cell component","","RRP15","ENSG00000067533","","","",0.667,0.631,0.649,0.667,0.666,93.5,88.4,90.9,140.2,93.6,93.3,96.1,95.6,101.1,96.2,90.8,88.6,93.4,93.9,89.9,144,147.8,98.5,98.3,96.1,86.6,95.9,99.7,87.4,1823.2,1814.6,1919.7,1826,1724.2,1682,1772.7,1781.4,1706.5,2733.3,2804.3,1870,1865.9,1823.8,1643.9,1819.8,1891.5,1659.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H237","Protein-serine O-palmitoleoyltransferase porcupine [OS=Homo sapiens]",2,1,1,1,461,52.3,8.84,2.49,"cell-cell signaling;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","PORCN","ENSG00000102312","Wnt signaling pathway","WNT ligand biogenesis and trafficking; LGK974 inhibits PORCN","lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Malignant pleural mesothelioma",0.669,0.913,0.788,1.174,0.715,76.3,104.2,89.9,114.1,134,81.6,64.6,90.2,60.1,88.2,99.3,83.6,77.2,59.3,76.2,79,96.6,336.4,90.8,129.3,113.4,69.1,64.3,122.5,16.4,22.9,15.3,22.4,25.2,21.2,19.6,15,19.3,20,24.5,85.4,23,32.8,28.8,17.5,16.3,31.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["A8MW92","PHD finger protein 20-like protein 1 [OS=Homo sapiens]",1,1,1,1,1017,114.9,6.83,2.6,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","PHF20L1","ENSG00000129292","","","",0.669,0.701,0.655,0.591,0.656,93.9,98.4,92,140.5,83,92.2,91.9,83.6,105.3,89.7,98.7,96.4,89.5,114.2,90,137.5,138.5,114,81.2,78.1,105.7,90.2,108,87.4,51.8,47.1,59.3,50.5,55.6,54.3,50.4,64.3,50.7,77.4,78,64.2,45.7,44,59.5,50.8,60.8,49.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q14103-3","Isoform 3 of Heterogeneous nuclear ribonucleoprotein D0 [OS=Homo sapiens]",50,16,261,2,306,32.8,8.16,770.83,"","","","HNRNPD","","","","",0.669,0.645,0.676,0.73,0.691,91,87.7,92,136,99.3,94,112.5,87.4,84.2,83.6,84.8,84.2,107.6,88.3,84.8,134.2,122.2,130.6,94.7,118.4,95.3,90.3,85.1,111.9,1124.1,873.2,841.9,835,847.2,841.9,1075.7,882.5,847.7,1341.6,1221,1304.8,946.2,1183.7,952.6,902.1,850.5,1117.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q4LE39-1","AT-rich interactive domain-containing protein 4B [OS=Homo sapiens]",7,7,9,7,1312,147.7,5.12,28.62,"cell organization and biogenesis;other biological processes","cytosol;mitochondrion;nucleus","nucleic acid binding activity","ARID4B","ENSG00000054267","","Potential therapeutics for SARS; HDACs deacetylate histones; NoRC negatively regulates rRNA expression","Pathways affected in adenoid cystic carcinoma",0.67,0.708,0.662,0.647,0.648,92.8,97.9,91.6,138.4,89.6,89.7,92.3,89.1,94.9,97.2,99.5,97.4,91.1,92.8,88.4,144.6,137.6,128.8,89.1,88.4,95.6,87.4,89.3,96.6,654,631.6,672.5,688.8,705.3,690.6,646,657.7,626.4,1025.1,975.7,913,631.4,626.6,678,619.6,632.7,684.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H1J7","Protein Wnt-5b [OS=Homo sapiens]",4,2,4,2,359,40.3,8.4,10.49,"cell-cell signaling;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi","signal transduction activity or receptor binding","WNT5B","ENSG00000111186","mTOR signaling pathway; Wnt signaling pathway; Axon guidance; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Proteoglycans in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer","PCP/CE pathway; WNT ligand biogenesis and trafficking","Alzheimer's disease and miRNA effects; Adipogenesis; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Osteoblast differentiation and related diseases; Malignant pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)",0.67,0.814,0.738,0.687,0.664,88,106.8,96.8,131.2,90.2,87.1,88.9,80.4,87.7,114.1,106.2,106.5,100,94.7,96.5,134.8,123.6,130.9,89.9,95.5,89.6,91.1,82.8,86.9,440,398.1,434.1,564.8,525.4,526.8,494.8,468.5,477.6,667.2,611.5,647.5,444.9,472.3,443.2,450.7,409.6,429.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O60512","beta-1,4-galactosyltransferase 3 [OS=Homo sapiens]",22,6,13,6,393,43.9,9.25,41.19,"protein metabolism;other metabolic processes","other membranes;cytosol;ER/Golgi","other molecular function","B4GALT3","ENSG00000158850","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Other types of O-glycan biosynthesis; Mannose type O-glycan biosynthesis; Glycosaminoglycan biosynthesis; Glycosphingolipid biosynthesis; Metabolic pathways","N-Glycan antennae elongation; Keratan sulfate biosynthesis","",0.671,0.717,0.804,0.73,0.693,87.2,93.3,104.6,130,94.9,90.1,82.3,87.6,92.8,102.5,85.7,93.7,80.9,105.1,115.7,113.5,130.7,168.3,89.5,95.3,95.8,92.2,90.5,77.9,429.1,456.9,484.2,534.4,446.8,488.7,421.9,548.1,603.3,592,681.3,877.6,466.5,497.1,499.3,480.8,472.1,405.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q92547","DNA topoisomerase 2-binding protein 1 [OS=Homo sapiens]",4,3,5,3,1522,170.6,6.96,10.68,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","TOPBP1","ENSG00000163781","Homologous recombination","Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA)","ATR signaling",0.671,0.726,0.702,0.748,0.717,88.2,95.5,92.3,131.5,98.3,94.2,98.3,90.2,89.3,84.2,99.4,97.6,96.1,79.7,94.4,134.4,160,83,108.4,96.5,100.5,94.2,96.3,97.7,95.7,87.8,86.9,81.9,96.8,95,93.6,77.6,91.9,130.8,155.7,80.7,105.5,93.9,97.8,91.7,93.8,95.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O15294","UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit [OS=Homo sapiens]",12,12,22,12,1046,116.9,6.7,62.76,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component","other molecular function","OGT","ENSG00000147162","Other types of O-glycan biosynthesis; Insulin resistance","UCH proteinases; Regulation of necroptotic cell death; HATs acetylate histones","Ectoderm differentiation; Ectoderm differentiation",0.671,0.693,0.689,0.706,0.704,90.2,93.2,92.7,134.4,94.9,94.7,88.8,87.8,88.4,88.9,91.4,93.4,90.8,91.5,89.1,131.7,126.2,174.8,90.7,93.6,93,92.7,92.8,94.6,2483.2,2455.5,2473.1,2486.3,2556,2612.7,2541,2559.2,2492.5,3685.8,3531.2,4889.2,2536.3,2619.6,2601.2,2593,2596.2,2647.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8WWM7-1","ataxin-2-like protein [OS=Homo sapiens]",32,28,81,27,1075,113.3,8.59,230.61,"cell organization and biogenesis;other biological processes","other membranes;cytosol;nucleus;other cell component","","ATXN2L","ENSG00000168488","Amyotrophic lateral sclerosis; Spinocerebellar ataxia; Pathways of neurodegeneration","","16p11.2 distal deletion syndrome",0.671,0.678,0.664,0.659,0.665,92.8,93.9,91.8,138.3,91.2,92,90.8,92.4,99.2,93.4,92.8,99.4,95.1,91.4,90.4,137.7,131.2,149.6,94.3,82.7,90.8,93.9,91.6,83.3,9517.7,9688.1,10398.5,9794.3,9733.1,10415.1,9966.1,9580.3,9476.4,14436.5,13757.8,15680.9,9887.4,8672.5,9513.6,9843.3,9597.3,8734,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P47974","mRNA decay activator protein ZFP36L2 [OS=Homo sapiens]",3,2,2,1,494,51,8.16,4.65,"RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZFP36L2","ENSG00000152518","Cellular senescence","","Pre-implantation embryo; TYROBP causal network in microglia",0.671,0.864,0.705,0.669,0.644,88.4,113.8,92.9,131.8,88.2,84.9,109.3,81.3,87.1,112.1,115.9,107.2,81.7,99.5,91.4,129.8,131.7,126.5,95.2,86.8,84.7,83.6,82.7,93.5,85.7,63.8,68.3,87.9,90.9,84.1,64.1,78,71.7,101.8,103.3,99.3,74.7,68.1,66.4,65.6,64.9,73.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NRF9","DNA polymerase epsilon subunit 3 [OS=Homo sapiens]",28,5,8,5,147,16.8,4.74,26.03,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response","nucleus","nucleic acid binding activity;other molecular function","POLE3","ENSG00000148229","DNA replication; Base excision repair; Nucleotide excision repair","Activation of the pre-replicative complex; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Gap-filling DNA repair synthesis and ligation in GG-NER; PCNA-Dependent Long Patch Base Excision Repair; DNA replication initiation","Pyrimidine metabolism; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair",0.672,0.541,0.654,0.649,0.778,93.9,75.6,91.4,139.8,90.6,108.7,91,96.1,104.7,77.3,74.2,93.6,108,91.2,93.5,143,147,73.3,108.8,82.3,92.8,111.3,127.9,84.2,1048.4,1106.9,1206.1,890.6,854.5,1078,1244.8,1050.2,1077.3,1647.5,1693.3,844.1,1253.1,948,1068.6,1281.9,1473.7,970,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UNS1","Protein timeless homolog [OS=Homo sapiens]",7,6,12,6,1208,138.6,5.4,27.19,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity","TIMELESS","ENSG00000111602","","Processing of DNA double-strand break ends","",0.672,0.679,0.709,0.769,0.725,88.5,89.4,93.4,131.8,101.4,95.6,87,78.8,87.3,87.9,88.8,81.7,91.8,83.1,93.2,129.5,126.9,182.1,99.5,99.7,100.9,90.9,97,93.9,352.2,319.1,353.2,355.7,359.5,330.6,371.4,336.2,377,524.2,513.7,737.1,402.7,403.3,408.4,367.8,392.5,380.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q2YD98-1","UV-stimulated scaffold protein A [OS=Homo sapiens]",5,3,4,3,709,80.5,6.3,11.75,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","other molecular function","UVSSA","ENSG00000163945","","Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER","Nucleotide excision repair in xeroderma pigmentosum",0.672,0.708,0.693,0.674,0.676,91.2,96,94,135.7,91.5,91.7,89,95.6,84,101.8,93.7,87.8,96.8,86.1,91.7,122.3,132.4,168.1,88.1,89.2,96.2,106,81.9,89.5,161.7,173.7,152.6,185.1,170.2,159.6,175.9,156.6,166.7,222.3,240.6,305.4,160.1,162.2,174.8,192.6,148.8,162.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q7Z4F1","Low-density lipoprotein receptor-related protein 10 [OS=Homo sapiens]",1,1,1,1,713,76.1,5.52,0,"other metabolic processes;transport;developmental processes","plasma membrane;other membranes","other molecular function","LRP10","ENSG00000197324","","Retinoid metabolism and transport","",0.672,0.776,0.664,0.704,0.642,90.5,104.4,89.4,134.6,94.8,86.4,78.5,64.7,80.2,90.6,73.4,93.5,86,69.9,77.5,82.3,116.8,403.1,81.8,82.2,94.5,74.9,82,67.8,54,44.5,55.1,62.3,50.5,64.3,59.1,48.1,53.3,56.6,80.3,277.1,56.2,56.5,64.9,51.5,56.3,46.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q5T5P2-1","Sickle tail protein homolog [OS=Homo sapiens]",8,16,17,15,1943,214,7.06,29.96,"developmental processes;other biological processes","other cell component","enzyme regulator activity","KIAA1217","ENSG00000120549","","","",0.672,0.751,0.706,0.712,0.684,89.1,99.5,93.6,132.6,94.4,90.7,92.1,87.5,87.3,97.7,104.8,96.1,97.8,91.8,91.9,130.2,118.9,156.8,89.2,93.6,92.7,89,88.9,93.6,1406.9,1336.7,1332.4,1492.6,1600.3,1466.8,1493.3,1402.1,1403.7,1988,1816,2395,1362.3,1429,1415.7,1359.5,1356.9,1428.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8IY37","Probable ATP-dependent RNA helicase DHX37 [OS=Homo sapiens]",8,7,10,7,1157,129.5,8.1,28.18,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","other membranes;nucleus;other cell component","nucleic acid binding activity;other molecular function","DHX37","ENSG00000150990","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",0.673,0.717,0.662,0.682,0.686,91.3,97.4,89.9,135.8,92.5,93.1,86.3,83.1,85.8,86.8,93.8,91.4,84.4,85.7,80.1,127.5,120.1,262.5,88.3,82.6,86.9,78.5,88.6,87.4,630.5,607.3,626.4,634,685.3,668,616.7,625.9,585.3,931.3,877.7,1917.9,645.2,603.6,634.7,573.7,647,638.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q5THK1-1","Protein PRR14L [OS=Homo sapiens]",2,2,2,2,2151,237.2,6.33,8.2,"","","","PRR14L","ENSG00000183530","","","",0.673,0.753,0.714,0.643,0.566,92.9,103.8,98.5,138,88.7,78.1,81.5,106.6,87.9,96.1,101.2,98.3,93,93.2,114.7,119.2,130.5,198,75.3,105.7,84,73.9,63.8,77.3,44.2,57.7,47.6,52,54.8,53.2,50.4,50.5,62.1,64.6,70.7,107.2,40.8,57.2,45.5,40,34.5,41.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P59190-1","Ras-related protein Rab-15 [OS=Homo sapiens]",17,3,12,1,212,24.4,5.71,33.77,"transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","RAB15","ENSG00000139998","","RAB geranylgeranylation","",0.674,0.898,1.026,0.842,0.872,76.1,101.5,115.9,112.9,95.1,98.5,68.9,107.5,71.8,95.7,112.6,92,109.9,92.3,109.4,79.5,106.6,175.9,89.7,70.9,111.8,92.9,86.7,126,21.4,33.4,22.3,29.7,35,28.6,34.1,28.7,34,24.7,33.1,54.7,27.9,22,34.7,28.9,26.9,39.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q13950-1","runt-related transcription factor 2 [OS=Homo sapiens]",16,6,11,2,521,56.6,8.85,39.35,"developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RUNX2","ENSG00000124813","Parathyroid hormone synthesis, secretion and action; Transcriptional misregulation in cancer","","Androgen receptor signaling pathway; Bone morphogenic protein (BMP) signaling and regulation; Cell differentiation - expanded index; Interleukin-11 signaling pathway; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Development of pulmonary dendritic cells and macrophage subsets; OSX and miRNAs in tooth development; Endochondral ossification; IL-18 signaling pathway; Osteoblast differentiation and related diseases; Endochondral ossification with skeletal dysplasias; TGF-beta receptor signaling in skeletal dysplasias; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Orexin receptor pathway; TGF-beta receptor signaling",0.674,0.711,0.673,0.697,0.692,91,95.9,90.8,134.9,94.1,93.4,89.1,89.8,92.5,94.7,96.1,93.2,94,86.7,89.6,124.9,133.3,158.3,92.9,96.9,92.9,89.4,93.5,92.2,991.9,1000.2,1029.3,1054.7,1069.6,1037.5,1046.1,965.5,998,1390.8,1483.4,1762,1034.2,1078.6,1034.3,995.6,1040.9,1026.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O43502","DNA repair protein RAD51 homolog 3 [OS=Homo sapiens]",2,1,1,1,376,42.2,6.74,2.89,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","RAD51C","ENSG00000108384","Homologous recombination; Fanconi anemia pathway","Resolution of D-loop Structures through Holliday Junction Intermediates; Factors involved in megakaryocyte development and platelet production; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Meiotic recombination","DNA repair pathways, full network",0.675,0.755,0.667,0.777,0.719,88.1,98.7,87.1,130.7,101.5,93.9,64.9,68.5,62,73.3,72.7,58.8,61,583.6,64.1,96.2,85.5,99.2,74.7,75.2,55.1,80.7,55.3,69.2,22.1,23.3,21.1,24.9,24.7,20,20.7,198.4,21.8,32.7,29.1,33.7,25.4,25.6,18.7,27.4,18.8,23.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9GZT5","Protein Wnt-10a [OS=Homo sapiens]",2,1,2,1,417,46.4,9.04,4.06,"cell-cell signaling;developmental processes;signal transduction;other biological processes","non-structural extracellular","signal transduction activity or receptor binding","WNT10A","ENSG00000135925","mTOR signaling pathway; Wnt signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Proteoglycans in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer","Class B/2 (Secretin family receptors); WNT ligand biogenesis and trafficking","Alzheimer's disease and miRNA effects; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Osteoblast differentiation and related diseases; Malignant pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)",0.675,0.876,0.795,0.718,0.757,84,109.1,98.9,124.5,89.4,94.2,84.7,81.3,88.9,109.9,112.1,95.3,113.5,95.7,99.7,125.5,121.4,128,90.1,90.3,85.3,97.7,85.8,94.9,240.7,231.1,252.5,312.4,318.5,270.8,322.5,271.9,283.4,356.6,344.9,363.7,256.1,256.7,242.5,277.6,243.7,269.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q92871","Phosphomannomutase 1 [OS=Homo sapiens]",11,3,3,2,262,29.7,5.74,6.52,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","other molecular function","PMM1","ENSG00000100417","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars","Synthesis of GDP-mannose","",0.675,0.753,0.723,0.697,0.663,89.8,100.2,96.1,133,92.7,88.1,87.3,92.1,90.6,97.9,101.1,106.5,106.2,93.2,97,134.3,140.6,103.4,93.9,93.6,89,89,98,86.3,220.9,233.2,229.5,247.9,256,269.7,268.8,235.9,245.6,339.9,355.9,261.8,237.8,237,225.2,225.2,248.2,218.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P02686-1","myelin basic protein [OS=Homo sapiens]",3,1,1,1,304,33.1,9.79,2,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","MBP","ENSG00000197971; ENSGGOG00000009590","","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Neural crest differentiation; Glial cell differentiation; Spinal cord injury; Interleukin-1 (IL-1) structural pathway; MECP2 and associated Rett syndrome; MAPK cascade; Complement system in neuronal development and plasticity",0.675,0.852,0.941,0.675,0.611,85.2,107.5,118.8,126.2,85.2,77.1,81,75,109.7,106,92.7,102.2,123.9,112.9,105.4,120,92.7,215,89.4,75.8,81,73.3,93,50.9,24.9,23.1,33.8,32.6,28.5,31.5,38.1,34.8,32.4,36.9,28.5,66.2,27.5,23.4,25,22.6,28.6,15.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O14530","Thioredoxin domain-containing protein 9 [OS=Homo sapiens]",33,6,14,6,226,26.5,5.88,40.52,"","cytosol;cytoskeleton;nucleus;other cell component","","TXNDC9","ENSG00000115514","","","",0.676,0.622,0.593,0.608,0.616,98.5,90.7,86.5,145.8,88.6,89.8,99.1,97.6,94.2,87.1,89.8,99.4,92.6,83.7,85.6,148.5,144.3,128.4,96.9,87.7,83.9,88.2,104,88.9,1247.2,1227.8,1185.3,1096.1,1130.5,1251,1165,1053.5,1077.6,1868.3,1816.3,1616,1218.9,1104.1,1055.5,1110.2,1308.7,1119.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P43355","Melanoma-associated antigen 1 [OS=Homo sapiens]",17,5,10,5,309,34.3,4.86,25.92,"other biological processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","MAGEA1","ENSG00000198681","","","Notch signaling pathway (Netpath)",0.676,0.67,0.647,0.636,0.62,95.4,94.6,91.4,141.2,89.8,87.6,98.7,91.3,95.5,94.7,102,94.7,96.5,91.5,88,152.6,141.3,115.2,89.9,93.4,86.9,86.3,87.7,93.8,641.2,592.9,620.6,615.1,662.8,614.9,626.8,594.3,571.5,991.3,918,748.5,583.9,606.9,564.8,560.7,569.4,609.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UHJ3-1","Scm-like with four MBT domains protein 1 [OS=Homo sapiens]",2,2,2,2,866,98.1,6.21,1.92,"cell organization and biogenesis;other biological processes","nucleus","other molecular function","SFMBT1","ENSG00000163935","","","",0.676,0.702,0.768,0.765,0.774,86.6,89.9,98.4,128.1,98,99.1,59.8,56.2,61.6,62.1,80.7,60.6,70.8,58.8,68,87.9,88.5,637.7,65.5,67.7,72.4,71,62.2,68.5,97,91.2,99.8,100.7,130.9,98.2,114.8,95.4,110.2,142.5,143.5,1034,106.2,109.7,117.4,115.2,100.9,111,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8N141","Zinc finger protein 82 homolog [OS=Homo sapiens]",1,1,1,1,532,62.5,8.98,2.89,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZFP82","ENSG00000181007","Herpes simplex virus 1 infection","","",0.676,0.676,0.73,0.699,0.659,91.4,91.3,98.7,135.1,94.4,89,103.8,96.5,87.3,92.5,106.8,96.3,85.5,104.3,104.1,150.1,142.6,47.7,90,99.7,104.2,93.9,91.4,103.3,153.1,142.3,128.8,136.5,157.6,142.1,126.1,153.9,153.7,221.5,210.4,70.4,132.8,147,153.7,138.6,134.9,152.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O43524","Forkhead box protein O3 [OS=Homo sapiens]",11,7,16,7,673,71.2,5.16,48.59,"RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","FOXO3","ENSG00000118689","EGFR tyrosine kinase inhibitor resistance; Chemokine signaling pathway; FoxO signaling pathway; Mitophagy; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Neurotrophin signaling pathway; Prolactin signaling pathway; Alcoholic liver disease; Shigellosis; Chemical carcinogenesis; Endometrial cancer; Non-small cell lung cancer","AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of localization of FOXO transcription factors; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; MAPK6/MAPK4 signaling; Signaling by NODAL; Interleukin-4 and Interleukin-13 signaling; FOXO-mediated transcription of cell cycle genes; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; RUNX3 regulates BCL2L11 (BIM) transcription; FLT3 Signaling; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation","IL-5 signaling pathway; Energy metabolism; Glioblastoma signaling pathways; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Kit receptor signaling pathway; Copper homeostasis; NAD metabolism, sirtuins and aging; Imatinib and chronic myeloid leukemia; Pathways affected in adenoid cystic carcinoma; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Non-small cell lung cancer; Overview of leukocyte-intrinsic Hippo pathway functions; Gastrin signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; DNA damage response (only ATM dependent)",0.677,0.664,0.643,0.572,0.531,99.3,97.5,94.4,146.8,84,77.9,101.9,98.1,98.7,97,99.5,94.9,94.6,93.9,89.2,139.7,145.9,157.3,83.5,85.1,83.1,82.6,77.5,77.4,1800.1,1734,1744.3,1713,1758.1,1677.1,1671,1658.7,1576.6,2468.2,2578.4,2778.4,1475.3,1502.7,1468.2,1460.2,1368.4,1368,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UET6","Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase [OS=Homo sapiens]",3,1,2,1,329,36.1,5.69,5.94,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;other cell component","other molecular function","FTSJ1","ENSG00000068438","","tRNA modification in the nucleus and cytosol","",0.677,0.682,0.694,0.75,0.73,89.6,90.3,91.8,132.4,99.3,96.7,90.5,86.4,86.2,83.1,93.4,87.1,104.5,87.3,88.6,119.7,127.7,198.9,95.8,98.5,84.6,81.2,93.2,93.4,136.1,129.9,129.6,124.9,140.4,131,157.2,131.3,133.2,179.9,192,299.1,144,148.1,127.2,122.2,140.2,140.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9GZM8-1","Nuclear distribution protein nudE-like 1 [OS=Homo sapiens]",13,4,4,2,345,38.4,5.24,10.32,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;transport;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","NDEL1","ENSANAG00000023019; ENSCANG00000000982; ENSCATG00000044729; ENSG00000166579; ENSGGOG00000013855; ENSMLEG00000034324; ENSMMUG00000021938; ENSPANG00000023797; ENSPTRG00000008744; ENSSBOG00000023939","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",0.677,0.695,0.641,0.566,0.607,97,99.6,91.9,143.3,81.2,87,91.8,112.6,90.2,82.5,94.2,111.8,73.7,104.1,87,133.2,135.6,188.9,91.1,73,76.8,79.1,92.1,82.3,103.2,126.6,101.4,92.8,105.9,125.6,82.8,117,97.8,149.7,152.5,212.3,102.4,82,86.3,89,103.5,92.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P54277","PMS1 protein homolog 1 [OS=Homo sapiens]",10,8,8,8,932,105.8,6.67,26.89,"DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","PMS1","ENSG00000064933","","","",0.677,0.672,0.665,0.713,0.713,91.5,90.8,89.9,135.1,96.3,96.4,90.6,90.6,97,90.1,86.7,89.9,89,88.1,89.3,117.6,133.8,168.2,95.4,93.6,95.7,98.4,95.5,90.6,675.5,675.5,722.9,671.6,646.5,670.3,663.5,657.1,665.7,876.8,997.9,1253.8,711,698.2,713.5,733.4,711.9,675.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8TDN6","Ribosome biogenesis protein BRX1 homolog [OS=Homo sapiens]",31,10,19,10,353,41.4,9.92,55.67,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","BRIX1","ENSG00000113460","","","Gastric cancer network 2",0.677,0.706,0.652,0.644,0.635,94.2,98.2,90.7,139,89.6,88.3,93.3,93.6,95.9,97.5,96.2,99.1,88.5,90.7,90.1,138.1,134.4,152.7,89,89,89.3,88,87,87.8,2511.5,2517.9,2580.6,2625.3,2588.9,2666.3,2380.5,2440,2424.2,3717.4,3616.3,4108.3,2394.2,2395.5,2402.2,2369.3,2341.6,2362,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96RU2-2","Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 28 [OS=Homo sapiens]",13,10,14,10,1045,119,5.16,50.14,"","","","USP28","","","","",0.677,0.71,0.711,0.711,0.698,90.2,94.5,94.7,133.1,94.7,92.9,87.2,90.4,88.4,92.6,97.1,87.5,95.4,91.7,92.8,128,130.5,164.1,95,92.8,92.1,89.1,91.1,94.3,1107.5,1147.6,1122,1175.3,1232.6,1111.2,1210.8,1164,1178.2,1624.2,1656.3,2083.1,1205.6,1177.7,1169.7,1131,1156,1196.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9ULT8","E3 ubiquitin-protein ligase hectd1 [OS=Homo sapiens]",7,15,18,15,2610,289.2,5.35,47.18,"protein metabolism;other metabolic processes;developmental processes;other biological processes","","other molecular function","HECTD1","ENSG00000092148","","Antigen processing: Ubiquitination & Proteasome degradation","",0.677,0.761,0.694,0.663,0.657,91.3,102.5,93.5,134.8,89.4,88.5,91.4,86.7,91,102.2,103.2,100,90.5,93.2,94.5,134.3,125.5,156.2,88.3,89.5,89.1,86.7,89.5,88.2,1386.8,1314.5,1379.9,1549.7,1565.1,1517.3,1372.4,1412.7,1433.7,2036.9,1903.1,2369.1,1339.5,1356.9,1351,1315.1,1357.3,1337.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96GQ7","Probable ATP-dependent RNA helicase DDX27 [OS=Homo sapiens]",25,19,37,19,796,89.8,9.28,93.02,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","other molecular function","DDX27","","","","",0.678,0.703,0.651,0.629,0.597,95.5,99.1,91.7,140.9,88.6,84.1,94,95.4,94.3,96.6,101.4,97.9,90.6,88,91.7,139.2,138.4,157.8,87.5,87.1,88.8,82.8,85.6,83.1,4176.7,4238,4190.7,4290.2,4505.9,4350.1,4025,3909.2,4072.8,6184.1,6147.7,7010.1,3887.3,3868.2,3944.6,3680.2,3804.1,3691.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H999","Pantothenate kinase 3 [OS=Homo sapiens]",13,4,9,2,370,41.1,6.55,21.39,"other metabolic processes","cytosol;nucleus","kinase activity;other molecular function","PANK3","ENSG00000120137","Pantothenate and CoA biosynthesis; Metabolic pathways; Biosynthesis of cofactors","Coenzyme A biosynthesis","",0.678,0.681,0.722,0.772,0.761,88.2,88.5,93.9,130.1,100.4,98.9,86.9,94.8,80.2,87.3,121.1,85.6,99.2,87.5,92.6,135.1,128.2,113.7,102.5,99,89.7,97.5,103,96.3,46.1,50.3,42.5,46.3,64.2,45.4,52.6,46.4,49.1,71.6,68,60.3,54.4,52.5,47.6,51.7,54.6,51.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BVS4","Serine/threonine-protein kinase rio2 [OS=Homo sapiens]",22,8,17,8,552,63.2,5.94,60.25,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","RIOK2","ENSG00000058729","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol","",0.678,0.706,0.693,0.657,0.634,93.2,96.9,95.2,137.4,90.3,87,90.7,93.6,93,101.8,96.8,96.8,95.9,95.1,90.3,135.9,137.1,143.7,90.2,91.6,86.2,86.9,85.4,88.9,803.9,829.4,824.3,902.5,857.5,857.5,849.5,842.4,800.3,1204,1215.2,1273.7,798.9,812.1,764.2,769.9,757,787.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q5T1R4-1","transcription factor HIVEP3 [OS=Homo sapiens]",0,1,1,1,2406,259.3,7.81,1.75,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HIVEP3","ENSG00000127124","","Regulation of RUNX2 expression and activity","",0.679,0.763,0.615,0.636,0.726,92.1,103.6,83.5,135.8,86.4,98.6,87.7,90.9,102.5,102.2,97,108.5,71.4,82.4,87.6,129.3,134,148.6,85.3,75.2,96.3,111.2,92.6,97.3,43.5,45,50.8,50.6,48.1,53.8,35.4,40.8,43.4,64.1,66.4,73.7,42.2,37.3,47.7,55.1,45.9,48.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P53805","Calcipressin-1 [OS=Homo sapiens]",8,1,3,1,252,28.1,5.21,6.33,"stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","RCAN1","ENSG00000159200","Thyroid hormone signaling pathway; Oxytocin signaling pathway; Kaposi sarcoma-associated herpesvirus infection","","MicroRNAs in cardiomyocyte hypertrophy; VEGFA-VEGFR2 signaling pathway",0.679,0.772,0.571,0.735,0.703,91.3,103.9,76.8,134.5,98.9,94.6,74.8,85.5,95.7,97.3,87.4,106.8,90,71.9,68.8,109.2,126,255.4,92.7,75.5,92.6,70.2,88.6,111.5,32.1,36.7,41.1,41.8,37.5,45.9,38.6,30.9,29.5,46.9,54.1,109.6,39.8,32.4,39.8,30.1,38.1,47.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NV31","U3 small nucleolar ribonucleoprotein protein IMP3 [OS=Homo sapiens]",18,2,3,2,184,21.8,9.5,9.73,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","IMP3","ENSG00000177971","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","IL-18 signaling pathway",0.679,0.677,0.652,0.648,0.672,94.1,93.9,90.4,138.7,89.8,93.1,97.8,94.3,86.7,90.7,94.1,95.8,95,90.6,85.9,139,127.4,156.1,93.1,82.9,90.1,93.3,92.8,94.4,262.4,253,232.4,243.1,252.4,256.8,254.7,243,230.3,372.7,341.7,418.6,249.8,222.4,241.5,250.3,248.9,253.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96C57","Uncharacterized protein C12orf43 [OS=Homo sapiens]",3,1,1,1,262,28.2,9.42,2.42,"cell-cell signaling;signal transduction;other biological processes","nucleus","","CUSTOS","ENSG00000157895","","","",0.679,0.705,0.804,0.72,0.696,88.5,91.9,104.8,130.3,93.9,90.7,86.2,88.4,105.6,97.4,91.8,88,104.7,105.3,101.1,132.7,109.6,130.2,93.8,89.2,101,100.6,90.7,83.7,149.3,153.1,182.7,168.6,159,152.4,181.3,182.3,175,229.8,189.7,225.4,162.4,154.5,174.8,174.2,156.9,144.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y2X9","Zinc finger protein 281 [OS=Homo sapiens]",1,1,2,1,895,96.9,8.48,4.27,"developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF281","ENSG00000162702","","","Mesodermal commitment pathway",0.679,0.755,0.67,0.706,0.644,91.5,101.7,90.2,134.7,95.1,86.8,89.8,88.4,98.1,100.6,99.9,99,85.9,102.9,88.6,123.5,158.4,132.2,79.5,101.4,93.4,89.3,84,85.2,69.6,68.5,76.1,78,77.5,76.8,66.6,79.8,68.7,95.8,122.9,102.6,61.6,78.6,72.4,69.3,65.1,66.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q13049","E3 ubiquitin-protein ligase TRIM32 [OS=Homo sapiens]",2,1,2,1,653,71.9,6.98,5.32,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","TRIM32","ENSG00000119401","Ubiquitin mediated proteolysis","Antigen processing: Ubiquitination & Proteasome degradation; Regulation of innate immune responses to cytosolic DNA","Ciliopathies",0.68,0.678,0.732,0.64,0.665,92.8,92.6,99.9,136.5,87.3,90.8,86.3,91.5,90.2,90,103.5,87.4,101.4,81.2,97.2,131.5,132.7,178.4,81.3,84.9,90.1,97.7,86.3,88.3,64.4,68.3,67.3,67.2,77.2,65.2,75.6,60.6,72.5,98.1,99,133.1,60.6,63.3,67.2,72.9,64.4,65.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O15446-1","DNA-directed RNA polymerase I subunit RPA34 [OS=Homo sapiens]",17,3,3,3,510,55,8.51,13.7,"RNA metabolism OR transcription;other metabolic processes;signal transduction","cytosol;mitochondrion;nucleus;other cell component","other molecular function","POLR1G","ENSG00000117877","RNA polymerase","B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","",0.68,1.057,0.97,1.008,0.796,74,115.1,105.6,108.9,109.7,86.7,60.4,72.6,111.8,104.5,113,115,117.6,97.5,103.6,128.6,89.6,106.9,107.7,103.2,110.4,108.1,64.4,85.1,31,37.3,57.4,53.7,58,59,60.4,50.1,53.2,66.1,46,54.9,55.3,53,56.7,55.5,33.1,43.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NZL3","Zinc finger protein 224 [OS=Homo sapiens]",11,4,7,1,707,82.2,8.69,10.24,"other biological processes","other membranes;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF224","ENSG00000267680","Herpes simplex virus 1 infection","Generic Transcription Pathway","",0.68,0.881,0.741,0.629,0.725,87.7,113.5,95.5,128.9,81.1,93.4,88.5,109.5,94,122.1,91.1,121.8,102.4,101,108.5,138.2,156.2,6.5,91.9,87,83.9,100.7,96.6,100.2,60.2,74.5,63.9,83,62,82.8,69.6,68.7,73.8,94,106.3,4.4,62.5,59.2,57.1,68.5,65.7,68.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q14592","Zinc finger protein 460 [OS=Homo sapiens]",6,2,3,1,562,63.6,7.01,8.68,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF460","ENSG00000197714","Herpes simplex virus 1 infection","Generic Transcription Pathway","",0.68,0.789,0.698,0.754,0.564,91,105.5,93.4,133.8,100.9,75.4,66.5,117.1,90,104.4,107.7,84.2,86.1,97.2,92.4,128.9,132.3,160.8,105.3,99.8,83,97.7,71.9,74.6,16.7,29.3,22.5,26.1,26.9,21.1,21.5,24.3,23.1,32.3,33.1,40.2,26.4,25,20.8,24.5,18,18.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q712K3","Ubiquitin-conjugating enzyme E2 R2 [OS=Homo sapiens]",8,3,5,3,238,27.1,4.42,10.97,"protein metabolism;other metabolic processes","cytosol","other molecular function","UBE2R2","ENSG00000107341","Ubiquitin mediated proteolysis","Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes","",0.68,0.71,0.649,0.647,0.7,93.1,97.1,88.8,136.8,88.5,95.7,90.8,96.9,95.3,98.5,99.5,102.5,89.9,90.9,94.4,140.9,140.2,95.5,99.4,85.1,90.7,98.1,99.1,92.1,719.4,767.1,755.2,780.5,788.3,811.6,712.3,720.2,747.8,1116.3,1110.1,756.1,787.4,674.1,718.5,776.6,785.1,729.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q13356","Peptidyl-prolyl cis-trans isomerase-like 2 [OS=Homo sapiens]",15,6,7,6,520,58.8,8.78,23.9,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","other molecular function","PPIL2","ENSG00000100023","Ubiquitin mediated proteolysis","Basigin interactions","",0.68,0.638,0.706,0.703,0.703,92.2,86.4,95.6,135.4,95.2,95.2,96.9,91.7,90.8,87.2,74,85.9,95.1,97.1,94.1,134.8,156.1,117.5,94.7,99.5,94,104.1,91.8,94.7,322.2,304.7,301.9,289.7,245.9,285.6,316.2,322.6,312.7,447.9,518.9,390.5,314.8,330.5,312.4,346,305,314.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y4X4-1","Krueppel-like factor 12 [OS=Homo sapiens]",4,2,2,1,402,44.2,9.7,3.52,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","KLF12","ENSCANG00000041690; ENSG00000118922; ENSGGOG00000004142; ENSMFAG00000002684; ENSMLEG00000030485; ENSMMUG00000019097; ENSMNEG00000039444; ENSNLEG00000016131; ENSPANG00000007736; ENSPPAG00000031325; ENSRBIG00000037086; ENSRROG00000027231","","","",0.681,0.76,0.835,0.77,0.7,86,96,105.6,126.4,97.4,88.5,68.9,111.5,91.1,101.7,69.9,104.9,95.7,135.1,111.7,133.8,161.9,19.8,80.3,103.1,113.1,123.5,80.2,93.7,22.8,36.9,30.1,33.6,23.1,34.7,31.7,44.7,37,44.3,53.6,6.6,26.6,34.1,37.4,40.9,26.5,31,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q15050","Ribosome biogenesis regulatory protein homolog [OS=Homo sapiens]",34,11,31,11,365,41.2,10.7,88.7,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","nucleus;other cell component","nucleic acid binding activity","RRS1","ENSG00000179041","","","",0.681,0.621,0.644,0.697,0.658,95,86.6,89.8,139.5,97.2,91.8,87.6,96.5,106,94.5,84.1,88,91.2,91.3,84.1,141.7,158,109.3,100,98.8,90.2,96.5,93.2,89.1,2562.4,2823.5,3101.9,2764.9,2461.9,2575,2669.6,2670.3,2461.5,4147.3,4623,3198.8,2925.6,2889.9,2638.6,2825,2727.2,2607.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q99576","TSC22 domain family protein 3 [OS=Homo sapiens]",43,4,5,3,134,14.8,4.54,11.75,"stress response;other biological processes","cytosol;nucleus","","TSC22D3","ENSG00000157514","","Stimuli-sensing channels","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway",0.681,0.603,0.601,0.583,0.679,98.5,87.2,87,144.7,84.3,98.2,99.4,108.1,99.1,88,80.2,97.5,84.3,87.8,106,146,153.2,97.2,91.4,85.1,82.3,99.1,106.1,89.2,512.9,557.4,511.2,454,413.5,502.9,435.1,452.9,547,753.2,790.2,501.5,471.3,439,424.3,511.1,547.2,460.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q7Z3B3","KAT8 regulatory NSL complex subunit 1 [OS=Homo sapiens]",3,2,4,2,1105,121,8.81,11.4,"protein metabolism;other metabolic processes","nucleus;other cell component","other molecular function","KANSL1","ENSG00000120071","","HATs acetylate histones","Pathways affected in adenoid cystic carcinoma",0.681,0.82,0.669,0.724,0.644,90,108.4,88.4,132.2,95.7,85.2,84.5,81.9,81.8,94.3,114.8,98.6,75.9,86.4,80.4,120.2,120.2,269,73.9,88.4,87.1,77.5,76.6,88.4,89.7,86.9,86.8,100.1,121.9,104.7,80.5,91.7,85.4,127.6,127.6,285.6,78.5,93.8,92.4,82.2,81.3,93.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96SN8","CDK5 regulatory subunit-associated protein 2 [OS=Homo sapiens]",11,18,26,18,1893,214.9,5.58,81.9,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","CDK5RAP2","ENSG00000136861","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",0.681,0.721,0.693,0.733,0.71,90.1,95.4,91.6,132.2,96.9,93.9,84,88.6,85.3,88,90.3,91.8,82.9,86.7,88.5,121.4,125.1,227.8,91.7,88.1,93.1,89.5,88.9,88.4,1777.2,1875.7,1804.8,1862.8,1910.8,1943.2,1753.9,1835.9,1872.8,2568.7,2649,4821.5,1942,1864.9,1970.4,1894.9,1880.8,1870.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q1ED39","Lysine-rich nucleolar protein 1 [OS=Homo sapiens]",18,7,10,7,458,51.6,9.86,29.03,"","nucleus","","KNOP1","ENSG00000103550","","","",0.682,0.596,0.642,0.69,0.628,96.5,84.4,90.9,141.6,97.6,89,96.2,97.1,93.6,90.4,84.1,82.3,92.1,90.6,81.7,152.7,141.1,140.9,95.6,97.3,98.9,88.7,86.4,90.5,510,515,496.4,479.2,445.9,436.4,488.2,480.3,433,809.9,748.2,747,506.9,516,524.6,470.2,458.1,480.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P25054-1","Adenomatous polyposis coli protein [OS=Homo sapiens]",0,1,1,1,2843,311.5,7.8,0,"cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","APC","ENSG00000134982","Wnt signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Regulation of actin cytoskeleton; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; MicroRNAs in cancer; Colorectal cancer; Endometrial cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer","Deactivation of the beta-catenin transactivating complex; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; S33 mutants of beta-catenin aren't phosphorylated; S37 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; T41 mutants of beta-catenin aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Ovarian tumor domain proteases; Apoptotic cleavage of cellular proteins; APC truncation mutants are not K63 polyubiquitinated","Microtubule cytoskeleton regulation; Alzheimer's disease and miRNA effects; Gastric cancer network 1; Brain-derived neurotrophic factor (BDNF) signaling pathway; Endoderm differentiation; Extracellular vesicle-mediated signaling in recipient cells; Copper homeostasis; Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; Regulation of Wnt / B-catenin signaling by small molecule compounds; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Ciliary landscape; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Malignant pleural mesothelioma; Regulation of actin cytoskeleton; Cohesin complex - Cornelia de Lange syndrome; Alzheimer's disease; DNA damage response (only ATM dependent)",0.682,0.71,0.795,0.749,0.824,86,89.4,100.2,126.1,94.4,103.9,84.1,84.4,99.5,87.8,103.4,84.1,98.4,87.1,104.1,103.1,123.7,161.5,104.3,85.5,92.7,91,102,103.3,121.9,122.4,144.3,127.4,150,122,142.7,126.3,151,149.6,179.5,234.2,151.3,124.1,134.4,132,148,149.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P09661","U2 small nuclear ribonucleoprotein A' [OS=Homo sapiens]",44,9,24,9,255,28.4,8.62,66.92,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity","SNRPA1","ENSG00000131876","Spliceosome","mRNA Splicing - Major Pathway; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","mRNA processing",0.682,0.506,0.545,0.519,0.593,106.4,78.9,85.1,156.1,81,92.5,101.8,110.8,92.2,75.5,75.5,116.2,81.4,73.7,87.4,124.2,149.2,161.3,89.7,76.6,77.4,88,130.6,88.5,2737.9,2980.5,2480.8,2030.3,2030,3125.1,2187.8,1981.8,2350.5,3340.8,4013.8,4338.6,2411.7,2058.9,2082.7,2365.7,3511.4,2380,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q86YP4","Transcriptional repressor p66-alpha [OS=Homo sapiens]",24,11,19,10,633,68,9.94,54.75,"DNA metabolism;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","GATAD2A","ENSG00000167491","","HDACs deacetylate histones; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of PTEN gene transcription; Potential therapeutics for SARS; RNA Polymerase I Transcription Initiation; Regulation of TP53 Activity through Acetylation","",0.682,0.699,0.681,0.732,0.694,91.2,93.5,91,133.7,97.9,92.7,84.7,85.4,88.4,89.4,87.5,86,95.2,85,85.2,118.3,125.2,234.3,91.7,92.3,88,85.8,86.8,91.1,1317.7,1328.6,1374.9,1391.6,1362,1337.9,1480.8,1322.2,1325.8,1840.2,1947.7,3645.2,1426.6,1436.7,1368.8,1334.4,1351,1417.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O95905","Protein ecdysoneless homolog [OS=Homo sapiens]",15,6,10,6,644,72.7,4.87,14.3,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","ECD","ENSG00000122882","","","",0.682,0.681,0.679,0.742,0.709,91.1,90.9,90.7,133.5,99,94.7,91.4,86,92.3,89.9,95.4,91.2,91,88.8,93.7,123.7,134,148.2,101.6,99.4,96.5,84.2,97.6,95,505.1,475.2,509.6,496.3,527.2,504,502.7,490.5,517.3,683.1,740.1,818.3,561.1,549,533.2,465.2,538.9,524.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NVR0","Kelch-like protein 11 [OS=Homo sapiens]",3,2,2,2,708,80.1,6.16,1.77,"","cytosol","","KLHL11","ENSG00000178502","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",0.682,0.839,0.74,0.835,0.763,84.3,103.6,91.4,123.5,103.1,94.2,76.6,83.7,84.9,102.8,102.3,119.6,122.4,86.7,90.7,122.6,133.4,104.3,82.5,107.4,102.4,85.6,93.5,98.4,133.1,145.3,147.5,178.6,177.6,207.7,212.6,150.6,157.5,212.9,231.6,181.2,143.3,186.6,177.8,148.7,162.4,170.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O75674","TOM1-like protein 1 [OS=Homo sapiens]",5,1,2,1,476,53,5.24,10.18,"protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","TOM1L1","ENSG00000141198","","","",0.683,0.742,0.617,0.734,0.652,92.6,100.5,83.6,135.5,99.5,88.3,80.8,91.4,91.9,99.2,104.9,97.6,96.9,82.1,82.5,88.7,133.8,200,90.3,98.2,105.4,87.2,76.7,92.6,39.4,44.6,44.9,48.5,51.2,47.7,47.3,40.1,40.3,43.3,65.3,97.7,44.1,48,51.5,42.6,37.5,45.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["A6ND36-1","Protein FAM83G [OS=Homo sapiens]",3,2,2,2,823,90.8,6.39,5.4,"signal transduction","cytosol;nucleus","other molecular function","FAM83G","ENSG00000188522","","","",0.683,0.73,0.77,0.814,0.803,85.4,91.2,96.2,125,101.8,100.3,83.5,82.6,89.7,89.2,101,83.2,88.4,94,104.6,122.2,104.1,199.4,99.9,99.5,85.6,76.1,98.1,99.1,52.1,51.6,56,55.7,63.1,51.9,55.2,58.7,65.3,76.3,65,124.5,62.4,62.1,53.4,47.5,61.2,61.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8NEU8-1","DCC-interacting protein 13-beta [OS=Homo sapiens]",14,5,11,4,664,74.4,4.94,41.69,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component","other molecular function","APPL2","ENSG00000136044","","","",0.683,0.738,0.67,0.614,0.71,92.9,100.3,91,135.9,83.4,96.5,95.1,93.7,89.1,98.9,101.2,102.5,86.1,93.6,91.9,138.6,137.2,132.7,95.6,84.2,81.6,79,97.4,101.7,181.5,178.9,170,188.7,193.2,195.5,164.3,178.7,175.4,264.6,261.8,253.2,182.6,160.7,155.7,150.8,185.8,194.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96F63","Coiled-coil domain-containing protein 97 [OS=Homo sapiens]",31,7,10,7,343,38.9,4.59,30.77,"","","","CCDC97","ENSG00000142039","","","",0.683,0.755,0.799,0.777,0.692,87.1,96.2,101.9,127.5,99.1,88.2,79.3,84.7,105.9,98.9,93.5,89.6,99.8,99.1,91.4,123.9,118.3,152.9,108.4,95.2,96.3,103.1,85.7,73.9,467.1,498.9,624.1,582.4,550.8,527.8,587.8,583.5,538.6,729.9,697.2,900.6,638.7,561,567.3,607.6,505.1,435.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q13242","serine/arginine-rich splicing factor 9 [OS=Homo sapiens]",27,8,19,8,221,25.5,8.65,46.65,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","SRSF9","ENSG00000111786","Spliceosome; Herpes simplex virus 1 infection","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript","mRNA processing",0.684,0.775,0.823,0.838,0.785,83.6,94.9,100.7,122.3,102.5,96,83.4,78.5,104,97.4,94.6,76.8,100.4,101.8,92.7,122,110.7,123.3,111.8,101.7,102.2,110.5,95.8,92.4,1739.2,1636.7,2168.7,2030.3,1972.4,1600.5,2093.1,2122.4,1932.5,2544,2308.7,2570.5,2330.4,2120.3,2131.3,2304,1996.3,1927.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q12986","Transcriptional repressor NF-X1 [OS=Homo sapiens]",10,10,15,10,1120,124.3,8.24,31.66,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NFX1","ENSG00000086102","Human papillomavirus infection","","Fas ligand pathway and stress induction of heat shock proteins",0.684,0.703,0.683,0.67,0.678,92.9,95.5,92.7,135.8,91,92.1,95.2,90,93.5,96.1,95.8,96.2,96.8,91.9,93.3,141.7,136.7,122.2,91.5,92,89.1,95.6,89.8,92.6,1407,1330.1,1381.6,1421.1,1415.6,1422.7,1431.5,1358,1379.7,2094.6,2020.4,1806.5,1353.4,1359.7,1317.4,1414,1328.3,1369.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q5T3I0","G patch domain-containing protein 4 [OS=Homo sapiens]",36,16,26,16,446,50.4,9.63,81.55,"","","","GPATCH4","","","","",0.685,0.662,0.696,0.746,0.697,91.6,88.6,93.1,133.7,99.8,93.2,89.9,92,95.1,89,89.5,84.3,91.8,93.6,93.5,123.7,134.4,146.5,100.7,91.5,100.2,97,93.7,93.7,2166.5,2218.3,2292.4,2145.6,2155.9,2031,2212.7,2255.4,2254,2980.1,3238.9,3530.2,2425.8,2204,2416,2338.5,2257.2,2257.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96GY0","Zinc finger C2HC domain-containing protein 1A [OS=Homo sapiens]",7,2,3,2,325,35.1,9.82,8.43,"","","other molecular function","ZC2HC1A","ENSG00000104427","","","",0.685,0.744,0.864,0.774,0.707,86.1,93.5,108.6,125.7,97.3,88.8,85.6,76.7,111.4,96.7,92.9,77.6,107.9,117.7,98,125.2,124.9,124.3,96.7,86.5,105.1,107.9,76.8,88.3,51.9,46.6,67.7,58.7,56.4,47.1,65.5,71.5,59.5,76,75.8,75.4,58.7,52.5,63.8,65.5,46.6,53.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96SD1","Protein artemis [OS=Homo sapiens]",3,2,3,2,692,78.4,6.02,5.44,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","DCLRE1C","ENSG00000152457","Non-homologous end-joining; Primary immunodeficiency","Nonhomologous End-Joining (NHEJ)","ATM signaling in development and disease ; Non-homologous end joining; DNA repair pathways, full network",0.685,0.701,0.7,0.673,0.67,92.8,95,94.8,135.5,91.2,90.7,93,93.1,90.7,95.2,120.6,82.6,94.9,102.5,72.9,137.4,123.6,135.7,101.8,87.6,91.3,90.9,89.6,96.6,145.1,145.3,141.5,148.5,188.2,128.9,148.2,160,113.7,214.5,192.9,211.7,158.9,136.7,142.5,141.8,139.7,150.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O43739","cytohesin-3 [OS=Homo sapiens]",18,6,17,2,400,46.3,5.47,57.64,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","CYTH3","ENSG00000008256","Phospholipase D signaling pathway; Endocytosis; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection","Intra-Golgi traffic","Insulin signaling",0.685,0.757,0.757,0.695,0.696,89.6,99,99,130.7,90.8,91,83.4,80.2,88.3,106,90.2,92.1,92.1,96.4,90.3,116.7,121.6,226.3,84.6,93.6,82.7,83.7,87,84.7,419.2,403.4,444.1,532.8,453.7,463.2,463.2,484.8,454.1,586.6,611.6,1137.7,425.1,470.4,415.9,420.8,437.3,426,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8IZN3-1","Probable palmitoyltransferase ZDHHC14 [OS=Homo sapiens]",2,1,1,1,488,53.4,8.24,1.87,"protein metabolism;other metabolic processes;transport","other membranes;ER/Golgi","other molecular function","ZDHHC14","ENSG00000175048; ENSGGOG00000012728; ENSPPYG00000017128","","","",0.686,0.941,0.74,0.903,0.887,79.8,109.5,86.1,116.3,105.1,103.2,74.9,101.7,79.1,117.5,108.6,88.3,85.4,76.9,119.4,115.4,95.9,120.4,96.4,104.3,122.9,102.3,83.4,107.2,22.6,30.7,23.9,35.4,32.7,26.6,25.8,23.2,36,34.8,28.9,36.3,29.1,31.4,37.1,30.9,25.2,32.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NVQ4-1","Fas apoptotic inhibitory molecule 1 [OS=Homo sapiens]",4,1,3,1,179,20.2,5.83,3.37,"developmental processes;signal transduction;other biological processes","other cell component","","FAIM","ENSG00000158234","","","",0.686,0.7,0.722,0.794,0.803,87.5,89.3,92.1,127.5,101.2,102.4,84.5,77.1,82.3,84,96.2,81.5,86.6,88.7,80.1,120,109.8,251,85.1,96.8,95.2,87,96.4,97.6,125.6,114.6,122.4,124.9,143.1,121.2,128.8,131.9,119.1,178.4,163.3,373.1,126.5,143.9,141.6,129.3,143.3,145.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BVX2","Transmembrane protein 106C [OS=Homo sapiens]",7,1,2,1,250,27.9,6.77,10.13,"","other membranes;ER/Golgi","","TMEM106C","ENSG00000134291","","","",0.687,0.77,0.775,0.773,0.715,87.3,97.9,98.5,127.1,98.2,90.9,87.1,98.5,81.7,112.3,92.9,97.7,98.3,103,73.8,104.2,133.3,126.9,111.7,98.1,96.7,90.8,89.4,103.4,48.8,55.1,45.7,62.8,52,54.7,55,57.7,41.3,58.3,74.6,71,62.5,54.9,54.1,50.8,50,57.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q99996-2","Isoform 2 of A-kinase anchor protein 9 [OS=Homo sapiens]",29,95,152,1,3907,452.7,4.98,440.93,"cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","AKAP9","ENSG00000127914","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Signaling by BRAF and RAF1 fusions; Phase 3 - rapid repolarisation; Phase 2 - plateau phase","G protein signaling pathways; NO/cGMP/PKG mediated neuroprotection",0.687,0.698,0.734,0.659,0.817,89.7,91.1,95.9,130.6,86.1,106.7,105.1,85.8,90.1,91.6,87.7,103.9,100.1,96.4,93.5,135.9,108.7,131.3,80.7,86.6,93.1,94.4,107.8,107.2,67.3,55,57.7,58.6,56.2,66.5,64.1,61.7,59.8,87,69.6,84.1,51.7,55.4,59.6,60.5,69,68.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P98155-1","very low-density lipoprotein receptor [OS=Homo sapiens]",1,1,1,1,873,96,4.79,1.97,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","VLDLR","ENSG00000147852","Spinocerebellar ataxia; Lipid and atherosclerosis","VLDLR internalisation and degradation; Reelin signalling pathway; VLDL clearance","Familial hyperlipidemia type 3",0.687,0.739,0.699,0.726,0.79,88.8,95.5,90.4,129.3,93.9,102.1,87.7,89.6,75,140.6,94.4,90,89.4,118.2,73.2,130.7,104.3,127.7,127.9,92.7,92.6,100.9,61.3,103.8,20.2,20.6,17.3,32.4,21.8,20.7,20.6,27.2,16.9,30.1,24,29.4,29.5,21.4,21.3,23.3,14.1,23.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9P2D0","inhibitor of Bruton tyrosine kinase [OS=Homo sapiens]",1,2,3,2,1353,150.4,7.71,6.83,"transport;other biological processes","other membranes;nucleus;other cell component","enzyme regulator activity;other molecular function","IBTK","ENSG00000005700; ENSG00000283068","","","",0.687,0.721,0.758,0.72,0.752,88.9,93.3,98,129.4,93.1,97.3,86.1,84.8,91.7,94.8,90.4,86.9,92.3,95,96.2,104.4,125.3,193.2,90.3,88.7,103.7,94.6,87.3,94.3,140.1,138,149.2,154.3,147.1,141.4,150.2,154.6,156.5,169.9,204,314.3,146.9,144.4,168.8,154,142.1,153.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6NS38-1","DNA oxidative demethylase ALKBH2 [OS=Homo sapiens]",18,4,5,4,261,29.3,9.66,15.01,"DNA metabolism;other metabolic processes;stress response","nucleus","other molecular function","ALKBH2","ENSG00000189046; ENSPPAG00000033974; ENSPTRG00000005418; ENSPTRG00000050273","","ALKBH2 mediated reversal of alkylation damage","Direct reversal repair",0.687,0.704,0.671,0.717,0.745,91.1,93.4,89,132.6,95.1,98.8,89.4,93.9,90.4,92.3,92.7,93.7,85.8,88.3,98.8,156.2,131.6,105.8,94.4,94.1,95.3,98,102.4,96.9,294.1,308.9,297.4,303.8,304.9,308.4,282.4,290.5,325.1,513.8,433,348.2,310.6,309.6,313.7,322.5,336.8,319,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8IWD4-1","Coiled-coil domain-containing protein 117 [OS=Homo sapiens]",11,3,3,3,279,30.5,5.07,4.93,"","","","CCDC117; FLJ33814","ENSG00000159873","","","",0.687,0.646,0.719,0.625,0.686,94.5,88.8,98.9,137.5,85.9,94.4,84.5,94.3,100,88.6,88.1,95.4,108.4,98.7,93.9,129.2,137.2,140.8,92.9,85.7,81,95.2,94.2,91.7,169.3,188.9,200.3,177.5,176.6,191.1,217,197.7,188.1,258.9,274.9,282.1,186.1,171.7,162.2,190.6,188.6,183.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BRU9","rRNA-processing protein UTP23 homolog [OS=Homo sapiens]",7,2,3,2,249,28.4,10.07,4.27,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","UTP23","ENSG00000147679","","","",0.687,0.64,0.645,0.66,0.61,97.2,90.5,91.2,141.4,93.4,86.3,99.8,100.6,92.4,88.1,101.2,93,93.6,91.3,95.6,150.5,145.2,86.9,95.9,94.3,99.7,96.7,88.6,86.8,378,381.1,350,333.7,383.4,352.2,354.7,346,362.4,570,550.1,329.2,363.3,357.3,377.7,366.4,335.8,328.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UI30","Multifunctional methyltransferase subunit TRM112-like protein [OS=Homo sapiens]",50,5,18,5,125,14.2,5.26,51.09,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","TRMT112","ENSG00000173113","","Eukaryotic Translation Termination; tRNA modification in the nucleus and cytosol; Methylation; rRNA modification in the nucleus and cytosol","",0.687,0.667,0.629,0.66,0.699,95,92.1,86.9,138.2,91.3,96.6,89.7,99,90,87.3,79.7,106.1,82.3,81.5,86.4,121.6,131,187.1,93.7,84.1,86.5,91.6,114.7,87.7,1691.4,1866.4,1697.5,1647,1503.2,2000.6,1553,1538.1,1630.5,2293.5,2469.9,3529.3,1767.1,1587.1,1631.4,1727.2,2163.2,1653.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q14596-1","Next to BRCA1 gene 1 protein [OS=Homo sapiens]",7,4,4,4,966,107.3,5.12,7.5,"other metabolic processes;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","NBR1","ENSG00000188554","Mitophagy","Pexophagy","",0.687,0.976,0.785,0.647,0.595,87.9,124.8,100.5,127.9,82.8,76.1,84.1,103,83.6,120.7,109.2,119.4,103.6,96.1,84.6,108.4,122.3,210,85,75.1,79.2,72.8,65.9,77,178.1,218.2,177.2,255.7,231.4,252.9,219.5,203.5,179.1,229.7,259.2,444.7,180.1,159.2,167.7,154.2,139.6,163.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6ZQN7","Solute carrier organic anion transporter family member 4C1 [OS=Homo sapiens]",5,2,2,2,724,78.9,7.53,6.93,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle","transporter activity","SLCO4C1","ENSG00000173930","","Neutrophil degranulation; Transport of organic anions","",0.688,0.724,0.671,0.707,0.652,92.9,97.8,90.6,135.1,95.5,88.1,86.8,89.5,107.7,94.2,103.2,85,101.9,87.3,82.9,106.1,130.1,182.9,85.6,92,97.7,78.8,84.9,103.4,95.9,98.9,119,104.1,114,93.9,112.7,96.5,91.6,117.3,143.8,202.2,94.6,101.7,108,87.1,93.8,114.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8WVC0-1","RNA polymerase-associated protein LEO1 [OS=Homo sapiens]",17,9,22,9,666,75.4,4.51,58.45,"cell-cell signaling;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","cytoskeleton;nucleus","other molecular function","LEO1","ENSG00000166477; ENSPPAG00000040132; ENSPTRG00000007081","","Formation of the beta-catenin:TCF transactivating complex; RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex ; E3 ubiquitin ligases ubiquitinate target proteins","Endoderm differentiation",0.688,0.677,0.674,0.699,0.703,93,91.5,91.1,135.1,94.4,94.9,93.9,90.3,93,94.2,91.5,89.3,94.9,90.5,91.1,131.6,137.7,135.2,94.4,96.3,91.6,95,94.2,95.4,1952.7,1877.4,1933.4,1958.7,1902.1,1857,1974.2,1881.8,1894,2735.9,2863.5,2810.7,1963.5,2002.7,1903.8,1974.6,1958.8,1984,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q7Z5W3","Pre-miRNA 5'-monophosphate methyltransferase [OS=Homo sapiens]",3,1,1,1,292,33.2,6.7,2.56,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","BCDIN3D","ENSG00000186666","","MicroRNA (miRNA) biogenesis","",0.688,0.784,0.707,0.739,0.671,90,102.5,92.5,130.7,96.6,87.7,89.2,97,86.9,104.1,101.7,99,91.7,84.8,101.3,125,136.5,129.6,97.4,95.8,91.6,85.8,95.7,86.9,72.9,79.3,71,85.1,83.1,80.9,74.9,69.3,82.8,102.2,111.6,105.9,79.6,78.3,74.9,70.1,78.2,71,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O15182","Centrin-3 [OS=Homo sapiens]",15,3,3,3,167,19.5,4.74,7.09,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","CETN3","ENSG00000153140","","","Breast cancer pathway",0.689,0.574,0.564,0.514,0.657,103.4,86.1,84.7,150.1,77.1,98.6,97,112.8,101.7,84.7,75.8,107.3,77.3,83.3,90.2,147.6,175.1,85.8,99.6,68.8,75.8,97,138.4,81.8,261.2,303.6,273.7,228,204.1,288.7,208.1,224.1,242.9,397.5,471.3,230.9,268.2,185.2,204.1,261,372.6,220.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q15036-1","Sorting nexin-17 [OS=Homo sapiens]",15,4,4,4,470,52.9,7.46,10.33,"other metabolic processes;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","SNX17","ENSG00000115234; ENSPPYG00000012549","","","",0.689,0.662,0.758,0.688,0.647,93,89.4,102.3,135,92.9,87.3,76.1,95.7,86.7,83.4,90.8,69.8,100.6,95.4,82.2,125.9,103.6,286.5,77.6,101.8,86.6,81.4,69.2,86.6,83.1,104.6,94.7,91.1,99.2,76.2,109.9,104.1,89.7,137.4,113.2,312.9,84.7,111.2,94.6,88.9,75.6,94.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q15811-7","Isoform 7 of Intersectin-1 [OS=Homo sapiens]",10,10,19,1,1215,137,7.33,57.62,"","","","ITSN1","","","","",0.689,0.807,0.755,0.84,0.753,85.4,99.9,93.5,123.9,104,93.3,69.2,71.1,70,78.9,111,81.9,85.5,76.6,73.1,101.5,92.5,398.3,85.2,76.7,91.6,69.6,76.4,90.8,120.9,124.1,122.2,137.9,193.9,143,149.4,133.9,127.6,177.3,161.5,695.6,148.9,134,160,121.5,133.5,158.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96PV7-1","Protein FAM193B [OS=Homo sapiens]",3,2,2,2,902,96.5,7.9,4.74,"","nucleus;other cell component","","FAM193B","ENSG00000146067","","","",0.689,0.621,0.571,0.619,0.612,100.6,90.6,83.3,145.9,90.4,89.2,91.2,103.9,114.1,90.3,102.8,93.6,109.8,78.9,86,159,150.7,61.8,92.3,93.3,95.9,90.7,92.2,93.5,58.2,66.3,72.9,57.7,65.6,59.8,70.1,50.4,54.9,101.5,96.2,39.4,58.9,59.6,61.2,57.9,58.9,59.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y4H2","Insulin receptor substrate 2 [OS=Homo sapiens]",1,2,3,2,1338,137.2,8.65,4.13,"other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;other molecular function","IRS2","ENSG00000185950","cGMP-PKG signaling pathway; FoxO signaling pathway; Autophagy; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Regulation of lipolysis in adipocytes; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; Growth hormone synthesis, secretion and action; Alzheimer disease; MicroRNAs in cancer","Growth hormone receptor signaling; Interleukin-7 signaling; Signaling by Leptin; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); RAF/MAP kinase cascade; PI3K Cascade; PI3K/AKT activation; Erythropoietin activates Phospholipase C gamma (PLCG); Erythropoietin activates STAT5; Erythropoietin activates RAS; SOS-mediated signalling; IRS activation; Signal attenuation","Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Farnesoid X receptor pathway; Nuclear receptors meta-pathway; Transcription factor regulation in adipogenesis; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; Nonalcoholic fatty liver disease; Insulin signaling; FOXA2 pathway; Alzheimer's disease; EPO receptor signaling; Interferon type I signaling pathways",0.69,0.813,0.749,0.677,0.651,90.4,106.5,98.1,131,88.7,85.3,92.6,89.7,87,101.1,107.9,105.7,98,86.8,97.3,129.9,124.9,157.4,94.3,83.8,88,82.3,84.6,88.5,247.7,239.8,232.6,270.4,288.6,282.5,262.1,232.2,260,347.4,334,420.8,252,224.2,235.2,220,226.1,236.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96IZ0","PRKC apoptosis WT1 regulator protein [OS=Homo sapiens]",24,6,8,6,340,36.5,5.41,19.62,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","PAWR","ENSG00000177425","","","",0.691,0.703,0.765,0.73,0.642,91.5,93.1,101.3,132.4,96.7,85,88.3,93.1,101.8,108.5,94.7,91.1,103.1,105.5,92.5,140.8,134.8,74.1,98,98.4,106,98.8,86.5,84.1,366.7,386.3,422.7,450.4,393.3,378,427.9,437.9,383.9,584.3,559.4,307.8,406.9,408.3,439.9,409.9,359.2,348.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O95391","Pre-mRNA-splicing factor SLU7 [OS=Homo sapiens]",16,8,13,8,586,68.3,7.14,34.85,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SLU7","ENSG00000164609","Spliceosome","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway","",0.691,0.72,0.638,0.653,0.611,96.1,100.2,88.8,139.1,90.8,85,96,87.7,98.9,100.1,96.7,103.3,89.7,87.8,88.7,139,131.8,156.1,90.7,93.7,86.4,85,84.8,83.6,671.2,613.1,691.9,700.2,676.6,722.3,627.7,613.8,620.4,971.9,921.8,1091.9,634.1,655.5,604.4,594.3,593.4,584.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96MW1","Coiled-coil domain-containing protein 43 [OS=Homo sapiens]",11,3,5,3,224,25.2,4.92,14.05,"","cytosol","","CCDC43","ENSG00000180329","","","",0.691,0.598,0.625,0.603,0.631,99.9,86.5,90.3,144.7,87.2,91.3,93.6,99.6,92,81.1,67.5,117.4,85.3,78.3,84.7,110,135.6,223.8,90.6,70.6,81.8,85.6,126.8,75.7,370.3,393.8,363.8,320.7,266.9,464.4,337.2,309.5,334.8,434.8,536,885,358.2,279.3,323.3,338.4,501.2,299.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NX55-2","Huntingtin-interacting protein K [OS=Homo sapiens]",6,1,1,1,129,14.7,4.93,0,"other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","HYPK","ENSCATG00000038565; ENSG00000242028; ENSGGOG00000014809; ENSMFAG00000057677; ENSMLEG00000000898; ENSMMUG00000022768; ENSMNEG00000018318; ENSPANG00000018102; ENSPPAG00000034659; ENSPTRG00000038721; ENSRBIG00000028237; ENSRROG00000039445","","","",0.692,0.69,0.758,0.66,0.725,91.7,91.6,100.5,132.6,87.5,96.2,104.2,85.4,89.7,89.6,87.7,92,94.7,98.3,102.9,122.5,149.7,129.7,96.3,85.5,72.3,94.1,117.2,88.2,44.1,36.2,38,37.9,37.2,39,40.1,41.7,43.6,51.9,63.4,54.9,40.8,36.2,30.6,39.8,49.7,37.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8N554","Zinc finger protein 276 [OS=Homo sapiens]",2,1,1,1,614,67.2,8.51,1.62,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF276","ENSG00000158805","","","",0.692,0.853,0.957,0.88,1.072,76.1,93.8,105.3,110,96.9,117.9,75.2,79.3,76.1,93.5,104.7,93.8,99.8,107.9,105.2,115.2,108.7,110,92.5,96.8,99.7,119.8,103.8,117.9,55.6,58.7,56.2,69.1,77.4,69.4,73.8,79.8,77.8,85.2,80.4,81.3,68.4,71.6,73.7,88.6,76.7,87.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q14691","DNA replication complex GINS protein PSF1 [OS=Homo sapiens]",15,2,3,2,196,23,7.39,11.33,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;developmental processes","nucleus;other cell component","","GINS1","ENSG00000101003","","Unwinding of DNA","",0.692,0.681,0.613,0.639,0.754,94.8,93.3,84,137,87.6,103.3,85.4,92.2,91.9,80.3,90.5,92,81.5,77.4,85,114.7,132.9,234.2,86.9,84.9,80.4,86.3,103.3,100.1,183.9,198.4,197.9,172.8,194.8,198,175.4,166.6,183,246.8,286.1,504.2,187.2,182.8,173.2,185.7,222.3,215.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P0C870","JmjC domain-containing protein 7 [OS=Homo sapiens]",7,1,1,1,316,35.9,5.38,6.09,"protein metabolism;other metabolic processes","nucleus;other cell component","other molecular function","JMJD7","ENSG00000243789","","","",0.692,0.719,0.675,0.734,0.768,90.5,94,88.3,130.8,96,100.4,92.6,110,92.9,96.5,86.9,107.4,90.6,76.5,91.1,111.6,136.4,134.2,74.1,101.1,98.5,103.1,73.1,123.4,18.2,21.6,18.2,18.9,17,21.1,17.8,15,17.9,21.9,26.8,26.3,14.5,19.8,19.3,20.2,14.3,24.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8TAA5","GrpE protein homolog 2, mitochondrial [OS=Homo sapiens]",19,4,6,4,225,25.4,7.72,12.08,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","other molecular function","GRPEL2","ENSG00000164284","","Mitochondrial protein import","",0.692,0.641,0.619,0.651,0.695,96.6,89.4,86.4,139.6,90.9,97,96.4,101.6,87.2,85.9,89.2,109.4,85.9,86.2,96.4,139.3,116.6,141.4,93.8,85.4,90.7,96.8,106.4,91.2,379.7,400.1,343.4,338.5,351.4,430.8,338.4,339.4,379.9,548.6,459.3,556.9,369.6,336.3,357.3,381.3,419.2,359.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q969T9","WW domain-binding protein 2 [OS=Homo sapiens]",15,4,8,4,261,28.1,5.91,16.75,"cell organization and biogenesis;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","WBP2","ENSG00000132471","","","",0.692,0.749,0.744,0.741,0.737,89.1,96.4,95.7,128.7,95.3,94.9,90.2,88.6,85.5,95.9,98.8,95.6,86.7,97.9,95.2,128,123.9,149.1,94.8,96.6,91.4,92.8,94.4,94.7,875.2,860.3,830,930.9,959,927.6,841.2,950.4,924.1,1242.8,1203.1,1447,920.5,937.9,887.7,900.7,916.5,918.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P48067-1","Sodium- and chloride-dependent glycine transporter 1 [OS=Homo sapiens]",3,2,3,2,706,78.2,7.93,10.14,"transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity","SLC6A9","ENSG00000196517","Synaptic vesicle cycle","Na+/Cl- dependent neurotransmitter transporters","Nuclear receptors meta-pathway; NRF2 pathway; Neuroinflammation and glutamatergic signaling",0.693,0.739,0.744,0.757,0.738,89,94.9,95.6,128.5,97.3,94.8,88.7,81.2,92.6,94.6,87.1,98.3,88.6,98.7,95.2,128.1,127.2,128.6,112.2,95.4,97,87,105.1,94.5,108.9,99.6,113.7,116.1,106.9,120.7,108.8,121.1,116.9,157.2,156.1,157.8,137.7,117.1,119,106.8,129,115.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q01543","Friend leukemia integration 1 transcription factor [OS=Homo sapiens]",10,3,4,3,452,51,7.06,9.38,"developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","FLI1","ENSG00000151702","Transcriptional misregulation in cancer","Transcriptional regulation of granulopoiesis","",0.693,0.737,0.736,0.652,0.696,92.1,98,97.9,132.9,86.7,92.5,85.9,94.5,91,99,96.9,94.1,104.8,96.8,88.4,129.2,131.4,150.9,89.4,84.1,85.7,90.2,96.3,91.4,251.8,277,266.8,290,283.9,275.8,307,283.6,259,378.6,385.1,442.2,262,246.4,251.1,264.3,282.3,268,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O00499","Myc box-dependent-interacting protein 1 [OS=Homo sapiens]",4,2,6,1,593,64.7,5.06,19.85,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","BIN1","ENSG00000136717","Endocytosis; Fc gamma R-mediated phagocytosis","Clathrin-mediated endocytosis","VEGFA-VEGFR2 signaling pathway; IL-18 signaling pathway",0.693,0.761,0.888,0.853,0.89,81.8,89.8,104.8,118,100.6,105,102.1,80.1,80.5,88.4,109.7,86,103.2,81.9,109.7,122.8,116.1,106.2,113.5,99.1,92.1,106.7,98.7,103.4,48.6,38.1,38.3,42.1,52.2,40.9,49.1,38.9,52.2,58.4,55.3,50.5,54,47.1,43.8,50.8,46.9,49.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NXR8-1","Inhibitor of growth protein 3 [OS=Homo sapiens]",4,1,1,1,418,46.7,6.27,3.79,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","ING3","ENSG00000071243; ENSNLEG00000033180; ENSPPAG00000029024; ENSPPYG00000017945; ENSPTRG00000019625; ENSPTRG00000047410","","HATs acetylate histones","",0.693,0.757,0.692,0.67,0.646,93.3,101.9,93.1,134.6,90.1,87,88.9,87.7,112.5,80.9,97.1,106.8,109,88.7,87.5,128.3,120,183.2,81.5,99.8,85.9,69.5,89.8,82.9,26.8,26.4,33.9,24.4,29.3,32.2,32.8,26.7,26.4,38.7,36.2,55.2,24.6,30.1,25.9,21,27.1,25,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UBR1","Beta-ureidopropionase [OS=Homo sapiens]",2,1,1,1,384,43.1,6.54,2.36,"cell organization and biogenesis;other metabolic processes","cytosol","other molecular function","UPB1","ENSG00000100024","Pyrimidine metabolism; beta-Alanine metabolism; Pantothenate and CoA biosynthesis; Drug metabolism; Metabolic pathways","Pyrimidine catabolism","Fluoropyrimidine activity; Pyrimidine metabolism",0.694,0.727,0.756,0.713,0.719,90.3,94.6,98.5,130.2,92.9,93.6,89.5,88.4,91.7,94.2,93.8,83,99.6,88.2,97.6,129,126,163.9,92,99.2,89,92.8,97,85,189.5,187.3,194.2,199.4,198.6,175.6,210.8,186.8,206.6,273.2,266.8,347.1,194.9,210.1,188.5,196.5,205.5,180,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q92187-1","CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase [OS=Homo sapiens]",7,2,2,2,359,41.3,9.74,6.59,"protein metabolism;other metabolic processes;developmental processes","other membranes;ER/Golgi","other molecular function","ST8SIA4","ENSANAG00000034757; ENSCCAG00000025138; ENSG00000113532; ENSGGOG00000011260; ENSNLEG00000035472; ENSPPAG00000033695; ENSPPYG00000015661; ENSPTRG00000042921","","Sialic acid metabolism; NCAM1 interactions","Ectoderm differentiation",0.694,0.845,0.737,0.633,0.589,92.6,112.7,98.3,133.4,84.4,78.6,71.5,75,73.1,94.7,87.4,89,62.8,82.2,77.6,99.9,105.3,472.1,66.2,73.9,66.7,62.1,61.7,78.8,65.4,68.5,66.8,86.6,79.8,81.3,57.4,75.1,71,91.3,96.3,431.4,60.5,67.5,60.9,56.7,56.4,72,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q13094","lymphocyte cytosolic protein 2 [OS=Homo sapiens]",3,1,2,1,533,60.2,6.27,7.24,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","","LCP2","ENSG00000043462","Rap1 signaling pathway; Osteoclast differentiation; Platelet activation; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; Yersinia infection","FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; GPVI-mediated activation cascade; Generation of second messenger molecules; DAP12 signaling","T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Modulators of TCR signaling and T cell activation; T-cell receptor (TCR) signaling pathway",0.694,0.809,0.847,0.853,0.787,83.5,97.2,101.8,120.2,102.5,94.7,76.8,84.1,114.8,102.5,86.9,98,119.6,102.6,100,153.8,121.2,47,118.7,86.2,103.3,119.2,95.4,69.9,118.6,129.9,177.2,158.2,134.1,151.3,184.7,158.4,154.4,237.5,187.1,72.6,183.3,133.1,159.5,184,147.3,107.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UGY1","Nucleolar protein 12 [OS=Homo sapiens]",21,3,4,2,213,24.6,10.23,16.79,"","nucleus","nucleic acid binding activity;other molecular function","NOL12","ENSG00000273899","","Major pathway of rRNA processing in the nucleolus and cytosol","",0.694,0.668,0.622,0.678,0.626,97.1,93.5,87,139.9,94.9,87.5,88.8,99,98.8,95,102.8,87.8,93.5,88.5,87.4,118.7,145,142.2,98.6,96.5,87.7,89,91.5,89,171.8,191.6,191.1,183.9,198.9,170,180.9,171.2,169.1,229.7,280.6,275.2,190.7,186.7,169.8,172.2,177.1,172.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P49796-1","Isoform 1 of Regulator of G-protein signaling 3 [OS=Homo sapiens]",8,3,5,3,519,56.6,4.88,15.24,"","","","RGS3","","","","",0.695,0.679,0.681,0.642,0.641,96.1,93.9,94.2,138.3,88.8,88.7,87.8,95.9,98.6,92.1,103.3,93.7,94.1,88,98.9,135.2,138.1,138.2,88.7,88.4,88.8,88.6,93.4,88.2,239.7,262,269.2,251.5,282.1,256,256.9,240.3,270,369.3,377.2,377.4,242.2,241.3,242.6,241.9,255.1,240.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P57076","UPF0769 protein C21orf59 [OS=Homo sapiens]",46,11,35,11,290,33.2,7.44,124.07,"cell organization and biogenesis;other biological processes","cytoskeleton;other cell component","","CFAP298","ENSG00000159079","","","Ciliopathies",0.695,0.665,0.642,0.667,0.738,94.6,90.5,87.4,136.1,90.8,100.5,95,96.7,90.1,91.2,90.9,83.2,85.9,87.7,97.4,136.7,144.6,117.5,104.3,86.1,91.2,101.2,100.9,99.3,2456.1,2501.1,2331,2359.7,2350.5,2150.4,2221.1,2269.2,2519.9,3533.9,3738.5,3039.2,2698.2,2226.3,2358.1,2617.8,2608.1,2568.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96NL6-1","Sodium channel and clathrin linker 1 [OS=Homo sapiens]",5,4,4,2,688,80.9,6.07,11.07,"cell organization and biogenesis;developmental processes","other membranes;cytosol;cytoskeleton;other cell component","other molecular function","SCLT1","ENSG00000151466","","Anchoring of the basal body to the plasma membrane","Genes related to primary cilium development (based on CRISPR); Ciliopathies",0.695,0.726,0.669,0.604,0.739,94.1,98.2,90.5,135.3,81.7,100.1,91.2,83.1,98.4,95.2,84,99,87.4,87.8,99,131.2,124.2,176,90.2,78.5,79.2,85.6,113,97,102.7,93.6,110.8,107.2,94.6,111.4,98.4,98.8,111.5,147.7,139.8,198.2,101.6,88.4,89.2,96.4,127.2,109.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H582-1","zinc finger protein 644 [OS=Homo sapiens]",6,5,5,5,1327,149.5,8.16,19,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF644","ENSG00000122482","","","",0.696,0.913,0.849,0.821,0.789,82.4,108.1,100.5,118.4,97.3,93.4,82.6,84.8,83.6,109.7,101,112,90.3,102,102.7,120.2,121.7,112.7,98.7,93.1,100.5,94.2,94.8,95.3,274.6,281.8,277.8,364.5,335.4,372.3,300,338.8,341.4,399.3,404.4,374.4,328,309.5,333.9,313.1,315,316.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P01591","Immunoglobulin J chain [OS=Homo sapiens]",38,3,20,3,159,18.1,5.24,60.44,"cell organization and biogenesis;stress response;other biological processes","non-structural extracellular","signal transduction activity or receptor binding;other molecular function","JCHAIN","ENSG00000132465","","Cell surface interactions at the vascular wall; Scavenging of heme from plasma","",0.696,0.7,0.776,0.896,0.923,83.7,84.1,93.3,120.2,107.7,110.9,81.4,83.4,90.1,88.5,83.8,79.3,91.5,96.2,93,119.8,125.3,118.5,107.3,103.8,108,110.5,107.8,111.8,876,897.2,970,952.1,901.7,853.3,985.2,1034.8,1000.5,1289,1348.9,1275,1154.8,1117.5,1162.3,1189.3,1159.9,1203.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O95295","SNARE-associated protein Snapin [OS=Homo sapiens]",14,2,4,2,136,14.9,9.31,12.19,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SNAPIN","ENSG00000143553","","Golgi Associated Vesicle Biogenesis","",0.696,0.56,0.586,0.608,0.692,100.9,81.1,84.9,144.9,88.1,100.3,96,107.8,91.4,74.6,77.2,125.2,80.8,78.7,88.3,93.5,137.9,196.8,83.8,79.8,86,95.4,121.5,85.3,142.4,160,135.6,110.6,114.5,185.8,119.9,116.7,130.9,138.7,204.6,292,124.4,118.4,127.5,141.6,180.3,126.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P81877-1","single-stranded DNA-binding protein 2 [OS=Homo sapiens]",4,1,1,1,361,37.8,6.64,0,"other biological processes","nucleus;other cell component","nucleic acid binding activity","LOC111148293; Ssbp2; SSBP2","ENSBIXG00000028003; ENSBIXG00005027806; ENSBTAG00000013856; ENSCCAG00000029743; ENSCHIG00000020381; ENSCSAG00000014933; ENSDLEG00000013445; ENSG00000145687; ENSMFAG00000044245; ENSMMUG00000017583; ENSMNEG00000029101; ENSMODG00000020258; ENSPPAG00000030611; ENSPPYG00000015606; ENSRROG00000040398; ENSSBOG00000026483; ENSSHAG00000013397; ENSSTOG00000001418; ENSUMAG00000003294; ENSVURG00010017922; ENSVVUG00000023314","","","",0.696,0.64,0.547,0.565,0.648,102,93.7,80.1,146.5,82.8,95,92.6,86.3,72.6,79.3,55.7,86.6,65,67.8,97.9,123.9,107.9,400.7,83.5,70.1,69.4,70.5,89.7,80.4,17.7,16.5,13.9,15.2,10.7,16.6,12.4,13,18.7,23.7,20.7,76.7,16,13.4,13.3,13.5,17.2,15.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q7RTS7","Keratin, type II cytoskeletal 74 [OS=Homo sapiens]",5,4,6,1,529,57.8,7.71,16.14,"cell organization and biogenesis","cytosol;cytoskeleton;other cell component","other molecular function","KRT74","ENSG00000170484","","Formation of the cornified envelope","",0.697,0.871,0.883,0.729,0.968,81.2,101.5,102.9,116.5,85,112.8,80.7,121.4,78.9,106.7,100.8,83.7,92.5,142.9,102.2,77.7,115.8,123.2,96.3,84.5,81,112.5,87.1,112.1,72.3,108.7,70.7,95.6,90.3,75,82.9,128,91.6,69.6,103.7,110.4,86.3,75.7,72.5,100.8,78,100.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8ND83-1","SLAIN motif-containing protein 1 [OS=Homo sapiens]",14,6,6,5,568,60.6,7.64,14.81,"","cytoskeleton;other cell component","","SLAIN1","ENSG00000139737","","","",0.698,0.693,0.689,0.701,0.696,93.5,92.9,92.4,134,93.9,93.3,92,98.8,95.2,100.4,89.9,94.6,97.1,94.1,93.5,136.5,152.3,85.6,92.4,95.8,95.7,93.8,95,97.5,282.1,303.1,292.1,307.9,275.7,290.1,297.8,288.5,286.8,418.6,467,262.4,283.4,293.8,293.4,287.7,291.4,298.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NSI6-1","bromodomain and WD repeat-containing protein 1 [OS=Homo sapiens]",2,5,5,5,2320,262.8,8.46,10.37,"cell organization and biogenesis;other biological processes","cytosol;nucleus","","BRWD1","ENSG00000185658","","Interleukin-7 signaling; Chromatin modifying enzymes","",0.698,0.8,0.759,0.734,0.721,88.9,101.9,96.6,127.3,93.5,91.8,87.7,87,95.1,106.9,100.6,99.8,93.3,96.9,95.4,121.2,125.7,140,88.4,92.3,95.3,89.7,94.2,90.6,314,311.4,340.5,382.7,360.2,357.1,333.8,346.9,341.3,433.7,450,501.2,316.6,330.3,341.1,321,337.1,324.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H967","WD repeat-containing protein 76 [OS=Homo sapiens]",6,4,6,4,626,69.7,9.25,12.02,"stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","WDR76","ENSG00000092470","","","",0.698,0.712,0.714,0.807,0.783,88.8,90.6,90.9,127.3,102.7,99.7,86.7,95.7,87.2,85.3,97.4,89,80.5,89.2,93.3,124.9,122.3,152.3,95.6,100.9,104.9,97.8,95.8,101.1,419.7,463.3,421.9,413,471.5,430.6,389.7,431.6,451.6,604.6,591.6,736.9,462.5,488.1,507.7,473.5,463.4,489.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9P2R6","Arginine-glutamic acid dipeptide repeats protein [OS=Homo sapiens]",0,1,1,1,1566,172.3,7.69,2.49,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","RERE","ENSG00000142599","","","",0.698,0.672,0.597,0.5,0.487,105.9,101.9,90.6,151.7,75.9,73.9,97.5,109.6,112.3,111.1,101,105.5,93.7,96.7,84.2,172.2,157,103.6,81.9,76.8,78.6,77.6,64,76.5,131,147.3,151,149.3,135.7,141.8,125.9,130,113.2,231.5,211,139.3,110,103.3,105.6,104.3,86,102.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q567V2-1","Mpv17-like protein 2 [OS=Homo sapiens]",5,1,1,1,206,23.2,9.25,0,"cell organization and biogenesis;other biological processes","other membranes;mitochondrion;translational apparatus;other cell component","","FKSG24; MPV17L2","ENSG00000254858; ENSGGOG00000008883; ENSPPAG00000039781; ENSPTRG00000010696","Peroxisome","","",0.699,0.752,0.693,0.678,0.622,94.4,101.6,93.6,135,91.5,84,87.8,82.1,84.4,90.9,89.5,93.4,83.7,82.3,88.1,105.4,120.8,327,74.8,81.9,86.2,68.7,75.2,77.8,133.3,124.6,128.1,137.9,135.9,141.8,127.1,124.9,133.8,160,183.3,496.3,113.5,124.3,130.9,104.3,114.1,118,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96LW7-1","Caspase recruitment domain-containing protein 19 [OS=Homo sapiens]",3,1,1,1,228,25.6,9.2,0,"other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus","other molecular function","CARD19","ENSG00000165233","","","",0.699,0.643,0.778,0.579,0.691,95.6,87.8,106.3,136.7,79.1,94.4,101.4,96.1,80.5,72.4,88.4,99.6,108.8,104.1,107,113.8,137.5,154.5,91,79.6,74.9,83.5,95,111.8,135.2,128.2,107.4,96.6,117.9,132.8,145.2,138.9,142.7,151.8,183.4,206.1,121.3,106.2,100,111.4,126.8,149.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q86WP2-1","Vasculin [OS=Homo sapiens]",2,1,1,1,473,53.3,7.05,2.95,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity","GPBP1","ENSG00000062194; ENSGGOG00000008390","","","",0.699,0.64,0.649,0.533,0.614,101.5,92.9,94.1,145.1,77.3,89,71,85.3,83.9,76.8,92.7,76,85.3,73.7,77.8,119.9,112.3,414.1,70.3,63.9,62.4,73.2,87.8,73.6,50.9,61.1,60.1,55,66.4,54.5,61.1,52.8,55.7,85.9,80.5,296.5,50.3,45.7,44.7,52.4,62.9,52.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96CG3","TRAF-interacting protein with FHA domain-containing protein A [OS=Homo sapiens]",15,2,3,2,184,21.4,5.11,10.43,"cell organization and biogenesis;stress response;signal transduction;other biological processes","cytosol;other cell component","","TIFA","ENSG00000145365","Shigellosis","Alpha-protein kinase 1 signaling pathway","Regulation of toll-like receptor signaling pathway; Interleukin-1 induced activation of NF-kB; MYD88 distinct input-output pathway",0.7,0.908,0.739,0.79,0.757,85.8,111.3,90.6,122.6,96.9,92.8,83.7,87,103.4,112.9,96.2,114.3,80.8,99.7,92,140.6,124.4,97.6,103.5,98.3,90.4,94.8,86.2,94.2,99.9,103.9,123.4,134.8,114.9,136.5,96.5,119,109.8,167.8,148.4,116.4,123.6,117.3,107.8,113.1,102.9,112.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96SA4","Serine incorporator 2 [OS=Homo sapiens]",2,1,1,1,455,50.7,6.19,2.22,"other metabolic processes;other biological processes","other membranes","","SERINC2","ENSG00000168528","","Serine biosynthesis","",0.7,0.813,0.705,0.888,0.849,84.8,98.4,85.4,121.1,107.5,102.8,83.3,99.9,79.7,96.7,118.8,84.9,83.9,72.4,106.7,118.9,78.2,131.3,96.3,105.6,144.2,101,92.2,106,36.2,43.5,34.7,42,51.7,36.9,36.5,31.5,46.4,51.7,34,57.1,41.9,45.9,62.7,43.9,40.1,46.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BWT3","Poly(A) polymerase gamma [OS=Homo sapiens]",6,4,6,3,736,82.8,9.14,15.55,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","PAPOLG","ENSG00000115421","mRNA surveillance pathway","","",0.7,0.796,0.69,0.665,0.654,93.2,106,91.9,133.2,88.6,87.1,92,88.9,91.6,96.6,104.1,106.6,93.8,90.3,89.5,129.6,130.8,163.7,87,85.7,93.4,82.7,85.5,88.2,233.6,225.7,232.6,245.4,264.5,270.6,238.1,229.4,227.4,329.1,332.2,415.9,221,217.7,237.3,210,217.2,224.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9P0T7","Transmembrane protein 9 [OS=Homo sapiens]",23,3,4,3,183,20.6,6.65,9.79,"cell organization and biogenesis;transport;other biological processes","non-structural extracellular;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","","TMEM9","ENSG00000116857","","","",0.7,0.715,0.745,0.747,0.804,89.2,91.1,94.9,127.3,95.2,102.4,80.9,88.4,88.8,93.1,86.6,90.3,95.1,87.4,94.1,126.2,121.4,154.5,93.5,94.4,97.9,105.3,100.5,101.6,265.4,290.1,291.5,305.6,284,296.3,312,286.8,308.8,414.3,398.5,507,306.7,309.6,321.3,345.4,329.9,333.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BW71-1","HIRA-interacting protein 3 [OS=Homo sapiens]",25,15,19,15,556,61.9,8.54,41.5,"cell organization and biogenesis","nucleus","","HIRIP3","ENSG00000149929","","","22q11.2 copy number variation syndrome; 16p11.2 proximal deletion syndrome",0.701,0.651,0.687,0.718,0.713,94.1,87.4,92.3,134.2,96.4,95.7,94.2,97.5,93.2,96.8,87.5,85.6,94.2,92.4,91.7,116.8,134.4,136.6,102,96.2,96.5,95.8,96.5,92.1,1994.8,2064.3,1973.2,2050.5,1852.6,1813.1,1996,1956.7,1943.1,2474.6,2846.4,2892.8,2160.1,2037.9,2044.2,2029.7,2044.8,1951.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6PII3","Coiled-coil domain-containing protein 174 [OS=Homo sapiens]",4,1,1,1,467,53.9,6.33,2.85,"","nucleus","","CCDC174","ENSG00000154781","","","",0.701,0.76,0.655,0.7,0.7,93.2,100.9,87.1,132.9,93,93,84,95.7,92.2,99.8,74,105.3,111.2,84.6,86.1,131.4,121.6,165.1,91.9,92.1,85.2,91.9,95.9,91.9,35.9,40.9,39.4,42.7,31.6,45,47.5,36.1,36.8,56.2,51.9,70.5,39.3,39.4,36.4,39.3,41,39.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q92624","Amyloid protein-binding protein 2 [OS=Homo sapiens]",3,2,2,2,585,66.8,6.9,6.08,"protein metabolism;other metabolic processes;transport","other membranes;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","APPBP2","ENSG00000062725","","","",0.701,0.818,0.682,0.62,0.64,94.3,110,91.7,134.5,83.4,86.1,88.2,90.4,85,102.9,102.8,104.3,79.6,90.9,85.8,125.8,115.8,252.4,77.1,82.9,78,76.5,80.5,81.1,174,178.3,167.6,203,202.8,205.7,157.1,179.2,169.2,248.1,228.3,497.8,152,163.4,153.8,150.9,158.8,159.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NW13-1","RNA-binding protein 28 [OS=Homo sapiens]",31,21,47,20,759,85.7,9.22,121.73,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity","RBM28","ENSG00000106344","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol","",0.702,0.693,0.649,0.638,0.623,97.8,96.6,90.5,139.4,88.9,86.8,97.5,96.9,93.5,96,89.1,95.7,89.7,89.5,92.2,138.1,136.9,165.9,89.2,88.1,87.1,86.1,86,82.7,6385.3,6343.5,6124.3,6287.4,5835.1,6268,5872.2,5859.5,6037.5,9041.4,8969.1,10863.1,5844,5767.7,5704.9,5636.4,5632.2,5414.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6ICH7","Aspartate beta-hydroxylase domain-containing protein 2 [OS=Homo sapiens]",8,2,2,2,369,41.7,7.5,7.3,"protein metabolism;other metabolic processes","other membranes","other molecular function","ASPHD2","ENSG00000128203","","","",0.704,0.888,0.851,0.814,0.716,84.9,107.1,102.7,120.6,98.2,86.4,93.2,68.8,72.9,92,71.4,99.9,73.1,88.2,93.2,99.3,103.6,369.9,79.5,86.1,84.3,74.2,78.6,71.9,62.4,46.1,48.8,61.6,47.9,67,49,59.1,62.5,66.6,69.4,247.9,53.3,57.7,56.5,49.7,52.7,48.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8NEJ9","neuroguidin [OS=Homo sapiens]",23,6,8,6,315,35.9,9.57,27.45,"RNA metabolism OR transcription;other metabolic processes;other biological processes","mitochondrion;nucleus;other cell component","","NGDN","ENSG00000129460","","","",0.708,0.7,0.709,0.736,0.717,92.9,91.9,93.1,131.3,96.7,94.1,84.9,86.8,85.8,84.8,84.9,85.7,87.2,80.5,86,121.3,121.2,264.3,89.3,90.8,87.7,86.9,83.7,88.1,715.5,731.4,723.1,714.2,715.3,722,734.6,677.7,724.6,1021.4,1021.2,2226.2,752.2,764.6,738.6,731.9,705,742.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96MT8","Centrosomal protein of 63 kDa [OS=Homo sapiens]",3,2,2,2,703,81.3,6.13,4.22,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;signal transduction;other biological processes","cytosol;cytoskeleton","","CEP63","ENSG00000182923","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","ATM signaling in development and disease",0.71,0.751,0.718,0.69,0.792,91.4,96.6,92.4,128.7,88.8,102,94.8,88.2,83.6,93.3,103.3,92.4,105.5,89.1,86.4,124.2,120.1,137.7,85.7,78.3,133.2,101.7,84.1,98.4,105.1,97.8,92.7,103.4,114.5,102.5,117,98.8,95.8,137.7,133.2,152.6,95,86.8,147.6,112.8,93.3,109.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8WUM9","Sodium-dependent phosphate transporter 1 [OS=Homo sapiens]",1,1,1,1,679,73.7,7.08,2.72,"other metabolic processes;transport;developmental processes","plasma membrane;other membranes","transporter activity;other molecular function","SLC20A1","ENSG00000144136","","Sodium-coupled phosphate cotransporters","",0.713,0.677,0.796,0.821,0.906,87.1,82.7,97.2,122.1,100.3,110.7,94.9,89.2,85.9,94.2,79.9,84.7,99.6,95.6,104.4,125.1,126.5,59.3,102.7,123.7,97.9,108.8,114.1,113.4,175.1,164.5,158.5,173.8,147.3,156.2,183.7,176.4,192.6,230.8,233.4,109.4,189.5,228.2,180.5,200.8,210.5,209.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O94868","F-BAR and double SH3 domains protein 2 [OS=Homo sapiens]",13,8,12,8,740,84.2,5.77,33.34,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","FCHSD2","ENSG00000137478","","","",0.714,0.752,0.735,0.799,0.772,89.8,94.5,92.5,125.7,100.4,97,92.3,87.3,90.5,95.3,96.6,88.8,93.2,93.9,90.5,127.4,126.7,124.6,92.6,102.8,101.2,93.3,97.8,105.1,771.1,728.7,756,795.6,806.7,742,778.1,784.4,755.7,1063.9,1058.2,1040.8,773.1,858.7,845.4,779.4,816.5,877.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H4M3-1","F-box only protein 44 [OS=Homo sapiens]",6,1,2,1,255,29.7,5.82,3.43,"protein metabolism;other metabolic processes;stress response","cytosol;other cell component","","FBXO44","ENSCANG00000028368; ENSCATG00000033034; ENSG00000132879; ENSGGOG00000002097; ENSMFAG00000039191; ENSMLEG00000041987; ENSMMUG00000032251; ENSPPAG00000029865; ENSPTRG00000000147; ENSRROG00000033960","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",0.72,0.788,0.827,0.831,0.751,87.9,96.1,100.9,122,101.4,91.6,97.6,86.8,71.4,80.7,99.2,95,105.1,90.3,99.7,115.4,120.6,155.9,100.2,108.9,91.6,102.4,90.6,88.8,44.9,39.9,32.9,37.1,45.6,43.7,48.4,41.5,45.9,53.1,55.5,71.7,46.1,50.1,42.1,47.1,41.7,40.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UHC7","E3 ubiquitin-protein ligase makorin-1 [OS=Homo sapiens]",7,3,7,3,482,53.3,5.14,24.45,"protein metabolism;other metabolic processes","cytosol","other molecular function","MKRN1","ENSG00000133606","","Regulation of PTEN stability and activity; Antigen processing: Ubiquitination & Proteasome degradation; AKT phosphorylates targets in the cytosol","",0.722,0.834,0.754,0.791,0.715,90,103.9,93.9,124.6,98.6,89.1,116.4,92,90.7,106.2,92.3,113.6,96.1,96,92.7,130.2,127.4,79.8,83.2,106.5,100.8,95.3,91.1,89.4,591.2,467.4,460.8,539.6,469,577.2,488.2,487.6,470.8,661.3,647,405.4,422.5,541.2,511.9,484.3,462.8,454.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q16635-1","Tafazzin [OS=Homo sapiens]",5,1,1,1,292,33.4,8.91,3.81,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","other membranes;mitochondrion","other molecular function","TAFAZZIN; TAZ","ENSG00000102125","Glycerophospholipid metabolism","Mitochondrial protein import; Acyl chain remodeling of CL","Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Envelope proteins and their potential roles in EDMD physiopathology; Hippo-Yap signaling pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Overview of leukocyte-intrinsic Hippo pathway functions",0.724,0.748,0.789,0.798,0.678,91.6,94.8,99.9,126.7,101.1,85.8,89.3,91.8,113.2,101.8,80.1,94.9,100.1,75.2,103.3,118.8,126.9,146.3,105.5,99.8,101.3,61.4,86,104.4,31.1,31.9,39.4,35.4,27.8,33,34.8,26.1,35.9,41.3,44.1,50.9,36.7,34.7,35.2,21.4,29.9,36.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q13625-1","Apoptosis-stimulating of p53 protein 2 [OS=Homo sapiens]",4,3,3,3,1128,125.5,6.07,5.12,"cell cycle OR cell proliferation;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","TP53BP2","ENSG00000143514","Hippo signaling pathway","TP53 Regulates Transcription of Death Receptors and Ligands; Activation of PUMA and translocation to mitochondria; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; Regulation of TP53 Activity through Association with Co-factors","",0.726,0.665,0.829,0.699,0.623,96,87.8,109.5,132.1,92.3,82.3,92.5,101,83.8,92.1,78.3,84.6,105.5,105.9,87.9,118.2,127.3,207.7,89,95.6,85.9,79.3,62.2,103.1,98.3,107.3,89,97.9,83.3,89.9,112.2,112.6,93.5,125.7,135.4,220.7,94.6,101.6,91.3,84.3,66.1,109.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96CJ1-1","ELL-associated factor 2 [OS=Homo sapiens]",4,1,1,1,260,28.8,5.17,2.99,"other biological processes","nucleus","other molecular function","EAF2","ENSG00000145088; ENSGGOG00000011594","","Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events","",0.73,0.797,0.777,0.72,0.697,92.7,101.3,98.7,127.1,91.5,88.6,93.5,102.3,75.7,114.5,97.5,102.2,63.2,100.7,99.5,121.4,128.2,156.6,92.3,59.7,102.4,89.3,74.4,126.5,18.2,19.9,14.8,22.3,19,19.9,12.3,19.6,19.4,23.7,25,30.5,18,11.6,20,17.4,14.5,24.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UGQ3","Solute carrier family 2, facilitated glucose transporter member 6 [OS=Homo sapiens]",4,1,1,1,507,54.5,8.63,3.78,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle","transporter activity","SLC2A6","ENSG00000160326; ENSG00000281165","","Cellular hexose transport","Nuclear receptors meta-pathway; NRF2 pathway",0.734,0.844,0.622,0.76,0.801,92.5,106.4,78.4,126,95.8,101,79,98.1,85.8,108.7,98.6,84.3,91.7,71.9,72.7,116.9,113.8,236,89.7,88.8,86.2,100.7,93.6,83.3,28.1,35,30.6,38.7,35.2,30.1,32.7,25.6,25.9,41.6,40.6,84.1,32,31.7,30.7,35.9,33.4,29.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q12830-2","Isoform 2 of Nucleosome-remodeling factor subunit BPTF [OS=Homo sapiens]",9,23,31,1,2920,324.9,7.08,79.57,"","","","BPTF","","","","",0.735,0.744,0.716,0.78,0.745,93.4,94.6,91,127.2,99.1,94.7,90.9,94.8,95.6,100.9,96,84.1,92.4,87.6,101,129.1,144,99.2,90,102.9,100.6,102.7,96.1,92,79.2,82.6,83.3,87.9,83.7,73.3,80.5,76.4,88,112.5,125.5,86.5,78.4,89.7,87.7,89.5,83.8,80.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96SI9","spermatid perinuclear RNA-binding protein [OS=Homo sapiens]",35,22,101,16,672,73.6,8.72,289.98,"other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity","STRBP","ENSG00000165209","","","",0.739,0.78,0.726,0.735,0.722,94.3,99.5,92.6,127.6,93.8,92.1,95.3,96.5,95.1,103.5,100.6,99.1,91.5,93.7,96.2,129,130.7,105.1,94.9,95.7,94.4,92.3,93.1,93.2,3304.3,3344.3,3296,3588.4,3487.9,3436.4,3169.8,3246.5,3334.3,4472.9,4530.5,3643.6,3289,3316.4,3272.1,3198.6,3227.4,3231.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q14186","Transcription factor Dp-1 [OS=Homo sapiens]",14,2,4,2,410,45,6.05,5.31,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TFDP1","ENSG00000198176","Cell cycle; TGF-beta signaling pathway","Oxidative Stress Induced Senescence; Pre-NOTCH Transcription and Translation; Transcriptional regulation of granulopoiesis; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; G1/S-Specific Transcription; Transcription of E2F targets under negative control by DREAM complex; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Inhibition of replication initiation of damaged DNA by RB1/E2F1; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Transcriptional Regulation by E2F6; Oncogene Induced Senescence; Activation of PUMA and translocation to mitochondria; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry; Activation of NOXA and translocation to mitochondria; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1","Cell cycle; Retinoblastoma gene in cancer; TGF-beta signaling pathway; G1 to S cell cycle control",0.74,0.495,0.523,0.574,0.487,116.3,77.7,82.2,157.1,90.2,76.5,119.8,117.9,127.7,55,95.3,80.1,82.4,84.7,97.6,161.9,136.5,165.8,93,94.4,67.6,62.2,78.8,79.2,17.2,16.9,18.3,7.9,13.7,11.5,11.8,12.2,14,23.2,19.6,23.8,13.3,13.6,9.7,8.9,11.3,11.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P13804-1","Electron transfer flavoprotein subunit alpha, mitochondrial [OS=Homo sapiens]",12,3,5,3,333,35.1,8.38,14.87,"other metabolic processes","mitochondrion","other molecular function","ETFA","ENSG00000140374","","Respiratory electron transport","",0.742,0.748,0.666,0.74,0.723,96.3,97.1,86.6,129.9,96.1,94,94.2,91.5,90.4,92.2,95.7,90,95.1,81,82.2,123.3,113.8,209.7,88.5,91.3,94.4,89.2,89.3,88.1,299.5,290.8,287.3,293.3,304.3,286.3,302.4,257.5,261.3,392.1,361.8,666.9,281.3,290.2,300.3,283.6,284,280.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8IX90","Spindle and kinetochore-associated protein 3 [OS=Homo sapiens]",5,2,2,2,412,46.3,5.11,4.91,"cell cycle OR cell proliferation;other biological processes","cytosol;cytoskeleton;other cell component","","SKA3","ENSG00000165480","","","",0.745,0.66,0.65,0.682,0.784,98.8,87.6,86.2,132.7,90.6,104,103,98.5,101.7,90.2,89.4,104.5,88.7,88.7,98.4,143.1,136.5,47.3,111.9,93.2,87.7,107,107.6,102.6,121.8,116.4,120.2,106.5,105.6,123.5,104.8,104.8,116.3,169.1,161.4,55.9,132.2,110.1,103.7,126.5,127.1,121.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y4K4","mitogen-activated protein kinase kinase kinase kinase 5 [OS=Homo sapiens]",2,1,1,1,846,95,7.64,3.44,"","","","","","","","",0.747,0.808,0.784,0.8,0.841,90,97.4,94.5,120.5,96.4,101.4,85.2,87.1,101.2,94.2,94.2,114,103.7,91.4,89.1,99.6,116.6,146.8,93.1,93.3,98.4,103.8,90.2,98.1,69.5,71,82.6,76.9,76.8,93,84.6,74.6,72.7,81.3,95.1,119.7,75.9,76.1,80.3,84.7,73.6,80,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q5VYS8-1","terminal uridylyltransferase 7 [OS=Homo sapiens]",20,22,38,21,1495,171.1,6.83,111.51,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TUT7","ENSG00000083223","","Deadenylation of mRNA","",0.748,0.793,0.755,0.768,0.739,93.4,99,94.4,124.9,95.9,92.4,93.9,91.9,93.5,96,100,99.1,93.2,95.8,94.4,124.1,125.8,125,94.8,97.7,96,92.2,92.4,94.1,2934,2872.8,2921.2,2999.1,3123.1,3095.3,2910.6,2994.1,2950.1,3878.7,3931.4,3905.8,2962.1,3051.1,2999.5,2880.5,2888.1,2941.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q7Z412","Peroxisome assembly protein 26 [OS=Homo sapiens]",3,1,1,1,305,33.9,6.35,1.75,"cell organization and biogenesis;transport","other membranes;cytosol;other cytoplasmic organelle","other molecular function","PEX26","ENSG00000215193","Peroxisome","Peroxisomal protein import; Class I peroxisomal membrane protein import","",0.749,0.656,0.671,0.79,0.65,99.5,87.2,89.1,132.8,105,86.4,112.7,97.9,81.7,85.8,120,83,101.8,87.7,75.3,131.9,130.6,99.3,97.8,103.2,103.3,79.8,85,123.2,134.1,116.5,97.2,102,142.8,98.7,121.1,104.3,89.6,156.9,155.4,118.1,116.3,122.8,122.8,95,101.1,146.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P30307-1","m-phase inducer phosphatase 3 [OS=Homo sapiens]",3,1,1,1,473,53.3,6.79,2.74,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","CDC25C","ENSG00000158402","Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation; Human immunodeficiency virus 1 infection; MicroRNAs in cancer","Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Activation of ATR in response to replication stress; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Cyclin A/B1/B2 associated events during G2/M transition; Polo-like kinase mediated events","miRNA regulation of DNA damage response; Cell cycle; ATM signaling pathway; CCL18 signaling pathway; DNA damage response; Monoamine transport",0.753,0.887,0.673,0.715,0.632,96.9,114.2,86.7,128.7,92.1,81.4,95.5,79.6,104.4,112.6,114.1,110.5,86.6,79.6,85.4,119.8,126.9,177,80,98.8,90.7,77.7,80.2,80.6,49.5,41.2,54.1,58.3,59.1,57.3,44.9,41.3,44.2,62.1,65.7,91.7,41.4,51.2,47,40.3,41.6,41.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O00750","Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [OS=Homo sapiens]",2,3,3,3,1634,184.7,7.3,8.8,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","PIK3C2B","ENSG00000133056","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Salmonella infection","Synthesis of PIPs at the plasma membrane","Glioblastoma signaling pathways; S1P receptor signal transduction; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; EGF/EGFR signaling pathway; Osteoblast differentiation and related diseases; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)",0.757,0.878,0.784,0.836,0.816,89.5,103.9,92.7,118.3,99,96.5,94.4,84.8,87.9,113.3,93.7,102,103.2,89.3,91,112.5,116.1,124.6,97.1,107.1,88.6,107.6,92,94.7,168.7,151.6,157,202.5,167.5,182.2,184.4,159.6,162.6,200.9,207.5,222.7,173.5,191.4,158.3,192.3,164.3,169.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96I51","RCC1-like G exchanging factor-like protein [OS=Homo sapiens]",35,9,17,9,464,50,8.4,55.64,"cell organization and biogenesis;other biological processes","other membranes;mitochondrion","enzyme regulator activity;nucleic acid binding activity;other molecular function","RCC1L","ENSG00000274523","","","",0.759,0.805,0.777,0.845,0.742,92.4,98,94.6,121.8,102.9,90.4,97.5,87.6,89.1,89.2,104,94.5,96.9,91.2,88.2,117.4,97.5,177.8,91.2,100.1,99.2,86.2,87.1,105.6,893.1,802,815.8,816.8,953,865.4,887.5,835.2,807.8,1075.2,892.8,1628.7,835.5,916.8,908.7,789.3,797.8,966.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q76N89","E3 ubiquitin-protein ligase HECW1 [OS=Homo sapiens]",3,3,3,2,1606,179.4,5.5,7.14,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","other molecular function","HECW1","ENSG00000002746","","Degradation of DVL","",0.76,0.873,0.856,1.001,0.99,83.2,95.6,93.8,109.5,109.6,108.4,94,88.2,86.8,101.3,115.1,85.8,111.3,96.1,99.3,116,136.7,1.9,116.1,97.1,139.6,114.8,85,114.8,16.5,15.5,15.2,17.8,20.2,15,19.5,16.9,17.4,20.4,24,0.3,20.4,17,24.5,20.1,14.9,20.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BYG3","MKI67 FHA domain-interacting nucleolar phosphoprotein [OS=Homo sapiens]",41,10,26,10,293,34.2,9.88,77.38,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","NIFK","ENSG00000155438","","","",0.761,0.75,0.727,0.776,0.76,95.6,94.3,91.4,125.7,97.6,95.5,94.1,96.4,97.5,95,87.9,95.3,91.6,93.4,92.1,126.7,144.3,104.4,98.8,98.3,96.8,97.5,96.3,93.4,2855.1,2923.1,2957.5,2881.7,2667,2889.8,2777.8,2831.7,2793.5,3842.1,4377.1,3166.6,2996.3,2982.4,2936.7,2957,2919.7,2832.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O75379-1","Vesicle-associated membrane protein 4 [OS=Homo sapiens]",32,3,4,3,141,16.4,7.34,8.97,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","VAMP4","ENSCATG00000035773; ENSG00000117533; ENSGGOG00000023200; ENSMFAG00000031870; ENSMLEG00000033096; ENSMMUG00000023203; ENSMNEG00000025169; ENSNLEG00000015204; ENSPANG00000022546; ENSPPAG00000028975; ENSPTRG00000001680; ENSRBIG00000031656; ENSRROG00000036404","SNARE interactions in vesicular transport","Retrograde transport at the Trans-Golgi-Network; Cargo recognition for clathrin-mediated endocytosis","",0.763,0.796,0.802,0.746,0.766,93.9,98,98.7,123.1,91.9,94.3,94.3,96.1,93.5,100.4,98.4,89,90.9,100.4,99.1,113,139.8,123.6,102.4,92.3,86.9,95.8,89.7,94.6,134.2,136.8,133.1,143,140.1,126.6,129.4,142.9,141.1,160.8,199,176,145.8,131.4,123.7,136.4,127.7,134.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P55197-1","Isoform 1 of Protein AF-10 [OS=Homo sapiens]",3,3,3,2,1027,109,8.38,6.62,"","","","MLLT10","","","","",0.764,0.758,0.706,0.795,0.744,96.1,95.4,88.8,125.9,100.1,93.7,98,88.1,102.8,97.2,83.8,99,90.5,80.7,99.4,128.2,135.6,113.5,92.1,109.9,102,95.7,88,95.5,228.7,205.7,239.9,226.9,195.7,231.2,211.2,188.5,232.1,299.4,316.5,265,215,256.5,238.1,223.5,205.4,222.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6Y7W6-1","GRB10-interacting GYF protein 2 [OS=Homo sapiens]",27,31,62,31,1299,150,5.54,158.73,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","GIGYF2","ENSG00000204120","","","VEGFA-VEGFR2 signaling pathway",0.768,0.773,0.713,0.72,0.692,98.7,99.4,91.7,128.6,92.6,89,97.3,95.9,98.3,93.7,99,98,95.4,90.3,89.7,126.8,125.7,153.7,91.8,86.2,91.3,92.8,87.7,86.6,5293.4,5214.5,5345,5094.6,5383.3,5327.4,5187.4,4913.4,4877.1,6894.2,6836.4,8359,4992.6,4689.3,4966.2,5047.1,4770.8,4709,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y5Y6","suppressor of tumorigenicity 14 protein [OS=Homo sapiens]",20,16,31,16,855,94.7,6.55,89.97,"protein metabolism;developmental processes","non-structural extracellular;plasma membrane;other membranes","other molecular function","ST14","ENSG00000149418","MicroRNAs in cancer","Formation of the cornified envelope","",0.771,0.799,0.887,0.962,0.736,89.7,93,103.3,116.4,112,85.6,89.1,86.5,91,97.5,92.3,92.2,102.5,100.6,102.6,100.7,115.6,129.7,111.5,111.2,105.4,85,104,82.4,2883.5,2801.8,2947.4,3155.1,2989.7,2985.9,3319.3,3256.8,3323,3261.2,3742.2,4199.6,3610.3,3599.8,3412.1,2752.4,3367,2668,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H3P2-1","Negative elongation factor A [OS=Homo sapiens]",38,14,42,14,528,57.2,9.03,144.18,"developmental processes;other biological processes","cytosol;nucleus","other molecular function","NELFA","ENSG00000185049","","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat","Initiation of transcription and translation elongation at the HIV-1 LTR",0.771,0.776,0.769,0.765,0.753,95.7,96.3,95.4,124.1,95,93.5,97.4,94.2,94.1,94.8,98.9,89,99.2,93.4,93.9,119.6,122.2,143,93.5,96.1,91.5,92,90.7,96.7,3268.5,3160.3,3158.7,3181.6,3318.5,2986.8,3329.4,3133.8,3152.3,4012.5,4100.4,4799.8,3137.1,3224.5,3071.4,3088.9,3043.9,3245.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96SZ6","CDK5 regulatory subunit-associated protein 1 [OS=Homo sapiens]",4,2,3,2,601,67.6,8.21,3.66,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;mitochondrion","other molecular function","CDK5RAP1","ENSG00000101391","","","",0.773,0.827,0.778,0.808,0.868,91.8,98.2,92.3,118.7,95.9,103.1,92.2,96.8,89.3,92.8,98.6,102.8,90,96,92.7,143.3,107,119.2,88,101.5,96.3,106.7,103.5,83.4,36.9,38.7,35.7,37.1,39.4,41.1,36,38.4,37.1,57.3,42.8,47.7,35.2,40.6,38.5,42.7,41.4,33.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q99700-1","Ataxin-2 [OS=Homo sapiens]",13,15,20,14,1313,140.2,9.57,56.74,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","ATXN2","ENSG00000204842","Amyotrophic lateral sclerosis; Spinocerebellar ataxia; Pathways of neurodegeneration","","Parkinson's disease pathway; EGF/EGFR signaling pathway",0.775,0.772,0.754,0.735,0.705,98.1,97.7,95.4,126.6,93,89.3,97,94.5,98.9,101.8,96.6,91.9,94,94.3,96.1,112.9,125.1,142,100.3,88.5,91.9,99.7,88.3,86.4,1751.2,1705.9,1785,1837.9,1743.4,1658.6,1696.6,1702.6,1735.9,2038.3,2259.5,2563.1,1811.5,1597.1,1660.2,1799.6,1593.5,1560.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O75420","GRB10-interacting GYF protein 1 [OS=Homo sapiens]",8,6,8,6,1035,114.5,5.39,22.65,"signal transduction","cytosol;other cell component","","GIGYF1","ENSG00000146830","","","",0.777,0.859,0.838,0.711,0.768,94.2,104,101.5,121.1,86.1,93.1,84.8,89.1,96.1,99.3,96.2,98.5,105.3,94.4,96.1,109,114.7,201.3,81.5,88.2,80.7,83.8,88.1,92.7,285.2,299.7,323.2,333.7,323.6,331,353.9,317.3,323.1,366.4,385.5,676.8,274.1,296.6,271.3,281.9,296.2,311.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UBU8-2","Isoform 2 of Mortality factor 4-like protein 1 [OS=Homo sapiens]",14,4,5,3,323,37.2,9.19,13.64,"","","","MORF4L1","","","","",0.78,0.743,0.69,0.736,0.695,100.7,96,89.1,129.2,95.1,89.8,98.7,100.6,92.7,86.4,94.1,101,92,85.2,87.4,126.5,126.6,170.3,93.2,94.6,87.7,83.6,88,91.6,328.5,334.6,308.4,287.5,313.1,336.2,306.1,283.4,290.7,421,421.4,566.8,310.3,314.8,291.8,278.1,292.8,304.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P46783","40S ribosomal protein S10 [OS=Homo sapiens]",44,8,33,8,165,18.9,10.15,71.66,"protein metabolism;other metabolic processes","cytosol;translational apparatus;nucleus","other molecular function","RPS10","ENSG00000124614","Ribosome; Coronavirus disease","Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",0.781,0.783,0.767,0.736,0.801,96.2,96.6,94.5,123.3,90.7,98.7,94.9,97.3,91.3,95.2,87.7,105.3,91,95.9,93.2,121.6,112.4,144.3,92.7,88.7,89.4,97.3,111.5,90.2,3960.2,4059.3,3810,3974.1,3660.8,4395.9,3799.1,4001.1,3889.8,5073.1,4690.5,6023.1,3869.4,3700.9,3732.6,4062,4652.4,3766.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P42694","Probable helicase with zinc finger domain [OS=Homo sapiens]",7,11,13,11,1942,218.8,7.42,37.18,"other biological processes","cytosol;nucleus;other cell component","other molecular function","HELZ","ENSG00000198265","","","",0.783,0.861,0.802,0.782,0.811,93.2,102.5,95.4,119.1,93.1,96.6,88.4,87.2,91.5,92.5,100.2,97.2,90.5,87.7,93.2,112.9,109.5,208.3,88.3,88.1,93.2,87.6,92,91.6,952.5,939.3,985,996.3,1079.3,1047.2,974.9,944.8,1003.6,1216.4,1179,2243.7,951,949.3,1004,943.9,990.4,986.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O95168-1","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [OS=Homo sapiens]",14,1,1,1,129,15.2,9.85,5.37,"cell organization and biogenesis;other metabolic processes;stress response;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB4","ENSG00000065518; ENSGGOG00000013923; ENSPPAG00000027750; ENSPTRG00000015270","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",0.784,0.913,0.823,0.802,0.865,90.6,105.6,95.2,115.6,92.8,100,70.5,77.7,75.2,86,87.7,104.1,87.7,68.9,79,76.5,96,403.6,75.5,81.6,77,74.5,95.7,83,50,55,53.3,61,62.1,73.8,62.1,48.8,56,54.2,68,286,53.5,57.8,54.6,52.8,67.8,58.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H2Y7","Zinc finger protein 106 [OS=Homo sapiens]",0,1,1,1,1883,208.8,7.15,2.19,"signal transduction","other membranes;cytosol;nucleus","other molecular function","ZNF106","ENSG00000103994","","","",0.786,0.892,0.885,0.805,0.791,91.4,103.7,102.9,116.3,93.6,92,37.6,42.6,43.2,56.1,48.4,44.4,44.4,48,60.9,43.7,54.3,1004.3,43.7,39.1,57.8,42.9,46.9,41.7,33.2,37.7,38.2,49.6,42.7,39.3,39.2,42.4,53.8,38.6,47.9,887.3,38.6,34.5,51.1,37.9,41.4,36.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NQS1","Cell death regulator Aven [OS=Homo sapiens]",21,6,10,5,362,38.5,4.98,23.75,"other biological processes","other membranes;cytosol;other cell component","","AVEN","ENSG00000169857","","Formation of apoptosome; Regulation of the apoptosome activity","",0.787,0.873,0.902,0.927,0.898,87.7,97.2,100.4,111.4,103.3,100,84.1,85.5,104,94.8,92.6,95.4,97.2,97.9,100.9,108.6,106.7,135.8,106.8,98.4,100.7,97.5,109,84,416.3,423,514.5,468.8,458.3,472,481.1,484.4,499.1,537.2,528.1,672.1,528.3,486.9,498.1,482.5,539.5,415.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8IYJ3","Synaptotagmin-like protein 1 [OS=Homo sapiens]",5,3,4,3,562,61.8,5.48,9.96,"transport","plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","SYTL1","ENSG00000142765","","TBC/RABGAPs","Deregulation of Rab and Rab effector genes in bladder cancer",0.789,0.772,0.785,0.803,0.729,97,95,96.5,123,98.8,89.7,96,95.6,98.2,97.3,93.9,91.3,98.4,85.1,95.5,106.4,121.7,155.2,104.7,97.7,97.3,82.9,88.8,94,185,184.4,189.3,187.6,181.1,176,189.8,164,184.1,205.1,234.6,299.2,201.8,188.4,187.6,159.8,171.1,181.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96F86","Enhancer of mRNA-decapping protein 3 [OS=Homo sapiens]",34,13,27,13,508,56,7.11,81.98,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","EDC3","ENSG00000179151","RNA degradation","mRNA decay by 5' to 3' exoribonuclease","",0.79,0.779,0.785,0.815,0.773,95.9,94.6,95.3,121.4,98.9,93.8,93.5,92.7,95.4,94.2,92.2,87.5,92.9,93.2,91.8,114.8,118.3,175.7,96.4,97,89.4,91.5,89.8,93.8,1624.4,1610.6,1656.7,1636.4,1601.6,1519.8,1613.8,1620.1,1594.9,1995.4,2056,3052.6,1675.5,1685.9,1552.7,1589.1,1560.1,1629,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8NG08","DNA helicase B [OS=Homo sapiens]",9,6,6,6,1087,123.2,5.87,12.19,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HELB","ENSG00000127311","","","",0.792,0.838,0.833,0.825,0.815,93.1,98.5,98,117.6,97,95.8,91.7,94.3,88.4,97,105.7,90.8,95.8,99.1,96.4,114.6,115.7,140.9,94.4,95.4,95.6,90.3,94.3,99.6,301.9,310.7,291,319.3,348.2,299.1,315.4,326.5,317.5,377.2,381.1,463.9,311,314.3,314.8,297.2,310.5,328,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q499Z4","Zinc finger protein 672 [OS=Homo sapiens]",2,1,1,1,452,50.2,9.89,2.22,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF672","ENSG00000171161","","","",0.795,0.849,0.802,0.765,0.832,94.6,101,95.4,119,91,99,94.4,94.4,91.4,100.7,106.6,99.1,90.2,103.7,95.2,114.7,131.5,118.7,83.8,95.2,90.8,84.4,106.3,98.7,63.4,63.4,61.4,67.7,71.6,66.6,60.6,69.7,64,77.1,88.4,79.8,56.3,64,61,56.7,71.5,66.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UP83-1","conserved oligomeric Golgi complex subunit 5 [OS=Homo sapiens]",18,13,21,13,839,92.7,6.6,56.78,"transport","other membranes;cytosol;ER/Golgi;nucleus","","COG5","ENSG00000164597","","COPI-mediated anterograde transport; Retrograde transport at the Trans-Golgi-Network; Intra-Golgi traffic","",0.796,0.813,0.804,0.811,0.831,94.5,96.5,95.5,118.7,96.3,98.6,93.5,91.3,95.2,97.5,95.5,89.3,99.2,94.5,94.2,106.6,117.5,151.2,98.1,95.3,94,99.1,90.4,97.6,1698.8,1659.1,1728.7,1770.8,1734.4,1622.9,1802.5,1716.7,1710.6,1935.7,2134.4,2747.3,1782.2,1731.7,1707.8,1799.8,1641.5,1773.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8IWF6","Protein DENND6A [OS=Homo sapiens]",2,1,1,1,608,69.5,8.27,2.51,"other biological processes","cytosol;other cytoplasmic organelle;other cell component","enzyme regulator activity","DENND6A","ENSG00000174839","","RAB GEFs exchange GTP for GDP on RABs","",0.799,0.808,0.743,0.775,0.797,97.4,98.5,90.5,121.9,94.5,97.1,91.5,100.3,83.6,90.6,92.5,114.6,98.8,85,83.4,105.9,114.5,197,94.3,87.7,88.8,85.8,94.4,91.3,79.2,86.8,72.3,78.4,80.1,99.2,85.5,73.6,72.2,91.7,99.1,170.5,81.6,75.9,76.9,74.2,81.7,79,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q7LBC6-1","Lysine-specific demethylase 3B [OS=Homo sapiens]",14,15,21,15,1761,191.5,7.18,59.58,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KDM3B","ENSG00000120733","Thermogenesis","HDMs demethylate histones","Thermogenesis",0.799,0.853,0.813,0.768,0.784,95.6,102,97.2,119.6,91.8,93.7,93.7,90.2,97.2,99.9,102.6,97.5,96.1,94.9,95.2,117.2,115.8,156.7,87.3,91.2,90,89,91.9,93.6,1167.3,1123.2,1210.4,1245,1278.7,1215.1,1197.3,1181.6,1186.4,1460.1,1442.7,1951.7,1087.8,1136.7,1120.8,1108.3,1144.3,1165.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UEE5","Serine/threonine-protein kinase 17A [OS=Homo sapiens]",9,3,7,3,414,46.5,5.15,6.4,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;nucleus","kinase activity;other molecular function","STK17A","ENSG00000164543","","","",0.801,0.98,0.732,0.722,0.675,97.9,119.8,89.5,122.2,88.2,82.5,98.3,92.7,112.4,122.9,115.7,120.3,89.8,95.2,83,110.9,122.7,123.9,86.1,90.2,88.6,76.6,87.8,82.8,97.7,92.1,111.7,122.1,114.9,119.5,89.2,94.6,82.4,110.2,121.9,123.1,85.6,89.7,88,76.1,87.3,82.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8TET4","neutral alpha-glucosidase c [OS=Homo sapiens]",5,2,2,2,914,104.3,6.23,6.3,"protein metabolism;other metabolic processes","","other molecular function","GANC","ENSG00000214013","Galactose metabolism; Starch and sucrose metabolism; Metabolic pathways","","",0.804,0.728,0.928,0.87,0.839,93.3,84.6,107.7,116.1,101,97.4,91.8,103.5,88.1,68.5,113.7,83.2,133.7,106,86.9,114.2,94.7,114.8,99.4,107.8,96.5,95.9,90.6,110.6,40.7,45.9,39.1,30.4,50.4,36.9,59.3,47,38.6,50.7,42,50.9,44.1,47.8,42.8,42.5,40.2,49.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q3KQU3-4","Isoform 4 of MAP7 domain-containing protein 1 [OS=Homo sapiens]",12,10,16,10,808,89.4,10.07,29.24,"","","","MAP7D1","","","","",0.804,0.885,0.982,0.94,0.871,88,96.8,107.5,109.4,102.9,95.3,86.6,86.7,118.7,113.4,95.3,94,105.8,109,92.5,115.2,107.8,84.9,103.6,101.3,99.5,107.8,93.9,84,1356.3,1358,1859.2,1777.4,1493.6,1472.9,1658.2,1708.3,1449.5,1804.2,1688.4,1330.6,1623.4,1587.6,1558.2,1688.7,1470.8,1315.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O00217","NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [OS=Homo sapiens]",31,6,19,6,210,23.7,6.34,49.75,"cell organization and biogenesis;other metabolic processes;stress response;transport","other membranes;mitochondrion","transporter activity;other molecular function","NDUFS8","ENSG00000110717","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",0.806,0.642,0.71,0.692,0.781,104.5,83.2,91.9,129.5,89.7,101.2,101.6,102.5,98.3,80.9,80.8,110.6,92.6,83.7,89.4,125.9,126.1,117.6,95,87.2,84.1,98.4,133.6,91.7,2154.4,2173.4,2084.7,1716.3,1714,2345.7,1963.8,1775.6,1896.4,2671.5,2675.8,2494.1,2015.8,1849.2,1784.5,2087.6,2834,1944.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96EV8-1","dysbindin [OS=Homo sapiens]",9,3,6,3,351,39.5,4.67,15.57,"cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","","DTNBP1","ENSG00000047579","","Golgi Associated Vesicle Biogenesis","",0.807,0.778,0.81,0.762,0.834,97,93.6,97.3,120.2,91.6,100.3,100.6,97.1,94.2,94.9,93.6,90.5,102.9,91.2,97.4,125.4,120.3,116.2,98.2,91.6,87,101.2,100.4,97.1,777.3,750.4,728.4,733.5,723.5,699.6,794.9,705,752.8,969.4,929.7,898.2,758.6,708,672.6,782.4,775.6,750.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8NI36","WD repeat-containing protein 36 [OS=Homo sapiens]",11,9,21,9,951,105.3,7.53,56.86,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","WDR36","ENSG00000134987","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",0.809,0.824,0.817,0.819,0.836,95.1,96.8,96,117.6,96.3,98.3,90.1,93.5,93.7,94.3,95.2,96.9,94.5,92.5,98.3,115.6,115.3,147.8,95.2,94.2,94.7,94.7,96.7,96.8,1796.3,1865.3,1869.1,1880.2,1899.1,1932.3,1883.9,1845.3,1961,2306,2298.7,2947.6,1898.9,1879.1,1888.5,1888,1927.5,1930,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q86YZ3","Hornerin [OS=Homo sapiens]",11,8,9,8,2850,282.2,10.04,22.62,"cell organization and biogenesis;developmental processes","non-structural extracellular;plasma membrane;other cytoplasmic organelle;other cell component","other molecular function","HRNR","ENSG00000197915","","Neutrophil degranulation","",0.81,0.906,0.926,0.692,0.829,94.1,105.3,107.6,116.2,80.4,96.3,84.3,97,87.1,97.5,104.8,72.3,99.6,113.6,80.5,75.9,107.6,305.5,67.4,74.4,82.9,89.1,69.2,91.3,353.1,405.9,364.6,407.9,438.6,302.6,416.9,475.4,337.2,317.9,450.2,1278.6,282.3,311.4,347.2,373.2,289.6,382.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96ES6","Major facilitator superfamily domain-containing protein 3 [OS=Homo sapiens]",2,1,1,1,412,42.7,9.17,2.16,"transport","other membranes","transporter activity","MFSD3","ENSG00000167700","","","",0.812,0.871,0.944,0.954,0.867,89.4,96,103.9,110.1,105.1,95.5,80,86.9,113.9,93.2,85.2,99.3,105.1,91.8,100.9,80.6,107,178.1,89.7,111.7,102.1,88,93.7,92.7,40.6,44.1,57.8,47.3,43.2,50.4,53.3,46.6,51.2,40.9,54.3,90.4,45.5,56.7,51.8,44.6,47.5,47,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6ZSR9","Uncharacterized protein FLJ45252 [OS=Homo sapiens]",15,4,6,4,355,38,5.26,18.58,"","","","","","","","",0.813,0.802,0.797,0.778,0.798,97.8,96.4,95.8,120.3,93.6,96,83.2,90.3,90,85.4,96.7,88.8,88.2,84.7,88.4,110.7,104.4,264.9,86.1,85.5,92.3,83.5,88.3,88.5,301.7,327.6,326.7,309.8,350.9,322,320,307.2,320.6,401.7,378.9,961.2,312.5,310.3,334.7,303,320.5,321,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q01201","Transcription factor RelB [OS=Homo sapiens]",11,6,7,6,579,62.1,6.24,18.83,"stress response;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","RELB","ENSG00000104856","MAPK signaling pathway; NF-kappa B signaling pathway; Osteoclast differentiation; C-type lectin receptor signaling pathway; Human T-cell leukemia virus 1 infection; Epstein-Barr virus infection","Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; CD209 (DC-SIGN) signaling","RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Toll-like receptor signaling related to MyD88; EDA signaling in hair follicle development; Ebola virus pathway in host; miRNAs involvement in the immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3",0.815,0.93,0.918,0.796,0.91,91,103.9,102.6,111.7,88.9,101.7,90.6,97.7,89.4,104.6,103.4,99.1,98.8,102.1,103.1,111.2,106.9,121.1,93.9,88.5,88,98.3,101.2,102.1,444.8,479.9,438.8,513.5,507.7,486.7,485.3,501.4,506,545.9,524.7,594.5,461.2,434.5,432.1,482.5,496.7,501.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96B70","Leukocyte receptor cluster member 9 [OS=Homo sapiens]",9,2,2,2,501,53.1,7.84,8.53,"","","other molecular function","LENG9","ENSG00000273574; ENSG00000274495","","","",0.816,0.858,0.951,0.765,0.838,93.6,98.5,109.2,114.7,87.8,96.2,86.6,85.7,107.8,91.9,72.9,91,100.9,101,98.3,106.1,99.9,231.6,81.2,74.1,99.5,88.9,95.3,87.2,37.9,37.6,47.2,40.3,32,39.9,44.2,44.3,43.1,46.5,43.8,101.5,35.6,32.5,43.6,39,41.8,38.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q7Z6J9","tRNA-splicing endonuclease subunit Sen54 [OS=Homo sapiens]",10,4,4,4,526,58.8,7.91,13.07,"RNA metabolism OR transcription;other metabolic processes","nucleus","","TSEN54","ENSG00000182173","","tRNA processing in the nucleus","",0.817,0.815,0.805,0.851,0.795,96.4,96.2,95,118.1,100.5,93.8,99.7,91.4,95.4,95.1,102.8,87.5,98.1,93.9,83.6,116.8,111.3,136.5,99.4,98.2,108.6,92.8,88.1,100.8,240.9,220.7,230.3,229.8,248.3,211.4,237,226.9,201.8,282,268.8,329.6,240,237.1,262.2,224.1,212.9,243.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q12788","Transducin beta-like protein 3 [OS=Homo sapiens]",31,20,48,20,808,89,6.9,147.45,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","TBL3","ENSG00000183751","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",0.819,0.828,0.842,0.847,0.863,94.5,95.6,97.2,115.4,97.7,99.6,92.2,95.7,95.6,96.5,96.7,97.2,98.4,98.8,97.3,118.2,116.8,98.2,96.2,98.9,101.5,99.3,101.9,100.8,3750.4,3891.6,3889.8,3926.3,3934.3,3952.9,4002.3,4020.5,3957.3,4810,4751.5,3994.6,3912.5,4023.8,4130.6,4038.8,4143.9,4102.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q969Q0","60S ribosomal protein L36a-like [OS=Homo sapiens]",25,4,21,1,106,12.5,10.65,50.83,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;ER/Golgi;translational apparatus;nucleus","other molecular function","RPL36AL","ENSG00000165502","Ribosome; Coronavirus disease","Major pathway of rRNA processing in the nucleolus and cytosol; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","",0.82,0.858,0.784,0.865,0.809,95.8,100.2,91.6,116.8,101,94.5,94.1,95.9,103.9,101.4,100.4,86.5,108.9,91.7,87,110.7,117,123.2,104.6,101.2,86.5,101.5,94.6,91,447.3,455.8,493.7,481.8,476.8,411,517.3,435.7,413.2,525.9,555.8,585.6,497,480.7,410.8,482.1,449.7,432.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q5MIZ7-1","Serine/threonine-protein phosphatase 4 regulatory subunit 3B [OS=Homo sapiens]",16,11,25,6,849,97.4,4.96,75.53,"protein metabolism;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","","PPP4R3B","ENSG00000275052","Glucagon signaling pathway","","Integrated breast cancer pathway; 16p11.2 proximal deletion syndrome",0.821,0.868,0.823,0.757,0.798,97.2,102.8,97.5,118.4,89.6,94.5,97.4,97.7,97.5,103.1,104.8,100.8,104,97.7,96,118.7,124.1,99.2,89.9,94.2,88.2,94.8,98.3,93.6,823.4,826,824.3,871.6,885.9,852.1,879,826.4,811.8,1003.8,1049.6,838.4,760.1,796.7,745.8,801.5,831,791.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UNX4","WD repeat-containing protein 3 [OS=Homo sapiens]",19,14,30,14,943,106,6.64,86.14,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","nucleic acid binding activity","WDR3","ENSG00000065183","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",0.824,0.822,0.837,0.848,0.864,95.2,95,96.7,115.5,97.9,99.7,95.2,96.3,94.5,95,95.8,93.6,92.2,97.8,96.7,114.5,115.6,122.3,99.1,95.5,98,99.8,100.5,97.8,3016.7,3051.3,2992.2,3009.9,3033.7,2965.9,2919.8,3097.1,3063.6,3627.5,3660.9,3874.1,3138.1,3025.8,3104.3,3161.5,3182.9,3097.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8IZ52","Chondroitin sulfate synthase 2 [OS=Homo sapiens]",2,2,2,2,775,85.4,6.93,4.16,"protein metabolism;other metabolic processes","other membranes;cytosol;mitochondrion;ER/Golgi","other molecular function","CHPF","ENSG00000123989","Glycosaminoglycan biosynthesis; Metabolic pathways","Chondroitin sulfate biosynthesis","",0.824,0.803,0.858,0.844,0.786,96.7,94.2,100.7,117.3,99,92.2,95.6,96.1,83.2,94.3,85,93.1,101.2,85.6,99.5,109.2,115.9,175.7,92.6,99.7,97.9,87.1,97.2,91.1,221.1,222.3,192.6,218.1,196.7,215.5,234.1,198.1,230.2,252.6,268.2,406.5,214.1,230.7,226.5,201.4,225,210.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P50851-2","Isoform 2 of Lipopolysaccharide-responsive and beige-like anchor protein [OS=Homo sapiens]",28,59,147,1,2851,317.5,5.57,431.19,"","","","LRBA","","","","",0.825,0.784,0.93,0.84,0.817,95.3,90.6,107.4,115.5,97,94.4,109.9,91.7,91.4,87.2,100.2,84.8,117,103.3,92.3,132.4,111.1,84,91.7,120,93.3,86.1,90.8,112.9,663.9,553.7,551.8,526.3,604.9,511.8,706.5,624,557.4,799.3,670.9,507,553.5,724.8,563.4,519.9,548.3,681.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O43463","Histone-lysine N-methyltransferase SUV39H1 [OS=Homo sapiens]",8,3,4,3,412,47.9,8.03,9.35,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SUV39H1","ENSG00000101945","Lysine degradation; Metabolic pathways","PKMTs methylate histone lysines; SIRT1 negatively regulates rRNA expression","Histone modifications; Retinoblastoma gene in cancer; Interactions between LOXL4 and oxidative stress pathway; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome",0.828,0.755,0.779,0.825,0.867,98.3,89.6,92.5,118.7,97.9,103,85.1,99.3,101.1,98.6,90.6,84.4,93.5,100.2,93,120,132.9,98.1,97.8,99,104.4,104.1,91.9,106,187,218.2,222.2,216.7,199,185.4,205.3,220.1,204.4,263.5,291.9,215.6,214.9,217.4,229.4,228.6,201.8,232.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O94992","Protein HEXIM1 [OS=Homo sapiens]",4,2,2,2,359,40.6,4.89,2.06,"stress response;developmental processes;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","HEXIM1","ENSG00000186834","","","Initiation of transcription and translation elongation at the HIV-1 LTR",0.829,1.123,1.283,1.14,0.914,79.1,107.2,122.4,95.4,108.7,87.2,76.3,71.7,123,117.4,103.3,80.1,118,123.9,112.6,130.7,92,73.2,108.8,94,104.8,115.5,84.1,70.7,158.3,148.8,255.3,243.8,214.5,166.2,245,257.3,233.8,271.4,191,152,225.8,195.1,217.7,239.7,174.5,146.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q93075","Putative deoxyribonuclease TATDN2 [OS=Homo sapiens]",2,2,2,2,761,85,7.39,2.72,"DNA metabolism;other metabolic processes","nucleus","other molecular function","TATDN2","ENSG00000157014","","XBP1(S) activates chaperone genes","",0.831,0.869,0.783,0.855,0.881,95.5,99.9,90,115,98.3,101.3,104.9,95.3,93.9,97.3,99.7,101.4,89.7,86.9,101.4,114.7,90.6,131.8,94.5,99.1,98,94.2,105.6,101.1,150,136.3,134.3,139.2,142.6,145,128.3,124.4,145.1,164,129.6,188.5,135.2,141.7,140.2,134.7,151.1,144.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6PL18-1","ATPase family AAA domain-containing protein 2 [OS=Homo sapiens]",18,20,27,18,1390,158.5,6.32,73.86,"cell organization and biogenesis;other biological processes","nucleus","other molecular function","ATAD2","ENSG00000156802","","TFAP2 (AP-2) family regulates transcription of growth factors and their receptors","Gastric cancer network 2",0.831,0.753,0.8,0.857,0.866,97.7,88.5,94,117.5,100.7,101.7,97.5,98.8,97.2,87.8,88.4,91,94,93.8,93.1,116,117.4,119.9,98.3,100.9,100.5,99.1,104.7,101.6,2449.6,2481.2,2441.1,2205,2219,2285.2,2361,2356.3,2337.3,2914.1,2947.1,3011.4,2467.7,2533.8,2524.6,2489.7,2628.1,2551,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P41440","Folate transporter 1 [OS=Homo sapiens]",13,5,10,5,591,64.8,8.95,30.77,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes","transporter activity;other molecular function","SLC19A1","ENSG00000173638","Antifolate resistance; Vitamin digestion and absorption","Metabolism of folate and pterines","Folate metabolism; Ethanol effects on histone modifications",0.832,0.804,0.87,0.944,0.924,92.9,89.7,97.1,111.6,105.4,103.2,90.4,87.5,95.8,87.3,86.6,91.3,92.5,94.5,97.1,96.4,108.6,157.9,101.8,102.5,106.9,100.4,96,106.7,620.6,601,657.5,599.1,594.4,626.8,635.1,648.7,666.6,662.2,745.5,1084.1,698.7,704.1,733.8,689.2,659.5,732.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96ST2","protein IWS1 homolog [OS=Homo sapiens]",15,12,28,12,819,91.9,4.69,65.6,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","nucleus","","IWS1","ENSG00000163166","","Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events","",0.834,0.798,0.818,0.859,0.837,97.2,93.1,95.4,116.6,100.2,97.6,99.1,96.6,97,99.1,92.8,92.8,93.5,95.2,96.8,109.4,116.3,122.7,99.9,101.6,96.6,97.3,95.7,97.6,2532.7,2470.2,2478.4,2533.2,2372.6,2371.2,2389.4,2432.9,2472.9,2797.3,2973.1,3136.9,2553.6,2595.9,2468.3,2487.6,2444.8,2494.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UPT9-1","ubiquitin carboxyl-terminal hydrolase 22 [OS=Homo sapiens]",2,1,2,1,525,59.9,8.05,0,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus","other molecular function","USP22","ENSG00000124422","","Ub-specific processing proteases; HATs acetylate histones","",0.835,0.789,0.91,0.838,0.752,97.8,92.3,106.5,117.1,98.2,88.1,99.5,94.2,98.7,93.2,86.9,101.7,107.7,107.5,101.1,100.5,118.2,134.8,99.1,87.7,99.6,88.6,88.9,92.5,114.2,108.1,113.3,107,99.7,116.7,123.6,123.4,116,115.3,135.6,154.7,113.7,100.7,114.3,101.7,102,106.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y3T6","R3H and coiled-coil domain-containing protein 1 [OS=Homo sapiens]",21,7,9,7,440,49.1,5.63,30.34,"","","nucleic acid binding activity","R3HCC1","ENSG00000104679","","","",0.836,0.816,0.814,0.804,0.824,98.5,96.1,95.9,117.8,94.7,97.1,95.6,98.2,97.8,95.4,95.2,98.7,91.2,95.2,98.5,113.2,117,127.7,92.7,94,95.9,96.4,101.6,95.4,1185.4,1217.9,1212.5,1183.3,1180.4,1224.3,1131.2,1180.6,1221,1403.8,1450.8,1583.1,1148.7,1165.9,1189.6,1195.5,1260,1183,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NVM9","integrator complex subunit 13 [OS=Homo sapiens]",27,17,39,16,706,80.2,6.7,129.07,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","nucleus;other cell component","","INTS13","ENSG00000064102","","RNA polymerase II transcribes snRNA genes","",0.836,0.85,0.845,0.856,0.823,96.3,97.8,97.3,115.2,98.6,94.8,96.7,96.1,95.6,102.1,97.7,91.8,97.1,96.7,97.3,108.9,115,121.4,98.4,96.3,99,94.6,94.7,100.6,3845.3,3824.4,3801.5,4062.4,3885,3653,3862.3,3846.2,3871.5,4330.7,4572.9,4830.8,3916,3832.5,3936.8,3762.2,3765.7,4003.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96BI3-1","gamma-secretase subunit APH-1A [OS=Homo sapiens]",5,2,3,2,265,29,7.9,9.98,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle","enzyme regulator activity;other molecular function","APH1A","ENSANAG00000030676; ENSCANG00000034955; ENSCATG00000033983; ENSCCAG00000036376; ENSCSAG00000018098; ENSG00000117362; ENSGGOG00000017118; ENSMLEG00000037901; ENSMNEG00000034177; ENSNLEG00000009799; ENSPANG00000008739; ENSPPAG00000033416; ENSPPYG00000000905; ENSPTRG00000001250; ENSRBIG00000035934; ENSRROG00000045010; ENSSBOG00000025150","Notch signaling pathway; Alzheimer disease","Amyloid fiber formation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; EPH-ephrin mediated repulsion of cells; NOTCH2 Activation and Transmission of Signal to the Nucleus; Activated NOTCH1 Transmits Signal to the Nucleus; Nuclear signaling by ERBB4; NOTCH4 Activation and Transmission of Signal to the Nucleus; NRIF signals cell death from the nucleus; Regulated proteolysis of p75NTR; Noncanonical activation of NOTCH3","Alzheimer's disease and miRNA effects; Notch signaling; Alzheimer's disease; Notch signaling pathway (Netpath); Notch signaling pathway; Delta-Notch signaling pathway",0.839,0.886,0.878,0.893,0.916,93,98.2,97.4,110.9,99,101.6,79.2,93.9,96.9,96.2,100.8,99.1,106.8,95.7,98.3,119,111.9,101.7,99.9,102.8,93.6,102.5,99.1,102.5,370,438.7,453,449.4,471.3,463.2,499.1,447.5,459.2,556.3,523,475.5,466.8,480.3,437.7,479.2,463.3,479.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O00571","ATP-dependent RNA helicase DDX3X [OS=Homo sapiens]",58,34,224,33,662,73.2,7.18,686.69,"cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function","DDX3X","ENSG00000215301","RIG-I-like receptor signaling pathway; Hepatitis B; Viral carcinogenesis","Neutrophil degranulation","Novel intracellular components of RIG-I-like receptor (RLR) pathway; Hepatitis B infection",0.84,0.838,0.834,0.835,0.816,97.6,97.4,97,116.2,97,94.8,99.4,99.3,100.9,101.9,98.9,99.2,98.5,99.4,98.8,119.9,118.4,79.5,99,98.9,98.2,96.7,95,98.2,27819.4,27775.9,28243.8,28502.1,27669.2,27766.3,27551.8,27798.2,27648.6,33554.5,33132.1,22239.6,27691.5,27657.4,27479.5,27042.3,26575.9,27463.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8NC96","adaptin ear-binding coat-associated protein 1 [OS=Homo sapiens]",23,5,11,4,275,29.7,6.8,30.33,"transport","plasma membrane;other membranes;cytosol","","NECAP1","ENSG00000089818","","Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis","",0.841,0.827,0.831,0.822,0.795,98.7,97,97.5,117.3,96.4,93.2,101.9,97.2,100.4,100.4,96.2,98.6,94.8,101.4,99.2,125.6,119.3,81.9,98,99.4,95.4,101.4,94.1,94.8,1582.8,1509.9,1558.7,1559,1493.4,1531.8,1471.8,1574.7,1539.9,1949.8,1852.6,1272.3,1522.2,1543.2,1481.1,1573.8,1461.9,1472.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P50238","Cysteine-rich protein 1 [OS=Homo sapiens]",21,2,6,2,77,8.5,8.75,14.64,"stress response;developmental processes;signal transduction;other biological processes","other cell component","other molecular function","CRIP1","ENSG00000213145","","","",0.842,0.943,1.011,1.016,0.931,88,98.5,105.6,104.5,106.1,97.3,88,84.9,100.5,101.8,98.4,84,107.4,105.6,91.8,104.4,94.9,121.3,106,109.5,100.2,108.2,97.2,95.8,1326.9,1281.3,1516.2,1536.1,1484.8,1267.2,1619.3,1592.3,1384.3,1574.9,1431.1,1829.3,1599.6,1652,1511.3,1631.7,1466.7,1445.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6ZU65-1","Ubinuclein-2 [OS=Homo sapiens]",1,1,2,1,1347,146,9.19,2.18,"","nucleus","","UBN2","ENSG00000157741","","","",0.844,0.84,0.871,0.85,0.851,96.3,95.9,99.5,114.2,97,97.1,112.4,88.3,88.7,100,88.3,80.9,94,91.6,84.4,105.1,104.9,212.7,89.3,88.3,97.4,96.5,89.4,87.9,107.8,84.7,85.1,95.9,84.7,77.6,90.2,87.9,81,100.8,100.6,204,85.7,84.7,93.4,92.5,85.8,84.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8IVH2-1","Forkhead box protein P4 [OS=Homo sapiens]",2,1,1,1,680,73.4,6.4,3.89,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","FOXP4","ENSG00000137166","","","",0.845,0.778,0.889,0.896,0.719,98.9,91,104,117,104.9,84.1,98.7,91.1,99.8,85.6,97.7,90.8,103.8,108.3,92,94.2,116.8,166.1,107.1,90.9,104.7,91.8,76.7,83.9,43.3,39.9,43.7,37.5,42.8,39.8,45.5,47.5,40.3,41.3,51.2,72.8,46.9,39.8,45.9,40.2,33.6,36.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q08379","Golgin subfamily A member 2 [OS=Homo sapiens]",25,17,41,17,1002,113,5.02,133.28,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","GOLGA2","ENSG00000167110","","COPI-mediated anterograde transport; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; COPII-mediated vesicle transport; Golgi Cisternae Pericentriolar Stack Reorganization","",0.847,0.817,0.818,0.823,0.826,99,95.5,95.6,117,96.2,96.6,100.2,100.2,97.5,96.7,92,97.7,93.1,96.8,102.2,106.5,118.4,118.4,97.4,91.3,97.4,101.1,97.7,95.5,3191.9,3192.7,3105,3078.4,2930.2,3112.2,2965.9,3081.9,3255.1,3392,3771,3769.6,3102,2907,3100.9,3219.7,3112.4,3043.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9P107","GEM-interacting protein [OS=Homo sapiens]",22,15,19,15,970,106.6,5.72,66.22,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus","enzyme regulator activity;other molecular function","GMIP","ENSG00000089639","","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle","",0.848,0.899,0.873,0.888,0.849,94.9,100.7,97.8,112,99.4,95,97.1,92.9,93.4,99.1,101.6,98.3,96.2,96.2,96.3,110.2,107.6,129.2,95.4,97.8,101.9,93.3,93.5,100.2,1099.7,1051.8,1057,1121.5,1149.8,1112.4,1089.1,1089.1,1089.6,1246.9,1218.1,1462.3,1079.9,1107.1,1153.3,1056.4,1058,1134.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8WUY9","DEP domain-containing protein 1B [OS=Homo sapiens]",4,2,2,2,529,61.7,8.85,4.37,"signal transduction;other biological processes","","enzyme regulator activity","DEPDC1B","ENSG00000035499","","RHOC GTPase cycle; RHOA GTPase cycle; RAC1 GTPase cycle; RHOB GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; CDC42 GTPase cycle; RHOG GTPase cycle; RAC3 GTPase cycle; RHOQ GTPase cycle; RAC2 GTPase cycle; RHOJ GTPase cycle; RND2 GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; RND1 GTPase cycle","",0.848,0.985,0.897,0.983,0.944,89.9,104.5,95.1,106.1,104.2,100.2,73,89.8,91.4,104.3,88.6,121.7,94.9,84.4,113.3,84,105.9,125.2,90.9,120.5,104,100,98.4,109.9,44.7,55,56,63.9,54.3,74.5,58.1,51.7,69.4,51.5,64.9,76.7,55.7,73.8,63.7,61.2,60.3,67.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P78318","Immunoglobulin-binding protein 1 [OS=Homo sapiens]",35,9,22,9,339,39.2,5.38,65.68,"signal transduction;other biological processes","cytosol;other cell component","enzyme regulator activity;other molecular function","IGBP1","ENSG00000089289","Autophagy; Autophagy","","16p11.2 proximal deletion syndrome",0.85,0.757,0.802,0.856,0.796,100.7,89.7,95.1,118.6,101.5,94.4,96.3,103.7,94.9,101.1,85.7,81.6,99.6,85.4,90.9,100.4,113.3,187.5,97,102,85.5,99.2,90.2,85.8,1841.8,1984,1815.8,1934.6,1640,1560.9,1905,1634.3,1739.2,1921.7,2167.9,3587.4,1855.4,1951.4,1635.1,1899.1,1726.1,1641.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P54105","Methylosome subunit pICln [OS=Homo sapiens]",35,5,13,5,237,26.2,4.11,50.27,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","","CLNS1A","ENSG00000074201","","snRNP Assembly","",0.851,0.769,0.776,0.835,0.801,101.5,91.7,92.5,119.2,99.6,95.5,101.3,91.2,99.7,90.1,88.5,90.6,93.1,90.9,89,108,117.2,171.2,95.4,97.9,99.8,93.9,94.7,87.4,576.6,519.1,567.9,513.2,503.9,516.1,530.2,517.6,506.9,615,667.2,974.6,543.1,557.2,568.1,534.5,539.4,497.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P49023","Paxillin [OS=Homo sapiens]",6,3,5,3,591,64.5,6.19,11.08,"cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","PXN","ENSG00000089159","Chemokine signaling pathway; VEGF signaling pathway; Focal adhesion; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection; Human cytomegalovirus infection; Human papillomavirus infection; Human immunodeficiency virus 1 infection; Viral carcinogenesis; Proteoglycans in cancer","VEGFA-VEGFR2 Pathway; GAB1 signalosome; Smooth Muscle Contraction; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; Localization of the PINCH-ILK-PARVIN complex to focal adhesions; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components","Integrin-mediated cell adhesion; Prolactin signaling pathway; Oncostatin M signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; 3q29 copy number variation syndrome; Regulation of actin cytoskeleton",0.852,0.836,0.828,0.831,0.847,98.4,96.6,95.7,115.5,96,97.9,102,105.4,98.6,100.7,100.1,93.8,103.3,99.1,97.3,119.7,120.8,52.1,103.2,99.4,95.2,99.7,101.4,108.2,568.8,588,550.2,561.5,558.4,523,576.4,552.9,542.8,667.6,673.9,290.4,575.8,554.7,531.3,556.2,565.5,603.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q92581-1","Sodium/hydrogen exchanger 6 [OS=Homo sapiens]",4,2,2,2,669,74.1,6.48,5.34,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity","SLC9A6","ENSG00000198689","Cardiac muscle contraction","Sodium/Proton exchangers; Defective SLC9A6 causes  X-linked, syndromic mental retardation,, Christianson type (MRXSCH)","",0.853,0.931,0.851,0.815,0.871,96.2,105,95.9,112.8,91.9,98.2,103.7,93,96.1,102.9,104.9,113.4,104.6,88.9,95.9,107,112.8,117,91.9,89.9,99.1,98.7,82,98.2,131.3,117.8,121.8,130.4,132.9,143.6,132.5,112.7,121.5,135.5,142.8,148.2,116.4,113.8,125.5,125,103.9,124.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q3B7T1","Erythroid differentiation-related factor 1 [OS=Homo sapiens]",6,7,7,7,1238,138.4,6.33,17.87,"other biological processes","nucleus","","EDRF1","ENSG00000107938","","","",0.853,0.829,0.838,0.833,0.852,98.4,95.5,96.6,115.3,96,98.2,94.9,99.2,97.7,94.9,90,99.7,94.8,98.5,95.9,109.4,114.5,141,98.9,94.1,95.3,86.1,97.8,97.5,562,588,578.8,562,533.3,590.7,561.8,583.4,568.1,648,678.3,835.2,585.8,557.5,564.7,510.4,579.4,577.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96JY6-1","PDZ and LIM domain protein 2 [OS=Homo sapiens]",12,3,3,3,352,37.4,8.72,6.42,"cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","PDLIM2","ENSG00000120913","","","",0.854,0.841,0.867,0.926,0.858,95.8,94.4,97.4,112.2,103.9,96.3,94.4,95.9,97.8,87,94.5,100.2,97.5,101.2,97,112.4,98.1,121.8,106.2,95.2,104,96.1,96.4,104.2,214,217.5,221.6,197.3,214.3,227.1,220.9,229.4,219.9,254.7,222.5,276.2,240.7,215.9,235.8,218,218.4,236.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P0C7T5","Ataxin-1-like [OS=Homo sapiens]",6,5,8,5,689,73.3,6.6,17.02,"cell organization and biogenesis;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","ATXN1L","ENSG00000224470","Notch signaling pathway; Spinocerebellar ataxia; Pathways of neurodegeneration","","",0.854,0.919,0.882,0.828,0.843,96.2,103.5,99.4,112.6,93.3,95,95.4,100.2,93.9,103.7,102.6,97.2,100.1,97.3,98.5,108,111.6,132.9,93.4,91.1,92.5,95.8,91.7,94.2,911.1,957.2,897.2,990.2,979.5,927.9,955.8,929.4,941,1031.5,1066.3,1269,892.5,869.8,883.4,914.6,876,899.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P30050-1","60S ribosomal protein L12 [OS=Homo sapiens]",61,9,44,9,165,17.8,9.42,146.63,"protein metabolism;other metabolic processes","cytosol;translational apparatus;nucleus;other cell component","nucleic acid binding activity;other molecular function","LOC100405643; LOC105608827; LOC111146158; RPL12","ENSAMEG00000016712; ENSAMEG00000029212; ENSBIXG00000003717; ENSBIXG00000023607; ENSBTAG00000006963; ENSBTAG00000025385; ENSCAFG00000020136; ENSCAFG00030009173; ENSCAFG00040018547; ENSCJAG00000000365; ENSCJAG00000018082; ENSFCAG00000010302; ENSG00000197958; ENSGGOG00000000648; ENSLCNG00005020821; ENSOCUG00000004902; ENSPPAG00000030541; ENSPTRG00000022808; ENSSBOG00000036154; ENSSSCG00000033019; ENSSSCG00070015049","Ribosome; Coronavirus disease","L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Formation of a pool of free 40S subunits; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins; Cytoplasmic ribosomal proteins",0.856,0.72,0.745,0.754,0.83,104.7,88.1,91.1,122.3,92.2,101.5,103,104.9,92.8,86.7,83.2,113.3,88.3,89.6,92.5,120.6,120.4,116.3,91,90.7,85.9,99.9,126.2,94.6,3601.4,3667.8,3244.8,3028.9,2909.5,3961,3086.6,3132.4,3234.7,4215.9,4207,4064.2,3179.1,3170.6,3003.6,3491.2,4412.6,3305.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NWH9-1","SAFB-like transcription modulator [OS=Homo sapiens]",29,32,68,32,1034,117.1,7.87,177.79,"other biological processes","nucleus","nucleic acid binding activity","SLTM","ENSG00000137776; ENSPTRG00000007121","","","",0.858,0.83,0.829,0.848,0.851,98.7,95.5,95.3,115,97.6,97.9,101.1,97.1,97.4,99.7,94.2,90.3,102.4,94.1,93.1,112.7,113.5,125.6,98.9,96.3,95.3,97.2,94.1,96.7,8738.5,8391.5,8417.2,8618.6,8144.8,7808.1,8850,8132.5,8050,9743.9,9812.7,10851.5,8549.3,8324.4,8235.3,8403.8,8136.9,8355.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q03468","DNA excision repair protein ERCC-6 [OS=Homo sapiens]",3,4,4,4,1493,168.3,8.09,11.65,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","ERCC6","ENSG00000225830","Nucleotide excision repair","Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; B-WICH complex positively regulates rRNA expression; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression","Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum",0.858,0.92,0.857,0.945,0.917,93.7,100.4,93.5,109.2,103.1,100.1,98.1,88,93.9,100.7,104.5,94.8,106.9,88.8,93.7,117.3,109.4,99.8,103.4,96.5,104.7,100.4,98.9,100.3,372.8,334.4,356.7,382.4,397,360.3,406.1,337.5,356.1,445.7,415.7,379,392.7,366.4,397.7,381.3,375.7,381,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y6I9","Testis-expressed protein 264 [OS=Homo sapiens]",52,11,32,11,313,34.2,4.86,102.42,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","TEX264","ENSG00000164081","","Platelet degranulation","",0.859,0.877,0.88,0.894,0.85,96.2,98.2,98.5,111.9,100,95.1,88.8,97.1,97.4,100.8,99.2,97.4,95.3,99.5,101.2,94.7,113,121.3,101,103.8,100.8,96.1,94.3,98.2,2411.4,2636,2643.9,2736.1,2692,2644.6,2587.7,2701.3,2748.2,2572,3068.2,3293,2742.7,2816.6,2737.8,2607.9,2561.2,2664.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8IWV8","E3 ubiquitin-protein ligase UBR2 [OS=Homo sapiens]",9,13,16,13,1755,200.4,6.24,47.01,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","UBR2","ENSG00000024048","","Antigen processing: Ubiquitination & Proteasome degradation","Male infertility",0.86,0.951,0.889,0.833,0.843,96,106.1,99.3,111.6,93,94.1,95.6,96.1,100.1,105,108.2,106.3,99.4,100.6,94,109.4,112.7,111.8,93.1,90.2,95.1,89.9,94.2,98.2,895.8,900.8,937.5,983.8,1014,995.9,931.5,942.6,880.6,1025.3,1056,1047.3,872.3,844.7,890.9,842.7,882.8,919.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O96028-1","Histone-lysine N-methyltransferase NSD2 [OS=Homo sapiens]",13,14,20,14,1365,152.2,8.69,51.59,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NSD2","ENSG00000109685","Lysine degradation; Metabolic pathways; Transcriptional misregulation in cancer","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; PKMTs methylate histone lysines; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)","",0.861,0.829,0.835,0.887,0.85,98.2,94.5,95.3,114,101.1,96.9,99.9,98.9,97.2,98.1,88.6,95.1,92.1,95.9,97.8,114.8,124.8,102.5,98.7,101.8,101.9,98.1,97.6,96,1212.7,1200.5,1180.3,1191.8,1076,1155.4,1118.9,1164.8,1187.8,1394.4,1516.1,1245.2,1199.2,1236.1,1237.6,1191.6,1185.3,1165.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P00395","Cytochrome c oxidase subunit 1 [OS=Homo sapiens]",2,1,2,1,513,57,6.7,6.58,"other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MT-CO1","ENSG00000198804","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Electron transport chain: OXPHOS system in mitochondria; Effects of nitric oxide; Nonalcoholic fatty liver disease; Neuroinflammation; Mitochondrial complex IV assembly",0.862,0.915,0.895,0.905,0.804,96.1,102.1,99.8,111.5,100.9,89.6,89.8,88.8,96.2,94.7,95.4,98.5,103.8,93.3,90.6,104.2,90.7,203.6,87.1,107.8,94.3,83.8,80.4,97.2,312,308.4,334.2,329.1,331.3,342.3,360.7,324,314.7,362,315,707.4,302.7,374.5,327.5,291,279.3,337.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NR12-1","PDZ and LIM domain protein 7 [OS=Homo sapiens]",1,1,1,1,457,49.8,8.41,1.64,"cell organization and biogenesis;transport;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","PDLIM7","ENSG00000196923","","RET signaling","Ebstein-Barr virus LMP1 signaling",0.863,1.013,0.939,0.886,0.949,91.6,107.5,99.7,106.2,94.1,100.8,89.2,96,82.8,96,123.7,104.7,97,104.9,93.2,103.4,75,180,82.6,91.6,94.5,88.9,98.2,98.2,94,101.1,87.3,101.1,130.4,110.3,102.3,110.6,98.2,109,79,189.7,87,96.6,99.6,93.6,103.5,103.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UPT8","Zinc finger CCCH domain-containing protein 4 [OS=Homo sapiens]",21,17,41,16,1303,140.2,6.27,107.27,"other biological processes","cytosol;nucleus","other molecular function","ZC3H4","ENSG00000130749","","","",0.864,0.821,0.846,0.801,0.793,101.2,96.1,99,117.1,93.8,92.8,103.5,101.1,102,90.5,97,102.5,100.4,99.8,91.9,114.6,118,131.5,97.1,80.8,94.6,93.6,94.6,86.4,2437.5,2379.5,2402.2,2130.6,2282.6,2412.4,2363.7,2350.7,2164.5,2696.8,2779.2,3096.9,2285.5,1902.4,2226.5,2204.1,2227,2034.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q92845","Kinesin-associated protein 3 [OS=Homo sapiens]",10,7,10,6,792,91.1,5.08,27.94,"cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","KIFAP3","ENSG00000075945","","COPI-dependent Golgi-to-ER retrograde traffic; Translocation of SLC2A4 (GLUT4) to the plasma membrane; MHC class II antigen presentation; Kinesins; Intraflagellar transport","Genes related to primary cilium development (based on CRISPR)",0.865,0.895,0.918,0.849,0.904,95.6,98.8,101.4,110.5,93.8,99.9,99.7,83.8,95.9,99.2,95.1,101,99,101.9,104.5,110.9,105.8,122.9,95.9,92.2,94.2,100.3,94.3,103.5,349.2,293.6,336.2,347.8,333.3,354.1,347,357,366.1,388.8,370.6,430.5,336.1,323.1,330,351.5,330.4,362.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UK97","F-box only protein 9 [OS=Homo sapiens]",9,3,3,3,447,52.3,6.15,9.57,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;other cell component","other molecular function","FBXO9","ENSG00000112146","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",0.866,0.928,0.941,0.927,0.92,93.1,99.7,101.2,107.5,99.7,98.9,96,84.1,88.6,95,107.1,92.7,96.9,96.3,84,102.4,96.2,198.7,97.3,93.3,94.9,85.3,97.2,94.1,264.9,232.1,244.5,262.1,295.5,255.9,267.5,265.9,231.7,282.5,265.3,548.2,268.4,257.4,261.9,235.5,268.3,259.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O95167","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [OS=Homo sapiens]",49,3,11,3,84,9.3,8.46,20.56,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity","NDUFA3","ENSG00000170906; ENSG00000273642; ENSG00000274359; ENSG00000275605; ENSG00000275724; ENSG00000276061; ENSG00000276220; ENSG00000276766; ENSG00000277722; ENSG00000278365","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",0.867,0.873,0.813,0.823,0.914,98.3,99,92.2,113.4,93.4,103.7,94,102.2,99.8,98.9,100.5,111.6,93.6,87.4,99.6,115.1,137.8,69.9,104.6,88.1,94.8,105.4,105.2,91.5,1018.7,1107.6,1081.9,1072,1089.5,1210.4,1014.4,947.9,1080.1,1248.2,1493.8,758,1133.8,955.2,1027.3,1143.2,1140.7,991.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P11277","Spectrin beta chain, erythrocytic [OS=Homo sapiens]",9,19,54,9,2137,246.3,5.27,150.96,"cell organization and biogenesis","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity","SPTB","ENSG00000070182","","COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins","",0.867,0.868,0.837,0.824,0.858,99,99.1,95.6,114.2,94.1,97.9,97.6,98.2,95.5,100.2,96.4,97.7,94.2,91.2,96.8,112.5,112.1,135.6,96.9,92.7,92.6,95.1,98.4,96.5,930.4,937,910.9,955.7,919,931.5,898.3,870.1,922.9,1072.7,1069,1293.3,924.3,883.9,882.7,907,938.4,920,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y5U2-1","Protein TSSC4 [OS=Homo sapiens]",13,4,9,4,329,34.3,5.19,23.79,"","","","TSSC4","ENSG00000184281","","","",0.868,0.963,0.889,0.931,0.849,94.7,105.1,96.9,109.1,101.6,92.6,91.3,90.8,98.6,105.8,101.3,95.7,92,94.6,93.5,101.6,105.2,169.5,97.9,92.9,99.8,91.5,88.9,89.3,697,693.3,752.9,807.7,773.4,730.6,702.7,722.3,713.6,775.7,803,1294,747.9,709.4,762,698.3,678.4,681.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q5TA45-1","Integrator complex subunit 11 [OS=Homo sapiens]",11,4,5,4,600,67.6,8.06,15.6,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","INTS11","ENSG00000127054","","RNA polymerase II transcribes snRNA genes","",0.869,0.943,0.929,0.898,0.904,94.1,102.1,100.6,108.2,97.1,97.9,91.9,88.4,91.5,99.3,96.2,101.2,97.8,92.7,98.8,105.2,101.8,165.7,92.3,101.5,94.4,95.2,98.2,88.1,404.9,389.2,402.9,437.2,423.7,445.6,430.6,408.3,435,463.4,448.5,729.7,406.6,446.8,415.9,419.1,432.6,388,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BRQ0","Pygopus homolog 2 [OS=Homo sapiens]",4,1,1,1,406,41.2,7.28,5.84,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","nucleus","enzyme regulator activity;other molecular function","PYGO2","ENSG00000163348","","Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex","1q21.1 copy number variation syndrome",0.87,0.795,0.87,0.912,0.818,99.2,90.5,99.2,114,103.9,93.3,101.6,121.9,97.1,92.8,92.1,113,101.6,92.2,102.3,116.8,125.9,40.5,104,107.5,106.5,95.6,97.4,91.2,76.7,91.9,73.2,70,69.5,85.2,76.6,69.6,77.2,88.1,95,30.5,78.4,81.1,80.3,72.1,73.4,68.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q16539-2","Isoform CSBP1 of Mitogen-activated protein kinase 14 [OS=Homo sapiens]",30,8,27,1,360,41.5,5.88,83.13,"","","","MAPK14","","","","",0.871,0.88,0.939,0.874,0.913,95.4,96.4,102.9,109.5,95.8,100,94.2,95.2,94.2,95.2,100.8,95.2,97.7,102,101.6,107.1,108.2,123.1,92.8,101.5,94.6,98.7,98.8,99.1,1589.9,1608,1590.9,1607.6,1701.2,1607.3,1648.6,1721.9,1715.7,1807.9,1826.4,2078.1,1567.2,1713.8,1597.2,1665.6,1667.8,1672.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8NDZ4","Deleted in autism protein 1 [OS=Homo sapiens]",3,1,1,1,430,49.5,8.53,3.64,"cell cycle OR cell proliferation;developmental processes;other biological processes","non-structural extracellular;other membranes;ER/Golgi","","DIPK2A","ENSG00000181744","","","",0.872,0.89,0.819,0.796,0.784,101.3,103.5,95.2,116.2,92.6,91.2,90,103.1,101.5,115.4,103.6,89.6,100.4,95.3,92.9,98.2,116.4,131.9,81.5,108.7,92.7,91.3,102.2,85.4,85.8,98.3,96.8,110.1,98.9,85.5,95.8,90.9,88.7,93.7,111,125.8,77.7,103.7,88.4,87.1,97.5,81.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96AQ6","Pre-B-cell leukemia transcription factor-interacting protein 1 [OS=Homo sapiens]",49,27,164,27,731,80.6,5.33,540.44,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","PBXIP1","ENSG00000163346","","","VEGFA-VEGFR2 signaling pathway",0.874,0.892,0.973,0.973,0.989,91.9,93.9,102.4,105.2,102.4,104.1,87,90.1,92,91.9,92.5,88.9,103.5,100.3,99.2,96.9,103.1,141.5,99.4,100.3,103.2,102,100.4,107.7,12984,13437.2,13734.2,13718.3,13795.2,13260.9,15448.4,14969.7,14807,14464.8,15380.5,21118.4,14837,14967.2,15402,15217,14976.6,16069.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UIL8","PHD finger protein 11 [OS=Homo sapiens]",3,1,1,1,331,37.6,7.72,0,"","other membranes;nucleus","other molecular function","PHF11","ENSG00000136147","","","",0.875,0.951,0.718,0.915,1.068,95,103.3,78,108.5,99.3,116,109.9,80,97,105.5,77.6,111.3,76.7,84.6,79.7,122.8,110.9,66.7,148.2,101.4,78.5,122.7,107.9,118.5,26,18.9,23,25,18.4,26.3,18.2,20,18.9,29.1,26.3,15.8,35.1,24,18.6,29.1,25.6,28.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8NFK1","Gap junction gamma-3 protein [OS=Homo sapiens]",2,1,2,1,279,31.3,9.17,3.57,"cell-cell signaling;transport;other biological processes","plasma membrane;other membranes","transporter activity","GJC3","ENSG00000176402","","","",0.875,0.942,0.914,0.824,0.891,96.4,103.8,100.7,110.2,90.8,98.2,98.4,98.1,90.9,94.3,105.6,105.7,90.7,102.4,110.6,112.1,90.8,112.9,92.4,88.6,105.3,99.3,99.9,101.9,191.4,191,176.9,183.5,205.5,205.7,176.4,199.3,215.2,218.1,176.8,219.7,179.7,172.5,205,193.2,194.4,198.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P54725-1","UV excision repair protein RAD23 homolog A [OS=Homo sapiens]",61,15,83,12,363,39.6,4.58,184.98,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","RAD23A","ENSG00000179262; ENSGGOG00000023403; ENSPTRG00000010552","Nucleotide excision repair; Protein processing in endoplasmic reticulum","Formation of Incision Complex in GG-NER; Josephin domain DUBs; DNA Damage Recognition in GG-NER","Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum",0.876,0.762,0.784,0.774,0.836,104.4,90.9,93.5,119.2,92.3,99.7,101.6,105,102.8,89,89.4,108.4,92,90.6,97,117.3,117.7,114.8,96.8,87,90.8,98.1,110.1,91.5,7076,7311.1,7154,6199.1,6224.5,7543.8,6404.3,6306.9,6753.9,8166.2,8196.6,7994.9,6739.2,6058.8,6323.1,6826.3,7666.6,6371.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q16563","Synaptophysin-like protein 1 [OS=Homo sapiens]",10,2,2,2,259,28.5,8.43,6.69,"cell-cell signaling","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","SYPL1","ENSG00000008282","","","",0.878,0.866,0.881,0.916,0.876,97.2,95.9,97.6,110.8,101.5,97,91.1,97.3,97.6,108,96,93.6,114.5,97.7,91,94.4,113.9,110.9,101.5,103.9,100.5,101.4,97.1,89.5,296.3,316.4,317.5,351.2,312.2,304.3,372.2,317.6,295.9,307,370.5,360.5,330.1,337.9,326.8,329.7,315.7,290.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q58WW2","DDB1- and CUL4-associated factor 6 [OS=Homo sapiens]",12,7,9,7,860,96.2,5.27,24.22,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","DCAF6","ENSG00000143164","","Neddylation","",0.878,0.902,0.881,0.887,0.838,97.8,100.5,98.2,111.4,98.8,93.3,105.8,100.4,98.1,103.2,104.4,98.9,90.4,100.8,105.4,115.1,114.4,69.2,101.4,97.9,101.6,95.8,95.1,102.1,808.5,766.9,749.5,788.4,797.7,755.5,690.6,770.1,805.3,879.3,873.7,528.9,774.8,748.1,776.2,731.8,726.7,780.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NT62","ubiquitin-like-conjugating enzyme ATG3 [OS=Homo sapiens]",49,10,43,10,314,35.8,4.74,144.69,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;other cell component","other molecular function","ATG3","ENSG00000144848","Autophagy; Autophagy; Kaposi sarcoma-associated herpesvirus infection","Macroautophagy","Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Senescence and autophagy in cancer",0.879,0.879,0.849,0.874,0.862,98.7,98.7,95.3,112.3,98.2,96.8,99.9,100,96.4,99.9,101.4,97.5,95.2,96.4,97.5,114.3,113.6,95.1,99.3,100.1,98.7,96.9,97.9,99.9,4893.7,4902.8,4723.8,4894.8,4970.4,4776.7,4666.9,4725.1,4778.2,5600.4,5566.6,4661.3,4866.8,4905.8,4838.5,4749,4796.8,4893.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UMS0","NFU1 iron-sulfur cluster scaffold homolog, mitochondrial [OS=Homo sapiens]",15,3,8,3,254,28.4,5.07,17.9,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytosol;mitochondrion;nucleus","other molecular function","NFU1","ENSG00000169599","","","",0.88,0.796,0.85,0.766,0.842,102.8,93,99.4,116.9,89.5,98.4,102.8,107.6,97.6,89.1,93,98.9,99.4,81.8,99.4,107.3,116.9,129.2,95.3,89.5,88.8,94.1,110.8,98.4,956,1001.1,907.9,828.7,864.9,919.6,924.2,761.1,924.6,998.1,1086.8,1201.9,886.4,832.4,825.9,874.9,1030.4,915.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["A2RU67","Protein FAM234B [OS=Homo sapiens]",6,3,6,3,622,67,5.02,18.88,"","other membranes;cytoskeleton;ER/Golgi","","FAM234B","ENSG00000084444","","","",0.88,0.891,0.881,0.947,0.926,95.6,96.7,95.7,108.6,102.8,100.6,91.2,95.3,94.4,95.5,95.6,92.7,91.2,96.5,94.5,106.8,107.2,139.3,102.1,101.5,100,94.1,99.3,102.9,404.9,423.1,418.8,423.8,424.3,411.4,404.6,428.2,419.2,474,475.7,618.1,452.9,450.6,443.9,417.5,440.6,456.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8TCG1","Protein CIP2A [OS=Homo sapiens]",17,16,20,16,905,102.1,6.23,51.54,"","plasma membrane;other membranes;cytosol;other cell component","other molecular function","CIP2A","ENSG00000163507","","","Netrin-UNC5B signaling pathway",0.881,0.937,0.887,0.917,0.917,95.4,101.5,96.1,108.3,99.3,99.3,97.6,95.6,92,95.9,106.6,101.7,96.2,96.7,95.7,108.5,104.2,119.8,99.6,93,99.5,99.5,99.5,98.5,2423.3,2372.3,2284,2382,2647.5,2524.4,2388,2399.5,2374.8,2692.9,2587.1,2974.8,2473.8,2308,2469.1,2470.8,2469,2446.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q02383","Semenogelin-2 [OS=Homo sapiens]",1,1,2,1,582,65.4,9.07,4.54,"stress response;other biological processes","non-structural extracellular","other molecular function","SEMG2","ENSG00000124157","","","Genotoxicity pathway",0.882,1.018,1.018,0.899,1.006,90.9,104.9,104.9,103,92.6,103.6,89.2,92.9,83.2,94.9,102.9,122,100.6,102.9,103.3,101.1,96.9,137.3,90.8,95.8,83.9,102.9,97.9,101.6,333.4,347.5,311,354.9,384.8,456.2,376,384.8,386.2,377.9,362.2,513.4,339.6,358.3,313.8,384.9,366.2,380,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8IUH4","Palmitoyltransferase ZDHHC13 [OS=Homo sapiens]",6,3,8,2,622,70.8,8.07,22.22,"protein metabolism;other metabolic processes;transport","other membranes;ER/Golgi","transporter activity;other molecular function","ZDHHC13","ENSG00000177054","","","",0.883,0.921,0.937,0.926,0.963,94.1,98.2,99.9,106.6,98.7,102.6,91.7,94.1,95.4,93.8,100.3,98.2,97.3,99.8,100.6,106.3,106.6,116.2,100.7,95.2,98.7,98.1,102.6,104.5,395.9,406.3,411.9,405,433.2,423.8,420.3,431.1,434.2,458.9,460.1,501.9,434.9,411,426.2,423.4,443.1,451.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q49AR2-1","UPF0489 protein C5orf22 [OS=Homo sapiens]",36,8,19,8,442,49.9,4.78,74.54,"","","","C5orf22; FLJ11193","ENSG00000082213","","","",0.884,0.886,0.837,0.795,0.804,101.9,102.1,96.4,115.3,91.6,92.7,94.3,103.2,105.5,103.5,104.1,102.4,98.3,97.7,94.2,109.5,118.3,116.8,92.3,92.9,92.8,86.4,94.1,93.9,815.1,892.1,911.7,894.4,899.7,884.9,850.2,844.5,814.6,946.5,1022.8,1009.5,797.6,802.7,802.7,747,813.7,811.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9ULR3","Protein phosphatase 1H [OS=Homo sapiens]",3,1,1,1,514,56.4,6.6,0,"protein metabolism;other metabolic processes","nucleus;other cell component","other molecular function","PPM1H","ENSG00000111110","","","",0.885,1.011,0.897,1.046,1.003,90.9,103.9,92.1,102.7,107.4,103,83.6,90.9,94.3,125.4,87.3,103.9,86.3,92.1,122,102.7,52.4,153.8,114.2,82.3,107.4,107.3,103,91.2,12.8,13.9,14.4,19.1,13.3,15.9,13.2,14.1,18.6,15.7,8,23.5,17.4,12.6,16.4,16.4,15.7,13.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9P2S5","WD repeat-containing protein WRAP73 [OS=Homo sapiens]",3,1,1,1,460,51.6,6.81,3.02,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;other cell component","","WRAP73","ENSG00000116213","","","",0.885,0.906,1.009,0.888,0.872,95.5,97.8,108.9,107.9,95.8,94.1,95.1,90.3,101.9,127.1,90.4,97.3,85.4,108.4,108.4,88.7,107.4,119.1,117.1,94.5,95.3,95.6,84.3,93.7,213.6,203,228.9,285.6,203.2,218.7,192,243.6,243.5,199.3,241.3,267.6,263.1,212.4,214.2,214.9,189.5,210.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P23588","eukaryotic translation initiation factor 4B [OS=Homo sapiens]",57,37,190,37,611,69.1,5.73,559.29,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","translation activity;nucleic acid binding activity","EIF4B","ENSG00000063046","mTOR signaling pathway; PI3K-Akt signaling pathway; Proteoglycans in cancer","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Deadenylation of mRNA; mTORC1-mediated signalling","Translation factors; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Malignant pleural mesothelioma; Interferon type I signaling pathways",0.887,0.866,0.87,0.882,0.823,99.9,97.5,98,112.6,99.4,92.7,96.9,97.8,98.8,95.5,96.2,89.3,99.3,96,91.3,107.3,110.3,161.8,97.3,91.4,97.3,93.7,89.2,90.7,24075.2,24282.4,24547.3,23707.3,23883.5,22185.8,24658.2,23830.8,22675.1,26651.7,27388.3,40191.1,24166.4,22689.4,24172.7,23270.2,22146.1,22532.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NUE0","Palmitoyltransferase ZDHHC18 [OS=Homo sapiens]",7,2,2,2,388,42,9.04,5.22,"protein metabolism;other metabolic processes;transport","other membranes;ER/Golgi","other molecular function","ZDHHC18","ENSG00000204160","","","",0.887,0.89,0.774,0.817,0.956,100,100.3,87.2,112.7,92.1,107.7,91.1,99.4,113.8,84.3,99.7,102.7,81,90.7,86.7,110.8,112,140.5,91.5,90.8,94.8,90.5,112.8,107.1,101.4,110.6,126.7,93.9,111,114.3,90.2,101,96.5,123.4,124.7,156.5,101.9,101.1,105.5,100.8,125.6,119.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6P9G4","Transmembrane protein 154 [OS=Homo sapiens]",30,3,8,3,183,20.5,4.53,18.12,"","other membranes","","TMEM154","ENSG00000170006","","","",0.888,0.937,0.828,0.879,0.872,98.6,104,92,111,97.6,96.8,95.5,102.7,99.7,110.1,87.5,105.2,89.5,93.4,93,100.3,118.7,112.3,102.4,98.8,94,98,106,92.9,246.1,264.5,256.9,283.7,225.4,271.1,230.5,240.6,239.7,258.5,305.7,289.4,263.9,254.5,242,252.4,273,239.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NVR2","Integrator complex subunit 10 [OS=Homo sapiens]",8,6,8,6,710,82.2,7.44,17.12,"RNA metabolism OR transcription;other metabolic processes","nucleus","","INTS10","ENSG00000104613","","RNA polymerase II transcribes snRNA genes","",0.889,0.898,0.944,0.934,0.959,94.8,95.8,100.7,106.7,99.7,102.3,94.6,96,104.3,100,89.3,97,102,100.8,109.4,108,110.9,75.2,100.9,102,96.7,103,103.6,106.2,729.8,741.2,805,771.6,689.4,748.7,787.4,777.7,844.1,833.7,856.1,580.1,779,787.5,746,795.3,799.8,819.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6PJW8","Consortin [OS=Homo sapiens]",13,8,14,8,725,79.5,4.53,33.56,"other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","CNST","ENSG00000162852","","","",0.889,0.897,0.872,0.82,0.793,101.2,102.1,99.2,113.8,93.4,90.3,88.8,98,98.8,102.2,98.8,97.5,99.1,96,90.3,101.9,110.2,183.8,90.4,91.3,89,87.3,89.3,87.3,818.2,903.3,910.4,941.9,910.7,898.5,913.6,885.1,832.7,939.6,1015.5,1694.6,832.9,841.5,820.6,805.1,822.7,805.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q08378","Golgin subfamily A member 3 [OS=Homo sapiens]",27,31,49,31,1498,167.3,5.44,179.93,"other biological processes","other membranes;cytosol;ER/Golgi;nucleus","","GOLGA3","ENSG00000090615","","RND2 GTPase cycle","",0.89,0.879,0.894,0.892,0.906,97.8,96.6,98.2,109.9,98,99.5,94.5,96.8,97.9,95.8,94.5,95.5,96.9,97.1,102.7,104.5,108.7,134,97,93.2,97.1,99.2,98.5,96.1,3741.6,3832.4,3878.2,3792.3,3740.3,3782.8,3837.9,3846.2,4066.1,4138.6,4304.2,5305.8,3839.5,3690.1,3845.2,3925.9,3898.8,3804,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q969X1","Protein lifeguard 3 [OS=Homo sapiens]",5,2,5,2,311,34.6,7.72,12.28,"other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding","TMBIM1","ENSG00000135926","","Neutrophil degranulation","",0.892,1.009,0.924,0.97,0.868,94.5,106.9,97.9,105.9,102.7,92,83.6,86.7,91.1,95.5,106.5,98.1,89.9,81.9,92.3,96,97.2,241.9,94.3,97.2,90.5,90.1,84.4,82.8,436.1,452.2,475.2,498,555.3,511.8,468.9,427.1,481.4,500.6,507.2,1261.5,491.8,507,472,470,440.4,431.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8N6T7-1","NAD-dependent protein deacetylase sirtuin-6 [OS=Homo sapiens]",14,5,10,5,355,39.1,9.19,24.69,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","other molecular function","SIRT6","ENSG00000077463","Nicotinate and nicotinamide metabolism; Metabolic pathways; Thermogenesis; Central carbon metabolism in cancer","Pre-NOTCH Transcription and Translation; Processing of DNA double-strand break ends","SREBF and miR33 in cholesterol and lipid homeostasis; NAD+ metabolism; NAD+ biosynthetic pathways; Thermogenesis; Thyroid hormones production and peripheral downstream signaling effects",0.892,0.886,0.889,0.89,0.883,98.4,97.7,98.1,110.3,98.1,97.4,100.4,96.8,97.6,101.5,96.9,94.3,97.3,96,104,109.2,110,109.4,100.8,97.4,97,96.5,96.6,98.1,808,778.3,785.5,816.9,779.8,758.6,783,772.3,836.6,878.8,884.7,880.3,811.3,783.2,780.4,776.2,777.4,789.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P25098","Beta-adrenergic receptor kinase 1 [OS=Homo sapiens]",35,22,59,22,689,79.5,7.28,168.04,"cell-cell signaling;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","GRK2","ENSG00000173020","Chemokine signaling pathway; Endocytosis; Hedgehog signaling pathway; Glutamatergic synapse; Olfactory transduction; Morphine addiction","Cargo recognition for clathrin-mediated endocytosis; G alpha (q) signalling events; Activation of SMO; G alpha (s) signalling events; Calmodulin induced events","Chemokine signaling pathway; Hedgehog signaling pathway; Hedgehog signaling pathway Netpath",0.893,0.931,0.881,0.905,0.917,96.9,101,95.7,108.6,98.2,99.5,97,96.6,98.6,96.9,105.8,101.1,98.5,95.7,95.7,108.6,100.8,109.5,99.7,97,98.3,101.7,99.6,99.1,5770.3,5748.1,5867.6,5763.7,6296.8,6014.8,5860,5695.7,5694.1,6462.3,5998.2,6519.3,5933.5,5771.7,5847.9,6053,5925.2,5897.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8WVX9","Fatty acyl-CoA reductase 1 [OS=Homo sapiens]",28,11,46,11,515,59.3,9.17,131,"other metabolic processes","other membranes;other cytoplasmic organelle;other cell component","other molecular function","FAR1","ENSG00000197601","Peroxisome","Wax biosynthesis","",0.894,0.925,0.887,0.933,0.886,97.1,100.5,96.4,108.6,101.3,96.2,95.1,99.1,97.3,95.6,100.7,101,96.6,95.2,97,108.6,109.6,108.8,101.1,101.5,104,96.4,99.1,93.1,4154.9,4330.4,4250.3,4178.8,4398.7,4414.4,4219,4160.3,4238.3,4744.6,4787.8,4754.8,4417.5,4436.3,4542.4,4211.4,4331.7,4069.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q12874","splicing factor 3a subunit 3 [OS=Homo sapiens]",32,18,78,18,501,58.8,5.38,267.18,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","SF3A3","ENSG00000183431","Spliceosome","mRNA Splicing - Major Pathway","Exercise-induced circadian regulation; mRNA processing",0.895,0.857,0.855,0.862,0.878,100.4,96.2,96,112.2,96.7,98.6,102.5,100.8,101.7,97.4,100.1,96.6,99.4,97.1,97.2,113.7,116.6,82,101.3,98,97,100.3,99.8,98.4,10049.4,9881.4,9965,9546.2,9807.5,9464,9737.6,9520.7,9525.6,11139.1,11431.4,8039.3,9931.1,9603.7,9501.6,9830.7,9784.2,9648,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q14676","Mediator of DNA damage checkpoint protein 1 [OS=Homo sapiens]",30,36,90,36,2089,226.5,5.47,351.3,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction","nucleus;other cell component","other molecular function","MDC1","ENSG00000137337; ENSG00000206481; ENSG00000224587; ENSG00000225589; ENSG00000228575; ENSG00000231135; ENSG00000234012; ENSG00000237095","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Nonhomologous End-Joining (NHEJ); Processing of DNA double-strand break ends; TP53 Regulates Transcription of DNA Repair Genes; SUMOylation of DNA damage response and repair proteins; G2/M DNA damage checkpoint","ATM signaling in development and disease ; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome",0.896,0.869,0.859,0.878,0.855,100.4,97.3,96.2,112,98.3,95.8,99.5,97.6,100.2,95.4,97.3,96.5,96.1,95.4,94.5,102.1,111,140,97.5,95.6,97.4,93.4,94.9,95.5,6055.4,5942.3,6100.8,5805.5,5921.1,5873,5851,5806.4,5754,6218.4,6758.8,8526.2,5938.6,5821.5,5930.9,5685.5,5779.7,5817,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q86UK7-1","E3 ubiquitin-protein ligase ZNF598 [OS=Homo sapiens]",22,18,37,18,904,98.6,8.4,97.4,"protein metabolism;other metabolic processes","","translation activity;other molecular function","ZNF598","","","","",0.896,0.878,0.861,0.856,0.835,101,98.9,96.9,112.6,96.4,94.1,103.5,98.8,101.2,98.8,99.2,99.5,97.2,97.5,92.9,115.3,113,111.3,99.2,93.2,96.7,95,93.5,94.4,3258.7,3109.5,3187.1,3109.3,3122.9,3132,3060.6,3067.7,2923.2,3628.8,3556,3502.6,3122,2933.4,3044.2,2992,2942.3,2970.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UJ68-1","Mitochondrial peptide methionine sulfoxide reductase [OS=Homo sapiens]",26,6,20,6,235,26.1,8.09,51.01,"protein metabolism;other metabolic processes;stress response","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","other molecular function","MSRA","ENSG00000175806; ENSG00000285250","","Protein repair","Sulindac metabolic pathway; Methionine de novo and salvage pathway",0.897,0.897,0.906,0.959,0.947,96,96,97,107,102.6,101.3,98,94.5,94.8,94.8,98.3,93.2,99.5,94.5,95.7,105.6,96.3,134.6,101.3,102.3,97.5,100,101.3,97.6,1882,1814,1819.7,1819.6,1886.6,1788.6,1909.4,1814.7,1837.6,2027.9,1848.3,2583.9,1944.7,1963.4,1871.7,1919.5,1945.1,1873.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8N4Q1","Mitochondrial intermembrane space import and assembly protein 40 [OS=Homo sapiens]",40,8,22,8,142,16,4.31,56.66,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","mitochondrion","other molecular function","CHCHD4","ENSG00000163528","","Mitochondrial protein import","",0.898,0.931,1.036,1.082,0.935,91.6,95,105.7,102,110.4,95.4,87,89.8,111.6,105.4,93.2,87.7,103.6,109.2,102.7,100.1,98.2,107,108.3,102,109.3,103.1,93.6,88.3,2229.1,2301.6,2861.1,2699.8,2388,2248.6,2655.9,2798.5,2631,2564.4,2515.7,2742.8,2774.9,2614,2800,2640.9,2398.4,2262,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["A6NK58","Putative lipoyltransferase 2, mitochondrial [OS=Homo sapiens]",4,1,1,1,231,25.2,8.27,2.54,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","other molecular function","LIPT2","ENSG00000175536","Lipoic acid metabolism; Metabolic pathways; Biosynthesis of cofactors","Glyoxylate metabolism and glycine degradation","",0.899,0.911,0.99,0.809,0.858,98.6,99.9,108.7,109.7,88.8,94.2,84.1,92.1,92.5,93.4,91.3,94.4,100.3,101.5,106.5,96,102.5,241.7,76.9,82.9,85.5,81.6,88,88.6,69.1,75.7,76,76.7,75,77.6,82.4,83.4,87.5,78.9,84.2,198.5,63.1,68.1,70.3,67.1,72.3,72.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q68CR1-1","Protein sel-1 homolog 3 [OS=Homo sapiens]",3,3,3,3,1132,128.5,7.28,6.59,"","other membranes;nucleus","","SEL1L3","ENSG00000091490","","","",0.9,0.906,0.932,0.911,0.96,96.2,97,99.7,107,97.4,102.7,87.9,94,102.3,91.1,102,94.8,96.8,97.4,104.6,103.1,104.5,130,90.2,109.9,95.2,102,100.3,93.8,206.8,221.3,240.8,214.4,239.9,223,227.7,229.2,246,242.6,246,306,212.3,258.6,224,240.1,236.1,220.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P31483","nucleolysin TIA-1 isoform p40 [OS=Homo sapiens]",27,10,33,7,386,42.9,7.74,86.3,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","TIA1","ENSG00000116001","","FGFR2 alternative splicing","",0.9,0.907,0.907,0.894,0.906,98,98.7,98.7,108.8,97.3,98.6,91.2,96.9,98.5,99.4,94.9,97.6,93.7,97.6,102.3,102.3,107.6,133.3,95.3,99.9,96.2,97.5,98.7,96.9,3900.9,4145.5,4214.5,4253.9,4057.6,4175.1,4007,4175.3,4375,4378,4604.4,5702.7,4077.5,4273.1,4116.1,4172.7,4223.8,4144.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q5JPI3","Uncharacterized protein C3orf38 [OS=Homo sapiens]",16,4,7,4,329,37.5,6.47,16.73,"other biological processes","nucleus","","C3orf38","ENSG00000179021","","","",0.901,0.951,0.939,0.885,0.862,97.6,103.1,101.7,108.3,95.9,93.4,99.7,97.4,101.7,105.1,105.2,105.4,92.4,103.8,107.6,114.6,110.6,80,97.9,95.3,100.6,91.6,95.7,95.3,765.5,747.6,781.1,806.9,808.1,809.1,709.5,797.3,826.2,880.3,849.5,614.1,752,732,772.3,703.3,734.6,732.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P23258","tubulin gamma-1 chain [OS=Homo sapiens]",62,18,48,6,451,51.1,6.14,209.17,"cell cycle OR cell proliferation;cell organization and biogenesis","cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","TUBG1","ENSG00000131462","Human papillomavirus infection","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",0.901,0.888,0.89,0.91,0.878,98.9,97.4,97.7,109.7,99.8,96.4,99.2,94.7,98.1,101,96.5,92.9,102.2,96.8,95.3,107.6,108.8,117.2,98.9,106.4,98.1,93.8,95.5,96.9,2799.5,2673.5,2767,2850,2724.5,2620.6,2882.8,2732.7,2688.4,3036.3,3069.6,3308.7,2792.1,3002.6,2768.8,2647.2,2695.7,2735.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q86W56","Poly(ADP-ribose) glycohydrolase [OS=Homo sapiens]",17,12,21,12,976,111,6.43,67.22,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","PARG","ENSG00000227345","","POLB-Dependent Long Patch Base Excision Repair","",0.903,0.911,0.962,0.94,0.912,96.3,97.1,102.5,106.6,100.2,97.2,98.2,96.3,95.3,97.2,98.9,97.2,102.5,104.2,100.6,106.6,108.2,102.5,100.3,96,101.3,97.2,95.5,102,1132.5,1110.4,1099.3,1120.4,1139.8,1120.1,1182.2,1201.7,1159.4,1229.4,1247.5,1182.3,1156.1,1107,1167.5,1121.1,1100.6,1176,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q7Z6M1-1","Rab9 effector protein with Kelch motifs [OS=Homo sapiens]",19,6,8,6,372,40.5,6.25,20.97,"transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","","RABEPK","ENSG00000136933","","Retrograde transport at the Trans-Golgi-Network","",0.904,0.867,0.855,0.921,0.833,100.8,96.7,95.4,111.5,102.7,92.9,97.6,100.6,102.8,96.6,101.5,87.8,98.2,95.2,93.8,101.1,111.4,127.4,104.3,96.8,102.6,88.9,92.8,100.6,730.7,753.6,770.1,723,760,657.7,735.2,713,702.5,756.7,834,954.1,780.7,725.1,768.2,665.8,694.7,753.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96HW7","integrator complex subunit 4 [OS=Homo sapiens]",20,13,23,13,963,108.1,6.44,66.67,"RNA metabolism OR transcription;other metabolic processes","nucleus","","INTS4","ENSG00000149262","","RNA polymerase II transcribes snRNA genes","",0.905,0.926,0.934,0.955,0.967,95.4,97.7,98.5,105.5,100.8,102,97.8,95.6,92.8,98.2,97.9,95.7,101.9,97.5,98.7,105.7,105.7,104.5,101,101,99,102.2,98.4,106.4,1414,1382.1,1341.7,1419.5,1415.3,1382.8,1473.3,1409.8,1426.8,1527.7,1528.1,1510.2,1459.6,1460.5,1430.8,1477.4,1422.8,1538,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H0Q0","Protein FAM49A [OS=Homo sapiens]",24,6,11,3,323,37.3,6.01,28.97,"cell organization and biogenesis","other membranes","other molecular function","CYRIA","ENSG00000197872","","","",0.906,0.972,0.936,0.945,0.925,95.6,102.6,98.8,105.6,99.7,97.7,91.4,106.1,97.3,105.6,104.5,101.4,100.6,93.9,105.6,107.6,107.4,71.3,98.2,110,101.5,106.6,99.4,91.5,125.4,145.7,133.6,144.9,143.4,139.3,138.1,128.9,144.9,147.8,147.5,97.9,134.9,151,139.3,146.3,136.5,125.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8WU39-1","Marginal zone B- and B1-cell-specific protein [OS=Homo sapiens]",77,13,131,13,189,20.7,5.57,553.33,"cell organization and biogenesis;other biological processes","non-structural extracellular;ER/Golgi;other cell component","","MZB1","ENSG00000170476","","","",0.906,0.917,1.03,1.035,0.982,92.6,93.7,105.3,102.2,105.8,100.4,89.3,88.6,99.7,103.2,90.3,87.7,107,101.4,95.7,93.4,98.5,149.6,101,103.9,102,98.2,96.8,93.6,8775.8,8713.1,9807.6,10149.9,8881.9,8619.4,10525.6,9974.3,9408.9,9180.9,9686.2,14707.4,9929.6,10220.6,10026,9659.6,9513.1,9206.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P61927","60S ribosomal protein L37 [OS=Homo sapiens]",45,7,32,7,97,11.1,11.74,64.25,"protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","RPL37","ENSG00000145592","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis","Cytoplasmic ribosomal proteins",0.907,0.87,0.861,0.931,0.853,100.3,96.3,95.2,110.7,103.1,94.4,90.8,99.3,102.3,102.8,95.3,86.7,106.3,94.2,89.9,99.2,109.5,137.3,104,102,92.8,102.2,93.4,91.9,7300.4,7981.5,8223.9,8262,7660.5,6972.6,8548.4,7576.5,7229.7,7977.3,8804.4,11039.9,8361.1,8199.1,7462.4,8218.5,7512,7389,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y4R8","telomere length regulation protein TEL2 homolog [OS=Homo sapiens]",16,9,19,9,837,91.7,5.76,60.21,"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TELO2","ENSG00000100726","Fanconi anemia pathway; mTOR signaling pathway","","Fragile X syndrome; Malignant pleural mesothelioma",0.908,0.958,0.965,0.95,0.99,94.4,99.6,100.4,104,98.8,102.9,91.6,93.4,96.1,96.2,98.5,100.8,96.8,99.8,99.3,102.9,101.7,122.9,101,95.7,97.8,101.9,99.3,104.2,776.6,792.2,815.5,816.3,835.8,855,821.3,846.6,842.5,872.8,862.6,1042.5,856.9,811.4,829.2,864.2,842.7,883.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8WXF1","Paraspeckle component 1 [OS=Homo sapiens]",38,19,68,18,523,58.7,6.67,177.47,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity","PSPC1","ENSG00000121390","","","",0.909,0.885,0.883,0.889,0.909,99.6,97,96.7,109.6,97.4,99.6,97,99.1,101.6,94.9,96.8,96.5,96.3,95.4,97.6,106.4,109,122.1,97.6,96.8,97,99.6,97.2,99.1,8249.9,8431.3,8643.9,8070.9,8231.1,8209.1,8187.2,8112.7,8300.1,9046.3,9273.6,10387.9,8299.7,8233.4,8247.4,8471.5,8268.2,8431.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8WU79-1","Stromal membrane-associated protein 2 [OS=Homo sapiens]",19,9,18,9,429,46.8,8.87,45.43,"","other cell component","enzyme regulator activity;other molecular function","SMAP2","ENSG00000084070; ENSGGOG00000004018; ENSPTRG00000000589","Endocytosis","","",0.91,0.964,0.929,0.891,0.903,97.6,103.3,99.6,107.2,95.5,96.8,98.7,96.3,100.8,104.5,99.1,106.3,96.7,100.8,104.3,108.5,111.5,90,96.6,93.7,99.6,94.9,99.9,97.9,3209.2,3132.5,3278.3,3398.4,3220.8,3456.5,3142.7,3275.7,3390.1,3527,3625.2,2925.9,3140.9,3045,3237.7,3084.8,3246.9,3184.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P46379-1","Large proline-rich protein BAG6 [OS=Homo sapiens]",24,23,92,23,1132,119.3,5.6,264.05,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;translation activity;other molecular function","BAG6","ENSG00000096155; ENSG00000204463; ENSG00000227761; ENSG00000228760; ENSG00000229524; ENSG00000233348; ENSG00000234651","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",0.911,0.914,0.897,0.886,0.869,99.8,100.2,98.2,109.6,97,95.2,97.6,95.8,98.3,98.4,98.1,94.4,96.2,96.7,95.2,107.2,106.5,143.9,95,94.6,98.6,93.1,93.2,97.3,7524.9,7383,7578.1,7581.1,7556.4,7276.2,7410.1,7450.5,7335.4,8263,8205.4,11091.5,7319.1,7287.2,7600.7,7175.8,7182.3,7499.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P38435-1","vitamin K-dependent gamma-carboxylase [OS=Homo sapiens]",1,1,1,1,758,87.5,8.02,2.41,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","other molecular function","GGCX","ENSG00000115486","Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways; Biosynthesis of cofactors","Gamma-carboxylation of protein precursors; Defective gamma-carboxylation of F9","",0.911,1.04,1.039,0.988,1.041,90.8,103.7,103.6,99.7,98.4,103.7,91.4,90.5,91,87,107.8,103.8,105.8,99.1,103.7,99.8,86.4,114.9,90.3,102.7,98.6,100,103.9,123.3,84.5,83.6,84.1,80.4,99.6,95.9,97.7,91.6,95.9,92.2,79.8,106.2,83.4,94.9,91.1,92.4,96,113.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q14CX7-1","N-alpha-acetyltransferase 25, NatB auxiliary subunit [OS=Homo sapiens]",15,13,22,13,972,112.2,6.64,61.2,"protein metabolism;other metabolic processes","cytosol;ER/Golgi;other cell component","","NAA25","ENSG00000111300","","","",0.912,0.955,0.899,0.954,0.909,97.2,101.8,95.9,106.6,101.7,96.9,98.6,96.3,95.2,100.8,102.5,100.3,100.9,94.1,95,110.1,105.6,102.7,95.6,100.7,107.4,96,93.2,104.8,1685.2,1645.8,1626.7,1722.9,1751.8,1714.7,1723.5,1608,1622.8,1881.7,1804.4,1754.6,1634.4,1721.2,1836.1,1640.2,1593.2,1790.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q15111-1","Inactive phospholipase C-like protein 1 [OS=Homo sapiens]",4,3,3,3,1095,122.6,5.62,5.54,"cell-cell signaling;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","PLCL1","ENSG00000115896","GABAergic synapse","","GPR40 pathway",0.913,0.917,0.957,0.871,0.878,99,99.3,103.8,108.4,94.4,95.2,87.4,99.1,98.2,88.5,98.6,124.8,103,112,85,107.6,85.6,127.8,91.3,105.3,93.7,89.1,94.5,108.6,43.8,49.6,49.2,44.4,49.4,62.6,51.6,56.1,42.6,53.9,42.9,64,45.7,52.8,47,44.7,47.4,54.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q13404","Ubiquitin-conjugating enzyme E2 variant 1 [OS=Homo sapiens]",44,6,37,3,147,16.5,7.93,105.51,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","","UBE2V1","ENSG00000244687","Ether lipid metabolism; Metabolic pathways; Shigellosis","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; CLEC7A (Dectin-1) signaling; Aggrephagy; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; activated TAK1 mediates p38 MAPK activation; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling","IL-1 signaling pathway; Interleukin-1 induced activation of NF-kB; MYD88 distinct input-output pathway",0.914,0.857,0.823,0.816,0.914,103,96.6,92.8,112.7,92,103,98.1,100.2,100.2,93.9,88.5,108.1,90.2,90.9,89.4,109.6,104.6,147,97.3,88.9,89.4,100.2,114.2,89.4,3070.1,3137.6,3135,2939.1,2769.6,3382.8,2823.2,2845.7,2799.5,3429.5,3274.3,4600.9,3045.3,2784.2,2799.7,3135.2,3574.5,2798.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P61289-1","Proteasome activator complex subunit 3 [OS=Homo sapiens]",67,15,105,15,254,29.5,5.95,358.87,"cell cycle OR cell proliferation;protein metabolism;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","HEL-S-283; LOC101359250; LOC103001388; LOC111151323; LOC111166421; Psme3; PSME3","ENSBTAG00000019918; ENSCAFG00000014716; ENSCATG00000043580; ENSCCAG00000025926; ENSCGRG00001014333; ENSCGRG00015000348; ENSECAG00000012620; ENSG00000131467; ENSGGOG00000010707; ENSLAFG00000013446; ENSMLUG00000004084; ENSMMUG00000012685; ENSMNEG00000003232; ENSMPUG00000010027; ENSMUSG00000078652; ENSNVIG00000013505; ENSOARG00000003731; ENSOGAG00000009420; ENSPPAG00000043945; ENSPTRG00000009225; ENSPTRG00000049975; ENSRBIG00000001980; ENSRNOG00000051344; ENSSBOG00000024784; ENSSSCG00000017385; ENSSSCG00005010026; ENSSSCG00015075406; ENSSSCG00025054060; ENSSSCG00030072129; ENSSSCG00035013193; ENSSSCG00040025703; ENSSSCG00045007466; ENSSSCG00050060716; ENSSSCG00055025037; ENSSSCG00060042579; ENSSSCG00065003129; ENSSSCG00070012475; ENSSSUG00005017981; ENSSTOG00000028833; ENSTSYG00000002969; ENSUAMG00000013177; ENSUMAG00000025062","Proteasome; Antigen processing and presentation; Hepatitis C","Degradation of DVL; Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; Downstream TCR signaling; FCERI mediated NF-kB activation; Neddylation; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog 'on' state; Ub-specific processing proteases; Regulation of RUNX3 expression and activity; Antigen processing: Ubiquitination & Proteasome degradation; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; The role of GTSE1 in G2/M progression after G2 checkpoint; MAPK6/MAPK4 signaling; UCH proteinases; Regulation of PTEN stability and activity; ABC-family proteins mediated transport; Regulation of RAS by GAPs; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of ornithine decarboxylase (ODC); Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF(Skp2)-mediated degradation of p27/p21; Degradation of beta-catenin by the destruction complex; Autodegradation of the E3 ubiquitin ligase COP1; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of DVL; Hedgehog ligand biogenesis; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Interleukin-1 signaling; FCERI mediated NF-kB activation; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Neddylation; Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases; UCH proteinases; ABC-family proteins mediated transport; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Hedgehog ligand biogenesis; Degradation of beta-catenin by the destruction complex; Downstream TCR signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; MAPK6/MAPK4 signaling; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; Regulation of RUNX2 expression and activity; Regulation of RUNX3 expression and activity; Regulation of PTEN stability and activity; Interleukin-1 signaling; Regulation of RAS by GAPs; Autodegradation of the E3 ubiquitin ligase COP1; Neddylation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; SCF(Skp2)-mediated degradation of p27/p21; Degradation of beta-catenin by the destruction complex; Separation of Sister Chromatids; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; NIK-->noncanonical NF-kB signaling; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX3 expression and activity; Regulation of PTEN stability and activity; Antigen processing: Ubiquitination & Proteasome degradation","Proteasome degradation; Proteasome degradation; Proteasome degradation; Proteasome degradation",0.915,0.903,0.865,0.851,0.885,101.3,100,95.8,110.7,94.2,98,104,104.5,101.6,99.5,102.7,103.1,93.2,98.4,102,117.8,113.7,67.8,97.8,96.6,96.8,98.1,100.6,101.6,9690.9,9738.7,9461.6,9272.6,9569.7,9602.3,8683.4,9165.5,9503.9,10968.7,10594.5,6311.9,9114.4,9002.1,9015.7,9140.9,9372.2,9462.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P32780","General transcription factor IIH subunit 1 [OS=Homo sapiens]",13,4,6,4,548,62,8.66,15.18,"protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","nucleus","other molecular function","GTF2H1","ENSG00000110768; ENSG00000288114","Basal transcription factors; Nucleotide excision repair; Viral carcinogenesis","NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER","Eukaryotic transcription initiation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum",0.915,0.966,0.964,0.837,0.886,98.6,104.1,103.8,107.8,90.2,95.5,88,88.2,95.5,82.4,106.9,93.1,92.8,101.9,90.8,96.4,86.8,280.8,80.7,76.3,90.5,77.9,85.8,85.4,232.8,233.2,252.7,217.9,282.7,246.2,245.6,269.5,240.2,254.9,229.6,742.9,213.5,201.7,239.4,206,226.9,225.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P19447","TFIIH basal transcription factor complex helicase XPB subunit [OS=Homo sapiens]",11,7,17,7,782,89.2,7.23,49.11,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ERCC3","ENSG00000163161","Basal transcription factors; Nucleotide excision repair","Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER","Eukaryotic transcription initiation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum",0.916,0.916,0.933,0.945,0.931,97.4,97.4,99.2,106.3,100.5,99.1,96,94.6,94.8,93.7,94.8,95.3,100.6,96.6,96.1,102.8,103.5,151.2,97.9,97.9,97.2,93,96.4,97.6,1329.1,1309.9,1312.7,1297.7,1312.9,1318.8,1393.3,1337.1,1330,1422.5,1433,2093.6,1355.1,1354.7,1345.8,1287.5,1334.7,1351.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UNZ2-4","Isoform 2 of NSFL1 cofactor p47 [OS=Homo sapiens]",64,22,118,1,339,37.3,5.11,367.84,"","","","NSFL1C","","","","",0.917,0.885,0.83,0.898,0.838,102.5,98.9,92.8,111.8,100.4,93.7,106.4,96.4,103.1,99.5,107.1,97.4,93.3,91.1,96.6,116.3,112.4,93.6,101,101,98.9,94.2,94.2,97.5,1181.9,1070.2,1144.8,1104.8,1189.6,1081.9,1035.9,1011.4,1072.2,1291.8,1248.3,1039.2,1121.1,1121,1098.5,1045.4,1046.2,1082.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NUL7","Probable ATP-dependent RNA helicase DDX28 [OS=Homo sapiens]",15,8,13,8,540,59.5,10.42,42.01,"cell organization and biogenesis","cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","DDX28","ENSG00000182810","","","",0.918,0.916,0.865,0.925,0.873,100.2,100,94.4,109.2,101,95.3,97.7,95.7,94.7,97.7,95.5,93.4,90.2,89.8,96.1,101.9,104.3,180.3,94.5,96.5,98.2,91,87.8,95,1559.3,1526.7,1510.9,1558.4,1524,1490.7,1439.3,1432.9,1533.1,1625.5,1663.8,2877.1,1508.7,1539.3,1566.5,1452.1,1401.7,1515.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P50750","Cyclin-dependent kinase 9 [OS=Homo sapiens]",22,6,25,5,372,42.8,8.79,76.73,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;kinase activity;other molecular function","CDK9","ENSG00000136807","Transcriptional misregulation in cancer","Estrogen-dependent gene expression; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; RNA polymerase II transcribes snRNA genes; Interactions of Tat with host cellular proteins","MicroRNAs in cardiomyocyte hypertrophy; IL-9 signaling pathway; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; Male infertility",0.919,0.922,0.871,0.889,0.875,100.7,101.1,95.5,109.6,97.4,95.9,98.6,94.8,101.2,98.9,107.8,98.9,97.9,93.4,90,101.6,107.3,145.8,94,95.3,96.9,94.1,89.7,93.8,1682.1,1617.4,1727.3,1688.2,1840.6,1688.3,1671,1594.7,1536.2,1734.4,1830.8,2488.3,1603.6,1626.7,1653.5,1605.2,1531.2,1601.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q15361","Transcription termination factor 1 [OS=Homo sapiens]",6,4,5,4,905,103,9.38,14.5,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus","nucleic acid binding activity;other molecular function","TTF1","ENSG00000125482","Thyroid hormone synthesis","NoRC negatively regulates rRNA expression; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Transcription Termination; Surfactant metabolism","Thyroid stimulating hormone (TSH) signaling pathway; Thyroid hormones production and peripheral downstream signaling effects",0.919,0.883,0.912,0.904,0.925,99.5,95.6,98.7,108.2,97.8,100.1,101.5,103.4,96.2,97,97.5,97.6,101,100.7,100.2,114.6,110.4,64.6,109.8,97.4,99.8,107.1,99.1,102.1,265.6,270.4,251.8,253.8,255.2,255.4,264.2,263.4,262.3,299.9,288.9,169.1,287.3,254.8,261.1,280.2,259.2,267.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P08047","Transcription factor Sp1 [OS=Homo sapiens]",7,5,12,4,785,80.6,7.34,37.41,"stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SP1","ENSG00000185591","Endocrine resistance; Mitophagy; TGF-beta signaling pathway; Estrogen signaling pathway; Cortisol synthesis and secretion; Parathyroid hormone synthesis, secretion and action; Cushing syndrome; Huntington disease; Spinocerebellar ataxia; Human cytomegalovirus infection; Pathways in cancer; Transcriptional misregulation in cancer; Breast cancer; Choline metabolism in cancer; Diabetic cardiomyopathy","PPARA activates gene expression; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Oncogene Induced Senescence; Activation of gene expression by SREBF (SREBP)","Androgen receptor signaling pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Integrated breast cancer pathway; Leptin signaling pathway; IL-17 signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Constitutive androstane receptor pathway; Estrogen receptor pathway; Nuclear receptors meta-pathway; Myometrial relaxation and contraction pathways; Copper homeostasis; Initiation of transcription and translation elongation at the HIV-1 LTR; MECP2 and associated Rett syndrome; TGF-beta signaling pathway; Mitochondrial gene expression; Oxidative stress response; Breast cancer pathway; Ethanol metabolism production of ROS by CYP2E1; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Gastrin signaling pathway; IL-18 signaling pathway; Angiotensin II receptor type 1 pathway; Malignant pleural mesothelioma; CCL18 signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways; Estrogen signaling pathway",0.92,0.93,0.891,0.91,0.907,99.3,100.4,96.2,108,98.2,97.9,94.8,105.2,99.3,100.4,96.8,101.2,97.4,96.1,96.2,107,111.8,107.9,97.7,98.2,99.9,97.9,93.4,98.7,838.2,930.9,878.4,888,856.4,895.3,861.5,850.5,850.9,946.7,988.7,954.8,864.4,868.7,883.5,865.8,826.3,873.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O00291","Huntingtin-interacting protein 1 [OS=Homo sapiens]",4,3,3,2,1037,116.1,5.3,7.67,"cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","HIP1","ENSG00000127946","Huntington disease; Pathways of neurodegeneration","Clathrin-mediated endocytosis; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants","",0.921,0.958,0.882,0.969,0.935,97.5,101.5,93.4,105.9,102.7,99,95.2,94.9,91.7,113.6,98.8,89,88,91,98.8,103.1,99.9,154.5,89,100.2,100,95.7,96.4,100.2,87.2,87,84,104.1,90.6,81.5,80.6,83.3,90.5,94.5,91.5,141.6,81.6,91.8,91.6,87.7,88.3,91.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q7L099-3","Isoform 3 of Protein RUFY3 [OS=Homo sapiens]",20,11,24,4,620,70.6,5.72,74.11,"","","","RUFY3","","","","",0.922,0.948,0.975,0.923,0.945,96.8,99.5,102.4,105,96.9,99.3,96.6,98,97,99.8,94,99.8,94.7,102.7,106,103.7,114,105.3,100.9,93,97.2,99.6,98.3,99.5,1295,1313.3,1301.2,1338.1,1260,1337.9,1269.2,1376.9,1421.6,1390.8,1528.2,1411.8,1353.2,1246.5,1302.6,1335.1,1318.4,1334.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9HCE0-1","Ectopic P granules protein 5 homolog [OS=Homo sapiens]",6,10,18,10,2579,292.3,6.43,52.57,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","other cytoplasmic organelle;other cell component","","EPG5","ENSG00000152223","","","",0.923,0.938,0.861,0.839,0.809,103.1,104.8,96.2,111.7,93.8,90.4,102.9,95.6,104.9,104.7,109.1,97.9,104.2,96.1,92,110.3,111.6,116.9,96.8,93.6,92.4,92.9,87.9,90.3,1086.3,1008.5,1106.7,1104.6,1151.9,1033.2,1100,1013.9,971.3,1164.7,1177.4,1234,1021.9,988.2,975,980.6,927.4,952.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q4KMQ1","Taperin [OS=Homo sapiens]",12,4,4,4,711,75.5,7.25,13.69,"cell organization and biogenesis;developmental processes;other biological processes","other cell component","other molecular function","TPRN","ENSG00000176058","","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea","",0.923,0.991,1.029,1.059,0.996,92.4,99.2,102.9,100,105.9,99.6,90.7,106.4,91,97.7,109.8,95.6,95.4,101.4,102.6,97.6,109.8,98.5,112.6,91.5,104.3,94.9,98.1,102.1,264,309.7,264.7,284.2,319.5,278.3,277.6,295,298.5,283.9,319.4,286.7,327.7,266.4,303.5,276.3,285.4,297,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y2B1","UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase [OS=Homo sapiens]",3,1,1,1,443,51.1,8.32,3.85,"protein metabolism;other metabolic processes","plasma membrane;other membranes;ER/Golgi;nucleus","other molecular function","RXYLT1","ENSG00000118600","Mannose type O-glycan biosynthesis; Metabolic pathways","","",0.923,0.92,1.032,0.919,0.855,98.1,97.7,109.6,106.2,97.6,90.8,97.5,107,93.4,100.2,97.1,75.8,109.7,108.9,88.2,88.7,105.5,163.4,97,104.1,94.2,101.5,77.6,90.2,51.2,56.2,49.1,52.7,51,39.8,57.6,57.2,46.3,46.6,55.5,85.9,51,54.7,49.5,53.3,40.8,47.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q13526","peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [OS=Homo sapiens]",50,6,25,6,163,18.2,8.82,92.95,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","cytoskeletal activity;other molecular function","PIN1","ENSG00000127445","RIG-I-like receptor signaling pathway","Regulation of TP53 Activity through Phosphorylation; RHO GTPases Activate NADPH Oxidases; ISG15 antiviral mechanism; Negative regulators of DDX58/IFIH1 signaling; PI5P Regulates TP53 Acetylation","Novel intracellular components of RIG-I-like receptor (RLR) pathway",0.925,0.889,0.916,0.959,0.908,99.1,95.3,98.2,107.2,102.8,97.3,94.5,97.7,99,105.5,90.1,93.9,102.8,96.8,94.3,93.2,105.7,130.8,101.4,105.8,98.5,96,98.3,95.8,2300.7,2380.3,2410.2,2569.4,2194.4,2288,2504.2,2357.5,2296.1,2270.6,2574.4,3185.4,2469.4,2576.9,2398.5,2337.3,2395.2,2332.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q14919-1","Dr1-associated corepressor [OS=Homo sapiens]",37,6,12,6,205,22.3,5.17,20.18,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","DRAP1","ENSG00000175550; ENSPTRG00000003903","","Signaling by NODAL; Signaling by Activin","",0.926,0.797,0.794,0.766,0.834,108.5,93.5,93.1,117.3,89.8,97.8,106.7,113.3,98.6,91.9,91.8,109,95.8,84.3,91.5,115.2,125.1,96,96.3,88.3,87.1,96.1,117,96.1,877.6,932.5,810.9,756,755.1,896.9,788.1,693.6,752.7,948.2,1029.1,790.3,792.5,726.3,716.8,790.9,962.9,790.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q02083","N-acylethanolamine-hydrolyzing acid amidase [OS=Homo sapiens]",8,3,3,3,359,40,8.75,4.28,"other metabolic processes","other membranes;other cytoplasmic organelle;other cell component","other molecular function","NAAA","ENSG00000138744","","Neurotransmitter release cycle","",0.926,0.881,0.942,0.979,0.871,99.3,94.4,101,107.2,104.9,93.3,101.1,104.2,100.5,101.9,96.2,87,91.8,105.8,102.9,109.2,118,75.7,111,94.6,106.8,94.1,104.2,95,342.1,352.6,340,344.9,325.4,294.2,310.6,358,348,369.3,399.4,256.3,375.7,320.3,361.5,318.3,352.5,321.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q7Z7K0","COX assembly mitochondrial protein homolog [OS=Homo sapiens]",9,1,1,1,106,12.5,8.63,0,"","mitochondrion","other molecular function","CMC1","ENSG00000187118","","","Mitochondrial complex IV assembly",0.927,1.098,1.013,1.07,0.966,91.5,108.5,100,98.8,105.7,95.5,40.9,42.6,50,51.2,50.5,36.8,37.1,53.2,46.6,39.7,46,1032,54.5,35.9,49.2,43.1,44.4,46.4,74.1,77.3,90.6,92.8,91.5,66.6,67.2,96.4,84.4,72,83.4,1870.6,98.8,65,89.2,78.2,80.6,84.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q53F19","Nuclear cap-binding protein subunit 3 [OS=Homo sapiens]",25,11,20,11,620,70.5,5.73,51.06,"RNA metabolism OR transcription;other metabolic processes;stress response;transport","nucleus;other cell component","nucleic acid binding activity","NCBP3","ENSG00000074356","","","",0.928,0.939,0.859,0.898,0.824,102.2,103.5,94.6,110.1,98.9,90.7,94.1,92.3,95.1,95.3,90.8,96.2,85.5,87.1,88.6,101.4,100,253.7,91.1,88.2,92.3,80.3,84.6,83.5,1987.5,1949.7,2008.4,2012.5,1918.5,2032.8,1805.4,1839.4,1871.4,2142.3,2112.5,5358.8,1924.1,1863.8,1950.2,1697.4,1787.3,1765,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8NFQ8","Torsin-1A-interacting protein 2 [OS=Homo sapiens]",31,10,22,9,470,51.2,4.96,76.5,"cell organization and biogenesis;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","TOR1AIP2","ENSG00000169905","","","",0.928,0.966,0.946,0.844,0.838,100.8,105,102.7,108.6,91.7,91.1,102.4,104.9,102.2,103.1,106.7,109.2,99.1,106.5,104.4,110.4,111.1,80.4,91.9,93.2,97.4,93.4,91.1,92.6,1791.9,1834.1,1788,1802.7,1866.1,1909.7,1733.7,1862.1,1826.1,1931.1,1943.5,1406.5,1608.2,1630.4,1703.2,1634.4,1592.6,1619.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BXI6","TBC1 domain family member 10A [OS=Homo sapiens]",11,4,8,4,508,57.1,8.44,22.11,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;other cell component","enzyme regulator activity;other molecular function","TBC1D10A","ENSG00000099992","","TBC/RABGAPs","Deregulation of Rab and Rab effector genes in bladder cancer",0.929,1.012,0.942,0.927,0.898,97.6,106.4,99,105.1,97.4,94.4,91.1,94.4,93.2,106.4,93.9,101.5,94.1,94.5,107.9,94.5,100.3,179.2,93,96,90.7,90.1,88.3,91,914.7,947.5,935.3,1067.8,942.9,1018.9,944.1,948.3,1082.7,949,1007,1798.6,933.2,963.9,910.5,904.2,886.8,913,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O15160","DNA-directed RNA polymerases I and III subunit RPAC1 [OS=Homo sapiens]",37,9,25,9,346,39.2,5.5,78.2,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR1C","ENSG00000171453","RNA polymerase; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","Pyrimidine metabolism; Cytosolic DNA-sensing pathway",0.929,0.918,0.922,0.944,0.934,98.7,97.5,98,106.2,100.3,99.2,98.4,98.9,96.7,94.2,98.1,97.2,97.4,97.7,100.7,101.8,105.9,119.6,96.6,99.9,101.2,98.8,97.6,99.3,1486.1,1493.7,1460.5,1423.5,1481.2,1468.3,1471.1,1475.3,1520.5,1537.9,1599.4,1806.7,1459.4,1509.7,1529.2,1493.1,1474.2,1499.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q15116","Programmed cell death protein 1 [OS=Homo sapiens]",3,1,2,1,288,31.6,8.02,1.91,"developmental processes;other biological processes","plasma membrane;other membranes","","PDCD1","ENSG00000188389; ENSG00000276977","Cell adhesion molecules; T cell receptor signaling pathway; PD-L1 expression and PD-1 checkpoint pathway in cancer","Potential therapeutics for SARS; PD-1 signaling","T cell receptor and co-stimulatory signaling; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Interactions between immune cells and microRNAs in tumor microenvironment; Cancer immunotherapy by PD-1 blockade",0.93,0.888,0.948,1,0.839,99.5,95.1,101.5,107.1,107,89.8,102.8,90.5,100.8,107,96.3,88.3,109.3,102.8,95.1,108.4,130.1,69.1,89.1,108.4,121.5,101.6,90.9,88.1,51.5,45.3,50.5,53.6,48.2,44.2,54.7,51.5,47.6,54.3,65.1,34.6,44.6,54.3,60.8,50.9,45.5,44.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q15427","Splicing factor 3b subunit 4 [OS=Homo sapiens]",18,6,24,6,424,44.4,8.56,70.19,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","SF3B4","ENSG00000143368","Spliceosome","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","mRNA processing",0.93,0.881,0.838,0.917,0.846,103.1,97.7,92.9,110.8,101.6,93.8,101.7,96.2,101.9,92.6,96.4,98,93.7,90.7,91.7,109.4,105.4,147.9,94.8,102.6,100.3,91.3,92.6,92.9,2923,2764.4,2927.1,2659.1,2768.8,2815.1,2692.6,2604.5,2634.5,3142.1,3026.7,4250,2723.5,2948.1,2881.2,2624.3,2659.5,2668.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9P0V9","septin-10 [OS=Homo sapiens]",15,4,11,3,454,52.6,6.8,45.16,"cell cycle OR cell proliferation;other biological processes","cytoskeleton;other cell component","other molecular function","SEPTIN10","ENSG00000186522","","","",0.932,1.047,0.908,0.898,0.914,98.1,110.3,95.6,105.3,94.5,96.2,98.3,100.6,104.8,113,116.5,104.9,96.8,105.1,98,108,108.6,61,96.9,92.5,101.9,99,98.6,95.6,432.8,442.7,461.2,497.7,512.7,461.8,426.3,462.6,431.6,475.3,478.1,268.5,426.7,407.3,448.7,435.7,434.3,420.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6ZS17","RHO family-interacting cell polarization regulator 1 [OS=Homo sapiens]",4,4,4,4,1223,132.2,6.28,9.55,"stress response;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","RIPOR1","ENSG00000039523","","","",0.932,0.977,0.984,0.982,0.975,95.6,100.2,100.9,102.6,100.8,100,89.9,97.6,95.1,99.7,99.6,103.8,93.7,102.4,100.4,98.1,102.1,127.2,100.9,92,100.3,99.5,97.2,100.5,552.7,600.2,585,613.3,612.6,638.6,576.6,630.2,617.6,603.6,627.7,782.4,620.7,566,616.7,612.1,598,618.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96EW2-1","HSPB1-associated protein 1 [OS=Homo sapiens]",3,2,2,2,488,55.1,5.6,3.96,"","other cell component","other molecular function","HSPBAP1","ENSG00000169087","","","",0.932,0.893,0.89,0.886,0.867,102.3,98,97.7,109.7,97.2,95.1,106.8,106.5,99.9,102,101.9,107.7,94,101.6,103.2,118.7,114.2,46.8,94.4,101.2,103.2,93.7,99,105.2,226.9,226.2,212.3,216.7,216.6,228.9,199.8,216,219.2,252.1,242.6,99.5,200.5,215,219.3,199.1,210.3,223.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H825-1","Methyltransferase-like protein 8 [OS=Homo sapiens]",5,1,1,1,291,33.4,6.95,0,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","other molecular function","METTL8","ENSG00000123600","","","",0.933,0.861,0.942,0.935,0.748,103.3,95.4,104.3,110.7,103.5,82.8,94.1,73.1,153.2,86.9,82.2,116.2,84.2,95,110,100.8,77.1,167.6,89.1,94.3,139.8,74,87,75.4,17.8,13.9,29.1,16.5,15.6,22,16,18,20.9,19.1,14.6,31.8,16.9,17.9,26.5,14,16.5,14.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9ULT0-1","tetratricopeptide repeat protein 7A [OS=Homo sapiens]",11,10,18,10,858,96.1,6.46,52.77,"other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","","TTC7A","ENSG00000068724","","","",0.934,0.952,0.979,0.94,0.935,97.6,99.5,102.4,104.5,98.2,97.8,93.6,95.6,93.5,97.7,95.4,95,98.2,97.3,99.3,97.2,100.3,172.9,94.2,94.8,94.1,93.3,93.7,93.9,2405.2,2457.3,2403.4,2510.1,2451.8,2441.4,2523.5,2500,2552.2,2498.4,2576.4,4442.2,2420.9,2437.1,2417.2,2398.1,2409,2413.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P37802","Transgelin-2 [OS=Homo sapiens]",61,10,43,10,199,22.4,8.25,135.23,"other biological processes","non-structural extracellular;cytosol","","TAGLN2","ENSG00000158710","","Platelet degranulation","",0.934,0.829,0.864,0.849,0.907,104.2,92.4,96.3,111.5,94.6,101.1,102.3,102.1,96.6,90.5,83.1,115.3,90.4,94.4,95.1,102.2,109.2,123.9,94.6,89,92.7,99,125.8,93.8,4048.6,4040.5,3821.8,3582.3,3288.1,4562.8,3579.1,3735.4,3765.7,4046.3,4323.7,4904.2,3746.2,3520.9,3669.5,3920.3,4978.7,3711,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H6A0-1","DENN domain-containing protein 2D [OS=Homo sapiens]",5,2,3,2,471,53.6,7.64,9.16,"","cytosol;nucleus","enzyme regulator activity","DENND2D","ENSG00000162777; ENSPPAG00000037282","","RAB GEFs exchange GTP for GDP on RABs","",0.935,0.947,1.013,0.945,0.999,96.1,97.3,104.1,102.7,97.1,102.7,89.6,83.6,90.8,89.6,95.6,90.7,88.9,101.8,97.1,95.6,95.8,213.8,90.5,99.5,89.8,95.7,92.3,99.3,109.1,101.7,110.5,109.1,116.4,110.4,108.2,123.9,118.1,116.3,116.6,260.3,110.2,121.1,109.3,116.5,112.3,120.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q12904-1","aminoacyl tRNA synthase complex-interacting multifunctional protein 1 [OS=Homo sapiens]",48,13,71,12,312,34.3,8.43,230.84,"cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","AIMP1","ENSG00000164022","","Selenoamino acid metabolism; Cytosolic tRNA aminoacylation","Ciliary landscape",0.936,0.899,0.896,0.891,0.912,101.5,97.5,97.1,108.4,96.6,98.9,101.7,101.1,101.2,99.9,97.2,95.8,96.8,98.2,96,106.5,111.8,108.1,96.3,98.7,94.6,98.6,98,99.7,6997,6951.9,6960,6870.9,6688.6,6590.8,6660.2,6753.8,6603.1,7326.5,7692.8,7436.3,6625.8,6789.5,6504.9,6781.7,6743.7,6856.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y6E0","Serine/threonine-protein kinase 24 [OS=Homo sapiens]",44,16,82,9,443,49.3,5.69,238.94,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","STK24","ENSG00000102572","","Apoptotic cleavage of cellular proteins","",0.937,0.94,0.911,0.923,0.876,100.6,100.9,97.8,107.4,99.2,94.1,102.5,97.1,98.9,98.1,103.6,99.2,97.8,96.1,95.1,105.5,99.1,132.2,95.6,100.8,97.4,92.1,92.4,96.4,4003.2,3793.1,3860.6,3831.2,4046.8,3872.8,3819.6,3753,3714.6,4121.6,3869.7,5162.4,3734.8,3936.4,3805.8,3595.8,3610.4,3766.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NRN7","L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase [OS=Homo sapiens]",33,11,23,11,309,35.8,6.8,65.74,"protein metabolism;other metabolic processes","cytosol","other molecular function","AASDHPPT","ENSG00000149313","Pantothenate and CoA biosynthesis; Metabolic pathways","Vitamin B5 (pantothenate) metabolism","",0.937,0.952,0.935,0.945,0.904,99.1,100.7,98.9,105.7,100,95.6,100.9,99.6,99.6,104.8,101.2,97.6,99.4,97,101.8,108.8,106.3,91.7,100.5,104.3,97.3,96,94.5,98.9,2362.3,2330.3,2330.4,2451.8,2368.2,2283.4,2326.3,2270.9,2383.8,2546.7,2486.9,2147.2,2351.4,2441.5,2276.5,2247.6,2210.9,2314.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q969X6","U3 small nucleolar RNA-associated protein 4 homolog [OS=Homo sapiens]",8,6,11,6,686,76.8,8.85,25.28,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","UTP4","ENSG00000141076; ENSG00000262788","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",0.938,0.913,0.926,0.937,0.954,99.3,96.7,98,105.9,99.2,101,99.6,90.4,99.2,96.5,95.2,98.8,96.1,100.5,97.9,103.3,105.7,117.7,99,98.7,100.9,97.3,102.6,100.8,1113.1,1010,1108.2,1078.6,1064.2,1103.9,1074.5,1122.9,1093.6,1154.1,1180.9,1315.6,1106.4,1102.7,1127.2,1087.9,1146.4,1126.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y3D9","28S ribosomal protein S23, mitochondrial [OS=Homo sapiens]",19,4,5,4,190,21.8,8.9,13.39,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus","other molecular function","MRPS23","ENSG00000181610","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",0.939,0.904,0.865,0.914,0.932,101.4,97.6,93.5,108,98.7,100.7,111.6,104.5,100.8,100.6,91,105.1,96.3,101.4,96.3,111.3,111.4,46.9,101.7,102.6,93.3,103.8,120,101.4,992.4,929,896.1,894.5,809,934.3,856.4,901.8,855.9,989.6,990.3,417.1,904,912.6,830,922.6,1066.7,901.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P50914","60S ribosomal protein L14 [OS=Homo sapiens]",29,6,40,6,215,23.4,10.93,109.32,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","other molecular function","RPL14","ENSG00000188846","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",0.94,0.92,0.901,0.899,0.92,101.1,98.9,96.9,107.5,96.6,98.9,99.4,101.4,99.5,97.4,89.7,101.3,95.5,93.3,99,105.9,105.7,132.4,99.9,95.2,89.4,97.5,103.4,94,4896.5,4997.3,4903.8,4799.1,4419.9,4989.5,4702,4598,4875.1,5218,5207.7,6522.8,4922.4,4689.2,4402.6,4800.6,5094.7,4631.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96DU3-1","SLAM family member 6 [OS=Homo sapiens]",5,2,2,2,332,37.3,6.79,1.75,"stress response;developmental processes;other biological processes","plasma membrane;other membranes","","SLAMF6","ENSG00000162739","","Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell","",0.94,1.029,1.023,0.974,0.922,95.8,104.9,104.3,101.9,99.3,93.9,94.8,97.8,95.7,104.7,109.8,93.1,98.4,104.1,105.2,97.3,101.8,117.9,99.1,97.6,101,93.8,97.2,90.6,289,298.4,291.9,319.5,334.9,283.8,300.3,317.7,320.9,296.9,310.4,359.7,302.4,297.6,308,286.2,296.6,276.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q06546","GA-binding protein alpha chain [OS=Homo sapiens]",33,10,24,10,454,51.3,4.97,91.41,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","GABPA","ENSG00000154727","","Transcriptional activation of mitochondrial biogenesis","Energy metabolism; Allograft Rejection; Myometrial relaxation and contraction pathways; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Mitochondrial gene expression; Malignant pleural mesothelioma",0.941,0.946,0.905,0.922,0.898,100.6,101.1,96.8,106.9,98.5,96,101.2,102.3,99.1,106.5,101.8,99.8,95.4,99.9,97.4,110.6,107.6,90,99.2,100.4,96.1,94.5,101.2,96.7,2143.7,2166.7,2097.9,2255.3,2155.6,2113.4,2020.8,2115.5,2062.7,2342.3,2278.7,1906.4,2100.4,2124.9,2035.7,2001.2,2142.6,2047.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BU61-1","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [OS=Homo sapiens]",38,5,23,5,184,20.3,8.22,88.46,"cell organization and biogenesis","other membranes;mitochondrion;nucleus","","NDUFAF3","ENSG00000178057","Thermogenesis","Complex I biogenesis","",0.941,0.891,0.818,0.872,0.901,104.2,98.6,90.5,110.6,96.5,99.6,105.7,103.8,99.7,96,98.3,101.9,91.4,90.2,89.4,110.3,98.4,119.2,100.6,96,96.2,99.3,104.7,99.1,1924.6,1890.6,1815.1,1748.4,1789.3,1856.1,1663.5,1643.1,1627.5,2008,1792.1,2170.4,1831.8,1747.3,1751.2,1808.7,1905.8,1805.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q14004-2","Isoform 2 of Cyclin-dependent kinase 13 [OS=Homo sapiens]",11,13,20,11,1452,158.3,9.7,46.26,"","","","CDK13","","","","",0.942,0.972,0.887,0.886,0.86,101.9,105.1,95.9,108.2,95.9,93,103.2,96.6,101.8,103.4,105,106,95.8,101.2,94,108.1,105.1,112,95.8,90.9,100.6,92.9,90.2,97.4,1697.2,1587.9,1673,1700.6,1726.2,1742.2,1575.8,1663.4,1545.7,1776.7,1728.7,1841.4,1574.5,1494.4,1654,1527.8,1482.8,1602,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9P000-1","COMM domain-containing protein 9 [OS=Homo sapiens]",40,5,19,5,198,21.8,5.88,60.19,"transport;other biological processes","non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component","","COMMD9","ENSG00000110442","","Neutrophil degranulation; Neddylation","",0.943,0.941,0.973,0.981,0.966,97.4,97.3,100.6,103.4,101.4,99.9,98.8,98.4,94.6,102.5,95.5,98.2,101.5,100.8,102.5,104.4,126.4,68.6,102.6,102.4,100.3,102.5,100.8,99.2,1225.8,1219.8,1172.8,1270.7,1185,1217.8,1259.3,1249.9,1271.8,1294.2,1567.3,850.9,1272.1,1270,1243.7,1271.5,1250.6,1230.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y5K6","CD2-associated protein [OS=Homo sapiens]",41,23,57,23,639,71.4,6.4,150.5,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","CD2AP","ENSG00000198087","Bacterial invasion of epithelial cells","Nephrin family interactions","Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome; Genes controlling nephrogenesis",0.943,0.925,0.911,0.911,0.857,102,100,98.6,108.2,98.6,92.7,104,104.3,105.4,105.9,98.8,102.3,101,100.8,99.2,110.6,117.2,65.9,100.8,96.5,102.3,96.7,94.7,93.7,7183.4,7200.1,7278,7314,6819.1,7061,6977.3,6959.1,6853.3,7636.1,8096.1,4549.7,6957.7,6661.1,7064.1,6676.4,6540.7,6469.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q10589","bone marrow stromal antigen 2 [OS=Homo sapiens]",23,6,44,6,180,19.8,5.6,151.28,"stress response;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","BST2","ENSG00000130303","Herpes simplex virus 1 infection; Human immunodeficiency virus 1 infection","Neutrophil degranulation; Interferon alpha/beta signaling","Ebola virus pathway in host; Host-pathogen interaction of human coronaviruses - MAPK signaling",0.944,0.974,0.997,1.014,1.005,95.5,98.5,100.8,101.1,102.5,101.6,92.5,96,94.1,97.1,99.2,91.8,99.7,98.8,99.4,91.6,99.7,130,99.5,109.3,101.1,95.8,100.2,104.1,4899.6,5085.5,4985.1,5142.3,5255.2,4860.4,5278,5234.6,5263.5,4853.2,5279.5,6882.4,5268.1,5788.8,5354.9,5074.8,5307.7,5513.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P46939","Utrophin [OS=Homo sapiens]",13,36,47,36,3433,394.2,5.33,112.39,"developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","UTRN","ENSG00000152818","","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Primary focal segmental glomerulosclerosis (FSGS)",0.945,0.983,0.994,0.978,0.964,96.7,100.6,101.7,102.3,100.1,98.6,91.8,93.5,97.9,97.6,97.3,95.2,98.3,98.8,97.7,94.8,99,157.7,96.8,93.4,102.9,95.4,93.6,98.4,1866.5,1902.4,1992.1,1984.5,1979,1937.4,2000.4,2009.9,1987.4,1929.1,2013.3,3207.6,1968.6,1900.1,2092.9,1940.1,1904,2001.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q86X27-1","Ras-specific guanine nucleotide-releasing factor RalGPS2 [OS=Homo sapiens]",7,4,5,4,583,65.1,8.73,9.89,"signal transduction;other biological processes","plasma membrane;other membranes;other cell component","enzyme regulator activity","RALGPS2","ENSG00000116191","","","",0.945,1.015,0.958,1.052,0.925,96.2,103.3,97.5,101.8,107.1,94.1,96.1,89.7,91.3,99.7,98.1,86.9,94,91.1,92.6,94.2,96.6,192.4,101.7,97.2,102.1,87.5,89.4,99.3,414,386.5,393.4,429.4,422.7,374.2,404.7,392.4,399,405.5,416.3,828.8,438,418.6,440,376.9,385.1,427.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P55036-1","26S proteasome non-ATPase regulatory subunit 4 [OS=Homo sapiens]",58,17,82,5,377,40.7,4.79,237.76,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","PSMD4","ENSDLEG00000011513; ENSG00000159352; ENSPTRG00000013893; ENSRROG00000044190","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling pathway; Alzheimer's disease; Id signaling pathway",0.946,0.925,0.889,0.927,0.901,101.6,99.3,95.5,107.4,99.5,96.7,102.1,102.7,99.8,102.6,93.8,99.8,95.9,93.6,97.6,104.4,113.2,107.9,100.8,100,96,97.1,97.6,95,8250.3,8303.2,8069.2,8295.2,7580.1,8067.9,7754.3,7563.1,7892.5,8435.4,9153.3,8719.2,8146.4,8084.9,7760.4,7852,7886.6,7674.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P16885","1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [OS=Homo sapiens]",21,21,38,20,1265,147.8,6.64,79.61,"cell-cell signaling;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","PLCG2","ENSG00000197943","Inositol phosphate metabolism; Metabolic pathways; EGFR tyrosine kinase inhibitor resistance; ErbB signaling pathway; Ras signaling pathway; Calcium signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; HIF-1 signaling pathway; Phosphatidylinositol signaling system; Phospholipase D signaling pathway; Axon guidance; VEGF signaling pathway; Osteoclast differentiation; Platelet activation; Neutrophil extracellular trap formation; C-type lectin receptor signaling pathway; Natural killer cell mediated cytotoxicity; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Leukocyte transendothelial migration; Neurotrophin signaling pathway; Inflammatory mediator regulation of TRP channels; Thyroid hormone signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Shigellosis; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Proteoglycans in cancer; MicroRNAs in cancer; Glioma; Non-small cell lung cancer; Hepatocellular carcinoma","Generation of second messenger molecules; Role of phospholipids in phagocytosis; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; GPVI-mediated activation cascade; DAP12 signaling; CLEC7A (Dectin-1) signaling; Toll Like Receptor 4 (TLR4) Cascade; Synthesis of IP3 and IP4 in the cytosol; Erythropoietin activates Phospholipase C gamma (PLCG); Dectin-2 family","Leptin signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; Microglia pathogen phagocytosis pathway; GPR40 pathway; Ras signaling; Non-small cell lung cancer; Non-genomic actions of 1,25 dihydroxyvitamin D3; Resistin as a regulator of inflammation; EGFR tyrosine kinase inhibitor resistance; ErbB signaling pathway",0.947,0.997,0.956,0.947,0.954,97.9,103.1,98.9,103.4,97.9,98.7,97.6,95.4,97.5,98.7,106.2,102.7,105.3,98.5,96.6,103,91.4,111.7,95.4,97.6,102.3,98.3,97.4,104.3,2902.9,2837.5,2901.9,2937.6,3158.7,3055.3,3133.6,2929.4,2873.4,3065.2,2720.5,3323.3,2838.9,2902.3,3043.4,2924.8,2896.5,3102.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96PZ0","pseudouridylate synthase 7 homolog [OS=Homo sapiens]",25,12,30,12,661,75,6.37,117.33,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","PUS7","ENSG00000091127","","tRNA modification in the nucleus and cytosol","",0.948,0.937,0.934,0.953,0.944,99.5,98.4,98,105,100.1,99,99.6,97.7,100.3,100.8,95.7,98.5,95.3,98.2,99.8,106.6,105.1,102.4,100.2,97.1,103.1,99.1,99.2,101.4,1950.6,1912.5,1964.6,1974.1,1872.9,1928.9,1866.3,1921.7,1953.1,2086.6,2057.6,2004.1,1961.5,1900.8,2018.4,1940.6,1941.4,1985.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q5TC82-1","Roquin-1 [OS=Homo sapiens]",5,5,7,5,1133,125.7,7.27,18.54,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","other cell component","nucleic acid binding activity;other molecular function","RC3H1","ENSG00000135870","","","",0.949,0.973,0.919,0.92,0.879,101,103.5,97.8,106.4,97.9,93.5,98.3,97.7,102.5,100.7,100.7,102.7,95.2,101.9,93.9,101.8,103.5,141.8,95.2,99.8,92.8,87.6,93.2,90.9,853.1,848,889.6,874.7,874.5,891.3,826.2,884.4,814.9,883.5,898.6,1230.8,826.7,866.4,806,760.2,808.8,789.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8NCR0-1","UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 [OS=Homo sapiens]",5,2,2,2,500,56.7,5.71,6.89,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","B3GALNT2","ENSG00000162885; ENSG00000282880","Mannose type O-glycan biosynthesis; Metabolic pathways","O-linked glycosylation","",0.95,1.047,1.051,1.038,0.968,94.1,103.7,104.2,99.1,102.9,95.9,88.7,95.5,110.6,105.3,111.1,82.7,97,107,105.7,100.6,111.4,92.4,111.3,87.2,104.4,100.5,91.2,97.3,128,137.9,159.7,152,160.5,119.4,140,154.5,152.6,145.2,160.9,133.4,160.7,125.9,150.8,145.1,131.7,140.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UID3-1","Vacuolar protein sorting-associated protein 51 homolog [OS=Homo sapiens]",19,12,23,12,782,86,6.47,70.95,"cell organization and biogenesis;other metabolic processes;transport;developmental processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","","VPS51","ENSG00000149823","","Retrograde transport at the Trans-Golgi-Network","",0.95,0.987,0.999,0.983,1.007,96.2,99.9,101.2,101.2,99.5,102,92.6,93.1,93.1,96.7,94.4,100.1,95.1,97.9,98.3,98,94.7,161.4,93.3,96.3,99.4,99,98.7,98,2142.8,2155.4,2154.9,2238.1,2185.2,2316.1,2200.8,2266.9,2275.3,2268.5,2192.7,3735.8,2159.9,2229.1,2301.7,2291.6,2285.2,2267.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NXK8","F-box/LRR-repeat protein 12 [OS=Homo sapiens]",18,4,6,4,326,37,8.79,26.74,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","","FBXL12","ENSG00000127452","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",0.951,1.03,0.915,1.02,0.984,96.7,104.8,93.1,101.7,103.7,100.1,96.2,97.7,97.3,101.4,107.9,105.5,96.5,93.7,90,109.6,102.4,91.7,104.4,100.3,105.3,105.1,94.4,100.7,213.8,217,216.2,225.2,239.6,234.3,214.3,208.1,199.9,243.4,227.5,203.7,232,222.9,233.9,233.5,209.8,223.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q53H82","Endoribonuclease LACTB2 [OS=Homo sapiens]",41,10,28,10,288,32.8,6.8,96.92,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","nucleic acid binding activity;other molecular function","LACTB2","ENSG00000147592","","","",0.952,0.943,0.978,0.984,0.955,98.3,97.4,101,103.2,101.5,98.6,103.4,100.2,100.5,102.5,99.3,99.6,102.7,103.3,104.3,105.6,105.6,63.6,105.4,103.9,98.4,102.6,100.8,98.4,3083.9,2987.8,2996.9,3056.1,2962.7,2970.8,3062.3,3079.8,3110.6,3149.3,3149.9,1895.6,3143.4,3097.4,2933.7,3059.6,3007.2,2933.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P50552","Vasodilator-stimulated phosphoprotein [OS=Homo sapiens]",31,11,38,11,380,39.8,8.94,107.13,"cell organization and biogenesis;developmental processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","VASP","ENSG00000125753","Rap1 signaling pathway; cGMP-PKG signaling pathway; Focal adhesion; Tight junction; Platelet activation; Fc gamma R-mediated phagocytosis; Leukocyte transendothelial migration","Generation of second messenger molecules; Signaling by ROBO receptors; Cell-extracellular matrix interactions","Integrin-mediated cell adhesion; Focal adhesion",0.952,0.968,0.972,0.952,0.926,99,100.6,101.1,104,99,96.3,102,99.2,97.4,101.9,98.1,100.8,101.6,100,101.2,104.1,107.4,96.9,99.1,101.1,96.8,100.3,96.4,95.8,3446.8,3351.3,3291.2,3444.2,3315.3,3405.4,3435,3378.5,3419.5,3519.4,3629.6,3275.3,3349.7,3415.5,3272.4,3389.9,3257.5,3238,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q7Z2T5-1","TRMT1-like protein [OS=Homo sapiens]",35,20,42,20,733,81.7,7.88,137.23,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","TRMT1L","ENSG00000121486","","","",0.953,0.991,0.907,0.931,0.894,100.7,104.8,95.9,105.7,98.4,94.5,100.6,102,106.5,102.6,106.1,108.9,96.9,98,97.1,107,108,83,95.7,99.6,100.8,95,95.7,96.7,3635.7,3685.7,3848.2,3708.9,3833.8,3936.8,3504,3541.5,3509.2,3868.3,3902.4,2999.2,3458.8,3602.1,3644,3435.9,3458.7,3494.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BYM8","ranBP-type and C3HC4-type zinc finger-containing protein 1 [OS=Homo sapiens]",23,8,13,8,510,57.5,5.67,40.46,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;other cell component","other molecular function","RBCK1","ENSG00000125826","Necroptosis; NOD-like receptor signaling pathway; Shigellosis","Antigen processing: Ubiquitination & Proteasome degradation; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway","Regulation of toll-like receptor signaling pathway",0.954,0.959,0.936,0.955,0.926,99.9,100.4,98,104.7,100,97,100,92.7,96.6,99.1,97.1,93.6,96.7,93.1,94.7,101.2,99.8,160.3,99.4,95.7,96.7,95.9,93.8,93.6,1111,1029.5,1072.3,1100.2,1078.5,1039.2,1074.1,1034.2,1052.1,1124.4,1108.9,1780.3,1103.5,1062.6,1073.5,1065.2,1041.4,1039.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P51970","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [OS=Homo sapiens]",5,1,2,1,172,20.1,7.65,0,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity;other molecular function","NDUFA8","ENSG00000119421","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",0.954,0.911,0.884,0.908,0.873,103.5,98.8,95.9,108.5,98.5,94.8,108.8,95.9,102.7,97.8,98.1,103.8,95.9,95.2,93.4,121.8,107.7,79.1,97.8,109.7,95,93,110.3,94.1,79.5,70.2,75.1,71.5,71.7,75.9,70.1,69.6,68.3,89,78.8,57.8,71.5,80.2,69.5,68,80.7,68.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q53EZ4-1","Centrosomal protein of 55 kDa [OS=Homo sapiens]",21,9,13,9,464,54.1,7.01,32.64,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cell component","other molecular function","CEP55","ENSG00000138180","","","",0.955,0.797,0.762,0.762,0.845,111.9,93.4,89.3,117.2,89.2,99,104.4,112.6,94.5,85.4,87.1,120.1,83.3,74.9,91.8,106.9,109.3,165.1,99.5,83.3,78.9,92.4,121.5,89.1,955.1,1030.6,865.2,781.6,797,1098.8,762.5,685.5,839.7,978.3,1000.4,1511.2,910.1,761.9,722.3,845.5,1111.5,815.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q92619","Rho GTPase-activating protein 45 [OS=Homo sapiens]",41,41,194,41,1136,124.5,6.1,604.82,"signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","ARHGAP45","ENSG00000180448","","Neutrophil degranulation; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle","",0.955,0.943,0.953,0.982,0.967,98.8,97.5,98.6,103.4,101.6,100,101.1,96.8,97.8,96.9,96.6,95.1,101.3,97.5,97.6,102.5,100.8,116,100.6,101.6,99.9,99.1,97.6,101,22987.2,22019.1,22246.5,22034.9,21967,21631.6,23028.8,22175.6,22199.7,23295.4,22921.4,26382.7,22879.6,23104.3,22714.7,22525.3,22190.5,22975.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P22670","MHC class II regulatory factor RFX1 [OS=Homo sapiens]",15,8,14,8,979,104.7,6.29,51.72,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RFX1","ENSG00000132005; ENSG00000288283","","","",0.955,0.984,0.99,0.938,0.978,98.1,101,101.7,102.6,96.2,100.4,95.8,94.1,96.2,98.7,99.9,97.3,99.3,97,100.4,100.3,97.1,146.9,94,96.6,93.8,98.1,93.1,101.3,805.6,791.2,808.6,829.6,840.1,818.2,835,815.7,843.7,843.1,816.6,1234.8,790.5,812,788.5,824.9,782.6,851.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q0P651-1","Protein ABHD18 [OS=Homo sapiens]",5,2,3,2,414,46.9,9.28,6.9,"","non-structural extracellular","","ABHD18","ENSG00000164074","","","",0.956,0.982,0.947,0.987,0.885,99.7,102.4,98.7,104.2,102.8,92.2,81.4,79.7,78.9,81.8,83.6,79.7,75.4,81.5,78.9,81.2,83.3,446.9,79.5,85,82.2,73.7,72,75.2,417.3,408.3,404.5,419.4,428.3,408.7,386.6,417.9,404.3,416.2,426.9,2290.2,407.4,435.6,421.2,377.7,368.8,385.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9P0J7","E3 ubiquitin-protein ligase KCMF1 [OS=Homo sapiens]",40,9,22,9,381,41.9,5.66,85.13,"cell-cell signaling;protein metabolism;other metabolic processes","non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component","other molecular function","KCMF1","ENSG00000176407","","Neutrophil degranulation","",0.957,0.967,0.93,0.937,0.865,101.5,102.6,98.7,106.1,99.4,91.7,104.4,100.5,100,104.3,101.5,101.5,97.8,97.7,96.2,105,104.1,109.8,94.8,101.8,98.4,90.8,90.7,100.5,1654.8,1593.6,1584.4,1653.2,1609,1609.6,1550.2,1548.9,1525.1,1664.7,1649.7,1741.1,1502.3,1613.8,1560.4,1440,1437.5,1593.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P15151-1","Poliovirus receptor [OS=Homo sapiens]",6,2,2,2,417,45.3,6.52,2.97,"cell adhesion;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","other molecular function","PVR","ENSG00000073008","Cell adhesion molecules","Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Nectin/Necl  trans heterodimerization","Interactions of natural killer cells in pancreatic cancer",0.958,0.924,0.947,0.949,0.913,101,97.4,99.8,105.4,100.1,96.3,111.2,87.9,94.7,91.3,87.6,92.8,91.9,99.8,93.6,98.9,93,186.7,93.9,81.9,110.2,89.9,90.3,104.6,105.7,83.5,90,86.8,83.2,88.2,87.4,94.9,89,94,88.4,177.5,89.2,77.9,104.8,85.5,85.8,99.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q15181","Inorganic pyrophosphatase [OS=Homo sapiens]",80,20,170,19,289,32.6,5.86,602.98,"other metabolic processes","cytosol;other cell component","other molecular function","PPA1","ENSG00000180817","Oxidative phosphorylation","Cytosolic tRNA aminoacylation; Pyrophosphate hydrolysis","",0.958,0.856,0.901,0.881,0.945,103.7,92.7,97.5,108.3,95.4,102.4,97.9,102.8,103.1,91.8,90.5,101.5,98.1,93.5,96.6,107.3,101.3,117.7,103.3,94.6,91.7,101.4,112,94.6,25470.6,26750.4,26837.2,23892.1,23556.1,26418,25523.1,24324.8,25145.1,27920.9,26370.6,30632.3,26885.7,24610.8,23862.8,26395.5,29135.7,24620.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P62851","40S ribosomal protein S25 [OS=Homo sapiens]",22,3,4,3,125,13.7,10.11,10,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;translational apparatus;nucleus;other cell component","other molecular function","RPS25","ENSG00000118181; ENSG00000280831","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; SRP-dependent cotranslational protein targeting to membrane; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition","Cytoplasmic ribosomal proteins",0.959,1.011,1.022,0.99,0.974,96.6,101.8,103,100.8,99.7,98.1,86.6,97.6,103.1,107.2,102.9,92.7,106.3,104.1,94.1,101.8,100.9,102.8,107.4,100.8,99.9,101.5,99.1,91.2,593.2,668.5,705.8,733.8,704.6,634.6,728,712.7,644.6,697.2,690.5,703.7,735.4,690,683.9,694.6,678.8,624.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O43598-1","2'-deoxynucleoside 5'-phosphate N-hydrolase 1 [OS=Homo sapiens]",68,8,60,8,174,19.1,5.05,166.11,"other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","C6orf108; DNPH1","ENSG00000112667","","Purine catabolism","",0.96,0.877,0.891,0.866,0.958,103.7,94.8,96.3,108.1,93.6,103.5,101.4,102.5,96.1,92.7,87.3,103.8,94.2,88.4,97.5,105.6,105.7,129.6,100.9,91.5,89.8,101.2,114.8,97.1,5462.2,5522.3,5174.7,4990.4,4699.4,5588.8,5072.7,4759.7,5249.5,5684.6,5691.1,6981.2,5433.2,4930.4,4838.9,5450.9,6180.5,5231.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q92794","histone acetyltransferase KAT6A [OS=Homo sapiens]",2,3,3,3,2004,224.9,5.68,3.69,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","KAT6A","ENSG00000083168","Signaling pathways regulating pluripotency of stem cells","HATs acetylate histones; Regulation of TP53 Activity through Acetylation","Pathways affected in adenoid cystic carcinoma",0.961,1.027,0.976,0.896,0.896,100.1,107,101.8,104.2,93.4,93.4,92.6,104.2,99.1,111.4,98.3,105.9,96.8,100.7,102.2,90,103.2,135.7,92.5,91.8,101.6,97,92.5,84.4,488.1,549.5,522.7,587.5,518.1,558.6,510.2,531.1,538.9,474.6,544,715.2,487.6,484,535.8,511.5,487.4,444.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P17010","Zinc finger X-chromosomal protein [OS=Homo sapiens]",8,6,11,6,805,90.5,6.14,32.86,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZFX","ENSG00000005889","","","Hematopoietic stem cell gene regulation by GABP alpha/beta complex",0.961,0.947,0.93,0.987,0.938,100,98.6,96.8,104.1,102.8,97.6,86.6,93.1,93.4,91.8,96.3,88.5,92,90.1,90,93.5,96.9,230.3,95.7,94.3,100.4,85.3,91,90.9,594.5,639,641.4,629.8,661.1,607.2,631.5,618.6,617.9,641.8,665,1580.7,656.6,647.1,689.2,585.4,624.7,623.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q13347","Eukaryotic translation initiation factor 3 subunit I [OS=Homo sapiens]",54,13,80,13,325,36.5,5.64,231.84,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity","EIF3I","ENSG00000084623","","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell",0.962,1.006,0.979,1.006,0.986,97.1,101.7,98.9,101,101.6,99.6,102.4,96,96.2,95.8,106,100.7,97.3,100.6,98,111,100,93.3,95.5,100.6,105,97.8,98.7,105.2,8575.5,8041.8,8059.3,8026.1,8876.9,8435.3,8150.2,8429.3,8207.5,9294.7,8381.1,7815.1,7999.8,8427.4,8797.4,8193.9,8267,8813.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P04259","keratin, type II cytoskeletal 6B [OS=Homo sapiens]",31,21,79,2,564,60,8,188.7,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","cytoskeletal activity","KRT6B","ENSG00000185479","","Formation of the cornified envelope","",0.963,1.008,1.022,0.869,1.017,98.2,102.8,104.3,102.1,88.7,103.8,94.7,82.3,81.2,94.7,69.9,86.1,87.4,118.9,86.6,64.2,85.5,190.6,74.3,61.8,270.9,87.3,76.8,86.9,287.4,249.6,246.2,287.3,212.1,261.3,265.1,360.6,262.9,194.8,259.3,578.2,225.4,187.6,822,264.8,233.1,263.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NSV4-3","Protein diaphanous homolog 3 [OS=Homo sapiens]",7,7,7,7,1193,136.8,7.03,17.67,"cell organization and biogenesis","cytosol;nucleus;other cell component","cytoskeletal activity;other molecular function","DIAPH3","ENSG00000139734","Regulation of actin cytoskeleton","RHO GTPases Activate Formins; RHOQ GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOJ GTPase cycle; RHOC GTPase cycle; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle","Regulation of actin cytoskeleton",0.964,0.95,0.919,0.965,1.005,99.6,98.3,95,103.4,99.8,103.9,101,93.7,96.7,96.8,91.4,95.4,92.3,87,99,100.4,97.5,154.1,96.4,96.9,106.9,92.6,100.9,101.1,369.8,343,354.2,354.5,334.8,349.4,337.9,318.7,362.6,367.6,357,564.3,352.9,354.9,391.3,339.2,369.6,370.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q16644","MAP kinase-activated protein kinase 3 [OS=Homo sapiens]",18,6,11,4,382,43,7.28,33.37,"protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","MAPKAPK3","ENSG00000114738","MAPK signaling pathway; VEGF signaling pathway","Oxidative Stress Induced Senescence; VEGFA-VEGFR2 Pathway; p38MAPK events; activated TAK1 mediates p38 MAPK activation","Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway",0.964,0.925,0.922,0.996,0.96,100.3,96.2,95.9,104,103.6,99.9,99.2,104.1,100.3,97.1,96.2,90.2,94.7,99.1,95.9,102.8,104.9,104,105.9,103.6,100.3,103.3,98.5,99.9,789.7,828.3,798,772.3,765.2,717.7,753.8,788.9,762.9,817.8,835.1,827.6,842.6,824.3,798.5,822.1,784.1,794.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y666","Solute carrier family 12 member 7 [OS=Homo sapiens]",8,8,13,7,1083,119,6.71,26.59,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;other cell component","transporter activity;other molecular function","SLC12A7","ENSG00000113504","Collecting duct acid secretion","Cation-coupled Chloride cotransporters","",0.965,0.993,0.992,1.026,1.008,96.8,99.5,99.5,100.3,102.8,101.1,93.8,92.6,96.2,101,96.4,96.3,102,96.4,94.5,89.5,97.1,153.5,98.2,100.2,99.6,94.7,97.9,100,537.8,531.1,551.9,579.3,553,552.6,585,552.8,542.2,513.3,557.1,880.5,563.5,574.6,571.4,543.4,561.4,573.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P19525","interferon-induced, double-stranded RNA-activated protein kinase [OS=Homo sapiens]",34,15,42,15,551,62.1,8.4,112.9,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;translational apparatus;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;kinase activity;other molecular function","EIF2AK2","ENSG00000055332","Protein processing in endoplasmic reticulum; Necroptosis; Alzheimer disease; Hepatitis C; Measles; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease; Viral carcinogenesis","ISG15 antiviral mechanism; Inhibition of PKR","Translation factors; Alzheimer's disease and miRNA effects; Ebola virus pathway in host; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; Alzheimer's disease; Type II interferon signaling (IFNG)",0.966,0.953,0.982,0.985,1.004,98.4,97.1,100,101.9,100.3,102.3,98.3,97.5,99,96.1,100.5,97,98,102.2,99.9,104.1,97.7,101.8,102,98,100.2,103.5,102,102.2,5246.5,5203.6,5286.5,5129.5,5365.6,5178.8,5228.9,5454.3,5334.2,5558.7,5215.3,5432.6,5446.1,5230.8,5349.7,5523.9,5443,5455.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O14979-1","Heterogeneous nuclear ribonucleoprotein D-like [OS=Homo sapiens]",30,15,127,13,420,46.4,9.57,302.04,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","HNRNPDL; HNRPDL","ENSG00000152795; ENSPPAG00000043177; ENSPTRG00000016217","","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","",0.967,0.915,0.945,0.944,0.937,101.6,96.2,99.4,105.1,99.2,98.5,103,102.4,104.1,103.2,90.7,97.5,98.7,101.5,100.7,106.5,118,75,100.5,101.3,99.7,99.9,100.7,96.7,12222.5,12146,12348.1,12250.1,10759.2,11566.8,11707.2,12044.6,11950.2,12641.1,14005.7,8899.1,11930.3,12022.5,11833.2,11850.6,11946.5,11474.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NWT6","Hypoxia-inducible factor 1-alpha inhibitor [OS=Homo sapiens]",17,4,12,4,349,40.3,5.57,42.86,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","HIF1AN","ENSG00000166135","","Cellular response to hypoxia","MicroRNA for targeting cancer growth and vascularization in glioblastoma; Photodynamic therapy-induced HIF-1 survival signaling",0.967,1.004,0.864,0.876,0.848,104.4,108.4,93.3,107.9,94.5,91.5,94.8,102.7,99,104.1,102.8,101.4,88.5,92.1,85.5,97.1,102.4,200.6,87.7,89.6,91.9,84.3,88.5,86.8,655.5,709.9,684.4,719.7,710.6,700.7,611.5,636.8,591.1,670.8,707.4,1386,606,619.4,635,582.6,611.9,600.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96LT9","RNA-binding protein 40 [OS=Homo sapiens]",4,2,2,2,517,58.5,7.72,2.09,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity","RNPC3","ENSG00000185946","","mRNA Splicing - Minor Pathway","",0.969,0.985,1.003,0.923,0.94,99.9,101.5,103.4,103.1,95.2,96.9,95.5,100.6,114.1,112.7,101.3,102.3,105.9,103.7,104.2,112.7,103.9,54.9,106.7,95.9,95.7,100.5,97.7,91.6,263.9,278.1,315.4,311.5,279.9,282.7,292.7,286.6,287.9,311.4,287.1,151.9,294.9,265.1,264.5,277.7,269.9,253.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BWH6","RNA polymerase II-associated protein 1 [OS=Homo sapiens]",9,8,14,8,1393,152.7,6.38,45.8,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","RPAP1","ENSG00000103932","","","",0.97,0.991,1.019,0.971,1.011,97.6,99.7,102.6,100.6,97.7,101.8,97,96.7,99.1,97.7,105.5,99.1,101.8,102,102.4,100.1,92.2,106.7,94,97.2,104.5,101.2,98.6,104.1,807.3,804.8,824.7,813.2,877.3,824.7,847,848.8,851.9,832.6,767.2,888,781.7,808.4,869.3,841.9,820.3,866.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P13598","Intercellular adhesion molecule 2 [OS=Homo sapiens]",8,2,2,2,275,30.6,7.43,7.3,"cell adhesion","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding","ICAM2","ENSG00000108622","Cell adhesion molecules; Natural killer cell mediated cytotoxicity","Integrin cell surface interactions; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; CD209 (DC-SIGN) signaling","Complement system; Ebola virus pathway in host",0.97,0.969,0.989,1.007,0.968,98.6,98.5,100.5,101.6,102.4,98.4,98.6,99.7,92.9,110,96,98.6,112.2,97.4,100.5,101.7,104.5,83.6,100.9,105.8,102.4,96.6,100.1,98.5,384.2,388.6,361.9,428.5,373.9,384,437,379.4,391.6,396.1,407.2,325.5,393.2,412.1,398.9,376.5,389.9,383.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P48729-1","Casein kinase I isoform alpha [OS=Homo sapiens]",23,8,15,1,337,38.9,9.57,25.41,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","Csnk1a1; CSNK1A1; LOC101341353; LOC111140875; LOC114108773","ENSAMEG00000005335; ENSANAG00000021098; ENSCCAG00000036479; ENSCJAG00000021121; ENSCPOG00000036829; ENSFCAG00000031849; ENSG00000113712; ENSGGOG00000013926; ENSLCNG00005006253; ENSMMUG00000001758; ENSMNEG00000036153; ENSMUSG00000024576; ENSOARG00000005440; ENSOCUG00000006669; ENSPPAG00000041093; ENSPTRG00000017401; ENSRFEG00010012571; ENSRNOG00000017106; ENSSBOG00000025117; ENSSSCG00000014435; ENSSSCG00070006895; ENSSSUG00005020718; ENSUAMG00000019595; ENSUMAG00000005410","Wnt signaling pathway; Hedgehog signaling pathway; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Breast cancer; Hepatocellular carcinoma; Gastric cancer","Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Activation of SMO; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; S33 mutants of beta-catenin aren't phosphorylated; S37 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; T41 mutants of beta-catenin aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Maturation of nucleoprotein; GLI3 is processed to GLI3R by the proteasome; Beta-catenin phosphorylation cascade; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Activation of SMO","Alzheimer's disease and miRNA effects; T cell receptor and co-stimulatory signaling; Complement system; Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; Regulation of Wnt / B-catenin signaling by small molecule compounds; Wnt signaling pathway (NetPath); Chromosomal and microsatellite instability in colorectal cancer ; Hedgehog signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Malignant pleural mesothelioma; Alzheimer's disease",0.97,1.05,0.987,0.873,0.93,100.2,108.5,101.9,103.3,90.1,96.1,102.9,103.6,102.8,111.4,101.1,115.3,98.3,104.7,106.9,106.1,112.4,62.9,92.1,93.1,92.5,101.2,98.7,94,1546.5,1557.4,1545.1,1673.7,1518.7,1733.1,1477.6,1572.9,1607,1593.7,1688.7,944.6,1384.3,1399.3,1390.5,1521.1,1482.6,1412.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P49137","MAP kinase-activated protein kinase 2 [OS=Homo sapiens]",17,7,14,5,400,45.5,8.68,31.3,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","MAPKAPK2","ENSG00000162889","MAPK signaling pathway; Cellular senescence; VEGF signaling pathway; C-type lectin receptor signaling pathway; Neurotrophin signaling pathway; Kaposi sarcoma-associated herpesvirus infection; Viral carcinogenesis","VEGFA-VEGFR2 Pathway; Oxidative Stress Induced Senescence; activated TAK1 mediates p38 MAPK activation; Regulation of HSF1-mediated heat shock response; p38MAPK events; CREB phosphorylation; Synthesis of Leukotrienes (LT) and Eoxins (EX); Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA","IL-1 signaling pathway; Microtubule cytoskeleton regulation; Interleukin-1 (IL-1) structural pathway; Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; VEGFA-VEGFR2 signaling pathway; p38 MAPK signaling pathway; Malignant pleural mesothelioma; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling",0.971,1.02,0.985,0.984,0.977,98.1,103.1,99.6,101.1,99.5,98.7,97,99.5,97.1,102.1,99.4,107.7,96.8,98.6,101.4,96.2,100,119.7,98.5,92.2,99,99.9,97.2,97.7,1290.7,1324.3,1292.4,1358.6,1323.1,1432.7,1288.9,1312.1,1349.3,1280.7,1331.5,1593.3,1310.6,1226.9,1317.9,1329.3,1293.6,1300.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8IYS1","Peptidase M20 domain-containing protein 2 [OS=Homo sapiens]",51,17,62,16,436,47.7,5.85,200.63,"protein metabolism;other biological processes","nucleus","other molecular function","PM20D2","ENSG00000146281","","","",0.971,0.991,1.007,0.993,1.005,97.7,99.6,101.2,100.6,99.8,101.1,98.5,96.9,96.9,101.1,98.9,97.9,97,100.5,102.8,98.8,99.8,114,99.1,101.7,97,101.4,97.4,100.3,7498.2,7372,7377.4,7696.2,7523.6,7450.9,7379,7644.8,7824.2,7518.8,7594,8671.3,7539.9,7742.5,7377.8,7716.9,7414.7,7632.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P27361-1","mitogen-activated protein kinase 3 [OS=Homo sapiens]",34,12,56,8,379,43.1,6.74,171.45,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","MAPK3","ENSG00000102882; ENSPTRG00000007988","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; Platinum drug resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Oocyte meiosis; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Cellular senescence; Adrenergic signaling in cardiomyocytes; Vascular smooth muscle contraction; TGF-beta signaling pathway; Axon guidance; VEGF signaling pathway; Apelin signaling pathway; Osteoclast differentiation; Focal adhesion; Adherens junction; Gap junction; Signaling pathways regulating pluripotency of stem cells; Platelet activation; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; C-type lectin receptor signaling pathway; Natural killer cell mediated cytotoxicity; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; TNF signaling pathway; Circadian entrainment; Long-term potentiation; Neurotrophin signaling pathway; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; Long-term depression; Regulation of actin cytoskeleton; Insulin signaling pathway; GnRH signaling pathway; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Melanogenesis; Prolactin signaling pathway; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Relaxin signaling pathway; Parathyroid hormone synthesis, secretion and action; GnRH secretion; Type II diabetes mellitus; AGE-RAGE signaling pathway in diabetic complications; Cushing syndrome; Growth hormone synthesis, secretion and action; Aldosterone-regulated sodium reabsorption; Alzheimer disease; Prion disease; Pathways of neurodegeneration; Alcoholism; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Yersinia infection; Leishmaniasis; Chagas disease; Toxoplasmosis; Tuberculosis; Hepatitis C; Hepatitis B; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Thyroid cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis","PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Regulation of PTEN gene transcription; FCGR3A-mediated phagocytosis; NCAM signaling for neurite out-growth; ISG15 antiviral mechanism; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Signaling by BRAF and RAF1 fusions; Spry regulation of FGF signaling; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Negative feedback regulation of MAPK pathway; Signal transduction by L1; Suppression of apoptosis; RHO GTPases Activate WASPs and WAVEs; Regulation of HSF1-mediated heat shock response; Thrombin signalling through proteinase activated receptors (PARs); Oxidative Stress Induced Senescence; Signaling by NODAL; Oncogene Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Growth hormone receptor signaling; Regulation of the apoptosome activity; RUNX2 regulates osteoblast differentiation; RSK activation; MAPK3 (ERK1) activation; RNA Polymerase I Promoter Opening; Signaling by Activin; Activation of the AP-1 family of transcription factors; Signal attenuation; Gastrin-CREB signalling pathway via PKC and MAPK; Nuclear events stimulated by ALK signaling in cancer; ESR-mediated signaling; Advanced glycosylation endproduct receptor signaling; RHO GTPases Activate NADPH Oxidases; ERKs are inactivated; Signaling by MAP2K mutants","IL-5 signaling pathway; Osteopontin signaling; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; PDGF pathway; S1P receptor signal transduction; Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; IL-3 signaling pathway; TCA cycle nutrient use and invasiveness of ovarian cancer; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; MFAP5-mediated ovarian cancer cell motility and invasiveness; RAC1/PAK1/p38/MMP2 pathway; IL-6 signaling pathway; Hepatitis C and hepatocellular carcinoma; Hypothesized pathways in pathogenesis of cardiovascular disease; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; BMP signaling in eyelid development; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; Prion disease pathway; Endometrial cancer; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Neovascularisation processes; Non-genomic actions of 1,25 dihydroxyvitamin D3; Bile acids synthesis and enterohepatic circulation ; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Regulatory circuits of the STAT3 signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; TGF-beta receptor signaling in skeletal dysplasias; Kisspeptin/kisspeptin receptor system in the ovary; CAMKK2 pathway; Disruption of postsynaptic signaling by CNV; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; 7q11.23 copy number variation syndrome; 16p11.2 proximal deletion syndrome; Neuroinflammation and glutamatergic signaling; Malignant pleural mesothelioma; Orexin receptor pathway; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; TGF-beta receptor signaling; EPO receptor signaling; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling; Toll-like receptor signaling pathway; EGFR1 signaling pathway; EPO receptor signaling; MAPK signaling pathway; Hepatocyte growth factor receptor signaling; Delta-Notch signaling pathway",0.972,1.069,1.013,1.031,1.036,95.3,104.8,99.3,98,101,101.6,94.1,96.7,93.9,99.3,103.4,103.5,96.8,98,99.2,96.8,95.1,119.9,96.9,99.7,101.7,100.3,99.6,105.1,3637.7,3739.7,3630.8,3840.2,3997.9,4000.7,3743.9,3788.9,3834.8,3740.9,3674.8,4636,3745.2,3855.2,3929.6,3876,3849.3,4062.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8TD46-1","Cell surface glycoprotein CD200 receptor 1 [OS=Homo sapiens]",3,1,2,1,325,36.6,7.93,4.78,"","","","","","","","",0.973,1.03,0.895,1.009,0.929,100,105.9,92,102.8,103.7,95.5,101.1,101.5,98.6,108.6,107.1,92.7,91.8,103.7,93.1,82.6,103.9,111.6,102.4,109.4,104.8,89.4,101.1,96.6,135.5,136,132.2,145.5,143.5,124.2,123,139,124.7,110.6,139.2,149.5,137.1,146.6,140.5,119.8,135.4,129.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NP79","Vacuolar protein sorting-associated protein VTA1 homolog [OS=Homo sapiens]",25,6,18,6,307,33.9,6.29,56.31,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","VTA1","ENSG00000009844","Endocytosis","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)","",0.973,0.89,0.896,0.865,0.944,104.9,95.9,96.6,107.8,93.2,101.7,106.1,108.4,101.9,92.4,97.1,106.3,97.7,89,101.2,109.1,112.5,73.8,99.3,94.3,92.5,103,113.2,102.3,2154.3,2199.7,2068.3,1875.3,1970.5,2158.3,1983.5,1806.4,2053.8,2213.9,2282.9,1497.3,2015.4,1914.3,1876.8,2089.6,2298.4,2075.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6ZVM7","TOM1-like protein 2 [OS=Homo sapiens]",27,8,13,8,507,55.5,4.79,33.39,"transport;signal transduction;other biological processes","other membranes;other cytoplasmic organelle","other molecular function","TOM1L2","ENSG00000175662","","","",0.974,1.019,0.919,0.914,0.846,103,107.8,97.2,105.8,96.7,89.5,100.3,100,106.1,104.9,105.4,101.1,94.6,99.2,92.2,101.5,103,148.3,94.6,92.1,94.1,85.9,87.1,89.4,850.9,848.3,900.1,889.9,894.5,858.1,802.7,841.6,782.5,861.2,873.7,1258.4,802.9,781.5,798.4,728.8,738.8,758.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96C23","aldose 1-epimerase [OS=Homo sapiens]",43,11,23,11,342,37.7,6.65,93.65,"other metabolic processes","other cell component","other molecular function","GALM","ENSG00000143891","Glycolysis / Gluconeogenesis; Galactose metabolism; Metabolic pathways","","",0.975,1.045,1.002,0.997,0.98,97.5,104.5,100.3,100,99.7,98,97.1,96.2,99.8,97.2,106.8,104.1,98.4,99.8,100.6,99.6,91.4,116,96.3,99.3,102.4,97.6,96.8,100.6,3245.5,3215,3334.3,3247.4,3569.5,3478.9,3288.6,3337.4,3363.9,3330,3056.2,3876.5,3218.8,3318.7,3422.8,3263.7,3235.7,3361.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q86UT6","NLR family member X1 [OS=Homo sapiens]",4,2,2,2,975,107.5,7.37,5.22,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;other cell component","other molecular function","NLRX1","ENSG00000160703","NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Influenza A","Negative regulators of DDX58/IFIH1 signaling","Novel intracellular components of RIG-I-like receptor (RLR) pathway; Genotoxicity pathway; Cytosolic DNA-sensing pathway; STING pathway in Kawasaki-like disease and COVID-19; Mitochondrial immune response to SARS-CoV-2",0.975,1.152,0.964,0.945,0.958,97.6,115.3,96.5,100.1,94.6,95.9,88.5,81.9,90.2,87.6,107.4,104.6,91.9,85.5,87.5,90.8,64.4,278.6,85.4,85.8,91.2,84.1,86.9,107.9,137.4,127.2,140.1,136.1,166.8,162.4,142.7,132.8,135.9,141,100,432.6,132.6,133.2,141.6,130.6,135,167.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O60906","Sphingomyelin phosphodiesterase 2 [OS=Homo sapiens]",6,2,3,2,423,47.6,6.98,6.62,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","SMPD2","ENSG00000135587","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway","Glycosphingolipid metabolism; Ceramide signalling; TNFR1-mediated ceramide production","TNF-alpha signaling pathway; S1P receptor signal transduction",0.976,1.163,1.034,1.04,1.009,94.1,112.2,99.7,96.4,100.3,97.3,78.3,94.6,86.3,103,92.8,102.9,86.8,91.5,93.7,72.4,88.5,284.4,92.7,75.7,92,89.2,94.8,80.4,60.4,73,66.6,79.5,71.6,79.4,67,70.6,72.3,55.9,68.3,219.4,71.6,58.4,71,68.8,73.2,62.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O14653-1","Golgi SNAP receptor complex member 2 [OS=Homo sapiens]",21,4,7,4,212,24.8,8.06,14.57,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","other molecular function","GOSR2","ENSG00000108433","SNARE interactions in vesicular transport","COPI-mediated anterograde transport; Intra-Golgi traffic; COPII-mediated vesicle transport; XBP1(S) activates chaperone genes; Cargo concentration in the ER","",0.976,0.947,0.953,0.916,0.874,103.3,100.3,100.9,105.9,97,92.5,105.4,101.8,103.3,100.3,95.2,100.3,100.8,101,99.2,105.8,120.5,98.3,91.6,103.2,97,90.1,93.8,92.5,639.4,617.6,626.4,608.1,577.5,608.6,611.4,612.8,601.6,641.8,730.6,596,555.4,625.9,588.1,546.5,569,560.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P55198","Protein AF-17 [OS=Homo sapiens]",1,2,2,1,1093,112,8.62,4.1,"","","other molecular function","MLLT6","","","","",0.977,0.898,0.879,0.9,0.924,105.1,96.6,94.5,107.6,96.9,99.4,118.3,110.1,106.9,101.2,103.7,78.8,81.1,99.1,113.3,122.1,112.8,32.7,101.5,94.6,114.7,104.2,93.4,111.5,89.7,83.5,81.1,76.8,78.6,59.8,61.5,75.1,85.9,92.6,85.5,24.8,77,71.7,86.9,79,70.8,84.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q16706","Alpha-mannosidase 2 [OS=Homo sapiens]",39,38,133,38,1144,131.1,7.58,408.21,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","MAN2A1","ENSG00000112893","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways","Intra-Golgi traffic; Maturation of spike protein; Reactions specific to the complex N-glycan synthesis pathway","",0.977,1.003,1.008,0.997,1.019,97.7,100.2,100.8,99.9,99.6,101.9,96.1,98,98.9,100,103.1,100.6,101.1,101.2,100.7,104.4,100.3,85.8,100,99.1,102.7,102.2,103.7,102,13430,13696.7,13824.7,13968.2,14408.6,14052.3,14130.5,14143.1,14073.6,14594.6,14014.5,11993.5,13968,13854.9,14350.2,14284.5,14492,14253.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P33241","Lymphocyte-specific protein 1 [OS=Homo sapiens]",63,14,114,14,339,37.2,4.74,523.24,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton","cytoskeletal activity","LSP1","ENSG00000130592; ENSG00000288199","C-type lectin receptor signaling pathway; Tuberculosis","","",0.978,1.021,1.049,0.991,0.973,97.6,101.9,104.7,99.8,98.9,97.1,98.1,95.8,100.5,107.6,102.4,93.7,109.9,105.2,99,100.3,110.1,82.8,98.8,99.4,102.1,97.6,95.1,101.8,10054.1,9817.3,10301.6,11027.1,10497.7,9602.1,11268,10782.7,10145.9,10279.9,11281.4,8485.5,10125.7,10187,10467.2,10001.8,9743.5,10435.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O00115","Deoxyribonuclease-2-alpha [OS=Homo sapiens]",10,4,11,4,360,39.6,8.05,21.95,"cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes","other cytoplasmic organelle","nucleic acid binding activity;other molecular function","DNASE2","ENSG00000105612","Lysosome","Lysosome Vesicle Biogenesis","",0.979,0.948,1.044,1.005,0.983,98.6,95.5,105.1,100.7,101.2,98.9,111.5,95.7,89.4,92.7,82.5,99.5,101.1,112.1,102.1,90.7,97.8,139,103.2,97.3,98.3,96.1,86.2,104.7,1475.2,1266.4,1182.5,1226.4,1091,1315.8,1336.6,1483,1350.3,1199.4,1293.7,1838.2,1365.7,1287.3,1300.6,1271.1,1140.7,1384.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BY50","Signal peptidase complex catalytic subunit SEC11C [OS=Homo sapiens]",33,7,57,7,192,21.5,9.2,140.87,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","SEC11C","ENSG00000166562","Protein export","SRP-dependent cotranslational protein targeting to membrane; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP); Synthesis, secretion, and deacylation of Ghrelin","",0.979,1.023,1.058,1.035,1.029,95.9,100.2,103.7,98,101.4,100.8,94.6,97.4,92.3,98.9,99.8,95.6,102.3,100.4,102.4,96.4,96.6,119.7,100,104.8,98.4,99.4,97.8,103.1,7800.3,8031.8,7612.4,8150.7,8231.7,7882.1,8431,8280.7,8439.5,7946.7,7965.9,9867.3,8246.1,8639.8,8115.3,8197.5,8065.3,8497.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8TB40","Protein ABHD4 [OS=Homo sapiens]",5,1,1,1,342,38.8,7.59,4.38,"other metabolic processes;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","ABHD4","ENSG00000100439","","Acyl chain remodelling of PE","",0.98,1.056,0.959,0.888,0.964,100.6,108.4,98.4,102.6,91.2,98.9,103.8,98.2,77.7,105.8,114.5,102.6,91.4,114.7,96,100.2,79.6,178.7,79.2,91,89,84,96.6,97.2,24.6,23.2,18.4,25,27.1,24.3,21.6,27.1,22.7,23.7,18.8,42.3,18.7,21.5,21,19.9,22.8,23,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P51798-1","H(+)/Cl(-) exchange transporter 7 [OS=Homo sapiens]",8,7,16,7,805,88.6,8.43,50.56,"transport;other biological processes","other membranes;nucleus;other cell component","transporter activity;other molecular function","CLCN7","ENSG00000103249","","Stimuli-sensing channels","Autosomal recessive osteopetrosis pathways",0.98,1.037,0.989,1.043,0.998,97.3,102.9,98.2,99.2,103.5,99,90.9,98.3,94.7,100.7,100.1,94.2,96.9,94.3,95.6,90.5,96.6,153.5,97.4,100.7,104.9,96.4,94.3,100,1412.9,1528.1,1472.7,1566.3,1557.2,1464.8,1507,1466.3,1486.4,1408,1502.1,2387.8,1514.9,1566.7,1631.7,1499,1466.6,1554.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6QHF9","Peroxisomal N(1)-acetyl-spermine/spermidine oxidase [OS=Homo sapiens]",2,1,1,1,649,70.2,5.53,4.1,"","","","","","","","",0.981,1.094,1.093,1.15,1.087,91.9,102.5,102.4,93.7,107.7,101.8,88.8,75.3,95.8,94.8,116,99.1,80.8,112.5,98.9,90.5,86.3,153.8,99.2,104.1,111.7,94.1,98.4,99.7,42.6,36.1,45.9,45.4,55.6,47.5,38.7,53.9,47.4,43.4,41.4,73.7,47.5,49.9,53.5,45.1,47.1,47.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UK45","U6 snRNA-associated Sm-like protein LSm7 [OS=Homo sapiens]",54,5,11,5,103,11.6,5.27,20.11,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","LSM7","ENSG00000130332","RNA degradation; Spliceosome","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease","mRNA processing",0.981,0.961,0.931,0.914,0.99,101.9,99.8,96.7,103.9,94.9,102.8,103.3,105.3,100.2,101.1,84.5,112.2,90.3,98,100.3,105.2,110.9,79.9,96.8,96.1,96.2,104.2,120.5,95.1,1180.8,1204,1145.5,1156,966,1283.2,1032.5,1120.1,1147.2,1203.1,1268.4,913.7,1107,1098.9,1099.7,1191.2,1378,1088,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P82675","28S ribosomal protein S5, mitochondrial [OS=Homo sapiens]",39,15,55,15,430,48,9.92,150.2,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPS5","ENSG00000144029","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",0.982,0.997,0.967,1.008,0.993,99.1,100.6,97.5,100.9,101.8,100.2,100.7,99.1,99.2,100.6,103.3,95.2,102.2,96.1,97.6,101.7,101,98.3,101.9,101.9,99.4,101.8,100.2,99.9,6408.1,6306.3,6315.2,6407.9,6576.3,6059.5,6507.1,6117.3,6215.1,6475.1,6430.3,6257.4,6486.5,6484.5,6329.4,6482.3,6382.1,6358.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q13496","Myotubularin [OS=Homo sapiens]",16,8,14,8,603,69.9,8.18,39.69,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","MTM1","ENSG00000171100","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane","",0.983,1.032,0.991,1.002,0.966,98.7,103.7,99.5,100.4,100.7,97,103.6,98.2,97.1,106,103.1,99.9,99,95.8,99,99.9,97.3,113.7,100.1,96.9,100.1,96.5,94.5,99.3,1321,1252,1238,1351.3,1314.8,1274.5,1263,1221.1,1262.2,1274,1241.1,1450.2,1277,1236,1277.1,1230.4,1205,1266.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NZ32","Actin-related protein 10 [OS=Homo sapiens]",25,8,25,8,417,46.3,7.37,86.98,"transport;other biological processes","non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","","ACTR10","ENSG00000131966","Amyotrophic lateral sclerosis; Huntington disease; Pathways of neurodegeneration; Salmonella infection","MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Neutrophil degranulation","",0.983,1.025,1.002,0.992,0.977,98.7,102.8,100.5,100.4,99.5,98.1,96.9,98.8,94.8,99.3,101,101.8,96.2,98.7,102.4,98.6,97.9,128.1,95.1,98.2,97.7,95.6,96.3,102.6,1930.7,1969.6,1890.2,1979.3,2012.4,2028.8,1917.6,1967.6,2040.9,1964.2,1950.9,2553.4,1894.4,1957.4,1948,1905.3,1918.8,2044.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P78356","Phosphatidylinositol 5-phosphate 4-kinase type-2 beta [OS=Homo sapiens]",31,11,34,6,416,47.3,7.33,83,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle","kinase activity;other molecular function","PIP4K2B","ENSG00000276293; ENSG00000277292","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Regulation of actin cytoskeleton","Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs in the nucleus","Regulation of actin cytoskeleton",0.984,1.008,1.033,1.002,0.981,98.3,100.6,103.2,99.9,100.1,98,99.8,93.7,97.5,98.8,99.9,100.5,103.4,102.4,97.7,99.1,95.8,125.8,95.3,99.5,99.3,97.3,93.4,100.7,1426.4,1339.4,1393.7,1412.4,1427.3,1435.5,1477.7,1463.3,1395.6,1416.7,1369,1797.6,1361.7,1422,1419.6,1390.2,1335.2,1438.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6GMV2","SET and MYND domain-containing protein 5 [OS=Homo sapiens]",17,6,13,6,418,47.3,5.05,37.46,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","","other molecular function","SMYD5","ENSG00000135632","","","Histone modifications",0.984,1,1.018,1.024,0.99,98.2,99.8,101.5,99.7,102.1,98.7,97.9,97.8,96.4,101.7,96.1,99.4,99.5,101.1,106.4,99.4,98.7,108.2,95.9,101.8,101.7,98.3,97.3,102.3,1129.5,1128.9,1113,1173.9,1109.1,1147,1148.5,1167.2,1228.6,1147,1139.8,1248.5,1106.8,1174.6,1174.2,1135,1123.3,1181.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q69YL0","Uncharacterized protein NCBP2-AS2 [OS=Homo sapiens]",31,3,4,3,99,10.9,12,8.61,"","","","NCBP2AS2","ENSG00000270170","","","3q29 copy number variation syndrome",0.985,1.093,1.007,0.911,0.918,99.9,110.9,102.2,101.5,92.5,93.1,91.7,108.3,101.8,91.2,113,114,105.1,77.3,104.1,80.3,134.9,103.4,103.6,92.1,94.2,101,94.9,89.2,399.4,471.5,443.4,397.4,492,496.5,457.6,336.4,453.4,349.6,587.6,450.2,451,401.2,410.3,439.8,413.2,388.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P41240","tyrosine-protein kinase CSK [OS=Homo sapiens]",49,18,129,18,450,50.7,7.06,398.86,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","kinase activity;other molecular function","CSK","ENSG00000103653","Epithelial cell signaling in Helicobacter pylori infection","Phosphorylation of CD3 and TCR zeta chains; PD-1 signaling; Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Negative regulation of FLT3; GAB1 signalosome; Integrin signaling; RHOH GTPase cycle","Integrin-mediated cell adhesion; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton",0.985,1.022,1.012,1.017,1.028,97.5,101.1,100.1,98.9,100.6,101.7,96.5,97.4,98.4,101.1,101.6,99.2,99.4,100,101.5,98.9,94.8,104.7,100.5,100.5,101.7,101.7,100.4,101.6,13503.8,13635.7,13766.8,14143,14225.3,13888.6,13906.8,13998.9,14212.2,13836.7,13270.5,14659.4,14062.1,14071.2,14228.5,14226.5,14056.7,14225.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P57737-3","Isoform 3 of Coronin-7 [OS=Homo sapiens]",45,34,175,1,1048,114.1,6.33,558.65,"","","","CORO7","","","","",0.986,1.014,1.033,1.026,1.012,97.4,100.2,102.1,98.8,101.4,100,98.5,95.8,94.7,98.5,99.9,98.5,103.2,100.4,99.5,97.2,91.5,125.9,97.6,101.2,99.7,97.5,98.3,102.2,15556.6,15121.3,14954.5,15548.7,15769.1,15549.2,16297.8,15846.5,15717.9,15340.5,14453.8,19876.5,15406.5,15985.2,15736.5,15387.8,15520,16142.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q86WN1-1","F-BAR and double SH3 domains protein 1 [OS=Homo sapiens]",9,6,7,6,690,76.9,5.34,16.03,"cell-cell signaling;cell organization and biogenesis","cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","FCHSD1","ENSG00000197948","","","",0.986,0.979,0.961,0.963,0.962,101.1,100.4,98.6,102.5,98.7,98.7,97.6,99.1,100.4,98.3,104.6,96.7,97.9,95.6,96.5,95.9,100.4,136.8,97.7,96.7,95.9,97.5,95.7,96.6,907.2,920.8,933.3,913.8,972.1,898.6,910.2,888.6,897.4,891.6,933.5,1271.5,908.5,898.8,891.4,906,889.2,898.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96S15-2","Isoform 2 of GATOR complex protein WDR24 [OS=Homo sapiens]",9,7,10,7,790,88.2,6.52,24.95,"other metabolic processes;stress response;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","WDR24","ENSG00000127580; ENSPPAG00000030128; ENSPTRG00000007554","mTOR signaling pathway","Amino acids regulate mTORC1","",0.987,1.01,1.025,0.984,0.994,98.7,100.9,102.5,100,98.4,99.4,101,100.6,99.4,102.9,95.5,104.2,98.9,105.4,104.5,105.9,101.9,82.7,96.9,100.3,100.6,102.9,95.2,101.3,1062.8,1058.5,1046.4,1082.8,1005,1096.7,1040.4,1109.2,1099.8,1114.8,1072.5,870,1020.1,1055.8,1059.1,1082.8,1001.6,1066.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q86YN1-1","Dolichyldiphosphatase 1 [OS=Homo sapiens]",13,2,5,2,238,27,9.44,7.75,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","DOLPP1","ENSG00000167130; ENSPPAG00000038994; ENSPPYG00000019673; ENSPTRG00000021451; ENSPTRG00000047001","N-Glycan biosynthesis; Metabolic pathways","Synthesis of Dolichyl-phosphate","",0.987,1.001,0.989,0.996,1.006,99.1,100.4,99.3,100.3,100,100.9,97.9,88.4,100.2,95.2,99.2,109.3,100.4,90.9,98,99.1,88.9,144.8,85.4,119.9,98.7,75.8,108.2,99.7,131.3,118.6,134.4,127.8,133.1,146.7,134.7,122,131.6,133,119.3,194.3,114.6,160.9,132.5,101.7,145.2,133.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q2NKX8","Dna excision repair protein ercc-6-like [OS=Homo sapiens]",23,21,34,21,1250,141,5.31,102.91,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","ERCC6L","ENSG00000186871","","RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",0.988,0.99,1.031,0.991,0.954,99.6,99.8,103.9,100.7,99.9,96.1,94.3,93.3,95,93.4,94.5,97,98.4,98.4,91.9,93.8,95.4,195.7,94.5,93.1,97.4,89.5,93.7,91,2537.7,2511.3,2557.8,2514.1,2543,2610.4,2648.7,2648.2,2475,2524.6,2567.5,5268.8,2544.6,2508,2623,2409.2,2522.5,2449.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P61254","60S ribosomal protein L26 [OS=Homo sapiens]",23,5,14,5,145,17.2,10.55,26.61,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;translational apparatus;nucleus;other cell component","nucleic acid binding activity;other molecular function","RPL26","ENSG00000161970","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Peptide chain elongation; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","VEGFA-VEGFR2 signaling pathway; Cytoplasmic ribosomal proteins",0.989,0.883,0.963,0.891,1.037,102.9,91.9,100.2,104.1,92.8,108,88.6,108,104.9,93.5,93.7,108.6,106.8,102.1,95.4,106.1,108.3,73.6,102.9,94.6,91.3,110,116.8,94.9,2590.9,3159,3066.3,2733,2739.2,3175,3121.7,2985.9,2789.2,3101.5,3165.3,2152.8,3007.1,2764.8,2669.3,3216.4,3414.5,2774.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8NFT6-1","Protein DBF4 homolog B [OS=Homo sapiens]",1,1,1,1,615,67.2,8.34,0,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","DBF4B","ENSG00000161692","","","",0.989,1.043,1.099,1.072,1.027,95.3,100.4,105.9,96.3,103.2,98.9,97.1,91.6,90,98,96.6,84.8,104.5,100.4,101.8,92.7,90.6,168.2,99.3,100.3,93.2,102.5,95.2,93.3,639.5,603.6,592.6,645.4,636.5,558.7,688.1,661.3,670.8,610.3,596.5,1108,654.2,660.4,613.7,675,626.8,614.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8IXH7","Negative elongation factor C/D [OS=Homo sapiens]",25,11,27,11,590,66.2,5.1,83.75,"other biological processes","nucleus","nucleic acid binding activity","NELFCD","ENSG00000101158","","RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat","Initiation of transcription and translation elongation at the HIV-1 LTR",0.99,1.013,1.008,0.995,0.993,99,101.3,100.8,100,99.5,99.3,100.4,98.7,101.9,102.7,103.7,101.3,98.3,102.3,104.2,104.5,101.5,74,100.7,101,102.8,100.8,99.3,102.2,2324.9,2285.1,2357.6,2378.3,2399.8,2345,2275.3,2367.2,2411,2418.7,2348.7,1712.3,2330.4,2336.9,2378.8,2332.3,2298.5,2365,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P51858","hepatoma-derived growth factor [OS=Homo sapiens]",77,23,223,22,240,26.8,4.73,700.8,"signal transduction;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function","HDGF","ENSG00000143321","","XBP1(S) activates chaperone genes","IL-18 signaling pathway",0.991,1.017,1.089,1.117,1.017,95.4,98,104.9,96.3,107.6,97.9,94,93.1,109.9,114.2,96.5,86.1,103.4,105,95.3,91.6,102.5,94.9,106,105.5,108,101.8,96.5,95.7,24734.3,24487,28905.1,30053.3,25395.4,22646.5,27192,27629.2,25083.9,24105.3,26955.4,24965.5,27886.6,27759.3,28411.2,26772.3,25381.4,25189.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NYL9","tropomodulin-3 [OS=Homo sapiens]",59,20,75,18,352,39.6,5.19,252.04,"cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton","cytoskeletal activity","TMOD3","ENSG00000138594","","RND3 GTPase cycle; Striated Muscle Contraction; RHOBTB2 GTPase cycle","VEGFA-VEGFR2 signaling pathway",0.991,0.993,0.982,0.983,0.997,100,100.2,99.1,100.9,99.2,100.6,101.8,102.5,101.8,102,101.1,103,102.9,100.2,100.8,102.7,104.3,67.1,101.6,101,99.1,102.4,101.7,104,8660.5,8716.3,8656.7,8674.6,8605,8763.6,8755.3,8522.6,8577.7,8736.7,8877.1,5712.4,8645.9,8591.3,8428.1,8708.4,8654.3,8848.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q14353-1","guanidinoacetate N-methyltransferase [OS=Homo sapiens]",20,3,20,3,236,26.3,6.14,78.98,"other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","GAMT; HEL-S-20","ENSG00000130005","Glycine, serine and threonine metabolism; Arginine and proline metabolism; Metabolic pathways","Transcriptional Regulation by MECP2; Creatine metabolism","MECP2 and associated Rett syndrome",0.992,1.05,1.047,1.009,1.062,96.6,102.3,102,97.4,98.3,103.5,95.8,96.8,93.6,101.5,101,104.3,98.7,101.3,101.2,96.6,88.8,117.8,97.5,96.4,106.3,96.1,103.6,102.7,1045.2,1056,1020.3,1106.6,1101.6,1137,1076.9,1104.3,1103.7,1054,968.2,1284.9,1063.6,1051.4,1159.7,1048.4,1129.4,1119.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6IN84-1","rRNA methyltransferase 1, mitochondrial [OS=Homo sapiens]",14,3,8,3,353,38.6,7.94,26.76,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","other molecular function","MRM1","ENSG00000274853; ENSG00000278619","","rRNA modification in the mitochondrion","",0.993,1.035,1.086,1.13,1.064,94.4,98.5,103.3,95.1,107.5,101.2,97.1,89,93,94.9,97,104.2,102.4,98.2,101.8,87.9,119.6,93.7,105.9,109.1,103.9,96.3,106.4,99.6,126.9,116.2,121.4,123.9,126.7,136.1,133.8,128.3,132.9,114.8,156.2,122.3,138.3,142.5,135.7,125.8,139,130.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P62312","U6 snRNA-associated Sm-like protein LSm6 [OS=Homo sapiens]",43,4,6,4,80,9.1,9.58,13.28,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","LSM6","ENSG00000164167","RNA degradation; Spliceosome","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease","",0.993,0.974,0.95,0.946,0.955,102.4,100.5,98,103.1,97.5,98.5,100.4,109.1,98,98.5,91.4,114.5,89.5,96.1,100.5,98.1,101.1,106.2,101.2,93.8,95.7,96.6,112.9,96.3,1368.9,1487.8,1336.1,1343.8,1246.3,1560.9,1220.1,1310.6,1370.5,1337.1,1379.1,1448.8,1379.9,1279.5,1304.5,1317.7,1539.8,1313.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8WYQ5-1","Microprocessor complex subunit DGCR8 [OS=Homo sapiens]",5,4,4,4,773,86,5.95,11.49,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DGCR8","ENSG00000128191; ENSPPAG00000039507; ENSPTRG00000014073","","Transcriptional Regulation by MECP2; MicroRNA (miRNA) biogenesis","miRNA biogenesis; exRNA mechanism of action and biogenesis; DDX1 as a regulatory component of the Drosha microprocessor; 22q11.2 copy number variation syndrome",0.993,0.979,0.983,0.957,0.961,101.5,100,100.4,102.1,97.8,98.2,103,101.8,101.6,100.4,101.8,94.3,97.6,104.3,100.7,102.5,113.5,86.6,100.8,94.6,98.1,98.5,98.2,101.7,597.8,590.7,589.2,582.5,590.6,547,566.2,605.2,584.3,594.7,658.4,502.6,584.7,549.1,569.3,571.6,569.7,589.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BVC4","target of rapamycin complex subunit LST8 [OS=Homo sapiens]",22,5,8,5,326,35.9,5.86,33.51,"cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity","MLST8","ENSG00000167965","Autophagy; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; Thermogenesis","Constitutive Signaling by AKT1 E17K in Cancer; Regulation of TP53 Degradation; PIP3 activates AKT signaling; CD28 dependent PI3K/Akt signaling; VEGFR2 mediated vascular permeability; Macroautophagy; Amino acids regulate mTORC1; TP53 Regulates Metabolic Genes; Regulation of PTEN gene transcription; mTORC1-mediated signalling; Energy dependent regulation of mTOR by LKB1-AMPK; HSF1-dependent transactivation","Regulation of toll-like receptor signaling pathway; Target of rapamycin (TOR) signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K-Akt signaling pathway; Thermogenesis; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Autophagy; Malignant pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Interferon type I signaling pathways; Senescence and autophagy in cancer",0.994,1.01,1.044,1.093,1.048,96.4,97.9,101.2,96.9,106,101.6,107.4,91,97,98.3,103.2,98.5,101.8,102.7,100.2,100.4,97.5,93.8,95.7,107.5,106.6,92.7,102.2,103.5,583.6,494.7,527.1,534.2,561.2,535.4,553.5,558.3,544.6,545.5,530.1,510.1,520.2,584.1,579.5,503.7,555.3,562.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q2TAA5","GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase [OS=Homo sapiens]",3,1,1,1,492,55.6,8.48,3.83,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","ALG11","ENSG00000253710","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG11 causes CDG-1p","",0.995,1.105,1.075,1.165,1.073,93.1,103.4,100.5,93.6,109,100.4,78.3,104.8,94.2,104.6,113.2,103.7,112.6,101.7,91.8,94.6,97.7,61.7,110.3,112,103.6,96.1,101.5,117.7,59.2,79.2,71.2,79,85.5,78.4,85.1,76.9,69.4,71.5,73.8,46.6,83.3,84.7,78.3,72.6,76.7,88.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P14859-1","POU domain, class 2, transcription factor 1 [OS=Homo sapiens]",11,5,13,5,743,76.4,6.81,49.24,"other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","POU2F1","ENSG00000143190","Herpes simplex virus 1 infection; Lipid and atherosclerosis","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Interleukin-4 and Interleukin-13 signaling; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression","Integrated cancer pathway",0.996,0.963,0.967,0.975,0.939,102.3,98.9,99.4,102.7,100.2,96.5,102.7,102.4,102.3,95,99,100.6,92.3,100,99.5,97.3,102.8,119,101.8,94.9,100.3,94.3,99.1,96.6,916.8,914.3,913.7,848.1,884.1,898.6,824.7,892.8,888.5,868.9,918.4,1062.7,908.6,847.6,895.6,842.4,885.3,862.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96JG6","Syndetin [OS=Homo sapiens]",20,14,29,14,964,111.1,6.2,93.7,"transport","cytosol;other cytoplasmic organelle","other molecular function","VPS50","ENSG00000004766","","","",0.996,0.99,0.972,0.995,0.955,101.2,100.5,98.7,101.6,101.1,97,101.1,99.7,100.8,99.7,100.2,100.2,98.4,101.9,98.2,107.2,99.3,101.2,96.6,100.7,103.8,93.1,96.7,101.2,2113.9,2085.4,2108.6,2084.1,2096,2095.2,2057.7,2131.9,2054.2,2241.3,2076,2116.7,2019.4,2106.5,2170.4,1946.9,2021.7,2115.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6Y288","Beta-1,3-glucosyltransferase [OS=Homo sapiens]",3,2,4,2,498,56.5,7.5,7.17,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","B3GLCT","ENSG00000187676","Other types of O-glycan biosynthesis","Defective B3GALTL causes PpS; O-glycosylation of TSR domain-containing proteins","",0.997,0.954,1.06,1.03,1.062,98,93.8,104.2,98.3,101.3,104.4,99.1,100.2,110,91.5,95.8,100.8,103.1,106.4,109.8,101.6,100.5,56.2,97.5,103.5,107.6,102.3,106.7,107.4,506.8,512.5,562.9,467.8,490,515.8,527.5,544.5,561.5,519.7,513.9,287.7,498.7,529.5,550.6,523.1,545.7,549.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q13459-1","Unconventional myosin-IXb [OS=Homo sapiens]",17,28,49,28,2157,243.2,8.75,145.25,"signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function","MYO9B","ENSG00000099331","","RHOA GTPase cycle; RHOC GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOB GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHOF GTPase cycle; SLIT2:ROBO1 increases RHOA activity","Vitamin D receptor pathway",0.997,1.049,0.986,1.021,0.995,98.9,104,97.8,99.2,101.3,98.7,97.8,100.2,97.2,99.4,103.1,102.8,99,96.7,96.5,98,93.9,124.8,100.1,96.8,100.4,97.6,98.6,97.1,3916.3,4014.1,3894.1,3980,4126.9,4118.5,3963.2,3872,3866,3926.2,3758.7,4996.2,4008.9,3875.2,4019.6,3908,3947.5,3888.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q13177","Serine/threonine-protein kinase PAK 2 [OS=Homo sapiens]",47,18,112,15,524,58,5.96,327.9,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","PAK2","ENSG00000180370","MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Axon guidance; Focal adhesion; T cell receptor signaling pathway; Regulation of actin cytoskeleton; Pathogenic Escherichia coli infection; Human immunodeficiency virus 1 infection; Renal cell carcinoma","RHOV GTPase cycle; FCERI mediated MAPK activation; Regulation of activated PAK-2p34 by proteasome mediated degradation; MAPK6/MAPK4 signaling; RHOU GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Smooth Muscle Contraction; Nef and signal transduction; Generation of second messenger molecules; Regulation of PAK-2p34 activity by PS-GAP/RHG10; CDC42 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Ephrin signaling; Sema3A PAK dependent Axon repulsion; RHO GTPases activate PAKs; VEGFR2 mediated vascular permeability; Activation of RAC1; RHOH GTPase cycle; CD209 (DC-SIGN) signaling; CD28 dependent Vav1 pathway; Stimulation of the cell death response by PAK-2p34","Integrin-mediated cell adhesion; Apoptosis-related network due to altered Notch3 in ovarian cancer; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; 3q29 copy number variation syndrome; Malignant pleural mesothelioma; Regulation of actin cytoskeleton; ErbB signaling pathway",0.998,0.994,0.994,0.991,0.983,100.5,100,100.1,100.7,99.7,99,100.8,100.3,100.1,104.9,99.9,98.9,99.2,100,101.5,100.5,102.6,94.9,101.9,99.6,98.8,99.8,97.6,98.8,14847.7,14782,14747,15449.6,14712.6,14567.1,14610.2,14724.2,14945.8,14806.7,15107.1,13977.1,15014.5,14669,14557.5,14705.2,14383.5,14555.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O43242","26S proteasome non-ATPase regulatory subunit 3 [OS=Homo sapiens]",57,29,211,29,534,60.9,8.44,648.47,"protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","enzyme regulator activity","PSMD3","ENSG00000108344","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Interleukin-1 signaling; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease",0.999,1.023,1.011,1.015,1.029,98.6,101,99.8,98.7,100.2,101.6,98,98.7,98.2,100.6,104.5,100.4,99.4,98.4,101.4,100.5,97.2,98.4,99.7,99.8,101,101.2,101.2,101.3,19527.7,19670,19563,20037,20809.6,20003.9,19807.3,19602,20195,20029,19359.3,19592,19869.9,19888.1,20123,20150.9,20159.1,20184.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q12933","TNF receptor-associated factor 2 [OS=Homo sapiens]",19,10,19,10,501,55.8,7.53,51.72,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","TRAF2","ENSG00000127191","MAPK signaling pathway; NF-kappa B signaling pathway; Sphingolipid signaling pathway; Protein processing in endoplasmic reticulum; Apoptosis; Necroptosis; Osteoclast differentiation; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; IL-17 signaling pathway; TNF signaling pathway; Adipocytokine signaling pathway; Non-alcoholic fatty liver disease; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Hepatitis C; Human cytomegalovirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Viral carcinogenesis; Small cell lung cancer; Lipid and atherosclerosis","Ub-specific processing proteases; Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; TRAF6 mediated NF-kB activation; TNFR1-induced proapoptotic signaling; TRAF6 mediated IRF7 activation; Defective RIPK1-mediated regulated necrosis","RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Apoptosis; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Oxidative damage response; p38 MAPK signaling pathway; Nonalcoholic fatty liver disease; Small cell lung cancer; 16p11.2 proximal deletion syndrome; 16p11.2 distal deletion syndrome; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Malignant pleural mesothelioma; Alzheimer's disease",0.999,1.016,1.014,1.025,1.008,98.9,100.6,100.3,99,101.5,99.7,98.4,96,98.5,103.2,100.2,99.5,96.5,102.2,99.9,98.5,95.5,112.3,95.2,101,104,99.3,98.7,100.9,1947.7,1899.3,1948.2,2042.2,1981.8,1969.1,1910.4,2023.2,1976.4,1949.8,1889.2,2222.1,1884.1,1999,2058.8,1964.7,1953.5,1997.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q5VZK9","F-actin-uncapping protein LRRC16A [OS=Homo sapiens]",27,31,62,31,1371,151.5,7.85,173.54,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","CARMIL1","ENSG00000079691","","Factors involved in megakaryocyte development and platelet production","",1,0.99,1.021,1,0.998,99.8,98.9,102,99.9,99.8,99.6,100.1,97.5,100,102.1,95.7,99,103.9,102.1,101.5,100,104.1,92.3,99.7,100,100.4,99.4,99.8,102.5,6780.1,6605.6,6775.4,6919.1,6481.8,6709.8,7036.7,6919.5,6874.1,6777.8,7053.7,6256.2,6754.1,6774.6,6801.4,6737.8,6761.1,6945.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P23434","Glycine cleavage system H protein, mitochondrial [OS=Homo sapiens]",39,3,11,3,173,18.9,4.88,37.11,"protein metabolism;other metabolic processes","mitochondrion;other cell component","other molecular function","GCSH","ENSG00000140905","Glycine, serine and threonine metabolism; Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism","Glycine degradation","",1,0.96,1.003,0.991,1.014,100.6,96.5,100.9,100.5,99.6,102,103.4,102.1,101.6,97.9,97.2,100.9,107.3,102.4,94.4,102.1,102.3,65.4,105.8,101.1,99.8,103.5,109.6,103.2,943.3,931.7,926.8,893.7,887.3,920.9,979.4,934.6,861.1,931.4,933.5,597,965.4,922.8,910.7,944.6,1000.2,942.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q969M1","Mitochondrial import receptor subunit TOM40B [OS=Homo sapiens]",5,2,6,2,308,33.9,7.24,24.12,"cell organization and biogenesis;transport","other membranes;mitochondrion;other cell component","transporter activity;other molecular function","TOMM40L","ENSG00000158882","Amyotrophic lateral sclerosis; Pathways of neurodegeneration","","",1.001,0.997,1.089,1.062,1.073,96.5,96.1,105.1,96.4,102.4,103.5,96.4,93.5,90.5,93,92.5,98.5,98.6,101.7,105.1,83.3,93.4,168,91.4,100.8,99.2,90.8,100.2,103.1,390.1,378,366,376.3,374,398.4,398.9,411.4,424.9,336.9,377.6,679.3,369.7,407.8,401,367.2,405.3,417.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6VMQ6","activating transcription factor 7-interacting protein 1 [OS=Homo sapiens]",5,3,5,3,1270,136.3,4.7,9.45,"DNA metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","ATF7IP","ENSG00000171681","","PKMTs methylate histone lysines","",1.001,1.119,0.865,0.88,0.863,104.9,117.2,90.6,104.7,92.2,90.4,101.5,104.7,123.2,89.9,117,125.7,94.4,87.4,90.5,119.9,104.6,92.9,91.6,92,96.3,90.3,92.7,85.3,102.4,105.7,124.4,90.7,118.1,126.9,95.3,88.2,91.3,121,105.6,93.8,92.5,92.9,97.2,91.1,93.6,86.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y295","developmentally-regulated GTP-binding protein 1 [OS=Homo sapiens]",50,16,71,15,367,40.5,8.9,221.39,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","cytoskeletal activity;other molecular function","DRG1","ENSG00000185721","","","",1.002,0.989,1.003,1.003,1.012,100.1,98.8,100.2,99.8,100.2,101,104.2,97.6,99.8,98.2,100.7,98.5,97.9,99.9,101.5,105.1,99.5,96.6,99.8,101.6,99.6,100.7,100.8,98,8279.4,7756.7,7928.4,7804.3,7999.5,7826.1,7776.4,7935.1,8063.4,8356.1,7909.4,7679.6,7934.6,8075.7,7916.1,8001.3,8011.6,7792,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96RP9-2","Isoform 2 of Elongation factor G, mitochondrial [OS=Homo sapiens]",36,27,167,1,770,85.8,7.18,456.78,"","","","GFM1","","","","",1.003,1.019,0.976,1.01,0.999,100.2,101.7,97.5,99.9,100.9,99.8,100.8,99.3,100.3,96.4,102.1,101.9,97.7,96.9,97.6,100,96.2,104.4,99.9,101,103.3,99.9,99.8,102.2,18435.3,18154.8,18340.9,17629,18664.8,18626.6,17866.9,17711.4,17844.2,18287.8,17582.5,19092.1,18263,18471.6,18885.4,18267.6,18242.3,18676.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P48163","NADP-dependent malic enzyme [OS=Homo sapiens]",31,13,54,13,572,64.1,6.13,156.68,"other metabolic processes;other biological processes","cytosol;mitochondrion","other molecular function","ME1","ENSG00000065833","Pyruvate metabolism; Metabolic pathways; Carbon metabolism; PPAR signaling pathway","PPARA activates gene expression; Pyruvate metabolism","Nuclear receptors meta-pathway; NRF2 pathway; PPAR signaling pathway; Clear cell renal cell carcinoma pathways; TCA cycle in senescence",1.004,1.018,0.998,1.027,1.018,99.4,100.7,98.7,98.9,101.6,100.7,104.5,98.7,99.4,100.3,102.9,100.7,100.1,98,98.8,106.4,99,87,99.7,101.6,103.9,100.9,97.4,100.7,5427.3,5127.4,5162.8,5208.5,5345,5231.1,5199,5087.8,5129.2,5523.8,5140.7,4519.9,5179,5277.6,5395.8,5238.7,5060.5,5231.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96GJ1","tRNA (uracil(54)-C(5))-methyltransferase homolog [OS=Homo sapiens]",8,3,4,3,504,56.4,8.81,11.45,"RNA metabolism OR transcription;other metabolic processes","","other molecular function","TRMT2B","ENSG00000188917","","","",1.005,1.047,0.993,0.947,0.992,100.8,105,99.5,100.3,95,99.5,107.6,84,92.7,75.7,101.5,96.6,91.6,94.5,84.2,92.2,83,252.2,87.4,81.9,105.4,81.2,96.9,91.5,83.9,65.5,72.3,59,79.2,75.3,71.4,73.7,65.7,71.9,64.7,196.6,68.1,63.8,82.2,63.3,75.5,71.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H0U4","ras-related protein Rab-1B [OS=Homo sapiens]",83,15,110,6,201,22.2,5.73,318.85,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","RAB1B","ENSG00000174903","Legionellosis","COPI-mediated anterograde transport; COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs; COPI-dependent Golgi-to-ER retrograde traffic; RAB geranylgeranylation; Golgi Cisternae Pericentriolar Stack Reorganization","",1.005,1.028,1.102,1.097,1.072,95.7,97.8,104.9,95.2,104.4,102.1,89.8,99.7,95.5,106.8,94.9,97.7,106.8,103.6,104.7,88,100.5,95,104.2,108.9,98.8,101.9,99.2,104.1,5089.5,5651.9,5413.1,6055.3,5376.2,5535.3,6051.1,5871.4,5932.2,4986.7,5698.4,5384,5905.6,6170.2,5597.2,5774.1,5622.1,5901.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q5ST30-1","Valine--tRNA ligase, mitochondrial [OS=Homo sapiens]",12,11,21,11,1063,118.4,7.02,65.56,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;mitochondrion","other molecular function","VARS2","ENSG00000137411; ENSG00000223494","Aminoacyl-tRNA biosynthesis","Mitochondrial tRNA aminoacylation","",1.006,1.016,1.016,1.018,0.996,99.8,100.7,100.7,99.1,100.9,98.8,94.1,97.7,96.2,96.4,99,97.1,98.9,93.9,97.1,95.6,93.8,156,97.3,97.1,99.7,93,95.3,101.8,1839,1908.7,1880,1883.5,1934.2,1897.8,1933.3,1833.9,1898,1868.3,1832.2,3048.2,1901.5,1898,1948.3,1816.6,1861.3,1988.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P09132-1","Signal recognition particle 19 kDa protein [OS=Homo sapiens]",17,1,2,1,144,16.1,9.85,3.67,"cell organization and biogenesis;transport","cytosol;translational apparatus;nucleus;other cell component","translation activity;nucleic acid binding activity","SRP19","ENSG00000153037; ENSPPAG00000037062; ENSPTRG00000017136","Protein export","SRP-dependent cotranslational protein targeting to membrane","",1.006,0.91,0.906,1.011,1.116,101.5,91.7,91.4,100.8,102,112.6,101.8,81.8,104,93.9,92,85.5,108,91.6,75.9,101.1,93.9,161.9,81.2,102.3,117.3,75.5,119.5,112.9,30.1,24.2,30.7,27.8,27.2,25.3,31.9,27.1,22.4,29.9,27.8,47.8,24,30.2,34.7,22.3,35.3,33.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BVK2-1","Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase [OS=Homo sapiens]",5,2,4,2,526,60,9.14,10.37,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","ALG8","ENSG00000159063","N-Glycan biosynthesis; Metabolic pathways","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG8 causes CDG-1h","",1.008,1.206,1.098,1.154,1.041,92.9,111.2,101.2,92.2,106.4,96,92,93.8,96.4,97.1,120.9,112.2,92.4,106.8,102.2,76.7,93.1,100.9,87.9,107.4,110,96.2,96.9,117,200.7,204.6,210.3,211.8,263.6,244.8,201.5,233,222.9,167.4,203.1,220.2,191.8,234.3,240,209.9,211.4,255.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9P1F3","Costars family protein ABRACL [OS=Homo sapiens]",16,1,4,1,81,9.1,6.29,10.97,"other biological processes","","","ABRACL","ENSG00000146386","","","",1.008,0.892,0.863,0.893,0.977,107.4,95,91.9,106.5,95.1,104.1,110.6,112.9,92.8,97.8,65,142.9,81.5,107,94.6,109.6,134.6,22.1,97.9,99.8,88.8,107.2,149.4,85.5,148.1,151.3,124.3,131,87.1,191.4,109.2,143.3,126.7,146.9,180.3,29.5,131.1,133.7,118.9,143.5,200.1,114.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q5VIR6-4","Isoform 4 of Vacuolar protein sorting-associated protein 53 homolog [OS=Homo sapiens]",26,17,47,17,832,94.3,6.7,140.26,"transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","VPS53","ENSG00000141252; ENSG00000283883","","Retrograde transport at the Trans-Golgi-Network","",1.009,1.006,1.016,1.012,1.01,100,99.7,100.7,99.1,100.3,100.2,100.9,96.2,100,99.7,103.4,96.5,100.7,101.2,100.5,99.6,99.1,99.1,100,100.3,102,100.1,100.1,100.8,3906.8,3726.5,3871.6,3860.7,4003.1,3738.1,3898.5,3917.8,3891.6,3855.7,3837.7,3836.5,3870.8,3883.4,3951,3877.2,3877.8,3902.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P61960","Ubiquitin-fold modifier 1 [OS=Homo sapiens]",51,3,7,3,85,9.1,9.31,21.99,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","ER/Golgi;nucleus;other cell component","","UFM1","ENSG00000120686","","","",1.009,0.953,0.895,0.866,0.991,106,100.1,94,105,91,104,106.3,108.5,105.5,100.4,93.6,117,92.9,94.3,101.5,114.2,105.4,58.5,101.7,91.3,91.1,104.4,118,95.5,1834.3,1872.2,1820,1731.8,1614,2017.6,1602.8,1626.3,1750.6,1969.7,1817.7,1010,1754.2,1574.5,1571,1800.9,2035.5,1647.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O14802","DNA-directed RNA polymerase III subunit RPC1 [OS=Homo sapiens]",22,26,44,25,1390,155.5,8.48,120,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR3A","ENSG00000148606","RNA polymerase; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","Pyrimidine metabolism; Cytosolic DNA-sensing pathway",1.01,1.031,0.998,1.022,0.99,100.1,102.2,99,99.2,101.3,98.1,100.4,100.9,100,102.4,103.8,98.6,99.3,99.1,100,99.4,100,98.2,101.6,100.9,101.6,99.2,96.2,98.4,4655.1,4682.2,4637.1,4751.8,4815.2,4573.6,4603.6,4597.7,4637.9,4610.6,4636.6,4556,4710.9,4681.5,4712.3,4599,4462.6,4563,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O75396","Vesicle-trafficking protein SEC22b [OS=Homo sapiens]",38,7,51,7,215,24.6,6.92,195.73,"","","","","","","","",1.011,1.062,1.038,1.02,1.005,98.8,103.9,101.5,97.8,99.7,98.2,96.9,100.3,98.9,104,105,100.3,102.4,101.6,101.6,92.5,97.9,101,99,99.8,100.5,97.3,98.3,102.5,4504.8,4662.1,4598.7,4833.3,4881.8,4660.1,4760.8,4723.8,4720.8,4298,4549.9,4692.3,4601,4639.9,4672.6,4524.3,4570.6,4766.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P23378","Glycine dehydrogenase (Decarboxylating), mitochondrial [OS=Homo sapiens]",26,18,53,18,1020,112.7,7.11,173.42,"cell organization and biogenesis;other metabolic processes;other biological processes","plasma membrane;other membranes;mitochondrion;nucleus;other cell component","other molecular function","GLDC","ENSG00000178445","Glycine, serine and threonine metabolism; Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism","Glycine degradation","",1.011,1.024,1.029,1.021,1.031,99.2,100.5,101,98.1,100.1,101.1,98.2,99.3,102.6,100.6,100.8,95.9,102.8,100.5,101.1,98.2,100.9,92.5,101.7,100.3,99.5,100.7,101.3,103,5411.9,5474.9,5653.9,5545.8,5559,5284.9,5668.8,5542.4,5573.1,5415,5560.5,5098.7,5607.2,5527.7,5485.5,5550.6,5582.9,5680.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P18031","Tyrosine-protein phosphatase non-receptor type 1 [OS=Homo sapiens]",46,18,62,18,435,49.9,6.27,198.79,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","PTPN1","ENSG00000196396","Adherens junction; Insulin signaling pathway; Insulin resistance; Chemical carcinogenesis","MECP2 regulates neuronal receptors and channels; Growth hormone receptor signaling; Regulation of IFNG signaling; Regulation of IFNA signaling; Negative regulation of MET activity; Integrin signaling; PTK6 Down-Regulation","Leptin signaling pathway; Prolactin signaling pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Insulin signaling",1.012,1.057,1.001,1.013,0.991,99.9,104.4,98.9,98.8,100.1,97.8,96.7,98.7,100.3,103.1,108.1,101.1,105.1,97.7,96.6,96.9,97.6,110.4,99.1,98.1,98.9,96.6,95.7,99.3,7971,8134.1,8264.2,8494.9,8903.9,8331.8,8656.6,8050.2,7956.2,7986.6,8039.4,9097.7,8162.1,8079.8,8147.7,7963.2,7882.5,8184.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P17706-1","Tyrosine-protein phosphatase non-receptor type 2 [OS=Homo sapiens]",14,6,16,6,415,48.4,8.29,43.29,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus","signal transduction activity or receptor binding;other molecular function","PTPN2","ENSG00000175354; ENSGGOG00000010259","JAK-STAT signaling pathway","Negative regulation of MET activity; Interleukin-37 signaling","Immune response to tuberculosis",1.012,1.059,0.978,1.002,0.977,100.7,105.4,97.3,99.5,99.7,97.3,101.7,97.1,100.9,98.1,105.6,108.2,97.4,97.8,96.8,111.5,99.7,93.3,98.4,99.9,101.8,96.6,97.9,97.4,1660.4,1586.3,1647.3,1602,1724.3,1767,1591.1,1596.3,1580.2,1820.2,1627.7,1522.9,1606.2,1631.3,1662.5,1576.6,1598.8,1590.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P31930","Cytochrome b-c1 complex subunit 1, mitochondrial [OS=Homo sapiens]",53,19,131,18,480,52.6,6.37,405.78,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","UQCRC1","ENSG00000010256","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly",1.013,1.025,1.03,1.024,1.022,99.4,100.6,101.1,98.1,100.5,100.3,100.2,97.5,97.5,98.7,99.9,93.4,103.5,98.2,99.2,96.3,93.3,126.5,98.5,102.8,98.6,98.4,96.6,101.1,12395.5,12063.3,12057,12209.8,12364.2,11551.1,12807.9,12145.8,12267.3,11910.1,11542.8,15654.8,12182.6,12712.5,12194.9,12177.7,11950.7,12509.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q12767","Transmembrane protein 94 [OS=Homo sapiens]",4,4,5,4,1356,151.1,6.44,15.36,"","other membranes","","TMEM94","ENSG00000177728","","","",1.014,1.065,1.035,1.061,1.038,97.9,102.9,99.9,96.6,102.5,100.2,88.3,95.1,99.4,97,100,105.7,97.1,96.5,107.7,93.8,92.6,137.8,96.5,99.6,100.6,96,99,97.4,289,311.2,325.2,317.5,327.1,346,317.7,315.7,352.3,307,303,450.9,315.8,325.9,329.2,314.2,323.8,318.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P43487","Ran-specific GTPase-activating protein [OS=Homo sapiens]",22,5,15,5,201,23.3,5.29,39.53,"transport;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","RANBP1","ENSG00000099901","Human T-cell leukemia virus 1 infection; Viral carcinogenesis","Rev-mediated nuclear export of HIV RNA","22q11.2 copy number variation syndrome",1.015,1.173,2.071,1.602,1.035,77.1,89.1,157.4,76,121.8,78.6,75.2,68.4,117.8,100,87,77.4,163.1,129.1,153.6,82.7,74.2,64.9,118.8,84.8,143.8,111.6,76.7,70.9,1085.5,987.6,1699.8,1443.1,1255,1117,2353.1,1862.2,2216,1193,1069.9,936.8,1714.5,1222.9,2074.3,1611,1107.2,1022.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8N5C1","Protein FAM26E [OS=Homo sapiens]",4,1,1,1,309,35.1,8.13,2.41,"transport","plasma membrane;other membranes","transporter activity","CALHM5","ENSG00000178033","","","",1.015,1.058,1.143,1.081,0.964,97.3,101.4,109.6,95.8,103.5,92.4,89.9,95.4,96.5,99.3,104.7,90.8,105.8,126.4,107.4,97,93.9,92.2,119.6,101.5,98.9,90.6,103.4,86.7,55.4,58.8,59.4,61.2,64.5,55.9,65.2,77.9,66.2,59.8,57.9,56.8,73.7,62.5,61,55.8,63.7,53.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O75832","26S proteasome non-ATPase regulatory subunit 10 [OS=Homo sapiens]",54,9,38,9,226,24.4,6.1,130.27,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","PSMD10","ENSG00000101843","","Degradation of DVL; Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Parkin-ubiquitin proteasomal system pathway",1.016,0.965,0.921,0.913,1.008,104.7,99.5,94.9,103,94.1,103.8,99.4,101.4,95.7,86.2,94.5,97.4,90.2,86.6,97.5,97.9,90,190.6,94.6,89.4,89.4,98.7,104,96.4,3957.6,4037,3810.1,3431.4,3760.8,3876.3,3588.8,3444.6,3880.6,3896.7,3581.6,7583.3,3765.9,3557.4,3558.3,3926.2,4137.2,3837.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9ULW0","Targeting protein for Xklp2 [OS=Homo sapiens]",27,16,20,16,747,85.6,9.23,46.53,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","TPX2","ENSG00000088325","","AURKA Activation by TPX2; Regulation of TP53 Activity through Phosphorylation","Gastric cancer network 1",1.016,0.999,1.232,1.334,1.095,91.3,89.8,110.7,89.9,119.9,98.4,88.4,84,129.6,95.7,86.9,85,107.1,114.4,98.9,105,86.8,87,117.9,104.4,116,119.3,95.2,78.5,1956.1,1859.9,2869.5,2117.8,1923.1,1880.6,2371.2,2531.4,2189.3,2323.3,1922.2,1924.9,2610.6,2310.9,2568.3,2641.3,2108.1,1737.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UHD1","cysteine and histidine-rich domain-containing protein 1 [OS=Homo sapiens]",47,12,49,12,332,37.5,7.87,133.06,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","","other molecular function","CHORDC1","ENSG00000110172; ENSG00000285023","","","",1.017,1.009,0.994,1.011,1.008,101.1,100.2,98.8,99.3,100.5,100.1,102.4,100.5,103.5,100.5,101.6,106.4,97.4,100.1,100.7,100.7,101.3,64.3,101.8,101.7,109,100.9,105.7,101.5,6272.6,6154.7,6339.2,6151.5,6219.8,6513.1,5964.1,6130.4,6167.9,6165.3,6203.4,3936.4,6235.3,6226.6,6671.3,6176.6,6471.7,6211.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BYD1","39S ribosomal protein L13, mitochondrial [OS=Homo sapiens]",37,6,27,6,178,20.7,9.16,91.39,"protein metabolism;other metabolic processes;other biological processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL13","ENSG00000172172","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1.018,0.983,0.969,1.03,1.024,101.4,97.9,96.6,99.6,102.6,102,103,100.6,100.9,100,96.3,97.5,96.1,94.9,99.7,97.6,99.2,102.4,102.1,105.6,101.7,101.5,99.1,101.9,3190.8,3116.4,3127,3099.9,2982.8,3020.5,2978.3,2940.8,3089.5,3025.2,3072.7,3171.9,3164,3272.8,3150.4,3145.5,3069.7,3156.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q7L5Y9-1","Macrophage erythroblast attacher [OS=Homo sapiens]",16,5,9,5,396,45.3,8.69,22.91,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","MAEA","ENSANAG00000036521; ENSCATG00000019101; ENSCSAG00000015589; ENSG00000090316; ENSGGOG00000004866; ENSMMUG00000008357; ENSMNEG00000028551; ENSRBIG00000041870; ENSRROG00000043340","","","Ciliary landscape",1.018,1.062,0.986,1.006,0.911,102.1,106.5,98.9,100.3,100.9,91.4,99.7,100.6,105.9,104.9,111,104.9,95.4,97.4,101.4,98.8,93.2,105.9,99.4,102.5,97.8,90,89.3,101.8,876.1,883.9,930.8,921.7,975,921.7,838.2,855.9,891.3,867.9,819.2,930.2,873,900.7,859.1,791,784.3,894.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H3S7","Tyrosine-protein phosphatase non-receptor type 23 [OS=Homo sapiens]",20,27,56,27,1636,178.9,6.92,172.73,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PTPN23","ENSG00000076201","","Interleukin-37 signaling","",1.019,1.044,0.987,1.001,0.965,101.6,104.1,98.4,99.7,99.9,96.2,101.3,100.1,98.1,100.7,105.6,102.6,96.9,96.1,98.1,98.2,95.2,125.7,98.3,98.3,100.9,94.7,93.7,95.5,5931.2,5858.8,5743,5898,6181.1,6004.8,5675.7,5625,5743.4,5749.2,5574.5,7359.2,5757.7,5755.3,5907.2,5547.5,5488.3,5594.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O75348","V-type proton ATPase subunit G 1 [OS=Homo sapiens]",7,1,1,1,118,13.7,8.79,1.8,"transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle","transporter activity;other molecular function","ATP6V1G1","ENSG00000136888","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis","Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Osteoclast signaling; Proximal tubule transport",1.02,1.229,0.979,0.913,0.939,100.7,121.3,96.6,98.7,90.1,92.6,99.1,91.7,101.3,119.3,124.9,111.9,95.1,117.2,95.1,86.9,97.1,119.3,84.2,88.7,102.2,77.5,91.2,97.3,177.6,164.3,181.6,213.8,223.8,200.6,170.4,210,170.4,155.7,174,213.7,150.9,158.9,183.2,139,163.4,174.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UGJ1","gamma-tubulin complex component 4 [OS=Homo sapiens]",12,5,9,5,667,76,6.65,36.99,"cell cycle OR cell proliferation;cell organization and biogenesis","cytosol;cytoskeleton;other cytoplasmic organelle","cytoskeletal activity","TUBGCP4","ENSG00000137822","","Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes","15q11.2 copy number variation syndrome",1.02,1.071,1.059,1.012,1.038,98.7,103.7,102.5,96.8,97.9,100.4,96.1,99.9,106.3,104.9,89.3,104.9,98.2,105.3,103.7,97.9,104.6,84.8,98.8,99,102.8,101.8,100.2,101.6,692,718.8,764.7,755.3,642.8,754.6,706.5,757.9,746.1,704.4,753.1,610.4,710.9,712.8,739.7,732.8,721.1,731.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O00743","Serine/threonine-protein phosphatase 6 catalytic subunit [OS=Homo sapiens]",33,9,31,9,305,35.1,5.69,93.67,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport","cytosol;mitochondrion;nucleus","other molecular function","PPP6C","ENSG00000119414","","Telomere Extension By Telomerase; COPII-mediated vesicle transport","",1.022,1.017,1.016,1.021,1.039,100.3,99.8,99.7,98.1,100.2,102,100.1,100.1,96.4,98.7,102.3,99.7,99.5,101.9,98.5,98,97.4,99.9,98.3,100,102.9,105.4,101.8,99.1,3836.5,3837,3692.5,3781.4,3917.9,3818.2,3813.1,3903.2,3773.7,3754.2,3731.2,3826,3768,3832.3,3943.9,4037.3,3901.9,3797.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q53R41","FAST kinase domain-containing protein 1, mitochondrial [OS=Homo sapiens]",9,6,9,6,847,97.3,7.74,20.64,"RNA metabolism OR transcription;other biological processes","mitochondrion","","FASTKD1","ENSG00000138399","","","",1.022,1.072,1.093,1.033,1.033,98.1,102.8,104.9,96,99.1,99.1,91.7,100.8,96.7,103.6,101.4,97.9,98.1,104,103.4,94.6,93,128.1,97.7,98,96.7,96.1,97.7,100.5,577.7,634.9,609.5,652.8,638.9,616.5,618.2,655.5,651.6,596.1,585.9,807.1,615.5,617.2,609.3,605.7,615.6,633,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6NVY1","3-hydroxyisobutyryl-CoA hydrolase, mitochondrial [OS=Homo sapiens]",48,16,63,16,386,43.5,8.19,177.78,"other metabolic processes","mitochondrion","other molecular function","HIBCH","ENSG00000198130","Valine, leucine and isoleucine degradation; beta-Alanine metabolism; Propanoate metabolism; Metabolic pathways; Carbon metabolism","Branched-chain amino acid catabolism","Amino acid metabolism",1.023,1.012,1.027,1.059,1.041,99.6,98.5,100,97.4,103.1,101.4,104.7,98.4,99.2,96.8,104.8,98.2,99.6,101.1,99.5,97,90.1,100.3,98.2,102.7,103.4,101,100.3,104.6,7159.1,6732.8,6788,6625.1,7172,6716.4,6816.3,6916.1,6805.5,6636.1,6160.3,6861.1,6716.6,7027.3,7070.5,6909.8,6860.8,7158.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P38646","Stress-70 protein, mitochondrial [OS=Homo sapiens]",64,45,951,44,679,73.6,6.16,2731.91,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","mitochondrion;nucleus;other cell component","other molecular function","HSPA9","ENSG00000113013","RNA degradation; Tuberculosis","Mitochondrial protein import; Regulation of HSF1-mediated heat shock response; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Cristae formation","Parkin-ubiquitin proteasomal system pathway",1.024,1,1.032,1.054,1.038,99.9,97.6,100.7,97.6,102.9,101.3,101,98.7,99.5,99.5,97.2,97.2,100.9,100.3,100.1,97.2,99.8,96.3,102.4,106,101.5,100.9,99.2,102.5,123123.3,120244,121219.5,121258.4,118406.9,118412.5,122922.6,122190.3,121984.9,118398.7,121570.4,117287,124782,129163.5,123671.2,122911.5,120867.5,124856,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NQX4","Unconventional myosin-Vc [OS=Homo sapiens]",7,10,16,5,1742,202.7,7.71,45.45,"cell organization and biogenesis;transport","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYO5C","ENSG00000128833","Pathogenic Escherichia coli infection","","",1.024,1.014,1.056,1.019,1.042,99.8,98.9,102.9,97.5,99.3,101.6,92.2,84.8,93.9,91.1,91.3,91.3,95.1,90.6,95.1,90,85.2,240.1,91.7,90.9,97,93.8,89.7,96.3,435.7,401.1,444.1,430.6,431.7,431.6,449.7,428.2,449.4,425.5,403,1134.9,433.7,429.6,458.4,443.4,424,455.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BXP2-1","Solute carrier family 12 member 9 [OS=Homo sapiens]",2,2,4,2,914,96,8.07,12.13,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes","transporter activity","SLC12A9","ENSG00000146828","","","",1.025,0.987,1.058,1.127,1.046,98.5,94.9,101.7,96.1,108.3,100.5,94.6,86.1,89.7,93.2,86.4,86.1,90.9,92.6,95.9,85.8,87.5,242.7,91.2,103.9,98.7,94.9,88.1,91.5,246.1,224,233.5,242.5,224.9,224.1,236.6,241.1,249.7,223.3,227.8,631.4,237.2,270.5,256.8,246.8,229.3,238.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y3T9","Nucleolar complex protein 2 homolog [OS=Homo sapiens]",24,16,48,16,749,84.9,5.62,133.65,"cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","other molecular function","NOC2L","ENSG00000188976","","Regulation of TP53 Activity through Phosphorylation","",1.025,1.04,1.001,0.993,1.005,101.4,102.9,99.1,98.9,98.2,99.4,103.4,102,102.5,98.8,104.9,104,95.6,101.7,100.1,107.9,99.9,76.9,99.2,98.1,104.7,98.7,100.4,101,5403.3,5328.6,5352.2,5162.2,5478.3,5429.8,4995.8,5313.1,5227.3,5637.9,5219.9,4016.2,5183.9,5122.6,5470.2,5156.2,5245.9,5276.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NPQ8","Synembryn-A [OS=Homo sapiens]",56,23,56,22,531,59.7,5.33,169.65,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","enzyme regulator activity;other molecular function","RIC8A","ENSG00000177963","","","",1.026,1.055,1.042,1.061,1.012,99.4,102.1,100.9,96.8,102.7,98,99.5,98.8,97.9,101.6,102.7,101.3,96.2,100.8,100.4,96.3,93.7,111.1,98.5,102.2,102.3,97.4,97.5,101.5,5458.1,5423.2,5374.3,5575.9,5637.3,5559.5,5278.1,5530.9,5508.4,5285.9,5142.1,6094.1,5406.3,5608,5613.1,5345.2,5350.6,5571.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P20042","Eukaryotic translation initiation factor 2 subunit 2 [OS=Homo sapiens]",69,30,194,30,333,38.4,5.8,618.32,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","EIF2S2","ENSG00000125977","","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; Response of EIF2AK4 (GCN2) to amino acid deficiency; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP","Translation factors; Brain-derived neurotrophic factor (BDNF) signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell",1.027,0.948,0.984,0.961,0.967,104.6,96.6,100.3,101.9,98,98.6,105.3,105.9,104.7,109.1,93.2,97.3,97,100.9,103.7,102.6,119,61.5,106,98.6,97.8,100.9,99.2,97.3,26644.3,26783.1,26494.1,27596.9,23564.7,24601,24540.3,25525.9,26243.5,25950.6,30100.1,15549.8,26803.3,24942.3,24746.8,25523.5,25100.1,24620.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O94903","Pyridoxal phosphate homeostasis protein [OS=Homo sapiens]",43,11,42,11,275,30.3,7.5,111.97,"","cytosol;other cell component","other molecular function","PLPBP","ENSG00000147471","","","",1.027,1.04,1.023,1.017,1.038,100.3,101.5,99.9,97.6,99.3,101.3,98.7,101.7,100,102.7,98.7,101.3,98.9,99.6,104.9,97.4,100.6,95.1,99,102.2,97.6,101.1,99.4,101.1,4481,4615.8,4539.3,4661,4480,4595.3,4488,4520.9,4761.5,4418.8,4563.5,4315.3,4493.3,4638.3,4429.5,4586,4511.7,4585.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96D31","Calcium release-activated calcium channel protein 1 [OS=Homo sapiens]",7,2,2,2,301,32.6,8.32,3.17,"transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol","transporter activity;other molecular function","ORAI1","ENSG00000276045","Calcium signaling pathway; cAMP signaling pathway; Platelet activation; Renin secretion; Aldosterone synthesis and secretion; Cortisol synthesis and secretion; Cushing syndrome; Primary immunodeficiency","Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Ion homeostasis; Elevation of cytosolic Ca2+ levels","Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); FGF23 signaling in hypophosphatemic rickets and related disorders; Calcium regulation in cardiac cells",1.028,0.889,0.869,0.849,0.847,112.5,97.3,95.1,109.4,92.9,92.7,117.7,98.6,115.1,97.2,99.5,104.3,101.8,97.3,84.8,111.9,93.2,116.1,87.6,104.2,95.1,80.7,94.8,100,76.6,64.2,74.9,63.3,64.8,67.9,66.3,63.3,55.2,72.9,60.7,75.6,57,67.8,61.9,52.6,61.7,65.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UQ13","Leucine-rich repeat protein SHOC-2 [OS=Homo sapiens]",14,6,12,6,582,64.8,8.46,36.19,"signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","SHOC2","ENSG00000108061","Ras signaling pathway","RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling","Ras signaling; 22q11.2 copy number variation syndrome",1.029,1.078,1.002,0.999,1.001,101.1,105.9,98.4,98.2,98.1,98.3,98.8,101,99.8,103.4,110,104.5,96.9,97.1,103.3,96.9,91.1,120.4,94.3,99.1,96.8,97,92.3,97.5,1407.4,1439.3,1421.1,1472.8,1566.4,1487.9,1379.6,1383,1470.9,1380.4,1296.9,1714.9,1343.3,1411,1378.5,1382.2,1314.3,1388.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q13769","THO complex subunit 5 homolog [OS=Homo sapiens]",24,18,51,18,683,78.5,6.87,129.46,"RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","THOC5","ENSG00000100296","Nucleocytoplasmic transport","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","",1.03,1.003,0.991,1.02,0.993,102.3,99.7,98.5,99.4,101.4,98.7,104.9,100.7,102.6,99.9,97.9,100,102.1,96.6,98.8,99.9,97.3,99.6,100.6,101.6,102.2,98.9,99.4,97,5385.4,5172,5268.3,5132,5027.4,5135.9,5245.7,4959.8,5072,5127.9,4999,5116,5167.3,5217,5249.5,5079.5,5104.4,4980.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8NDF8-5","Isoform 5 of Non-canonical poly(A) RNA polymerase PAPD5 [OS=Homo sapiens]",11,6,11,6,698,75.8,9.38,26.2,"","","","TENT4B","","","","",1.03,1.003,1.03,0.999,1.016,101.7,99,101.7,98.7,98.6,100.3,102.8,105.1,100.2,104.8,100.1,93.4,106.1,100.8,102.8,106.1,99.8,75.9,99.7,103.6,97.5,101.5,96.2,103.6,1143.8,1168.6,1114.6,1165.4,1113.5,1039.1,1179.7,1121,1143.5,1180.2,1110.2,844,1109.3,1151.8,1084.9,1128.4,1070.3,1152.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NUU7","ATP-dependent RNA helicase DDX19A [OS=Homo sapiens]",49,21,55,4,478,53.9,6.58,145.47,"other metabolic processes;transport","nucleus;other cell component","nucleic acid binding activity;other molecular function","DDX19A","ENSG00000168872","Nucleocytoplasmic transport; mRNA surveillance pathway","","",1.031,1.047,1.04,1.046,1.044,99.6,101.2,100.5,96.7,101.1,100.9,101.1,100.2,100.2,102.6,96.2,101.8,101.1,100.7,101.6,97.2,98.9,91,102.6,101.5,101.7,102.6,101.5,97.3,7375.3,7310.7,7314.8,7488.6,7023.8,7431.5,7379.5,7352.3,7417.4,7095.5,7217,6640.4,7488.6,7411.1,7421.6,7487.7,7405.2,7104.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q09028","Histone-binding protein RBBP4 [OS=Homo sapiens]",47,15,89,1,425,47.6,4.89,315.29,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RBBP4","ENSG00000162521","Cellular senescence","Activation of anterior HOX genes in hindbrain development during early embryogenesis; HCMV Early Events; Potential therapeutics for SARS; Deposition of new CENPA-containing nucleosomes at the centromere; Oxidative Stress Induced Senescence; HDACs deacetylate histones; PRC2 methylates histones and DNA; Defective pyroptosis; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Transcriptional Regulation by E2F6; G1/S-Specific Transcription; Regulation of PTEN gene transcription; Regulation of TP53 Activity through Acetylation; PKMTs methylate histone lysines; RNA Polymerase I Transcription Initiation; Polo-like kinase mediated events; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1","Retinoblastoma gene in cancer; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; Malignant pleural mesothelioma",1.032,1.031,0.964,1.049,0.943,102.9,102.8,96,99.7,104.6,94,108,105.4,104.7,112.3,105.3,87.8,89.9,98.4,106.2,102.1,121.3,56.2,113.3,96.4,107.1,96.3,89.8,99.3,932.7,909.9,904.4,970.1,909.4,758.3,776,849.6,917.2,881.7,1047.6,485.2,978.4,832.5,925.1,831.5,775.6,857.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9ULA0","Aspartyl aminopeptidase [OS=Homo sapiens]",50,16,66,16,475,52.4,7.42,209.63,"","","","","","","","",1.033,1.076,1.079,1.051,1.048,98.5,102.7,103,95.4,100.3,100,98.6,99.4,97.8,102.3,102.8,103.5,99.1,103.1,104.2,95.5,92.8,96.6,98.9,100.4,104.8,100.7,99.5,100.1,5349.5,5392.6,5306.7,5548.3,5574.6,5613.6,5374.7,5591.3,5653.4,5180.9,5032.5,5241.9,5363.4,5447.4,5682.3,5460,5396.5,5431.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H0F7","ADP-ribosylation factor-like protein 6 [OS=Homo sapiens]",30,5,6,5,186,21.1,8.54,17.06,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","other molecular function","ARL6","ENSG00000113966","","BBSome-mediated cargo-targeting to cilium","Ciliopathies",1.033,1.05,0.99,0.999,1.059,101.1,102.8,96.9,97.9,97.8,103.6,105.5,98.5,103.2,91.3,104.9,105.6,101.3,97.1,98.8,109.6,99.9,63.6,100.4,98.1,99.8,104.5,112,105.8,640.3,597.8,625.8,554.1,636.3,640.9,614.7,589.2,599.6,664.9,605.8,386,609.3,595,605.2,634,679.2,641.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q92562","Polyphosphoinositide phosphatase [OS=Homo sapiens]",8,7,9,7,907,103.6,6.92,21.13,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","FIG4","ENSG00000112367","Inositol phosphate metabolism; Metabolic pathways; Amyotrophic lateral sclerosis; Pathways of neurodegeneration","Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane","Intracellular trafficking proteins involved in CMT neuropathy",1.033,1.134,1.116,1.076,1.105,95.9,105.3,103.6,92.8,99.9,102.5,95.5,96.4,96.7,102,105.8,105.9,99.7,104.1,105.9,98.9,93.3,85.4,103.8,97.7,100.4,102.1,103.4,103,851.6,859.7,862.8,909.6,943.7,944.4,889.4,928.3,944.1,882,832,761.6,925.6,871.2,895.3,910.7,921.9,919,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O43819","Protein SCO2 homolog, mitochondrial [OS=Homo sapiens]",41,9,41,9,266,29.8,8.85,136.52,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","other membranes;cytoskeleton;mitochondrion","other molecular function","SCO2","ENSG00000284194","Central carbon metabolism in cancer","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","",1.034,1.016,0.999,1.014,1.014,102.1,100.3,98.7,98.7,100.1,100.1,101.2,99.8,100.5,100.5,98.7,96.8,97.1,95.3,98,97.2,93.3,130.1,98.5,96.2,98.7,98.3,98.5,101.5,3018.2,2977,2996.4,2995.6,2943.7,2886.9,2895.2,2842.9,2921.9,2897.6,2781.2,3879.4,2936.7,2867.8,2943.3,2930.7,2938.2,3026.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O14681","Etoposide-induced protein 2.4 homolog [OS=Homo sapiens]",2,1,3,1,340,38.9,9.72,5.03,"other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus","other molecular function","EI24","ENSG00000149547","p53 signaling pathway","","miRNA regulation of p53 pathway in prostate cancer; Genotoxicity pathway",1.035,1.088,1.13,1.098,1.046,97.1,102.1,106,93.8,103,98.1,86.4,100.6,92.3,97,106.1,91.4,100.8,97.9,101.3,86.8,89.1,160.8,97.9,106.7,95.6,93.3,92.7,103.5,379,441.2,404.8,425.7,465.6,400.8,442,429.6,444.3,380.7,391.1,705.4,429.6,468,419.4,409.2,406.9,454,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P63010-1","AP-2 complex subunit beta [OS=Homo sapiens]",40,33,138,16,937,104.5,5.38,419.6,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","Ap2b1; AP2B1; LOC101351101; LOC111151383","ENSCANG00000036768; ENSCATG00000031381; ENSCGRG00001020053; ENSCGRG00015011838; ENSCJAG00000014853; ENSECAG00000009033; ENSFCAG00000010390; ENSG00000006125; ENSLCNG00005017201; ENSMMUG00000006048; ENSMNEG00000042752; ENSPPAG00000031208; ENSPTRG00000009021; ENSRBIG00000031992; ENSRNOG00000061543; ENSRROG00000030200; ENSSTOG00000002031; ENSUMAG00000016846","Endocytosis; Synaptic vesicle cycle; Endocrine and other factor-regulated calcium reabsorption; Huntington disease","MHC class II antigen presentation; Potential therapeutics for SARS; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; Retrograde neurotrophin signalling; MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; LDL clearance; Recycling pathway of L1; WNT5A-dependent internalization of FZD4; VLDLR internalisation and degradation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Retrograde neurotrophin signalling; Trafficking of GluR2-containing AMPA receptors; LDL clearance; Nef Mediated CD4 Down-regulation; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation","Synaptic vesicle pathway; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; mBDNF and proBDNF regulation of GABA neurotransmission",1.036,1.084,1.05,1.019,1.031,99.9,104.6,101.3,96.5,98.3,99.4,101.1,100.3,100.9,101.9,106.3,105.6,100.2,102.6,102.3,101.3,97.4,81.4,97.8,99.3,100.6,100.4,99.2,101.5,4888.2,4853.1,4877.7,4928.6,5141.1,5108,4847.9,4961.5,4945.4,4898.3,4710.4,3936.2,4729.3,4800.2,4865.8,4855.2,4796.6,4910.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8NEZ5-1","F-box only protein 22 [OS=Homo sapiens]",19,7,18,7,403,44.5,7.03,50.27,"protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton","other molecular function","FBXO22","ENSG00000167196","Salmonella infection","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","Genotoxicity pathway",1.036,1.086,1.029,0.973,1.048,100.7,105.6,100,97.2,94.6,101.9,104.3,94.6,99.5,101.3,104.3,108.6,94.8,102.6,98.8,96,83.6,120.4,93.4,93.1,102.2,100.7,102.3,99.5,1651.8,1497.9,1575.2,1603.8,1651.8,1720,1501.4,1623.9,1563.9,1520.4,1323.9,1905.7,1479.3,1474.3,1619,1594,1620.2,1575.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96GX5-1","Serine/threonine-protein kinase greatwall [OS=Homo sapiens]",11,8,9,7,879,97.3,5.99,20.21,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","MASTL","ENSG00000120539","","MASTL Facilitates Mitotic Progression","",1.036,1.003,1.009,1.027,0.966,102.9,99.6,100.3,99.3,101.9,96,101.9,102.5,95,98.6,88.1,103,92.8,99.2,100.2,95.1,98.3,143.9,90.1,106.7,100.9,95.5,95,93.3,639.8,643.7,596.6,619.1,553.4,646.6,582.7,623.2,629.2,597,617.3,903.7,566,670,633.7,599.8,596.5,586.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q06830","peroxiredoxin-1 [OS=Homo sapiens]",61,12,198,9,199,22.1,8.13,556.89,"cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PRDX1","ENSG00000117450","Peroxisome; Amoebiasis","Detoxification of Reactive Oxygen Species; TP53 Regulates Metabolic Genes; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models","Androgen receptor signaling pathway; Selenium micronutrient network; Nuclear receptors meta-pathway; NRF2 pathway",1.037,0.955,0.953,0.96,1.011,105.2,96.9,96.7,101.4,97.4,102.5,104.5,105.2,102.5,96.3,92.4,105,96.1,94.5,98.5,102.8,98.3,100.8,99.6,96.8,94.9,101.9,108.3,101.6,25553.4,25719.8,25066.1,23534.5,22590.9,25680,23495.6,23098.9,24071.8,25134.1,24043.1,24642.2,24353,23668.2,23214.2,24903.6,26485.9,24845.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P13716-1","Delta-aminolevulinic acid dehydratase [OS=Homo sapiens]",31,6,13,6,330,36.3,6.79,53.93,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","non-structural extracellular;cytosol;other cell component","other molecular function","ALAD","ENSG00000148218","Porphyrin and chlorophyll metabolism; Metabolic pathways; Biosynthesis of cofactors","Neutrophil degranulation; Heme biosynthesis","Heme biosynthesis",1.038,1.099,1.06,1.076,1.014,99,104.9,101.1,95.4,102.7,96.8,94,94,96.3,105.1,97.8,99.6,96,94,96.9,86.9,90.6,187.1,93.1,97.6,97.5,89.6,91.8,92.3,777.9,777.6,797.2,869.7,809.1,823.9,794.2,777.6,802.2,718.8,749.4,1548.3,770.4,807.8,806.7,741.4,760,763.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96AA3","Protein RFT1 homolog [OS=Homo sapiens]",5,3,6,3,541,60.3,8.85,12.36,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport","other membranes;ER/Golgi","transporter activity","RFT1","ENSG00000163933","","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective RFT1 causes CDG-1n","",1.039,1.104,1.071,1.118,1.11,96.7,102.8,99.8,93.1,104.1,103.4,96.9,97.2,106.7,99.7,105.3,103.3,100.2,99.5,103.3,93.5,95.4,74.5,101.1,108.3,104.6,103.9,103,103.9,563.9,565.3,620.6,580.2,612.4,601.1,583.1,579,600.9,544.3,554.9,433.3,588,629.9,608.6,604.7,599.2,604.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O00330-1","Pyruvate dehydrogenase protein X component, mitochondrial [OS=Homo sapiens]",29,14,42,14,501,54.1,8.66,119.68,"other metabolic processes","mitochondrion;other cell component","other molecular function","PDHX","ENSG00000110435","Metabolic pathways","Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid","Amino acid metabolism",1.039,1.059,1.044,1.041,1.06,99.9,101.8,100.3,96.1,100.1,101.9,97.9,97.7,99.3,101.4,99.8,96.4,98,98.4,103.5,94.2,91.4,129.8,98.1,96.7,98.8,99.9,98.2,100.4,6301.1,6290,6393.6,6528,6422.9,6205.3,6308.1,6330.6,6664.7,6065,5880.9,8357.9,6313.9,6224.9,6359.5,6427.3,6324.1,6464.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q86VV8","Rotatin [OS=Homo sapiens]",1,2,5,1,2226,248.5,6.7,11.84,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes","cytoskeleton;other cell component","","RTTN","ENSG00000176225","","","",1.04,1.039,1.041,0.997,1.014,101.7,101.7,101.9,97.9,97.6,99.2,104.4,108.1,96.7,88.4,104.3,109.5,104.5,98.3,105.5,109.8,100.4,53.8,98.1,100.1,106.2,100.7,109.3,101.8,71.9,74.5,66.6,60.9,71.9,75.4,72,67.8,72.6,75.6,69.2,37.1,67.6,69,73.1,69.4,75.3,70.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O15254","Peroxisomal acyl-coenzyme A oxidase 3 [OS=Homo sapiens]",24,12,20,12,700,77.6,7.25,66.46,"other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle","other molecular function","ACOX3","ENSG00000087008","Fatty acid degradation; beta-Alanine metabolism; alpha-Linolenic acid metabolism; Propanoate metabolism; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Carbon metabolism; Fatty acid metabolism; PPAR signaling pathway; cAMP signaling pathway; Peroxisome; Alcoholic liver disease","Peroxisomal protein import; Beta-oxidation of pristanoyl-CoA","PPAR signaling pathway; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Omega-3 / omega-6 fatty acid synthesis",1.04,1.092,1.055,1.1,1.027,98.8,103.8,100.3,95,104.5,97.6,99.5,98.3,94.4,103.2,108.1,97.1,102.8,99.7,89.5,94.5,90.7,122.1,96.6,106.7,103.9,94.5,97,101.5,1190.1,1175.8,1129,1234.3,1293.5,1161.8,1229.7,1192.7,1070.3,1130.5,1084.8,1461.4,1156.3,1277.1,1243.3,1130.4,1160.6,1214.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q86TM6","E3 ubiquitin-protein ligase synoviolin [OS=Homo sapiens]",12,7,42,7,617,67.6,6.95,99.81,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","SYVN1","ENSG00000162298","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum","Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; ER Quality Control Compartment (ERQC); XBP1(S) activates chaperone genes","",1.041,1.128,1.11,1.114,1.063,96.7,104.9,103.2,92.9,103.6,98.8,91.3,97.4,95.4,103.4,104.6,101.8,105.2,101.7,100.3,91.6,90.1,104.2,101.5,102.1,114.1,96,97.4,101.8,2810.3,2999.6,2935.7,3183.3,3220.4,3133.9,3238.4,3132,3087.5,2821.2,2774.7,3206.2,3125,3144,3512.9,2955.2,2999.4,3132.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q14696","LRP chaperone MESD [OS=Homo sapiens]",43,9,42,9,234,26.1,7.78,134.98,"cell-cell signaling;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi","signal transduction activity or receptor binding;other molecular function","MESD","ENSG00000117899","","","",1.042,1.04,1.075,1.099,1.152,97.5,97.4,100.7,93.6,102.9,107.9,94.9,99.1,112.4,99,96.5,107.3,101.4,106,102.3,102.8,95.1,55.4,105.1,100.2,104.5,109.6,112.6,95.9,5010.4,5231.6,5937.1,5224.4,5093.7,5665.1,5355.5,5596.8,5400.1,5426.1,5022.1,2926.5,5547.6,5288.1,5516.9,5784.3,5945,5065.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P50453","Serpin B9 [OS=Homo sapiens]",23,8,17,7,376,42.4,5.86,47.05,"other biological processes","non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","SERPINB9","ENSG00000170542","Amoebiasis","","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway",1.043,1.079,1.039,1.074,1.098,98.8,102.2,98.4,94.7,101.8,104.1,95,99.4,99.1,102.5,103.7,96.4,98.7,102.3,97.2,95,89.4,107.5,102.1,102.9,98.4,104.8,104.4,101,853.6,893.5,890.4,921,932.2,865.7,886.9,919.2,873.1,853.9,803.4,966,917.4,924.4,884.5,941.7,938,907.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P29375-1","Lysine-specific demethylase 5A [OS=Homo sapiens]",5,8,14,7,1690,192,6.49,37.38,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","KDM5A","ENSG00000073614","","HDMs demethylate histones","",1.043,1.2,1.041,1.005,1.021,99.2,114.1,98.9,95.1,95.6,97.1,96,99.7,102.4,102,114.7,120.7,96.2,101,99.4,91.2,95.5,103.6,99.1,90.1,96,97.6,98.3,96.5,678.6,704.8,724.4,720.9,810.7,853.7,680.6,714.4,703,645.1,675.5,732.6,700.4,637.2,679,690,695,682.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P36507","Dual specificity mitogen-activated protein kinase kinase 2 [OS=Homo sapiens]",46,18,63,13,400,44.4,6.55,192.84,"protein metabolism;other metabolic processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;kinase activity;other molecular function","MAP2K2","ENSG00000126934","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Cellular senescence; Vascular smooth muscle contraction; VEGF signaling pathway; Apelin signaling pathway; Gap junction; Signaling pathways regulating pluripotency of stem cells; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Long-term potentiation; Neurotrophin signaling pathway; Long-term depression; Regulation of actin cytoskeleton; Insulin signaling pathway; GnRH signaling pathway; Estrogen signaling pathway; Melanogenesis; Prolactin signaling pathway; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Relaxin signaling pathway; GnRH secretion; Cushing syndrome; Growth hormone synthesis, secretion and action; Alzheimer disease; Pathways of neurodegeneration; Salmonella infection; Yersinia infection; Hepatitis C; Hepatitis B; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Endometrial cancer; Glioma; Prostate cancer; Thyroid cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer","Signaling by BRAF and RAF1 fusions; Uptake and function of anthrax toxins; Signal transduction by L1; RAF activation; MAPK1 (ERK2) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Negative feedback regulation of MAPK pathway; Signaling by MAP2K mutants","IL-5 signaling pathway; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Amyotrophic lateral sclerosis (ALS); Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Bladder cancer; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; IL-6 signaling pathway; Pathways affected in adenoid cystic carcinoma; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Ethanol metabolism production of ROS by CYP2E1; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Kallmann syndrome; Malignant pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; EPO receptor signaling; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling; Toll-like receptor signaling pathway",1.044,1.075,1.089,1.082,1.08,98.3,101.3,102.6,94.2,101.9,101.7,99.3,99.1,98.7,102,104.2,101.6,103.3,103.3,101,98.1,94.9,74.1,101.8,106.5,102.7,102.4,102.5,104.6,9019.5,8997,8964.2,9265.9,9460,9230.6,9383.8,9384.5,9172.8,8908.4,8616.1,6726.1,9249.2,9676.1,9325.2,9298.3,9305.5,9504.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O75330-1","Hyaluronan mediated motility receptor [OS=Homo sapiens]",36,25,38,24,724,84,5.83,108.57,"","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","HMMR","ENSG00000072571","ECM-receptor interaction","AURKA Activation by TPX2; Hyaluronan uptake and degradation","",1.044,0.994,0.96,0.949,0.904,107.1,102,98.4,102.6,97.3,92.7,108.6,107.7,102.5,104.2,102.5,99.7,96.6,99,101.5,98.6,103.1,105.2,100.2,94.5,97.8,93.2,93.8,91.4,4353.8,4318.4,4109.9,4176.5,4110.9,3996.7,3871.4,3968.8,4069.2,3954.1,4134.7,4218.1,4017,3788.6,3921.9,3735.8,3761.3,3664.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P21912","Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [OS=Homo sapiens]",50,14,70,14,280,31.6,8.76,194.92,"other metabolic processes","plasma membrane;other membranes;mitochondrion;nucleus","other molecular function","SDHB","ENSG00000117118","Citrate cycle (TCA cycle); Oxidative phosphorylation; Metabolic pathways; Carbon metabolism; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport; Citric acid cycle (TCA cycle)","Electron transport chain: OXPHOS system in mitochondria; Metabolic reprogramming in colon cancer; Nonalcoholic fatty liver disease; Mitochondrial complex II assembly; TCA cycle (aka Krebs or citric acid cycle)",1.045,1.001,1.018,1.004,1.046,102.6,98.3,99.9,98.1,98.6,102.6,103,104,103.8,99.4,88.8,100.5,102.3,98.5,101.1,99.3,106.5,80.2,103.6,99.7,97.5,103.8,109.6,98.5,9381.6,9469.1,9452,9055.6,8085.1,9152,9315,8969,9208.9,9044.1,9703.7,7302.1,9431.3,9083.3,8878.1,9457.2,9985.3,8967.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P53621-1","coatomer subunit alpha [OS=Homo sapiens]",54,57,294,57,1224,138.3,7.66,894.15,"transport;signal transduction","non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","COPA","ENSG00000122218","","COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic","",1.045,1.06,1.057,1.043,1.047,100.3,101.7,101.4,96,100.1,100.5,101.4,99.2,101,100.8,102.4,104.6,99.7,102.1,103,98.1,96.6,84.9,99.4,100.8,103.7,99.4,101.7,101.2,33891.4,33130.2,33739.4,33672.1,34216,34939.6,33319.9,34120.7,34404,32776.4,32277.1,28380.5,33217.8,33664.6,34638.5,33205.9,33988.2,33802.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O14578-4","Isoform 4 of Citron Rho-interacting kinase [OS=Homo sapiens]",5,9,11,9,2069,236.5,6.67,18.9,"","","","CIT","","","","",1.046,1.126,1.064,1.038,1.055,99.2,106.7,100.9,94.8,98.4,100,100,101.3,95.5,107.6,102.3,113.2,92.8,105.3,101.7,95.5,97.7,90,99.7,93,99.2,105.9,98.4,100.8,684.2,693.4,653.9,736.4,700.4,774.5,634.9,720.9,696,653.9,668.8,616.2,682.6,636.3,678.8,724.5,673.2,689.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q00169","Phosphatidylinositol transfer protein alpha isoform [OS=Homo sapiens]",59,18,42,14,270,31.8,6.55,107.06,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","transporter activity;other molecular function","PITPNA","ENSG00000174238","","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Role of second messengers in netrin-1 signaling","",1.047,1.024,1.025,0.985,1.066,102.2,99.9,100,97.6,96.2,104.1,107.1,104.4,102.8,100.8,102.1,103.1,95.9,102.2,106.4,103.6,99.7,57.4,102.9,98.2,97.4,106.3,107.6,102.2,5062.6,4934.1,4858.7,4765.6,4823.7,4871.8,4532.4,4828.2,5028.7,4894,4712.1,2711.5,4865,4642.8,4602.8,5023.7,5086.6,4828,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BV44","THUMP domain-containing protein 3 [OS=Homo sapiens]",9,6,15,6,507,57,6.37,44.86,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","THUMPD3","ENSG00000134077","","","",1.047,1.024,1.027,1.044,1.035,101.7,99.4,99.8,97.1,101.4,100.5,106.8,105.9,105,110.5,103.6,86.3,93.8,105.5,103.9,101.1,107.7,35.7,111.3,102.1,105.6,107.8,102.6,104.6,2108.2,2090.5,2071.6,2181,2043.4,1703.4,1850.7,2082.2,2050.1,1995.8,2124.5,704.2,2196.2,2015.1,2083.8,2127.5,2024.8,2064.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NYB0","Telomeric repeat-binding factor 2-interacting protein 1 [OS=Homo sapiens]",46,13,25,13,399,44.2,4.73,84.5,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TERF2IP","ENSG00000166848","","DNA Damage/Telomere Stress Induced Senescence; Meiotic synapsis; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Packaging Of Telomere Ends; Polymerase switching on the C-strand of the telomere; Removal of the Flap Intermediate from the C-strand; Telomere C-strand synthesis initiation; Telomere Extension By Telomerase","Splicing factor NOVA regulated synaptic proteins",1.049,1.004,1.008,0.993,0.986,104.2,99.8,100.1,99.3,98.7,97.9,101.3,104.1,103.5,105.4,99.2,93.5,98.1,99.5,105.9,98.7,119,91.7,98.1,92.5,98.5,98.2,97.3,95.4,3137.6,3227.4,3208.1,3266.3,3073.2,2896.8,3040.6,3083.5,3281.5,3059.6,3686.7,2842.3,3039.2,2867.6,3052.2,3043.9,3015.5,2955.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8NBP0-1","Tetratricopeptide repeat protein 13 [OS=Homo sapiens]",12,8,11,8,860,96.8,7.01,35.48,"","","","TTC13","ENSG00000143643","","","",1.049,1.101,1.114,1.107,1.106,97.2,102,103.2,92.6,102.5,102.4,96.8,100.3,96.7,101.5,101.8,100.7,105.9,102.8,100.9,92.2,88.9,97.8,102,106.7,101.4,102,98,103.6,776.6,805.3,776.4,814.7,817.3,808.1,849.6,824.8,809.5,740.2,713.4,785.3,819,856.3,813.6,818.4,786.6,831.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q5HYI8","Rab-like protein 3 [OS=Homo sapiens]",31,8,17,8,236,26.4,7.11,51.86,"transport;developmental processes;other biological processes","other cell component","other molecular function","RABL3","ENSG00000144840","","","",1.05,1.065,1.111,1.123,1.094,97.8,99.1,103.5,93.1,104.6,101.9,107.6,97.9,98.4,99.6,100.7,99.7,104.1,104.1,102.1,103.4,93.6,68.4,98.9,105.1,106,102.1,102.5,105.9,2786.2,2535.9,2546.8,2577.9,2606.9,2581.6,2694.8,2696,2644.6,2677.1,2424.7,1771.6,2561.2,2722.9,2744,2643.2,2653.7,2742.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6ZNC8-1","Lysophospholipid acyltransferase 1 [OS=Homo sapiens]",2,1,2,1,495,56.5,9.23,5.24,"other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","MBOAT1","ENSG00000172197","Glycerolipid metabolism; Glycerophospholipid metabolism; Metabolic pathways","Acyl chain remodelling of PS; Acyl chain remodelling of PE","Regulation of Wnt / B-catenin signaling by small molecule compounds",1.05,1.022,0.967,1.131,0.974,102.6,99.8,94.4,97.7,110.4,95.1,100,124.3,85.8,97.3,111.1,87.4,91.6,110.2,92,68.1,95.2,114.5,97.7,107.6,122.5,90.6,111.5,92.7,53.5,66.5,45.9,52.1,59.4,46.8,49,59,49.2,36.5,50.9,61.3,52.3,57.6,65.5,48.5,59.7,49.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P52848-1","Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 [OS=Homo sapiens]",1,1,1,1,882,100.8,7.97,2.16,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","NDST1","ENSG00000070614","Glycosaminoglycan biosynthesis; Metabolic pathways","HS-GAG biosynthesis","Metapathway biotransformation Phase I and II",1.052,0.888,0.87,0.969,0.795,113.2,95.6,93.6,107.6,104.3,85.6,101.2,83.3,109.4,85.4,87.9,76.1,75,83.7,93.2,87.2,96.2,335.2,81.3,93.2,94,76.4,82,59.4,35.8,29.5,38.7,30.2,31.1,26.9,26.6,29.6,33,30.9,34.1,118.7,28.8,33,33.3,27.1,29,21,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H2V7","Protein spinster homolog 1 [OS=Homo sapiens]",6,2,5,2,528,56.6,6.64,17.54,"transport","other membranes;mitochondrion","transporter activity","SPNS1","ENSG00000169682","","","16p11.2 distal deletion syndrome",1.053,1.092,1.118,1.114,1.094,97.6,101.3,103.7,92.7,103.3,101.5,105.8,97,91,100.6,102,98.8,104.6,102.6,103,86.2,92.1,110.5,99.5,102.6,106.8,92.4,100.8,103.6,397.2,364.3,341.9,378,383.2,371.1,392.8,385.2,387,323.9,346.1,414.8,373.5,385.5,401,346.9,378.7,389.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q13627-1","dual specificity tyrosine-phosphorylation-regulated kinase 1A [OS=Homo sapiens]",8,6,9,6,763,85.5,8.75,18.38,"protein metabolism;other metabolic processes;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;kinase activity;other molecular function","DYRK1A","ENSECAG00000024965; ENSG00000157540; ENSPTRG00000013901","","G0 and Early G1","T cell receptor and co-stimulatory signaling; Hedgehog signaling pathway",1.053,1.147,1.07,1.07,1.099,98.1,106.9,99.7,93.2,99.7,102.4,102.3,98.7,97.7,94.2,113.3,107.4,100.3,101,92.9,115,93.7,74.2,93.3,100.2,109.1,103.2,102.9,100.5,783.1,755.2,748.2,721.4,867,822.3,767.5,773.3,711.1,880.7,717,568.2,714.3,767.1,835.2,790.2,788,769.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UDR5","Alpha-aminoadipic semialdehyde synthase, mitochondrial [OS=Homo sapiens]",23,18,43,18,926,102.1,6.64,123.98,"other metabolic processes;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","AASS","ENSG00000008311","Lysine degradation; Metabolic pathways","Lysine catabolism","Vitamin B6-dependent and responsive disorders",1.054,0.986,1.059,1.061,1.067,101.6,95,102,96.4,102.2,102.8,103.8,98.6,101.1,101.1,90.6,94.6,97.7,101.6,104.2,92.3,95.9,104.9,103,101.8,100.9,103.7,101.7,102.4,4040.9,3839.9,3937.2,3935.4,3526,3682.1,3805,3954.1,4057.2,3593.9,3734.7,4085.3,4009.1,3961,3929.3,4035.4,3958.8,3984.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O96005-1","Cleft lip and palate transmembrane protein 1 [OS=Homo sapiens]",33,14,54,14,669,76,6.3,171.56,"developmental processes;other biological processes","plasma membrane;other membranes;other cell component","","CLPTM1","ENSG00000104853","","","",1.054,1.087,1.076,1.105,1.057,99.2,102.2,101.2,94,103.9,99.4,91.3,96.4,97.5,99.4,101.3,98.7,100,97.7,98.3,89.3,91.4,142.8,99,103.5,101,96.6,95.1,100.6,3461.2,3653.7,3695.4,3767.1,3841.5,3742,3790.5,3706.1,3728.3,3384.4,3465.6,5415.3,3755,3923.3,3830.4,3664,3607.5,3816.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NUQ2","1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [OS=Homo sapiens]",35,12,28,12,364,42,9.1,77.29,"other metabolic processes;developmental processes","other membranes;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","AGPAT5","ENSG00000155189; ENSG00000284980","Glycerolipid metabolism; Glycerophospholipid metabolism; Metabolic pathways; Phospholipase D signaling pathway","Synthesis of PA","Triacylglyceride synthesis",1.055,1.105,1.088,1.127,1.12,97.5,102.1,100.5,92.4,104.1,103.5,100,97,98.5,102.4,104,103.1,106,101.5,100.8,94.9,93.3,79.5,99.1,105.1,105.7,104.7,99.8,104.5,2833.4,2749.2,2790.6,2902,2947.2,2921.8,3005.2,2877.5,2857.6,2689.9,2644.4,2252.9,2809.8,2979.9,2996.7,2966.7,2829.4,2962,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q92621","Nuclear pore complex protein Nup205 [OS=Homo sapiens]",24,40,108,40,2012,227.8,6.19,340.9,"cell organization and biogenesis;transport","other membranes;cytosol;nucleus","other molecular function","NUP205","ENSG00000155561","Nucleocytoplasmic transport; Amyotrophic lateral sclerosis","ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; HCMV Early Events; SUMOylation of DNA replication proteins; Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; Postmitotic nuclear pore complex (NPC) reformation; SUMOylation of DNA damage response and repair proteins; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus","",1.056,1.079,1.088,1.076,1.096,99,101.3,102.1,93.8,101,102.8,99.3,99.2,99.1,101.4,101.5,99.9,101.9,102.6,102.2,94.3,93.9,93.3,101.1,101.5,100.9,101.4,102.9,103.5,11150.5,11134.7,11128.2,11384.5,11401.1,11215.6,11438.5,11520.4,11475.6,10585.9,10546.3,10472.9,11350.1,11398.2,11325.8,11389.4,11558,11626.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P00390","Glutathione reductase, mitochondrial [OS=Homo sapiens]",47,18,83,18,522,56.2,8.5,280.8,"other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion","other molecular function","GSR","ENSG00000104687","Glutathione metabolism; Metabolic pathways; Thyroid hormone synthesis; Diabetic cardiomyopathy","","Glutathione metabolism; Selenium micronutrient network; Nuclear receptors meta-pathway; NRF2 pathway; Amino acid metabolism; One-carbon metabolism and related pathways; Oxidative stress response; Vitamin D-sensitive calcium signaling in depression; Sulfation biotransformation reaction; Metapathway biotransformation Phase I and II",1.057,1.09,1.033,1.043,1.052,101,104.2,98.8,95.6,99.8,100.6,103.2,101.1,100.5,98.1,106,104.3,97.1,99.3,98.8,101,92.6,95.6,99.4,99.8,101.7,100.7,100.6,100.1,9747.8,9541.3,9492.3,9260.7,10012.5,9844.7,9169.7,9372.1,9326.9,9536.3,8739.1,9030.8,9382.7,9421.4,9606.5,9508.4,9502.5,9455.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q15738","sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating [OS=Homo sapiens]",62,19,69,19,373,41.9,8.06,202.74,"other metabolic processes;developmental processes;signal transduction","other membranes;ER/Golgi;other cell component","other molecular function","NSDHL","ENSG00000147383","Steroid biosynthesis; Metabolic pathways","Cholesterol biosynthesis","Cholesterol biosynthesis pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias",1.058,1.068,1.064,1.085,1.058,100.2,101.2,100.8,94.7,102.8,100.3,101.4,102.1,101.2,102.5,100.1,105.4,100.6,102,104.5,96.7,95.9,72.5,101.1,104.1,105,101.5,101.5,101.8,10397.9,10463.3,10373.6,10505.2,10259.9,10807.9,10309.5,10457.4,10713,9911.1,9831.8,7430.2,10368.3,10670,10765,10404.8,10403.3,10437.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P21399","Cytoplasmic aconitate hydratase [OS=Homo sapiens]",30,21,64,21,889,98.3,6.68,179.12,"other metabolic processes;transport;developmental processes;other biological processes","cytosol;mitochondrion;ER/Golgi;other cell component","nucleic acid binding activity;other molecular function","ACO1","ENSG00000122729","Citrate cycle (TCA cycle); Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids","Iron uptake and transport","Iron metabolism in placenta; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc)",1.059,1.074,1.066,1.06,1.05,100.7,102.2,101.3,95.1,100.8,99.9,100.9,100.8,102.2,103.2,100.5,102.4,101.6,101.3,101.6,100.3,95.3,85.8,101.1,100.9,101,102.8,98.5,100.1,6408.3,6400.1,6491.8,6555.1,6384,6502.3,6450.9,6432.4,6453.4,6371.1,6053.9,5449,6419,6407.7,6416.6,6529.7,6254.1,6358.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O14744","Protein arginine N-methyltransferase 5 [OS=Homo sapiens]",37,21,49,21,637,72.6,6.29,162.74,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","PRMT5","ENSG00000100462","","snRNP Assembly; RMTs methylate histone arginines; Regulation of TP53 Activity through Methylation","Transcription co-factors SKI and SKIL protein partners; Nitric oxide metabolism in cystic fibrosis",1.059,1.089,1.067,1.096,1.091,99.3,102.1,100,93.7,102.7,102.2,100.4,99.4,99.6,100.3,102.4,103.7,100.4,101,99.4,94.1,94,90.7,100.6,103.1,104.4,100.5,102.5,103.4,6654.3,6586.8,6602.1,6646.7,6790.8,6872.1,6653.7,6696.6,6590.8,6239.4,6233.2,6015.1,6667.5,6831.7,6922,6659.4,6797.3,6856.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9HBH1","Peptide deformylase, mitochondrial [OS=Homo sapiens]",13,3,4,3,243,27,9.16,11.61,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","other molecular function","PDF","ENSG00000258429","","","",1.059,1.002,0.951,1.037,0.979,105.4,99.7,94.7,99.5,103.2,97.4,100.1,107.6,93.6,99.3,94.7,94.7,96.1,85.9,89.9,93,94.5,182.5,99.2,98,95.4,88.7,94.1,92.5,447.5,480.8,418.3,443.7,423.1,423.1,429.4,383.8,401.8,415.6,422.4,815.5,443,438.1,426.4,396.3,420.6,413.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q5JUQ0","Protein FAM78A [OS=Homo sapiens]",7,1,1,1,283,31.9,8.06,4.56,"","","","FAM78A","ENSG00000126882","","","",1.06,0.95,0.873,1.055,0.897,109,97.6,89.8,102.8,108.5,92.3,151.1,86.5,99.6,67.3,102.8,89.2,78.9,82,95.7,93.9,88.3,226.3,100.5,79.6,99.1,80,94.8,84.3,45.1,25.8,29.7,20.1,30.7,26.6,23.6,24.5,28.6,28,26.4,67.5,30,23.8,29.6,23.9,28.3,25.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NX08","COMM domain-containing protein 8 [OS=Homo sapiens]",34,4,6,3,183,21.1,5.43,20.61,"","cytosol;nucleus","","COMMD8","ENSG00000169019","","Neddylation","",1.061,1.116,0.994,1.088,1.04,101,106.3,94.7,95.3,103.7,99,93.4,101.7,102,107,96.4,110.8,86.5,95.3,109.2,82.9,106,95.9,105.1,104.4,99.8,99.7,109.5,94.5,561.3,611,613.1,642.8,579.3,666,519.5,572.5,656,498,636.7,576.1,631.2,627.1,599.4,598.9,657.9,567.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P05165-1","Propionyl-CoA carboxylase alpha chain, mitochondrial [OS=Homo sapiens]",28,16,30,16,728,80,7.52,89.32,"other metabolic processes","cytosol;mitochondrion","other molecular function","PCCA","ENSG00000175198","Valine, leucine and isoleucine degradation; Glyoxylate and dicarboxylate metabolism; Propanoate metabolism; Metabolic pathways; Carbon metabolism","Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency; Propionyl-CoA catabolism","",1.062,1.072,1.057,1.104,1.063,100.2,101.2,99.8,94.4,104.2,100.3,98,99.5,99.6,100,102.6,100.5,103.1,98.8,99.1,93.7,91.6,104.9,98.3,103.5,103.6,99.6,99.5,104.2,2475.6,2514.1,2516.2,2527.7,2591.6,2538.8,2604.3,2497,2503.2,2367.7,2313.9,2650.3,2484.8,2614.2,2617.7,2516,2513.5,2632.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NPR9","Protein GPR108 [OS=Homo sapiens]",17,7,19,7,543,60.6,8.69,51.14,"other biological processes","other membranes;ER/Golgi","","GPR108","ENSG00000125734","","","",1.063,1.091,1.077,1.105,1.127,98.7,101.3,100,92.8,102.6,104.7,98.1,97.8,98.6,96.7,105.5,100.7,99.4,99,99.9,101.1,90.9,92.3,99.7,102,105.8,101.7,104.1,106.7,2457.5,2449.1,2470.3,2422.2,2643.7,2523,2490.5,2481.2,2501.4,2533.4,2277.6,2312.8,2497.1,2555,2649.1,2547.8,2607,2671.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P11169","Solute carrier family 2, facilitated glucose transporter member 3 [OS=Homo sapiens]",4,2,2,2,496,53.9,7.2,4.48,"other metabolic processes;transport","plasma membrane;other membranes;other cell component","transporter activity;other molecular function","SLC2A3","ENSG00000059804","","Neutrophil degranulation; Cellular hexose transport; Vitamin C (ascorbate) metabolism; MECP2 regulates neuronal receptors and channels","Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced HIF-1 survival signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K/AKT/mTOR - VitD3 signaling; Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis",1.063,0.888,0.933,0.876,0.911,112.4,94,98.7,105.8,92.7,96.4,101.8,115.2,106.9,86.6,106.6,89.4,111.6,85.6,93.8,90.5,100.6,163.2,88.2,100,84,91.7,81.4,103,139.7,158,146.7,118.8,146.2,122.6,153.1,117.4,128.7,124.1,138,223.9,120.9,137.1,115.2,125.8,111.6,141.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P17655-1","Calpain-2 catalytic subunit [OS=Homo sapiens]",56,31,129,30,700,79.9,4.98,403.65,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","CAPN2","ENSG00000162909","Protein processing in endoplasmic reticulum; Apoptosis; Necroptosis; Cellular senescence; Focal adhesion; Alzheimer disease; Pathways of neurodegeneration; Shigellosis","Degradation of the extracellular matrix; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models","Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Focal adhesion; VEGFA-VEGFR2 signaling pathway; Alzheimer's disease",1.063,1.105,1.13,1.1,1.103,98.1,101.9,104.3,92.3,101.5,101.8,98.5,99.4,100.1,104.4,103.3,102.5,101.7,106.6,105.7,94.5,93.5,74.1,102.8,100.9,102.9,103.2,102.1,103.8,13988.5,14114.2,14217,14826.5,14661.1,14552.9,14438.4,15131.9,15004,13419.2,13273.9,10513.2,14595.1,14318.4,14612.5,14646.2,14499.4,14733.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P26006","Integrin alpha-3 [OS=Homo sapiens]",1,1,1,1,1051,116.5,6.77,1.82,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","ITGA3","ENSG00000005884","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Hematopoietic cell lineage; Regulation of actin cytoskeleton; Human papillomavirus infection; Pathways in cancer; Small cell lung cancer; Hypertrophic cardiomyopathy; Arrhythmogenic right ventricular cardiomyopathy; Dilated cardiomyopathy","Integrin cell surface interactions; Laminin interactions; MET activates PTK2 signaling; Basigin interactions","Integrin-mediated cell adhesion; Arrhythmogenic right ventricular cardiomyopathy; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ebola virus pathway in host; Small cell lung cancer; Nephrotic syndrome; Genes controlling nephrogenesis; Malignant pleural mesothelioma",1.064,1.132,0.953,1.122,0.977,102.2,108.7,91.5,96,107.8,93.8,98.4,90.4,115.4,106.3,104.8,99.1,82.9,102.9,88.2,91.8,92.5,131.9,112.1,103.8,98.8,90.3,100,90.4,69.8,64.1,81.9,75.4,74.3,70.3,58.8,73,62.6,65.1,65.7,93.6,79.6,73.7,70.1,64.1,71,64.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8TD19","Serine/threonine-protein kinase Nek9 [OS=Homo sapiens]",14,11,19,11,979,107.1,5.74,58.2,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","kinase activity;other molecular function","NEK9","ENSG00000119638","","EML4 and NUDC in mitotic spindle formation; Nuclear Pore Complex (NPC) Disassembly; Activation of NIMA Kinases NEK9, NEK6, NEK7","Ciliopathies",1.065,1.092,1.087,1.025,1.088,100.5,103.1,102.6,94.4,96.8,102.7,96.5,95.6,103.5,97.3,103,99,97.3,101.4,98.5,90.6,82.9,155.6,92.6,92.9,98.4,92.7,103.7,98.6,1368.5,1356.7,1468.8,1380.4,1461.7,1404.2,1380.7,1438.6,1396.8,1285.5,1176.4,2207.4,1313.3,1318,1395.4,1314.6,1471.3,1398.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y371","Endophilin-B1 [OS=Homo sapiens]",28,12,35,11,365,40.8,6.04,97.7,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SH3GLB1","ENSG00000097033","Autophagy; Endocytosis","","Nanoparticle triggered autophagic cell death; Senescence and autophagy in cancer",1.065,1.07,1.092,1.047,1.048,101.1,101.6,103.6,94.9,99.3,99.4,105.7,103,100.8,107.8,103.4,103.3,103.2,105.6,105.7,104,96.7,55.1,101.2,103.2,99.4,102.1,98.6,101.3,3745.3,3650.5,3571.2,3822.7,3666.3,3660.5,3656.3,3741.4,3748.3,3687.5,3427,1953.7,3586.5,3659.2,3521.6,3620.2,3495,3590,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96K31-1","Uncharacterized protein C8orf76 [OS=Homo sapiens]",2,1,1,1,380,43.2,5.43,0,"","","","C8orf76","ENSG00000189376","","","",1.066,1.102,0.973,0.878,0.811,109.7,113.4,100.2,102.9,90.3,83.5,84.7,106.4,121.7,110,109.9,119.3,83.3,103.8,97.2,99.8,93.1,126.2,73.4,87.6,98.1,81,127.9,76.7,19.1,24,27.5,24.9,24.8,26.9,18.8,23.4,22,22.6,21,28.5,16.6,19.8,22.2,18.3,28.9,17.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q969Y2","tRNA modification GTPase GTPBP3, mitochondrial [OS=Homo sapiens]",21,7,18,7,492,52,6.48,67.37,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus;other cell component","other molecular function","GTPBP3","ENSG00000130299","","tRNA modification in the mitochondrion","",1.067,1.06,1.055,1.045,1.089,101.3,100.7,100.2,95,99.3,103.5,101.8,101.7,100.3,101.1,101.5,98.1,100.6,98,103.9,98,94.6,95.3,99.7,102.6,95.8,104.4,98.9,103.8,981.4,980.4,966.8,974.5,978.4,945.4,969.7,944.7,1001.7,945.1,912.1,919.3,960.9,989.1,924.1,1006.1,953.6,1001.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P30837","Aldehyde dehydrogenase X, mitochondrial [OS=Homo sapiens]",48,18,60,17,517,57.2,6.8,183.58,"other metabolic processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","ALDH1B1","ENSG00000137124","Glycolysis / Gluconeogenesis; Ascorbate and aldarate metabolism; Fatty acid degradation; Valine, leucine and isoleucine degradation; Lysine degradation; Arginine and proline metabolism; Histidine metabolism; Tryptophan metabolism; beta-Alanine metabolism; Glycerolipid metabolism; Pyruvate metabolism; Pantothenate and CoA biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Alcoholic liver disease","Ethanol oxidation","",1.067,1.073,1.108,1.095,1.087,99.6,100.2,103.4,93.3,102.1,101.4,101.2,97.9,100.6,103.1,101.2,100.3,102.1,104.5,105.8,94.2,94.6,78.9,101.4,103.1,103.8,102.4,99.2,105.5,7699,7454.2,7654.7,7850.2,7699.2,7636.3,7774.1,7949.8,8053.1,7172.4,7196.7,6005.3,7720.6,7850.3,7900.3,7795.7,7548.9,8029.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UJS0","Calcium-binding mitochondrial carrier protein Aralar2 [OS=Homo sapiens]",32,17,33,12,675,74.1,8.62,92.52,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes;mitochondrion","transporter activity;other molecular function","SLC25A13","ENSG00000004864","","Gluconeogenesis; Mitochondrial protein import; Aspartate and asparagine metabolism","",1.068,1.066,1.076,1.093,1.094,100.2,100,100.9,93.8,102.5,102.6,101.8,97.5,99.5,99.3,100.2,98.8,97.2,104.2,100.2,93.2,89,108.6,99.1,102.2,101.8,100.8,101.9,104.6,3160.6,3026.1,3089.6,3083.8,3110.3,3067.5,3016.7,3233.4,3111.7,2892.8,2763.3,3370.6,3076.8,3172.3,3160.8,3128.8,3163.6,3247.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P07384","Calpain-1 catalytic subunit [OS=Homo sapiens]",57,35,159,34,714,81.8,5.67,466.75,"protein metabolism;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","CAPN1","ENSG00000014216","Protein processing in endoplasmic reticulum; Apoptosis; Necroptosis; Cellular senescence; Alzheimer disease; Pathways of neurodegeneration; Shigellosis","Degradation of the extracellular matrix; Neutrophil degranulation; Formation of the cornified envelope; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models","Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Alzheimer's disease",1.069,1.131,1.108,1.071,1.11,98.9,104.5,102.5,92.5,99.1,102.6,96.5,99.8,99.1,102.4,104.8,104.7,101.3,102.8,102.7,93.5,92.7,91.7,99.3,97.7,103.1,103.1,102.1,102.8,16238.8,16779.2,16661.1,17227.2,17624.6,17618.9,17031.3,17284.9,17268.3,15734.6,15584.8,15426,16699,16429,17338.4,17348.1,17174.7,17296.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q4G0N4","NAD kinase 2, mitochondrial [OS=Homo sapiens]",30,11,24,11,442,49.4,8.18,77.01,"other metabolic processes","mitochondrion","kinase activity;other molecular function","NADK2","ENSG00000152620","Nicotinate and nicotinamide metabolism; Metabolic pathways; Biosynthesis of cofactors","Nicotinate metabolism","",1.07,1.177,1.136,1.075,1.151,97.1,106.9,103.1,90.8,97.6,104.5,93.9,98.6,97.4,93.8,107.7,107.2,103.6,103.5,102.4,91.1,87.9,99.4,97.9,96.7,104.8,103.8,105.4,104.9,2690,2825,2791.2,2685.6,3085.6,3071.8,2966.5,2964.5,2932.3,2609.2,2518.2,2848.1,2804.2,2769.9,3002.7,2973.4,3018.5,3003.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NVV0","Trimeric intracellular cation channel type B [OS=Homo sapiens]",16,3,7,3,291,32.5,9.06,14.93,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;nucleus","transporter activity;other molecular function","TMEM38B","ENSG00000095209","","","Type I collagen synthesis in the context of osteogenesis imperfecta",1.071,1.129,1.13,1.161,1.181,96.3,101.5,101.7,89.9,104.4,106.2,95.2,95.1,100.5,100.4,107.2,90.7,100.5,101.5,97.7,88.9,86.9,117.4,99,104.9,103.2,100.8,105.1,105,733.5,732.4,774.2,773,825.3,698.5,774.4,782.1,752.1,685,669,904,762.2,808.2,795.2,776.4,809.2,808.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8WZA9","Immunity-related GTPase family Q protein [OS=Homo sapiens]",43,19,48,19,623,62.7,4.88,152.13,"","","other molecular function","IRGQ","ENSG00000167378","","","",1.071,1.044,1.01,1.029,0.992,104.6,101.9,98.6,97.6,100.5,96.8,103.3,104.9,104.9,105.1,94.6,102.3,98.9,96.9,105,90.1,97.9,104.2,97.6,100.8,102.8,98.1,97.2,95.5,3497.5,3553.8,3553.7,3559.6,3203.9,3464.3,3349.2,3283.9,3557.6,3051.4,3317.5,3529.4,3307.3,3414.4,3481.6,3322.3,3291.3,3234.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96AG3","Solute carrier family 25 member 46 [OS=Homo sapiens]",15,3,7,3,418,46.1,7.43,23.85,"cell organization and biogenesis","other membranes;mitochondrion","","SLC25A46","ENSG00000164209","","","",1.072,1.117,1.042,1.068,1.027,101.7,105.9,98.8,94.8,101.3,97.4,96.4,100.5,104.1,103.6,104.7,108.8,97.7,95.1,103.4,91.6,93.7,111.7,100.1,98.2,101.8,98.5,94,96.3,599.4,624.8,647.5,644.5,651,676.4,607.3,591.6,643.1,569.4,582.8,694.4,622.6,610.7,633.1,612.6,584.4,598.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q92482-1","Aquaporin-3 [OS=Homo sapiens]",3,1,9,1,292,31.5,7.23,27.43,"stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;nucleus;other cell component","transporter activity;other molecular function","AQP3","ENSG00000165272","Vasopressin-regulated water reabsorption","Vasopressin regulates renal water homeostasis via Aquaporins; Passive transport by Aquaporins","Pre-implantation embryo",1.073,1.129,1.097,1.126,1.12,98.3,103.5,100.6,91.7,103.2,102.7,93.8,101.7,97.5,102.7,85.8,107.1,96.5,109.7,99.8,83.6,91,121.8,102.4,106.9,102.2,101.9,102.9,92.8,843.3,914.6,876.9,923.4,771.2,962.5,867.2,986.5,896.7,751.9,817.6,1094.7,920.4,960.6,918.4,915.7,924.8,834.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q5JPH6","Probable glutamate--tRNA ligase, mitochondrial [OS=Homo sapiens]",32,14,31,14,523,58.7,8.76,94.98,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion","nucleic acid binding activity;other molecular function","EARS2","ENSG00000103356","Porphyrin and chlorophyll metabolism; Aminoacyl-tRNA biosynthesis; Metabolic pathways; Biosynthesis of cofactors","Mitochondrial tRNA aminoacylation","",1.073,1.071,1.1,1.115,1.128,99.2,99,101.8,92.5,103.1,104.3,101,99.1,98.5,98.9,100.4,96,102.6,101.7,101.5,99.1,92.4,90.1,101.5,103.9,103,104.2,101.4,104.6,2779.1,2726.7,2709.9,2721.3,2760.6,2641.5,2823.3,2796,2792.3,2725.7,2540.7,2477.5,2791.5,2856.9,2833.8,2866.7,2789.1,2877.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NQC3-2","Isoform 2 of Reticulon-4 [OS=Homo sapiens]",32,7,53,7,373,40.3,4.78,192.59,"","","","RTN4","","","","",1.074,1.108,1.097,1.117,1.079,99.5,102.6,101.7,92.7,103.5,100,88.3,98.1,96,99,104.2,97.3,100.2,97.3,98.1,86.8,89.4,157.7,97.6,99.9,100.4,93.2,96.5,100,2443.5,2715.5,2658.9,2741.7,2885.3,2692.4,2775.1,2693.3,2715.6,2401.7,2475.5,4364.4,2702.6,2766.1,2780.3,2580.3,2670.2,2767.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6ZNJ1-1","Neurobeachin-like protein 2 [OS=Homo sapiens]",16,33,76,32,2754,302.3,6.38,212.79,"developmental processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi","other molecular function","NBEAL2","ENSG00000160796","","Neutrophil degranulation","",1.074,1.071,1.092,1.136,1.108,99.4,99.2,101.1,92.6,105.1,102.6,99.7,97.1,100.2,98.9,99.4,99.7,100.6,101.4,102,96.5,92.8,87.6,101,105.4,107.2,102.6,102.9,105,6216,6056.7,6249.1,6167.9,6199.5,6215,6271.9,6319.5,6356.3,6017.3,5786.4,5461.6,6295.3,6571.3,6682.8,6398.5,6412.5,6546.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y547","Intraflagellar transport protein 25 homolog [OS=Homo sapiens]",42,4,11,4,144,16.3,5.03,43.54,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","other molecular function","HSPB11","ENSG00000081870","","Intraflagellar transport","Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); GDNF/RET signaling axis",1.076,1.208,1.047,1.123,1.084,98.7,110.8,96.1,91.8,103.1,99.5,99.1,97.9,98.6,100.4,117.9,110.7,97.3,96,91.5,107.3,91.7,81.8,100.8,103,106.6,97.8,102.1,99.3,681.2,673.3,678.1,690.4,810.7,761.1,669.1,660.1,629.2,737.8,630.3,562.4,693.1,707.8,732.6,672.3,702,683,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UKV0-1","Histone deacetylase 9 [OS=Homo sapiens]",1,1,2,1,1011,111.2,6.89,3.71,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","other molecular function","HDAC9","ENSG00000048052","Neutrophil extracellular trap formation; Alcoholism; Viral carcinogenesis","Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway","MicroRNAs in cardiomyocyte hypertrophy; Neural crest differentiation; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; VEGFA-VEGFR2 signaling pathway; Ethanol effects on histone modifications; Sudden infant death syndrome (SIDS) susceptibility pathways",1.076,1.082,1.081,0.954,1.045,103.5,104,104,96.2,91.8,100.5,109.5,103.2,107.4,91.1,108,121,89.6,107.9,116.8,114.1,99.9,19.9,95.3,87.6,108.4,104.4,103.6,112.4,630.7,594.3,618.9,524.5,622.2,697.1,516,621.7,672.8,657.2,575.2,114.7,548.9,504.7,624.2,601.3,596.5,647.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q5T4S7-1","e3 ubiquitin-protein ligase UBR4 [OS=Homo sapiens]",24,98,284,98,5183,573.5,6.04,848.76,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus","other molecular function","UBR4","ENSG00000127481","Human papillomavirus infection; Viral carcinogenesis","Neutrophil degranulation; Antigen processing: Ubiquitination & Proteasome degradation","",1.077,1.098,1.079,1.059,1.053,101.5,103.5,101.7,94.3,99.8,99.2,101.4,100.9,101.3,102.7,105.1,103.3,101.3,101.6,101.5,94.1,92,98.5,98.9,99.6,100.3,99,98.7,99.8,25985.8,25852,25956.5,26298.4,26934.4,26454.3,25956.1,26022.9,25999.8,24102.5,23574.9,25234.9,25339.1,25516.6,25683.7,25371.9,25284.5,25559.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q32P44","Echinoderm microtubule-associated protein-like 3 [OS=Homo sapiens]",22,16,43,16,896,95.1,7.12,138.85,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity","EML3","ENSG00000149499","","","",1.078,1.071,1.078,1.06,1.087,101.5,100.8,101.5,94.1,99.8,102.3,100.9,97.5,100.7,99.4,103.9,100.1,100.7,101.8,98.3,93.4,90.5,103.5,97.8,99.1,106.3,100.1,101.6,104.4,4639.7,4483.1,4634,4571.3,4780.4,4603.8,4633.3,4684.6,4520.2,4297.9,4161.8,4762.8,4500.1,4557.7,4890.5,4602.6,4671.5,4801.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NWS8","Required for meiotic nuclear division protein 1 homolog [OS=Homo sapiens]",10,4,4,4,449,51.6,8.69,9.4,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","","RMND1","ENSG00000155906","","","",1.078,1.193,1.074,1.104,1.129,98.4,108.8,98,91.2,100.7,103,97.8,97.2,102,108.1,117.8,101.7,90.9,97.4,101,90.7,79.5,126.4,107.2,85.2,100.1,103.1,91.7,102.3,293.3,291.7,306.1,324.4,353.3,305.1,272.7,292.1,302.9,272,238.5,379.1,321.7,255.6,300.4,309.2,275.2,307,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P11586","C-1-tetrahydrofolate synthase, cytoplasmic [OS=Homo sapiens]",54,42,250,41,935,101.5,7.3,749.22,"","","","","","","","",1.08,1.053,1.091,1.101,1.087,101.1,98.5,102.1,93.6,103.1,101.7,101.9,100.8,101.6,100.5,97.7,99.1,100.5,102.6,103.2,94.6,94.1,87.5,103.8,103.7,102.9,102.3,100.9,102.3,28534.2,28222.5,28456.9,28152,27343.9,27735.5,28142.4,28740.1,28885.5,26491.1,26351.6,24508.2,29068.5,29023.6,28800.1,28631.7,28238.8,28656.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q16531","DNA damage-binding protein 1 [OS=Homo sapiens]",42,42,198,42,1140,126.9,5.26,554.88,"cell-cell signaling;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DDB1","ENSG00000167986","Nucleotide excision repair; Ubiquitin mediated proteolysis; Hepatitis B; Human immunodeficiency virus 1 infection; Viral carcinogenesis","Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER; Neddylation; Recognition of DNA damage by PCNA-containing replication complex; DNA Damage Recognition in GG-NER","Hippo-Merlin signaling dysregulation; Hepatitis B infection; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum",1.08,1.154,1.106,1.06,1.11,99.6,106.4,101.9,92.2,97.7,102.3,99.5,100,101.4,99.8,106.9,109.2,97.4,102.6,102.4,99.7,92.6,77.4,97.8,98.2,105.1,102.8,106.2,101,23045.7,23164.6,23471.7,23116.3,24748.6,25288.9,22562.9,23760.3,23714.5,23082.9,21448.9,17911.6,22646.6,22730.9,24332.4,23800.8,24585,23385.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H845","Acyl-CoA dehydrogenase family member 9, mitochondrial [OS=Homo sapiens]",44,29,107,29,621,68.7,7.96,350.49,"cell organization and biogenesis;other metabolic processes","other membranes;mitochondrion;nucleus;other cell component","other molecular function","ACAD9","ENSG00000177646","","Complex I biogenesis","Mitochondrial immune response to SARS-CoV-2",1.081,1.025,1.083,1.095,1.097,101.7,96.4,101.8,94,103,103.1,102,102.9,99,100.8,96.4,96.7,108,102.2,99.8,94.3,97.2,76.2,103.3,110.1,99.8,105.9,101.8,103.4,16148.3,16287.8,15662.8,15961.7,15264.8,15311.1,17099.1,16170.3,15795.1,14932.5,15386.1,12059.8,16354.4,17424.5,15796.4,16765.6,16113.2,16373.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P48506","glutamate--cysteine ligase catalytic subunit [OS=Homo sapiens]",20,10,18,10,637,72.7,6.09,57.43,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","cytosol;mitochondrion;other cell component","other molecular function","GCLC","ENSG00000001084","Cysteine and methionine metabolism; Glutathione metabolism; Metabolic pathways; Biosynthesis of cofactors; Ferroptosis","Glutathione synthesis and recycling; Defective GCLC causes HAGGSD","Glutathione metabolism; Trans-sulfuration and one-carbon metabolism; Aryl hydrocarbon receptor Netpath; Apoptosis-related network due to altered Notch3 in ovarian cancer; Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; One-carbon metabolism and related pathways; Oxidative stress response; Ferroptosis; NRF2-ARE regulation; Gamma-glutamyl cycle for the biosynthesis and degradation of glutathione, including diseases; Vitamin D-sensitive calcium signaling in depression; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway",1.082,1.111,1.1,1.055,1.032,101.7,104.5,103.4,94,99.2,97.1,105.2,101.1,99.1,102.5,111.4,103.8,102.8,101.2,102.8,93.5,88.3,94.6,98.6,101,98.4,95.9,96.5,103.3,1730,1662.9,1629.1,1686,1832.6,1707.5,1690.7,1663.9,1690.6,1537,1452,1556,1621.8,1661,1617.9,1576.2,1586.2,1697.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q29983","MHC class I polypeptide-related sequence A [OS=Homo sapiens]",3,1,1,1,383,42.9,6.98,2.44,"stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding","MICA","ENSG00000183214; ENSG00000235233","Natural killer cell mediated cytotoxicity; Kaposi sarcoma-associated herpesvirus infection","Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell","Allograft Rejection",1.083,0.856,0.91,0.979,1.024,111,87.8,93.3,102.5,100.4,104.9,93.9,119.3,113.5,93,89.7,77.3,102.3,95.4,76.9,125.4,104.8,80.4,102.6,98.5,119.6,107.3,92.8,107.4,29.2,37.2,35.3,28.9,27.9,24.1,31.8,29.7,23.9,39,32.6,25,31.9,30.7,37.2,33.4,28.9,33.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P07199","Major centromere autoantigen B [OS=Homo sapiens]",14,6,10,6,599,65.1,4.55,31.46,"","nucleus;other cell component","nucleic acid binding activity;other molecular function","CENPB","ENSG00000125817","","","IL-18 signaling pathway",1.083,1.113,1.112,1.1,1.096,99.9,102.7,102.6,92.2,101.5,101.1,99.5,100.3,99,102.2,108.6,99.5,102.2,101.8,104.1,93.2,91.9,89.9,101.1,96.6,107,100.7,95.2,107.2,863.9,870.4,859.8,887.6,943.3,863.7,886.9,884.2,903.6,809.2,797.5,780.9,877.7,839,928.8,874.3,826.8,930.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O00186","syntaxin-binding protein 3 [OS=Homo sapiens]",19,9,24,9,592,67.7,7.8,66.92,"cell adhesion;cell-cell signaling;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","STXBP3","ENSG00000116266","","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Disinhibition of SNARE formation","Insulin signaling",1.085,1.108,1.065,1.059,1.038,102.4,104.6,100.6,94.4,100,98,103.3,98.7,102.9,105.4,99.5,105.1,98.3,101.1,102.2,94.9,93.8,99.1,103.4,97.9,100.4,97,98.4,98.5,2358.6,2252.7,2348.5,2404.9,2270.7,2399.2,2243.6,2306.4,2331.9,2164.9,2140.5,2261.8,2360.6,2234.7,2292.2,2214.4,2246.2,2249.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BUQ8","Probable ATP-dependent RNA helicase DDX23 [OS=Homo sapiens]",37,33,98,32,820,95.5,9.55,276.36,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","other molecular function","DDX23","ENSG00000174243","Spliceosome","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","",1.086,1.059,1.092,1.084,1.061,102.1,99.6,102.6,94,101.9,99.7,106.5,100.5,102.2,99,103.7,99.7,102.8,102.7,99.8,97.5,94.1,83.7,100.3,103.7,102,99.8,99.7,102.2,12038.5,11361.3,11551.9,11190.9,11720.1,11264.9,11617.5,11608.7,11273.8,11019.2,10632.3,9462.8,11334,11723.2,11522.8,11281,11261.5,11547.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P16930","Fumarylacetoacetase [OS=Homo sapiens]",34,12,59,12,419,46.3,6.95,168.21,"other metabolic processes","cytosol","other molecular function","FAH","ENSG00000103876","Tyrosine metabolism; Metabolic pathways","Tyrosine catabolism","Amino acid metabolism",1.087,1.096,1.11,1.118,1.082,100.5,101.2,102.6,92.4,103.3,100,100.7,100.3,101.3,101.5,101.3,103.1,98.6,102.8,103.9,92.6,91.7,97.6,98.9,103.6,103.6,97.2,101,100.2,6271.8,6246.3,6305.2,6319.2,6304.4,6416.2,6140.5,6402.3,6470.8,5767.4,5712.4,6076.4,6155.9,6449.7,6451.9,6052.3,6289,6239.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P61160-1","Actin-related protein 2 [OS=Homo sapiens]",36,11,110,11,394,44.7,6.74,332.6,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","Actr2; ACTR2; LOC111147990","ENSAMEG00000015749; ENSANAG00000038066; ENSBIXG00000015264; ENSBIXG00005008678; ENSBTAG00000009761; ENSCAFG00000003197; ENSCATG00000036025; ENSCCAG00000030047; ENSCHIG00000014272; ENSCJAG00000006722; ENSCPOG00000025808; ENSDLEG00000013424; ENSECAG00000009219; ENSFCAG00000004960; ENSG00000138071; ENSHGLG00000013085; ENSLAFG00000010273; ENSLCNG00005006073; ENSMFAG00000044097; ENSMLEG00000038155; ENSMLUG00000005227; ENSMMUG00000002263; ENSMNEG00000044163; ENSMPUG00000006176; ENSMUSG00000020152; ENSNLEG00000009948; ENSOANG00000039143; ENSOCUG00000004906; ENSPANG00000007073; ENSPCOG00000025808; ENSPCTG00005007920; ENSPPAG00000030634; ENSPPYG00000012359; ENSPTRG00000011990; ENSRBIG00000040326; ENSRFEG00010007536; ENSRROG00000043956; ENSSBOG00000028028; ENSSSUG00005000856; ENSSTOG00000012608; ENSTSYG00000034470; ENSVURG00010013014; ENSVVUG00000027598","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Salmonella infection; Yersinia infection; Pathogenic Escherichia coli infection; Shigellosis","Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; EPHB-mediated forward signaling; Regulation of actin dynamics for phagocytic cup formation; Neutrophil degranulation; EPHB-mediated forward signaling; Clathrin-mediated endocytosis; RHO GTPases Activate WASPs and WAVEs","ESC pluripotency pathways; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways",1.089,1.118,1.1,1.088,1.089,100.7,103.5,101.8,92.5,100.7,100.8,98.3,100.7,101.4,104.2,102.9,103.5,100.3,101.8,104.1,92.3,92.5,93.5,100.7,100.5,100.8,100.8,102,99.7,14079.1,14426.9,14527.6,14926.5,14731.2,14819,14365.6,14577.1,14906.3,13217.8,13253.1,13396.9,14416.3,14397,14434.9,14430.7,14606.7,14276,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8WWI5","choline transporter-like protein 1 [OS=Homo sapiens]",19,12,26,12,657,73.3,8.6,65.94,"other metabolic processes;transport","plasma membrane;other membranes;cytosol;mitochondrion;nucleus","transporter activity","SLC44A1","ENSG00000070214","Choline metabolism in cancer","Synthesis of PC; Choline catabolism; Transport of bile salts and organic acids, metal ions and amine compounds","",1.09,1.157,1.168,1.164,1.107,97.8,103.8,104.8,89.7,104.5,99.3,96.9,97.8,97.1,105.1,103,102.7,104,105.6,103.5,89.1,88.7,97.1,101.1,103.8,103.7,98.6,98.2,103.9,2246.1,2266,2249.5,2436.8,2388,2381.2,2411.4,2448.1,2398.6,2064.3,2055.8,2251.4,2344.2,2405.2,2402.9,2285.1,2276.1,2407.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q7Z3B4","Nucleoporin p54 [OS=Homo sapiens]",31,14,38,14,507,55.4,7.02,111.66,"cell organization and biogenesis;transport;other biological processes","other membranes;nucleus","other molecular function","NUP54","ENSG00000138750","Nucleocytoplasmic transport; Amyotrophic lateral sclerosis","HCMV Early Events; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; Regulation of HSF1-mediated heat shock response; Transport of Mature mRNA derived from an Intron-Containing Transcript; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation","",1.09,1.017,1.073,1.082,1.09,103,96.1,101.4,94.5,102.2,102.9,105.1,102.4,107.6,103.8,96,98,101.6,103.4,104.2,96.4,98.1,59.7,104.3,103.4,105.1,105.9,100.3,105,3721.9,3625.6,3810.1,3676.1,3401.5,3471,3598.4,3662.5,3689.6,3413.3,3474.7,2113.4,3693.4,3660.9,3721,3749.7,3550.8,3719.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q86VR2","Reticulophagy regulator 3 [OS=Homo sapiens]",21,6,27,6,466,51.4,4.97,67.23,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;other cell component","","RETREG3","ENSG00000141699","","","",1.091,1.115,1.066,0.993,0.942,105.5,107.8,103.1,96.7,96,91,96.8,102.6,107.6,104.8,109.3,104.2,103.5,100.2,97.7,94,91.9,135.8,91,93.3,96.9,88.5,88.1,93.8,1802.5,1910.6,2004.6,1952.3,2036.8,1942,1927.4,1867.1,1820.6,1750.9,1712.5,2530.8,1694.5,1738.3,1804.7,1649,1641.3,1747.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UKS6","Protein kinase C and casein kinase substrate in neurons protein 3 [OS=Homo sapiens]",2,1,1,1,424,48.5,6.18,2.24,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","PACSIN3","ENSG00000165912","","Clathrin-mediated endocytosis","",1.092,1.085,1.053,1.015,1.026,104.5,103.8,100.8,95.7,97.1,98.1,103.7,109.5,102.8,89.1,103.1,111.2,111.6,91.7,100,95,116.6,77.5,94.9,99,96.4,95.9,97.4,104.7,113,119.3,112,97,112.3,121.1,121.6,99.9,109,103.5,127,84.5,103.4,107.9,105.1,104.5,106.2,114.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BQA1","Methylosome protein 50 [OS=Homo sapiens]",25,6,22,6,342,36.7,5.17,76,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","WDR77","ENSG00000116455","","RMTs methylate histone arginines; snRNP Assembly","",1.093,1.107,1.116,1.118,1.104,100.3,101.6,102.4,91.8,102.6,101.3,100,97.5,98.8,100,114.2,98.1,104.8,100.8,98.9,109.5,90.3,75.1,97.6,101,106.7,99.7,98.2,108.9,1638.6,1597.9,1618.9,1639.2,1871.8,1608.5,1717.4,1652.3,1621.1,1794.9,1480.5,1230.6,1600.2,1655.8,1748.6,1634.1,1609.8,1785.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P27986","Phosphatidylinositol 3-kinase regulatory subunit alpha [OS=Homo sapiens]",16,10,16,9,724,83.5,6.16,43.18,"cell adhesion;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","PIK3R1","ENSG00000145675","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; Platinum drug resistance; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Phosphatidylinositol signaling system; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Osteoclast differentiation; Focal adhesion; Signaling pathways regulating pluripotency of stem cells; Platelet activation; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; TNF signaling pathway; Leukocyte transendothelial migration; Neurotrophin signaling pathway; Cholinergic synapse; Inflammatory mediator regulation of TRP channels; Regulation of actin cytoskeleton; Insulin signaling pathway; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Prolactin signaling pathway; Thyroid hormone signaling pathway; Regulation of lipolysis in adipocytes; Relaxin signaling pathway; GnRH secretion; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Aldosterone-regulated sodium reabsorption; Carbohydrate digestion and absorption; Alzheimer disease; Spinocerebellar ataxia; Prion disease; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection; Chagas disease; Amoebiasis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Signaling by FGFR1 in disease; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; G alpha (q) signalling events; RAC1 GTPase cycle; VEGFA-VEGFR2 Pathway; RHOC GTPase cycle; CDC42 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; RAF/MAP kinase cascade; PI3K Cascade; PI-3K cascade:FGFR4; Signaling by FGFR4 in disease; Downstream TCR signaling; RND2 GTPase cycle; RHOF GTPase cycle; Extra-nuclear estrogen signaling; RHOV GTPase cycle; Signaling by ALK fusions and activated point mutants; RHOU GTPase cycle; Synthesis of PIPs at the plasma membrane; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Regulation of signaling by CBL; Nephrin family interactions; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; Costimulation by the CD28 family; CD28 dependent PI3K/Akt signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; RND3 GTPase cycle; RND1 GTPase cycle; Interleukin-4 and Interleukin-13 signaling; PI3K events in ERBB4 signaling; PI3K events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; GAB1 signalosome; Signaling by cytosolic FGFR1 fusion mutants; PI-3K cascade:FGFR1; PI-3K cascade:FGFR2; Signaling by FGFR2 in disease; PI-3K cascade:FGFR3; Signaling by FGFR3 point mutants in cancer; FLT3 Signaling; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FGFR3 fusions in cancer; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants; GP1b-IX-V activation signalling; MET activates PI3K/AKT signaling; Activated NTRK3 signals through PI3K; Activated NTRK2 signals through PI3K","IL-5 signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase (AMPK) signaling; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Apoptosis; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; IL-6 signaling pathway; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Ebola virus pathway in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Overview of interferons-mediated signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; IL-18 signaling pathway; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; Modulators of TCR signaling and T cell activation; Orexin receptor pathway; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; Interferon type I signaling pathways; Notch signaling pathway (Netpath); ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway",1.094,1.112,1.123,1.149,1.137,99.2,100.9,101.9,90.7,104.2,103.1,96.6,104.9,99,103.6,100.5,100.7,98.7,101.7,106.1,90.5,98.8,88.3,104.8,93.7,103.9,102.3,103,102.9,1577.3,1712.9,1615.6,1691.4,1641,1643.1,1611,1659.2,1731.5,1477,1613.2,1440.8,1710.4,1529.4,1696.6,1669.9,1680.9,1679.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96N46","Tetratricopeptide repeat protein 14 [OS=Homo sapiens]",7,5,6,5,770,88.3,8.63,13.69,"","","nucleic acid binding activity","TTC14","ENSG00000163728","","","Ectoderm differentiation; Ectoderm differentiation",1.095,1.084,1.151,1.243,1.137,97.9,96.9,102.9,89.4,111.1,101.7,97.5,98.1,101.8,110.3,97.1,97,93.6,103.1,106.4,89.5,101.9,66.1,111.3,92.9,121.9,101.8,97.5,112.3,424.6,427.1,443.5,480.2,422.7,422.4,407.5,448.8,463.5,389.9,443.7,287.7,484.6,404.6,530.8,443.5,424.7,488.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q93009","Ubiquitin carboxyl-terminal hydrolase 7 [OS=Homo sapiens]",62,57,211,57,1102,128.2,5.55,639.11,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","USP7","ENSG00000187555","FoxO signaling pathway; Epstein-Barr virus infection; Viral carcinogenesis","Ub-specific processing proteases; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Regulation of TP53 Degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Formation of TC-NER Pre-Incision Complex; Regulation of PTEN localization","Regulation of toll-like receptor signaling pathway; Nucleotide excision repair in xeroderma pigmentosum",1.096,1.118,1.109,1.099,1.091,101,103,102.1,92.1,101.3,100.5,101.4,101.2,101.8,100.3,105.5,103.5,101.5,103.7,102.6,96,92.5,79.7,98.9,101.7,104.9,101,100,103.8,22831.4,22783.7,22908.1,22573.9,23739.9,23289.4,22839.4,23332.1,23093.7,21607.6,20827.2,17930.4,22258.5,22892.4,23602.6,22720.7,22516,23366,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6UW78","Ubiquinol-cytochrome-c reductase complex assembly factor 3 [OS=Homo sapiens]",24,1,1,1,93,10.1,9.41,5.49,"cell organization and biogenesis;other metabolic processes","other membranes;cytosol;mitochondrion;nucleus","other molecular function","UQCC3","ENSG00000204922","","","Mitochondrial complex III assembly",1.097,1.138,0.935,0.989,0.931,108.1,112.1,92.1,98.5,97.5,91.7,106.4,89.2,109.1,110.4,111.9,107.8,90.8,92.6,86.3,97,94.3,140.3,78.4,96,107.7,102.3,90.3,89.2,46,38.5,47.1,47.7,48.4,46.6,39.2,40,37.3,41.9,40.8,60.6,33.9,41.5,46.6,44.2,39,38.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y6A5","Transforming acidic coiled-coil-containing protein 3 [OS=Homo sapiens]",32,22,51,22,838,90.3,5.05,162.76,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","","TACC3","ENSG00000013810","","Negative regulation of NOTCH4 signaling; NOTCH3 Activation and Transmission of Signal to the Nucleus","",1.098,0.943,0.952,0.98,1.018,110,94.4,95.3,100.2,98.2,101.9,107.2,106.5,107.2,91.5,92.1,95.4,96.5,93,92.9,95.5,97.7,135.9,103.9,95.8,93.4,99.4,103.7,92.4,4780.4,4746.7,4780.9,4081,4104.1,4252.1,4300.5,4143.9,4142.9,4256.7,4354.1,6058.6,4634,4269.1,4165.5,4431.7,4624.1,4120.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P55209","Nucleosome assembly protein 1-like 1 [OS=Homo sapiens]",55,16,318,6,391,45.3,4.46,1109.73,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","other molecular function","NAP1L1","ENSG00000187109","","","VEGFA-VEGFR2 signaling pathway; Overlap between signal transduction pathways contributing to LMNA laminopathies",1.098,1.056,1.092,1.112,1.1,102,98.1,101.4,92.9,103.3,102.2,102.1,104.7,103.4,101.6,94.6,99.4,101.4,102.8,102.9,94.2,103.7,61.4,106,104.5,104.8,105.4,103.5,103.6,23958.1,24553.1,24268.8,23824.5,22185.1,23328.5,23797.7,24127.5,24152.2,22096.1,24321.6,14411.6,24869,24511,24575.6,24737.5,24274,24302.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P06576","ATP synthase subunit beta, mitochondrial [OS=Homo sapiens]",74,28,876,28,529,56.5,5.4,3074.67,"other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;other cell component","signal transduction activity or receptor binding;transporter activity;other molecular function","ATP5F1B","ENSG00000110955","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein import; Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation",1.1,1.121,1.117,1.136,1.089,100.6,102.5,102.1,91.4,103.8,99.5,99.9,99.4,100.2,101.8,103.1,100.3,102.5,101.2,101.4,90.8,89.5,104.1,99.1,103.2,103.1,98.8,97.3,104.4,68867.2,68543.4,69040,70156,71039.3,69122.9,70634.1,69742.1,69885.8,62582.5,61666.4,71744.2,68305.2,71102.3,71078.6,68129.1,67076.8,71989.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P12955","xaa-Pro dipeptidase [OS=Homo sapiens]",34,16,71,16,493,54.5,6,226.04,"protein metabolism;other metabolic processes","","other molecular function","PEPD","ENSG00000124299","","","",1.1,1.115,1.07,1.058,1.065,103,104.4,100.2,93.6,99.1,99.7,103.5,101.6,103.7,104.8,103.7,107.2,97.3,100.6,104,94,86.2,94.5,98.3,99.5,103.8,100.1,96.8,100.5,8321.2,8175.5,8344.3,8428,8336.9,8624.3,7828.4,8089.3,8364,7561.6,6930.8,7597.5,7904.5,8003,8346.1,8050.3,7785.8,8081.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9P2X0-1","Dolichol-phosphate mannosyltransferase subunit 3 [OS=Homo sapiens]",24,2,11,2,92,10.1,5.94,36.9,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi;other cell component","enzyme regulator activity","DPM3","ENSG00000179085","N-Glycan biosynthesis; Metabolic pathways","Synthesis of dolichyl-phosphate mannose; Defective DPM1 causes DPM1-CDG (CDG-1e); Defective DPM3 causes DPM3-CDG (CDG-1o); Defective DPM2 causes DPM2-CDG (CDG-1u)","",1.102,1.094,0.942,1.088,1.003,106.2,105.4,90.7,96.3,104.8,96.6,92.6,107.3,118.7,85,112.6,106.5,91.6,83.4,100.9,82,97.3,98.1,109.3,105.9,97.2,128.2,97.6,85.5,1111.9,1288.1,1425.7,1020.9,1352.3,1278.7,1100.1,1001.1,1212,984.5,1168.3,1177.9,1312.2,1271.6,1166.9,1539.6,1172.4,1026.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q7L3T8","probable proline--tRNA ligase, mitochondrial [OS=Homo sapiens]",21,6,10,6,475,53.2,8.1,30.96,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion","other molecular function","PARS2","ENSG00000162396","Aminoacyl-tRNA biosynthesis","Mitochondrial tRNA aminoacylation","",1.103,1.042,1.069,1.084,1.03,104.6,98.8,101.3,94.8,102.8,97.7,106.6,95.7,101.7,96,99.2,94.4,98.5,98.8,95.2,92.2,90.5,148.6,99.9,100.6,98.7,95,88.7,99.7,655.1,587.8,624.7,590.1,609.4,580.2,605.1,606.8,585,566.2,556.2,913.2,613.9,618.1,606.5,583.4,544.7,612.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P54819","Adenylate kinase 2, mitochondrial [OS=Homo sapiens]",62,15,128,15,239,26.5,7.81,363.27,"other metabolic processes","cytoskeleton;mitochondrion;other cell component","kinase activity;other molecular function","AK2","ENSG00000004455","Purine metabolism; Thiamine metabolism; Metabolic pathways; Biosynthesis of cofactors","Interconversion of nucleotide di- and triphosphates","",1.104,1.065,1.022,1.021,1.065,105.6,101.8,97.7,95.6,97.6,101.8,103.3,106.3,105.4,102.5,98.4,101.6,97.5,92.7,103.2,89.9,108,95.4,100.8,97.4,96.1,101.6,101.6,98.2,14565.9,14988.2,14858.6,14453.5,13873,14326.8,13747.8,13071.9,14552.4,12683.2,15229.4,13456.9,14221.2,13737.3,13548.5,14332.5,14331.6,13850.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q969V3-2","Isoform 2 of Nicalin [OS=Homo sapiens]",38,18,52,18,562,62.8,6.89,199.34,"","","","NCLN","","","","",1.106,1.127,1.132,1.139,1.172,99.4,101.2,101.7,89.9,102.4,105.4,99,101.3,99.4,100.9,101.2,105.6,101.6,101.7,102.2,90.8,89.9,81.6,100.9,102.3,106.7,105.6,104.1,105.3,5152.3,5271.1,5175.1,5249.3,5268.9,5494.5,5285.7,5294.2,5319.8,4724.4,4677,4247.9,5252.6,5326.6,5552.5,5497.8,5416.6,5482.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6PI48","Aspartate--tRNA ligase, mitochondrial [OS=Homo sapiens]",23,14,46,14,645,73.5,8.02,132.15,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","DARS2","ENSG00000117593","Aminoacyl-tRNA biosynthesis","Mitochondrial tRNA aminoacylation","",1.107,1.113,1.124,1.126,1.152,100.3,100.8,101.9,90.6,102,104.4,100,100.6,101.9,101.3,101.2,100.8,102.8,101.8,102.2,91.5,90.9,84.2,101.6,102.4,103.6,105,103.3,104.8,6354.2,6394.1,6474,6437.8,6428.7,6406.8,6532.5,6470.2,6494.9,5811.3,5777.2,5346.2,6453,6505.1,6580.5,6671.4,6560.6,6657,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q12907","Vesicular integral-membrane protein VIP36 [OS=Homo sapiens]",42,13,93,13,356,40.2,6.95,303.48,"cell organization and biogenesis;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","LMAN2","ENSG00000169223","Protein processing in endoplasmic reticulum","COPII-mediated vesicle transport; Cargo concentration in the ER","",1.108,1.149,1.145,1.164,1.125,99.4,103,102.7,89.7,104.4,100.9,93.4,100.2,99.7,103.3,105.4,102.8,99.8,103.1,105.2,88.5,90,95,99.6,104.7,104.8,98.6,101.2,104.7,12738,13668,13606.5,14099.3,14379.8,14022.9,13612.2,14059.8,14358,12068.5,12275,12963.1,13591.8,14288.5,14304.3,13449.6,13809.3,14278,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y3E7","Charged multivesicular body protein 3 [OS=Homo sapiens]",9,2,2,2,222,25.1,5.12,5.28,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","CHMP3","ENSG00000115561","Endocytosis; Necroptosis","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","",1.11,1.072,1.044,1.017,1.015,106.4,102.8,100.1,95.9,97.5,97.3,91.6,105.7,113.5,101,102.1,110.5,90.7,99.5,103.5,81.6,95.2,119.7,96.8,103,94.3,94.8,99.8,96.6,81.9,94.5,101.5,90.3,91.3,98.8,81.1,88.9,92.6,73,85.2,107,86.6,92.1,84.3,84.7,89.3,86.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H3N1","Thioredoxin-related transmembrane protein 1 [OS=Homo sapiens]",32,8,25,8,280,31.8,4.98,80.11,"stress response","other membranes;ER/Golgi","other molecular function","TMX1","ENSG00000139921","","","",1.111,1.122,1.18,1.208,1.193,97.8,98.8,103.9,88,106.4,105.1,91.6,99.1,98.5,103.6,99.4,96.8,104.3,104.5,107.2,80,88.6,92,107.1,107.2,105.6,102.1,105.7,106.5,3408.4,3690.7,3665.6,3856.8,3701.8,3602.2,3884.2,3891.9,3989.9,2977.7,3298.9,3426.3,3986,3991,3932.8,3801.3,3935.9,3966.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q5QP82","DDB1- and CUL4-associated factor 10 [OS=Homo sapiens]",2,1,1,1,559,60.5,7.5,0,"protein metabolism;other metabolic processes","nucleus;other cell component","","DCAF10","ENSG00000122741","","Neddylation","",1.113,1.302,1.124,0.997,1.094,100.7,117.8,101.7,90.5,90.2,99,75.2,76.6,69.2,81.7,88,92,72,75.9,81.3,67.5,67,516.9,62.5,67.3,81.6,72.5,73.9,78.8,68.2,69.5,62.7,74.1,79.8,83.4,65.3,68.8,73.8,61.3,60.8,468.8,56.7,61.1,74,65.8,67,71.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O95352","Ubiquitin-like modifier-activating enzyme ATG7 [OS=Homo sapiens]",6,3,3,3,703,77.9,6.24,2.83,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;cytosol;cytoskeleton;other cell component","other molecular function","ATG7","ENSG00000197548","Autophagy; Autophagy; Ferroptosis; Neutrophil extracellular trap formation","Neutrophil degranulation; Antigen processing: Ubiquitination & Proteasome degradation; Signaling by BRAF and RAF1 fusions; Macroautophagy","Nanoparticle triggered autophagic cell death; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Senescence and autophagy in cancer",1.113,1.033,1.183,0.94,1.158,103.9,96.4,110.4,93.4,87.7,108.1,102.4,107.6,91.2,83.5,113.6,95.1,118.4,108.8,106.6,92,110,82.3,105.1,82.8,86.5,87.4,120,106.5,62.1,65.2,55.2,50.6,68.8,57.6,71.7,65.9,64.6,55.8,66.6,49.9,63.7,50.2,52.4,52.9,72.7,64.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P11021","78 kDa glucose-regulated protein [OS=Homo sapiens]",63,45,1056,42,654,72.3,5.16,3193.32,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component","translation activity;other molecular function","HSPA5","ENSG00000044574","Protein export; Protein processing in endoplasmic reticulum; Antigen processing and presentation; Thyroid hormone synthesis; Parkinson disease; Amyotrophic lateral sclerosis; Prion disease; Pathways of neurodegeneration; Lipid and atherosclerosis","Platelet degranulation ; PERK regulates gene expression; Regulation of HSF1-mediated heat shock response; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; IRE1alpha activates chaperones; ATF6 (ATF6-alpha) activates chaperone genes","Parkin-ubiquitin proteasomal system pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Photodynamic therapy-induced unfolded protein response; Prion disease pathway; Unfolded protein response; Orexin receptor pathway",1.115,1.071,1.131,1.15,1.113,101.7,97.7,103.2,91.2,104.8,101.5,102.4,102.1,101,103.5,96.2,98.1,103.9,103.6,103.3,91.5,97.7,78.5,105.5,105.2,102.6,103.3,99.7,101.9,127932.7,127536,126195.1,129339,120223.5,122572.3,129840.7,129421,129081.8,114394.8,122139.3,98069.4,131845.7,131518.3,128224.8,129089.7,124640.1,127275.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P04920-1","Anion exchange protein 2 [OS=Homo sapiens]",26,23,59,23,1241,136.9,6.29,248.64,"transport;developmental processes;other biological processes","plasma membrane;other membranes","transporter activity;other molecular function","SLC4A2","ENSG00000164889","Salivary secretion; Gastric acid secretion; Pancreatic secretion; Bile secretion","Bicarbonate transporters","Proximal tubule transport",1.115,1.123,1.117,1.117,1.066,102.4,103,102.5,91.8,102.5,97.8,98.5,102.8,102.2,106.1,102.9,102.4,104.4,101.6,102.3,89.8,91.6,100.9,103,96.1,102.3,97.7,97.1,98.3,3978.7,4150.9,4126.1,4283.3,4154,4134.1,4216.6,4101.4,4131.8,3627.6,3698.9,4072.9,4157.9,3878.3,4132.6,3943.8,3920.8,3969.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UQ49","Sialidase-3 [OS=Homo sapiens]",11,5,5,5,428,48.2,7.17,5.85,"other metabolic processes;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","NEU3","ENSG00000162139","Other glycan degradation; Sphingolipid metabolism; Metabolic pathways","Sialic acid metabolism; Glycosphingolipid metabolism","",1.117,1.158,1.095,1.081,1.095,102.4,106.1,100.4,91.7,99.1,100.3,101.3,99.1,109.6,108.6,105,100.9,90.6,99.3,100.1,90.7,78.4,129.9,98,91.8,100.7,96,99.3,100.6,321.8,314.9,348.3,345,333.5,320.5,287.8,315.3,317.8,288,249.2,412.6,311.4,291.8,320,305,315.3,319.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O15228","Dihydroxyacetone phosphate acyltransferase [OS=Homo sapiens]",23,14,32,14,680,77.1,6.57,82.48,"cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;other cytoplasmic organelle","other molecular function","GNPAT","ENSG00000116906","Glycerophospholipid metabolism; Peroxisome","Peroxisomal protein import; Plasmalogen biosynthesis; Synthesis of PA","Triacylglyceride synthesis",1.118,1.231,1.175,1.137,1.185,98,107.9,103,87.7,99.7,103.8,100,96.7,96.6,99.2,114.8,106.6,102.4,101.7,101,102,86.1,86.6,97,98.5,102,102.6,102,104.4,3411.2,3299.4,3293.2,3382.6,3913.5,3634.2,3492.6,3467.6,3443.9,3477.7,2936.5,2952.2,3309.6,3358,3478.9,3497.4,3476.8,3560.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H6P5","Threonine aspartase 1 [OS=Homo sapiens]",12,3,3,3,420,44.4,7.75,6.42,"protein metabolism;other metabolic processes;other biological processes","other cell component","other molecular function","TASP1","ENSG00000089123","","","",1.12,1.178,1.183,1.156,1.102,99.7,104.9,105.3,89,102.9,98.1,98.6,101.5,92.3,105.9,103.8,98.2,103.3,110.8,104.2,88.1,87.5,109.5,89.7,101.8,102.6,96.9,97,108.1,159.6,164.4,149.5,171.5,168,159.1,167.2,179.4,168.7,142.6,141.7,177.4,145.2,164.9,166.1,156.8,157.1,175,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q04844","Acetylcholine receptor subunit epsilon [OS=Homo sapiens]",1,1,1,1,493,54.7,5.26,2.27,"cell-cell signaling;transport;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","transporter activity;other molecular function","CHRNE","ENSG00000108556","Neuroactive ligand-receptor interaction","Highly sodium permeable postsynaptic acetylcholine nicotinic receptors","",1.121,1.249,1.162,1.137,1.226,97.6,108.7,101.1,87,98.9,106.7,97.4,100.5,104.9,107.8,116.1,111.9,104.1,120.5,104.2,102,89.6,15.5,104.7,101.9,91.2,106.7,111,109.9,134.9,139.1,145.1,149.2,160.6,154.9,144.2,166.8,144.2,141.2,124.1,21.4,145,141,126.3,147.7,153.7,152.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O95299","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [OS=Homo sapiens]",35,10,24,10,355,40.7,8.48,57.68,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;other cell component","transporter activity","NDUFA10","ENSG00000130414","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",1.121,1.114,1.127,1.098,1.155,101.7,101,102.2,90.7,99.6,104.7,105.2,100.2,102.2,100.2,105.5,101.5,104,96.6,102.7,98,91.1,77.8,100.9,99.1,100.1,105.9,103.6,105.2,2481.9,2365.3,2412,2365.8,2490.3,2395.7,2454.1,2280.1,2423.6,2313.7,2151,1836.9,2380.5,2337.9,2361.1,2499.6,2444.6,2483.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q86X10-1","Ral GTPase-activating protein subunit beta [OS=Homo sapiens]",7,8,16,8,1494,166.7,6.79,46.82,"other biological processes","","enzyme regulator activity;other molecular function","RALGAPB","ENSG00000170471","","Translocation of SLC2A4 (GLUT4) to the plasma membrane","",1.123,1.093,1.066,1.086,1.031,105.3,102.5,100,93.8,101.8,96.6,104.3,106,105.7,106.9,95.3,102.9,96.5,101.7,100.3,90.7,103.3,94.1,102.4,102.2,98.6,97,98,94.1,632.7,642.5,640.7,648,578.2,623.8,585.3,616.5,608.5,550,626.5,570.8,620.7,619.8,597.8,588.2,594.1,570.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8IXI1","Mitochondrial Rho GTPase 2 [OS=Homo sapiens]",28,12,42,11,618,68.1,5.86,152.07,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;mitochondrion","other molecular function","RHOT2","ENSG00000140983","Mitophagy","RHOT2 GTPase cycle","",1.123,1.135,1.133,1.146,1.139,101,102,101.8,89.9,103,102.4,98.3,98.1,100.4,99.3,106,98.7,100.3,99.2,99.1,87.5,83,128.5,100.1,100.3,101.2,98.2,99.7,102.1,2929.1,2921.8,2991.6,2959.3,3157.9,2941.1,2988.7,2954.6,2952.7,2607.8,2472.3,3829.1,2981.4,2987.5,3015.3,2924.9,2970.4,3041,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UBN7-1","histone deacetylase 6 [OS=Homo sapiens]",12,11,22,11,1215,131.3,5.3,57.85,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","HDAC6","ENSG00000094631","Neutrophil extracellular trap formation; Amyotrophic lateral sclerosis; Alcoholism; Viral carcinogenesis","Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Cilium Assembly; Aggrephagy; Notch-HLH transcription pathway; Late endosomal microautophagy; Transcriptional regulation by RUNX2; RUNX2 regulates osteoblast differentiation; Chaperone Mediated Autophagy; HSF1 activation","Neural crest differentiation; Ectoderm differentiation; Ectoderm differentiation; Ethanol effects on histone modifications; 7q11.23 copy number variation syndrome",1.125,1.156,1.137,1.156,1.158,100.3,103,101.3,89.1,103,103.2,99.8,101.7,102.3,99.7,105.6,104.4,101.8,103.5,102.7,94.8,90.3,68.3,102.8,104.4,106.6,104.6,104.7,101.9,2189.5,2229.2,2243.1,2186.2,2314.9,2289.1,2231.3,2269.4,2251.3,2079.3,1980.7,1497.4,2254.8,2290.2,2337.9,2294.2,2296.8,2235.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q7Z5G4-1","Golgin subfamily A member 7 [OS=Homo sapiens]",27,4,8,4,137,15.8,7.05,22.93,"protein metabolism;other metabolic processes;transport;other biological processes","non-structural extracellular;other membranes;ER/Golgi;other cell component","","GINS4; Golga7; GOLGA7; LOC111144588","ENSAMEG00000002741; ENSBIXG00000010291; ENSBIXG00005008055; ENSBTAG00000027626; ENSCANG00000042534; ENSCATG00000030664; ENSCCAG00000022569; ENSCHIG00000000610; ENSCJAG00000011057; ENSCSAG00000015096; ENSECAG00000020655; ENSFCAG00000018740; ENSG00000147533; ENSGGOG00000001532; ENSHGLG00000002906; ENSLCNG00005002825; ENSMFAG00000032651; ENSMLEG00000030214; ENSMMUG00000016120; ENSMNEG00000034042; ENSMPUG00000005819; ENSNLEG00000012577; ENSPANG00000016690; ENSPCTG00005011352; ENSPPAG00000034789; ENSPPYG00000018542; ENSPTRG00000020193; ENSRBIG00000039536; ENSRFEG00010000282; ENSRROG00000028796; ENSSSUG00005000335; ENSSTOG00000004024; ENSUMAG00000025576; ENSVVUG00000020415","","Neutrophil degranulation; Neutrophil degranulation; RAS processing; RAS processing","",1.127,1.166,1.135,1.126,1.08,101.9,105.4,102.7,90.5,101.8,97.7,94.4,102.1,101.5,105.9,105,103.5,100.9,103.7,102.2,89.7,95.9,90.1,101.4,108.1,98.4,97.3,94.6,105.3,1012.7,1096,1089.3,1136.9,1126.8,1110.7,1083.2,1112.4,1097.1,962.2,1029.2,966.7,1088.2,1159.8,1055.8,1043.8,1014.9,1129.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q12905","Interleukin enhancer-binding factor 2 [OS=Homo sapiens]",72,18,245,18,390,43,5.26,788.07,"other biological processes","nucleus;other cell component","nucleic acid binding activity","ILF2","ENSG00000143621","","Neutrophil degranulation","B cell receptor signaling pathway",1.129,1.13,1.137,1.127,1.132,101.8,101.9,102.5,90.2,101.6,102,102.5,102.1,102.5,102.5,107.5,102.6,98.4,103.3,104.1,95.3,90.8,70.1,99.9,102.4,104.8,102.8,102.6,105.6,19219.3,19147.1,19222.4,19212,20151.8,19244.8,18448.8,19368.8,19520.6,17874.1,17030.2,13150.3,18736.1,19194.1,19649.8,19274.1,19243.7,19792.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P19823","Inter-alpha-trypsin inhibitor heavy chain H2 [OS=Homo sapiens]",4,4,7,4,946,106.4,6.86,18.18,"other metabolic processes;other biological processes","non-structural extracellular;ER/Golgi","enzyme regulator activity","ITIH2","ENSG00000151655","","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",1.13,1.289,1.122,1.217,1.183,97.7,111.5,97,86.4,105.2,102.3,95.3,97.5,101.6,103.6,111.2,112.3,94.3,96.8,105.9,85.3,86.3,96.3,94.6,105,113.4,96.5,102.1,102.1,1009.3,1032.7,1076,1097.6,1178.6,1189.3,998.5,1025.7,1121.6,904,914.2,1020.6,1001.7,1112.3,1201.4,1022.8,1081.7,1082,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P41247-1","Patatin-like phospholipase domain-containing protein 4 [OS=Homo sapiens]",6,1,1,1,253,28,9.11,4.36,"other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;other cell component","other molecular function","PNPLA4","ENSG00000006757","Retinol metabolism; Metabolic pathways","Triglyceride catabolism","",1.131,1.202,1.181,1.113,1.241,98.8,105.1,103.2,87.4,97.2,108.4,97.1,120.3,90.5,92,103.3,118,101.4,82.6,116.6,80.5,85.9,117.3,90.6,102.7,95.5,109.2,90,106.6,34.7,42.9,32.3,32.8,36.9,42.1,36.2,29.5,41.6,28.8,30.7,41.9,32.4,36.7,34.1,39,32.1,38,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O75044","SLIT-ROBO Rho GTPase-activating protein 2 [OS=Homo sapiens]",31,28,60,28,1071,120.8,6.7,171.11,"","","","","","","","",1.133,1.119,1.113,1.093,1.084,103.9,102.7,102.1,91.7,100.3,99.4,107.9,103.9,103.6,100.4,102.9,102.6,98.3,102.1,103.3,95,91.7,88.6,99.8,100.2,101.6,99.5,99.4,99.1,7912.6,7613.3,7591.7,7359.1,7541,7523.9,7206.1,7482.1,7575.2,6965.9,6721.1,6491.6,7317.1,7348,7450.2,7296.7,7284.9,7263,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q10567","AP-1 complex subunit beta-1 [OS=Homo sapiens]",41,34,156,17,949,104.6,5.06,450.54,"transport;developmental processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","AP1B1","ENSG00000100280","Lysosome; Human immunodeficiency virus 1 infection","MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression","",1.134,1.153,1.161,1.094,1.137,101.9,103.6,104.3,89.8,98.2,102.2,102.3,101.9,102.5,102.8,104,106.8,99.4,104.7,106.1,95.1,90.2,77.8,97.4,98.6,103.8,101.2,102.5,102.9,17303.8,17237.5,17338.2,17389.5,17592.9,18071.4,16811.8,17713.2,17952.7,16081.5,15252.9,13159.8,16476.2,16681,17557.4,17124.6,17347,17409,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8N2F6-1","Armadillo repeat-containing protein 10 [OS=Homo sapiens]",8,2,4,2,343,37.5,6.61,7.48,"other biological processes","other membranes;mitochondrion;ER/Golgi","other molecular function","ARMC10","ENSG00000170632","","","",1.135,1.159,1.081,1.058,1.169,103.2,105.3,98.3,90.9,96.2,106.2,96.7,98,103.1,108.3,100.1,92.2,87.6,95.4,93.4,82.1,86.3,188.9,91.4,82.9,93.8,100.9,103,95.9,219.6,222.4,234.1,245.8,227.1,209.3,198.9,216.5,211.9,186.3,195.9,428.6,207.4,188.1,212.8,229,233.8,217.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P52179-1","Myomesin-1 [OS=Homo sapiens]",1,1,5,1,1685,187.5,6.93,6.94,"developmental processes;signal transduction;other biological processes","cytoskeleton","cytoskeletal activity;other molecular function","MYOM1","ENSG00000101605","","","Striated muscle contraction pathway",1.136,1.265,1.234,1.157,1.288,96.3,107.2,104.6,84.7,98.1,109.1,94.6,99,100.2,109,110.2,111.4,105.5,112,107.5,94.9,87.1,56.4,101.7,92.4,100.8,112.2,90.3,114.6,440.2,460.9,466.3,507.4,513.1,518.5,491.3,521.4,500.6,441.9,405.6,262.4,473.4,430.1,469.3,522.3,420.5,533.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8N8Q9","Magnesium transporter NIPA2 [OS=Homo sapiens]",4,1,1,1,360,39.2,8.22,5.24,"transport","plasma membrane;other membranes;other cytoplasmic organelle","transporter activity","NIPA2","ENSG00000140157","","Miscellaneous transport and binding events","Prader-Willi and Angelman syndrome; 15q11.2 copy number variation syndrome",1.139,1.049,1.185,1.042,1.158,103.9,95.8,108.2,91.3,95.1,105.7,109.3,107.6,109.6,102,100.8,88.9,96.4,117.6,113.8,96,98.3,21.3,108.8,100.1,96.8,111.2,103.7,117.8,212.3,208.9,212.7,198.1,195.6,172.6,187.2,228.4,220.9,186.5,190.9,41.4,211.3,194.3,188,215.8,201.4,228.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H0U9","Testis-specific Y-encoded-like protein 1 [OS=Homo sapiens]",20,5,9,5,437,49.2,5.45,30.11,"cell organization and biogenesis","nucleus;other cell component","other molecular function","TSPYL1","ENSG00000189241","","","Sudden infant death syndrome (SIDS) susceptibility pathways",1.141,1.269,1.221,1.106,1.015,101.4,112.8,108.5,88.9,98.3,90.2,97.9,99.3,107,111,104.9,110.5,93.6,107.2,106.3,78.6,87,143.3,96.3,89.6,98.9,86.5,93.8,88.3,539.8,547.1,589.8,612,578.2,608.9,515.8,591.1,585.7,433.3,479.7,789.6,530.8,494.1,545.3,476.6,516.8,486.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8N0Z8","tRNA pseudouridine synthase-like 1 [OS=Homo sapiens]",10,3,5,3,303,33.2,9.85,13.95,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","PUSL1","ENSG00000169972","","","",1.141,1.143,1.097,1.095,1.104,104,104.2,100,91.2,99.9,100.7,97.9,101,101,101.1,110.1,99.9,97,104.6,92.9,88.5,82.6,138.1,91.8,107.8,96.9,97.7,87.7,103.5,324.5,334.9,334.7,335.1,365.1,331.2,321.7,346.9,308.1,293.3,273.7,457.8,304.2,357.2,321.2,323.9,290.6,343.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P27816-5","Isoform 5 of Microtubule-associated protein 4 [OS=Homo sapiens]",46,32,151,2,809,85.2,7.71,350.39,"","","","MAP4","","","","",1.146,1.204,1.145,1.07,1.103,103.1,108.4,103,90,96.3,99.2,103.4,99,109.9,102.2,108.7,117.8,97.4,107,103.3,90.2,93.7,71.7,96.5,94.8,102.6,95,107.2,99.5,374.4,358.7,398,370.1,393.6,426.7,352.9,387.6,374,326.8,339.3,259.9,349.7,343.4,371.7,344.2,388.5,360.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P25963","NF-kappa-B inhibitor alpha [OS=Homo sapiens]",11,3,3,3,317,35.6,4.68,6.47,"stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","NFKBIA","ENSG00000100906","cAMP signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; Apoptosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; TNF signaling pathway; Neurotrophin signaling pathway; Adipocytokine signaling pathway; Relaxin signaling pathway; Insulin resistance; Alcoholic liver disease; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Legionellosis; Yersinia infection; Leishmaniasis; Chagas disease; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Chemical carcinogenesis; Prostate cancer; Chronic myeloid leukemia; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; RIP-mediated NFkB activation via ZBP1; NF-kB is activated and signals survival; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; SUMOylation of immune response proteins","Nucleotide-binding oligomerization domain (NOD) pathway; Regulation of toll-like receptor signaling pathway; IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; RAC1/PAK1/p38/MMP2 pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; IL-4 signaling pathway; NO/cGMP/PKG mediated neuroprotection; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - interferon induction; Neuroinflammation; STING pathway in Kawasaki-like disease and COVID-19; Burn wound healing; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; T-cell receptor (TCR) signaling pathway; Toll-like receptor signaling pathway",1.146,1.156,1.149,1.187,1.1,102.1,103,102.3,89.1,105.7,97.9,97.2,88.1,93.1,93.9,84.9,94.4,93.3,96.6,90.1,79.3,81.2,240.9,92.6,103.5,96.4,89.3,96.2,89.2,376.3,341.1,360.3,363.5,328.5,365.3,361.2,373.9,348.7,307,314.4,932.4,358.6,400.8,373.1,345.8,372.3,345.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P47897","glutamine--tRNA ligase [OS=Homo sapiens]",51,38,217,37,775,87.7,7.15,647.77,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;mitochondrion;other cell component","enzyme regulator activity;other molecular function","QARS1","ENSG00000172053","Aminoacyl-tRNA biosynthesis; Metabolic pathways","Selenoamino acid metabolism; Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation","",1.149,1.128,1.149,1.161,1.155,102.2,100.4,102.2,89,103.3,102.8,104,101.2,102.8,100.6,100.9,105,101.7,103.3,102.8,92.7,89.4,77,100.6,104.8,103.9,103.3,103.4,102.8,26025.4,25326.5,25723.1,25190,25262.4,26291.5,25448.4,25867.5,25724.7,23203,22390.7,19274.8,25172.1,26230.3,26000.7,25850.6,25879.4,25721.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P20337","Ras-related protein Rab-3B [OS=Homo sapiens]",28,6,22,4,219,24.7,5.02,58.31,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB3B","ENSG00000169213","","RAB geranylgeranylation","Intracellular trafficking proteins involved in CMT neuropathy",1.15,1.176,1.128,1.209,1.125,101.7,103.9,99.7,88.4,106.9,99.4,99.1,102.4,102.1,104.4,101.7,105,102.2,98,100.2,88.8,96.3,78.2,101.2,107.4,110.1,98.7,99.9,104.5,1893.9,1956,1951.5,1994.3,1943.9,2005.9,1951.9,1872.9,1913.8,1696.5,1840.1,1493.7,1932.8,2051.7,2104.2,1885.1,1908,1996.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P49189","4-trimethylaminobutyraldehyde dehydrogenase [OS=Homo sapiens]",49,21,128,21,494,53.8,5.87,332.97,"cell organization and biogenesis;other metabolic processes","cytosol;other cell component","other molecular function","ALDH9A1","ENSG00000143149","Glycolysis / Gluconeogenesis; Ascorbate and aldarate metabolism; Fatty acid degradation; Valine, leucine and isoleucine degradation; Lysine degradation; Arginine and proline metabolism; Histidine metabolism; Tryptophan metabolism; beta-Alanine metabolism; Glycerolipid metabolism; Pyruvate metabolism; Metabolic pathways; Alcoholic liver disease","Carnitine synthesis","GABA receptor signaling; Tryptophan metabolism; Fluoroacetic acid toxicity",1.151,1.2,1.163,1.157,1.17,101,105.3,102,87.7,101.5,102.6,101.5,101.4,101.9,105.8,105.8,108.9,101.6,102.6,105,92.9,88.2,68.4,100.5,102,104.3,104.6,103.1,101.6,18241.6,18225.3,18316,19005.5,19014.6,19567.4,18260.4,18429.2,18860.2,16692.3,15842.3,12291.7,18054.9,18331.5,18751.2,18790,18535.8,18256.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8N9N2-2","Isoform 2 of Activating signal cointegrator 1 complex subunit 1 [OS=Homo sapiens]",22,5,8,5,357,41.2,5.53,19.26,"","","","ASCC1","","","","",1.156,1.141,1.223,1.117,1.181,101.8,100.4,107.6,88,98.3,103.9,101.9,104.6,104.2,102.8,110.1,100.5,98.3,110.2,111.7,103.8,90.1,42.4,100.6,98.1,100.9,106.4,106,107.2,1251.2,1284.8,1279.4,1262.6,1352.7,1234.7,1207.2,1352.8,1372.3,1275.2,1106.4,520.9,1236,1205,1239.3,1306.6,1302.1,1316.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P50053-2","Isoform A of Ketohexokinase [OS=Homo sapiens]",34,8,14,8,298,32.7,5.94,46.52,"","","","KHK","","","","",1.157,1.225,1.167,1.158,1.179,100.8,106.8,101.7,87.1,100.9,102.7,103,101.3,101.4,100.8,107.4,107.9,95.6,102.7,102.2,101.3,87.6,74.5,101.5,98.5,106.3,103.3,103.3,101.4,1727.1,1699.5,1700.4,1690.8,1800.4,1810.1,1602.6,1722.1,1714.6,1698.3,1469.3,1248.9,1701.6,1652.5,1783.2,1732.3,1732.7,1701.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P62820","Ras-related protein Rab-1A [OS=Homo sapiens]",81,16,128,7,205,22.7,6.21,380.98,"cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","RAB1A","ENSG00000138069","Autophagy; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Pathogenic Escherichia coli infection; Legionellosis","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Golgi Cisternae Pericentriolar Stack Reorganization","",1.159,1.266,1.251,1.242,1.242,97.1,106.1,104.8,83.8,104,104.1,93.2,98.9,100,104.6,108,113.9,100.4,106.7,107.3,85.3,87.7,63.7,98.8,105.9,106.8,103.2,109.4,106,19031.8,20189.4,20414.9,21355.9,22052,23251.9,20498.1,21788.1,21903.7,17414.1,17901.8,12999.1,20176.7,21620.4,21811,21066.1,22324.2,21635.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NPJ3-1","Acyl-coenzyme A thioesterase 13 [OS=Homo sapiens]",29,3,11,3,140,15,9.14,33.76,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus","other molecular function","ACOT13","ENSG00000112304","","Mitochondrial Fatty Acid Beta-Oxidation","",1.161,1.159,1.136,1.134,1.178,102.9,102.7,100.7,88.6,100.6,104.5,101.1,106.4,103.9,102.6,103.7,106.4,96.9,101.6,109.2,96.4,89.5,63.1,102.1,101.5,98.9,108.5,105.5,102.6,1910.7,2010.6,1963.7,1939.8,1960.2,2010.7,1831.7,1921.1,2063.3,1822.9,1691.5,1192.7,1930.3,1918.8,1870.2,2051.6,1993.5,1938.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NRK6","ATP-binding cassette sub-family B member 10, mitochondrial [OS=Homo sapiens]",20,12,24,11,738,79.1,9.85,65.19,"other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","ABCB10","ENSG00000135776","ABC transporters","Mitochondrial ABC transporters","",1.164,1.137,1.2,1.197,1.186,101.4,99.1,104.6,87.2,104.4,103.4,101.3,103.4,99.3,106.5,97.2,98.9,97.8,104.4,107,87,95.9,73.6,102.3,105,104.2,103.2,102.6,110.2,2534.5,2588.4,2485.2,2664.2,2432.8,2475.5,2447.1,2613.3,2676.2,2177.7,2399.2,1842.7,2559.6,2627.6,2607.6,2582.4,2566.6,2756.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q99623","Prohibitin-2 [OS=Homo sapiens]",71,21,181,21,299,33.3,9.83,509.8,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;nucleus;other cell component","other molecular function","PHB2","ENSG00000215021","","Processing of SMDT1","",1.166,1.186,1.163,1.166,1.212,101.4,103.2,101.3,87,101.5,105.5,102.7,100.6,101.1,98.6,104.3,102.9,99.1,100.9,104.3,92.4,86.7,84.9,100.2,101.1,105.2,104.4,105.1,105.5,24628.6,24108.2,24227.8,23632.1,24990.8,24656.4,23757.7,24181.4,24995.7,22141.3,20784,20350.5,24030.2,24243.8,25224.8,25028.3,25200.2,25286.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P42766","60S ribosomal protein L35 [OS=Homo sapiens]",28,4,12,4,123,14.5,11.05,22.64,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;translational apparatus;nucleus","nucleic acid binding activity;other molecular function","RPL35","ENSG00000136942","Ribosome; Coronavirus disease","Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",1.167,1.022,1.022,0.968,1.161,110.5,96.7,96.7,94.6,91.6,109.9,94.4,121.4,111.8,97.9,92.7,100.2,97.9,98.7,91.9,95.8,104.8,79.7,112.3,92.8,90,111.2,112.4,94.2,2382.8,3062,2821.6,2469.5,2338.9,2529.1,2469.5,2491.2,2318.2,2417.4,2643.8,2010.2,2833.7,2340.7,2270.3,2806.5,2836.9,2376.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y619","mitochondrial ornithine transporter 1 [OS=Homo sapiens]",5,2,2,2,301,32.7,9.13,2.12,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","SLC25A15","ENSG00000102743","","Urea cycle","",1.17,1.203,1.098,1.077,1.202,104,107,97.6,88.9,95.7,106.8,91.5,77.6,96.8,82.2,94.1,102.2,85.9,105.4,83,77.1,78.2,281.2,86.3,84.2,81,94,91.2,108.1,65.2,55.3,69,58.6,67.1,72.8,61.2,75.2,59.2,55,55.8,200.5,61.5,60,57.7,67,65,77.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q92947-1","Glutaryl-CoA dehydrogenase, mitochondrial [OS=Homo sapiens]",47,14,50,13,438,48.1,8.06,172.48,"other metabolic processes","mitochondrion","other molecular function","GCDH","ENSG00000105607","Fatty acid degradation; Lysine degradation; Tryptophan metabolism; Metabolic pathways","Lysine catabolism","Fatty acid beta-oxidation; Tryptophan metabolism",1.172,1.165,1.162,1.197,1.128,103.1,102.4,102.1,87.9,105.3,99.2,102.7,100.5,104.8,104.1,96.1,102,101.3,101.7,103.6,86.3,87.6,103.1,99.1,104.9,105.3,97.3,98.8,100.8,3568.3,3492,3643.1,3618.5,3339,3545,3518.5,3535.5,3598.9,3000.3,3043.7,3582.4,3443.8,3644,3659,3380.7,3433,3503.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P28070","Proteasome subunit beta type-4 [OS=Homo sapiens]",48,8,68,8,264,29.2,5.97,226.68,"protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","other molecular function","PSMB4","ENSG00000159377","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration","Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Regulation of RUNX2 expression and activity; UCH proteinases; ROS sensing by NFE2L2; Regulation of PTEN stability and activity; Regulation of RAS by GAPs; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease",1.175,1.208,1.164,1.097,1.166,103.5,106.4,102.6,88.1,96.6,102.7,100.8,102.9,103.4,100.5,105.8,110.2,96.9,102,104.6,96.5,87.6,82.8,95.6,96.1,107.1,102.1,100.4,104.6,4709.9,4810.7,4831.4,4699.4,4946.3,5151.5,4527.6,4766.1,4890.9,4511.4,4093.6,3871.4,4469,4490.1,5005.3,4772.9,4691.8,4888.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P05026","Sodium/potassium-transporting ATPase subunit beta-1 [OS=Homo sapiens]",8,3,5,3,303,35,8.53,5.59,"cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","transporter activity;other molecular function","ATP1B1","ENSG00000143153","cGMP-PKG signaling pathway; cAMP signaling pathway; Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Insulin secretion; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Aldosterone synthesis and secretion; Aldosterone-regulated sodium reabsorption; Endocrine and other factor-regulated calcium reabsorption; Proximal tubule bicarbonate reclamation; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Carbohydrate digestion and absorption; Protein digestion and absorption; Bile secretion; Mineral absorption","Ion homeostasis; Ion transport by P-type ATPases; Potential therapeutics for SARS; Basigin interactions","Proximal tubule transport; Calcium regulation in cardiac cells",1.179,1.178,1.1,1.206,1.119,104.3,104.2,97.3,88.5,106.7,99,102.4,108.8,102,103,100.3,102.4,95,95.6,102.2,85.8,86.9,106.4,104.8,111.2,102.2,97.2,94.9,98.9,602.9,640.6,600.2,606,590.1,602.7,558.9,562.7,601.4,505,511.5,626.3,616.8,654.4,601.2,572.1,558.8,581.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P36957","Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [OS=Homo sapiens]",41,16,101,16,453,48.7,8.95,299.27,"protein metabolism;other metabolic processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","other molecular function","DLST","ENSG00000119689","Citrate cycle (TCA cycle); Lysine degradation; Tryptophan metabolism; Metabolic pathways; Carbon metabolism","Citric acid cycle (TCA cycle); Glyoxylate metabolism and glycine degradation; Lysine catabolism","TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Metabolic reprogramming in colon cancer; 7q11.23 copy number variation syndrome; TCA cycle (aka Krebs or citric acid cycle)",1.181,1.172,1.188,1.164,1.169,103.1,102.3,103.7,87.3,101.6,102,107.8,104.2,103.6,105.2,100.2,103.4,100.8,104.8,106.6,88.2,90.5,68.5,100.7,104.9,102.7,103.1,101.6,103.3,11124.1,10747.4,10690.9,10853.4,10337.5,10667.6,10395,10809.5,10996.4,9101.1,9339.8,7068.2,10384.6,10817.7,10593.4,10639.5,10476.8,10655.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8IYA6","Cytoskeleton-associated protein 2-like [OS=Homo sapiens]",12,7,10,7,745,83.5,9.83,24.32,"","cytosol;cytoskeleton","","CKAP2L","ENSG00000169607","","","",1.183,0.975,1.088,1.149,1.161,108.3,89.3,99.6,91.5,105.1,106.2,104.9,108.5,109.3,92.6,89.3,89.5,99.7,103.6,99.8,88,92,91.7,107.1,103.9,105.3,108,106.4,100.5,763.3,790,795.5,674.2,649.9,651.2,726.1,753.9,726.5,640.4,669.7,667.6,779.7,756.4,766.8,786,774.9,731.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P15121","aldose reductase [OS=Homo sapiens]",72,18,128,16,316,35.8,6.98,425.69,"other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","AKR1B1","ENSG00000085662","Pentose and glucuronate interconversions; Fructose and mannose metabolism; Galactose metabolism; Glycerolipid metabolism; Folate biosynthesis; Metabolic pathways","Pregnenolone biosynthesis; Fructose biosynthesis","Eicosanoid metabolism via cyclooxygenases (COX); Polyol pathway; Metapathway biotransformation Phase I and II",1.184,1.277,1.173,1.216,1.277,99.7,107.5,98.7,84.2,102.4,107.5,103,100.2,100.1,95.2,108.1,111.4,99.3,101.6,99.1,97.8,84.7,69.7,98.2,102.9,104.7,108.1,113.3,102.5,18285.4,17790.3,17765.6,16899.9,19190.9,19767.3,17625.8,18028.2,17588.5,17357.7,15029.1,12368.3,17433.9,18269.8,18587.7,19191.8,20101.2,18187.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y2Q5","Ragulator complex protein LAMTOR2 [OS=Homo sapiens]",54,3,8,3,125,13.5,5.4,24.11,"other biological processes","plasma membrane;other membranes;other cytoplasmic organelle","enzyme regulator activity;other molecular function","LAMTOR2","ENSG00000116586","mTOR signaling pathway","Neutrophil degranulation; TP53 Regulates Metabolic Genes; MAP2K and MAPK activation; Regulation of PTEN gene transcription; Amino acids regulate mTORC1; Macroautophagy; mTORC1-mediated signalling; Energy dependent regulation of mTOR by LKB1-AMPK","",1.189,0.947,0.93,0.964,1.078,116.8,93,91.3,98.2,94.7,105.9,138,113.1,122.2,97.3,63.4,120.8,83.3,95.5,106.7,102.8,128.1,12.1,90.5,115.2,99.1,110.8,113.9,87.2,484.6,397.2,429.4,341.9,222.7,424.3,292.8,335.6,374.8,361,449.8,42.3,318,404.5,348.2,389.1,400,306.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q5H8A4-1","GPI ethanolamine phosphate transferase 2 [OS=Homo sapiens]",2,2,4,2,983,108.1,7.15,13.4,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","PIGG","ENSG00000174227","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways","Synthesis of glycosylphosphatidylinositol (GPI)","",1.191,1.32,1.26,1.177,1.222,99.7,110.5,105.4,83.7,98.5,102.2,96.6,98.5,101.3,111.2,102.7,109.1,101.7,106.3,104.2,82.7,81.4,97,97.3,91.7,108.8,96.8,101,111.9,212,216.1,222.2,243.9,225.3,239.5,223.2,233.2,228.6,181.4,178.6,212.8,213.6,201.1,238.7,212.3,221.6,245.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P16435","NADPH--cytochrome P450 reductase [OS=Homo sapiens]",56,31,103,31,677,76.6,5.58,308.67,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cell component","other molecular function","POR","ENSG00000127948","","Cytochrome P450 - arranged by substrate type","Oxidation by cytochrome P450",1.195,1.2,1.215,1.201,1.195,102.3,102.8,104,85.6,102.9,102.3,96.1,103.3,103.1,103.5,106,103.6,103.9,104.8,105.7,86.3,86.8,76.3,102,103.7,105.7,100.9,103.1,105.1,10761.4,11564.6,11546.6,11596.5,11869.8,11601.3,11634.8,11741.4,11838.3,9664,9723,8547.2,11425.2,11609.3,11842.5,11304.2,11550.3,11767.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9ULC4-1","Malignant T-cell-amplified sequence 1 [OS=Homo sapiens]",48,7,14,7,181,20.5,8.82,52.18,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;translational apparatus;other cell component","nucleic acid binding activity","LOC101344388; LOC112809463; Mcts1; MCTS1; MCTS2","ENSAMEG00000029271; ENSANAG00000033714; ENSBIXG00005000064; ENSBTAG00000034992; ENSCAFG00000018545; ENSCANG00000043353; ENSCATG00000045065; ENSCCAG00000024478; ENSCHIG00000016396; ENSCJAG00000002593; ENSCSAG00000018337; ENSG00000232119; ENSG00000288295; ENSGGOG00000009420; ENSMLEG00000040575; ENSMMUG00000009043; ENSMNEG00000041580; ENSNLEG00000015021; ENSPANG00000011471; ENSPCOG00000020584; ENSPPAG00000040584; ENSPTRG00000022241; ENSRROG00000039816; ENSSBOG00000031550; ENSSTOG00000011496","","","",1.199,1.233,1.159,1.155,1.226,103.1,106.1,99.8,86.1,99.4,105.5,105.2,103.7,106.1,94.6,108.2,108.2,97.4,101.8,105.5,102,87.8,51.7,99.4,101.4,102.3,107.6,105.4,111.7,2549.2,2513.2,2571.8,2291.8,2623,2623,2361.4,2465.9,2556,2471,2126.8,1252,2409,2456.6,2480.1,2607.1,2555.1,2708.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y6A4","Cilia- and flagella-associated protein 20 [OS=Homo sapiens]",38,7,19,7,193,22.8,9.76,47.39,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","","CFAP20","ENSG00000070761","","","",1.2,1.326,1.128,1.193,1.256,101.4,112,95.3,84.5,100.7,106.1,103.1,101.7,101.5,94.8,113.3,112.4,95.3,97.6,95.6,104.6,84.8,73,94.3,101.1,106.8,108,106.5,105.7,2282,2250.5,2246.7,2097.1,2506.2,2487.7,2108.2,2160.6,2115.8,2314.3,1875.6,1614.5,2085.5,2236.8,2362.4,2390.1,2356.2,2337.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9P035","Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 [OS=Homo sapiens]",20,6,51,6,362,43.1,8.94,149.64,"other metabolic processes;signal transduction;other biological processes","other membranes;ER/Golgi;nucleus","enzyme regulator activity;other molecular function","HACD3","ENSG00000074696","Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism","Synthesis of very long-chain fatty acyl-CoAs","",1.202,1.251,1.32,1.315,1.302,97.6,101.6,107.2,81.2,106.8,105.7,92.1,96.4,97.1,100.3,103.5,99.2,106.1,104.1,105.9,80.2,78.8,101.1,104.2,107.1,105.5,104.3,104.4,109.7,5392.3,5641.9,5683.7,5871.6,6057.7,5809.4,6210.8,6097.2,6198.4,4694.4,4615.7,5920.3,6099.9,6270.2,6174.6,6106,6110.2,6425.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P56381","ATP synthase subunit epsilon, mitochondrial [OS=Homo sapiens]",43,3,6,3,51,5.8,9.92,13.51,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity;other molecular function","ATP5F1E","ENSG00000124172","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation",1.206,1.171,1.141,1.218,1.241,103.7,100.7,98.1,86,104.8,106.7,111.1,105.6,105,102.5,97.5,125.4,90.8,104.5,99.9,89,87.5,26,106.6,99.9,111,108.6,124.4,104.6,1332.2,1265.5,1258.1,1228.9,1168.7,1503.1,1088.3,1252.5,1197.7,1066.8,1049.5,311.8,1278.4,1197.4,1330.6,1302,1491.7,1254.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NYK5-1","39S ribosomal protein L39, mitochondrial [OS=Homo sapiens]",39,13,40,13,338,38.7,7.65,106.56,"","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL39","ENSG00000154719","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1.209,1.274,1.242,1.178,1.253,101.4,106.8,104.1,83.8,98.8,105,105.2,102.4,101.6,98.8,108.7,107.9,97.6,105.2,106.1,96,84.7,63.2,98.4,99.8,107.4,106.1,103.2,107.7,4810.3,4682.6,4647.8,4519.7,4968.6,4932.2,4463.5,4808.9,4852.4,4391.3,3872.6,2890.6,4501.6,4563.3,4912.1,4851.4,4719.2,4924.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O95394","phosphoacetylglucosamine mutase [OS=Homo sapiens]",23,14,33,14,542,59.8,6.25,91.25,"protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol","other molecular function","PGM3","ENSG00000013375","Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars","Synthesis of UDP-N-acetyl-glucosamine","Glucuronidation",1.214,1.289,1.207,1.213,1.2,102.3,108.6,101.7,84.2,102.1,101.1,106.6,99.8,102.9,98.9,109.3,119.3,96,102.3,106.7,104.3,84.7,55.6,94.8,102.8,111.8,99.2,103.4,101.7,5427.1,5082.9,5240.9,5036.5,5564.6,6074.3,4887.8,5211.1,5436.2,5312,4315.6,2833,4828,5234.1,5696.6,5050.3,5267.5,5179.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q13868","Exosome complex component Rrp4 [OS=Homo sapiens]",25,6,17,6,293,32.8,7.5,62.26,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","EXOSC2","ENSG00000130713","RNA degradation","ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; Major pathway of rRNA processing in the nucleolus and cytosol; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease","Ciliary landscape",1.217,1.363,1.244,1.161,1.304,100.1,112.2,102.4,82.3,95.6,107.4,100.1,104.9,101.5,93.2,113.8,115.3,94.4,103.8,105.3,96.5,83.4,58.2,96.9,95.4,111,105.5,108.8,111.8,1315.2,1377.8,1333.5,1224.8,1494.2,1514.9,1240.3,1363.5,1382.9,1268,1095.9,764.6,1272.6,1253.2,1458.4,1385.8,1429.4,1468,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q15468-1","SCL-interrupting locus protein [OS=Homo sapiens]",1,1,1,1,1287,142.9,6.46,1.9,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","other molecular function","STIL","ENSG00000123473","","","",1.22,1.261,1.099,1.178,1.185,105.5,108.9,95,86.4,101.8,102.4,112.8,99.9,108.9,112.5,120.7,87.6,91.8,98.1,102.5,89.4,89.3,82.7,93.5,106.4,105.2,105.8,83.9,109.1,77.9,69,75.2,77.7,83.3,60.5,63.4,67.7,70.8,61.7,61.6,57.1,64.6,73.5,72.6,73,57.9,75.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q7Z6E9","E3 ubiquitin-protein ligase RBBP6 [OS=Homo sapiens]",19,35,71,35,1792,201.4,9.64,188.58,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","RBBP6","ENSG00000122257","","Antigen processing: Ubiquitination & Proteasome degradation; RHOBTB1 GTPase cycle","",1.225,1.171,1.177,1.167,1.157,106.6,101.9,102.4,87,101.5,100.6,106.5,106.4,106.6,102.8,100.3,101.8,103.9,102.4,102.3,85.4,88.3,86.9,101.4,100.2,104.9,101.3,98.2,100.6,7595.2,7590.2,7601.1,7329.5,7150.3,7263.2,7407.2,7301.1,7295.9,6091.1,6295.4,6201.2,7233.9,7144.5,7482.1,7222.8,7003.7,7173.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H7D7","WD repeat-containing protein 26 [OS=Homo sapiens]",21,13,23,13,661,72.1,6.16,69.88,"","cytosol;mitochondrion;nucleus;other cell component","","WDR26","ENSG00000162923","","","Ciliary landscape",1.233,1.207,1.155,1.087,1.075,109.5,107.2,102.6,88.8,96.5,95.4,108,107.8,107.5,105.5,105,106.8,100.4,101,101.2,87.4,84.9,116.4,94,96.7,95,93,94,95.3,2422.8,2417.8,2411.6,2366.1,2354.2,2395.6,2252.6,2264.5,2268.6,1961.1,1904.5,2611.1,2107.7,2168,2131.3,2085.1,2107.4,2136.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8NBM8","Prenylcysteine oxidase-like [OS=Homo sapiens]",6,4,11,4,494,54.6,7.31,24.67,"protein metabolism;other metabolic processes","non-structural extracellular;other cell component","other molecular function","PCYOX1L","ENSG00000145882","","Platelet degranulation","",1.238,1.271,1.259,1.235,1.263,102.2,105,104,82.6,102,104.3,100.7,104.6,103.5,105.8,106.3,113.8,104.4,105.4,105.2,86.3,83.6,51.2,99.8,103.2,108.9,109.4,105.6,102.4,1056.6,1097.6,1085.6,1110.2,1114.7,1193.8,1094.9,1105.1,1103.9,905.7,876.8,536.9,1046.9,1082.9,1141.9,1147.5,1107.3,1073.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q7Z7H8","39S ribosomal protein L10, mitochondrial [OS=Homo sapiens]",33,5,16,5,261,29.3,9.58,50.63,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus;other cell component","other molecular function","MRPL10","ENSG00000159111","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1.242,1.343,1.266,1.246,1.268,101.2,109.4,103.1,81.5,101.5,103.3,97.7,100.1,103.7,107.1,108.2,109.3,101.3,102,111,86.1,79.4,80.6,97.6,100.4,106.9,102.2,97.1,109.3,1283.6,1314.7,1362.5,1406.9,1421.2,1436.3,1330.8,1339.3,1458.6,1131.5,1042.9,1058.3,1282,1318.4,1404.4,1341.9,1275.7,1435.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q04917","14-3-3 protein eta [OS=Homo sapiens]",67,15,369,11,246,28.2,4.84,1056.23,"other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","YWHAH","ENSG00000128245","Cell cycle; Oocyte meiosis; PI3K-Akt signaling pathway; Hippo signaling pathway; Hepatitis C; Viral carcinogenesis","Translocation of SLC2A4 (GLUT4) to the plasma membrane; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; Activation of BAD and translocation to mitochondria","Cell cycle; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways",1.248,1.251,1.168,1.195,1.229,105.6,105.9,98.9,84.6,101.1,104,108.1,106.6,105.3,101.5,106.9,108.2,94.6,99.9,103.8,92.9,85.5,65.6,102.1,100.6,105,105,102.9,105.6,23582.8,23273.5,22971.2,22161.1,23336.3,23623.3,20650.7,21792.4,22645.7,20267.5,18650.6,14319.6,22278.8,21946.7,22910.7,22913.6,22465.1,23052.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P08603-1","complement factor H [OS=Homo sapiens]",1,1,2,1,1231,139,6.61,5.3,"stress response;other biological processes","non-structural extracellular","other molecular function","CFH","ENSG00000000971","Complement and coagulation cascades; Staphylococcus aureus infection","Regulation of Complement cascade","Complement system; Complement system in neuronal development and plasticity; Network map of SARS-CoV-2 signaling pathway; Complement and coagulation cascades",1.249,1.12,1.165,1.103,1.006,112.8,101.2,105.2,90.3,99.7,90.8,112,100.4,115.1,106.5,100.5,95.5,104.5,111.4,92.7,89.7,101.1,80.5,92.7,99,111.2,86.5,90.2,110.6,99.2,88.9,101.9,94.3,89,84.6,92.6,98.7,82.1,79.5,89.6,71.3,82.1,87.7,98.5,76.6,79.9,98,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UHB7-1","AF4/FMR2 family member 4 [OS=Homo sapiens]",10,9,12,9,1163,127.4,9.31,24.62,"other biological processes","nucleus;other cell component","","AFF4","ENSG00000072364","","RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex","",1.262,1.194,1.11,1.061,1.016,114,107.8,100.2,90.3,95.8,91.8,112.4,107.7,111.5,104.6,108.8,105.5,106.1,98.1,96.3,85.6,88.4,115.6,93.1,93.8,99.5,89.8,94.8,88.5,670.8,642.7,665.4,624,649.1,629.5,632.8,585.3,574.6,510.8,527.4,689.4,555.3,559.5,593.6,535.8,565.4,527.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NY59","Sphingomyelin phosphodiesterase 3 [OS=Homo sapiens]",8,2,2,2,655,71,5.78,2.66,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","SMPD3","ENSG00000103056","Sphingolipid metabolism; Metabolic pathways","Glycosphingolipid metabolism; TNFR1-mediated ceramide production","Sphingolipid metabolism in senescence",1.267,1.227,1.343,1.189,1.185,105.4,102.1,111.7,83.2,99,98.6,83.2,115.1,109.8,117.7,106.4,88.2,116.4,121.5,88.8,86.7,91.5,65.3,92.6,103.1,105.4,101.7,103.8,102.7,22.5,31.1,29.6,31.8,28.7,23.8,31.4,32.8,24,23.4,24.7,17.6,25,27.8,28.5,27.4,28,27.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q32M88","protein-glucosylgalactosylhydroxylysine glucosidase [OS=Homo sapiens]",4,2,3,2,737,80.6,5.25,4.4,"other metabolic processes","cytosol","other molecular function","PGGHG","ENSG00000142102","","","",1.275,1.388,1.208,1.264,1.243,103.7,112.9,98.2,81.3,102.8,101.1,90.7,106.8,103,95.7,116.8,112.1,94.6,97.5,110.9,91.1,80.8,80.1,102.1,101.5,110.8,99.5,105.8,100.4,195.2,229.9,221.7,206.1,251.6,241.4,203.6,210,238.8,196.2,173.9,172.4,219.7,218.5,238.6,214.2,227.8,216.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P14635","G2/mitotic-specific cyclin-B1 [OS=Homo sapiens]",14,5,14,5,433,48.3,7.47,23.72,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","CCNB1","ENSG00000134057","FoxO signaling pathway; Cell cycle; Oocyte meiosis; p53 signaling pathway; Cellular senescence; Progesterone-mediated oocyte maturation; Human immunodeficiency virus 1 infection","The role of GTSE1 in G2/M progression after G2 checkpoint; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Resolution of Sister Chromatid Cohesion; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; APC/C:Cdc20 mediated degradation of Cyclin B; Phosphorylation of the APC/C; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Cyclin A/B1/B2 associated events during G2/M transition; Transcriptional regulation by RUNX2; MASTL Facilitates Mitotic Progression; E2F-enabled inhibition of pre-replication complex formation; Golgi Cisternae Pericentriolar Stack Reorganization; Condensation of Prophase Chromosomes; Initiation of Nuclear Envelope (NE) Reformation; Polo-like kinase mediated events; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint; Depolymerisation of the Nuclear Lamina; Phosphorylation of Emi1","AMP-activated protein kinase (AMPK) signaling; miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; ATM signaling pathway; G1 to S cell cycle control; DNA damage response",1.285,1.173,1.186,1.341,1.147,108.1,98.7,99.7,84.1,112.9,96.5,108.6,110.1,105.2,95.3,100.6,99.2,97.2,100.2,102.1,84.5,80.3,91.8,105.2,113.4,115.5,92.7,97,101.2,1390.6,1409.9,1346.9,1219.5,1288.3,1269.8,1244.4,1283.2,1307.7,1082.3,1027.5,1174.7,1346.4,1451.9,1478.5,1186.4,1241.4,1295.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["L0R6Q1","SLC35A4 upstream open reading frame protein [OS=Homo sapiens]",47,5,18,5,103,11.1,8.1,62.31,"stress response","other membranes","","SLC35A4","ENSG00000176087","","","",1.289,1.299,1.177,1.34,1.355,103.7,104.5,94.6,80.4,107.8,109,95.2,103.6,110,102.1,104.4,112.3,92.8,94.6,106.8,80.4,95.3,60.6,107.7,103.4,108.2,114.5,108.9,98.9,2248.3,2447.5,2599.3,2412.6,2466.9,2652.2,2192.5,2234.3,2523.9,1898.8,2251.4,1431.4,2545,2443.5,2556.9,2705.6,2573.2,2335.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P02042","Hemoglobin subunit delta [OS=Homo sapiens]",13,2,25,1,147,16,8.05,63.89,"other metabolic processes;transport;other biological processes","cytosol;other cell component","other molecular function","HBD","ENSG00000223609","","Factors involved in megakaryocyte development and platelet production","VEGFA-VEGFR2 signaling pathway",1.308,1.354,1.353,1.339,1.375,101.5,105.1,105.1,77.6,104,106.8,103.3,98.8,100.1,103.6,120.6,101.6,103.6,87.6,103.6,76.5,91,73.9,115.3,102.5,102.1,108.4,105.3,102.2,959.5,917.9,929.6,962.3,1120,943.2,962.2,813.1,962.1,710.8,844.7,685.9,1071.1,952,948.5,1006.8,977.6,948.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UHA4","ragulator complex protein LAMTOR3 [OS=Homo sapiens]",14,2,14,2,124,13.6,7.34,36.24,"other biological processes","plasma membrane;other membranes;other cytoplasmic organelle","enzyme regulator activity","LAMTOR3","ENSG00000109270","MAPK signaling pathway; mTOR signaling pathway","Regulation of PTEN gene transcription; Neutrophil degranulation; MAP2K and MAPK activation; TP53 Regulates Metabolic Genes; Amino acids regulate mTORC1; mTORC1-mediated signalling; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK","MAPK signaling pathway; MAPK cascade; Gastrin signaling pathway; Melanoma",1.312,1.396,1.212,1.194,1.281,106.4,113.3,98.3,81.1,96.9,103.9,106,105.8,106.3,96.9,112.8,116.6,89.5,97.9,110.4,97.7,80.8,77.9,96.5,88.5,104.1,103.5,106.2,102.7,1888.6,1884.5,1892.9,1725.5,2009.3,2077,1594.9,1744.7,1966.4,1741.1,1439.3,1387.5,1719,1576.5,1855.5,1844,1891.6,1829.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UKR5","probable ergosterol biosynthetic protein 28 [OS=Homo sapiens]",21,3,7,3,140,15.9,9.83,16.15,"other metabolic processes","other membranes;ER/Golgi","other molecular function","ERG28","ENSG00000133935","","","",1.326,1.463,1.353,1.351,1.395,100.8,111.3,102.9,76.1,102.8,106.1,103.8,104.4,93.6,100.5,114.5,117.5,103.8,107.6,105.9,89.4,78.3,38.3,103.6,105.8,111.1,109.4,103.3,109.2,480.2,483.3,433.3,465.3,529.8,544,480.4,498.1,490.2,413.9,362.2,177.4,479.7,489.5,514,506.2,478.3,505.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q06481","Amyloid-like protein 2 [OS=Homo sapiens]",4,4,4,4,763,86.9,4.79,8.09,"signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","APLP2","ENSG00000084234","","Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","Splicing factor NOVA regulated synaptic proteins",1.332,1.321,1.277,1.269,1.17,108.5,107.5,104,81.4,103.3,95.3,106.7,109.7,107.8,106.9,108,99.3,103.4,102,105.1,80.9,80.2,108.5,98.4,102.7,103.1,94.7,87.2,95.4,600.1,617,606.2,600.9,607,558.4,581.1,573.3,590.9,455,450.7,610.3,553,577.5,579.5,532.4,490.2,536.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P02765","Alpha-2-HS-glycoprotein [OS=Homo sapiens]",5,3,23,3,367,39.3,5.72,66.88,"","","","","","","","",1.352,1.361,1.206,1.377,1.172,108.7,109.3,96.9,80.3,110.6,94.2,105.7,109.4,114.5,115.1,68.3,110.1,91.4,97.5,118.5,80.9,128.1,38.2,111.4,116.7,103.5,94.8,103.5,92.5,4226.8,4372.4,4576.3,4601.1,2730.4,4399.6,3652.5,3898.3,4737.1,3233.2,5121.5,1528.1,4451.2,4663.4,4137.9,3789.5,4136.7,3695.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96HE9","Proline-rich protein 11 [OS=Homo sapiens]",2,1,2,1,360,40.1,10.11,4.55,"other biological processes","nucleus;other cell component","","PRR11","ENSG00000068489","","","",1.371,1.221,1.378,1.421,1.44,105.1,93.6,105.6,76.6,108.9,110.3,113.6,106.5,101.3,99.8,94.9,90.7,102.8,107,107.7,83.1,77.7,37.1,109.8,118.6,110.4,111.8,106.6,120.6,246.5,231.1,219.9,216.6,205.9,196.8,223,232.2,233.6,180.4,168.6,80.5,238.2,257.4,239.5,242.7,231.3,261.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P36542-1","ATP synthase subunit gamma, mitochondrial [OS=Homo sapiens]",45,15,150,14,298,33,9.22,281.01,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","ATP5F1C","ENSG00000165629; ENSGGOG00000009719; ENSPPAG00000007094; ENSPTRG00000002277","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria",1.372,1.347,1.426,1.305,1.404,104.8,102.9,108.9,76.4,99.7,107.2,103.5,106.9,106.2,104.2,101.4,109,97.3,110.5,110.4,84.3,77.4,58.9,101,96.2,110.1,109.2,104.9,108.6,14770.2,15249,15154,14873,14466.2,15556.6,13883.8,15762.6,15747.1,12030.9,11043.4,8405.6,14412.3,13722.7,15703.5,15586.6,14972.3,15501.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BUV8-1","Uncharacterized protein C20orf24 [OS=Homo sapiens]",16,2,4,2,137,15.5,5.2,11.87,"cell organization and biogenesis","other membranes;mitochondrion","","RAB5IF","ENSANAG00000024895; ENSG00000101084; ENSNLEG00000035359; ENSPTRG00000013460","","","",1.374,1.194,1.156,1.41,1.2,112.4,97.7,94.6,81.8,115.4,98.2,116.4,97.5,117.9,91.6,109.4,101.2,100.3,94.6,98,90.2,84.8,63.8,93.5,119.5,124.6,87.7,101.7,107.4,412.4,345.3,417.6,324.4,387.7,358.4,355.4,335,347.1,319.7,300.3,225.9,331.4,423.3,441.3,310.6,360.3,380.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96FX8","p53 apoptosis effector related to PMP-22 [OS=Homo sapiens]",13,1,1,1,193,21.4,7.03,4.59,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cell component","","PERP","ENSG00000112378","p53 signaling pathway","Formation of the cornified envelope; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain","miRNA regulation of p53 pathway in prostate cancer; p53 transcriptional gene network",1.376,1.166,1.247,1.351,1.214,112.3,95.1,101.7,81.6,110.2,99.1,121.1,113.5,83.7,139.7,96.2,70.3,109.3,102.8,87.8,97.7,82.4,53.4,102.6,111.4,149.7,121.3,100.1,57.1,16.5,15.5,11.4,19,13.1,9.6,14.9,14,12,13.3,11.2,7.3,14,15.2,20.4,16.5,13.6,7.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q14643-1","Inositol 1,4,5-trisphosphate receptor type 1 [OS=Homo sapiens]",2,5,7,1,2758,313.7,6.04,15.29,"stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","ITPR1","ENSG00000150995","Calcium signaling pathway; cGMP-PKG signaling pathway; Phosphatidylinositol signaling system; Oocyte meiosis; Autophagy; Apoptosis; Cellular senescence; Vascular smooth muscle contraction; Apelin signaling pathway; Gap junction; Platelet activation; NOD-like receptor signaling pathway; C-type lectin receptor signaling pathway; Circadian entrainment; Long-term potentiation; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; Dopaminergic synapse; Long-term depression; Inflammatory mediator regulation of TRP channels; GnRH signaling pathway; Estrogen signaling pathway; Thyroid hormone synthesis; Oxytocin signaling pathway; Glucagon signaling pathway; Renin secretion; Aldosterone synthesis and secretion; Cortisol synthesis and secretion; Parathyroid hormone synthesis, secretion and action; GnRH secretion; Cushing syndrome; Growth hormone synthesis, secretion and action; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Alzheimer disease; Parkinson disease; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Shigellosis; Human cytomegalovirus infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Proteoglycans in cancer; Lipid and atherosclerosis","PLC beta mediated events; Ca2+ pathway; VEGFR2 mediated cell proliferation; FCGR3A-mediated IL10 synthesis; Ion homeostasis; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Role of phospholipids in phagocytosis; DAG and IP3 signaling; Effects of PIP2 hydrolysis; FCERI mediated Ca+2 mobilization; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; cGMP effects; Elevation of cytosolic Ca2+ levels; CLEC7A (Dectin-1) induces NFAT activation","Alzheimer's disease and miRNA effects; Myometrial relaxation and contraction pathways; G protein signaling pathways; Cell-type dependent selectivity of CCK2R signaling; Genotoxicity pathway; Resistin as a regulator of inflammation; Fragile X syndrome; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Vitamin D-sensitive calcium signaling in depression; PKC-gamma calcium signaling pathway in ataxia; Type I collagen synthesis in the context of osteogenesis imperfecta; STING pathway in Kawasaki-like disease and COVID-19; Alzheimer's disease; Calcium regulation in cardiac cells; T-cell receptor (TCR) signaling pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling",1.377,1.214,1.316,1.321,1.345,109.1,96.2,104.3,79.2,104.7,106.6,111.1,84.6,96.3,75.5,95.1,84.9,92,92.1,89.6,69.7,69.9,271.6,87,92.4,97.4,91.3,94.1,105.6,76.2,58,66.1,51.8,65.2,58.3,63.2,63.2,61.5,47.8,48,186.4,59.7,63.4,66.8,62.7,64.6,72.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P55316","Forkhead box protein G1 [OS=Homo sapiens]",2,1,2,1,489,52.3,8.87,2.02,"cell organization and biogenesis;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","FOXG1","ENSG00000176165","FoxO signaling pathway","FOXO-mediated transcription of cell cycle genes; Regulation of MECP2 expression and activity","MECP2 and associated Rett syndrome; Tgif disruption of Shh signaling; Rett syndrome causing genes",1.377,1.378,1.195,1.187,1.182,112.9,113,98,82,97.3,96.9,113.3,99.4,114.3,122.7,85.9,113.4,93.6,98.3,105.2,82.3,97.2,69.7,93.8,97.6,119.3,95.1,101.5,97.3,292.3,256.5,295,316.6,221.6,292.5,241.5,253.7,271.5,212.3,250.7,179.7,242,251.9,307.9,245.4,261.8,251,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q86XP1","Diacylglycerol kinase eta [OS=Homo sapiens]",1,1,1,1,1220,134.8,6.54,2.95,"other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","DGKH","ENSG00000102780","Glycerolipid metabolism; Glycerophospholipid metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Phospholipase D signaling pathway; Choline metabolism in cancer","Effects of PIP2 hydrolysis","",1.377,1.473,1.502,1.492,1.418,100,107,109.1,72.6,108.3,103,102.2,107.5,101.4,102.1,109.4,132.4,88.4,111.5,116,91.2,74.2,21.1,110.8,92,120.9,114.3,105.3,99.1,94,98.8,93.2,93.9,100.5,121.7,81.3,102.5,106.6,83.8,68.2,19.4,101.8,84.6,111.1,105.1,96.8,91.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6IPR3-1","tRNA wybutosine-synthesizing protein 3 homolog [OS=Homo sapiens]",10,2,4,2,259,29.8,7.68,2.66,"RNA metabolism OR transcription;other metabolic processes","other cell component","other molecular function","TYW3","ENSG00000162623","","Synthesis of wybutosine at G37 of tRNA(Phe)","",1.378,1.33,1.31,1.362,1.342,107.1,103.4,101.8,77.7,105.8,104.2,105.9,104.7,97.1,101.1,98,120.2,99.7,98.9,99.6,88.6,75.2,76,103.4,94.6,114.8,98.6,121.9,101.9,113.7,112.4,104.2,108.5,105.2,129.1,107,106.1,106.9,95.1,80.7,81.6,111,101.6,123.2,105.8,130.8,109.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O60292","Signal-induced proliferation-associated 1-like protein 3 [OS=Homo sapiens]",1,1,1,1,1781,194.5,8.32,2.87,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","enzyme regulator activity","SIPA1L3","ENSG00000105738","Rap1 signaling pathway","","",1.378,1.5,1.216,1.183,1.136,111.6,121.4,98.4,80.9,95.8,92,112.5,98,128,145.7,104.3,122.4,92.9,122.2,99.2,82.1,81.6,63.6,112,63.1,96.5,104.5,78.7,92.7,29.1,25.4,33.1,37.7,27,31.7,24,31.6,25.7,21.3,21.1,16.5,29,16.3,25,27.1,20.4,24,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BUN8","Derlin-1 [OS=Homo sapiens]",13,3,8,3,251,28.8,9.51,25.56,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","signal transduction activity or receptor binding;other molecular function","DERL1","ENSG00000136986","Protein processing in endoplasmic reticulum; Amyotrophic lateral sclerosis; Pathways of neurodegeneration","ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; E3 ubiquitin ligases ubiquitinate target proteins; N-glycan trimming in the ER and Calnexin/Calreticulin cycle","Amyotrophic lateral sclerosis (ALS)",1.379,1.46,1.423,1.393,1.34,103.5,109.6,106.8,75,104.5,100.6,102.5,105.9,115.5,112.1,81.9,114.6,93.7,109.2,111.5,76.8,97,47,104.1,106.9,109.8,102.9,111.9,96.8,1351.6,1396.9,1524.4,1478.4,1080.1,1511.3,1236.2,1441.2,1471.2,1012.7,1279.8,620,1374,1410.4,1448.1,1357.6,1476.4,1276.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8N488","RING1 and YY1-binding protein [OS=Homo sapiens]",30,5,8,5,228,24.8,9.63,24.08,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RYBP","ENSG00000163602","","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Transcriptional Regulation by E2F6","",1.379,1.355,1.376,1.331,1.3,106.9,105,106.6,77.5,103.2,100.7,105.8,107.6,108.8,118.2,105.7,93.9,107.3,103.9,113.7,78,86.1,55.2,103.8,106.2,100.4,101.4,100,103.9,738,750.4,759.1,824.7,737.4,655.1,748.5,724.6,793.3,544,600.8,385.1,724.3,740.4,700.3,707,697.9,724.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P12429","annexin A3 [OS=Homo sapiens]",2,1,2,1,323,36.4,5.92,1.96,"stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","enzyme regulator activity;other molecular function","ANXA3","ENSG00000138772","","","Prostaglandin synthesis and regulation",1.38,1.419,1.321,1.274,1.404,106.2,109.2,101.6,76.9,98,108,97.3,106.3,101.8,102.6,121.7,104.6,80.7,97.4,124.7,73.7,56,142.1,93.9,71.3,123.2,103.5,91.7,107.5,174.7,190.8,182.7,184.1,218.4,187.8,144.9,174.8,223.8,132.3,100.5,255,168.6,128,221.1,185.8,164.6,193,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H0U6","39S ribosomal protein L18, mitochondrial [OS=Homo sapiens]",13,2,5,2,180,20.6,9.54,11.81,"protein metabolism;other metabolic processes;transport","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL18","ENSG00000112110","Ribosome","Mitochondrial translation elongation; Mitochondrial translation initiation; Mitochondrial translation termination","",1.381,1.028,1.078,1.2,1.261,119.2,88.8,93.1,86.4,103.6,108.9,118.8,112.9,117.1,87.2,81.5,143.9,78,91.5,101.5,98.1,84.8,41.3,101.8,89.4,109,106.9,141.9,94.4,457.9,435.1,451.3,336,314.1,554.7,300.5,352.5,391.2,378.3,326.9,159.1,392.3,344.5,420.3,412.1,547,364,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8NEY4-1","V-type proton ATPase subunit C 2 [OS=Homo sapiens]",6,2,3,1,427,48.7,6.14,7.91,"transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle","transporter activity;other molecular function","ATP6V1C2","ENSG00000143882; ENSGGOG00000002273; ENSPPAG00000028894; ENSPTRG00000011652","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis","ROS and RNS production in phagocytes; Amino acids regulate mTORC1; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","",1.381,1.125,1.209,1.316,1.463,110.6,90,96.8,80.1,105.4,117.1,97.1,108,149.7,84.5,87.9,110.7,107.6,80.6,94.5,51.2,78.2,99.3,102.9,117.2,80.1,102.6,114.3,133.6,14.7,16.3,22.6,12.8,13.3,16.7,16.2,12.2,14.3,7.7,11.8,15,15.5,17.7,12.1,15.5,17.3,20.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6UXN9","WD repeat-containing protein 82 [OS=Homo sapiens]",9,3,3,3,313,35.1,7.69,5.91,"protein metabolism;other metabolic processes","nucleus;other cell component","other molecular function","WDR82","ENSG00000164091","mRNA surveillance pathway","","",1.385,1.516,1.303,1.288,1.283,106.9,117,100.5,77.2,99.4,99,112,109.1,107.6,109,119.4,132.8,89.7,102.7,104.4,88.6,78.8,32.8,95.3,101.5,113.5,102,99.9,101.1,513.2,500,492.7,499.3,547,608.1,410.8,470.2,478.2,406,360.9,150.5,436.4,464.8,519.8,467.1,457.4,463,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O43924","Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [OS=Homo sapiens]",25,3,5,3,150,17.4,5.67,16.56,"other biological processes","other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","PDE6D","ENSG00000156973","Purine metabolism; Metabolic pathways","ARL13B-mediated ciliary trafficking of INPP5E; RAS processing","Phosphodiesterases in neuronal function; Joubert syndrome; Ciliopathies",1.386,1.377,0.901,1.024,1.039,123.7,122.8,80.3,89.2,91.4,92.7,127.1,117,124,124.5,122.3,123.2,80.6,73.9,82,95.3,88.5,89.5,95.6,90.6,91.6,93,93,88.3,752.3,692.5,734.1,736.5,723.7,729,476.8,437.3,485,564.2,523.5,529.5,565.9,536.2,542.3,550.2,550.3,522.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q5T9A4","ATPase family AAA domain-containing protein 3B [OS=Homo sapiens]",32,24,158,3,648,72.5,9.2,477.34,"cell organization and biogenesis","plasma membrane;other membranes;mitochondrion","other molecular function","ATAD3B","ENSG00000160072","","Neutrophil degranulation","",1.388,1.324,1.372,1.298,1.269,108.8,103.8,107.6,78.4,101.8,99.5,111.6,104.5,111.4,106.2,84.3,113.2,100.1,110.1,118.7,80.3,82.7,47,101.3,104.2,112.3,109.3,101.9,101.1,905.7,848.3,903.9,862.1,684.1,918.9,812.1,893.7,963.1,651.4,671.1,381.1,822.4,845.7,911.3,887,826.7,820.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O15534-1","period circadian protein homolog 1 [OS=Homo sapiens]",2,2,2,2,1290,136.1,6.09,0,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PER1","ENSG00000179094","Circadian rhythm; Circadian entrainment","Circadian Clock","Melatonin metabolism and effects; Exercise-induced circadian regulation",1.392,1.436,1.346,1.391,1.26,106.8,110.1,103.2,76.7,106.7,96.6,98.7,101.4,113.1,104.6,93.4,113.7,82.1,98,111.8,72.7,72.8,159.3,92.6,101.3,107.1,91.7,95.5,89.9,179.8,184.6,206,190.4,170.1,207,149.4,178.5,203.6,132.4,132.6,290.1,168.5,184.5,195.1,167,173.9,163.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O43283","Mitogen-activated protein kinase kinase kinase 13 [OS=Homo sapiens]",2,1,1,1,966,108.2,6.49,0,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;other cell component","kinase activity;other molecular function","MAP3K13","ENSG00000073803","MAPK signaling pathway","","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Insulin signaling",1.397,1.348,1.326,1.346,1.361,107.7,104,102.3,77.1,103.8,105,91.8,110.3,111,110.3,106.5,105.6,94.2,106.4,104.7,79,105.1,19.3,120.5,100.5,106.3,113.8,107.5,107.3,236.4,284,285.7,284.2,274.1,271.8,242.6,274.1,269.7,203.3,270.6,49.8,310.4,258.8,273.7,293.1,276.8,276.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BXS6","Nucleolar and spindle-associated protein 1 [OS=Homo sapiens]",29,11,15,11,441,49.4,9.91,42.77,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity","NUSAP1","ENSG00000137804","","","",1.401,1.322,1.289,1.321,1.188,111.8,105.5,102.8,79.8,105.4,94.8,108.8,114.2,112.1,105.8,102.6,107.9,103.1,104.5,102.7,78.4,83.3,80,107.4,103.7,105.7,95.1,95.4,89.3,2246.2,2356.3,2313.5,2183.6,2117.1,2226.4,2128.4,2157.5,2120.4,1617,1718.8,1651.4,2217.2,2140.1,2181.3,1962.2,1968.4,1842.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q14693-1","Phosphatidate phosphatase LPIN1 [OS=Homo sapiens]",28,16,35,16,890,98.6,6.58,83.8,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","LPIN1","ENSG00000134324","Glycerolipid metabolism; Glycerophospholipid metabolism; Metabolic pathways; mTOR signaling pathway; Alcoholic liver disease","Triglyceride biosynthesis; Depolymerisation of the Nuclear Lamina; Synthesis of PC; Synthesis of PE","Sterol regulatory element-binding proteins (SREBP) signaling; Adipogenesis; Transcription factor regulation in adipogenesis; Congenital generalized lipodystrophy (CGL)",1.401,1.302,1.279,1.189,1.203,114,105.9,104,81.4,96.7,97.9,112.8,114.3,114,104.7,110.2,105.9,98.7,104,105.3,81.3,78.3,82,96.7,96.6,103.2,98,96.2,97.8,3502.5,3549.5,3540.2,3251.9,3422.2,3287.8,3064.4,3229.7,3270.4,2526.1,2432.1,2548,3002.3,2999,3205.8,3042,2987.6,3038.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H7P6","Multivesicular body subunit 12B [OS=Homo sapiens]",7,1,1,1,319,35.6,8.15,4.5,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MVB12B","ENSG00000196814","Endocytosis","Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Late endosomal microautophagy","",1.402,1.805,1.633,1.673,1.774,90.6,116.6,105.5,64.6,108.1,114.6,87.7,84,114,111.6,112.9,139.4,105.7,94.2,102.1,92.4,62.6,51.3,72.8,104.7,119.9,108,125.7,111,42.4,40.7,55.2,54,54.7,67.5,51.2,45.6,49.4,44.7,30.3,24.9,35.3,50.7,58,52.3,60.8,53.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P33897","ATP-binding cassette sub-family D member 1 [OS=Homo sapiens]",3,2,3,2,745,82.9,8.95,5.39,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ABCD1","ENSG00000101986","ABC transporters; Peroxisome","Class I peroxisomal membrane protein import; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of very long chain fatty acids; Linoleic acid (LA) metabolism; ABC transporters in lipid homeostasis; Defective ABCD1 causes ALD","Vitamin D receptor pathway",1.403,1.469,1.409,1.403,1.276,105.8,110.7,106.2,75.4,105.8,96.2,108.4,106.5,101.9,113.7,111.5,109.4,106.9,110,97.2,75.9,69.3,81.3,106.5,109.6,99.2,96.1,96.8,99.9,341.8,335.8,321.5,358.7,351.6,344.9,337.2,347,306.5,239.3,218.6,256.3,335.9,345.8,313.1,303.2,305.3,315.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NXS2","Glutaminyl-peptide cyclotransferase-like protein [OS=Homo sapiens]",13,5,16,5,382,42.9,9.82,36.94,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","QPCTL","ENSG00000011478","","","",1.407,1.279,1.378,1.395,1.322,108.5,98.6,106.3,77.1,107.5,102,109.1,106.6,108.4,102.7,97.5,98.6,106.2,102.8,107.3,77.1,91.7,68.9,107.5,111.4,104.4,102.1,95.9,101.9,2056,2009,2041.9,1935.4,1836,1856.9,2000.9,1937,2021.9,1451.7,1728.3,1297.7,2024.7,2098.7,1967.1,1922.8,1806,1919.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q93099","Homogentisate 1,2-dioxygenase [OS=Homo sapiens]",2,1,2,1,445,49.9,6.96,5.96,"other metabolic processes","cytosol;other cell component","other molecular function","HGD","ENSG00000113924","Tyrosine metabolism; Metabolic pathways","Tyrosine catabolism","",1.409,1.807,1.602,1.62,1.709,92.4,118.5,105.1,65.6,106.3,112.1,90.6,100.7,91.2,103.6,117,140.2,103.7,99.4,107.4,87.4,64.8,28.7,93.7,104.9,129.6,102.6,123.8,110.6,196.8,218.7,198.2,224.9,254.1,304.6,225.2,215.8,233.3,189.9,140.6,62.3,203.4,227.9,281.5,222.7,268.8,240.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P07738","Bisphosphoglycerate mutase [OS=Homo sapiens]",25,5,10,5,259,30,6.54,30.89,"other metabolic processes;developmental processes;other biological processes","cytosol","other molecular function","BPGM","ENSG00000172331","Glycolysis / Gluconeogenesis; Glycine, serine and threonine metabolism; Metabolic pathways","Glycolysis","IL-18 signaling pathway",1.41,1.403,1.353,1.293,1.378,108,107.4,103.6,76.6,99,105.5,108.3,106.4,109.6,111.1,92.2,107.7,97.1,103.9,118.7,76.8,81.3,76.4,99.3,102.5,97.9,105.8,106.8,98.1,1001.6,983.9,1013.5,1027.6,852.5,996.1,898,960.7,1098,710.2,751.3,706.7,918.2,948.1,904.8,978.5,987.3,907.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P55273","Cyclin-dependent kinase 4 inhibitor D [OS=Homo sapiens]",4,1,1,1,166,17.7,6.13,1.72,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","CDKN2D","ENSG00000129355","FoxO signaling pathway; Cell cycle","Oxidative Stress Induced Senescence; Oncogene Induced Senescence; Cyclin D associated events in G1; Senescence-Associated Secretory Phenotype (SASP)","Cell cycle; Vitamin D receptor pathway; G1 to S cell cycle control",1.414,1.346,1.283,1.417,1.344,108.7,103.5,98.6,76.9,108.9,103.3,104.7,109,116,103.8,111.3,99.9,107.5,98.9,89.1,59,84,77.1,120.7,96.4,109.2,111.5,98.4,103.6,46.3,48.2,51.3,45.9,49.3,44.2,47.5,43.7,39.4,26.1,37.1,34.1,53.4,42.7,48.3,49.3,43.5,45.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P20393","nuclear receptor subfamily 1 group D member 1 [OS=Homo sapiens]",1,1,1,1,614,66.8,8.5,1.98,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NR1D1","ENSG00000126368","Circadian rhythm","Transcriptional activation of mitochondrial biogenesis; PPARA activates gene expression; Heme signaling; Nuclear Receptor transcription pathway; NR1D1 (REV-ERBA) represses gene expression","",1.415,1.288,1.461,1.61,1.606,101.3,92.2,104.6,71.6,115.3,115,92.8,100,100.8,91,84.1,105.9,96,105.5,103.2,70.7,65.1,115.8,101.2,113.8,116.7,113.5,118.9,105.2,91.5,98.6,99.3,89.7,82.9,104.3,94.6,104,101.8,69.6,64.2,114.1,99.8,112.1,115,111.9,117.2,103.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P20292","Arachidonate 5-lipoxygenase-activating protein [OS=Homo sapiens]",8,1,1,1,161,18.1,8.44,0,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","other membranes;cytosol;ER/Golgi;nucleus","enzyme regulator activity;other molecular function","ALOX5AP","ENSG00000132965","Fc epsilon RI signaling pathway","Synthesis of 5-eicosatetraenoic acids; Synthesis of Leukotrienes (LT) and Eoxins (EX); Synthesis of Lipoxins (LX)","Selenium micronutrient network; Eicosanoid synthesis; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Prostaglandin and leukotriene metabolism in senescence",1.418,1.634,1.864,1.097,1.179,103.9,119.7,136.5,73.3,80.3,86.4,104.1,82.5,103.3,89.7,145.4,119,71.7,136,135.7,68.3,72.8,151.2,79.9,78.1,82.8,85.9,72.6,121.2,21.2,16.8,21,18.3,29.6,24.3,14.6,27.7,27.7,13.9,14.8,30.8,16.3,15.9,16.9,17.5,14.8,24.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BTX3","Transmembrane protein 208 [OS=Homo sapiens]",20,2,4,2,173,19.6,9.26,15.63,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","TMEM208","ENSG00000168701","","","",1.419,1.789,1.582,1.548,1.633,94.9,119.7,105.8,66.9,103.5,109.2,97.2,95.4,101.9,88.8,122.5,124.2,90.6,108.8,108.3,89,68.5,67.3,84.1,106,119.9,99.4,111.8,116.3,320,314.2,335.6,292.5,403.4,409.2,298.3,358.2,356.7,293,225.5,221.6,277,349,394.9,327.4,368.3,383.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O76039-1","Cyclin-dependent kinase-like 5 [OS=Homo sapiens]",2,2,4,1,1030,115.5,9.54,11.44,"","","","CDKL5","","","","",1.419,1.427,1.523,1.48,1.477,102.3,102.8,109.8,72.1,106.7,106.4,101.9,102.5,106.9,101.2,107.6,103.1,101.9,111.8,110.1,98.4,72.2,46.4,108.1,97.9,106.9,105.3,111,106.7,227.8,229.2,238.9,226.3,240.4,230.4,227.8,249.8,246,219.9,161.5,103.8,241.6,218.8,239,235.4,248.1,238.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96DY7","mdm2-binding protein [OS=Homo sapiens]",1,1,1,1,904,102.1,7.77,0,"cell cycle OR cell proliferation;other biological processes","other cell component","","MTBP","ENSG00000172167","","","",1.42,1.592,1.355,1.421,1.325,105,117.7,100.2,74,105.1,98,112.6,103.4,95.7,115.9,132.8,111.8,67.3,105.5,98.6,104.5,72.8,63.8,103.4,87.9,119.2,84.6,96.5,123.6,52,47.8,44.2,53.5,61.3,51.6,31.1,48.7,45.6,48.3,33.6,29.5,47.8,40.6,55.1,39.1,44.6,57.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6NTF9","Rhomboid domain-containing protein 2 [OS=Homo sapiens]",7,2,5,2,364,39.2,9.32,13.21,"protein metabolism;other metabolic processes;stress response;signal transduction","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","RHBDD2","ENSG00000005486","","","Ciliary landscape",1.423,1.542,1.48,1.508,1.416,102,110.6,106.1,71.7,108.1,101.5,90.8,99.6,110.2,107.9,101.2,117.6,103.6,101.2,111.2,70,68,108.6,96.1,105.6,109.9,98.6,100.9,99.1,375.4,411.9,455.7,446.4,418.4,486.3,428.3,418.5,459.8,289.4,281.3,449.3,397.5,436.6,454.4,408,417.1,409.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UL26","Ras-related protein Rab-22A [OS=Homo sapiens]",26,4,7,4,194,21.8,8.15,16.74,"cell organization and biogenesis;transport","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","RAB22A","ENSG00000124209","Endocytosis","RAB geranylgeranylation","",1.424,1.566,1.607,1.482,1.42,100.6,110.6,113.4,70.6,104.6,100.3,104.1,104.1,106.3,114.5,96.6,122.3,93.4,117.4,120.6,73.1,83.3,26.7,100.5,108.3,112.7,102.6,103.8,109.5,1020.8,1021.1,1042.5,1122.6,947.3,1199.8,916.3,1151.7,1183,716.9,816.9,261.7,985.5,1062.3,1105.7,1006.2,1018.1,1073.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q5SNV9","Uncharacterized protein C1orf167 [OS=Homo sapiens]",1,1,1,1,1468,162.3,10.7,2.42,"","","","C1orf167","ENSG00000215910","","","",1.425,1.531,1.594,1.559,1.625,97.9,105.2,109.5,68.7,107.1,111.6,102.8,98.5,111.1,110.5,100.5,123.2,82.9,115.1,120.9,77.5,72.2,27.7,112.6,73.8,125.4,117.3,135,93,116.9,112,126.3,125.6,114.3,140.1,94.2,130.8,137.4,88.1,82.1,31.5,128,84,142.5,133.4,153.4,105.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P36404","ADP-ribosylation factor-like protein 2 [OS=Homo sapiens]",5,1,3,1,184,20.9,6.34,7.58,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","ARL2","ENSG00000213465","","Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; Post-chaperonin tubulin folding pathway; RAS processing","Joubert syndrome",1.427,1.621,1.304,1.375,1.42,105.1,119.4,96.1,73.6,101.3,104.6,112,105.4,99.9,96.2,119.8,121,88.5,96.4,99.5,93.7,73.9,69.8,101.6,96.4,114.3,101.7,104.9,105.2,140,131.8,124.9,120.3,149.8,151.3,110.7,120.5,124.4,117.2,92.4,87.3,127.1,120.6,143,127.2,131.2,131.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P07205","Phosphoglycerate kinase 2 [OS=Homo sapiens]",17,7,97,2,417,44.8,8.54,301.71,"other metabolic processes","cytosol;cytoskeleton","kinase activity;other molecular function","PGK2","ENSG00000170950","Glycolysis / Gluconeogenesis; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; HIF-1 signaling pathway","Glycolysis; Gluconeogenesis","Cori cycle; Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis",1.429,1.508,1.312,1.355,1.358,107.7,113.7,98.8,75.4,102.1,102.3,110.6,104.5,112.4,110,117.7,116.8,94.5,114.2,101.5,80.8,77.4,36.1,104.9,99.2,106.7,107.6,99.9,105.1,504,476.3,512.3,501.2,536.4,532.2,430.6,520.3,462.7,368,352.8,164.4,478.1,451.8,486,490.4,455.2,479,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y3E2","BolA-like protein 1 [OS=Homo sapiens]",9,1,1,1,137,14.3,7.96,2.23,"","mitochondrion","","BOLA1","ENSG00000178096","","","",1.435,1.546,1.395,1.512,1.335,104.7,112.8,101.8,73,110.3,97.4,89.6,121.7,107,137.4,93.4,115.2,98.9,104,112.3,74.5,101.4,35.4,112.7,91.3,120.6,99.5,84.5,100.8,48,65.2,57.3,73.6,50,61.7,52.9,55.7,60.2,39.9,54.3,19,60.4,48.9,64.6,53.3,45.2,54,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NX47","E3 ubiquitin-protein ligase MARCH5 [OS=Homo sapiens]",7,2,2,2,278,31.2,8.7,4.06,"protein metabolism;other metabolic processes;other biological processes","other membranes;mitochondrion;ER/Golgi","other molecular function","MARCHF5","ENSG00000198060","","","",1.451,1.341,1.472,1.466,1.374,107.4,99.3,109,74,108.5,101.7,93.8,106.8,106.8,136.5,74.1,98.6,81.2,108.3,133.4,73.6,99.4,72.6,107.9,104.2,113.5,101.1,101.7,86.6,258.7,294.3,294.3,376.1,204.3,271.9,223.8,298.6,367.8,202.8,274,200.1,297.4,287.2,312.8,278.7,280.3,238.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q13501-1","sequestosome-1 [OS=Homo sapiens]",65,15,201,15,440,47.7,5.22,670.03,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","SQSTM1","ENSG00000161011","Mitophagy; Autophagy; Necroptosis; Cellular senescence; Osteoclast differentiation; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Shigellosis; Fluid shear stress and atherosclerosis","Interleukin-1 signaling; Signaling by ALK fusions and activated point mutants; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; PINK1-PRKN Mediated Mitophagy; NRIF signals cell death from the nucleus; Pexophagy","Regulation of toll-like receptor signaling pathway; IL-1 signaling pathway; RANKL/RANK signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Nuclear receptors meta-pathway; NRF2 pathway; Interleukin-1 induced activation of NF-kB; Clear cell renal cell carcinoma pathways; CAMKK2 pathway; 7q11.23 copy number variation syndrome; Senescence and autophagy in cancer",1.455,1.453,1.328,1.343,1.204,112.2,112,102.4,77.1,103.5,92.8,110.5,117.5,109,110.3,108.9,114.8,101.4,100.3,100.8,68.2,75.9,104.1,101.9,103.5,98.8,91.4,94.4,88.2,12447.4,13243.3,12281.4,12428.9,12266.5,12939.5,11428.1,11300.9,11361,7688.8,8556.3,11732.8,11487,11657.9,11127,10303,10636.1,9932.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8TDI8","Transmembrane channel-like protein 1 [OS=Homo sapiens]",1,1,2,1,760,87.7,6.52,3.9,"transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","transporter activity","TMC1","ENSG00000165091","","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea","",1.458,1.408,1.467,1.297,1.472,108,104.3,108.7,74,96.1,109,120.1,99.3,114.1,110.2,121.5,89.6,78.3,114.8,124.2,81.5,78.2,18.9,92.8,101.5,120.6,99.5,119.6,115.2,463.9,383.6,440.6,425.4,469.3,346,302.2,443.4,479.6,314.8,302.2,73.1,358.2,391.9,465.8,384.2,461.7,444.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8NBB4","Zinc finger and SCAN domain-containing protein 1 [OS=Homo sapiens]",2,1,1,1,408,45.3,8.54,0,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZSCAN1","ENSG00000152467","","","",1.458,1.435,1.254,1.256,1.434,111.6,109.9,96,76.6,96.2,109.8,115,100.6,117.6,113.2,104.5,118.5,80.6,98.9,125.4,78.9,82.4,25.7,99.1,109.8,97.3,113.1,122.4,96.9,135.2,118.3,138.3,133.1,122.9,139.4,94.8,116.3,147.5,92.7,96.9,30.2,116.5,129.1,114.4,133,143.9,114,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q14119","Vascular endothelial zinc finger 1 [OS=Homo sapiens]",5,2,2,1,521,56.9,9.52,7.75,"stress response;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","VEZF1","ENSG00000136451","","","",1.458,1.391,1.555,1.222,1.338,109.9,104.8,117.2,75.3,92.1,100.8,85.9,108.6,109.2,127.6,102.6,103.6,80.1,115.8,139.1,74.5,82.2,35.3,135.6,74.7,91,136.3,99.7,98.1,192.2,243,244.2,285.5,229.4,231.7,179.1,259.2,311.2,166.6,183.8,79,303.4,167.1,203.6,305,223,219.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8N3C7-1","CAP-Gly domain-containing linker protein 4 [OS=Homo sapiens]",1,1,6,1,705,76.3,8.7,9.49,"cell organization and biogenesis","cytoskeleton;nucleus;other cell component","cytoskeletal activity","CLIP4","ENSG00000115295","","","",1.459,1.43,1.425,1.459,1.442,106.5,104.4,104.1,73,106.6,105.3,103.8,110,111.5,107.9,64.8,109.2,90.7,107.5,112.6,75.4,105.3,64.1,104.6,110.1,111.3,109.2,108.8,93,1015.3,1075.9,1090.6,1054.7,633.4,1068.1,887.3,1051.3,1100.7,737.6,1029.8,626.6,1022.9,1076.5,1088.6,1067.4,1063.6,909.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UKU7","Isobutyryl-CoA dehydrogenase, mitochondrial [OS=Homo sapiens]",18,6,10,6,415,45,7.85,31.41,"other metabolic processes","mitochondrion","other molecular function","ACAD8","ENSG00000151498","Valine, leucine and isoleucine degradation; Metabolic pathways","Branched-chain amino acid catabolism","",1.459,1.391,1.458,1.363,1.441,107.9,102.9,107.8,74,100.8,106.6,106.9,108.7,109.9,103.6,93.3,117,97.3,108.6,114,74.5,77.7,63.4,101.5,95.6,111.3,107.3,107.6,101.9,1283.3,1304.3,1318.7,1243.5,1119.7,1404.5,1167.3,1302.8,1368.6,893.7,932.3,760.5,1217.8,1147,1335.4,1288,1291.3,1222.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P51955","Serine/threonine-protein kinase Nek2 [OS=Homo sapiens]",2,1,2,1,445,51.7,8.9,6.24,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","NEK2","ENSG00000117650","","Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; APC-Cdc20 mediated degradation of Nek2A","Ciliopathies",1.46,1.239,1.445,1.489,1.551,107,90.8,105.9,73.3,109.2,113.7,95.3,107.7,104.4,88.4,88.6,91.7,105,103.3,85.2,70.1,71.5,135.5,102.8,117.3,106.5,117.1,98.6,110.9,130.9,147.9,143.4,121.5,121.7,125.9,144.2,141.9,117.1,96.2,98.3,186.1,141.2,161.1,146.3,160.8,135.4,152.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BWF3-1","RNA-binding protein 4 [OS=Homo sapiens]",46,15,44,15,364,40.3,7.08,116.4,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RBM14; RBM4","ENSCATG00000036313; ENSG00000173933; ENSGGOG00000014455; ENSMFAG00000052468; ENSMLEG00000024601; ENSMMUG00000020363; ENSMNEG00000014872; ENSNLEG00000035021; ENSPPAG00000033403; ENSPTRG00000003934; ENSRBIG00000043267; ENSRROG00000044302","","Circadian Clock","",1.468,1.437,1.435,1.379,1.334,109.4,107,106.9,74.5,102.7,99.4,110.8,108,109.4,111.2,105.1,107.1,103.8,106.9,107.1,74.5,74.6,71.6,102.6,102.8,104,102.3,99.1,99.4,6454.7,6291,6374.3,6477.2,6121.2,6237.4,6046.5,6231.1,6237.7,4341.3,4349.3,4171,5975.5,5987.2,6057.1,5957.9,5772.5,5793,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NZC3","glycerophosphodiester phosphodiesterase 1 [OS=Homo sapiens]",12,4,10,4,331,37.7,6.71,18.63,"other metabolic processes","plasma membrane;other membranes","other molecular function","GDE1","ENSG00000006007","","Glycerophospholipid catabolism","",1.47,1.446,1.499,1.417,1.402,107.1,105.3,109.2,72.9,103.3,102.2,104.4,110.3,111,108.5,84.2,114.3,97.2,112.5,116.7,75,86.4,46.7,106.3,102.5,115.4,105.6,105.2,97.7,1840.4,1944.7,1957.3,1912.7,1485.2,2015.6,1713.9,1983.1,2058.4,1323.1,1523.7,823.5,1875.1,1808,2035.3,1861.4,1855.3,1722.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P08922","Proto-oncogene tyrosine-protein kinase ROS [OS=Homo sapiens]",0,1,1,1,2347,263.7,6.11,1.93,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","kinase activity;other molecular function","ROS1","ENSG00000047936","","","Spinal cord injury; NAD metabolism, sirtuins and aging; FGF23 signaling in hypophosphatemic rickets and related disorders",1.472,1.508,1.285,1.237,1.463,110.9,113.6,96.8,75.3,93.2,110.2,101,107.6,114,106.9,110.2,126.5,84.6,93.9,107.3,97.5,73.1,45.4,84,90.4,126.8,106.9,118,106,197.3,210.2,222.9,209,215.4,247.2,165.3,183.5,209.7,190.5,142.8,88.7,164.1,176.7,247.7,208.9,230.6,207.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y2Z9-1","Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial [OS=Homo sapiens]",6,3,4,3,468,50.8,7.3,4.76,"other metabolic processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","COQ6","ENSG00000119723","Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways; Biosynthesis of cofactors","Ubiquinol biosynthesis","Nephrotic syndrome",1.475,1.464,1.447,1.415,1.404,107.9,107.1,105.8,73.1,103.5,102.7,114,99.2,109.5,89.8,116.6,108.7,100.2,107.5,110.9,89.3,74.3,52.9,95,105,108.9,100.9,104.2,113,429,373.2,412.1,338.1,438.8,409,377.3,404.4,417.3,336.2,279.4,198.9,357.5,395.3,410,379.7,392.3,425.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q07820","Induced myeloid leukemia cell differentiation protein Mcl-1 [OS=Homo sapiens]",39,8,20,8,350,37.3,5.66,62.77,"stress response;transport;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","transporter activity;other molecular function","MCL1","ENSG00000143384","PI3K-Akt signaling pathway; Apoptosis; JAK-STAT signaling pathway; MicroRNAs in cancer","Interleukin-4 and Interleukin-13 signaling","Apoptosis; Photodynamic therapy-induced HIF-1 survival signaling; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; PI3K-Akt signaling pathway; MicroRNA network associated with chronic lymphocytic leukemia; Host-pathogen interaction of human coronaviruses - apoptosis; Malignant pleural mesothelioma",1.475,1.521,1.322,1.185,1.068,116.9,120.6,104.7,79.2,93.9,84.6,114.8,115.1,113.4,118.6,118.4,116.8,101.3,105.7,102.9,76.1,77.8,112,92.3,93,89.4,87.7,81.4,83.2,1573.8,1578.3,1554.9,1625.5,1623.2,1601.6,1389.1,1448.9,1410.4,1042.7,1067,1535,1264.7,1274.7,1225.2,1202.4,1115.4,1139.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8NCD3-1","Holliday junction recognition protein [OS=Homo sapiens]",1,1,1,1,748,83.5,9.31,0,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","HJURP","ENSG00000123485","","Deposition of new CENPA-containing nucleosomes at the centromere","",1.478,1.285,1.235,1.322,1.255,117.1,101.8,97.8,79.2,104.7,99.4,124.1,116.5,126.3,78.4,111.8,107.8,103.6,111.1,85.4,89.4,83.9,27.6,90.9,123.6,110.9,108.1,95.3,105.3,102.7,96.5,104.6,64.9,92.6,89.3,85.8,92,70.7,74,69.5,22.9,75.3,102.4,91.8,89.5,79,87.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q86YA3-1","Protein ZGRF1 [OS=Homo sapiens]",1,1,1,1,2104,236.5,6.16,0,"DNA metabolism;other metabolic processes","other membranes;other cell component","nucleic acid binding activity;other molecular function","ZGRF1","ENSG00000138658","","","",1.482,1.352,1.348,1.383,1.435,111.1,101.4,101.1,75,103.7,107.6,109,101.9,125.1,110.3,98,99.5,95.6,100.8,99.2,73.6,96.1,69.7,114.8,93.7,101.8,93.1,105.6,112.4,63.1,59,72.4,63.8,56.7,57.6,55.4,58.4,57.4,42.6,55.7,40.3,66.4,54.2,58.9,53.9,61.1,65.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P02792","Ferritin light chain [OS=Homo sapiens]",62,11,90,11,175,20,5.78,266.59,"transport;other biological processes","non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component","other molecular function","FTL","ENSG00000087086","Ferroptosis; Necroptosis; Mineral absorption","Neutrophil degranulation; Scavenging by Class A Receptors; Golgi Associated Vesicle Biogenesis; Iron uptake and transport","Nuclear receptors meta-pathway; NRF2 pathway; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway",1.483,1.156,1.171,1.111,1.174,125.4,97.8,99.1,84.6,94,99.2,126.1,132.5,117.2,96.8,98.3,107.2,102.3,87.1,99.6,70.3,85,96.4,103.7,94.5,81.3,99.8,108.2,93.8,19099.3,20082.7,17752.8,14664.5,14896.5,16241,15500.3,13193.3,15089.7,10647.9,12880.8,14601.4,15717.7,14315.5,12322.2,15117.7,16387.4,14215.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8NFH8-1","RalBP1-associated Eps domain-containing protein 2 [OS=Homo sapiens]",3,1,1,1,660,71.5,7.65,0,"cell organization and biogenesis;transport;signal transduction","cytosol","other molecular function","REPS2","ENSG00000169891","","Cargo recognition for clathrin-mediated endocytosis","EGF/EGFR signaling pathway",1.491,1.714,0.92,1.881,1.403,106.4,122.3,65.7,71.3,134.2,100.1,95.4,149.8,106.5,122.5,80.7,122.7,61.7,65.7,105.1,71.4,121.6,23.2,146.1,134.4,114.5,101.6,100.2,76.8,12.3,19.4,13.8,15.8,10.4,15.9,8,8.5,13.6,9.2,15.7,3,18.9,17.4,14.8,13.1,13,9.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O95235","kinesin-like protein KIF20A [OS=Homo sapiens]",19,14,24,14,890,100.2,6.92,75.44,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","KIF20A","ENSG00000112984","","COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Mitotic Telophase/Cytokinesis","",1.498,1.389,1.423,1.401,1.304,112.1,104,106.5,74.9,104.9,97.7,111.7,112,106.5,98.7,109.2,103.6,107.5,105.2,106.1,74.5,73.1,81.7,104.4,104.1,106.4,96.2,97.2,102,1622.5,1628,1547.4,1434.1,1586.2,1504.6,1561.9,1528.9,1541,1083.2,1061.5,1186.7,1517,1511.9,1546.2,1397.1,1412.9,1482.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H2K2","Tankyrase-2 [OS=Homo sapiens]",2,2,3,2,1166,126.8,7.2,2.08,"cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","TNKS2","ENSG00000107854","","Degradation of AXIN; Ub-specific processing proteases; Regulation of PTEN stability and activity; XAV939 stabilizes AXIN","NAD+ biosynthetic pathways",1.5,1.667,1.601,1.453,1.75,100.3,111.5,107.1,66.9,97.2,117.1,101.8,101.3,117.7,113.1,122.5,106,85.7,112.1,108.6,91,67.8,17.2,98.6,80.2,119.3,112.8,118.7,125.8,109.5,109,126.6,121.7,131.8,114.1,92.2,120.6,116.9,97.9,73,18.5,106.1,86.2,128.4,121.4,127.8,135.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O94874-3","Isoform 3 of E3 UFM1-protein ligase 1 [OS=Homo sapiens]",52,23,71,1,509,57.5,6.3,196.23,"","","","UFL1","","","","",1.504,1.652,1.299,1.419,1.625,106.2,116.6,91.7,70.6,100.2,114.7,127.6,110.8,108.1,88.2,121.7,146.1,95.7,105.1,81.9,108.4,73.6,24.2,75.6,104.5,119.3,64.5,119.6,125.2,60.4,52.4,51.2,41.7,57.6,69.2,45.3,49.7,38.8,51.3,34.9,11.4,35.8,49.5,56.5,30.5,56.6,59.2,"High","High","High","High","High","High","High","High","High","High","High","Not Found","High","High","High","High","High","High"]
["Q9H5I1","Histone-lysine N-methyltransferase SUV39H2 [OS=Homo sapiens]",2,1,1,1,410,46.7,8.19,2.19,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SUV39H2","ENSG00000152455","Lysine degradation; Metabolic pathways","PKMTs methylate histone lysines","Histone modifications",1.506,1.139,1.478,1.256,1.416,115.9,87.7,113.8,77,96.7,109,112.8,91.6,118.6,70.7,85.4,125.1,105.2,119.6,110.8,74.9,89.2,56.1,87,94.1,111.6,101.1,139.9,106.1,42.2,34.2,44.3,26.4,31.9,46.8,39.3,44.7,41.4,28,33.4,21,32.5,35.2,41.7,37.8,52.3,39.7,"High","High","High","High","High","High","High","High","High","High","High","Not Found","High","High","High","High","High","High"]
["P18847","Cyclic AMP-dependent transcription factor ATF-3 [OS=Homo sapiens]",6,1,1,1,181,20.6,8.54,2.63,"other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ATF3","ENSG00000162772","","Response of EIF2AK4 (GCN2) to amino acid deficiency; Response of EIF2AK1 (HRI) to heme deficiency; ATF4 activates genes in response to endoplasmic reticulum  stress","Myometrial relaxation and contraction pathways; Photodynamic therapy-induced unfolded protein response; TGF-beta signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; IL-18 signaling pathway; CCL18 signaling pathway; Hypertrophy model",1.518,1.322,1.572,1.517,1.643,106.3,92.5,110.1,70,106.2,115,104.3,104.4,118.5,90.9,90.9,97.9,108.1,118.9,86.4,59.1,68.7,79,115.8,90.7,104.3,112.9,136.7,112.8,42,42,47.7,36.6,36.6,39.4,43.5,47.8,34.8,23.8,27.7,31.8,46.6,36.5,42,45.4,55,45.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BU64-1","centromere protein O [OS=Homo sapiens]",17,3,3,3,300,33.8,7.71,12.57,"cell organization and biogenesis","cytosol;nucleus;other cell component","","CENPO","ENSG00000138092","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Deposition of new CENPA-containing nucleosomes at the centromere","",1.523,1.52,1.638,1.403,1.452,107.1,106.8,115.2,70.3,98.6,102.1,109.4,118.4,96.3,100,111.1,109.2,101,121,117.7,81.6,71.8,43.9,93.4,100.8,110.7,101,104.3,108.5,176.2,190.6,155.1,160.9,178.9,175.8,162.5,194.8,189.5,131.3,115.7,70.6,150.4,162.2,178.1,162.7,168,174.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q7Z2W4-3","Isoform 3 of Zinc finger CCCH-type antiviral protein 1 [OS=Homo sapiens]",40,22,69,1,624,67.5,8.72,230.31,"","","","ZC3HAV1","","","","",1.533,1.377,1.415,1.376,1.261,115.5,103.8,106.6,75.4,103.7,95,123.3,117.5,115.9,118.7,98.2,105.6,96.6,108.5,113.4,76.7,80.7,33.7,99.2,105.5,107.2,107.8,94.9,96.6,535.8,510.4,503.6,515.5,426.5,458.6,419.6,471.2,492.4,333,350.6,146.6,430.9,458.3,465.8,468.1,412.3,419.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P58005-1","sestrin-3 [OS=Homo sapiens]",5,2,3,2,492,57.3,6.25,5.58,"stress response;signal transduction;other biological processes","nucleus;other cell component","other molecular function","SESN3","ENSG00000149212","p53 signaling pathway; Longevity regulating pathway","TP53 Regulates Metabolic Genes","Angiopoietin-like protein 8 regulatory pathway; miRNA regulation of p53 pathway in prostate cancer",1.534,1.558,1.338,1.296,1.264,115.2,117,100.5,75.1,97.3,94.9,110.4,115,112.4,114.2,132.6,105.9,98.1,100.8,94.6,68.1,73.3,115.2,85.3,95,100.1,92.7,91.4,95.1,157.9,164.5,160.7,163.2,189.6,151.4,140.3,144.1,135.3,97.3,104.8,164.7,122,135.8,143.2,132.5,130.8,135.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6ZN30","Zinc finger protein basonuclin-2 [OS=Homo sapiens]",1,1,2,1,1099,122.3,6.52,2.06,"developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","BNC2","ENSG00000173068","","","",1.535,1.504,1.297,1.43,1.266,114.7,112.4,96.9,74.7,106.8,94.6,119.7,113,99,110.7,112.5,100.9,92.8,95.5,103.8,73.6,69.6,113.8,102.8,108.8,105.2,93.2,91.5,93.5,152.8,144.2,126.3,141.3,143.6,128.7,118.4,121.8,132.5,93.9,88.8,145.2,131.2,138.9,134.2,118.9,116.8,119.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P14209","CD99 antigen [OS=Homo sapiens]",5,1,3,1,185,18.8,4.75,8.02,"cell adhesion;other biological processes","plasma membrane;other membranes;other cell component","","CD99","ENSG00000002586","Cell adhesion molecules; Leukocyte transendothelial migration","Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall","",1.539,1.476,1.351,1.288,1.351,115.4,110.6,101.3,75,96.5,101.3,108.9,122.7,101.4,104.4,77.3,125.8,89.7,95.6,106.4,70.7,122.1,67.1,91.1,114.8,89,95.6,123,94.6,396.6,447.1,369.3,380.3,281.5,458.4,326.9,348.2,387.8,257.7,445,244.6,331.8,418.2,324.4,348.2,448.3,344.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BY14-1","Testis-expressed protein 101 [OS=Homo sapiens]",10,1,2,1,249,26.6,4.94,2.5,"other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","","TEX101","ENSG00000131126","","Post-translational modification: synthesis of GPI-anchored proteins","",1.544,2.509,1.831,1.636,2.391,84.9,138,100.7,55,90,131.5,85.2,78.5,123.7,152.3,138.4,111.5,101,97,114.1,55.2,84.1,54.3,83,90.2,101.1,59.1,139.6,131.9,14.1,13,20.5,25.2,22.9,18.5,16.7,16.1,18.9,9.1,13.9,9,13.7,14.9,16.7,9.8,23.1,21.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96L58","Beta-1,3-galactosyltransferase 6 [OS=Homo sapiens]",4,1,1,1,329,37.1,9.66,3.44,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","B3GALT6","ENSG00000176022","Glycosaminoglycan biosynthesis; Glycosaminoglycan biosynthesis; Metabolic pathways","A tetrasaccharide linker sequence is required for GAG synthesis; Defective B3GALT6 causes EDSP2 and SEMDJL1","Proteoglycan biosynthesis",1.547,1.553,1.187,1.066,1.099,124.6,125,95.6,80.5,85.8,88.5,123.4,140.5,91.6,106.4,127.6,123.8,89.7,151.8,94.6,97.7,79.7,9.5,85,83.5,107.4,125.1,87.6,75.2,16,18.2,11.9,13.8,16.5,16,11.6,19.7,12.3,12.7,10.3,1.2,11,10.8,13.9,16.2,11.4,9.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P50225","Sulfotransferase 1A1 [OS=Homo sapiens]",11,3,9,1,295,34.1,6.62,21.46,"other metabolic processes","cytosol;other cell component","other molecular function","SULT1A1","ENSG00000196502","Chemical carcinogenesis","Cytosolic sulfonation of small molecules","Constitutive androstane receptor pathway; Nuclear receptors meta-pathway; Melatonin metabolism and effects; Tamoxifen metabolism; Sulfation biotransformation reaction; Arylamine metabolism; Estrogen metabolism; Metapathway biotransformation Phase I and II; Vitamin A and carotenoid metabolism",1.55,1.694,1.737,1.511,1.645,101.8,111.3,114.1,65.7,99.2,108,100.1,98.3,112.9,109.4,129,108.6,81.5,112.2,113.5,82.4,64.6,45.5,97.6,92.4,127.1,105.8,106.3,112.8,119.1,116.9,134.3,130.2,153.5,129.3,97,133.6,135.1,98.1,76.9,54.2,116.1,109.9,151.3,126,126.5,134.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UI32","Glutaminase liver isoform, mitochondrial [OS=Homo sapiens]",1,1,2,1,602,66.3,7.3,4.69,"other metabolic processes;other biological processes","mitochondrion","other molecular function","GLS2","ENSG00000135423","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; D-Amino acid metabolism; Metabolic pathways; Glutamatergic synapse; GABAergic synapse; Proximal tubule bicarbonate reclamation; MicroRNAs in cancer; Central carbon metabolism in cancer","TP53 Regulates Metabolic Genes; Glutamate and glutamine metabolism; Glutamate Neurotransmitter Release Cycle","p53 transcriptional gene network; Neuroinflammation and glutamatergic signaling",1.554,1.643,1.559,1.391,1.516,107.6,113.8,108,69.3,96.3,105,114.3,104.2,107.3,104.3,113.5,123.4,110.2,104.8,107.7,83.7,69.1,43.7,93.8,96.1,107.2,107.7,104.4,104.7,350.6,319.5,329.1,320,348,378.5,338,321.5,330.3,256.7,211.8,134,287.6,294.7,328.9,330.2,320.2,321.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P15104","Glutamine synthetase [OS=Homo sapiens]",21,10,17,10,373,42,6.89,44.96,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cell component","other molecular function","GLUL","ENSG00000135821","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Glyoxylate and dicarboxylate metabolism; Nitrogen metabolism; Metabolic pathways; Biosynthesis of amino acids; Necroptosis; Glutamatergic synapse; GABAergic synapse","Glutamate and glutamine metabolism; Astrocytic Glutamate-Glutamine Uptake And Metabolism","TNF-alpha signaling pathway; Amino acid metabolism",1.556,1.493,1.531,1.491,1.444,109.7,105.2,107.9,70.5,105.1,101.7,109.4,106.2,106.1,100.6,106.3,101.9,104.4,100.4,105.4,68.2,64.6,124.9,101.7,99.2,105.2,98.6,98.5,98.4,2467,2395.4,2392.8,2270.2,2398.9,2298,2356.2,2264.2,2377.9,1539.2,1457.8,2817.6,2294.6,2237.2,2373.9,2223.3,2222.1,2220.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q15323","Keratin, type I cuticular Ha1 [OS=Homo sapiens]",4,2,4,1,416,47.2,4.88,8.47,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","cytoskeletal activity","KRT31","ENSG00000094796; ENSG00000262993","Estrogen signaling pathway; Staphylococcus aureus infection","Formation of the cornified envelope","IL-18 signaling pathway",1.557,0.836,1.228,0.929,1.861,126.1,67.7,99.4,81,75.2,150.6,113.1,120.4,44.1,60.7,76.2,59.1,121.3,89.2,87.8,300.9,47.8,72.6,76.7,56.8,67.5,212.7,58.1,135.1,62.8,66.9,24.5,33.7,42.4,32.8,67.4,49.6,48.8,167.2,26.6,40.4,42.6,31.6,37.5,118.2,32.3,75.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8IW19","Aprataxin and PNK-like factor [OS=Homo sapiens]",5,2,2,2,511,56.9,5.08,6.3,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","APLF","ENSG00000169621","","","",1.558,1.798,1.755,1.642,1.485,101.2,116.8,114,65,106.7,96.4,110,84.1,101.5,133.8,94.4,117.2,114.3,109.5,118.9,61.7,90.2,65.2,108.3,107,95.8,94.2,97.2,96.7,82.8,63.3,76.4,100.7,71.1,88.2,86.1,82.4,89.5,46.5,67.9,49,81.5,80.5,72.1,70.9,73.1,72.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P18627","Lymphocyte activation gene 3 protein [OS=Homo sapiens]",3,1,1,1,525,57.4,7.97,0,"signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","LAG3","ENSG00000089692","","MHC class II antigen presentation","SARS-CoV-2 innate immunity evasion and cell-specific immune response",1.56,1.725,1.738,1.595,1.525,102.4,113.2,114,65.6,104.7,100.1,94.3,105.6,125.5,116.8,58.5,121.2,83.6,117.6,148.8,50,94.3,67.7,96,108.4,108,124.2,103.2,76.3,96.5,108.1,128.5,119.5,59.9,124.1,85.6,120.4,152.3,51.2,96.5,69.3,98.3,110.9,110.5,127.1,105.6,78,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q12834","cell division cycle protein 20 homolog [OS=Homo sapiens]",7,3,3,3,499,54.7,9.23,6.32,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","CDC20","ENSG00000117399","Cell cycle; Oocyte meiosis; Ubiquitin mediated proteolysis; Human T-cell leukemia virus 1 infection; Viral carcinogenesis","Antigen processing: Ubiquitination & Proteasome degradation; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Ub-specific processing proteases; RHO GTPases Activate Formins; Resolution of Sister Chromatid Cohesion; APC/C:Cdc20 mediated degradation of Cyclin B; Phosphorylation of Emi1; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; APC-Cdc20 mediated degradation of Nek2A; Inactivation of APC/C via direct inhibition of the APC/C complex; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase","Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition",1.561,1.53,1.578,1.633,1.6,105.2,103.1,106.3,67.4,110.1,107.8,102.4,112.5,101.5,99.6,116.4,100.4,106.3,103,103.5,65.6,58.6,96.9,103.1,107.1,110,105,102.5,105.5,452.7,497.2,448.6,440.2,514.4,443.6,469.6,455.1,457.4,289.9,258.8,428,455.5,473.4,486.2,463.8,453,466.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96EY9","probable inactive tRNA-specific adenosine deaminase-like protein 3 [OS=Homo sapiens]",11,3,4,3,351,38,7.88,6.7,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","ADAT3","","","tRNA modification in the nucleus and cytosol","",1.575,1.432,1.564,1.631,1.499,108.6,98.8,107.8,69,112.5,103.4,106.7,95.3,103.5,94.1,94.5,93.4,102.7,92.8,103.3,65.7,63.6,162.5,109.8,105.1,107.1,98.5,97,104.3,399.5,356.9,387.4,352.3,353.7,349.6,384.7,347.6,386.8,246,237.9,608.4,411.2,393.5,401.2,368.7,363.2,390.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q92522","Histone H1x [OS=Homo sapiens]",54,15,108,15,213,22.5,10.76,339.77,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity","H1-10","ENSG00000184897","","","",1.576,1.318,1.406,1.41,1.314,117.9,98.5,105.1,74.8,105.4,98.3,106.3,116.9,117.1,111.1,97.8,91.9,108.8,104.3,95.4,68.2,74.2,97.9,104.6,107.9,102.4,102.4,95.4,97.5,18396.2,20226.4,20256.4,19221.9,16911.1,15894.9,18827.5,18044.3,16499,11792.9,12834.8,16936.8,18093.2,18656.4,17707.5,17705.6,16497.1,16865.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q08AF3-1","schlafen family member 5 [OS=Homo sapiens]",7,5,11,4,891,101,8.22,29.52,"other biological processes","nucleus","other molecular function","SLFN5","ENSG00000166750","","","",1.596,1.54,1.493,1.345,1.321,115.5,111.4,108,72.3,97.3,95.6,111.9,122.1,114.5,108.2,110.5,121.5,101.5,107.1,108.4,70.6,71.8,75.7,96.4,100.3,96.5,95.3,92.9,94.8,589.6,643.7,603.6,570.1,582.3,640.3,535,564.5,571.4,371.9,378.2,399.2,508,528.7,508.7,502.5,489.6,499.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BV10","Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase [OS=Homo sapiens]",3,1,1,1,488,54.6,9.58,0,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","ALG12","ENSG00000182858","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG12 causes CDG-1g","",1.609,1.343,1.81,1.852,1.582,105,87.6,118.1,65.2,120.8,103.2,89.4,118.8,106.7,89,80.2,123.3,120,89.9,122.9,85.5,66.3,48.2,84.1,122.8,128.2,85,134.7,104.9,12.1,16.1,14.5,12.1,10.9,16.7,16.3,12.2,16.7,11.6,9,6.5,11.4,16.6,17.4,11.5,18.3,14.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UI43","rRNA methyltransferase 2, mitochondrial [OS=Homo sapiens]",4,1,1,1,246,27.4,9.5,0,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus","other molecular function","MRM2","ENSG00000122687","","rRNA modification in the mitochondrion","",1.611,1.608,1.618,1.304,1.665,109.8,109.5,110.3,68.1,88.9,113.4,109.5,96.9,118.4,109.2,114.5,102.4,94.1,114.8,110,108.4,67.9,40,84,88.6,109.9,113.2,105,113.1,52.6,46.6,56.9,52.5,55.1,49.2,45.2,55.2,52.9,52.1,32.7,19.2,40.4,42.6,52.8,54.4,50.5,54.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96CX6","Leucine-rich repeat-containing protein 58 [OS=Homo sapiens]",4,1,1,1,371,40.6,6.84,4.73,"","","","LRRC58","ENSG00000163428","","","",1.635,1.694,1.519,1.418,1.256,115.1,119.2,106.9,70.4,99.9,88.4,115.6,87.9,117.5,119.7,166.1,88.8,107.3,108.7,84.5,70.7,84.6,68,94.1,100.2,110.4,88.8,74.8,112.5,29.6,22.5,30.1,30.6,42.5,22.7,27.5,27.8,21.6,18.1,21.7,17.4,24.1,25.7,28.3,22.7,19.1,28.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P22413","Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [OS=Homo sapiens]",4,2,2,2,925,104.9,7.14,6.48,"other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","ENPP1","ENSG00000197594","Purine metabolism; Pyrimidine metabolism; Starch and sucrose metabolism; Riboflavin metabolism; Nicotinate and nicotinamide metabolism; Pantothenate and CoA biosynthesis; Metabolic pathways","Vitamin B5 (pantothenate) metabolism; Vitamin B2 (riboflavin) metabolism","Pyrimidine metabolism; Endochondral ossification; FGF23 signaling in hypophosphatemic rickets and related disorders; Endochondral ossification with skeletal dysplasias; Insulin signaling",1.644,1.552,1.499,1.465,1.313,116.4,109.9,106.2,70.8,103.8,93,117.6,109.9,120.2,111,78.1,124.1,102,107.3,111.9,71.6,86.9,64.8,91.9,104.9,110.1,87.9,94,105.6,149.5,139.7,152.8,141.1,99.3,157.7,129.7,136.3,142.3,90.9,110.5,82.4,116.8,133.3,139.9,111.7,119.5,134.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8IV08","Phospholipase D3 [OS=Homo sapiens]",9,4,10,4,490,54.7,6.47,22.53,"DNA metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","PLD3","ENSG00000105223","Glycerophospholipid metabolism; Ether lipid metabolism; Metabolic pathways","Synthesis of PG; Role of phospholipids in phagocytosis","",1.646,1.7,1.569,1.372,1.524,112.1,115.7,106.9,68.1,93.4,103.8,109.1,113,113.3,104.2,116.7,126.7,98.6,109,107.8,81.5,68.7,52.2,89.6,94.2,104.8,99.9,104.7,105.9,821.1,850.4,852.9,783.9,878.1,953,742.2,820.3,810.9,613.5,516.7,392.9,674.4,708.7,788.8,752,787.5,796.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P02671-1","Fibrinogen alpha chain [OS=Homo sapiens]",1,1,1,1,866,94.9,6.01,2.72,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGA","ENSG00000171560","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Coronavirus disease","ER-Phagosome pathway; Signaling by BRAF and RAF1 fusions; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Amyloid fiber formation; Integrin cell surface interactions; Platelet degranulation ; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Common Pathway of Fibrin Clot Formation; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway",1.646,1.403,1.367,1.142,1.328,125.2,106.8,104,76.1,86.9,101,125,95.5,114.4,64.7,97.5,103.6,95,100.7,63.8,96,69.5,63.9,79.3,65.2,315.2,63,95.4,92.3,198.1,151.3,181.2,102.5,154.5,164.2,150.5,159.6,101.1,152.1,110.1,101.3,125.7,103.3,499.5,99.8,151.1,146.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P31152","mitogen-activated protein kinase 4 [OS=Homo sapiens]",4,2,7,1,587,65.9,5.45,9.44,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction","cytosol;nucleus;other cell component","kinase activity;other molecular function","MAPK4","ENSG00000141639","IL-17 signaling pathway","MAPK6/MAPK4 signaling","MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; B cell receptor signaling pathway; S1P receptor signal transduction; TGF-beta signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; Splicing factor NOVA regulated synaptic proteins; EGF/EGFR signaling pathway; Osteoblast differentiation and related diseases; Insulin signaling; Regulation of actin cytoskeleton",1.647,1.121,1.117,1.003,1.762,129.2,87.9,87.6,78.4,78.6,138.2,101,145.7,120.1,81.7,74.1,168.4,70.1,81.4,92.1,72.9,88.8,14.7,110,64.6,73.1,128.5,223.5,89,1726,2489.9,2052.5,1396.4,1265.6,2876.9,1197.2,1391.6,1573.6,1246,1518,251.5,1879.3,1104.2,1249.4,2195.6,3818.9,1521.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8TAQ9-2","Isoform 2 of SUN domain-containing protein 3 [OS=Homo sapiens]",7,1,1,1,269,30.7,6.9,0,"","","","SUN3","","","","",1.666,1.529,1.674,2.025,1.682,104.4,95.8,104.9,62.7,126.9,105.4,103.6,97.1,118.4,128.6,82.8,95.1,90.5,104.1,109.7,62.2,84.5,17.1,113.2,125.9,126.8,104.6,136.6,99.2,58.6,55,67.1,72.8,46.9,53.8,51.2,58.9,62.1,35.2,47.8,9.7,64.1,71.3,71.8,59.2,77.3,56.2,"High","High","High","High","High","High","High","High","High","High","High","Not Found","High","High","High","High","High","High"]
["Q58FF8","Putative heat shock protein HSP 90-beta 2 [OS=Homo sapiens]",28,15,244,2,381,44.3,4.84,677.48,"stress response;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","HSP90AB2P","","","","",1.683,0.81,1.778,1.83,1.496,117.5,56.5,124.1,69.8,127.7,104.4,114.4,108.2,107.4,131.5,52.1,47.4,92.4,114.3,123.7,64.3,187.3,13.2,130,117.6,104.3,103.5,92.3,96.2,6735.9,6370.4,6324.9,7743.9,3065.5,2789.1,5438.1,6729.6,7280.2,3784.1,11024.3,774.2,7655.5,6923.4,6140.7,6090.7,5435.7,5661.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q16720-1","Plasma membrane calcium-transporting ATPase 3 [OS=Homo sapiens]",9,10,18,1,1220,134.1,5.62,61.63,"transport;other biological processes","plasma membrane;other membranes;other cell component","transporter activity;other molecular function","ATP2B3","ENSG00000067842; ENSGGOG00000007217; ENSPPAG00000028306; ENSPTRG00000022399","Calcium signaling pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Adrenergic signaling in cardiomyocytes; Aldosterone synthesis and secretion; Endocrine and other factor-regulated calcium reabsorption; Salivary secretion; Pancreatic secretion; Mineral absorption","Ion homeostasis; Ion transport by P-type ATPases; Reduction of cytosolic Ca++ levels","Vitamin D-sensitive calcium signaling in depression; Calcium regulation in cardiac cells; Calcium regulation in cardiac cells",1.686,1.372,1.735,1.83,1.534,110.5,89.9,113.7,65.5,119.9,100.5,70.3,152.1,105.9,76.1,116.2,86.2,147.6,109,99.8,53.5,81.5,62.8,131.9,101.5,115,113.7,80.3,96.4,30.8,66.6,46.4,33.3,50.9,37.8,64.7,47.7,43.7,23.4,35.7,27.5,57.8,44.4,50.4,49.8,35.2,42.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O00555-1","Voltage-dependent P/Q-type calcium channel subunit alpha-1A [OS=Homo sapiens]",1,1,2,1,2505,282.2,8.84,2.07,"","","","","","","","",1.689,1.644,1.745,1.576,1.993,105,102.2,108.5,62.2,98,124,93.6,112.5,119.9,102.4,109.5,121,87.1,116.2,118.1,66.6,71,27.5,108.1,77.6,105,132.8,132.8,98.2,753.3,905.6,965.1,824.6,881.5,973.8,700.8,935.7,950.9,536.3,571.9,221.5,869.8,624.4,845.3,1068.9,1069.3,790.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["C9JRZ8","Aldo-keto reductase family 1 member B15 [OS=Homo sapiens]",5,2,7,1,316,36.5,6.7,14.99,"other metabolic processes","cytosol;mitochondrion","other molecular function","AKR1B15","ENSG00000227471","","Estrogen biosynthesis","",1.698,1.903,1.848,1.638,1.88,102.2,114.6,111.2,60.2,98.6,113.2,101,103.9,108.3,105,116.4,133.7,90,113,118.8,80.8,61.2,27.4,100.2,79.5,118.3,115,119.4,108.2,535.8,551.4,574.9,557.3,617.9,709.6,477.5,599.9,630.6,428.9,324.6,145.3,531.6,422,628.1,610.3,633.5,574.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P34059","N-acetylgalactosamine-6-sulfatase [OS=Homo sapiens]",5,1,1,1,522,58,6.74,3.22,"","non-structural extracellular;other cytoplasmic organelle","other molecular function","GALNS","ENSG00000141012","Glycosaminoglycan degradation; Metabolic pathways; Lysosome","Neutrophil degranulation; Keratan sulfate degradation; MPS IV - Morquio syndrome A","Glycosaminoglycan degradation",1.699,1.528,2.117,1.446,1.688,107.5,96.7,134,63.3,91.6,106.8,108,104.5,88.5,117.6,94,85.3,130.2,132.1,83.8,61.5,102.8,56.7,87.7,88.9,145.8,103.8,101.2,107.5,15.4,14.9,12.6,16.8,13.4,12.2,18.6,18.9,12,8.8,14.7,8.1,12.5,12.7,20.8,14.8,14.4,15.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y5S2","Serine/threonine-protein kinase MRCK beta [OS=Homo sapiens]",3,4,5,4,1711,194.2,6.37,8.61,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","kinase activity;other molecular function","CDC42BPB","ENSG00000198752","","CDC42 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle","VEGFA-VEGFR2 signaling pathway",1.702,2.017,1.67,1.286,1.648,109.5,129.8,107.5,64.4,82.8,106.1,108,94.1,110.7,90.8,128,148.3,70.7,106,117.7,76.7,63.5,21.2,77.9,81.6,141.5,100.1,158.5,104.6,1083.3,943.5,1110.2,911,1284.1,1487.2,709.4,1063.3,1180.3,769.1,636.6,212.7,781.1,818.7,1418.8,1003.8,1589.8,1049.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q13641","Trophoblast glycoprotein [OS=Homo sapiens]",2,1,1,1,420,46,6.83,2.32,"cell adhesion;cell-cell signaling;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","","TPBG","ENSG00000146242; ENSG00000283085","","","",1.739,1.103,1.062,0.934,1.074,151,95.7,92.2,86.8,81.1,93.2,125.6,153.8,148.3,76.6,94.1,111.9,89.3,90.6,91.5,72.9,85.3,142.7,79.7,87.5,77.3,91.6,96.1,85.2,148.9,182.5,176,90.9,111.6,132.8,105.9,107.5,108.6,86.5,101.2,169.3,94.5,103.8,91.7,108.6,114,101.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9Y6G1","Transmembrane protein 14A [OS=Homo sapiens]",6,1,1,1,99,10.7,10.55,0,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion;ER/Golgi","","TMEM14A","ENSG00000096092","","","",1.741,1.469,1.288,1.874,1.52,117.5,99.1,86.9,67.5,126.5,102.6,124.1,74.6,141.2,43.6,104.7,205.2,91.8,104.3,81.3,93.6,47.3,71.3,43.8,133.6,141.8,70.1,119.5,108.3,61.6,37,70.1,21.6,52,101.9,45.6,51.8,40.3,46.5,23.5,35.4,21.7,66.3,70.4,34.8,59.3,53.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q562F6","Shugoshin 2 [OS=Homo sapiens]",20,17,22,17,1265,144.7,7.91,67.01,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","","SGO2","ENSG00000163535","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Cohesin complex - Cornelia de Lange syndrome",1.795,1.566,1.708,1.699,1.549,115.6,100.9,110,64.4,109.4,99.7,115.4,117.6,114.3,101.3,95.7,100.7,111.9,109.8,107.4,60.6,64.3,72.9,106.8,109.2,114.4,101.1,99.5,97.1,1980.9,2018.8,1963,1739.5,1642.8,1728.1,1920.3,1884.6,1844.6,1039.7,1103.5,1251.9,1833.3,1874.6,1963.8,1736.2,1709,1666.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q502W6-1","von Willebrand factor A domain-containing protein 3B [OS=Homo sapiens]",1,1,2,1,1294,145.7,7.33,1.76,"","cytosol;nucleus","","VWA3B","ENSG00000168658","","","",1.826,1.948,2.116,1.767,2.016,102.6,109.5,119,56.2,99.3,113.3,113.6,96.4,101.8,104.3,108.6,122,70.6,118,134.5,75.6,55.7,40.4,98.5,81.2,160,90.7,112.4,115.8,82.8,70.3,74.2,76,79.2,89,51.5,86,98,55.1,40.6,29.4,71.8,59.2,116.7,66.2,81.9,84.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q92954-1","Proteoglycan 4 [OS=Homo sapiens]",0,1,1,1,1404,151,9.5,1.71,"transport;other biological processes","non-structural extracellular","other molecular function","PRG4","","","","",1.831,2.381,2.058,1.734,1.949,100.3,130.4,112.8,54.8,95,106.8,106.2,94.4,101.8,80.3,132.4,152.6,92.2,114.4,118.1,92.8,55.6,26,90.3,96.4,126.3,98.7,108.4,113.2,319.3,284.1,306.2,241.6,398.2,459,277.4,344.2,355.3,279,167.3,78.2,271.7,290,379.8,296.8,325.9,340.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P03928","ATP synthase protein 8 [OS=Homo sapiens]",13,1,2,1,68,8,9.91,5.52,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","MT-ATP8","ENSG00000228253","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome",1.847,1.449,1.528,1.484,1.688,123.2,96.7,101.9,66.7,99,112.6,83.6,118.4,136.6,90.7,92.9,117.5,97.9,67.2,101.3,64.1,153.4,7.4,149.7,95.1,92.1,163.4,108.2,60.6,790.9,1119.2,1292,857.6,878.3,1111.2,925.7,635.2,958.1,605.9,1450.1,69.7,1415.9,899,870.8,1544.9,1022.9,573.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P57721-1","Poly(rC)-binding protein 3 [OS=Homo sapiens]",26,9,184,1,371,39.4,8.07,779.48,"RNA metabolism OR transcription;other metabolic processes;other biological processes","other cell component","nucleic acid binding activity","PCBP3","ENSG00000183570","","","",1.847,1.606,1.688,1.708,1.561,117.8,102.4,107.6,63.8,108.9,99.5,121.1,102.5,122.7,109.3,94.1,105.3,110.7,110.6,101.2,65.5,74,58.2,111.9,84.9,121.8,106.2,102.3,97.8,41.7,35.3,42.2,37.6,32.4,36.3,38.1,38.1,34.9,22.6,25.5,20,38.5,29.2,41.9,36.6,35.2,33.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["O43298","Zinc finger and BTB domain-containing protein 43 [OS=Homo sapiens]",2,1,1,1,467,52.6,5.76,2.49,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB43","ENSG00000169155","","","",1.861,1.214,1.661,1.706,1.41,126.1,82.3,112.6,67.8,115.7,95.6,129.3,127.8,127,132.9,83.4,72.3,84.6,121.5,114.1,68.7,104.4,1,120.7,117.2,102.7,114.9,80.7,96.8,70.9,70.1,69.6,72.9,45.7,39.7,46.4,66.6,62.5,37.7,57.2,0.6,66.2,64.3,56.3,63,44.2,53.1,"High","High","High","High","High","High","High","High","High","High","High","Not Found","High","High","High","High","High","High"]
["Q8N9V7","Testis- and ovary-specific PAZ domain-containing protein 1 [OS=Homo sapiens]",1,1,2,1,1692,190.8,7.87,4.96,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol","","TOPAZ1","ENSG00000173769","","","",1.874,1.683,1.696,1.273,1.604,123.2,110.6,111.4,65.7,83.7,105.4,125.8,96.4,126.4,85.7,126.2,113,78.8,118.5,113.9,103.4,67.1,12.4,78.5,85.5,119.5,104.3,136.9,107.7,415.3,318.1,417.3,282.9,416.7,373,260.3,391.2,375.9,341.2,221.6,40.9,259,282.1,394.5,344.2,452.1,355.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P49321-2","Isoform 2 of Nuclear autoantigenic sperm protein [OS=Homo sapiens]",89,26,204,1,449,48.8,4.4,669.2,"","","","NASP","","","","",1.878,0.897,1.693,2.08,2.284,114.6,54.8,103.3,61,126.9,139.4,97.4,106.5,98.5,113.8,47.1,38.7,87.4,88.8,126,52.5,189.3,12.3,181.2,109.1,106.1,126,99.6,119.8,102.4,111.9,103.6,119.6,49.5,40.6,91.8,93.3,132.5,55.1,199,12.9,190.4,114.7,111.5,132.4,104.6,125.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q8NI77","Kinesin-like protein KIF18A [OS=Homo sapiens]",1,1,1,1,898,102.2,8.91,3.1,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KIF18A","ENSG00000121621","","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; MHC class II antigen presentation; RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",1.914,1.841,2.03,1.507,1.644,115.6,111.2,122.6,60.4,91,99.3,102.4,117.7,116.5,112,114.6,99.8,97.5,139.5,123.5,60.8,75.1,53.6,101.3,91.6,90.6,100,98.9,104.5,48,55.2,54.6,52.5,53.7,46.8,45.7,65.4,57.9,28.5,35.2,25.1,47.5,43,42.5,46.9,46.4,49,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q96FB5","Protein RRNAD1 [OS=Homo sapiens]",4,2,2,2,475,52.9,7.97,5.18,"RNA metabolism OR transcription;other metabolic processes","other membranes","other molecular function","METTL25B","ENSG00000143303","","","",1.938,1.369,1.305,1.262,1.202,144,101.7,97,74.3,93.8,89.3,146.8,142.7,139.7,99.8,110.3,100.8,88.1,103.2,96.1,73.6,65.2,85.6,92.9,93.4,91.7,88.5,86.3,95.2,245.7,238.7,233.7,166.9,184.5,168.6,147.4,172.7,160.8,123.2,109,143.2,155.5,156.3,153.4,148.1,144.4,159.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q86TG7-2","Isoform 2 of Retrotransposon-derived protein PEG10 [OS=Homo sapiens]",34,9,31,1,325,36.9,6.21,110.77,"","","","PEG10","","","","",1.948,1.674,1.665,1.63,1.502,124.1,106.7,106,63.7,103.9,95.7,117.1,123.4,115.8,96,100.7,108.8,101.2,88.5,100.1,60.1,55.1,153,97.8,98,98.7,89.6,105.5,90.3,453.1,477.4,448.1,371.6,389.5,421,391.6,342.4,387.3,232.6,213.3,591.9,378.3,379.3,382,346.5,408.2,349.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NYF3","protein FAM53C [OS=Homo sapiens]",3,1,2,1,392,43.1,8.65,5.36,"transport","nucleus","","FAM53C","ENSG00000120709","","","",1.961,1.348,1.623,1.697,1.709,126,86.6,104.3,64.3,109,109.8,128.1,98.6,136.2,96.2,77.5,88,106,122.8,88.1,72.3,65.3,63.3,122.2,110.8,98.6,120.9,111.6,93.4,63.6,49,67.6,47.8,38.5,43.7,52.6,60.9,43.7,35.9,32.4,31.4,60.7,55,49,60,55.4,46.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q13268","dehydrogenase/reductase SDR family member 2, mitochondrial [OS=Homo sapiens]",9,3,3,3,280,29.9,9.01,4.63,"other metabolic processes;stress response;developmental processes;other biological processes","mitochondrion;nucleus;other cell component","other molecular function","DHRS2","ENSG00000100867","","","",2.001,1.602,1.762,2.016,1.765,118.3,94.8,104.2,59.1,119.2,104.4,112.4,118.6,107,87.9,90,98,98.5,102.3,99,56.2,55.5,147.1,92.7,115.8,113.3,95.2,111.5,99.2,268.7,283.6,255.9,210.2,215.2,234.2,235.5,244.4,236.6,134.3,132.6,351.6,221.6,276.9,270.8,227.6,266.4,237.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q5VYV7","protein SLX4IP [OS=Homo sapiens]",7,2,5,2,408,45.5,9.42,7.37,"","","","SLX4IP","ENSG00000149346","","","Nucleotide excision repair in xeroderma pigmentosum",2.041,2.371,2.618,1.999,2.017,101.7,118.1,130.4,49.8,99.6,100.5,87.4,105.5,113.8,153.7,66,122.5,73,135.2,150.3,50.6,83.4,51.7,105.7,102.4,103.3,104.2,114.6,76.8,772.6,932.1,1005.3,1358.3,583,1082.5,645.5,1195.3,1328.5,447.2,737,456.6,934.6,905,912.8,920.9,1012.4,678.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BUV0","arginine/serine-rich protein 1 [OS=Homo sapiens]",9,3,3,3,290,33.6,11.77,7.46,"","","","RSRP1","ENSG00000117616","","","",2.068,1.793,2.164,2.223,2.242,108,93.6,113,52.2,116.1,117.1,106.6,97.9,111.5,92.4,87.1,95.2,120.5,104.7,111.6,49.7,51.6,72.8,113.5,114.7,122.4,115.1,115.6,117.1,381,349.9,398.3,330.2,311,340.2,430.5,374,398.5,177.7,184.2,260.2,405.4,409.6,437.1,411.3,413,418.2,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9BYN0","sulfiredoxin-1 [OS=Homo sapiens]",22,3,6,3,137,14.3,8.19,11.25,"stress response;other biological processes","cytosol;other cell component","other molecular function","SRXN1","ENSG00000271303","","","Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling",2.09,2.079,2.127,2.041,2.271,108,107.5,109.9,51.7,105.5,117.4,99.9,113.2,106.3,105.7,101.6,122.7,102.3,108.1,118.3,50.8,45.1,67.6,113.3,103,103.8,115.5,123.5,99.2,568.2,643.8,604.3,601,577.5,697.9,581.7,614.9,672.7,289.1,256.3,384.5,644.3,585.6,590,656.6,702.4,564.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9NQ25-7","Isoform 7 of SLAM family member 7 [OS=Homo sapiens]",32,4,13,1,188,21.3,6.02,48.57,"","","","SLAMF7","","","","",2.117,2.765,2.504,2.007,2.019,102.3,133.7,121,48.3,97,97.6,98.1,90.3,99.2,128.2,151.5,121.3,110.7,135.8,116.1,43.8,46.4,74,85.6,93.1,106.8,92.2,113.3,93.6,41.7,38.4,42.2,54.5,64.4,51.6,47.1,57.8,49.4,18.6,19.7,31.5,36.4,39.6,45.4,39.2,48.2,39.8,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P55042","GTP-binding protein RAD [OS=Homo sapiens]",17,4,11,4,308,33.2,8.88,39.74,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol","other molecular function","RRAD","ENSG00000166592","","NGF-stimulated transcription","Insulin signaling",2.159,2.299,2.738,3.375,3.444,86.3,91.9,109.4,40,134.9,137.6,83,89,85.5,84,91.1,97.4,92.4,108.4,112.8,38.5,39.6,63.1,132.1,133.7,138.5,133,141.7,136.4,846.9,908.3,872.9,857.8,929.5,994.5,943.3,1107,1151,393.1,404.3,643.8,1348.2,1364.7,1413.3,1357.3,1446.1,1392.5,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9HBH9-1","MAP kinase-interacting serine/threonine-protein kinase 2 [OS=Homo sapiens]",7,2,2,2,465,51.8,6.19,5.73,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","nucleus;other cell component","kinase activity;other molecular function","MKNK2","ENSG00000099875; ENSGGOG00000027137","MAPK signaling pathway; HIF-1 signaling pathway; Insulin signaling pathway","","Interleukin-1 (IL-1) structural pathway; MAPK signaling pathway; 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression; Malignant pleural mesothelioma",2.21,1.897,1.874,1.879,1.79,124.5,106.9,105.6,56.3,105.8,100.8,112.6,117.3,106.2,96,112,96.7,98.2,92.6,95.5,51,37.1,230.3,95.7,98.6,87.6,91.2,89.4,92.1,252.1,262.5,237.7,214.9,250.6,216.4,219.8,207.2,213.8,114.1,83.1,515.5,214.3,220.8,196,204.2,200.1,206.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P28039-1","Acyloxyacyl hydrolase [OS=Homo sapiens]",2,1,1,1,575,65.1,8.16,2.23,"other metabolic processes;other biological processes","non-structural extracellular;other cell component","other molecular function","AOAH","ENSG00000136250","","","",2.223,2.511,2.67,2.196,2.197,104.2,117.7,125.2,46.9,103,103,90.5,116.9,108.9,123,76.8,157.8,73.8,130.8,156.2,49,78.1,14.2,107.6,94.8,112.2,110.5,107.6,91.3,283.1,365.6,340.6,384.7,240.2,493.5,230.8,409.1,488.5,153.2,244.3,44.5,336.5,296.5,351.1,345.6,336.7,285.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q99574","Neuroserpin [OS=Homo sapiens]",12,5,6,5,410,46.4,4.91,13.82,"developmental processes;other biological processes","non-structural extracellular;other cell component","enzyme regulator activity","SERPINI1","ENSG00000163536","","","",2.229,2.293,2.162,1.631,1.632,122.2,125.7,118.5,54.8,89.4,89.4,117.6,115.5,123.7,122,116.9,121,102.9,114.1,114.1,52.8,52.7,124.3,86.1,79.7,93.4,85.8,86.1,91.2,510,501,536.5,529.1,506.9,524.5,446.3,494.6,494.8,228.8,228.7,539.1,373.1,345.5,405.1,372,373.3,395.4,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9H3M7","thioredoxin-interacting protein [OS=Homo sapiens]",48,12,24,12,391,43.6,7.5,64.03,"cell cycle OR cell proliferation;stress response;transport;developmental processes;signal transduction;other biological processes","cytosol;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","TXNIP","ENSG00000265972","NOD-like receptor signaling pathway","Cytoprotection by HMOX1; Regulation of FOXO transcriptional activity by acetylation; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection","VEGFA-VEGFR2 signaling pathway; Unfolded protein response",2.247,2.278,2.214,2.015,2.139,113.4,114.9,111.7,50.4,101.6,107.9,114.9,111,113.3,111.8,116.8,114.9,114,111.6,109.6,50.1,50.4,52.4,98,101.6,108.5,104.1,109.1,107.8,2369.8,2289.5,2336,2306.4,2409.2,2368.7,2350.7,2301.9,2260.1,1034.1,1039.6,1080.3,2021,2094.3,2237.5,2146.9,2250.9,2224.1,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P62937-2","Isoform 2 of Peptidyl-prolyl cis-trans isomerase A [OS=Homo sapiens]",90,12,899,1,105,11.4,7.9,1952.98,"","","","PPIA","","","","",2.31,3.105,2.667,2.072,2.518,101.4,136.3,117,43.9,90.9,110.5,101,103,110,90.8,138.4,165.6,73.1,118.9,128.1,70.4,44.6,24.3,92.4,70.6,119.7,110.4,126.7,112.3,663,676,722.2,596.3,908.8,1087.2,479.7,780.6,840.9,461.9,292.7,159.7,606.5,463.5,786.2,724.6,832.1,737,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P38936","Cyclin-dependent kinase inhibitor 1 [OS=Homo sapiens]",17,2,2,2,164,18.1,8.37,2.5,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","CDKN1A","ENSG00000124762","Endocrine resistance; Platinum drug resistance; ErbB signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Cell cycle; p53 signaling pathway; PI3K-Akt signaling pathway; Cellular senescence; JAK-STAT signaling pathway; Oxytocin signaling pathway; Parathyroid hormone synthesis, secretion and action; Cushing syndrome; Hepatitis C; Hepatitis B; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Pathways in cancer; Transcriptional misregulation in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Colorectal cancer; Renal cell carcinoma; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Thyroid cancer; Basal cell carcinoma; Melanoma; Bladder cancer; Chronic myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer","The role of GTSE1 in G2/M progression after G2 checkpoint; SCF(Skp2)-mediated degradation of p27/p21; Interleukin-4 and Interleukin-13 signaling; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; DNA Damage/Telomere Stress Induced Senescence; RUNX3 regulates CDKN1A transcription; Transcriptional  activation of  cell cycle inhibitor p21 ; Transcriptional regulation by RUNX2; Senescence-Associated Secretory Phenotype (SASP); Constitutive Signaling by AKT1 E17K in Cancer; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); FOXO-mediated transcription of cell cycle genes; AKT phosphorylates targets in the cytosol; Transcriptional regulation of granulopoiesis; p53-Dependent G1 DNA Damage Response; TFAP2 (AP-2) family regulates transcription of cell cycle factors; Signaling by FLT3 fusion proteins; STAT5 activation downstream of FLT3 ITD mutants","Androgen receptor signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase (AMPK) signaling; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; TP53 network; Cell cycle; Integrated cancer pathway; Glioblastoma signaling pathways; Adipogenesis; Retinoblastoma gene in cancer; ATM signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Aryl hydrocarbon receptor Netpath; Bladder cancer; Apoptosis-related network due to altered Notch3 in ovarian cancer; Vitamin D receptor pathway; miR-517 relationship with ARCN1 and USP1; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; lncRNA-mediated mechanisms of therapeutic resistance; Physico-chemical features and toxicity-associated pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Oxidative damage response; Endometrial cancer; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Type 2 papillary renal cell carcinoma; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Genotoxicity pathway; G1 to S cell cycle control; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; FGF23 signaling in hypophosphatemic rickets and related disorders; Overlap between signal transduction pathways contributing to LMNA laminopathies; p53 transcriptional gene network; Galanin receptor pathway; Malignant pleural mesothelioma; Orexin receptor pathway; Notch signaling pathway (Netpath); Senescence and autophagy in cancer; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent); Androgen receptor signaling pathway",2.325,1.505,2.215,2.548,2.36,116.7,75.6,111.2,50.2,127.9,118.5,100.2,77.2,93.4,61.7,52.1,60.4,92.8,82.8,88.9,40.2,35.3,426.9,102.3,92.5,105.9,100,92.7,94.8,60.9,46.9,56.7,37.5,31.7,36.7,56.4,50.3,54,24.4,21.4,259.3,62.2,56.2,64.3,60.7,56.3,57.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["P04053","DNA nucleotidylexotransferase [OS=Homo sapiens]",3,1,1,1,509,58.5,8.43,2.25,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DNTT","ENSG00000107447","Non-homologous end-joining; Hematopoietic cell lineage","","",2.464,2.025,2,1.749,1.79,134.1,110.2,108.8,54.4,95.2,97.4,149.3,98.2,146,119.9,112.5,133.3,133,74.8,118.4,52.4,59.2,72.9,18.6,106.5,103.6,77.7,117.7,106,21,13.8,20.5,16.9,15.8,18.7,18.7,10.5,16.7,7.4,8.3,10.3,2.6,15,14.6,10.9,16.6,14.9,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q6ZV73-1","FYVE, RhoGEF and PH domain-containing protein 6 [OS=Homo sapiens]",1,1,1,1,1430,160.7,7.03,0,"cell organization and biogenesis;other biological processes","cytoskeleton;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","FGD6","ENSG00000180263","","","",2.601,3.021,2.615,2.526,2.759,107.5,124.8,108,41.3,104.4,114,85.8,115,126.1,133.6,79.2,146.9,72.4,115.6,153.4,44.2,72.2,0.2,113.3,93,111.7,122,133.8,81.5,333.4,447.3,490.2,519.5,307.8,571.2,281.3,449.6,596.5,171.9,280.8,1,440.7,361.7,434.3,474.3,520.3,316.7,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q02509","Otoconin-90 [OS=Homo sapiens]",2,1,2,1,493,53.4,4.94,0,"","","","","","","","",2.782,3.726,3.28,2.431,2.662,105.1,140.8,123.9,37.8,91.8,100.6,88.2,114.7,117.4,157.7,52.9,153.6,62.8,135.2,169.2,41.2,80,20.4,100.2,100.7,90.6,109.7,140.8,64.6,293.6,381.8,390.8,525.1,176.2,511.2,209.1,450.1,563.3,137.2,266.2,67.9,333.5,335.1,301.7,365.3,468.6,215,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UBN6","Tumor necrosis factor receptor superfamily member 10D [OS=Homo sapiens]",9,2,2,2,386,41.8,6.54,5.56,"signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","TNFRSF10D","ENSG00000173530","Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor","Cell surface interactions at the vascular wall; TP53 Regulates Transcription of Death Receptors and Ligands; TRAIL  signaling","p53 transcriptional gene network",3.148,3.24,3.293,3.497,3.409,107.4,110.5,112.3,34.1,119.3,116.3,93.1,107.1,114.1,123.8,110.3,99.5,112.1,108.4,115.8,32.5,36.4,34,124.3,107.8,119,116,108.4,137.5,63,72.5,77.2,83.7,74.6,67.3,75.8,73.3,78.4,22,24.6,23,84.1,72.9,80.5,78.5,73.3,93,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q86TG7-1","Retrotransposon-derived protein PEG10 [OS=Homo sapiens]",22,12,39,4,708,80.1,6.39,131.72,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PEG10","ENSG00000242265","","","",3.183,2.799,2.663,2.457,2.372,131.9,116,110.4,41.5,101.9,98.3,128.8,138.7,129.2,108.6,113.6,121.9,109.3,105,108.1,39.4,40.6,63.7,103.2,98.8,99.7,96.3,104.2,91.2,4319.9,4653.6,4332.7,3643.5,3810,4089.3,3665.3,3522.9,3625.3,1321.2,1361.4,2135.8,3461.9,3313,3345.4,3229.3,3495.4,3059.3,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q15049","Membrane protein MLC1 [OS=Homo sapiens]",4,1,1,1,377,41.1,7.49,3.04,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","MLC1","ENSG00000100427","","","",3.31,4.255,4.117,3.042,3.049,105.8,136,131.6,32,97.2,97.4,97.2,114,125.8,162.4,47.6,146.6,55.8,141.8,178.9,34.4,80.1,6.6,94.3,104.7,115.7,105,125.4,63.6,387.7,454.4,501.4,647.6,189.7,584.2,222.5,565.3,713.3,137.3,319.4,26.3,376,417.6,461.1,418.5,500,253.5,"High","High","High","High","High","High","High","High","High","High","High","Not Found","High","High","High","High","High","High"]
["O43301","Heat shock 70 kDa protein 12A [OS=Homo sapiens]",2,1,4,1,675,74.9,6.77,0,"","nucleus;other cell component","other molecular function","HSPA12A","ENSG00000165868","","Regulation of HSF1-mediated heat shock response","",3.495,4.493,4.897,2.877,3.598,103,132.4,144.3,29.5,84.8,106,85.5,103.3,108.6,132.8,58.1,228.1,59.8,144.7,223.6,29.6,51.6,1.4,85,80.3,116.3,120.1,106.3,64.9,209,252.5,265.4,324.5,142.1,557.5,146.1,353.8,546.6,72.2,126.1,3.4,207.9,196.3,284.3,293.5,259.9,158.6,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]
["Q9UPT6","C-Jun-amino-terminal kinase-interacting protein 3 [OS=Homo sapiens]",4,7,12,4,1336,147.4,5.4,32.57,"cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","MAPK8IP3","ENSG00000138834","MAPK signaling pathway","","MAPK signaling pathway",3.689,3.712,3.435,3.179,3.037,122.6,123.4,114.2,33.2,105.7,100.9,125.7,118.3,123.5,127.1,124.2,116.5,100.9,115,115.8,33.1,33.5,51.5,106.4,100,106.5,98,101.7,102.3,926.3,871.9,910,936.7,915.5,858.6,743.4,847.2,853.1,244,246.7,379.3,784,737,785,722.3,749.1,754,"High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High","High"]

{"sheet":"ARV825","index":1,"n_rows":7310,"n_cols":32,"rows_kept":2250,"cut":true,"bounds":{"rows_first":1000,"rows_last":250,"rows_between":1000,"halvings":1}}
["Accession","Description","Coverage [%]","# Peptides","# PSMs","# Unique Peptides","# AAs","MW [kDa]","calc. pI","Score Sequest HT: Sequest HT","Biological Process","Cellular Component","Molecular Function","Gene Symbol","Ensembl Gene ID","KEGG Pathways","Reactome Pathways","WikiPathways","Abundances (Normalized): F7: 127N, Sample, ARV","Abundances (Normalized): F7: 128N, Sample, ARV","Abundances (Normalized): F7: 129N, Sample, ARV","Abundances (Normalized): F7: 126, Sample, DMSO","Abundances (Normalized): F7: 127C, Sample, DMSO","Abundances (Normalized): F7: 128C, Sample, DMSO","Ratio","log2(Ratio)","P-Value","− log10(P-Value)","q-Value","− log10(q-Value)","Rank (P-Value)"]
["A0A096LP01","Small integral membrane protein 26 [OS=Homo sapiens]",17,1,1,1,95,10.9,6.7,3.05,"","other membranes","","SMIM26","ENSG00000232388","","","",62,72.5,66.4,251.3,281.5,85.3,{"$f":"AVERAGE(S2:U2)/AVERAGE(V2:X2)","v":0.32502831257078146},{"$f":"LOG(Y2,2)","v":-1.621362700972778},{"$f":"TTEST(S2:U2,V2:X2,2,2)","v":0.08504787750684428},{"$f":"-LOG10(AA2)","v":1.070336520364964},{"$f":"AA2*7309/AE2","v":0.3155405770038197},{"$f":"-LOG10(AC2)","v":0.500944784642584},1970]
["A0A0B4J2F0","Protein PIGBOS1 [OS=Homo sapiens]",19,1,1,1,54,6.3,8.5,3.82,"stress response;other biological processes","other membranes;mitochondrion","","PIGBOS1","ENSG00000225973","","","",56,74.9,72.6,42.3,98.1,55.7,1.0377358490566038,0.053439258961460415,0.896713541548767,0.04734627177612972,0.9307127627350097,0.03118433062632218,7042]
["A0A1B0GVM6","Uncharacterized protein C11orf97 [OS=Homo sapiens]",6,1,1,1,126,13.9,9.35,2.08,"","cytoskeleton;other cell component","","C11orf97","ENSG00000257057","","","",170,166.8,162.2,184.6,165.2,271.8,0.802767052767053,-0.31694668818308686,0.2815318370289508,0.5504724858422233,0.514686392407354,0.28845731374034844,3998]
["A0AV96","RNA-binding protein 47 [OS=Homo sapiens]",22,9,24,9,593,64.1,7.68,76.54,"RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus","nucleic acid binding activity","RBM47","ENSG00000163694","","","TYROBP causal network in microglia",1434.2,1423.7,1423,2427.4,2137.3,2465,0.6089733559042347,-0.7155489868636771,9.0234927921349812E-4,3.044625324239247,0.03364934123352785,1.4730234337117498,196]
["A0AVK6","Transcription factor E2F8 [OS=Homo sapiens]",2,1,1,1,867,94.1,8.98,2.02,"cell cycle OR cell proliferation;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","E2F8","ENSG00000129173","","TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest","Genotoxicity pathway",67.5,58.9,76,55.7,63.9,429.8,0.36840189297415366,-1.440647620381546,0.40184580062974673,0.3959405657779608,0.578737134345383,0.23751865047923837,5075]
["A0AVT1-1","Ubiquitin-like modifier-activating enzyme 6 [OS=Homo sapiens]",46,38,125,37,1052,117.9,6.14,376.11,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","UBA6; UBE1L2","ENSG00000033178","Ubiquitin mediated proteolysis","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation","",12501.1,12261.6,12411.7,11917.7,11594.7,13800.7,0.9962828068426369,-0.005372768140693671,0.949894000664042,0.022324855232343066,0.9669603413444962,0.014591337590670458,7180]
["A0FGR8-2","Isoform 2 of Extended synaptotagmin-2 [OS=Homo sapiens]",31,20,56,20,893,98.8,8.68,171.95,"","","","ESYT2","","","","",4393.3,4250.7,4277.1,3942.7,3944,5552,0.9614843697679092,-0.05666469009557725,0.7644987175682129,0.1166232387716293,0.8386194096812348,0.07643509015579275,6663]
["A0JLT2","Mediator of RNA polymerase II transcription subunit 19 [OS=Homo sapiens]",5,1,1,1,244,26.3,9.82,3.01,"other biological processes","nucleus","other molecular function","MED19","ENSG00000156603","","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","",114.1,116.7,109.8,105.2,117.4,226.6,0.7582368655387355,-0.39927949272205887,0.401949117590539,0.3958289204187054,0.5787718874052895,0.23749257195739953,5076]
["A0JNW5-1","UHRF1-binding protein 1-like [OS=Homo sapiens]",9,10,15,10,1464,164.1,6.32,37.87,"","cytosol;other cytoplasmic organelle","other molecular function","UHRF1BP1L","ENSG00000111647","","RND2 GTPase cycle","",1049.3,1008.3,1013.7,1131,1203.2,1931.1,0.7200665838276324,-0.47379777761505254,0.1947715751371647,0.7104744235448183,0.4418328499930282,0.35474199774404447,3222]
["A0MZ66","Shootin-1 [OS=Homo sapiens]",37,24,49,24,631,71.6,5.33,145.6,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SHTN1","ENSG00000187164","","Recycling pathway of L1","",6037.2,6022.9,6076.3,6728.1,6456.4,8164.3,0.8495278423143221,-0.23526686400457364,0.11349540240995735,0.9450217309680161,0.3557195095258912,0.44889231517101963,2332]
["A0PJW6","Transmembrane protein 223 [OS=Homo sapiens]",4,1,1,1,202,22,11.02,3.28,"developmental processes","other membranes","","TMEM223","ENSG00000168569","","","",21.1,19.7,19.5,21.1,21,122.1,0.3672350791717418,-1.4452242198777199,0.3620104905706803,0.4412788440222361,0.5577433970449204,0.2535655624944694,4744]
["A0PK00","Transmembrane protein 120B [OS=Homo sapiens]",9,2,2,2,339,40.2,8.9,9.39,"cell organization and biogenesis;transport;other biological processes","other membranes;nucleus","","TMEM120B","ENSG00000188735","","","",254.7,257.6,274.7,219.3,255,285.2,1.0362080315997366,0.051313671005402905,0.6711403242764098,0.1731866665858627,0.7701938499193405,0.11339995358755095,6369]
["A1A4S6","Rho GTPase-activating protein 10 [OS=Homo sapiens]",23,14,19,14,786,89.3,7.18,61.26,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","enzyme regulator activity","ARHGAP10","ENSG00000071205","Bacterial invasion of epithelial cells","Regulation of PAK-2p34 activity by PS-GAP/RHG10; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle","Ectoderm differentiation; Ectoderm differentiation",1479.7,1530.8,1531.9,1464.4,1402.6,1580.4,1.0213607950712777,0.030492587384256628,0.5948885398804807,0.2255643973796386,0.7126766657902694,0.14710746048805312,6101]
["A1L0T0","Acetolactate synthase-like protein [OS=Homo sapiens]",30,13,32,13,632,67.8,8.15,108.67,"other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","ILVBL","ENSG00000105135","","","",2313.4,2280.2,2257.2,2179.6,2147.2,2475.2,1.0071743604822112,0.010313462121130119,0.8850594795855601,0.05302754197135062,0.9222839658241886,0.035135341632861396,7014]
["A2AJT9-1","BCLAF1 and THRAP3 family member 3 [OS=Homo sapiens]",3,2,2,2,711,83.8,9.7,4.71,"other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","BCLAF3","ENSG00000173681","","","",140.3,125.7,127.9,210.3,232.3,338.7,0.5041597337770382,-0.9880471972382349,0.0317934799860234,1.4976619333619956,0.20101950278360298,0.696761805562533,1156]
["A2RRP1-1","neuroblastoma-amplified sequence [OS=Homo sapiens]",17,31,67,31,2371,268.4,5.96,179.73,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","NBAS","ENSG00000151779","","COPI-dependent Golgi-to-ER retrograde traffic","",4963.6,4901.9,4895.3,4878.7,4713.7,6019.2,0.9455020625688592,-0.08084748953663125,0.5281413962334632,0.27724979075582706,0.6677366312178485,0.17539479824696952,5781]
["A2RTX5","Probable threonine--tRNA ligase 2, cytoplasmic [OS=Homo sapiens]",20,13,26,11,802,92.6,6.05,55.39,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","other molecular function","TARS3","ENSG00000185418","Aminoacyl-tRNA biosynthesis","","",1152,1145.9,1102.8,1143.6,1083.2,1076.6,1.0294545014227763,0.041880068899494145,0.28577332084308027,0.5439783184123167,0.5173934114545636,0.28617910593865825,4037]
["A2RU49","Hydroxylysine kinase [OS=Homo sapiens]",5,1,1,1,373,41.9,6.84,3.01,"other metabolic processes","mitochondrion","kinase activity","HYKK","ENSG00000188266","Lysine degradation; Metabolic pathways","Lysine catabolism","",25.6,33.3,22.9,35.9,27.7,126.8,0.4296218487394958,-1.2188607303661947,0.3199504573636735,0.4949172646779572,0.5369731097292973,0.27004746213766617,4355]
["A2RU67","Protein FAM234B [OS=Homo sapiens]",6,3,6,3,622,67,5.02,18.88,"","other membranes;cytoskeleton;ER/Golgi","","FAM234B","ENSG00000084444","","","",404.9,423.1,418.8,474,475.7,618.1,0.795254496747034,-0.33051147041580914,0.09000546362443164,1.0457311266726597,0.324064006714764,0.4893692027018996,2030]
["A2RUC4","tRNA wybutosine-synthesizing protein 5 [OS=Homo sapiens]",7,2,4,2,315,36.5,7.55,10.06,"RNA metabolism OR transcription;other metabolic processes","other cell component","nucleic acid binding activity;other molecular function","TYW5","ENSG00000162971","","Synthesis of wybutosine at G37 of tRNA(Phe)","",281.7,233.3,253.2,249.7,247.3,250.2,1.028104925053533,0.03998750882140294,0.6450187403019447,0.1904276672383902,0.750946475448696,0.12439101671844091,6278]
["A2RUR9","Coiled-coil domain-containing protein 144A [OS=Homo sapiens]",2,3,7,2,1427,165,5.36,13.7,"","","","CCDC144A","ENSG00000170160","","","",133.7,123.2,114.4,107,121.1,198.6,0.8701663932505272,-0.2006367953463712,0.5591057580578682,0.2525060350532898,0.68947258067234,0.16148300040833496,5927]
["A2RUS2","DENN domain-containing protein 3 [OS=Homo sapiens]",9,7,10,7,1198,135.8,7.06,23.16,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol;other cell component","enzyme regulator activity","DENND3","ENSG00000105339","","RAB GEFs exchange GTP for GDP on RABs","",652.8,643.2,663.4,735.7,702.1,775.8,0.8851644380195156,-0.17598260367103238,0.018517941189751762,1.7324072994916973,0.15719817904285208,0.803552489061379,861]
["A3KMH1","von Willebrand factor A domain-containing protein 8 [OS=Homo sapiens]",14,19,30,19,1905,214.7,7.4,99.05,"","mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","VWA8","ENSG00000102763","","","",2896.8,2956.4,2964.5,2826.6,2908.5,3020.7,1.0070695995797072,0.010163392876634827,0.7489326152217459,0.125557255937201,0.8286328314646898,0.08163786340862345,6606]
["A3KN83-1","protein strawberry notch homolog 1 [OS=Homo sapiens]",6,5,8,5,1393,154.2,7.88,19.95,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","SBNO1","ENSG00000139697","","","",124.6,144.6,123.6,119.2,118,125.7,1.082391843483053,0.11422287283535872,0.24096653848153532,0.6180432610009543,0.48265947650357405,0.3163591624816296,3649]
["A4D1E9-1","GTP-binding protein 10 [OS=Homo sapiens]",26,8,19,8,387,42.9,9.03,60.89,"other biological processes","mitochondrion;nucleus;other cell component","other molecular function","GTPBP10","ENSG00000105793","","","",1650.6,1615.8,1661.7,1626,1598.6,2402.9,0.8757174589071524,-0.19146262047609408,0.4270944519731951,0.3694760700929055,0.5939180649680523,0.2262734647606569,5256]
["A4D1P6-1","WD repeat-containing protein 91 [OS=Homo sapiens]",18,10,19,10,747,83.3,6.58,71.16,"transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle","enzyme regulator activity","WDR91","ENSG00000105875","","CDC42 GTPase cycle","",1786.9,1822.3,1867.8,1910,1861.6,1666.9,1.0070791578560265,0.010177085686358564,0.8771295276032077,0.05693626869825484,0.9168964126504356,0.037679726440628454,6992]
["A5A3E0","POTE ankyrin domain family member F [OS=Homo sapiens]",13,11,339,2,1075,121.4,6.2,1022.65,"","other cell component","","POTEF","ENSG00000196604","","","",467.7,472.9,486.6,364.9,434.4,225.5,1.3926619828259172,0.4778451395786582,0.09530147529616882,1.0209003762973918,0.3310639177470047,0.48008814989512033,2104]
["A5LHX3","proteasome subunit beta type-11 [OS=Homo sapiens]",5,1,1,1,300,32.5,6.46,2.88,"protein metabolism;other metabolic processes;developmental processes","cytosol;nucleus;other cell component","other molecular function","PSMB11","ENSG00000222028","Proteasome","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling","",34.4,35.5,34.9,33.2,26.9,108.3,0.6223277909738718,-0.6842534215289456,0.46298915397780566,0.3344291826813166,0.6210291294593102,0.2068880287014525,5449]
["A5PLN9-1","Trafficking protein particle complex subunit 13 [OS=Homo sapiens]",4,2,4,2,417,46.5,5.6,9.61,"","cytosol;ER/Golgi","","C5orf44; TRAPPC13","ENSG00000113597","","RAB GEFs exchange GTP for GDP on RABs","",464.3,423.2,464.4,481.4,491.6,621,0.8481179422835634,-0.23766318986787513,0.16095284182000535,0.7933013509084622,0.4127734459166383,0.38428824903299946,2850]
["A5YKK6","CCR4-NOT transcription complex subunit 1 [OS=Homo sapiens]",19,40,103,40,2376,266.8,7.11,284.22,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","CNOT1","ENSG00000125107","RNA degradation","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","Ciliary landscape",8643.8,8289.9,8541.3,9575.5,9325.3,14309,0.7670928460876005,-0.3825268881063524,0.18768766531501282,0.7265642679308499,0.4364648888919595,0.360050687064457,3143]
["A6NC62","Putative RBAK downstream neighbor protein [OS=Homo sapiens]",6,1,1,1,111,12.3,8.76,2.34,"","","","RBAKDN","","","","",151,162.9,161.4,161.9,173.2,181.8,0.9195202166763393,-0.12104680064376909,0.11372086825486062,0.9441598331457235,0.35627339308820244,0.4482166100555032,2333]
["A6NC98","Coiled-coil domain-containing protein 88B [OS=Homo sapiens]",41,50,114,50,1476,164.7,5.11,346.24,"cell organization and biogenesis;stress response;transport;other biological processes","cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","CCDC88B","ENSG00000168071","","","",8669.6,8410.2,8537.8,9566.4,9578.2,10639.8,0.8601012610628384,-0.21742157433632275,0.01878653167117709,1.7261533910066258,0.15819211979796466,0.8008151542991447,868]
["A6ND36-1","Protein FAM83G [OS=Homo sapiens]",3,2,2,2,823,90.8,6.39,5.4,"signal transduction","cytosol;nucleus","other molecular function","FAM83G","ENSG00000188522","","","",52.1,51.6,56,76.3,65,124.5,0.6008276899924754,-0.7349767918649424,0.12539238656567578,0.901728831710188,0.36866168680954314,0.43337199413184097,2486]
["A6NDG6","glycerol-3-phosphate phosphatase [OS=Homo sapiens]",38,10,26,10,321,34,6.14,84.02,"protein metabolism;other metabolic processes;other biological processes","other cell component","other molecular function","PGP","ENSG00000184207","Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism","Glycolysis","",3483.2,3477.8,3429.5,3260.2,3459.1,3532.5,1.0135293314344798,0.01938784085488125,0.6076776338646748,0.21632674796716117,0.7216110196453139,0.14169684335052338,6155]
["A6NDU8","UPF0600 protein C5orf51 [OS=Homo sapiens]",42,8,16,8,294,33.6,5.26,52.53,"","cytosol;nucleus","","C5orf51","ENSG00000205765","","","",1483.7,1439.7,1420.1,1512.7,1549.9,888.6,1.0992862927718159,0.13656716369687855,0.5764389965937597,0.23924664646907834,0.7017309503837091,0.1538293681563382,6004]
["A6NED2","RCC1 domain-containing protein 1 [OS=Homo sapiens]",7,1,2,1,376,40.1,5.27,8.95,"cell organization and biogenesis","plasma membrane;other membranes;cytosol;other cell component","","RCCD1","ENSG00000166965","","","",12.1,15.4,13.2,10.1,13.5,17.5,0.9902676399026764,-0.014109599415435842,0.9574443157623633,0.018886474863636097,0.9723441022519264,0.012180015667156171,7197]
["A6NEE1","Pleckstrin homology domain-containing family D member 1 [OS=Homo sapiens]",1,1,3,1,506,59.2,6.44,6.54,"","","","PLEKHD1","ENSG00000175985","","","",437.6,460.9,453.9,566.3,547.1,640.4,0.7711255559356825,-0.3749623136338316,0.010252050849325758,1.9891892484176785,0.11617401497321235,0.9348910011689734,645]
["A6NF36","Coiled-coil domain-containing protein 182 [OS=Homo sapiens]",5,1,1,1,153,17.5,6.58,2.1,"developmental processes","","","CCDC182","ENSG00000166329","","","",323.2,349.3,342.4,299.4,278.1,163,1.3705604321404457,0.45476594233893436,0.10097304952423392,0.9957945272547177,0.33822732308552966,0.47079131162306787,2182]
["A6NFI3","Zinc finger protein 316 [OS=Homo sapiens]",1,1,1,1,1004,108.4,5.31,1.81,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF316","ENSG00000205903","Herpes simplex virus 1 infection","","",84.6,98.3,97.3,130.7,138,329.6,0.4683269262911583,-1.0944121072241375,0.17956809335218266,0.7457708286491914,0.4298929558830996,0.36663967106388023,3053]
["A6NFQ2","TRPM8 channel-associated factor 2 [OS=Homo sapiens]",10,7,10,7,919,100.8,7.17,35.62,"other biological processes","plasma membrane;other membranes;other cell component","other molecular function","TCAF2","ENSG00000170379","","","",724,747.8,732.6,721.7,739.8,932.8,0.9206866307480266,-0.11921789752392427,0.4040412975060395,0.3935742429033411,0.5798424982273007,0.23668995719554636,5093]
["A6NHR9-1","structural maintenance of chromosomes flexible hinge domain-containing protein 1 [OS=Homo sapiens]",19,35,74,35,2005,226.2,7.3,199.26,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SMCHD1","ENSG00000101596","","","",8752.2,8875.8,8831.6,9475,9740.7,10286.6,0.8968656681004532,-0.15703617939521716,0.013721613341041834,1.8625948227459317,0.13407924052095557,0.8726384587264201,748]
["A6NI79","Coiled-coil domain-containing protein 69 [OS=Homo sapiens]",15,5,6,5,296,34.8,5.76,11.39,"cell cycle OR cell proliferation;cell organization and biogenesis","cytoskeleton;nucleus;other cell component","cytoskeletal activity","CCDC69","ENSG00000198624","","","",556.2,546.1,547.4,518.2,518.1,400.8,1.1479368172013082,0.19904323781599204,0.14526416729775538,0.837841501077423,0.39646594427904935,0.40179411186944014,2678]
["A6NIH7","Protein unc-119 homolog B [OS=Homo sapiens]",35,5,10,5,251,28.1,5.68,36.45,"cell organization and biogenesis;transport;developmental processes","cytosol;other cell component","other molecular function","UNC119B","ENSG00000175970","","Trafficking of myristoylated proteins to the cilium","",822.7,862.2,825.5,801.2,836.9,1088.4,0.9207408765816982,-0.11913289803853797,0.47409965612192184,0.32413035968717274,0.6286637130978097,0.2015816067027692,5512]
["A6NJ78","Probable methyltransferase-like protein 15 [OS=Homo sapiens]",16,4,5,4,407,46.1,8.62,15.12,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","other molecular function","METTL15","ENSG00000169519","","","",167.1,164.3,180.2,170.3,160.6,214.8,0.9375114531794025,-0.09309177949100564,0.5490471081943205,0.2603903915223346,0.6828288776233262,0.16568812035276048,5877]
["A6NK58","Putative lipoyltransferase 2, mitochondrial [OS=Homo sapiens]",4,1,1,1,231,25.2,8.27,2.54,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","other molecular function","LIPT2","ENSG00000175536","Lipoic acid metabolism; Metabolic pathways; Biosynthesis of cofactors","Glyoxylate metabolism and glycine degradation","",69.1,75.7,76,78.9,84.2,198.5,0.6106194690265487,-0.7116545056370185,0.2960009248689403,0.5287069319652177,0.5243506446599818,0.2803781937183774,4126]
["A6NK97-2","Isoform 2 of Solute carrier family 22 member 20 [OS=Homo sapiens]",5,1,1,1,347,37,7.78,0,"","","","SLC22A20P","","","","",33.1,30.2,24.3,25,16.6,38.5,1.0936329588014981,0.12912862719246332,0.7348730323004538,0.133787689670287,0.8181549113608555,0.0871644582118122,6565]
["A6NKF1","SAC3 domain-containing protein 1 [OS=Homo sapiens]",7,2,2,2,404,43.5,8.69,6.58,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;nucleus;other cell component","","SAC3D1","","","","",189.5,175.2,176.6,223.8,183.7,237.9,0.8387046792686705,-0.2537651897723001,0.10869940158809528,0.9637728467849427,0.34769537251964483,0.45880108930683877,2285]
["A7E2V4","Zinc finger SWIM domain-containing protein 8 [OS=Homo sapiens]",6,6,7,6,1837,197.2,6.8,22.41,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","other molecular function","ZSWIM8","ENSG00000214655","","Regulation of expression of SLITs and ROBOs","",517,508.8,508.4,590.7,586.6,896.1,0.7399440532458762,-0.4345119013836471,0.1544724298234487,0.8111490220255363,0.4067143334220413,0.3907105219243806,2776]
["A8MVU1","Putative neutrophil cytosol factor 1C [OS=Homo sapiens]",33,8,20,8,366,41.8,8.84,66.73,"other metabolic processes","other cell component","enzyme regulator activity;other molecular function","NCF1C","","","","",1295.4,1244.5,1299,1575.4,1490.5,2348.5,0.7090166962174942,-0.4961084938449032,0.12726626375664185,0.8952867055850956,0.3711848051864706,0.43040981035925385,2506]
["A8MW92","PHD finger protein 20-like protein 1 [OS=Homo sapiens]",1,1,1,1,1017,114.9,6.83,2.6,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","PHF20L1","ENSG00000129292","","","",51.8,47.1,59.3,77.4,78,64.2,0.7204007285974497,-0.47312845453240715,0.02341469744394832,1.6305114496381536,0.17624925192360275,0.7538727176621854,971]
["A8MXV4","nucleoside diphosphate-linked moiety X motif 19 [OS=Homo sapiens]",12,2,13,2,375,42.2,7.64,35.47,"other metabolic processes","cytosol;other cytoplasmic organelle","other molecular function","NUDT19","ENSG00000213965","Peroxisome","Peroxisomal lipid metabolism; Peroxisomal protein import","",1168.1,1095.4,1121.3,968.4,908.5,307.5,1.5495330525544773,0.6318335288820867,0.13227373844871632,0.8785263718285938,0.37809493716138737,0.42239913797095635,2557]
["A9UHW6","MIF4G domain-containing protein [OS=Homo sapiens]",18,4,6,4,222,25.4,5.33,20.28,"other biological processes","cytosol;ER/Golgi;nucleus","nucleic acid binding activity;other molecular function","MIF4GD","ENSG00000125457","","","",458.2,434.6,432.6,574.4,609.8,916,0.6310827540234264,-0.6640988963497008,0.07643369805787183,1.1167151276284952,0.30067486496500817,0.5219028754021451,1858]
["B2RTY4","unconventional myosin-IXa [OS=Homo sapiens]",1,3,4,3,2548,292.5,8.88,9.32,"cell organization and biogenesis;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","MYO9A","ENSG00000066933","","RHOA GTPase cycle; RHOB GTPase cycle; RHOV GTPase cycle","",212.6,197.6,216.5,203.7,199,631.4,0.6060342326660865,-0.7225288063001611,0.3974769696964591,0.4006880298339283,0.5764204705379801,0.2392606043954807,5040]
["B5ME19","eukaryotic translation initiation factor 3 subunit C-like protein [OS=Homo sapiens]",44,41,177,1,914,105.4,5.64,520.95,"cell organization and biogenesis;protein metabolism;other metabolic processes","translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3CL","ENSG00000205609","","","",602.4,558.8,587.9,681.2,692.4,1038.4,0.7251658374792703,-0.4636171334844908,0.13428664693682235,0.8719671701307683,0.3813135596197493,0.4187177508151632,2574]
["B7ZC32","Kinesin-like protein KIF28P [OS=Homo sapiens]",1,1,1,1,967,108.2,8.43,1.83,"cell organization and biogenesis;transport;other biological processes","other membranes;cytoskeleton;mitochondrion","cytoskeletal activity;other molecular function","KIF28P","","","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",97.9,83.7,83.4,74.7,69.1,108,1.0524225575853852,0.07371407661890728,0.7529417037142454,0.12323864761776315,0.8311812282808367,0.08030427361510764,6621]
["B9A064-1","Immunoglobulin lambda-like polypeptide 5 [OS=Homo sapiens]",48,8,196,8,214,23,8.84,691.91,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","IGLL5","ENSG00000254709","","","",29313.6,27552,27448.9,42363.8,37975.4,53210.2,0.6313356705458802,-0.6635208290298906,0.022905158549513728,1.6400666976909708,0.1740268231168356,0.7593838078448109,962]
["C9J798","Ras GTPase-activating protein 4B [OS=Homo sapiens]",17,12,17,12,803,90.4,7.74,47.22,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol","enzyme regulator activity;other molecular function","RASA4B","ENSG00000170667","","","Ras signaling",1896.2,1796.8,1849.2,1996.9,2038.5,2414.6,0.8592558139534883,-0.21884038659821176,0.089963520549451,1.045933557624099,0.3240726326741929,0.48935764277347205,2029]
["C9JI98","Transmembrane protein 238 [OS=Homo sapiens]",6,1,1,1,176,18,11.53,2.83,"","other membranes","","TMEM238","ENSG00000233493","","","",154.8,151.5,153.7,141.9,164.1,152,1.0043668122270744,6.2862628474314565E-3,0.923129218322488,0.034737502791510916,0.9490999376451068,0.02268805513577543,7109]
["C9JRZ8","Aldo-keto reductase family 1 member B15 [OS=Homo sapiens]",5,2,7,1,316,36.5,6.7,14.99,"other metabolic processes","cytosol;mitochondrion","other molecular function","AKR1B15","ENSG00000227471","","Estrogen biosynthesis","",535.8,551.4,574.9,428.9,324.6,145.3,1.849243435692034,0.8869351546222193,0.03826282741258959,1.4172229411483472,0.21413706398056453,0.6693081562034293,1306]
["L0R6Q1","SLC35A4 upstream open reading frame protein [OS=Homo sapiens]",47,5,18,5,103,11.1,8.1,62.31,"stress response","other membranes","","SLC35A4","ENSG00000176087","","","",2248.3,2447.5,2599.3,1898.8,2251.4,1431.4,1.30699082700301,0.3862490157441283,0.09151473289106439,1.0385089835485668,0.32644274411946783,0.4861929800657888,2049]
["O00115","Deoxyribonuclease-2-alpha [OS=Homo sapiens]",10,4,11,4,360,39.6,8.05,21.95,"cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes","other cytoplasmic organelle","nucleic acid binding activity;other molecular function","DNASE2","ENSG00000105612","Lysosome","Lysosome Vesicle Biogenesis","",1475.2,1266.4,1182.5,1199.4,1293.7,1838.2,0.9059866552767069,-0.1424382946245773,0.5660289731243245,0.24716133816513008,0.694611444688665,0.15825806536129558,5956]
["O00116","Alkyldihydroxyacetonephosphate synthase, peroxisomal [OS=Homo sapiens]",36,17,47,17,658,72.9,7.34,166.8,"other metabolic processes","cytosol;nucleus;other cytoplasmic organelle","other molecular function","AGPS","ENSG00000018510","Ether lipid metabolism; Metabolic pathways; Peroxisome","Plasmalogen biosynthesis; TYSND1 cleaves peroxisomal proteins","Triacylglyceride synthesis",4456.7,4389.9,4595.3,4356.3,4094.6,5517,0.9623422275359931,-0.055378059344587394,0.7114026175765691,0.14788454117867744,0.7996988206501298,0.09707354445481234,6502]
["O00124-1","UBX domain-containing protein 8 [OS=Homo sapiens]",8,1,1,1,270,30.5,7.78,3.78,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","UBXN8","ENSG00000104691; ENSPTRG00000049759","Protein processing in endoplasmic reticulum","","",13.8,12.4,12.9,20.3,12.5,31.2,0.6109375,-0.71090329758001,0.20166125663880904,0.6953775308610508,0.4485520769242408,0.34818712807612073,3286]
["O00139","Kinesin-like protein KIF2A [OS=Homo sapiens]",38,19,40,1,706,79.9,6.68,110.76,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KIF2A","ENSG00000068796","","COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Kinesins; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",3597.4,3585.2,3523.9,3818.6,3718.5,4630,0.8799549605082558,-0.1844984119491024,0.16790388889266233,0.7749392448681164,0.42013335293271786,0.37661283995769324,2921]
["O00139-2","Isoform 2 of Kinesin-like protein KIF2A [OS=Homo sapiens]",39,19,42,1,660,75,6.4,112.68,"","","","KIF2A","","","","",149.6,171.1,180.8,167.5,193,471.5,{"$f":"AVERAGE(S66:U66)/AVERAGE(V66:X66)","v":0.6027644230769231},{"$f":"LOG(Y66,2)","v":-0.7303338275289114},{"$f":"TTEST(S66:U66,V66:X66,2,2)","v":0.32296990107463386},{"$f":"-LOG10(AA66)","v":0.49083794951498605},{"$f":"AA66*7309/AE66","v":0.5391930120955913},{"$f":"-LOG10(AC66)","v":0.26825574486292597},4378]
["O00142","thymidine kinase 2, mitochondrial [OS=Homo sapiens]",15,3,5,3,265,31,8.46,13.08,"DNA metabolism;other metabolic processes","mitochondrion;other cell component","kinase activity;other molecular function","TK2","ENSG00000166548","Pyrimidine metabolism; Drug metabolism; Metabolic pathways","Pyrimidine salvage","Pyrimidine metabolism",502.8,479,469.2,454.1,439.1,490.1,1.0489409383358634,0.06893344782102302,0.2810751836269345,0.5511774969384563,0.5148818338669835,0.2882924307412316,3990]
["O00148","ATP-dependent RNA helicase DDX39A [OS=Homo sapiens]",56,22,194,9,427,49.1,5.68,472.72,"RNA metabolism OR transcription;other metabolic processes;transport","nucleus;other cell component","other molecular function","DDX39A","ENSG00000123136","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","",24448,24338.5,24255.7,25702.3,23819.2,21174.1,1.033193013426578,0.04710979292694424,0.5838398826662756,0.2337062412591511,0.7052199144617102,0.15167543230760605,6051]
["O00151","PDZ and LIM domain protein 1 [OS=Homo sapiens]",73,16,96,16,329,36,7.02,326.94,"cell organization and biogenesis;stress response;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","PDLIM1","ENSG00000107438","","","",11506.4,11372.1,11617.8,12502.6,13141.8,10253.8,0.9609479026803575,-0.057469876772885155,0.6230106375794479,0.20550453792732462,0.7331484060647536,0.13480810528890236,6211]
["O00154","cytosolic acyl coenzyme A thioester hydrolase [OS=Homo sapiens]",39,14,70,14,380,41.8,8.54,221.44,"other metabolic processes","cytosol;mitochondrion;nucleus","other molecular function","ACOT7","ENSG00000097021","Fatty acid elongation; Biosynthesis of unsaturated fatty acids","Mitochondrial Fatty Acid Beta-Oxidation","",6368.7,6271.2,6415.1,5621.5,5603.7,6431.7,1.079181509778047,0.10993753510745377,0.16700399973582564,0.7772731274009395,0.4197497366124998,0.37700956770396676,2908]
["O00159-1","Unconventional myosin-Ic [OS=Homo sapiens]",24,25,63,25,1063,121.6,9.41,176.7,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","MYO1C","ENSG00000197879","Pathogenic Escherichia coli infection","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Translocation of SLC2A4 (GLUT4) to the plasma membrane","VEGFA-VEGFR2 signaling pathway; Insulin signaling",8928.6,8694.3,8943.1,8970.4,8543.7,8856.5,1.007409766937423,0.010650623247786968,0.6882636804904609,0.1622451474573799,0.7827165459319712,0.10639548548380696,6427]
["O00161","Synaptosomal-associated protein 23 [OS=Homo sapiens]",57,11,42,11,211,23.3,5.01,126.62,"cell-cell signaling;cell organization and biogenesis;stress response;transport","plasma membrane;other membranes;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","SNAP23","ENSG00000092531","SNARE interactions in vesicular transport; Platelet activation","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; ER-Phagosome pathway; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; trans-Golgi Network Vesicle Budding","Insulin signaling",4310.9,4428.3,4386.9,3792.4,4336.9,4031.3,1.079395753499005,0.11022391666074914,0.11671990820099201,0.9328550626826162,0.3598084390725646,0.44392865477683136,2371]
["O00165","HCLS1-associated protein X-1 [OS=Homo sapiens]",45,10,25,10,279,31.6,4.92,86.17,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","HAX1","ENSG00000143575","","","",2612.6,2710.2,2704.5,2995.9,3300.3,4735.6,0.7276509726427236,-0.45868148619824406,0.13580261831376553,0.867091856651554,0.3833840622847865,0.416365945202453,2589]
["O00170","AH receptor-interacting protein [OS=Homo sapiens]",27,7,27,7,330,37.6,6.29,89.27,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","AIP","ENSG00000110711","Cushing syndrome; Chemical carcinogenesis","Aryl hydrocarbon receptor signalling; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","Aryl hydrocarbon receptor Netpath; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway",2895.2,2953,2775.3,3532,3435.6,3761.4,0.8037561748532016,-0.3151701789060339,0.003084431378237321,2.5108248874022947,0.06496861367013425,1.1872964003091955,347]
["O00178","GTP-binding protein 1 [OS=Homo sapiens]",34,16,39,16,669,72.4,8.34,131.59,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;other cytoplasmic organelle","nucleic acid binding activity;other molecular function","GTPBP1","ENSG00000100226","","","",3251.5,3196.7,3338.8,3173.6,3308.3,3119.7,1.0193092817863691,0.027591864652931827,0.42533259284495484,0.371271336424558,0.5930476766699304,0.22691039115116668,5242]
["O00186","syntaxin-binding protein 3 [OS=Homo sapiens]",19,9,24,9,592,67.7,7.8,66.92,"cell adhesion;cell-cell signaling;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","STXBP3","ENSG00000116266","","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Disinhibition of SNARE formation","Insulin signaling",2358.6,2252.7,2348.5,2164.9,2140.5,2261.8,1.0597819466439273,0.0837674564331973,0.05931176448691551,1.22685915579246,0.2644964531024195,0.577580147478986,1639]
["O00189","AP-4 complex subunit mu-1 [OS=Homo sapiens]",7,3,3,3,453,49.9,7.2,9.07,"transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","AP4M1","ENSG00000221838","Lysosome","Lysosome Vesicle Biogenesis","",210.6,234.2,214.1,210,207.8,360.2,0.8469151670951157,-0.2397106284474713,0.47955536873174043,0.3191612426196266,0.6323417265127712,0.19904815932811487,5543]
["O00193","Small acidic protein [OS=Homo sapiens]",33,6,29,6,183,20.3,4.72,110.48,"","","","SMAP","ENSG00000110696","","","",2890.5,2827.1,3197.2,3074.4,3436.3,3777.8,0.8664819944598338,-0.20675832446718112,0.12085811638732488,0.9177241786542142,0.36517237398716723,0.43750208513212097,2419]
["O00203-1","AP-3 complex subunit beta-1 [OS=Homo sapiens]",36,36,116,35,1094,121.2,6.04,322.39,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","AP3B1","ENSG00000132842","Lysosome","Golgi Associated Vesicle Biogenesis; Signaling by BRAF and RAF1 fusions","",16524.2,16365.1,16772.7,15594.9,15066.6,11748.1,1.1710084509167735,0.2277514874973058,0.11633811467617651,0.9342779784641384,0.35969343492731565,0.4440674887893831,2364]
["O00214-1","Galectin-8 [OS=Homo sapiens]",10,3,6,3,317,35.8,8.25,21.56,"other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;cytosol;other cell component","signal transduction activity or receptor binding;other molecular function","LGALS8","ENSG00000116977","","","",405.9,389.5,396.9,443.3,400.6,1220.6,0.5775248244126907,-0.7920451340082734,0.3366836942345751,0.472777916208956,0.5461209767333576,0.26271114171279514,4506]
["O00217","NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [OS=Homo sapiens]",31,6,19,6,210,23.7,6.34,49.75,"cell organization and biogenesis;other metabolic processes;stress response;transport","other membranes;mitochondrion","transporter activity;other molecular function","NDUFS8","ENSG00000110717","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",2154.4,2173.4,2084.7,2671.5,2675.8,2494.1,0.817774887137501,-0.2902243347358211,1.9169081526002607E-3,2.717398695559335,0.04968326839487697,1.3037898419947236,282]
["O00221","NF-kappa-B inhibitor epsilon [OS=Homo sapiens]",22,7,15,7,500,52.8,6.68,46.7,"other biological processes","cytosol;nucleus;other cell component","","NFKBIE","ENSG00000146232","Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; Neurotrophin signaling pathway; Adipocytokine signaling pathway; Epstein-Barr virus infection; PD-L1 expression and PD-1 checkpoint pathway in cancer","Activation of NF-kappaB in B cells","TNF-alpha signaling pathway; Apoptosis; Oxidative damage response; Canonical NF-kB pathway; IL-18 signaling pathway; STING pathway in Kawasaki-like disease and COVID-19",1287.9,1326.3,1340.8,1579.3,1686.8,5556.6,0.4482754712276287,-1.1575425348394048,0.2826813361820277,0.5487028645233333,0.515627124071485,0.2876642450720601,4007]
["O00231","26S proteasome non-ATPase regulatory subunit 11 [OS=Homo sapiens]",69,27,96,26,422,47.4,6.48,321.34,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","PSMD11","ENSG00000108671","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection","Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling pathway",15555.8,15158.8,14869.6,17054.6,15760.9,19822.4,0.8659957939051519,-0.20756807701032182,0.12491357159536919,0.9033903738854417,0.36858833055734896,0.43345841858730577,2477]
["O00232-1","26s proteasome non-atpase regulatory subunit 12 [OS=Homo sapiens]",61,28,163,28,456,52.9,7.65,457.29,"protein metabolism;other metabolic processes","non-structural extracellular;cytosol;nucleus;other cell component","","PSMD12","ENSCANG00000030312; ENSCATG00000032968; ENSCSAG00000004164; ENSG00000197170; ENSMFAG00000032701; ENSMLEG00000034943; ENSMMUG00000002132; ENSMNEG00000032475; ENSNLEG00000001265; ENSPANG00000020562; ENSPPYG00000008565; ENSRROG00000042400","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection","Activation of NF-kappaB in B cells; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease",15542.6,15756.4,15429,15355.9,13956.8,11641,1.1409958074606203,0.19029349051626657,0.15144900629032543,0.8197335718791221,0.40340407688629326,0.3942597170298632,2744]
["O00233-1","26S proteasome non-ATPase regulatory subunit 9 [OS=Homo sapiens]",30,6,24,6,223,24.7,6.95,72.5,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PSMD9","ENSG00000110801","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease",2114.7,2180.3,2306.9,2237.1,2323,2075.8,0.9948763543754426,-7.410859697253685E-3,0.9077261694396269,0.042045143810522684,0.938942905807279,0.02736081502537638,7066]
["O00244","Copper transport protein ATOX1 [OS=Homo sapiens]",40,3,9,3,68,7.4,7.24,33.66,"stress response;transport;other biological processes","cytosol","other molecular function","ATOX1","ENSG00000177556","Mineral absorption","Detoxification of Reactive Oxygen Species; Ion influx/efflux at host-pathogen interface","Copper homeostasis",1097.9,1091.1,1164.9,1138.8,1217.3,991.6,1.0018520178032682,0.002669425750704093,0.9779301248595466,0.009692175347420623,0.9854806676683339,6.351890925193982E-3,7253]
["O00255-1","Menin [OS=Homo sapiens]",23,10,17,10,615,68,6.55,59.91,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","MEN1","ENSG00000133895","Cushing syndrome; Transcriptional misregulation in cancer","RHO GTPases activate IQGAPs; Formation of the beta-catenin:TCF transactivating complex; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",1381.2,1344.1,1381,1427.1,1456.8,1922,0.8544289311055162,-0.2269675971411476,0.2204100832203021,0.6567685414592306,0.46466031100582295,0.3328644212316543,3467]
["O00257-1","E3 SUMO-protein ligase CBX4 [OS=Homo sapiens]",5,2,3,2,560,61.3,9.36,8.25,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","CBX4","ENSG00000141582; ENSPTRG00000040905","","SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Oxidative Stress Induced Senescence; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN gene transcription","",199.9,209.7,189.3,201.9,223.2,266,0.8665894950079583,-0.20657934684414178,0.19460737802175232,0.7108406986339896,0.44173457327980986,0.35483860844584747,3220]
["O00258-1","Tail-anchored protein insertion receptor WRB [OS=Homo sapiens]",12,2,3,2,174,19.8,9.67,7.23,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;ER/Golgi;nucleus","","GET1; WRB","ENSANAG00000014374; ENSCANG00000035340; ENSCATG00000041953; ENSCCAG00000026562; ENSCSAG00000008355; ENSG00000182093; ENSMLEG00000038301; ENSMNEG00000036276; ENSNLEG00000033928; ENSPANG00000032093; ENSPPAG00000034665; ENSPPYG00000011427; ENSPTRG00000013915; ENSSBOG00000020756","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",350.3,404,398.8,346.9,358.3,271.4,1.1807290600040956,0.23967794980469218,0.14155261062900906,0.8490821166110096,0.3913040964778469,0.40748560554063923,2644]
["O00264","Membrane-associated progesterone receptor component 1 [OS=Homo sapiens]",61,12,49,10,195,21.7,4.7,143.13,"other metabolic processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","PGRMC1","ENSG00000101856","","Neutrophil degranulation","",3352.8,3757.6,3317.9,3056.2,3665.6,2840.3,1.0905867957875364,0.12510459333420965,0.36764755474382554,0.43456831821337505,0.5609887218418833,0.2510458697439653,4790]
["O00267","Transcription elongation factor Spt5 [OS=Homo sapiens]",35,32,126,32,1087,120.9,5.06,422.29,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","SUPT5H","ENSG00000196235","","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE","Initiation of transcription and translation elongation at the HIV-1 LTR; mRNA processing",10972,11184.1,11215,10375.5,10216.4,9399.7,1.1126815508342334,0.15404075281498736,0.02248923934184657,1.6480252335472636,0.17248043058715276,0.7632601723016171,953]
["O00268","Transcription initiation factor TFIID subunit 4 [OS=Homo sapiens]",8,6,7,6,1085,110,9.94,21.59,"RNA metabolism OR transcription;other metabolic processes;developmental processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","TAF4","ENSG00000130699","Basal transcription factors; Huntington disease","RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation","",659.6,619.7,628.7,777.7,756.3,749.8,0.8354496891146336,-0.2593751432618969,0.00104907777148034,2.9791923149782447,0.03616844071580096,1.4416702140230233,212]
["O00273-1","DNA fragmentation factor subunit alpha [OS=Homo sapiens]",50,11,30,3,331,36.5,4.79,101.46,"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","DFFA","ENSG00000160049","Apoptosis","Apoptosis induced DNA fragmentation","Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis",3120.2,3236.3,3066.6,3664.1,3806.5,5204,0.7434633045618796,-0.42766655857211267,0.09319938461168503,1.0305869552493638,0.32923842538753306,0.48248948403112535,2069]
["O00273-2","Isoform DFF35 of DNA fragmentation factor subunit alpha [OS=Homo sapiens]",55,9,25,1,268,29.4,4.61,92.3,"","","","DFFA","","","","",78.8,69.2,75.1,90.3,72.7,135,0.7486577181208054,-0.4176218171053834,0.25387327876403326,0.5953830080512096,0.4942887039121788,0.30601931445256414,3754]
["O00287","Regulatory factor X-associated protein [OS=Homo sapiens]",7,1,1,1,272,28.2,5.54,2.31,"other biological processes","nucleus","nucleic acid binding activity","RFXAP","ENSG00000133111","Antigen processing and presentation; Tuberculosis; Primary immunodeficiency","","",10.2,13.2,14,12.7,11.1,3.2,1.3851851851851855,0.47007886283680617,0.3337062406160845,0.47663567155981085,0.5444327930051254,0.2640557236739819,4480]
["O00291","Huntingtin-interacting protein 1 [OS=Homo sapiens]",4,3,3,2,1037,116.1,5.3,7.67,"cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","HIP1","ENSG00000127946","Huntington disease; Pathways of neurodegeneration","Clathrin-mediated endocytosis; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants","",87.2,87,84,94.5,91.5,141.6,0.7881562881562881,-0.343446356333818,0.22780589504063425,0.6424350416682783,0.4718144762969668,0.3262287381442745,3529]
["O00299","chloride intracellular channel protein 1 [OS=Homo sapiens]",86,18,273,17,241,26.9,5.17,1010.2,"other metabolic processes;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;mitochondrion;nucleus;other cell component","transporter activity","CLIC1","ENSG00000206394; ENSG00000213719; ENSG00000223639; ENSG00000226248; ENSG00000226417; ENSG00000226651; ENSG00000230685","","","VEGFA-VEGFR2 signaling pathway",30621.5,30782.4,29610.9,29428.6,30336.2,19887.3,1.1426541170917024,0.19238876394309348,0.3229354222738072,0.4908843152977551,0.5392586249484252,0.2682029000268961,4377]
["O00300","Tumor necrosis factor receptor superfamily member 11B [OS=Homo sapiens]",2,1,1,1,401,46,8.29,2.56,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","TNFRSF11B","ENSG00000164761","Cytokine-cytokine receptor interaction; Osteoclast differentiation","TNFs bind their physiological receptors","Osteoclast signaling; RANKL/RANK signaling pathway; Ectoderm differentiation; Vitamin D receptor pathway; Osteoblast signaling; IL-18 signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta; Overlap between signal transduction pathways contributing to LMNA laminopathies; Monoamine transport",175.8,169.8,167.6,149.9,131.5,138,1.2236528373867432,0.29119430899309023,0.006157878924982003,2.210568854362528,0.08894849221876178,1.0508614093183546,506]
["O00303","Eukaryotic translation initiation factor 3 subunit F [OS=Homo sapiens]",47,12,71,12,357,37.5,5.45,236.86,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3F","ENSG00000175390","","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","Translation factors; VEGFA-VEGFR2 signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell",7106.3,7047.5,7241.2,7458,7639.6,7674.9,0.9395103743550336,-0.09001900248319825,6.5242073493500825E-3,2.1854722448654256,0.09117673330095555,1.040115971848727,523]
["O00308","NEDD4-like E3 ubiquitin-protein ligase WWP2 [OS=Homo sapiens]",9,6,6,6,870,98.9,7.12,10.1,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","WWP2","ENSG00000198373","Ubiquitin mediated proteolysis","RHOQ GTPase cycle; Regulation of PTEN stability and activity; RHOJ GTPase cycle; NOTCH3 Activation and Transmission of Signal to the Nucleus; RHOU GTPase cycle","",595.4,617.9,622.9,781,766,837.9,0.7699274602708708,-0.3772055680893346,1.4638522045552916E-3,2.834502768896639,0.04349307220770174,1.3615799141160447,246]
["O00327-1","Isoform BMAL1A of Aryl hydrocarbon receptor nuclear translocator-like protein 1 [OS=Homo sapiens]",2,1,1,1,583,64.2,6.98,2.86,"","","","ARNTL","","","","",36.7,34.7,34.5,40.7,36.4,23.8,1.049554013875124,0.06977641488597944,0.7610743055091422,0.11857293994792598,0.8363692826591972,0.07760192589810364,6651]
["O00330-1","Pyruvate dehydrogenase protein X component, mitochondrial [OS=Homo sapiens]",29,14,42,14,501,54.1,8.66,119.68,"other metabolic processes","mitochondrion;other cell component","other molecular function","PDHX","ENSG00000110435","Metabolic pathways","Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid","Amino acid metabolism",6301.1,6290,6393.6,6065,5880.9,8357.9,0.9350318659561264,-0.09691256189405204,0.6107160183869514,0.21416068880415393,0.7233387422444059,0.14065827333456735,6171]
["O00391","Sulfhydryl oxidase 1 [OS=Homo sapiens]",2,1,1,1,747,82.5,8.92,2.8,"cell organization and biogenesis;other biological processes","non-structural extracellular;other membranes;ER/Golgi;other cell component","other molecular function","QSOX1","ENSG00000116260","","Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",35.5,31.9,22.1,30.1,23.5,11.5,1.3748079877112136,0.4592301389859834,0.2951351437782463,0.529979072979847,0.5238326289157849,0.28080745337788665,4118]
["O00399","Dynactin subunit 6 [OS=Homo sapiens]",22,4,9,4,190,20.7,6.32,21.9,"cell cycle OR cell proliferation;cell organization and biogenesis","cytosol;cytoskeleton;other cell component","other molecular function","DCTN6","ENSG00000104671","Vasopressin-regulated water reabsorption; Amyotrophic lateral sclerosis; Huntington disease; Pathways of neurodegeneration; Salmonella infection","MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic","",1096,1025,1066.3,1212.3,1218,2029.8,0.7146252326181027,-0.48474124011569936,0.1942575800894775,0.7116220256709169,0.44190123027512945,0.3546747893384621,3213]
["O00400","Acetyl-coenzyme A transporter 1 [OS=Homo sapiens]",23,12,40,12,549,60.9,7.33,119.98,"transport;signal transduction","plasma membrane;other membranes;ER/Golgi","transporter activity","SLC33A1","ENSG00000169359","Glycosphingolipid biosynthesis; Metabolic pathways","Transport of vitamins, nucleosides, and related molecules; Defective SLC33A1 causes spastic paraplegia 42 (SPG42)","Ganglio sphingolipid metabolism",4179.3,4200.5,4542,4236.2,3712.8,4514.2,1.0367963283907822,0.05213251432496142,0.5918340655486956,0.2278000407738423,0.711115434012069,0.14805989535279263,6083]
["O00401","Neural Wiskott-Aldrich syndrome protein [OS=Homo sapiens]",2,1,1,1,505,54.8,7.93,1.92,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity","WASL","ENSG00000106299","Endocytosis; Adherens junction; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection","Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RHOJ GTPase cycle; RHOV GTPase cycle; NOSTRIN mediated eNOS trafficking; Nephrin family interactions; EPHB-mediated forward signaling; DCC mediated attractive signaling","Pathogenic Escherichia coli infection; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Chemokine signaling pathway; G13 signaling pathway",144.9,165.6,153.3,144.1,145.7,92,1.214772132006286,0.28068571724206604,0.21633810053039593,0.6648669877595069,0.462343618940545,0.335035131931669,3420]
["O00410","Importin-5 [OS=Homo sapiens]",59,46,321,43,1097,123.6,4.94,1059.57,"transport;other biological processes","nucleus;other cell component","enzyme regulator activity;other molecular function","IPO5","ENSG00000065150","Nucleocytoplasmic transport","vRNP Assembly","",32500.8,32630.1,32678.4,32169.4,31506.5,24107.6,1.114210529313595,0.15602185467087892,0.2656024173119492,0.575767976666734,0.502403744340848,0.29894713252621674,3864]
["O00411","DNA-directed RNA polymerase, mitochondrial [OS=Homo sapiens]",19,16,52,16,1230,138.5,8.98,169.38,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","POLRMT","ENSG00000099821","","Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis","Mitochondrial gene expression",2867.5,2788.7,2827.7,3221.2,3059.9,4222.6,0.807705856031684,-0.30809809560468715,0.13836290981713079,0.8589803132070043,0.38717247620727757,0.4120955239260676,2612]
["O00418","Eukaryotic elongation factor 2 kinase [OS=Homo sapiens]",16,11,19,11,725,82.1,5.33,36.59,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;other cell component","nucleic acid binding activity;kinase activity;other molecular function","EEF2K","ENSG00000103319","AMPK signaling pathway; Oxytocin signaling pathway","mTORC1-mediated signalling","Translation factors; AMP-activated protein kinase (AMPK) signaling; BDNF-TrkB signaling",1563,1488.5,1524.6,1695.3,1608.5,2592.4,0.7761100369729655,-0.36566688249957596,0.23524023179315015,0.628488401339221,0.4774703843865966,0.32105356082653336,3601]
["O00422","Histone deacetylase complex subunit SAP18 [OS=Homo sapiens]",52,8,41,8,153,17.6,9.35,77,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","SAP18","ENSG00000150459","Nucleocytoplasmic transport; mRNA surveillance pathway","Potential therapeutics for SARS; HDACs deacetylate histones; NoRC negatively regulates rRNA expression","Hedgehog signaling pathway Netpath",4616,4644.1,4574.7,4930.1,5002.2,4738.1,0.9430417711855164,-0.0846064196948088,0.02668550087087417,1.5737246413364898,0.1859335804244226,0.7306421676460748,1049]
["O00425","Insulin-like growth factor 2 mRNA-binding protein 3 [OS=Homo sapiens]",2,2,2,2,579,63.7,8.87,2.02,"protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","IGF2BP3","ENSG00000136231","","Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA","",150.9,134.6,142.6,160.9,155.1,86.3,1.0641312453392993,0.08967609757128983,0.7424449286264301,0.12933575491400612,0.8230744703974787,0.08456086877373584,6593]
["O00429","Dynamin-1-like protein [OS=Homo sapiens]",70,45,189,1,736,81.8,6.81,589.96,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","DNM1L","ENSG00000087470","Necroptosis; NOD-like receptor signaling pathway; TNF signaling pathway","Apoptotic execution phase","Synaptic vesicle pathway; CAMKK2 pathway",19974.2,19745.1,19464.9,18290.6,17781.6,15240.3,1.1534070645554202,0.20590176396324386,0.051484824702571375,1.2883207616215349,0.24789366518517403,0.6057345712970235,1518]
["O00429-2","Isoform 4 of Dynamin-1-like protein [OS=Homo sapiens]",71,45,192,1,725,80.5,6.71,609.4,"","","","DNM1L","","","","",364,400,369.6,402.7,419.6,447.6,0.892668714071974,-0.16380323112155826,0.05767098343823731,1.2390426426907475,0.2610013733437006,0.5833572074738962,1615]
["O00442","RNA 3'-terminal phosphate cyclase [OS=Homo sapiens]",44,14,51,14,366,39.3,7.85,155.6,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","RTCA","ENSG00000137996","","","",4487.3,4357.4,4334.4,4173.4,3915.1,3798.1,1.1087358874699242,0.1489157413184649,0.023359579806237905,1.6315349736090174,0.1760156379420545,0.7544487459912893,970]
["O00443","phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [OS=Homo sapiens]",16,23,31,23,1686,190.6,8.02,87.31,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","PIK3C2A","ENSG00000011405","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Salmonella infection","Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane","Glioblastoma signaling pathways; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; Osteoblast differentiation and related diseases; Insulin signaling; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)",2345.4,2429.3,2397.1,2998.7,3003.3,3676.6,0.7409955985369785,-0.4324631218403733,0.021041556995464526,1.676922127183695,0.16771291175556186,0.7754335009697432,917]
["O00459","Phosphatidylinositol 3-kinase regulatory subunit beta [OS=Homo sapiens]",6,3,5,3,728,81.5,6.43,10.37,"other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;cytosol;nucleus","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","PIK3R2","ENSG00000105647","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; Platinum drug resistance; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Phosphatidylinositol signaling system; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Osteoclast differentiation; Focal adhesion; Signaling pathways regulating pluripotency of stem cells; Platelet activation; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; TNF signaling pathway; Leukocyte transendothelial migration; Neurotrophin signaling pathway; Cholinergic synapse; Inflammatory mediator regulation of TRP channels; Regulation of actin cytoskeleton; Insulin signaling pathway; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Prolactin signaling pathway; Thyroid hormone signaling pathway; Regulation of lipolysis in adipocytes; Relaxin signaling pathway; GnRH secretion; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Aldosterone-regulated sodium reabsorption; Carbohydrate digestion and absorption; Alzheimer disease; Spinocerebellar ataxia; Prion disease; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection; Chagas disease; Amoebiasis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","Downstream TCR signaling; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOJ GTPase cycle; Nephrin family interactions; Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; RND2 GTPase cycle; RHOA GTPase cycle; G alpha (q) signalling events; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; Extra-nuclear estrogen signaling; RHOU GTPase cycle; PIP3 activates AKT signaling; Synthesis of PIPs at the plasma membrane; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Interleukin receptor SHC signaling; Regulation of signaling by CBL; RAF/MAP kinase cascade; PI3K Cascade; GPVI-mediated activation cascade; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; Costimulation by the CD28 family; CD28 dependent PI3K/Akt signaling; VEGFA-VEGFR2 Pathway; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; RND3 GTPase cycle; RND1 GTPase cycle","IL-5 signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase (AMPK) signaling; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL-6 signaling pathway; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Ebola virus pathway in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Modulators of TCR signaling and T cell activation; Orexin receptor pathway; Regulation of actin cytoskeleton; Alzheimer's disease; G13 signaling pathway; Interferon type I signaling pathways; Notch signaling pathway (Netpath); ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway",221.5,223.8,232.7,288,282.3,380.6,0.713008728572931,-0.4880083567991216,0.04691474446587403,1.3286906448367535,0.23583209580541492,0.6273970894757995,1454]
["O00461","Golgi integral membrane protein 4 [OS=Homo sapiens]",38,23,53,23,696,81.8,4.77,156.08,"","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","GOLIM4","ENSG00000173905","","Intra-Golgi traffic","",3701.9,3832.1,3902.4,4137.1,4307.5,3796.1,0.9342929734410613,-0.09805307701511076,0.1720466868585632,0.7643536862682652,0.42268545689050036,0.37398269444886056,2975]
["O00462","Beta-mannosidase [OS=Homo sapiens]",14,11,21,10,879,100.8,5.52,57.12,"protein metabolism;other metabolic processes","plasma membrane;other membranes;other cytoplasmic organelle","other molecular function","MANBA","ENSG00000109323","Other glycan degradation; Lysosome","Neutrophil degranulation; Lysosomal oligosaccharide catabolism","",1305,1389.5,1470.7,1318.6,1323.4,1890.2,0.9190238736154626,-0.12182575578951048,0.5657467089504679,0.24737796373436272,0.6944982693515233,0.15832883216109572,5954]
["O00463","TNF receptor-associated factor 5 [OS=Homo sapiens]",2,1,3,1,557,64.4,7.43,5.82,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton","signal transduction activity or receptor binding;other molecular function","TRAF5","ENSG00000082512","NF-kappa B signaling pathway; Necroptosis; NOD-like receptor signaling pathway; IL-17 signaling pathway; TNF signaling pathway; Shigellosis; Human cytomegalovirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Viral carcinogenesis; Small cell lung cancer","","RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Small cell lung cancer; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling",31.9,27,27.3,38.9,36.8,20,0.9007314524555906,-0.15083105539692707,0.6357579669022109,0.19670818882431196,0.7431240972474427,0.12893865562100756,6253]
["O00469-1","procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 [OS=Homo sapiens]",4,2,2,2,737,84.6,6.71,7.23,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","other molecular function","PLOD2","ENSG00000152952","Lysine degradation; Metabolic pathways","Collagen biosynthesis and modifying enzymes","Clear cell renal cell carcinoma pathways; Type I collagen synthesis in the context of osteogenesis imperfecta",155.4,193.4,172.3,213.1,233.8,283.6,0.713347022587269,-0.4873240182593117,0.0418253133440652,1.3785607967352342,0.22313957316187777,0.6514234020076681,1370]
["O00470","Homeobox protein Meis1 [OS=Homo sapiens]",2,1,1,1,390,43,6.33,2.92,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MEIS1","ENSG00000143995","Signaling pathways regulating pluripotency of stem cells; Transcriptional misregulation in cancer","Activation of anterior HOX genes in hindbrain development during early embryogenesis","Mesodermal commitment pathway",28.7,30.1,33.3,53,61.9,52.2,0.5511669658886893,-0.8594386719698527,1.8092235158189134E-3,2.7425077760421814,0.0475669592702174,1.3226946100762849,278]
["O00471","Exocyst complex component 5 [OS=Homo sapiens]",21,14,26,14,708,81.8,6.71,63.68,"cell organization and biogenesis;transport;other biological processes","cytosol;other cell component","other molecular function","EXOC5","ENSG00000070367","Salmonella infection","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium","Ciliary landscape",2135.3,2088.4,2065.3,2119.4,2100,3453.2,0.8196699945259757,-0.2868849084349336,0.36176376310161107,0.44157493740206455,0.5578336169851635,0.25349531719217666,4740]
["O00479","High mobility group nucleosome-binding domain-containing protein 4 [OS=Homo sapiens]",27,3,5,3,90,9.5,10.48,8.92,"cell organization and biogenesis","nucleus;other cell component","nucleic acid binding activity;other molecular function","HMGN4","ENSG00000182952","","","",606.4,649.4,786.2,575.9,683.9,539,1.1352012452746274,0.18294807709614794,0.30816638312142447,0.5112147388205465,0.5322278105469025,0.27390243596370284,4232]
["O00481-1","Butyrophilin subfamily 3 member A1 [OS=Homo sapiens]",10,5,6,2,513,57.6,8.03,14.04,"cell cycle OR cell proliferation;signal transduction;other biological processes","plasma membrane;other membranes","signal transduction activity or receptor binding","BTN3A1","ENSG00000026950","","Butyrophilin (BTN) family interactions","",223.3,273.2,238.8,230.2,211.3,212.8,1.123796423658872,0.168380714226089,0.16562748904616245,0.7808675821024162,0.41815934971965507,0.3786581882818983,2895]
["O00483","Cytochrome c oxidase subunit NDUFA4 [OS=Homo sapiens]",56,5,23,5,81,9.4,9.38,59.42,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","NDUFA4","ENSG00000189043","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; Oxidative phosphorylation",4434.6,4704,4704.6,4209.6,5351,2755.8,1.1239647949076028,0.16859684782962314,0.537891010765658,0.269305713586704,0.6744630979046482,0.17104180702217606,5829]
["O00487","26S proteasome non-ATPase regulatory subunit 14 [OS=Homo sapiens]",47,12,47,12,310,34.6,6.52,121.33,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PSMD14","ENSG00000115233","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection","Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; Metalloprotease DUBs","Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease",5802.5,5729.2,5596.1,5230.7,5249.7,4488.4,1.1442333386777834,0.19438128483178854,0.04925316589305385,1.307565848705582,0.24356656935881635,0.6133823208804158,1478]
["O00499","Myc box-dependent-interacting protein 1 [OS=Homo sapiens]",4,2,6,1,593,64.7,5.06,19.85,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","BIN1","ENSG00000136717","Endocytosis; Fc gamma R-mediated phagocytosis","Clathrin-mediated endocytosis","VEGFA-VEGFR2 signaling pathway; IL-18 signaling pathway",48.6,38.1,38.3,58.4,55.3,50.5,0.7612667478684532,-0.39352603222835525,0.03480306019497234,1.4583825673362227,0.20782317562504316,0.6823060232617922,1224]
["O00505","Importin subunit alpha-4 [OS=Homo sapiens]",28,11,49,7,521,57.8,4.94,140.19,"cell organization and biogenesis;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","KPNA3","ENSG00000102753","Nucleocytoplasmic transport; Salmonella infection; Chemical carcinogenesis","ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways","",1025.1,1034.4,1050.3,1016,1092.6,662.2,1.1223473365093115,0.16651922061058425,0.4426397798329454,0.35394955880999085,0.6051728677139914,0.21812055134653632,5346]
["O00506","serine/threonine-protein kinase 25 [OS=Homo sapiens]",23,7,35,2,426,48.1,6.74,85.36,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","kinase activity;other molecular function","STK25","ENSG00000115694","","","",64.7,62,79.4,65.7,75,246.5,0.5322830578512397,-0.9097344477353381,0.364261009577646,0.4385873130608919,0.5592068302883879,0.25242753265142953,4761]
["O00507-1","Probable ubiquitin carboxyl-terminal hydrolase FAF-Y [OS=Homo sapiens]",9,21,47,1,2555,290.9,5.86,131.75,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","USP9Y","ENSG00000114374","","","",153.5,112.5,139.6,115,132.6,181.1,{"$f":"AVERAGE(S130:U130)/AVERAGE(V130:X130)","v":0.9461161651504549},{"$f":"LOG(Y130,2)","v":-0.07991076481363203},{"$f":"TTEST(S130:U130,V130:X130,2,2)","v":0.7560456649574747},{"$f":"-LOG10(AA130)","v":0.1214519724351551},{"$f":"AA130*7309/AE130","v":0.8329722286967414},{"$f":"-LOG10(AC130)","v":0.07936947773464569},6634]
["O00512","B-cell CLL/lymphoma 9 protein [OS=Homo sapiens]",1,1,1,1,1426,149.2,8.91,0,"cell-cell signaling;developmental processes;signal transduction;other biological processes","ER/Golgi;nucleus","other molecular function","BCL9","ENSG00000116128","","Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex","Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; 1q21.1 copy number variation syndrome",16.7,12,21,15.7,17.8,45,0.6331210191082802,-0.6594468022167033,0.3822054556571628,0.4177031180531395,0.5682546125708305,0.24545703038358296,4916]
["O00519","Fatty-acid amide hydrolase 1 [OS=Homo sapiens]",25,10,26,10,579,63,7.66,84.13,"other metabolic processes","other membranes;cytoskeleton;ER/Golgi","other molecular function","FAAH","ENSG00000117480","Retrograde endocannabinoid signaling","Arachidonic acid metabolism","Cannabinoid receptor signaling",2231.8,2187.6,2248.3,2007.5,2099.8,2778.6,0.9683120579735403,-0.04645603505341117,0.7802954650515157,0.10774091712499495,0.8495724048952076,0.0707996024259424,6713]
["O00522","Krev interaction trapped protein 1 [OS=Homo sapiens]",9,6,11,6,736,84.3,8.41,34.25,"developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","KRIT1","ENSG00000001631","Rap1 signaling pathway","","",924.2,1003.2,973.4,899.8,920,1279.5,0.9359532797728519,-0.09549157867085713,0.6258458485814604,0.20353262422504617,0.7358924239513986,0.13318566813393107,6216]
["O00534","von Willebrand factor A domain-containing protein 5A [OS=Homo sapiens]",5,4,4,4,786,86.4,6.58,7.8,"","nucleus","","VWA5A","ENSG00000110002","","","",448.7,453.8,487.2,451.6,417.8,420.5,1.0773703387859523,0.10751425182346368,0.1097092930923729,0.9597565832931341,0.35015948611884434,0.4557341037490491,2290]
["O00541-1","Pescadillo homolog [OS=Homo sapiens]",32,18,54,18,588,68,7.33,167.5,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PES1","ENSG00000100029","","Major pathway of rRNA processing in the nucleolus and cytosol","",6558.3,6561.4,6515.5,8828.2,8283.3,8207.2,0.7755216500057269,-0.36676103777826796,6.4240089128413916E-4,3.192193865177204,0.028983383422196134,1.537850917835862,162]
["O00555-1","Voltage-dependent P/Q-type calcium channel subunit alpha-1A [OS=Homo sapiens]",1,1,2,1,2505,282.2,8.84,2.07,"","","","","","","","",753.3,905.6,965.1,536.3,571.9,221.5,1.9733774535609536,0.9806669308705831,0.028003544561643893,1.552786994152977,0.18986818849819592,0.7215477931197241,1078]
["O00559","Receptor-binding cancer antigen expressed on SiSo cells [OS=Homo sapiens]",8,1,1,1,213,24.4,6.29,3.29,"other biological processes","other membranes;ER/Golgi;other cell component","enzyme regulator activity","EBAG9","ENSG00000147654","Estrogen signaling pathway","Estrogen-dependent gene expression","",38.6,44.7,34.1,42.6,51.4,74.3,0.6975638740344623,-0.5196027682198968,0.16285546998933034,0.7881976497715908,0.415031600471414,0.3819188348833803,2868]
["O00560-1","Syntenin-1 [OS=Homo sapiens]",23,4,13,4,298,32.4,7.53,47.62,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","SDCBP","ENSG00000137575; ENSPPAG00000038846; ENSPTRG00000020277","","Neutrophil degranulation; Ephrin signaling; Neurofascin interactions; Regulation of necroptotic cell death","Ectoderm differentiation; Ectoderm differentiation; VEGFA-VEGFR2 signaling pathway",1033.4,982,1043.1,813.2,835.5,1467.3,0.9815468549422336,-0.026870957323916544,0.9333272133666974,0.029966071102214716,0.9558201768946605,0.019623805975170414,7137]
["O00566","U3 small nucleolar ribonucleoprotein protein Mpp10 [OS=Homo sapiens]",27,15,32,15,681,78.8,4.86,83.9,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","MPHOSPH10","ENSG00000124383","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",2424.3,2477.5,2406.6,3835.5,3701,2119.3,0.7568922305764411,-0.40184019689726697,0.2289076940971909,0.6403396094757633,0.4727568059215508,0.3253622102293052,3539]
["O00567","Nucleolar protein 56 [OS=Homo sapiens]",67,29,161,29,594,66,9.19,489.84,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NOP56","ENSG00000101361","Ribosome biogenesis in eukaryotes; Spinocerebellar ataxia","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; Association of TriC/CCT with target proteins during biosynthesis","",17604.3,17508.2,17717.2,17149.4,16242.9,16429.3,1.0603774266583168,0.08457786351590656,0.02392234739593269,1.6211962071635126,0.17751110367195128,0.7507744757771514,985]
["O00571","ATP-dependent RNA helicase DDX3X [OS=Homo sapiens]",58,34,224,33,662,73.2,7.18,686.69,"cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function","DDX3X","ENSG00000215301","RIG-I-like receptor signaling pathway; Hepatitis B; Viral carcinogenesis","Neutrophil degranulation","Novel intracellular components of RIG-I-like receptor (RLR) pathway; Hepatitis B infection",27819.4,27775.9,28243.8,33554.5,33132.1,22239.6,0.9427941371609266,-0.08498530778332508,0.6710423671552419,0.173250059203773,0.770202365191216,0.11339515204941265,6368]
["O00592","Podocalyxin [OS=Homo sapiens]",13,7,19,7,558,58.6,5.49,54.88,"cell adhesion;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","","PODXL","ENSG00000128567","Salmonella infection","","Primary focal segmental glomerulosclerosis (FSGS); Ectoderm differentiation; Hepatitis C and hepatocellular carcinoma; Nephrotic syndrome; Malignant pleural mesothelioma",2930.5,3019.8,3036.3,2436.9,2684,2327.5,1.2065141506900812,0.2708448364079408,0.00971581484536352,2.012520770153766,0.11343912253156864,0.9452371414802226,626]
["O00625","Pirin [OS=Homo sapiens]",10,3,9,3,290,32.1,6.92,14.48,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PIR","ENSG00000087842","","Digestion","",1139.6,1101.2,1087.7,1135.8,1048.9,1355.1,0.9403073619978531,-0.0887956815552134,0.4884694226324927,0.31116261720132005,0.6381095639000696,0.19510474618171592,5595]
["O00629","Importin subunit alpha-3 [OS=Homo sapiens]",41,13,91,9,521,57.9,4.96,346.45,"transport","other membranes;cytosol;nucleus","other molecular function","KPNA4","ENSG00000186432","Nucleocytoplasmic transport; Salmonella infection; Chemical carcinogenesis","ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways","Leptin signaling pathway",10627.8,10396.3,10654,9700.6,10471,6426,1.191013474899991,0.25218973567173464,0.24464798580765892,0.611458355445511,0.4853778849805046,0.3139200150863493,3684]
["O00635","E3 ubiquitin-protein ligase TRIM38 [OS=Homo sapiens]",8,4,9,4,465,53.4,7.02,15.62,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","TRIM38","ENSG00000112343","","Interferon gamma signaling","",792.9,806.2,852.3,762.7,771.6,2036.2,0.6865705083321663,-0.5425202072932309,0.4280589989802979,0.36849636845012806,0.5944676465033246,0.2258717765834326,5263]
["O00743","Serine/threonine-protein phosphatase 6 catalytic subunit [OS=Homo sapiens]",33,9,31,9,305,35.1,5.69,93.67,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport","cytosol;mitochondrion;nucleus","other molecular function","PPP6C","ENSG00000119414","","Telomere Extension By Telomerase; COPII-mediated vesicle transport","",3836.5,3837,3692.5,3754.2,3731.2,3826,1.0048269887016639,0.00694711928559671,0.7611443766817702,0.11853295683118945,0.8363205425687099,0.07762723549469809,6652]
["O00746","Nucleoside diphosphate kinase, mitochondrial [OS=Homo sapiens]",16,2,4,2,187,20.6,10.29,10.56,"other metabolic processes;transport","other membranes;mitochondrion","kinase activity;other molecular function","NME4","ENSG00000103202","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors","Interconversion of nucleotide di- and triphosphates","Pyrimidine metabolism",406.7,409.3,427.1,361.1,418.5,419,1.037126647755715,0.05259207827136546,0.5046319478663811,0.2970252580933795,0.6489012855305031,0.18782136546483866,5684]
["O00750","Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [OS=Homo sapiens]",2,3,3,3,1634,184.7,7.3,8.8,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","PIK3C2B","ENSG00000133056","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Salmonella infection","Synthesis of PIPs at the plasma membrane","Glioblastoma signaling pathways; S1P receptor signal transduction; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; EGF/EGFR signaling pathway; Osteoblast differentiation and related diseases; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)",168.7,151.6,157,200.9,207.5,222.7,0.7562985263825068,-0.402972287000721,3.327075881227254E-3,2.477937293984658,0.06699062704101928,1.1739859571367974,363]
["O00754","Lysosomal alpha-mannosidase [OS=Homo sapiens]",11,10,16,10,1011,113.7,7.28,49.54,"protein metabolism;other metabolic processes","non-structural extracellular;other membranes;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MAN2B1","ENSG00000104774","Other glycan degradation; Lysosome","Neutrophil degranulation; Lysosomal oligosaccharide catabolism","",2048.7,2086.1,2064.9,1786.6,1800,4479.4,0.768621373667245,-0.37965499975778916,0.5254603310359346,0.2794600649116354,0.6653828065733968,0.17692842544911902,5772]
["O00762","Ubiquitin-conjugating enzyme E2 C [OS=Homo sapiens]",6,1,1,1,179,19.6,7.37,0,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","UBE2C","ENSG00000175063","Ubiquitin mediated proteolysis","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Gastric cancer network 1; Gastric cancer network 2",26.1,28.2,17.1,49.4,62.7,137.8,0.28571428571428575,-1.807354922057604,0.09844743945598243,1.0067955750525153,0.33389899535210005,0.47638488766529263,2155]
["O00763","Acetyl-CoA carboxylase 2 [OS=Homo sapiens]",5,9,16,5,2458,276.4,6.49,54.84,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus","other molecular function","ACACB","ENSG00000076555","Fatty acid biosynthesis; Pyruvate metabolism; Propanoate metabolism; Metabolic pathways; AMPK signaling pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Glucagon signaling pathway; Insulin resistance; Alcoholic liver disease","ChREBP activates metabolic gene expression; Biotin transport and metabolism; Carnitine metabolism; Activation of gene expression by SREBF (SREBP)","AMP-activated protein kinase (AMPK) signaling; Leptin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; IL-18 signaling pathway; 7q11.23 copy number variation syndrome",466.8,516.1,487.4,550.4,556.6,808,0.7677806788511751,-0.3812338395687689,0.16004699338002762,0.7957524800373622,0.41218586138640656,0.38490690927484444,2838]
["O00764-1","Pyridoxal kinase [OS=Homo sapiens]",57,17,137,17,312,35.1,6.13,367.38,"other metabolic processes","non-structural extracellular;nucleus;other cell component","kinase activity;other molecular function","HEL-S-1a; PDXK","ENSG00000160209","Vitamin B6 metabolism; Metabolic pathways; Biosynthesis of cofactors","Neutrophil degranulation; Vitamins B6 activation to pyridoxal phosphate","",11559.5,11830.9,11624.1,10624.9,10519.4,8501,1.1811147129561854,0.24014908986297936,0.061855770014018624,1.2086197823991534,0.26975168438691055,0.5690358348094382,1676]
["O00767","acyl-CoA desaturase [OS=Homo sapiens]",13,5,23,5,359,41.5,9,75.05,"other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","SCD","ENSG00000099194","Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; AMPK signaling pathway; Alcoholic liver disease","Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis","Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Adipogenesis; Liver X receptor pathway; Nuclear receptors meta-pathway; Fatty acid biosynthesis; Angiopoietin-like protein 8 regulatory pathway; PPAR signaling pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways",2904,3043.2,3034.8,4986.8,6148,2671.5,0.6505725646987246,-0.620218111130611,0.19100793111130415,0.7189485994205287,0.439294200280844,0.35724453040791637,3178]
["O14492","SH2B adapter protein 2 [OS=Homo sapiens]",13,4,8,4,632,67.7,6.27,21.53,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;other molecular function","SH2B2","ENSG00000160999","Neurotrophin signaling pathway; Insulin signaling pathway","Regulation of KIT signaling; Factors involved in megakaryocyte development and platelet production","Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; Insulin signaling",106.7,96.3,108.4,120.6,118,143.7,0.8145435521841486,-0.2959362557556116,0.05845277336471381,1.2331948783701039,0.2622660040041088,0.5812580007946402,1629]
["O14494","Phospholipid phosphatase 1 [OS=Homo sapiens]",4,1,2,1,284,32.1,7.97,6.94,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","PLPP1","ENSG00000067113","Glycerolipid metabolism; Glycerophospholipid metabolism; Ether lipid metabolism; Sphingolipid metabolism; Metabolic pathways; Phospholipase D signaling pathway; Fc gamma R-mediated phagocytosis; Fat digestion and absorption; Choline metabolism in cancer","Sphingolipid de novo biosynthesis","Androgen receptor signaling pathway; Androgen receptor signaling pathway; Sphingolipid pathway; Triacylglyceride synthesis; Androgen receptor signaling pathway",337.7,312.1,352.5,358.4,327.4,393,0.9290878754171301,-0.1061130381794771,0.317015776964023,0.49891912365633323,0.5371043842906917,0.2699413025388865,4314]
["O14497","AT-rich interactive domain-containing protein 1A [OS=Homo sapiens]",21,40,81,38,2285,241.9,6.7,259.41,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ARID1A","ENSG00000117713","Thermogenesis; Hepatocellular carcinoma","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines","Pathways affected in adenoid cystic carcinoma; Tumor suppressor activity of SMARCB1; Thermogenesis",7511,7377.4,7537.3,8249.5,8664.5,9550.9,0.8473752026268756,-0.23892718422979387,0.025371027586002307,1.5956619424789877,0.181267683896472,0.741679614307175,1023]
["O14523","Phospholipid transfer protein C2CD2L [OS=Homo sapiens]",21,11,23,11,706,76.1,7.69,62.31,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","transporter activity;other molecular function","C2CD2L","ENSG00000172375","","","",1092,1207.3,1242.2,958.5,1110.6,1685.9,0.9431424766977363,-0.08445236545183542,0.7686936514284828,0.11424670571486606,0.8420836178493376,0.0746447814605754,6672]
["O14524-1","Nuclear envelope integral membrane protein 1 [OS=Homo sapiens]",8,4,9,4,444,50.6,6.93,22.32,"cell organization and biogenesis","other membranes;nucleus","","NEMP1","ENSG00000166881","","","",1248.5,1336.3,1310.9,1438.4,1364.9,1897.1,0.8288018041017787,-0.27090095146007626,0.18670346457920317,0.7288476229525317,0.4350065739908818,0.3615041797663038,3137]
["O14526-1","F-BAR domain only protein 1 [OS=Homo sapiens]",4,4,4,4,889,96.8,6.96,10.43,"cell organization and biogenesis;transport","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","FCHO1","ENSG00000130475","","Cargo recognition for clathrin-mediated endocytosis","",148.5,139.5,150.1,185.4,176.8,409.7,0.5675605648400052,-0.8171537431320056,0.2185718781067836,0.6604057159851133,0.46426674137822765,0.3332324267220705,3441]
["O14530","Thioredoxin domain-containing protein 9 [OS=Homo sapiens]",33,6,14,6,226,26.5,5.88,40.52,"","cytosol;cytoskeleton;nucleus;other cell component","","TXNDC9","ENSG00000115514","","","",1247.2,1227.8,1185.3,1868.3,1816.3,1616,0.6905444666641513,-0.5341937770436788,0.002293124666127596,2.639572334132009,0.054952289130251145,1.2600142115948216,305]
["O14531","dihydropyrimidinase-related protein 4 [OS=Homo sapiens]",11,2,16,2,572,61.8,7.09,35.54,"cell organization and biogenesis;developmental processes;other biological processes","cytosol","cytoskeletal activity;other molecular function","DPYSL4","ENSG00000151640","","CRMPs in Sema3A signaling","",761.1,834.1,851.1,791.6,747,1400.1,0.8324429169360603,-0.26457674916209256,0.4829104164987238,0.31613342665778965,0.6337928235211299,0.19805268266357576,5569]
["O14545","TRAF-type zinc finger domain-containing protein 1 [OS=Homo sapiens]",2,1,1,1,582,64.8,5.29,1.98,"other biological processes","","other molecular function","TRAFD1","ENSG00000135148","","","Regulation of toll-like receptor signaling pathway",91.9,86.8,104.2,121.2,127,28.6,1.0220375722543353,0.031448233759528224,0.9528150310189294,0.020991400310870656,0.9688543491537778,0.013741506863833918,7188]
["O14548","Cytochrome c oxidase subunit 7A-related protein, mitochondrial [OS=Homo sapiens]",11,1,1,1,114,12.6,9.42,3.72,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion;nucleus","transporter activity","COX7A2L","ENSG00000115944","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease",100.7,101.5,86.3,131,132,109,0.7755376344086022,-0.3667313024625487,0.03629613513275398,1.440139616833837,0.20971419105557224,0.6783721804617007,1265]
["O14561","Acyl carrier protein, mitochondrial [OS=Homo sapiens]",13,2,3,2,156,17.4,4.93,8.5,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;nucleus","other molecular function","NDUFAB1","ENSG00000004779","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Glyoxylate metabolism and glycine degradation; Mitochondrial Fatty Acid Beta-Oxidation; Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",231.6,244.5,237.6,237.4,356.7,597,0.5991940223322979,-0.7389048636049954,0.20704448561262134,0.6839363319324392,0.45403184678747355,0.3429136837089963,3333]
["O14562","Ubiquitin domain-containing protein UBFD1 [OS=Homo sapiens]",19,4,13,4,309,33.4,5.77,35.8,"","","","UBFD1","ENSG00000103353","","","",1584.2,1669.6,1554.7,1890.3,1816.8,1556.1,0.913607691138471,-0.13035329891446845,0.22989203498311556,0.6384760753718906,0.4729189090041068,0.3252133209772456,3553]
["O14576-1","cytoplasmic dynein 1 intermediate chain 1 [OS=Homo sapiens]",6,3,4,3,645,72.9,5.12,8.9,"transport;other biological processes","cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","DNCI1; DYNC1I1","ENSG00000158560; ENSGGOG00000000228; ENSPTRG00000019422","Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection","Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Intraflagellar transport proteins binding to dynein",220,203.5,225.6,227.8,215.2,327.7,0.8422213572077332,-0.2477286347840444,0.3255217201746423,0.487420028179405,0.5393874977910815,0.2680991240738394,4411]
["O14578-4","Isoform 4 of Citron Rho-interacting kinase [OS=Homo sapiens]",5,9,11,9,2069,236.5,6.67,18.9,"","","","CIT","","","","",684.2,693.4,653.9,653.9,668.8,616.2,1.0477590386301512,0.06730696711935526,0.1918983046287185,0.7169288621256269,0.44009560983097074,0.35645296371538654,3187]
["O14579-1","coatomer subunit epsilon [OS=Homo sapiens]",36,11,48,11,308,34.5,5.12,138.59,"transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","COPE","ENSG00000105669; ENSPTRG00000010723","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport","",5970.2,5999.1,5986.4,5904.8,5629.1,4351.1,1.130355681460497,0.17677680727548895,0.22277796369370814,0.6521277700491783,0.46682458045794517,0.33084628442573494,3488]
["O14593","DNA-binding protein RFXANK [OS=Homo sapiens]",4,1,1,1,260,28.1,4.55,0,"signal transduction;other biological processes","non-structural extracellular;cytosol;nucleus","nucleic acid binding activity;other molecular function","RFXANK","ENSG00000064490","Antigen processing and presentation; Tuberculosis; Primary immunodeficiency","","",72.4,60.9,76.6,97.1,92.3,180.7,0.5671440151310457,-0.8182129690080661,0.14020943634412505,0.8532227565956562,0.3899508258140069,0.4089901555994263,2628]
["O14617-5","Isoform 5 of AP-3 complex subunit delta-1 [OS=Homo sapiens]",36,40,125,40,1215,136.6,7.64,411.02,"","","","AP3D1","","","","",12324,12446.9,12579.8,12059.2,12303.9,11535.3,1.0404558420430994,0.05721573699319061,0.1121681059790801,0.9501306133683288,0.35444733532256656,0.4504482842549753,2313]
["O14618","copper chaperone for superoxide dismutase [OS=Homo sapiens]",16,5,19,5,274,29,5.58,36.89,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","CCS","ENSG00000173992","Amyotrophic lateral sclerosis; Pathways of neurodegeneration","Detoxification of Reactive Oxygen Species","Amyotrophic lateral sclerosis (ALS); Copper homeostasis",1869.1,1783.6,1807.3,1892.3,1917,3252.6,0.7731630297795211,-0.371155440821042,0.3011365350023476,0.5212365510719025,0.5268087444548011,0.27834702483221924,4178]
["O14628-1","Zinc finger protein 195 [OS=Homo sapiens]",7,3,4,1,629,72.3,8.09,5.49,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF195","ENSG00000005801","Herpes simplex virus 1 infection","Generic Transcription Pathway","",28,30,21.3,25.6,36.6,9.4,1.1075418994413406,0.14736127843972183,0.7732677497794707,0.11167010230725284,0.8449415433006655,0.07317333637591317,6689]
["O14639-1","Actin-binding LIM protein 1 [OS=Homo sapiens]",7,5,6,5,778,87.6,8.59,12.99,"cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ABLIM1","ENSG00000099204","Axon guidance","DCC mediated attractive signaling","Male infertility",739.5,692.7,755.8,767.6,728.4,1006,0.8745003996802558,-0.19346905137326317,0.30375292112119795,0.5174795368645213,0.5282251012312242,0.2771809649859855,4203]
["O14641","Segment polarity protein dishevelled homolog DVL-2 [OS=Homo sapiens]",6,4,6,2,736,78.9,6.02,11.66,"cell-cell signaling;cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","DVL2","ENSG00000004975","mTOR signaling pathway; Wnt signaling pathway; Notch signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer","RHO GTPases Activate Formins; Asymmetric localization of PCP proteins; Degradation of DVL; Cargo recognition for clathrin-mediated endocytosis; WNT mediated activation of DVL; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Negative regulation of TCF-dependent signaling by DVL-interacting proteins; WNT5:FZD7-mediated leishmania damping; Signaling by Hippo; WNT5A-dependent internalization of FZD4","Alzheimer's disease and miRNA effects; Neural crest differentiation; Notch signaling; Wnt signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Type 2 papillary renal cell carcinoma; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Malignant pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)",173,158.2,168.8,252.2,264.8,468.8,0.5072022722661798,-0.9793668861217812,0.08272004705379377,1.0823892272095479,0.31197152936851325,0.5058850380403215,1938]
["O14646","Chromodomain-helicase-DNA-binding protein 1 [OS=Homo sapiens]",13,18,26,15,1710,196.6,7.14,58.47,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CHD1","ENSG00000153922","","Estrogen-dependent gene expression","",2141,2105,2120.3,2481.4,2504.8,2489.5,0.8515991813475661,-0.23175353197641135,7.7369775189337519E-6,5.111428665054925,0.006283285409542977,2.2018132126102765,9]
["O14647","Chromodomain-helicase-DNA-binding protein 2 [OS=Homo sapiens]",11,17,26,14,1828,211.2,8.1,66.08,"cell organization and biogenesis;stress response;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","CHD2","ENSG00000173575","","","Prion disease pathway; Male infertility",1401.1,1358.3,1357.8,1564.8,1646.3,1463,0.8808540681628547,-0.1830250684505966,0.02779941694526108,1.5559643127190168,0.1891861624328801,0.7231106321985806,1074]
["O14653-1","Golgi SNAP receptor complex member 2 [OS=Homo sapiens]",21,4,7,4,212,24.8,8.06,14.57,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","other molecular function","GOSR2","ENSG00000108433","SNARE interactions in vesicular transport","COPI-mediated anterograde transport; Intra-Golgi traffic; COPII-mediated vesicle transport; XBP1(S) activates chaperone genes; Cargo concentration in the ER","",639.4,617.6,626.4,641.8,730.6,596,0.9568177199756148,-0.06368398682686788,0.5179839607020386,0.2856836879119954,0.6598021555892646,0.18058626993800195,5738]
["O14656","Torsin-1A [OS=Homo sapiens]",20,6,14,6,332,37.8,6.99,37.88,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","TOR1A","ENSG00000136827","","Cargo recognition for clathrin-mediated endocytosis","",1342.1,1329.9,1340.1,1348,1279,1088.1,1.079944012274232,0.11095652043684594,0.27224271153178686,0.5650437383266311,0.5072194694330436,0.2948040845721941,3923]
["O14662-2","Isoform A of Syntaxin-16 [OS=Homo sapiens]",24,7,16,7,304,34.8,6.2,46.86,"","","","STX16","","","","",1042.1,1012.3,1057.7,834.2,976.3,1727.1,0.8797207146087742,-0.1848825115923556,0.6359845660508676,0.19655342359729933,0.7431512699066014,0.1289227757427651,6255]
["O14672","Disintegrin and metalloproteinase domain-containing protein 10 [OS=Homo sapiens]",38,25,56,25,748,84.1,7.77,170.99,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ADAM10","ENSG00000137845","Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection","Amyloid fiber formation; Collagen degradation; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; NOTCH3 Activation and Transmission of Signal to the Nucleus; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant; Signaling by EGFR; EPH-ephrin mediated repulsion of cells; NOTCH4 Activation and Transmission of Signal to the Nucleus","Alzheimer's disease and miRNA effects; Copper homeostasis; Canonical and non-canonical Notch signaling; VEGFA-VEGFR2 signaling pathway; 3q29 copy number variation syndrome; Interactions of natural killer cells in pancreatic cancer; Alzheimer's disease; Hypertrophy model",3583.9,3740.3,3885.4,4325.1,4485.8,5928.8,0.7605039451277841,-0.3949723629119138,0.08527446044060426,1.069181019835072,0.3155802690432286,0.500890157913578,1975]
["O14681","Etoposide-induced protein 2.4 homolog [OS=Homo sapiens]",2,1,3,1,340,38.9,9.72,5.03,"other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus","other molecular function","EI24","ENSG00000149547","p53 signaling pathway","","miRNA regulation of p53 pathway in prostate cancer; Genotoxicity pathway",379,441.2,404.8,380.7,391.1,705.4,0.8292715949092879,-0.2700834184283181,0.48003670421703204,0.31872555464630664,0.6326340193152339,0.19884745800417655,5546]
["O14683","Tumor protein p53-inducible protein 11 [OS=Homo sapiens]",8,1,2,1,189,21,9.55,8.88,"other biological processes","other membranes","","TP53I11","ENSG00000175274","","","",132.8,142,128,133.4,139.1,273.4,0.737864077669903,-0.43857301373963264,0.3576759760937254,0.4465102289880476,0.5569351745353727,0.25419535236664836,4694]
["O14686-1","Histone-lysine N-methyltransferase 2D [OS=Homo sapiens]",4,13,15,12,5537,593,5.58,42.08,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","KMT2D","ENSG00000167548","Lysine degradation; Metabolic pathways; Cushing syndrome","Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","Histone modifications; 16p11.2 proximal deletion syndrome",613.4,589.2,575.6,707.1,728.6,1326.8,0.6436923076923076,-0.6355568665562381,0.18198813291638247,0.7399569305696644,0.43046966455852415,0.36605744811052604,3090]
["O14717-1","tRNA (cytosine(38)-C(5))-methyltransferase [OS=Homo sapiens]",2,1,2,1,391,44.6,6.09,5.15,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DNMT2; TRDMT1","ENSG00000107614","","tRNA modification in the nucleus and cytosol","",380.7,377.1,405,326.9,433.1,151.6,1.2755594559017112,0.35113014687094,0.36774101716606944,0.43445792701064273,0.561014212996619,0.2510261359848151,4791]
["O14730","serine/threonine-protein kinase RIO3 [OS=Homo sapiens]",12,6,7,6,519,59.1,5.76,17.24,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;other cell component","kinase activity;other molecular function","RIOK3","ENSG00000101782","","Major pathway of rRNA processing in the nucleolus and cytosol","",721.5,755,710.8,776.7,803.3,958,0.8618203309692671,-0.214540961810892,0.11439862923867504,0.9415791793685719,0.35686708540566614,0.4474935060815618,2343]
["O14732-1","inositol monophosphatase 2 [OS=Homo sapiens]",7,2,2,2,288,31.3,6.61,5.48,"other metabolic processes;signal transduction","cytosol;other cell component","other molecular function","IMPA2","ENSG00000141401","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of IP2, IP, and Ins in the cytosol","",159.5,157.2,151.8,166.1,172.4,249.5,0.7967687074829931,-0.3277671071771777,0.2128953898305662,0.6718337429431885,0.4596905182486288,0.3375344540803787,3385]
["O14733","dual specificity mitogen-activated protein kinase kinase 7 [OS=Homo sapiens]",18,6,10,6,419,47.5,9.16,26.35,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","MAP2K7","ENSG00000076984","MAPK signaling pathway; ErbB signaling pathway; Protein processing in endoplasmic reticulum; Osteoclast differentiation; Tight junction; Toll-like receptor signaling pathway; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; TNF signaling pathway; Neurotrophin signaling pathway; GnRH signaling pathway; Relaxin signaling pathway; Alcoholic liver disease; Alzheimer disease; Huntington disease; Pathways of neurodegeneration; Salmonella infection; Yersinia infection; Hepatitis B; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Chemical carcinogenesis; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; Uptake and function of anthrax toxins","Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; MAPK signaling pathway; ERK pathway in Huntington's disease; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; MAPK cascade; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; IL-18 signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Malignant pleural mesothelioma; Alzheimer's disease; ErbB signaling pathway; Toll-like receptor signaling pathway",1199.9,1078.2,1132.6,1208.7,1302.9,933.7,0.9899573331785331,-0.014561748016555513,0.9257213379616565,0.033519725627743226,0.9506951326628843,0.021958729570695654,7117]
["O14734","Acyl-coenzyme A thioesterase 8 [OS=Homo sapiens]",20,5,8,5,319,35.9,7.56,23.55,"cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle","other molecular function","ACOT8","ENSG00000101473","Primary bile acid biosynthesis; Metabolic pathways; Peroxisome","Peroxisomal protein import; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of pristanoyl-CoA; Beta-oxidation of very long chain fatty acids","",623.4,666.9,624.1,571,491.8,526,1.2049345417925477,0.26895477401012485,0.016008616986490778,1.7956461859495125,0.14535028764504482,0.8375841044334082,805]
["O14735","CDP-diacylglycerol--inositol 3-phosphatidyltransferase [OS=Homo sapiens]",25,5,18,5,213,23.5,8.03,34.86,"other metabolic processes","plasma membrane;other membranes;ER/Golgi","other molecular function","CDIPT","ENSG00000103502","Inositol phosphate metabolism; Glycerophospholipid metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of PI","Glycerolipids and glycerophospholipids; 16p11.2 proximal deletion syndrome",1567.4,1595,1612,1314.8,1364.5,1431.9,1.1613154310177074,0.21575988345008223,0.003689444726619622,2.43303899164886,0.07040770628423712,1.1523798037335098,383]
["O14744","Protein arginine N-methyltransferase 5 [OS=Homo sapiens]",37,21,49,21,637,72.6,6.29,162.74,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","PRMT5","ENSG00000100462","","snRNP Assembly; RMTs methylate histone arginines; Regulation of TP53 Activity through Methylation","Transcription co-factors SKI and SKIL protein partners; Nitric oxide metabolism in cystic fibrosis",6654.3,6586.8,6602.1,6239.4,6233.2,6015.1,1.0733190175089387,0.10207894522128629,0.004119260908882783,2.385180699497941,0.0745239554035254,1.1277041027245727,404]
["O14745","Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [OS=Homo sapiens]",69,21,108,21,358,38.8,5.77,328.28,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;transporter activity;cytoskeletal activity;other molecular function","SLC9A3R1","ENSG00000109062","Tight junction; Parathyroid hormone synthesis, secretion and action; Pathogenic Escherichia coli infection; Human papillomavirus infection","","",12667.2,12858.4,14118.4,14842,14667.6,15476.2,0.881255862961201,-0.18236714426228504,0.026241578464629208,1.5810100451401075,0.18531371690625592,0.732092433049071,1035]
["O14757","Serine/threonine-protein kinase Chk1 [OS=Homo sapiens]",4,2,2,2,476,54.4,8.25,5.21,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","CHEK1","ENSG00000149554","Cell cycle; p53 signaling pathway; Cellular senescence; Human T-cell leukemia virus 1 infection; Human immunodeficiency virus 1 infection; Viral carcinogenesis","Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Transcriptional Regulation by E2F6; Signaling by SCF-KIT; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex","miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; ATR signaling; ATM signaling in development and disease ; DNA repair pathways, full network; DNA damage response",175.9,174.6,179.9,468.5,406.6,199.1,0.49376280022342206,-1.0181099460429464,0.0901500157384449,1.0450341931221763,0.3242649926340028,0.48909993485008496,2032]
["O14772","fucose-1-phosphate guanylyltransferase [OS=Homo sapiens]",3,1,1,1,594,66.6,6.48,3.55,"","","other molecular function","FPGT","ENSG00000254685","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars","","",42.9,34.2,37.8,39.5,25.4,45,1.0454959053685167,0.06418741169688193,0.8061936840081717,0.09356060857833298,0.8697372157071184,0.060611946240803356,6775]
["O14773","Tripeptidyl-peptidase 1 [OS=Homo sapiens]",32,10,45,10,563,61.2,6.48,142.15,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","TPP1","ENSG00000166340","Lysosome","XBP1(S) activates chaperone genes","VEGFA-VEGFR2 signaling pathway",5766.1,5802.3,5786.2,5407.2,5617.3,6027.4,{"$f":"AVERAGE(S194:U194)/AVERAGE(V194:X194)","v":1.0177516874952353},{"$f":"LOG(Y194,2)","v":0.025385613557499905},{"$f":"TTEST(S194:U194,V194:X194,2,2)","v":0.609627017418214},{"$f":"-LOG10(AA194)","v":0.21493579420185632},{"$f":"AA194*7309/AE194","v":0.7229861869722094},{"$f":"-LOG10(AC194)","v":0.1408700000485587},6163]
["O14776-1","Transcription elongation regulator 1 [OS=Homo sapiens]",25,33,92,33,1098,123.8,8.65,229.28,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","TCERG1","ENSG00000113649; ENSGGOG00000003329; ENSPTRG00000017375","Spliceosome","","",13056,12678.4,12842.4,13546.6,13575.3,13963.2,0.9389486699557748,-0.09088180348795126,0.008476933144080058,2.071761242025139,0.10700847038010561,0.970581843868602,579]
["O14777","Kinetochore protein NDC80 homolog [OS=Homo sapiens]",29,18,37,18,642,73.9,5.6,94.67,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","NDC80","ENSG00000080986","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",4422.5,4512.1,4451.2,5123.2,5579.2,3890,0.9173131218990708,-0.12451381766211687,0.47056472903761715,0.32738062828281134,0.6267051028673367,0.2029367690975336,5488]
["O14782","Kinesin-like protein KIF3C [OS=Homo sapiens]",3,3,5,1,793,89.4,8.22,10.83,"transport;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF3C","ENSG00000084731","","Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins","",368.3,332.9,399.7,329.1,273.9,497.8,1.0000908430232558,1.3105282662312698E-4,0.9996431388553163,1.5501048619691885E-4,0.9999167513197629,3.6155947441047073E-5,7307]
["O14787-2","Isoform 2 of Transportin-2 [OS=Homo sapiens]",30,19,68,11,887,100.3,4.98,205.82,"","","","TNPO2","","","","",1706.9,1685.6,1806.2,1506.4,1518.2,1350.3,1.1883014468902144,0.24890086372032733,0.013880028728248029,1.8576096349973972,0.1345479177384149,0.8711230189831983,754]
["O14795","Protein unc-13 homolog B [OS=Homo sapiens]",14,16,28,16,1591,180.6,5.99,85.29,"cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","UNC13B","ENSG00000198722","Synaptic vesicle cycle","Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle","Synaptic vesicle pathway; 16p11.2 proximal deletion syndrome; Monoamine transport",1786.4,1750.2,1828.8,1847.4,1900.7,2540.4,0.8532082372584879,-0.22903020071074756,0.24116157575810918,0.6176918871021906,0.4829177964975397,0.3161267896746924,3650]
["O14802","DNA-directed RNA polymerase III subunit RPC1 [OS=Homo sapiens]",22,26,44,25,1390,155.5,8.48,120,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR3A","ENSG00000148606","RNA polymerase; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","Pyrimidine metabolism; Cytosolic DNA-sensing pathway",4655.1,4682.2,4637.1,4610.6,4636.6,4556,1.0124029210617829,0.0177835751405203,0.10322498307744045,0.9862151796508852,0.340465433805511,0.46792697382330434,2216]
["O14818-1","Proteasome subunit alpha type-7 [OS=Homo sapiens]",63,16,110,16,248,27.9,8.46,348.28,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","HEL-S-276; PSMA7","ENSG00000101182","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease",12794.2,12597.8,12247,12164.8,11610.6,8384.4,1.1703741938693648,0.22696986427876412,0.19947161927519602,0.7001188867891268,0.44667220137328667,0.3500110749869774,3264]
["O14828","Secretory carrier-associated membrane protein 3 [OS=Homo sapiens]",56,13,79,13,347,38.3,7.64,296.69,"transport","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SCAMP3","ENSG00000116521; ENSG00000263290","","","",5443.3,5402.7,5382.8,5118.4,5874.1,5729.6,0.970500116612148,-0.043199708598853546,0.5180822819703503,0.28560126000796565,0.6598124061546071,0.180579522870951,5739]
["O14832","Phytanoyl-CoA dioxygenase, peroxisomal [OS=Homo sapiens]",5,2,2,2,338,38.5,8.47,4.08,"other metabolic processes","cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","PHYH","ENSG00000107537","Peroxisome","TYSND1 cleaves peroxisomal proteins; Alpha-oxidation of phytanate","",160.6,160.9,151.9,169.8,191.3,148.7,0.9285994507650057,-0.10687166728758732,0.39169134805976286,0.40705602133291385,0.5742973045072832,0.2408632220966154,4985]
["O14836","Tumor necrosis factor receptor superfamily member 13B [OS=Homo sapiens]",7,1,1,1,293,31.8,7.94,4.71,"developmental processes;signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","TNFRSF13B","ENSG00000240505","Cytokine-cytokine receptor interaction; Intestinal immune network for IgA production; Primary immunodeficiency","TNFs bind their physiological receptors","",34.5,30.3,37.5,60.8,62.7,176.9,0.3405459387483356,-1.5540786677689429,0.1609922735623105,0.7931949663890994,0.4127297535836294,0.3843342218145864,2851]
["O14867","Transcription regulator protein BACH1 [OS=Homo sapiens]",9,6,6,6,736,81.9,5.05,18.29,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","BACH1","ENSG00000156273","","Heme signaling; Regulation of HMOX1 expression and activity; Regulation of BACH1 activity","Integrated cancer pathway; Ferroptosis",274.7,253,252.1,314.9,280.4,374.4,0.8041662369805096,-0.3144343292083182,0.08995930709377939,1.0459538983509786,0.32421724632565757,0.4891638871283041,2028]
["O14874","[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial [OS=Homo sapiens]",24,7,11,7,412,46.3,8.82,34.8,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","kinase activity;other molecular function","BCKDK","ENSG00000103507","","Branched-chain amino acid catabolism","Thiamine metabolic pathways",1241.1,1219.5,1220.9,1556.8,1344.9,1617.2,0.8146894155657352,-0.29567793005021537,0.02807292345104604,1.5517123585609132,0.18981035846780345,0.7216800906302506,1081]
["O14880","Microsomal glutathione S-transferase 3 [OS=Homo sapiens]",38,4,23,4,152,16.5,9.38,79.97,"other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","MGST3","ENSG00000143198","Glutathione metabolism; Metabolism of xenobiotics by cytochrome P450; Drug metabolism; Drug metabolism; Metabolic pathways; Platinum drug resistance; Pathways in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Chemical carcinogenesis; Hepatocellular carcinoma; Fluid shear stress and atherosclerosis","Aflatoxin activation and detoxification; Glutathione conjugation","Nuclear receptors meta-pathway; NRF2 pathway; Metapathway biotransformation Phase I and II",3470.2,3444,3491.6,3059.4,3020.6,1386.6,1.3936463718426055,0.4788645337238824,0.15025245835577825,0.8231784135574037,0.40300741949445257,0.394686958286092,2725]
["O14893","Gem-associated protein 2 [OS=Homo sapiens]",14,3,6,3,280,31.6,5.58,17.9,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","","GEMIN2","ENSG00000092208","","snRNP Assembly","",456.8,380.7,470,461.3,546.8,1025.1,0.6430749557348023,-0.6369411894267782,0.24488895601647007,0.6110308002132041,0.48546063995779215,0.3138459759353477,3687]
["O14920-1","Inhibitor of nuclear factor kappa-B kinase subunit beta [OS=Homo sapiens]",26,12,24,12,756,86.5,5.78,76.67,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","IKBKB","ENSG00000104365","Antifolate resistance; MAPK signaling pathway; Ras signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; FoxO signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; TNF signaling pathway; Neurotrophin signaling pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; Alcoholic liver disease; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Chagas disease; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Pancreatic cancer; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; CLEC7A (Dectin-1) signaling; IKK complex recruitment mediated by RIP1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation","Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNAs involvement in the immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Nonalcoholic fatty liver disease; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; Insulin signaling; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; T-cell receptor (TCR) signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway",1733,1788.8,1751.9,1795.6,1692.1,1936.7,0.9722181255069687,-0.04064806368695648,0.5278961606049212,0.2774514966165073,0.6675420480729012,0.1755213731530634,5780]
["O14929","histone acetyltransferase type B catalytic subunit [OS=Homo sapiens]",44,14,93,14,419,49.5,5.69,261.91,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","mitochondrion;nucleus;other cell component","other molecular function","HAT1","ENSG00000128708","Neutrophil extracellular trap formation; Alcoholism","HATs acetylate histones","Ethanol effects on histone modifications",11208.7,11035.2,10961.2,10441.6,9834.6,9981.5,1.0974099154925856,0.1341025162469728,0.007558827964025076,2.1215455389189923,0.10044995198010777,0.9980502665292632,550]
["O14933","Ubiquitin/ISG15-conjugating enzyme E2 L6 [OS=Homo sapiens]",15,2,3,2,153,17.8,7.88,9.18,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","UBE2L6","ENSG00000156587","Ubiquitin mediated proteolysis; Parkinson disease; Pathways of neurodegeneration","Antigen processing: Ubiquitination & Proteasome degradation; Amyloid fiber formation; ISG15 antiviral mechanism; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling","Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway; 7q11.23 copy number variation syndrome",451.1,450,404.7,619.4,783.5,462.4,0.7000482496113224,-0.5144737341496606,0.11811952830005142,0.9276782960203169,0.36137950286524734,0.44203648388622185,2389]
["O14936","peripheral plasma membrane protein CASK [OS=Homo sapiens]",6,5,8,5,926,105.1,6.43,25.47,"cell adhesion;protein metabolism;other metabolic processes;transport;other biological processes","extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","CASK","ENSG00000147044","","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Assembly and cell surface presentation of NMDA receptors; Nephrin family interactions; Neurexins and neuroligins; Dopamine Neurotransmitter Release Cycle; Syndecan interactions","Parkin-ubiquitin proteasomal system pathway; Splicing factor NOVA regulated synaptic proteins",777.5,736.2,770.6,609.2,608.6,881.8,1.087969136978472,0.12163763144151983,0.5394196191051396,0.2680732619725749,0.6752214413494546,0.17055377533988922,5839]
["O14949","Cytochrome b-c1 complex subunit 8 [OS=Homo sapiens]",30,4,17,4,82,9.9,10.08,40.67,"other metabolic processes;transport;developmental processes","other membranes;mitochondrion","","UQCRQ","ENSG00000164405","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly",3890.8,4077.3,3657.4,3560.8,4564.9,2446,1.099681224400995,0.13708537590745776,0.6034786829078659,0.21933806617805476,0.7189609932149295,0.1432946713571048,6135]
["O14950","Myosin regulatory light chain 12B [OS=Homo sapiens]",66,11,109,11,172,19.8,4.84,318.93,"other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYL12B","ENSG00000118680","Axon guidance; Focal adhesion; Tight junction; Platelet activation; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Shigellosis; Salmonella infection","RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs","Thyroid stimulating hormone (TSH) signaling pathway; Focal adhesion",7260.2,7785.7,8481.3,8901,9224.1,9556.3,0.849928110572442,-0.23458727588025438,0.025990394007738244,1.585187136655605,0.18407343973116166,0.7350088720628246,1032]
["O14964","Hepatocyte growth factor-regulated tyrosine kinase substrate [OS=Homo sapiens]",26,19,36,19,777,86.1,6.16,92.11,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","HGS","ENSG00000185359","Endocytosis; Phagosome","Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; Endosomal Sorting Complex Required For Transport (ESCRT); Ub-specific processing proteases; RHOU GTPase cycle; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Inhibition of membrane repair; Prevention of phagosomal-lysosomal fusion; RHOBTB3 ATPase cycle","TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway",4417.4,4426.1,4382.5,4465.3,4814.4,6327.4,0.8474348213313172,-0.238825684229131,0.23730745715881743,0.6246886142814407,0.4791381780038112,0.3195392229306335,3620]
["O14965","Aurora kinase A [OS=Homo sapiens]",15,5,6,5,403,45.8,9.39,16.59,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","AURKA","ENSG00000087586","Oocyte meiosis; Progesterone-mediated oocyte maturation","APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; SUMOylation of DNA replication proteins; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Interaction between PHLDA1 and AURKA","Integrated breast cancer pathway; Gastric cancer network 1; EGF/EGFR signaling pathway",502.3,523.4,518.8,536.9,485.6,846.2,0.826510408305239,-0.27489510729257643,0.39233385207525157,0.4063442176537885,0.5744327173113007,0.24076083244418311,4992]
["O14967","calmegin [OS=Homo sapiens]",22,10,25,9,610,70,4.69,63.37,"cell organization and biogenesis;stress response;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","CLGN","ENSG00000153132","","","",1578.6,1588,1615.1,1482,1599.7,1672.4,1.0058055152394774,0.00835136943292219,0.8786350531749405,0.05619147453214071,0.9180762835819356,0.03712123147601422,6995]
["O14972","Down syndrome critical region protein 3 [OS=Homo sapiens]",16,3,8,3,297,33,7.68,19.29,"transport","other cytoplasmic organelle","","VPS26C","ENSG00000157538","","","",524,553.4,535.2,534.5,480.3,399,1.1406139482246431,0.1898105802115284,0.1754233386011028,0.7559126278947151,0.42611139309918916,0.37047685375082273,3009]
["O14974","Protein phosphatase 1 regulatory subunit 12A [OS=Homo sapiens]",51,50,148,3,1030,115.2,5.4,403.41,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP1R12A","ENSG00000058272","cGMP-PKG signaling pathway; cAMP signaling pathway; Vascular smooth muscle contraction; Focal adhesion; Platelet activation; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Proteoglycans in cancer","Regulation of PLK1 Activity at G2/M Transition; RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs","Focal adhesion; Hippo-Merlin signaling dysregulation; Regulation of actin cytoskeleton",20934.9,20460.8,20777.4,22099,22183.2,14814.9,1.0520499313841118,0.07320317806250598,0.6966302069354648,0.15699769780634976,0.788184238775745,0.10337225391746091,6460]
["O14974-4","Isoform 4 of Protein phosphatase 1 regulatory subunit 12A [OS=Homo sapiens]",53,48,152,1,971,109,5.41,415.41,"","","","PPP1R12A","","","","",579.7,548.2,558.6,615.7,604.8,512.4,0.9732240752495815,-0.03915608532457653,0.6732444995434748,0.1718271861194601,0.7723660409925063,0.11217682931752854,6371]
["O14975","very long-chain acyl-CoA synthetase [OS=Homo sapiens]",23,11,29,11,620,70.3,8.51,72.21,"other metabolic processes;transport","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","transporter activity;other molecular function","SLC27A2","ENSG00000140284","PPAR signaling pathway; Peroxisome; Insulin resistance","Peroxisomal protein import; Neutrophil degranulation; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Alpha-oxidation of phytanate; Synthesis of bile acids and bile salts via 24-hydroxycholesterol","PPAR signaling pathway",2406,2388.2,2426.3,2091.2,2281.9,3344.1,0.9356372777691391,-0.09597875202847266,0.6929540496414703,0.15929556286118796,0.7860936130419847,0.10452573232356122,6443]
["O14976","Cyclin-G-associated kinase [OS=Homo sapiens]",23,22,59,22,1311,143.1,5.73,183.19,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;ER/Golgi;other cell component","kinase activity;other molecular function","GAK","ENSG00000178950","","Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis","",5163.1,5217,5282.6,5640.1,5590.7,6262.5,0.8953542213304524,-0.1594695384818539,0.04944385148708452,1.3058877067210495,0.24434422617924323,0.6119979188339691,1479]
["O14979-1","Heterogeneous nuclear ribonucleoprotein D-like [OS=Homo sapiens]",30,15,127,13,420,46.4,9.57,302.04,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","HNRNPDL; HNRPDL","ENSG00000152795; ENSPPAG00000043177; ENSPTRG00000016217","","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","",12222.5,12146,12348.1,12641.1,14005.7,8899.1,1.0329348813787245,0.046749306213409364,0.8109704229900496,0.09099498471171458,0.8736010053993033,0.05868687482349747,6785]
["O14980","Exportin-1 [OS=Homo sapiens]",47,39,166,39,1071,123.3,6.06,503.63,"transport;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","XPO1","ENSG00000082898","Ribosome biogenesis in eukaryotes; Nucleocytoplasmic transport; Influenza A; Human T-cell leukemia virus 1 infection","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; MAPK6/MAPK4 signaling; Deactivation of the beta-catenin transactivating complex; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Heme signaling; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Downregulation of TGF-beta receptor signaling; HuR (ELAVL1) binds and stabilizes mRNA; Cyclin A/B1/B2 associated events during G2/M transition","eIF5A regulation in response to inhibition of the nuclear export system; 22q11.2 copy number variation syndrome",17147.2,17286.4,17449,16609.7,15939.8,14510.8,1.102470659983043,0.14074026189598893,0.061876818752584245,1.208472022602169,0.26952185236152454,0.5694060172108776,1678]
["O14981","TATA-binding protein-associated factor 172 [OS=Homo sapiens]",15,20,44,20,1849,206.8,6.52,146.79,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","BTAF1","ENSG00000095564","","","",3134.6,3204.7,3084,3293.8,3497.7,3862.9,0.8844514942183511,-0.17714507121360398,0.07336527006045827,1.1345094794649442,0.294630087292247,0.530722905566046,1820]
["O14986","Phosphatidylinositol 4-phosphate 5-kinase type-1 beta [OS=Homo sapiens]",5,2,3,1,540,61,6.86,6.4,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","kinase activity;other molecular function","PIP5K1B","ENSG00000107242","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Phospholipase D signaling pathway; Endocytosis; Focal adhesion; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Yersinia infection; Choline metabolism in cancer","Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; WNT mediated activation of DVL","B cell receptor signaling pathway; Wnt signaling pathway; Regulation of actin cytoskeleton",27.8,37.6,36.5,40,37.5,56.3,0.7615844544095666,-0.392924064475647,0.1855740997445662,0.7314826376157224,0.43375794532556267,0.36275255697468267,3127]
["O15014","zinc finger protein 609 [OS=Homo sapiens]",1,1,1,1,1411,151.1,8.03,2.25,"developmental processes;other biological processes","nucleus","other molecular function","ZNF609","ENSG00000180357","","","",120.9,101.7,113.6,191,173.3,185.5,0.6114950891233176,-0.7095871822767857,7.4501671887658362E-4,3.1278339811653013,0.03184401870332719,1.4969721296734821,171]
["O15015","Zinc finger protein 646 [OS=Homo sapiens]",1,1,1,1,1829,200.6,7.33,3.44,"","","","","","","","",84.7,104.5,94,117.5,116.3,257.6,0.5763125763125763,-0.7950765922791675,0.2158068063960522,0.6659348620922562,0.4624250800201541,0.3349586196156804,3411]
["O15020","Spectrin beta chain, non-erythrocytic 2 [OS=Homo sapiens]",13,30,70,16,2390,271.2,6.11,202.36,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SPTBN2","ENSG00000173898","Spinocerebellar ataxia; Pathways of neurodegeneration","MHC class II antigen presentation; COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins","",914.8,934.4,999.1,907,941.9,2017.4,0.7366991697488554,-0.44085247816186585,0.40556531827637277,0.39193919057114346,0.5806614909465247,0.23607697511009948,5105]
["O15027-5","Isoform 5 of Protein transport protein Sec16A [OS=Homo sapiens]",22,34,83,34,2201,235.6,5.67,232.92,"","","","","","","","",7848.1,7601.9,7816.4,7680.2,7940.7,10692,0.8842202873875552,-0.17752225928612025,0.352706661450833,0.45258633788278474,0.5547520956626077,0.25590104847768025,4647]
["O15031","Plexin-B2 [OS=Homo sapiens]",6,10,18,9,1838,205,6.24,46.43,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","PLXNB2","ENSG00000196576","Axon guidance","","",742,770,743.8,748.7,678.7,1592.7,0.7469289096387536,-0.4209571565478461,0.4348365186423445,0.36167398993334254,0.5996641725956408,0.22209189765015863,5300]
["O15037","protein KHNYN [OS=Homo sapiens]",7,4,4,4,678,74.5,7.02,12.78,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KHNYN","ENSG00000100441","","","",338.4,315,342.2,320.6,326.6,443.7,0.9126409386744887,-0.13188072414350502,0.48134472629851843,0.31754378203308664,0.6327605403805524,0.19876061173117113,5560]
["O15042-2","Isoform 2 of U2 snRNP-associated SURP motif-containing protein [OS=Homo sapiens]",31,24,78,1,1028,118.2,8.47,207.63,"","","","U2SURP","","","","",7244.5,7087.1,7126.9,7732.4,7754.8,5273.8,1.0335966475603295,0.04767329581404687,0.7919760653681864,0.10128794320292107,0.8579447253262302,0.06654069147424269,6747]
["O15047","Histone-lysine N-methyltransferase SETD1A [OS=Homo sapiens]",6,8,12,8,1707,185.9,5.14,36.58,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SETD1A","ENSG00000099381","Lysine degradation; Metabolic pathways","PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","Histone modifications",639.5,655.2,636,645.7,674.9,1386.3,0.7132513206989547,-0.487517581697166,0.34561751807681224,0.46140425285032305,0.5519157613334981,0.25812720339364964,4577]
["O15050","TPR and ankyrin repeat-containing protein 1 [OS=Homo sapiens]",1,1,1,1,2925,336,6.76,0,"","","","TRANK1","ENSG00000168016","","","",30.4,36,17.5,30.9,24.4,35.5,0.9240088105726874,-0.11402148685109155,0.7356682346398118,0.1333179959195493,0.8187907913784657,0.0868270503231705,6567]
["O15056","Synaptojanin-2 [OS=Homo sapiens]",3,4,4,4,1496,165.4,7.34,11.76,"cell organization and biogenesis;other metabolic processes;transport;developmental processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity;other molecular function","SYNJ2","ENSG00000078269","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane","",368.7,331.3,370.5,394.9,354,683.2,0.7475036659451156,-0.41984744022161025,0.31246680814608113,0.5051961088946078,0.5334781361223329,0.2728833748449442,4281]
["O15061-1","Synemin [OS=Homo sapiens]",4,5,5,5,1565,172.7,5.16,13.83,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SYNM","ENSG00000182253","","","",160.3,164.6,166.7,159.9,165.8,252.1,0.8508134302526824,-0.23308528819195412,0.390381097634415,0.40851121916059946,0.5736420270627139,0.2413590382105437,4974]
["O15062","zinc finger and BTB domain-containing protein 5 [OS=Homo sapiens]",2,1,1,1,677,74.2,6.19,3.91,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB5","ENSG00000168795","","","",42.7,54.6,46.1,54.3,63.8,123.1,0.5945273631840797,-0.7501848831981798,0.20937399398256568,0.6790772623480112,0.4558577664636796,0.34117064171205075,3357]
["O15066","Kinesin-like protein KIF3B [OS=Homo sapiens]",18,11,14,9,747,85.1,7.69,41.08,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF3B","ENSG00000101350","","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins","",1191.1,1176.2,1170.6,1330.2,1336.7,1117.4,0.934888883016674,-0.0971331923974517,0.31940121521250564,0.4956634358522586,0.5374087205313545,0.26969529054907615,4344]
["O15067","Phosphoribosylformylglycinamidine synthase [OS=Homo sapiens]",33,35,110,35,1338,144.6,5.76,331.34,"other metabolic processes;other biological processes","cytosol","other molecular function","PFAS","ENSG00000178921","Purine metabolism; Metabolic pathways","Purine ribonucleoside monophosphate biosynthesis","",13429.9,13238,13411.1,12803.2,13171.3,14186.5,0.9979582181718583,-2.9486798239144927E-3,0.9510142437426867,0.021812978401676234,0.9678311205117374,0.014200417307757542,7182]
["O15078-1","Centrosomal protein of 290 kDa [OS=Homo sapiens]",1,2,4,2,2479,290.2,5.95,10.65,"cell organization and biogenesis;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","CEP290","ENSG00000198707","","Neutrophil degranulation; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","Clear cell renal cell carcinoma pathways; Ciliary landscape; Joubert syndrome; Ciliopathies",1310,1290.8,1124.3,1358.8,1425.2,1782.5,0.8157451001861382,-0.293809678164326,0.12362447132885956,0.9078955526198397,0.3686541252315931,0.43338090198794466,2451]
["O15084","serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A [OS=Homo sapiens]",14,11,22,9,1053,112.9,6.25,80.85,"","cytosol;nucleus","","ANKRD28","ENSG00000206560","","Telomere Extension By Telomerase; COPII-mediated vesicle transport","",1457.5,1425.7,1487.3,1468.1,1427.2,1690.3,0.9530922889043962,-0.06931217634687514,0.4396993171296097,0.3568442088562379,0.6030704276412681,0.21963196721317674,5329]
["O15085-1","Rho guanine nucleotide exchange factor 11 [OS=Homo sapiens]",1,2,2,2,1522,167.6,5.5,5.16,"cell organization and biogenesis;signal transduction;other biological processes","other membranes;cytosol;other cell component","signal transduction activity or receptor binding;enzyme regulator activity","ARHGEF11","ENSG00000132694","Vascular smooth muscle contraction; Parathyroid hormone synthesis, secretion and action; Pathogenic Escherichia coli infection; Human cytomegalovirus infection; Pathways in cancer","RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOB GTPase cycle; Sema4D induced cell migration and growth-cone collapse","",155.1,161.7,170.1,161.6,166.3,260.6,0.827357689039932,-0.273416914656679,0.35669996438185764,0.4476969340279579,0.5568389661826137,0.25427038150459047,4682]
["O15091","Mitochondrial ribonuclease P protein 3 [OS=Homo sapiens]",19,10,14,10,583,67.3,8.78,42.78,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus","other molecular function","PRORP","ENSG00000100890","","tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion","",1292.5,1325.9,1322.9,1204.9,1384.1,807.2,1.1605029150226724,0.21475014653717503,0.3473822579060696,0.45919236634446686,0.5528014202123803,0.25743084987841736,4593]
["O15111","Inhibitor of nuclear factor kappa-B kinase subunit alpha [OS=Homo sapiens]",8,4,5,4,745,84.6,6.73,16.69,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","CHUK","ENSG00000213341","Antifolate resistance; MAPK signaling pathway; Ras signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; FoxO signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; TNF signaling pathway; Adipocytokine signaling pathway; Alcoholic liver disease; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Chagas disease; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Chemical carcinogenesis; Pancreatic cancer; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Constitutive Signaling by AKT1 E17K in Cancer; IKK complex recruitment mediated by RIP1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; AKT phosphorylates targets in the cytosol","Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Canonical and non-canonical Notch signaling; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Chemokine signaling pathway; IL-4 signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNAs involvement in the immune response in sepsis; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - interferon induction; Neuroinflammation; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; T-cell receptor (TCR) signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway",387,359.1,366,363.1,333.5,503.5,0.926672777268561,-0.1098681044205925,0.6100851482805276,0.21460954720613995,0.7230602154665763,0.1408255337484718,6167]
["O15116","U6 snRNA-associated Sm-like protein LSm1 [OS=Homo sapiens]",35,4,6,4,133,15.2,5.22,15.68,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","LSM1","ENSG00000175324","RNA degradation","mRNA decay by 5' to 3' exoribonuclease","",497.4,493.9,496,558.2,546.3,1157.9,0.6573992220650636,-0.6051583456847446,0.26987164085960413,0.568842750364863,0.5060266349519873,0.29582662326249265,3898]
["O15118","Niemann-Pick C1 protein [OS=Homo sapiens]",4,5,16,5,1278,142.1,5.36,47.77,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","NPC1","ENSG00000141458","Lysosome; Cholesterol metabolism","LDL clearance","Irinotecan pathway; Irinotecan pathway; Irinotecan pathway; Ebola virus pathway in host; Irinotecan pathway; Irinotecan pathway",1299,1407.2,1360.8,1239.9,1277.1,1189.6,1.09723196460368,0.1338685565582995,0.04073240345358847,1.3900599632055568,0.22020202429162586,0.657178692927201,1352]
["O15121","Sphingolipid delta(4)-desaturase DES1 [OS=Homo sapiens]",5,1,4,1,323,37.8,7.46,17.04,"cell organization and biogenesis;other metabolic processes;developmental processes","plasma membrane;other membranes;mitochondrion;ER/Golgi","other molecular function","DEGS1","ENSG00000143753","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway","Neutrophil degranulation; Sphingolipid de novo biosynthesis","Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway; Sphingolipid metabolism in senescence",247.1,287.5,289.7,240.3,276.3,244.9,1.0824688115561392,0.11432545815154194,0.3066944328818461,0.5132941072605464,0.5308144944194679,0.27505722680148115,4223]
["O15126-1","Secretory carrier-associated membrane protein 1 [OS=Homo sapiens]",12,4,6,4,338,37.9,7.42,21.87,"transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","SCAMP1","ENSG00000085365","","Neutrophil degranulation","",719.9,798.3,754.5,827.5,964.6,1194.7,0.7609146913084237,-0.39419337745968075,0.0954100021847778,1.0204060942062323,0.3312834707689031,0.4798002324939464,2105]
["O15127","Secretory carrier-associated membrane protein 2 [OS=Homo sapiens]",16,5,25,5,329,36.6,6.1,97.67,"transport","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","SCAMP2","ENSG00000140497","","","Serotonin transporter activity; Monoamine transport",2505.3,2471.4,2524.3,2190,2172.4,2220.4,1.1394847177492862,0.18838157596331173,1.2599234011989761E-4,3.8996558576188054,0.015877207136833302,1.79922588929777,58]
["O15143","Actin-related protein 2/3 complex subunit 1B [OS=Homo sapiens]",51,17,75,16,372,40.9,8.35,254.53,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","ARPC1B","ENSG00000130429","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling","Pathogenic Escherichia coli infection; Microglia pathogen phagocytosis pathway",13005.3,12973.7,13143.8,12658,12872.7,9442.8,1.118641256951692,0.16174744489615725,0.2809237358567472,0.5514115647638588,0.5148624837956282,0.288308752519504,3988]
["O15144","Actin-related protein 2/3 complex subunit 2 [OS=Homo sapiens]",67,19,142,19,300,34.3,7.36,398.24,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity","ARPC2","ENSG00000163466","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling","Pathogenic Escherichia coli infection",21304.4,21801.5,21895.3,19720,17620.2,12857.7,1.2948987905868574,0.3728393411361304,0.07269918535067202,1.1384704557116652,0.29340604402433007,0.5325309441417506,1811]
["O15145","Actin-related protein 2/3 complex subunit 3 [OS=Homo sapiens]",31,6,26,6,178,20.5,8.59,47.95,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity","ARPC3","ENSG00000111229","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection","Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling","Pathogenic Escherichia coli infection",2539,2834.8,2428.9,2440.7,3381.1,1933.8,1.0060730311001085,0.008735034548759731,0.9733051996483035,0.011750956504890645,0.9825811746173274,0.007631560818064585,7240]
["O15155","BET1 homolog [OS=Homo sapiens]",51,3,4,3,118,13.3,9.06,15.06,"cell organization and biogenesis;transport","other membranes;ER/Golgi","other molecular function","BET1","ENSG00000105829","SNARE interactions in vesicular transport","COPI-mediated anterograde transport; COPII-mediated vesicle transport","",197.2,222.3,211.7,209,215.8,338.3,0.8271524046651815,-0.2737749212376859,0.36072757077139905,0.4428206628485826,0.5572939790251862,0.2539156490131749,4731]
["O15156","Zinc finger and BTB domain-containing protein 7B [OS=Homo sapiens]",5,1,1,1,539,58,5.86,3.39,"RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZBTB7B","ENSG00000160685","","","Ectoderm differentiation; Ectoderm differentiation",17.5,19.9,15.6,14.9,15,26.6,0.9380530973451329,-0.09225850785198833,0.7890084206786167,0.10291836176555802,0.855236919285186,0.06791355955822515,6743]
["O15160","DNA-directed RNA polymerases I and III subunit RPAC1 [OS=Homo sapiens]",37,9,25,9,346,39.2,5.5,78.2,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR1C","ENSG00000171453","RNA polymerase; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","Pyrimidine metabolism; Cytosolic DNA-sensing pathway",1486.1,1493.7,1460.5,1537.9,1599.4,1806.7,0.8981189320388351,-0.15502159056532583,0.10977505545028962,0.9594963348498673,0.35021644709129934,0.45566346215529185,2291]
["O15162","phospholipid scramblase 1 [OS=Homo sapiens]",3,1,1,1,318,35,4.94,2.06,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","extracellular matrix;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;transporter activity;nucleic acid binding activity;other molecular function","PLSCR1","ENSG00000188313","","","EGF/EGFR signaling pathway; Complement system in neuronal development and plasticity",42.2,33.2,31.9,35.3,25.5,18.6,1.3513853904282118,0.4344391636135643,0.18576084960065944,0.7310458113004065,0.4336397475986011,0.3628709170333487,3131]
["O15164","Transcription intermediary factor 1-alpha [OS=Homo sapiens]",14,10,14,9,1050,116.8,7.11,36.53,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;kinase activity;other molecular function","TRIM24","ENSG00000122779","","Signaling by BRAF and RAF1 fusions; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease","",1096.2,1102.9,1097.9,1138,1105.9,2018.8,{"$f":"AVERAGE(S258:U258)/AVERAGE(V258:X258)","v":0.7734534449996483},{"$f":"LOG(Y258,2)","v":-0.370613637976403},{"$f":"TTEST(S258:U258,V258:X258,2,2)","v":0.34240828750847796},{"$f":"-LOG10(AA258)","v":0.46545573238377647},{"$f":"AA258*7309/AE258","v":0.5502775227351506},{"$f":"-LOG10(AC258)","v":0.2594182265155007},4548]
["O15173","Membrane-associated progesterone receptor component 2 [OS=Homo sapiens]",49,13,55,11,223,23.8,4.88,196.01,"transport;developmental processes;signal transduction","other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","PGRMC2","ENSG00000164040","","RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle","Ciliary landscape",5620.3,5806.7,5728.7,5516.9,5889.3,6640.6,0.9506228250991864,-0.07305505274420047,0.42517941816245075,0.37142776671416494,0.5930603754483497,0.22690109181391868,5240]
["O15182","Centrin-3 [OS=Homo sapiens]",15,3,3,3,167,19.5,4.74,7.09,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","CETN3","ENSG00000153140","","","Breast cancer pathway",261.2,303.6,273.7,397.5,471.3,230.9,0.7624806765481495,-0.3912273189000917,0.29432784944945245,0.5311686427933818,0.5235439892007905,0.2810468221712802,4109]
["O15211","Ral guanine nucleotide dissociation stimulator-like 2 [OS=Homo sapiens]",3,2,2,2,777,83.5,6.18,5.85,"signal transduction;other biological processes","cytosol","enzyme regulator activity","RGL2","ENSG00000206282; ENSG00000224841; ENSG00000228736; ENSG00000237441; ENSG00000237825","Ras signaling pathway","RAF/MAP kinase cascade","Ras signaling",133.7,123.9,124.5,153.2,163.6,520.7,0.45623880597014926,-1.1321389327623483,0.2774245540874129,0.5568551033465479,0.5120444610668942,0.2906923273880872,3960]
["O15213","WD repeat-containing protein 46 [OS=Homo sapiens]",21,11,15,11,610,68,9.67,46.35,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","WDR46","ENSG00000204221; ENSG00000206284; ENSG00000226916; ENSG00000227057; ENSG00000236222","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",829.8,868,828.1,1603.9,1703,2132.8,0.46434546022758605,-1.1067295647165019,3.9682802659857025E-3,2.401397662709216,0.07361462046723223,1.1330359226508175,394]
["O15226","NF-kappa-B-repressing factor [OS=Homo sapiens]",32,22,55,22,690,77.6,8.79,152.72,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","NKRF","ENSG00000186416","","","Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Network map of SARS-CoV-2 signaling pathway",5294.3,5008.4,5066,5878.1,5708.8,5687.8,0.8896652329707607,-0.168665520143083,0.003906215560693797,2.4082437942696937,0.0728329835028341,1.1376718994061776,392]
["O15228","Dihydroxyacetone phosphate acyltransferase [OS=Homo sapiens]",23,14,32,14,680,77.1,6.57,82.48,"cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;other cytoplasmic organelle","other molecular function","GNPAT","ENSG00000116906","Glycerophospholipid metabolism; Peroxisome","Peroxisomal protein import; Plasmalogen biosynthesis; Synthesis of PA","Triacylglyceride synthesis",3411.2,3299.4,3293.2,3477.7,2936.5,2952.2,1.068051759480697,0.09498156400739756,0.3077242339034409,0.5118383008402576,0.5317154670449762,0.27432070633132705,4230]
["O15229","Kynurenine 3-monooxygenase [OS=Homo sapiens]",8,3,4,3,486,55.8,9.03,13.58,"other metabolic processes;stress response;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion","other molecular function","KMO","ENSG00000117009","Tryptophan metabolism; Metabolic pathways; Biosynthesis of cofactors","Tryptophan catabolism","Selenium micronutrient network; NAD biosynthesis II (from tryptophan)",232.4,256.8,235.1,243,241.8,478.7,0.7517384535547483,-0.4116972912197561,0.37072199210364554,0.43095164983243334,0.5622757917172744,0.25005061424966885,4819]
["O15230","Laminin subunit alpha-5 [OS=Homo sapiens]",0,1,1,1,3695,399.5,7.02,3.56,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;other cell component","signal transduction activity or receptor binding;extracellular structural activity","LAMA5","ENSG00000130702","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Toxoplasmosis; Amoebiasis; Human papillomavirus infection; Pathways in cancer; Small cell lung cancer","Degradation of the extracellular matrix; ECM proteoglycans; Non-integrin membrane-ECM interactions; Interleukin-4 and Interleukin-13 signaling; Laminin interactions; MET activates PTK2 signaling","Alpha 6 beta 4 signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Complement system; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Inflammatory response pathway; Small cell lung cancer; Malignant pleural mesothelioma",19.6,10.9,22.4,14.3,20.3,64.6,0.5332661290322581,-0.9070723982728494,0.39562750814237463,0.40271351935214866,0.5752220921051554,0.24016444269625095,5027]
["O15234","Protein CASC3 [OS=Homo sapiens]",17,9,11,9,703,76.2,6.48,19.86,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","CASC3","ENSG00000108349","Nucleocytoplasmic transport; mRNA surveillance pathway","Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","",1406.7,1351.1,1351.9,2220.8,2193.9,2484.5,0.5956777597402598,-0.7473959993469412,5.987476559125857E-4,3.222756173829943,0.027351541356656805,1.5630181946018948,160]
["O15235","28S ribosomal protein S12, mitochondrial [OS=Homo sapiens]",30,3,14,3,138,15.2,10.29,40.07,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPS12","ENSG00000128626; ENSG00000283018","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1498.8,1520.7,1478.2,1434.4,1475.1,1304.3,1.0673738668185484,0.09406559446695122,0.14842637862517927,0.8284889085361306,0.4004608347624346,0.3974399516853258,2709]
["O15243","Leptin receptor gene-related protein [OS=Homo sapiens]",17,2,4,2,131,14.2,6.51,9.3,"transport;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","signal transduction activity or receptor binding","LEPROT","ENSG00000213625","","","",382.1,393,422,398.2,378.5,603.9,0.8670867738664348,-0.2057517162471055,0.44953048420883246,0.3472408519290267,0.6102560009439741,0.21448794126097412,5384]
["O15247","Chloride intracellular channel protein 2 [OS=Homo sapiens]",57,13,57,11,247,28.3,5.59,218.71,"other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","transporter activity;other molecular function","CLIC2","ENSG00000155962","","Stimuli-sensing channels; Ion homeostasis","",3220.7,3574.8,3267.8,3318.9,3663.7,3649.4,0.9465105342362677,-0.07930953232251182,0.29680705120179085,0.5275257857998401,0.5246342774447132,0.2801433378044326,4135]
["O15254","Peroxisomal acyl-coenzyme A oxidase 3 [OS=Homo sapiens]",24,12,20,12,700,77.6,7.25,66.46,"other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle","other molecular function","ACOX3","ENSG00000087008","Fatty acid degradation; beta-Alanine metabolism; alpha-Linolenic acid metabolism; Propanoate metabolism; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Carbon metabolism; Fatty acid metabolism; PPAR signaling pathway; cAMP signaling pathway; Peroxisome; Alcoholic liver disease","Peroxisomal protein import; Beta-oxidation of pristanoyl-CoA","PPAR signaling pathway; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Omega-3 / omega-6 fatty acid synthesis",1190.1,1175.8,1129,1130.5,1084.8,1461.4,0.9505534854625068,-0.07316028859156849,0.6403239986350244,0.19360022099412,0.7469084114304809,0.1267326496558334,6266]
["O15258","Protein RER1 [OS=Homo sapiens]",24,4,18,4,196,22.9,9.54,56.74,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding","RER1","ENSG00000157916","","","",2437.9,2384.9,2379.5,2359.5,2446.1,1686.1,1.1094628525655839,0.14986136350914311,0.3811956383947678,0.4188520771625709,0.5682559496282598,0.24545600852477617,4903]
["O15260-1","surfeit locus protein 4 [OS=Homo sapiens]",21,5,34,5,269,30.4,7.78,61.06,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","","SURF4","ENSG00000148248; ENSG00000280951; ENSGGOG00000014456; ENSNLEG00000013096; ENSPTRG00000021519","","COPI-dependent Golgi-to-ER retrograde traffic; Neutrophil degranulation","",2477.2,2601.2,2605.8,2093.7,2134.9,1342.3,1.3793462456694607,0.46398464989685145,0.0541683624845877,1.266254292983164,0.2536300841767146,0.5957992341616085,1561]
["O15264","Mitogen-activated protein kinase 13 [OS=Homo sapiens]",28,7,19,6,365,42.1,8.38,64.93,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","MAPK13","ENSG00000156711","Endocrine resistance; MAPK signaling pathway; Rap1 signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Oocyte meiosis; Cellular senescence; Adrenergic signaling in cardiomyocytes; VEGF signaling pathway; Osteoclast differentiation; Signaling pathways regulating pluripotency of stem cells; Platelet activation; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; TNF signaling pathway; Leukocyte transendothelial migration; Thermogenesis; Neurotrophin signaling pathway; Retrograde endocannabinoid signaling; Dopaminergic synapse; Inflammatory mediator regulation of TRP channels; GnRH signaling pathway; Progesterone-mediated oocyte maturation; Prolactin signaling pathway; Relaxin signaling pathway; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Alcoholic liver disease; Amyotrophic lateral sclerosis; Prion disease; Pathways of neurodegeneration; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Yersinia infection; Leishmaniasis; Chagas disease; Toxoplasmosis; Tuberculosis; Hepatitis B; Human cytomegalovirus infection; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Proteoglycans in cancer; Chemical carcinogenesis; PD-L1 expression and PD-1 checkpoint pathway in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","VEGFA-VEGFR2 Pathway; NOD1/2 Signaling Pathway; p38MAPK events; DSCAM interactions","Regulation of toll-like receptor signaling pathway; Parkinson's disease pathway; Retinoblastoma gene in cancer; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Angiopoietin-like protein 8 regulatory pathway; Oxidative damage response; Epithelial to mesenchymal transition in colorectal cancer; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Regulatory circuits of the STAT3 signaling pathway; Hepatitis B infection; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - apoptosis; Host-pathogen interaction of human coronaviruses - MAPK signaling; Toll-like receptor signaling pathway",1485.1,1427.1,1494.4,1598.6,1390.7,1556.8,0.9693143573612547,-0.044963474388803513,0.5252224271483767,0.2796567376876006,0.6654274085677736,0.1768993147617699,5769]
["O15269","serine palmitoyltransferase 1 [OS=Homo sapiens]",18,8,16,8,473,52.7,6.01,50.1,"other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","SPTLC1","ENSG00000090054","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway","Sphingolipid de novo biosynthesis","Sphingolipid pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway",1117.5,1183.3,1138.8,1210.2,1157.6,1512.7,0.8863806210539881,-0.17400175480771687,0.2608770197300162,0.5835641755720844,0.4984967678971734,0.30233765317774786,3825]
["O15270","Serine palmitoyltransferase 2 [OS=Homo sapiens]",11,5,12,5,562,62.9,7.78,29.59,"other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","SPTLC2","ENSG00000100596","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway","Sphingolipid de novo biosynthesis","Sphingolipid pathway; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway",585.8,561.2,583.9,586.7,582.6,993.7,0.8002311604253353,-0.3215112876037047,0.35111888464820945,0.45454581172533354,0.5545220241775634,0.2560812001210725,4628]
["O15287","Fanconi anemia group G protein [OS=Homo sapiens]",2,1,1,1,622,68.5,5.47,2.22,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus","nucleic acid binding activity","FANCG","ENSG00000221829","Fanconi anemia pathway","Fanconi Anemia Pathway","Retinoblastoma gene in cancer; DNA repair pathways, full network",27,24.8,23.9,26.2,31.8,37,0.7968421052631578,-0.32763421323257874,0.11899523735568306,0.9244704203850995,0.3626923226992025,0.4404616372639564,2398]
["O15294","UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit [OS=Homo sapiens]",12,12,22,12,1046,116.9,6.7,62.76,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component","other molecular function","OGT","ENSG00000147162","Other types of O-glycan biosynthesis; Insulin resistance","UCH proteinases; Regulation of necroptotic cell death; HATs acetylate histones","Ectoderm differentiation; Ectoderm differentiation",2483.2,2455.5,2473.1,3685.8,3531.2,4889.2,0.6122317490211626,-0.7078502330219493,0.02186819558028342,1.6601870506091787,0.16985615461880074,0.7699187121524628,941]
["O15297","protein phosphatase 1D [OS=Homo sapiens]",7,3,3,3,605,66.6,8.94,10.35,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus","kinase activity;other molecular function","PPM1D","ENSG00000170836","p53 signaling pathway","Transcriptional regulation by RUNX2","ATM signaling in development and disease ; Genotoxicity pathway",165.9,153.8,146.4,139.4,134.1,768.7,0.44722701976587986,-1.1609207418926049,0.41370439400554404,0.38330986638457704,0.5852071638835923,0.23269036604626578,5167]
["O15305","Phosphomannomutase 2 [OS=Homo sapiens]",44,12,65,11,246,28.1,6.77,167.72,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","PMM2","ENSG00000140650","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars","Defective PMM2 causes PMM2-CDG (CDG-1a); Synthesis of GDP-mannose","Nephrotic syndrome",8100.3,7815.7,7778.7,8350,8145.3,7184.9,1.0006123259094097,8.831291990534357E-4,0.9902880418251996,0.004238465220131523,0.9938233279830267,2.6908132904289693E-3,7283]
["O15315-1","Isoform 2 of DNA repair protein RAD51 homolog 2 [OS=Homo sapiens]",3,1,1,1,350,38.2,6.1,2.84,"","","","RAD51B","","","","",26.1,23.9,24.5,28.4,18.4,95.2,0.5246478873239436,-0.9305785990425206,0.4036370544218941,0.39400897179023564,0.5797176715994545,0.23678346077955736,5089]
["O15320","Endoplasmic reticulum export factor CTAGE5 [OS=Homo sapiens]",31,22,47,22,804,90.9,5.22,160.23,"","","","","","","","",5182.2,5516.7,5309,5428.3,5866.5,4146.1,1.036720657474629,0.0520272149169833,0.7371931659477263,0.1324186995041692,0.819614367190741,0.08639043736580186,6574]
["O15321-1","Transmembrane 9 superfamily member 1 [OS=Homo sapiens]",5,2,3,2,606,68.8,7.17,10.15,"other metabolic processes;other biological processes","other membranes;other cytoplasmic organelle;other cell component","","TM9SF1","ENSCANG00000029500; ENSCCAG00000032112; ENSG00000100926; ENSG00000285465; ENSPPAG00000042444; ENSPTRG00000032568; ENSRBIG00000029944; ENSRROG00000042511","","","",259.2,276.9,261.7,303.7,288.8,221.4,0.9802187000860056,-0.028824424915859004,0.8460571902985073,0.07260027928771104,0.8971176561572305,0.04715059589792486,6893]
["O15344-1","E3 ubiquitin-protein ligase Midline-1 [OS=Homo sapiens]",10,6,6,6,667,75.2,6.8,19.65,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","MID1","ENSCANG00000031338; ENSCCAG00000029160; ENSCJAG00000000987; ENSCSAG00000015273; ENSG00000101871; ENSMFAG00000037182; ENSMLEG00000034816; ENSMMUG00000020179; ENSMNEG00000026727; ENSPANG00000006683; ENSPPAG00000038224; ENSRBIG00000037000; ENSTSYG00000003295","Ubiquitin mediated proteolysis","Interferon gamma signaling","",371.2,362.2,368.2,346.4,354.8,455.9,0.9520352605652062,-0.07091308721495372,0.62776078701267,0.20220581593112297,0.7375508105249325,0.13220805538981958,6221]
["O15347","High mobility group protein B3 [OS=Homo sapiens]",23,4,6,3,200,23,8.37,19.09,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","HMGB3","ENSG00000029993","","","",323.3,348.8,537.8,480.5,412.6,797.5,0.7156630781970899,-0.4826475434512174,0.3057240233768145,0.5146704336649404,0.5296366169379325,0.27602199716284836,4219]
["O15355","Protein phosphatase 1G [OS=Homo sapiens]",51,23,124,23,546,59.2,4.36,418.89,"protein metabolism;other metabolic processes;other biological processes","other membranes;nucleus;other cell component","other molecular function","PPM1G","ENSG00000115241","","","VEGFA-VEGFR2 signaling pathway; mRNA processing",17103.8,16848.4,16835,16651.6,18717.2,16347.2,0.9820403743522312,-0.02614575600893948,0.700768196736305,0.1544256161655209,0.7915182738287209,0.10153905410375542,6471]
["O15357","Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 [OS=Homo sapiens]",25,21,39,20,1258,138.5,6.54,114.09,"cell adhesion;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","INPPL1","ENSG00000165458","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; B cell receptor signaling pathway; Fc gamma R-mediated phagocytosis; Insulin signaling pathway","Synthesis of PIPs at the plasma membrane; Interleukin receptor SHC signaling; Synthesis of IP3 and IP4 in the cytosol","EGF/EGFR signaling pathway; Insulin signaling",3064.3,2788.1,2911.7,2912.5,2956.6,3269,0.9590724548866831,-0.060288284485312094,0.41659239482190036,0.38028866265766953,0.5862290746540758,0.23193264606698044,5194]
["O15360","Fanconi anemia group A protein [OS=Homo sapiens]",2,2,2,2,1455,162.7,6.6,5.6,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","","FANCA","ENSG00000187741","Fanconi anemia pathway","Fanconi Anemia Pathway","DNA repair pathways, full network",150.3,118.7,139,164.3,174.6,214.2,0.7376604592297957,-0.43897118985706723,0.05313195781209013,1.2746441808656854,0.25086658892026276,0.6005571753285864,1548]
["O15371","Eukaryotic translation initiation factor 3 subunit D [OS=Homo sapiens]",58,23,96,23,548,63.9,6.05,317.05,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity","EIF3D","ENSG00000100353","","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","Translation factors; VEGFA-VEGFR2 signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell",8044.9,8038.1,8128.1,8291.1,8385.6,6068.7,1.0644394031320616,0.09009382175897873,0.5541210574221751,0.2563953456919506,0.6855231565163639,0.16397787044788956,5908]
["O15372","Eukaryotic translation initiation factor 3 subunit H [OS=Homo sapiens]",53,18,89,18,352,39.9,6.54,252.59,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3H","ENSG00000147677","Measles","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","Translation factors; VEGFA-VEGFR2 signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell",10696.6,10761.4,10870.5,11781.7,11401.3,13680.3,0.876983341155024,-0.18937865684825403,0.09920310191350759,1.003474747978301,0.3349078392082342,0.47507468678371234,2165]
["O15379","Histone deacetylase 3 [OS=Homo sapiens]",11,5,13,5,428,48.8,5.16,34.32,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","HDAC3","ENSG00000171720","Neutrophil extracellular trap formation; Thyroid hormone signaling pathway; Alcoholism; Viral carcinogenesis","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Regulation of PTEN gene transcription; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Cytoprotection by HMOX1; Association of TriC/CCT with target proteins during biosynthesis; NR1D1 (REV-ERBA) represses gene expression; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RUNX2 regulates osteoblast differentiation; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; STAT3 nuclear events downstream of ALK signaling","Neural crest differentiation; Initiation of transcription and translation elongation at the HIV-1 LTR; Ethanol effects on histone modifications; Transcription co-factors SKI and SKIL protein partners; 22q11.2 copy number variation syndrome; IL-18 signaling pathway; 7q11.23 copy number variation syndrome; 16p11.2 proximal deletion syndrome",1336,1349.2,1522.9,1539.3,1480,1855,0.8633239644666927,-0.21202605897625554,0.16538856295215737,0.781494526334291,0.41798928306269645,0.3788348530728113,2892]
["O15381-1","Nuclear valosin-containing protein-like [OS=Homo sapiens]",26,17,29,17,856,95,6.48,88.47,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","NVL","ENSG00000143748","Ribosome biogenesis in eukaryotes","","",2094.7,2127.7,2116.1,2484.4,2531,3403.3,0.7529072184541556,-0.4094560038590994,0.08121492312789487,1.090364162426057,0.309166600594679,0.5098074292456336,1920]
["O15382","Branched-chain-amino-acid aminotransferase, mitochondrial [OS=Homo sapiens]",49,14,34,14,392,44.3,8.65,113.66,"other metabolic processes;other biological processes","mitochondrion","other molecular function","BCAT2","ENSG00000105552","Cysteine and methionine metabolism; Valine, leucine and isoleucine degradation; Valine, leucine and isoleucine biosynthesis; Pantothenate and CoA biosynthesis; Metabolic pathways; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids; Biosynthesis of cofactors","Branched-chain amino acid catabolism","One-carbon metabolism and related pathways",4607.7,4766,4826.1,3826.9,4035.9,4161,1.1809744007718028,0.23997769269456035,3.4666917978499676E-3,2.4600847670666504,0.06811303857657369,1.1667697450645749,372]
["O15397-1","Importin-8 [OS=Homo sapiens]",10,8,19,7,1037,119.9,5.16,63.01,"transport;signal transduction","cytosol;nucleus","other molecular function","IPO8","ENSG00000133704","Nucleocytoplasmic transport","Transcriptional regulation by small RNAs","",926.1,962.4,989.4,1148.4,1290,1524.3,0.7262472556590205,-0.4614672880116447,0.031262684387239656,1.5049737337860452,0.19938827241390458,0.7003003895334433,1146]
["O15400","Syntaxin-7 [OS=Homo sapiens]",62,11,84,11,261,29.8,5.55,223.5,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","STX7","ENSG00000079950","SNARE interactions in vesicular transport; Phagosome","","",4099.5,4427.7,4164.1,4546.6,5216.7,6621.1,0.7745965674666145,-0.3684829866399577,0.11780142528434369,0.9288494549701313,0.3611621717295587,0.44229774415435713,2384]
["O15427","Monocarboxylate transporter 4 [OS=Homo sapiens]",3,2,4,2,465,49.4,7.96,10.11,"transport","plasma membrane;other membranes;nucleus;other cell component","transporter activity","SLC16A3","ENSG00000141526","Central carbon metabolism in cancer","Pyruvate metabolism; Basigin interactions; Proton-coupled monocarboxylate transport","Metabolic reprogramming in colon cancer",414.6,393.4,430.8,476.6,468.5,567.5,0.8189871744016924,-0.28808723590503293,0.05289316013424034,1.2766004850161161,0.25054835218481053,0.6011084491952914,1543]
["O15439-1","multidrug resistance-associated protein 4 [OS=Homo sapiens]",8,7,13,6,1325,149.4,8.19,35.69,"cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes","transporter activity;other molecular function","ABCC4","ENSG00000125257","Antifolate resistance; ABC transporters; cAMP signaling pathway; Bile secretion","ABC-family proteins mediated transport; Platelet degranulation","Fluoropyrimidine activity; Drug induction of bile acid pathway; Ectoderm differentiation; Pregnane X receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; TYROBP causal network in microglia; Aspirin and miRNAs; Proximal tubule transport; FOXA2 pathway; Prostaglandin synthesis and regulation",472.5,475.1,470,425.6,426.8,604.3,0.973158508958605,-0.03925328323792058,0.8370298262652888,0.07725906631780206,0.8903872798971031,0.05042105297473752,6871]
["O15446-1","DNA-directed RNA polymerase I subunit RPA34 [OS=Homo sapiens]",17,3,3,3,510,55,8.51,13.7,"RNA metabolism OR transcription;other metabolic processes;signal transduction","cytosol;mitochondrion;nucleus;other cell component","other molecular function","POLR1G","ENSG00000117877","RNA polymerase","B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","",31,37.3,57.4,66.1,46,54.9,0.7526946107784431,-0.4098634529409068,0.23508066491509041,0.6287830895734874,0.4774116643135304,0.32110697434242563,3599]
["O15498","Synaptobrevin homolog YKT6 [OS=Homo sapiens]",38,8,44,8,198,22.4,6.92,123.61,"cell organization and biogenesis;transport","plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","YKT6","ENSG00000106636","SNARE interactions in vesicular transport","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; COPI-mediated anterograde transport; RAC3 GTPase cycle; Intra-Golgi traffic; COPII-mediated vesicle transport","",6614.5,6945.4,6836.3,5781,6097,5020.4,1.206990010888605,0.2714137363239978,0.02510461520897697,1.6002464308878692,0.18060003204961877,0.7432821769517968,1016]
["O15504","nucleoporin-like protein 2 [OS=Homo sapiens]",7,2,4,2,423,44.8,9.19,8.16,"transport","other membranes;cytosol;nucleus","other molecular function","NUP42","ENSG00000136243","Nucleocytoplasmic transport","HCMV Early Events; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus","",165.3,174.2,181.4,204.4,190.6,228.6,0.8353110968569595,-0.25961449094708255,0.04673787293655678,1.3303310564482076,0.23526660695130408,0.6284397109283094,1452]
["O15511-1","Actin-related protein 2/3 complex subunit 5 [OS=Homo sapiens]",58,9,39,9,151,16.3,5.67,142.68,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity","Arpc5; ARPC5","ENSDLEG00000020693; ENSG00000162704; ENSGGOG00000007894; ENSPCTG00005002795; ENSPPAG00000038421; ENSPPYG00000000425; ENSPTRG00000001767; ENSRNOG00000028062; ENSSBOG00000027275; ENSSSCG00000015560; ENSSSCG00070012419; ENSSTOG00000001001","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection","Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; EPHB-mediated forward signaling; Neutrophil degranulation; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling","Pathogenic Escherichia coli infection; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton",4105.1,4190.1,4226.9,4410.4,4453.8,3513.1,1.0116988357719372,0.016779890030753836,0.8833288089993956,0.053877605196019245,0.9212685880388959,0.0356137364720706,7008]
["O15527-1","N-glycosylase/DNA lyase [OS=Homo sapiens]",3,1,1,1,345,38.8,8.6,3.08,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","OGG1","ENSG00000114026","Base excision repair","Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Displacement of DNA glycosylase by APEX1; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; Defective OGG1 Substrate Binding; Defective OGG1 Substrate Processing","Base excision repair; DNA repair pathways, full network",104.8,88.5,88.5,121,102,130.6,0.796945701357466,-0.3274466630817951,0.07503132033830094,1.1247574111322278,0.29820767827767347,0.5254811784863324,1839]
["O15530-1","3-phosphoinositide-dependent protein kinase 1 [OS=Homo sapiens]",25,10,18,10,556,63.1,7.36,46.45,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function","PDPK1","ENSG00000140992","Platinum drug resistance; PPAR signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Apoptosis; Axon guidance; Focal adhesion; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; Neurotrophin signaling pathway; Insulin signaling pathway; Thyroid hormone signaling pathway; Insulin resistance; Aldosterone-regulated sodium reabsorption; Toxoplasmosis; Proteoglycans in cancer; Chemical carcinogenesis; Endometrial cancer; Prostate cancer; Non-small cell lung cancer; Choline metabolism in cancer; Lipid and atherosclerosis","Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of TP53 Degradation; PIP3 activates AKT signaling; GPVI-mediated activation cascade; CD28 dependent PI3K/Akt signaling; G beta:gamma signalling through PI3Kgamma; RHO GTPases activate PKNs; Activation of AKT2; Integrin signaling; RSK activation; VEGFR2 mediated vascular permeability; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ","MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac hypertrophic response; Focal adhesion; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; PPAR signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; EGF/EGFR signaling pathway; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Modulators of TCR signaling and T cell activation; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway",2163.4,2134.3,2091.1,1819.7,1788.2,2346.4,1.0729724736744874,0.10161306528110879,0.4712995844302469,0.3267029431805938,0.6268841970155913,0.20281267805613026,5495]
["O15533-1","Tapasin [OS=Homo sapiens]",11,5,40,5,448,47.6,7.15,107.11,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;ER/Golgi","signal transduction activity or receptor binding;transporter activity;other molecular function","TAPBP","ENSG00000112493; ENSG00000206208; ENSG00000206281; ENSG00000231925; ENSG00000236490; ENSPPAG00000024524; ENSPTRG00000018043","Antigen processing and presentation; Human cytomegalovirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection","ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC","",4691.5,4790.5,4806,4419.3,4543.7,7375.9,0.874477474003758,-0.19350687318941312,0.5182447807915206,0.28546506296271945,0.6599043733110146,0.18051899347672004,5740]
["O15534-1","period circadian protein homolog 1 [OS=Homo sapiens]",2,2,2,2,1290,136.1,6.09,0,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PER1","ENSG00000179094","Circadian rhythm; Circadian entrainment","Circadian Clock","Melatonin metabolism and effects; Exercise-induced circadian regulation",179.8,184.6,206,132.4,132.6,290.1,1.0275626013330932,0.039226288682305606,0.9281676487121369,0.03237357298944601,0.9526720045551198,0.021056596875271925,7121]
["O15541","RING finger protein 113A [OS=Homo sapiens]",29,7,14,7,343,38.8,5.69,43.22,"protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus","other molecular function","RNF113A","ENSG00000125352","","","",1331,1280.1,1411.5,1317.8,1347.3,1185,1.0448040310641282,0.06323236821540444,0.41226445423365043,0.3848241087971642,0.5840746067055148,0.23353167478649958,5159]
["O15550","Lysine-specific demethylase 6A [OS=Homo sapiens]",3,4,5,4,1401,154.1,7.44,12.76,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","KDM6A","ENSG00000147050","Transcriptional misregulation in cancer","Activation of anterior HOX genes in hindbrain development during early embryogenesis; HDMs demethylate histones","Mesodermal commitment pathway; Mesodermal commitment pathway; Pathways affected in adenoid cystic carcinoma",606,614.4,589.7,676.6,656.1,724.5,0.8798852809644178,-0.1846126567879578,0.0186719434105252,1.7288104775226705,0.1577725253035014,0.8019686231035117,865]
["O15553","Pyrin [OS=Homo sapiens]",2,2,5,1,781,86.4,8.03,11.75,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","MEFV","ENSG00000103313","NOD-like receptor signaling pathway; Yersinia infection","The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection","Nucleotide-binding oligomerization domain (NOD) pathway",229.3,223.4,226.4,254.3,282.6,239.4,0.8747906737086177,-0.1929902552352951,0.06435000152639747,1.191451438458025,0.2745675196476586,0.5613508395395627,1713]
["O43143","Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 [OS=Homo sapiens]",41,32,171,32,795,90.9,7.46,501.7,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","DHX15","ENSG00000109606","Spliceosome","mRNA Splicing - Major Pathway","mRNA processing",19092.5,19148.3,19722.2,18872.9,18753.7,13842.8,1.1261642840211852,0.1714173020666956,0.2645038456950125,0.5775680092545744,0.5016239253204064,0.2996217576900356,3854]
["O43148-1","mRNA cap guanine-N7 methyltransferase [OS=Homo sapiens]",41,18,47,18,476,54.8,6.61,140.64,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RNMT","ENSG00000101654","mRNA surveillance pathway","RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE","mRNA processing",5429.2,5567.8,5359,6097.7,6281.2,4832.5,0.9503003823047513,-0.07354448506124672,0.5685331305586896,0.245244222269862,0.6963982991877765,0.15714229822998702,5967]
["O43149","Zinc finger ZZ-type and EF-hand domain-containing protein 1 [OS=Homo sapiens]",14,33,57,21,2961,330.9,5.95,161.32,"","","other molecular function","ZZEF1","ENSG00000074755","","","",4702.4,4686.8,4671.9,4537.7,4605.1,6038.2,0.926230156116198,-0.11055736594870345,0.48810206024903213,0.3114893592090849,0.6378576717969204,0.19527621665336015,5593]
["O43149-3","Isoform 3 of Zinc finger ZZ-type and EF-hand domain-containing protein 1 [OS=Homo sapiens]",13,13,25,1,1085,119.9,5.67,74.37,"","","","ZZEF1","","","","",306.4,306.7,285.6,287.9,288.2,382.2,0.937806532401127,-0.09263776653252301,0.5700761638022918,0.24406711746903106,0.6973534194528788,0.15654706520523337,5975]
["O43150-1","Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 [OS=Homo sapiens]",4,3,4,3,1006,111.6,6.68,13.77,"other biological processes","plasma membrane;other membranes;ER/Golgi","enzyme regulator activity;other molecular function","ASAP2","ENSG00000151693","Endocytosis; Fc gamma R-mediated phagocytosis","","Vitamin D receptor pathway",105.7,118.7,103.4,96.9,128.8,152.6,0.866508062384351,-0.20671492194991734,0.373665994730846,0.42751642308351573,0.5638160106291811,0.24886259567055746,4844]
["O43156","TELO2-interacting protein 1 homolog [OS=Homo sapiens]",7,7,9,7,1089,122,5.97,19.69,"other biological processes","nucleus;other cell component","","TTI1","ENSG00000101407","mTOR signaling pathway","","Fragile X syndrome; Malignant pleural mesothelioma",1036.2,973.2,978.2,1082.4,997.3,1155.1,0.923581056015828,-0.11468951323517687,0.1738929400388161,0.7597180497651129,0.4255050213403773,0.3710953104852682,2987]
["O43159","ribosomal rna-processing protein 8 [OS=Homo sapiens]",19,8,22,8,456,50.7,9.42,54.26,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","RRP8","ENSG00000132275","","SIRT1 negatively regulates rRNA expression","",2016.4,1905.5,1929.5,2255.8,2264.5,1651.7,0.9480557355800387,-0.07695621816755455,0.6306733593776012,0.2001955138927807,0.7390719229903618,0.13131329605993938,6237]
["O43164","E3 ubiquitin-protein ligase Praja-2 [OS=Homo sapiens]",3,1,2,1,708,78.2,4.39,6.64,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component","other molecular function","PJA2","ENSG00000198961","","Antigen processing: Ubiquitination & Proteasome degradation","",51.3,45.8,50.3,84.8,77.9,81.1,0.604593929450369,-0.7259616015251427,2.5173742512533677E-4,3.599052214260241,0.019999443915663984,1.6989820797218231,92]
["O43166-1","Signal-induced proliferation-associated 1-like protein 1 [OS=Homo sapiens]",1,2,2,2,1804,199.9,8.19,0,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;enzyme regulator activity","SIPA1L1","ENSG00000197555","Rap1 signaling pathway","Neurexins and neuroligins","",93.3,91,87.1,92.2,93.8,278.1,0.5847877612583493,-0.7740149767513382,0.3568295009704313,0.4475392474040078,0.5568033353101799,0.2542981719203603,4684]
["O43169","Cytochrome b5 type B [OS=Homo sapiens]",55,5,29,5,146,16.3,4.97,98.99,"","other membranes","other molecular function","","","","","",2806,2703.1,2894.2,2621.4,2054.7,2395.4,1.188333451177261,0.24893971901631706,0.06293622391883741,1.201099317673321,0.2713869384205207,0.566411058328449,1695]
["O43172-1","U4/U6 small nuclear ribonucleoprotein Prp4 [OS=Homo sapiens]",43,19,56,1,522,58.4,7.42,166.66,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity","PRPF4","ENSG00000136875; ENSPTRG00000021274","Spliceosome","mRNA Splicing - Major Pathway","mRNA processing; mRNA Processing",162.5,155.2,147.4,171.4,201.6,210.2,0.7974965706447188,-0.3264497798023257,0.034928495314631644,1.4568201229403046,0.2075547741907664,0.6828672724957295,1230]
["O43172-2","Isoform 2 of U4/U6 small nuclear ribonucleoprotein Prp4 [OS=Homo sapiens]",43,19,57,1,521,58.3,7.42,168.72,"","","","PRPF4","","","","",7020,6874.5,6858.5,7079.9,7108.6,7296.6,0.9659252225961248,-0.05001658819220817,0.04571939290437927,1.3398995451190259,0.23270406875912816,0.6331960231413346,1436]
["O43175","D-3-phosphoglycerate dehydrogenase [OS=Homo sapiens]",43,18,195,18,533,56.6,6.71,658.6,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytosol","other molecular function","PHGDH","ENSG00000092621","Glycine, serine and threonine metabolism; Cysteine and methionine metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids","Serine biosynthesis","Trans-sulfuration and one-carbon metabolism; Clear cell renal cell carcinoma pathways; Neuroinflammation and glutamatergic signaling",13976.6,14336.1,13946.2,15590.3,16148.3,18313.5,0.8442982412326356,-0.24417538606919645,0.036469836906519774,1.4380661788512001,0.20972308257258304,0.6783537675212353,1271]
["O43181","NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [OS=Homo sapiens]",23,4,8,4,175,20.1,10.3,15.99,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity","NDUFS4","ENSG00000164258","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",1093.1,1067.7,1103.7,1026.4,1052,514.3,{"$f":"AVERAGE(S322:U322)/AVERAGE(V322:X322)","v":1.2591121224977824},{"$f":"LOG(Y322,2)","v":0.33240675912452344},{"$f":"TTEST(S322:U322,V322:X322,2,2)","v":0.2709007929221816},{"$f":"-LOG10(AA322)","v":0.5671897237921397},{"$f":"AA322*7309/AE322","v":0.5071756904375577},{"$f":"-LOG10(AC322)","v":0.2948415709028209},3904]
["O43182","Rho GTPase-activating protein 6 [OS=Homo sapiens]",7,6,7,6,974,105.9,7.36,16.39,"cell adhesion;cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","ARHGAP6","ENSG00000047648","","RHOA GTPase cycle; RAC3 GTPase cycle","",349.8,333.3,372,395,386,383.3,0.9062097397577944,-0.14208309816014122,0.03635814590905198,1.439398271819667,0.209906546958342,0.6779740156170302,1266]
["O43189-2","Isoform 1 of PHD finger protein 1 [OS=Homo sapiens]",18,5,10,5,457,49.6,7.93,27.84,"","","","PHF1","","","","",601.6,573.1,547.6,557.8,567.8,885,0.8566099671739781,-0.22328963093320053,0.42606161558258693,0.37052759016370496,0.593724375270377,0.2264151208093087,5245]
["O43237","Cytoplasmic dynein 1 light intermediate chain 2 [OS=Homo sapiens]",18,7,14,7,492,54.1,6.38,47.14,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","DYNC1LI2","ENSG00000135720","Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection","Separation of Sister Chromatids; COPI-mediated anterograde transport; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Intraflagellar transport proteins binding to dynein",1344.1,1320.8,1307.1,1491.6,1411.1,1674.7,0.867741512649102,-0.20466274571668253,0.06244124750103404,1.2045284288414726,0.2702090455802592,0.5683001165285083,1689]
["O43242","26S proteasome non-ATPase regulatory subunit 3 [OS=Homo sapiens]",57,29,211,29,534,60.9,8.44,648.47,"protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","enzyme regulator activity","PSMD3","ENSG00000108344","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Interleukin-1 signaling; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease",19527.7,19670,19563,20029,19359.3,19592,0.9962767229057836,-5.3815781816448525E-3,0.7340449527777528,0.13427734315541792,0.8176066077190789,0.08745560732147382,6562]
["O43251-1","RNA binding protein fox-1 homolog 2 [OS=Homo sapiens]",2,1,1,1,390,41.3,7.27,2.16,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RBFOX2","ENSG00000100320; ENSG00000277564","","FGFR2 alternative splicing","Mammalian disorder of sexual development",54.3,52.3,50,70.1,58.5,752,0.1778332954803543,-2.491402631645853,0.35188485150494697,0.4535994289574149,0.5547727307268459,0.2558848943650003,4636]
["O43252","bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [OS=Homo sapiens]",52,24,106,22,624,70.8,6.86,321.71,"other metabolic processes;developmental processes","cytosol","kinase activity;other molecular function","PAPSS1","ENSG00000138801","Purine metabolism; Selenocompound metabolism; Sulfur metabolism; Metabolic pathways","Signaling by BRAF and RAF1 fusions; Transport and synthesis of PAPS; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se","Sulfation biotransformation reaction",11259.4,11398.1,11194,11694.8,11725.5,12200.6,0.9503269148168632,-0.07350420538757634,0.027752345381795628,1.5567003082771735,0.1890418382064718,0.7234420683591516,1073]
["O43264","Centromere/kinetochore protein zw10 homolog [OS=Homo sapiens]",36,19,56,19,779,88.8,6.27,186.12,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","nucleic acid binding activity","ZW10","ENSG00000086827","","COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",3120.1,3169.1,3148.7,2982.9,3055.2,1988.2,1.1758718213871897,0.23373080445349284,0.24379428089982982,0.612976486587933,0.48473677886203925,0.3144940274180337,3676]
["O43278","Kunitz-type protease inhibitor 1 [OS=Homo sapiens]",17,9,13,9,529,58.4,6.29,35.9,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes","enzyme regulator activity","SPINT1","ENSG00000166145","Transcriptional misregulation in cancer; Prostate cancer","MET Receptor Activation; Signaling by MST1","",1379.1,1404.3,1498.2,1451.6,1433.4,3188.7,0.7049409750234618,-0.504425629724687,0.36361106479742134,0.4393629095332712,0.5592662610699395,0.25238137962243534,4752]
["O43283","Mitogen-activated protein kinase kinase kinase 13 [OS=Homo sapiens]",2,1,1,1,966,108.2,6.49,0,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;other cell component","kinase activity;other molecular function","MAP3K13","ENSG00000073803","MAPK signaling pathway","","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Insulin signaling",236.4,284,285.7,203.3,270.6,49.8,1.5392400229138816,0.6222182172849708,0.23449557040482963,0.6298653566457386,0.4770186819061786,0.3214646119664152,3593]
["O43290","U4/U6.U5 tri-snRNP-associated protein 1 [OS=Homo sapiens]",56,39,111,39,800,90.2,6.13,371.13,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","","SART1","ENSG00000175467","Spliceosome","mRNA Splicing - Major Pathway","",10796.7,11026.4,11112.2,11840.3,12343.4,13451.8,0.8751125931633698,-0.19245944691580916,0.032012729855123156,1.4946772902274343,0.20118748281263557,0.6963990430719098,1163]
["O43291","Kunitz-type protease inhibitor 2 [OS=Homo sapiens]",13,3,3,3,252,28.2,8.29,4.49,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","enzyme regulator activity","SPINT2","ENSG00000167642","","MET Receptor Activation; Signaling by MST1","",338.2,363.4,383.9,385.9,378.6,1264.5,0.5349926071956629,-0.9024091391415145,0.3455620141825881,0.46147400328103594,0.5519477188943479,0.25810205718203083,4576]
["O43292-1","Glycosylphosphatidylinositol anchor attachment 1 protein [OS=Homo sapiens]",10,6,10,6,621,67.6,8.06,27.83,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi","cytoskeletal activity","GPAA1","ENSG00000197858","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways","Attachment of GPI anchor to uPAR","",1367.1,1426.4,1445.1,1107.1,1215.3,1366.1,1.1491392164836658,0.20055358890130376,0.08025017011063716,1.0955540383245517,0.307737929348713,0.5118189727428862,1906]
["O43298","Zinc finger and BTB domain-containing protein 43 [OS=Homo sapiens]",2,1,1,1,467,52.6,5.76,2.49,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB43","ENSG00000169155","","","",70.9,70.1,69.6,37.7,57.2,0.6,2.205235602094241,1.1409327981026063,0.0819772012784886,1.0863069126852496,0.31029071162323835,0.5082312245806714,1931]
["O43299","AP-5 complex subunit zeta-1 [OS=Homo sapiens]",3,2,2,2,807,88.5,7.01,4.08,"DNA metabolism;stress response;transport","other membranes;nucleus;other cell component","","AP5Z1","ENSG00000242802","","","",109.6,91.2,103.7,143.6,110.1,1476.2,0.17602173536042545,-2.5061745094305357,0.3505105602834394,0.4552988929505719,0.5541600011057016,0.2563648245046807,4623]
["O43301","Heat shock 70 kDa protein 12A [OS=Homo sapiens]",2,1,4,1,675,74.9,6.77,0,"","nucleus;other cell component","other molecular function","HSPA12A","ENSG00000165868","","Regulation of HSF1-mediated heat shock response","",209,252.5,265.4,72.2,126.1,3.4,3.603867129400099,1.849545821559541,0.01129873791131725,1.946970065256609,0.12144481675561439,0.9156210160788725,680]
["O43303","centriolar coiled-coil protein of 110 kDa [OS=Homo sapiens]",12,9,9,8,1012,113.4,8.65,21.8,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;other cell component","","CCP110","ENSG00000103540","","Ub-specific processing proteases; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; RHOV GTPase cycle","Genotoxicity pathway; Joubert syndrome",624,623.9,608.2,722.8,782.8,808.7,0.8020135678174826,-0.3183014516517722,0.004181104766440205,2.3787089501446768,0.07453584082417429,1.1276348449804394,410]
["O43310","CBP80/20-dependent translation initiation factor [OS=Homo sapiens]",15,6,7,1,598,67.5,6.54,17.4,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity","CTIF","ENSG00000134030; ENSG00000282825","","","",377.2,343,409.5,489.9,442.7,1097.1,0.5565847169532444,-0.8453268000850279,0.22919864644860896,0.6397879514587308,0.4726898721481047,0.32542370278977095,3544]
["O43310-2","Isoform 2 of CBP80/20-dependent translation initiation factor [OS=Homo sapiens]",15,6,7,1,600,67.7,6.54,15.96,"","","","CTIF","","","","",26.4,24.2,24.5,38,23.5,210.6,0.27600147004777653,-1.8572521437354068,0.3359514808810758,0.47372344019096874,0.5457811455345151,0.26298147147256257,4499]
["O43314-1","inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 [OS=Homo sapiens]",15,16,30,13,1243,140.3,8.22,88.09,"other metabolic processes;other biological processes","cytosol","kinase activity;other molecular function","PPIP5K2","ENSG00000145725","Phosphatidylinositol signaling system","Synthesis of pyrophosphates in the cytosol","",2785.6,2798.4,2867.1,2710.5,2746.6,2651.8,1.042200545080097,0.05963291442455523,0.03822092519033549,1.4176988044554106,0.2143950439110991,0.6687852582840224,1303]
["O43318","mitogen-activated protein kinase kinase kinase 7 [OS=Homo sapiens]",3,2,2,2,606,67.2,7.11,3.79,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle","signal transduction activity or receptor binding;kinase activity;other molecular function","MAP3K7","ENSG00000135341","MAPK signaling pathway; NF-kappa B signaling pathway; Autophagy; AMPK signaling pathway; Wnt signaling pathway; Osteoclast differentiation; Adherens junction; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; IL-17 signaling pathway; T cell receptor signaling pathway; TNF signaling pathway; Alcoholic liver disease; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Leishmaniasis; Toxoplasmosis; Hepatitis B; Measles; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Ca2+ pathway; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; TNFR1-induced NFkappaB signaling pathway; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway","Regulation of toll-like receptor signaling pathway; IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; Fas ligand pathway and stress induction of heat shock proteins; Wnt signaling pathway; IL-6 signaling pathway; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Angiopoietin-like protein 8 regulatory pathway; Wnt signaling pathway and pluripotency; p38 MAPK signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; miRNAs involvement in the immune response in sepsis; Signal transduction through IL1R; Hepatitis B infection; IL-18 signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - interferon induction; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway",113.9,125.3,111.1,141.2,128.3,97.7,0.9539760348583878,-0.06797507061174507,0.7001819519408035,0.15478908790622836,0.7909783441631116,0.10183540669095581,6470]
["O43324-1","Eukaryotic translation elongation factor 1 epsilon-1 [OS=Homo sapiens]",53,8,37,8,174,19.8,8.54,111.53,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","EEF1E1","ENSANAG00000036153; ENSG00000124802; ENSPTRG00000017709","","Selenoamino acid metabolism; Cytosolic tRNA aminoacylation","",5099.3,5232,4779.5,5300,5283.6,2630.4,1.1435447252913575,0.19351279224211407,0.5198817401334661,0.2840954360739033,0.6609524506236744,0.1798297828359052,5749]
["O43353-1","Receptor-interacting serine/threonine-protein kinase 2 [OS=Homo sapiens]",10,4,5,4,540,61.2,7.09,10.76,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","RIPK2","ENSG00000104312","NOD-like receptor signaling pathway; Neurotrophin signaling pathway; Shigellosis; Salmonella infection; Tuberculosis","Downstream TCR signaling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; p75NTR recruits signalling complexes; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; activated TAK1 mediates p38 MAPK activation; Ovarian tumor domain proteases","Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Fas ligand pathway and stress induction of heat shock proteins; T-cell receptor (TCR) signaling pathway",232.2,245.6,232.4,260.4,227.8,276.2,0.9290947148090005,-0.10610241795648495,0.2926810352355432,0.53360541750263,0.5230331751923191,0.2814707636259989,4090]
["O43379-4","Isoform 4 of WD repeat-containing protein 62 [OS=Homo sapiens]",7,10,16,10,1523,166.4,5.88,35.16,"","","","WDR62","","","","",1247,1216.3,1187.6,1240.3,1151.1,1239.4,1.0055359700341522,0.007964690655406594,0.854217454488556,0.06843155874551225,0.9031499168026697,0.04424015374397268,6913]
["O43390-1","heterogeneous nuclear ribonucleoprotein r [OS=Homo sapiens]",58,32,239,23,633,70.9,8.13,774.29,"RNA metabolism OR transcription;other metabolic processes;other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity","Hnrnpr; HNRNPR; LOC111154612","ENSAMEG00000009537; ENSCAFG00000013308; ENSCANG00000026442; ENSCATG00000035305; ENSFCAG00000019123; ENSG00000125944; ENSG00000282958; ENSGGOG00000013250; ENSLCNG00005013650; ENSMFAG00000039737; ENSMMUG00000010970; ENSMPUG00000015898; ENSNLEG00000008411; ENSRROG00000036942; ENSSSUG00005005658; ENSUAMG00000027050; ENSUMAG00000013292","","mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA","mRNA Processing; mRNA processing",25540,25367.5,25386.2,30181.9,28766.6,24215.1,0.9173929459523157,-0.12438828064248122,0.27242262630103325,0.5647568245507357,0.5070376815977214,0.29495976393718104,3927]
["O43395","U4/U6 small nuclear ribonucleoprotein Prp3 [OS=Homo sapiens]",42,24,72,24,683,77.5,9.5,192.25,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","other molecular function","PRPF3","ENSG00000117360","Spliceosome","mRNA Splicing - Major Pathway","mRNA processing",8466.5,8277.8,8414.5,9392.2,9415.7,8312.7,0.9276638422453779,-0.10832598456129071,0.15032778495689286,0.8229607417135799,0.40291374413272096,0.39478791777123684,2727]
["O43396","Thioredoxin-like protein 1 [OS=Homo sapiens]",59,13,79,13,289,32.2,4.96,327.32,"","cytosol;nucleus;other cell component","other molecular function","TXNL1","ENSG00000091164","","RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle","",9358,9264,9353,8421.9,8617.9,6289.4,1.1991409906897794,0.2620012956250146,0.10661172204868977,0.9721950416398192,0.34509525086531156,0.46206101734479527,2258]
["O43399","Tumor protein D54 [OS=Homo sapiens]",60,11,30,11,206,22.2,5.36,92.73,"other metabolic processes;other biological processes","other cell component","other molecular function","TPD52L2","ENSG00000101150","","","",2837.7,2799,2529.8,2426.5,2858.8,2903.4,0.9972889469634982,-0.003916534139305457,0.9692269068890811,0.013574537836997627,0.9799528928554839,0.00879480069999403,7229]
["O43402","ER membrane protein complex subunit 8 [OS=Homo sapiens]",29,5,10,5,210,23.8,6.4,41.53,"cell organization and biogenesis","other membranes;cytosol;ER/Golgi;other cell component","","EMC8","ENSG00000131148","","","",1153,1114.1,1100.6,1071.4,1102,659.6,1.1887398517472643,0.24943302487436483,0.2820757071033374,0.5496343145013571,0.5151652531779843,0.28805343691757673,4002]
["O43414-1","ERI1 exoribonuclease 3 [OS=Homo sapiens]",3,1,3,1,337,37.2,8.07,8.56,"RNA metabolism OR transcription;other metabolic processes","","nucleic acid binding activity;other molecular function","ERI3","ENSG00000117419; ENSMFAG00000044436; ENSMLEG00000012810; ENSMMUG00000011651; ENSMNEG00000035539; ENSNLEG00000014004; ENSPANG00000013867; ENSPPAG00000042776; ENSPTRG00000000655; ENSRBIG00000044795; ENSRROG00000036414","","","",642.1,613.3,584.3,629.2,593.6,494.2,1.0714618520675596,0.09958048574691221,0.4023570926721708,0.3953883386113249,0.5790171274543997,0.23730858955594963,5079]
["O43422-1","52 kDa repressor of the inhibitor of the protein kinase [OS=Homo sapiens]",16,7,11,7,761,87.6,5.86,27.98,"other metabolic processes;signal transduction;other biological processes","","nucleic acid binding activity;kinase activity;other molecular function","THAP12","ENSG00000137492; ENSPTRG00000004091","","","",491.9,432.4,435.9,363.3,392,274.4,1.3209672720209769,0.4015947231495077,0.05227434039660389,1.2817114384514185,0.2497210156593319,0.6025449073850445,1530]
["O43426","Synaptojanin-1 [OS=Homo sapiens]",7,9,12,9,1573,173,7.42,33.23,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity;other molecular function","SYNJ1","ENSG00000159082","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; Synthesis of IP3 and IP4 in the cytosol; Synthesis of IP2, IP, and Ins in the cytosol","VEGFA-VEGFR2 signaling pathway; EGF/EGFR signaling pathway",1026.2,990.8,1035.4,1013.9,1081.3,1042.3,0.9728764940239045,-0.03967142736171448,0.2992164710815733,0.5240145033779323,0.5252096991198894,0.2796672623324579,4164]
["O43427","Acidic fibroblast growth factor intracellular-binding protein [OS=Homo sapiens]",23,9,17,9,364,41.9,6.48,41.38,"signal transduction","other membranes;mitochondrion;nucleus;other cell component","other molecular function","FIBP","ENSG00000172500","","","Modulators of TCR signaling and T cell activation",2142.7,2033.7,2073.9,2162.2,2092.2,1377.9,1.1097242689487419,0.15020125744388832,0.4605425848855043,0.33673020580219676,0.6192247521942883,0.20815169197868044,5436]
["O43432","Eukaryotic translation initiation factor 4 gamma 3 [OS=Homo sapiens]",15,23,56,17,1585,176.5,5.38,136.67,"protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus","nucleic acid binding activity","EIF4G3","ENSG00000075151","Viral myocarditis","ISG15 antiviral mechanism","Translation factors; Translation inhibitors in chronically activated PDGFRA cells",2372.1,2210,2343.3,2511.6,2561.4,2319.5,0.9368143388569496,-0.09416493702485879,0.15533443448774797,0.8087322593370166,0.40736970996446,0.3900112661663479,2787]
["O43447","peptidyl-prolyl cis-trans isomerase H [OS=Homo sapiens]",47,8,66,7,177,19.2,8.07,156.88,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","PPIH","ENSG00000171960","Spliceosome","mRNA Splicing - Major Pathway","",6151.5,5947.5,5908.9,6010.3,6148.1,6364,0.9722228220964886,-0.04064109433525903,0.24982955463016943,0.602356186243877,0.49112539397307914,0.30880760979578387,3718]
["O43463","Histone-lysine N-methyltransferase SUV39H1 [OS=Homo sapiens]",8,3,4,3,412,47.9,8.03,9.35,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SUV39H1","ENSG00000101945","Lysine degradation; Metabolic pathways","PKMTs methylate histone lysines; SIRT1 negatively regulates rRNA expression","Histone modifications; Retinoblastoma gene in cancer; Interactions between LOXL4 and oxidative stress pathway; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome",187,218.2,222.2,263.5,291.9,215.6,0.8137483787289235,-0.2973453309587938,0.12681303559801546,0.8968361013651402,0.3706023499343843,0.4310918312116698,2501]
["O43464","Serine protease HTRA2, mitochondrial [OS=Homo sapiens]",30,9,36,9,458,48.8,10.07,113.17,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","HTRA2","ENSG00000115317","Apoptosis; Apoptosis; Parkinson disease; Pathways of neurodegeneration","","Parkinson's disease pathway; Nanomaterial induced apoptosis; Ciliary landscape; Complement system in neuronal development and plasticity",2170,2080.4,2116.6,1957.7,2058.9,1810.7,1.092615791189745,0.1277861790605941,0.07866514244692156,1.1042176665796943,0.3053444111229685,0.5152100247123861,1883]
["O43488","aflatoxin B1 aldehyde reductase member 2 [OS=Homo sapiens]",39,11,37,11,359,39.6,7.17,96.56,"other metabolic processes","cytosol;ER/Golgi","other molecular function","AKR7A2","ENSG00000053371","Metabolism of xenobiotics by cytochrome P450","Aflatoxin activation and detoxification","Aflatoxin B1 metabolism; Metapathway biotransformation Phase I and II",5069.5,5045.3,5119.1,4891.3,5124.2,4580.6,1.0436966038873396,0.06170239037474856,0.2520360037850591,0.5985374150585627,0.4934720470573257,0.30673744310089424,3733]
["O43491-1","band 4.1-like protein 2 [OS=Homo sapiens]",48,43,149,40,1005,112.5,5.44,466.01,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","EPB41L2","ENSG00000079819","","Neurexins and neuroligins","Splicing factor NOVA regulated synaptic proteins",16617.5,16577.3,16855.8,15141.3,15325.6,14363.1,1.1164532679009593,0.15892286461444718,4.805078746237851E-3,2.318299490664252,0.07927837597348183,1.1008452550033485,443]
["O43493-1","Trans-Golgi network integral membrane protein 2 [OS=Homo sapiens]",37,16,34,2,480,51.1,5.73,98.24,"","","","","","","","",3370.1,3284.6,3692.7,5425.7,5494.7,3340.7,0.72556815392922,-0.46281695927539784,0.14322515844714284,0.8439806886267405,0.3933982273920206,0.4051676012941564,2661]
["O43493-4","Isoform 4 of Trans-Golgi network integral membrane protein 2 [OS=Homo sapiens]",44,15,33,1,379,39.5,5.59,87.4,"","","","TGOLN2","","","","",448.6,435,444.1,741,712.3,783,0.5937038858829315,-0.7521845390897113,1.3223002675621603E-4,3.8786699141861525,0.016107821092686384,1.7929632026858233,60]
["O43502","DNA repair protein RAD51 homolog 3 [OS=Homo sapiens]",2,1,1,1,376,42.2,6.74,2.89,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","RAD51C","ENSG00000108384","Homologous recombination; Fanconi anemia pathway","Resolution of D-loop Structures through Holliday Junction Intermediates; Factors involved in megakaryocyte development and platelet production; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Meiotic recombination","DNA repair pathways, full network",22.1,23.3,21.1,32.7,29.1,33.7,0.6963350785340314,-0.5221463925345591,0.003247550666285388,2.488444064607047,0.0668629516052955,1.1748144557781681,355]
["O43504","Ragulator complex protein LAMTOR5 [OS=Homo sapiens]",37,2,2,2,91,9.6,4.87,3.67,"cell organization and biogenesis;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","LAMTOR5","ENSG00000134248","mTOR signaling pathway","mTORC1-mediated signalling; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK","",54.6,53.6,58.2,67.9,78,54.8,0.8290981564524167,-0.27038518322152466,0.1708904072588171,0.7672823152282908,0.42225760197927453,0.3744225230051916,2958]
["O43513","Mediator of RNA polymerase II transcription subunit 7 [OS=Homo sapiens]",6,1,2,1,233,27.2,5.78,6.96,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","MED7","ENSG00000155868","","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Generic Transcription Pathway","",51.2,51.2,38.9,58,63,109.3,0.6135475466782458,-0.7047529454589061,0.15286827587241197,0.8156826325933154,0.40438444746705,0.39320555562585374,2763]
["O43521","Bcl-2-like protein 11 [OS=Homo sapiens]",15,2,2,2,198,22.2,8.21,4.69,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;other cell component","cytoskeletal activity;other molecular function","BCL2L11","ENSG00000153094","EGFR tyrosine kinase inhibitor resistance; FoxO signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Apoptosis; Non-alcoholic fatty liver disease; Epstein-Barr virus infection; Pathways in cancer; MicroRNAs in cancer; Colorectal cancer","NRAGE signals death through JNK; Signaling by BRAF and RAF1 fusions; Activation of BIM and translocation to mitochondria ; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; RUNX3 regulates BCL2L11 (BIM) transcription; FLT3 Signaling; FOXO-mediated transcription of cell death genes","Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Photodynamic therapy-induced unfolded protein response; BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Nonalcoholic fatty liver disease; EGFR tyrosine kinase inhibitor resistance; Host-pathogen interaction of human coronaviruses - apoptosis; Unfolded protein response; Galanin receptor pathway; ErbB signaling pathway; DNA damage response (only ATM dependent)",96,104.2,73.4,70.5,91,130.5,0.936986301369863,-0.09390013888148167,0.7729851629143248,0.11182884207944663,0.8448853829431434,0.07320220339537385,6687]
["O43524","Forkhead box protein O3 [OS=Homo sapiens]",11,7,16,7,673,71.2,5.16,48.59,"RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","FOXO3","ENSG00000118689","EGFR tyrosine kinase inhibitor resistance; Chemokine signaling pathway; FoxO signaling pathway; Mitophagy; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Neurotrophin signaling pathway; Prolactin signaling pathway; Alcoholic liver disease; Shigellosis; Chemical carcinogenesis; Endometrial cancer; Non-small cell lung cancer","AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of localization of FOXO transcription factors; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; MAPK6/MAPK4 signaling; Signaling by NODAL; Interleukin-4 and Interleukin-13 signaling; FOXO-mediated transcription of cell cycle genes; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; RUNX3 regulates BCL2L11 (BIM) transcription; FLT3 Signaling; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation","IL-5 signaling pathway; Energy metabolism; Glioblastoma signaling pathways; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Kit receptor signaling pathway; Copper homeostasis; NAD metabolism, sirtuins and aging; Imatinib and chronic myeloid leukemia; Pathways affected in adenoid cystic carcinoma; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Non-small cell lung cancer; Overview of leukocyte-intrinsic Hippo pathway functions; Gastrin signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; DNA damage response (only ATM dependent)",1800.1,1734,1744.3,2468.2,2578.4,2778.4,0.6745559105431309,-0.5679900690297749,8.0208928567885142E-4,3.0957772849336163,0.033121302762862855,1.47989258941145,177]
["O43566","Regulator of G-protein signaling 14 [OS=Homo sapiens]",27,12,22,1,566,61.4,8.19,49.83,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","RGS14","ENSG00000169220","Rap1 signaling pathway","G alpha (i) signalling events","Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells",1425.4,1402.7,1459.4,1507.3,1661.7,2534.2,0.7517709356150933,-0.41163495478511536,0.214448343938511,0.6686773032190018,0.4607298488673066,0.336553650611579,3402]
["O43566-5","Isoform 3 of Regulator of G-protein signaling 14 [OS=Homo sapiens]",36,12,24,1,414,44.8,9.2,56.83,"","","","RGS14","","","","",134.7,138.5,150.5,145.3,142.3,573.5,0.4920450586459179,-1.0231376595901394,0.366521308936424,0.4359007711334054,0.5602058232991056,0.2516523810291884,4782]
["O43567","E3 ubiquitin-protein ligase RNF13 [OS=Homo sapiens]",8,2,5,2,381,42.8,4.98,13.39,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RNF13","ENSG00000082996","","","",906.2,934.2,898.8,954.4,1071.8,408.9,1.124881935033469,0.16977358750434415,0.6461423544577993,0.18967179014010951,0.7516559714677791,0.12398088797207574,6283]
["O43572","A-kinase anchor protein 10, mitochondrial [OS=Homo sapiens]",9,4,5,4,662,73.8,6.39,16.72,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;other cell component","other molecular function","AKAP10","ENSG00000108599","","Factors involved in megakaryocyte development and platelet production","G protein signaling pathways",207.7,204,203,251.1,230,339.8,0.7488122792057497,-0.41732400210815,0.11076745399276619,0.9555878264999469,0.35199970488396876,0.4534577006335668,2300]
["O43583","density-regulated protein [OS=Homo sapiens]",22,5,11,5,198,22.1,5.3,35.13,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","","nucleic acid binding activity","DENR","ENSG00000139726","","","",795.3,840.5,977.2,1045.8,1092.6,855.3,0.872832949193306,-0.19622253087416458,0.2350409613844271,0.6288564451621502,0.47759643779782535,0.3209389210966883,3597]
["O43592","Exportin-T [OS=Homo sapiens]",29,21,53,21,962,109.9,5.39,161.81,"transport","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","XPOT","ENSG00000184575","Nucleocytoplasmic transport","tRNA processing in the nucleus","",4333.4,4440.2,4387.8,4513.4,4113,6574.5,0.8658303126788545,-0.2078437847668437,0.4233917158580568,0.37325764370047576,0.591809151120011,0.2278183236461584,5229]
["O43598-1","2'-deoxynucleoside 5'-phosphate N-hydrolase 1 [OS=Homo sapiens]",68,8,60,8,174,19.1,5.05,166.11,"other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","C6orf108; DNPH1","ENSG00000112667","","Purine catabolism","",5462.2,5522.3,5174.7,5684.6,5691.1,6981.2,0.8802793499991829,-0.18396667010952875,0.17450397875239848,0.7581946665242143,0.4258596262775561,0.3707335313655715,2995]
["O43615","Mitochondrial import inner membrane translocase subunit TIM44 [OS=Homo sapiens]",56,29,144,29,452,51.3,8.32,402.17,"cell organization and biogenesis;transport","other membranes;mitochondrion;nucleus","other molecular function","TIMM44","ENSG00000104980","","Mitochondrial protein import","",18323.3,17995.7,17755.7,17154.6,17212.4,17275.2,1.047102950687616,0.06640329436491418,0.008509554305248754,2.070093185842556,0.10686655054478204,0.9711582086084715,582]
["O43617-1","Trafficking protein particle complex subunit 3 [OS=Homo sapiens]",47,9,26,9,180,20.3,4.96,60.57,"transport","other membranes;cytosol;ER/Golgi;other cell component","","TRAPPC3","ENSCANG00000028241; ENSCATG00000041647; ENSCSAG00000001096; ENSG00000054116; ENSGGOG00000004752; ENSMMUG00000022499; ENSMNEG00000014589; ENSPPAG00000041117; ENSPPYG00000001546; ENSRBIG00000043692; ENSRROG00000034420","","COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs","",4999.8,5054.9,5062.5,5092.8,5009.6,4117.2,1.063124138513038,0.08831006682249098,0.3930886085654969,0.40550954154960994,0.5745020275955243,0.2407084342133047,5001]
["O43633","charged multivesicular body protein 2a [OS=Homo sapiens]",33,9,33,9,222,25.1,5.97,66.06,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle","other molecular function","CHMP2A","ENSG00000130724","Endocytosis; Necroptosis","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Lysosome Vesicle Biogenesis; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","",3355.3,3354.3,3393.1,3656.7,3612.8,3639.6,0.9260800615999487,-0.11079117194152291,1.1875913272167406E-4,3.9253329826452634,0.016377556623824823,1.7857508903620793,53]
["O43639","Cytoplasmic protein NCK2 [OS=Homo sapiens]",22,8,11,7,380,42.9,6.95,32.89,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","NCK2","ENSG00000071051","ErbB signaling pathway; Axon guidance; T cell receptor signaling pathway; Pathogenic Escherichia coli infection","RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; Downstream signal transduction; VEGFA-VEGFR2 Pathway; Ephrin signaling; Activation of RAC1; Regulation of cortical dendrite branching","Pathogenic Escherichia coli infection; Brain-derived neurotrophic factor (BDNF) signaling pathway; EGF/EGFR signaling pathway; Genes controlling nephrogenesis; ErbB signaling pathway",897.3,924.7,919.7,1010.2,1007.6,874.6,0.947897939427465,-0.07719636298788009,0.3320748414663706,0.4787640260162231,0.5428617795297926,0.26531073400028193,4471]
["O43660-1","Pleiotropic regulator 1 [OS=Homo sapiens]",37,13,23,13,514,57.2,9.17,85.7,"RNA metabolism OR transcription;other metabolic processes;other biological processes","other membranes;nucleus;other cell component","","PLRG1","ENSG00000171566","Spliceosome","mRNA Splicing - Major Pathway","",2173.4,2097,2118.9,2478.4,2522.9,2725.3,0.826922579142184,-0.2741758318949145,0.004924030319431781,2.307679281589345,0.08033423572483679,1.095099333703516,448]
["O43663-1","Protein regulator of cytokinesis 1 [OS=Homo sapiens]",25,12,17,12,620,71.6,6.68,47.23,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","PRC1","ENSG00000198901","","RHO GTPases activate CIT","",1146.4,1071.7,1066.4,1730.3,1321.3,1622.7,0.7026720578482339,-0.5090765647691677,0.02077874929584376,1.6823805968298735,0.16725977819749122,0.7766084834669857,908]
["O43670-1","BUB3-interacting and GLEBS motif-containing protein ZNF207 [OS=Homo sapiens]",13,6,33,6,478,50.7,9.1,112.27,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","LOC111151255; Znf207; ZNF207","ENSAMEG00000005671; ENSANAG00000033773; ENSCANG00000036057; ENSCJAG00000014376; ENSECAG00000017464; ENSG00000010244; ENSGGOG00000024003; ENSMFAG00000001904; ENSMLEG00000018149; ENSMMUG00000016875; ENSMNEG00000041308; ENSNLEG00000005954; ENSOCUG00000008195; ENSPCOG00000020744; ENSPPAG00000032098; ENSPTRG00000008989; ENSRROG00000037743; ENSSBOG00000026038; ENSSTOG00000000712","","","",3670.7,3722.7,3690.4,3916.2,4030.8,4956,0.8590095326668217,-0.2192539534481394,0.1395534424413054,0.8552594460630344,0.38856994697276237,0.41053079192103714,2625]
["O43674-1","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [OS=Homo sapiens]",25,6,26,6,189,21.7,9.63,70.78,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB5","ENSG00000136521; ENSGGOG00000005222; ENSPTRG00000015649","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",3138.8,3254.2,3243.7,3228.6,3310.1,1843.9,1.1496075203397513,0.20114140455696317,0.4304400001640049,0.36608737711093503,0.5965274860065818,0.22436954068437753,5274]
["O43676","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [OS=Homo sapiens]",11,1,5,1,98,11.4,9.2,14.66,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity","NDUFB3","ENSG00000119013","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease",587.4,598.6,540.3,759.8,804.6,422.1,0.8690158570349861,-0.20254559258069274,0.5165231715980731,0.2869101909469679,0.6586301223325745,0.1813584107883018,5732]
["O43678","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [OS=Homo sapiens]",29,2,3,2,99,10.9,9.57,10.45,"cell organization and biogenesis;other metabolic processes;transport;developmental processes","other membranes;mitochondrion","transporter activity","NDUFA2","ENSG00000131495","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",166.9,176.4,169.2,198.6,191.7,230.1,0.826079948420374,-0.27564668175592,0.04165096029367252,1.3803749811615096,0.22253426080881025,0.652603116661634,1368]
["O43681","ATPase ASNA1 [OS=Homo sapiens]",50,11,55,11,348,38.8,4.91,159.62,"cell organization and biogenesis;transport","ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","GET3","ENSG00000198356","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",6009,5798.2,5949.7,5886.9,5263,4360.5,1.1448383020425006,0.19514384520866015,0.16956651798012065,0.7706598979047503,0.421551591808402,0.3751492664329346,2940]
["O43683","Mitotic checkpoint serine/threonine-protein kinase BUB1 [OS=Homo sapiens]",14,13,24,13,1085,122.3,6.47,63.69,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","BUB1","ENSG00000169679","Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Cell cycle; ATM signaling in development and disease ; Regulation of sister chromatid separation at the metaphase-anaphase transition",1641.5,1739.9,1669.2,1320.6,1271.7,1747.3,{"$f":"AVERAGE(S386:U386)/AVERAGE(V386:X386)","v":1.1638399852520969},{"$f":"LOG(Y386,2)","v":0.21889271773731725},{"$f":"TTEST(S386:U386,V386:X386,2,2)","v":0.1983158779484373},{"$f":"-LOG10(AA386)","v":0.7026425130799506},{"$f":"AA386*7309/AE386","v":0.4462717832281799},{"$f":"-LOG10(AC386)","v":0.3504005717651154},3248]
["O43684","Mitotic checkpoint protein BUB3 [OS=Homo sapiens]",40,11,57,11,328,37.1,6.84,184.97,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","BUB3","ENSG00000154473","Cell cycle; Human T-cell leukemia virus 1 infection","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A","Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition",4218.7,4209.5,4290.3,4480.1,4289,4940.3,0.9277211256510132,-0.10823690063887953,0.16549301422688453,0.7812203338927817,0.4181086902814722,0.37871080565679166,2893]
["O43707","Alpha-actinin-4 [OS=Homo sapiens]",72,59,636,38,911,104.8,5.44,2080.36,"transport;signal transduction;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function","ACTN4","ENSG00000130402; ENSG00000282844","Focal adhesion; Adherens junction; Tight junction; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Shigellosis; Amoebiasis; Viral carcinogenesis; Systemic lupus erythematosus","Platelet degranulation ; Nephrin family interactions","Arrhythmogenic right ventricular cardiomyopathy; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Striated muscle contraction pathway; Ebola virus pathway in host; Nephrotic syndrome",69423.1,69038.9,68692.4,64818.1,64268.4,78807.3,0.9964433763777466,-5.1402696926153004E-3,0.9612039958379415,0.017184432451198803,0.9754845883892688,0.010779587602492393,7202]
["O43708","maleylacetoacetate isomerase [OS=Homo sapiens]",5,2,4,2,216,24.2,8.54,8.57,"other metabolic processes;other biological processes","cytosol;mitochondrion","other molecular function","GSTZ1","ENSG00000100577","Tyrosine metabolism; Metabolic pathways","Regulation of pyruvate dehydrogenase (PDH) complex; Glutathione conjugation; Tyrosine catabolism","Metapathway biotransformation Phase I and II",609.2,593.3,588.5,585.4,583,866.6,0.8800982800982801,-0.18426345716764828,0.4372512124797599,0.3592689775667494,0.601179291199128,0.2209959879534709,5316]
["O43709-1","Probable 18S rRNA (guanine-N(7))-methyltransferase [OS=Homo sapiens]",16,3,9,3,281,31.9,8.73,35.36,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","BUD23","ENSG00000071462; ENSGGOG00000001453","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","7q11.23 copy number variation syndrome",720.7,755.3,734.9,1116.2,1101.8,1123.9,0.6615697657021455,-0.5960347912552513,6.0146574135136583E-6,5.2207891044268395,7.3268551725618886E-3,2.1350823929265106,6]
["O43719","HIV Tat-specific factor 1 [OS=Homo sapiens]",66,46,151,46,755,85.8,4.4,460.43,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","","HTATSF1","ENSG00000102241","","","",15977.3,15432.6,15800.4,14812.8,15296.4,16307.7,1.017092912279795,0.02445147660209178,0.6027326807180828,0.2198752600490275,0.71842354262369,0.1436194443473921,6132]
["O43739","cytohesin-3 [OS=Homo sapiens]",18,6,17,2,400,46.3,5.47,57.64,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","CYTH3","ENSG00000008256","Phospholipase D signaling pathway; Endocytosis; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection","Intra-Golgi traffic","Insulin signaling",419.2,403.4,444.1,586.6,611.6,1137.7,0.5422749261526606,-0.882903630695976,0.11890394306654026,0.9248037431639332,0.36271657757652037,0.4404325949972339,2396]
["O43741","5'-AMP-activated protein kinase subunit beta-2 [OS=Homo sapiens]",4,1,1,1,272,30.3,6.46,2.61,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","PRKAB2","ENSG00000131791","FoxO signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Apelin signaling pathway; Tight junction; Circadian rhythm; Thermogenesis; Insulin signaling pathway; Adipocytokine signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Insulin resistance; Non-alcoholic fatty liver disease; Alcoholic liver disease; Hypertrophic cardiomyopathy","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Carnitine metabolism; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; AMPK inhibits chREBP transcriptional activation activity; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Lipophagy","AMP-activated protein kinase (AMPK) signaling; Target of rapamycin (TOR) signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Angiopoietin-like protein 8 regulatory pathway; Lipid metabolism pathway; Caloric restriction and aging; Genotoxicity pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; Malignant pleural mesothelioma",68.3,52.8,58.9,65.9,60.9,49.3,1.0221465076660987,0.03160199738582856,0.8549809671007882,0.0680435530789687,0.9030427584594887,0.044291685651753496,6920]
["O43747-1","AP-1 complex subunit gamma-1 [OS=Homo sapiens]",28,21,71,21,822,91.3,6.8,217.4,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","AP1G1","ENSCANG00000031796; ENSCCAG00000037984; ENSCJAG00000015028; ENSG00000166747; ENSGGOG00000004800; ENSMFAG00000037769; ENSMLEG00000040277; ENSMMUG00000010878; ENSMNEG00000034875; ENSPANG00000016832; ENSPPAG00000031149; ENSPTRG00000008327; ENSRBIG00000018408; ENSRROG00000025423; ENSSBOG00000025975","Lysosome; Human immunodeficiency virus 1 infection","MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression","",7519,7716.7,7530.1,7224.4,6492.4,4606,1.2424847730696185,0.3132281713436507,0.13138510891938296,0.8814538545678394,0.3773256428651356,0.42328367935664396,2545]
["O43752","Syntaxin-6 [OS=Homo sapiens]",49,6,22,6,255,29.2,4.93,71.86,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","STX6","ENSG00000135823","SNARE interactions in vesicular transport","Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network","",1397.3,1429.6,1410.6,1251.7,1374.4,1315.7,1.075016489928459,0.10435878981990018,0.05469234517497383,1.2620734539390628,0.254453437863707,0.5943916770950632,1571]
["O43760","Synaptogyrin-2 [OS=Homo sapiens]",42,6,64,6,224,24.8,4.94,159.97,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","SYNGR2","ENSG00000108639","","","",5179.2,5032.9,5152.8,4717.2,4866.4,5040.2,1.0506776624406788,0.07132013254930232,0.07565933864917847,1.1211374592667445,0.29972580281129835,0.5232758678778506,1845]
["O43765","Small glutamine-rich tetratricopeptide repeat-containing protein alpha [OS=Homo sapiens]",39,11,76,11,313,34,4.87,190.79,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","SGTA","ENSG00000104969","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",9434.7,9516.7,9227.3,8752.8,9262,6439.7,1.152290989388456,0.20450508825226751,0.22795586336080495,0.642149232624143,0.47199133294734374,0.3260659761279926,3530]
["O43766-1","Lipoyl synthase, mitochondrial [OS=Homo sapiens]",4,2,2,2,372,41.9,8.59,4.94,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","mitochondrion","other molecular function","LIAS","ENSG00000121897","Lipoic acid metabolism; Metabolic pathways; Biosynthesis of cofactors","Glyoxylate metabolism and glycine degradation","",258.3,231.5,225.4,257.9,268.6,164.8,1.034572544481412,0.04903481087613805,0.828591169759544,0.08165969926019442,0.8851465740678907,0.05298480722526517,6842]
["O43768","alpha-endosulfine [OS=Homo sapiens]",17,2,3,2,121,13.4,7.24,9.83,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","ENSA","ENSG00000143420","","MASTL Facilitates Mitotic Progression","",246,193.9,242.6,254.7,241.2,118.2,1.111382510991695,0.1523554429500102,0.65007657702042,0.18703548179014862,0.7552709746371403,0.12189720509118193,6291]
["O43772","mitochondrial carnitine/acylcarnitine carrier protein [OS=Homo sapiens]",49,14,46,14,301,32.9,9.41,134.56,"transport;developmental processes","other membranes;cytosol;mitochondrion","transporter activity","SLC25A20","ENSG00000178537","Thermogenesis","Carnitine metabolism","Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation; Thermogenesis",7754.9,7623.5,7869.5,7116.8,6572.5,5849.2,1.1898508073803005,0.25078068870447895,0.029752672377297586,1.5264740199660196,0.1962655978390506,0.7071558184744576,1108]
["O43776","Asparagine--tRNA ligase, cytoplasmic [OS=Homo sapiens]",44,27,177,26,548,62.9,6.25,523.97,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","NARS1","ENSG00000134440","Aminoacyl-tRNA biosynthesis","Cytosolic tRNA aminoacylation","Photodynamic therapy-induced unfolded protein response",20524.5,20708,20484.6,21624.7,21700,21522.9,0.951725275877596,-0.07138290825279764,2.6253699625485938E-4,3.580809487925843,0.02041364793219965,1.6900793796415687,94]
["O43791","Speckle-type POZ protein [OS=Homo sapiens]",3,1,1,1,374,42.1,5.8,3.23,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","SPOP","ENSG00000121067","Hedgehog signaling pathway","Hedgehog 'on' state","mRNA processing; Hedgehog signaling pathway",45.6,48.6,45.9,101,83.8,49.2,0.5987179487179487,-0.7400515740399488,0.10958217036653335,0.9602601022506903,0.34990654574442653,0.4560479330412602,2289]
["O43795","Unconventional myosin-Ib [OS=Homo sapiens]",7,7,9,7,1136,131.9,9.38,22.07,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","MYO1B","ENSG00000128641","Pathogenic Escherichia coli infection","","",594.6,603.7,631.1,595,555.3,855.9,0.9118731931013859,-0.13309488058884492,0.5683049943063442,0.24541852732645472,0.6964690146520908,0.15709820022343873,5964]
["O43808","peroxisomal membrane protein PMP34 [OS=Homo sapiens]",8,3,6,3,307,34.5,10.08,14.39,"other metabolic processes;transport","other membranes;cytosol;other cytoplasmic organelle","transporter activity;other molecular function","SLC25A17","ENSG00000100372","Peroxisome","Class I peroxisomal membrane protein import; Alpha-oxidation of phytanate","",770.4,729,722.8,790.2,800.9,428.8,1.100153472944205,0.13770479575990802,0.6132407137783134,0.21236901953473825,0.725623502834012,0.1392886589884591,6177]
["O43809","Cleavage and polyadenylation specificity factor subunit 5 [OS=Homo sapiens]",60,13,65,13,227,26.2,8.82,198.22,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","NUDT21","ENSG00000167005","mRNA surveillance pathway","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs","mRNA processing",9269.8,9176.4,9216,8855,9240.8,9662.8,0.9965272023805233,-5.0189077820444765E-3,0.8977730074318748,0.046833456296379646,0.9311512574598514,0.030979765909674984,7047]
["O43813","LanC-like protein 1 [OS=Homo sapiens]",23,8,19,8,399,45.3,7.75,56.37,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","LANCL1","ENSG00000115365","Glutathione metabolism; Metabolic pathways","","",1627.9,1593.3,1638.3,1518.3,1540.6,1446.6,1.0785706358894684,0.10912066208987778,0.019913909358714944,1.7008434739627751,0.16335663692799948,0.7868632161156768,891]
["O43815","striatin [OS=Homo sapiens]",31,19,52,19,780,86.1,5.27,148.03,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","STRN","ENSG00000115808","","Extra-nuclear estrogen signaling; PIP3 activates AKT signaling; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins","",5321,5228.8,5217.1,5585.3,5696.3,6241.7,0.8997677378119419,-0.15237545650247988,0.04643736031437047,1.3331324752703555,0.23439963158683272,0.6300430752475107,1448]
["O43818","U3 small nucleolar RNA-interacting protein 2 [OS=Homo sapiens]",34,14,42,14,475,51.8,7.85,119.52,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","RRP9","ENSG00000114767","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",4979.7,4909.7,5006.6,5294.4,4605.5,7108.3,0.8758128432168012,-0.1913054887719173,0.3992834129350542,0.39871873092863414,0.5775504581718407,0.23841006728289169,5053]
["O43819","Protein SCO2 homolog, mitochondrial [OS=Homo sapiens]",41,9,41,9,266,29.8,8.85,136.52,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","other membranes;cytoskeleton;mitochondrion","other molecular function","SCO2","ENSG00000284194","Central carbon metabolism in cancer","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","",3018.2,2977,2996.4,2897.6,2781.2,3879.4,0.9407210562658244,-0.08816109818297496,0.6166310256023719,0.2099746276650963,0.7279851665526953,0.13787746979402826,6191]
["O43823","A-kinase anchor protein 8 [OS=Homo sapiens]",30,12,37,12,692,76.1,5.15,125.45,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","mitochondrion;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","AKAP8","ENSG00000105127","","","G protein signaling pathways",3172.4,3143.6,3136.8,3875.2,4080.6,2723.5,0.8851516485162885,-0.17600344893479278,0.3879707559195371,0.4112010089970966,0.5721707536351689,0.24247434481714944,4956]
["O43824","Putative GTP-binding protein 6 [OS=Homo sapiens]",11,5,7,5,516,56.8,9.42,21.19,"","","","","","","","",638.7,623.9,627.1,715.5,642.9,1442.4,0.6747000856898029,-0.5676817498220107,0.2999973539138009,0.5228825758993475,0.525822700181288,0.2791606689891321,4170]
["O43826-1","Glucose-6-phosphate exchanger SLC37A4 [OS=Homo sapiens]",9,3,9,3,429,46.3,8.62,22.03,"other metabolic processes;transport;other biological processes","other membranes;ER/Golgi","transporter activity","SLC37A4","ENSG00000281500","Carbohydrate digestion and absorption","Gluconeogenesis; Glycogen storage disease type Ib (SLC37A4)","",787.9,822.5,831,777.8,803.8,690.5,1.0745125654680692,0.10368235389875667,0.19907133611845237,0.7009912686605112,0.44687112889734903,0.34981770299370185,3256]
["O43829","Zinc finger and BTB domain-containing protein 14 [OS=Homo sapiens]",20,5,6,5,449,50.9,6.04,14.2,"developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB14","ENSG00000198081","","","",336.7,363.9,338.6,407,461.2,656,0.6818002886760266,-0.5525788845685178,0.10087328764097649,0.9962238245066705,0.33804807857308444,0.47102152820139775,2181]
["O43837-1","isocitrate dehydrogenase [NAD] subunit beta, mitochondrial [OS=Homo sapiens]",46,15,78,14,385,42.2,8.46,228.86,"other metabolic processes","mitochondrion","other molecular function","IDH3B","ENSG00000101365","Citrate cycle (TCA cycle); Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids","Citric acid cycle (TCA cycle)","TCA cycle (aka Krebs or citric acid cycle)",11824,11955.6,11955.5,10834.9,9659,8646,1.2263288480742895,0.29434589898781793,0.025639471750705557,1.5910909268176878,0.18264999905059154,0.7383803257095124,1026]
["O43847-1","Nardilysin [OS=Homo sapiens]",26,26,63,26,1150,131.5,5,183.22,"","","","","","","","",7313.7,7356,7469.2,7337.2,6665.7,5638.7,1.1271434099055069,0.17267108569369832,0.16863117434476524,0.7730621355571351,0.42080070101942274,0.37592354535476075,2929]
["O43852","Calumenin [OS=Homo sapiens]",71,22,218,6,315,37.1,4.64,726.76,"","non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","CALU","ENSG00000128595","","Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","NOTCH1 regulation of endothelial cell calcification; VEGFA-VEGFR2 signaling pathway",20489.4,20611.6,26238.8,26480.9,23816.2,18907.5,0.9730538143418213,-0.03940850001748679,0.8417374484854259,0.07482335084621225,0.8937040980505487,0.04880625061776195,6884]
["O43852-4","Isoform 4 of Calumenin [OS=Homo sapiens]",59,17,159,1,323,38.1,4.58,498.58,"","","","CALU","","","","",336.5,321.9,419.3,353.2,365.9,218.7,1.1491789294092558,0.2006034459160221,0.45192471894184666,0.344933903398954,0.61191511129047,0.21330882173547888,5398]
["O43861-1","Probable phospholipid-transporting ATPase IIB [OS=Homo sapiens]",9,8,12,8,1147,129.2,7.61,36.53,"cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ATP9B","ENSG00000166377","","Ion transport by P-type ATPases","",1303.8,1359.1,1361.7,1227,1412.9,1309.5,1.019040866967134,0.02721190958869843,0.6828024817512698,0.16570490904394256,0.7785652635132654,0.10870497667878701,6410]
["O43865","S-adenosylhomocysteine hydrolase-like protein 1 [OS=Homo sapiens]",29,14,43,7,530,58.9,6.89,134.9,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","nucleic acid binding activity;other molecular function","AHCYL1","ENSG00000168710","Cysteine and methionine metabolism; Metabolic pathways","Role of phospholipids in phagocytosis; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Ion homeostasis; Regulation of insulin secretion; VEGFR2 mediated cell proliferation; PLC beta mediated events; DAG and IP3 signaling; CLEC7A (Dectin-1) induces NFAT activation","Trans-sulfuration and one-carbon metabolism; One-carbon metabolism and related pathways",3704.3,3534.2,3619.4,3186.4,2955.9,2999.9,1.1876681761501606,0.24813181636467907,2.6595705908166256E-3,2.5751884780656136,0.05855060677192385,1.232468599885677,332]
["O43896","Kinesin-like protein KIF1C [OS=Homo sapiens]",9,10,10,4,1103,122.9,6.9,26.12,"transport;other biological processes","cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","KIF1C","ENSG00000129250","","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",264.7,282.4,255.9,279.9,332.3,632,0.6453946310882493,-0.6317465185105628,0.2520503716000365,0.5985126579412586,0.49323592129174487,0.3069453022087032,3735]
["O43903","Growth arrest-specific protein 2 [OS=Homo sapiens]",38,9,25,9,313,34.9,8.47,91.92,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton","cytoskeletal activity;other molecular function","GAS2","ENSG00000148935","","Caspase-mediated cleavage of cytoskeletal proteins","",3013.8,2972.4,2988,2971.8,3130.2,2280.9,1.0705364492001577,0.0983339168678444,0.4922047342323216,0.30785421338598895,0.639901174404845,0.19388709277343788,5622]
["O43913","Origin recognition complex subunit 5 [OS=Homo sapiens]",19,9,17,9,435,50.3,7.74,48.42,"DNA metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ORC5","ENSG00000164815","Cell cycle","CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication","Cell cycle; G1 to S cell cycle control; DNA replication",1991,2033.4,2013.4,1984.5,2112.6,1643.4,1.0517899137705775,0.07284656714997505,0.5196641661772158,0.2842772292384216,0.6609057578892066,0.17986046448814622,5747]
["O43920","NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [OS=Homo sapiens]",11,1,2,1,106,12.5,9.14,3.58,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity","NDUFS5","ENSG00000168653","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",51.6,66,56.9,60.2,62.7,76.1,0.8768844221105528,-0.1895413943339965,0.2763608065624534,0.558523548492444,0.5107259507370345,0.29181207444216645,3955]
["O43924","Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [OS=Homo sapiens]",25,3,5,3,150,17.4,5.67,16.56,"other biological processes","other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","PDE6D","ENSG00000156973","Purine metabolism; Metabolic pathways","ARL13B-mediated ciliary trafficking of INPP5E; RAS processing","Phosphodiesterases in neuronal function; Joubert syndrome; Ciliopathies",752.3,692.5,734.1,564.2,523.5,529.5,1.3473287162997774,0.4301018771695541,1.0051791116423457E-3,2.9977565449428947,0.036013990818597574,1.4435287504848204,204]
["O43929","origin recognition complex subunit 4 [OS=Homo sapiens]",15,5,11,5,436,50.3,8,26.58,"DNA metabolism;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ORC4","ENSG00000115947","Cell cycle","CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication","Cell cycle; G1 to S cell cycle control; DNA replication",856.4,813.8,872.9,906,876.8,877.7,0.9558729562112384,-0.06510921059723127,0.12266943196616531,0.9112636457680747,0.3670040434878028,0.4353291508575385,2443]
["O43933","Peroxisome biogenesis factor 1 [OS=Homo sapiens]",8,11,16,11,1283,142.8,6.33,44.12,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","PEX1","ENSG00000127980","Peroxisome","Peroxisomal protein import","",1217,1303.3,1298.5,1321.8,1363.9,1689.4,0.8728486206029576,-0.1961966280229459,0.1956163357421295,0.7085948804971504,0.4430616045674696,0.3535358840170824,3227]
["O43934","UNC93-like protein MFSD11 [OS=Homo sapiens]",4,3,3,3,449,49.2,5.68,7.53,"","other membranes","","MFSD11","ENSG00000092931","","","",425.8,396.4,446.4,381,320.4,537,1.0243863049095605,0.03475987068845935,0.8863755236979859,0.052382245022761544,0.9231289117567083,0.03473764701817595,7018]
["O60216","Double-strand-break repair protein rad21 homolog [OS=Homo sapiens]",52,26,97,26,631,71.6,4.65,350.07,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","RAD21","ENSG00000164754","Cell cycle","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin","Cell cycle; Prion disease pathway; Regulation of sister chromatid separation at the metaphase-anaphase transition; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome",7307.4,7444.5,7528.6,8137,8262,7143.3,0.9464028578346211,-0.07947366472444281,0.30724491408561844,0.5125152973848202,0.5312640352618371,0.27468958332986604,4227]
["O60231","Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [OS=Homo sapiens]",23,21,45,21,1041,119.2,6.8,125.94,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","DHX16","ENSG00000204560; ENSG00000206486; ENSG00000226171; ENSG00000231377; ENSG00000233049; ENSG00000233418; ENSG00000233561","Spliceosome","mRNA Splicing - Major Pathway","mRNA processing",5722.1,5678.4,5703.3,6783.3,6634.3,6338.5,0.8657477943521242,-0.20798128798470358,2.5362829016636087E-3,2.5958023060824935,0.05811188629548374,1.2357350272557017,319]
["O60232","Sjoegren syndrome/scleroderma autoantigen 1 [OS=Homo sapiens]",27,3,5,3,199,21.5,5.24,24.01,"cell cycle OR cell proliferation;other biological processes","","","ZNRD2","ENSG00000173465","","","",394.9,382.5,346.1,469.7,479.7,702.2,0.6802494550738678,-0.5558641991089075,0.08500953608449369,1.0705323538553797,0.315558506471084,0.5009201081095249,1969]
["O60234","glia maturation factor gamma [OS=Homo sapiens]",45,6,29,5,142,16.8,5.26,95.43,"protein metabolism;other metabolic processes;signal transduction;other biological processes","non-structural extracellular;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function","GMFG","ENSG00000130755","","Neutrophil degranulation","",2496.4,2712.1,2588.6,2702.7,2764.4,2701.4,0.954532655934382,-0.06713353974250232,0.13328610249659786,0.8752151313340022,0.3800968096557291,0.42010577563427326,2563]
["O60237","Protein phosphatase 1 regulatory subunit 12b [OS=Homo sapiens]",13,11,12,10,982,110.3,5.67,29.37,"signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP1R12B","ENSG00000077157","Vascular smooth muscle contraction; Focal adhesion; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Proteoglycans in cancer","RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs","Focal adhesion",635.2,614.2,646.9,706.3,721.5,854.8,0.8307631648120565,-0.26749084490736386,0.05549820574850446,1.2557210573479507,0.2557606467943374,0.5921662784455627,1586]
["O60244","Mediator of RNA polymerase II transcription subunit 14 [OS=Homo sapiens]",6,7,13,6,1454,160.5,8.73,34.12,"other biological processes","nucleus","other molecular function","MED14","ENSG00000180182","Thyroid hormone signaling pathway","Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","Vitamin D in inflammatory diseases",783.8,803.3,776.9,763.9,785.9,1622.8,0.7451301771417764,-0.42443560285523396,0.39453960744065614,0.40390939187286257,0.574783733462977,0.24049553101664115,5017]
["O60256-1","Phosphoribosyl pyrophosphate synthase-associated protein 2 [OS=Homo sapiens]",34,10,27,9,369,40.9,7.44,112.72,"other metabolic processes;other biological processes","other cell component","enzyme regulator activity;other molecular function","PRPSAP2","ENSG00000141127","","","",2713.4,2744.9,2724.4,2837.7,2664.5,2649.7,1.003778260282879,5.440605820823694E-3,0.874617910528091,0.058181633366792475,0.9146633721633736,0.03873871195664394,6989]
["O60264","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 [OS=Homo sapiens]",39,40,133,40,1052,121.8,8.09,366.57,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMARCA5","ENSG00000153147","","Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; NoRC negatively regulates rRNA expression","",13837.3,13898.2,13977.5,15770,16147.3,21682.8,0.7782261600258209,-0.36173861765397164,0.10688877961621787,0.9710678813816375,0.3450751281868094,0.4620863420138982,2264]
["O60266","Adenylate cyclase type 3 [OS=Homo sapiens]",4,4,8,4,1144,128.9,6.58,20.91,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","ADCY3","ENSG00000138031","Purine metabolism; Metabolic pathways; Endocrine resistance; Rap1 signaling pathway; Calcium signaling pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Phospholipase D signaling pathway; Oocyte meiosis; Longevity regulating pathway; Longevity regulating pathway; Adrenergic signaling in cardiomyocytes; Vascular smooth muscle contraction; Apelin signaling pathway; Gap junction; Platelet activation; Circadian entrainment; Thermogenesis; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; GABAergic synapse; Olfactory transduction; Inflammatory mediator regulation of TRP channels; Insulin secretion; GnRH signaling pathway; Ovarian steroidogenesis; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Melanogenesis; Thyroid hormone synthesis; Oxytocin signaling pathway; Regulation of lipolysis in adipocytes; Aldosterone synthesis and secretion; Relaxin signaling pathway; Cortisol synthesis and secretion; Parathyroid hormone synthesis, secretion and action; Cushing syndrome; Growth hormone synthesis, secretion and action; Vasopressin-regulated water reabsorption; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Bile secretion; Morphine addiction; Vibrio cholerae infection; Human cytomegalovirus infection; Human T-cell leukemia virus 1 infection; Pathways in cancer; Chemical carcinogenesis; Dilated cardiomyopathy","FCGR3A-mediated IL10 synthesis; Olfactory Signaling Pathway; G alpha (i) signalling events; G alpha (z) signalling events; Adenylate cyclase inhibitory pathway; ADORA2B mediated anti-inflammatory cytokines production; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Adenylate cyclase activating pathway; Hedgehog 'off' state","Thyroid stimulating hormone (TSH) signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; Phosphodiesterases in neuronal function; Thermogenesis; Envelope proteins and their potential roles in EDMD physiopathology; Neuroinflammation and glutamatergic signaling; Calcium regulation in cardiac cells",261.3,284.3,278.9,265.4,307.7,350.7,0.8925092011257847,-0.16406105252420752,0.2654018931818869,0.5760959835231498,0.5025446728669459,0.2988253263109319,3860]
["O60268-1","Uncharacterized protein KIAA0513 [OS=Homo sapiens]",9,3,3,3,411,46.6,5.06,9.16,"","other cell component","","KIAA0513","ENSG00000135709","","","",348.4,310.6,329,319.6,341.4,249,1.0857142857142856,0.11864449649861893,0.43424826838375685,0.3622619046779359,0.5990790097427102,0.22251589675517516,5298]
["O60271","C-jun-amino-terminal kinase-interacting protein 4 [OS=Homo sapiens]",33,37,102,2,1321,146.1,5.15,305,"transport;other biological processes","other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","SPAG9","ENSG00000008294","","Myogenesis","",11076.3,10794.1,10876.6,10545.3,10468.9,9689.2,1.0665594038445254,0.09296432127643378,0.07588394059083181,1.1198501246413386,0.29980309285318363,0.5231638911603794,1850]
["O60271-2","Isoform 2 of C-Jun-amino-terminal kinase-interacting protein 4 [OS=Homo sapiens]",32,36,103,1,1311,145,5.19,309.2,"","","","SPAG9","","","","",389.7,375,407.1,387.6,387.5,124.8,1.3021446827425274,0.3808897568587213,0.3616025221374824,0.4417685490302716,0.557938111526886,0.2534139718742553,4737]
["O60281-1","zinc finger protein 292 [OS=Homo sapiens]",2,5,5,5,2723,304.6,7.39,7.84,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF292","ENSG00000188994","","","",87.8,77.7,88.3,107.8,100.7,461,0.37908887229275584,-1.3993919863705668,0.30891047298704194,0.5101673675697731,0.5327575854323476,0.27347035806057596,4238]
["O60285","NUAK family SNF1-like kinase 1 [OS=Homo sapiens]",2,1,1,1,661,74.3,8.82,2.03,"cell adhesion;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","NUAK1","ENSG00000074590","","Regulation of TP53 Activity through Phosphorylation","",78.7,62,53.8,82.8,80.8,156,0.6085732165206507,-0.7164972530544229,0.1813667652102272,0.7414422928447469,0.43011346103879,0.36641696534317447,3082]
["O60287","nucleolar pre-ribosomal-associated protein 1 [OS=Homo sapiens]",8,14,26,14,2271,254.2,6.47,81.68,"RNA metabolism OR transcription;other metabolic processes","nucleus","","URB1","ENSG00000142207","","","",2886.4,2762.5,2786.8,3446.5,3317.7,10983.1,0.4753230068799198,-1.0730198613340778,0.2878521077685815,0.540830586118826,0.5193559752358831,0.2845348674184412,4051]
["O60291-1","E3 ubiquitin-protein ligase MGRN1 [OS=Homo sapiens]",6,2,2,2,552,60.7,5.15,7.27,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MGRN1","ENSG00000102858","Ubiquitin mediated proteolysis; Hedgehog signaling pathway","Antigen processing: Ubiquitination & Proteasome degradation","",145.2,178.3,171.7,130,115.8,163.8,1.208984375,0.27379559921426466,0.17762069689485002,0.7505064303168809,0.42761188195140276,0.3689502356563507,3036]
["O60292","Signal-induced proliferation-associated 1-like protein 3 [OS=Homo sapiens]",1,1,1,1,1781,194.5,8.32,2.87,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","enzyme regulator activity","SIPA1L3","ENSG00000105738","Rap1 signaling pathway","","",29.1,25.4,33.1,21.3,21.1,16.5,1.4872665534804752,0.5726632357707125,0.02452715100576875,1.6103528951010477,0.1789111244522593,0.7473626547483017,1002]
["O60293","Zinc finger C3H1 domain-containing protein [OS=Homo sapiens]",8,11,13,11,1989,226.2,8.13,35.99,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","other molecular function","ZFC3H1","ENSG00000133858","","","",627,614.5,685.5,830.6,884.6,868.4,0.7458584920266296,-0.4230261537053064,1.2783157802020075E-3,2.8933618498873983,0.039758340585091374,1.4005717502751616,235]
["O60294","tRNA wybutosine-synthesizing protein 4 [OS=Homo sapiens]",5,3,3,3,686,75.6,6.73,3.98,"RNA metabolism OR transcription;other metabolic processes","other cell component","other molecular function","LCMT2","ENSG00000168806","","Synthesis of wybutosine at G37 of tRNA(Phe)","",358.8,331.6,354.7,354.7,347.9,191.8,1.1684928443649378,0.22464889934895582,0.40388894373471257,0.3937380352695412,0.5797376845555802,0.23676846836718604,5092]
["O60306","Intron-binding protein aquarius [OS=Homo sapiens]",14,20,39,19,1485,171.2,6.37,107.07,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","AQR","ENSG00000021776","Spliceosome","mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER","",3627.6,3693.6,3762,4478,4610.9,4476.3,0.8170318167074573,-0.2915358342492011,1.5110558071766697E-4,3.8207194957527615,0.016733798325233754,1.7764054694106572,66]
["O60307","Microtubule-associated serine/threonine-protein kinase 3 [OS=Homo sapiens]",3,4,6,2,1309,143,8.06,12.05,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction","","kinase activity;other molecular function","MAST3","ENSG00000099308","","","",144.8,134.7,155.7,205.7,198.1,274.2,0.6418879056047198,-0.6396067167733669,0.03155095021075392,1.500987556702799,0.20035264560417065,0.6982049184486179,1151]
["O60308","Centrosomal protein of 104 kDa [OS=Homo sapiens]",2,2,3,2,925,104.4,7.62,7.45,"","cytoskeleton;other cell component","other molecular function","CEP104","ENSG00000116198","","","Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies",280.4,304,315.3,293,235.7,337.8,1.038315060588575,0.054244273542364684,0.7413925972728126,0.12995175466957762,0.8227814293147567,0.08471551916149359,6586]
["O60313-2","Isoform 2 of Dynamin-like 120 kDa protein, mitochondrial [OS=Homo sapiens]",41,39,101,39,997,115.8,7.87,303.65,"","","","OPA1","","","","",12868.9,12579.8,12868.9,12934.5,12496.6,10329.4,{"$f":"AVERAGE(S450:U450)/AVERAGE(V450:X450)","v":1.0715062708854741},{"$f":"LOG(Y450,2)","v":0.09964029327055214},{"$f":"TTEST(S450:U450,V450:X450,2,2)","v":0.35261546663753485},{"$f":"-LOG10(AA450)","v":0.4526986423259238},{"$f":"AA450*7309/AE450","v":0.5549669348952934},{"$f":"-LOG10(AC450)","v":0.255732891508487},4644]
["O60318","Germinal-center associated nuclear protein [OS=Homo sapiens]",12,13,21,13,1980,218.3,6.39,81.22,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","MCM3AP","ENSG00000160294","","","",1244.8,1233.7,1231.7,1281.1,1266.5,1720,0.8693879463867278,-0.20192800135169692,0.2800169206728653,0.5528157246119798,0.5141029071082573,0.2889499403121048,3981]
["O60331","Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [OS=Homo sapiens]",9,6,10,5,668,73.2,5.29,22.5,"cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","PIP5K1C","ENSG00000186111","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Phospholipase D signaling pathway; Endocytosis; Focal adhesion; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Yersinia infection; Choline metabolism in cancer","Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion","B cell receptor signaling pathway; Focal adhesion; Regulation of actin cytoskeleton",1000.9,991.7,941.6,882.3,877.3,1325.8,0.9509950087508914,-0.07249032569346206,0.7534601955848181,0.12293968600957829,0.8313768975738882,0.08020204790242907,6624]
["O60333","Kinesin-like protein KIF1B [OS=Homo sapiens]",15,21,28,9,1816,204.3,5.6,85.55,"cell-cell signaling;transport;other biological processes","other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","KIF1B","ENSG00000054523","","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","Intracellular trafficking proteins involved in CMT neuropathy",2164.4,2140.9,2095,2461.7,2460.7,3108.3,0.7969790927316424,-0.32738621660387046,0.06617192293285537,1.1793262447278128,0.27811994520772854,0.5557678648465524,1739]
["O60333-3","Isoform 3 of Kinesin-like protein KIF1B [OS=Homo sapiens]",13,13,18,1,1153,130.3,8.43,47.74,"","","","KIF1B","","","","",38.6,41.3,32.2,47,43.7,28.9,0.9372909698996655,-0.09343111139267829,0.706746602389064,0.1507362706590696,0.7963019757764249,0.09892220670532333,6487]
["O60337","E3 ubiquitin-protein ligase MARCH6 [OS=Homo sapiens]",2,2,2,2,910,102.5,6.28,5.33,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","other molecular function","MARCHF6","ENSG00000145495","Protein processing in endoplasmic reticulum","ER Quality Control Compartment (ERQC)","",178.8,178.2,184,282.2,288.9,535.9,0.4887082204155375,-1.032954722954737,0.08671133719974422,1.061924116348495,0.3179995803276119,0.49757345316500956,1993]
["O60341","Lysine-specific histone demethylase 1A [OS=Homo sapiens]",20,13,20,13,852,92.8,6.52,66.77,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KDM1A","ENSG00000004487","Thermogenesis","Estrogen-dependent gene expression; Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; Factors involved in megakaryocyte development and platelet production; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3","Androgen receptor signaling pathway; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; Thermogenesis; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects",1766.5,1753.1,1827.3,2261.8,2179,2059,0.8226253115480476,-0.281692631749478,0.003684462312265248,2.433625881442438,0.07049668858729502,1.1518312824701737,382]
["O60343-1","TBC1 domain family member 4 [OS=Homo sapiens]",1,1,1,1,1298,146.5,7.01,0,"transport;other biological processes","cytosol;other cell component","enzyme regulator activity","TBC1D4","ENSG00000136111","Thyroid hormone signaling pathway; Insulin resistance; Diabetic cardiomyopathy","Translocation of SLC2A4 (GLUT4) to the plasma membrane","Ciliary landscape; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling",27.7,25.3,33.2,23.3,23.9,18.5,1.3120243531202433,0.39179449876676836,0.07771027955370359,1.1095215287130697,0.3038975030808023,0.5172728682079287,1869]
["O60344-1","Endothelin-converting enzyme 2 [OS=Homo sapiens]",5,4,10,4,883,99.7,5.1,26.93,"protein metabolism;other metabolic processes;developmental processes","plasma membrane;other membranes;ER/Golgi","other molecular function","EEF1AKMT4-ECE2","ENSG00000284917","","","",1162.2,1122.6,1108.2,1393.1,1286.6,2842.5,0.614429031907573,-0.702681709558194,0.23037475241345212,0.6375651185141799,0.4732459430550651,0.3249131003781131,3558]
["O60353-1","Frizzled-6 [OS=Homo sapiens]",6,3,3,3,706,79.2,7.96,6.58,"cell-cell signaling;cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","FZD6","ENSG00000164930","mTOR signaling pathway; Wnt signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Proteoglycans in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer","Class B/2 (Secretin family receptors); Ca2+ pathway; PCP/CE pathway; Regulation of FZD by ubiquitination; Signaling by RNF43 mutants","Alzheimer's disease and miRNA effects; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Osteoblast differentiation and related diseases; Malignant pleural mesothelioma; Alzheimer's disease",99.1,89.3,97,115.1,126.5,246.4,0.5848360655737704,-0.7738958129744854,0.18396589211549574,0.7352626891596042,0.43207156345506376,0.36444431559328266,3112]
["O60361","putative nucleoside diphosphate kinase [OS=Homo sapiens]",66,8,139,1,137,15.5,8.57,432.69,"other metabolic processes;other biological processes","","kinase activity;other molecular function","NME2P1","","","Interconversion of nucleotide di- and triphosphates","",851.1,855.5,812.3,692.4,652.8,165.6,1.6672623775483189,0.7374811595141855,0.11916262941070357,0.9238599223254039,0.36274871235436584,0.44039412049845833,2401]
["O60381-1","HMG box-containing protein 1 [OS=Homo sapiens]",5,2,2,2,514,57.6,6.19,7.78,"cell-cell signaling;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HBP1","ENSG00000105856; ENSG00000283847; ENSPPAG00000042116; ENSPTRG00000019575","","","",186.4,197.4,202.5,154.4,152.8,222,1.107898715041572,0.14782599511779612,0.45975134845247534,0.33747698830062917,0.6183884074050685,0.20873866049852818,5434]
["O60427","Fatty acid desaturase 1 [OS=Homo sapiens]",2,1,1,1,444,51.9,8.87,2.12,"cell-cell signaling;other metabolic processes;stress response;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","FADS1","ENSG00000149485","Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism","PPARA activates gene expression; alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Linoleic acid metabolism affected by coronavirus infection",226.9,233.2,223.4,367,389,419.4,0.5815041687936022,-0.7821385604953207,4.4729647629957657E-4,3.3494045230875207,0.023690506849808734,1.6254256476047844,138]
["O60447","Ecotropic viral integration site 5 protein homolog [OS=Homo sapiens]",3,2,2,2,810,92.9,6.1,6.74,"cell cycle OR cell proliferation;transport;other biological processes","cytosol;cytoskeleton;nucleus","enzyme regulator activity;other molecular function","EVI5","ENSG00000067208","","","",73.5,81.4,93.5,96.1,89.2,93.6,0.8906418070993188,-0.16708276080783055,0.17395647365472922,0.759559404684644,0.42551802742383393,0.37108203594403216,2988]
["O60449","Lymphocyte antigen 75 [OS=Homo sapiens]",7,11,15,11,1722,198.2,6.67,42.58,"stress response;transport;other biological processes","plasma membrane;other membranes","other molecular function","LY75","ENSG00000054219","","","",1452.8,1513.9,1546.5,1687.8,1741.2,1922.4,0.8433680905931158,-0.24576565758849425,0.021381770556369466,1.6699563350943398,0.16858614994229174,0.7731781073548639,927]
["O60476","mannosyl-oligosaccharide 1,2-alpha-mannosidase IB [OS=Homo sapiens]",7,4,10,4,641,73,7.61,26.26,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","MAN1A2","ENSG00000198162","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum","Intra-Golgi traffic; Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2","",760.5,804.9,762.1,758.6,743.5,1118.5,0.8881553842631459,-0.17111599433102667,0.4728882456792941,0.3252414808673494,0.6280828979956316,0.20198303179453297,5503]
["O60486","Plexin-C1 [OS=Homo sapiens]",24,30,84,29,1568,175.6,7.61,247.2,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","PLXNC1","ENSG00000136040","Axon guidance","Other semaphorin interactions","",8178,8365.4,8399.5,7173.7,7596.6,6837.2,1.1543630683790351,0.2070970494335008,8.466967332232591E-3,2.07227211584645,0.10706758517523876,0.9703419923830061,578]
["O60488-1","Long-chain-fatty-acid--CoA ligase 4 [OS=Homo sapiens]",42,23,70,20,711,79.1,8.38,174.26,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ACSL4","ENSG00000068366","Fatty acid biosynthesis; Fatty acid degradation; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; Peroxisome; Ferroptosis; Thermogenesis; Adipocytokine signaling pathway","Synthesis of very long-chain fatty acyl-CoAs; Intracellular metabolism of fatty acids regulates insulin secretion","Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters",8588.6,8712.3,8704.3,8245.1,8046.9,7127.4,1.1104127347412827,0.15109601863646974,0.06773095143906892,1.16921282367261,0.28143577263681335,0.5506207012460984,1759]
["O60493-1","sorting nexin-3 [OS=Homo sapiens]",15,2,3,2,162,18.8,8.66,9.39,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","LOC111158258; Snx3; SNX3; Snx3_1","ENSAMEG00000008145; ENSANAG00000028701; ENSBIXG00000016466; ENSBIXG00005007963; ENSBMUG00000010256; ENSBTAG00000018801; ENSCANG00000036155; ENSCATG00000029122; ENSCCAG00000022069; ENSCGRG00015001325; ENSCHIG00000003391; ENSCJAG00000005955; ENSCSAG00000015156; ENSDLEG00000017815; ENSFCAG00000024997; ENSG00000112335; ENSLCNG00005012116; ENSMFAG00000039300; ENSMMNG00015010894; ENSMMUG00000020366; ENSMNEG00000027766; ENSMPUG00000009812; ENSMUSG00000019804; ENSNVIG00000004406; ENSOARG00000010805; ENSPANG00000017995; ENSPCOG00000020531; ENSPCTG00005013214; ENSPPAG00000032382; ENSPPYG00000016894; ENSPTRG00000018473; ENSPTRG00000046352; ENSRFEG00010011106; ENSRROG00000037899; ENSSBOG00000028606; ENSSSCG00000004385; ENSSSCG00070023370; ENSSSUG00005019212; ENSSTOG00000007274; ENSTSYG00000035289; ENSTTRG00000008868; ENSUAMG00000027552","Endocytosis","Ub-specific processing proteases; WNT ligand biogenesis and trafficking; Ub-specific processing proteases; WNT ligand biogenesis and trafficking; WNT ligand biogenesis and trafficking; Ub-specific processing proteases; WNT ligand biogenesis and trafficking","",361,383.4,333.7,470.7,471.2,662.4,0.6720064825780714,-0.5734529447134961,0.05515113250031485,1.2584455651170339,0.255611685126697,0.5924192965619639,1577]
["O60496","Docking protein 2 [OS=Homo sapiens]",43,11,20,11,412,45.4,6.02,62.11,"signal transduction","cytosol","signal transduction activity or receptor binding","DOK2","ENSG00000147443","","RET signaling; Tie2 Signaling","RAC1/PAK1/p38/MMP2 pathway; IL-4 signaling pathway; EGF/EGFR signaling pathway",1662.8,1629.4,1582.1,1788.8,1798.2,2269.3,0.8323173334699382,-0.264794412509222,0.11075764028319976,0.9556263055709381,0.3521216149760361,0.45330731495624416,2299]
["O60499","Syntaxin-10 [OS=Homo sapiens]",19,2,3,2,249,28.1,4.89,9.32,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","STX10","ENSG00000104915","Salmonella infection","Retrograde transport at the Trans-Golgi-Network","",25.9,20.8,26.3,21.3,24.2,23.3,1.0610465116279069,0.08548789906528148,0.5159222991563555,0.2874157006762865,0.6585532805682505,0.1814090824778934,5726]
["O60502","protein O-GlcNAcase [OS=Homo sapiens]",33,27,59,27,916,102.8,4.91,160.99,"protein metabolism;other metabolic processes","cytosol;nucleus","other molecular function","OGA","ENSG00000198408","Insulin resistance","","",6510.2,6333.3,6281.8,8554.2,8713.5,6651.8,0.7995693889922447,-0.3227048544136739,0.07436291419548727,1.1286435990746964,0.2976552792195052,0.5262864103890035,1826]
["O60506","Heterogeneous nuclear ribonucleoprotein Q [OS=Homo sapiens]",58,32,270,2,623,69.6,8.59,831.37,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity","SYNCRIP","ENSG00000135316","","","",15475,15459.9,15535.4,18221.6,17923,15128.9,0.9063219791900299,-0.1419044229173385,0.17945665345200376,0.7460404353306063,0.4300487475674411,0.36648231279341925,3050]
["O60506-3","Isoform 3 of Heterogeneous nuclear ribonucleoprotein Q [OS=Homo sapiens]",56,29,255,1,562,62.6,7.56,769.42,"","","","SYNCRIP","","","","",427.5,430.9,459.7,565.7,581.9,1295,0.5396299025628428,-0.8899578001893343,0.19434521807478847,0.7114261408535625,0.4416881837402453,0.35488421904600315,3216]
["O60508","pre-mRNA-processing factor 17 [OS=Homo sapiens]",21,10,17,10,579,65.5,7.06,44.75,"RNA metabolism OR transcription;other metabolic processes","nucleus","","CDC40","ENSG00000168438","Spliceosome","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway","mRNA processing",1449.4,1471.1,1443.1,1884.7,2035.2,1401.4,0.8200251818164735,-0.2862598813469769,0.17061735720712845,0.7679767893711337,0.42201091838473836,0.37467631270443486,2955]
["O60512","beta-1,4-galactosyltransferase 3 [OS=Homo sapiens]",22,6,13,6,393,43.9,9.25,41.19,"protein metabolism;other metabolic processes","other membranes;cytosol;ER/Golgi","other molecular function","B4GALT3","ENSG00000158850","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Other types of O-glycan biosynthesis; Mannose type O-glycan biosynthesis; Glycosaminoglycan biosynthesis; Glycosphingolipid biosynthesis; Metabolic pathways","N-Glycan antennae elongation; Keratan sulfate biosynthesis","",429.1,456.9,484.2,592,681.3,877.6,0.6370356594913757,-0.6505539620738469,0.03871789235683188,1.4120882919295246,0.21552861784926444,0.666495056135031,1313]
["O60518","ran-binding protein 6 [OS=Homo sapiens]",7,6,30,3,1105,124.6,5.01,74.1,"transport","nucleus;other cell component","other molecular function","RANBP6","ENSG00000137040","","","",194.1,203.1,200.2,196.5,195.8,258,0.9186529294171921,-0.12240818612946643,0.44406980029015747,0.352548760745042,0.6065606747001983,0.21712574983532382,5351]
["O60524","nuclear export mediator factor NEMF [OS=Homo sapiens]",16,16,29,16,1076,122.9,6.35,83.71,"protein metabolism;other metabolic processes;transport","nucleus;other cell component","translation activity;nucleic acid binding activity","NEMF","ENSG00000165525","","","",3458.9,3492.5,3491.3,3779.2,3725.1,3271.4,0.9690971352209139,-0.04528681678246146,0.529388744604844,0.27622529652158284,0.6688508788793094,0.17467069792537823,5785]
["O60547-1","GDP-mannose 4,6 dehydratase [OS=Homo sapiens]",32,11,32,11,372,41.9,7.31,83.54,"other metabolic processes;signal transduction","cytosol;other cell component","other molecular function","GMDS","ENSG00000112699; ENSPPAG00000026874; ENSPPYG00000016168; ENSPTRG00000017663","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars","GDP-fucose biosynthesis","",3984.2,3918,3919,3581.9,3324.7,3696.9,1.1148394398076107,0.15683594685142596,0.022395205220710653,1.6498449534999877,0.17212045736926831,0.7641675085534287,951]
["O60551","Glycylpeptide N-tetradecanoyltransferase 2 [OS=Homo sapiens]",20,8,34,4,498,56.9,7.58,109.02,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","NMT2","ENSG00000152465","","Membrane binding and targetting of GAG proteins; Inactivation, recovery and regulation of the phototransduction cascade","",491.9,444.2,458.6,414.8,367.4,2429.6,0.4342424808518586,-1.2034272267960302,0.42327192048823953,0.3733805413098284,0.5917548712411137,0.22785815833436218,5228]
["O60563","Cyclin-T1 [OS=Homo sapiens]",18,11,17,11,726,80.6,8.78,48.91,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","CCNT1","ENSG00000129315","Transcriptional misregulation in cancer","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interactions of Tat with host cellular proteins","Initiation of transcription and translation elongation at the HIV-1 LTR; Male infertility",1934.5,1858.3,1888.6,1881.5,1950,1825.1,1.0043842590955696,0.006311323703420149,0.8547983795097901,0.0681363098240927,0.9029803954093157,0.04432167854361372,6919]
["O60566","Mitotic checkpoint serine/threonine-protein kinase BUB1 beta [OS=Homo sapiens]",20,18,29,18,1050,119.5,5.27,70.87,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","BUB1B","ENSG00000156970","Cell cycle; Human T-cell leukemia virus 1 infection","Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A","Regulation of sister chromatid separation at the metaphase-anaphase transition",2990.2,2946.1,2999.2,3456.6,3177.8,3709.4,0.8638508091803787,-0.21114592074019017,0.03838464206006515,1.415842504869908,0.21449032784175548,0.6685922869741835,1308]
["O60568","Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 [OS=Homo sapiens]",28,18,49,18,738,84.7,6.05,140.33,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;other membranes;ER/Golgi","other molecular function","PLOD3","ENSG00000106397","Lysine degradation; Other types of O-glycan biosynthesis; Metabolic pathways","Collagen biosynthesis and modifying enzymes","VEGFA-VEGFR2 signaling pathway; IL-18 signaling pathway",5483.6,5439.3,5570.9,5670.6,5357.1,7017.2,0.9140421947475464,-0.12966732922332314,0.36860002158497973,0.43344464368493923,0.561153417572301,0.25091838777013203,4801]
["O60573","eukaryotic translation initiation factor 4E type 2 [OS=Homo sapiens]",27,6,12,6,245,28.3,8.88,35.32,"protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF4E2","ENSG00000135930","EGFR tyrosine kinase inhibitor resistance; HIF-1 signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Longevity regulating pathway; Insulin signaling pathway","ISG15 antiviral mechanism","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; EGFR tyrosine kinase inhibitor resistance",1738.4,1638.6,1567.2,2053.8,2003.7,1392.3,0.9072259532459905,-0.14046618246908663,0.4832930255234015,0.3157894721869143,0.6338397135385863,0.19802055335914157,5573]
["O60583-2","Isoform 2 of Cyclin-T2 [OS=Homo sapiens]",4,2,2,2,663,73.6,9.14,4.4,"","","","CCNT2","","","","",28.9,33.1,38.6,36.3,33,33.6,0.9776482021379979,-0.032612677088441705,0.8100507824499401,0.0914877541504026,0.8729963386798307,0.058987577708497156,6782]
["O60610-1","Protein diaphanous homolog 1 [OS=Homo sapiens]",51,64,287,62,1272,141.3,5.41,788.76,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","DIAPH1","ENSG00000131504","Focal adhesion; Regulation of actin cytoskeleton; AGE-RAGE signaling pathway in diabetic complications; Shigellosis","RHOA GTPase cycle; RHOC GTPase cycle; RHO GTPases Activate Formins; RHOB GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; ERBB2 Regulates Cell Motility","Microtubule cytoskeleton regulation; AGE/RAGE pathway; Focal adhesion; Type 2 papillary renal cell carcinoma; Regulation of actin cytoskeleton; G13 signaling pathway",32107.3,31696.4,31774.3,30399,29739.8,31001.7,1.048688563262216,0.06858629378960371,0.01851810391395392,1.7324034831974426,0.1570171943237694,0.8040527871381824,862]
["O60613-1","selenoprotein F [OS=Homo sapiens]",30,4,18,4,162,17.8,5.03,52.18,"","","","","","","","",1794.2,1857.9,1704.1,1766.6,1898.4,2401,0.8829871414441149,-0.17953566619808603,0.2988807471695198,0.524502059759443,0.5253774365228524,0.2795285828709203,4158]
["O60637","Tetraspanin-3 [OS=Homo sapiens]",6,2,4,2,253,28,5.81,9.72,"","plasma membrane;other membranes","","TSPAN3","ENSG00000140391","","","",733.4,710.6,672.5,749.3,750.9,1351.9,0.7420847796360577,-0.43034407761876325,0.2903028388085643,0.5371487172759164,0.5221022265875483,0.2822444546678062,4064]
["O60645","exocyst complex component 3 [OS=Homo sapiens]",18,12,32,12,756,86.8,6.11,85.84,"","","","","","","","",3130.7,3147.5,3067.7,3159.2,2964.1,2478.7,1.0864798883980469,0.11966146934023136,0.29052500866336856,0.5368164771909673,0.5217315204718823,0.2825529245322143,4070]
["O60664-1","Perilipin-3 [OS=Homo sapiens]",58,23,80,23,434,47,5.44,261.45,"transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","PLIN3","ENSG00000105355","","RHOBTB3 ATPase cycle; Late endosomal microautophagy; Triglyceride catabolism; Retrograde transport at the Trans-Golgi-Network; Lipophagy; Chaperone Mediated Autophagy","",10723.9,10602.4,10653.2,10852.4,10944.6,10650.6,0.9855736633834244,-0.020964390207820864,0.1711596241294259,0.7665986759079896,0.4224943237966815,0.37417912141331583,2961]
["O60669","monocarboxylate transporter 2 [OS=Homo sapiens]",5,3,6,3,478,52.2,9.31,15.05,"transport","plasma membrane;other membranes;nucleus","transporter activity","SLC16A7","ENSG00000118596","","Proton-coupled monocarboxylate transport","Male infertility",775.7,779.4,785.3,772.5,884.6,792.5,0.9554212932723709,-0.06579106468051846,0.3525460892085024,0.4527840985861094,0.5552164115546098,0.2555377051211664,4641]
["O60671-1","Cell cycle checkpoint protein RAD1 [OS=Homo sapiens]",20,4,10,4,282,31.8,4.83,32.83,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RAD1","ENSCCAG00000029737; ENSG00000113456; ENSGGOG00000004219; ENSMFAG00000012657; ENSMMUG00000045918; ENSPANG00000024799; ENSPPAG00000028406; ENSPPYG00000015389; ENSPTRG00000016783","Cellular senescence","Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA)","miRNA regulation of DNA damage response; ATR signaling; DNA damage response",943.4,925.5,952.7,959.4,843,813.7,1.0785520431176179,0.10909579220184878,0.20426872593886972,0.6897981198670803,0.4511937497392562,0.34563692514296035,3309]
["O60674","Tyrosine-protein kinase JAK2 [OS=Homo sapiens]",2,2,2,2,1132,130.6,7.21,5.57,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","JAK2","ENSG00000096968","EGFR tyrosine kinase inhibitor resistance; Chemokine signaling pathway; PI3K-Akt signaling pathway; Necroptosis; Signaling pathways regulating pluripotency of stem cells; JAK-STAT signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; Cholinergic synapse; Prolactin signaling pathway; Adipocytokine signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Leishmaniasis; Toxoplasmosis; Tuberculosis; Hepatitis B; Influenza A; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Pathways in cancer; Chemical carcinogenesis; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis","RMTs methylate histone arginines; Potential therapeutics for SARS; Signaling by BRAF and RAF1 fusions; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Signaling by SCF-KIT; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Interleukin-4 and Interleukin-13 signaling; Cyclin D associated events in G1; Factors involved in megakaryocyte development and platelet production; Growth hormone receptor signaling; Interleukin-6 signaling; Signaling by Leptin; Regulation of IFNG signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; RAF activation; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; Prolactin receptor signaling; IL-6-type cytokine receptor ligand interactions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-12 signaling; Interleukin-23 signaling; Interleukin-27 signaling; Erythropoietin activates Phospholipase C gamma (PLCG); Erythropoietin activates STAT5; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants","IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Mesodermal commitment pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Mesodermal commitment pathway; IL-6 signaling pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; PI3K-Akt signaling pathway; Immune response to tuberculosis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; EGF/EGFR signaling pathway; Overview of interferons-mediated signaling pathway; Gastrin signaling pathway; Hepatitis B infection; EGFR tyrosine kinase inhibitor resistance; mBDNF and proBDNF regulation of GABA neurotransmission; 16p11.2 distal deletion syndrome; CCL18 signaling pathway; EPO receptor signaling; Notch signaling pathway (Netpath); Type II interferon signaling (IFNG); Serotonin receptor 2 and STAT3 signaling",35.9,32.6,42.8,39.7,33.7,33.3,1.0431115276476102,0.060893416517534604,0.6959173671379995,0.15744232522637452,0.7879876121474264,0.10348060994484072,6455]
["O60678","protein arginine N-methyltransferase 3 [OS=Homo sapiens]",7,3,4,3,531,59.8,5.35,11.5,"","","","","","","","",194,171.9,176.6,186.8,189.4,173.7,0.9865430078196034,-0.019546149041838188,0.780954938304141,0.10737402452276268,0.849404708938239,0.07088533569261496,6720]
["O60683-1","Peroxisome biogenesis factor 10 [OS=Homo sapiens]",11,2,2,2,326,37,9.99,7.37,"cell organization and biogenesis;transport","other membranes;other cytoplasmic organelle","other molecular function","PEX10","ENSG00000157911","Peroxisome","E3 ubiquitin ligases ubiquitinate target proteins; Peroxisomal protein import","Male infertility",245.2,212.9,231.2,233.5,222.1,712.8,0.5899520712084901,-0.761330342851105,0.3799611109329051,0.4202608512029992,0.5678053076689027,0.2458005521403086,4891]
["O60684","Importin subunit alpha-7 [OS=Homo sapiens]",40,20,64,15,536,60,4.98,212.03,"transport;other biological processes","nucleus;other cell component","other molecular function","KPNA6","ENSG00000025800","Nucleocytoplasmic transport; Influenza A; Chemical carcinogenesis","Assembly of the ORC complex at the origin of replication","",7067.5,6919.9,6896.4,7048.3,7090.5,5137.5,1.0833925597754754,0.11555608821264765,0.45367013711844384,0.343259807270277,0.6123499597781543,0.21300030634764325,5415]
["O60701","UDP-glucose 6-dehydrogenase [OS=Homo sapiens]",27,10,21,10,494,55,7.12,73.03,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes","cytosol;nucleus","other molecular function","UGDH","ENSG00000109814","Pentose and glucuronate interconversions; Ascorbate and aldarate metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars","Formation of the active cofactor, UDP-glucuronate","Glucuronidation",2069.6,2076.9,2034.8,2047.8,1980.8,2457.5,0.9530072000123341,-0.06944098108493645,0.5342062396232328,0.2722910436487654,0.6719176398909324,0.17268395720356564,5811]
["O60704","Protein-tyrosine sulfotransferase 2 [OS=Homo sapiens]",7,2,2,2,377,41.9,9.09,6.91,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","TPST2","ENSG00000128294","","Cytosolic sulfonation of small molecules; Gamma carboxylation, hypusine formation and arylsulfatase activation; Defective F8 sulfation at Y1699","",286.7,289,283,266.2,271.7,232.7,1.1143264988320791,0.15617200577651386,0.07555824901092174,1.1217181149866489,0.2996501584486311,0.5233854883217498,1843]
["O60711-1","Leupaxin [OS=Homo sapiens]",36,11,87,11,386,43.3,6.01,336.59,"cell adhesion;cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","LPXN","ENSG00000110031","","","",6173.9,6006.5,6058.9,7934.7,7964.5,9958.9,0.705361182762848,-0.5035659109242177,0.01941617662755887,1.7118362859125626,0.16035348584274325,0.7949215947264151,885]
["O60725","protein-s-isoprenylcysteine O-methyltransferase [OS=Homo sapiens]",6,2,3,2,284,31.9,7.96,7.07,"protein metabolism;other metabolic processes;transport","other membranes;ER/Golgi","other molecular function","ICMT","ENSG00000116237","Terpenoid backbone biosynthesis","RAS processing; Gamma carboxylation, hypusine formation and arylsulfatase activation","Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome",488.4,595.9,510.9,503.6,502.5,1101.3,0.7569516940305588,-0.4017268594137662,0.4457627338336845,0.35089624174831735,0.6078507129832835,0.2162030695571144,5360]
["O60733","85/88 kDa calcium-independent phospholipase A2 [OS=Homo sapiens]",1,1,1,1,806,89.8,7.27,2.59,"other metabolic processes;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component","other molecular function","PLA2G6","ENSG00000184381","Glycerophospholipid metabolism; Ether lipid metabolism; Arachidonic acid metabolism; Linoleic acid metabolism; alpha-Linolenic acid metabolism; Metabolic pathways; Ras signaling pathway; Vascular smooth muscle contraction; Fc gamma R-mediated phagocytosis; Inflammatory mediator regulation of TRP channels","Role of phospholipids in phagocytosis; COPI-independent Golgi-to-ER retrograde traffic; Acyl chain remodelling of PC; Acyl chain remodelling of PE; Acyl chain remodeling of CL","Eicosanoid synthesis; Spinal cord injury; Ras signaling; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Eicosanoid metabolism via cyclooxygenases (COX); Omega-3 / omega-6 fatty acid synthesis",174.1,167.5,163.8,191.3,201.7,76.9,1.0755479889338158,0.10507189654365952,0.7825665702880724,0.10647870824918339,0.8500191800023067,0.07057127466784056,6729]
["O60749","Sorting nexin-2 [OS=Homo sapiens]",43,20,66,18,519,58.4,5.12,199.82,"cell organization and biogenesis;transport","other membranes;cytosol;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","SNX2","ENSG00000205302","Endocytosis","Golgi Associated Vesicle Biogenesis","",7863,7827.6,7952.4,7414.6,7304.2,6584.4,1.1098332644860867,0.15034294993796787,0.04129356297065979,1.3841176428763788,0.22159666061127195,0.6544367885691723,1362]
["O60759","cytohesin-interacting protein [OS=Homo sapiens]",12,2,3,2,359,40,6.99,8.96,"other biological processes","cytosol;nucleus;other cytoplasmic organelle;other cell component","","CYTIP","ENSG00000115165","","","Amplification and expansion of oncogenic pathways as metastatic traits",198.6,185,203.1,227.7,247.2,187.2,0.8861199214620151,-0.17442613832940465,0.24562238674697828,0.6097320528500839,0.4862551529614475,0.31313578331998543,3692]
["O60762","Dolichol-phosphate mannosyltransferase subunit 1 [OS=Homo sapiens]",47,10,50,10,260,29.6,9.57,123.59,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","DPM1","ENSG00000000419","N-Glycan biosynthesis; Metabolic pathways","Synthesis of dolichyl-phosphate mannose; Defective DPM1 causes DPM1-CDG (CDG-1e); Defective DPM3 causes DPM3-CDG (CDG-1o); Defective DPM2 causes DPM2-CDG (CDG-1u)","VEGFA-VEGFR2 signaling pathway",7141.2,6846.2,6836.8,7693.1,6668,5618.6,1.0422679019204493,0.05972615198804028,0.6670114821267498,0.1758666899494674,0.7673834287524656,0.11498758340075625,6353]
["O60763-1","General vesicular transport factor p115 [OS=Homo sapiens]",48,41,195,41,962,107.8,4.91,605.23,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","","USO1","ENSG00000138768","","COPI-mediated anterograde transport; COPII-mediated vesicle transport; Golgi Cisternae Pericentriolar Stack Reorganization","",21428.5,21276.7,21296.1,21250.5,21834.1,16130,1.0808364828944212,0.11214827778006724,0.42842116755195286,0.368129079567771,0.594857582377892,0.22558699828969714,5264]
["O60783","28S ribosomal protein S14, mitochondrial [OS=Homo sapiens]",12,1,3,1,128,15.1,11.41,11.73,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus","other molecular function","MRPS14","ENSG00000120333","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",32,32,42,31.4,43.4,77.3,0.6969099276791586,-0.5209558882739348,0.33831723297953176,0.4706758798434062,0.5464664432811929,0.26243650150065534,4525]
["O60784","Target of Myb protein 1 [OS=Homo sapiens]",57,19,81,19,492,53.8,4.7,205.96,"transport;signal transduction","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","TOM1","ENSG00000100284","","Neutrophil degranulation","",5183.5,4937.5,5145.6,4893,4972.1,6049.1,0.9593067826218095,-0.05993583752750422,0.6009510421845067,0.2211609073236728,0.7168844732049223,0.14455082577165382,6127]
["O60825-1","6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 [OS=Homo sapiens]",46,19,72,1,505,58.4,8.38,198.67,"other metabolic processes;other biological processes","cytosol;nucleus","kinase activity;other molecular function","PFKFB2","ENSG00000123836; ENSGGOG00000012227; ENSPPAG00000041619; ENSPTRG00000001925","Fructose and mannose metabolism; Metabolic pathways; AMPK signaling pathway; Thyroid hormone signaling pathway","Regulation of glycolysis by fructose 2,6-bisphosphate metabolism","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Thyroid hormones production and peripheral downstream signaling effects",4998.7,4857.9,4919.4,5229.1,4670.4,5312.8,0.971319261387167,-0.041982524149898726,0.5185947079667431,0.28517191933020003,0.6600050009627243,0.1804527737273935,5743]
["O60825-2","Isoform 2 of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 [OS=Homo sapiens]",50,19,71,1,471,54.4,7.56,198.67,"","","","PFKFB2","","","","",130.3,128,134.7,125.4,114.2,134.1,1.0516457051110515,0.07264874876522408,0.3500832021664796,0.45582872722818024,0.5542036224030321,0.25633063989534843,4617]
["O60826","Coiled-coil domain-containing protein 22 [OS=Homo sapiens]",26,14,30,14,627,70.7,6.74,85.37,"transport;other biological processes","cytosol;nucleus;other cytoplasmic organelle","other molecular function","CCDC22","ENSG00000101997","","Neddylation","",2483.7,2475.6,2416.1,2573.7,2576.3,2127.6,1.013438496207541,0.019258536847443792,0.8392676958939281,0.07609949291812264,0.8917295521571044,0.049766840483750956,6879]
["O60828","Polyglutamine-binding protein 1 [OS=Homo sapiens]",19,4,9,4,265,30.5,6.33,27.86,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","PQBP1","ENSG00000102103","Spliceosome","mRNA Splicing - Major Pathway","",571.3,556.4,713.8,937,943.8,1001.3,0.638943825682662,-0.646238996221299,3.052010136307627E-3,2.515414028339975,0.06465838285876072,1.1893751615292765,345]
["O60830-1","Mitochondrial import inner membrane translocase subunit Tim17-B [OS=Homo sapiens]",30,5,15,5,172,18.3,9.03,43.72,"cell organization and biogenesis;transport","other membranes;mitochondrion","transporter activity","TIMM17B","ENSG00000126768; ENSGGOG00000011427; ENSNLEG00000007902; ENSPPAG00000036547; ENSPPYG00000020323; ENSPTRG00000021872","","Mitochondrial protein import","",1920,1895.6,1875.5,1912.9,2016.6,1980.8,0.9629122041182343,-0.054523832080775964,0.0913385956214674,1.0393456701817887,0.3261327774290695,0.48660555096032143,2047]
["O60831","PRA1 family protein 2 [OS=Homo sapiens]",22,3,7,3,178,19.2,9.19,15.69,"transport","other membranes;other cytoplasmic organelle","","PRAF2","ENSG00000243279","","","",344.8,359.4,386.7,325.1,345,536.4,0.904185661002901,-0.14530905597857324,0.6036439449535507,0.21921915134156542,0.7189235120849767,0.14331731274152426,6137]
["O60832-1","H/ACA ribonucleoprotein complex subunit 4 [OS=Homo sapiens]",53,27,113,27,514,57.6,9.42,378.31,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DKC1","ENSG00000130826; ENSGGOG00000001045; ENSPTRG00000022449","Ribosome biogenesis in eukaryotes","rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase","",17191.3,17159,16957.8,17538.2,16910.5,17734.1,0.9832377718328645,-0.02438775587609019,0.32312296426624937,0.4906321756880002,0.5392022250735198,0.2682483243081268,4380]
["O60841","Eukaryotic translation initiation factor 5B [OS=Homo sapiens]",41,55,214,54,1220,138.7,5.49,606.45,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","EIF5B","ENSG00000158417","","GTP hydrolysis and joining of the 60S ribosomal subunit","Translation factors; Ciliary landscape",29169.2,28732.6,28797.1,28722.6,29131.3,18313.4,{"$f":"AVERAGE(S514:U514)/AVERAGE(V514:X514)","v":1.1382693097956735},{"$f":"LOG(Y514,2)","v":0.18684193369066118},{"$f":"TTEST(S514:U514,V514:X514,2,2)","v":0.3777841983763186},{"$f":"-LOG10(AA514)","v":0.4227562113201896},{"$f":"AA514*7309/AE514","v":0.5655929344392693},{"$f":"-LOG10(AC514)","v":0.24749602451738642},4882]
["O60861-1","Isoform 1 of Growth arrest-specific protein 7 [OS=Homo sapiens]",7,2,3,2,412,47.2,7.58,8.59,"","","","GAS7","","","","",278.8,291.7,279.8,580.2,576.6,168,0.6418327294685989,-0.6397307349371808,0.31216211697368024,0.5056198027071489,0.5335811302527196,0.2727995373599163,4276]
["O60869-1","Endothelial differentiation-related factor 1 [OS=Homo sapiens]",10,1,1,1,148,16.4,9.95,2.52,"developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","EDF1; LOC101354658; LOC113248658","ENSBIXG00000009641; ENSBIXG00005005090; ENSBTAG00000030302; ENSCATG00000040060; ENSCCAG00000020655; ENSCJAG00000011166; ENSCSAG00000016077; ENSECAG00000012630; ENSFCAG00000000388; ENSG00000107223; ENSLCNG00005013346; ENSPANG00000026162; ENSPCOG00000009350; ENSRFEG00010005371","","","",231.7,233,215.5,225.5,236.7,207.8,1.0152238805970148,0.02179791047534468,0.753833526386597,0.12272455141691177,0.8316632821674924,0.08005247214178426,6625]
["O60870","DNA/RNA-binding protein KIN17 [OS=Homo sapiens]",13,5,13,5,393,45.3,8.95,36.4,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response","nucleus;other cell component","nucleic acid binding activity;other molecular function","KIN","ENSG00000151657","","Protein methylation","",686.6,694.4,682.6,1031.1,998.5,1108,0.657700152983172,-0.6044980890394749,3.9282060700920684E-4,3.405805737596795,0.02334248631406742,1.6318528871522202,123]
["O60879-2","Isoform 2 of Protein diaphanous homolog 2 [OS=Homo sapiens]",18,20,36,18,1096,124.7,6.43,109.53,"","","","DIAPH2","","","","",3852.8,3799.2,3793.6,3666.3,3801.7,2043.3,1.2033686246885287,0.2670786471252474,0.31765239994018457,0.4980478591171919,0.5369383420820558,0.2700755825144916,4324]
["O60884","DnaJ homolog subfamily A member 2 [OS=Homo sapiens]",37,14,52,14,412,45.7,6.48,156.08,"stress response;other biological processes","other membranes;cytosol","other molecular function","DNAJA2","ENSG00000069345","Protein processing in endoplasmic reticulum","HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand","",6537.6,6315.7,6326.9,6382.7,6463.7,6425.5,0.9952417768875925,-0.006881048683775663,0.7076375921511157,0.15018910392775217,0.7970601265268152,0.09850891620253314,6489]
["O60885-1","Bromodomain-containing protein 4 [OS=Homo sapiens]",4,5,6,5,1362,152.1,9.19,12.26,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","kinase activity;other molecular function","BRD4","ENSG00000141867; ENSPTRG00000010619","","Potential therapeutics for SARS","VEGFA-VEGFR2 signaling pathway; 7q11.23 copy number variation syndrome",308.1,307.5,338.7,2149.6,2182.1,1282.2,0.16998877785496713,-2.5564885877443095,0.006223803836472848,2.205944104013217,0.08902110027549913,1.0505070422639566,511]
["O60888-1","Protein CutA [OS=Homo sapiens]",47,5,48,5,179,19.1,5.5,156.55,"other biological processes","other membranes","other molecular function","CUTA","ENSG00000112514; ENSG00000226492","","","",2629.7,2915.3,2679,2634.6,3118.3,2518.3,0.9942934519779475,-0.008256388741153014,0.9421605691007893,0.02587507562345363,0.9625736091078654,0.016566049552431416,7154]
["O60906","Sphingomyelin phosphodiesterase 2 [OS=Homo sapiens]",6,2,3,2,423,47.6,6.98,6.62,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","SMPD2","ENSG00000135587","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway","Glycosphingolipid metabolism; Ceramide signalling; TNFR1-mediated ceramide production","TNF-alpha signaling pathway; S1P receptor signal transduction",60.4,73,66.6,55.9,68.3,219.4,0.5820721769499417,-0.7807300364763767,0.4149487220911302,0.3820055685621616,0.5858335348201797,0.23222577166004463,5177]
["O60907","F-box-like/WD repeat-containing protein TBL1X [OS=Homo sapiens]",14,7,25,2,577,62.5,6.55,91.11,"protein metabolism;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","TBL1X","ENSG00000101849","Wnt signaling pathway","Heme signaling; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; RORA activates gene expression","Ectoderm differentiation; Ectoderm differentiation; Rett syndrome causing genes",54,47.8,58.2,63.8,61,102.8,0.7029876977152901,-0.508428652531857,0.1784549071547458,0.7484715053103018,0.42849110262616197,0.3680581915248641,3044]
["O60921","checkpoint protein HUS1 [OS=Homo sapiens]",20,4,9,4,280,31.7,6.84,31.78,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","","HUS1","ENSG00000136273","Cellular senescence","Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA)","ATR signaling",356.7,380.8,368.7,358.7,362,307.9,1.075442348823644,0.10493018836346825,0.24171894015799983,0.6166893186290314,0.4832395332644477,0.3158375438068523,3656]
["O60925","prefoldin subunit 1 [OS=Homo sapiens]",8,1,1,1,122,14.2,6.81,3.51,"other biological processes","other cell component","other molecular function","PFDN1","ENSG00000113068","","Prefoldin mediated transfer of substrate  to CCT/TriC","Cellular proteostasis",137.7,133.1,122.1,134.5,170.2,154.9,0.8548738033072236,-0.22621663018742666,0.1212062716729203,0.9164749075420783,0.3654689107497419,0.43714956115235387,2424]
["O60927","Protein phosphatase 1 regulatory subunit 11 [OS=Homo sapiens]",12,1,2,1,126,13.9,7.01,8.98,"protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","enzyme regulator activity;other molecular function","PPP1R11","ENSG00000204619; ENSG00000206501; ENSG00000227720; ENSG00000233314; ENSG00000234058; ENSG00000236560; ENSG00000237403; ENSG00000237829","","","",109,107.1,109.6,154.3,154.1,211.2,0.6268283294842187,-0.6738577110519776,0.027300789716371763,1.563824790156972,0.18718712198589232,0.7277240329635525,1066]
["O60930","Ribonuclease H1 [OS=Homo sapiens]",7,2,3,2,286,32,9.16,10.07,"RNA metabolism OR transcription;other metabolic processes","other cell component","nucleic acid binding activity;other molecular function","RNASEH1","ENSG00000171865","DNA replication","","",368.4,337,354.7,415.2,389.8,467.9,0.8328226883494382,-0.26391872278778794,0.04555018220470516,1.3415098814716688,0.23232817985637824,0.6338981099850403,1433]
["O60934","Nibrin [OS=Homo sapiens]",12,7,14,7,754,84.9,6.9,28.06,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NBN","ENSG00000104320","Homologous recombination; Cellular senescence","Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks","miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM signaling in development and disease ; Breast cancer pathway; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; DNA damage response",1271.4,1316.5,1274.1,1486.5,1639.8,1418.9,0.8496875825046201,-0.23499561366434446,0.027251833295541993,1.564604276383442,0.18720267815518463,0.7276879424584984,1064]
["O60942-1","mRNA-capping enzyme [OS=Homo sapiens]",19,10,25,10,597,68.5,8.13,62.35,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","RNGTT","ENSG00000111880; ENSGGOG00000007863; ENSNLEG00000013064; ENSPPAG00000024828; ENSPTRG00000018413","mRNA surveillance pathway","RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE","mRNA processing; Ciliary landscape; mRNA Processing",1775.2,1850.1,1747.5,1834.7,1902.7,2316.3,0.8875233328377685,-0.17214304667637237,0.21350532879761056,0.6705912811142887,0.4597850466062862,0.33744515721197277,3394]
["O75027-1","ATP-binding cassette sub-family B member 7, mitochondrial [OS=Homo sapiens]",26,17,33,16,752,82.6,9.33,94.31,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","ABCB7","ENSG00000131269","ABC transporters","Mitochondrial ABC transporters; Cytosolic iron-sulfur cluster assembly","",3235.6,3433.3,3533,2939,3176.3,3174.4,1.0981947748581762,0.13513395215867352,0.0610543832309153,1.2142831516262984,0.2683382363408057,0.5713174389618446,1663]
["O75037","Kinesin-like protein KIF21B [OS=Homo sapiens]",8,10,15,9,1637,182.5,7.08,40.29,"other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF21B","ENSG00000116852","","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",845.3,821.4,818.8,1111.7,1013.6,2361,0.5540200164946615,-0.8519899937466375,0.1989996274761225,0.7011477365813276,0.4469847194907742,0.3497073232981946,3254]
["O75044","SLIT-ROBO Rho GTPase-activating protein 2 [OS=Homo sapiens]",31,28,60,28,1071,120.8,6.7,171.11,"","","","","","","","",7912.6,7613.3,7591.7,6965.9,6721.1,6491.6,1.1456493512929542,0.1961655462239401,0.004663616925832965,2.331277130167887,0.07800086066570512,1.1079006052543359,437]
["O75052","Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein [OS=Homo sapiens]",12,5,15,4,506,56.1,6.3,29.74,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","NOS1AP","ENSG00000198929","Circadian entrainment","","Sudden infant death syndrome (SIDS) susceptibility pathways",389.5,408.3,390.7,401.4,400,780.2,0.7514542235710674,-0.41224287289941064,0.3592861780579983,0.4445594900277593,0.5569507264954209,0.2541832252171335,4715]
["O75063","Glycosaminoglycan xylosylkinase [OS=Homo sapiens]",15,5,12,5,409,46.4,6.87,36.6,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;nucleus","kinase activity;other molecular function","FAM20B","ENSG00000116199","","","",803.3,804.9,844.1,863.6,888.8,1116.4,0.8548173452314555,-0.226311912643592,0.1636703717813972,0.7860299310732587,0.4156590505039028,0.38126275878987215,2878]
["O75064","DENN domain-containing protein 4B [OS=Homo sapiens]",4,5,8,5,1496,163.7,7.21,29.61,"other biological processes","cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity","DENND4B","ENSG00000198837","","RAB GEFs exchange GTP for GDP on RABs","",504.3,530.6,489,523.3,483.8,1231.7,0.6806771484723959,-0.5549574181498418,0.3827933830636667,0.4170355780105905,0.5686660237423455,0.24514271889397787,4920]
["O75071","EF-hand calcium-binding domain-containing protein 14 [OS=Homo sapiens]",3,2,2,2,495,55,6.32,2.24,"","","other molecular function","EFCAB14","ENSG00000159658","","","",176.6,175.2,172.6,210.3,222.6,379.4,0.6455742952111289,-0.6313449588207872,0.15274758514888884,0.816025646976094,0.4043578775274279,0.3932340917313843,2761]
["O75083","WD repeat-containing protein 1 [OS=Homo sapiens]",66,28,263,28,606,66.2,6.65,1018.95,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity","WDR1","ENSG00000071127","","Platelet degranulation","Hypertrophy model",29208.9,28863.5,28793.2,28306.9,25728,25594,1.0908803210894538,0.1254928343457116,0.053873099271919876,1.26862803915657,0.25273330075639433,0.5973375306091429,1558]
["O75093-1","Slit homolog 1 protein [OS=Homo sapiens]",1,1,1,1,1534,167.8,6.57,1.87,"cell organization and biogenesis;transport;developmental processes;other biological processes","non-structural extracellular","signal transduction activity or receptor binding;other molecular function","SLIT1","ENSG00000187122","Axon guidance","Regulation of expression of SLITs and ROBOs; Netrin-1 signaling; Regulation of cortical dendrite branching; Regulation of commissural axon pathfinding by SLIT and ROBO","Spinal cord injury",230.2,229.4,248.3,273.9,262.7,391.5,0.762741083934921,-0.39073468437455555,0.15283085852230893,0.8157889472467116,0.40443184103532076,0.39315465960535106,2762]
["O75113","NEDD4-binding protein 1 [OS=Homo sapiens]",19,12,17,12,896,100.3,5.36,60.04,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","N4BP1","ENSG00000102921","","","",858.1,827.2,838.8,937.6,904.2,834.9,0.9429895019987298,-0.08468638496119624,0.18229643128659648,0.7392218331975142,0.4302242868174794,0.3663050766703281,3097]
["O75116","Rho-associated protein kinase 2 [OS=Homo sapiens]",29,34,65,28,1388,160.8,6.02,166.7,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;kinase activity;other molecular function","ROCK2","ENSG00000134318","cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Vascular smooth muscle contraction; Wnt signaling pathway; Axon guidance; Focal adhesion; Tight junction; Platelet activation; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Human cytomegalovirus infection; Pathways in cancer; Proteoglycans in cancer; Lipid and atherosclerosis","RHOA GTPase cycle; RHOB GTPase cycle; RHOC GTPase cycle; G alpha (12/13) signalling events; Potential therapeutics for SARS; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHOBTB1 GTPase cycle; RHOH GTPase cycle","Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Pathogenic Escherichia coli infection; Spinal cord injury; Focal adhesion; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; Wnt signaling; Airway smooth muscle cell contraction; Regulation of actin cytoskeleton; G13 signaling pathway",5327,5282.3,5426.6,5494.7,5485.7,4088.7,1.0641577798275943,0.08971207123297308,0.52986062183477,0.2758383551702027,0.6691000837923867,0.17450891573322955,5788]
["O75122","CLIP-associating protein 2 [OS=Homo sapiens]",29,29,71,1,1294,141,8.47,187.27,"","","","","","","","",15.6,18.5,18.2,16,21.4,30.2,0.7736686390532546,-0.37021230003524275,0.2953064831582078,0.5297270184296798,0.523755177239345,0.28087167107029515,4121]
["O75122-3","Isoform 3 of CLIP-associating protein 2 [OS=Homo sapiens]",24,29,71,1,1515,165.8,8.37,188.79,"","","","","","","","",5415.3,5215.5,5361.1,5824.7,5843.1,7082.7,0.8528785899042691,-0.22958771115103724,0.09406041899157351,1.02659309102346,0.33036405690024545,0.48100720935111385,2081]
["O75127","pentatricopeptide repeat-containing protein 1, mitochondrial [OS=Homo sapiens]",15,8,17,8,700,78.8,8.59,43.17,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","nucleic acid binding activity","PTCD1","ENSG00000106246","","","",1482.4,1393.6,1382.8,1658.4,1671.1,1816.2,0.8276424976193716,-0.27292036857465624,7.7256916698039396E-3,2.1120626284167736,0.10211045282928932,0.9909297978374991,553]
["O75131","Copine-3 [OS=Homo sapiens]",46,20,84,19,537,60.1,5.85,274.59,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","CPNE3","ENSG00000085719","","Neutrophil degranulation; Glycerophospholipid biosynthesis","",10478.3,10306.1,10485.3,9807.3,9514,11112.7,1.0274594203850957,0.039081415643922535,0.6035362945108063,0.2192966078668694,0.7189124472913108,0.143323996923821,6136]
["O75132","Zinc finger BED domain-containing protein 4 [OS=Homo sapiens]",2,2,2,2,1171,130.2,6.83,7.41,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBED4","ENSG00000100426","","","",114.7,124.1,148.3,140.7,137,218.8,0.779657603222558,-0.35908741012342504,0.269706031797175,0.5691093407293991,0.505975715196497,0.29587032705200406,3896]
["O75140-1","Isoform 1 of GATOR complex protein DEPDC5 [OS=Homo sapiens]",8,9,10,9,1572,177.8,6.73,33.77,"","","","DEPDC5","","","","",668.2,652.6,677,700.4,665.7,851.7,0.900802597168365,-0.1507171079260149,0.27154321066874243,0.5661610512987588,0.5075982932935649,0.2944798468106526,3910]
["O75143-1","Autophagy-related protein 13 [OS=Homo sapiens]",17,5,9,5,517,56.5,5.12,27.52,"cell organization and biogenesis;other metabolic processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cell component","other molecular function","ATG13","ENSG00000175224","Autophagy; Autophagy; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration","Macroautophagy","Alzheimer's disease and miRNA effects; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Host-pathogen interaction of human coronaviruses - autophagy; Autophagy; Malignant pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; Senescence and autophagy in cancer",677.3,677.8,657,939.2,911.7,1145.8,0.6714385824406847,-0.574672654818602,0.011479767170508732,1.9400669200903697,0.12320942474192118,0.909356070119182,681]
["O75144-1","ICOS ligand [OS=Homo sapiens]",4,1,1,1,302,33.3,5.31,2.94,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","ICOSLG","ENSG00000160223","Cell adhesion molecules; Intestinal immune network for IgA production","Costimulation by the CD28 family","",61.3,90.7,72.6,88.8,92.6,147,0.6839220462850183,-0.5480961993772037,0.16924717028312383,0.7714785837400004,0.4213309153948747,0.3753766731000604,2936]
["O75145-1","Liprin-alpha-3 [OS=Homo sapiens]",1,2,2,1,1194,133.4,5.68,4.59,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","non-structural extracellular;cytosol;other cell component","","PPFIA3","ENSG00000177380","","Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Receptor-type tyrosine-protein phosphatases","",285.1,290.8,284.6,330,301.1,639.1,0.6774523697055582,-0.5618085778011795,0.2754287816081393,0.5599906790374127,0.5101644614226787,0.29228979806961214,3946]
["O75146","Huntingtin-interacting protein 1-related protein [OS=Homo sapiens]",25,25,37,25,1068,119.3,6.67,110.28,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component","cytoskeletal activity;other molecular function","HIP1R","ENSG00000130787","","Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis","",3498.3,3344.6,3474.6,3500.6,3424.6,5411.7,0.8363122016065624,-0.2578864831696613,0.3600936299126469,0.44358456126758256,0.5566675848205449,0.2544040672568085,4728]
["O75150","E3 ubiquitin-protein ligase BRE1B [OS=Homo sapiens]",39,36,87,33,1001,113.6,6.23,274.24,"protein metabolism;other metabolic processes","nucleus","other molecular function","RNF40","","","","",7380.4,7377.7,7401.7,7649.3,7730.5,8338.4,0.9342951826023898,-0.09804966572720042,0.07536198225720406,1.1228476867538817,0.299359091477122,0.5238075478794453,1840]
["O75151","lysine-specific demethylase phf2 [OS=Homo sapiens]",7,6,6,6,1096,120.7,9.17,14.18,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","other molecular function","PHF2","ENSG00000197724","","HDMs demethylate histones","",272.4,281.6,304.8,321.9,347,450.6,0.7671281822242072,-0.3824604318811867,0.09875825764703045,1.0054265807586877,0.334177826454697,0.4760223700256456,2160]
["O75152","Zinc finger CCCH domain-containing protein 11A [OS=Homo sapiens]",35,26,48,26,810,89.1,8.37,125.72,"other metabolic processes;transport","nucleus","nucleic acid binding activity;other molecular function","ZC3H11A","ENSG00000058673","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","",5813.9,5870.2,5954.2,6431.8,6612.9,5477.3,0.9522891696361084,-0.07052836982773893,0.4528515112410252,0.3440441786056796,0.6122626148095918,0.21306225808441326,5406]
["O75153","Clustered mitochondria protein homolog [OS=Homo sapiens]",24,22,46,22,1309,146.6,6.13,135.35,"cell organization and biogenesis","other cell component","nucleic acid binding activity","CLUH","ENSG00000132361","","","Translation factors",4712.9,4504.3,4444.1,6413.4,6103.6,4640.8,0.7962151324761917,-0.3287698040397415,0.10260680839615767,0.9888238209904794,0.33980659835410804,0.4687681922681614,2207]
["O75157","TSC22 domain family protein 2 [OS=Homo sapiens]",6,5,11,3,780,79.2,5.02,19.03,"stress response;other biological processes","","","TSC22D2","ENSG00000196428","","","",637.7,606.8,597.6,571.1,605.2,538.3,1.0743613670827012,0.10347933299760799,0.13583683747921008,0.8669824381227682,0.3833326042994388,0.4164242403200471,2590]
["O75164-1","Lysine-specific demethylase 4A [OS=Homo sapiens]",12,9,18,9,1064,120.6,5.85,58.62,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","KDM4A","ENSG00000066135","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux","",936.5,957.3,985.4,1137.1,1113.6,1404.9,0.7876135244556297,-0.34444021028889993,0.05197622241483131,1.2841952878209688,0.24894771273263566,0.6038918595558576,1526]
["O75165","DnaJ homolog subfamily C member 13 [OS=Homo sapiens]",30,57,155,57,2243,254.3,6.74,473.49,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","","DNAJC13","ENSG00000138246","","Neutrophil degranulation","",14528,14438.1,14556,14905.2,14569.8,18052.4,0.915726507235826,-0.12701131050594286,0.29529560383846637,0.529743018469758,0.5238630020522697,0.2807822726189195,4120]
["O75167","Phosphatase and actin regulator 2 [OS=Homo sapiens]",2,2,2,1,634,69.7,8.16,3.9,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes","enzyme regulator activity;cytoskeletal activity","PHACTR2","ENSG00000112419","","Platelet degranulation","",40.4,40.9,60.2,52.1,47.1,204.9,0.4653074646497862,-1.1037437633115534,0.3577273154510815,0.4464478965948199,0.5567778851430909,0.25431802295040495,4696]
["O75170","Serine/threonine-protein phosphatase 6 regulatory subunit 2 [OS=Homo sapiens]",25,14,27,14,966,104.9,4.87,59.4,"other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP6R2","ENSG00000100239","","","",995.9,994.4,988.8,1037.9,1065.8,952.8,0.9746769180435138,-0.037004015491582734,0.4908522854087136,0.30904918258916414,0.6392799989401795,0.19430888306151353,5612]
["O75175","CCR4-NOT transcription complex subunit 3 [OS=Homo sapiens]",7,5,14,5,753,81.8,6.2,35.81,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","","CNOT3","ENSG00000088038; ENSG00000273943; ENSG00000274176; ENSG00000274616; ENSG00000274941; ENSG00000275979; ENSG00000276082; ENSG00000277114; ENSG00000277600; ENSG00000277615","RNA degradation","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","",935.6,899.7,935.7,1192.6,1226.6,1051.6,0.7983750144059008,-0.3248615234566076,0.013167026587769557,1.8805122874770634,0.13147240072405422,0.8811654066514824,732]
["O75177","Calcium-responsive transactivator [OS=Homo sapiens]",6,2,2,2,396,43,6.44,5.82,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","SS18L1","ENSG00000184402","","","",158.7,173.1,154.7,218.1,211.6,225.2,0.7428615055733699,-0.42883482604347345,1.1943170134123828E-3,2.9228803809939974,0.038119052624589984,1.4188579014499123,229]
["O75179-1","Ankyrin repeat domain-containing protein 17 [OS=Homo sapiens]",14,29,48,17,2603,274.1,6.52,133.09,"stress response;developmental processes;other biological processes","other membranes;nucleus;other cell component","other molecular function","ANKRD17","ENSG00000132466","","","",4129.1,4179,4155.1,4840.6,4741.1,4272.8,0.8995777545201921,-0.15268010944994967,0.0575610888574151,1.2398709993029402,0.2606654265544281,0.5839165678050189,1614]
["O75182-2","Isoform 2 of Paired amphipathic helix protein Sin3b [OS=Homo sapiens]",8,6,10,5,1130,129.3,6.98,26.85,"","","","SIN3B","","","","",168.5,175.5,173.2,191.9,203.3,184.1,0.8928016571724494,-0.16358838986155233,0.025285558497160274,1.5971274494051306,0.18101091778231582,0.7422952296080679,1021]
["O75190","DnaJ homolog subfamily B member 6 [OS=Homo sapiens]",30,8,18,7,326,36.1,9.16,53.64,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","DNAJB6","ENSG00000105993","","Regulation of HSF1-mediated heat shock response","",1784.8,1721.5,1742.1,1596.8,1618.9,1495.7,1.1139788597868998,0.15572185460793306,0.013306633669569827,1.8759317990438213,0.13232406189236173,0.8783611762440432,735]
["O75191","xylulose kinase [OS=Homo sapiens]",4,2,2,2,536,58.3,5.86,6.13,"other metabolic processes","cytosol","kinase activity;other molecular function","XYLB","ENSG00000093217","Pentose and glucuronate interconversions; Metabolic pathways","Formation of xylulose-5-phosphate","",152.7,164.9,148.3,161.6,138.9,299.8,0.7761119440279861,-0.3656633375184398,0.42532709135520075,0.37127695386872955,0.5931531598388022,0.22683315168734994,5241]
["O75208-1","Ubiquinone biosynthesis protein COQ9, mitochondrial [OS=Homo sapiens]",18,4,13,4,318,35.5,5.94,59.67,"other metabolic processes","other membranes;mitochondrion","other molecular function","COQ9","ENSG00000088682","","Ubiquinol biosynthesis","",843.1,853.2,849,644.7,741.2,613.2,1.2732229503276475,0.3484850674473489,0.00920779215855904,2.0358444923115457,0.11160821374279938,0.9523038425677239,603]
["O75223-1","gamma-glutamylcyclotransferase [OS=Homo sapiens]",54,9,45,9,188,21,5.14,115.66,"cell organization and biogenesis;signal transduction","cytosol","other molecular function","C7orf24; GGCT","ENSG00000006625; ENSGGOG00000024930; ENSPPAG00000031715; ENSPTRG00000019041","Glutathione metabolism; Metabolic pathways","Glutathione synthesis and recycling","Gamma-glutamyl cycle for the biosynthesis and degradation of glutathione, including diseases",5310.2,5106,5238.3,5184.2,4634.5,3910,1.140275481291018,0.1893824098987451,0.16105172742021906,0.7930346126322704,0.4125927359671858,0.3844784224053738,2853]
["O75251","NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [OS=Homo sapiens]",14,3,27,3,213,23.5,9.99,53.49,"cell organization and biogenesis;other metabolic processes;transport","plasma membrane;other membranes;mitochondrion;other cell component","transporter activity;other molecular function","NDUFS7","ENSG00000115286","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",2909.7,2646.6,2777.9,2800.9,2771.1,5203.5,0.7734397475755184,-0.37063918751784586,0.3716177210373463,0.4299035843306291,0.5631668926108158,0.2493628843685387,4823]
["O75306-1","NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [OS=Homo sapiens]",47,17,73,17,463,52.5,7.55,235.08,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion;nucleus","transporter activity;other molecular function","NDUFS2","ENSG00000158864","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",7420.4,7551.6,7722,7397.9,6906.8,7210.3,1.0547989774575877,0.07696807773947335,0.07897320138537874,1.1025202563667846,0.30572835218524,0.5146642844448618,1888]
["O75312","Zinc finger protein ZPR1 [OS=Homo sapiens]",45,15,37,15,459,50.9,4.73,120.57,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ZPR1","ENSG00000109917","","","",3589.4,3459.3,3481.7,3652.9,4076.2,4109.1,0.8895271240560221,-0.16888949710207712,0.04580492561798767,1.339087817767081,0.23297717560325115,0.6326866240173338,1437]
["O75323-1","Protein NipSnap homolog 2 [OS=Homo sapiens]",24,6,16,5,286,33.7,9.36,44.31,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;mitochondrion","","NIPSNAP2","ENSG00000146729","","RHOJ GTPase cycle; RHOH GTPase cycle","",1456.5,1466.2,1427.7,1410.5,1400.6,1710.6,0.9621160183116968,-0.05571722069381673,0.6067637243412007,0.21698039161202806,0.7209943198195149,0.14206815675180287,6151]
["O75330-1","Hyaluronan mediated motility receptor [OS=Homo sapiens]",36,25,38,24,724,84,5.83,108.57,"","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","HMMR","ENSG00000072571","ECM-receptor interaction","AURKA Activation by TPX2; Hyaluronan uptake and degradation","",4353.8,4318.4,4109.9,3954.1,4134.7,4218.1,1.0386124856787655,0.05465747399931688,0.21949330857108468,0.658578715034389,0.4646037047049111,0.3329173314998703,3453]
["O75335-1","Isoform 1 of Liprin-alpha-4 [OS=Homo sapiens]",1,1,1,1,701,78,7.28,2.27,"","","","PPFIA4","","","","",203.2,206.2,183.6,176.2,171,354.6,0.8449700769449986,-0.24302784296880062,0.58276668531763,0.23450528325116304,0.704505739825762,0.15211546420898842,6046]
["O75340","programmed cell death protein 6 [OS=Homo sapiens]",40,6,30,6,191,21.9,5.4,63.06,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PDCD6","ENSG00000249915","","","Epithelial to mesenchymal transition in colorectal cancer",4778.5,4780.3,4626.6,4434.6,4718.8,5267,0.9837036420626334,-0.023704350993763577,0.7692801626613328,0.1139154665194839,0.842347372118604,0.07450877467212376,6675]
["O75347","Tubulin-specific chaperone A [OS=Homo sapiens]",34,5,6,5,108,12.8,5.29,13.87,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","TBCA","ENSG00000171530","","Post-chaperonin tubulin folding pathway","VEGFA-VEGFR2 signaling pathway",726.7,684,562.9,662.4,642.2,1172.1,0.7968667985626036,-0.3275895063220872,0.4046574096766977,0.3929125028378689,0.5799296092798006,0.23662471705183233,5100]
["O75348","V-type proton ATPase subunit G 1 [OS=Homo sapiens]",7,1,1,1,118,13.7,8.79,1.8,"transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle","transporter activity;other molecular function","ATP6V1G1","ENSG00000136888","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis","Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Osteoclast signaling; Proximal tubule transport",177.6,164.3,181.6,155.7,174,213.7,0.9633787265366213,-0.05382502840380416,0.7297373274942107,0.13683343816539953,0.814670860952373,0.08901781720342322,6547]
["O75351","Vacuolar protein sorting-associated protein 4B [OS=Homo sapiens]",58,20,82,16,444,49.3,7.23,209.91,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","VPS4B","ENSG00000119541","Endocytosis; Necroptosis","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)","",8787.3,8913.3,8902.7,9435,9482.8,7210.3,1.0181873155721235,0.026002997943616532,0.843207930550226,0.07406531748019456,0.8950053390054606,0.04817437396487631,6886]
["O75352","Mannose-P-dolichol utilization defect 1 protein [OS=Homo sapiens]",10,2,24,2,247,26.6,8.94,56.6,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","","MPDU1","ENSG00000129255","","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective MPDU1 causes CDG-1f","",1485.4,1597.7,1555.6,1346.7,1400.8,1769.4,{"$f":"AVERAGE(S578:U578)/AVERAGE(V578:X578)","v":1.026965396621577},{"$f":"LOG(Y578,2)","v":0.03838757117558521},{"$f":"TTEST(S578:U578,V578:X578,2,2)","v":0.7813805823050602},{"$f":"-LOG10(AA578)","v":0.10713738541037031},{"$f":"AA578*7309/AE578","v":0.8494884242254478},{"$f":"-LOG10(AC578)","v":0.07084253478112099},6723]
["O75354-1","Ectonucleoside triphosphate diphosphohydrolase 6 [OS=Homo sapiens]",2,1,2,1,484,53.2,9.26,6.59,"other metabolic processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","ENTPD6","ENSG00000197586","Purine metabolism; Pyrimidine metabolism; Metabolic pathways","Phosphate bond hydrolysis by NTPDase proteins","",81,81.1,73,107.4,101.6,173.9,0.61399843301123,-0.7036931211971394,0.10248456792550219,0.9893415255289114,0.3400180240433479,0.46849806079570605,2203]
["O75362","zinc finger protein 217 [OS=Homo sapiens]",5,5,5,4,1048,115.2,8.48,14.96,"other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","ZNF217","ENSG00000171940","","Estrogen-dependent gene expression","",232,252.8,262.7,679.9,793.7,323,0.41606367583212733,-1.265123754556521,0.06959454912130916,1.157424774458999,0.2859283639840633,0.5437427606589511,1779]
["O75367-1","Core histone macro-H2A.1 [OS=Homo sapiens]",48,16,177,16,372,39.6,9.79,596.35,"cell organization and biogenesis;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","H2afy; H2AFY; LOC100466888; LOC101338325; LOC101381952; LOC101564704; LOC102987354; LOC103079324; LOC103663804; LOC106989149; LOC109250833; LOC110591142; LOC111141291; LOC111182462; LOC112404331; LOC112815157; LOC112861289; LOC112917035; LOC113261754; LOC113928700; LOC115516119; LOC116529369; MACROH2A1","ENSAMEG00000017887; ENSCAFG00000001076; ENSCANG00000022762; ENSCJAG00000005818; ENSFCAG00000013924; ENSG00000113648; ENSGGOG00000001707; ENSLCNG00005003680; ENSMLEG00000037795; ENSMNEG00000031666; ENSMPUG00000010011; ENSPCOG00000013464; ENSPCTG00005011747; ENSPPAG00000029258; ENSPTRG00000017256; ENSRBIG00000034425; ENSRROG00000045755; ENSSBOG00000034640; ENSSSUG00005001976; ENSVVUG00000017487","Necroptosis; Neutrophil extracellular trap formation; Alcoholism; Systemic lupus erythematosus","","H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma",28642.4,27979.2,28272,24213.7,25486.6,17375.4,1.2656386739161871,0.33986558979583925,0.07839343508123879,1.1057203050115985,0.3049375290094595,0.515789123228151,1879]
["O75368","SH3 domain-binding glutamic acid-rich-like protein [OS=Homo sapiens]",29,5,14,5,114,12.8,5.25,36.43,"","nucleus;other cell component","other molecular function","SH3BGRL","ENSG00000131171","","","",2454.6,2557.5,2559.4,2685.8,2709.4,3673.7,0.8348862596345752,-0.26034842884341,0.20191826670726506,0.6948243904604308,0.4487140806820919,0.3480303020591125,3289]
["O75369-1","Filamin-B [OS=Homo sapiens]",14,31,65,20,2602,278,5.73,163.33,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","FLNB","ENSG00000136068","MAPK signaling pathway; Focal adhesion; Salmonella infection; Proteoglycans in cancer","ISG15 antiviral mechanism","Focal adhesion; MAPK signaling pathway; VEGFA-VEGFR2 signaling pathway; Ebola virus pathway in host",1812.3,1749.1,1759.5,1703.7,1659.4,6930.7,0.5169033787328294,-0.9520334624134311,0.39713199159585466,0.40106512624784085,0.5762631976521941,0.23937911522157906,5037]
["O75376-1","Nuclear receptor corepressor 1 [OS=Homo sapiens]",8,21,29,21,2440,270,7.11,79.66,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","NCOR1","ENSG00000141027","Endocrine resistance; Thyroid hormone signaling pathway; Transcriptional misregulation in cancer","HDACs deacetylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Transcriptional activation of mitochondrial biogenesis; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Nuclear Receptor transcription pathway; Cytoprotection by HMOX1; Nuclear signaling by ERBB4; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NR1D1 (REV-ERBA) represses gene expression; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis","Androgen receptor signaling pathway; Adipogenesis; Ovarian infertility; MECP2 and associated Rett syndrome; Pathways affected in adenoid cystic carcinoma; Rett syndrome causing genes; 22q11.2 copy number variation syndrome; Notch signaling pathway (Netpath)",3214.1,3265.9,3330.3,3943.6,3983.5,6022,0.7032926855496053,-0.507802881955473,0.11506783199270747,0.9390460694252757,0.35788544001476547,0.44625596981303906,2350]
["O75379-1","Vesicle-associated membrane protein 4 [OS=Homo sapiens]",32,3,4,3,141,16.4,7.34,8.97,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","VAMP4","ENSCATG00000035773; ENSG00000117533; ENSGGOG00000023200; ENSMFAG00000031870; ENSMLEG00000033096; ENSMMUG00000023203; ENSMNEG00000025169; ENSNLEG00000015204; ENSPANG00000022546; ENSPPAG00000028975; ENSPTRG00000001680; ENSRBIG00000031656; ENSRROG00000036404","SNARE interactions in vesicular transport","Retrograde transport at the Trans-Golgi-Network; Cargo recognition for clathrin-mediated endocytosis","",134.2,136.8,133.1,160.8,199,176,0.7541993281075029,-0.4069822296589196,0.017038887650267003,1.7685587606913458,0.15077146469225366,0.8216808461277549,826]
["O75380","NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [OS=Homo sapiens]",29,3,4,3,124,13.7,8.28,14.58,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity;other molecular function","NDUFS6","ENSG00000145494","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",89.2,83.1,95.1,120.1,111.9,121.9,0.7555806725063577,-0.4043422963318776,3.3963785484236895E-3,2.4689839107928098,0.06727406723693427,1.1721523150678972,369]
["O75381-1","Peroxisomal membrane protein PEX14 [OS=Homo sapiens]",41,12,27,12,377,41.2,4.94,82.63,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","PEX14","ENSG00000142655; ENSMFAG00000032533; ENSMMUG00000019979; ENSPANG00000017539; ENSPPAG00000038193; ENSPTRG00000000132","Peroxisome","Peroxisomal protein import; E3 ubiquitin ligases ubiquitinate target proteins; Class I peroxisomal membrane protein import","",2961.8,2837.4,2844.2,3134.3,3222.8,3408.4,0.8850954892222622,-0.17609498500712015,0.014349849781815492,1.8431526452205869,0.1363888843371774,0.8652210231380449,769]
["O75385","Serine/threonine-protein kinase ULK1 [OS=Homo sapiens]",2,2,2,2,1050,112.6,8.79,1.95,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","ULK1","ENSG00000177169","Mitophagy; Autophagy; mTOR signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration","RAB GEFs exchange GTP for GDP on RABs; Macroautophagy; TBC/RABGAPs; Receptor Mediated Mitophagy","Target of rapamycin (TOR) signaling; Alzheimer's disease and miRNA effects; Nanoparticle triggered autophagic cell death; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; 7q11.23 copy number variation syndrome; p53 transcriptional gene network; Malignant pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; Senescence and autophagy in cancer",270.7,277.2,266.8,242.8,233.8,384.4,0.9462253193960511,-0.07974432943156777,0.7679132054565865,0.11468786398074861,0.8416070803242152,0.07489061951542866,6669]
["O75386","Tubby-related protein 3 [OS=Homo sapiens]",2,1,2,1,442,49.6,7.74,4.86,"developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","TULP3","ENSG00000078246","","Hedgehog 'off' state","H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Genes related to primary cilium development (based on CRISPR)",279,275.1,244.7,268.5,277.5,169.8,1.1159541771444537,0.15827778902758824,0.48686751791331306,0.31258919908642463,0.6369276335114382,0.1959099085626161,5587]
["O75390","citrate synthase, mitochondrial [OS=Homo sapiens]",41,17,151,17,466,51.7,8.32,428.26,"other metabolic processes","mitochondrion","other molecular function","CS","ENSG00000062485","Citrate cycle (TCA cycle); Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids","Citric acid cycle (TCA cycle); Mitochondrial protein import","TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Fluoroacetic acid toxicity; TCA cycle (aka Krebs or citric acid cycle)",20006.3,20660.6,20216.4,19051.1,18924.2,21812.9,1.0183163232878727,0.026185780619223168,0.7236351352549739,0.14048035464126357,0.8097135951590025,0.09166856882192113,6532]
["O75396","Vesicle-trafficking protein SEC22b [OS=Homo sapiens]",38,7,51,7,215,24.6,6.92,195.73,"","","","","","","","",4504.8,4662.1,4598.7,4298,4549.9,4692.3,1.0166467260454055,0.023818445051873773,0.5772831238392857,0.23861113837977413,0.7021737979932333,0.15355538050903986,6009]
["O75398","Deformed epidermal autoregulatory factor 1 homolog [OS=Homo sapiens]",1,1,1,1,565,59.3,5.34,2.35,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;nucleus;other cell component","nucleic acid binding activity;other molecular function","DEAF1","ENSG00000177030","","","Sudden infant death syndrome (SIDS) susceptibility pathways",64.6,67.9,56.1,75.4,76.4,45.1,0.9578466226510919,-0.06213343522645718,0.8113962414605258,0.09076700836047527,0.8738021406858676,0.05858689566796901,6787]
["O75400","pre-mRNA-processing factor 40 homolog A [OS=Homo sapiens]",30,24,56,1,957,108.7,7.56,145.1,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","","PRPF40A","ENSG00000196504","Spliceosome","mRNA Splicing - Major Pathway","mRNA processing",99.3,103.6,92.6,106.6,107.9,152,0.8062755798090041,-0.3106550679562794,0.1958854180053717,0.7079978923131286,0.443258984582434,0.3533424527602585,3230]
["O75400-3","Isoform 3 of Pre-mRNA-processing factor 40 homolog A [OS=Homo sapiens]",29,24,60,1,939,106.8,7.43,150.08,"","","","PRPF40A","","","","",8247.3,8079.1,8217.8,8218.2,7747.9,4604.7,1.1931572909172223,0.25478424241978326,0.30822991293711866,0.5111252163861436,0.5322117726570754,0.27391552297618094,4233]
["O75410-1","Transforming acidic coiled-coil-containing protein 1 [OS=Homo sapiens]",52,30,97,27,805,87.7,4.88,317.53,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","TACC1","ENSG00000147526","","","",9461.6,9584.5,9566.3,9714.8,10183.4,9163,0.9845567285590409,-0.022453760621419197,0.6413447738965391,0.19290843983103745,0.7477410994432613,0.1262487477860233,6269]
["O75414","Nucleoside diphosphate kinase 6 [OS=Homo sapiens]",17,3,7,3,186,21.1,8.32,21.18,"other metabolic processes;other biological processes","mitochondrion","kinase activity;other molecular function","NME6","ENSG00000172113","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors","","Pyrimidine metabolism",564.8,547.6,543.2,571.2,530.7,2026,0.5293008088493877,-0.917840236262942,0.37486199704205436,0.42612858548269905,0.5649208940990464,0.24801236220098974,4850]
["O75419","Cell division control protein 45 homolog [OS=Homo sapiens]",3,2,2,2,566,65.5,5.53,4.77,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","CDC45","ENSG00000093009","Cell cycle","Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA; G1/S-Specific Transcription","Cell cycle; Retinoblastoma gene in cancer; G1 to S cell cycle control; 22q11.2 copy number variation syndrome; DNA replication",181.9,172.6,182.1,218.6,205.9,347.2,0.6953479331346378,-0.5241930511475414,0.1582750694861504,0.8005874871418566,0.4106611582798272,0.386516372243657,2817]
["O75420","GRB10-interacting GYF protein 1 [OS=Homo sapiens]",8,6,8,6,1035,114.5,5.39,22.65,"signal transduction","cytosol;other cell component","","GIGYF1","ENSG00000146830","","","",285.2,299.7,323.2,366.4,385.5,676.8,0.6356127948484637,-0.6537799285416536,0.1610361762168288,0.7930765502632607,0.4126975497786823,0.38436810955911566,2852]
["O75427","Leucine-rich repeat and calponin homology domain-containing protein 4 [OS=Homo sapiens]",29,13,29,13,683,73.4,8.22,97.56,"developmental processes","nucleus","","LRCH4","ENSG00000077454","","","",1708.5,1640.8,1673.1,1491.8,1598.6,1369.7,1.1260734064258648,0.17130087682727807,0.05308848461361443,1.2749996712182334,0.2511480479229177,0.6000701930951139,1545]
["O75431","Metaxin-2 [OS=Homo sapiens]",39,7,29,7,263,29.7,6.29,115.23,"cell organization and biogenesis;transport","other membranes;mitochondrion;nucleus;other cell component","","MTX2","ENSG00000128654","","Mitochondrial protein import; Cristae formation","",1619.3,1543.5,1573.8,1666.1,1478.8,2193.3,0.8873028361620023,-0.17250151497918792,0.403824193652424,0.39380766544441226,0.579872501258461,0.2366674858971981,5090]
["O75436-1","Vacuolar protein sorting-associated protein 26A [OS=Homo sapiens]",51,14,42,12,327,38.1,6.57,115.45,"transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","VPS26A","ENSANAG00000022406; ENSCATG00000037809; ENSCCAG00000021117; ENSCJAG00000012907; ENSCSAG00000007798; ENSG00000122958; ENSMFAG00000042937; ENSMMUG00000004101; ENSMNEG00000039163; ENSNLEG00000011548; ENSPANG00000022152; ENSPPAG00000041182; ENSPPYG00000002386; ENSPTRG00000002567; ENSRBIG00000023684; ENSRROG00000006745; ENSSBOG00000030031","Endocytosis","WNT ligand biogenesis and trafficking","",4158.6,4086.5,4073.4,3823.6,3271.8,3597.8,1.151993790446265,0.20413294029018714,0.02890982235983262,1.53895457690013,0.1929697640438508,0.7145107341922943,1095]
["O75438","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [OS=Homo sapiens]",19,1,3,1,58,7,8.92,7.18,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB1","ENSG00000183648","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",283.3,345.3,338.2,266.8,521.1,816.7,0.6025177614358719,-0.7309243241542871,0.2548993972221945,0.5936311915349862,0.49444259402787144,0.305884123771853,3768]
["O75439","mitochondrial-processing peptidase subunit beta [OS=Homo sapiens]",42,17,69,16,489,54.3,6.83,218.05,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport","other membranes;mitochondrion","other molecular function","PMPCB","ENSG00000105819","","Mitochondrial protein import; Processing of SMDT1","",6705.3,6765.1,6886.1,6338.3,5830.4,6872,1.069104602246766,0.09640301466727627,0.22428224000864622,0.6492051150555458,0.4687671982336847,0.32904278548081756,3497]
["O75448","Mediator of RNA polymerase II transcription subunit 24 [OS=Homo sapiens]",14,10,14,10,989,110.2,6.95,41.37,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","MED24","ENSG00000008838","Thyroid hormone signaling pathway","Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","",972,968.2,997.4,891.1,956.1,840,1.093182494790116,0.12853426317930944,0.07460867800614832,1.1272106552217864,0.2976609320671059,0.526278162669645,1832]
["O75449-1","Katanin p60 ATPase-containing subunit A1 [OS=Homo sapiens]",15,8,11,7,491,55.9,6.9,16.05,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KATNA1","ENSG00000186625","","","",1375.6,1336.4,1384,1414.4,1283.5,1140.5,1.0671112963734888,0.09371065259392758,0.3459186930567907,0.46102596856656225,0.5521554329661679,0.2579386502102867,4579]
["O75460","Serine/threonine-protein kinase/endoribonuclease IRE1 [OS=Homo sapiens]",22,15,31,15,977,109.7,6.42,111.1,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","ERN1","ENSG00000178607","Autophagy; Protein processing in endoplasmic reticulum; Apoptosis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Lipid and atherosclerosis","IRE1alpha activates chaperones","Alzheimer's disease and miRNA effects; Corticotropin-releasing hormone signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling pathway; Nonalcoholic fatty liver disease; Unfolded protein response; Alzheimer's disease",2448.7,2603.8,2543.1,2940.8,3198.4,4318.1,0.7263442762472149,-0.4612745688354884,0.08826618680710208,1.054205634989698,0.3206449102252033,0.4939756494896149,2012]
["O75475-1","PC4 and SFRS1-interacting protein [OS=Homo sapiens]",51,28,82,27,530,60.1,9.13,247.61,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PSIP1","ENSG00000164985; ENSGGOG00000016152; ENSPTRG00000020786","","Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection","MECP2 and associated Rett syndrome",11601.5,11745.6,11609.7,11971.4,12573.7,10714.8,0.9914038326824527,-0.012455258732663434,0.8630833826517033,0.06394724498443062,0.9077962935388256,0.042011594779908526,6949]
["O75477","erlin-1 [OS=Homo sapiens]",27,10,23,7,346,38.9,7.87,65.26,"","","","","","","","",1744.7,1830.2,1769.2,1796.5,1707.4,2433.8,0.9000286306145476,-0.15195719945766953,0.4383986056051232,0.35813083586256417,0.6019641946961949,0.2204293401513461,5323]
["O75487","Glypican-4 [OS=Homo sapiens]",10,4,7,4,556,62.4,6.68,26.89,"cell adhesion;cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes","extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","GPC4","ENSG00000076716","Wnt signaling pathway","A tetrasaccharide linker sequence is required for GAG synthesis; HS-GAG biosynthesis; HS-GAG degradation; Defective B4GALT7 causes EDS, progeroid type; Defective B3GAT3 causes JDSSDHD; Defective EXT2 causes exostoses 2; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Defective B3GALT6 causes EDSP2 and SEMDJL1; Retinoid metabolism and transport","Wnt signaling",722.2,716.5,693.9,775.3,921.1,793.6,0.8564658634538153,-0.22353234957907245,0.06309849757009504,1.1999809815607052,0.27096763733244694,0.5670825754253012,1702]
["O75489","NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [OS=Homo sapiens]",63,16,72,16,264,30.2,7.5,211.44,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion;nucleus","transporter activity;other molecular function","NDUFS3","ENSG00000213619; ENSG00000285387","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","RHOG GTPase cycle; Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",8319.7,8141.2,8225.2,8658.4,8690.6,6648.9,1.0286775092820621,0.04079076777046827,0.751845597581448,0.12387133893411907,0.8309752718467871,0.0804118997541278,6613]
["O75494-1","Serine/arginine-rich splicing factor 10 [OS=Homo sapiens]",30,10,43,10,262,31.3,11.27,118.09,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","Srsf10; SRSF10","ENSCATG00000031598; ENSCCAG00000022497; ENSCPOG00000034102; ENSG00000188529; ENSGGOG00000000392; ENSMLEG00000016013; ENSMNEG00000041500; ENSMUSG00000028676; ENSNLEG00000027520; ENSPANG00000021680; ENSPCOG00000022379; ENSPCTG00005007467; ENSPPAG00000032557; ENSPPYG00000001726; ENSPTRG00000044753; ENSRBIG00000028456; ENSRFEG00010001865; ENSRROG00000043248; ENSSBOG00000019550; ENSSSCG00070027414; ENSSTOG00000000956; ENSTSYG00000009439","Spliceosome","mRNA Splicing - Major Pathway; mRNA Splicing - Major Pathway","mRNA processing; mRNA processing; mRNA Processing",6674.7,6626.4,6603.1,6696.7,7399.6,7740.8,0.9114854994481868,-0.13370838984686303,0.10468613083578603,0.9801108512768649,0.34296321393041684,0.4647524596767298,2231]
["O75503","Ceroid-lipofuscinosis neuronal protein 5 [OS=Homo sapiens]",13,3,4,3,358,41.5,7.4,11.35,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CLN5","ENSG00000102805","Lysosome","","",102.4,119.6,103,90.4,99.1,128.5,1.022012578616352,0.03141295263146133,0.8645430890075824,0.06321335652322449,0.9080249227699985,0.041902231134266485,6959]
["O75521","Enoyl-CoA delta isomerase 2, mitochondrial [OS=Homo sapiens]",48,13,45,13,394,43.6,9,154.73,"other metabolic processes","cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","ECI2","ENSG00000198721","Fatty acid degradation; Peroxisome","","",3765.5,3759,3746.1,3618.1,3693.1,3085.9,1.0840138115436035,0.11638313835094004,0.20249258663908296,0.6935908719094273,0.449580290323529,0.3471927365656865,3292]
["O75525-1","KH domain-containing, RNA-binding, signal transduction-associated protein 3 [OS=Homo sapiens]",9,4,17,2,346,38.8,7.61,34.39,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KHDRBS3","ENSCCAG00000031191; ENSG00000131773; ENSGGOG00000000940; ENSRBIG00000036854; ENSRROG00000044792","","PTK6 Regulates Proteins Involved in RNA Processing","",105.5,101.2,116.4,126.9,130.9,228.7,0.6641315519013361,-0.5904590544031101,0.18025283185110014,0.7441179035980173,0.42942240808334126,0.3671152969909877,3068]
["O75530","Polycomb protein EED [OS=Homo sapiens]",20,7,11,7,441,50.2,7.03,34.57,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","EED","ENSG00000074266","","Transcriptional Regulation by E2F6; HCMV Early Events; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; PKMTs methylate histone lysines; PRC2 methylates histones and DNA; Defective pyroptosis","Histone modifications; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Malignant pleural mesothelioma",1054.9,1053.2,1053.1,1224,1058,1029.6,0.9545838869428676,-0.06705611050207654,0.45475619235649983,0.3422213784921912,0.6133627993972425,0.21228256762060915,5419]
["O75531","Barrier-to-autointegration factor [OS=Homo sapiens]",30,3,4,3,89,10.1,6.09,5.01,"cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","BANF1","ENSG00000175334","","Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Nuclear Envelope Breakdown; Initiation of Nuclear Envelope (NE) Reformation","Envelope proteins and their potential roles in EDMD physiopathology; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy",272.3,251.7,248.1,227.2,247.3,164.6,1.208105147864184,0.27274602560716055,0.16359851515448218,0.7862206423709384,0.41562097576090035,0.38130254237729144,2877]
["O75533-1","splicing factor 3B subunit 1 [OS=Homo sapiens]",49,53,229,53,1304,145.7,7.09,699.58,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","LOC101357717; LOC111145177; Sf3b1; SF3B1","ENSANAG00000021577; ENSCANG00000029415; ENSCATG00000035735; ENSCCAG00000020506; ENSCGRG00001016990; ENSCGRG00015028775; ENSCJAG00000003902; ENSCSAG00000011505; ENSDLEG00000016863; ENSFCAG00000005038; ENSG00000115524; ENSLAFG00000001956; ENSLCNG00005009987; ENSMMNG00015005194; ENSMMUG00000022430; ENSMNEG00000042333; ENSMPUG00000007799; ENSMUSG00000025982; ENSNLEG00000006861; ENSPANG00000013417; ENSPCTG00005000567; ENSPPAG00000035007; ENSRNOG00000013516; ENSRROG00000031308; ENSSBOG00000020080; ENSSSCG00000016075; ENSSSCG00070023758; ENSSSUG00005005995; ENSSTOG00000011034; ENSUMAG00000020945","Spliceosome","B-WICH complex positively regulates rRNA expression; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; mRNA Splicing - Major Pathway; B-WICH complex positively regulates rRNA expression; mRNA Splicing - Minor Pathway; mRNA Splicing - Major Pathway; B-WICH complex positively regulates rRNA expression; mRNA Splicing - Minor Pathway","mRNA processing; mRNA processing; mRNA processing",26130.1,26166.3,26344.4,30282.9,29921.9,30516.4,0.8668403857091834,-0.2061617253677653,2.6458135231459135E-5,4.577440768131362,0.008057604600280618,2.0937940479589954,24]
["O75534","cold shock domain-containing protein E1 [OS=Homo sapiens]",39,32,122,32,798,88.8,6.25,346.46,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","nucleic acid binding activity","CSDE1","ENSG00000009307","","","",17454.3,17276.2,17570.4,22128.8,21274.5,18451.9,0.8455376427527516,-0.24205911103407093,0.046013158114210834,1.3371179579000447,0.23371103033826754,0.6313207899526769,1439]
["O75554","WW domain-binding protein 4 [OS=Homo sapiens]",5,2,2,2,376,42.5,5.57,5.48,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","WBP4","ENSG00000120688","","mRNA Splicing - Major Pathway","",270.1,295.1,271,347.1,344.6,448.2,0.7335731204491622,-0.4469873181479001,0.04479927915016143,1.3487289740292185,0.2310782860328369,0.6362408623927059,1417]
["O75558","syntaxin-11 [OS=Homo sapiens]",5,1,4,1,287,33.2,6.55,17.41,"cell-cell signaling;cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","STX11","ENSG00000135604","SNARE interactions in vesicular transport","","",183.5,228.8,218.9,201.2,219,241.1,0.9544835929230305,-0.0672076962230726,0.6060284420369577,0.21750699311119892,0.7208237400891985,0.14217091844969879,6145]
["O75569-1","Interferon-inducible double-stranded RNA-dependent protein kinase activator A [OS=Homo sapiens]",29,8,30,8,313,34.4,8.41,86.74,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;kinase activity;other molecular function","PRKRA","ENSCATG00000032736; ENSG00000180228; ENSMNEG00000031681; ENSPANG00000001046; ENSPTRG00000012688","","MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis","VEGFA-VEGFR2 signaling pathway; Ebola virus pathway in host",3946.2,3756,3793.2,3353.5,3310.7,3951.7,1.0828474269727484,0.11482998176780977,0.24427785412821715,0.6121159037423562,0.48503853187262674,0.31422375930505,3681]
["O75570","Peptide chain release factor 1, mitochondrial [OS=Homo sapiens]",6,2,3,2,445,52.3,8.5,7.44,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","mitochondrion","nucleic acid binding activity","MTRF1","ENSG00000120662","","","",199.5,215,203.1,159,187.2,79.5,1.4507869391590322,0.5368356624863729,0.12110974835073793,0.9168208982727929,0.36532858055944845,0.43731635052632606,2423]
["O75582-1","Ribosomal protein S6 kinase alpha-5 [OS=Homo sapiens]",3,2,2,2,802,89.8,7.11,4.81,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","kinase activity;other molecular function","RPS6KA5","ENSG00000100784; ENSGGOG00000004254; ENSPPAG00000038077; ENSPTRG00000006631","MAPK signaling pathway; Adrenergic signaling in cardiomyocytes; TNF signaling pathway; Circadian entrainment; Neurotrophin signaling pathway; Shigellosis; Pathways in cancer; MicroRNAs in cancer; Bladder cancer","Recycling pathway of L1; NCAM signaling for neurite out-growth; ERK/MAPK targets; CREB phosphorylation; CD209 (DC-SIGN) signaling","Brain-derived neurotrophic factor (BDNF) signaling pathway; Interleukin-1 (IL-1) structural pathway; Bladder cancer; MAPK signaling pathway; ERK pathway in Huntington's disease; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; p38 MAPK signaling pathway; EGF/EGFR signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Insulin signaling; Malignant pleural mesothelioma; Interferon type I signaling pathways; Serotonin receptor 4/6/7 and NR3C signaling; EGFR1 signaling pathway; MAPK signaling pathway; p38 MAPK signaling pathway",96.9,90.3,94,96.9,107.3,78.4,0.9950460014154281,-0.0071648712614042,0.9596290220015133,0.017896626164277143,0.9741567391401473,0.011371160711572657,7200]
["O75586","Mediator of RNA polymerase II transcription subunit 6 [OS=Homo sapiens]",13,4,4,4,246,28.4,8.62,8.85,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MED6","ENSG00000133997","","Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","",750.8,742.3,706.2,761.2,780.3,433.3,1.113682398217541,0.15533786118261644,0.5455284624724348,0.26318258554814256,0.6804210805820863,0.1672222396822603,5860]
["O75592-1","E3 ubiquitin-protein ligase MYCBP2 [OS=Homo sapiens]",18,71,138,1,4640,509.8,7.03,376.42,"","","","","","","","",90.8,107.2,99.8,92.7,85.7,60.1,1.248637316561845,0.3203544876892261,0.1463207189452706,0.8346941736251556,0.3978638894237287,0.4002654761229703,2688]
["O75592-2","Isoform 2 of E3 ubiquitin-protein ligase MYCBP2 [OS=Homo sapiens]",18,71,138,1,4637,509.4,7.03,374.77,"","","","","","","","",14126.4,13864.5,14072,14164.2,14023.6,17951.4,0.9116521309428858,-0.1334446703912167,0.35127001721659434,0.45435891799360145,0.554521070374965,0.25608194712758164,4630]
["O75607","Nucleoplasmin-3 [OS=Homo sapiens]",44,5,34,5,178,19.3,4.63,111.29,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","NPM3","ENSG00000107833","","","",2501.4,2500.6,2470.4,2851.6,2587.8,2784.3,0.9086420954071767,-0.1382159510287043,0.034897339112349074,1.4572076863038474,0.20787665164805166,0.6821942871468788,1227]
["O75608","Acyl-protein thioesterase 1 [OS=Homo sapiens]",49,8,37,8,230,24.7,6.77,117.04,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","LYPLA1","ENSG00000120992","Glycerophospholipid metabolism; Choline metabolism in cancer","RAS processing; eNOS activation","",4581.6,4754.4,4682.9,4325.1,4437.5,4005.5,1.0979628918946436,0.1348292960696661,0.039766807512757824,1.4004792728622661,0.21853804218853154,0.6604729519453789,1330]
["O75616-1","GTPase Era, mitochondrial [OS=Homo sapiens]",24,7,15,7,437,48.3,8.84,51.11,"cell organization and biogenesis","other membranes;cytosol;mitochondrion","translation activity;nucleic acid binding activity;other molecular function","ERAL1","ENSG00000132591","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Integrated breast cancer pathway",1287.2,1303.6,1294.8,1177.6,1257.3,1558,0.9731273009592027,-0.039299549439675875,0.773071317090444,0.11178043985895328,0.8448532082257858,0.07321874240594026,6688]
["O75626-1","PR domain zinc finger protein 1 [OS=Homo sapiens]",5,4,9,3,825,91.7,8.48,18.45,"cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","PRDM1","ENSG00000057657","","STAT3 nuclear events downstream of ALK signaling; Regulation of TP53 Expression","Nucleotide-binding oligomerization domain (NOD) pathway; Vitamin D receptor pathway; IL-6 signaling pathway; Overview of leukocyte-intrinsic Hippo pathway functions",292.6,285.8,281.9,561.4,636.4,576.9,0.48475798726545344,-1.0446634253467815,1.8966989558531874E-4,3.7220015948819722,0.01824075351096177,1.7389572252787906,76]
["O75643-1","U5 small nuclear ribonucleoprotein 200 kDa helicase [OS=Homo sapiens]",42,80,293,79,2136,244.4,6.06,888.7,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","SNRNP200","ENSCATG00000015790; ENSG00000144028; ENSGGOG00000005174; ENSMLEG00000019083; ENSPPAG00000041559; ENSPPYG00000012068; ENSPTRG00000012230; ENSRBIG00000044690; ENSRROG00000037952","Spliceosome","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","",34378.6,34279,34659.4,35500,35005.1,29160.1,1.036640672973114,0.05191590460937165,0.5826651243918703,0.23458097596759414,0.7046160480112806,0.15204746975060895,6044]
["O75648-1","Mitochondrial tRNA-specific 2-thiouridylase 1 [OS=Homo sapiens]",33,12,22,12,421,47.7,8.03,61.55,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","nucleic acid binding activity;other molecular function","TRMU","ENSG00000100416","","tRNA modification in the mitochondrion","",1841.1,1745.8,1772.2,1629.2,1459.8,1880,1.0785067417991547,0.10903519488483626,0.35805554172228193,0.4460496001926059,0.5563409767109181,0.254658951376715,4704]
["O75663","TIP41-like protein [OS=Homo sapiens]",33,9,38,9,272,31.4,5.91,107.7,"stress response;signal transduction;other biological processes","cytosol","","TIPRL","ENSG00000143155","","","Ciliary landscape",5312.5,5148.9,5000.1,5484.6,5165.1,4674,1.008992606224345,0.012915602588419011,0.864451415506504,0.06325941022158901,0.9080591256017587,0.04188587274918621,6958]
["O75665","Oral-facial-digital syndrome 1 protein [OS=Homo sapiens]",4,4,4,4,1012,116.6,6.1,14.19,"cell organization and biogenesis;transport;developmental processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","OFD1","ENSG00000046651","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Hedgehog 'off' state","Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies",289.2,306.2,281,387.9,309.6,310.8,0.8691857582068829,-0.20226355903893545,0.17806699780595694,0.7494165634051464,0.4278407912438328,0.368717811238153,3042]
["O75674","TOM1-like protein 1 [OS=Homo sapiens]",5,1,2,1,476,53,5.24,10.18,"protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","TOM1L1","ENSG00000141198","","","",39.4,44.6,44.9,43.3,65.3,97.7,0.6248182258846341,-0.6784915575248336,0.17998351935009807,0.7447672603577823,0.4299018114149891,0.3666307249553894,3060]
["O75676","Ribosomal protein S6 kinase alpha-4 [OS=Homo sapiens]",9,7,8,7,772,85.6,8.28,21.95,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","RPS6KA4","ENSG00000162302","MAPK signaling pathway; TNF signaling pathway","Recycling pathway of L1","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Translation inhibitors in chronically activated PDGFRA cells; Insulin signaling; Interferon type I signaling pathways",691.1,678.1,706.2,628.6,711.3,819,0.9613228959192183,-0.056906999894842575,0.6436166479481826,0.19137273085871037,0.7499113789021628,0.1249900565120717,6273]
["O75683","Surfeit locus protein 6 [OS=Homo sapiens]",17,3,6,3,361,41.4,10.64,16.61,"other biological processes","nucleus;other cell component","nucleic acid binding activity","SURF6","ENSG00000148296; ENSG00000281309","","","",47.1,57.5,51,107.4,111.5,148,0.4240937585173072,-1.237544844262351,6.032862537683082E-3,2.219476570225754,0.08854255479503141,1.0528479511014988,498]
["O75688","Protein phosphatase 1B [OS=Homo sapiens]",30,12,32,1,479,52.6,5.05,85.91,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;nucleus","other molecular function","PPM1B","ENSG00000138032","MAPK signaling pathway","ISG15 antiviral mechanism; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants","MAPK signaling pathway",2791.3,2766.5,2689.7,2757.5,2841.6,2556.3,1.0112931309316526,0.01620123388320245,0.7501733393868861,0.12483837442003853,0.8297543791735398,0.08105044684839136,6608]
["O75688-2","Isoform Beta-2 of Protein phosphatase 1B [OS=Homo sapiens]",36,12,32,1,387,42.7,5.2,78.89,"","","","PPM1B","","","","",192.8,185.5,179.8,193.8,197.4,280.3,0.8311243484735666,-0.2668637532644586,0.2554216087173662,0.5927423641214105,0.4949301532649071,0.3054560863027282,3772]
["O75691","Small subunit processome component 20 homolog [OS=Homo sapiens]",11,23,31,23,2785,318.2,7.39,92.85,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;nucleus;other cell component","","UTP20","ENSG00000120800","","rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol","",2708.4,2764.1,2698.1,5034.3,5337.5,4439.7,0.5516389292104108,-0.8582038233200132,1.1144394914113546E-3,2.952943506600111,0.037364395608832986,1.4275420383207427,218]
["O75694","nuclear pore complex protein nup155 [OS=Homo sapiens]",25,26,67,26,1391,155.1,6.16,198.87,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus","other molecular function","NUP155","ENSG00000113569","Nucleocytoplasmic transport; Amyotrophic lateral sclerosis","HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation","",5872.2,5827.5,6005.7,5660,5298.9,4918.9,1.115104107621963,0.15717840838636668,0.050738753343339604,1.2946602076456186,0.24723303212431277,0.6068935048173268,1500]
["O75695","Protein XRP2 [OS=Homo sapiens]",31,9,25,9,350,39.6,5.12,60.43,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","RP2","ENSG00000102218","","Trafficking of myristoylated proteins to the cilium","Joubert syndrome; Ciliopathies",2432.1,2648.8,2502.8,2028.4,2125.4,2211,{"$f":"AVERAGE(S642:U642)/AVERAGE(V642:X642)","v":1.1915064102564104},{"$f":"LOG(Y642,2)","v":0.25278671319017043},{"$f":"TTEST(S642:U642,V642:X642,2,2)","v":0.007997618489366289},{"$f":"-LOG10(AA642)","v":2.097039316871021},{"$f":"AA642*7309/AE642","v":0.10401173227540605},{"$f":"-LOG10(AC642)","v":0.9829176705561092},562]
["O75717","WD repeat and HMG-box DNA-binding protein 1 [OS=Homo sapiens]",16,12,13,12,1129,125.9,5.62,27.54,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response","nucleus;other cell component","nucleic acid binding activity;other molecular function","WDHD1","ENSG00000198554","","","Mesodermal commitment pathway",1189.9,1195.9,1305.6,1235.9,1365.9,1920.1,0.816338264888653,-0.29276101137347504,0.2637916605632612,0.5787389382385014,0.5011835838463415,0.30000316266134397,3847]
["O75718","Cartilage-associated protein [OS=Homo sapiens]",17,6,7,6,401,46.5,5.73,22.1,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;ER/Golgi;other cell component","","CRTAP","ENSG00000170275","","Collagen biosynthesis and modifying enzymes","Type I collagen synthesis in the context of osteogenesis imperfecta",432.7,406.2,410.1,425.9,421.3,758.5,0.7778538954972909,-0.3624288960204974,0.34805424185236,0.45835306898020145,0.5527875822900694,0.2574417214288531,4602]
["O75746","Calcium-binding mitochondrial carrier protein Aralar1 [OS=Homo sapiens]",27,17,28,12,678,74.7,8.38,83.01,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","SLC25A12","ENSG00000115840","","Mitochondrial protein import; Gluconeogenesis; Aspartate and asparagine metabolism","",3742.6,3761.1,3840.2,3441.1,3498,5925.1,0.8818193125106886,-0.18144502147385247,0.5696730142787054,0.24437435282246606,0.6972103250775382,0.15663618999148088,5972]
["O75787","Renin receptor [OS=Homo sapiens]",12,3,6,3,350,39,6.1,20.4,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ATP6AP2","ENSG00000182220","Renin-angiotensin system","Neutrophil degranulation; Metabolism of Angiotensinogen to Angiotensins","ACE inhibitor pathway; Oxidative phosphorylation",216.5,238.7,241.3,217.2,219.8,699.8,0.6126847290640394,-0.7067832017541652,0.4125644852554989,0.38450816007932176,0.5842731685201398,0.23338405726530062,5161]
["O75792","Ribonuclease H2 subunit A [OS=Homo sapiens]",25,7,14,7,299,33.4,5.25,47.15,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RNASEH2A","ENSG00000104889","DNA replication","","",1144.8,1180.9,1166,1261.8,1300.3,1489,0.8619140480363358,-0.2143840871210482,0.05836531095871931,1.2338451963001558,0.26219548727552516,0.5813747873530416,1627]
["O75794","Cell division cycle protein 123 homolog [OS=Homo sapiens]",24,6,16,6,336,39.1,4.81,41.87,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","other cell component","","CDC123","ENSG00000151465","","","",792.3,829.7,783,1634.7,1621,1726.7,0.482699100834939,-1.0508039555342703,1.8537025953186668E-5,4.7319599420214224,0.006774356134592067,2.169131975801431,20]
["O75795","UDP-glucuronosyltransferase 2B17 [OS=Homo sapiens]",11,6,14,6,530,61.1,8.54,31.24,"other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","UGT2B17","ENSG00000197888","Pentose and glucuronate interconversions; Ascorbate and aldarate metabolism; Steroid hormone biosynthesis; Retinol metabolism; Porphyrin and chlorophyll metabolism; Metabolism of xenobiotics by cytochrome P450; Drug metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors; Bile secretion; Chemical carcinogenesis; Chemical carcinogenesis","Glucuronidation","Glucuronidation; Metapathway biotransformation Phase I and II",985.9,1009.3,1080.7,1013,962.9,3682.9,0.5435604721849155,-0.8794875480098744,0.39239571939770745,0.40627573893759084,0.5742932144729362,0.24086631506894685,4994]
["O75808-1","Calpain-15 [OS=Homo sapiens]",5,3,3,3,1086,117.2,6.71,12.14,"protein metabolism","other cell component","other molecular function","CAPN15","ENSG00000103326","","Degradation of the extracellular matrix","",107.7,117.3,117.4,138.4,142.6,210.4,0.6967846967846968,-0.5212151559610179,0.10263064665605862,0.9887229346802581,0.3397316106925419,0.4688640418534464,2208]
["O75817","Ribonuclease P protein subunit p20 [OS=Homo sapiens]",11,1,3,1,140,15.6,8.94,12.21,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POP7","ENSG00000172336","Ribosome biogenesis in eukaryotes","tRNA processing in the nucleus","",255.9,252.7,248.7,335.9,323.8,584.1,0.6088599453288308,-0.7158176884585947,0.12855737632476427,0.8909029994938125,0.3736086932634998,0.4275830270017857,2515]
["O75818-1","Ribonuclease P protein subunit p40 [OS=Homo sapiens]",8,2,3,2,363,41.8,6.67,14.23,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RPP40","ENSG00000124787","Ribosome biogenesis in eukaryotes","tRNA processing in the nucleus; Major pathway of rRNA processing in the nucleolus and cytosol","",429,474.9,511.6,446.8,487,501,0.986548647895177,-0.019537901164415106,0.8347052971037605,0.07846683042395987,0.8890791338576779,0.05105958226014146,6862]
["O75820-1","Zinc finger protein 189 [OS=Homo sapiens]",7,3,6,1,626,72.9,8.5,8.26,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF189","ENSG00000136870; ENSGGOG00000003650; ENSPPAG00000034345; ENSPPYG00000019452; ENSPTRG00000021200","Herpes simplex virus 1 infection","Generic Transcription Pathway","",14.1,10.6,15.9,18.5,15.2,19.3,0.7660377358490565,-0.3845126322653854,0.10749585020157619,0.9686083010445897,0.3462702376039314,0.4605848350455528,2269]
["O75821","Eukaryotic translation initiation factor 3 subunit G [OS=Homo sapiens]",57,20,77,20,320,35.6,6.13,246.58,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity","EIF3G","ENSG00000130811","","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell",9216.6,8863.8,9047.1,10523.9,10441.8,9435.6,0.8923138155276257,-0.1643769178307629,0.04015654904189016,1.3962436164920529,0.21968878514010118,0.6581921127476067,1336]
["O75822","Eukaryotic translation initiation factor 3 subunit J [OS=Homo sapiens]",32,9,27,9,258,29,4.83,70.19,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3J","ENSG00000104131","","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell",2130.3,1893.7,5889.3,4235.1,2742.7,1239.7,1.206364466078491,0.2706658392171042,0.7348629953364586,0.1337936213450861,0.8182683779576745,0.08710423184216878,6564]
["O75828","Carbonyl reductase [NADPH] 3 [OS=Homo sapiens]",43,10,31,6,277,30.8,6.18,97.68,"other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","CBR3","ENSG00000159231","Arachidonic acid metabolism; Metabolism of xenobiotics by cytochrome P450; Metabolic pathways","Phase I - Functionalization of compounds","Nuclear receptors meta-pathway; NRF2 pathway",1064.9,1140.1,1060.2,986.2,1054.3,967.3,1.0855774985038897,0.11846272246733432,0.08116151521769319,1.0906498536478049,0.3091242911548304,0.5098668664993035,1919]
["O75832","26S proteasome non-ATPase regulatory subunit 10 [OS=Homo sapiens]",54,9,38,9,226,24.4,6.1,130.27,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","PSMD10","ENSG00000101843","","Degradation of DVL; Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Parkin-ubiquitin proteasomal system pathway",3957.6,4037,3810.1,3896.7,3581.6,7583.3,0.7837613533754715,-0.3515136582934449,0.4461989840329614,0.3504714229122909,0.6079918669457336,0.2161022302078792,5364]
["O75843","AP-1 complex subunit gamma-like 2 [OS=Homo sapiens]",5,4,6,4,785,87.1,6.55,14.17,"transport","other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","AP1G2","ENSG00000213983","Lysosome; Human immunodeficiency virus 1 infection","Lysosome Vesicle Biogenesis","",500.3,498.5,504.9,534.2,524.9,860.7,0.7832586727784144,-0.35243925569143253,0.277482229912603,0.5567648240656606,0.5118923822390751,0.2908213333842159,3962]
["O75844","caax prenyl protease 1 homolog [OS=Homo sapiens]",31,14,57,14,475,54.8,7.49,155.37,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZMPSTE24","ENSG00000084073","Terpenoid backbone biosynthesis","","Adipogenesis; Lamin A-processing pathway; Nephrotic syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy",6772.4,7096.4,7146.3,5900.9,6486.7,3979.5,1.2839843344269908,0.3606276006047917,0.11324050035800345,0.9459982203539163,0.3552252433977027,0.4494961794959623,2330]
["O75865-1","Trafficking protein particle complex subunit 6A [OS=Homo sapiens]",6,1,1,1,159,17.6,5.26,2.3,"cell organization and biogenesis;transport;other biological processes","cytosol;ER/Golgi;other cell component","","TRAPPC6A","ENSG00000007255","","RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport","",27.4,35.3,30.4,32.7,26.5,20.4,1.1695979899497488,0.226012737015145,0.3475550425108872,0.4589764061364557,0.5528356486859792,0.25740395997461274,4595]
["O75874","Isocitrate dehydrogenase [NADP] cytoplasmic [OS=Homo sapiens]",52,22,138,21,414,46.6,7.01,357.16,"other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","IDH1","ENSG00000138413","Citrate cycle (TCA cycle); Glutathione metabolism; Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids; Peroxisome; Central carbon metabolism in cancer","Peroxisomal protein import; Neutrophil degranulation; Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate; NADPH regeneration","Glutathione metabolism; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism",17340.6,17419.8,17251.8,16471.9,16563,15304.6,1.0759772029085943,0.10564751135259193,0.03992909052157841,1.3987105817655467,0.21910039235902146,0.6593568447158562,1332]
["O75879","Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial [OS=Homo sapiens]",11,5,11,5,557,61.8,8.63,26.29,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","other molecular function","GATB","ENSG00000059691","Aminoacyl-tRNA biosynthesis; Metabolic pathways","","",754.7,815,787.6,777.3,836.9,765.8,0.9904621848739497,-0.013826199768823278,0.8010086947586254,0.09636276972700061,0.8650373153059683,0.06296515787399473,6768]
["O75880","Protein SCO1 homolog, mitochondrial [OS=Homo sapiens]",5,2,5,2,301,33.8,8.88,12.22,"cell organization and biogenesis;other biological processes","other membranes;cytoskeleton;mitochondrion","other molecular function","SCO1","ENSG00000133028","","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis",981.2,1007.4,982.8,968.9,1023.5,703.3,1.1022739919130466,0.14048287875659143,0.40692683832736243,0.3904836658776091,0.5810174372601469,0.23581083354388155,5119]
["O75882-1","Attractin [OS=Homo sapiens]",1,3,3,3,1429,158.4,7.31,6.16,"cell adhesion;stress response;developmental processes;other biological processes","extracellular matrix;plasma membrane;other membranes;other cell component","other molecular function","ATRN","ENSG00000088812","","","",459.4,455.7,436.8,502.7,528.6,399.5,0.9448560246016213,-0.08183358398526676,0.5472306469095797,0.26182958853389654,0.6817298105099912,0.16638771486625517,5867]
["O75884-1","Putative hydrolase RBBP9 [OS=Homo sapiens]",16,3,3,3,186,21,6.2,8.55,"other biological processes","nucleus","other molecular function","RBBP9","ENSG00000089050; ENSPPAG00000038694; ENSPTRG00000013289","","","",507.7,486.5,518.3,629.3,542.8,1616.2,0.5424452175160492,-0.8824506502495091,0.2845002691336333,0.5459173184316638,0.5171381415313916,0.286393429650602,4021]
["O75886","Signal transducing adapter molecule 2 [OS=Homo sapiens]",17,8,15,7,525,58.1,5.07,44.99,"cell organization and biogenesis;other metabolic processes;transport;signal transduction","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","STAM2","ENSG00000115145","Endocytosis; JAK-STAT signaling pathway","Ub-specific processing proteases; Endosomal Sorting Complex Required For Transport (ESCRT); RHOU GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell","EGF/EGFR signaling pathway",1104.1,1116.5,1141.8,1165.2,1212,1007.9,0.9932941419751263,-0.009707091805758626,0.909789976946758,0.04105885205287913,0.940678305489299,0.026558871830205107,7069]
["O75907","Diacylglycerol O-acyltransferase 1 [OS=Homo sapiens]",9,3,6,3,488,55.2,9.32,23.89,"cell organization and biogenesis;other metabolic processes;other biological processes","plasma membrane;other membranes;ER/Golgi","other molecular function","DGAT1","ENSG00000185000; ENSG00000285482","Glycerolipid metabolism; Retinol metabolism; Metabolic pathways; Fat digestion and absorption","Neutrophil degranulation; Acyl chain remodeling of DAG and TAG; Triglyceride biosynthesis","Triacylglyceride synthesis; Statin inhibition of cholesterol production; Glycerolipids and glycerophospholipids; Congenital generalized lipodystrophy (CGL); Vitamin A and carotenoid metabolism",471.9,469.3,500.7,416.8,415.5,494.6,1.086668173939257,0.11991146483935297,0.2431231635142734,0.6141736618592843,0.4841926981269276,0.3149817642274007,3670]
["O75909","Cyclin-K [OS=Homo sapiens]",12,5,9,5,580,64.2,8.41,32.68,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","CCNK","ENSG00000090061","","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; RNA polymerase II transcribes snRNA genes","Male infertility",645.2,650.9,666.6,628.6,647.2,576.7,1.0594871794871792,0.08336613022808607,0.17096707961826774,0.7670875066635499,0.42230428689757316,0.3743745099402099,2959]
["O75915","PRA1 family protein 3 [OS=Homo sapiens]",28,6,74,6,188,21.6,9.77,239.08,"other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi","","ARL6IP5","ENSG00000144746","","Glutamate Neurotransmitter Release Cycle","",6410.8,6636.7,6835.8,6170.4,6535.6,8579.9,0.934106615177183,-0.09834087213736979,0.57158468264389,0.24291941797128558,0.6983805492216971,0.15590786478261193,5982]
["O75925","E3 SUMO-protein ligase PIAS1 [OS=Homo sapiens]",4,2,4,1,651,71.8,7.3,11.56,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PIAS1","ENSG00000033800","Ubiquitin mediated proteolysis; JAK-STAT signaling pathway; Hepatitis C","SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of transcription cofactors; SUMOylation of intracellular receptors; Regulation of IFNG signaling; SUMOylation of transcription factors; Formation of Incision Complex in GG-NER","Androgen receptor signaling pathway; Interleukin-11 signaling pathway; Mesodermal commitment pathway; TGF-beta signaling pathway; Immune response to tuberculosis; Interferon type I signaling pathways",367.1,411.6,388,470.5,467,382.3,0.8839975753902107,-0.17788568225856968,0.18128582132984936,0.7416361614809042,0.43020067146099644,0.3663289160973754,3080]
["O75928-1","E3 SUMO-protein ligase PIAS2 [OS=Homo sapiens]",4,2,4,1,621,68.2,7.52,10.58,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PIAS2","ENSG00000078043; ENSPTRG00000009998","Ubiquitin mediated proteolysis; JAK-STAT signaling pathway","Activation of anterior HOX genes in hindbrain development during early embryogenesis","Androgen receptor signaling pathway; TGF-beta signaling pathway",71.5,65.7,77.7,65.8,72.4,40.1,1.2052720134604598,0.26935877980278844,0.307630693111024,0.5119703360235608,0.531679530846175,0.27435005928648826,4229]
["O75934","Pre-mRNA-splicing factor spf27 [OS=Homo sapiens]",31,7,15,7,225,26.1,5.66,52.21,"RNA metabolism OR transcription;other metabolic processes","cytoskeleton;nucleus;other cell component","","BCAS2","ENSG00000116752","Spliceosome","mRNA Splicing - Major Pathway","",1273.7,1385.4,1169.8,1514.6,1671.1,2946.4,0.6244027331582982,-0.6794512425406424,0.168769240108423,0.7727067050355674,0.4208578560056171,0.37586456159002996,2931]
["O75935","Dynactin subunit 3 [OS=Homo sapiens]",45,7,19,7,186,21.1,5.47,63.76,"cell cycle OR cell proliferation;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","DCTN3","ENSG00000137100","Amyotrophic lateral sclerosis; Huntington disease; Pathways of neurodegeneration; Salmonella infection","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic","",2688.7,2748.2,2753.9,2600.6,2898.2,2779.9,0.9893823909551017,-0.015399872273606495,0.7584743343271053,0.12005911052484516,0.835144457607233,0.07823839671345736,6638]
["O75937","DnaJ homolog subfamily C member 8 [OS=Homo sapiens]",12,3,7,3,253,29.8,9.06,20.11,"","non-structural extracellular;cytosol;nucleus","other molecular function","DNAJC8","ENSG00000126698; ENSG00000285317","","mRNA Splicing - Major Pathway","mRNA processing",713.7,686.8,1172.5,947.1,826.4,502,1.130740496594155,0.17726787076561012,0.6556338294918693,0.18333864573210762,0.7588325668655698,0.11985403873948418,6315]
["O75940","Survival of motor neuron-related-splicing factor 30 [OS=Homo sapiens]",29,4,9,4,238,26.7,7.24,25.68,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","SMNDC1","ENSG00000119953","Spliceosome","mRNA Splicing - Major Pathway","",300.7,307.7,349.9,424.6,410.3,895.7,0.5537385877730266,-0.8527230340105312,0.18336128778657199,0.7366923495565189,0.4314834682653106,0.36503583906508563,3106]
["O75943-1","cell cycle checkpoint protein RAD17 [OS=Homo sapiens]",5,3,6,3,681,77,7.06,17.38,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","other molecular function","RAD17","ENSG00000152942; ENSG00000276618","","Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA)","miRNA regulation of DNA damage response; Gastric cancer network 2; DNA damage response",430.9,424.7,454.6,485,449.7,308.9,1.0535541974911546,0.07526453194404274,0.7049032072007315,0.1518705134548073,0.7945924647486345,0.09985555774731167,6484]
["O75947-1","ATP synthase subunit d, mitochondrial [OS=Homo sapiens]",41,6,30,6,161,18.5,5.3,46.16,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","ATP5PD","ENSG00000167863; ENSGGOG00000013716; ENSPTRG00000009628","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",2193.7,2248.7,1814.6,2101.4,2263.5,1748.1,1.023556355308359,0.03359053693449216,0.8258569986865046,0.08309514645433373,0.8836464358658559,0.053721469905166054,6831]
["O75955","Flotillin-1 [OS=Homo sapiens]",43,17,73,16,427,47.3,7.49,227.45,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","FLOT1","ENSG00000137312; ENSG00000206379; ENSG00000206480; ENSG00000230143; ENSG00000232280","Insulin signaling pathway","RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Regulation of necroptotic cell death; Synaptic adhesion-like molecules","Angiopoietin-like protein 8 regulatory pathway; Insulin signaling",5605.8,5651.1,5636.3,5138.6,4898,5841.8,1.0639107214832728,0.0893770915558202,0.29867920763526873,0.5247950094801382,0.5257818710515846,0.27919439243656674,4152]
["O75962-1","Triple functional domain protein [OS=Homo sapiens]",4,7,9,6,3097,346.7,6.37,31.13,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;other cell component","enzyme regulator activity;kinase activity;other molecular function","TRIO","ENSG00000038382","","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; G alpha (q) signalling events; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; DCC mediated attractive signaling","Microtubule cytoskeleton regulation; Cell migration and invasion through p75NTR; Neural crest cell migration during development; Neural crest cell migration in cancer",320.7,321.9,312,345.4,310.9,370.8,0.9294129101353326,-0.10560840994956867,0.24246567599002253,0.61534973245634,0.4839381829085403,0.31521011053804465,3662]
["O75962-3","Isoform 3 of Triple functional domain protein [OS=Homo sapiens]",4,2,2,1,596,66.2,7.08,5.3,"","","","TRIO","","","","",197.3,192,183,190.7,183.2,353.7,0.7865585486531061,-0.3463739361025174,0.4059259061335745,0.391553231186198,0.5809501562424704,0.23586112715776505,5107]
["O75964","ATP synthase subunit g, mitochondrial [OS=Homo sapiens]",30,3,27,3,103,11.4,9.64,83.87,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","ATP5MG","ENSG00000167283","Oxidative phosphorylation; Metabolic pathways; Thermogenesis","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",2994.2,3209.7,3274.8,2797.8,2748.8,1744.5,1.3000370314493013,0.37855271889015446,0.10813982848976017,0.9660143235527912,0.3468161502552247,0.4599006868491938,2279]
["O75976","Carboxypeptidase D [OS=Homo sapiens]",11,11,15,11,1380,152.8,6.05,44.86,"protein metabolism;other metabolic processes","non-structural extracellular;plasma membrane;other membranes","other molecular function","CPD","ENSG00000108582","","Golgi Associated Vesicle Biogenesis; RND3 GTPase cycle; RND1 GTPase cycle","",1133.4,1114.1,1129.4,1315.8,1350.9,1142,0.886627983301389,-0.17359919805862123,0.09066581066406744,1.0425564509681138,0.3250006915859092,0.4881157148622808,2039]
["O75995","SAM and SH3 domain-containing protein 3 [OS=Homo sapiens]",59,12,44,12,380,41.6,5.27,179.05,"other biological processes","nucleus;other cell component","","SASH3","ENSG00000122122","","","",2858.6,2754.6,3483.7,3914.9,3524.3,4284.5,0.7759410425036464,-0.3659810570612407,0.05039735943745501,1.2975922177565504,0.2462261364494376,0.6086658494010201,1496]
["O76003","glutaredoxin-3 [OS=Homo sapiens]",36,11,63,11,335,37.4,5.39,205.95,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","GLRX3","ENSG00000108010","","Iron uptake and transport","",9183.6,9031.4,8997.4,9436.3,9781.2,9935.1,0.9334467594657082,-0.09936035636222461,0.01499563381963432,1.824035173215402,0.1401574010072983,0.8533839643912772,782]
["O76021","Ribosomal L1 domain-containing protein 1 [OS=Homo sapiens]",44,21,75,21,490,54.9,10.13,204.17,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","RSL1D1","ENSG00000171490","","","Senescence and autophagy in cancer",9517.3,9181.2,9417.5,17856.3,17706.9,16358.4,0.5415087362484977,-0.8849434816323121,8.2802074029826158E-5,4.081958784852465,0.014074426955441846,1.8515692785480784,43]
["O76024","Wolframin [OS=Homo sapiens]",18,13,34,13,890,100.2,8.05,95.23,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","WFS1","ENSG00000109501","Protein processing in endoplasmic reticulum","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; XBP1(S) activates chaperone genes","CAMKK2 pathway",2909.7,3111.3,2980.2,2999.6,3124.4,3463.7,0.9388278732125536,-0.09106741967670935,0.26434761844762217,0.5778245978736423,0.5014577584307476,0.2997656450026702,3853]
["O76031","ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial [OS=Homo sapiens]",46,25,57,25,633,69.2,7.58,171.36,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","CLPX","ENSG00000166855","","","",6778.8,6492,6681.7,7453.4,7718.1,7069.6,0.8971004131989875,-0.15665861864310307,0.020853273851559568,1.6808257534455064,0.16730689196602513,0.7764861685345318,911]
["O76039-1","Cyclin-dependent kinase-like 5 [OS=Homo sapiens]",2,2,4,1,1030,115.5,9.54,11.44,"","","","CDKL5","","","","",227.8,229.2,238.9,219.9,161.5,103.8,1.4342539159109646,0.5203004569528359,0.1055103464676847,0.9767049508544331,0.34320210161651427,0.46445006138958894,2247]
["O76062","Delta(14)-sterol reductase [OS=Homo sapiens]",16,4,8,4,418,46.4,8.87,24.51,"other metabolic processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","other molecular function","TM7SF2","ENSG00000149809","Steroid biosynthesis; Metabolic pathways","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways",604.8,655.8,647.2,582.3,511.7,578,1.1410287081339712,0.19033509010291785,0.047277993701903706,1.3253409615405036,0.23668140819672204,0.6258358554409676,1460]
["O76071","Probable cytosolic iron-sulfur protein assembly protein Ciao1 [OS=Homo sapiens]",43,10,29,10,339,37.8,4.97,123.12,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;other cell component","","CIAO1","ENSG00000144021","","Cytosolic iron-sulfur cluster assembly","",3238.5,3153.2,3239,3328.8,3171.5,2221.2,1.1042481224559997,0.14306437937763944,0.4319304277193694,0.36458620061758285,0.5981393513074784,0.22319762461764073,5278]
["O76074","cGMP-specific 3',5'-cyclic phosphodiesterase [OS=Homo sapiens]",18,14,21,14,875,99.9,6.09,54.97,"other metabolic processes;signal transduction","cytosol","other molecular function","PDE5A","ENSG00000138735","Purine metabolism; Metabolic pathways; cGMP-PKG signaling pathway","cGMP effects; RHOBTB1 GTPase cycle","Phosphodiesterases in neuronal function",1198.6,1229,1167.3,1482,1500.7,1847,0.7443319460836078,-0.4259819383832032,0.026537105776350316,1.576146444467109,0.18560737427688465,0.7314047730302087,1045]
["O76075","DNA fragmentation factor subunit beta [OS=Homo sapiens]",12,3,6,3,338,39.1,9,17.17,"cell organization and biogenesis;DNA metabolism;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DFFB","ENSG00000169598","Apoptosis","Apoptosis induced DNA fragmentation","Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis",464.7,431.2,460.4,508.8,422.7,3393.7,0.3135808748728382,-1.6730905219377419,0.368102468709459,0.43403126991193086,0.560746340933188,0.25123355165976974,4798]
["O76080","AN1-type zinc finger protein 5 [OS=Homo sapiens]",8,1,1,1,213,23.1,8.51,4.43,"developmental processes;signal transduction;other biological processes","other cell component","nucleic acid binding activity;other molecular function","ZFAND5","ENSG00000107372","","","",71.5,71.1,71.2,108.3,110.2,108.1,0.6546233925290875,-0.6112629378412044,6.39963937850768E-7,6.193844497943732,4.677496421751263E-3,2.329986536059759,1]
["O76094","Signal recognition particle subunit SRP72 [OS=Homo sapiens]",38,21,73,21,671,74.6,9.26,247.63,"transport","cytosol;ER/Golgi;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","SRP72","ENSG00000174780","Protein export","SRP-dependent cotranslational protein targeting to membrane","",10324.3,9998,9998.4,10519.1,9201.6,8103.1,1.0897397192331744,0.12398359315621013,0.30425199627465255,0.5167665635721069,0.5285899312506384,0.2768811137051303,4207]
["O76095-1","Protein JTB [OS=Homo sapiens]",9,1,1,1,146,16.3,8.28,3.64,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion;other cell component","other molecular function","JTB","ENSG00000143543; ENSGGOG00000005608; ENSPPAG00000028370; ENSPTRG00000001369","","","",63.6,75,65.3,71.7,76.3,67.8,0.9448563484708061,-0.08183308947142066,0.41023484769591967,0.38696745094172474,0.5831206732418275,0.23424156136459356,5142]
["O77932","Decapping and exoribonuclease protein [OS=Homo sapiens]",5,2,3,2,396,44.9,7.69,7.27,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus","nucleic acid binding activity;other molecular function","DXO","ENSG00000204348; ENSG00000206346; ENSG00000224313; ENSG00000225682; ENSG00000234798; ENSG00000236765","","","",370.4,370.5,356.9,384.9,367.5,363.2,0.9840444603800647,-0.023204595053754138,0.5007555266415067,0.30037424887080194,0.6458482696705087,0.18986949962832497,5667]
["O94760-1","N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 [OS=Homo sapiens]",33,8,25,7,285,31.1,5.81,85.27,"other metabolic processes;signal transduction;other biological processes","cytosol","other molecular function","DDAH1","ENSG00000153904; ENSMFAG00000037521; ENSMMUG00000014573; ENSMNEG00000044101; ENSRBIG00000034663; ENSRROG00000009892","","eNOS activation","Mesodermal commitment pathway; Nitric oxide metabolism in cystic fibrosis",3063.3,3036.5,3034.4,2876.7,2912.8,2412.7,1.1136280510107044,0.1552674565869463,0.12637472944831527,0.8983397611673483,0.37006125702633663,0.4317263802937617,2496]
["O94761","ATP-dependent DNA helicase Q4 [OS=Homo sapiens]",7,6,8,6,1208,133,8.09,22.05,"","","","","","","","",446,447,442,461.1,447.4,518,0.935856992639327,-0.09564000500680342,0.2320192560412949,0.634475970085651,0.47502205669630937,0.3232862243138712,3570]
["O94762-1","ATP-dependent DNA helicase Q5 [OS=Homo sapiens]",6,5,7,5,991,108.8,8.56,19.38,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RECQL5","ENSG00000108469","","","",603,599,605,760.7,768.6,1122.2,0.6815010371487837,-0.5532122422761463,0.07755991971089865,1.1103626491695535,0.30347187000372494,0.5178815591796551,1868]
["O94763-1","Unconventional prefoldin RPB5 interactor 1 [OS=Homo sapiens]",10,5,6,5,535,59.8,5.05,19.81,"other biological processes","cytosol;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","URI1","ENSG00000105176","","","",701.6,702.8,698.4,787.8,830.6,502.8,0.9913256647180841,-0.012569013568869953,0.9553235317101436,0.01984952449856942,0.9705948975909702,0.01296199609708878,7194]
["O94766","Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 [OS=Homo sapiens]",18,4,7,4,335,37.1,8.27,23.83,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","enzyme regulator activity;other molecular function","B3GAT3","ENSG00000149541","Glycosaminoglycan biosynthesis; Glycosaminoglycan biosynthesis; Metabolic pathways","A tetrasaccharide linker sequence is required for GAG synthesis; Defective B3GAT3 causes JDSSDHD","Proteoglycan biosynthesis",574.7,552.6,549.4,565.6,560.6,748,0.8946217052609114,-0.1606503335352321,0.3492817154701377,0.45682414862593146,0.5537744161325893,0.25666711213160665,4610]
["O94768","Serine/threonine-protein kinase 17B [OS=Homo sapiens]",16,5,12,5,372,42.3,5.25,31.11,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus","kinase activity;other molecular function","STK17B","ENSG00000081320","","","",769.6,783.1,770.8,922.7,877.1,2321,0.5638468258590564,-0.8266248003252035,0.2748118306036241,0.5609645749047883,0.5092798351627505,0.293043519289989,3944]
["O94776","Metastasis-associated protein MTA2 [OS=Homo sapiens]",41,28,99,27,668,75,9.66,247.68,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MTA2","ENSG00000149480","","Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation","Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome",10840.9,10486.3,10438.4,11132,10996.7,10456,0.9748624354374905,-0.03672944291153309,0.3230166046136546,0.49077515226105334,0.5391478335513135,0.2682921355692059,4379]
["O94788-1","retinal dehydrogenase 2 [OS=Homo sapiens]",3,2,5,1,518,56.7,6.05,11.85,"cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;other cell component","other molecular function","ALDH1A2","ENSG00000128918","Retinol metabolism; Metabolic pathways","RA biosynthesis pathway","Ethanol effects on histone modifications; Tryptophan metabolism; 22q11.2 copy number variation syndrome; Vitamin A and carotenoid metabolism",783.6,784.2,734.9,778.3,781,1723.3,0.7014866264546397,-0.5115124951497927,0.35830242930802697,0.44575024728604024,0.5564879846605119,0.2545442082420698,4706]
["O94804","Serine/threonine-protein kinase 10 [OS=Homo sapiens]",35,32,105,30,968,112.1,6.95,298.67,"cell adhesion;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol","kinase activity;other molecular function","STK10","ENSG00000072786","Progesterone-mediated oocyte maturation","RHOA GTPase cycle; RHOB GTPase cycle; Neutrophil degranulation; RHOC GTPase cycle","",11398.4,11439.8,11293.5,11283,10993.2,8945.6,1.093200904496217,0.12855855863609464,0.25843554800194346,0.5876477490389382,0.497080373775317,0.3035733837717755,3800]
["O94806","Serine/threonine-protein kinase D3 [OS=Homo sapiens]",18,12,29,9,890,100.4,6.87,95.06,"protein metabolism;other metabolic processes;signal transduction","other membranes;cytosol;nucleus","kinase activity;other molecular function","PRKD3","ENSG00000115825","Rap1 signaling pathway; Aldosterone synthesis and secretion; Chemical carcinogenesis","Sphingolipid de novo biosynthesis","G protein signaling pathways; Hippo signaling regulation pathways",2310.8,2336.7,2272.8,2691.5,2633.2,3264.2,{"$f":"AVERAGE(S706:U706)/AVERAGE(V706:X706)","v":0.8057259951798252},{"$f":"LOG(Y706,2)","v":-0.3116387928633608},{"$f":"TTEST(S706:U706,V706:X706,2,2)","v":0.05131715335117712},{"$f":"-LOG10(AA706)","v":1.2897374426744364},{"$f":"AA706*7309/AE706","v":0.2479028908418728},{"$f":"-LOG10(AC706)","v":0.60571840881365},1513]
["O94811","Tubulin polymerization-promoting protein [OS=Homo sapiens]",24,4,5,4,219,23.7,9.44,10.69,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","TPPP","ENSG00000171368","","","Microtubule cytoskeleton regulation; Glial cell differentiation; Sudden infant death syndrome (SIDS) susceptibility pathways",493.6,494.7,517.3,435.5,410.6,309.8,1.3025348213513277,0.38132194134783026,0.04098589785893374,1.3873655465866486,0.22059346645872363,0.6564073546471586,1358]
["O94813","Slit homolog 2 protein [OS=Homo sapiens]",0,1,1,1,1529,169.8,7.06,1.9,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;other membranes;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","SLIT2","ENSG00000145147","Axon guidance","Regulation of expression of SLITs and ROBOs; Netrin-1 signaling; Inactivation of CDC42 and RAC1; Activation of RAC1; Regulation of commissural axon pathfinding by SLIT and ROBO; Role of ABL in ROBO-SLIT signaling; SLIT2:ROBO1 increases RHOA activity","Spinal cord injury; Robo4 and VEGF signaling pathways crosstalk; Genes controlling nephrogenesis; GDNF/RET signaling axis; Development of ureteric collection system",150.4,164.2,180.4,172.1,165.3,13.5,1.4106583072100316,0.49636857745216795,0.41192787537924913,0.38517881810970117,0.58405059964053,0.23354952584526353,5155]
["O94822","E3 ubiquitin-protein ligase listerin [OS=Homo sapiens]",20,28,49,28,1766,200.4,6.25,119.14,"protein metabolism;other metabolic processes","cytosol;other cell component","translation activity;other molecular function","LTN1","ENSG00000198862","","Antigen processing: Ubiquitination & Proteasome degradation","",4227.3,4095.1,4215.6,4862.3,4536.2,4651.4,0.8923906931721933,-0.16425262723128164,0.008480871825018017,2.0715595004163387,0.10687360718802875,0.9711295320953031,580]
["O94826","Mitochondrial import receptor subunit TOM70 [OS=Homo sapiens]",57,28,155,28,608,67.4,7.12,436.56,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","TOMM70","ENSG00000154174","","Mitochondrial protein import; Ub-specific processing proteases; DDX58/IFIH1-mediated induction of interferon-alpha/beta; PINK1-PRKN Mediated Mitophagy","Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation",20489.4,20124.2,19961.4,18930.9,19424.1,14765.8,1.14032544690592,0.1894456258204387,0.1697483377402707,0.7701944698531312,0.4214302311629207,0.37527431363461944,2944]
["O94829","Importin-13 [OS=Homo sapiens]",13,11,22,11,963,108.1,5.3,61.34,"transport","nucleus;other cell component","other molecular function","IPO13","ENSG00000117408","Nucleocytoplasmic transport","","",1648.1,1589.8,1614.1,1528.8,1463.9,2174.7,0.9389635019545614,-0.09085901429533999,0.6680368578270408,0.17519957538477374,0.7683212264135078,0.11445716839082772,6355]
["O94830","Phospholipase DDHD2 [OS=Homo sapiens]",5,3,3,3,711,81,5.39,2.46,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","DDHD2","ENSG00000085788","","Synthesis of PA","",83.4,74.7,79.1,85.4,77.2,94.5,0.9225982108129134,-0.1162256002876522,0.3011842266406508,0.5211677763700815,0.5266400747647169,0.2784860962611438,4180]
["O94832","Unconventional myosin-Id [OS=Homo sapiens]",39,37,92,37,1006,116.1,9.39,237.91,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","MYO1D","ENSG00000176658","Pathogenic Escherichia coli infection","","",11019.5,10860,11010.2,9151.4,8683.2,9277.3,1.2131093726371076,0.27870962815652756,5.1168649481776025E-4,3.2909960454150724,0.024767659540549734,1.6061150308242689,151]
["O94842","TOX high mobility group box family member 4 [OS=Homo sapiens]",11,5,6,4,621,66.2,5.06,17.83,"other biological processes","nucleus;other cell component","nucleic acid binding activity","TOX4","ENSG00000092203","","","",562.3,559.2,599,648.7,697,598.9,0.8847577908053071,-0.17664553441465294,0.0740194336987939,1.1306542418892416,0.296605285583599,0.527821113997666,1824]
["O94854","Uncharacterized protein KIAA0754 [OS=Homo sapiens]",2,1,1,1,1291,135.1,4.21,2.88,"","","","KIAA0754","","","","",11.8,17.5,16.5,17.9,16.3,5.2,1.16243654822335,0.21715196864056746,0.6504666037171598,0.18677499609497772,0.7551239527586914,0.1219817535620129,6296]
["O94855","Protein transport protein Sec24D [OS=Homo sapiens]",22,19,48,18,1032,112.9,7.25,143.74,"cell organization and biogenesis;transport;developmental processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","SEC24D","ENSG00000150961","Protein processing in endoplasmic reticulum; Pathogenic Escherichia coli infection","MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Sterol regulatory element-binding proteins (SREBP) signaling",3731.2,3821.6,3675.5,4096.1,3868.7,3572,0.9732594826988419,-0.039103598725082324,0.5496642090616274,0.2599025408459623,0.6828991507787582,0.16564342734943582,5883]
["O94864-1","STAGA complex 65 subunit gamma [OS=Homo sapiens]",17,3,4,3,414,46.2,5.12,5.49,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","SUPT7L","ENSG00000119760; ENSPTRG00000011777","","HATs acetylate histones","",339.2,378.5,371.9,410.9,490.8,375.1,0.8533834586466164,-0.22873394821027496,0.16067555386139126,0.7940501943674215,0.4124965307948397,0.38457969963040367,2847]
["O94868","F-BAR and double SH3 domains protein 2 [OS=Homo sapiens]",13,8,12,8,740,84.2,5.77,33.34,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","FCHSD2","ENSG00000137478","","","",771.1,728.7,756,1063.9,1058.2,1040.8,0.7132062347845332,-0.4876087799594929,2.8925265931053015E-5,4.538722639572134,0.008456590747602659,2.0728046863601985,25]
["O94874-1","E3 UFM1-protein ligase 1 [OS=Homo sapiens]",51,38,145,15,794,89.5,6.79,367.15,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","UFL1","ENSG00000014123","","Antigen processing: Ubiquitination & Proteasome degradation","",14756.9,15028.9,14982,13778.2,13336.4,12167.2,1.1396575513342055,0.1886003829765663,0.019977737168184833,1.6994537048500153,0.1635131925669238,0.7864472018545887,893]
["O94874-3","Isoform 3 of E3 UFM1-protein ligase 1 [OS=Homo sapiens]",52,23,71,1,509,57.5,6.3,196.23,"","","","UFL1","","","","",60.4,52.4,51.2,51.3,34.9,11.4,1.680327868852459,0.7487427619425597,0.1372335948208435,0.8625395602083953,0.38534012468134654,0.4141557664336581,2603]
["O94876","Transmembrane and coiled-coil domains protein 1 [OS=Homo sapiens]",11,5,7,5,653,72,6.55,21.85,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","TMCC1","ENSG00000172765","","","",175.8,180.5,170.7,177.2,164.3,316,0.8015209125475286,-0.31918793254245004,0.42171444155424065,0.3749815263744521,0.5900288769754871,0.22912673275749668,5224]
["O94880","PHD finger protein 14 [OS=Homo sapiens]",9,7,14,7,888,100,5.33,29.98,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","PHF14","ENSG00000106443","","","",1582.3,1621.2,1613.8,1787.5,1894.9,2230.1,0.8147653276955603,-0.2955435071044119,0.052550872899829834,1.2794200656979495,0.25038743808660774,0.6013874634269387,1534]
["O94886","CSC1-like protein 1 [OS=Homo sapiens]",18,10,23,10,807,92.1,7.27,71.54,"transport","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","transporter activity;nucleic acid binding activity","TMEM63A","ENSG00000196187","","Neutrophil degranulation","",1988.5,1970.7,1978.4,1983.4,1961.1,2328.4,0.9465478486824276,-0.07925265783103176,0.4008061567545019,0.39706561592332035,0.5781512136804133,0.23795855833001847,5067]
["O94887-1","FERM, RhoGEF and pleckstrin domain-containing protein 2 [OS=Homo sapiens]",11,7,7,7,1054,119.8,8.79,30.06,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity","FARP2","ENSG00000006607","Rap1 signaling pathway; Adherens junction","RAC1 GTPase cycle; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion","",546.3,577.9,561.6,500.7,469,1188.4,0.7811500857235529,-0.35632832868844977,0.5393826331393438,0.2681030409257164,0.6752907957546186,0.17050916969373903,5838]
["O94888","UBX domain-containing protein 7 [OS=Homo sapiens]",42,16,38,15,489,54.8,5.16,97.06,"","other membranes;cytosol;ER/Golgi;nucleus","other molecular function","UBXN7","ENSG00000163960","","Neddylation","3q29 copy number variation syndrome",3897.6,3739.6,3799.8,4127.1,4283.4,6674,0.758195498690709,-0.39935820344853445,0.21475515117426003,0.6680564102686591,0.46098249630915317,0.33631556463349016,3405]
["O94901-9","Isoform 9 of SUN domain-containing protein 1 [OS=Homo sapiens]",21,14,35,13,916,101.9,7.31,101.23,"","","","SUN1","","","","",1795.6,1882.4,1879.8,1782,1924.9,2456.9,0.9016840260878031,-0.14930613131634296,0.38503093500693675,0.4145043760419215,0.5705983584683091,0.24366948208164257,4932]
["O94903","Pyridoxal phosphate homeostasis protein [OS=Homo sapiens]",43,11,42,11,275,30.3,7.5,111.97,"","cytosol;other cell component","other molecular function","PLPBP","ENSG00000147471","","","",4481,4615.8,4539.3,4418.8,4563.5,4315.3,1.0254557213331728,0.036265198310017004,0.24025543296289628,0.6193267827265223,0.482027713292838,0.31692799208446526,3643]
["O94905-1","Erlin-2 [OS=Homo sapiens]",32,10,32,7,339,37.8,5.62,86.04,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","ERLIN2","ENSG00000147475; ENSGGOG00000012855; ENSPPAG00000034728; ENSPTRG00000020158","","ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Signaling by FGFR1 in disease; Signaling by plasma membrane FGFR1 fusions","",2910,3032.6,2844.1,2778.5,2740.5,2371.1,1.1136360755883956,0.1552778523171178,0.10169726017142831,0.9926907472587535,0.3392538907316155,0.4694751629354859,2191]
["O94906-1","Pre-mRNA-processing factor 6 [OS=Homo sapiens]",54,49,151,49,941,106.9,8.25,459.51,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PRPF6","ENSG00000101161; ENSGGOG00000016876; ENSPPAG00000008686; ENSPTRG00000013765","Spliceosome","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","mRNA processing; mRNA Processing",19268.1,19109.4,19228.9,18138.1,17969.8,17196.7,1.0807022283255105,0.1119690643336202,0.008152325429765819,2.0887184922093573,0.10453569573010241,0.9807353859978758,570]
["O94913","Pre-mRNA cleavage complex 2 protein Pcf11 [OS=Homo sapiens]",9,13,22,13,1555,172.9,8.48,58.17,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","PCF11","ENSG00000165494","mRNA surveillance pathway","RNA polymerase II transcribes snRNA genes; mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs","",2628.1,2656.7,2725.7,2663.5,2816.9,2522.7,1.0009246417013407,1.333359652108476E-3,0.9793920945841093,0.009043405823574411,0.9860023167100902,0.006122064639695142,7260]
["O94915-1","protein furry homolog-like [OS=Homo sapiens]",9,26,41,20,3013,339.4,5.58,118.14,"cell organization and biogenesis;developmental processes;other biological processes","other cell component","","FRYL","ENSG00000075539","","","",4046.1,3965,4061.1,3780.5,3708.1,3843.5,1.0653100484464486,0.0912733743551582,0.007418455985019421,2.1296864757133265,0.09948898127432466,1.0022250161059962,545]
["O94915-2","Isoform 2 of Protein furry homolog-like [OS=Homo sapiens]",19,7,12,1,403,45.6,4.5,39.26,"","","","FRYL","","","","",305.4,294.6,314.6,300.7,286.7,341.2,0.9849235408141289,-0.021916361759697897,0.8010653393570182,0.09633205899079489,0.8649706847925019,0.06299861120408046,6769]
["O94916","nuclear factor of activated T-cells 5 [OS=Homo sapiens]",2,2,2,2,1531,165.7,5.24,2.25,"RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NFAT5","ENSG00000102908","","","Cancer immunotherapy by PD-1 blockade",89.2,93,91.2,100.1,112.7,130.2,0.7970845481049562,-0.3271953334541148,0.057730055273680025,1.2385980266856278,0.2611070383634451,0.5831814212402222,1616]
["O94919","endonuclease domain-containing 1 protein [OS=Homo sapiens]",25,8,25,8,500,55,5.71,78.53,"other metabolic processes","non-structural extracellular;cytosol","nucleic acid binding activity;other molecular function","ENDOD1","ENSG00000149218","","Platelet degranulation","",1418.7,1447,1453.2,1378.2,1398.8,1541.6,1.000069466956884,1.0021615338677997E-4,0.9985704617484507,0.00062128475535838,0.999390867440699,2.6462351283552732E-4,7303]
["O94921-1","Cyclin-dependent kinase 14 [OS=Homo sapiens]",14,6,12,4,469,53,8.92,26.99,"cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","CDK14","ENSCATG00000032271; ENSCSAG00000012501; ENSG00000058091; ENSGGOG00000003585; ENSMLEG00000038830; ENSMNEG00000032203; ENSPANG00000022338","Transcriptional misregulation in cancer","","",621.4,569.7,629.7,673,615.8,607.9,0.9599831285917647,-0.05891904375240105,0.4143088042627506,0.3826758376355649,0.5853823797325428,0.23256035416067447,5173]
["O94923","D-glucuronyl C5-epimerase [OS=Homo sapiens]",5,2,2,2,617,70.1,8.97,5.72,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","GLCE","ENSG00000138604","Glycosaminoglycan biosynthesis; Metabolic pathways","HS-GAG biosynthesis","",166.3,167.3,166,154.5,191.8,246.1,0.8433490884537475,-0.2457981636808904,0.3094659896577173,0.5093870730270335,0.5328355520396363,0.27340680572303194,4245]
["O94925-1","Glutaminase kidney isoform, mitochondrial [OS=Homo sapiens]",49,24,114,5,669,73.4,7.77,364.69,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;mitochondrion;other cell component","other molecular function","GLS","ENSG00000115419; ENSGGOG00000007590; ENSPTRG00000012747","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; D-Amino acid metabolism; Metabolic pathways; Glutamatergic synapse; GABAergic synapse; Proximal tubule bicarbonate reclamation; MicroRNAs in cancer; Central carbon metabolism in cancer","Glutamate Neurotransmitter Release Cycle; TP53 Regulates Metabolic Genes; Glutamate and glutamine metabolism","Amino acid metabolism; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling",14294.9,13777.9,13940.3,12737.1,12722.9,9590.2,1.1986550718683489,0.2614165647594537,0.09323392933142395,1.0304260121108668,0.3288835856580008,0.48295780130008914,2072]
["O94925-3","Isoform 3 of Glutaminase kidney isoform, mitochondrial [OS=Homo sapiens]",50,22,119,3,598,65.4,7.88,372.88,"","","","GLS","","","","",2433.3,2533.6,2453.3,2522.8,2554.2,1950,1.05595559982923,0.07854917441903948,0.545643587185994,0.26309094458642507,0.6803324767557882,0.1672787968048688,5862]
["O94927","HAUS augmin-like complex subunit 5 [OS=Homo sapiens]",6,3,5,3,633,71.6,8.51,15.7,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","","HAUS5","ENSG00000249115","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",200.7,208,204.2,232.9,213,223.9,0.9150492684383398,-0.1280786712523322,0.0363827409525436,1.4391045857639013,0.20971723471777698,0.6783658774256424,1268]
["O94941-1","RING finger protein 37 [OS=Homo sapiens]",3,1,4,1,541,58.9,7.56,12.59,"protein metabolism;other metabolic processes","nucleus;other cell component","other molecular function","UBOX5","ENSG00000185019","Ubiquitin mediated proteolysis","Antigen processing: Ubiquitination & Proteasome degradation","",37,34.9,33.1,40.5,35.9,63.2,0.7521489971346704,-0.4109096136561674,0.24696737977632485,0.6073604059253378,0.48812454807602984,0.3114693508645191,3698]
["O94953","lysine-specific demethylase 4B [OS=Homo sapiens]",8,6,13,6,1096,121.8,7.09,46.78,"cell organization and biogenesis;protein metabolism;other metabolic processes","nucleus","other molecular function","KDM4B","ENSG00000127663","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Estrogen-dependent gene expression; HDMs demethylate histones","",426,399.6,432,454.6,461.1,446.6,0.9231446817881522,-0.11537131988688401,0.03192365930322832,1.4958873327313034,0.20114657400628946,0.6964873600742488,1160]
["O94964-2","Isoform 2 of Protein SOGA1 [OS=Homo sapiens]",3,5,5,3,1661,183.7,6.52,15.95,"","","","SOGA1","","","","",207.9,230.2,221.6,290.8,299.1,1118.2,0.3862186054680639,-1.3725104293819088,0.2719455532924432,0.5655180381407509,0.5074419323498768,0.2946136478046437,3917]
["O94966-5","Isoform 5 of Ubiquitin carboxyl-terminal hydrolase 19 [OS=Homo sapiens]",14,12,20,12,1419,155.9,6.38,58.78,"","","","USP19","","","","",881,845.6,873.5,926.5,885.7,838.2,0.9810217325686688,-0.02764299807408683,0.5775713371682631,0.23839436740955972,0.7022906177612437,0.15348313349420342,6011]
["O94973","AP-2 complex subunit alpha-2 [OS=Homo sapiens]",37,28,67,18,939,103.9,6.96,194.09,"transport","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","AP2A2","ENSG00000183020","Endocytosis; Synaptic vesicle cycle; Endocrine and other factor-regulated calcium reabsorption; Huntington disease","Neutrophil degranulation; MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; Recycling pathway of L1; Potential therapeutics for SARS; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation","Synaptic vesicle pathway; GABA receptor signaling; mBDNF and proBDNF regulation of GABA neurotransmission",3331,3415,3306.3,3156.2,3140.9,3008.8,1.0802071803909346,0.11130804336732812,0.012160392697334392,1.915052400101802,0.12697187174973867,0.8962924782320861,700]
["O94979","Protein transport protein Sec31A [OS=Homo sapiens]",41,39,144,39,1220,132.9,6.89,421.07,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","SEC31A","ENSG00000138674","Protein processing in endoplasmic reticulum","Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Signaling by ALK fusions and activated point mutants; MHC class II antigen presentation; COPII-mediated vesicle transport; XBP1(S) activates chaperone genes","Sterol regulatory element-binding proteins (SREBP) signaling",18557.8,18030.2,18147.5,17881,16696.8,16012.8,1.08193024000506,0.11360748101014405,0.07201118032110096,1.1426000705852788,0.29224304106992055,0.5342558215208391,1801]
["O94986-1","Isoform 1 of Centrosomal protein of 152 kDa [OS=Homo sapiens]",6,6,6,6,1275,147.3,5.43,14.01,"","","","CEP152","","","","",381.9,388.9,374.1,434.1,455.4,1351.4,0.5109107947699586,-0.968856676870317,0.29341838206027077,0.5325126819812502,0.5229443927038574,0.2815444893847619,4101]
["O94992","Protein HEXIM1 [OS=Homo sapiens]",4,2,2,2,359,40.6,4.89,2.06,"stress response;developmental processes;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","HEXIM1","ENSG00000186834","","","Initiation of transcription and translation elongation at the HIV-1 LTR",158.3,148.8,255.3,271.4,191,152,0.9153645833333336,-0.1275816216486205,0.7410059743133617,0.1301782905350218,0.822727125361744,0.08474418374312766,6583]
["O95067","G2/mitotic-specific cyclin-B2 [OS=Homo sapiens]",12,3,3,3,398,45.3,8.9,12.41,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity","CCNB2","ENSG00000157456","FoxO signaling pathway; Cell cycle; Oocyte meiosis; p53 signaling pathway; Cellular senescence; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection; Human immunodeficiency virus 1 infection","Resolution of Sister Chromatid Cohesion; Initiation of Nuclear Envelope (NE) Reformation; The role of GTSE1 in G2/M progression after G2 checkpoint; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; Cyclin A/B1/B2 associated events during G2/M transition; Golgi Cisternae Pericentriolar Stack Reorganization; Polo-like kinase mediated events; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint","miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; TGF-beta signaling pathway; IL-18 signaling pathway; DNA damage response",415.7,408.2,394.7,364.3,327.7,299.4,1.2291708694775065,0.29768548154698243,0.018591924235952316,1.7306756590818717,0.15727821092659197,0.8033314396767921,864]
["O95070","protein YIF1A [OS=Homo sapiens]",2,1,3,1,293,32,8.95,3.54,"transport","other membranes;ER/Golgi;other cell component","","YIF1A","ENSG00000174851","","XBP1(S) activates chaperone genes","",210.9,242.5,233.4,215.1,237.3,832.4,0.534557907845579,-0.9035818535151806,0.3804261843269981,0.4197295986816074,0.5681518147212973,0.2455356018134049,4894]
["O95071","E3 ubiquitin-protein ligase UBR5 [OS=Homo sapiens]",17,37,75,37,2799,309.2,5.85,229.82,"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","UBR5","ENSG00000104517","Ubiquitin mediated proteolysis","","Mesodermal commitment pathway",7428.4,7080.3,7279.5,7174.1,7110.2,7044.9,1.0215197944601768,0.030717160109170385,0.22780045578380298,0.6424454113184086,0.4719369419852086,0.32611602589421773,3528]
["O95081","Arf-GAP domain and FG repeat-containing protein 2 [OS=Homo sapiens]",2,1,1,1,481,48.9,9.11,3.14,"","","enzyme regulator activity;other molecular function","AGFG2","ENSG00000106351","","","",74.5,80.9,86.5,55.8,67.2,77.5,1.206483790523691,0.2708085326376425,0.12626861460274524,0.8987045845096153,0.37019546896568994,0.43156890112941576,2493]
["O95104","Splicing factor, arginine/serine-rich 15 [OS=Homo sapiens]",16,15,30,14,1147,125.8,9.55,88.37,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","SCAF4","ENSG00000156304","","","",2341.7,2258.3,2342.4,2597.2,2561.5,2973,0.853745219326832,-0.2281225000471901,0.04212038393251188,1.3755076788205634,0.22389664448198496,0.6499524151028718,1375]
["O95136","Sphingosine 1-phosphate receptor 2 [OS=Homo sapiens]",3,1,1,1,353,38.8,8.97,2.94,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","S1PR2","ENSG00000267534","Sphingolipid signaling pathway; Neuroactive ligand-receptor interaction","G alpha (i) signalling events; Lysosphingolipid and LPA receptors","Small ligand GPCRs; S1P receptor signal transduction; Sphingolipid metabolism in senescence",32.2,32.9,45.2,42.9,34.1,57.1,0.8225205070842655,-0.28187644631309133,0.373137886958285,0.42813065216113083,0.5636009125393894,0.2490283123857818,4839]
["O95139","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [OS=Homo sapiens]",31,4,13,4,128,15.5,9.63,34.02,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB6","ENSG00000165264","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",1157.4,1127.1,1010.7,1164.8,1474.7,1949.2,0.7181118835400003,-0.47771945800709525,0.13719130874804134,0.8626734008911165,0.3853694372173075,0.41412273123271104,2602]
["O95140","Mitofusin-2 [OS=Homo sapiens]",18,12,18,12,757,86.3,6.98,52.88,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion","other molecular function","MFN2","ENSG00000116688","Mitophagy; NOD-like receptor signaling pathway; Parkinson disease; Pathways of neurodegeneration","Factors involved in megakaryocyte development and platelet production; PINK1-PRKN Mediated Mitophagy; RHOT2 GTPase cycle","Intracellular trafficking proteins involved in CMT neuropathy",1194.2,1107.6,1103.2,1250.4,1203.6,3013.7,0.6227481390712731,-0.6832792895519725,0.31321226657857465,0.5041612376643283,0.534002439100257,0.27245675929098806,4287]
["O95149","Snurportin-1 [OS=Homo sapiens]",5,2,5,2,360,41.1,6.64,11.37,"transport","cytosol;nucleus","nucleic acid binding activity;other molecular function","SNUPN","ENSG00000169371","Nucleocytoplasmic transport","snRNP Assembly","",558.7,525.6,534,648.7,679.4,706.4,0.795428852297862,-0.33019520144915476,0.002024636094980609,2.6936530248661605,0.05102781109728715,1.2921930608811436,290]
["O95155","Ubiquitin conjugation factor E4 B [OS=Homo sapiens]",21,21,35,20,1302,146.1,6.55,90.04,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","other molecular function","UBE4B","ENSG00000130939","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum","","",2666.5,2627.5,2690.5,2872.2,2844,2285.2,0.9978878696228161,-3.0503825589095423E-3,0.9780009854866027,0.009660707593607222,0.9852803863434293,0.006440162483388935,7255]
["O95159","Zinc finger protein-like 1 [OS=Homo sapiens]",12,3,9,3,310,34.1,8.07,41.08,"transport;other biological processes","other membranes;ER/Golgi;nucleus","nucleic acid binding activity;other molecular function","ZFPL1","ENSG00000162300","","","",935.4,887.4,858.8,1088.1,1111.3,1463.7,0.732057546886517,-0.44997103197296734,0.057105389470411494,1.243322902142844,0.25988996988744556,0.5852104812015333,1606]
["O95163","Elongator complex protein 1 [OS=Homo sapiens]",21,22,60,22,1332,150.2,5.94,211.47,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","ELP1","ENSG00000070061","","HATs acetylate histones","",5692.3,5569.3,5622.3,5656.9,5616.5,4565.4,1.0659835341061195,0.09218515343769466,0.38687987904216636,0.41242385660129044,0.5715999668322608,0.2429078050814987,4947]
["O95166","Gamma-aminobutyric acid receptor-associated protein [OS=Homo sapiens]",6,1,1,1,117,13.9,8.79,2.91,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","GABARAP","ENSG00000170296","FoxO signaling pathway; Autophagy; Mitophagy; Autophagy; NOD-like receptor signaling pathway; GABAergic synapse","Macroautophagy; TBC/RABGAPs","Senescence and autophagy in cancer",136.1,138.7,107.6,233.3,245.6,81.6,0.6822479928635146,-0.5516318497120408,0.3307036179473364,0.48056105381333347,0.541710610393788,0.26623265787717937,4462]
["O95167","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [OS=Homo sapiens]",49,3,11,3,84,9.3,8.46,20.56,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity","NDUFA3","ENSG00000170906; ENSG00000273642; ENSG00000274359; ENSG00000275605; ENSG00000275724; ENSG00000276061; ENSG00000276220; ENSG00000276766; ENSG00000277722; ENSG00000278365","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",1018.7,1107.6,1081.9,1248.2,1493.8,758,0.9166285714285715,-0.12559083948727906,0.678408382111177,0.16850879476941186,0.7758546181897344,0.11021965043399469,6391]
["O95168-1","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [OS=Homo sapiens]",14,1,1,1,129,15.2,9.85,5.37,"cell organization and biogenesis;other metabolic processes;stress response;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB4","ENSG00000065518; ENSGGOG00000013923; ENSPPAG00000027750; ENSPTRG00000015270","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",50,55,53.3,54.2,68,286,0.38780009799118087,-1.3666149268955379,0.32946702599600014,0.4821880443311981,0.5407757675734931,0.2669827775784481,4453]
["O95169","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [OS=Homo sapiens]",28,4,7,4,186,21.8,6.8,13.42,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;ER/Golgi","transporter activity","NDUFB8","ENSG00000166136","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Mitochondrial protein import; Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",668.5,737.8,721.7,726.9,834.8,1961.3,0.6040306556911723,-0.727306323993774,0.30465993019087556,0.5161846617646323,0.5285448444730856,0.27691815900750705,4213]
["O95182","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [OS=Homo sapiens]",5,1,1,1,113,12.5,10.18,0,"protein metabolism;other metabolic processes;transport","other membranes;mitochondrion;translational apparatus","transporter activity;other molecular function","NDUFA7","ENSG00000267855","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",86.3,95.5,102.4,103.3,107.3,181.8,0.7242609582059125,-0.465418486976458,0.23690521543834986,0.6254253782339102,0.47912014931900915,0.3195555645748503,3614]
["O95183","vesicle-associated membrane protein 5 [OS=Homo sapiens]",16,2,2,1,116,12.8,7.85,5.66,"transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","VAMP5","ENSG00000168899","SNARE interactions in vesicular transport","","",58.5,47.9,51.6,38.7,38,81.8,0.9968454258675078,-0.004558281962304463,0.9915622768602504,3.680003952488708E-3,0.9941465955516557,2.549570386490378E-3,7290]
["O95197","Reticulon-3 [OS=Homo sapiens]",3,4,20,4,1032,112.5,4.96,41.5,"cell organization and biogenesis;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","","RTN3","ENSG00000133318","Alzheimer disease","Synaptic adhesion-like molecules","Alzheimer's disease and miRNA effects; Alzheimer's disease",3889.6,3799.2,3777.9,3711.6,3401.7,5506,0.9086637135181824,-0.13818162731566744,0.5899865780193372,0.22915786828741927,0.7100628846934521,0.14870318752600983,6073]
["O95202-1","mitochondrial proton/calcium exchanger protein [OS=Homo sapiens]",48,34,143,34,739,83.3,6.7,456.4,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity;translation activity;other molecular function","LETM1","ENSG00000168924","","RHOG GTPase cycle; Mitochondrial calcium ion transport","",14018.5,14465.7,14369.5,12055.3,13086.7,8128.8,1.2880273392885049,0.3651632159970561,0.10290724497621961,0.9875540485375548,0.3398775659878848,0.4686775005808398,2213]
["O95208-1","epsin-2 [OS=Homo sapiens]",7,5,7,4,641,68.4,7.52,20.07,"transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","EPN2","ENSG00000072134","Endocytosis","Cargo recognition for clathrin-mediated endocytosis","",503.1,486.6,501.3,578.9,661.9,950,0.6805733065546832,-0.5551775278577327,0.10696494996489594,0.9707585076468026,0.345168573639481,0.46196875211168026,2265]
["O95210","Starch-binding domain-containing protein 1 [OS=Homo sapiens]",39,15,34,15,358,39,5.73,84.87,"other metabolic processes;transport","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","STBD1","ENSG00000118804","","Neutrophil degranulation; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle","Exercise-induced circadian regulation",4334.6,4519.7,4556.3,4578.3,4673.6,5107.1,0.9339508322306566,-0.09858149352215813,0.1479345585266409,0.8299303599839524,0.39987192613580563,0.39807908536957765,2704]
["O95218-1","Zinc finger Ran-binding domain-containing protein 2 [OS=Homo sapiens]",35,13,50,13,330,37.4,10.01,133.31,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","ZRANB2","ENSANAG00000018241; ENSCANG00000036472; ENSCATG00000025001; ENSG00000132485; ENSGGOG00000023501; ENSMFAG00000003326; ENSMLEG00000036639; ENSMNEG00000042080; ENSNLEG00000009455; ENSPANG00000013398; ENSPPAG00000037049; ENSPTRG00000000856; ENSSBOG00000013268","","","",7987,8060.3,7963.7,7434.9,8154.6,6001,{"$f":"AVERAGE(S770:U770)/AVERAGE(V770:X770)","v":1.1121094926009125},{"$f":"LOG(Y770,2)","v":0.15329883541385844},{"$f":"TTEST(S770:U770,V770:X770,2,2)","v":0.27187460603384805},{"$f":"-LOG10(AA770)","v":0.5656313550252408},{"$f":"AA770*7309/AE770","v":0.5075687089403309},{"$f":"-LOG10(AC770)","v":0.29450515953523},3915]
["O95219","sorting nexin-4 [OS=Homo sapiens]",11,5,6,5,450,51.9,5.99,13.91,"transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","SNX4","ENSG00000114520","Endocytosis","","",400.6,364.5,335.5,334.1,334.5,251.1,1.1966945743177122,0.25905498825220613,0.14643878145503153,0.834343893622503,0.39788886752967484,0.4002382117409381,2690]
["O95229","ZW10 interactor [OS=Homo sapiens]",8,2,2,2,277,31.3,5.15,5.15,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","ZWINT","ENSG00000122952","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",197.4,235.4,166.6,325.7,411.9,405.6,0.5243177046885935,-0.9314868325822417,0.006048463146384361,2.218354961187758,0.08841643427384659,1.053467003639804,500]
["O95232-1","Luc7-like protein 3 [OS=Homo sapiens]",49,22,71,22,432,51.4,9.79,189.39,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity","LUC7L3","ENSCANG00000028098; ENSCATG00000034891; ENSG00000108848; ENSGGOG00000024399; ENSMLEG00000034172; ENSMMUG00000010117; ENSPPAG00000025115; ENSPTRG00000009409; ENSRROG00000039925","","","",7875,7332.7,7584.3,7671.2,8059.8,11482.6,0.8375224152629568,-0.25580029194486703,0.2938937845159858,0.5318095986124962,0.5230264599530898,0.2814763395821757,4107]
["O95235","kinesin-like protein KIF20A [OS=Homo sapiens]",19,14,24,14,890,100.2,6.92,75.44,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","KIF20A","ENSG00000112984","","COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Mitotic Telophase/Cytokinesis","",1622.5,1628,1547.4,1083.2,1061.5,1186.7,1.4402053190850697,0.5262745003553828,4.6539514300664685E-4,3.3321781534438286,0.02412463191656441,1.6175393042152355,141]
["O95236-1","Apolipoprotein L3 [OS=Homo sapiens]",24,10,18,10,402,44.3,8.16,43.95,"protein metabolism;other metabolic processes;stress response;transport","non-structural extracellular;other cell component","transporter activity;other molecular function","APOL3","ENSG00000128284","","","",1278.4,1305.5,1273.2,1437.7,1525.3,1517.7,0.8608253174727164,-0.21620758570191925,2.2086494542218633E-3,2.655873207703872,0.053810062869692,1.2691365005395614,300]
["O95239-1","Chromosome-associated kinesin KIF4A [OS=Homo sapiens]",32,33,76,33,1232,139.8,6.27,222.16,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","KIF4A","ENSG00000090889; ENSGGOG00000006631; ENSPTRG00000021996","","MHC class II antigen presentation; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","Retinoblastoma gene in cancer",6979,6845.1,6855.5,5325.5,5550,5923.6,1.230994517563441,0.29982433655701785,1.9723808614408524E-3,2.7050092202003984,0.05058291830270593,1.2959961183249358,285]
["O95243","Methyl-CpG-binding domain protein 4 [OS=Homo sapiens]",24,11,15,1,580,66,8.82,29.4,"DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus","nucleic acid binding activity;other molecular function","MBD4","ENSG00000129071","Base excision repair","Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Displacement of DNA glycosylase by APEX1","Base excision repair; DNA repair pathways, full network",1759.7,1812.9,1770.4,2233.3,2174.8,2735.7,0.7479212743917802,-0.4190416737341768,0.02835843945081301,1.547317671815772,0.19068245993191563,0.7196892540180937,1087]
["O95243-2","Isoform 2 of Methyl-CpG-binding domain protein 4 [OS=Homo sapiens]",24,11,15,1,574,65.3,8.84,29.64,"","","","MBD4","","","","",170.2,172.7,187.4,164.8,192.8,122.9,1.1036420395421436,0.1422723174796331,0.47362661508858733,0.324563900750225,0.6283784588278245,0.2017787112395734,5509]
["O95248-1","Myotubularin-related protein 5 [OS=Homo sapiens]",26,36,70,36,1867,208.2,6.9,212.66,"","","","","","","","",5754.5,5592.3,5641.1,5126.6,5074.6,8227.3,0.9218276039829614,-0.11743112528932739,0.6692741702891358,0.1743959356678886,0.7690182220788073,0.11406336936044807,6361]
["O95249-1","Golgi SNAP receptor complex member 1 [OS=Homo sapiens]",24,7,11,7,250,28.6,9.42,33.73,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","GOSR1","ENSG00000108587","SNARE interactions in vesicular transport","Intra-Golgi traffic; COPI-mediated anterograde transport","",1680.6,1669.6,1621.9,1982.7,1958.6,1478.4,0.9174124029005295,-0.12435768290881152,0.4175598983723259,0.37928121678712207,0.5866869083435852,0.23159360276300303,5202]
["O95251-1","Histone acetyltransferase KAT7 [OS=Homo sapiens]",9,7,13,7,611,70.6,8.85,30.93,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","KAT7","ENSAMEG00000012243; ENSANAG00000032052; ENSCANG00000040077; ENSCATG00000030056; ENSCJAG00000007037; ENSDLEG00000005028; ENSECAG00000010150; ENSG00000136504; ENSGGOG00000007469; ENSMLEG00000043692; ENSMNEG00000044419; ENSPANG00000022824; ENSPCTG00005022544; ENSPPAG00000041097; ENSPPYG00000008925; ENSPTRG00000009383; ENSRFEG00010021504","","HATs acetylate histones","Androgen receptor signaling pathway; Androgen receptor signaling pathway",1431.6,1422.4,1384.9,1739,1705.1,1827.9,0.8040402124430955,-0.3146604382076882,9.3526710433917981E-4,3.029064340598673,0.03435109178701038,1.4640594551244066,199]
["O95260","Arginyl-tRNA--protein transferase 1 [OS=Homo sapiens]",22,8,18,8,518,59.1,7.93,49.56,"protein metabolism;other metabolic processes","nucleus;other cell component","other molecular function","ATE1","ENSG00000107669","","","",863.6,897.2,915.3,944.3,990.5,965.2,0.922793103448276,-0.11592087289740607,0.020913907189815253,1.6795648235926703,0.16705983349766085,0.7771279557751456,915]
["O95263-4","Isoform 4 of High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [OS=Homo sapiens]",1,1,2,1,865,96.7,6.83,1.82,"","","","PDE8B","","","","",143.2,170.9,152.9,138.1,132.6,46.3,1.473186119873817,0.5589397095702546,0.17998216527712962,0.7447705277048846,0.4300391127854006,0.36649204280559033,3059]
["O95271","Tankyrase-1 [OS=Homo sapiens]",1,1,1,1,1327,142,7.05,0,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","TNKS","ENSG00000173273","","Degradation of AXIN; Ub-specific processing proteases; Regulation of PTEN stability and activity; XAV939 stabilizes AXIN","NAD+ biosynthetic pathways; Regulation of Wnt / B-catenin signaling by small molecule compounds",76.9,49,40.3,44,56,77.3,0.937394247038917,-0.09327215412834418,0.8139226063220625,0.08941688902385982,0.8754908505677638,0.057748388208399955,6795]
["O95273-1","Cyclin-D1-binding protein 1 [OS=Homo sapiens]",8,3,8,3,360,40.2,4.82,20.1,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","","CCNDBP1","ENSG00000166946","","","",599.7,578.3,571.5,509.4,526,410.2,1.2102241283895958,0.27527425326261196,0.05256680561464959,1.2792884134339586,0.2501372280191887,0.6018216672454789,1536]
["O95292","Vesicle-associated membrane protein-associated protein B/C [OS=Homo sapiens]",44,10,36,9,243,27.2,7.3,130.67,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","VAPB","ENSG00000124164","Cholesterol metabolism; Amyotrophic lateral sclerosis; Pathways of neurodegeneration","RHOA GTPase cycle; Sphingolipid de novo biosynthesis; RHOC GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOD GTPase cycle","Ciliary landscape",4831.8,5202.3,5132.9,5028,5651.5,3906.3,1.0398469744546066,0.05637123467497738,0.7298953449274833,0.1367394061518943,0.8147228277451093,0.08899011500782518,6548]
["O95295","SNARE-associated protein Snapin [OS=Homo sapiens]",14,2,4,2,136,14.9,9.31,12.19,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SNAPIN","ENSG00000143553","","Golgi Associated Vesicle Biogenesis","",142.4,160,135.6,138.7,204.6,292,0.6894380607586967,-0.5365071493122524,0.21760445484371418,0.6623322179157752,0.46355900916721277,0.33389497408797564,3431]
["O95297-1","Myelin protein zero-like protein 1 [OS=Homo sapiens]",3,1,2,1,269,29.1,8.72,4.69,"cell-cell signaling;signal transduction","plasma membrane;other membranes","other molecular function","MPZL1","ENSG00000197965","Cell adhesion molecules","","",389.6,406.8,398.7,391.6,390,223.7,1.1887993633741174,0.24950524839724772,0.3211519482672343,0.49328943899584765,0.5382480141906021,0.2690175637853011,4361]
["O95298-1","NADH dehydrogenase [ubiquinone] 1 subunit C2 [OS=Homo sapiens]",30,5,22,5,119,14.2,8.98,49.67,"cell organization and biogenesis;other metabolic processes;transport","plasma membrane;other membranes;mitochondrion;other cytoplasmic organelle;other cell component","transporter activity","NDUFC2","ENSG00000151366; ENSGGOG00000041901","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Neutrophil degranulation; Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",2729.8,3074.1,2894.1,2414.3,3329.6,2422.1,1.065148175361254,0.09105414123891735,0.6086223776823345,0.2156520836484241,0.7222635100633517,0.14130432585470543,6159]
["O95299","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [OS=Homo sapiens]",35,10,24,10,355,40.7,8.48,57.68,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;other cell component","transporter activity","NDUFA10","ENSG00000130414","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",2481.9,2365.3,2412,2313.7,2151,1836.9,1.1519614066268886,0.20409238396714607,0.0909135951678977,1.0413711677690867,0.32541012100008043,0.48756894363600517,2042]
["O95319-1","CUGBP Elav-like family member 2 [OS=Homo sapiens]",17,9,36,8,508,54.3,8.76,79.13,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","CELF2","ENSANAG00000024646; ENSCATG00000032144; ENSG00000048740; ENSPANG00000023401; ENSPPYG00000002083; ENSSBOG00000028844","","","mRNA processing",4606.1,4641.5,4647.7,4932.1,4745.6,3931.1,1.0210525542296158,0.03005712456553428,0.7717157047182259,0.11254266159653427,0.844002706237545,0.07365616083625459,6683]
["O95336","6-phosphogluconolactonase [OS=Homo sapiens]",38,6,21,6,258,27.5,6.05,60.85,"other metabolic processes","cytosol;other cell component","other molecular function","PGLS","ENSG00000130313","Pentose phosphate pathway; Metabolic pathways; Carbon metabolism","Pentose phosphate pathway","Pentose phosphate metabolism",1346.2,1420.1,1466.8,1278.8,1449.5,1581.1,0.982294518958556,-0.025772445768910836,0.8007063204468893,0.09652674333699944,0.8648385541815152,0.0630649579364955,6767]
["O95340","bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [OS=Homo sapiens]",29,15,34,13,614,69.5,8.03,114.36,"other metabolic processes;developmental processes","cytosol","kinase activity;other molecular function","PAPSS2","ENSG00000198682","Purine metabolism; Selenocompound metabolism; Sulfur metabolism; Metabolic pathways","Transport and synthesis of PAPS; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se; Defective PAPSS2 causes SEMD-PA","RANKL/RANK signaling pathway; Proteoglycan biosynthesis; Sulfation biotransformation reaction",3261.6,3145.7,3183.5,3110.3,3173.4,3454.9,0.9848232805536729,-0.02206322833068459,0.6808746733177979,0.16693282009231872,0.7780664457910859,0.10898331328254285,6396]
["O95347-1","structural maintenance of chromosomes protein 2 [OS=Homo sapiens]",48,65,205,65,1197,135.6,8.43,553.65,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMC2; SMC2L1","ENSG00000136824","","Condensation of Prophase Chromosomes; Condensation of Prometaphase Chromosomes","Retinoblastoma gene in cancer",25471.4,24779.9,24699.6,25197.5,25235.8,21413.2,1.0432087853966443,0.061027924408239516,0.4678274302451459,0.3299143176810897,0.6251098149290258,0.2040436821305475,5470]
["O95352","Ubiquitin-like modifier-activating enzyme ATG7 [OS=Homo sapiens]",6,3,3,3,703,77.9,6.24,2.83,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;cytosol;cytoskeleton;other cell component","other molecular function","ATG7","ENSG00000197548","Autophagy; Autophagy; Ferroptosis; Neutrophil extracellular trap formation","Neutrophil degranulation; Antigen processing: Ubiquitination & Proteasome degradation; Signaling by BRAF and RAF1 fusions; Macroautophagy","Nanoparticle triggered autophagic cell death; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Senescence and autophagy in cancer",62.1,65.2,55.2,55.8,66.6,49.9,1.0591990713871156,0.08297376242979383,0.5838096111301527,0.23372875959392486,0.7052999087190556,0.1516261723624208,6050]
["O95359","Transforming acidic coiled-coil-containing protein 2 [OS=Homo sapiens]",1,4,12,1,2948,309.2,4.79,28.04,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","TACC2","ENSG00000138162","","","",77.3,68.2,65.6,62.6,57,34,1.3743489583333333,0.4587483626259997,0.11222520468833802,0.9499095938128354,0.35432139138965985,0.4506026272828343,2315]
["O95363","phenylalanine--tRNA ligase, mitochondrial [OS=Homo sapiens]",7,3,6,3,451,52.3,7.46,19.74,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","FARS2","ENSG00000145982","Aminoacyl-tRNA biosynthesis","Mitochondrial tRNA aminoacylation","",991.1,995.3,936.5,986,922.1,1049,0.9884346149944203,-0.01678256013492014,0.7959086985522288,0.09913674883163089,0.8610563466131202,0.06496842784662897,6756]
["O95365","Zinc finger and BTB domain-containing protein 7A [OS=Homo sapiens]",11,3,4,3,584,61.4,5.19,20.38,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB7A","ENSG00000178951","","","IL-18 signaling pathway",90.7,83.2,82.3,110.5,105,441.6,0.38989499315172726,-1.3588424664445882,0.29622172381704104,0.5283830950791207,0.5244875434541553,0.28026482181430273,4128]
["O95372","acyl-protein thioesterase 2 [OS=Homo sapiens]",29,5,22,5,231,24.7,7.23,67.04,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes","cytosol;ER/Golgi;other cell component","other molecular function","LYPLA2","ENSG00000011009","Glycerophospholipid metabolism","L1CAM interactions","",2584.8,2889.6,2851.1,2578.5,2839.4,3622.7,0.9209012676149814,-0.11888160562580204,0.5077204587801467,0.29437533618903905,0.6511543837908567,0.18631603127889668,5699]
["O95373","Importin-7 [OS=Homo sapiens]",36,27,146,26,1038,119.4,4.82,481.3,"stress response;transport;signal transduction;other biological processes","cytosol;nucleus","transporter activity;enzyme regulator activity;other molecular function","IPO7","ENSG00000205339","Nucleocytoplasmic transport","","",14225.9,13937.5,14156.1,13352.1,12832.8,13001.7,1.079948247615256,0.11096217840933385,0.004034190662947423,2.394243580117004,0.07389949763278876,1.1313585139197793,399]
["O95376","E3 ubiquitin-protein ligase ARIH2 [OS=Homo sapiens]",25,9,23,9,493,57.8,5.63,62.16,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","other molecular function","ARIH2","ENSG00000177479","","Antigen processing: Ubiquitination & Proteasome degradation","Modulators of TCR signaling and T cell activation",1283.7,1294.3,1298.1,1311.3,1263.7,1596.6,0.929163869977946,-0.1059950380469801,0.397353430057793,0.4008230336883799,0.5763556698337784,0.23930943016017564,5039]
["O95379","Tumor necrosis factor alpha-induced protein 8 [OS=Homo sapiens]",24,4,10,4,198,23,7.93,27.88,"other biological processes","nucleus;other cell component","enzyme regulator activity","TNFAIP8","ENSG00000145779","","PI Metabolism","",202.8,196,194.8,246.4,301.5,73.8,0.9548013511339876,-0.066727486916642,0.898037404593902,0.046705573944701505,0.9311612129630912,0.030975122628603392,7049]
["O95391","Pre-mRNA-splicing factor SLU7 [OS=Homo sapiens]",16,8,13,8,586,68.3,7.14,34.85,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SLU7","ENSG00000164609","Spliceosome","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway","",671.2,613.1,691.9,971.9,921.8,1091.9,0.66191050375134,-0.5952919300037129,0.003789063008758519,2.4214681727327627,0.07174679153112958,1.1441975155205448,386]
["O95394","phosphoacetylglucosamine mutase [OS=Homo sapiens]",23,14,33,14,542,59.8,6.25,91.25,"protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol","other molecular function","PGM3","ENSG00000013375","Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars","Synthesis of UDP-N-acetyl-glucosamine","Glucuronidation",5427.1,5082.9,5240.9,5312,4315.6,2833,1.2640563054748566,0.3380607276132387,0.20591067961989984,0.6863211279826922,0.45372359280731017,0.3432086376182016,3317]
["O95396","Adenylyltransferase and sulfurtransferase MOCS3 [OS=Homo sapiens]",14,6,11,6,460,49.6,6.21,33.72,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;other cell component","other molecular function","MOCS3","ENSG00000124217","Sulfur relay system","Molybdenum cofactor biosynthesis","",1066.1,1050,1036.3,1097.1,1073.9,956,1.0081228014070995,0.01167138704238535,0.858444301059477,0.0662878781702267,0.9046091978725083,0.04353900075440763,6936]
["O95400","CD2 antigen cytoplasmic tail-binding protein 2 [OS=Homo sapiens]",50,10,33,10,341,37.6,4.61,102.7,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","CD2BP2","ENSG00000169217","","mRNA Splicing - Major Pathway","mRNA processing; Ciliary landscape",1896.4,1979.6,2080.6,2214,2251.9,2548.7,0.849171727539703,-0.23587175616558217,0.0408594414332003,1.3887075746623814,0.22039974718469446,0.6567889079888329,1355]
["O95425","Supervillin [OS=Homo sapiens]",1,2,2,2,2214,247.6,6.98,2.04,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","SVIL","ENSG00000197321","","","",253.1,283.7,250.9,238.3,246.5,64,1.4353134110787173,0.5213657942107864,0.25810129708171986,0.5882098129144107,0.49682970249415076,0.30379244817023493,3797]
["O95427","GPI ethanolamine phosphate transferase 1 [OS=Homo sapiens]",2,2,2,2,931,105.7,8.65,5.83,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;ER/Golgi","other molecular function","PIGN","ENSG00000197563","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways","Synthesis of glycosylphosphatidylinositol (GPI)","",198.3,203,221.5,227.5,234.3,316.6,0.8001027749229187,-0.3217427657020748,0.1535044692981686,0.8138789754748973,0.4053338750362407,0.3921870993756446,2768]
["O95433","activator of 90 kDa heat shock protein ATPase homolog 1 [OS=Homo sapiens]",71,19,101,19,338,38.3,5.53,313.06,"other biological processes","cytosol;ER/Golgi","other molecular function","AHSA1","ENSG00000100591","","","T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection",12476,11920.7,12140.9,12479.5,11762.3,13363.3,0.9716128929320756,-0.04154646077427162,0.5082144824303915,0.2939529631542332,0.6513308174791743,0.1861983728553658,5703]
["O95453","poly(A)-specific ribonuclease PARN [OS=Homo sapiens]",26,16,30,16,639,73.4,6.2,64.2,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PARN","ENSG00000140694; ENSG00000274829","RNA degradation","Deadenylation of mRNA; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA","Lung fibrosis",2338.6,2238.3,2341.5,2446.3,2346.3,2285.3,0.9774650673222283,-0.03288295062749918,0.4105085834913589,0.38667775760919404,0.583169530950115,0.2342051748236728,5145]
["O95456","Proteasome assembly chaperone 1 [OS=Homo sapiens]",48,9,19,9,288,32.8,7.17,59.26,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes","cytosol;ER/Golgi;nucleus;other cell component","other molecular function","PSMG1","ENSG00000183527","","","",1617.5,1568.4,1569.3,1557.1,1473.4,791.7,1.2441002563968395,0.31510275040297236,0.2696777436474561,0.5691548941475653,0.5060525361538528,0.2958043942721756,3895]
["O95461-1","LARGE xylosyl- and glucuronyltransferase 1 [OS=Homo sapiens]",5,4,6,3,756,88,7.84,7.11,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","LARGE; LARGE1","ENSG00000133424; ENSPTRG00000014294","Mannose type O-glycan biosynthesis; Metabolic pathways","Defective LARGE causes MDDGA6 and MDDGB6; O-linked glycosylation","",122.7,126,124,115.9,116.4,174,0.9173024858478956,-0.12453054550223812,0.5929687867950717,0.2269681668034196,0.7116599117709654,0.14772749755232195,6090]
["O95466-2","Isoform 2 of Formin-like protein 1 [OS=Homo sapiens]",42,47,196,5,1104,122.3,5.83,583.57,"","","","FMNL1","","","","",23412.7,22808.8,23033.3,21633.8,22308.1,22747.6,1.0384663252835904,0.05445443415650623,0.08122709057862348,1.0902991022042636,0.30905195473147273,0.5099685051819843,1921]
["O95470","sphingosine-1-phosphate lyase 1 [OS=Homo sapiens]",5,3,8,3,568,63.5,9.16,14.54,"other metabolic processes;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","SGPL1","ENSG00000166224","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway","Sphingolipid de novo biosynthesis","Sphingolipid pathway; Kennedy pathway from sphingolipids; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway",609.8,623.2,598.3,597.9,558.2,338.6,1.225195691443099,0.29301219863732747,0.238022688246873,0.6233816441586328,0.4800518290277027,0.31871187127943534,3624]
["O95476","CTD nuclear envelope phosphatase 1 [OS=Homo sapiens]",4,1,1,1,244,28.4,9.76,3.48,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","CTDNEP1","ENSG00000175826; ENSG00000288307","","Depolymerisation of the Nuclear Lamina","Development of ureteric collection system",129.5,152.6,144.7,144.7,164.4,125,0.9831835982492513,-0.02446724642845592,0.863126774580115,0.06392541117121457,0.9075807215373415,0.0421147377968796,6951]
["O95478","Ribosome biogenesis protein NSA2 homolog [OS=Homo sapiens]",26,6,10,6,260,30,10.27,28.21,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","NSA2","ENSG00000164346","","","",933.6,878.5,902.9,2118.4,1893.5,2250.7,0.43352601156069365,-1.2058095371408437,3.6041573562294011E-4,3.443196256136295,0.02270929837644887,1.6437962834792406,116]
["O95479","GDH/6PGL endoplasmic bifunctional protein [OS=Homo sapiens]",3,2,2,2,791,88.8,7.3,6.86,"other metabolic processes;other biological processes","mitochondrion;ER/Golgi","other molecular function","H6PD","ENSG00000049239","Pentose phosphate pathway; Metabolic pathways; Carbon metabolism","","Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism",101.6,103.2,101.9,78.6,87.6,236.5,0.7616091383163647,-0.3928773056787343,0.5658679324284988,0.2472849167095855,0.6945304312543907,0.1583087206444089,5955]
["O95486-1","Protein transport protein Sec24A [OS=Homo sapiens]",9,9,26,9,1093,119.7,7.66,77.11,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi","other molecular function","SEC24A","ENSG00000113615","Protein processing in endoplasmic reticulum; Pathogenic Escherichia coli infection","MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Sterol regulatory element-binding proteins (SREBP) signaling",2125.6,1985.9,2148,2292.8,2132.7,2255.6,0.9368966188202542,-0.0940382313613049,0.11543169767675585,0.93767491703961,0.3582548952524027,0.44580786662055205,2355]
["O95487-1","Protein transport protein Sec24B [OS=Homo sapiens]",13,13,27,13,1268,137.3,6.67,85.07,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","SEC24B","ENSG00000138802","Protein processing in endoplasmic reticulum; Pathogenic Escherichia coli infection","COPII-mediated vesicle transport; MHC class II antigen presentation; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Sterol regulatory element-binding proteins (SREBP) signaling",2164.4,2135.5,2110.8,2329.4,2196.8,2879.7,0.8656206538030489,-0.2081931724512042,0.18872456117761932,0.7241715757769052,0.4373455350815535,0.3591753028858162,3154]
["O95503","Chromobox protein homolog 6 [OS=Homo sapiens]",2,1,1,1,412,43.9,10.01,2.47,"cell organization and biogenesis;other biological processes","nucleus;other cell component","","CBX6","ENSG00000183741","","Regulation of PTEN gene transcription; Oxidative Stress Induced Senescence; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","",63.3,70.5,76.7,250.5,265.5,195.1,0.2960202503164112,-1.7562322229798901,1.5536047493266995E-3,2.8086594598078354,0.0445305769130543,1.3513416783578176,255]
["O95544","NAD kinase [OS=Homo sapiens]",7,2,3,2,446,49.2,6.47,11.27,"other metabolic processes;other biological processes","cytosol","kinase activity;other molecular function","NADK","ENSG00000008130","Nicotinate and nicotinamide metabolism; Metabolic pathways; Biosynthesis of cofactors","Nicotinate metabolism","NAD+ metabolism",212.7,211.6,507.8,266,220.1,432.5,1.0146962769431744,0.02104795862205293,0.9713572693631793,0.012621005338950952,0.981428017939657,0.00814154788057888,7234]
["O95551-1","Tyrosyl-DNA phosphodiesterase 2 [OS=Homo sapiens]",21,5,10,5,362,40.9,5.1,40.15,"DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TDP2","ENSG00000111802","","Nonhomologous End-Joining (NHEJ)","Oxidative damage response",750.1,822.1,774.9,1262.3,1310.1,1721.3,0.5466380976779933,-0.8713420835887298,0.011621017489738273,1.9347558451958522,0.12417838718201323,0.9059539850319953,684]
["O95562","Vesicle transport protein SFT2B [OS=Homo sapiens]",17,2,2,2,160,17.8,9.13,7.37,"transport","other membranes","","SFT2D2","ENSG00000213064","","","TYROBP causal network in microglia",170.5,216.1,199.1,210.4,178.2,136.5,1.115406589221101,0.15756969878127866,0.467571028352261,0.33015240644207683,0.6249957290099992,0.2041229504538885,5468]
["O95563","Mitochondrial pyruvate carrier 2 [OS=Homo sapiens]",28,4,16,4,127,14.3,10.43,39.48,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MPC2","ENSG00000143158","Diabetic cardiomyopathy","Pyruvate metabolism","Glycolysis and gluconeogenesis",2245.7,2513.5,2596,1886.3,2199,1261.4,1.3756522714945665,0.46011584097824165,0.08592393637242653,1.0658858351633294,0.31670098383563566,0.49935058748465894,1983]
["O95568","histidine protein methyltransferase 1 homolog [OS=Homo sapiens]",8,2,3,2,372,42.1,6.76,10.13,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","METTL18","ENSG00000171806","","","",120.7,143,119.4,151.2,167,193.2,0.7491200625733281,-0.4167311348177689,0.04153026247961552,1.3816353240529342,0.22205171065362825,0.6535458767367835,1367]
["O95571","Persulfide dioxygenase ETHE1, mitochondrial [OS=Homo sapiens]",20,4,16,4,254,27.9,6.83,64.11,"other metabolic processes","mitochondrion;nucleus;other cell component","other molecular function","ETHE1","ENSG00000105755","Sulfur metabolism; Metabolic pathways","Sulfide oxidation to sulfate","",2407.8,2377.7,2464.5,2091.7,2255.7,2730.3,1.0243440665752999,0.03470038307971393,0.7810144722059434,0.10734091856706658,0.8492167178448736,0.07098146481655226,6722]
["O95573","long-chain-fatty-acid--CoA ligase 3 [OS=Homo sapiens]",27,15,45,12,720,80.4,8.38,138.07,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ACSL3","ENSG00000123983","Fatty acid biosynthesis; Fatty acid degradation; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; Peroxisome; Ferroptosis; Thermogenesis; Adipocytokine signaling pathway","Synthesis of very long-chain fatty acyl-CoAs; Intracellular metabolism of fatty acids regulates insulin secretion","Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Ciliary landscape; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters",4292.9,4251.1,4341.7,3863.6,3917.7,4242.2,1.071709568761176,0.0999139911712044,0.07652304394558775,1.1162077628674432,0.3005410683494362,0.5220961741142373,1861]
["O95602","DNA-directed RNA polymerase I subunit RPA1 [OS=Homo sapiens]",21,29,61,28,1720,194.7,7.03,192.23,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POLR1A","ENSG00000068654","RNA polymerase","B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","Pyrimidine metabolism; Eukaryotic transcription initiation",4282.1,4265.6,4358.6,4977.8,4693.8,5136.2,0.8715879468928538,-0.1982818491886386,0.008763056672635465,2.0573443796187507,0.10892717894607587,0.9628637438109162,588]
["O95613","Pericentrin [OS=Homo sapiens]",23,67,104,67,3336,377.8,5.55,318.42,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton","other molecular function","PCNT","ENSG00000160299","","Late endosomal microautophagy; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Chaperone Mediated Autophagy","",9274.2,9115.1,9072.6,10737.7,10715.2,9884,0.8763438629858091,-0.19043102405297407,0.010884729571964106,1.9631823564127515,0.11981398861669525,0.9214924738967961,664]
["O95619","YEATS domain-containing protein 4 [OS=Homo sapiens]",22,5,8,5,227,26.5,8.41,21.32,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","other membranes;nucleus","cytoskeletal activity;other molecular function","YEATS4","ENSG00000127337","","HATs acetylate histones; Activation of the TFAP2 (AP-2) family of transcription factors","",851.9,794.1,759.2,1176.8,1013.7,851.9,0.7905600841440966,-0.3390529804345238,0.0951645336315328,1.0215248763840667,0.3309027480080272,0.4802996261923171,2102]
["O95620","tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like [OS=Homo sapiens]",7,1,1,1,317,35.8,7.33,4.6,"RNA metabolism OR transcription;other metabolic processes","","other molecular function","DUS4L","ENSG00000105865; ENSG00000284103","","","",10.8,12.5,12.3,11.4,11.8,26.7,0.7134268537074148,-0.4871625743708629,0.3997830006071159,0.39817567669985754,0.5775872606122574,0.23838239422445193,5059]
["O95625","Zinc finger and BTB domain-containing protein 11 [OS=Homo sapiens]",3,3,4,3,1053,119.3,8.66,12.07,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZBTB11","ENSG00000066422","","","",427.1,404,419.9,469.2,517.3,587.7,0.7946893660271884,-0.33153705545739365,0.03725230180809716,1.4288468871661597,0.21123124430983872,0.6752418426355898,1289]
["O95628-6","Isoform 6 of CCR4-NOT transcription complex subunit 4 [OS=Homo sapiens]",14,7,14,7,767,84.7,7.3,39.71,"","","","CNOT4","","","","",874.1,922.2,909.8,1032.5,979.5,1323.2,0.8113756296473975,-0.3015581242569724,0.12363472379665667,0.9078595370517193,0.3685343377772282,0.4335220410141237,2452]
["O95630","STAM-binding protein [OS=Homo sapiens]",21,10,22,10,424,48,6.29,53.17,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle","other molecular function","STAMBP","ENSG00000124356","Endocytosis","Metalloprotease DUBs","EGF/EGFR signaling pathway",3686.8,3506.7,3463.9,4026.2,3963,4309.2,{"$f":"AVERAGE(S834:U834)/AVERAGE(V834:X834)","v":0.8665680088466794},{"$f":"LOG(Y834,2)","v":-0.20661511737077604},{"$f":"TTEST(S834:U834,V834:X834,2,2)","v":0.012396087401737603},{"$f":"-LOG10(AA834)","v":1.9067153703192878},{"$f":"AA834*7309/AE834","v":0.1279703429651132},{"$f":"-LOG10(AC834)","v":0.8928906661250839},708]
["O95639","Cleavage and polyadenylation specificity factor subunit 4 [OS=Homo sapiens]",18,5,10,5,269,30.2,8.31,21.81,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CPSF4","ENSG00000160917","mRNA surveillance pathway; Influenza A","mRNA Splicing - Major Pathway; Transport of Mature mRNA Derived from an Intronless Transcript; tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Inhibition of Host mRNA Processing and RNA Silencing","mRNA processing",1140.2,1118.5,1071.1,1235.5,1197.8,788.6,1.0334895558521366,0.047523809376361414,0.815748477300522,0.08844372820585283,0.8766807264504507,0.05715854116805971,6801]
["O95671-1","N-acetylserotonin O-methyltransferase-like protein [OS=Homo sapiens]",24,12,24,12,621,68.8,6.07,76.91,"other metabolic processes","cytosol","other molecular function","ASMTL","ENSG00000169093","Pyrimidine metabolism","","",2606.2,2528.2,2517.6,2241,2038.3,2061.1,1.206863920257397,0.2712630144214299,0.00333703881330085,2.4766387420103695,0.06700663924839535,1.1738821637754524,364]
["O95674-1","phosphatidate cytidylyltransferase 2 [OS=Homo sapiens]",31,9,25,8,445,51.4,7.09,87.87,"cell organization and biogenesis;other metabolic processes","other membranes;mitochondrion;ER/Golgi","other molecular function","CDS2","ENSG00000101290","Glycerophospholipid metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of PG","",1853.3,2019.5,2019,1898.8,1987.2,2023.5,0.9970048227430409,-0.004327611597250731,0.9336344138855848,0.02982314851671838,0.9558669184885473,0.019602568591339672,7139]
["O95684","FGFR1 oncogene partner [OS=Homo sapiens]",34,7,10,7,399,43,4.81,32.64,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","CEP43","ENSG00000213066","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease","Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome",475.4,492.1,466.8,431.5,506.1,464.4,1.0230385164051354,0.03286046217086511,0.6617456110752546,0.1793089304076029,0.7633678458568555,0.11726613710506702,6336]
["O95696","Bromodomain-containing protein 1 [OS=Homo sapiens]",5,4,5,4,1058,119.4,8.6,10.81,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","other molecular function","BRD1","ENSG00000100425","","HATs acetylate histones; Regulation of TP53 Activity through Acetylation","Pathways affected in adenoid cystic carcinoma",367.2,396.9,406,396.5,423.5,528.8,0.867511862396204,-0.20504460958474216,0.22933673728963533,0.6395263703716476,0.4724414354143023,0.32565201964736346,3548]
["O95707","Ribonuclease P protein subunit p29 [OS=Homo sapiens]",12,2,3,2,220,25.4,10.07,9.23,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POP4","ENSG00000105171","Ribosome biogenesis in eukaryotes","tRNA processing in the nucleus","",154.7,156.5,156,164.1,156.1,164.4,0.9640940982253404,-0.0527541305713293,0.10441687547649388,0.9812293065631471,0.3423880407616392,0.4654814131594119,2229]
["O95714","E3 ubiquitin-protein ligase HERC2 [OS=Homo sapiens]",4,14,22,14,4834,526.9,6.28,62.99,"protein metabolism;DNA metabolism;other metabolic processes;stress response;transport","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","HERC2","ENSG00000128731","Ubiquitin mediated proteolysis","SUMOylation of DNA damage response and repair proteins; Antigen processing: Ubiquitination & Proteasome degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)","Prader-Willi and Angelman syndrome",1251.6,1243.9,1254.3,1443.4,1392.7,1602.6,0.8447968999932413,-0.24332355419263338,0.022216916871415367,1.6533162099601897,0.17129055423330686,0.7662665854142829,948]
["O95716","ras-related protein Rab-3D [OS=Homo sapiens]",31,7,25,4,219,24.3,4.93,56.46,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB3D","ENSG00000105514","Pancreatic secretion","Neutrophil degranulation; RAB geranylgeranylation","",974.9,1027.8,1054.5,1021.7,1067.2,958.1,1.0033475549721036,4.8214354422103055E-3,0.9352904559701938,0.029053497324230532,0.9571601711966041,0.019015381297020687,7142]
["O95721","Synaptosomal-associated protein 29 [OS=Homo sapiens]",22,6,7,6,258,29,5.81,17.87,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","SNAP29","ENSG00000099940","SNARE interactions in vesicular transport; Autophagy","Intra-Golgi traffic; Neutrophil degranulation","Ciliary landscape; 22q11.2 copy number variation syndrome",1170.7,1146.2,1016.5,1131.8,1162.4,1261.6,0.9374543000168739,-0.09317973265392199,0.29674020866050244,0.52762360226341,0.5248969470231394,0.2799259532270201,4132]
["O95747","Serine/threonine-protein kinase OSR1 [OS=Homo sapiens]",31,13,59,11,527,58,6.43,200.91,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol","kinase activity;other molecular function","OXSR1","ENSG00000172939","","","",4920.7,4735.2,4875.4,4489.1,4383.1,4095.8,1.1205505860579887,0.16420777924336732,0.01605041176178707,1.7945138216031502,0.14554895727903439,0.8369909015242679,806]
["O95749","geranylgeranyl pyrophosphate synthase [OS=Homo sapiens]",12,4,7,4,300,34.8,6.14,18.08,"other metabolic processes","cytosol","other molecular function","GGPS1","ENSG00000152904","Terpenoid backbone biosynthesis; Metabolic pathways","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways",1014.9,1067.8,1038.5,997.2,1042.3,557.9,1.2016632016632014,0.26503259873063656,0.3236779485265776,0.4898868871264419,0.5388979785377576,0.2684934454845903,4390]
["O95757","Heat shock 70 kDa protein 4L [OS=Homo sapiens]",56,41,192,36,839,94.5,5.88,590.57,"stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","HSPA4L","ENSG00000164070","Protein processing in endoplasmic reticulum","Regulation of HSF1-mediated heat shock response","",17884,17501.5,17840.9,18043.3,18086.7,13930.3,1.0632457256548604,0.08847505520921525,0.488099965056795,0.31149122343473395,0.6379689993920091,0.19520042428838594,5592]
["O95758-1","Isoform 1 of Polypyrimidine tract-binding protein 3 [OS=Homo sapiens]",17,8,57,3,521,56.5,9.22,133.39,"","","","PTBP3","","","","",1175.1,1100.8,1117.8,1111,1324.3,3166,0.6058772070769285,-0.7229026620665308,0.3226474579892202,0.49127175217657887,0.5389008844705692,0.2684911036179802,4376]
["O95772-1","STARD3 N-terminal-like protein [OS=Homo sapiens]",7,2,3,2,234,26.6,4.81,4.26,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","STARD3NL","ENSCANG00000042172; ENSCATG00000036966; ENSCSAG00000015104; ENSG00000010270; ENSGGOG00000013471; ENSMFAG00000043802; ENSMLEG00000030425; ENSMMUG00000023659; ENSMNEG00000034363; ENSPANG00000016262; ENSPPAG00000039214; ENSPTRG00000019094; ENSRBIG00000036179; ENSRROG00000026971","","Pregnenolone biosynthesis","",541.3,552.8,547.9,562,544.8,501.1,1.0212077865538902,0.030276443229639276,0.5707790104754407,0.24353200577865658,0.6975127549849516,0.1564478463067907,5981]
["O95777","U6 snRNA-associated Sm-like protein LSm8 [OS=Homo sapiens]",59,4,23,4,96,10.4,4.48,78.7,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","LSM8","ENSG00000128534","RNA degradation; Spliceosome","mRNA Splicing - Major Pathway","",979.1,981.1,974.1,949.3,944.4,574.8,1.1886975896293295,0.24938173322150595,0.2788730304109093,0.5545934839772922,0.513162885013428,0.2897447619166628,3972]
["O95782","AP-2 complex subunit alpha-1 [OS=Homo sapiens]",38,32,95,22,977,107.5,7.03,261.06,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","AP2A1","ENSG00000196961","Endocytosis; Synaptic vesicle cycle; Endocrine and other factor-regulated calcium reabsorption; Huntington disease","MHC class II antigen presentation; Recycling pathway of L1; Potential therapeutics for SARS; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Trafficking of GluR2-containing AMPA receptors; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation","Synaptic vesicle pathway; VEGFA-VEGFR2 signaling pathway; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; mBDNF and proBDNF regulation of GABA neurotransmission",11007.8,11265.7,11370.3,10116.4,10056.4,11456.9,1.0636774929891843,0.08906079200981369,0.2261003887970076,0.6456986908512355,0.4697463734273248,0.32813656408870506,3518]
["O95785-3","Isoform 3 of Protein Wiz [OS=Homo sapiens]",14,8,13,8,965,102.9,9.52,28.55,"","","","WIZ","","","","",390.3,419.6,401.7,553.4,560.3,717.5,0.661642638706859,-0.5958758847603141,0.019000840357743905,1.7212271909071601,0.1590803461337345,0.7983834727287568,873]
["O95793","double-stranded RNA-binding protein Staufen homolog 1 [OS=Homo sapiens]",12,6,9,6,577,63.1,9.44,22.2,"cell organization and biogenesis;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","nucleic acid binding activity;other molecular function","STAU1","ENSG00000124214","","","",755.2,722.9,732.3,764.5,765.9,685.8,0.9973829076798122,-3.7806153822936427E-3,0.9485481930526753,0.022940598939643897,0.9661285873776483,0.014965067091706608,7176]
["O95801","Tetratricopeptide repeat protein 4 [OS=Homo sapiens]",36,10,23,10,387,44.7,5.6,68.81,"stress response","nucleus;other cell component","other molecular function","TTC4","ENSG00000243725","","","",2548,2514.5,2496.4,3270.8,3444.9,2597.3,0.8116503811875871,-0.3010696752910922,0.08682722209698578,1.061344093336978,0.3181053465197338,0.4974290314757721,1995]
["O95816","BAG family molecular chaperone regulator 2 [OS=Homo sapiens]",33,8,15,8,211,23.8,6.7,43.88,"protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","BAG2","ENSG00000112208","Protein processing in endoplasmic reticulum","Regulation of HSF1-mediated heat shock response","Malignant pleural mesothelioma",1737.1,1748,1574,1806.5,1986.7,1400.3,0.9741214980263792,-0.0378263701480923,0.8179908919752222,0.08725153200951295,0.8785739058702278,0.056221699664893446,6805]
["O95817","BAG family molecular chaperone regulator 3 [OS=Homo sapiens]",4,2,3,2,575,61.6,6.95,7.24,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","BAG3","ENSG00000151929","","Regulation of HSF1-mediated heat shock response","",81.2,85.2,169,142.6,86.3,252.2,0.6971523591768863,-0.5204541105178754,0.43845107724811305,0.358078858549965,0.6019231637127082,0.22045894346862954,5324]
["O95819","Mitogen-activated protein kinase kinase kinase kinase 4 [OS=Homo sapiens]",7,7,7,4,1239,142,7.46,21.82,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","other cell component","cytoskeletal activity;kinase activity;other molecular function","MAP4K4","ENSG00000071054","MAPK signaling pathway","Oxidative Stress Induced Senescence","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Insulin signaling; Malignant pleural mesothelioma",223.2,253.2,244.8,234.4,248,323.2,0.8952333664349554,-0.15966428657444287,0.3872715562867738,0.4119843992218383,0.5713701665119156,0.24308243958768347,4954]
["O95822","Malonyl-CoA decarboxylase, mitochondrial [OS=Homo sapiens]",18,6,6,6,493,55,8.95,22.43,"other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","MLYCD","ENSG00000103150","beta-Alanine metabolism; Propanoate metabolism; Metabolic pathways; Peroxisome; AMPK signaling pathway; Alcoholic liver disease","","",478.5,499.9,485.2,450,466.9,891.2,0.8094685028482937,-0.30495314983651717,0.47119555423075454,0.3267988158061831,0.6272023867915835,0.20259229763158698,5491]
["O95825-1","Quinone oxidoreductase-like protein 1 [OS=Homo sapiens]",11,2,3,2,349,38.7,5.78,10.21,"other metabolic processes","","other molecular function","CRYZL1","ENSG00000205758","","","",238.1,255,256.1,236.9,234,141.4,1.2235832108443574,0.29111221648917013,0.22577758107901916,0.6463191841871894,0.46947605692931754,0.3283865516590591,3515]
["O95831-1","Apoptosis-inducing factor 1, mitochondrial [OS=Homo sapiens]",47,23,87,23,613,66.9,8.95,288.87,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","AIFM1","ENSG00000156709","Apoptosis; Necroptosis","","Apoptosis modulation and signaling; Nanomaterial induced apoptosis; Apoptosis modulation by HSP70",9673.9,9571.2,9897.2,9088.5,8936.1,7357.7,1.1481347238035955,0.19929193988758437,0.08943662920814141,1.0484845773455138,0.32328997175188207,0.4904077667165232,2022]
["O95834-3","Isoform 3 of Echinoderm microtubule-associated protein-like 2 [OS=Homo sapiens]",14,12,29,12,850,92,7.06,75.05,"","","","EML2","","","","",3401.1,3462.9,3484.7,3489,3410.4,3541.9,0.9911313725302408,-0.012851798387421832,0.5362321151607138,0.27064717950006906,0.6733070829255552,0.1717868169009767,5821]
["O95835","Serine/threonine-protein kinase LATS1 [OS=Homo sapiens]",1,1,1,1,1130,126.8,8.7,3.38,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","LATS1","ENSG00000131023","Hippo signaling pathway; Hippo signaling pathway","Signaling by Hippo","Mesodermal commitment pathway; Transcription co-factors SKI and SKIL protein partners; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Overview of leukocyte-intrinsic Hippo pathway functions; Malignant pleural mesothelioma",22.7,27.6,18.1,27.8,21.3,48.6,0.7001023541453428,-0.5143622370824875,0.32336622370731916,0.4903053450468116,0.5392388156689015,0.2682188538167979,4383]
["O95841","Angiopoietin-related protein 1 [OS=Homo sapiens]",2,1,1,1,491,56.7,8.21,0,"developmental processes;signal transduction","non-structural extracellular;extracellular matrix","signal transduction activity or receptor binding","ANGPTL1","ENSG00000116194","","","RAC1/PAK1/p38/MMP2 pathway",52.1,51,56.8,54.7,48.9,58,0.9894801980198018,-0.015257259271462958,0.8680339494847947,0.06146328889542062,0.9101219533473482,0.040900409747954766,6971]
["O95848","uridine diphosphate glucose pyrophosphatase [OS=Homo sapiens]",7,1,1,1,222,24.1,5.05,3.49,"protein metabolism;other metabolic processes","cytosol","other molecular function","NUDT14","ENSG00000183828","","Synthesis of dolichyl-phosphate-glucose","",40.3,31.7,36.9,42,36.2,57.5,0.8025055268975684,-0.31741676670194685,0.2611009040306714,0.5831916244817191,0.4986638378782799,0.3021921248222454,3827]
["O95861-1","3'(2'),5'-bisphosphate nucleotidase 1 [OS=Homo sapiens]",60,14,59,13,308,33.4,5.69,154.82,"other metabolic processes;developmental processes","cytosol","other molecular function","BPNT1; HEL20","ENSG00000162813; ENSPTRG00000001996","Sulfur metabolism; Metabolic pathways","Cytosolic sulfonation of small molecules","",6195,6274.9,6206.3,5863,5608.1,4592.2,1.1626627156312839,0.21743263674273267,0.08869707926213553,1.0520906809712296,0.32157090889233564,0.4927232468607442,2016]
["O95865","N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 [OS=Homo sapiens]",53,12,36,11,285,29.6,6.01,135.24,"other metabolic processes;signal transduction;other biological processes","cytosol;mitochondrion","other molecular function","DDAH2","ENSG00000206395; ENSG00000213722; ENSG00000225635; ENSG00000226634; ENSG00000227317; ENSG00000228128; ENSG00000233076","","eNOS activation","Nitric oxide metabolism in cystic fibrosis",3697.3,3612.2,3662.7,3466.9,3500.3,5286.7,0.895404728290585,-0.1593881583039707,0.5168257553096729,0.28665585199795357,0.6589010021905458,0.18117983188865594,5733]
["O95870-1","Protein ABHD16A [OS=Homo sapiens]",26,11,30,11,558,63.2,8.13,82.31,"other metabolic processes","other membranes","other molecular function","ABHD16A","ENSG00000204427; ENSG00000206403; ENSG00000224552; ENSG00000230475; ENSG00000231488; ENSG00000235676; ENSG00000236063; ENSGGOG00000009970","","","IL-18 signaling pathway",1797,1943.9,1893.5,1722.3,1820.7,2555.7,0.9238690212668274,-0.11423976247001326,0.5924941950923472,0.2273159002574557,0.7113239277151718,0.14793258213599916,6088]
["O95873","Uncharacterized protein C6orf47 [OS=Homo sapiens]",10,3,5,3,294,31.7,6.37,5.67,"","","","C6orf47","ENSG00000203623; ENSG00000204439; ENSG00000226103; ENSG00000226531; ENSG00000228177; ENSG00000228435; ENSG00000235360","","","",550.4,541.8,567.7,644.5,723.6,993.3,0.7029304649784027,-0.5085461122644652,0.09173153487355803,1.0374813397144689,0.3264195659156941,0.4862238170917554,2054]
["O95881","Thioredoxin domain-containing protein 12 [OS=Homo sapiens]",30,5,11,5,172,19.2,5.4,26.41,"other biological processes","ER/Golgi","other molecular function","TXNDC12","ENSG00000117862","Glutathione metabolism; Metabolic pathways","","",1631.8,1652.8,1570.6,1593.5,1638,1454.6,1.0360854441859966,0.051142984511283233,0.404138126621652,0.3934701760351585,0.5798676025672663,0.2366711547787818,5094]
["O95900","Mitochondrial mRNA pseudouridine synthase TRUB2 [OS=Homo sapiens]",12,4,9,3,331,36.7,8.98,19.47,"RNA metabolism OR transcription;other metabolic processes;other biological processes","mitochondrion;other cell component","other molecular function","TRUB2","ENSG00000167112","","","",243.3,255.7,247.4,292.1,270.8,240.2,0.9293985805005601,-0.10563065351017555,0.28962684925049076,0.5381611802482525,0.5212712733740056,0.28293620785431656,4061]
["O95905","Protein ecdysoneless homolog [OS=Homo sapiens]",15,6,10,6,644,72.7,4.87,14.3,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","ECD","ENSG00000122882","","","",505.1,475.2,509.6,683.1,740.1,818.3,0.6646888244479144,-0.5892489971210059,3.5175191877355903E-3,2.4537635248512952,0.0689264014561915,1.1616143947760098,373]
["O95983-1","methyl-CpG-binding domain protein 3 [OS=Homo sapiens]",6,2,3,2,291,32.8,5.34,7.15,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MBD3","ENSG00000071655; ENSPTRG00000010209","","Potential therapeutics for SARS; HDACs deacetylate histones; Regulation of PTEN gene transcription; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation","Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome",353.9,378.1,350.4,424.9,477.5,172.1,1.0073522568636575,0.010568261661391238,0.9791404886271162,0.009154990466356325,0.9858848093918712,0.006173824985681133,7259]
["O95985","DNA topoisomerase 3-beta-1 [OS=Homo sapiens]",14,8,10,8,862,96.6,8.12,22.94,"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TOP3B","ENSG00000100038","Homologous recombination; Fanconi anemia pathway","","",495.9,483.7,492.9,477.9,512.6,783.3,0.8301386853083775,-0.2685757175932281,0.35723378989560983,0.4470474689571755,0.5569585687600281,0.25417711008323685,4688]
["O95989","Diphosphoinositol polyphosphate phosphohydrolase 1 [OS=Homo sapiens]",33,5,11,5,172,19.5,6.34,27.02,"cell-cell signaling;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","NUDT3","ENSG00000272325","","Synthesis of pyrophosphates in the cytosol","",996.9,1023.5,1026.2,1091.1,987.9,1159,0.940889437924645,-0.08790289024296226,0.27598759084209123,0.5591104445650731,0.5104234062411045,0.29206941859669067,3952]
["O95997","Securin [OS=Homo sapiens]",11,2,2,2,202,22,6.6,5.51,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PTTG1","ENSG00000164611","Cell cycle; Oocyte meiosis; Human T-cell leukemia virus 1 infection","APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids","Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition",119.5,123.6,122.2,109.4,116.7,138.3,1.002469813391877,0.003558794559967468,0.9743198854870077,0.011298433579561772,0.9834696924491837,0.007239019176154466,7241]
["O95999","B-cell lymphoma/leukemia 10 [OS=Homo sapiens]",3,1,1,1,233,26.2,5.74,2.09,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","BCL10","ENSG00000142867","NF-kappa B signaling pathway; C-type lectin receptor signaling pathway; T cell receptor signaling pathway; B cell receptor signaling pathway; Shigellosis; Tuberculosis","E3 ubiquitin ligases ubiquitinate target proteins; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling","B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Modulators of TCR signaling and T cell activation; T-cell receptor (TCR) signaling pathway",49.8,56.1,64.5,71.9,47.3,372.4,0.3466232709519936,-1.5285595801468232,0.36387482442084174,0.4390479911115745,0.5593188415755904,0.2523405505010342,4755]
["O96000","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [OS=Homo sapiens]",26,4,6,4,172,20.8,8.48,9.51,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity","NDUFB10","ENSG00000140990","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Modulators of TCR signaling and T cell activation; Oxidative phosphorylation",286.7,290.4,239.6,345.3,311.7,298.7,0.8545568693104529,-0.22675159088281316,0.09688822342187843,1.0137290074044496,0.33278008693163036,0.4778426691434872,2128]
["O96005-1","Cleft lip and palate transmembrane protein 1 [OS=Homo sapiens]",33,14,54,14,669,76,6.3,171.56,"developmental processes;other biological processes","plasma membrane;other membranes;other cell component","","CLPTM1","ENSG00000104853","","","",3461.2,3653.7,3695.4,3384.4,3465.6,5415.3,0.8813726529314407,-0.18217596125393373,0.5078679245353523,0.2942492150847457,0.6512292386717352,0.1862661088732641,5700]
["O96006","zinc finger BED domain-containing protein 1 [OS=Homo sapiens]",1,1,1,1,694,78.1,6.1,2.51,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBED1","ENSG00000214717","","SUMOylation of chromatin organization proteins","",29,32.9,36.9,52.4,46.8,30.5,0.7617579028527371,-0.3925955326670217,0.21264678513370677,0.6723411787117508,0.4594251707189662,0.3377852146157584,3383]
["O96007","molybdopterin synthase catalytic subunit [OS=Homo sapiens]",20,4,5,4,188,20.9,5.44,12.16,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","MOCS2","ENSG00000164172","Folate biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Sulfur relay system","Molybdenum cofactor biosynthesis","",367.1,413,401.6,500.4,472.2,245.9,0.9697989331144851,-0.0442424282755037,0.8879445920831552,0.05161413343683004,0.9243678996632647,0.03415514458753203,7021]
["O96008","Mitochondrial import receptor subunit TOM40 homolog [OS=Homo sapiens]",50,14,97,14,361,37.9,7.25,383.07,"cell organization and biogenesis;transport","other membranes;cytosol;mitochondrion;other cell component","transporter activity","TOMM40","ENSG00000130204","Amyotrophic lateral sclerosis; Pathways of neurodegeneration","Mitochondrial protein import; PINK1-PRKN Mediated Mitophagy","IL-18 signaling pathway",6145.1,6162.3,6288,5441.5,5074.6,5515.4,1.1599288899978168,0.2140363629458567,0.003994220424368778,2.3985679719025863,0.07390824577648455,1.1313071056450734,395]
["O96011-1","Peroxisomal membrane protein 11B [OS=Homo sapiens]",31,8,22,8,259,28.4,9.85,65.56,"cell organization and biogenesis;signal transduction","other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PEX11B","ENSG00000131779; ENSPPAG00000024465; ENSPTRG00000001203","Peroxisome","Class I peroxisomal membrane protein import","",2708.5,2490.8,2510,2543.1,2369.1,3112.4,0.9607083219101265,-0.057829610201239785,0.6778533966107168,0.1688642234301921,0.7754625881715024,0.11043914967835908,6389]
["O96013-1","serine/threonine-protein kinase PAK 4 [OS=Homo sapiens]",2,1,1,1,591,64,9.73,4.48,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;ER/Golgi;other cell component","kinase activity;other molecular function","PAK4","ENSG00000130669","ErbB signaling pathway; Ras signaling pathway; Axon guidance; Focal adhesion; T cell receptor signaling pathway; Regulation of actin cytoskeleton; Human immunodeficiency virus 1 infection; MicroRNAs in cancer; Renal cell carcinoma","CDC42 GTPase cycle; RAC3 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; Activation of RAC1; RHOH GTPase cycle","Integrin-mediated cell adhesion; Focal adhesion; Ras signaling; Pancreatic adenocarcinoma pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; 22q11.2 copy number variation syndrome; Malignant pleural mesothelioma; Regulation of actin cytoskeleton; ErbB signaling pathway",123.4,121,140.2,151.7,172,269.7,0.648129423660263,-0.6256461641403694,0.13250394050110204,0.8777712061616052,0.3786048870690206,0.4218137844202674,2558]
["O96017-1","Serine/threonine-protein kinase Chk2 [OS=Homo sapiens]",25,10,20,10,543,60.9,5.91,64.49,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","CHEK2","ENSG00000183765","Cell cycle; p53 signaling pathway; Cellular senescence; Human T-cell leukemia virus 1 infection","Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Regulation of TP53 Activity through Methylation; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Stabilization of p53","miRNA regulation of DNA damage response; Cell cycle; ATM signaling in development and disease ; miRNA regulation of p53 pathway in prostate cancer; DNA damage response",1162.4,1195.8,1179.4,1221.8,1123,1203.8,0.9969001859888406,-0.004479031976714209,0.9139609126143133,0.039072377350309696,0.9432561861477008,0.02537033788842894,7082]
["O96018","amyloid-beta A4 precursor protein-binding family A member 3 [OS=Homo sapiens]",14,5,7,5,575,61.4,4.94,15.3,"cell-cell signaling;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","enzyme regulator activity;other molecular function","APBA3","ENSG00000011132","","Neurexins and neuroligins","",556.4,553.6,563.2,629.5,584.2,574.5,0.9356895201878984,-0.09589819968607045,0.08958153968554006,1.0477814773770708,0.32349381104822744,0.4901340236608593,2024]
["O96019-1","Actin-like protein 6A [OS=Homo sapiens]",37,12,55,12,429,47.4,5.6,163.76,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;nucleus","other molecular function","ACTL6A","ENSCANG00000034249; ENSCATG00000017467; ENSCCAG00000029449; ENSCJAG00000013036; ENSCSAG00000013017; ENSG00000136518; ENSGGOG00000015710; ENSMFAG00000030153; ENSMMUG00000009742; ENSPANG00000024431; ENSPPAG00000031814; ENSPTRG00000023973; ENSRBIG00000036584; ENSRROG00000035215","Thermogenesis; Hepatocellular carcinoma","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines; UCH proteinases; HATs acetylate histones; DNA Damage Recognition in GG-NER","Gastric cancer network 1; Tumor suppressor activity of SMARCB1; Thermogenesis",8516.1,8449.2,8567,9685.1,10079.6,8348.3,0.9082026108917585,-0.1389139106739174,0.17664341441057557,0.7529025492195747,0.4273706441333654,0.36919531260888216,3021]
["O96028-1","Histone-lysine N-methyltransferase NSD2 [OS=Homo sapiens]",13,14,20,14,1365,152.2,8.69,51.59,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NSD2","ENSG00000109685","Lysine degradation; Metabolic pathways; Transcriptional misregulation in cancer","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; PKMTs methylate histone lysines; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)","",1212.7,1200.5,1180.3,1394.4,1516.1,1245.2,0.8647159323339028,-0.2097018237810351,0.07640051609782761,1.1169037076850221,0.3007061777916112,0.5218576495408295,1857]
["P00156","cytochrome b [OS=Homo sapiens]",2,1,1,1,380,42.7,8.05,2.39,"other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MT-CYB","ENSG00000198727","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly",209.8,216.5,229.2,164.5,181.3,105.5,1.4524706403722578,0.5385090018966294,0.045253236367376444,1.344350355989561,0.23162178193918376,0.6352206015457438,1428]
["P00167-1","Cytochrome b5 [OS=Homo sapiens]",49,5,12,5,134,15.3,4.96,47.76,"other metabolic processes;transport;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cell component","transporter activity;other molecular function","CYB5A","ENSG00000166347; ENSPTRG00000010111","","Vitamin C (ascorbate) metabolism","Oxidation by cytochrome P450",1747.9,1866.3,1653.1,2164.5,2172.5,1578.4,0.8904385164147817,-0.1674120962789402,0.35381686511612104,0.45122146975218225,0.5550649210417963,0.2556562183164302,4659]
["P00338-1","L-lactate dehydrogenase A chain [OS=Homo sapiens]",66,23,487,21,332,36.7,8.27,1452.1,"other metabolic processes;stress response;developmental processes;other biological processes","cytosol;other cell component","other molecular function","HEL-S-133P; LDHA","ENSG00000134333; ENSG00000288299","Glycolysis / Gluconeogenesis; Cysteine and methionine metabolism; Pyruvate metabolism; Propanoate metabolism; Metabolic pathways; HIF-1 signaling pathway; Glucagon signaling pathway; Central carbon metabolism in cancer","Pyruvate metabolism","Cori cycle; HIF1A and PPARG regulation of glycolysis; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling pathway; Amino acid metabolism; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - VitD3 signaling; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Orexin receptor pathway; CCL18 signaling pathway; Glycolysis and gluconeogenesis",51533.4,50779.4,51471.5,51375.8,45637.8,33748.3,1.1760635169724512,0.23396597951661535,0.21378441237375637,0.6700239636120567,0.46025044772895,0.33700578034460427,3395]
["P00367","Glutamate dehydrogenase 1, mitochondrial [OS=Homo sapiens]",47,24,162,24,558,61.4,7.8,471.84,"other metabolic processes;other biological processes","mitochondrion;ER/Golgi;other cell component","other molecular function","GLUD1","ENSG00000148672","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Nitrogen metabolism; Metabolic pathways; Carbon metabolism; Necroptosis; Proximal tubule bicarbonate reclamation","Transcriptional activation of mitochondrial biogenesis; Glutamate and glutamine metabolism","VEGFA-VEGFR2 signaling pathway; Amino acid metabolism; Metabolic reprogramming in colon cancer; 22q11.2 copy number variation syndrome; Amino acid metabolism pathway excerpt: histidine catabolism extension",17846.2,17362.9,17284.1,15392.9,15169.1,18358.2,1.073037313829461,0.10170024528429808,0.3170792297972742,0.4988322054023168,0.537087390634595,0.26995504356957223,4315]
["P00374","dihydrofolate reductase [OS=Homo sapiens]",41,7,22,7,187,21.4,7.42,58.4,"cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;mitochondrion","nucleic acid binding activity;other molecular function","DHFR","ENSG00000228716","One carbon pool by folate; Folate biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Antifolate resistance","G1/S-Specific Transcription; Metabolism of folate and pterines; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation","Fluoropyrimidine activity; Folate metabolism; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration and one-carbon metabolism; Ethanol effects on histone modifications; Nucleotide metabolism",2143.9,2165.5,2011.3,2935.6,2891.6,1746.5,0.8345590662423915,-0.2609139343835342,0.3469358984727173,0.4597507601118627,0.552813272713558,0.25742153835987236,4587]
["P00387","NADH-cytochrome b5 reductase 3 [OS=Homo sapiens]",45,12,80,12,301,34.2,7.59,261.81,"other metabolic processes;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CYB5R3","ENSG00000100243","Amino sugar and nucleotide sugar metabolism","Neutrophil degranulation; Phase I - Functionalization of compounds; Vitamin C (ascorbate) metabolism","Oxidation by cytochrome P450",7652.2,7756.5,7550.7,7180,7109.5,8334.2,1.014838421655167,0.02125004580150059,0.7942497376190691,0.10004291997026317,0.8596433188594367,0.06568170780647267,6753]
["P00390","Glutathione reductase, mitochondrial [OS=Homo sapiens]",47,18,83,18,522,56.2,8.5,280.8,"other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion","other molecular function","GSR","ENSG00000104687","Glutathione metabolism; Metabolic pathways; Thyroid hormone synthesis; Diabetic cardiomyopathy","","Glutathione metabolism; Selenium micronutrient network; Nuclear receptors meta-pathway; NRF2 pathway; Amino acid metabolism; One-carbon metabolism and related pathways; Oxidative stress response; Vitamin D-sensitive calcium signaling in depression; Sulfation biotransformation reaction; Metapathway biotransformation Phase I and II",9747.8,9541.3,9492.3,9536.3,8739.1,9030.8,1.054024360767884,0.07590821114294106,0.11591701778920244,0.9358528005385507,0.35899893348359346,0.4449068416246843,2360]
["P00395","Cytochrome c oxidase subunit 1 [OS=Homo sapiens]",2,1,2,1,513,57,6.7,6.58,"other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MT-CO1","ENSG00000198804","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Electron transport chain: OXPHOS system in mitochondria; Effects of nitric oxide; Nonalcoholic fatty liver disease; Neuroinflammation; Mitochondrial complex IV assembly",312,308.4,334.2,362,315,707.4,0.6895405952036983,-0.536292605113244,0.3121703801031937,0.5056083068085117,0.5334704952476602,0.27288959518134975,4277]
["P00403","Cytochrome c oxidase subunit 2 [OS=Homo sapiens]",31,6,33,6,227,25.5,4.82,81.38,"other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MT-CO2","ENSG00000198712","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Cytoprotection by HMOX1; Respiratory electron transport; TP53 Regulates Metabolic Genes","Electron transport chain: OXPHOS system in mitochondria; Endothelin pathways; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Neuroinflammation; Mitochondrial complex IV assembly; CCL18 signaling pathway",4511.3,4663.7,4726.2,4048.8,4186.1,5395.3,1.0198823201420375,0.028402695390898354,0.8447687407893141,0.07326216483142677,0.8960114245289649,0.04768645286214229,6891]
["P00439","phenylalanine-4-hydroxylase [OS=Homo sapiens]",2,1,1,1,452,51.8,6.6,0,"other metabolic processes","cytosol","other molecular function","PAH","ENSG00000171759","Phenylalanine metabolism; Phenylalanine, tyrosine and tryptophan biosynthesis; Folate biosynthesis; Metabolic pathways; Biosynthesis of amino acids","Phenylketonuria; Phenylalanine metabolism","Biogenic amine synthesis; Sudden infant death syndrome (SIDS) susceptibility pathways",32.6,35,39.7,53,42.1,26.4,0.8831275720164609,-0.17930623773662144,0.5857567324012716,0.23228271113403928,0.7066010822117336,0.15082570174659615,6059]
["P00441","Superoxide dismutase [Cu-Zn] [OS=Homo sapiens]",97,16,152,16,154,15.9,6.13,551.15,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","SOD1","ENSG00000142168","Peroxisome; Longevity regulating pathway; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Platelet degranulation ; Detoxification of Reactive Oxygen Species","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; AGE/RAGE pathway; Dopamine metabolism; Amyotrophic lateral sclerosis (ALS); Copper homeostasis; Physico-chemical features and toxicity-associated pathways; One-carbon metabolism and related pathways; Oxidative stress response; Extracellular vesicles in the crosstalk of cardiac cells",18776,17627.3,17825.5,18055.1,17869.9,29445.5,0.8295607345821127,-0.2695804858908737,0.38872535576930195,0.41035713029349974,0.5727058305417916,0.24206839544571232,4961]
["P00450","Ceruloplasmin [OS=Homo sapiens]",1,1,1,1,1065,122.1,5.72,2.11,"transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi","other molecular function","CP","ENSG00000047457","Porphyrin and chlorophyll metabolism; Ferroptosis","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Metal ion SLC transporters; Iron uptake and transport; Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages); Defective CP causes aceruloplasminemia (ACERULOP)","Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway",48.8,53.5,55.7,39.3,43,64.3,{"$f":"AVERAGE(S898:U898)/AVERAGE(V898:X898)","v":1.0777626193724419},{"$f":"LOG(Y898,2)","v":0.10803945493065323},{"$f":"TTEST(S898:U898,V898:X898,2,2)","v":0.6615539634515968},{"$f":"-LOG10(AA898)","v":0.17943472430583815},{"$f":"AA898*7309/AE898","v":0.763267232654731},{"$f":"-LOG10(AC898)","v":0.11732338164132536},6335]
["P00488","Coagulation factor XIII A chain [OS=Homo sapiens]",1,1,2,1,732,83.2,6.09,2.76,"protein metabolism;other metabolic processes;stress response","non-structural extracellular;other cell component","other molecular function","F13A1","ENSG00000124491","Complement and coagulation cascades; Coronavirus disease","Platelet degranulation ; Interleukin-4 and Interleukin-13 signaling; Common Pathway of Fibrin Clot Formation","Complement system",81.6,73.3,83,66.3,70.2,52.8,1.2567353407290016,0.3296808607214295,0.056100527740621624,1.2510330532935388,0.256755640110334,0.5904800075480487,1597]
["P00491","purine nucleoside phosphorylase [OS=Homo sapiens]",66,15,60,15,289,32.1,6.95,220.04,"other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","PNP","ENSG00000198805","Purine metabolism; Pyrimidine metabolism; Nicotinate and nicotinamide metabolism; Metabolic pathways","Neutrophil degranulation; Purine catabolism; Purine salvage","VEGFA-VEGFR2 signaling pathway",6912,6925.9,6796.1,5834.4,5076.4,5116.8,1.287404227707205,0.36446511163480255,0.003543578007679904,2.4505580023177234,0.06925136806987277,1.1595716426342308,374]
["P00492","Hypoxanthine-guanine phosphoribosyltransferase [OS=Homo sapiens]",62,10,57,10,218,24.6,6.68,199.36,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","other molecular function","HPRT1","ENSG00000165704","Purine metabolism; Drug metabolism; Metabolic pathways","Purine salvage","Mesodermal commitment pathway; Nucleotide metabolism",6451.6,6596.1,6371.7,6218.4,6605.2,3693.7,1.1757006290374337,0.23352075066210498,0.35014298735196037,0.4557545672592856,0.5541782361532002,0.2563505339564701,4618]
["P00505","Aspartate aminotransferase, mitochondrial [OS=Homo sapiens]",51,22,164,22,430,47.5,9.01,475.51,"other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;other cell component","other molecular function","GOT2","ENSG00000125166","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Cysteine and methionine metabolism; Arginine and proline metabolism; Tyrosine metabolism; Phenylalanine metabolism; Phenylalanine, tyrosine and tryptophan biosynthesis; Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids; Fat digestion and absorption","Gluconeogenesis; Glyoxylate metabolism and glycine degradation; Aspartate and asparagine metabolism; Glutamate and glutamine metabolism; Degradation of cysteine and homocysteine","Alanine and aspartate metabolism; Amino acid metabolism; Metabolic reprogramming in colon cancer; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis and gluconeogenesis",24774.2,24557.1,24724.4,21795,20893.5,16135.4,1.2589389686844974,0.33220834524086096,0.044567742273746894,1.350979365978635,0.23069803702465727,0.636956100810447,1412]
["P00519","Tyrosine-protein kinase ABL1 [OS=Homo sapiens]",1,1,1,1,1130,122.8,8.66,0,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;kinase activity;other molecular function","ABL1","ENSG00000097007","ErbB signaling pathway; Ras signaling pathway; Cell cycle; Axon guidance; Neurotrophin signaling pathway; Pathogenic Escherichia coli infection; Pathways in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chronic myeloid leukemia; Viral myocarditis","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Factors involved in megakaryocyte development and platelet production; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RHO GTPases Activate WASPs and WAVEs; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Myogenesis; Cyclin D associated events in G1; RUNX2 regulates osteoblast differentiation; HDR through Single Strand Annealing (SSA); Role of ABL in ROBO-SLIT signaling","miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; TP53 network; Cell cycle; Integrated breast cancer pathway; Microtubule cytoskeleton regulation; Pathogenic Escherichia coli infection; Retinoblastoma gene in cancer; ATM signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Imatinib and chronic myeloid leukemia; VEGFA-VEGFR2 signaling pathway; Ras signaling; Acute viral myocarditis; EGF/EGFR signaling pathway; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)",23.5,22.2,25.3,32.6,41,44.8,0.5996621621621623,-0.737778151236905,0.01312256330059219,1.8819813236059957,0.13120768148293888,0.8820407386798832,731]
["P00558","phosphoglycerate kinase 1 [OS=Homo sapiens]",76,29,692,24,417,44.6,8.1,2197.3,"protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;other membranes;cytosol","kinase activity;other molecular function","PGK1","ENSG00000102144","Glycolysis / Gluconeogenesis; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; HIF-1 signaling pathway","Glycolysis; Gluconeogenesis; Manipulation of host energy metabolism","Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Glycolysis and gluconeogenesis",100159,98329,99515.3,96243.4,92534.9,93015.5,1.0575225572741487,0.08068843679247702,0.013528256991819228,1.8687581551834616,0.13343863745372028,0.8747184012788168,741]
["P00568","Adenylate kinase isoenzyme 1 [OS=Homo sapiens]",39,6,16,6,194,21.6,8.63,37.83,"other metabolic processes","cytosol;cytoskeleton;other cell component","kinase activity;other molecular function","AK1","ENSG00000106992","Purine metabolism; Thiamine metabolism; Metabolic pathways; Biosynthesis of cofactors","Interconversion of nucleotide di- and triphosphates","",1240.1,1211.6,1137.1,1145.7,1171.7,983.2,1.087317457431982,0.12077321671978808,0.2220385917468113,0.6535715357922057,0.46621087821816826,0.3314175971925212,3481]
["P00734","Prothrombin [OS=Homo sapiens]",6,3,3,3,622,70,5.9,10.7,"protein metabolism;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi","signal transduction activity or receptor binding;other molecular function","F2","ENSG00000180210","Phospholipase D signaling pathway; Neuroactive ligand-receptor interaction; Complement and coagulation cascades; Platelet activation; Regulation of actin cytoskeleton; Pathogenic Escherichia coli infection; Coronavirus disease; Pathways in cancer","Cell surface interactions at the vascular wall; Regulation of Complement cascade; G alpha (q) signalling events; Peptide ligand-binding receptors; Thrombin signalling through proteinase activated receptors (PARs); Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Intrinsic Pathway of Fibrin Clot Formation; Common Pathway of Fibrin Clot Formation; Defective F8 cleavage by thrombin; Gamma-carboxylation of protein precursors; Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus; Removal of aminoterminal propeptides from gamma-carboxylated proteins; Platelet Aggregation (Plug Formation); Defective factor XII causes hereditary angioedema","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Blood clotting cascade; IL1 and megakaryocytes in obesity; Regulation of actin cytoskeleton; Complement and coagulation cascades",192.9,223.1,215.3,230,200.1,159.6,1.0705443445819907,0.09834455694107239,0.5680313281919116,0.24562771132123978,0.6963671549404028,0.15716172113387883,5962]
["P00747","Plasminogen [OS=Homo sapiens]",4,3,9,3,810,90.5,7.24,19.13,"cell organization and biogenesis;protein metabolism;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","PLG","ENSG00000122194","Neuroactive ligand-receptor interaction; Complement and coagulation cascades; Staphylococcus aureus infection; Influenza A","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Signaling by PDGF; Platelet degranulation ; Activation of Matrix Metalloproteinases; Dissolution of Fibrin Clot","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Blood clotting cascade; Complement system; Fibrin complement receptor 3 signaling pathway; Complement and coagulation cascades",1289,1246.3,1349,1165.8,1215.3,1320,1.0494987976547512,0.06970051382537786,0.32402207460392957,0.4894254016695994,0.5392252603096815,0.2682297712276619,4392]
["P00813","adenosine deaminase [OS=Homo sapiens]",69,19,119,19,363,40.7,5.95,352.3,"cell adhesion;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","ADA","ENSG00000196839","Purine metabolism; Metabolic pathways; Primary immunodeficiency","Purine salvage","",10620.4,10693.3,10654.7,10040.6,9749.2,8942.4,1.11263321291095,0.1539780768436102,0.03057136395352161,1.5146851846211902,0.19914982097708506,0.7008200796573599,1122]
["P00846","ATP synthase subunit A [OS=Homo sapiens]",4,1,5,1,226,24.8,10.1,16.69,"other metabolic processes;stress response;transport;other biological processes","other membranes;mitochondrion","transporter activity","MT-ATP6","ENSG00000198899","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation",717.7,810.2,908.8,723.5,859.9,969,0.9546701144021311,-0.06692579790054218,0.6901197892618641,0.1610755189727796,0.7842172791845406,0.10556359282920144,6432]
["P00918","Carbonic anhydrase 2 [OS=Homo sapiens]",26,5,6,5,260,29.2,7.4,18.9,"other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","CA2","ENSG00000104267","Nitrogen metabolism; Metabolic pathways; Proximal tubule bicarbonate reclamation; Collecting duct acid secretion; Gastric acid secretion; Pancreatic secretion; Bile secretion","Reversible hydration of carbon dioxide; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide","Proximal tubule transport",289.2,285.2,291.9,295.9,269.3,1146.1,0.5062233389820604,-0.9821540717187351,0.3833602872464907,0.4163928782159106,0.5686990743829106,0.24511747860684677,4927]
["P00966","Argininosuccinate synthase [OS=Homo sapiens]",5,3,3,3,412,46.5,8.02,6.49,"other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","ASS1","ENSG00000130707","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Metabolic pathways; Biosynthesis of amino acids; Fluid shear stress and atherosclerosis","Urea cycle","Alanine and aspartate metabolism; Amino acid metabolism",430.8,405.6,427.7,416.4,386.2,712.9,0.8341141537446388,-0.2616832558560182,0.46766997466523486,0.3300605117587793,0.6250136852858295,0.20411047324944515,5469]
["P00973-1","2'-5'-oligoadenylate synthase 1 [OS=Homo sapiens]",18,6,13,6,400,46,8.22,35.48,"cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component","nucleic acid binding activity;other molecular function","OAS1","ENSG00000089127","NOD-like receptor signaling pathway; Hepatitis C; Measles; Influenza A; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease","OAS antiviral response; Interferon gamma signaling; Interferon alpha/beta signaling","Immune response to tuberculosis; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; Type II interferon signaling (IFNG)",866.5,856.2,882.2,941.5,876.9,728.7,1.0226924737937262,0.03237238825834216,0.776507090174172,0.1098545744370832,0.8473410453990777,0.0719417557569583,6698]
["P01008","Antithrombin-III [OS=Homo sapiens]",2,1,2,1,464,52.6,6.71,2.3,"stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi","enzyme regulator activity;other molecular function","SERPINC1","ENSG00000117601","Complement and coagulation cascades","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Intrinsic Pathway of Fibrin Clot Formation; Common Pathway of Fibrin Clot Formation","Complement and coagulation cascades",292,281,281.6,228.8,251,486.2,0.8846790890269152,-0.17677387204202383,0.6756896693104789,0.17025272099769898,0.7739564007193684,0.11128350373611745,6381]
["P01023","alpha-2-macroglobulin [OS=Homo sapiens]",1,2,4,2,1474,163.2,6.46,8.32,"other biological processes","non-structural extracellular;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","A2M","ENSG00000175899","Complement and coagulation cascades","Platelet degranulation ; Intrinsic Pathway of Fibrin Clot Formation; Degradation of the extracellular matrix; HDL assembly","Complement system; Complement and coagulation cascades",827.5,855.5,1064.8,855.8,697,913.6,1.114093415504379,0.1558702061380795,0.3969960607590873,0.4012138025544643,0.5762947781704407,0.23935531556012815,5035]
["P01024","Complement C3 [OS=Homo sapiens]",1,1,1,1,1663,187,6.4,3.6,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity","C3","ENSG00000125730","Neuroactive ligand-receptor interaction; Phagosome; Complement and coagulation cascades; Neutrophil extracellular trap formation; Alcoholic liver disease; Shigellosis; Pertussis; Legionellosis; Leishmaniasis; Chagas disease; Staphylococcus aureus infection; Tuberculosis; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Coronavirus disease; Viral carcinogenesis; Systemic lupus erythematosus","Purinergic signaling in leishmaniasis infection; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; G alpha (i) signalling events; Neutrophil degranulation; Peptide ligand-binding receptors; Alternative complement activation; Activation of C3 and C5","Allograft Rejection; Complement system; TYROBP causal network in microglia; Cells and molecules involved in local acute inflammatory response ; 16p11.2 distal deletion syndrome; Complement system in neuronal development and plasticity; Acquired partial lipodystrophy / Barraquer-Simons syndrome; Complement activation; Complement and coagulation cascades",104.9,90.2,88.9,75.1,71,60.7,1.3733075435203095,0.4576547440771098,0.018298066774547227,1.7375947918814254,0.15605667451011165,0.8067176519206506,857]
["P01111","GTPase NRas [OS=Homo sapiens]",61,8,33,4,189,21.2,5.17,92.25,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi","other molecular function","NRAS","ENSG00000213281","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; Chemokine signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Mitophagy; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Apelin signaling pathway; Gap junction; Signaling pathways regulating pluripotency of stem cells; C-type lectin receptor signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Thermogenesis; Long-term potentiation; Neurotrophin signaling pathway; Cholinergic synapse; Serotonergic synapse; Long-term depression; Regulation of actin cytoskeleton; Insulin signaling pathway; GnRH signaling pathway; Estrogen signaling pathway; Melanogenesis; Prolactin signaling pathway; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Relaxin signaling pathway; GnRH secretion; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Alzheimer disease; Pathways of neurodegeneration; Alcoholism; Hepatitis C; Hepatitis B; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Endometrial cancer; Glioma; Prostate cancer; Thyroid cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis","Neutrophil degranulation; Tie2 Signaling; FCERI mediated MAPK activation; Regulation of RAS by GAPs; Signaling by BRAF and RAF1 fusions; Signaling by SCF-KIT; Downstream signal transduction; DAP12 signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; GRB2 events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; GRB2 events in EGFR signaling; SHC1 events in EGFR signaling; NCAM signaling for neurite out-growth; Signaling by FGFR1 in disease; p38MAPK events; SHC-mediated cascade:FGFR1; FRS-mediated FGFR1 signaling; SHC-mediated cascade:FGFR2; FRS-mediated FGFR2 signaling; Signaling by FGFR2 in disease; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ; SHC-mediated cascade:FGFR3; FRS-mediated FGFR3 signaling; FRS-mediated FGFR4 signaling; SHC-mediated cascade:FGFR4; Signaling by FGFR3 point mutants in cancer; FLT3 Signaling; Activated NTRK2 signals through FRS2 and FRS3; RAS processing; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; CD209 (DC-SIGN) signaling; Activation of RAS in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; SOS-mediated signalling; SHC-related events triggered by IGF1R; Signaling by FGFR4 in disease; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants; RAS signaling downstream of NF1 loss-of-function variants; Insulin receptor signalling cascade; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; MET activates RAS signaling; Signaling by FGFR3 fusions in cancer; Activated NTRK2 signals through RAS; Activated NTRK3 signals through RAS; Constitutive Signaling by Overexpressed ERBB2; RAS GTPase cycle mutants; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants","Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; RalA downstream regulated genes; TNF-alpha signaling pathway; Aryl hydrocarbon receptor Netpath; Bladder cancer; Extracellular vesicle-mediated signaling in recipient cells; RAC1/PAK1/p38/MMP2 pathway; G protein signaling pathways; BDNF-TrkB signaling; MAPK signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MAPK cascade; Ras signaling; Non-small cell lung cancer; Breast cancer pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Synaptic signaling pathways associated with autism spectrum disorder; Hippo-Merlin signaling dysregulation; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; EGFR tyrosine kinase inhibitor resistance; Kisspeptin/kisspeptin receptor system in the ovary; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; ErbB signaling pathway; DNA damage response (only ATM dependent); Serotonin receptor 2 and ELK-SRF/GATA4 signaling",1562,1681.9,1679.8,1441.5,1523.1,1400.7,1.1279178979680662,0.17366205665055237,0.025404581250416006,1.5950879592710028,0.18133016050711973,0.7415299540268417,1024]
["P01116-2","Isoform 2B of GTPase KRas [OS=Homo sapiens]",61,8,40,4,188,21.4,8.12,99.1,"","","","KRAS","","","","",1374.5,1405.1,1377.1,1359.6,1405.8,1656.1,0.9401108221191903,-0.08909726033349935,0.3945732065479697,0.4038724088036403,0.5747181280707673,0.24054510389825906,5018]
["P01130","Low-density lipoprotein receptor [OS=Homo sapiens]",20,16,21,16,860,95.3,5.05,57.91,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","LDLR","ENSG00000130164","Endocytosis; Ovarian steroidogenesis; Aldosterone synthesis and secretion; Cortisol synthesis and secretion; Cushing syndrome; Bile secretion; Cholesterol metabolism; Toxoplasmosis; Hepatitis C; Lipid and atherosclerosis","Retinoid metabolism and transport; Cargo recognition for clathrin-mediated endocytosis; LDL clearance; Chylomicron clearance","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Oncostatin M signaling pathway; PCSK9-mediated LDL receptor degradation; Evolocumab mechanism to reduce LDL cholesterol; Lipid particles composition; Wnt signaling pathway and pluripotency; Statin inhibition of cholesterol production; Bile acids synthesis and enterohepatic circulation ; Metabolic pathway of LDL, HDL and TG, including diseases; Orexin receptor pathway; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5; DNA damage response (only ATM dependent)",2206.8,2264,2350.7,3481.6,4009.7,2908,0.6559576125316128,-0.608325502858331,0.020530673296289586,1.6875968078593897,0.16617795251670053,0.7794265962889226,903]
["P01591","Immunoglobulin J chain [OS=Homo sapiens]",38,3,20,3,159,18.1,5.24,60.44,"cell organization and biogenesis;stress response;other biological processes","non-structural extracellular","signal transduction activity or receptor binding;other molecular function","JCHAIN","ENSG00000132465","","Cell surface interactions at the vascular wall; Scavenging of heme from plasma","",876,897.2,970,1289,1348.9,1275,0.7010657057425439,-0.5123784310984755,4.2979050001025926E-4,3.366743188283198,0.023798020943749887,1.623459157605075,132]
["P01834","immunoglobulin kappa constant [OS=Homo sapiens]",19,1,1,1,107,11.8,6.52,5.11,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","IGKC","","","Initial triggering of complement; Classical antibody-mediated complement activation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; Scavenging of heme from plasma; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Regulation of Complement cascade; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers","",25,23.6,43.9,16.3,26.6,23.5,1.3930722891566263,0.4782701240567495,0.2947309424524665,0.5305742671669263,0.5237511447568874,0.28087501479212845,4113]
["P01854","immunoglobulin heavy constant epsilon [OS=Homo sapiens]",4,1,1,1,428,47,8.06,2.5,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","IGHE","ENSG00000211891; ENSG00000276192","","FCERI mediated NF-kB activation; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; Interleukin-4 and Interleukin-13 signaling","",163.1,177.8,145.6,170.6,157.6,79.9,1.1921097770154374,0.2535170944103734,0.4301178923939885,0.36641249093497624,0.5964203520219431,0.2244475452659607,5271]
["P01857","Immunoglobulin heavy constant gamma 1 [OS=Homo sapiens]",11,2,6,2,330,36.1,8.19,24.71,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","IGHG1","ENSG00000211896; ENSG00000277633","","Initial triggering of complement; Classical antibody-mediated complement activation; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Regulation of Complement cascade; Interleukin-4 and Interleukin-13 signaling","Interactions of natural killer cells in pancreatic cancer",373.6,404.9,371.8,438.1,478.4,278.6,0.9625135971885199,-0.05512117345699325,0.8213426435815645,0.08547562829726428,0.8806210036581568,0.05521096041174757,6817]
["P01889","HLA class I histocompatibility antigen, B-7 alpha chain [OS=Homo sapiens]",43,13,95,3,362,40.4,5.85,312.16,"stress response;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","HLA-B","ENSG00000234745","Endocytosis; Phagosome; Cellular senescence; Cell adhesion molecules; Antigen processing and presentation; Natural killer cell mediated cytotoxicity; Type I diabetes mellitus; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Viral carcinogenesis; Autoimmune thyroid disease; Allograft rejection; Graft-versus-host disease; Viral myocarditis","DAP12 interactions; Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ER-Phagosome pathway; Interferon gamma signaling; Interferon alpha/beta signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Endosomal/Vacuolar pathway","Proteasome degradation; Allograft Rejection; Ebola virus pathway in host; Type II interferon signaling (IFNG)",3457.8,3615.7,3591,2784,3336.8,5387.5,0.9266790055872719,-0.10985840786476274,0.7408772462548601,0.13025374301985737,0.8228341882505352,0.08468767193588031,6581]
["P01903","HLA class II histocompatibility antigen, DR alpha chain [OS=Homo sapiens]",26,5,14,5,254,28.6,5,51.51,"other biological processes","plasma membrane;other membranes;other cytoplasmic organelle","","HLA-DRA","","","","",1234.4,1283.3,1278.3,1142.2,1217.1,1160.1,1.0785929419787461,0.10915049838482901,0.02820466292202455,1.5496790862232703,0.19034892086526078,0.7204495809646176,1083]
["P01911","HLA class II histocompatibility antigen, DRB1-15 beta chain [OS=Homo sapiens]",23,6,13,2,266,29.9,7.74,31.26,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","HLA-DRB1","ENSG00000196126","Phagosome; Cell adhesion molecules; Antigen processing and presentation; Hematopoietic cell lineage; Th1 and Th2 cell differentiation; Th17 cell differentiation; Intestinal immune network for IgA production; Type I diabetes mellitus; Leishmaniasis; Toxoplasmosis; Staphylococcus aureus infection; Tuberculosis; Influenza A; Human T-cell leukemia virus 1 infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Asthma; Autoimmune thyroid disease; Inflammatory bowel disease; Systemic lupus erythematosus; Rheumatoid arthritis; Allograft rejection; Graft-versus-host disease; Viral myocarditis","Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling","Allograft Rejection; Vitamin D receptor pathway; Ebola virus pathway in host; Cancer immunotherapy by PD-1 blockade; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Genes associated with the development of rheumatoid arthritis; Network map of SARS-CoV-2 signaling pathway; Cytokines and inflammatory response",409.8,431.2,391.5,399.2,444.3,699.3,0.7988721804511278,-0.3239634044761255,0.33353487226276585,0.47685875233351926,0.5443962441644832,0.26408487969255773,4478]
["P02042","Hemoglobin subunit delta [OS=Homo sapiens]",13,2,25,1,147,16,8.05,63.89,"other metabolic processes;transport;other biological processes","cytosol;other cell component","other molecular function","HBD","ENSG00000223609","","Factors involved in megakaryocyte development and platelet production","VEGFA-VEGFR2 signaling pathway",959.5,917.9,929.6,710.8,844.7,685.9,1.2523422860712055,0.3246289288260257,0.020686006628440768,1.6843233404904872,0.1668808194782269,0.7775935762833273,906]
["P02533","Keratin, type I cytoskeletal 14 [OS=Homo sapiens]",42,19,57,6,472,51.5,5.16,160.3,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KRT14","ENSG00000186847","Estrogen signaling pathway; Staphylococcus aureus infection","Formation of the cornified envelope; Type I hemidesmosome assembly","Corticotropin-releasing hormone signaling pathway",2938.8,3693.5,2879.8,2558.6,3424,8519.1,0.655929994414448,-0.6083862466605703,0.4258105197841107,0.3707836133820686,0.5934876218730102,0.2265883345161423,5244]
["P02538","Keratin, type II cytoskeletal 6A [OS=Homo sapiens]",33,23,73,4,564,60,8,179.44,"cell organization and biogenesis;stress response;other biological processes","cytosol;cytoskeleton","cytoskeletal activity","KRT6A","ENSG00000205420","","Formation of the cornified envelope","Ectoderm differentiation; Ectoderm differentiation",2930.5,2952.4,2973.3,2384.4,3413.9,15991.8,0.4064322788789405,-1.2989131092898718,0.38013290569822566,0.42006453464679283,0.5679459132764373,0.24569302112706776,4892]
["P02545","Prelamin-A/C [OS=Homo sapiens]",66,46,249,43,664,74.1,7.02,742.27,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","LMNA","ENSG00000160789","Apoptosis; Hypertrophic cardiomyopathy; Arrhythmogenic right ventricular cardiomyopathy; Dilated cardiomyopathy","Signaling by BRAF and RAF1 fusions; XBP1(S) activates chaperone genes","Arrhythmogenic right ventricular cardiomyopathy; Adipogenesis; Fas ligand pathway and stress induction of heat shock proteins; Lamin A-processing pathway; Nephrotic syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome",27471.3,26716.6,27590.5,26818.7,26635.8,27545.9,1.0096048908400452,0.013790804313436683,0.5424720934359177,0.2656225984536677,0.6778814380104501,0.16884625793301702,5849]
["P02647","Apolipoprotein A-I [OS=Homo sapiens]",8,2,13,1,267,30.8,5.76,31.99,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;other molecular function","APOA1","ENSG00000118137","PPAR signaling pathway; Fat digestion and absorption; Vitamin digestion and absorption; Cholesterol metabolism; African trypanosomiasis; Lipid and atherosclerosis","PPARA activates gene expression; Platelet degranulation ; Scavenging of heme from plasma; Amyloid fiber formation; Scavenging by Class B Receptors; Heme signaling; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Retinoid metabolism and transport; HDL clearance; Defective ABCA1 causes TGD; HDL assembly; Scavenging by Class A Receptors; ABC transporters in lipid homeostasis; Chylomicron assembly; Chylomicron remodeling; HDL remodeling","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Complement system; PPAR-alpha pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Statin inhibition of cholesterol production; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5",373.2,385.1,395.8,335.9,388.3,191,1.2610358391608392,0.3346092782393817,0.25088191849472247,0.6005306379318569,0.49213525020878324,0.30791552660810784,3726]
["P02649","Apolipoprotein E [OS=Homo sapiens]",5,2,4,2,317,36.1,5.73,10.12,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;cytoskeletal activity;other molecular function","APOE","ENSG00000130203","Cholesterol metabolism; Alzheimer disease","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Amyloid fiber formation; Retinoid metabolism and transport; Nuclear signaling by ERBB4; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Chylomicron clearance; Scavenging by Class A Receptors; Chylomicron assembly; Chylomicron remodeling; HDL remodeling; Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors","Vitamin B12 metabolism; Alzheimer's disease and miRNA effects; Apoptosis-related network due to altered Notch3 in ovarian cancer; ApoE and miR-146 in inflammation and atherosclerosis; Statin inhibition of cholesterol production; Familial hyperlipidemia type 3; Alzheimer's disease",400,398.2,421.8,381.4,406.5,448.1,0.9870550161812298,-0.018797595454125876,0.810958247713003,0.09100150491908574,0.8737166616353683,0.05862938228377018,6784]
["P02656","Apolipoprotein C-III [OS=Homo sapiens]",16,1,2,1,99,10.8,5.41,10.27,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","non-structural extracellular;other cytoplasmic organelle","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","APOC3","ENSG00000110245","PPAR signaling pathway; Cholesterol metabolism","Retinoid metabolism and transport; Chylomicron assembly; Chylomicron remodeling; HDL remodeling","PPAR-alpha pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Statin inhibition of cholesterol production",79.1,80.9,76.7,70.3,76.5,148.2,0.8023728813559322,-0.31765524840195125,0.48081568602163993,0.3180213724497476,0.632975837379713,0.19861286801257313,5552]
["P02671-1","Fibrinogen alpha chain [OS=Homo sapiens]",1,1,1,1,866,94.9,6.01,2.72,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGA","ENSG00000171560","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Coronavirus disease","ER-Phagosome pathway; Signaling by BRAF and RAF1 fusions; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Amyloid fiber formation; Integrin cell surface interactions; Platelet degranulation ; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Common Pathway of Fibrin Clot Formation; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway",198.1,151.3,181.2,152.1,110.1,101.3,1.4596973865199447,0.5456693114217389,0.055393880602477207,1.2565382094117479,0.2560872064032295,0.591612117459984,1581]
["P02675","Fibrinogen beta chain [OS=Homo sapiens]",7,4,12,4,491,55.9,8.27,24.85,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGB","ENSG00000171564","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Coronavirus disease","ER-Phagosome pathway; Platelet degranulation ; Common Pathway of Fibrin Clot Formation; Integrin cell surface interactions; Signaling by BRAF and RAF1 fusions; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway; Complement and coagulation cascades",1660.6,1609,2331.5,1798.2,1322.1,1446.4,1.2265092955525871,0.2945581679328577,0.2750626906754924,0.560568313036727,0.5096155148662038,0.2927573586981932,3945]
["P02679","Fibrinogen gamma chain [OS=Homo sapiens]",2,1,2,1,453,51.5,5.62,5.09,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGG","ENSG00000171557","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Staphylococcus aureus infection; Coronavirus disease","ER-Phagosome pathway; Platelet degranulation ; Integrin cell surface interactions; Signaling by BRAF and RAF1 fusions; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Common Pathway of Fibrin Clot Formation; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway",158.4,152.8,279.9,196.3,118.6,109,1.3944326492097194,0.47967825419579563,0.32601893250341346,0.486757178941217,0.5395997232036797,0.26792828177838646,4416]
["P02686-1","myelin basic protein [OS=Homo sapiens]",3,1,1,1,304,33.1,9.79,2,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","MBP","ENSG00000197971; ENSGGOG00000009590","","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Neural crest differentiation; Glial cell differentiation; Spinal cord injury; Interleukin-1 (IL-1) structural pathway; MECP2 and associated Rett syndrome; MAPK cascade; Complement system in neuronal development and plasticity",24.9,23.1,33.8,36.9,28.5,66.2,0.6215805471124619,-0.685986740793493,0.2353706368575991,0.6282477175593741,0.4776024388651282,0.3209334641589157,3602]
["P02749","Beta-2-glycoprotein 1 [OS=Homo sapiens]",4,2,5,2,345,38.3,7.97,7.37,"protein metabolism;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;other cell component","enzyme regulator activity;other molecular function","APOH","ENSG00000091583","Cholesterol metabolism","Platelet degranulation","",656.4,626.4,662.8,494.6,717.9,548.3,1.1049522944116312,0.1439840835520284,0.4176202337620509,0.3792184678642049,0.5866589061247031,0.2316143318762685,5203]
["P02751","fibronectin [OS=Homo sapiens]",12,20,36,20,2386,262.5,5.71,113.49,"","","","","","","","",2582.6,2529.5,3445.3,2711.6,2191.2,2600,1.1405608572799493,0.1897434270565357,0.35493263710605416,0.4498540641537633,0.5553848521961358,0.255405969557573,4671]
["P02753","Retinol-binding protein 4 [OS=Homo sapiens]",4,1,1,1,201,23,6.07,1.83,"other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;other cell component","transporter activity;other molecular function","RBP4","ENSG00000138207","","Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision); Retinoid cycle disease events; Retinoid metabolism disease events","Sterol regulatory element-binding proteins (SREBP) signaling; Vitamin A and carotenoid metabolism",144.1,177.5,189.9,127,195.8,188,1.0013703993735317,1.9757149299671263E-3,0.9931888933752551,2.9681457151470333E-3,0.99536783514051,2.01639739417225E-3,7293]
["P02760","Protein AMBP [OS=Homo sapiens]",2,1,2,1,352,39,6.25,1.84,"cell adhesion;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","enzyme regulator activity;other molecular function","AMBP","ENSG00000106927","","Scavenging of heme from plasma","",408.9,435.2,430.2,404.6,452.5,286.5,1.11428821266177,0.15612243662688893,0.43259794567335774,0.36391554727520553,0.5988368153270023,0.2226915079250448,5280]
["P02765","Alpha-2-HS-glycoprotein [OS=Homo sapiens]",5,3,23,3,367,39.3,5.72,66.88,"","","","","","","","",4226.8,4372.4,4576.3,3233.2,5121.5,1528.1,1.3331748087586512,0.4148659621180063,0.35190510847160067,0.4535744286324869,0.5546850200170216,0.2559535626443184,4637]
["P02766","Transthyretin [OS=Homo sapiens]",4,1,2,1,147,15.9,5.76,2.01,"other metabolic processes;transport;signal transduction","non-structural extracellular;other cytoplasmic organelle","signal transduction activity or receptor binding;other molecular function","TTR","ENSG00000118271","Thyroid hormone synthesis","Neutrophil degranulation; Amyloid fiber formation; Retinoid metabolism and transport; Non-integrin membrane-ECM interactions; The canonical retinoid cycle in rods (twilight vision); Retinoid cycle disease events","",145.5,156.8,141.9,147.9,165.1,106.3,1.0593846887669927,0.08322656270059098,0.6690540089760022,0.17453882266043105,0.7690070375225035,0.11406968576007159,6359]
["P02768-1","Serum albumin [OS=Homo sapiens]",12,9,57,9,609,69.3,6.28,144.76,"stress response;other biological processes","non-structural extracellular;ER/Golgi;other cell component","nucleic acid binding activity;other molecular function","ALB","ENSG00000163631","Thyroid hormone synthesis","Cytoprotection by HMOX1; Scavenging of heme from plasma; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Recycling of bile acids and salts; Heme degradation; HDL remodeling; Heme biosynthesis","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Complement system; VEGFA-VEGFR2 signaling pathway",10728.6,10414.2,11184.2,9218.8,11913.2,8098.5,1.1059338704435437,0.14526512188774326,0.4216068939889239,0.3750922962849093,0.5899913437038187,0.22915436023793,5223]
["P02771","Alpha-fetoprotein [OS=Homo sapiens]",3,2,5,2,609,68.6,5.68,14.64,"other metabolic processes;developmental processes;signal transduction","non-structural extracellular;ER/Golgi;other cell component","other molecular function","AFP","ENSG00000081051","Hippo signaling pathway","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",1073.6,1078.3,1142.3,1049.3,1271.3,2405.2,0.6970671632316222,-0.5206304267520321,0.3198048064540792,0.4951150133827866,0.5370986512805296,0.26994593818893714,4352]
["P02774","vitamin D-binding protein [OS=Homo sapiens]",8,2,7,2,474,52.9,5.54,29.89,"transport","non-structural extracellular","transporter activity;cytoskeletal activity;other molecular function","HEL-S-51","","","","",446.4,403,448.7,380,450.5,1837.1,0.48661718398560505,-1.0391408276050988,0.39060573684763744,0.40826138249471816,0.573626146397304,0.24137106135476832,4977]
["P02786","Transferrin receptor protein 1 [OS=Homo sapiens]",34,25,82,25,760,84.8,6.61,240.32,"protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","TFRC","ENSG00000072274","HIF-1 signaling pathway; Endocytosis; Phagosome; Ferroptosis; Hematopoietic cell lineage","RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; RHOC GTPase cycle; RND2 GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RND1 GTPase cycle; Transferrin endocytosis and recycling; RHOH GTPase cycle","Iron metabolism in placenta; Ferroptosis; 3q29 copy number variation syndrome",9405.1,9505.3,9581.2,9305.5,8895.7,9027,1.0464004230907662,0.06543502927320008,0.032546443921655656,1.4874964562377289,0.2022805770606983,0.6940458160938755,1176]
["P02787","Serotransferrin [OS=Homo sapiens]",2,1,2,1,698,77,7.12,2.06,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","TF","ENSG00000091513","HIF-1 signaling pathway; Ferroptosis; Mineral absorption","Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cargo recognition for clathrin-mediated endocytosis; Transferrin endocytosis and recycling","Iron metabolism in placenta; Pluripotent stem cell differentiation pathway; Ferroptosis; IL-18 signaling pathway; 3q29 copy number variation syndrome; Sudden infant death syndrome (SIDS) susceptibility pathways",208.8,194.3,202,147,169.1,386.6,0.8611071581044543,-0.2157353138897229,0.6927604039006142,0.1594169432466351,0.7859959317152421,0.10457970184633474,6442]
["P02788","Lactotransferrin [OS=Homo sapiens]",1,1,1,1,710,78.1,8.12,2.05,"protein metabolism;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","LTF","ENSG00000012223","","Neutrophil degranulation; Amyloid fiber formation; Mtb iron assimilation by chelation; Metal sequestration by antimicrobial proteins","Male infertility",179.1,204.8,219.6,164,183.7,136.2,1.2471585038231041,0.31864483176558517,0.09315521244281032,1.0307928394063255,0.32924151244898486,0.4824854119442575,2068]
["P02792","Ferritin light chain [OS=Homo sapiens]",62,11,90,11,175,20,5.78,266.59,"transport;other biological processes","non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component","other molecular function","FTL","ENSG00000087086","Ferroptosis; Necroptosis; Mineral absorption","Neutrophil degranulation; Scavenging by Class A Receptors; Golgi Associated Vesicle Biogenesis; Iron uptake and transport","Nuclear receptors meta-pathway; NRF2 pathway; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway",19099.3,20082.7,17752.8,10647.9,12880.8,14601.4,1.4931720609177528,0.5783804194109304,0.009191644304499308,2.0366067901924967,0.11196954703597574,0.9509000786921675,600]
["P02794","Ferritin heavy chain [OS=Homo sapiens]",43,5,13,5,183,21.2,5.55,47.17,"transport;other biological processes","non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component","other molecular function","FTH1","ENSG00000167996","Ferroptosis; Necroptosis; Mineral absorption","Neutrophil degranulation; Scavenging by Class A Receptors; Golgi Associated Vesicle Biogenesis; Iron uptake and transport","Iron metabolism in placenta; Nuclear receptors meta-pathway; NRF2 pathway; Ferroptosis",879,859.5,792.9,780.4,734,2290,0.6653874461150248,-0.5877334477805765,0.45363465057885644,0.34329377955509566,0.6124151572000114,0.21295406910561032,5414]
["P03891","NADH-ubiquinone oxidoreductase chain 2 [OS=Homo sapiens]",5,2,8,2,347,38.9,9.83,14.21,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;other cell component","signal transduction activity or receptor binding;transporter activity;other molecular function","MT-ND2","ENSG00000198763","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",760.9,774.4,762.2,654.9,639.3,481.9,1.2935645515455212,0.37135204928428656,0.034975872491982016,1.4562314429911858,0.20749890587978614,0.6829841889356194,1232]
["P03897","NADH-ubiquinone oxidoreductase chain 3 [OS=Homo sapiens]",13,1,4,1,115,13.2,4.44,10.89,"other metabolic processes;stress response;transport;other biological processes","other membranes;mitochondrion","transporter activity","MT-ND3","ENSG00000198840","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",104.4,113,148.3,124,134.2,832.5,0.33528926377555707,-1.5765218072395468,0.36165532819072016,0.44170513215187174,0.5579018137918897,0.25344222665464505,4738]
["P03905","NADH-ubiquinone oxidoreductase chain 4 [OS=Homo sapiens]",7,3,13,3,459,51.5,9.35,35.17,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MT-ND4","ENSG00000198886","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",1139.3,1255.2,1287.7,1037.2,961,785.8,1.3226293103448274,0.4034087781225758,0.02625241280924308,1.580830775245269,0.185211279172546,0.7323325687705103,1036]
["P03923","NADH-ubiquinone oxidoreductase chain 6 [OS=Homo sapiens]",8,1,2,1,174,18.6,4.22,9.21,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","other membranes;mitochondrion","transporter activity","MT-ND6","ENSG00000198695","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",173.3,182.5,207.8,154,154.7,186.6,1.1378962245103978,0.18636899067522256,0.20122629341431378,0.6963152724298682,0.44826668045267276,0.34846354093194293,3281]
["P03928","ATP synthase protein 8 [OS=Homo sapiens]",13,1,2,1,68,8,9.91,5.52,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","MT-ATP8","ENSG00000228253","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome",790.9,1119.2,1292,605.9,1450.1,69.7,1.5063743707955026,0.591080359498679,0.4488416029995029,0.3479068952551656,0.6102275439589595,0.2145081934169615,5376]
["P04004","Vitronectin [OS=Homo sapiens]",9,2,18,2,478,54.3,5.8,74.16,"cell adhesion;transport;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;extracellular structural activity;other molecular function","VTN","ENSG00000109072","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Complement and coagulation cascades; Human papillomavirus infection; Proteoglycans in cancer","Regulation of Complement cascade; Integrin cell surface interactions; ECM proteoglycans; Syndecan interactions; Molecules associated with elastic fibres","Primary focal segmental glomerulosclerosis (FSGS); Complement system; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; Inflammatory response pathway; Complement system in neuronal development and plasticity; Senescence and autophagy in cancer",1235.4,1165.8,1220.6,1039.9,1138.2,1014.6,1.1344003508002631,0.18192988382698644,0.029701491992059573,1.5272217342638081,0.19610497287259568,0.707511393258558,1107]
["P04040","catalase [OS=Homo sapiens]",49,20,80,20,527,59.7,7.39,257.61,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CAT","ENSG00000121691","Tryptophan metabolism; Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism; FoxO signaling pathway; Peroxisome; Longevity regulating pathway; Longevity regulating pathway; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Chemical carcinogenesis","Neutrophil degranulation; Peroxisomal protein import; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Detoxification of Reactive Oxygen Species","Selenium micronutrient network; Folate metabolism; Amyotrophic lateral sclerosis (ALS); Oxidative stress response; Tryptophan metabolism; Male infertility; DNA damage response (only ATM dependent)",7322.5,7297.8,7364.5,6944.4,6996.2,5750.6,1.1164784269115138,0.1589553750399532,0.13373739451237301,0.873747142029804,0.38078948830967446,0.4193150488172744,2567]
["P04049","RAF proto-oncogene serine/threonine-protein kinase [OS=Homo sapiens]",18,10,19,7,648,73,9.2,53.28,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","RAF1","ENSG00000132155","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Cellular senescence; Vascular smooth muscle contraction; Axon guidance; VEGF signaling pathway; Apelin signaling pathway; Focal adhesion; Gap junction; Signaling pathways regulating pluripotency of stem cells; Neutrophil extracellular trap formation; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Long-term potentiation; Neurotrophin signaling pathway; Serotonergic synapse; Long-term depression; Regulation of actin cytoskeleton; Insulin signaling pathway; GnRH signaling pathway; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Melanogenesis; Prolactin signaling pathway; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Relaxin signaling pathway; Parathyroid hormone synthesis, secretion and action; GnRH secretion; Growth hormone synthesis, secretion and action; Alzheimer disease; Pathways of neurodegeneration; Alcoholism; Salmonella infection; Tuberculosis; Hepatitis C; Hepatitis B; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer","Signaling by BRAF and RAF1 fusions; Stimuli-sensing channels; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; CD209 (DC-SIGN) signaling; Rap1 signalling; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GP1b-IX-V activation signalling; Negative feedback regulation of MAPK pathway","IL-5 signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Endothelin pathways; Pilocytic astrocytoma; Glioblastoma signaling pathways; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Retinoblastoma gene in cancer; Aryl hydrocarbon receptor Netpath; Common pathways underlying drug addiction; Cardiac hypertrophic response; Bladder cancer; IL-3 signaling pathway; Extracellular vesicle-mediated signaling in recipient cells; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; Pathways affected in adenoid cystic carcinoma; TGF-beta signaling pathway; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; ERK pathway in Huntington's disease; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway; Fragile X syndrome; 22q11.2 copy number variation syndrome; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; Netrin-UNC5B signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Regucalcin in proximal tubule epithelial kidney cells; Kisspeptin/kisspeptin receptor system in the ovary; CAMKK2 pathway; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Angiotensin II receptor type 1 pathway; Malignant pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; EPO receptor signaling; Senescence and autophagy in cancer; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling",1653.8,1640.3,1644,1874.2,1826.1,2988.4,0.7382750011212941,-0.4377697869308064,0.19913922911272466,0.7008431784005708,0.44674911773631204,0.3499362964890884,3258]
["P04053","DNA nucleotidylexotransferase [OS=Homo sapiens]",3,1,1,1,509,58.5,8.43,2.25,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DNTT","ENSG00000107447","Non-homologous end-joining; Hematopoietic cell lineage","","",21,13.8,20.5,7.4,8.3,10.3,2.126923076923077,1.0887678572062525,0.01685721691977702,1.7732141246194983,0.1504388259666059,0.8226400644959438,819]
["P04062","glucosylceramidase [OS=Homo sapiens]",21,10,25,10,536,59.7,7.61,73.39,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","signal transduction activity or receptor binding;other molecular function","GBA","ENSG00000177628","Other glycan degradation; Sphingolipid metabolism; Metabolic pathways; Lysosome","Glycosphingolipid metabolism; Association of TriC/CCT with target proteins during biosynthesis","Sphingolipid pathway",3242.1,3251.5,3315.4,2972.1,3108.7,4172.5,0.9566676094525666,-0.06391034205865419,0.7166765182575917,0.1446768248568431,0.8036496888531356,0.09493321910199552,6518]
["P04066","tissue alpha-L-fucosidase [OS=Homo sapiens]",21,9,25,9,466,53.7,6.84,71.08,"other metabolic processes","non-structural extracellular;other cytoplasmic organelle;other cell component","other molecular function","FUCA1","ENSG00000179163","Other glycan degradation; Lysosome","Neutrophil degranulation; Reactions specific to the complex N-glycan synthesis pathway","p53 transcriptional gene network",3392.8,3303.9,3349.5,2821,2693.4,2298.4,1.2858642228138442,0.3627383134164565,0.009512529276892615,2.0217039935829115,0.11268569932707961,0.9481311957321802,617]
["P04075","fructose-bisphosphate aldolase A [OS=Homo sapiens]",77,29,534,21,364,39.4,8.09,1806.83,"cell organization and biogenesis;other metabolic processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ALDOA","ENSG00000149925","Glycolysis / Gluconeogenesis; Pentose phosphate pathway; Fructose and mannose metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; HIF-1 signaling pathway","Neutrophil degranulation; Glycolysis; Platelet degranulation ; Gluconeogenesis","VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; 16p11.2 proximal deletion syndrome; Glycolysis and gluconeogenesis; Sudden infant death syndrome (SIDS) susceptibility pathways",60679.7,57995.1,59631,59033.5,57098.5,60892.3,{"$f":"AVERAGE(S962:U962)/AVERAGE(V962:X962)","v":1.007239119149179},{"$f":"LOG(Y962,2)","v":0.010406220642323338},{"$f":"TTEST(S962:U962,V962:X962,2,2)","v":0.7667235467653114},{"$f":"-LOG10(AA962)","v":0.11536119896730607},{"$f":"AA962*7309/AE962","v":0.8405553327295127},{"$f":"-LOG10(AC962)","v":0.07543369220889704},6667]
["P04080","Cystatin-B [OS=Homo sapiens]",52,4,24,4,98,11.1,7.56,83.31,"other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","CSTB","ENSG00000160213","","Neutrophil degranulation","",3639.2,3793,3259.2,3610.7,3643.5,3212.9,1.021429049115801,0.030588994532423155,0.7404107015735437,0.13052731277063254,0.8224410057448376,0.08489524450061503,6580]
["P04114","apolipoprotein B-100 [OS=Homo sapiens]",1,2,2,2,4563,515.3,7.05,5.51,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;other molecular function","APOB","ENSG00000084674","Fat digestion and absorption; Vitamin digestion and absorption; Cholesterol metabolism; Lipid and atherosclerosis","Heme signaling; Cell surface interactions at the vascular wall; Scavenging by Class B Receptors; Regulation of TLR by endogenous ligand; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Retinoid metabolism and transport; Cargo recognition for clathrin-mediated endocytosis; LDL clearance; Chylomicron clearance; Scavenging by Class A Receptors; Chylomicron assembly; Chylomicron remodeling; VLDL assembly; VLDL clearance; Scavenging by Class F Receptors; Scavenging by Class H Receptors; Platelet sensitization by LDL; LDL remodeling","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Statin inhibition of cholesterol production; Male infertility; Familial hyperlipidemia type 2",176.2,181.2,221.6,201.1,184.1,460.9,0.6843162746720246,-0.5472648363815338,0.3819276166839916,0.4180189372280737,0.5680726394675,0.2455961274881628,4914]
["P04150","Glucocorticoid receptor [OS=Homo sapiens]",27,15,26,15,777,85.6,6.38,70.1,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","NR3C1","ENSG00000113580","Neuroactive ligand-receptor interaction","Potential therapeutics for SARS; Regulation of RUNX2 expression and activity; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Circadian Clock; SUMOylation of intracellular receptors; PTK6 Expression","Nuclear receptors; Adipogenesis; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Endoderm differentiation; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Transcription factor regulation in adipogenesis; White fat cell differentiation; Vitamin D in inflammatory diseases; 16p11.2 proximal deletion syndrome; Sudden infant death syndrome (SIDS) susceptibility pathways; Serotonin receptor 4/6/7 and NR3C signaling",1811.3,1768.5,1799.8,1932.4,1955.2,1829.2,0.9410159529806884,-0.08770891381342578,0.051179949893299485,1.2909001436359024,0.2478954630683406,0.6057314215275192,1509]
["P04156-1","Major prion protein [OS=Homo sapiens]",20,5,16,5,253,27.6,9,32.24,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function","PRNP","ENSG00000171867","Ferroptosis; Prion disease; Pathways of neurodegeneration","NCAM1 interactions; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","Complement system; Copper homeostasis; Prion disease pathway; Ferroptosis",1337.4,1396.6,1370.2,1452.4,1590.8,1661.7,0.8723245977597823,-0.1970630236012505,0.03489779821313566,1.4572019728703365,0.20771010353404606,0.6825423777915123,1228]
["P04179","Superoxide dismutase [Mn], mitochondrial [OS=Homo sapiens]",39,7,31,7,222,24.7,8.25,102.06,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","mitochondrion","other molecular function","SOD2","ENSPPAG00000038347","FoxO signaling pathway; Peroxisome; Longevity regulating pathway; Longevity regulating pathway; Huntington disease; Chemical carcinogenesis; Lipid and atherosclerosis","","",4373.9,4557.3,4448.5,3830.3,3969.7,4373,1.0991292204058163,0.13636100837954604,0.07857306948043827,1.1047262806799985,0.30531130506779547,0.5152571143464044,1881]
["P04181-1","Ornithine aminotransferase, mitochondrial [OS=Homo sapiens]",51,15,92,15,439,48.5,7.03,291.77,"other metabolic processes;other biological processes","mitochondrion;nucleus;other cell component","other molecular function","OAT","ENSG00000065154; ENSPPAG00000034558; ENSPTRG00000003028","Arginine and proline metabolism; Metabolic pathways","Glutamate and glutamine metabolism","Amino acid metabolism; 22q11.2 copy number variation syndrome",9503.6,9803.3,9569.8,8646.5,7964.1,6560.2,1.246253905777962,0.31759802605790793,0.03752883907151562,1.4256348699762826,0.21197703614660562,0.6737111844249913,1294]
["P04183","Thymidine kinase, cytosolic [OS=Homo sapiens]",43,9,38,9,234,25.5,8.51,104.68,"cell organization and biogenesis;DNA metabolism;other metabolic processes","cytosol","kinase activity;other molecular function","TK1","ENSG00000167900","Pyrimidine metabolism; Drug metabolism; Metabolic pathways","Pyrimidine salvage; G1/S-Specific Transcription","Fluoropyrimidine activity; Pyrimidine metabolism",3034.2,3106.9,3101.4,2661.7,2327.1,1782.2,1.365012553537144,0.44891421916161356,0.03286695559755464,1.4832405219121607,0.20306388711963386,0.6923673046561181,1183]
["P04233-2","Isoform 2 of HLA class II histocompatibility antigen gamma chain [OS=Homo sapiens]",48,10,116,10,232,26.4,9.14,330.43,"","","","CD74","","","","",14517.7,15190.7,14823.5,12989.7,15204.5,13950.3,1.0566479611811743,0.07949480032174029,0.30069237768863805,0.5218775807778349,0.5262836658348313,0.27878010888806765,4176]
["P04259","keratin, type II cytoskeletal 6B [OS=Homo sapiens]",31,21,79,2,564,60,8,188.7,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","cytoskeletal activity","KRT6B","ENSG00000185479","","Formation of the cornified envelope","",287.4,249.6,246.2,194.8,259.3,578.2,0.7586941780490166,-0.3984096278544426,0.5245998634802366,0.2801718267647038,0.6647538838725813,0.17733911659210352,5768]
["P04264","Keratin, type II cytoskeletal 1 [OS=Homo sapiens]",52,37,272,31,644,66,8.12,762.82,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","bone, tooth or skin structural activity;other molecular function","KRT1","ENSG00000167768","","Neutrophil degranulation; Formation of the cornified envelope","Corticotropin-releasing hormone signaling pathway",32414.8,44895.9,32501.9,27217.1,41089.7,33969.5,1.073685692579806,0.10257172505452584,0.6854787993496502,0.16400597262916058,0.7805210382375125,0.10761538642946555,6419]
["P04406-1","glyceraldehyde-3-phosphate dehydrogenase [OS=Homo sapiens]",79,22,1504,22,335,36,8.46,5838.71,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","GAPDH; HEL-S-162eP; LOC117800120","ENSAMEG00000025937; ENSG00000111640; ENSGGOG00000009553; ENSPPAG00000039909; ENSPTRG00000004577","Glycolysis / Gluconeogenesis; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; HIF-1 signaling pathway; Alzheimer disease; Pathogenic Escherichia coli infection; Salmonella infection; Diabetic cardiomyopathy","Glycolysis; Gluconeogenesis","Cori cycle; Alzheimer's disease and miRNA effects; HIF1A and PPARG regulation of glycolysis; VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; 7q11.23 copy number variation syndrome; Glycolysis in senescence; Alzheimer's disease; Glycolysis and gluconeogenesis; Sudden infant death syndrome (SIDS) susceptibility pathways",135650.8,134443.3,134630.4,125776.7,120659.5,111905.4,1.1294376650659594,0.17560464896752145,0.01908198036316445,1.7193765554095133,0.15921255076982757,0.798022699693621,876]
["P04424","argininosuccinate lyase [OS=Homo sapiens]",19,8,21,8,464,51.6,6.48,62.06,"other metabolic processes","cytosol;other cell component","other molecular function","ASL","ENSG00000126522","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Metabolic pathways; Biosynthesis of amino acids","Urea cycle","Alanine and aspartate metabolism",2044.6,2023.7,1941.5,1753.1,1764.7,2077.2,1.0741376228775692,0.10317884911760901,0.2798306940195111,0.5531046504153431,0.5140192366395091,0.28902062767775843,3979]
["P04632","Calpain small subunit 1 [OS=Homo sapiens]",77,12,90,12,268,28.3,5.2,324.41,"protein metabolism;other biological processes","plasma membrane;other membranes;cytosol","other molecular function","CAPNS1","ENSG00000126247","Shigellosis","Formation of the cornified envelope; Degradation of the extracellular matrix; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models","Integrin-mediated cell adhesion",8675.7,8231.7,8108,8200,8346.5,5359.8,1.1419272081547318,0.19147068942121392,0.3530615473130731,0.45214957980059184,0.5548326917461301,0.25583795742813537,4651]
["P04637","Cellular tumor antigen p53 [OS=Homo sapiens]",6,3,3,3,393,43.6,6.79,7.18,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function","TP53","ENSG00000141510","Endocrine resistance; Platinum drug resistance; MAPK signaling pathway; Sphingolipid signaling pathway; Cell cycle; p53 signaling pathway; Mitophagy; PI3K-Akt signaling pathway; Apoptosis; Longevity regulating pathway; Ferroptosis; Cellular senescence; Wnt signaling pathway; Neurotrophin signaling pathway; Thyroid hormone signaling pathway; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Shigellosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Pathways in cancer; Transcriptional misregulation in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Colorectal cancer; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Thyroid cancer; Basal cell carcinoma; Melanoma; Bladder cancer; Chronic myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","TP53 Regulates Transcription of DNA Repair Genes; Autodegradation of the E3 ubiquitin ligase COP1; Ub-specific processing proteases; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of PTEN gene transcription; Factors involved in megakaryocyte development and platelet production; Interleukin-4 and Interleukin-13 signaling; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; TP53 Regulates Transcription of Death Receptors and Ligands; Oxidative Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Association of TriC/CCT with target proteins during biosynthesis; Pre-NOTCH Transcription and Translation; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; TP53 Regulates Transcription of Caspase Activators and Caspases; Regulation of TP53 Activity through Methylation; G2/M DNA damage checkpoint; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Activation of PUMA and translocation to mitochondria; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; Regulation of TP53 Activity through Association with Co-factors; Ovarian tumor domain proteases; Pyroptosis; SUMOylation of transcription factors; Regulation of TP53 Expression; RUNX3 regulates CDKN1A transcription; Activation of NOXA and translocation to mitochondria; Formation of Senescence-Associated Heterochromatin Foci (SAHF); PI5P Regulates TP53 Acetylation; Transcriptional  activation of  cell cycle inhibitor p21 ; Loss of function of TP53 in cancer due to loss of tetramerization ability","AMP-activated protein kinase (AMPK) signaling; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Fluoropyrimidine activity; TP53 network; Folate metabolism; Apoptosis modulation and signaling; Cell cycle; Metastatic brain tumor; Glioblastoma signaling pathways; Gastric cancer network 2; Oncostatin M signaling pathway; Spinal cord injury; Retinoblastoma gene in cancer; Amyotrophic lateral sclerosis (ALS); ATM signaling pathway; Apoptosis; Mammary gland development pathway - Involution (Stage 4 of 4); Bladder cancer; Copper homeostasis; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced HIF-1 survival signaling; Hepatitis C and hepatocellular carcinoma; Pathways affected in adenoid cystic carcinoma; TGF-beta signaling pathway; lncRNA-mediated mechanisms of therapeutic resistance; MAPK signaling pathway; miRNA regulation of p53 pathway in prostate cancer; Wnt signaling pathway and pluripotency; Endometrial cancer; PI3K-Akt signaling pathway; Caloric restriction and aging; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer; Ferroptosis; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; MicroRNA network associated with chronic lymphocytic leukemia; G1 to S cell cycle control; 22q11.2 copy number variation syndrome; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Unfolded protein response; 16p11.2 proximal deletion syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis in senescence; TCA cycle in senescence; Malignant pleural mesothelioma; Senescence and autophagy in cancer; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)",324,310.3,318,230.8,246.5,335.4,1.17177310200566,0.2286932384443741,0.2290684935343765,0.6400346402960613,0.47268820419050195,0.3254252352661443,3542]
["P04792","Heat shock protein beta-1 [OS=Homo sapiens]",29,5,7,5,205,22.8,6.4,25.69,"stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","HSPB1","ENSG00000106211","MAPK signaling pathway; VEGF signaling pathway; Amoebiasis","AUF1 (hnRNP D0) binds and destabilizes mRNA; MAPK6/MAPK4 signaling; Extra-nuclear estrogen signaling; VEGFA-VEGFR2 Pathway","Apoptosis-related network due to altered Notch3 in ovarian cancer; Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; ATM signaling in development and disease ; VEGFA-VEGFR2 signaling pathway; p38 MAPK signaling pathway; Extracellular vesicles in the crosstalk of cardiac cells; Ferroptosis; IL-18 signaling pathway; Intracellular trafficking proteins involved in CMT neuropathy",925.8,931,911.7,783.3,757.3,814.9,1.175334323922734,0.2330711898624748,1.4494317982706418E-3,2.8388022151703622,0.043240395973714776,1.364110337650922,245]
["P04818","thymidylate synthase [OS=Homo sapiens]",15,5,6,5,313,35.7,7.01,3.92,"DNA metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","TYMS","ENSG00000176890","Pyrimidine metabolism; One carbon pool by folate; Metabolic pathways; Antifolate resistance","Interconversion of nucleotide di- and triphosphates; G1/S-Specific Transcription","Fluoropyrimidine activity; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration and one-carbon metabolism; One-carbon metabolism and related pathways; Ethanol effects on histone modifications; Pyrimidine metabolism",285.9,304.9,279.5,583.7,632.5,590.8,0.48162700608743764,-1.0540118048328087,5.2013212044084018E-5,4.283886325807026,0.011520138388794246,1.9385423038009402,33]
["P04839","Cytochrome b-245 heavy chain [OS=Homo sapiens]",4,2,4,2,570,65.3,8.63,5.85,"other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","CYBB","ENSG00000165168","HIF-1 signaling pathway; Phagosome; Ferroptosis; Necroptosis; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Leukocyte transendothelial migration; AGE-RAGE signaling pathway in diabetic complications; Alzheimer disease; Prion disease; Pathways of neurodegeneration; Leishmaniasis; Coronavirus disease; Diabetic cardiomyopathy; Lipid and atherosclerosis","Neutrophil degranulation; RAC2 GTPase cycle; RAC3 GTPase cycle; RAC1 GTPase cycle; Detoxification of Reactive Oxygen Species; VEGFA-VEGFR2 Pathway; ROS and RNS production in phagocytes; Cross-presentation of particulate exogenous antigens (phagosomes); RHO GTPases Activate NADPH Oxidases","Alzheimer's disease and miRNA effects; VEGFA-VEGFR2 signaling pathway; Microglia pathogen phagocytosis pathway; Oxidative stress response; Ferroptosis; Alzheimer's disease; Type II interferon signaling (IFNG)",533.1,510.7,582.7,525.6,510.7,422.4,1.115033934325084,0.15708761699539492,0.2208810619248721,0.6558415184160428,0.46471493425702076,0.33281337064314964,3474]
["P04843","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [OS=Homo sapiens]",63,36,375,36,607,68.5,6.38,1108.82,"protein metabolism;other metabolic processes","other membranes;cytosol;ER/Golgi;other cell component","","RPN1","ENSG00000163902","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum","SRP-dependent cotranslational protein targeting to membrane; Asparagine N-linked glycosylation; Maturation of spike protein","Proteasome degradation",43316.8,44164.2,44061.6,41985.2,41427.5,36981.5,1.0925991451415433,0.12776419937265399,0.08161866837666501,1.0882104950979599,0.3094143398158945,0.5094595627807988,1928]
["P04844-1","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [OS=Homo sapiens]",52,22,187,1,631,69.2,5.69,634.88,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus;other cytoplasmic organelle","translation activity","RPN2","ENSG00000118705","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum","SRP-dependent cotranslational protein targeting to membrane; Asparagine N-linked glycosylation; Maturation of spike protein","Proteasome degradation",488.8,521.7,510.8,395.3,382.7,127.3,1.680437424058323,0.7488368207288685,0.07959698096882592,1.0991034042905288,0.30668125139754804,0.5133127732952183,1897]
["P04844-2","Isoform 2 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [OS=Homo sapiens]",49,22,161,1,615,67.7,6.06,563.89,"","","","RPN2","","","","",12761.6,13184.7,13438.4,11247,10539,9175.7,1.272045785599628,0.3471505994498929,0.011752266154284,1.9298783816129679,0.12485074610706651,0.9036088579645062,688]
["P04899-1","guanine nucleotide-binding protein G(i) subunit alpha-2 [OS=Homo sapiens]",60,16,67,9,355,40.4,5.54,231.53,"cell-cell signaling;cell cycle OR cell proliferation;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","GNAI2","ENSCANG00000029469; ENSCATG00000043630; ENSCSAG00000014329; ENSG00000114353; ENSMFAG00000032665; ENSMMUG00000056280; ENSMNEG00000033996; ENSNLEG00000006962; ENSPANG00000023235; ENSPTRG00000014951; ENSRBIG00000038900; ENSRROG00000029350; ENSTSYG00000005938","Rap1 signaling pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Adrenergic signaling in cardiomyocytes; Axon guidance; Apelin signaling pathway; Gap junction; Platelet activation; Leukocyte transendothelial migration; Circadian entrainment; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; GABAergic synapse; Dopaminergic synapse; Long-term depression; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Melanogenesis; Oxytocin signaling pathway; Regulation of lipolysis in adipocytes; Renin secretion; Relaxin signaling pathway; Parathyroid hormone synthesis, secretion and action; Cushing syndrome; Growth hormone synthesis, secretion and action; Gastric acid secretion; Parkinson disease; Cocaine addiction; Morphine addiction; Alcoholism; Pertussis; Chagas disease; Toxoplasmosis; Human cytomegalovirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Chemical carcinogenesis","G alpha (i) signalling events; G alpha (z) signalling events; Adenylate cyclase inhibitory pathway; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; ADORA2B mediated anti-inflammatory cytokines production; Adrenaline,noradrenaline inhibits insulin secretion","Thyroid stimulating hormone (TSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; S1P receptor signal transduction; Complement system; G protein signaling pathways; Chemokine signaling pathway; Hippo signaling regulation pathways; Purinergic signaling; Calcium regulation in cardiac cells; Calcium regulation in cardiac cells",7955.8,8196.2,8196.5,7375.3,6896.3,7728.2,1.1067600614551043,0.1463424889048574,0.03687238023542023,1.433298826328172,0.2105470524536613,0.6766508340920676,1280]
["P04920-1","Anion exchange protein 2 [OS=Homo sapiens]",26,23,59,23,1241,136.9,6.29,248.64,"transport;developmental processes;other biological processes","plasma membrane;other membranes","transporter activity;other molecular function","SLC4A2","ENSG00000164889","Salivary secretion; Gastric acid secretion; Pancreatic secretion; Bile secretion","Bicarbonate transporters","Proximal tubule transport",3978.7,4150.9,4126.1,3627.6,3698.9,4072.9,1.0751179886660702,0.1044949968590176,0.1263629701857144,0.8983801744722876,0.37017512989474416,0.43159276254772333,2495]
["P04921-1","Glycophorin-C [OS=Homo sapiens]",27,2,4,2,128,13.8,4.84,19.82,"","plasma membrane;other membranes;cytoskeleton","","GYPC","ENSG00000136732","Malaria","Cell surface interactions at the vascular wall","",367.2,428.4,371.6,441.9,473,758.7,0.6974187380497131,-0.5199029683290507,0.17568302551988457,0.7552701979763792,0.42645872916799615,0.37012299160516554,3011]
["P05023","Sodium/potassium-transporting ATPase subunit alpha-1 [OS=Homo sapiens]",46,42,245,42,1023,112.8,5.49,823.18,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;cytoskeletal activity;other molecular function","ATP1A1","ENSG00000163399","cGMP-PKG signaling pathway; cAMP signaling pathway; Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Insulin secretion; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Aldosterone synthesis and secretion; Aldosterone-regulated sodium reabsorption; Endocrine and other factor-regulated calcium reabsorption; Proximal tubule bicarbonate reclamation; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Carbohydrate digestion and absorption; Protein digestion and absorption; Bile secretion; Mineral absorption","Ion homeostasis; Ion transport by P-type ATPases; Potential therapeutics for SARS","Pre-implantation embryo; Proximal tubule transport",25105.8,25694.5,25312,20977.8,21878.1,23742.2,1.1428599314394856,0.19264859812777865,0.018917877617897105,1.7231275883643755,0.15874944604960958,0.7992877814880658,871]
["P05026","Sodium/potassium-transporting ATPase subunit beta-1 [OS=Homo sapiens]",8,3,5,3,303,35,8.53,5.59,"cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","transporter activity;other molecular function","ATP1B1","ENSG00000143153","cGMP-PKG signaling pathway; cAMP signaling pathway; Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Insulin secretion; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Aldosterone synthesis and secretion; Aldosterone-regulated sodium reabsorption; Endocrine and other factor-regulated calcium reabsorption; Proximal tubule bicarbonate reclamation; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Carbohydrate digestion and absorption; Protein digestion and absorption; Bile secretion; Mineral absorption","Ion homeostasis; Ion transport by P-type ATPases; Potential therapeutics for SARS; Basigin interactions","Proximal tubule transport; Calcium regulation in cardiac cells",602.9,640.6,600.2,505,511.5,626.3,1.122291210129048,0.16644707246841922,0.18187388802105667,0.7402296489431193,0.4304780594384402,0.3660489787228448,3088]
["P05062","fructose-bisphosphate aldolase B [OS=Homo sapiens]",6,3,32,1,364,39.4,7.87,72.4,"cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;cytoskeleton","cytoskeletal activity;other molecular function","ALDOB","ENSG00000136872","Glycolysis / Gluconeogenesis; Pentose phosphate pathway; Fructose and mannose metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; HIF-1 signaling pathway","Glycolysis; Gluconeogenesis; Fructose catabolism; Hereditary fructose intolerance","Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Glycolysis and gluconeogenesis; Polyol pathway",52.7,46.3,45.4,37,39.8,83.7,0.8996884735202492,-0.15250255512249458,0.7433845182200759,0.12878648779450896,0.8238661779636899,0.08414332579292011,6595]
["P05067-1","Amyloid-beta A4 protein [OS=Homo sapiens]",13,8,19,8,770,86.9,4.82,63.9,"cell adhesion;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function","APP","ENSG00000142192","Serotonergic synapse; Alzheimer disease; Pathways of neurodegeneration","Amyloid fiber formation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Platelet degranulation ; G alpha (q) signalling events; G alpha (i) signalling events; ECM proteoglycans; Lysosome Vesicle Biogenesis; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; TRAF6 mediated NF-kB activation; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Formyl peptide receptors bind formyl peptides and many other ligands; Advanced glycosylation endproduct receptor signaling","Alzheimer's disease and miRNA effects; Endoderm differentiation; Apoptosis-related network due to altered Notch3 in ovarian cancer; Copper homeostasis; TGF-beta signaling pathway; Fragile X syndrome; Inclusion body myositis; Alzheimer's disease",1848.7,1844.9,1904.4,2191.8,2379.7,2105.2,0.838438150583372,-0.254223731059217,0.012466821964041797,1.9042442425427386,0.12815752705370112,0.8922558813885321,711]
["P05089","Arginase-1 [OS=Homo sapiens]",7,2,2,2,322,34.7,7.21,2.25,"other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","ARG1","ENSG00000118520","Arginine biosynthesis; Arginine and proline metabolism; Metabolic pathways; Biosynthesis of amino acids; Amoebiasis","Neutrophil degranulation; Urea cycle","Spinal cord injury; Amino acid metabolism; IL-18 signaling pathway",162.9,199.9,156.4,165.7,189,171.5,0.9866970733561384,-0.019320865166750602,0.8858042587097594,0.052662236074625945,0.9226654306554982,0.03495575071946851,7017]
["P05091","Aldehyde dehydrogenase, mitochondrial [OS=Homo sapiens]",4,2,2,1,517,56.3,7.05,6.5,"other metabolic processes","mitochondrion","other molecular function","ALDH2","ENSG00000111275","Glycolysis / Gluconeogenesis; Ascorbate and aldarate metabolism; Fatty acid degradation; Valine, leucine and isoleucine degradation; Lysine degradation; Arginine and proline metabolism; Histidine metabolism; Tryptophan metabolism; beta-Alanine metabolism; Glycerolipid metabolism; Pyruvate metabolism; Pantothenate and CoA biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Alcoholic liver disease","Ethanol oxidation; Metabolism of serotonin","Fatty acid omega-oxidation; Ethanol effects on histone modifications; Tryptophan metabolism; Fluoroacetic acid toxicity",60.8,68.7,68.8,84,84.5,61.8,0.8610508033000436,-0.21582973356399746,0.2502947718928812,0.6015482217532854,0.4912471771657005,0.3086999321786174,3724]
["P05114","Non-histone chromosomal protein HMG-14 [OS=Homo sapiens]",51,6,23,6,100,10.7,9.6,67.88,"cell organization and biogenesis;DNA metabolism;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HMGN1","ENSG00000205581","","Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER","ATM signaling in development and disease ; p38 MAPK signaling pathway; Malignant pleural mesothelioma; Nucleotide excision repair in xeroderma pigmentosum",2600.3,2465.5,3268.2,2531,2860.3,1567.3,1.1976547006581784,0.2602120204352202,0.37582948061948296,0.42500915619877766,0.5656790926375208,0.24742987238200587,4856]
["P05141","ADP/ATP translocase 2 [OS=Homo sapiens]",52,18,249,5,298,32.8,9.69,692.48,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion","transporter activity;other molecular function","SLC25A5","ENSG00000005022","Calcium signaling pathway; cGMP-PKG signaling pathway; Necroptosis; Cellular senescence; Neutrophil extracellular trap formation; Alzheimer disease; Parkinson disease; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Influenza A; Human T-cell leukemia virus 1 infection; Chemical carcinogenesis; Diabetic cardiomyopathy","Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization","Electron transport chain: OXPHOS system in mitochondria; Alzheimer's disease and miRNA effects; Alzheimer's disease",38025.8,38183.1,38110.6,35261.3,33767.1,49370.8,0.9655428415056858,-0.05058782135973122,0.7979685358486174,0.09801423268024997,0.8627739687156131,0.06410296673791295,6760]
["P05161","Ubiquitin-like protein ISG15 [OS=Homo sapiens]",10,2,3,2,165,17.9,7.44,6.18,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;cytosol;translational apparatus;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ISG15","ENSG00000187608","RIG-I-like receptor signaling pathway; Human papillomavirus infection; Epstein-Barr virus infection; Coronavirus disease","Interferon alpha/beta signaling; ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling","Novel intracellular components of RIG-I-like receptor (RLR) pathway; Non-genomic actions of 1,25 dihydroxyvitamin D3; Cytosolic DNA-sensing pathway; p53 transcriptional gene network; Type II interferon signaling (IFNG)",346.6,353.6,328.6,298.1,264.3,156.3,1.431473493808265,0.5175009566066269,0.07586923075527643,1.1199343192631017,0.30006937640168585,0.5227783242632166,1848]
["P05165-1","Propionyl-CoA carboxylase alpha chain, mitochondrial [OS=Homo sapiens]",28,16,30,16,728,80,7.52,89.32,"other metabolic processes","cytosol;mitochondrion","other molecular function","PCCA","ENSG00000175198","Valine, leucine and isoleucine degradation; Glyoxylate and dicarboxylate metabolism; Propanoate metabolism; Metabolic pathways; Carbon metabolism","Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency; Propionyl-CoA catabolism","",2475.6,2514.1,2516.2,2367.7,2313.9,2650.3,1.0237319112371963,0.033837960487581004,0.6106258328324531,0.21422482660258946,0.7234663984717782,0.14058163496259585,6169]
["P05166-1","propionyl-CoA carboxylase beta chain, mitochondrial [OS=Homo sapiens]",21,9,15,9,539,58.2,7.64,54.36,"other metabolic processes","cytosol;mitochondrion","other molecular function","PCCB","ENSG00000114054","Valine, leucine and isoleucine degradation; Glyoxylate and dicarboxylate metabolism; Propanoate metabolism; Metabolic pathways; Carbon metabolism","Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency; Propionyl-CoA catabolism","",1560.8,1583.1,1640.4,1562.6,1517.8,1395.8,1.0688307046155219,0.09603335824670942,0.13627567251698725,0.8655816660627249,0.3841260664969764,0.41552622094810343,2593]
["P05198","Eukaryotic translation initiation factor 2 subunit 1 [OS=Homo sapiens]",66,20,221,20,315,36.1,5.08,697.51,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;translational apparatus;nucleus;other cell component","translation activity;nucleic acid binding activity","EIF2S1","ENSG00000134001","Autophagy; Protein processing in endoplasmic reticulum; Apoptosis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Prion disease; Pathways of neurodegeneration; Hepatitis C; Measles; Influenza A; Herpes simplex virus 1 infection; Lipid and atherosclerosis","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency","Translation factors; Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; Ebola virus pathway in host; Nonalcoholic fatty liver disease; Unfolded protein response; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; Alzheimer's disease",19238.1,19402.7,19431.3,17837,17392,15061,1.1547444820043749,0.20757365222380234,0.03970055206347759,1.4012034540314702,0.21866717033305028,0.6602164150119326,1327]
["P05204","Non-histone chromosomal protein HMG-17 [OS=Homo sapiens]",16,2,9,2,90,9.4,9.99,21.42,"cell organization and biogenesis;other biological processes","non-structural extracellular;nucleus;other cell component","nucleic acid binding activity;other molecular function","HMGN2","ENSG00000198830","","","",1241.6,1199.4,1274,1221.9,1158.2,975.8,1.1070055722756933,0.14666248415584837,0.19429807840080116,0.7115314945317422,0.44185583541737883,0.35471940507509503,3214]
["P05362","Intercellular adhesion molecule 1 [OS=Homo sapiens]",24,9,19,9,532,57.8,7.99,72.98,"cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","ICAM1","ENSG00000090339","NF-kappa B signaling pathway; Cell adhesion molecules; Natural killer cell mediated cytotoxicity; TNF signaling pathway; Leukocyte transendothelial migration; AGE-RAGE signaling pathway in diabetic complications; African trypanosomiasis; Malaria; Staphylococcus aureus infection; Influenza A; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Rheumatoid arthritis; Viral myocarditis; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","Interleukin-4 and Interleukin-13 signaling; Interferon gamma signaling; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Integrin cell surface interactions; Interleukin-10 signaling","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; RANKL/RANK signaling pathway; Interleukin-11 signaling pathway; Spinal cord injury; Complement system; IL1 and megakaryocytes in obesity; Photodynamic therapy-induced NF-kB survival signaling; VEGFA-VEGFR2 signaling pathway; miRNAs involvement in the immune response in sepsis; Cells and molecules involved in local acute inflammatory response ; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; CAMKK2 pathway; p53 transcriptional gene network; Orexin receptor pathway; Type II interferon signaling (IFNG)",2261.5,2222.7,2238.4,2336.2,2363.9,1999.8,1.0033881102703026,4.87974798293489E-3,0.9517703541267186,0.0214678267905624,0.9684657550204909,0.013915731339888401,7183]
["P05386","60S acidic ribosomal protein P1 [OS=Homo sapiens]",57,3,24,3,114,11.5,4.32,86.06,"protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus","enzyme regulator activity;other molecular function","RPLP1","ENSG00000137818","Ribosome; Coronavirus disease","L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",3083.9,3288.6,2838.8,3507.1,3955.9,3739.2,0.822275981503633,-0.28230540618453515,0.022452662895562834,1.6487321440919922,0.1723807910752823,0.7635111305924936,952]
["P05455","Lupus La protein [OS=Homo sapiens]",70,34,273,34,408,46.8,7.12,717.54,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","nucleus;other cell component","nucleic acid binding activity","SSB","ENSG00000138385","Systemic lupus erythematosus","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination","",39140.9,39105.1,38802.1,38798.5,38169.2,27350.4,1.1220305967995965,0.1661120175235191,0.31733653513626336,0.49847992444969536,0.5367768422381275,0.2702062288769525,4321]
["P06213-1","insulin receptor [OS=Homo sapiens]",10,12,19,11,1382,156.2,6.2,54.6,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","INSR","ENSG00000171105","MAPK signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cGMP-PKG signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Phospholipase D signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Adherens junction; Insulin signaling pathway; Ovarian steroidogenesis; Regulation of lipolysis in adipocytes; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; Aldosterone-regulated sodium reabsorption; Alzheimer disease; Diabetic cardiomyopathy","PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Insulin receptor recycling; IRS activation; Signal attenuation","AMP-activated protein kinase (AMPK) signaling; Selenium micronutrient network; Vitamin B12 metabolism; Type II diabetes mellitus; Folate metabolism; Alzheimer's disease and miRNA effects; AGE/RAGE pathway; Nanoparticle triggered autophagic cell death; Transcription factor regulation in adipogenesis; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; PI3K-Akt signaling pathway; Ras signaling; NRF2-ARE regulation; Nonalcoholic fatty liver disease; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Male infertility; Insulin signaling; 16p11.2 distal deletion syndrome; Neuroinflammation and glutamatergic signaling; Malignant pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)",1631,1614.6,1686.9,1830.5,1811.1,1720.2,0.9199336043865867,-0.12039835554256616,0.024030210686860766,1.6192424214665984,0.17795016201647956,0.7497016122522622,987]
["P06396","Gelsolin [OS=Homo sapiens]",10,8,12,8,782,85.6,6.28,27.52,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","GSN","ENSG00000148180","Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Viral carcinogenesis","Neutrophil degranulation; Amyloid fiber formation; Sensory processing of sound by outer hair cells of the cochlea; Caspase-mediated cleavage of cytoskeletal proteins","Ebola virus pathway in host; Regulation of actin cytoskeleton; Senescence and autophagy in cancer",1558.1,1538,1634.9,1461.6,1570.1,1354.6,1.0785855960604611,0.10914067266137246,0.1705260398073221,0.7682092936149909,0.422499940661599,0.374173347709181,2950]
["P06737-1","Glycogen phosphorylase, liver form [OS=Homo sapiens]",8,7,11,4,847,97.1,7.17,27.47,"other metabolic processes;other biological processes","non-structural extracellular;cytosol;other cell component","other molecular function","PYGL","ENSG00000100504; ENSPPAG00000035478; ENSPTRG00000006337","Starch and sucrose metabolism; Metabolic pathways; Necroptosis; Insulin signaling pathway; Glucagon signaling pathway; Insulin resistance","Neutrophil degranulation; Glycogen breakdown (glycogenolysis)","TNF-alpha signaling pathway; Glycogen synthesis and degradation; Glycogen metabolism",158.8,141.1,163.7,136.8,136.6,233.9,0.9138576779026217,-0.12995859412466765,0.6827827862168172,0.16571743651056384,0.7786642821748662,0.10864974621065764,6409]
["P06858","lipoprotein lipase [OS=Homo sapiens]",1,1,1,1,475,53.1,8.15,1.76,"cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","LPL","ENSG00000175445","Glycerolipid metabolism; PPAR signaling pathway; Cholesterol metabolism; Alzheimer disease","Transcriptional regulation of white adipocyte differentiation; Retinoid metabolism and transport; Assembly of active LPL and LIPC lipase complexes; Chylomicron remodeling","Fatty acid beta-oxidation; Sterol regulatory element-binding proteins (SREBP) signaling; Alzheimer's disease and miRNA effects; Adipogenesis; Aryl hydrocarbon receptor Netpath; Triacylglyceride synthesis; Lipid particles composition; Angiopoietin-like protein 8 regulatory pathway; PPAR signaling pathway; Statin inhibition of cholesterol production; Metabolic pathway of LDL, HDL and TG, including diseases; Overview of leukocyte-intrinsic Hippo pathway functions; Orexin receptor pathway; Familial partial lipodystrophy (FPLD); Familial  hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5; Alzheimer's disease; Vitamin A and carotenoid metabolism",58.9,83.5,58.2,78.7,91.2,91,0.7688769643541589,-0.37917533820527105,0.09648572462099193,1.0155369371944662,0.33170938911327846,0.47924223549777134,2126]
["P07099","epoxide hydrolase 1 [OS=Homo sapiens]",39,15,66,15,455,52.9,7.25,209.82,"other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","EPHX1","ENSG00000143819","Metabolism of xenobiotics by cytochrome P450; Bile secretion; Chemical carcinogenesis; Chemical carcinogenesis; Chemical carcinogenesis","Phase I - Functionalization of compounds","Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Benzene metabolism; Benzo(a)pyrene metabolism; Aflatoxin B1 metabolism; Metapathway biotransformation Phase I and II",7363.6,7833.2,7721.1,6094.4,6182.6,6299.1,1.2337304385742973,0.3030272101969043,7.0560584456818957E-4,3.1514378305786153,0.030698054273505342,1.5128891504205053,168]
["P07311","Acylphosphatase-1 [OS=Homo sapiens]",26,3,5,3,99,11.3,9.31,14.66,"other metabolic processes","","other molecular function","ACYP1","ENSG00000119640","Pyruvate metabolism; Metabolic pathways","","",846.9,824.5,796.7,783.2,854.7,1004.2,0.9341432951061656,-0.09828422238044074,0.43365392709685685,0.3628567163582398,0.5988242118176699,0.2227006484655347,5293]
["P07384","Calpain-1 catalytic subunit [OS=Homo sapiens]",57,35,159,34,714,81.8,5.67,466.75,"protein metabolism;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","CAPN1","ENSG00000014216","Protein processing in endoplasmic reticulum; Apoptosis; Necroptosis; Cellular senescence; Alzheimer disease; Pathways of neurodegeneration; Shigellosis","Degradation of the extracellular matrix; Neutrophil degranulation; Formation of the cornified envelope; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models","Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Alzheimer's disease",16238.8,16779.2,16661.1,15734.6,15584.8,15426,1.0627591164050365,0.0878146345460612,0.006345823966112497,2.1975119794474463,0.08988687474479891,1.0463037191906845,516]
["P07741-1","Adenine phosphoribosyltransferase [OS=Homo sapiens]",74,12,84,12,180,19.6,6.02,249.53,"other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","APRT","ENSG00000198931; ENSPPAG00000005769; ENSPTRG00000008466","Purine metabolism; Metabolic pathways","Neutrophil degranulation; Purine salvage","",9834.6,9913.1,9792,9085.2,8850.8,9965.6,1.0587098947730598,0.08230731953820306,0.1847730812291325,0.7333612989448474,0.4325773384701247,0.3639362357872731,3122]
["P07992-1","DNA excision repair protein ERCC-1 [OS=Homo sapiens]",15,3,3,3,297,32.5,6.25,10.09,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ERCC1","ENSG00000012061; ENSPPAG00000043568; ENSPTRG00000011152","Platinum drug resistance; Nucleotide excision repair; Fanconi anemia pathway","HDR through Single Strand Annealing (SSA); Fanconi Anemia Pathway; Dual incision in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER","Male infertility; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum",254,229.5,251.6,246.1,246.8,166.7,1.114463311097635,0.15634912286168604,0.4150431505568229,0.38190674889147974,0.5856274879188839,0.2323785467527398,5180]
["P08069","Insulin-like growth factor 1 receptor [OS=Homo sapiens]",3,4,5,3,1367,154.7,5.8,12.45,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;transporter activity;kinase activity;other molecular function","IGF1R","ENSG00000140443","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; Ras signaling pathway; Rap1 signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Oocyte meiosis; Autophagy; Endocytosis; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Focal adhesion; Adherens junction; Signaling pathways regulating pluripotency of stem cells; Long-term depression; Ovarian steroidogenesis; Progesterone-mediated oocyte maturation; Pathways in cancer; Transcriptional misregulation in cancer; Proteoglycans in cancer; Glioma; Prostate cancer; Melanoma; Breast cancer; Hepatocellular carcinoma","Extra-nuclear estrogen signaling; IRS-related events triggered by IGF1R; Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R); SHC-related events triggered by IGF1R","MicroRNAs in cardiomyocyte hypertrophy; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Apoptosis; Focal adhesion; MECP2 and associated Rett syndrome; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Ebola virus pathway in host; Ras signaling; Breast cancer pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Head and neck squamous cell carcinoma; Endochondral ossification; EGFR tyrosine kinase inhibitor resistance; Endochondral ossification with skeletal dysplasias; Insulin signaling; Malignant pleural mesothelioma; Senescence and autophagy in cancer",253.1,251.3,271.8,268.1,282.5,241.7,0.9796794143632465,-0.02961836910280066,0.7137865411568123,0.14643164516774307,0.8015157212037396,0.09608795482565323,6509]
["P08237","ATP-dependent 6-phosphofructokinase, muscle type [OS=Homo sapiens]",48,27,99,24,780,85.1,7.99,319.74,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus","kinase activity;other molecular function","PFKM","ENSG00000152556","Glycolysis / Gluconeogenesis; Pentose phosphate pathway; Fructose and mannose metabolism; Galactose metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; RNA degradation; HIF-1 signaling pathway; AMPK signaling pathway; Thyroid hormone signaling pathway; Glucagon signaling pathway; Central carbon metabolism in cancer","Glycolysis","Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Insulin signaling; Glycolysis and gluconeogenesis",10244.6,10268.6,10241.2,10073.3,9877,9264.2,1.0527101268205858,0.07410823202316287,0.10303868113748833,0.9869997087806224,0.34015795864223225,0.46831936343935343,2214]
["P08582-1","Melanotransferrin [OS=Homo sapiens]",10,5,7,5,738,80.2,5.94,23.52,"transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","MELTF","ENSG00000163975","","Post-translational modification: synthesis of GPI-anchored proteins; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","3q29 copy number variation syndrome",463.8,482.6,465.5,398.5,444.5,603.6,0.9760127194801606,-0.03502814565311649,0.8620180416686403,0.06448364448255116,0.9073286098151053,0.042235394767013705,6944]
["P08670","Vimentin [OS=Homo sapiens]",82,44,1256,40,466,53.6,5.12,3152.9,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","VIM","ENSG00000026025","Epstein-Barr virus infection; MicroRNAs in cancer","Aggrephagy; Interleukin-4 and Interleukin-13 signaling; Chaperone Mediated Autophagy; Late endosomal microautophagy; Striated Muscle Contraction; RHOBTB1 GTPase cycle; Caspase-mediated cleavage of cytoskeletal proteins","Allograft Rejection; Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Mammary gland development pathway - Puberty (Stage 2 of 4); Apoptosis-related network due to altered Notch3 in ovarian cancer; Striated muscle contraction pathway; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Ciliary landscape; Burn wound healing; CCL18 signaling pathway; T-cell receptor (TCR) signaling pathway",129448.7,129500.9,128304.4,130907,135923,127700.4,0.9815568077897167,-0.02685632852567297,0.37370922260193573,0.42746618425979177,0.5637648520118779,0.2489020037626029,4845]
["P08887-1","Interleukin-6 receptor subunit alpha [OS=Homo sapiens]",2,1,1,1,468,51.5,8.22,2.3,"other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","other molecular function","IL6R","ENSG00000160712","EGFR tyrosine kinase inhibitor resistance; Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor; HIF-1 signaling pathway; PI3K-Akt signaling pathway; JAK-STAT signaling pathway; Hematopoietic cell lineage; Th17 cell differentiation; Non-alcoholic fatty liver disease; Human cytomegalovirus infection; Coronavirus disease; Pathways in cancer","Transcriptional regulation of granulopoiesis; Potential therapeutics for SARS; Interleukin-4 and Interleukin-13 signaling; Interleukin-6 signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation","Pluripotent stem cell differentiation pathway; IL-6 signaling pathway; Hepatitis C and hepatocellular carcinoma; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Nonalcoholic fatty liver disease; Regulatory circuits of the STAT3 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Neuroinflammation and glutamatergic signaling; Senescence and autophagy in cancer; Sudden infant death syndrome (SIDS) susceptibility pathways",60.9,86,89.1,154.7,185.5,598.3,0.2514651038891849,-1.991569885469033,0.1775487084544513,0.7506824825465113,0.42772033951667254,0.36884009711325,3034]
["P09001","39S ribosomal protein L3, mitochondrial [OS=Homo sapiens]",47,10,38,10,348,38.6,9.48,101.96,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL3","ENSG00000114686","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",3574.8,3468.9,3472.5,3648.6,3500.9,4087.2,0.9358797511724972,-0.09560492141606579,0.2517871706161765,0.5989664023955404,0.4931169426671045,0.3070500755860298,3732]
["P09493-1","Tropomyosin alpha-1 chain [OS=Homo sapiens]",28,10,53,1,284,32.7,4.74,127.27,"cell organization and biogenesis;stress response;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","TPM1","ENSG00000140416; ENSGGOG00000009130; ENSPPAG00000004536; ENSPTRG00000007141","Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; MicroRNAs in cancer; Hypertrophic cardiomyopathy; Dilated cardiomyopathy","Smooth Muscle Contraction; Striated Muscle Contraction","Vitamin D receptor pathway; Striated muscle contraction pathway",71.7,79.5,76.4,76.2,86.4,75.3,0.9567044976881041,-0.06385471411855298,0.4615690842715001,0.3357632877637928,0.6199206977104731,0.20766386332355866,5442]
["P09543-1","2',3'-cyclic-nucleotide 3'-phosphodiesterase [OS=Homo sapiens]",47,20,86,19,421,47.5,9.07,280.98,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;mitochondrion;other cell component","nucleic acid binding activity;other molecular function","CNP","ENSG00000173786; ENSPTRG00000009187","","","Glial cell differentiation; MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation",9391.9,9688.9,9622.7,7974.1,7824.9,8818.6,1.1659747497725206,0.22153654602348005,0.01340262748548971,1.8728100530837128,0.13309756017859278,0.8758299055372387,736]
["P09651-1","Heterogeneous nuclear ribonucleoprotein A1 [OS=Homo sapiens]",68,24,322,1,372,38.7,9.13,982.14,"RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HNRNPA1; HNRPA1","ENSCANG00000041992; ENSCATG00000043560; ENSG00000135486; ENSMFAG00000031561; ENSMLEG00000044414; ENSMMUG00000012989; ENSMNEG00000042992; ENSPANG00000010434; ENSPPAG00000018027; ENSPTRG00000049417; ENSRBIG00000029387; ENSRROG00000030782","Spliceosome; Amyotrophic lateral sclerosis","mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA","mRNA processing; mRNA Processing",23322.4,23368.4,22190.3,27543.6,30740.5,37046.8,0.7225474636240716,-0.4688357345599045,0.035242190189242156,1.4529371094102461,0.20789763365066258,0.6821504539023365,1239]
["P09960-1","leukotriene A-4 hydrolase [OS=Homo sapiens]",49,28,124,28,611,69.2,6.18,365.67,"protein metabolism;other metabolic processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","LTA4H","ENSG00000111144; ENSPTRG00000005321","Arachidonic acid metabolism; Metabolic pathways","Neutrophil degranulation; Biosynthesis of protectins; Synthesis of Leukotrienes (LT) and Eoxins (EX); Biosynthesis of D-series resolvins; Biosynthesis of E-series 18(S)-resolvins; Biosynthesis of aspirin-triggered D-series resolvins; Biosynthesis of E-series 18(R)-resolvins","Eicosanoid synthesis; Eicosanoid metabolism via lipooxygenases (LOX); Prostaglandin and leukotriene metabolism in senescence",17670.7,17233.8,17734.5,15498.6,14364.9,10633.3,1.2998310977657492,0.37832416921773426,0.05200101419288872,1.283988186094433,0.2489033482225433,0.6039692612668812,1527]
["P0CAP2-1","DNA-directed RNA polymerase II subunit GRINL1A [OS=Homo sapiens]",22,5,6,5,368,41.7,6.39,18.32,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction","nucleus;other cell component","other molecular function","POLR2M","ENSG00000255529","RNA polymerase","","",376.7,342,408,453.7,443.1,391.5,0.8745633780951642,-0.1933651573379912,0.11739700114873075,0.9303429967953255,0.3609821966327611,0.4425142166395327,2377]
["P0CG08","Golgi pH regulator B [OS=Homo sapiens]",11,3,12,3,455,52.9,9.28,50.47,"transport;developmental processes;other biological processes","other membranes;ER/Golgi","transporter activity","GPR89B","ENSG00000188092","","","",419.2,452.7,428,365.1,387.5,180.3,1.3933969342909207,0.4786062942347464,0.1392774755326489,0.8561191136036509,0.38854162926264535,0.41056244303942346,2620]
["P0DMV8","heat shock 70 kDa protein 1A [OS=Homo sapiens]",57,32,354,17,641,70,5.66,921,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","HSPA1A","ENSG00000204389; ENSG00000215328; ENSG00000234475; ENSG00000235941; ENSG00000237724","Spliceosome; MAPK signaling pathway; Protein processing in endoplasmic reticulum; Endocytosis; Longevity regulating pathway; Antigen processing and presentation; Estrogen signaling pathway; Prion disease; Legionellosis; Toxoplasmosis; Measles; Lipid and atherosclerosis","AUF1 (hnRNP D0) binds and destabilizes mRNA; Neutrophil degranulation; Regulation of HSF1-mediated heat shock response; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase; Viral RNP Complexes in the Host Cell Nucleus","Apoptosis modulation and signaling; Parkin-ubiquitin proteasomal system pathway; Nuclear receptors meta-pathway; NRF2 pathway; MAPK signaling pathway; Apoptosis modulation by HSP70; VEGFA-VEGFR2 signaling pathway",18850.3,18729.7,18876.1,17641.2,18213.1,12665.8,1.1635610808716386,0.2185469466758941,0.20769874776510852,0.682566121858463,0.45492063152987056,0.34206436662928275,3337]
["P10114","Ras-related protein Rap-2a [OS=Homo sapiens]",50,8,41,4,183,20.6,4.82,124.75,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","RAP2A","ENSG00000125249","","","",564.6,635,640.9,533.1,554.3,508.7,1.1531232378923624,0.2055467065673815,0.04290994421012665,1.3674420501200872,0.22563221743296094,0.6465988884902093,1390]
["P10412","Histone H1.4 [OS=Homo sapiens]",45,17,408,3,219,21.9,11.03,1195.29,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","H1-4","ENSG00000168298","","Formation of Senescence-Associated Heterochromatin Foci (SAHF); Apoptosis induced DNA fragmentation","Pathways affected in adenoid cystic carcinoma; Genotoxicity pathway",19572.3,20125.5,20015.1,19487.2,20849.3,63072.8,0.5774422609958678,-0.7922513976043827,0.36624235989952747,0.43623142626400413,0.5598965506182068,0.2518922080758205,4781]
["P10747-1","T-cell-specific surface glycoprotein CD28 [OS=Homo sapiens]",8,2,6,2,220,25.1,9.39,14.27,"developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","CD28","ENSG00000178562; ENSGGOG00000041735; ENSPPAG00000034998; ENSPTRG00000012833","Cell adhesion molecules; T cell receptor signaling pathway; Intestinal immune network for IgA production; Type I diabetes mellitus; Measles; PD-L1 expression and PD-1 checkpoint pathway in cancer; Autoimmune thyroid disease; Systemic lupus erythematosus; Rheumatoid arthritis; Allograft rejection; Graft-versus-host disease; Viral myocarditis","PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; CD28 dependent PI3K/Akt signaling; CD28 dependent Vav1 pathway; Nef mediated downregulation of CD28 cell surface expression","Allograft Rejection; T cell receptor and co-stimulatory signaling; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Control of immune tolerance by vasoactive intestinal peptide; Selective expression of chemokine receptors during T-cell polarization; Inflammatory response pathway; Cancer immunotherapy by CTLA4 blockade; Modulators of TCR signaling and T cell activation; Prostaglandin signaling; T-cell receptor (TCR) signaling pathway",683.1,797.6,797.8,745,787.5,578.1,1.079550838624088,0.11043118491099108,0.4940361375419074,0.3062412823293395,0.6415973932647123,0.19273740920807464,5628]
["P10909-1","Clusterin [OS=Homo sapiens]",14,5,10,5,449,52.5,6.27,34.37,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","CLU","ENSG00000120885","Complement and coagulation cascades","Platelet degranulation ; Regulation of Complement cascade; Antimicrobial peptides; Terminal pathway of complement","Male infertility; Complement system in neuronal development and plasticity; Complement and coagulation cascades",716.3,711.2,715.9,558.1,559.1,681.8,1.1914396887159535,0.25270592341854764,0.0491529393805858,1.3084505059376774,0.24323550029295976,0.613973039365654,1477]
["P11169","Solute carrier family 2, facilitated glucose transporter member 3 [OS=Homo sapiens]",4,2,2,2,496,53.9,7.2,4.48,"other metabolic processes;transport","plasma membrane;other membranes;other cell component","transporter activity;other molecular function","SLC2A3","ENSG00000059804","","Neutrophil degranulation; Cellular hexose transport; Vitamin C (ascorbate) metabolism; MECP2 regulates neuronal receptors and channels","Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced HIF-1 survival signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K/AKT/mTOR - VitD3 signaling; Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis",139.7,158,146.7,124.1,138,223.9,0.9144032921810699,-0.1290974971040514,0.6840192044096012,0.16493170492895468,0.7793447178534334,0.10827040375592901,6415]
["P11277","Spectrin beta chain, erythrocytic [OS=Homo sapiens]",9,19,54,9,2137,246.3,5.27,150.96,"cell organization and biogenesis","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity","SPTB","ENSG00000070182","","COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins","",930.4,937,910.9,1072.7,1069,1293.3,0.80882096069869,-0.30610770953538763,0.04258052798517227,1.3707889577491474,0.22568606167050334,0.6464952620410243,1379]
["P11279","Lysosome-associated membrane glycoprotein 1 [OS=Homo sapiens]",19,8,56,8,417,44.9,8.75,149.71,"transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","LAMP1","ENSG00000185896","Autophagy; Lysosome; Phagosome; Tuberculosis","Neutrophil degranulation","Senescence and autophagy in cancer",6428.7,6382.2,6493.7,5392.4,5142.9,3420.5,1.3832671720718266,0.46807983370959405,0.0453684413588924,1.3432461407441185,0.23172462466257482,0.6350278126199219,1431]
["P11717","Cation-independent mannose-6-phosphate receptor [OS=Homo sapiens]",37,74,213,74,2491,274.2,5.94,668.87,"protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","IGF2R","ENSG00000197081","Lysosome; Endocytosis","Neutrophil degranulation; Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; Retrograde transport at the Trans-Golgi-Network","",21689.8,22041.5,21755.5,21247.2,20754,25221,0.9741841236972311,-0.037733623154197586,0.7042249293448309,0.15228860510328876,0.7941953415493549,0.10007266467246682,6481]
["P11908","ribose-phosphate pyrophosphokinase 2 [OS=Homo sapiens]",54,16,99,7,318,34.7,6.61,304.64,"other metabolic processes","other cell component","kinase activity;other molecular function","PRPS2","ENSG00000101911","Pentose phosphate pathway; Purine metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids","5-Phosphoribose 1-diphosphate biosynthesis","Nucleotide metabolism",6363.8,6681.9,6613.1,5733.5,5548.9,3222.2,1.3553493374515675,0.4386647500682457,0.10237058094523119,0.9898248321182004,0.34010298914940673,0.4683895510564336,2200]
["P12259","Coagulation factor V [OS=Homo sapiens]",2,4,10,4,2224,251.5,6.05,25.4,"stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","F5","ENSG00000198734","Complement and coagulation cascades","COPII-mediated vesicle transport; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Common Pathway of Fibrin Clot Formation; Cargo concentration in the ER","Blood clotting cascade; Complement and coagulation cascades",1140,1071,1112,849.8,919,901.3,1.244522677053294,0.31559251860682314,1.6538804737488933E-3,2.7814958801927894,0.04544440745349873,1.3425195549398836,266]
["P12956","X-ray repair cross-complementing protein 6 [OS=Homo sapiens]",67,39,511,39,609,69.8,6.64,1565.56,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","XRCC6","ENSG00000196419","Non-homologous end-joining","Neutrophil degranulation; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation; IRF3-mediated induction of type I IFN","Non-homologous end joining; DNA repair pathways, full network",53772.2,52887.6,52360.6,51563.2,50782.5,39669.3,1.1197436890469314,0.16316853508724488,0.21619116574056615,0.6651620566755486,0.4628416023426473,0.3345676115702904,3414]
["P13073","Cytochrome c oxidase subunit 4 isoform 1, mitochondrial [OS=Homo sapiens]",36,7,70,7,169,19.6,9.51,154.87,"other metabolic processes;transport;other biological processes","other membranes;cytosol;mitochondrion;nucleus","transporter activity","COX4I1","ENSG00000131143","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly",7995.1,8472.3,8013.3,8249.7,9117.7,8181.7,0.9581824800090806,-0.061627660289003176,0.353191673098841,0.45198954396721513,0.554679402380625,0.25595796103395335,4654]
["P13598","Intercellular adhesion molecule 2 [OS=Homo sapiens]",8,2,2,2,275,30.6,7.43,7.3,"cell adhesion","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding","ICAM2","ENSG00000108622","Cell adhesion molecules; Natural killer cell mediated cytotoxicity","Integrin cell surface interactions; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; CD209 (DC-SIGN) signaling","Complement system; Ebola virus pathway in host",384.2,388.6,361.9,396.1,407.2,325.5,1.005226789510985,0.007521024977881297,0.9452010095646265,0.024475823171585382,0.96419737319021,0.015834056020975706,7165]
["P13747","HLA class I histocompatibility antigen, alpha chain E [OS=Homo sapiens]",38,11,40,9,358,40.1,5.95,128.11,"other biological processes","plasma membrane;other membranes","","HLA-E","","","","",1622.8,1681.1,1667.1,1898.5,1966.6,1759.2,0.8838433227246058,-0.17813744649427016,0.02656972575023081,1.575612928306174,0.18530355487446276,0.7321162490699089,1048]
["P13796","Plastin-2 [OS=Homo sapiens]",79,45,1261,36,627,70.2,5.43,3790.82,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","LCP1","ENSG00000136167","","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","",144205.1,140449,140788.7,137380.8,136450.6,145636.5,1.0142439981700626,0.020404765363109846,0.5622742398458567,0.25005181289654876,0.6919788548633384,0.15990717628959739,5939]
["P13995","Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [OS=Homo sapiens]",38,9,47,9,350,37.9,8.73,177.98,"other metabolic processes","mitochondrion","other molecular function","MTHFD2","ENSG00000065911","One carbon pool by folate; Metabolic pathways; Biosynthesis of cofactors","Metabolism of folate and pterines","Folate metabolism; One-carbon metabolism; Trans-sulfuration and one-carbon metabolism; Nucleotide metabolism",4542.9,4659.9,4547.1,4830.6,5119,3691.1,1.0080054542655434,0.011503445207434813,0.9377047089813562,0.027933903039132135,0.9586912460406675,0.01832123822127775,7149]
["P14174","Macrophage Migration inhibitory factor [OS=Homo sapiens]",32,3,25,3,115,12.5,7.88,55.83,"cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","MIF","ENSG00000240972; ENSG00000276701","Tyrosine metabolism; Phenylalanine metabolism; Metabolic pathways","Neutrophil degranulation; Cell surface interactions at the vascular wall; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","Adipogenesis; Spinal cord injury",2725.1,2835,2673.4,3106.4,3011.1,2404.9,0.9661010982821742,-0.049753926159051276,0.6904174163654171,0.1608882617076895,0.7843116096075278,0.10551135638966752,6434]
["P14373","Zinc finger protein RFP [OS=Homo sapiens]",13,5,6,5,513,58.5,6.21,17.27,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","TRIM27","ENSG00000204713; ENSG00000215641; ENSG00000229006; ENSG00000234495; ENSG00000237071","","Regulation of PTEN stability and activity; SUMOylation of ubiquitinylation proteins; Suppression of apoptosis","",337.4,369.8,342.6,445,486.3,537,0.7149765034393517,-0.48403226408518435,0.008012672941757098,2.096222583764515,0.10402242723144339,0.9828730167318881,563]
["P14678-1","Small nuclear ribonucleoprotein-associated proteins B and B' [OS=Homo sapiens]",22,7,33,7,240,24.6,11.19,98.36,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","Snrpb; SNRPB; SNRPN","ENSANAG00000024443; ENSCANG00000019461; ENSCCAG00000026002; ENSG00000125835; ENSLCNG00005019999; ENSMLEG00000022346; ENSMMUG00000010050; ENSNLEG00000029067; ENSOGAG00000016149; ENSPANG00000020362; ENSRROG00000036094; ENSSBOG00000027310","Spliceosome; Systemic lupus erythematosus","snRNP Assembly; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs","mRNA processing",4241,4461.8,4193.6,4194.5,3615.8,2313.5,1.2738694956439283,0.3492174851049939,0.17562355586841244,0.7554172338879735,0.4264560032698427,0.37012576759784394,3010]
["P14927","Cytochrome b-c1 complex subunit 7 [OS=Homo sapiens]",22,2,4,2,111,13.5,8.78,11.24,"other metabolic processes","other membranes;mitochondrion","","UQCRB","ENSG00000156467","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly",165.7,153.1,174,158.4,140.6,164.2,1.0639032815198617,0.08936700270566457,0.3505953363132172,0.4551938652727608,0.5540543379704442,0.2564476404638393,4625]
["P15121","aldose reductase [OS=Homo sapiens]",72,18,128,16,316,35.8,6.98,425.69,"other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","AKR1B1","ENSG00000085662","Pentose and glucuronate interconversions; Fructose and mannose metabolism; Galactose metabolism; Glycerolipid metabolism; Folate biosynthesis; Metabolic pathways","Pregnenolone biosynthesis; Fructose biosynthesis","Eicosanoid metabolism via cyclooxygenases (COX); Polyol pathway; Metapathway biotransformation Phase I and II",18285.4,17790.3,17765.6,17357.7,15029.1,12368.3,1.2030204378942286,0.2666611524044178,0.10519543632359767,0.9780031007000559,0.34294087604334317,0.46478074707503725,2242]
["P15374","Ubiquitin carboxyl-terminal hydrolase isozyme L3 [OS=Homo sapiens]",45,9,42,9,230,26.2,4.92,127.2,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","UCHL3","ENSG00000118939","","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; UCH proteinases; Neddylation","Proteasome degradation",4528.4,4491.6,4435.6,4776.4,5126.4,5348.8,0.8822418631487845,-0.18075387569027543,0.023858222510352592,1.6223619153471909,0.17739547134096348,0.7510574712953535,983]
["P15498-1","Proto-oncogene vav [OS=Homo sapiens]",45,38,162,36,845,98.3,6.62,478.58,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","enzyme regulator activity;other molecular function","VAV1","ENSG00000141968; ENSPTRG00000010378","Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Focal adhesion; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Yersinia infection; Proteoglycans in cancer; Lipid and atherosclerosis","RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC1 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated phagocytosis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; NRAGE signals death through JNK; G alpha (12/13) signalling events; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Regulation of signaling by CBL; GPVI-mediated activation cascade; Signaling by SCF-KIT; VEGFR2 mediated vascular permeability; Erythropoietin activates RAS; CD28 dependent Vav1 pathway","Prolactin signaling pathway; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL-6 signaling pathway; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; EGF/EGFR signaling pathway; Modulators of TCR signaling and T cell activation; Regulation of actin cytoskeleton; Interferon type I signaling pathways; T-cell receptor (TCR) signaling pathway; EGFR1 signaling pathway; Kit receptor signaling pathway",22036.5,21602.7,21777,21633.1,20300.9,16884.7,1.1121667088867995,0.15337305789744227,0.19629025872471398,0.7071012525501568,0.44321455082450867,0.35338599006875693,3237]
["P15924-1","Desmoplakin [OS=Homo sapiens]",30,80,151,80,2871,331.6,6.81,424.21,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","DSP","ENSG00000096696","Arrhythmogenic right ventricular cardiomyopathy","Neutrophil degranulation; Formation of the cornified envelope; RND3 GTPase cycle; RND1 GTPase cycle; Apoptotic cleavage of cell adhesion  proteins","Arrhythmogenic right ventricular cardiomyopathy; Lung fibrosis; Epithelial to mesenchymal transition in colorectal cancer",16694.3,16394.6,16219.4,15221.4,15465.3,16655.7,{"$f":"AVERAGE(S1282:U1282)/AVERAGE(V1282:X1282)","v":1.0415251444793674},{"$f":"LOG(Y1282,2)","v":0.05869766931403796},{"$f":"TTEST(S1282:U1282,V1282:X1282,2,2)","v":0.23094751396840763},{"$f":"-LOG10(AA1282)","v":0.6364867083497291},{"$f":"AA1282*7309/AE1282","v":0.47415600550423914},{"$f":"-LOG10(AC1282)","v":0.32407874443863127},3560]
["P16035","Metalloproteinase inhibitor 2 [OS=Homo sapiens]",10,2,3,2,220,24.4,7.49,10.74,"developmental processes;other biological processes","non-structural extracellular;extracellular matrix;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","TIMP2","ENSG00000035862","","Neutrophil degranulation; Activation of Matrix Metalloproteinases","Matrix metalloproteinases; Angiogenesis; IL1 and megakaryocytes in obesity; Vitamin D receptor pathway; Burn wound healing; CCL18 signaling pathway",261.9,191.6,183.9,240.2,230.6,427.5,0.7095625069575866,-0.49499831475149747,0.27443819484663456,0.5615554459653757,0.5092329947027296,0.2930834648905445,3939]
["P16219","Short-chain specific acyl-CoA dehydrogenase, mitochondrial [OS=Homo sapiens]",6,2,5,2,412,44.3,7.99,12.11,"other metabolic processes","cytoskeleton;mitochondrion;nucleus","other molecular function","ACADS","ENSG00000122971","Fatty acid degradation; Valine, leucine and isoleucine degradation; beta-Alanine metabolism; Propanoate metabolism; Butanoate metabolism; Metabolic pathways; Carbon metabolism; Fatty acid metabolism","Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA","Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation; IL-18 signaling pathway",173.7,186,190.3,164.7,150.3,395.4,0.7742117117117118,-0.3691999630507216,0.5384070885585853,0.26888923091332817,0.674647250175673,0.1709232454593706,5833]
["P16402","Histone H1.3 [OS=Homo sapiens]",47,17,377,5,221,22.3,11.02,1091.22,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity","H1-3","ENSG00000124575","","Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)","",12484.8,12966.4,12939.9,11628.8,12293.5,17280.9,0.9317504465672569,-0.10198448948143941,0.6282634502104893,0.20185820502003732,0.7379041551644652,0.13200004412053487,6223]
["P16619","C-C motif chemokine 3-like 1 [OS=Homo sapiens]",24,2,10,2,93,10.2,4.89,30.53,"stress response;signal transduction;other biological processes","non-structural extracellular","signal transduction activity or receptor binding","CCL3L1; CCL3L3","ENSG00000276085; ENSG00000277336; ENSG00000277768; ENSG00000277796","Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor; Chemokine signaling pathway; Toll-like receptor signaling pathway; Chagas disease; Human cytomegalovirus infection; Rheumatoid arthritis; Lipid and atherosclerosis","Chemokine receptors bind chemokines; Interleukin-10 signaling","Overview of proinflammatory and profibrotic mediators",942.1,1029.7,946.9,1691.6,2014.3,2191.2,0.49493818995777594,-1.014679728501825,2.6352476645983827E-3,2.5791785628749695,0.05854414948495313,1.232516498940971,329]
["P16949-1","Stathmin [OS=Homo sapiens]",36,6,9,6,149,17.3,5.97,21.91,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity","LOC101348598; Stathmin; STMN1","ENSAMEG00000010298; ENSANAG00000030242; ENSBIXG00000025259; ENSBTAG00000013761; ENSCAFG00000029191; ENSCATG00000016402; ENSCCAG00000028161; ENSCHIG00000023552; ENSCJAG00000009462; ENSCSAG00000000960; ENSFCAG00000040721; ENSG00000117632; ENSGGOG00000026648; ENSLCNG00005009740; ENSMFAG00000041588; ENSMLEG00000037590; ENSMLUG00000010762; ENSMMUG00000000653; ENSMNEG00000044643; ENSNLEG00000009154; ENSOARG00000005764; ENSOGAG00000002109; ENSPANG00000010315; ENSPCTG00005008718; ENSPPAG00000038785; ENSPPYG00000001700; ENSPTRG00000000369; ENSRBIG00000033291; ENSRFEG00010003199; ENSRROG00000019821; ENSSBOG00000029102; ENSSSCG00000026257; ENSSSCG00005028094; ENSSSCG00015059883; ENSSSCG00055018660; ENSSSCG00070026240; ENSSSUG00005019081; ENSTTRG00000012495; ENSUAMG00000025721; ENSUMAG00000012809; ENSVVUG00000011613","MAPK signaling pathway; MicroRNAs in cancer","Nuclear signaling by ERBB4","MAPK signaling pathway; Microtubule cytoskeleton regulation; Retinoblastoma gene in cancer; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; EGF/EGFR signaling pathway; IL-18 signaling pathway; MAPK signaling pathway; MAPK signaling pathway",1139,1014.5,826,907.4,893.1,1262.4,0.97277090339221,-0.03982801799685418,0.86308345545518,0.06394720835048831,0.90766575193121,0.04207405105662927,6950]
["P17096-1","High mobility group protein HMG-I/HMG-Y [OS=Homo sapiens]",48,4,8,4,107,11.7,10.32,24.83,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","HMGA1; LOC111152215","ENSAMEG00000001061; ENSCAFG00030004107; ENSCAFG00040011381; ENSCANG00000029050; ENSCATG00000042051; ENSCCAG00000024304; ENSCSAG00000009775; ENSECAG00000000734; ENSFCAG00000044104; ENSG00000137309; ENSGGOG00000025804; ENSMLEG00000042857; ENSMMUG00000019529; ENSMNEG00000005671; ENSPCTG00005015441; ENSPTRG00000040884; ENSRBIG00000030072; ENSRFEG00010017624; ENSUAMG00000015725; ENSUMAG00000010910","","Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Formation of Senescence-Associated Heterochromatin Foci (SAHF)","Adipogenesis; Adipogenesis; Pre-implantation embryo; Male infertility; 7q11.23 copy number variation syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Orexin receptor pathway; Senescence and autophagy in cancer; Adipogenesis",986.2,973.6,1148.5,762.8,836.2,978.3,1.2060295658247004,0.27026527535228756,0.10484051223696486,0.979470865814489,0.3430077457206697,0.46469607271010627,2234]
["P17152","Transmembrane protein 11, mitochondrial [OS=Homo sapiens]",14,3,9,3,192,21.5,7.36,21.08,"cell organization and biogenesis","plasma membrane;other membranes;mitochondrion","","TMEM11","ENSG00000178307","","Cristae formation","",1339,1302.7,1297.5,1303.4,1190.6,847.1,1.1790128999431324,0.23757950337464923,0.2216111061009042,0.6544084786120412,0.46584859778300514,0.33175520741132664,3477]
["P17612","cAMP-dependent protein kinase catalytic subunit alpha [OS=Homo sapiens]",37,15,43,9,351,40.6,8.79,135.85,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","kinase activity;other molecular function","PRKACA","ENSG00000072062; ENSG00000288516","Endocrine resistance; MAPK signaling pathway; Ras signaling pathway; Calcium signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Oocyte meiosis; Autophagy; Longevity regulating pathway; Longevity regulating pathway; Adrenergic signaling in cardiomyocytes; Vascular smooth muscle contraction; Wnt signaling pathway; Hedgehog signaling pathway; Apelin signaling pathway; Tight junction; Gap junction; Platelet activation; Circadian entrainment; Thermogenesis; Long-term potentiation; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; GABAergic synapse; Dopaminergic synapse; Olfactory transduction; Taste transduction; Inflammatory mediator regulation of TRP channels; Insulin signaling pathway; Insulin secretion; GnRH signaling pathway; Ovarian steroidogenesis; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Melanogenesis; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Regulation of lipolysis in adipocytes; Renin secretion; Aldosterone synthesis and secretion; Relaxin signaling pathway; Cortisol synthesis and secretion; Parathyroid hormone synthesis, secretion and action; Cushing syndrome; Growth hormone synthesis, secretion and action; Endocrine and other factor-regulated calcium reabsorption; Vasopressin-regulated water reabsorption; Salivary secretion; Gastric acid secretion; Bile secretion; Parkinson disease; Prion disease; Cocaine addiction; Amphetamine addiction; Morphine addiction; Alcoholism; Vibrio cholerae infection; Amoebiasis; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; Chemical carcinogenesis; Dilated cardiomyopathy","Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; MAPK6/MAPK4 signaling; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Interleukin-3, Interleukin-5 and GM-CSF signaling; Factors involved in megakaryocyte development and platelet production; VEGFA-VEGFR2 Pathway; RET signaling; ROBO receptors bind AKAP5; FCGR3A-mediated IL10 synthesis; Triglyceride catabolism; ADORA2B mediated anti-inflammatory cytokines production; Ion homeostasis; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; Regulation of MECP2 expression and activity; PKA activation; PKA activation in glucagon signalling; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; CD209 (DC-SIGN) signaling; Rap1 signalling; HDL assembly; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase; Loss of phosphorylation of MECP2 at T308; PKA-mediated phosphorylation of key metabolic factors","Nicotine effect on dopaminergic neurons; Sterol regulatory element-binding proteins (SREBP) signaling; Follicle stimulating hormone (FSH) signaling pathway; Microtubule cytoskeleton regulation; Dopamine metabolism; Common pathways underlying drug addiction; Complement system; Mesodermal commitment pathway; IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Mesodermal commitment pathway; G protein signaling pathways; MAPK signaling pathway; Cannabinoid receptor signaling; Lipid metabolism pathway; Ras signaling; Hedgehog signaling pathway; Thermogenesis; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Neuroinflammation and glutamatergic signaling; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways; Estrogen signaling pathway",5718.4,5857.3,5870.8,5135,5190.1,3977.9,1.2197790673285325,0.2866198630885459,0.05809686691475333,1.2358472878906186,0.2617940815535956,0.5820401758817829,1622]
["P17931","Galectin-3 [OS=Homo sapiens]",6,1,1,1,250,26.1,8.56,3.66,"RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","LGALS3","ENSG00000131981","","Neutrophil degranulation; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; Advanced glycosylation endproduct receptor signaling; RUNX2 regulates genes involved in differentiation of myeloid cells","AGE/RAGE pathway; Spinal cord injury",80.3,73.9,72.2,87.1,78.4,143.9,0.7317388493859082,-0.4505992386171534,0.25203790881134663,0.5985341324351858,0.4933436195774324,0.3068504841642724,3734]
["P18031","Tyrosine-protein phosphatase non-receptor type 1 [OS=Homo sapiens]",46,18,62,18,435,49.9,6.27,198.79,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","PTPN1","ENSG00000196396","Adherens junction; Insulin signaling pathway; Insulin resistance; Chemical carcinogenesis","MECP2 regulates neuronal receptors and channels; Growth hormone receptor signaling; Regulation of IFNG signaling; Regulation of IFNA signaling; Negative regulation of MET activity; Integrin signaling; PTK6 Down-Regulation","Leptin signaling pathway; Prolactin signaling pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Insulin signaling",7971,8134.1,8264.2,7986.6,8039.4,9097.7,0.9699725756954589,-0.0439841367293195,0.5357999724981204,0.270997313019551,0.672995703555381,0.17198770832898885,5819]
["P18583-5","Isoform D of Protein SON [OS=Homo sapiens]",24,37,125,6,2459,266.9,5.73,394.66,"","","","SON","","","","",12529.7,12395.6,12600.2,15412.3,15806,14191.3,0.8263781226877136,-0.2751260336995468,0.005823862401017933,2.2347888945440184,0.08704828279967294,1.0602397917836657,489]
["P18827","syndecan-1 [OS=Homo sapiens]",16,5,34,5,310,32.4,4.63,131.88,"cell-cell signaling;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SDC1","ENSG00000115884","ECM-receptor interaction; Cell adhesion molecules; Malaria; Proteoglycans in cancer; Fluid shear stress and atherosclerosis","Cell surface interactions at the vascular wall; A tetrasaccharide linker sequence is required for GAG synthesis; HS-GAG biosynthesis; HS-GAG degradation; Defective B4GALT7 causes EDS, progeroid type; Defective B3GAT3 causes JDSSDHD; Defective EXT2 causes exostoses 2; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Defective B3GALT6 causes EDSP2 and SEMDJL1; Retinoid metabolism and transport; Syndecan interactions; Other interleukin signaling","",3730.4,3873.8,3897,4475.8,5044,2149.4,0.9856031261783157,-0.020921262845213333,0.9526898473062664,0.02104846297844011,0.9688618469405178,0.013738145951214968,7187]
["P18850","Cyclic AMP-dependent transcription factor ATF-6 alpha [OS=Homo sapiens]",2,1,1,1,670,74.5,8.22,0,"stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","ATF6","ENSG00000118217","Protein processing in endoplasmic reticulum; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Lipid and atherosclerosis","ATF4 activates genes in response to endoplasmic reticulum  stress; ATF6 (ATF6-alpha) activates chaperone genes","Sterol regulatory element-binding proteins (SREBP) signaling; Alzheimer's disease and miRNA effects; Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling pathway; Unfolded protein response; Alzheimer's disease",27.7,28.9,27.6,36.4,37.6,85,0.5295597484276728,-0.9171346271053219,0.1943611307701605,0.7113905829275513,0.44158703910447716,0.3549836819455482,3217]
["P19388","DNA-directed RNA polymerases I, II, and III subunit RPABC1 [OS=Homo sapiens]",21,4,11,4,210,24.5,5.95,29.4,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR2E","ENSG00000099817","RNA polymerase; Cytosolic DNA-sensing pathway; Huntington disease","mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; RNA Polymerase I Promoter Escape; Inhibition of DNA recombination at telomere; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Viral Messenger RNA Synthesis; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM","Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway",1115.9,1279.4,1150.1,1571.6,1482.2,1502.5,0.7781313785308255,-0.361914336651155,0.00401203664336982,2.3966351090662164,0.07405044400603539,1.130472333107756,396]
["P19397","Leukocyte surface antigen CD53 [OS=Homo sapiens]",13,4,10,4,219,24.3,7.52,23.32,"signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","CD53","ENSG00000143119","","Neutrophil degranulation","",1081.1,1080.3,1143.5,1157.8,981.6,2309.8,0.7428076957655307,-0.4289393326764235,0.4121069241037452,0.3849900885213076,0.5840778569467274,0.23352925804404956,5157]
["P19784","casein kinase II subunit alpha' [OS=Homo sapiens]",51,14,25,13,350,41.2,8.56,89.99,"cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","CSNK2A2","ENSG00000070770","Ribosome biogenesis in eukaryotes; NF-kappa B signaling pathway; Mitophagy; Wnt signaling pathway; Adherens junction; Alzheimer disease; Prion disease; Pathways of neurodegeneration; Measles; PD-L1 expression and PD-1 checkpoint pathway in cancer","ROS sensing by NFE2L2; Regulation of PTEN stability and activity; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of TP53 Activity through Phosphorylation; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Receptor Mediated Mitophagy; Condensation of Prometaphase Chromosomes; Synthesis of PC","Alzheimer's disease and miRNA effects; Allograft Rejection; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Malignant pleural mesothelioma; Alzheimer's disease",2143.6,2209.6,2140.5,1917.2,1925.8,2333.4,1.051372968072016,0.07227454726059022,0.4895618581623873,0.3101924254925416,0.6385095683991593,0.19483259022230565,5604]
["P20036","HLA class II histocompatibility antigen, DP alpha 1 chain [OS=Homo sapiens]",18,3,4,3,260,29.4,5.21,16,"stress response;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","HLA-DPA1","ENSG00000168384; ENSG00000206291; ENSG00000224103; ENSG00000228163; ENSG00000229685; ENSG00000231389; ENSG00000235844; ENSG00000236177","Phagosome; Cell adhesion molecules; Antigen processing and presentation; Hematopoietic cell lineage; Th1 and Th2 cell differentiation; Th17 cell differentiation; Intestinal immune network for IgA production; Type I diabetes mellitus; Leishmaniasis; Toxoplasmosis; Staphylococcus aureus infection; Tuberculosis; Influenza A; Human T-cell leukemia virus 1 infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Asthma; Autoimmune thyroid disease; Inflammatory bowel disease; Systemic lupus erythematosus; Rheumatoid arthritis; Allograft rejection; Graft-versus-host disease; Viral myocarditis","Downstream TCR signaling; Generation of second messenger molecules; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling","Allograft Rejection; Ebola virus pathway in host",328.4,352.1,363.2,298.3,325,639.9,0.8262349588347057,-0.27537599151919023,0.542925067363969,0.2652601060943276,0.6782155729556057,0.16863224232107288,5851]
["P20073-1","Annexin A7 [OS=Homo sapiens]",34,16,117,16,488,52.7,5.68,287.16,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ANXA7","ENSG00000138279","Amyotrophic lateral sclerosis","","",10895.5,10594.9,10611.9,11141.7,9707.5,10186.5,1.0343668742770424,0.04874797851924086,0.4574045803218067,0.3396994908037647,0.6162525488612138,0.21024127144035887,5425]
["P20340-2","Isoform 2 of Ras-related protein Rab-6A [OS=Homo sapiens]",45,11,48,1,208,23.5,5.54,102.09,"","","","RAB6A","","","","",179.9,199.7,186.9,178.9,162.4,257,0.9468494066521813,-0.07879310694707745,0.7395724654799342,0.13101926613472156,0.8218846206770319,0.0851891461100048,6577]
["P20701-1","Integrin alpha-L [OS=Homo sapiens]",11,8,11,8,1170,128.7,5.63,35.18,"cell adhesion;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","ITGAL","ENSG00000005844","Rap1 signaling pathway; Cell adhesion molecules; Neutrophil extracellular trap formation; Natural killer cell mediated cytotoxicity; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Malaria; Staphylococcus aureus infection; Human T-cell leukemia virus 1 infection; Epstein-Barr virus infection; Rheumatoid arthritis; Viral myocarditis","Neutrophil degranulation; Integrin cell surface interactions; Cell surface interactions at the vascular wall; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; RUNX3 Regulates Immune Response and Cell Migration","Integrin-mediated cell adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Acute viral myocarditis; Cells and molecules involved in local acute inflammatory response ; Overview of leukocyte-intrinsic Hippo pathway functions; CCL18 signaling pathway",1115.1,1147.1,1252.4,1152.1,1154.8,626.2,1.1982544066005252,0.2609342455016578,0.343533770371316,0.46403056409199583,0.5513588773921715,0.2585656284871468,4554]
["P20810-6","Isoform 6 of Calpastatin [OS=Homo sapiens]",65,41,192,1,791,84.9,5.36,471.87,"","","","CAST","","","","",19228.2,19289.9,20047.7,21697.8,22478.2,21107.5,0.8970995733990977,-0.15665996918946948,9.309039820145781E-3,2.031095111963591,0.11154060991056643,0.9525669850903852,610]
["P21333-2","Isoform 2 of Filamin-A [OS=Homo sapiens]",58,114,509,103,2639,279.8,6.05,1811.48,"","","","FLNA","","","","",61638.5,60626.6,61028.9,48158.1,49246.1,54612.5,1.2057491051969946,0.2699297394563604,0.006651863381060679,2.177056679094847,0.09260660848032856,1.0333580206168307,525]
["P21359-1","Neurofibromin [OS=Homo sapiens]",3,6,6,6,2839,319.2,7.39,17.78,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","NF1","ENSG00000196712","EGFR tyrosine kinase inhibitor resistance; MAPK signaling pathway; Ras signaling pathway","Regulation of RAS by GAPs; RAS signaling downstream of NF1 loss-of-function variants","Pilocytic astrocytoma; Glioblastoma signaling pathways; Aryl hydrocarbon receptor Netpath; MECP2 and associated Rett syndrome; MAPK signaling pathway; Ras signaling; Transcription co-factors SKI and SKIL protein partners; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Melanoma; EGFR tyrosine kinase inhibitor resistance",285.7,302.8,281.1,286.4,312.5,522.7,0.7753209700427961,-0.36713440898331384,0.3259152957061664,0.4868952569484702,0.53955037289159,0.26796800297808465,4415]
["P21964-1","Catechol O-methyltransferase [OS=Homo sapiens]",44,9,29,9,271,30,5.47,77.17,"other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","COMT","ENSG00000093010","Steroid hormone biosynthesis; Tyrosine metabolism; Metabolic pathways; Dopaminergic synapse","Potential therapeutics for SARS; Methylation; Enzymatic degradation of dopamine by COMT; Enzymatic degradation of Dopamine by monoamine oxidase","Dopamine metabolism; MTHFR deficiency; 22q11.2 copy number variation syndrome; Biogenic amine synthesis; Estrogen metabolism; Metapathway biotransformation Phase I and II; Methylation pathways",3106.5,3295.4,3230.3,3229.1,3047.8,2946,1.044378666146223,0.06264489267587495,0.24267426256739727,0.6149762814252652,0.4838260188502746,0.31531078016749003,3666]
["P22304","iduronate 2-sulfatase [OS=Homo sapiens]",9,3,6,3,550,61.8,5.45,24.23,"other metabolic processes","other cytoplasmic organelle","other molecular function","IDS","ENSG00000010404","Glycosaminoglycan degradation; Metabolic pathways; Lysosome","HS-GAG degradation; CS/DS degradation; MPS II - Hunter syndrome","Glycosaminoglycan degradation",223.5,227.4,211.1,212.4,249.1,432.3,0.7406578652942493,-0.4331208277004301,0.3204865208277984,0.4941902315217932,0.537625884950741,0.26951982957357407,4357]
["P22392-2","Isoform 3 of Nucleoside diphosphate kinase B [OS=Homo sapiens]",81,15,248,2,267,30.1,8.92,730.63,"","","","NME2","","","","",39515.8,39151,37683,42051.2,38268.9,30943.6,1.0457121235407416,0.06448574345691564,0.6353168491392399,0.19700962665566707,0.7429649360573928,0.1290316821157693,6250]
["P22695","Cytochrome b-c1 complex subunit 2, mitochondrial [OS=Homo sapiens]",48,17,119,17,453,48.4,8.63,367.02,"protein metabolism;other metabolic processes;other biological processes","other membranes;mitochondrion;nucleus","other molecular function","UQCRC2","ENSG00000140740","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly",13707.9,13686.5,13814.7,12580.4,11553.9,12864,1.1138106345426682,0.15550397250849377,0.024677803330380943,1.6076935012008948,0.17876121361918168,0.7477267055538322,1009]
["P23229-1","integrin alpha-6 [OS=Homo sapiens]",2,2,2,2,1130,126.5,6.61,6.6,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","ITGA6","ENSG00000091409","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Cell adhesion molecules; Hematopoietic cell lineage; Regulation of actin cytoskeleton; Toxoplasmosis; Human papillomavirus infection; Pathways in cancer; Small cell lung cancer; Hypertrophic cardiomyopathy; Arrhythmogenic right ventricular cardiomyopathy; Dilated cardiomyopathy","Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; Syndecan interactions; Laminin interactions; Basigin interactions; Type I hemidesmosome assembly","Integrin-mediated cell adhesion; Arrhythmogenic right ventricular cardiomyopathy; Alpha 6 beta 4 signaling pathway; Mammary gland development pathway - Embryonic development (Stage 1 of 4); Focal adhesion; Regulation of apoptosis by parathyroid hormone-related protein; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ebola virus pathway in host; Small cell lung cancer; Malignant pleural mesothelioma",126.5,114,114.7,127.8,131.9,155.5,0.8554913294797687,-0.225174862007775,0.10398332715761097,0.9830362905466661,0.34173297580709466,0.466313111572713,2224]
["P23284","peptidyl-prolyl cis-trans isomerase B [OS=Homo sapiens]",64,18,453,16,216,23.7,9.41,1131.48,"protein metabolism;other metabolic processes;developmental processes;other biological processes","ER/Golgi;nucleus;other cell component","other molecular function","PPIB","ENSG00000166794","","Collagen biosynthesis and modifying enzymes","Prolactin signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta",73249.7,70983.3,69678.5,68583.8,66200.7,65807.1,1.0664030796902761,0.0927528519381296,0.030720739201076628,1.5125683385400617,0.19923503355871258,0.7006342927021953,1127]
["P23434","Glycine cleavage system H protein, mitochondrial [OS=Homo sapiens]",39,3,11,3,173,18.9,4.88,37.11,"protein metabolism;other metabolic processes","mitochondrion;other cell component","other molecular function","GCSH","ENSG00000140905","Glycine, serine and threonine metabolism; Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism","Glycine degradation","",943.3,931.7,926.8,931.4,933.5,597,1.1380640968357774,0.18658181386857545,0.3686601301550922,0.43337382792116536,0.5611280490011596,0.2509380217582009,4802]
["P23468-1","Receptor-type tyrosine-protein phosphatase delta [OS=Homo sapiens]",2,2,2,2,1912,214.6,6.57,8.19,"cell adhesion;cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","PTPRD","ENSG00000153707; ENSG00000282932","","Synaptic adhesion-like molecules; Receptor-type tyrosine-protein phosphatases","",45.8,42.7,46.8,32.4,41.1,51,1.0867469879518072,0.12001609702109386,0.5493863304259825,0.26012215069343514,0.6827860379329206,0.16571536821149982,5881]
["P23634-1","Plasma membrane calcium-transporting ATPase 4 [OS=Homo sapiens]",21,20,33,10,1241,137.8,6.6,122.21,"stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","transporter activity;enzyme regulator activity;other molecular function","ATP2B4","ENSG00000058668","Calcium signaling pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Adrenergic signaling in cardiomyocytes; Aldosterone synthesis and secretion; Endocrine and other factor-regulated calcium reabsorption; Salivary secretion; Pancreatic secretion; Mineral absorption","Ion homeostasis; Ion transport by P-type ATPases; Reduction of cytosolic Ca++ levels","Vitamin D-sensitive calcium signaling in depression",888.1,977.8,933.9,769.9,845.3,698.4,1.210148686030429,0.275184316442276,0.03103979598326814,1.5080811419123044,0.1998853469970985,0.6992190415574728,1135]
["P24539","ATP synthase F(0) complex subunit B1, mitochondrial [OS=Homo sapiens]",43,12,65,12,256,28.9,9.36,184.57,"other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","ATP5PB","ENSG00000116459","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation",7467.8,7449.4,7595.7,6015.5,6791.4,6791.5,1.1487111192750428,0.20001603106524,0.020872037836534248,1.680435146624243,0.16709060739017395,0.7770479622745691,913]
["P24752","Acetyl-CoA acetyltransferase, mitochondrial [OS=Homo sapiens]",64,25,217,25,427,45.2,8.85,726.81,"other metabolic processes;stress response;developmental processes;other biological processes","mitochondrion","other molecular function","ACAT1","ENSG00000075239","Fatty acid degradation; Valine, leucine and isoleucine degradation; Lysine degradation; Tryptophan metabolism; Pyruvate metabolism; Glyoxylate and dicarboxylate metabolism; Butanoate metabolism; Terpenoid backbone biosynthesis; Metabolic pathways; Carbon metabolism; Fatty acid metabolism; Fat digestion and absorption","Branched-chain amino acid catabolism; Utilization of Ketone Bodies; Synthesis of Ketone Bodies","Fatty acid beta-oxidation; Ketone bodies synthesis and degradation; Tryptophan metabolism; SARS-CoV-2 and COVID-19 pathway",26522.1,26537.5,27003.4,25531.4,24854.7,34794.1,0.9399250060460058,-0.08938244205627026,0.6233132647594781,0.20529363076796187,0.7333864539805257,0.1346671159405098,6212]
["P25440-1","Bromodomain-containing protein 2 [OS=Homo sapiens]",3,2,2,2,801,88,9.09,5.99,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","kinase activity;other molecular function","BRD2","ENSG00000204256; ENSG00000215077; ENSG00000234507; ENSG00000234704; ENSG00000235307; ENSGGOG00000043461","","RUNX3 regulates p14-ARF","",150.2,173.6,153.5,679.3,697.2,375.8,0.2723848656052046,-1.8762815491104032,0.015277425093867458,1.8159498369748368,0.14152433461480007,0.8491688783002842,789]
["P25786-1","Proteasome subunit alpha type-1 [OS=Homo sapiens]",64,17,151,17,263,29.5,6.61,439.06,"protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","PSMA1","ENSCANG00000029071; ENSCATG00000014932; ENSCJAG00000009850; ENSCPOG00000015226; ENSG00000129084; ENSGGOG00000001416; ENSHGLG00000008245; ENSMFAG00000036829; ENSMLEG00000030594; ENSMMUG00000016446; ENSMNEG00000005235; ENSOCUG00000000439; ENSPANG00000016448; ENSPPYG00000003466; ENSPTRG00000003385; ENSRBIG00000037598; ENSRROG00000037748; ENSSSCG00000013391; ENSSTOG00000006270; ENSTSYG00000003869","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration","ER-Phagosome pathway; MAPK6/MAPK4 signaling; Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Downstream TCR signaling; UCH proteinases; Regulation of expression of SLITs and ROBOs; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease",16226.3,16021,15628.5,16137.9,16086.5,14506.1,1.0245086185681729,0.03493212091652195,0.5352923838530493,0.27140893572010766,0.6728206420605224,0.1721006929006019,5815]
["P26006","Integrin alpha-3 [OS=Homo sapiens]",1,1,1,1,1051,116.5,6.77,1.82,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","ITGA3","ENSG00000005884","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Hematopoietic cell lineage; Regulation of actin cytoskeleton; Human papillomavirus infection; Pathways in cancer; Small cell lung cancer; Hypertrophic cardiomyopathy; Arrhythmogenic right ventricular cardiomyopathy; Dilated cardiomyopathy","Integrin cell surface interactions; Laminin interactions; MET activates PTK2 signaling; Basigin interactions","Integrin-mediated cell adhesion; Arrhythmogenic right ventricular cardiomyopathy; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ebola virus pathway in host; Small cell lung cancer; Nephrotic syndrome; Genes controlling nephrogenesis; Malignant pleural mesothelioma",69.8,64.1,81.9,65.1,65.7,93.6,0.961675579322638,-0.05637781112077611,0.8032132053430575,0.09516916005901897,0.8669056878104558,0.06202814761194367,6772]
["P26358-1","DNA (cytosine-5)-methyltransferase 1 [OS=Homo sapiens]",36,45,110,1,1616,183.1,7.75,300.92,"cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DNMT1","ENSG00000130816","Cysteine and methionine metabolism; Metabolic pathways; MicroRNAs in cancer","NoRC negatively regulates rRNA expression; PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; SUMOylation of DNA methylation proteins","Trans-sulfuration pathway; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration and one-carbon metabolism; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; MTHFR deficiency",395.4,413.6,409.3,622.5,699,270,0.7655042412818095,-0.38551772387780187,0.40005894142485043,0.3978760185475881,0.5777575188449382,0.2382543939724027,5061]
["P26373-1","60S ribosomal protein L13 [OS=Homo sapiens]",39,10,37,10,211,24.2,11.65,99.04,"protein metabolism;other metabolic processes;developmental processes","cytosol;ER/Golgi;translational apparatus;nucleus","other molecular function","RPL13","ENSG00000167526","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",5359.3,6641.4,6495.5,5994.4,6414.3,5247.7,1.047563489726105,0.06703768405565523,0.625144724835583,0.20401942918156266,0.7351862902370517,0.13360260027525325,6215]
["P26885","Peptidyl-prolyl cis-trans isomerase FKBP2 [OS=Homo sapiens]",44,4,14,4,142,15.6,9.13,41.59,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","FKBP2","ENSG00000173486","","","Complement system",1398.5,1515.6,1614.6,1422,1491.2,2248,0.8774509803921569,-0.1886095647072392,0.48127943183305116,0.3176026981237648,0.6327885172275177,0.19874141027835185,5559]
["P27540","Aryl hydrocarbon receptor nuclear translocator [OS=Homo sapiens]",4,3,4,3,789,86.6,6.54,8.99,"stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","ARNT","ENSG00000143437","HIF-1 signaling pathway; Cushing syndrome; Pathways in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Renal cell carcinoma","PPARA activates gene expression; Endogenous sterols; Xenobiotics; Aryl hydrocarbon receptor signalling; Regulation of gene expression by Hypoxia-inducible Factor","Angiogenesis; Aryl hydrocarbon receptor Netpath; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; Type 2 papillary renal cell carcinoma",390.4,339.1,360.9,386.6,382.1,407.9,0.9267380588135307,-0.10976647410809542,0.1635449585530649,0.7863628389210282,0.4156293818026256,0.3812937587479003,2876]
["P27695","DNA-(apurinic or apyrimidinic site) lyase [OS=Homo sapiens]",61,17,74,17,318,35.5,8.12,255.72,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytoskeleton;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component","nucleic acid binding activity;other molecular function","APEX1","ENSG00000100823","Base excision repair","Displacement of DNA glycosylase by APEX1; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Abasic sugar-phosphate removal via the single-nucleotide replacement pathway","Thyroid stimulating hormone (TSH) signaling pathway; Spinal cord injury; Base excision repair; DNA repair pathways, full network",9154.4,9388.8,9098,8739.9,9806.9,6166.9,1.118456564577542,0.161509230214334,0.4189047140179813,0.3778847524091848,0.5878983400071861,0.2306977660853474,5208]
["P27986","Phosphatidylinositol 3-kinase regulatory subunit alpha [OS=Homo sapiens]",16,10,16,9,724,83.5,6.16,43.18,"cell adhesion;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","PIK3R1","ENSG00000145675","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; Platinum drug resistance; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Phosphatidylinositol signaling system; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Osteoclast differentiation; Focal adhesion; Signaling pathways regulating pluripotency of stem cells; Platelet activation; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; TNF signaling pathway; Leukocyte transendothelial migration; Neurotrophin signaling pathway; Cholinergic synapse; Inflammatory mediator regulation of TRP channels; Regulation of actin cytoskeleton; Insulin signaling pathway; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Prolactin signaling pathway; Thyroid hormone signaling pathway; Regulation of lipolysis in adipocytes; Relaxin signaling pathway; GnRH secretion; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Aldosterone-regulated sodium reabsorption; Carbohydrate digestion and absorption; Alzheimer disease; Spinocerebellar ataxia; Prion disease; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection; Chagas disease; Amoebiasis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Signaling by FGFR1 in disease; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; G alpha (q) signalling events; RAC1 GTPase cycle; VEGFA-VEGFR2 Pathway; RHOC GTPase cycle; CDC42 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; RAF/MAP kinase cascade; PI3K Cascade; PI-3K cascade:FGFR4; Signaling by FGFR4 in disease; Downstream TCR signaling; RND2 GTPase cycle; RHOF GTPase cycle; Extra-nuclear estrogen signaling; RHOV GTPase cycle; Signaling by ALK fusions and activated point mutants; RHOU GTPase cycle; Synthesis of PIPs at the plasma membrane; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Regulation of signaling by CBL; Nephrin family interactions; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; Costimulation by the CD28 family; CD28 dependent PI3K/Akt signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; RND3 GTPase cycle; RND1 GTPase cycle; Interleukin-4 and Interleukin-13 signaling; PI3K events in ERBB4 signaling; PI3K events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; GAB1 signalosome; Signaling by cytosolic FGFR1 fusion mutants; PI-3K cascade:FGFR1; PI-3K cascade:FGFR2; Signaling by FGFR2 in disease; PI-3K cascade:FGFR3; Signaling by FGFR3 point mutants in cancer; FLT3 Signaling; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FGFR3 fusions in cancer; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants; GP1b-IX-V activation signalling; MET activates PI3K/AKT signaling; Activated NTRK3 signals through PI3K; Activated NTRK2 signals through PI3K","IL-5 signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase (AMPK) signaling; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Apoptosis; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; IL-6 signaling pathway; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Ebola virus pathway in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Overview of interferons-mediated signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; IL-18 signaling pathway; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; Modulators of TCR signaling and T cell activation; Orexin receptor pathway; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; Interferon type I signaling pathways; Notch signaling pathway (Netpath); ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway",1577.3,1712.9,1615.6,1477,1613.2,1440.8,1.0827190465680865,0.11465892835002464,0.1322126021570431,0.8787271470711245,0.378068039579745,0.42243003467351403,2556]
["P28072","Proteasome subunit beta type-6 [OS=Homo sapiens]",31,7,35,7,239,25.3,4.92,93.1,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","PSMB6","ENSG00000142507","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease",3505.1,3441.3,3334.7,3397.3,3005.1,2059.3,1.2150158951510923,0.2809751876628704,0.20426009178076396,0.6898164772855003,0.4513110673596142,0.34552401628203644,3308]
["P28288","ATP-binding cassette sub-family D member 3 [OS=Homo sapiens]",22,11,28,11,659,75.4,9.36,86.64,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ABCD3","ENSG00000117528","ABC transporters; Peroxisome","RHOA GTPase cycle; RHOC GTPase cycle; Class I peroxisomal membrane protein import; ABC transporters in lipid homeostasis","Nuclear receptors in lipid metabolism and toxicity; Fragile X syndrome",1929.9,1874.6,1950.1,1780.8,1746.5,2376,0.9748106991005031,-0.036806009342593544,0.8213432723374869,0.08547529583537983,0.8804925165025949,0.05527433084427925,6818]
["P28347","Transcriptional enhancer factor TEF-1 [OS=Homo sapiens]",10,2,2,2,426,47.9,8.15,5.03,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TEAD1","ENSG00000187079","Hippo signaling pathway; Hippo signaling pathway","YAP1- and WWTR1 (TAZ)-stimulated gene expression; EGR2 and SOX10-mediated initiation of Schwann cell myelination; RUNX3 regulates YAP1-mediated transcription","Mesodermal commitment pathway; Mesodermal commitment pathway; miR-509-3p alteration of YAP1/ECM axis; Transcription co-factors SKI and SKIL protein partners; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Overview of leukocyte-intrinsic Hippo pathway functions; Malignant pleural mesothelioma",97.2,98.2,93.7,75.2,89.3,51.8,1.3365695792880259,0.4185349435150708,0.09245048265131639,1.0340908172007925,0.32738400082290287,0.4849425482719934,2064]
["P28702","Retinoic acid receptor RXR-beta [OS=Homo sapiens]",12,4,6,4,533,56.9,8.18,23.05,"signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RXRB","ENSG00000204231; ENSG00000206289; ENSG00000227322; ENSG00000228333; ENSG00000231321; ENSG00000235712","PPAR signaling pathway; Th17 cell differentiation; Thyroid hormone signaling pathway; Adipocytokine signaling pathway; Parathyroid hormone synthesis, secretion and action; Pathways in cancer; Transcriptional misregulation in cancer; Chemical carcinogenesis; Thyroid cancer; Small cell lung cancer; Non-small cell lung cancer; Gastric cancer; Lipid and atherosclerosis","NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; PPARA activates gene expression; Nuclear Receptor transcription pathway; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis; Signaling by Retinoic Acid; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose; NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake ; NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis","Vitamin D metabolism; Nuclear receptors; PPAR signaling pathway; Non-small cell lung cancer; Non-genomic actions of 1,25 dihydroxyvitamin D3; Small cell lung cancer; IL-18 signaling pathway; Vitamin A and carotenoid metabolism",486.4,494.3,493.2,627.3,661.4,618.3,0.7728893550078658,-0.371666198727944,4.1563200242492846E-4,3.381291020447224,0.023549258183905443,1.6280227688625,129]
["P29218-1","Inositol monophosphatase 1 [OS=Homo sapiens]",35,8,29,8,277,30.2,5.26,96.42,"other metabolic processes;signal transduction","cytosol;other cell component","other molecular function","IMPA1","ENSG00000133731","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of IP2, IP, and Ins in the cytosol","Integrated breast cancer pathway",2188.3,2211.3,2188.7,2174.2,2075.2,1677.9,1.1115178917888415,0.15253117120546597,0.22038126319321133,0.6568253319513919,0.46473359858026014,0.3327959284453172,3466]
["P29466-1","caspase-1 [OS=Homo sapiens]",45,15,58,15,404,45.1,5.91,200.9,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;other cell component","enzyme regulator activity;other molecular function","CASP1","ENSG00000137752","Necroptosis; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; Amyotrophic lateral sclerosis; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Legionellosis; Yersinia infection; Influenza A; Coronavirus disease; Lipid and atherosclerosis","The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; NOD1/2 Signaling Pathway; TP53 Regulates Transcription of Caspase Activators and Caspases; The AIM2 inflammasome; Pyroptosis; Interleukin-37 signaling; Interleukin-1 processing; The IPAF inflammasome","Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis modulation and signaling; Parkin-ubiquitin proteasomal system pathway; Amyotrophic lateral sclerosis (ALS); Apoptosis; Cytosolic DNA-sensing pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Malignant pleural mesothelioma; Prostaglandin signaling",5263.5,5392.7,5282.7,5615.7,5708.6,4189.2,1.0274212782415315,0.0390278578082661,0.7880683995063505,0.10343608677566452,0.8547250232960256,0.06817358126339385,6739]
["P29597","Non-receptor tyrosine-protein kinase TYK2 [OS=Homo sapiens]",4,6,7,5,1187,133.6,7.15,21.06,"protein metabolism;other metabolic processes;stress response;signal transduction","other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","TYK2","ENSG00000105397","Necroptosis; Osteoclast differentiation; NOD-like receptor signaling pathway; JAK-STAT signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease","Potential therapeutics for SARS; Interleukin-4 and Interleukin-13 signaling; Interleukin-10 signaling; Interleukin-6 signaling; Regulation of IFNA signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; IL-6-type cytokine receptor ligand interactions; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-12 signaling; Interleukin-23 signaling; Interleukin-27 signaling; Other interleukin signaling","Type III interferon signaling; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; IL-6 signaling pathway; IL-4 signaling pathway; Immune response to tuberculosis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Overview of interferons-mediated signaling pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Interferon type I signaling pathways",636.9,586.3,611.6,705.7,732.4,1347.3,0.6587204710275005,-0.6022617094954366,0.20594399465951083,0.6862508675787072,0.45366023416707796,0.3432692873830761,3318]
["P30041","Peroxiredoxin-6 [OS=Homo sapiens]",73,18,185,18,224,25,6.38,666,"other metabolic processes;stress response;other biological processes","non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PRDX6","ENSG00000117592","Glutathione metabolism; Metabolic pathways","Neutrophil degranulation; Detoxification of Reactive Oxygen Species","Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling pathway",24740.8,25175.2,24271.7,23336.3,23487.2,18963.7,1.1276920130359707,0.17337310325409377,0.1365222020847305,0.8647967152254075,0.38452438344404444,0.4150761155259111,2595]
["P30085-1","UMP-CMP kinase [OS=Homo sapiens]",47,10,43,10,196,22.2,5.57,139.27,"other metabolic processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","CMPK1","ENSG00000162368","Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors","Interconversion of nucleotide di- and triphosphates","Pyrimidine metabolism",6378.5,6620.8,6475.8,6616.8,6732.5,5424.5,1.0373552504021561,0.052910040945305874,0.6107017438241222,0.2141708398991525,0.723439067359888,0.14059804204842125,6170]
["P30154","Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [OS=Homo sapiens]",26,13,56,6,601,66.2,4.94,165.5,"protein metabolism;other metabolic processes;other biological processes","other membranes;other cell component","enzyme regulator activity","PPP2R1B","ENSG00000137713","mRNA surveillance pathway; Sphingolipid signaling pathway; Oocyte meiosis; PI3K-Akt signaling pathway; AMPK signaling pathway; Adrenergic signaling in cardiomyocytes; TGF-beta signaling pathway; Hippo signaling pathway; Tight junction; Dopaminergic synapse; Long-term depression; Chagas disease; Hepatitis C; Human papillomavirus infection","Regulation of TP53 Degradation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; DARPP-32 events; Cyclin A/B1/B2 associated events during G2/M transition; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Cyclin D associated events in G1; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; S33 mutants of beta-catenin aren't phosphorylated; S37 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; T41 mutants of beta-catenin aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; MASTL Facilitates Mitotic Progression; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Netrin-UNC5B signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome",1164.1,1164.1,1207.1,1388.8,1393.9,1137.8,0.9017472261191174,-0.14920501476788905,0.20858602782148247,0.6807147862415122,0.4554990371518421,0.34151253671531634,3347]
["P30414","NK-tumor recognition protein [OS=Homo sapiens]",8,12,20,12,1462,165.6,9.99,53.52,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","NKTR","ENSG00000114857","","","",2333.9,2172.2,2187.1,2093.4,2149.7,2438.8,1.0016911357548004,2.4377324791325147E-3,0.9762220967862831,0.010451366313034543,0.9844380940136511,0.006811589097818241,7248]
["P30479","HLA class I histocompatibility antigen, B-41 alpha chain [OS=Homo sapiens]",40,12,106,2,362,40.5,6.54,299.71,"other biological processes","plasma membrane;other membranes","","HLA-B","","","","",3242.9,3308.3,3325.5,2762.2,2901.7,4118.5,1.0096397612037948,0.01384063215456493,0.9454216464959297,0.024374458256807802,0.9641533157860682,0.01585390084237514,7167]
["P30622-2","Isoform 3 of CAP-Gly domain-containing linker protein 1 [OS=Homo sapiens]",28,35,54,1,1392,156.7,5.36,147.85,"","","","CLIP1","","","","",322.1,311.8,331.8,371.3,389,479.7,0.7787903225806453,-0.3606931379627654,0.05500531973072739,1.2595953065425374,0.25542178012191014,0.5927420726816102,1574]
["P31146","Coronin-1A [OS=Homo sapiens]",62,30,362,27,461,51,6.68,1038.25,"cell adhesion;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","CORO1A","ENSG00000102879","Phagosome; Tuberculosis","Prevention of phagosomal-lysosomal fusion","16p11.2 proximal deletion syndrome",41592.7,41309.3,41782,40321.8,39726.6,42214.9,1.019799072984289,0.028284931643949098,0.3497054768623536,0.4562975659965248,0.5540856991950883,0.25642305872081855,4613]
["P31153","S-adenosylmethionine synthase isoform type-2 [OS=Homo sapiens]",59,18,128,14,395,43.6,6.48,410.75,"cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;other cell component","other molecular function","MAT2A","ENSG00000168906","Cysteine and methionine metabolism; Metabolic pathways; Biosynthesis of amino acids; Biosynthesis of cofactors","Methylation","Trans-sulfuration and one-carbon metabolism; Methionine de novo and salvage pathway; One-carbon metabolism and related pathways; Methylation pathways",13656.7,13362.3,13656.6,14292,13405.7,13677.3,0.9830960725075529,-0.024595684875396824,0.45177028509125305,0.3450823379249511,0.6118193466244152,0.2133767941061919,5397]
["P31641","Sodium- and chloride-dependent taurine transporter [OS=Homo sapiens]",1,1,1,1,620,69.8,7.39,0,"transport;other biological processes","plasma membrane;other membranes;other cell component","transporter activity","SLC6A6","ENSG00000131389","","Na+/Cl- dependent neurotransmitter transporters; Amino acid transport across the plasma membrane","Nuclear receptors meta-pathway; NRF2 pathway",61.7,59.5,63.5,74.7,69.1,114.8,0.7142304717710749,-0.4855384088278164,0.1631641897714131,0.7873751512879968,0.4155285933934698,0.3813990861380162,2870]
["P31943","Heterogeneous nuclear ribonucleoprotein H [OS=Homo sapiens]",56,20,433,8,449,49.2,6.3,1435.7,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","HNRNPH1","ENSG00000169045; ENSG00000284254","","mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA","MECP2 and associated Rett syndrome; mRNA processing; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells",31056.5,30731.8,30948.8,32126.9,33206.3,36018.8,0.9150001973320705,-0.1281560403541043,0.06915930966204806,1.1601493504394613,0.2849410340022036,0.5452450040511959,1774]
["P31947-1","14-3-3 protein sigma [OS=Homo sapiens]",62,15,140,11,248,27.8,4.74,392.51,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;nucleus","enzyme regulator activity;other molecular function","SFN","ENSG00000175793; ENSGGOG00000011493; ENSNLEG00000018582; ENSPPAG00000013397; ENSPTRG00000030723","Cell cycle; p53 signaling pathway; Aldosterone-regulated sodium reabsorption","TP53 Regulates Metabolic Genes; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; Activation of BAD and translocation to mitochondria ; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest","miRNA regulation of DNA damage response; Cell cycle; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells; DNA damage response; Calcium regulation in cardiac cells",2148.5,2084.3,2058,2237,2133,2660.6,0.8947742724660769,-0.16040431984841536,0.2061477309437343,0.6858214410907995,0.45369881525677624,0.34323235480521175,3321]
["P32246","C-C chemokine receptor type 1 [OS=Homo sapiens]",3,1,1,1,355,41.1,8.16,1.86,"cell adhesion;cell-cell signaling;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","CCR1","ENSG00000163823","Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor; Chemokine signaling pathway; Human cytomegalovirus infection; Kaposi sarcoma-associated herpesvirus infection","G alpha (i) signalling events; Chemokine receptors bind chemokines; Interleukin-10 signaling","Peptide GPCRs; Chemokine signaling pathway; Selective expression of chemokine receptors during T-cell polarization; GPCRs, class A rhodopsin-like; CCL18 signaling pathway",119.3,117.7,125.1,258.2,272.4,240.4,0.4696498054474709,-1.0903426833262186,1.3861723787091107E-4,3.858182759286163,0.016081799866642682,1.7936653468557717,63]
["P32455","Guanylate-binding protein 1 [OS=Homo sapiens]",35,18,53,16,592,67.9,6.32,161.45,"stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","GBP1","ENSG00000117228","NOD-like receptor signaling pathway","Interferon gamma signaling","Type II interferon signaling (IFNG)",5925.1,5744,5829,5838.2,5614.4,7399.3,0.9281876097369496,-0.1075116556106362,0.46833999923928993,0.32943874910011894,0.6253374231713501,0.20388558029025078,5474]
["P33121","Long-chain-fatty-acid--CoA ligase 1 [OS=Homo sapiens]",8,7,12,6,698,77.9,7.15,31.55,"other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle","other molecular function","ACSL1","ENSG00000151726","Fatty acid biosynthesis; Fatty acid degradation; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; Peroxisome; Ferroptosis; Thermogenesis; Adipocytokine signaling pathway","PPARA activates gene expression; Synthesis of very long-chain fatty acyl-CoAs; alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism","Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters",1031.5,1007.1,1033,954.5,881.7,1926.4,0.816350396002764,-0.2927395725056885,0.5316796010141202,0.2743500019708543,0.6703547013648791,0.17369534045765303,5797]
["P33981","Dual specificity protein kinase TTK [OS=Homo sapiens]",6,5,6,5,857,97,8.16,15.62,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","TTK","ENSG00000112742","Cell cycle","","Cell cycle; Retinoblastoma gene in cancer",597.4,592.8,578.7,596.3,551.9,437.3,1.1156732891832233,0.1579146140111781,0.26922311231112084,0.569887659461735,0.5057187684096587,0.2960909283815047,3891]
["P33993-1","DNA replication licensing factor MCM7 [OS=Homo sapiens]",68,42,230,42,719,81.3,6.46,689.22,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","MCM7","ENSG00000166508","DNA replication; Cell cycle","Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Assembly of the pre-replicative complex; Unwinding of DNA","miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication",24310.9,24943.8,24792.9,24061.8,23234.6,20324.3,1.0950433816863772,0.1309880253552691,0.13578597340176463,0.86714509006167,0.38348519304230977,0.41625140017435974,2588]
["P34932","Heat shock 70 kDa protein 4 [OS=Homo sapiens]",77,56,447,51,840,94.3,5.19,1386.98,"cell organization and biogenesis;stress response;transport","non-structural extracellular;cytosol;mitochondrion;nucleus","other molecular function","HSPA4","ENSG00000170606","Tight junction; Antigen processing and presentation; Lipid and atherosclerosis","Regulation of HSF1-mediated heat shock response","Parkin-ubiquitin proteasomal system pathway",54172.8,53764.1,54793.8,50395.3,50025.7,42113.3,1.1416950165679423,0.191177311954201,0.06842106880440371,1.1648101459909255,0.28349750107221466,0.5474507649027535,1764]
["P35236","Tyrosine-protein phosphatase non-receptor type 7 [OS=Homo sapiens]",31,8,27,8,360,40.5,6.79,80.38,"protein metabolism;other metabolic processes;signal transduction","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","PTPN7","ENSG00000143851","MAPK signaling pathway","Interleukin-37 signaling; Negative regulation of MAPK pathway","MAPK signaling pathway; IL-18 signaling pathway",2896.6,2809.4,2797.6,3030.4,2828.2,2957.7,0.9645316062293706,-0.05209958092270348,0.19405195552956134,0.7120819763642217,0.44198371547695975,0.35459373157575275,3209]
["P35241-1","radixin [OS=Homo sapiens]",55,38,230,19,583,68.5,6.37,622.21,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","RDX","ENSG00000137710; ENSPPAG00000040677; ENSRBIG00000033138; ENSRROG00000036137","Tight junction; Regulation of actin cytoskeleton; Proteoglycans in cancer; MicroRNAs in cancer","Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea","Regulation of actin cytoskeleton",9078.3,9024.5,8915.1,9634.7,9424,10184.9,0.923891039406913,-0.11420537980076015,0.03290355650223063,1.4827571571924147,0.2026049658591438,0.693349914263033,1187]
["P35556","Fibrillin-2 [OS=Homo sapiens]",0,1,1,1,2912,314.6,4.86,0,"developmental processes;other biological processes","non-structural extracellular;extracellular matrix","extracellular structural activity;other molecular function","FBN2","ENSG00000138829","","Degradation of the extracellular matrix; Molecules associated with elastic fibres","Hypothesized pathways in pathogenesis of cardiovascular disease",62.1,24.8,23.8,142.3,61.3,142.3,0.3200346921075455,-1.6436997915913762,0.058115319209713606,1.2357093724066355,0.2617158768353646,0.5821699303488944,1623]
["P35568","Insulin receptor substrate 1 [OS=Homo sapiens]",3,3,5,3,1242,131.5,8.54,11.72,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","IRS1","ENSG00000169047","cGMP-PKG signaling pathway; FoxO signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Neurotrophin signaling pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Regulation of lipolysis in adipocytes; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; Growth hormone synthesis, secretion and action; Aldosterone-regulated sodium reabsorption; Alzheimer disease; MicroRNAs in cancer; Diabetic cardiomyopathy","RAF/MAP kinase cascade; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by ALK fusions and activated point mutants; PI3K Cascade; Interleukin-7 signaling; PI3K/AKT activation; Signaling by ALK; Growth hormone receptor signaling; Signaling by Leptin; SOS-mediated signalling; IRS activation; Signal attenuation; Activated NTRK3 signals through PI3K","Type II diabetes mellitus; Integrated breast cancer pathway; Leptin signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; AGE/RAGE pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Transcription factor regulation in adipogenesis; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; PI3K-Akt signaling pathway; Nonalcoholic fatty liver disease; Gastrin signaling pathway; Insulin signaling; FOXA2 pathway; Neuroinflammation and glutamatergic signaling; Congenital generalized lipodystrophy (CGL); Alzheimer's disease; EPO receptor signaling; Interferon type I signaling pathways; DNA damage response (only ATM dependent)",342.8,327.3,366.6,538.4,529.7,623.2,0.6129604446283924,-0.7061341175124357,0.00240062843711922,2.6196750536856594,0.05641862780355105,1.248577480828524,311]
["P35612-1","Beta-adducin [OS=Homo sapiens]",17,9,14,9,726,80.8,5.92,31.34,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ADD2","ENSG00000075340","","Miscellaneous transport and binding events","",944,897.3,952.6,951.9,917.1,1201.3,0.9099762238217763,-0.13609924432606696,0.3692141825447041,0.4327216248655108,0.5612700624416062,0.25082812197622095,4808]
["P35813","Protein phosphatase 1A [OS=Homo sapiens]",39,13,32,12,382,42.4,5.36,89.7,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus","other molecular function","PPM1A","ENSG00000100614","MAPK signaling pathway","Energy dependent regulation of mTOR by LKB1-AMPK; Downregulation of SMAD2/3:SMAD4 transcriptional activity","TGF-beta signaling pathway; MAPK signaling pathway",3249,3267.3,3215.2,3348.5,3301.5,4933.9,0.8400883985531644,-0.2513869509909261,0.3140337750157744,0.5030236400982985,0.5342813923627316,0.2722299509058247,4296]
["P35998","26S proteasome regulatory subunit 7 [OS=Homo sapiens]",67,25,125,25,433,48.6,5.95,394.41,"protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","PSMC2","ENSG00000161057","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection","Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of expression of SLITs and ROBOs; Downstream TCR signaling; Interleukin-1 signaling; Neutrophil degranulation; AUF1 (hnRNP D0) binds and destabilizes mRNA; MAPK6/MAPK4 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Orc1 removal from chromatin; SCF(Skp2)-mediated degradation of p27/p21; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease",11872.4,12217.8,12032.1,12173,11663.1,9645.7,1.07886374089804,0.10951266580454659,0.32117671948168774,0.49325594212020546,0.5381661262475139,0.26908364147891395,4362]
["P36551","Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial [OS=Homo sapiens]",43,18,69,18,454,50.1,8.25,212.4,"other metabolic processes","cytosol;mitochondrion;other cell component","other molecular function","CPOX","ENSG00000080819","Porphyrin and chlorophyll metabolism; Metabolic pathways; Biosynthesis of cofactors","Heme biosynthesis","Heme biosynthesis",7434.1,7323.6,7456.5,7153.6,6752.8,8091.3,1.009841938020793,0.014129497849512763,0.8651782031361697,0.0628944304915307,0.9084308988252067,0.041708102368346205,6961]
["P36969","Phospholipid hydroperoxide glutathione peroxidase, mitochondrial [OS=Homo sapiens]",38,8,39,8,197,22.2,8.37,102.9,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","GPX4","ENSG00000167468","Glutathione metabolism; Metabolic pathways; Ferroptosis","Synthesis of 15-eicosatetraenoic acid derivatives; Synthesis of 12-eicosatetraenoic acid derivatives; Synthesis of 5-eicosatetraenoic acids","Glutathione metabolism; Selenium micronutrient network; Folate metabolism; One-carbon metabolism and related pathways; Ferroptosis; Metapathway biotransformation Phase I and II",3822.8,3704.9,3645.3,3059.1,2700.2,3102.3,1.2608332581023745,0.3343774956386346,5.007898112010585E-3,2.300344515628639,0.08097948517850745,1.091624988556048,452]
["P37235","Hippocalcin-like protein 1 [OS=Homo sapiens]",52,10,18,10,193,22.3,5.35,42.62,"","other membranes","other molecular function","HPCAL1","ENSG00000115756","","","",2443.4,2293.1,2038.5,2692.4,2662.7,3285.2,0.7841162922583708,-0.35086045863038307,0.05700106089825717,1.2441170612052055,0.2595767938351163,0.5857341360621234,1605]
["P38432","coilin [OS=Homo sapiens]",16,10,16,10,576,62.6,9.07,42.12,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","COIL","ENSG00000121058","","","Genotoxicity pathway",1481,1511.7,1536.2,1873.8,2051.8,2588.2,0.6952777180754705,-0.5243387394104532,0.037180857730522335,1.4296805956470664,0.21148240400964027,0.6747257614304067,1285]
["P38606","V-type proton ATPase catalytic subunit A [OS=Homo sapiens]",66,30,212,30,617,68.3,5.52,604.83,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ATP6V1A","ENSG00000114573","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis","Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Proximal tubule transport",20869.3,20483.1,20604.9,19573.5,18777,16701.5,1.1254323185352029,0.17047929832949887,0.05607827199604303,1.2512053772479872,0.25697560502763545,0.590108102757214,1595]
["P39210","Protein Mpv17 [OS=Homo sapiens]",16,2,3,2,176,19.7,9.47,5.65,"cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","transporter activity","MPV17","ENSG00000115204","Peroxisome","Peroxisomal protein import","",324.4,365.8,297.7,280,369.3,340.7,0.9978787878787879,-0.003063512537830536,0.9840677583680429,0.006974997023725692,0.9894829063023834,0.004591703996921408,7269]
["P40306","Proteasome subunit beta type-10 [OS=Homo sapiens]",27,6,23,6,273,28.9,7.81,77.74,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PSMB10","ENSG00000205220","Proteasome","Regulation of PTEN stability and activity; FCERI mediated NF-kB activation; Downstream TCR signaling; Regulation of expression of SLITs and ROBOs; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; MAPK6/MAPK4 signaling; Degradation of beta-catenin by the destruction complex; ER-Phagosome pathway; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; CDT1 association with the CDC6:ORC:origin complex; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation",2660.8,2750.4,2729.7,2768.7,2808.6,3426.3,0.9041827713359104,-0.14531366666316892,0.25125742281836594,0.5998810991577719,0.4924753294125601,0.3076155206351061,3729]
["P40616","ADP-ribosylation factor-like protein 1 [OS=Homo sapiens]",64,9,33,9,181,20.4,5.72,97.08,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","ARL1","ENSG00000120805","","Retrograde transport at the Trans-Golgi-Network","",2011.3,2261.9,2297.1,2187.3,2186.1,1673.5,1.086556748085796,0.11976352476676634,0.4177611805353907,0.37907191826318015,0.586631406058246,0.23163469022576214,5205]
["P40937-1","Replication factor C subunit 5 [OS=Homo sapiens]",45,13,39,13,340,38.5,7.2,117.6,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RFC5","ENSG00000111445","DNA replication; Nucleotide excision repair; Mismatch repair","Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER","Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair",4461.5,4366.3,4384.8,4415,3909.8,4728.2,1.0122270742358077,0.017532968022165273,0.8355535365655502,0.07802571825399904,0.8894641419687747,0.05087155545975738,6866]
["P41226","ubiquitin-like modifier-activating enzyme 7 [OS=Homo sapiens]",8,7,9,7,1012,111.6,6.04,25.58,"protein metabolism;other metabolic processes;stress response","cytosol;nucleus;other cell component","other molecular function","UBA7","ENSG00000182179","Ubiquitin mediated proteolysis; Parkinson disease; Pathways of neurodegeneration","Termination of translesion DNA synthesis; Antigen processing: Ubiquitination & Proteasome degradation; ISG15 antiviral mechanism; Negative regulators of DDX58/IFIH1 signaling","Proteasome degradation; Parkinson's disease pathway",995.7,984.3,997.4,1052.4,967.9,1962.7,0.7475269897062515,-0.41980242566033527,0.35194739199352215,0.4535222486650764,0.5545125001251678,0.256088659299863,4639]
["P41227-1","N-alpha-acetyltransferase 10 [OS=Homo sapiens]",47,12,58,12,235,26.4,5.64,151.74,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","translation activity;other molecular function","NAA10","ENSCATG00000038709; ENSCSAG00000006823; ENSG00000102030; ENSGGOG00000009788; ENSMFAG00000044161; ENSMMUG00000000322; ENSMNEG00000034261; ENSPPYG00000020861; ENSPTRG00000022419; ENSRROG00000041881","","","",5121.4,5011.7,5227.1,5753.6,5395,7997,{"$f":"AVERAGE(S1794:U1794)/AVERAGE(V1794:X1794)","v":0.8022835534013038},{"$f":"LOG(Y1794,2)","v":-0.3178158721896941},{"$f":"TTEST(S1794:U1794,V1794:X1794,2,2)","v":0.19716737119551975},{"$f":"-LOG10(AA1794)","v":0.705164953908985},{"$f":"AA1794*7309/AE1794","v":0.44450842568416216},{"$f":"-LOG10(AC1794)","v":0.3521200025375083},3242]
["P41567","eukaryotic translation initiation factor 1 [OS=Homo sapiens]",39,4,6,4,113,12.7,7.44,21.11,"protein metabolism;other metabolic processes;other biological processes","translational apparatus;nucleus;other cell component","translation activity;nucleic acid binding activity","EIF1","ENSG00000173812","","","Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell",267.6,284,262.6,293.4,302.3,274.4,0.9357545109757499,-0.09579799697007878,0.149531195126896,0.8252681955790186,0.40255009398986474,0.3951800676199115,2715]
["P42167-2","Isoform Gamma of Lamina-associated polypeptide 2, isoforms beta/gamma [OS=Homo sapiens]",54,18,162,2,345,38.7,9.16,512.19,"","","","TMPO","","","","",515.8,523.8,509.3,585.6,606.7,486.7,0.9225134008338295,-0.11635822634187683,0.3087650298043651,0.5103718929963084,0.5326324292754554,0.27357239511332504,4237]
["P42285","Superkiller viralicidic activity 2-like 2 [OS=Homo sapiens]",29,28,77,28,1042,117.7,6.52,226.12,"RNA metabolism OR transcription;other metabolic processes;stress response","nucleus","other molecular function","MTREX","ENSG00000039123","RNA degradation","Major pathway of rRNA processing in the nucleolus and cytosol; mRNA Splicing - Major Pathway","",7091.9,7336.9,7143.4,9534.3,9726.6,7600.9,0.8030809551109753,-0.31638266797887504,0.061196578590228645,1.2132728579348386,0.2688015582427771,0.5705682180055708,1664]
["P42574","Caspase-3 [OS=Homo sapiens]",50,10,57,9,277,31.6,6.54,162.65,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","CASP3","ENSG00000164305","Platinum drug resistance; MAPK signaling pathway; p53 signaling pathway; Apoptosis; Apoptosis; Natural killer cell mediated cytotoxicity; IL-17 signaling pathway; TNF signaling pathway; Serotonergic synapse; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Alcoholic liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Salmonella infection; Pertussis; Legionellosis; Toxoplasmosis; Amoebiasis; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Colorectal cancer; Small cell lung cancer; Viral myocarditis; Lipid and atherosclerosis","Caspase-mediated cleavage of cytoskeletal proteins; Degradation of the extracellular matrix; Other interleukin signaling; Apoptosis induced DNA fragmentation; Signaling by Hippo; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Caspase activation via Dependence Receptors in the absence of ligand; Pyroptosis; NADE modulates death signalling; Apoptotic cleavage of cell adhesion  proteins; Stimulation of the cell death response by PAK-2p34","miRNA regulation of DNA damage response; Integrated breast cancer pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; AGE/RAGE pathway; Allograft Rejection; Corticotropin-releasing hormone signaling pathway; Parkinson's disease pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Copper homeostasis; Hepatitis C and hepatocellular carcinoma; MAPK signaling pathway; Apoptosis modulation by HSP70; ERK pathway in Huntington's disease; Oxidative damage response; miRNA regulation of p53 pathway in prostate cancer; Prion disease pathway; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; MTHFR deficiency; Acute viral myocarditis; Nonalcoholic fatty liver disease; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; Peroxiredoxin 2 induced ovarian failure; Complement system in neuronal development and plasticity; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; Sudden infant death syndrome (SIDS) susceptibility pathways; DNA damage response",6582.8,6535.9,6596.4,7027.1,6930.9,6633.7,0.9574294497297454,-0.06276191205339253,0.07129981855042629,1.1469115753746264,0.2908093603711305,0.5363916188167598,1792]
["P42680","Tyrosine-protein kinase Tec [OS=Homo sapiens]",8,5,9,5,631,73.5,8.44,26.54,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton","kinase activity;other molecular function","TEC","ENSG00000135605","Osteoclast differentiation; T cell receptor signaling pathway","FCERI mediated Ca+2 mobilization; Interleukin-3, Interleukin-5 and GM-CSF signaling; Signaling by SCF-KIT","Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; Kit receptor signaling pathway",991.5,970.9,963.8,893.9,946.5,1255.9,0.9450634628427477,-0.08151688253321687,0.6428480448095651,0.1918916726430765,0.7492547216573293,0.12537051153445333,6271]
["P42766","60S ribosomal protein L35 [OS=Homo sapiens]",28,4,12,4,123,14.5,11.05,22.64,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;translational apparatus;nucleus","nucleic acid binding activity;other molecular function","RPL35","ENSG00000136942","Ribosome; Coronavirus disease","Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",2382.8,3062,2821.6,2417.4,2643.8,2010.2,1.1689905817801283,0.2252633065386552,0.21670482352396966,0.6641314218295623,0.4625863186731,0.3348072159507049,3424]
["P43243","Matrin-3 [OS=Homo sapiens]",46,44,247,44,847,94.6,6.25,724.57,"stress response;developmental processes;other biological processes","other membranes;nucleus","nucleic acid binding activity;other molecular function","MATR3","ENSG00000015479","Amyotrophic lateral sclerosis","","",32467.7,31404.7,31953.6,34868.3,35524.9,29746.6,0.9569222227326195,-0.06352642559707362,0.4808827132277016,0.3179608346640971,0.6326083065121079,0.19886510984570205,5556]
["P43246-1","DNA mismatch repair protein MSH2 [OS=Homo sapiens]",46,34,131,34,934,104.7,5.77,390.5,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MSH2","ENSG00000095002","Platinum drug resistance; Mismatch repair; Pathways in cancer; Colorectal cancer","TP53 Regulates Transcription of DNA Repair Genes; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MSH3; Defective Mismatch Repair Associated With MSH2; Defective Mismatch Repair Associated With MSH6","RAC1/PAK1/p38/MMP2 pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ciliary landscape; DNA repair pathways, full network; p53 transcriptional gene network; DNA mismatch repair",15197.6,15100,15100,15945.3,15454.3,16052.4,0.9567057236786647,-0.06385286534563199,0.02153533415360705,1.666848385106779,0.1694313857144391,0.7710061372164477,929]
["P43490","nicotinamide phosphoribosyltransferase [OS=Homo sapiens]",64,26,133,26,491,55.5,7.15,417.93,"cell-cell signaling;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","NAMPT","ENSG00000105835","Nicotinate and nicotinamide metabolism; Metabolic pathways; NOD-like receptor signaling pathway","BMAL1:CLOCK,NPAS2 activates circadian gene expression; Nicotinamide salvaging","Adipogenesis; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; Caloric restriction and aging; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence",15559.3,15192.3,15361.3,15764.1,14495.6,14702.5,1.0255926089025893,0.03645777009385899,0.39931244986029074,0.39868714905601316,0.577478174916673,0.23846442475593613,5054]
["P45880","Voltage-dependent anion-selective channel protein 2 [OS=Homo sapiens]",65,14,219,13,294,31.5,7.56,684.41,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","transporter activity;other molecular function","VDAC2","ENSG00000165637","Calcium signaling pathway; cGMP-PKG signaling pathway; Ferroptosis; Necroptosis; Cellular senescence; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Cholesterol metabolism; Alzheimer disease; Parkinson disease; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Human T-cell leukemia virus 1 infection; Chemical carcinogenesis; Diabetic cardiomyopathy","Ub-specific processing proteases; Mitochondrial calcium ion transport","Alzheimer's disease and miRNA effects; Ferroptosis; Alzheimer's disease",19141.4,19432.8,19642.8,16009.5,15971.1,11325.8,1.3443047678865019,0.4268602491835541,0.033450298266128616,1.4756000054071812,0.2032321114107515,0.6920076708630528,1203]
["P46013","Proliferation marker protein Ki-67 [OS=Homo sapiens]",54,140,476,13,3256,358.5,9.45,1457.52,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MKI67","ENSG00000148773","","","Primary focal segmental glomerulosclerosis (FSGS)",60642.7,59659.9,60091.5,58365.7,60126.3,61058.2,1.004700078306791,0.006764894322748741,0.7542891768057903,0.12246212387260795,0.8320403853416121,0.07985559353457616,6626]
["P46108-1","Adapter molecule crk [OS=Homo sapiens]",21,4,6,4,304,33.8,5.55,20.67,"cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","Crk; CRK","ENSANAG00000030093; ENSBTAG00000005665; ENSCANG00000032179; ENSCATG00000041862; ENSCCAG00000032085; ENSG00000167193; ENSGGOG00000006758; ENSLAFG00000010559; ENSMFAG00000000502; ENSMMUG00000040390; ENSMNEG00000039514; ENSPPAG00000029995; ENSPTRG00000045379; ENSRBIG00000006454; ENSRROG00000035466","MAPK signaling pathway; ErbB signaling pathway; Rap1 signaling pathway; Chemokine signaling pathway; Focal adhesion; Fc gamma R-mediated phagocytosis; Neurotrophin signaling pathway; Regulation of actin cytoskeleton; Insulin signaling pathway; Growth hormone synthesis, secretion and action; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection; Human cytomegalovirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; MicroRNAs in cancer; Renal cell carcinoma; Chronic myeloid leukemia","Regulation of signaling by CBL; ARMS-mediated activation; FCGR3A-mediated phagocytosis; Regulation of signaling by CBL; Regulation of actin dynamics for phagocytic cup formation; Downstream signal transduction; VEGFA-VEGFR2 Pathway; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; ARMS-mediated activation; p130Cas linkage to MAPK signaling for integrins; MET activates RAP1 and RAC1; MET receptor recycling","Kit receptor signaling pathway; TCR signaling pathway; B cell receptor signaling pathway; ErbB signaling pathway; Hepatocyte growth factor receptor signaling; Actin cytoskeleton regulation; Integrin-mediated cell adhesion; Integrin-mediated cell adhesion; B cell receptor signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; Focal adhesion; Interferon type I signaling pathways; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Rett syndrome causing genes; EGF/EGFR signaling pathway; Gastrin signaling pathway; Insulin signaling; Regulation of actin cytoskeleton; Interferon type I signaling pathways; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; EGFR1 signaling pathway; MAPK signaling pathway; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; Integrin-mediated cell adhesion; Insulin signaling; EGF/EGFR signaling pathway; MAPK signaling pathway",472.5,538.4,532.9,492.2,510.6,363.9,1.1295822053120657,0.1757892666411287,0.3093179601846291,0.5095948624648947,0.5329573246085464,0.27330756476146484,4242]
["P46736","Lys-63-specific deubiquitinase BRCC36 [OS=Homo sapiens]",27,8,28,1,316,36,5.92,93.21,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","BRCC3","ENSG00000185515","Homologous recombination; NOD-like receptor signaling pathway","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs","",1935.5,1997.3,2008.6,1942.2,1926.3,1714.7,1.0641567559822322,0.0897106831894282,0.19483422758309074,0.7103347458932638,0.44183784343928334,0.35473708952162536,3223]
["P46777","60S ribosomal protein L5 [OS=Homo sapiens]",64,20,365,20,297,34.3,9.72,1037.11,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;ER/Golgi;translational apparatus;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","RPL5","ENSG00000122406","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; SRP-dependent cotranslational protein targeting to membrane; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","VEGFA-VEGFR2 signaling pathway; Cytoplasmic ribosomal proteins",46760.5,46634.6,46841.7,46480.4,47979.2,46094.6,0.9977417964030957,-3.2615831776027877E-3,0.8636525840396342,0.06366092323566022,0.907741837323222,0.04203764769892692,6954]
["P46940","Ras GTPase-activating-like protein IQGAP1 [OS=Homo sapiens]",63,84,618,82,1657,189.1,6.48,2180.23,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","IQGAP1","ENSG00000140575","Adherens junction; Regulation of actin cytoskeleton; Proteoglycans in cancer","Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; RHOV GTPase cycle; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHO GTPases activate IQGAPs; RAC2 GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants","VEGFA-VEGFR2 signaling pathway; Ebola virus pathway in host; Ciliary landscape; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway",63718.6,63141.9,62971.5,56989,56244.8,43318.6,1.2125780249935485,0.2780775824746641,0.06702573954355029,1.1737583854329439,0.280097844667701,0.5526902330276475,1749]
["P46976-2","Isoform GN-1 of Glycogenin-1 [OS=Homo sapiens]",39,10,56,10,333,37.5,5.4,196.35,"","","","GYG1","","","","",5306.1,5451.9,5392.5,4948.4,5270.3,4639,1.0870121216608224,0.12036802846315107,0.0826492745750801,1.0827609539427738,0.3118655383940426,0.5060326127779118,1937]
["P47985","cytochrome b-c1 complex subunit Rieske, mitochondrial [OS=Homo sapiens]",37,10,82,10,274,29.6,8.32,229.58,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity;other molecular function","UQCRFS1","ENSG00000169021","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly",7800.3,7603.2,7680.2,7146.1,6960.7,5919.7,1.1526577285097246,0.20496418108319286,0.057557974093491907,1.2398945006197495,0.260812915467658,0.583670906124738,1613]
["P48163","NADP-dependent malic enzyme [OS=Homo sapiens]",31,13,54,13,572,64.1,6.13,156.68,"other metabolic processes;other biological processes","cytosol;mitochondrion","other molecular function","ME1","ENSG00000065833","Pyruvate metabolism; Metabolic pathways; Carbon metabolism; PPAR signaling pathway","PPARA activates gene expression; Pyruvate metabolism","Nuclear receptors meta-pathway; NRF2 pathway; PPAR signaling pathway; Clear cell renal cell carcinoma pathways; TCA cycle in senescence",5427.3,5127.4,5162.8,5523.8,5140.7,4519.9,1.0351084007270621,0.04978186048037051,0.5942208745414714,0.22605209581923494,0.7123438366448441,0.14731032895718202,6097]
["P48431","Transcription factor SOX-2 [OS=Homo sapiens]",3,1,1,1,317,34.3,9.74,1.83,"cell organization and biogenesis;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SOX2","ENSG00000181449","Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells","Interleukin-4 and Interleukin-13 signaling; POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation; Transcriptional Regulation by MECP2; Deactivation of the beta-catenin transactivating complex; POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation","Cell differentiation - expanded index; Cardiac progenitor differentiation; Endoderm differentiation; Dopaminergic neurogenesis; Mesodermal commitment pathway; Ectoderm differentiation; let-7 inhibition of ES cell reprogramming; Pre-implantation embryo; Wnt signaling pathway and pluripotency; Sudden infant death syndrome (SIDS) susceptibility pathways",160.3,159.7,171.2,308.6,311.1,659.5,0.3839899937460912,-1.380859378110153,0.08740468155030068,1.0584653051572306,0.3189419957319759,0.49628829256683377,2003]
["P48553","Trafficking protein particle complex subunit 10 [OS=Homo sapiens]",3,4,7,4,1259,142.1,6.04,17.74,"transport","cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","TRAPPC10","ENSG00000160218","","COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs","",620.3,611.3,572.7,785.4,660.6,932,0.7587468460891506,-0.39830948040998004,0.0745929576734222,1.1273021723656944,0.29776074693339316,0.5261325547834179,1831]
["P48723","Heat shock 70 kDa protein 13 [OS=Homo sapiens]",22,9,30,9,471,51.9,5.76,85.01,"stress response;other biological processes","mitochondrion;ER/Golgi;other cell component","other molecular function","HSPA13","ENSG00000155304","","Regulation of HSF1-mediated heat shock response","",3120.7,2985.1,3106.3,3625.2,3624.9,6151.5,0.6873880730659024,-0.5408032752952119,0.1730434068361172,0.7618449432016415,0.42427851746567613,0.3723489573502993,2981]
["P48729-3","Isoform 3 of Casein kinase I isoform alpha [OS=Homo sapiens]",24,8,14,1,325,37.5,9.48,22.4,"","","","CSNK1A1","","","","",52.8,70.9,64.3,71.2,71.7,78.4,0.8495255309534568,-0.2352707892360119,0.12698820168576225,0.8962366269242903,0.3708177251782806,0.43083951464854053,2503]
["P49116-1","Nuclear receptor subfamily 2 group C member 2 [OS=Homo sapiens]",8,4,8,4,596,65.4,6.28,19.2,"developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NR2C2","ENSCANG00000032916; ENSG00000177463; ENSMLEG00000044042; ENSMMUG00000005156; ENSPPAG00000023138","","Nuclear Receptor transcription pathway","Androgen receptor signaling pathway; Nuclear receptors; Hypothesized pathways in pathogenesis of cardiovascular disease; Epithelial to mesenchymal transition in colorectal cancer; Androgen receptor signaling pathway; Nuclear receptors",719.5,739.7,751.1,819.6,786.9,727.9,0.9468385880740234,-0.07880959108712741,0.21866463105278547,0.6602214583012773,0.4643288170728672,0.33317436240884585,3442]
["P49137","MAP kinase-activated protein kinase 2 [OS=Homo sapiens]",17,7,14,5,400,45.5,8.68,31.3,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","MAPKAPK2","ENSG00000162889","MAPK signaling pathway; Cellular senescence; VEGF signaling pathway; C-type lectin receptor signaling pathway; Neurotrophin signaling pathway; Kaposi sarcoma-associated herpesvirus infection; Viral carcinogenesis","VEGFA-VEGFR2 Pathway; Oxidative Stress Induced Senescence; activated TAK1 mediates p38 MAPK activation; Regulation of HSF1-mediated heat shock response; p38MAPK events; CREB phosphorylation; Synthesis of Leukotrienes (LT) and Eoxins (EX); Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA","IL-1 signaling pathway; Microtubule cytoskeleton regulation; Interleukin-1 (IL-1) structural pathway; Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; VEGFA-VEGFR2 signaling pathway; p38 MAPK signaling pathway; Malignant pleural mesothelioma; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling",1290.7,1324.3,1292.4,1280.7,1331.5,1593.3,0.9291166329806206,-0.10606838389729058,0.36560381604166736,0.4369892799043174,0.5596226788373919,0.25210469394010965,4775]
["P49356","protein farnesyltransferase subunit beta [OS=Homo sapiens]",5,2,6,2,437,48.7,5.82,28.73,"protein metabolism;other metabolic processes","cytosol;cytoskeleton;other cell component","other molecular function","FNTB","ENSG00000257365","Terpenoid backbone biosynthesis","RAS processing; Potential therapeutics for SARS; Inactivation, recovery and regulation of the phototransduction cascade","",466.2,450.9,465.4,482.9,463.5,440.3,0.9969712266532054,-0.004376226937658932,0.9211148940914679,0.03568619525611004,0.9479623712918246,0.02320890133773377,7102]
["P49406","39S ribosomal protein L19, mitochondrial [OS=Homo sapiens]",34,9,28,9,292,33.5,9.5,78.73,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus","other molecular function","MRPL19","ENSG00000115364","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Cytoplasmic ribosomal proteins",3579.4,3530.4,3502,3326.3,3109,2288.6,1.2164055067114479,0.28262425262843394,0.11791474868062259,0.9284318703077096,0.361358028556256,0.44206229179986933,2385]
["P49454","Centromere protein F [OS=Homo sapiens]",19,55,69,54,3210,367.5,5.07,183.38,"","","","","","","","",5788.6,5618.1,5755.2,5651.7,5906.9,7448.6,0.9029157371943266,-0.14733673752910262,0.3365207842368012,0.4729881076640746,0.5460991145618961,0.2627285276233915,4504]
["P49642","DNA primase small subunit [OS=Homo sapiens]",20,5,8,5,420,49.9,8.21,27.68,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","PRIM1","ENSG00000198056","DNA replication","Activation of the pre-replicative complex; Removal of the Flap Intermediate; Polymerase switching on the C-strand of the telomere; Polymerase switching; Defective pyroptosis; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Telomere C-strand synthesis initiation; DNA replication initiation","Retinoblastoma gene in cancer; Pyrimidine metabolism; G1 to S cell cycle control; DNA replication",422.3,469.9,447.4,471.3,484.7,421.6,0.9724157955865272,-0.040354766690128385,0.6200551321896968,0.2075696934997197,0.7309649937378215,0.13610342111400062,6200]
["P49736","DNA replication licensing factor mcm2 [OS=Homo sapiens]",53,38,216,38,904,101.8,5.52,634.35,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MCM2","ENSG00000073111","DNA replication; Cell cycle","Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Assembly of the pre-replicative complex; Unwinding of DNA","Cell cycle; Ciliary landscape; G1 to S cell cycle control; DNA replication",20711.2,20747.4,20741.2,21544.8,21171.9,19868.8,0.9938372306684456,-8.918506415875431E-3,0.8127407583652226,0.09004796014473225,0.8746057424751785,0.05818767549665552,6792]
["P49750-4","Isoform 4 of YLP motif-containing protein 1 [OS=Homo sapiens]",19,36,59,35,2146,241.5,6.55,155.29,"other biological processes","cytosol;nucleus","","YLPM1","ENSG00000119596","","","",7297.1,7114.7,7165.2,7504.5,7360.1,8231.2,0.9342391257284872,-0.09813622873399201,0.13941169531891057,0.855700791521997,0.38847124707812325,0.4106411202283776,2623]
["P49770","Translation initiation factor eIF-2B subunit beta [OS=Homo sapiens]",27,8,18,8,351,39,6.16,55.22,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF2B2","ENSG00000119718","Herpes simplex virus 1 infection","Recycling of eIF2:GDP","Translation factors; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Rett syndrome causing genes",1317.7,1280.6,1262.7,1291.8,1320.8,2237.3,0.7960988886368792,-0.32898044642382446,0.34876117352917785,0.45747186967008446,0.5533091854405819,0.2570321200387911,4607]
["P49773","Histidine triad nucleotide-binding protein 1 [OS=Homo sapiens]",48,4,23,4,126,13.8,6.95,82.96,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","HINT1","ENSG00000169567","","","",3546,3483.9,3330.1,3644.3,3872.2,3459.9,0.9438431544039941,-0.08338095899078195,0.20378223593091682,0.6908336769214836,0.4508003518217527,0.34601575368585524,3304]
["P49840","Glycogen synthase kinase-3 alpha [OS=Homo sapiens]",35,10,22,7,483,50.9,8.75,54.73,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function","GSK3A","ENSG00000105723","Chemokine signaling pathway; Dopaminergic synapse; Non-alcoholic fatty liver disease; Shigellosis","XBP1(S) activates chaperone genes; Constitutive Signaling by AKT1 E17K in Cancer; AKT phosphorylates targets in the cytosol; Suppression of apoptosis; Maturation of nucleoprotein; Maturation of nucleoprotein","IL-5 signaling pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; Wnt signaling pathway; Regulation of apoptosis by parathyroid hormone-related protein; Angiopoietin-like protein 8 regulatory pathway; Nonalcoholic fatty liver disease; Insulin signaling; Glycogen synthesis and degradation",1612.4,1489.8,1550.1,1435.5,1391.3,1338.7,1.1168647221221941,0.15945445301690145,0.022826656414083248,1.6415576981137112,0.17397292151254898,0.7595183434004018,959]
["P49916-1","DNA ligase 3 [OS=Homo sapiens]",32,28,62,28,1009,112.8,9.01,209.66,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","LIG3","ENSG00000005156","Base excision repair","HDR through MMEJ (alt-NHEJ); Gap-filling DNA repair synthesis and ligation in TC-NER; Gap-filling DNA repair synthesis and ligation in GG-NER; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; Resolution of AP sites via the single-nucleotide replacement pathway","Base excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum",7310.4,7336.1,7433.9,7530.7,7751.9,9904.9,0.8766411910669976,-0.189941625981531,0.24368219903106186,0.6131761948404911,0.48464576672599485,0.3145755763767319,3675]
["P50336","protoporphyrinogen oxidase [OS=Homo sapiens]",31,11,24,11,477,50.7,8.16,62.92,"other metabolic processes;other biological processes","other membranes;mitochondrion","other molecular function","PPOX","ENSG00000143224","Porphyrin and chlorophyll metabolism; Metabolic pathways; Biosynthesis of cofactors","Heme biosynthesis","Orexin receptor pathway; Heme biosynthesis",1615,1714,1608.6,1556,1514.5,2134.4,0.9486445464850431,-0.07606047875317008,0.6833368619511992,0.1653651510463795,0.7789315539615277,0.10850070284451371,6412]
["P50443","sulfate transporter [OS=Homo sapiens]",1,1,1,1,739,81.6,8.38,2.85,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes","transporter activity","SLC26A2","ENSG00000155850","Chemical carcinogenesis","Transport and synthesis of PAPS; Multifunctional anion exchangers; Defective SLC26A2 causes chondrodysplasias","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Proteoglycan biosynthesis",39.6,42.3,43.2,45.2,45.3,71.4,0.772699197035207,-0.3720211961367461,0.23505827824257572,0.6288244492969911,0.4774988759519138,0.32102764642255066,3598]
["P50570-1","Dynamin-2 [OS=Homo sapiens]",44,37,151,2,870,98,7.44,464.51,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","DNM2","ENSG00000079805; ENSGGOG00000005968; ENSPTRG00000034439","Phospholipase D signaling pathway; Endocytosis; Fc gamma R-mediated phagocytosis; Synaptic vesicle cycle; Endocrine and other factor-regulated calcium reabsorption; Bacterial invasion of epithelial cells; Salmonella infection","MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Recycling pathway of L1; Clathrin-mediated endocytosis; NGF-stimulated transcription; Toll Like Receptor 4 (TLR4) Cascade; NOSTRIN mediated eNOS trafficking; Retrograde neurotrophin signalling; Formation of annular gap junctions","Synaptic vesicle pathway; Fragile X syndrome; Intracellular trafficking proteins involved in CMT neuropathy",18666.7,18500.9,18374.4,16611.5,16131.8,18262,1.0889456585884214,0.12293196136326075,0.08077466127190965,1.092724854517981,0.3086157863232554,0.5105818626613039,1913]
["P50579-2","Isoform 2 of Methionine aminopeptidase 2 [OS=Homo sapiens]",35,13,57,1,455,50.5,5.35,180.07,"","","","METAP2","","","","",71.2,71.8,77,83.8,88.2,93.6,0.8283132530120481,-0.27175162293490307,0.0108435419925859,1.964828834349881,0.11972122118400355,0.9218288619056079,662]
["P50897","Palmitoyl-protein thioesterase 1 [OS=Homo sapiens]",20,5,15,5,306,34.2,6.52,51.73,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PPT1","ENSG00000131238","Fatty acid elongation; Metabolic pathways; Fatty acid metabolism; Lysosome","Fatty acyl-CoA biosynthesis","",1455,1500.9,1478.7,1611.1,1493.8,1505.9,0.9617853734709814,-0.05621310855868298,0.2115674009347642,0.6745512491359897,0.45872030063251007,0.33845203977298877,3371]
["P50914","60S ribosomal protein L14 [OS=Homo sapiens]",29,6,40,6,215,23.4,10.93,109.32,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","other molecular function","RPL14","ENSG00000188846","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",4896.5,4997.3,4903.8,5218,5207.7,6522.8,0.8730920140425406,-0.19579438924852488,0.1768850355344515,0.7523089068286121,0.4276720888922613,0.36888909212245624,3023]
["P51151","Ras-related protein Rab-9A [OS=Homo sapiens]",47,7,8,7,201,22.8,5.47,21.06,"transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","RAB9A","ENSG00000123595","Salmonella infection; Measles","RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Retrograde transport at the Trans-Golgi-Network; RHOBTB3 ATPase cycle","Ebola virus pathway in host",766.9,768.6,795.6,673.1,749.6,1054.9,0.9408701969648045,-0.08793239330682882,0.6978218502536545,0.156255436011408,0.7892881311519593,0.10276442780906025,6462]
["P51532-4","Isoform 4 of Transcription activator BRG1 [OS=Homo sapiens]",22,35,82,18,1617,181.6,8.07,239.68,"","","","SMARCA4","","","","",4680.6,3567,3762.1,4220.1,4276.1,4964.5,0.8922047144650723,-0.16455332346561857,0.31215722047614575,0.5056266149960926,0.5336975729731344,0.27270477217631106,4275]
["P51571","translocon-associated protein subunit delta [OS=Homo sapiens]",36,5,27,5,173,19,6.15,88.66,"","other membranes;ER/Golgi;other cell component","","SSR4","ENSG00000180879","Protein processing in endoplasmic reticulum","SRP-dependent cotranslational protein targeting to membrane","VEGFA-VEGFR2 signaling pathway",3729.6,3675.7,3841.6,4479.7,3627.5,4815.3,0.8703346875604566,-0.2003577982577989,0.1926381376900958,0.7152577289003863,0.44096215107325715,0.3555986855558583,3193]
["P51648","Fatty aldehyde dehydrogenase [OS=Homo sapiens]",14,7,18,7,485,54.8,7.88,52.73,"other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ALDH3A2","ENSG00000072210","Glycolysis / Gluconeogenesis; Ascorbate and aldarate metabolism; Fatty acid degradation; Valine, leucine and isoleucine degradation; Lysine degradation; Arginine and proline metabolism; Histidine metabolism; Tryptophan metabolism; beta-Alanine metabolism; Glycerolipid metabolism; Pyruvate metabolism; Pantothenate and CoA biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Alcoholic liver disease","RND2 GTPase cycle; RND1 GTPase cycle","Fragile X syndrome; Tryptophan metabolism; Fluoroacetic acid toxicity",1723.6,1764.3,1810,1589.3,1572.7,1107,1.241016631529632,0.3115224499280134,0.09873963238599,1.0055084940198016,0.33442445463818393,0.47570197248272045,2158]
["P51692","Signal transducer and activator of transcription 5B [OS=Homo sapiens]",10,8,12,8,787,89.8,6.05,26.85,"other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","STAT5B","ENSG00000173757","ErbB signaling pathway; Chemokine signaling pathway; Necroptosis; JAK-STAT signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; Prolactin signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Hepatitis B; Measles; Human T-cell leukemia virus 1 infection; Pathways in cancer; Viral carcinogenesis; Chemical carcinogenesis; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer","Interleukin-3, Interleukin-5 and GM-CSF signaling; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Growth hormone receptor signaling; Signaling by Leptin; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Signaling by cytosolic FGFR1 fusion mutants; Prolactin receptor signaling; Interleukin-20 family signaling; Erythropoietin activates STAT5; Signaling by FLT3 fusion proteins; Interleukin-2 signaling; STAT5 activation downstream of FLT3 ITD mutants; Interleukin-15 signaling; Interleukin-9 signaling; Interleukin-21 signaling; STAT5 Activation","IL-5 signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; AGE/RAGE pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Chemokine signaling pathway; IL-4 signaling pathway; White fat cell differentiation; Non-small cell lung cancer; EGF/EGFR signaling pathway; Hepatitis B infection; Endochondral ossification; Endochondral ossification with skeletal dysplasias; IL-2 signaling pathway; 3q29 copy number variation syndrome; FOXP3 in COVID-19; Familial partial lipodystrophy (FPLD); EPO receptor signaling; ErbB signaling pathway",1182.8,1243.5,1240.3,1425.5,1253.5,2078.6,0.770682697158231,-0.3757910939680036,0.22260451323268823,0.6524660347354434,0.46672873987886354,0.33093545562544485,3486]
["P51795-2","Isoform 2 of H(+)/Cl(-) exchange transporter 5 [OS=Homo sapiens]",4,5,9,4,816,90.7,6.19,13.15,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","CLCN5","ENSG00000171365; ENSPPAG00000029912; ENSPTRG00000021899","Neutrophil extracellular trap formation","Stimuli-sensing channels","",723.8,725,739.9,820.8,782.3,1491.8,0.7071957090697599,-0.4998185737249843,0.26005537823710106,0.5849341600989458,0.4979682367133801,0.30279835816407163,3817]
["P51946","Cyclin-H [OS=Homo sapiens]",5,2,3,2,323,37.6,7.15,2.43,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","enzyme regulator activity","CCNH","ENSG00000134480","Basal transcription factors; Nucleotide excision repair; Cell cycle","RUNX1 regulates transcription of genes involved in differentiation of HSCs; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Formation of Incision Complex in GG-NER; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry","Cell cycle; Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum",262.3,245.9,274.8,285.1,349.3,195.6,0.9433734939759035,-0.08409902894324657,0.7471400570645411,0.12659797876187398,0.8271503600552454,0.08241553687219377,6602]
["P51948-1","CDK-activating kinase assembly factor MAT1 [OS=Homo sapiens]",20,4,5,4,309,35.8,6.09,14,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","nucleus","enzyme regulator activity;kinase activity;other molecular function","MNAT1","ENSCANG00000033478; ENSCATG00000030975; ENSCSAG00000014164; ENSG00000020426; ENSMFAG00000000901; ENSMMUG00000001642; ENSNLEG00000013781; ENSPPAG00000033622; ENSPTRG00000006412; ENSRROG00000035712","Basal transcription factors; Nucleotide excision repair","RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of Incision Complex in GG-NER; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry","Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; Eukaryotic transcription initiation; G1 to S cell cycle control",193.9,190.7,202.8,215.9,220.4,250.3,0.8555199533935335,-0.2251265916324052,0.04393316806631296,1.3572074781799564,0.22854628142112557,0.6410258405370821,1405]
["P52272","Heterogeneous nuclear ribonucleoprotein M [OS=Homo sapiens]",64,43,419,43,730,77.5,8.7,1152.55,"RNA metabolism OR transcription;other metabolic processes;stress response","nucleus;other cell component","nucleic acid binding activity;other molecular function","HNRNPM","ENSG00000099783","Spliceosome","mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA","mRNA processing",53087.3,51579.2,52767,52427.7,50947.1,50203.6,1.0251018372375282,0.035767239271734426,0.1828724537867536,0.7378517076967678,0.43102701216619865,0.3654955120501212,3101]
["P52429","Diacylglycerol kinase epsilon [OS=Homo sapiens]",8,6,11,6,567,63.9,7.74,27.76,"other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","DGKE","ENSG00000153933","Glycerolipid metabolism; Glycerophospholipid metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Phospholipase D signaling pathway; Choline metabolism in cancer","Effects of PIP2 hydrolysis","Ciliary landscape",1720.1,1782.3,1795.4,1676.9,1800.3,1397.8,1.086728205128205,0.11999116194334207,0.3098910474344781,0.5087909700852288,0.5325637586876559,0.2736283909152791,4253]
["P52565-1","rho GDP-dissociation inhibitor 1 [OS=Homo sapiens]",40,9,172,9,204,23.2,5.11,548.54,"signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","ARHGDIA; HEL-S-47e","ENSCATG00000044701; ENSG00000141522; ENSGGOG00000011564; ENSMLEG00000000660; ENSMMUG00000009949; ENSMNEG00000037888; ENSPPAG00000035710; ENSPPYG00000008748; ENSPTRG00000009773; ENSRBIG00000034513; ENSRROG00000034509","Neurotrophin signaling pathway; Vasopressin-regulated water reabsorption","CDC42 GTPase cycle; RAC1 GTPase cycle; RHOC GTPase cycle; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOH GTPase cycle; Axonal growth stimulation; Axonal growth inhibition (RHOA activation)","Ciliary landscape; Nephrotic syndrome",29703.8,30147.3,29597.2,28457.1,27496.4,17242,1.2220464372809805,0.2892991080388669,0.20607994692659715,0.6859642661675692,0.453686244604367,0.34324438798763257,3320]
["P52739","Zinc finger protein 131 [OS=Homo sapiens]",10,5,6,5,623,71.4,5.19,18.71,"other biological processes","cytoskeleton;nucleus","nucleic acid binding activity;other molecular function","ZNF131","ENSG00000172262","","SUMOylation of transcription cofactors","",295.2,308.4,300.3,293.3,339.5,332.8,{"$f":"AVERAGE(S2114:U2114)/AVERAGE(V2114:X2114)","v":0.9361019055509527},{"$f":"LOG(Y2114,2)","v":-0.0952625024394022},{"$f":"TTEST(S2114:U2114,V2114:X2114,2,2)","v":0.2400649846346079},{"$f":"-LOG10(AA2114)","v":0.6196711805883142},{"$f":"AA2114*7309/AE2114","v":0.4819101820088847},{"$f":"-LOG10(AC2114)","v":0.317033897638285},3641]
["P52815","39S ribosomal protein L12, mitochondrial [OS=Homo sapiens]",39,5,53,5,198,21.3,8.87,149.17,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL12","ENSG00000262814","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",3742,3946.3,3476.6,3429.4,4231.8,3108.5,1.0366955439798693,0.05199226668582194,0.7334174531771153,0.1346487593217981,0.8175306032135939,0.08749598110434045,6557]
["P52907","F-actin-capping protein subunit alpha-1 [OS=Homo sapiens]",69,14,178,11,286,32.9,5.69,709.15,"cell organization and biogenesis","non-structural extracellular;cytosol;cytoskeleton;other cell component","cytoskeletal activity","CAPZA1","ENSG00000116489","Endocytosis","MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Sensory processing of sound by inner hair cells of the cochlea; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Factors involved in megakaryocyte development and platelet production; Advanced glycosylation endproduct receptor signaling","",15487.8,15535.9,15740.7,15009.1,14704.6,16070,1.021420287132757,0.030576618808710484,0.480847028396933,0.31799306352097195,0.6329031029269193,0.1986627751095656,5553]
["P53365","Arfaptin-2 [OS=Homo sapiens]",23,4,6,3,341,37.8,6.04,24.62,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","ARFIP2","ENSG00000132254","","Retrograde transport at the Trans-Golgi-Network","",538,528.9,539.2,423.4,474.8,216.9,1.4403192538785758,0.5263886275967921,0.10662774379002052,0.972129780232076,0.34499432463977864,0.4621880492684661,2259]
["P53370","Nucleoside diphosphate-linked moiety X motif 6 [OS=Homo sapiens]",3,1,2,1,316,35.7,8,4.1,"other biological processes","mitochondrion;nucleus;other cell component","other molecular function","NUDT6","ENSG00000170917","","","",128.5,151.2,153.6,128.2,127.2,96.3,1.232015922661359,0.30102090164656164,0.10789976666403535,0.9669794944888358,0.34650237018780067,0.46029379032789647,2276]
["P53621-1","coatomer subunit alpha [OS=Homo sapiens]",54,57,294,57,1224,138.3,7.66,894.15,"transport;signal transduction","non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","COPA","ENSG00000122218","","COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic","",33891.4,33130.2,33739.4,32776.4,32277.1,28380.5,1.0784189909454802,0.10891780769845526,0.15803548185756727,0.8012453950395401,0.410330847920767,0.3868658323429322,2815]
["P53701","Cytochrome c-type heme lyase [OS=Homo sapiens]",65,16,41,16,268,30.6,6.68,118.25,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes","other membranes;mitochondrion","other molecular function","HCCS","ENSG00000004961","Porphyrin and chlorophyll metabolism; Metabolic pathways","","",3934.1,3946.9,3912.7,4182.2,4152.7,4524.2,0.9171481674456224,-0.12477327145815621,0.041209497364167576,1.3850026825707693,0.22163371319698366,0.6543641774192906,1359]
["P53801","pituitary tumor-transforming gene 1 protein-interacting protein [OS=Homo sapiens]",8,2,6,2,180,20.3,8.79,13.57,"transport;other biological processes","other membranes;nucleus;other cell component","other molecular function","PTTG1IP","ENSG00000183255","","","",957.3,1021.4,1028.9,781.5,865.6,472.3,1.41908087194489,0.5049568094331538,0.0717874207393709,1.143951650215884,0.291821055719723,0.5348833757291208,1798]
["P54105","Methylosome subunit pICln [OS=Homo sapiens]",35,5,13,5,237,26.2,4.11,50.27,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","","CLNS1A","ENSG00000074201","","snRNP Assembly","",576.6,519.1,567.9,615,667.2,974.6,0.737149946827366,-0.43996998093921563,0.15673022228549308,0.8048472504602151,0.4085382292028063,0.3887672978708632,2804]
["P54274-1","telomeric repeat-binding factor 1 [OS=Homo sapiens]",3,1,1,1,439,50.2,6.37,2.11,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","TERF1","ENSG00000147601","","Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Meiotic synapsis; Inhibition of DNA recombination at telomere; Packaging Of Telomere Ends; DNA Damage/Telomere Stress Induced Senescence; Telomere Extension By Telomerase; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; Removal of the Flap Intermediate from the C-strand","",61.4,61,62.8,87.5,86.9,61.5,0.7850784230606188,-0.3490913199792264,0.12039386481969194,0.9193956438326953,0.36452309774943187,0.4382749477100527,2414]
["P54296","Myomesin-2 [OS=Homo sapiens]",6,7,9,7,1465,164.8,6.19,23.9,"cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYOM2","ENSG00000036448; ENSG00000274137","","","",320.3,318.6,309.2,390.1,376,386.4,0.8226464208242951,-0.28165561142321655,2.3591311511564665E-4,3.627247914714116,0.019158766204225127,1.717632462269468,90]
["P54802","alpha-N-acetylglucosaminidase [OS=Homo sapiens]",19,10,20,10,743,82.2,6.65,57.38,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;other cytoplasmic organelle","other molecular function","NAGLU","ENSG00000108784","Glycosaminoglycan degradation; Metabolic pathways; Lysosome","HS-GAG degradation; MPS IIIB - Sanfilippo syndrome B","Glycosaminoglycan degradation",1699,1623.1,1668.3,1615,1596.3,1945.3,0.9677694604972267,-0.047264681488287906,0.6564371868550607,0.18280682434579185,0.7591612972663986,0.11966594074420385,6320]
["P54852","Epithelial membrane protein 3 [OS=Homo sapiens]",10,1,3,1,163,18.4,7.96,10.84,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes","","EMP3","ENSG00000142227","","","",186,183,215.1,182.8,180.6,253.8,0.9463707064160726,-0.07952267712928407,0.6945555118755707,0.15829303784891846,0.7872993542646629,0.10386010476197975,6448]
["P55039","Developmentally-regulated GTP-binding protein 2 [OS=Homo sapiens]",35,11,41,10,364,40.7,8.88,108.5,"protein metabolism;other metabolic processes;signal transduction","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DRG2","ENSG00000108591","","","",3907.9,3947.7,4045.4,3781.7,3744.8,3507.2,1.0786046385165446,0.1091661432541078,0.03854751647204509,1.414003597307733,0.21507160144593704,0.6674169310795243,1310]
["P55145","Mesencephalic astrocyte-derived neurotrophic factor [OS=Homo sapiens]",25,6,18,6,182,20.7,8.69,39.71,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","MANF","ENSG00000145050","","Platelet degranulation","Orexin receptor pathway",1550.9,1575.5,1334.8,1561.8,1638.9,1445.8,0.9601205208221242,-0.05871258084630212,0.5504230204093689,0.25930341084142056,0.6834933496724562,0.1652657067210397,5886]
["P55197-1","Isoform 1 of Protein AF-10 [OS=Homo sapiens]",3,3,3,2,1027,109,8.38,6.62,"","","","MLLT10","","","","",228.7,205.7,239.9,299.4,316.5,265,0.7654671358837553,-0.3855876556538912,0.019316610803629133,1.7140690703843628,0.16043762314059698,0.7946937806505586,880]
["P55209-3","Isoform 3 of Nucleosome assembly protein 1-like 1 [OS=Homo sapiens]",47,11,262,1,323,37.3,4.67,864.92,"","","","NAP1L1","","","","",17,25.9,18.1,12.9,18.7,41.5,0.8344733242134064,-0.26106216350218864,0.6826863208009164,0.16577879915534957,0.7786757675926806,0.1086433403475579,6408]
["P55769","NHP2-like protein 1 [OS=Homo sapiens]",38,5,20,5,128,14.2,8.46,56.04,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SNU13","ENSG00000100138","Ribosome biogenesis in eukaryotes; Spliceosome","mRNA Splicing - Major Pathway; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; mRNA Splicing - Minor Pathway","mRNA processing",2592.2,2708.8,2408.2,2783.5,3096.2,2835.1,0.8846100885849361,-0.17688639926117208,0.06203999170048592,1.2073282689569724,0.26958995204450154,0.5692962985348928,1682]
["P55795","heterogeneous nuclear ribonucleoprotein H2 [OS=Homo sapiens]",48,18,271,7,449,49.2,6.3,653.89,"other biological processes","cytosol;nucleus;other cell component","","HNRNPH2","ENSG00000126945","","mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA","mRNA processing",6861.1,6995,7189,6924.6,7277,5944.9,1.0446032809669172,0.06295514015275931,0.5052510368999554,0.2964927865321698,0.6493546384212721,0.18751805290036444,5687]
["P56181-2","Isoform 2 of NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [OS=Homo sapiens]",22,7,14,7,473,51,9.17,48.09,"","","","NDUFV3","","","","",928.2,820.9,2062.1,2229,1452.9,1493.4,0.736421077039012,-0.4413971763683281,0.3884663203480103,0.4106466281399309,0.5725550182342423,0.24218277454706788,4959]
["P56270-2","Isoform 2 of Myc-associated zinc finger protein [OS=Homo sapiens]",10,5,11,4,493,51,9.1,40.42,"","","","MAZ","","","","",888.5,819.1,793.6,943.9,1055.7,1098.9,0.8072293045021784,-0.30894954594783824,0.02131729752990762,1.6712678532214749,0.16825931711241338,0.7740208780194362,926]
["P56937-1","3-keto-steroid reductase [OS=Homo sapiens]",21,6,13,6,341,38.2,8.1,39.26,"other metabolic processes","other membranes;ER/Golgi","other molecular function","HSD17B7","ENSG00000132196","Steroid biosynthesis; Steroid hormone biosynthesis; Metabolic pathways; Ovarian steroidogenesis","Cholesterol biosynthesis","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Steroid biosynthesis",1099.8,1072.9,1075.2,1161.9,1221.3,1879.9,0.7618634327132836,-0.39239568326459395,0.21555589273789913,0.6664401001653617,0.4620228797716436,0.33533651727388647,3410]
["P57678","Gem-associated protein 4 [OS=Homo sapiens]",10,10,21,10,1058,120,6.04,54.82,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","GEMIN4","ENSG00000179409","","snRNP Assembly","",2078.3,2030.3,2073.5,2318.4,2202.4,2392.4,0.8942457906613436,-0.16125667261603438,0.013173562732241864,1.8802967561158612,0.13135821283759316,0.8815427688730162,733]
["P57737","Coronin-7 [OS=Homo sapiens]",52,34,178,1,925,100.5,5.8,561.51,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cell component","cytoskeletal activity","CORO7","ENSG00000262246; ENSG00000282725","","","",318,312.5,326.8,305.9,301.9,474.4,0.8845869525041582,-0.1769241319819833,0.5056005632084748,0.29619245094759283,0.6496896126038576,0.18729407678532978,5688]
["P58005-1","sestrin-3 [OS=Homo sapiens]",5,2,3,2,492,57.3,6.25,5.58,"stress response;signal transduction;other biological processes","nucleus;other cell component","other molecular function","SESN3","ENSG00000149212","p53 signaling pathway; Longevity regulating pathway","TP53 Regulates Metabolic Genes","Angiopoietin-like protein 8 regulatory pathway; miRNA regulation of p53 pathway in prostate cancer",157.9,164.5,160.7,97.3,104.8,164.7,1.3170665212649948,0.39732821383702277,0.14446752320317935,0.8402297728306146,0.39562125406220977,0.4027203847341493,2669]
["P60468","protein transport protein Sec61 subunit beta [OS=Homo sapiens]",36,4,39,4,96,10,11.56,58.02,"protein metabolism;other metabolic processes;stress response;transport","other membranes;cytosol;ER/Golgi","translation activity;other molecular function","SEC61B","ENSG00000106803","Protein export; Protein processing in endoplasmic reticulum; Phagosome; Vibrio cholerae infection","ER-Phagosome pathway; SRP-dependent cotranslational protein targeting to membrane; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",4370.4,4487.3,4472.6,4022.2,4432.7,3268.9,1.1370289496579609,0.18526898685661586,0.19324618301439447,0.7138890754803088,0.4411106657252371,0.3554524411796167,3202]
["P60520","Gamma-aminobutyric acid receptor-associated protein-like 2 [OS=Homo sapiens]",35,5,6,5,117,13.7,8.1,15.85,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","GABARAPL2","ENSG00000034713","FoxO signaling pathway; Autophagy; Mitophagy; Autophagy; NOD-like receptor signaling pathway; GABAergic synapse","TBC/RABGAPs; Macroautophagy","Network map of SARS-CoV-2 signaling pathway; Senescence and autophagy in cancer",716.3,681.3,706.6,1131.2,1150,1962.8,0.49580584354382656,-1.0121528198281586,0.06003946090489649,1.2215632159470848,0.2662793809186216,0.5746624614242088,1648]
["P60891","ribose-phosphate pyrophosphokinase 1 [OS=Homo sapiens]",58,17,100,8,318,34.8,6.98,299.06,"other metabolic processes;developmental processes","cytosol;other cell component","kinase activity;other molecular function","PRPS1","ENSG00000147224","Pentose phosphate pathway; Purine metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids","5-Phosphoribose 1-diphosphate biosynthesis","Nucleotide metabolism",13866.7,14208.5,14001.4,12683.6,11950.9,10499,1.1976205046465624,0.2601708273261607,0.023525662661047123,1.6284581347027065,0.1761773241696654,0.7540499904854254,976]
["P60953","Cell division control protein 42 homolog [OS=Homo sapiens]",48,8,143,2,191,21.2,6.55,517.75,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","CDC42","ENSG00000070831","MAPK signaling pathway; Ras signaling pathway; Rap1 signaling pathway; Chemokine signaling pathway; Endocytosis; Axon guidance; VEGF signaling pathway; Focal adhesion; Adherens junction; Tight junction; T cell receptor signaling pathway; Fc gamma R-mediated phagocytosis; Leukocyte transendothelial migration; Neurotrophin signaling pathway; Regulation of actin cytoskeleton; GnRH signaling pathway; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Bacterial invasion of epithelial cells; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Human papillomavirus infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; Renal cell carcinoma; Pancreatic cancer; Lipid and atherosclerosis","RHO GTPases Activate Formins; MAPK6/MAPK4 signaling; RHO GTPases activate IQGAPs; RAC1 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; GPVI-mediated activation cascade; CDC42 GTPase cycle; RHOG GTPase cycle; RAC3 GTPase cycle; RHOQ GTPase cycle; RAC2 GTPase cycle; RHOJ GTPase cycle; EPHB-mediated forward signaling; DCC mediated attractive signaling; Myogenesis; G beta:gamma signalling through CDC42; EGFR downregulation; RHO GTPases activate PAKs; Inactivation of CDC42 and RAC1; CD28 dependent Vav1 pathway; RHO GTPases activate KTN1","Androgen receptor signaling pathway; Target of rapamycin (TOR) signaling; Integrin-mediated cell adhesion; Integrated breast cancer pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; Microtubule cytoskeleton regulation; Metastatic brain tumor; Pathogenic Escherichia coli infection; RalA downstream regulated genes; B cell receptor signaling pathway; AGE/RAGE pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Focal adhesion; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; Oxidative damage response; p38 MAPK signaling pathway; Ebola virus pathway in host; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Hippo signaling regulation pathways; 22q11.2 copy number variation syndrome; Gastrin signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent)",12763.6,13565.4,13154.8,11551.8,12429.2,6408.7,1.299249416743173,0.3776784113537694,0.18436563695382036,0.7343200218508725,0.43231582948202535,0.36419886224373943,3117]
["P61020","Ras-related protein Rab-5B [OS=Homo sapiens]",66,9,33,6,215,23.7,8.13,109.45,"transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","RAB5B","ENSG00000111540","Ras signaling pathway; Endocytosis; Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection; Amoebiasis; Tuberculosis","RAB geranylgeranylation; Neutrophil degranulation; Clathrin-mediated endocytosis; RAB GEFs exchange GTP for GDP on RABs; TBC/RABGAPs","Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells",1224.1,1252.1,1228.7,1114.8,1176.2,1743.8,0.9182363438088627,-0.12306255981470329,0.6123890432369032,0.2129725882290362,0.7249678518008627,0.13968125149113977,6174]
["P61160-1","Actin-related protein 2 [OS=Homo sapiens]",36,11,110,11,394,44.7,6.74,332.6,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","Actr2; ACTR2; LOC111147990","ENSAMEG00000015749; ENSANAG00000038066; ENSBIXG00000015264; ENSBIXG00005008678; ENSBTAG00000009761; ENSCAFG00000003197; ENSCATG00000036025; ENSCCAG00000030047; ENSCHIG00000014272; ENSCJAG00000006722; ENSCPOG00000025808; ENSDLEG00000013424; ENSECAG00000009219; ENSFCAG00000004960; ENSG00000138071; ENSHGLG00000013085; ENSLAFG00000010273; ENSLCNG00005006073; ENSMFAG00000044097; ENSMLEG00000038155; ENSMLUG00000005227; ENSMMUG00000002263; ENSMNEG00000044163; ENSMPUG00000006176; ENSMUSG00000020152; ENSNLEG00000009948; ENSOANG00000039143; ENSOCUG00000004906; ENSPANG00000007073; ENSPCOG00000025808; ENSPCTG00005007920; ENSPPAG00000030634; ENSPPYG00000012359; ENSPTRG00000011990; ENSRBIG00000040326; ENSRFEG00010007536; ENSRROG00000043956; ENSSBOG00000028028; ENSSSUG00005000856; ENSSTOG00000012608; ENSTSYG00000034470; ENSVURG00010013014; ENSVVUG00000027598","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Salmonella infection; Yersinia infection; Pathogenic Escherichia coli infection; Shigellosis","Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; EPHB-mediated forward signaling; Regulation of actin dynamics for phagocytic cup formation; Neutrophil degranulation; EPHB-mediated forward signaling; Clathrin-mediated endocytosis; RHO GTPases Activate WASPs and WAVEs","ESC pluripotency pathways; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways",14079.1,14426.9,14527.6,13217.8,13253.1,13396.9,1.0794074415944697,0.11023953861035779,0.001968268788341783,2.7059155942569753,0.05065519920419047,1.2953759724200398,284]
["P61201-1","COP9 signalosome complex subunit 2 [OS=Homo sapiens]",44,17,60,1,443,51.6,5.53,181.37,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","Cops2; COPS2; LOC101356833; LOC111162519","ENSACCG00020011181; ENSANAG00000033255; ENSBIXG00000019496; ENSBIXG00005014970; ENSCHIG00000021490; ENSCPOG00000003447; ENSCSAG00000010648; ENSDLEG00000002228; ENSG00000166200; ENSGALG00000000404; ENSLSDG00000017105; ENSMMUG00000009838; ENSMPUG00000012327; ENSMUSG00000027206; ENSOARG00000021006; ENSPPYG00000006460; ENSPSIG00000010252; ENSRNOG00000008744; ENSSHBG00005020299; ENSSSCG00000004652; ENSSSCG00070002171; ENSSTOG00000005348; ENSUMAG00000014609","","Cargo recognition for clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER; Formation of TC-NER Pre-Incision Complex; RHOBTB1 GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; Neddylation; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER; RHOBTB1 GTPase cycle; Neddylation; DNA Damage Recognition in GG-NER; Formation of TC-NER Pre-Incision Complex; Cargo recognition for clathrin-mediated endocytosis; RHOBTB1 GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; Neddylation; Formation of TC-NER Pre-Incision Complex; RHOBTB1 GTPase cycle; DNA Damage Recognition in GG-NER","Ciliary landscape",5549,5500.7,5480.7,5809.3,5670.5,4886.1,1.0100513873358632,0.0144286933421252,0.8583316296195453,0.06634488337845014,0.9047513528827887,0.043470758814855036,6934]
["P61313-1","60S ribosomal protein L15 [OS=Homo sapiens]",50,12,68,12,204,24.1,11.62,207.71,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;cytoskeleton;translational apparatus;nucleus","nucleic acid binding activity;other molecular function","LOC111155115; NR1D2; Rpl15; RPL15","ENSAMEG00000003497; ENSAMEG00000024645; ENSBIXG00000012476; ENSBIXG00005007092; ENSBMUG00000012295; ENSBTAG00000033080; ENSCAFG00000005764; ENSCAFG00030022972; ENSCAFG00040022162; ENSCANG00000040764; ENSCATG00000039291; ENSCGRG00001021972; ENSCGRG00015016653; ENSCJAG00000043224; ENSCPOG00000030042; ENSCSAG00000009762; ENSECAG00000010157; ENSFCAG00000026237; ENSG00000174748; ENSGGOG00000024274; ENSHGLG00000000795; ENSLCNG00005011910; ENSMFAG00000043886; ENSMLEG00000031741; ENSMLUG00000013809; ENSMMUG00000006353; ENSMPUG00000012148; ENSMUSG00000012405; ENSNLEG00000003580; ENSOANG00000045456; ENSOCUG00000010961; ENSOGAG00000013056; ENSPANG00000015926; ENSPPAG00000032386; ENSPPYG00000014065; ENSPTRG00000014695; ENSRBIG00000024014; ENSRBIG00000033415; ENSRFEG00010011144; ENSRNOG00000008140; ENSRROG00000001983; ENSRROG00000015533; ENSRROG00000027506; ENSRROG00000028991; ENSRROG00000037650; ENSSHAG00000031281; ENSSSCG00000037030; ENSSSCG00070018008; ENSSSUG00005002593; ENSSTOG00000011153; ENSUAMG00000015536; ENSVURG00010022414; ENSVVUG00000028235","Ribosome; Coronavirus disease","L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Formation of a pool of free 40S subunits; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins; Cytoplasmic ribosomal proteins; Cytoplasmic ribosomal proteins",11506.2,12151.2,11228.5,12974.8,14214.9,14247.5,0.8418981012230556,-0.2482824670070789,0.012005740875794495,1.9206110344123475,0.1257162751592865,0.9006084951515356,698]
["P61626","lysozyme c [OS=Homo sapiens]",6,1,1,1,148,16.5,9.16,2.6,"other metabolic processes;stress response;other biological processes","non-structural extracellular;other cytoplasmic organelle;other cell component","other molecular function","LYZ","ENSG00000090382","Salivary secretion","Neutrophil degranulation; Amyloid fiber formation; Antimicrobial peptides","Macrophage markers",143.6,84.1,120.8,182,101.8,59.1,1.016331291921843,0.023370751820150932,0.9649956583302743,0.015474640612109838,0.9774325480509943,0.009913203262022195,7216]
["P61769","Beta-2-microglobulin [OS=Homo sapiens]",8,1,2,1,119,13.7,6.52,6.3,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","B2M","ENSG00000166710; ENSG00000273686","Antigen processing and presentation; Human cytomegalovirus infection; Human T-cell leukemia virus 1 infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection","ER-Phagosome pathway; Neutrophil degranulation; DAP12 signaling; Amyloid fiber formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Modulation by Mtb of host immune system; Nef mediated downregulation of MHC class I complex cell surface expression; Endosomal/Vacuolar pathway","IL-18 signaling pathway",198.3,168.6,153.7,195.3,155.6,152.7,1.0337569499602859,0.04789702868509561,0.780277094423168,0.10775114191393213,0.8496789754378627,0.07074512785060301,6712]
["P61962","DDB1- and CUL4-associated factor 7 [OS=Homo sapiens]",17,5,9,5,342,38.9,5.52,25.48,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","DCAF7","ENSG00000136485","","Neddylation; Association of TriC/CCT with target proteins during biosynthesis","Ciliary landscape",1020.4,1040,945.8,945.7,1042,1795.7,0.7945763070254267,-0.33174231964224365,0.3920413483903558,0.4066681257582256,0.5742345121012247,0.24091070949764248,4990]
["P61970","nuclear transport factor 2 [OS=Homo sapiens]",74,6,40,6,127,14.5,5.38,113.91,"transport;other biological processes","other membranes;cytosol;nucleus","other molecular function","NUTF2","ENSG00000102898","","","",6482.2,6520.2,6327.2,5978.4,6305.2,5754.3,1.0716103315796186,0.0997803956311414,0.06498156106633768,1.1872098597138299,0.275973404900559,0.5591327681574173,1721]
["P62136-1","serine/threonine-protein phosphatase PP1-alpha catalytic subunit [OS=Homo sapiens]",59,15,107,4,330,37.5,6.33,384.55,"cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","LOC111149674; Ppp1ca; PPP1CA","ENSAMEG00000000758; ENSANAG00000023829; ENSBIXG00000010347; ENSBIXG00005003445; ENSBTAG00000012146; ENSCAFG00000041420; ENSCATG00000031120; ENSCCAG00000020614; ENSCHIG00000012800; ENSCJAG00000000983; ENSCPOG00000032835; ENSCSAG00000008548; ENSECAG00000010532; ENSFCAG00000028502; ENSG00000172531; ENSGGOG00000009981; ENSHGLG00000013028; ENSLCNG00005013643; ENSMLUG00000005112; ENSMMUG00000017278; ENSMNEG00000042253; ENSMPUG00000003801; ENSNLEG00000006360; ENSOARG00000011318; ENSOGAG00000033516; ENSPANG00000009836; ENSPCOG00000026258; ENSPCTG00005022585; ENSPPYG00000002995; ENSRFEG00010000614; ENSRNOG00000018708; ENSSHAG00000030720; ENSSSCG00000012913; ENSSSCG00070006658; ENSVURG00010024750; ENSVVUG00000010423","mRNA surveillance pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Oocyte meiosis; Cellular senescence; Adrenergic signaling in cardiomyocytes; Vascular smooth muscle contraction; Hippo signaling pathway; Focal adhesion; Platelet activation; Long-term potentiation; Dopaminergic synapse; Inflammatory mediator regulation of TRP channels; Regulation of actin cytoskeleton; Insulin signaling pathway; Oxytocin signaling pathway; Insulin resistance; Amphetamine addiction; Alcoholism; Herpes simplex virus 1 infection; Proteoglycans in cancer; Diabetic cardiomyopathy","DARPP-32 events; Circadian Clock; Triglyceride catabolism; Downregulation of TGF-beta receptor signaling; DARPP-32 events; DARPP-32 events","Sphingolipid pathway; Nicotine effect on dopaminergic neurons; Common pathways underlying drug addiction; Vascular smooth muscle contraction; Focal adhesion; VEGFA-VEGFR2 signaling pathway; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Netrin-UNC5B signaling pathway; Neuroinflammation and glutamatergic signaling",3213.6,3174.6,3159,3137.1,3261,2542.7,1.0678239083750896,0.09467375614543712,0.41459889784472714,0.3823718567539511,0.5855658636419538,0.2324242489989334,5175]
["P62256","ubiquitin-conjugating enzyme E2 H [OS=Homo sapiens]",28,6,8,6,183,20.6,4.67,23.56,"protein metabolism;other metabolic processes","cytosol;nucleus","other molecular function","UBE2H","ENSG00000186591","Ubiquitin mediated proteolysis","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation","Ciliary landscape",1628.6,1592,1546,1962.5,1783.9,832,1.0411060632535385,0.058117051476229024,0.8670961377825617,0.061932748205696234,0.9096606388765242,0.041120596856292525,6967]
["P62266","40S ribosomal protein S23 [OS=Homo sapiens]",52,7,57,7,143,15.8,10.49,177.3,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytosol;ER/Golgi;translational apparatus;nucleus;other cell component","other molecular function","RPS23","ENSG00000186468","Ribosome; Coronavirus disease","Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",7996.4,8225.2,7960.4,8889.7,8621.3,8194.3,0.9407398474244613,-0.08813228024546083,0.08107437802887904,1.0911163743806986,0.30927590240766023,0.5096539172392511,1916]
["P62312","U6 snRNA-associated Sm-like protein LSm6 [OS=Homo sapiens]",43,4,6,4,80,9.1,9.58,13.28,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","LSM6","ENSG00000164167","RNA degradation; Spliceosome","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease","",1368.9,1487.8,1336.1,1337.1,1379.1,1448.8,1.006674669867947,0.009597518497643072,0.877532715747283,0.056736683404975716,0.9170555646835704,0.03760434949422869,6994]
["P62487","DNA-directed RNA polymerase II subunit rpb7 [OS=Homo sapiens]",38,5,9,5,172,19.3,5.54,24.31,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POLR2G","ENSG00000168002","RNA polymerase; Huntington disease","FGFR2 alternative splicing; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere","Pyrimidine metabolism; Eukaryotic transcription initiation",818,805.3,827.7,996.7,965.9,1294.6,0.7524867984772197,-0.41026182323231775,0.06269899164085538,1.202739443672214,0.27084333918617726,0.5672818404912459,1692]
["P62633-1","Cellular nucleic acid-binding protein [OS=Homo sapiens]",50,9,54,1,177,19.5,7.71,136.79,"DNA metabolism;other metabolic processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","Cnbp; CNBP; LOC101344172; LOC111159043; LOC113917796","ENSAMEG00000015334; ENSBIXG00000009042; ENSBMUG00000014129; ENSCAFG00000004320; ENSCANG00000042967; ENSCATG00000020089; ENSCCAG00000034056; ENSCGRG00001000923; ENSCJAG00000017430; ENSCPOG00000032294; ENSCSAG00000008817; ENSDLEG00000010302; ENSECAG00000009512; ENSFCAG00000042197; ENSG00000169714; ENSHGLG00000002069; ENSLAFG00000002502; ENSLCNG00005005148; ENSMFAG00000030262; ENSMLEG00000041892; ENSMMUG00000058753; ENSMNEG00000028473; ENSMPUG00000017315; ENSNLEG00000035879; ENSOCUG00000008696; ENSPANG00000007815; ENSPCTG00005021559; ENSPPYG00000013423; ENSPTRG00000015369; ENSRBIG00000030361; ENSRNOG00000010239; ENSRROG00000045469; ENSSBOG00000023735; ENSSSCG00070013675; ENSSTOG00000000173; ENSTSYG00000004344; ENSTTRG00000015266; ENSVVUG00000018264","","","",5257.4,4785.8,4675.1,8275.2,7904.2,6269.5,0.6556356881628944,-0.6090337082134084,0.01590134286600344,1.7985661980274108,0.1447358841937972,0.8394237814221187,803]
["P62753","40S RIBOSOMAL PROTEIN S6 [OS=Homo sapiens]",43,13,163,13,249,28.7,10.84,526.71,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;ER/Golgi;translational apparatus;nucleus;other cell component","other molecular function","RPS6","ENSG00000137154","EGFR tyrosine kinase inhibitor resistance; Ribosome; HIF-1 signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Apelin signaling pathway; Thermogenesis; Insulin signaling pathway; Coronavirus disease; Proteoglycans in cancer","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); mTORC1-mediated signalling; rRNA modification in the nucleus and cytosol; Nuclear events stimulated by ALK signaling in cancer","IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Thermogenesis; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Cytoplasmic ribosomal proteins; EGFR tyrosine kinase inhibitor resistance; IL-2 signaling pathway; Malignant pleural mesothelioma; Interferon type I signaling pathways",16836.8,18613.4,19014.1,18514.7,17848.3,17554.3,1.0101451667646562,0.014562635870320856,0.8142934499449923,0.08921905859312251,0.8756320178973,0.05767836663141127,6797]
["P62826","GTP-binding nuclear protein RAN [OS=Homo sapiens]",66,10,91,10,216,24.4,7.49,277.36,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;other biological processes","cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RAN","ENSG00000132341","Ribosome biogenesis in eukaryotes; Nucleocytoplasmic transport; Human T-cell leukemia virus 1 infection","Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Nuclear import of Rev protein; Transcriptional regulation by small RNAs; tRNA processing in the nucleus; Regulation of cholesterol biosynthesis by SREBP (SREBF); MicroRNA (miRNA) biogenesis; Postmitotic nuclear pore complex (NPC) reformation","Androgen receptor signaling pathway; miRNA biogenesis; 22q11.2 copy number variation syndrome",12762,12807.5,12838.1,11756.3,11128.9,11932.9,1.1030929315499698,0.14155433783645022,0.00813350055088858,2.0897224995799086,0.10466154141979689,0.9802128734069546,568]
["P62854","40S ribosomal protein S26 [OS=Homo sapiens]",21,2,7,2,115,13,11,24.57,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;translational apparatus;nucleus","nucleic acid binding activity;other molecular function","RPS26","ENSG00000197728","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Peptide chain elongation; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",617.1,725.7,763.5,719.6,669.4,815.8,0.9553247460087082,-0.06593685931335048,0.6211777033598238,0.20678414129115846,0.7318162208022166,0.13559796854875286,6204]
["P62913","60S ribosomal protein L11 [OS=Homo sapiens]",49,8,53,8,178,20.2,9.6,142.44,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;translational apparatus;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","RPL11","ENSG00000142676","Ribosome; Coronavirus disease","Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",9162,9294.4,8707.5,9705.4,9531.4,4948.7,1.1231481672903185,0.16754826265798867,0.5608969999968092,0.2511168828436046,0.6910984782496087,0.160460063315976,5932]
["P62937-2","Isoform 2 of Peptidyl-prolyl cis-trans isomerase A [OS=Homo sapiens]",90,12,899,1,105,11.4,7.9,1952.98,"","","","PPIA","","","","",663,676,722.2,461.9,292.7,159.7,2.2544022749644537,1.1727449726146406,0.012822985990271199,1.8920108322198337,0.129630988385743,0.8872911676303916,723]
["P63027","Vesicle-associated membrane protein 2 [OS=Homo sapiens]",34,4,16,1,116,12.7,8.13,54.84,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","VAMP2","ENSG00000220205","SNARE interactions in vesicular transport; Synaptic vesicle cycle; Insulin secretion; Vasopressin-regulated water reabsorption; Salivary secretion","Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; GABA synthesis, release, reuptake and degradation; Cargo recognition for clathrin-mediated endocytosis; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Sensory processing of sound by inner hair cells of the cochlea; Lysosome Vesicle Biogenesis; trans-Golgi Network Vesicle Budding; Golgi Associated Vesicle Biogenesis; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; Regulation of insulin secretion; Insulin processing; Other interleukin signaling; Toxicity of tetanus toxin (tetX); Toxicity of botulinum toxin type B (botB); Toxicity of botulinum toxin type D (botD); Toxicity of botulinum toxin type G (botG); Toxicity of botulinum toxin type F (botF)","Synaptic vesicle pathway; Insulin signaling; 7q11.23 copy number variation syndrome; Galanin receptor pathway; Sudden infant death syndrome (SIDS) susceptibility pathways",1207,1213.5,1248.2,1288,1639.9,2775.2,0.6432817239746803,-0.6364773934648034,0.20541034924903287,0.6873776790030152,0.45303085173843727,0.3438722212023602,3314]
["P63208","s-phase kinase-associated protein 1 [OS=Homo sapiens]",63,10,50,10,163,18.6,4.54,140.14,"protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","SKP1","ENSG00000113558","Cell cycle; Oocyte meiosis; Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum; Wnt signaling pathway; TGF-beta signaling pathway; Circadian rhythm; Shigellosis; Salmonella infection; Human immunodeficiency virus 1 infection; Pathways in cancer","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Regulation of RUNX2 expression and activity; Circadian Clock; Antigen processing: Ubiquitination & Proteasome degradation; Nuclear events stimulated by ALK signaling in cancer; SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Neddylation; SCF(Skp2)-mediated degradation of p27/p21; Negative regulation of NOTCH4 signaling; Regulation of PLK1 Activity at G2/M Transition; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Cyclin D associated events in G1; Regulation of BACH1 activity; MAP3K8 (TPL2)-dependent MAPK1/3 activation; NOTCH1 Intracellular Domain Regulates Transcription; Prolactin receptor signaling; Iron uptake and transport; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling","Cell cycle; TNF-alpha signaling pathway; TGF-beta signaling pathway; Breast cancer pathway; Small cell lung cancer; Notch signaling pathway (Netpath)",4487,4888.4,4194.9,5491.8,6301.1,4832,0.81626355647252,-0.2928930478077516,0.09619132498817085,1.0168640930313046,0.33147684787295645,0.47954679966389363,2121]
["P63279","SUMO-conjugating enzyme ubc9 [OS=Homo sapiens]",25,2,5,2,158,18,8.66,15.5,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","UBE2I","ENSG00000103275","Nucleocytoplasmic transport; NF-kappa B signaling pathway; Ubiquitin mediated proteolysis; MicroRNAs in cancer","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; Formation of Incision Complex in GG-NER; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; SUMOylation of intracellular receptors; Vitamin D (calciferol) metabolism; SUMOylation of transcription factors; Postmitotic nuclear pore complex (NPC) reformation; Negative regulation of activity of TFAP2 (AP-2) family transcription factors; Maturation of nucleoprotein; SUMOylation of immune response proteins; Maturation of nucleoprotein; SUMO is transferred from E1 to E2 (UBE2I, UBC9)","Androgen receptor signaling pathway; TGF-beta signaling pathway",692.7,701.8,640.6,740,735.9,271.4,1.1647112688147427,0.2199723560158429,0.5734553405416793,0.24150039835822876,0.7004319993347484,0.1546340213306607,5984]
["P67936","Tropomyosin alpha-4 chain [OS=Homo sapiens]",59,19,105,8,248,28.5,4.69,249.85,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","cytoskeletal activity;other molecular function","TPM4","ENSG00000167460","Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Hypertrophic cardiomyopathy; Dilated cardiomyopathy","Smooth Muscle Contraction; Striated Muscle Contraction; RHOV GTPase cycle; Signaling by ALK fusions and activated point mutants","Striated muscle contraction pathway",6011.7,6682.5,5291.9,5573.3,7100.9,6903,0.9187268863780315,-0.12229204537317584,0.44425158544339494,0.35237101361137413,0.606582260042177,0.2171102951108328,5353]
["P68133","Actin, alpha skeletal muscle [OS=Homo sapiens]",40,18,1223,3,377,42,5.39,3506.87,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ACTA1","ENSG00000143632","","Striated Muscle Contraction","Myometrial relaxation and contraction pathways; Fas ligand pathway and stress induction of heat shock proteins; Physico-chemical features and toxicity-associated pathways; Striated muscle contraction pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; IL-18 signaling pathway; Malignant pleural mesothelioma",39849,41125.6,40587.3,36132.3,36751.4,30290.6,1.1782188006121679,0.2366074791058221,0.04277261679118824,1.368834179174826,0.22523419029307987,0.647365683409689,1388]
["P69905","Hemoglobin subunit alpha [OS=Homo sapiens]",22,3,75,3,142,15.2,8.68,198.38,"other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;cytosol;translational apparatus;other cell component","other molecular function","HBA1; HBA2","ENSG00000188536; ENSG00000206172","African trypanosomiasis; Malaria","Heme signaling; Scavenging of heme from plasma; Cytoprotection by HMOX1; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Effects of nitric oxide",9029.9,8985.9,9034.5,7865.2,8607.6,9512.5,1.0409847105863699,0.05794887927785924,0.4977035566059284,0.30302925576228573,0.643274145929749,0.19160390313978692,5655]
["P78345","Ribonuclease P protein subunit p38 [OS=Homo sapiens]",18,4,6,4,283,31.8,9.92,14.17,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RPP38","ENSG00000152464","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus","Integrated breast cancer pathway; Sphingolipid metabolism in senescence",333,343.5,325.9,354.4,394.1,646.7,0.7184633027522935,-0.477013625455066,0.22643423107105712,0.6450579182898359,0.4699056771432017,0.3279893080371212,3522]
["P78356","Phosphatidylinositol 5-phosphate 4-kinase type-2 beta [OS=Homo sapiens]",31,11,34,6,416,47.3,7.33,83,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle","kinase activity;other molecular function","PIP4K2B","ENSG00000276293; ENSG00000277292","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Regulation of actin cytoskeleton","Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs in the nucleus","Regulation of actin cytoskeleton",1426.4,1339.4,1393.7,1416.7,1369,1797.6,0.9075338729736218,-0.13997660333923123,0.36376596147668966,0.43917794143101246,0.5593867899080843,0.252287793841798,4753]
["P78410-1","Butyrophilin subfamily 3 member A2 [OS=Homo sapiens]",25,6,11,4,334,36.4,5.33,34.54,"signal transduction;other biological processes","plasma membrane;other membranes","signal transduction activity or receptor binding","BTN3A2","ENSG00000186470","","Butyrophilin (BTN) family interactions","",1035.3,1018.5,1076.2,1023.1,1030.7,2349.8,0.7107820873830502,-0.49252077082137824,0.39052876924810725,0.4083469672528069,0.5736283710680097,0.24136937705159617,4976]
["P80297","metallothionein-1X [OS=Homo sapiens]",20,1,1,1,61,6.1,7.96,2.54,"stress response;other biological processes","nucleus;other cell component","other molecular function","MT1X","ENSG00000187193","Mineral absorption","Metallothioneins bind metals","Copper homeostasis; Zinc homeostasis; Oxidative stress response",58.1,53.6,60.1,37.4,43.8,45.9,1.3516915814319435,0.4347660061335048,0.009598310612701099,2.017805199892308,0.11315169720682634,0.9463389275065892,620]
["P80303","Nucleobindin-2 [OS=Homo sapiens]",8,3,4,3,420,50.2,5.12,11.01,"","","","","","","","",492.4,496.1,375.4,549.9,675.7,1040.7,0.601817941137537,-0.7326009785711584,0.11970026708822379,0.9219048805475378,0.363477047007822,0.4395230089385949,2407]
["P82673-1","28S ribosomal protein S35, mitochondrial [OS=Homo sapiens]",30,9,16,8,323,36.8,8.24,39.55,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPS35","ENSG00000061794","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1847.3,1872.4,1785.1,2088.7,2153.6,1718,0.9235776722648189,-0.11469479888900362,0.33342845221842354,0.47699734357749785,0.5443441048167205,0.26412647607697004,4477]
["P82912-1","28S ribosomal protein S11, mitochondrial [OS=Homo sapiens]",34,4,10,4,194,20.6,10.81,31.36,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes","other membranes;cytosol;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPS11","ENSG00000181991","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1014.1,943.3,959.6,924.6,883.1,973.7,1.0487524268354067,0.06867414909594995,0.25236337978245144,0.5979736649281252,0.49332012378441764,0.30687116819837185,3739]
["P82987-1","ADAMTS-like protein 3 [OS=Homo sapiens]",1,1,1,1,1691,188.6,7.83,0,"cell organization and biogenesis;protein metabolism","non-structural extracellular;extracellular matrix;other cell component","other molecular function","ADAMTSL3","ENSG00000156218","","Defective B3GALTL causes PpS; O-glycosylation of TSR domain-containing proteins","",25.6,28.1,33.9,24.2,24.2,2.5,1.7210216110019647,0.7832652135254782,0.18456795976129922,0.7338436885028551,0.4325127341761257,0.36400110137602587,3119]
["P84077","ADP-ribosylation factor 1 [OS=Homo sapiens]",73,11,196,5,181,20.7,6.8,662.51,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","ARF1","ENSG00000143761","Phospholipase D signaling pathway; Endocytosis; Vibrio cholerae infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Legionellosis","COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; COPI-mediated anterograde transport; Synthesis of PIPs at the plasma membrane; Intra-Golgi traffic; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis; trans-Golgi Network Vesicle Budding; Synthesis of PIPs at the Golgi membrane; Nef Mediated CD4 Down-regulation","Cell migration and invasion through p75NTR; Neural crest cell migration during development; Neural crest cell migration in cancer; Insulin signaling",15408.5,16168,16002.7,14093.5,15437.3,15953.2,1.0460645501714887,0.0649718796335512,0.3093686064819353,0.5095237589088031,0.5329189594099611,0.273338828791446,4243]
["P84095","Rho-related GTP-binding protein RhoG [OS=Homo sapiens]",60,8,48,7,191,21.3,8.12,179.23,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","RHOG","ENSG00000177105","Bacterial invasion of epithelial cells; Salmonella infection; Yersinia infection","Neutrophil degranulation; RHOG GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; RHO GTPases activate KTN1","Brain-derived neurotrophic factor (BDNF) signaling pathway",3286.6,3457.1,3477.4,2939.9,2946.6,2889.9,1.1646119137687434,0.21984928246957913,1.5821387456591892E-3,2.8007554337131837,0.044995533431996165,1.3468305951605053,257]
["P98155-1","very low-density lipoprotein receptor [OS=Homo sapiens]",1,1,1,1,873,96,4.79,1.97,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","VLDLR","ENSG00000147852","Spinocerebellar ataxia; Lipid and atherosclerosis","VLDLR internalisation and degradation; Reelin signalling pathway; VLDL clearance","Familial hyperlipidemia type 3",20.2,20.6,17.3,30.1,24,29.4,0.6958083832335329,-0.5232380339568858,0.018050544496062443,1.743509693034295,0.15521344673143578,0.8090706568646148,850]
["P99999","cytochrome c [OS=Homo sapiens]",41,4,26,4,105,11.7,9.57,56.92,"other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus","other molecular function","CYCS","ENSG00000172115","Oxidative phosphorylation; Metabolic pathways; Platinum drug resistance; p53 signaling pathway; Apoptosis; Apoptosis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Legionellosis; Toxoplasmosis; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Colorectal cancer; Small cell lung cancer; Viral myocarditis; Lipid and atherosclerosis","Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Respiratory electron transport; TP53 Regulates Metabolic Genes; Detoxification of Reactive Oxygen Species; Formation of apoptosome; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity; Release of apoptotic factors from the mitochondria; Pyroptosis","miRNA regulation of DNA damage response; Alzheimer's disease and miRNA effects; AGE/RAGE pathway; Parkinson's disease pathway; Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; VEGFA-VEGFR2 signaling pathway; Oxidative damage response; NO/cGMP/PKG mediated neuroprotection; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Acute viral myocarditis; Nonalcoholic fatty liver disease; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Malignant pleural mesothelioma; Complement system in neuronal development and plasticity; Alzheimer's disease; DNA damage response",2898.3,2670.5,2711.7,2887.8,2643.8,1661.9,1.1511086397442134,0.20302399908598845,0.3956181607378698,0.40272378045399454,0.5753229480368266,0.24008830282657875,5026]
["Q00013-1","55 kDa erythrocyte membrane protein [OS=Homo sapiens]",25,11,13,11,466,52.3,7.37,29.49,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","kinase activity","MPP1","ENSG00000130830; ENSGGOG00000001049; ENSPPAG00000040588; ENSPTRG00000022450; ENSPTRG00000051407","","Sensory processing of sound by outer hair cells of the cochlea","MECP2 and associated Rett syndrome",1312.4,1259.9,1283.2,1307,1263,1872.7,0.8678281225380964,-0.2045187564984864,0.37644783685486066,0.4242951940597669,0.5650969890269412,0.24787700672168825,4869]
["Q00577","Transcriptional activator protein Pur-alpha [OS=Homo sapiens]",43,9,24,9,322,34.9,6.44,87.56,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","PURA","ENSG00000185129","","","Exercise-induced circadian regulation",3141.2,3286.8,3318.5,3082,3126.9,1980.6,1.1901214970388914,0.25110886280047817,0.24251239363184554,0.6152660618106555,0.4837672175368884,0.3153635649224953,3664]
["Q00653-1","Nuclear factor NF-kappa-B p100 subunit [OS=Homo sapiens]",34,22,60,21,900,96.7,6.25,196.7,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NFKB2","ENSG00000077150","MAPK signaling pathway; NF-kappa B signaling pathway; Osteoclast differentiation; C-type lectin receptor signaling pathway; Legionellosis; Human T-cell leukemia virus 1 infection; Epstein-Barr virus infection; Pathways in cancer; Viral carcinogenesis; Breast cancer","Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; PKMTs methylate histone lysines; RIP-mediated NFkB activation via ZBP1; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; Interleukin-1 processing; DEx/H-box helicases activate type I IFN and inflammatory cytokines production ; SUMOylation of immune response proteins","Regulation of toll-like receptor signaling pathway; Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Neural crest differentiation; Thymic stromal lymphopoietin (TSLP) signaling pathway; TNF-alpha signaling pathway; Ebstein-Barr virus LMP1 signaling; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Toll-like receptor signaling related to MyD88; ApoE and miR-146 in inflammation and atherosclerosis; Ebola virus pathway in host; Breast cancer pathway; Acute viral myocarditis; miRNAs involvement in the immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Interactions between immune cells and microRNAs in tumor microenvironment; Head and neck squamous cell carcinoma; IL-18 signaling pathway; FGF23 signaling in hypophosphatemic rickets and related disorders; Mitochondrial immune response to SARS-CoV-2; Neuroinflammation and glutamatergic signaling; Network map of SARS-CoV-2 signaling pathway; Inclusion body myositis; Sudden infant death syndrome (SIDS) susceptibility pathways",6953.4,6619.8,6776.8,8031,7792.6,7409.6,0.8759017268391783,-0.19115908140222157,0.009398068526177417,2.0269613926358785,0.11223935107488683,0.9498548528974666,612]
["Q00987-1","E3 ubiquitin-protein ligase Mdm2 [OS=Homo sapiens]",14,6,9,6,491,55.2,4.69,20.89,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","MDM2","ENSG00000135679","Endocrine resistance; Platinum drug resistance; FoxO signaling pathway; Cell cycle; p53 signaling pathway; Ubiquitin mediated proteolysis; Endocytosis; PI3K-Akt signaling pathway; Cellular senescence; C-type lectin receptor signaling pathway; Thyroid hormone signaling pathway; Shigellosis; Human cytomegalovirus infection; Human papillomavirus infection; Epstein-Barr virus infection; Pathways in cancer; Transcriptional misregulation in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Glioma; Prostate cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia","Ub-specific processing proteases; Oxidative Stress Induced Senescence; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of RUNX3 expression and activity; SUMOylation of ubiquitinylation proteins; SUMOylation of transcription factors; Regulation of TP53 Degradation; Regulation of TP53 Activity through Phosphorylation; Oncogene Induced Senescence; Regulation of TP53 Activity through Methylation; AKT phosphorylates targets in the cytosol; Stabilization of p53; Trafficking of AMPA receptors","Androgen receptor signaling pathway; miRNA regulation of DNA damage response; TP53 network; Cell cycle; Glioblastoma signaling pathways; Retinoblastoma gene in cancer; Apoptosis; Bladder cancer; Copper homeostasis; VEGFA-VEGFR2 signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of p53 pathway in prostate cancer; PI3K-Akt signaling pathway; Genotoxicity pathway; G1 to S cell cycle control; Male infertility; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; Malignant pleural mesothelioma; Senescence and autophagy in cancer; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)",685.7,635.8,663.5,530,545.9,1817.5,0.686044100366351,-0.5436267760186196,0.5171883287482588,0.28635128428936274,0.6591333033689667,0.18102674464267623,5735]
["Q01167","Forkhead box protein K2 [OS=Homo sapiens]",8,5,12,4,660,69,9.54,25.47,"other metabolic processes;stress response;other biological processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","FOXK2","ENSG00000141568","","UCH proteinases","",530,522.9,502.7,582.5,557,677.6,0.8560893731770406,-0.22416667733957688,0.0812698965347305,1.0900702931501374,0.3090539405683378,0.509965714598691,1922]
["Q01518-1","adenylyl cyclase-associated protein 1 [OS=Homo sapiens]",53,23,275,1,475,51.9,8.06,908.04,"cell organization and biogenesis;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","CAP1","ENSG00000131236","","Neutrophil degranulation; Platelet degranulation ; Role of ABL in ROBO-SLIT signaling","Angiopoietin-like protein 8 regulatory pathway; Insulin signaling; Complement system in neuronal development and plasticity",575.8,591.7,563.1,597.1,577.2,848.1,0.8557159810126582,-0.22479606085106824,0.3289240527786276,0.4829043672984693,0.540734570795994,0.2670158637774681,4446]
["Q01581","hydroxymethylglutaryl-CoA synthase, cytoplasmic [OS=Homo sapiens]",20,9,22,9,520,57.3,5.41,67.63,"other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","other molecular function","HMGCS1","ENSG00000112972","Valine, leucine and isoleucine degradation; Butanoate metabolism; Terpenoid backbone biosynthesis; Metabolic pathways; PPAR signaling pathway","PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Endochondral ossification; Endochondral ossification with skeletal dysplasias",2574.2,2601.3,2548.6,5696.1,5759.4,3125.9,0.5297227975365878,-0.9166904960401838,0.05790917588683468,1.237252615525042,0.26159342803267904,0.5823731709173225,1618]
["Q01974","Tyrosine-protein kinase transmembrane receptor ROR2 [OS=Homo sapiens]",3,3,3,3,943,104.7,6.55,6.43,"cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","ROR2","ENSG00000169071","Wnt signaling pathway","WNT5A-dependent internalization of FZD2, FZD5 and ROR2","Cardiac progenitor differentiation; Ectoderm differentiation; Wnt signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Malignant pleural mesothelioma",356.5,387,391.1,382,433.9,580.4,0.8125760939626154,-0.2994251738685867,0.22215307936215054,0.6533476624333695,0.4661834214923797,0.33144317500763276,3483]
["Q02040-1","A-kinase anchor protein 17A [OS=Homo sapiens]",16,12,23,12,695,80.7,9.73,49.25,"RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus","other molecular function","AKAP17A","ENSG00000197976","","","",2564.6,2517.8,2579.1,2736.8,2832,2643.9,0.9328844350822506,-0.10022972255650384,0.03281044400729309,1.483987892484645,0.202886239635622,0.6927474071459085,1182]
["Q02241-1","Kinesin-like protein KIF23 [OS=Homo sapiens]",27,19,31,19,960,110,8.51,90.01,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KIF23","ENSG00000137807","MicroRNAs in cancer","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; MHC class II antigen presentation; Mitotic Telophase/Cytokinesis","Malignant pleural mesothelioma",2236.5,2251.6,2259.6,1867.2,1940.4,1736.3,1.2171395587943505,0.28349459881341926,0.002612761084902288,2.582900301046652,0.05839960479984961,1.2335900918229652,327]
["Q02383","Semenogelin-2 [OS=Homo sapiens]",1,1,2,1,582,65.4,9.07,4.54,"stress response;other biological processes","non-structural extracellular","other molecular function","SEMG2","ENSG00000124157","","","Genotoxicity pathway",333.4,347.5,311,377.9,362.2,513.4,0.7913043478260869,-0.337695410745679,0.1507711056978607,0.8216818802058534,0.40321478651506176,0.39446355001454114,2733]
["Q02556","Interferon regulatory factor 8 [OS=Homo sapiens]",2,1,2,1,426,48.3,6.77,2.2,"other metabolic processes;stress response;transport;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","IRF8","ENSG00000140968","Pertussis","Interferon gamma signaling; Interferon alpha/beta signaling","Vitamin D receptor pathway; Development of pulmonary dendritic cells and macrophage subsets; Type II interferon signaling (IFNG)",63,54.7,68.6,80.7,51.5,4163.5,0.04336895034569454,-4.527193663552879,0.37265550059581176,0.42869246396605964,0.5634545001768284,0.24914114815371818,4834]
["Q03001-7","dystonin [OS=Homo sapiens]",12,83,135,79,7570,860.1,5.25,375.37,"cell adhesion;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","DST","ENSG00000151914","","RND1 GTPase cycle; RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; Type I hemidesmosome assembly","",11318.4,11081.2,11177.2,13901.4,13249.9,12874.6,0.8388768272543529,-0.253469100377956,0.002210189642474841,2.6555704606375903,0.05366869135165652,1.2702789943474606,301]
["Q03252","Lamin-B2 [OS=Homo sapiens]",64,48,309,41,620,69.9,5.59,891.24,"","other membranes;cytoskeleton;nucleus","other molecular function","LMNB2","ENSG00000176619","Apoptosis","","Gastric cancer network 2; Fas ligand pathway and stress induction of heat shock proteins; IL-18 signaling pathway; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome",36664.4,36329.4,36261.1,37355.7,34099.4,36810.3,1.0091395773719025,0.013125732081257202,0.7614081729418758,0.11838246578733642,0.8364846439248715,0.07754202734941269,6653]
["Q03468","DNA excision repair protein ERCC-6 [OS=Homo sapiens]",3,4,4,4,1493,168.3,8.09,11.65,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","ERCC6","ENSG00000225830","Nucleotide excision repair","Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; B-WICH complex positively regulates rRNA expression; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression","Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum",372.8,334.4,356.7,445.7,415.7,379,0.857707191228636,-0.2214428782354384,0.05746811464507801,1.24057305052021,0.26056727663826007,0.5840801261053087,1612]
["Q04656-1","copper-transporting ATPase 1 [OS=Homo sapiens]",8,8,15,8,1500,163.3,6.24,40.93,"","","","","","","","",1102.5,1096.2,1086.2,1178.6,1128.2,1399.4,0.8863256165344555,-0.17409128430324064,0.16755889044473424,0.7758325241482777,0.4199890021469693,0.37676208191024185,2916]
["Q04695","Keratin, type I cytoskeletal 17 [OS=Homo sapiens]",27,12,31,3,432,48.1,5.02,86.77,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","other molecular function","KRT17","ENSG00000128422","Estrogen signaling pathway; Staphylococcus aureus infection","Formation of the cornified envelope","",328.4,355.8,261.1,287.3,360.6,1769.8,0.3909914381436903,-1.3547910788710527,0.36723153771691075,0.43506002880990935,0.561056711783633,0.25099323790629086,4784]
["Q05469-1","hormone-sensitive lipase [OS=Homo sapiens]",9,7,14,7,1076,116.5,6.7,42.9,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","LIPE","ENSG00000079435","cAMP signaling pathway; AMPK signaling pathway; Apelin signaling pathway; Thermogenesis; Insulin signaling pathway; Regulation of lipolysis in adipocytes; Aldosterone synthesis and secretion","Triglyceride catabolism","AMP-activated protein kinase (AMPK) signaling; Fatty acid beta-oxidation; Adipogenesis; Triacylglyceride synthesis; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Lipid metabolism pathway; Thermogenesis; Insulin signaling; Orexin receptor pathway; Familial partial lipodystrophy (FPLD)",662.3,657.5,709,682.7,678.1,921.7,0.8888499452354873,-0.1699882096195396,0.36121608622857143,0.44223291726013286,0.5575772701678202,0.2536949387154521,4735]
["Q05519","serine/arginine-rich splicing factor 11 [OS=Homo sapiens]",18,10,38,10,484,53.5,10.52,76.07,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","SRSF11","ENSG00000116754","","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript","",4542.4,4353.2,4376.4,4569.3,4557.2,3760.7,1.0298590849835494,0.042446947793622195,0.664167319251258,0.17772249793068773,0.7655573153142162,0.11602228923367629,6341]
["Q06124-2","Isoform 2 of Tyrosine-protein phosphatase non-receptor type 11 [OS=Homo sapiens]",39,21,47,21,593,68,7.3,127.47,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","PTPN11","ENSG00000179295; ENSMMUG00000013253; ENSRROG00000031729","Ras signaling pathway; Phospholipase D signaling pathway; Axon guidance; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; Leukocyte transendothelial migration; Neurotrophin signaling pathway; Adipocytokine signaling pathway; Insulin resistance; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Herpes simplex virus 1 infection; Proteoglycans in cancer; Chemical carcinogenesis; Renal cell carcinoma; Chronic myeloid leukemia; PD-L1 expression and PD-1 checkpoint pathway in cancer","PIP3 activates AKT signaling; GPVI-mediated activation cascade; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by SCF-KIT; RET signaling; Platelet sensitization by LDL; CTLA4 inhibitory signaling; FLT3 Signaling; Interleukin-3, Interleukin-5 and GM-CSF signaling; PD-1 signaling; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; Signal regulatory protein family interactions; PI3K Cascade; Downstream signal transduction; Tie2 Signaling; Interleukin-6 signaling; Signaling by Leptin; Regulation of IFNG signaling; Regulation of IFNA signaling; Signaling by CSF3 (G-CSF); GAB1 signalosome; PI-3K cascade:FGFR1; FRS-mediated FGFR1 signaling; PI-3K cascade:FGFR2; FRS-mediated FGFR2 signaling; FRS-mediated FGFR3 signaling; PI-3K cascade:FGFR3; FRS-mediated FGFR4 signaling; PI-3K cascade:FGFR4; Activated NTRK2 signals through FRS2 and FRS3; Spry regulation of FGF signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; Prolactin receptor signaling; Interleukin-20 family signaling; Netrin mediated repulsion signals; Interleukin-37 signaling; Signaling by FLT3 ITD and TKD mutants; PECAM1 interactions; MET activates PTPN11; STAT5 activation downstream of FLT3 ITD mutants; Regulation of RUNX1 Expression and Activity; STAT5 Activation","IL-5 signaling pathway; Heart development; IL-1 signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Pilocytic astrocytoma; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL-6 signaling pathway; Hepatitis C and hepatocellular carcinoma; VEGFA-VEGFR2 signaling pathway; Embryonic stem cell pluripotency pathways; IL-4 signaling pathway; Ras signaling; EGF/EGFR signaling pathway; Fragile X syndrome; Cancer immunotherapy by CTLA4 blockade; Cancer immunotherapy by PD-1 blockade; Gastrin signaling pathway; Netrin-UNC5B signaling pathway; Insulin signaling; IL-2 signaling pathway; Angiotensin II receptor type 1 pathway; Kallmann syndrome; Interferon type I signaling pathways; Type II interferon signaling (IFNG); T-cell receptor (TCR) signaling pathway",5862.3,5881.2,5852.5,5829.4,5349.3,5228,{"$f":"AVERAGE(S2626:U2626)/AVERAGE(V2626:X2626)","v":1.072488678405773},{"$f":"LOG(Y2626,2)","v":0.10096241817325187},{"$f":"TTEST(S2626:U2626,V2626:X2626,2,2)","v":0.09724558482855454},{"$f":"-LOG10(AA2626)","v":1.0121301075150964},{"$f":"AA2626*7309/AE2626","v":0.33244526637600796},{"$f":"-LOG10(AC2626)","v":0.4782798465038826},2138]
["Q06481","Amyloid-like protein 2 [OS=Homo sapiens]",4,4,4,4,763,86.9,4.79,8.09,"signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","APLP2","ENSG00000084234","","Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","Splicing factor NOVA regulated synaptic proteins",600.1,617,606.2,455,450.7,610.3,1.2027044854881266,0.26628220386576257,0.12400644247875854,0.9065557514483039,0.36874006837967704,0.43327966811476626,2458]
["Q07020","60S ribosomal protein L18 [OS=Homo sapiens]",46,8,48,8,188,21.6,11.72,150.29,"protein metabolism;other metabolic processes","cytosol;ER/Golgi;translational apparatus;nucleus","nucleic acid binding activity;other molecular function","RPL18","ENSG00000063177","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis","Cytoplasmic ribosomal proteins",6226.3,6558.6,6891.1,6706,7625.6,6459.6,0.9463619223517642,-0.07953606806028407,0.4089165561858481,0.3883653054041041,0.5823794055265713,0.234793991223022,5132]
["Q07157","Tight junction protein ZO-1 [OS=Homo sapiens]",18,28,46,26,1748,195.3,6.7,137.15,"cell adhesion;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","TJP1","ENSG00000104067; ENSG00000277401","Adherens junction; Tight junction; Gap junction; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection","RUNX1 regulates expression of components of tight junctions; Signaling by Hippo; Apoptotic cleavage of cell adhesion  proteins; Regulation of gap junction activity","Epithelial to mesenchymal transition in colorectal cancer; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; Disruption of postsynaptic signaling by CNV; 1q21.1 copy number variation syndrome",4241.5,4026.2,4209.9,5215.9,4976.2,7524.5,0.7042886332592032,-0.5057612960915469,0.09884266403954822,1.0050555578664413,0.33399955222610167,0.4762541154215599,2163]
["Q07866-6","Isoform N of Kinesin light chain 1 [OS=Homo sapiens]",38,25,77,21,628,71,6.67,227.5,"","","","KLC1","","","","",9569.9,9648.4,9500.9,9975.5,10145.3,6531.6,1.0775464873707432,0.10775011121925916,0.5900770367464665,0.22909128590047395,0.7099379525234443,0.14877960628685077,6075]
["Q07889","Son of sevenless homolog 1 [OS=Homo sapiens]",7,8,10,8,1333,152.4,6.84,23.92,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","SOS1","ENSG00000115904","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Chemokine signaling pathway; FoxO signaling pathway; Phospholipase D signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Focal adhesion; Gap junction; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Thermogenesis; Neurotrophin signaling pathway; Regulation of actin cytoskeleton; Insulin signaling pathway; GnRH signaling pathway; Estrogen signaling pathway; Prolactin signaling pathway; Relaxin signaling pathway; Growth hormone synthesis, secretion and action; Alcoholism; Hepatitis C; Hepatitis B; Human cytomegalovirus infection; Human papillomavirus infection; Pathways in cancer; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Endometrial cancer; Glioma; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Choline metabolism in cancer","RAC1 GTPase cycle; Role of LAT2/NTAL/LAB on calcium mobilization; RET signaling; FLT3 Signaling; Downstream signal transduction; Tie2 Signaling; FRS-mediated FGFR1 signaling; FRS-mediated FGFR2 signaling; FRS-mediated FGFR3 signaling; FRS-mediated FGFR4 signaling; Activated NTRK2 signals through FRS2 and FRS3; Signaling by FLT3 ITD and TKD mutants; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; NRAGE signals death through JNK; G alpha (12/13) signalling events; Interleukin receptor SHC signaling; RAF/MAP kinase cascade; DAP12 signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; Regulation of KIT signaling; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; GRB2 events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; GRB2 events in EGFR signaling; SHC1 events in EGFR signaling; NCAM signaling for neurite out-growth; Signaling by FGFR1 in disease; SHC-mediated cascade:FGFR1; SHC-mediated cascade:FGFR2; Signaling by FGFR2 in disease; SHC-mediated cascade:FGFR3; SHC-mediated cascade:FGFR4; Signaling by FGFR3 point mutants in cancer; Activation of RAC1; Erythropoietin activates RAS; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; SOS-mediated signalling; Signalling to RAS; SHC-related events triggered by IGF1R; Signaling by FGFR4 in disease; MET activates RAS signaling; Signaling by FGFR3 fusions in cancer; Activated NTRK2 signals through RAS; Activated NTRK3 signals through RAS; Constitutive Signaling by Overexpressed ERBB2; Signaling by FLT3 fusion proteins; Signal attenuation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Interleukin-15 signaling","IL-5 signaling pathway; Integrin-mediated cell adhesion; Leptin signaling pathway; Prolactin signaling pathway; Pilocytic astrocytoma; B cell receptor signaling pathway; TNF-alpha signaling pathway; Oncostatin M signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL-6 signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Acute viral myocarditis; Thermogenesis; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Malignant pleural mesothelioma; Regulation of actin cytoskeleton; EPO receptor signaling; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent)",881.4,790.4,818,809.9,795.5,843.6,1.0166598611678237,0.02383708461768605,0.6785141330392617,0.16844110181848285,0.775854161198993,0.11021990624044489,6392]
["Q08378","Golgin subfamily A member 3 [OS=Homo sapiens]",27,31,49,31,1498,167.3,5.44,179.93,"other biological processes","other membranes;cytosol;ER/Golgi;nucleus","","GOLGA3","ENSG00000090615","","RND2 GTPase cycle","",3741.6,3832.4,3878.2,4138.6,4304.2,5305.8,0.8329720844304149,-0.2636599478303283,0.1052128349070178,0.9779312773943909,0.3428446769217089,0.4649025890933857,2243]
["Q08752","peptidyl-prolyl cis-trans isomerase D [OS=Homo sapiens]",59,23,87,22,370,40.7,7.21,264.19,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","PPID","ENSG00000171497","Necroptosis; Cellular senescence; Alzheimer disease; Pathways of neurodegeneration; Shigellosis","ESR-mediated signaling","Alzheimer's disease and miRNA effects; NO/cGMP/PKG mediated neuroprotection; Alzheimer's disease",11950.2,11772,11776.2,12414,12837.2,11379.6,0.9690861242451707,-0.0453032089167167,0.43632844342072175,0.36018647525973335,0.6005884355860744,0.22142303445722944,5310]
["Q08AD1","Calmodulin-regulated spectrin-associated protein 2 [OS=Homo sapiens]",8,9,11,9,1489,168,6.8,30.42,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi","cytoskeletal activity;other molecular function","CAMSAP2","ENSG00000118200","","","",929.2,941.4,935,1041.6,1035.4,2342.4,0.6348373082318867,-0.6555411796639914,0.283539425045222,0.5473865456276724,0.5161618076352497,0.2872141333583993,4015]
["Q09327","Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase [OS=Homo sapiens]",8,3,3,3,533,61.3,8.28,8.11,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi","other molecular function","MGAT3","ENSG00000128268","N-Glycan biosynthesis; Metabolic pathways","Reactions specific to the hybrid N-glycan synthesis pathway","",134.9,135.1,139.7,235.5,286.9,183.4,0.580476055539813,-0.7846915372994231,0.029964736895628907,1.5233895312589423,0.19695347299474072,0.7056363566210079,1112]
["Q0P6H9","Transmembrane protein 62 [OS=Homo sapiens]",11,5,7,5,643,73.1,9.26,26.35,"","other membranes","other molecular function","TMEM62","ENSG00000137842","","","",417.6,424.5,423.3,481.6,412.6,618.7,{"$f":"AVERAGE(S2690:U2690)/AVERAGE(V2690:X2690)","v":0.8364069006543724},{"$f":"LOG(Y2690,2)","v":-0.25772313016363213},{"$f":"TTEST(S2690:U2690,V2690:X2690,2,2)","v":0.24507321950742156},{"$f":"-LOG10(AA2690)","v":0.610704143891117},{"$f":"AA2690*7309/AE2690","v":0.4855625268039426},{"$f":"-LOG10(AC2690)","v":0.31375483723394754},3689]
["Q0VDG4-1","secernin-3 [OS=Homo sapiens]",26,9,16,9,424,48.5,5.55,46.04,"protein metabolism","","other molecular function","SCRN3","ENSG00000144306","","","",1477.4,1443.1,1480,1498.9,1465.6,1103.5,1.0817354965585053,0.11334777785858872,0.4326561905323195,0.3638570779311687,0.5986906657706784,0.22279751291810101,5282]
["Q11201","CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 [OS=Homo sapiens]",15,4,7,4,340,39.1,9.09,28.5,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","ST3GAL1","ENSG00000008513","Mucin type O-glycan biosynthesis; Glycosaminoglycan biosynthesis; Glycosphingolipid biosynthesis; Glycosphingolipid biosynthesis; Metabolic pathways","Maturation of spike protein; Sialic acid metabolism; Keratan sulfate biosynthesis; Maturation of protein 3a; Maturation of protein 3a; Termination of O-glycan biosynthesis","Ganglio sphingolipid metabolism; Globo sphingolipid metabolism",579.3,559,542.2,760,842.4,894.8,0.6729537081531315,-0.5714208282611267,0.00259177219752858,2.586403173211947,0.058647873039431545,1.2317477336590767,323]
["Q12765","Secernin-1 [OS=Homo sapiens]",3,1,1,1,414,46.4,4.75,2.14,"protein metabolism;transport","other membranes;nucleus;other cell component","other molecular function","SCRN1","ENSG00000136193","","","",38,40.4,41.9,49.1,27.6,96.7,0.6937716262975778,-0.5274672560457586,0.43552983913893345,0.36098208513519503,0.600167344318715,0.22172763864793885,5304]
["Q12792-2","Twinfilin-1 [OS=Homo sapiens]",40,12,33,9,350,40.3,6.96,94.03,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","TWF1","ENSG00000151239","","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHOBTB2 GTPase cycle","",2156.2,2146.9,2135.3,2219.2,2014.8,2623.6,0.9388707419505368,-0.09100154487102026,0.4785891024285799,0.32003719458387775,0.6320939193441436,0.1992183875048379,5534]
["Q12824-1","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 [OS=Homo sapiens]",37,10,52,10,385,44.1,6.23,155.01,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","LOC101347788; LOC111142756; Smarcb1; SMARCB1","ENSCAFG00000014105; ENSCATG00000029590; ENSCCAG00000036123; ENSCHIG00000019816; ENSCSAG00000011285; ENSDLEG00000015913; ENSECAG00000007797; ENSG00000099956; ENSG00000275837; ENSHGLG00000019077; ENSMFAG00000040790; ENSMLUG00000004975; ENSMMUG00000009098; ENSMNEG00000033936; ENSMUSG00000000902; ENSPANG00000026464; ENSPPAG00000028391; ENSRBIG00000027964; ENSRFEG00010017090; ENSRROG00000030710; ENSSBOG00000031674; ENSSSCG00000010070; ENSSSCG00070020965; ENSSSUG00005014167; ENSSTOG00000012408; ENSTSYG00000008262; ENSUAMG00000010813","Thermogenesis; Hepatocellular carcinoma","RMTs methylate histone arginines; RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines","TNF-alpha NF-kB signaling pathway; Tumor suppressor activity of SMARCB1; Thermogenesis; Modulators of TCR signaling and T cell activation",2836.6,2711,2744.6,2911.4,2810.9,2680.2,0.9868729544778341,-0.019063724230123664,0.6568810476711349,0.18251326821381125,0.7593141827341965,0.1195784881430566,6323]
["Q12851","Mitogen-activated protein kinase kinase kinase kinase 2 [OS=Homo sapiens]",13,8,11,8,820,91.5,6.34,30,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi","kinase activity;other molecular function","MAP4K2","ENSG00000168067","MAPK signaling pathway","","TNF-alpha signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Insulin signaling; Malignant pleural mesothelioma",604.5,579.3,606.3,629.5,640.7,731.2,0.8944239032677125,-0.1609693505065921,0.1023016889735559,0.990117196142773,0.34018336883881717,0.46828692234627184,2198]
["Q12893","Transmembrane protein 115 [OS=Homo sapiens]",15,4,8,4,351,38.2,8.16,28.67,"transport;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","TMEM115","ENSG00000126062","","COPI-mediated anterograde transport","",419.6,422.7,430,405.9,346.6,449.4,1.0585739246193524,0.08212202225785216,0.4771322744210271,0.32136120568192705,0.6310821197508664,0.1999141243784466,5526]
["Q12907","Vesicular integral-membrane protein VIP36 [OS=Homo sapiens]",42,13,93,13,356,40.2,6.95,303.48,"cell organization and biogenesis;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","LMAN2","ENSG00000169223","Protein processing in endoplasmic reticulum","COPII-mediated vesicle transport; Cargo concentration in the ER","",12738,13668,13606.5,12068.5,12275,12963.1,1.0725314019503251,0.10101988807428187,0.08941078321559864,1.0486101007944322,0.3233564643853589,0.4903184524257634,2021]
["Q12931","heat shock protein 75 kDa, mitochondrial [OS=Homo sapiens]",50,30,194,29,704,80.1,8.21,663.74,"other biological processes","other membranes;mitochondrion;nucleus","signal transduction activity or receptor binding;other molecular function","TRAP1","ENSG00000126602","Parkinson disease; Pathways of neurodegeneration","Respiratory electron transport","TNF-alpha signaling pathway; TGF-beta signaling pathway",16865.6,16688.1,16897.8,15818.5,15338.3,15506.9,1.0811723030964113,0.11259645925562563,1.2369083415141125E-3,2.907662481655845,0.038634884906524135,1.4130203771820151,234]
["Q12979","active breakpoint cluster region-related protein [OS=Homo sapiens]",17,15,38,15,859,97.5,6.55,106.76,"signal transduction;other biological processes","cytosol;other cell component","enzyme regulator activity","ABR","ENSG00000159842; ENSG00000276016; ENSG00000278741","","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC3 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOC GTPase cycle; RAC2 GTPase cycle; RHOB GTPase cycle","",4750.1,4727.9,4625.2,4838.1,4608.3,3004.6,1.1326961689824109,0.1797609288671775,0.39461719379905763,0.4038239961001077,0.5746676767239116,0.24058322989819167,5019]
["Q12982","BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 [OS=Homo sapiens]",13,5,6,5,314,36,4.81,16.43,"other metabolic processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","BNIP2","ENSG00000140299","","Myogenesis","Acute viral myocarditis",867,802.1,831.7,896.2,992.8,623.9,0.9951848461936409,-0.006963577352663375,0.9730048371495192,0.011885000695550903,0.9825493720262276,7.645617583758515E-3,7238]
["Q13033-2","Isoform Alpha of Striatin-3 [OS=Homo sapiens]",11,6,9,1,713,77.7,5.26,23.04,"","","","STRN3","","","","",31.7,35.6,30.6,29.7,41.2,39.5,0.8867753623188405,-0.17335940717447423,0.34461547230019773,0.46266522780571656,0.5516413681651654,0.25834317307596005,4566]
["Q13085-1","Acetyl-CoA carboxylase 1 [OS=Homo sapiens]",18,34,70,29,2346,265.4,6.37,209.21,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","ACACA","ENSG00000275176; ENSG00000278540","Fatty acid biosynthesis; Pyruvate metabolism; Propanoate metabolism; Metabolic pathways; Fatty acid metabolism; AMPK signaling pathway; Insulin signaling pathway; Glucagon signaling pathway; Alcoholic liver disease","Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency; ChREBP activates metabolic gene expression; Carnitine metabolism; Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis","AMP-activated protein kinase (AMPK) signaling; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; Corticotropin-releasing hormone signaling pathway; Mesodermal commitment pathway; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin and adiponectin; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Mitochondrial fatty acid synthesis pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; 7q11.23 copy number variation syndrome",6408.3,6450.9,6385.6,6580.9,6338.7,7368.5,0.9485757660894812,-0.07616508351095529,0.32671214789311437,0.48583471717787535,0.539891270393573,0.26769369466350607,4423]
["Q13107-1","Ubiquitin carboxyl-terminal hydrolase 4 [OS=Homo sapiens]",25,18,30,17,963,108.5,5.71,84.23,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","USP4","ENSG00000114316","","Ub-specific processing proteases; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; TNFR1-induced proapoptotic signaling","",2244.3,2226.4,2265,2510.5,2349.7,2009,0.9805654224654984,-0.028314205910186827,0.7790203977581924,0.10845117067422815,0.8495762589099713,0.07079763228950792,6702]
["Q13144","Translation initiation factor eIF-2B subunit epsilon [OS=Homo sapiens]",25,14,54,14,721,80.3,5.08,172.66,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;translational apparatus;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","EIF2B5","ENSG00000145191","Herpes simplex virus 1 infection","Recycling of eIF2:GDP","Translation factors; MicroRNAs in cardiomyocyte hypertrophy",4989.8,4877.1,4859.2,4725.6,4582.1,6262.7,0.9457753172686636,-0.08043060388331216,0.6294200323179763,0.20105943907340112,0.7386690777476057,0.13155008108551086,6228]
["Q13164-1","Mitogen-activated protein kinase 7 [OS=Homo sapiens]",8,4,10,4,816,88.3,5.88,27.2,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","MAPK7","ENSG00000166484","MAPK signaling pathway; Gap junction; IL-17 signaling pathway; Neurotrophin signaling pathway; GnRH signaling pathway; Oxytocin signaling pathway; MicroRNAs in cancer; Fluid shear stress and atherosclerosis","Senescence-Associated Secretory Phenotype (SASP); Gastrin-CREB signalling pathway via PKC and MAPK; ERKs are inactivated; RET signaling; Signalling to ERK5","MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Brain-derived neurotrophic factor (BDNF) signaling pathway; S1P receptor signal transduction; Cardiac hypertrophic response; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Osteoblast differentiation and related diseases; Insulin signaling; Malignant pleural mesothelioma",313.1,241.2,251.4,256.1,273.9,513.5,0.7721130809774797,-0.3731159398573628,0.40873459661549005,0.3885586006458946,0.5825743304724292,0.2346486552726826,5128]
["Q13188","serine/threonine-protein kinase 3 [OS=Homo sapiens]",22,10,38,6,491,56.3,5.24,113.73,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","STK3","ENSG00000104375","MAPK signaling pathway; Hippo signaling pathway; Hippo signaling pathway","Signaling by Hippo","MAPK signaling pathway; Transcription co-factors SKI and SKIL protein partners; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Overview of leukocyte-intrinsic Hippo pathway functions; Malignant pleural mesothelioma",1027.8,1116.5,1116.3,957.6,1044.5,679.1,1.2160972698791588,0.28225862776171445,0.16576833641673358,0.7804984209071761,0.41808170147339746,0.3787388401583589,2898]
["Q13232","Nucleoside diphosphate kinase 3 [OS=Homo sapiens]",37,6,24,6,169,19,7.84,62.61,"other metabolic processes;other biological processes","cytosol","kinase activity;other molecular function","NME3","ENSG00000103024","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors","Interconversion of nucleotide di- and triphosphates","Pyrimidine metabolism",3205.8,3318.9,3179.5,3073,3146.3,3209.7,1.0291865521264185,0.041504511322245266,0.19018467493391422,0.7208244814037688,0.4385046653287,0.3580257817375473,3170]
["Q13243-1","Serine/arginine-rich splicing factor 5 [OS=Homo sapiens]",30,9,51,8,272,31.2,11.59,160.37,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","SFRS5; SRSF5","ENSCANG00000030560; ENSCCAG00000029002; ENSCJAG00000014884; ENSCSAG00000013041; ENSG00000100650; ENSGGOG00000016462; ENSMFAG00000002393; ENSMMUG00000022407; ENSMNEG00000030872; ENSNLEG00000001615; ENSPPAG00000029921; ENSPPYG00000005945; ENSPTRG00000006488; ENSRBIG00000013003; ENSRROG00000043407; ENSSBOG00000030784","Spliceosome; Herpes simplex virus 1 infection","mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","mRNA processing; mRNA Processing",5807.5,5642.8,5736.3,5863.6,6091,6165.1,0.9485035624210112,-0.07627490271874542,0.038589314470510415,1.4135329364925828,0.21514057930202943,0.6672776662986942,1311]
["Q13303-2","Isoform 2 of Voltage-gated potassium channel subunit beta-2 [OS=Homo sapiens]",48,13,60,13,353,39.3,8.62,152.58,"","","","KCNAB2","","","","",6280.7,6305.5,6314.6,5938.5,5925.7,5065.1,1.11645490362862,0.15892497832088115,0.08550525050964808,1.0680072162969128,0.31611425188417697,0.500155923726612,1977]
["Q13325","Interferon-induced protein with tetratricopeptide repeats 5 [OS=Homo sapiens]",21,9,16,9,482,55.8,7.4,47.35,"stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity","IFIT5","ENSG00000152778","","Interferon alpha/beta signaling","",1353.1,1319.6,1322.8,1588.6,1413.3,981.1,1.003138337936229,0.00452057473615069,0.982721117114363,0.007569711549781782,0.9886729036460948,0.004947368299849188,7265]
["Q13395","Probable methyltransferase TARBP1 [OS=Homo sapiens]",2,3,3,3,1621,181.6,7.05,7.9,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","TARBP1","ENSG00000059588","","","",254,274,253.8,285.2,281.5,464.3,0.7582929194956352,-0.39917284296618033,0.24296836025077126,0.6144502772788321,0.4842802686318209,0.3149032253554618,3667]
["Q13423","NAD(P) transhydrogenase, mitochondrial [OS=Homo sapiens]",42,39,277,39,1086,113.8,8.09,854.59,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","NNT","ENSG00000112992","Nicotinate and nicotinamide metabolism; Metabolic pathways","Citric acid cycle (TCA cycle)","",38567.2,39705.7,40579.2,34477,35727.9,32138,1.1613126069321857,0.215756375101685,0.010213104041572411,1.9908422438828883,0.11645487900133035,0.9338423115177327,641]
["Q13433-1","Zinc transporter ZIP6 [OS=Homo sapiens]",3,2,3,2,755,85,6.95,8.51,"transport;other biological processes","plasma membrane;other membranes;ER/Golgi","transporter activity","SLC39A6","ENSG00000141424","Alzheimer disease; Parkinson disease","Zinc influx into cells by the SLC39 gene family","Nuclear receptors meta-pathway; NRF2 pathway; Zinc homeostasis",510.4,572.4,563.3,508.5,501.1,549.7,1.0556660039761427,0.07815346099862598,0.3037201693208319,0.5175263666794019,0.5282938404488245,0.27712445286536264,4202]
["Q13439-1","Golgin subfamily A member 4 [OS=Homo sapiens]",23,44,60,42,2230,261,5.39,181.85,"cell organization and biogenesis;transport;developmental processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","GOLGA4","ENSG00000144674","","Retrograde transport at the Trans-Golgi-Network; Signaling by membrane-tethered fusions of PDGFRA or PDGFRB","",4602.7,4543.8,4457.3,5062.7,4901,5392,0.885912071738833,-0.1747645789076907,0.017842520456398964,1.7485437966533597,0.15451538153533179,0.8110282813950419,844]
["Q13464","Rho-associated protein kinase 1 [OS=Homo sapiens]",36,47,75,41,1354,158.1,5.9,189.39,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function","ROCK1","ENSG00000067900","cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Vascular smooth muscle contraction; TGF-beta signaling pathway; Axon guidance; Focal adhesion; Tight junction; Platelet activation; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Pathogenic Escherichia coli infection; Shigellosis; Yersinia infection; Human cytomegalovirus infection; Pathways in cancer; Proteoglycans in cancer; MicroRNAs in cancer","Neutrophil degranulation; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHOB GTPase cycle; Sema4D induced cell migration and growth-cone collapse; RND3 GTPase cycle; RHOBTB1 GTPase cycle; EPHB-mediated forward signaling; Potential therapeutics for SARS; VEGFA-VEGFR2 Pathway; Apoptotic cleavage of cellular proteins; EPHA-mediated growth cone collapse; RHO GTPases Activate ROCKs; RHOH GTPase cycle","Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Microtubule cytoskeleton regulation; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Focal adhesion; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; EGF/EGFR signaling pathway; Gastrin signaling pathway; mBDNF and proBDNF regulation of GABA neurotransmission; MAP3K1 role in promoting and blocking gonadal determination; Airway smooth muscle cell contraction; RAS and bradykinin pathways in COVID-19; Regulation of actin cytoskeleton; G13 signaling pathway",8415.5,8207.8,8330.5,8906.5,8483,7989,0.9832653624130661,-0.024347273059112776,0.6300826951435519,0.20060244786760245,0.7389721467914346,0.13137193064813754,6232]
["Q13480-1","GRB2-associated-binding protein 1 [OS=Homo sapiens]",26,13,23,13,694,76.6,5.96,75.05,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;other cell component","","GAB1","ENSG00000109458","EGFR tyrosine kinase inhibitor resistance; ErbB signaling pathway; Ras signaling pathway; Phospholipase D signaling pathway; Neurotrophin signaling pathway; Bacterial invasion of epithelial cells; Proteoglycans in cancer; Renal cell carcinoma; Hepatocellular carcinoma; Gastric cancer","Signaling by ERBB2 KD Mutants; Signaling by FGFR1 in disease; Signaling by FGFR2 in disease; Signaling by FGFR3 point mutants in cancer; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FGFR4 in disease; Signaling by FGFR3 fusions in cancer; RET signaling; PIP3 activates AKT signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Constitutive Signaling by Aberrant PI3K in Cancer; MET activates RAP1 and RAC1; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); PI3K Cascade; PI3K events in ERBB2 signaling; GAB1 signalosome; PI-3K cascade:FGFR1; PI-3K cascade:FGFR2; PI-3K cascade:FGFR3; PI-3K cascade:FGFR4; MET activates PI3K/AKT signaling; MET activates PTPN11; MET receptor recycling; Activated NTRK2 signals through PI3K","Glioblastoma signaling pathways; B cell receptor signaling pathway; Alpha 6 beta 4 signaling pathway; Hepatocyte growth factor receptor signaling; IL-6 signaling pathway; BDNF-TrkB signaling; VEGFA-VEGFR2 signaling pathway; Embryonic stem cell pluripotency pathways; Ras signaling; EGF/EGFR signaling pathway; Fragile X syndrome; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; ErbB signaling pathway",2267.2,2204.4,2248.6,2221.9,2218,2830.7,0.9242978571232087,-0.11357025650527189,0.4202244513228609,0.37651868118840703,0.5890718286764078,0.22983174613674417,5214]
["Q13510","Acid ceramidase [OS=Homo sapiens]",39,14,67,14,395,44.6,7.62,179.54,"other metabolic processes;developmental processes;other biological processes","non-structural extracellular;nucleus;other cytoplasmic organelle;other cell component","other molecular function","ASAH1","ENSG00000104763","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway; Lysosome","Neutrophil degranulation; Glycosphingolipid metabolism","Sphingolipid pathway; S1P receptor signal transduction; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway; Sphingolipid metabolism in senescence",7384.3,7501.5,7513,6810.9,7121.3,6359.6,1.1038350466690976,0.14252459681459123,0.035439915239169534,1.450507325475872,0.20872710756091065,0.680421145090629,1241]
["Q13555-8","Isoform 8 of Calcium/calmodulin-dependent protein kinase type II subunit gamma [OS=Homo sapiens]",27,11,24,9,556,62.1,7.42,70.38,"protein metabolism;other metabolic processes;other biological processes","other cell component","kinase activity;other molecular function","CAMK2G; LOC111145432","ENSCATG00000041481; ENSECAG00000000031; ENSFCAG00000018407; ENSG00000148660; ENSLCNG00005022562; ENSMPUG00000003376; ENSPANG00000022457; ENSPTRG00000002643","ErbB signaling pathway; Calcium signaling pathway; cAMP signaling pathway; HIF-1 signaling pathway; Oocyte meiosis; Necroptosis; Adrenergic signaling in cardiomyocytes; Wnt signaling pathway; Axon guidance; Circadian entrainment; Long-term potentiation; Neurotrophin signaling pathway; Cholinergic synapse; Dopaminergic synapse; Olfactory transduction; Inflammatory mediator regulation of TRP channels; Insulin secretion; GnRH signaling pathway; Melanogenesis; Oxytocin signaling pathway; Glucagon signaling pathway; Aldosterone synthesis and secretion; Cushing syndrome; Gastric acid secretion; Parkinson disease; Pathways of neurodegeneration; Amphetamine addiction; Tuberculosis; Pathways in cancer; Proteoglycans in cancer; Glioma; Diabetic cardiomyopathy; Lipid and atherosclerosis","","Energy metabolism; Myometrial relaxation and contraction pathways; NO/cGMP/PKG mediated neuroprotection; Splicing factor NOVA regulated synaptic proteins; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Disruption of postsynaptic signaling by CNV; Neuroinflammation and glutamatergic signaling; Calcium regulation in cardiac cells; ErbB signaling pathway; Calcium regulation in cardiac cells",2218.4,2301.4,2227.8,1871.5,1771.1,1723.9,1.2573558185036804,0.33039297509596066,8.2298247218335837E-4,3.0846094142593086,0.033233032536951194,1.47843002724452,181]
["Q13564-1","NEDD8-activating enzyme E1 regulatory subunit [OS=Homo sapiens]",54,17,64,17,534,60.2,5.4,215.51,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","NAE1","ENSG00000159593","Alzheimer disease","Neddylation","Alzheimer's disease and miRNA effects; Hijack of ubiquitination by SARS-CoV-2; Alzheimer's disease",5860.6,5754.2,5839.8,5694.2,5645.9,6678.4,0.9687043871576434,-0.04587161938934772,0.6077493865919702,0.2162754708225237,0.7215789906758788,0.14171612009799187,6156]
["Q13576-1","Ras GTPase-activating-like protein IQGAP2 [OS=Homo sapiens]",47,62,224,61,1575,180.5,5.64,738.75,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","IQGAP2","ENSG00000145703","Regulation of actin cytoskeleton","CDC42 GTPase cycle; RAC1 GTPase cycle; Neutrophil degranulation; RHOG GTPase cycle; RHO GTPases activate IQGAPs","Ciliary landscape; G13 signaling pathway",23269.7,23360.1,23609.8,21279.9,21419.5,18646.7,1.1449725410417289,0.19531299973885838,0.030898300640531954,1.510065405453302,0.19914962908434572,0.7008204981262169,1134]
["Q13614-1","Myotubularin-related protein 2 [OS=Homo sapiens]",8,3,3,3,643,73.3,7.4,11.38,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MTMR2","ENSG00000087053; ENSGGOG00000010339; ENSPPAG00000042525; ENSPTRG00000004195","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; Synthesis of PIPs at the ER membrane","Intracellular trafficking proteins involved in CMT neuropathy",69.9,92.1,74.1,86.8,87,158,0.7115732368896925,-0.4909158447272207,0.2654292701151711,0.5760511871664573,0.5023362338870496,0.2990054947258602,3862]
["Q13617-1","Cullin-2 [OS=Homo sapiens]",37,25,81,25,745,86.9,6.92,223.45,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction","cytosol;nucleus;other cell component","other molecular function","CUL2","ENSCANG00000032700; ENSCATG00000031722; ENSCCAG00000022671; ENSG00000108094; ENSMFAG00000044478; ENSMMUG00000002469; ENSMNEG00000040111; ENSPANG00000022742; ENSPPYG00000019905","HIF-1 signaling pathway; Ubiquitin mediated proteolysis; Pathways in cancer; Renal cell carcinoma","Antigen processing: Ubiquitination & Proteasome degradation; Regulation of expression of SLITs and ROBOs; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Neddylation","Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2",9422.2,9322.2,9345.7,9142.9,8258.9,7409.4,1.1321540272135164,0.17907024719852216,0.09474461369855561,1.023445470620974,0.33007072522533026,0.48139299259454005,2098]
["Q13636","ras-related protein rab-31 [OS=Homo sapiens]",8,1,1,1,194,21.6,7.06,4.1,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","RAB31","ENSG00000168461","Endocytosis","Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation","",22.7,26,25,22.4,22.6,33.1,0.943661971830986,-0.08365792904690951,0.7095747810873381,0.14900182811042806,0.7983808612942355,0.09778988245957401,6496]
["Q13642-1","Isoform 1 of Four and a half LIM domains protein 1 [OS=Homo sapiens]",58,14,55,14,280,31.9,8.32,169.98,"","","","FHL1","","","","",10991.9,10806.9,10627.6,10559.4,10081.4,9983.4,1.058848884215751,0.08249670684776372,0.04383207461348063,1.3582079732916499,0.22850829768183306,0.6410980250383167,1402]
["Q13813","Spectrin alpha chain, non-erythrocytic 1 [OS=Homo sapiens]",71,168,1089,1,2472,284.4,5.35,3590.42,"cell organization and biogenesis","non-structural extracellular;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SPTAN1","ENSG00000197694","Apoptosis","Neutrophil degranulation; COPI-mediated anterograde transport; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Interaction between L1 and Ankyrins; RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Caspase-mediated cleavage of cytoskeletal proteins","Fas ligand pathway and stress induction of heat shock proteins",892.4,891.6,861.9,902.9,931,549.1,1.1103231221149812,0.15097958543597254,0.5164758273698764,0.2869499999634157,0.6586846662443598,0.18132244653719226,5731]
["Q13868","Exosome complex component Rrp4 [OS=Homo sapiens]",25,6,17,6,293,32.8,7.5,62.26,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","EXOSC2","ENSG00000130713","RNA degradation","ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; Major pathway of rRNA processing in the nucleolus and cytosol; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease","Ciliary landscape",1315.2,1377.8,1333.5,1268,1095.9,764.6,1.2870385168611158,0.3640552293573936,0.11473492486241647,0.9403043644326123,0.3576109022684017,0.4465892495997415,2345]
["Q13948","Protein CASP [OS=Homo sapiens]",35,22,48,5,678,77.4,5.44,118.09,"transport","other membranes;ER/Golgi;nucleus","","CUX1","ENSG00000257923","","Intra-Golgi traffic","",437.2,471.8,452.2,496.7,533.6,349.8,0.9863053401927397,-0.01989374991917898,0.9173492826033125,0.0374652743352649,0.9454182045329401,0.02437603938017211,7092]
["Q13951-2","Isoform 2 of Core-binding factor subunit beta [OS=Homo sapiens]",29,5,16,5,187,22,5.58,50.61,"","","","CBFB","","","","",1365,1428.1,1347.4,1534.1,1666.9,1018.2,0.9813471748198712,-0.027164480579805136,0.9016639215129664,0.044955307502862224,0.9345237666390062,0.029409649246173657,7052]
["Q14061","cytochrome C oxidase copper chaperone [OS=Homo sapiens]",32,2,7,2,63,6.9,7.24,22.8,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","mitochondrion;other cell component","other molecular function","COX17","ENSG00000138495","Oxidative phosphorylation; Metabolic pathways; Thermogenesis","Mitochondrial protein import","Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis; IL-18 signaling pathway; Mitochondrial complex IV assembly",598,636.5,611.8,544.4,616.7,614.4,1.0398760912419036,0.05641163105787625,0.419665994738001,0.3770962199616299,0.5885147266960954,0.23024266511820402,5212]
["Q14108-1","Lysosome membrane protein 2 [OS=Homo sapiens]",27,12,78,12,478,54.3,5.14,208.67,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SCARB2","ENSG00000138760","Lysosome","Cargo recognition for clathrin-mediated endocytosis","Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome",9349.8,9645.3,9575.2,8424.2,8813.4,6991.2,1.1791875784190715,0.2377932322528855,0.06140278503921812,1.211811930166101,0.26906052509091444,0.5701500145838478,1668]
["Q14141-1","Septin-6 [OS=Homo sapiens]",47,19,85,9,434,49.7,6.67,271.65,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component","other molecular function","SEPTIN6","ENSCANG00000016430; ENSCATG00000036060; ENSG00000125354; ENSMLEG00000030428; ENSMMUG00000017669; ENSMNEG00000026932; ENSPANG00000000899; ENSPPAG00000040865; ENSRBIG00000044672; ENSRROG00000038667","Bacterial invasion of epithelial cells; Shigellosis","","",12986.2,12720.6,12583.8,13888.8,13526.6,11628.1,0.9807163804474497,-0.02809212019863802,0.741895241662665,0.12965741437027994,0.822839502475329,0.08468486708031685,6590]
["Q14147","Probable ATP-dependent RNA helicase DHX34 [OS=Homo sapiens]",9,6,8,6,1143,128,7.56,16.79,"RNA metabolism OR transcription;other metabolic processes;other biological processes","","other molecular function","DHX34","ENSG00000134815","","","",424.6,452,447.1,500,514.5,436.4,{"$f":"AVERAGE(S2946:U2946)/AVERAGE(V2946:X2946)","v":0.9123302777586325},{"$f":"LOG(Y2946,2)","v":-0.13237189788147646},{"$f":"TTEST(S2946:U2946,V2946:X2946,2,2)","v":0.17071280186421559},{"$f":"-LOG10(AA2946)","v":0.7677339096379555},{"$f":"AA2946*7309/AE2946","v":0.42210415048225697},{"$f":"-LOG10(AC2946)","v":0.3745803774767707},2956]
["Q14164","Inhibitor of nuclear factor kappa-B kinase subunit epsilon [OS=Homo sapiens]",6,4,5,3,716,80.4,7.84,15.39,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","IKBKE","ENSG00000263528","Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Alcoholic liver disease; Hepatitis C; Hepatitis B; Measles; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease; Chemical carcinogenesis; Lipid and atherosclerosis","Negative regulators of DDX58/IFIH1 signaling; SUMOylation of immune response proteins; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; TICAM1-dependent activation of IRF3/IRF7","Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Cardiac hypertrophic response; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Ebola virus pathway in host; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; STING pathway in Kawasaki-like disease and COVID-19; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Toll-like receptor signaling pathway",314.3,342.5,329.7,353.5,377.3,376.7,0.8907449209932279,-0.16691574271882215,0.02343643702427103,1.630108412206603,0.17605027565302875,0.754363290590982,973]
["Q14197","Peptidyl-tRNA hydrolase ICT1, mitochondrial [OS=Homo sapiens]",8,2,3,2,206,23.6,10.07,7.23,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL58","ENSG00000167862","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",595.7,563.4,651.3,678.9,597.1,447.5,1.0504206556425877,0.07096719101226054,0.7097171860592953,0.1489146780452466,0.7982953082344398,0.0978364231702376,6498]
["Q14204","Cytoplasmic dynein 1 heavy chain 1 [OS=Homo sapiens]",44,185,631,185,4646,532.1,6.4,1919.08,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","DYNC1H1","ENSG00000197102","Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection","Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; COPI-mediated anterograde transport; Neutrophil degranulation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; HCMV Early Events; COPI-independent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Aggrephagy","Ciliary landscape; Intraflagellar transport proteins binding to dynein",69935.3,69352.6,70045.9,64816.8,62724.8,66577,1.0783809485541314,0.10886691417945694,0.011053551137318792,1.956498175229507,0.12022381735515333,0.9200094863993593,672]
["Q14247-1","Src substrate cortactin [OS=Homo sapiens]",4,2,2,2,550,61.5,5.4,3.99,"cell adhesion;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","CTTN","ENSG00000085733; ENSG00000288401","Tight junction; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Proteoglycans in cancer","Clathrin-mediated endocytosis; RHO GTPases activate PAKs","Pathogenic Escherichia coli infection; Hepatitis C and hepatocellular carcinoma",108.8,107.1,98.6,104,124.9,147.4,0.835769332979006,-0.25882327230122987,0.18613214630737146,0.7301786147345842,0.434229127788247,0.36228104773231645,3133]
["Q14331","Protein FRG1 [OS=Homo sapiens]",24,6,20,6,258,29.2,9.01,52.02,"RNA metabolism OR transcription;other metabolic processes;developmental processes","cytoskeleton;nucleus","cytoskeletal activity","FRG1","ENSG00000109536; ENSG00000275145; ENSG00000283153; ENSG00000283630","","","",3038.7,3045.3,3005.6,3293.6,3663.9,2507.4,0.9603482340014158,-0.05837045533634679,0.7324491888810108,0.13522249760045904,0.8167003999284986,0.08793723174258913,6555]
["Q14376","UDP-glucose 4-epimerase [OS=Homo sapiens]",40,12,41,12,348,38.3,6.73,131.26,"other metabolic processes","cytosol","other molecular function","GALE","ENSG00000117308","Galactose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars","Galactose catabolism; Defective GALE can cause Epimerase-deficiency galactosemia (EDG)","",4278.1,4228.2,4129,3726.5,3343.9,2820,1.2775317479576156,0.3533591440410844,0.026415793076806852,1.5781363460328615,0.1854688103730848,0.7317291136594246,1041]
["Q14498-1","RNA-binding protein 39 [OS=Homo sapiens]",31,13,35,13,530,59.3,10.1,115.7,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","LOC101348913; LOC111141906; LOC112827340; Rbm39; RBM39","ENSAMEG00000009940; ENSANAG00000024610; ENSBIXG00000021585; ENSBIXG00005010311; ENSBMUG00000009739; ENSCAFG00000008327; ENSCCAG00000031689; ENSDLEG00000014321; ENSECAG00000013423; ENSFCAG00000003233; ENSG00000131051; ENSGGOG00000003950; ENSHGLG00000017871; ENSLAFG00000010346; ENSLCNG00005002645; ENSMMUG00000031284; ENSMNEG00000040217; ENSMPUG00000017786; ENSOCUG00000007050; ENSPCOG00000027976; ENSPCTG00005007206; ENSPPAG00000029710; ENSPPYG00000010963; ENSPTRG00000049720; ENSRBIG00000044413; ENSRFEG00010016851; ENSRROG00000037484; ENSSSCG00000007309; ENSSSCG00070008152; ENSSSUG00005008586; ENSTTRG00000017039; ENSUAMG00000010443; ENSUMAG00000004302; ENSVVUG00000001290","","","mRNA Processing; VEGFA-VEGFR2 signaling pathway; mRNA processing; mRNA Processing",5311.1,5383.2,5367.4,5212.6,6166.1,4166.8,1.0332057508603776,0.047127578683395496,0.7806736091673814,0.10753050180183507,0.8496044385652756,0.07078322738387326,6716]
["Q14554","Protein disulfide-isomerase A5 [OS=Homo sapiens]",40,16,47,16,519,59.6,7.91,140.49,"other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","PDIA5","ENSG00000065485","","XBP1(S) activates chaperone genes","",4569.2,4323.9,4472.4,4043,3801.8,3816.4,1.1461513394847869,0.19679755221768813,0.00580109907751407,2.2364897171129594,0.08688572368350479,1.0610515772316969,488]
["Q14596-1","Next to BRCA1 gene 1 protein [OS=Homo sapiens]",7,4,4,4,966,107.3,5.12,7.5,"other metabolic processes;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","NBR1","ENSG00000188554","Mitophagy","Pexophagy","",178.1,218.2,177.2,229.7,259.2,444.7,0.6142887746358183,-0.7030110748041608,0.15522485526291244,0.8090387364331646,0.40752100111947814,0.3898500054877161,2784]
["Q14671-3","Isoform 3 of Pumilio homolog 1 [OS=Homo sapiens]",12,12,15,8,1188,126.6,6.84,37.44,"","","","PUM1","","","","",1158.9,1062.6,1084.2,1799.8,1716.3,1951.3,{"$f":"AVERAGE(S3010:U3010)/AVERAGE(V3010:X3010)","v":0.6046201119362037},{"$f":"LOG(Y3010,2)","v":-0.7258991256669656},{"$f":"TTEST(S3010:U3010,V3010:X3010,2,2)","v":6.4636811320605177E-4},{"$f":"-LOG10(AA3010)","v":3.189520076429378},{"$f":"AA3010*7309/AE3010","v":0.028983463432043145},{"$f":"-LOG10(AC3010)","v":1.5378497189493625},163]
["Q14677-1","Clathrin interactor 1 [OS=Homo sapiens]",31,20,83,20,625,68.2,6.42,237.51,"cell organization and biogenesis;transport","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","CLINT1","ENSG00000113282","","Golgi Associated Vesicle Biogenesis","",9833.5,9671.2,9727.6,10207.1,10175.5,16984.9,0.7822920987489128,-0.3542207012523933,0.2973243440209464,0.5267695306163492,0.524787160214706,0.28001679923475425,4141]
["Q14692","ribosome biogenesis protein BMS1 homolog [OS=Homo sapiens]",16,16,27,16,1282,145.7,6.44,68.05,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","BMS1","ENSG00000165733","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",1683,1667.9,1694,3833.4,3706.4,4388.9,0.42292119007100515,-1.2415392478228906,3.9621204246110696E-4,3.4020723286588384,0.0233541436963567,1.6316360519371003,124]
["Q14764","major vault protein [OS=Homo sapiens]",62,42,250,42,893,99.3,5.48,824.62,"transport;signal transduction;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","MVP","ENSG00000013364","","Neutrophil degranulation","16p11.2 proximal deletion syndrome",27496.4,27288.7,27790.8,28437.7,28053.5,26598.7,0.9938139292501257,-0.00895233211058014,0.7819109153198599,0.10684272416378388,0.8498121754755177,0.07067705095425647,6725]
["Q14790-4","Isoform 4 of Caspase-8 [OS=Homo sapiens]",50,20,54,9,496,57.7,5.43,187.15,"","","","CASP8","","","","",5034.5,5127.5,5118.3,5193.2,5170.8,4414.9,1.0339267469162117,0.048133975203746286,0.5516639594629158,0.2583253878342727,0.6842205803011118,0.16480386704544894,5893]
["Q14849-1","StAR-related lipid transfer protein 3 [OS=Homo sapiens]",13,4,8,4,445,50.5,8.37,16.7,"cell organization and biogenesis;other metabolic processes;transport","other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","STARD3","ENSG00000131748","Cholesterol metabolism","Pregnenolone biosynthesis","",318.3,341.1,334.9,281.3,258.6,314.9,1.1631960692559664,0.21809429913415293,0.05848407950839347,1.232962341142694,0.2622454828999066,0.5812919836626789,1630]
["Q14966-1","Zinc finger protein 638 [OS=Homo sapiens]",19,29,48,29,1978,220.5,6.38,116.6,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF638","ENSG00000075292","","Transcriptional regulation of white adipocyte differentiation","",3914.6,3795.9,4073.8,4877,5079.3,5580.3,0.7584864127286537,-0.39880475813893485,0.005045364495445646,2.2971074532838474,0.08104740460925765,1.091260888056987,455]
["Q14999","Cullin-7 [OS=Homo sapiens]",2,3,3,1,1698,191,5.87,8.39,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","CUL7","ENSG00000044090","Ubiquitin mediated proteolysis","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; XBP1(S) activates chaperone genes","",37.1,38.7,43.4,45.8,42.9,94.5,0.6506550218340613,-0.620035267634782,0.27405677919374966,0.5621594505521065,0.5089128554692877,0.2933565784274374,3936]
["Q15006","ER membrane protein complex subunit 2 [OS=Homo sapiens]",34,8,35,8,297,34.8,6.57,87.91,"cell organization and biogenesis","other membranes;ER/Golgi;other cell component","","EMC2","ENSG00000104412","","","",2077.3,2045,1988.6,1963.4,1900.8,1417.7,1.1569510971430734,0.2103278848427908,0.18816703299766652,0.7254564629562298,0.43688463919312087,0.3596332247592838,3148]
["Q15011-3","Isoform 3 of Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein [OS=Homo sapiens]",22,4,10,4,232,26.2,5.77,25.63,"","","","HERPUD1","","","","",825.8,817.7,825.6,1239.3,1190.9,1768.9,0.5880069538710676,-0.7660948781658893,0.035711242811873226,1.4471950353589842,0.20897796133865607,0.6798995118491467,1249]
["Q15022","Polycomb protein suz12 [OS=Homo sapiens]",9,5,9,5,739,83,8.81,24.37,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","SUZ12","ENSG00000178691","","HCMV Early Events; Oxidative Stress Induced Senescence; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PRC2 methylates histones and DNA; Defective pyroptosis; PKMTs methylate histone lysines; SUMOylation of chromatin organization proteins; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6","Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Malignant pleural mesothelioma",1208.1,1129.9,1174.2,1606.7,1532.8,1417.3,0.7707601825842696,-0.375646050850999,4.2751378690669755E-3,2.3690498751324087,0.07547580358698194,1.1221922543693348,414]
["Q15042-1","Rab3 GTPase-activating protein catalytic subunit [OS=Homo sapiens]",39,31,82,31,981,110.5,5.55,233.69,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","RAB3GAP1","ENSG00000115839","","RAB GEFs exchange GTP for GDP on RABs; COPI-independent Golgi-to-ER retrograde traffic","",7428.6,7346.3,7328.4,7642.9,7442.1,7011.4,1.0003122680617658,4.5043725921219217E-4,0.9908645638485454,3.985702924298915E-3,0.9939924646128216,2.6169079462230265E-3,7286]
["Q15043","Zinc transporter ZIP14 [OS=Homo sapiens]",9,4,5,4,492,54.2,5.33,18.12,"other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle","transporter activity","SLC39A14","ENSG00000104635","Ferroptosis; Alzheimer disease; Parkinson disease","Zinc influx into cells by the SLC39 gene family","Nuclear receptors meta-pathway; NRF2 pathway; Zinc homeostasis; Ferroptosis",464.1,487.9,507.9,557,597.2,630.6,0.8179627969520394,-0.28989286770244727,0.01192784394958478,1.9234380513355407,0.1252594991774643,0.9021893290621299,696]
["Q15056-1","Eukaryotic translation initiation factor 4H [OS=Homo sapiens]",38,8,31,8,248,27.4,7.23,82.22,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","translation activity;nucleic acid binding activity","EIF4H","ENSG00000106682; ENSPTRG00000019287","","L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Ribosomal scanning and start codon recognition","Translation factors; 7q11.23 copy number variation syndrome",2498.1,2425.6,3618.8,3574,2889.1,2917.6,0.9106463270331638,-0.13503723987802363,0.5652615141053313,0.24775058252266444,0.6941358210006496,0.15855554317651377,5952]
["Q15061","WD repeat-containing protein 43 [OS=Homo sapiens]",30,17,45,17,677,74.8,5.57,106.65,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","WDR43","ENSG00000163811","Ribosome biogenesis in eukaryotes","rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol","",3983.4,3981.8,3950.9,4643.9,4496.7,5180.7,0.8320543526076544,-0.26525032171771984,0.018268850887942407,1.738288768943062,0.1561719662455802,0.8063969217872616,855]
["Q15102","Platelet-activating factor acetylhydrolase IB subunit gamma [OS=Homo sapiens]",41,8,32,8,231,25.7,6.84,85.33,"other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","other molecular function","PAFAH1B3","ENSG00000079462","Ether lipid metabolism; Metabolic pathways","COPI-independent Golgi-to-ER retrograde traffic","",3873.7,3803.2,3741.6,3711.7,3616.1,4676.9,0.951169125425875,-0.07222620835498099,0.597237291443456,0.22385308279148164,0.7144365569820328,0.1460363311500629,6110]
["Q15126","phosphomevalonate kinase [OS=Homo sapiens]",78,12,44,12,192,22,5.73,115.47,"other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle","kinase activity;other molecular function","PMVK","ENSG00000163344","Terpenoid backbone biosynthesis; Metabolic pathways; Peroxisome","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Cholesterol biosynthesis pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways",5741.5,5776.1,5470.6,6193.4,5898.1,4596.7,1.0179767740079817,0.025704645494395658,0.8512078915727789,0.06996435867376363,0.9010106414924607,0.04527007970444074,6905]
["Q15154-1","Pericentriolar material 1 protein [OS=Homo sapiens]",31,44,79,44,2024,228.4,5.02,213.04,"","","","","","","","",6260.4,6139.4,6099.9,8225.3,8400.7,8339,0.7410254356098537,-0.4324050311708271,6.8220424422259288E-6,5.166085583027832,0.006232788526278664,2.205317608135803,8]
["Q15185","Prostaglandin E synthase 3 [OS=Homo sapiens]",56,9,100,9,160,18.7,4.54,330.43,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","PTGES3","ENSG00000110958","Arachidonic acid metabolism; Metabolic pathways; Chemical carcinogenesis","HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Estrogen-dependent gene expression; Potential therapeutics for SARS; HSF1 activation; Aryl hydrocarbon receptor signalling; Synthesis of Prostaglandins (PG) and Thromboxanes (TX); Attenuation phase","Aryl hydrocarbon receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway",14153.3,14567.7,15599.7,15081.2,15758,10466.6,1.0729897496235394,0.10163629395284764,0.5898213794441043,0.2292794894879832,0.7100979183589126,0.1486817604769592,6071]
["Q15291-1","Retinoblastoma-binding protein 5 [OS=Homo sapiens]",36,14,34,14,538,59.1,5.1,104.98,"protein metabolism;other metabolic processes;stress response;other biological processes","nucleus","nucleic acid binding activity;other molecular function","LOC101350636; RBBP5","ENSANAG00000037817; ENSBIXG00000017360; ENSBIXG00005000379; ENSBTAG00000015946; ENSCANG00000035291; ENSCHIG00000014205; ENSCJAG00000017172; ENSCSAG00000014601; ENSG00000117222; ENSGGOG00000014796; ENSLCNG00005015908; ENSMFAG00000038790; ENSMLEG00000013766; ENSMMUG00000018803; ENSMNEG00000044153; ENSNLEG00000014409; ENSPANG00000015342; ENSPPAG00000004153; ENSPPYG00000000310; ENSPTRG00000001894; ENSRBIG00000028065; ENSRFEG00010013463; ENSRROG00000045061; ENSSSCG00070019803; ENSSSUG00005002678; ENSTSYG00000000255","Cushing syndrome","Formation of the beta-catenin:TCF transactivating complex; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Neddylation; PKMTs methylate histone lysines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Neddylation; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","",2390.7,2351.6,2440.5,2166.4,2120.1,3806.2,0.8875653366614356,-0.17207476985262227,0.6138309130559965,0.21195124390749412,0.726204296459417,0.138941185988953,6178]
["Q15293","Reticulocalbin-1 [OS=Homo sapiens]",48,12,47,12,331,38.9,5,138.54,"","ER/Golgi","other molecular function","RCN1","ENSG00000049449","","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","VEGFA-VEGFR2 signaling pathway",3047.5,2862.7,6581.8,6474.4,3947.3,3689.5,0.885254266114859,-0.17583620378552167,0.73737471274653,0.13231176000756792,0.8196915247854583,0.0863495552853904,6575]
["Q15365","Poly(RC)-binding protein 1 [OS=Homo sapiens]",71,18,365,11,356,37.5,7.09,1369.44,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PCBP1","ENSG00000169564","Spliceosome; Ferroptosis","mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA","Ferroptosis",31930.3,31930,32039.1,34548,34031,31053.3,0.9625332347040064,-0.055091739423764156,0.3171854927079488,0.4986866844722343,0.5370184772301131,0.2700107712445289,4317]
["Q15369-1","elongin-C [OS=Homo sapiens]",48,4,18,4,112,12.5,4.78,67.62,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","eloc; Eloc; ELOC; eloc.L; LOC101358566; LOC105890220; LOC107550711; LOC107664095; LOC107751353; LOC111156807; LOC113045545; LOC113937395; LOC115195324; Tceb1; TCEB1","ENSACCG00020004765; ENSACUG00000011303; ENSAMEG00000012854; ENSANAG00000026963; ENSBIXG00000018463; ENSBIXG00005018332; ENSBTAG00000050514; ENSCAFG00000008152; ENSCATG00000020385; ENSCATG00000034779; ENSCCAG00000008410; ENSCCAG00000023220; ENSCGRG00001001449; ENSCHIG00000015198; ENSCPOG00000032030; ENSCPRG00005018410; ENSCSAG00000013512; ENSDLEG00000009234; ENSECAG00000000064; ENSEGOG00005000341; ENSELUG00000027740; ENSFCAG00000032823; ENSG00000154582; ENSGAGG00000025908; ENSGALG00000035417; ENSGGOG00000002188; ENSHGLG00000016964; ENSHHUG00000007733; ENSLCNG00005018064; ENSLSDG00000013506; ENSMFAG00000038428; ENSMMDG00005018719; ENSMNEG00000033021; ENSMODG00000006970; ENSMPUG00000010207; ENSMUSG00000079658; ENSOCUG00000032655; ENSOMYG00000017295; ENSOMYG00000030379; ENSPANG00000016947; ENSPCOG00000017567; ENSPCTG00005011391; ENSPMRG00000007569; ENSPPAG00000004063; ENSPPYG00000018678; ENSPSIG00000003701; ENSPTRG00000045560; ENSPTRG00000046987; ENSPTXG00000006319; ENSRBIG00000038767; ENSRFEG00010008700; ENSRNOG00000031730; ENSRROG00000031208; ENSSANG00000000802; ENSSANG00000018252; ENSSBOG00000024839; ENSSFOG00015012880; ENSSFOG00015024826; ENSSGRG00000038413; ENSSGRG00000052876; ENSSHAG00000009970; ENSSHBG00005007386; ENSSRHG00000026121; ENSSRHG00000030142; ENSSSAG00000055027; ENSSSCG00070017636; ENSSSUG00005020214; ENSSTUG00000043851; ENSTMTG00000005512; ENSTSYG00000035894; ENSUAMG00000019951; ENSVURG00010016846; ENSVURG00010021344; ENSXETG00000011828","HIF-1 signaling pathway; Ubiquitin mediated proteolysis; Human immunodeficiency virus 1 infection; Pathways in cancer; Renal cell carcinoma","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Neddylation; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Inactivation of CSF3 (G-CSF) signaling; RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex ; TP53 Regulates Transcription of DNA Repair Genes; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Neddylation; Inactivation of CSF3 (G-CSF) signaling; Neddylation; Antigen processing: Ubiquitination & Proteasome degradation; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Inactivation of CSF3 (G-CSF) signaling; Neddylation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Antigen processing: Ubiquitination & Proteasome degradation; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Inactivation of CSF3 (G-CSF) signaling; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; TP53 Regulates Transcription of DNA Repair Genes; RNA Polymerase II Pre-transcription Events; RNA Polymerase II Transcription Elongation; Inactivation of CSF3 (G-CSF) signaling; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Inactivation of CSF3 (G-CSF) signaling; RNA Polymerase II Pre-transcription Events; Neddylation; Antigen processing: Ubiquitination & Proteasome degradation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA Polymerase II Transcription Elongation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Dual hijack model of Vif in HIV infection; VEGFA-VEGFR2 signaling pathway; Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2",1317.1,1303,1210.2,1690.6,1498.7,1803.2,0.7672108162243365,-0.3823050351110711,0.015126546533128794,1.8202602122809106,0.14066148678198265,0.8518247964363455,786]
["Q15393-1","Splicing factor 3B subunit 3 [OS=Homo sapiens]",41,40,162,40,1217,135.5,5.26,514.36,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","Sf3b3; SF3B3","ENSANAG00000028001; ENSBIXG00000000514; ENSBTAG00000010627; ENSCATG00000036562; ENSCCAG00000017736; ENSCJAG00000014773; ENSG00000189091; ENSGGOG00000003246; ENSHGLG00000010135; ENSMFAG00000045487; ENSMMUG00000017812; ENSMNEG00000033385; ENSPANG00000024075; ENSPPAG00000026807; ENSPTRG00000008308; ENSRBIG00000021904; ENSRROG00000045703; ENSSBOG00000029156; ENSSTOG00000007065; ENSTSYG00000007910","Spliceosome","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","mRNA Processing; mRNA processing; mRNA Processing",16531.1,16864.7,17178.9,17615.3,17328.4,16420.1,0.9846370400943856,-0.02233608296503349,0.5522814380044907,0.25783955302417966,0.6844057359062093,0.1646863593559859,5898]
["Q15435","Protein phosphatase 1 regulatory subunit 7 [OS=Homo sapiens]",44,13,38,13,360,41.5,4.91,122.15,"other biological processes","other cell component","enzyme regulator activity","PPP1R7","ENSG00000115685","","","",4028,3829.8,3872.1,3770.2,3464.7,2813.1,1.1673865445859872,0.22328234478135786,0.124017181901046,0.9065181415484176,0.36862203436955887,0.43341870840316177,2459]
["Q15438-1","Cytohesin-1 [OS=Homo sapiens]",32,13,35,9,398,46.4,5.54,109.11,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","CYTH1","ENSCATG00000038229; ENSG00000108669; ENSMFAG00000037544; ENSMMUG00000013313; ENSPANG00000019854; ENSPTRG00000009717","Phospholipase D signaling pathway; Endocytosis; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection","Intra-Golgi traffic","",2244.6,2320.9,2273.8,2761.8,2910.7,4420.9,0.677601204747657,-0.5614916551612811,0.11032125432964494,0.9573408089664848,0.3511925295711563,0.4544547308084477,2296]
["Q15542","Transcription initiation factor TFIID subunit 5 [OS=Homo sapiens]",16,8,24,8,800,86.8,5.64,63.3,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","TAF5","ENSG00000148835","Basal transcription factors","RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Regulation of TP53 Activity through Phosphorylation","Eukaryotic transcription initiation",1174.5,1083.1,1176.4,1224.8,1114.7,790.2,1.0972297664312873,0.13386566628925062,0.49130732677754185,0.3086467592616156,0.6393030534835417,0.1942932212537849,5617]
["Q15633","RISC-loading complex subunit TARBP2 [OS=Homo sapiens]",2,1,1,1,366,39,6.54,2.9,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TARBP2","ENSG00000139546","","MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis","Fragile X syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies",82.9,85.5,66.6,105.2,99.5,154.4,0.6544138123085491,-0.6117248962122962,0.08787003973733001,1.0561591771983834,0.3198416934462874,0.49506492378739203,2008]
["Q15637-5","Isoform 5 of Splicing factor 1 [OS=Homo sapiens]",24,12,53,12,673,71.7,9.58,169.22,"","","","SF1","","","","",5663.3,5805.1,6221.3,6633.8,7174.9,6158.3,0.8859468122401962,-0.17470800561114402,0.08808380454375665,1.0551039354455236,0.32030075990563056,0.4944420309820395,2010]
["Q15654-1","thyroid receptor-interacting protein 6 [OS=Homo sapiens]",3,1,1,1,476,50.3,7.37,2.8,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","TRIP6","ENSG00000087077","NOD-like receptor signaling pathway","","",21.4,20.8,27,20,19.7,23.4,1.0966719492868462,0.13313203265417553,0.4272251446486558,0.3693431945075977,0.5938738269754708,0.22630581439396869,5258]
["Q15696","U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 [OS=Homo sapiens]",10,4,6,4,482,58,9.72,17.05,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","ZRSR2","ENSG00000169249","","mRNA Splicing - Minor Pathway","",287.8,307.6,283.5,292.7,330.3,269.7,0.9845412792651508,-0.02247639902701643,0.8220484624946712,0.08510257859911312,0.8807317813505646,0.055156331786518575,6822]
["Q15771","Ras-related protein Rab-30 [OS=Homo sapiens]",55,11,24,9,203,23,4.97,71.5,"cell organization and biogenesis;signal transduction","other membranes;ER/Golgi;other cell component","other molecular function","RAB30","ENSG00000137502","","Intra-Golgi traffic; RAB geranylgeranylation","",2140.6,2219.5,2249.1,2138.6,2119.3,2121,1.0361034034081114,0.05116799157636222,0.08035479365420482,1.0949882098095314,0.30781613564915256,0.5117086182936347,1908]
["Q15811-8","Isoform 8 of Intersectin-1 [OS=Homo sapiens]",7,11,19,1,1716,194.7,7.77,55.22,"","","","ITSN1","","","","",1807.4,1710.1,1766.4,1830.6,1785,1324.4,1.0696153846153846,0.09709212143087009,0.5233390695346251,0.2812168420806543,0.6637316084033619,0.1780074997780374,5763]
["Q15843","NEDD8 [OS=Homo sapiens]",36,4,24,4,81,9.1,8.43,57.78,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","NEDD8","ENSG00000129559; ENSG00000285246","","Cargo recognition for clathrin-mediated endocytosis; UCH proteinases; Neddylation; Iron uptake and transport; TGF-beta receptor signaling activates SMADs","EGF/EGFR signaling pathway",2721.4,2901,2918.6,3109.4,3023.6,4198.4,0.8267030605726233,-0.27455886702202253,0.19448417611434526,0.7111157285582644,0.4417292862708979,0.3548438064373022,3218]
["Q15904","V-type proton ATPase subunit S1 [OS=Homo sapiens]",9,3,5,3,470,52,6.14,14.3,"transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","ATP6AP1","ENSG00000071553","Oxidative phosphorylation; Metabolic pathways; Lysosome; Phagosome; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Tuberculosis; Hepatitis B; Human papillomavirus infection; Rheumatoid arthritis","Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport; RHOA GTPase cycle","Hepatitis B infection; Oxidative phosphorylation",628.5,671.9,694.9,529.8,496.7,329.2,1.4717857933171055,0.5575677139174597,0.030602055619851798,1.5142493998460713,0.19899503961343132,0.7011577491951405,1124]
["Q16254","Transcription factor E2F4 [OS=Homo sapiens]",11,4,4,4,413,43.9,4.75,14.49,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","E2F4","ENSG00000205250","Cell cycle; Cellular senescence; TGF-beta signaling pathway","Cyclin D associated events in G1; G1/S-Specific Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest","Cell cycle; Adipogenesis; TGF-beta signaling pathway",396.9,404.8,404.6,512.9,538.4,462.5,0.7968688069758226,-0.32758587017593954,0.010296047336649015,1.987329469406098,0.11649196591883537,0.9337040255172089,646]
["Q16401","26S proteasome non-ATPase regulatory subunit 5 [OS=Homo sapiens]",46,16,61,16,504,56.2,5.48,181.89,"cell organization and biogenesis","cytosol;nucleus;other cell component","","PSMD5","ENSG00000095261","","Degradation of DVL; Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Parkin-ubiquitin proteasomal system pathway",7096.2,6900.1,7157.8,6357.4,6393.7,5341.4,1.1692192897609506,0.2255455360124183,0.044707242432099975,1.3496221168341804,0.23076640885326177,0.6368274083039578,1416]
["Q16540","39S ribosomal protein L23, mitochondrial [OS=Homo sapiens]",13,1,1,1,153,17.8,9.69,2.29,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus","nucleic acid binding activity;other molecular function","MRPL23","ENSG00000214026; ENSG00000288141","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",23,20.3,25.6,21.5,27,58.3,0.6451310861423222,-0.6323357589832624,0.33594530979132814,0.4737314178156933,0.5458924564839522,0.2628929070313337,4498]
["Q16563","Synaptophysin-like protein 1 [OS=Homo sapiens]",10,2,2,2,259,28.5,8.43,6.69,"cell-cell signaling","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","SYPL1","ENSG00000008282","","","",296.3,316.4,317.5,307,370.5,360.5,0.8961464354527938,-0.15819359872063182,0.16040591404257268,0.7947796236534367,0.4123836882649186,0.3846985214599059,2843]
["Q16629","serine/arginine-rich splicing factor 7 [OS=Homo sapiens]",37,11,91,10,238,27.4,11.82,225.6,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","nucleus;other cell component","other molecular function","SRSF7","ENSG00000115875","Spliceosome; Amyotrophic lateral sclerosis; Herpes simplex virus 1 infection","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Minor Pathway","mRNA processing",12560,11896,12309.4,11498.8,12349.7,12064.5,1.0237351376938713,0.033842507367148146,0.4197093768913659,0.37705132793721974,0.5884626579127169,0.23028109098026586,5213]
["Q16690","Dual specificity protein phosphatase 5 [OS=Homo sapiens]",6,1,1,1,384,42,8.35,3.41,"protein metabolism;other metabolic processes;developmental processes;signal transduction","nucleus;other cell component","other molecular function","DUSP5","ENSG00000138166","MAPK signaling pathway","Negative regulation of MAPK pathway; RAF-independent MAPK1/3 activation","Endoderm differentiation; VEGFA-VEGFR2 signaling pathway",14.8,18.4,19.1,34.1,31.9,62.5,0.40700389105058365,-1.2968855078342991,0.06300778034110611,1.2006058195848244,0.2712154690890133,0.5666855436087853,1698]
["Q16763","ubiquitin-conjugating enzyme E2 S [OS=Homo sapiens]",18,4,6,4,222,23.8,8.38,19.55,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","UBE2S","ENSG00000108106","Ubiquitin mediated proteolysis","APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; APC-Cdc20 mediated degradation of Nek2A; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; APC/C:Cdc20 mediated degradation of Securin; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","",572.7,621.5,522.2,533.5,584,2408.6,0.4867700859306316,-1.038687583790506,0.38390356650464597,0.41577785322228605,0.569389441473713,0.24459059049468215,4928]
["Q16774-1","guanylate kinase [OS=Homo sapiens]",47,8,28,8,197,21.7,6.55,84.33,"other metabolic processes;transport","cytosol;other cell component","kinase activity;other molecular function","GUK1","ENSG00000143774","Purine metabolism; Metabolic pathways","Interconversion of nucleotide di- and triphosphates; Abacavir metabolism","",3862.5,3921.4,3624.7,3237.1,3625.1,1651.9,1.3399654690454657,0.42219582286307805,0.18906845984774284,0.7233809135480723,0.43703395731408995,0.35948481726028964,3162]
["Q16854","Deoxyguanosine kinase, mitochondrial [OS=Homo sapiens]",3,1,3,1,277,32,8.66,8.22,"protein metabolism;other metabolic processes;other biological processes","cytosol;mitochondrion;other cell component","kinase activity;other molecular function","DGUOK","ENSG00000114956","Purine metabolism; Metabolic pathways","Purine salvage","",159.8,174.6,161.2,151.5,140.2,163.8,1.0880351262349066,0.12172513345118836,0.18209813311215153,0.7396945066117082,0.4304512467389119,0.36607602997402255,3092]
["Q16864-1","V-type proton ATPase subunit F [OS=Homo sapiens]",33,3,7,3,119,13.4,5.52,19.7,"transport","other membranes;cytosol;other cytoplasmic organelle","transporter activity;other molecular function","ATP6V1F","ENSCATG00000033101; ENSG00000128524; ENSGGOG00000023527; ENSMLEG00000037581; ENSPPAG00000012238; ENSPPAG00000027671; ENSPTRG00000019672; ENSPTRG00000040903","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis","ROS and RNS production in phagocytes; Amino acids regulate mTORC1; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Proximal tubule transport",877.4,1024.1,872.9,995.1,1154.3,1079.6,0.8592133787550327,-0.2189116372795079,0.08874628364655578,1.051849824476666,0.3215897804524919,0.4926977608054584,2017]
["Q17RN3-1","Protein Fam98c [OS=Homo sapiens]",5,2,3,2,349,37.3,7.18,6.77,"","other cell component","","FAM98C","ENSG00000130244","","","",172,166.2,178.6,173.7,190.4,409.7,0.6678728353579736,-0.5823546587492916,0.3233734687120051,0.49029561480883954,0.5391278929781126,0.2683081984011793,4384]
["Q29963","HLA class I histocompatibility antigen, Cw-6 alpha chain [OS=Homo sapiens]",46,14,120,3,366,40.9,6,477.31,"other biological processes","plasma membrane;other membranes","","HLA-C","ENSG00000228299","","","",11335.8,11874.3,11481.7,10055.8,10727.7,17440.5,0.9075920887400586,-0.13988406144479493,0.6444560146719347,0.19080671870955757,0.7504108668531417,0.12470088547629533,6277]
["Q2KHR3-1","Glutamine and serine-rich protein 1 [OS=Homo sapiens]",0,1,1,1,1735,189.9,7.08,0,"","","","QSER1","ENSG00000060749","","","",14,16.5,14.2,15.7,15.6,13.1,1.0067567567567568,0.00971515483321185,0.9359426904506982,0.028750743124088915,0.9572915091665481,0.018955793106537104,7146]
["Q2NKX8","Dna excision repair protein ercc-6-like [OS=Homo sapiens]",23,21,34,21,1250,141,5.31,102.91,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","ERCC6L","ENSG00000186871","","RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",2537.7,2511.3,2557.8,2524.6,2567.5,5268.8,0.7341833238425233,-0.4457877492907124,0.3690732785216573,0.4328873972608372,0.5611725801362166,0.2509035575055111,4807]
["Q2TAL8","Glutamine-rich protein 1 [OS=Homo sapiens]",6,4,7,4,776,86.4,5.87,22.38,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cell component","nucleic acid binding activity","QRICH1","ENSG00000198218","","","",699.6,604.3,651.7,759.8,692.5,536.7,0.9832076420311715,-0.024431965712968903,0.8839148587981241,0.05358956545630938,0.9216167907211825,0.035449621538995064,7010]
["Q2TB10","zinc finger protein 800 [OS=Homo sapiens]",21,12,19,12,664,75.2,9.47,45.09,"","nucleus","nucleic acid binding activity;other molecular function","ZNF800","ENSG00000048405","","","",1515.2,1411.8,1436.7,1635.6,1579.6,1762.9,0.8765794178501837,-0.19004329021379102,0.030660784175626597,1.5134167418889384,0.1990227988806881,0.7010971705202929,1126]
["Q32MZ4-3","Isoform 3 of Leucine-rich repeat flightless-interacting protein 1 [OS=Homo sapiens]",52,30,133,27,752,82.6,4.61,441.23,"","","","LRRFIP1","","","","",11167.9,10803.6,12862,14100.8,14601.2,13843.5,0.8187352363939782,-0.2885311080958414,0.018698797191108455,1.7281863287610932,0.15781698460717286,0.8018462588944669,866]
["Q32P28-1","Prolyl 3-hydroxylase 1 [OS=Homo sapiens]",4,3,6,3,736,83.3,5.14,16.19,"protein metabolism;other metabolic processes;developmental processes;other biological processes","ER/Golgi;nucleus;other cell component","other molecular function","P3H1","ENSG00000117385","","Collagen biosynthesis and modifying enzymes","Type I collagen synthesis in the context of osteogenesis imperfecta",648.5,616.2,685,687.9,732.5,557.1,0.9859418457648547,-0.020425540881460147,0.8771581564925378,0.05692209386390709,0.916795218905185,0.03772766022017328,6993]
["Q3B820-3","Isoform 3 of Protein FAM161A [OS=Homo sapiens]",5,3,4,2,716,83.4,8.66,10.04,"","","","FAM161A","","","","",59,63.9,66.1,86,83.5,90.5,0.7269230769230769,-0.46012538880738196,1.279939563881392E-3,2.8928105363618783,0.03964016217122497,1.401864577448012,236]
["Q3MHD2","Protein LSM12 homolog [OS=Homo sapiens]",18,4,11,4,195,21.7,7.74,27.54,"","","","LSM12","ENSG00000161654","","","",908.8,898.5,846.4,1263.9,1260.4,1284.1,0.6968018065329271,-0.5211797306051247,4.9029965013903159E-5,4.309538416651318,0.01156000046085865,1.9370421486016174,31]
["Q3SXM5","Inactive hydroxysteroid dehydrogenase-like protein 1 [OS=Homo sapiens]",9,3,13,3,330,37,8.72,40.46,"","cytoskeleton;mitochondrion;other cell component","other molecular function","HSDL1","ENSG00000103160","","","",1145.8,1158.5,1100.9,1079.3,900.2,901.6,1.1819096872722226,0.24111979972660919,0.04789744467073806,1.319687655583357,0.2389641113299826,0.6216673183895123,1465]
["Q460N5-1","Isoform 1 of Poly [ADP-ribose] polymerase 14 [OS=Homo sapiens]",3,3,3,3,1720,193.6,7.97,6.48,"","","","PARP14","","","","",49.9,43.7,53.6,46.5,52.5,57.8,0.9387755102040815,-0.09114788805819561,0.5035341538049833,0.2979710667072099,0.6487451313521282,0.1879258883879391,5673]
["Q49MG5","Microtubule-associated protein 9 [OS=Homo sapiens]",2,2,3,2,647,74.2,7.8,3.64,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;other cell component","cytoskeletal activity","MAP9","ENSG00000164114","","","",559.3,549.2,532.5,672.8,630.8,260.3,1.0492998273546903,0.06942697308390659,0.8543531171935399,0.06836259166241379,0.9029015230722359,0.04435961438032575,6916]
["Q4G0F5","Vacuolar protein sorting-associated protein 26B [OS=Homo sapiens]",25,9,32,7,336,39.1,7.36,93.1,"stress response;transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","VPS26B","ENSG00000151502","Endocytosis","","",2907.4,2727.4,2715.7,2717.9,2493.8,1622.7,1.2218336649888797,0.2890478964257089,0.2111074549024721,0.6754964300469599,0.45840296728525504,0.33875257980279205,3366]
["Q4KMP7","TBC1 domain family member 10B [OS=Homo sapiens]",21,13,41,13,808,87.1,9.19,100.53,"transport;other biological processes","plasma membrane;other membranes;cytosol","enzyme regulator activity","TBC1D10B","ENSG00000169221","","TBC/RABGAPs","",2635.4,2599.3,2611.5,2559.6,2741.8,4049.2,0.8391119286462903,-0.2530648311439926,0.3454220650310234,0.46164992381793696,0.5520861301796961,0.25799316331464583,4573]
["Q4KMQ1","Taperin [OS=Homo sapiens]",12,4,4,4,711,75.5,7.25,13.69,"cell organization and biogenesis;developmental processes;other biological processes","other cell component","other molecular function","TPRN","ENSG00000176058","","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea","",264,309.7,264.7,283.9,319.4,286.7,0.9420224719101123,-0.08616661920367219,0.41498724298361944,0.3819652536179681,0.5856616642145732,0.23235320275188917,5179]
["Q504Q3","PAN2-PAN3 deadenylation complex catalytic subunit PAN2 [OS=Homo sapiens]",7,6,10,6,1202,135.3,5.99,31.96,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PAN2","ENSG00000135473","RNA degradation","Deadenylation of mRNA","Ectoderm differentiation; Ectoderm differentiation",476.8,462.2,464.7,459.6,526,485.4,0.9542488103331068,-0.06756261206072535,0.32148382152801924,0.49284087778765645,0.5380639458548873,0.2691661078250236,4367]
["Q53EZ4-1","Centrosomal protein of 55 kDa [OS=Homo sapiens]",21,9,13,9,464,54.1,7.01,32.64,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cell component","other molecular function","CEP55","ENSG00000138180","","","",955.1,1030.6,865.2,978.3,1000.4,1511.2,0.8169001977134014,-0.2917682626106581,0.30339236869746716,0.5179953473273412,0.5281006960728238,0.27728326008130794,4199]
["Q53FT3","Protein Hikeshi [OS=Homo sapiens]",15,3,8,3,197,21.6,5.45,23.91,"cell organization and biogenesis;stress response;transport;developmental processes","cytosol;nucleus","other molecular function","HIKESHI","ENSG00000149196","","Regulation of HSF1-mediated heat shock response","",797,830.2,883.9,712.9,786.5,662.9,1.1613097165055726,0.21575278432922165,0.057169341461571085,1.2428368104313985,0.2600191143389067,0.5849947253107702,1607]
["Q53H47","Histone-lysine N-methyltransferase SETMAR [OS=Homo sapiens]",6,4,5,4,684,78,7.14,13.3,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SETMAR","ENSG00000170364","Lysine degradation; Metabolic pathways","","Histone modifications",353.1,355.9,344.9,350.6,392.1,510.5,0.8409671241621449,-0.2498786924275263,0.23871744956209695,0.6221158341497203,0.4805248798814009,0.31828412117863963,3631]
["Q53QZ3","Rho GTPase-activating protein 15 [OS=Homo sapiens]",23,10,14,10,475,54.5,9.39,36.96,"signal transduction;other biological processes","other membranes;cytosol;other cell component","enzyme regulator activity","ARHGAP15","ENSG00000075884","","RAC1 GTPase cycle; RAC3 GTPase cycle","Ectoderm differentiation; Ectoderm differentiation",979.6,973.7,956.7,1023.6,968.2,1111.1,0.9378323503819008,-0.09259804942794339,0.2019115098891427,0.694838923558266,0.4488355309549099,0.3479127705423059,3288]
["Q53S33","BolA-like protein 3 [OS=Homo sapiens]",7,1,1,1,107,12.1,9.64,2.1,"","cytosol;mitochondrion;nucleus","","BOLA3","ENSG00000163170","","","",77.5,86.8,70,69.6,75.2,54.8,1.1738476953907815,0.23124523352587487,0.21163574290448756,0.6744109829729268,0.45873239765388485,0.3384405870416585,3372]
["Q567V2-1","Mpv17-like protein 2 [OS=Homo sapiens]",5,1,1,1,206,23.2,9.25,0,"cell organization and biogenesis;other biological processes","other membranes;mitochondrion;translational apparatus;other cell component","","FKSG24; MPV17L2","ENSG00000254858; ENSGGOG00000008883; ENSPPAG00000039781; ENSPTRG00000010696","Peroxisome","","",133.3,124.6,128.1,160,183.3,496.3,0.45974273463554066,-1.1211013191367118,0.23573154897289472,0.6275822900767434,0.47767171927997987,0.32087047051113354,3607]
["Q56VL3","OCIA domain-containing protein 2 [OS=Homo sapiens]",55,9,40,9,154,16.9,9.03,115.42,"transport;other biological processes","ER/Golgi;other cytoplasmic organelle","","OCIAD2","ENSG00000145247","","","",3989.4,3980.4,3936.8,4296.2,4016.7,3990,0.9677880824846176,-0.04723692116779671,0.2540262775714965,0.5951213557658311,0.493928721141279,0.30633571959567063,3759]
["Q5BKT4","Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase [OS=Homo sapiens]",1,1,1,1,473,55.6,9.29,1.85,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","ALG10","ENSG00000139133","N-Glycan biosynthesis; Metabolic pathways","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein","",64,60.6,68.2,64.5,69.9,65.4,0.9649649649649649,-0.05145153156245686,0.4455837482419385,0.35107065755057465,0.6078334482830027,0.2162154049387918,5358]
["Q5F1R6","DnaJ homolog subfamily C member 21 [OS=Homo sapiens]",23,10,15,10,531,62,5.47,39.69,"other biological processes","cytosol;translational apparatus;nucleus","other molecular function","DNAJC21","ENSG00000168724","","","",1414.6,1353.5,1482.4,1381.4,1536.1,1555.5,0.950257098144422,-0.07361019824709798,0.32711313512635337,0.4853020165648338,0.5399435195660607,0.26765166688754605,4428]
["Q5GJ75","Tumor necrosis factor alpha-induced protein 8-like protein 3 [OS=Homo sapiens]",10,2,2,2,292,32.6,8.59,4.37,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","transporter activity;other molecular function","TNFAIP8L3","ENSG00000183578","","PI Metabolism","",55.5,57.5,46,53.8,50.9,74,0.8897593732512592,-0.16851286886977268,0.46223602997376506,0.3351362055273337,0.6204744064422862,0.20727612773515455,5445]
["Q5HYK3-1","2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial [OS=Homo sapiens]",24,6,13,6,327,37.1,6.95,36.6,"other metabolic processes","other membranes;mitochondrion;other cell component","other molecular function","COQ5","ENSG00000110871","Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways; Biosynthesis of cofactors","Ubiquinol biosynthesis","",792.8,776.2,757.9,724.6,672.4,2468.3,0.6019972576514112,-0.7321711799650443,0.43395869913938706,0.36255160133858483,0.5990187218148781,0.2225596038981157,5295]
["Q5JRA6-1","Transport and Golgi organization protein 1 homolog [OS=Homo sapiens]",40,63,179,63,1907,213.6,4.84,539.69,"cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","MIA3","ENSG00000154305","","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cargo concentration in the ER","Type I collagen synthesis in the context of osteogenesis imperfecta",16828.3,16643.6,17004.6,17858.1,18942.9,17829.9,0.9239551242977874,-0.11410531199629302,0.02205499843504525,1.6564929687017713,0.17112524794240525,0.7666859096106757,942]
["Q5JS54-1","Proteasome assembly chaperone 4 [OS=Homo sapiens]",30,3,5,3,123,13.8,6.52,15.87,"cell organization and biogenesis","other cell component","other molecular function","PSMG4","ENSG00000180822; ENSGGOG00000012606; ENSPTRG00000033938","","","",554.8,595.7,586.1,673.8,575.4,556.4,0.9617855560478511,-0.056212834690180916,0.5816683789956811,0.2353245449363017,0.7041096691088826,0.15235969173940767,6038]
["Q5JTJ3-1","Cytochrome c oxidase assembly factor 6 homolog [OS=Homo sapiens]",11,1,1,1,125,14.1,8.25,2.19,"cell organization and biogenesis;other metabolic processes","plasma membrane;other membranes;mitochondrion;nucleus","other molecular function","COA6","ENSG00000168275; ENSPTRG00000002122","Thermogenesis","Mitochondrial protein import","Mitochondrial complex IV assembly",17.2,15.8,20.5,15.8,17.9,30.8,0.8294573643410852,-0.2697602690221073,0.49521225947701947,0.30520861245862346,0.6415289621619169,0.192783732393998,5642]
["Q5JTW2-1","Centrosomal protein of 78 kDa [OS=Homo sapiens]",9,5,5,5,689,76.3,8.18,17.8,"cell organization and biogenesis","cytosol;cytoskeleton","","CEP78","ENSG00000148019","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","Ciliopathies",401,396.9,401.5,551.9,547.2,519.7,0.7409191994069682,-0.4326118762036399,1.6084742225176268E-4,3.793585894729719,0.017038171148378745,1.7685770235830012,69]
["Q5JWF2-1","Guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas [OS=Homo sapiens]",17,14,58,1,1037,111,5.03,185.46,"cell adhesion;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","GNAS","ENSG00000087460","","G alpha (i) signalling events; G alpha (z) signalling events; G alpha (s) signalling events; ADORA2B mediated anti-inflammatory cytokines production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Prostacyclin signalling through prostacyclin receptor; Glucagon-type ligand receptors; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation in glucagon signalling; Hedgehog 'off' state","Thyroid stimulating hormone (TSH) signaling pathway; Endothelin pathways; Corticotropin-releasing hormone signaling pathway; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; G protein signaling pathways; Thermogenesis; Hippo signaling regulation pathways; Purinergic signaling; Prostaglandin and leukotriene metabolism in senescence ; Calcium regulation in cardiac cells; Estrogen signaling pathway; Serotonin receptor 4/6/7 and NR3C signaling",5566,5867.5,5645.6,5142.9,5283.6,4193.7,1.1681851137467338,0.22426890565933502,0.08152659901851317,1.088700674421957,0.3092256939420409,0.5097244271934369,1927]
["Q5MNZ9","WD repeat domain phosphoinositide-interacting protein 1 [OS=Homo sapiens]",7,1,4,1,446,48.6,6.6,18.58,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport","other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","WIPI1","ENSG00000070540","Autophagy; Autophagy; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis","XBP1(S) activates chaperone genes; Macroautophagy","Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Alzheimer's disease",37.9,48.9,48.1,41,42.5,145.1,0.5901137357830272,-0.7609350552662105,0.41815196777120794,0.37866585513850853,0.5870673708105568,0.23131205702775248,5206]
["Q5PSV4","Breast cancer metastasis-suppressor 1-like protein [OS=Homo sapiens]",5,2,4,2,323,37.6,5.15,9.87,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","BRMS1L","ENSG00000100916","","","Genotoxicity pathway",418.8,403.6,416.7,420.3,470.5,1098.3,0.6229450505253633,-0.6828231849781515,0.31572674757825414,0.5006886242098632,0.5356654591572562,0.2711063569518342,4308]
["Q5RKV6","Exosome complex component MTR3 [OS=Homo sapiens]",42,12,34,12,272,28.2,6.28,112.9,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cytoplasmic organelle;other cell component","","EXOSC6","ENSG00000223496","RNA degradation","Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease","",3233,3248.7,3186.4,3278.4,3511.4,4961.6,0.8227189951835526,-0.2815283416176818,0.2579112934030624,0.5885296405869643,0.4968565217403751,0.3037690052556351,3794]
["Q5SRD1","Putative mitochondrial import inner membrane translocase subunit Tim23B [OS=Homo sapiens]",14,2,6,2,257,28,9.39,26.68,"","","","","","","","",570.7,607.3,604.8,782.6,655.4,874.7,0.7708738703679682,-0.37543326779559766,0.052356543399457944,1.2810290334752699,0.24995034337468197,0.6021462622895579,1531]
["Q5SSJ5-1","Heterochromatin protein 1-binding protein 3 [OS=Homo sapiens]",48,24,119,24,553,61.2,9.67,300.56,"cell organization and biogenesis;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HP1BP3","ENSG00000127483; ENSPPAG00000040189; ENSPTRG00000000296","","","",22263.2,22052.1,22129,18053.8,18472,15989.1,1.2652466252435024,0.33941862629213465,3.8113950378083823E-3,2.418916035785934,0.07198316881483582,1.1427690389208724,387]
["Q5SZL2","Centrosomal protein of 85 kDa-like [OS=Homo sapiens]",1,1,3,1,805,91.8,6.33,5.03,"developmental processes","cytoskeleton;other cell component","","CEP85L","ENSG00000111860","","","",580.9,701.1,651.4,550.5,695.9,240.7,1.300114316454845,0.3786384821241721,0.3438195125201153,0.46366947977419826,0.5512122871264581,0.25868111009218764,4559]
["Q5T0D9","Tumor protein p63-regulated gene 1-like protein [OS=Homo sapiens]",31,3,10,3,272,30.2,7.34,53.52,"other biological processes","other membranes;ER/Golgi;other cell component","","TPRG1L","ENSG00000158109","","","",399,419.8,414.5,391.5,387.6,441.3,1.0105703048180923,0.01516969270643719,0.8264971226577208,0.08275865402967779,0.8839431474254144,0.0535756666084488,6834]
["Q5T3I0","G patch domain-containing protein 4 [OS=Homo sapiens]",36,16,26,16,446,50.4,9.63,81.55,"","","","GPATCH4","","","","",2166.5,2218.3,2292.4,2980.1,3238.9,3530.2,0.6848972223361917,-0.5460405855744305,3.281422232867513E-3,2.483937883723595,0.06662198638896848,1.1763824226069093,360]
["Q5T4S7-1","e3 ubiquitin-protein ligase UBR4 [OS=Homo sapiens]",24,98,284,98,5183,573.5,6.04,848.76,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus","other molecular function","UBR4","ENSG00000127481","Human papillomavirus infection; Viral carcinogenesis","Neutrophil degranulation; Antigen processing: Ubiquitination & Proteasome degradation","",25985.8,25852,25956.5,24102.5,23574.9,25234.9,1.0669571526340549,0.09350224090127027,0.02960345949261538,1.5286575338477735,0.19581148002853016,0.7081618499849301,1105]
["Q5T5U3","rho GTPase-activating protein 21 [OS=Homo sapiens]",2,2,2,2,1957,217.2,7.8,7.72,"","","","","","","","",78.1,79.9,67.4,79.3,75,456.2,0.36920556920556924,-1.4375037797025443,0.3673283213245583,0.4349455858915661,0.5610872937431968,0.2509695661204555,4785]
["Q5T6V5","queuosine salvage protein [OS=Homo sapiens]",11,4,6,4,341,39,5.88,14.13,"RNA metabolism OR transcription;other metabolic processes","","","C9orf64","ENSG00000165118","","","",600.4,549.4,561.8,563.6,486.9,358.5,1.214762242725337,0.28067397242649017,0.17782051431582974,0.750018137965154,0.42781110570585895,0.36874794560794866,3038]
["Q5TAQ9-1","DDB1- and CUL4-associated factor 8 [OS=Homo sapiens]",20,12,20,12,597,66.8,5.39,49.73,"protein metabolism;other metabolic processes","cytosol;mitochondrion;nucleus;other cell component","","DCAF8","ENSG00000132716; ENSPPAG00000008803; ENSPTRG00000001546","","Neddylation","",2863,2781.7,2874.1,2433.9,2456.1,2119,1.2154087601655015,0.28144159538443747,0.011107619735577062,1.9543789965457787,0.12063238134819129,0.9185360988857826,673]
["Q5TC12-1","ATP synthase mitochondrial F1 complex assembly factor 1 [OS=Homo sapiens]",14,4,11,4,328,36.4,7.96,31.61,"cell organization and biogenesis","mitochondrion","","ATPAF1","ENSG00000123472","","","7q11.23 copy number variation syndrome",872.8,856.4,891,792,827.2,515.8,1.2272599531615926,0.2954408671061963,0.1775451473004059,0.7506911934240785,0.42785277995999565,0.368705641850769,3033]
["Q5TF39","Sodium-dependent glucose transporter 1 [OS=Homo sapiens]",6,2,2,2,518,56.2,5.43,6.55,"transport","plasma membrane;other membranes","transporter activity","MFSD4B","ENSG00000173214","","Cellular hexose transport","",219.5,220.8,216.4,206.2,205.9,270.3,0.9623388042203985,-0.05538319141618801,0.7101031753476457,0.14867854532495242,0.7983608842664116,0.09780074948045989,6501]
["Q5TGZ0","MICOS complex subunit Mic10 [OS=Homo sapiens]",10,1,2,1,78,8.8,8.5,5.26,"cell organization and biogenesis","mitochondrion","","MICOS10","ENSG00000173436","","Cristae formation","",400.4,400.4,415.6,350.9,305.7,184,1.447061622650488,0.5331263598788238,0.06672591991325057,1.1757054301220269,0.2794840966452426,0.5536428995332526,1745]
["Q5VIR6-4","Isoform 4 of Vacuolar protein sorting-associated protein 53 homolog [OS=Homo sapiens]",26,17,47,17,832,94.3,6.7,140.26,"transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","VPS53","ENSG00000141252; ENSG00000283883","","Retrograde transport at the Trans-Golgi-Network","",3906.8,3726.5,3871.6,3855.7,3837.7,3836.5,0.9978317244728923,-0.003131556617255259,0.8879639600710811,0.05160466064019091,0.9242564204157693,0.034207523885550366,7022]
["Q5VTE6-1","protein angel homolog 2 [OS=Homo sapiens]",11,5,8,5,544,62.3,7.81,15.84,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ANGEL2","ENSG00000174606; ENSPPAG00000031266; ENSPTRG00000001970","","","",598.3,582.2,555.3,566.8,553.2,427.7,1.1215351812366738,0.1654748767769259,0.24469696154679077,0.6113714233398946,0.48534330853337687,0.3139509536509919,3685]
["Q5VTY9-1","Protein-cysteine N-palmitoyltransferase HHAT [OS=Homo sapiens]",3,1,1,1,493,57.3,7.28,3.27,"protein metabolism;other metabolic processes;signal transduction","other membranes;ER/Golgi","other molecular function","HHAT","ENSG00000054392; ENSG00000280680","Hedgehog signaling pathway","Hedgehog ligand biogenesis; HHAT G278V doesn't palmitoylate Hh-Np","",71.6,76.5,61.7,51.6,65.1,56.5,1.2113163972286376,0.27657574785054295,0.10643196575368286,0.9729279165382968,0.3451247727123638,0.46202386636441156,2254]
["Q5VW32","BRO1 domain-containing protein BROX [OS=Homo sapiens]",27,10,25,10,411,46.4,7.65,66.72,"","other membranes","","BROX","ENSG00000162819","","","",4425.3,4257.6,4491.1,4128.8,3936.4,2853.4,1.2065649442236186,0.27090557173908597,0.1355417920991699,0.867926776526632,0.38338814181611175,0.4163613239657054,2584]
["Q5VYS8-1","terminal uridylyltransferase 7 [OS=Homo sapiens]",20,22,38,21,1495,171.1,6.83,111.51,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TUT7","ENSG00000083223","","Deadenylation of mRNA","",2934,2872.8,2921.2,3878.7,3931.4,3905.8,0.7449705101614045,-0.4247447776158668,2.035087904146457E-6,5.691416826998352,0.004958152497135485,2.3046801198340416,3]
["Q5VZE5","N-alpha-acetyltransferase 35, NatC auxiliary subunit [OS=Homo sapiens]",10,5,5,5,725,83.6,7.05,14.31,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","","NAA35","ENSG00000135040","","Retrograde transport at the Trans-Golgi-Network","",180.1,175.6,205.6,170.3,173.1,273.2,0.9103146286084983,-0.13556283014523476,0.6273104784176198,0.20251745806932253,0.7371402390280359,0.1324498808761682,6220]
["Q5W0Z9-1","Probable palmitoyltransferase ZDHHC20 [OS=Homo sapiens]",5,1,2,1,365,42.3,7.71,5.62,"protein metabolism;other metabolic processes;transport","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","ZDHHC20","ENSG00000180776; ENSPPYG00000005201","","","",77.8,58.4,71.2,64.9,73.8,185.9,0.6389402341343191,-0.646247105734746,0.37699395733612745,0.42366561084621657,0.5656844249989234,0.2474257785340135,4871]
["Q5XKP0","MICOS complex subunit MIC13 [OS=Homo sapiens]",75,5,22,5,118,13.1,9.42,65.16,"cell organization and biogenesis","other membranes;mitochondrion;nucleus","","MICOS13","ENSG00000174917","","Cristae formation","",2944.6,2771.2,2766.9,2745.9,2400.8,4536.8,0.8759952496514688,-0.19100504848882513,0.5794737676614057,0.23696621943767823,0.7030832947936942,0.15299322074634944,6024]
["Q63ZY3-1","KN motif and ankyrin repeat domain-containing protein 2 [OS=Homo sapiens]",3,2,3,2,851,91.1,5.63,9.86,"developmental processes;other biological processes","mitochondrion;other cell component","","KANK2","ENSG00000197256","","","",151.5,174.7,175.3,179.5,205.8,246.4,0.7938895045116351,-0.332989871380864,0.10736114762479067,0.9691528548087452,0.34614143272589104,0.46074641305128966,2267]
["Q66K14-1","TBC1 domain family member 9B [OS=Homo sapiens]",14,14,25,12,1250,140.4,5.25,84.37,"transport;other biological processes","other membranes","enzyme regulator activity;other molecular function","TBC1D9B","ENSG00000197226; ENSG00000284400","","","",1588.9,1623.2,1570.9,1432.5,1442.3,1248.5,1.1599932093226297,0.2141163597448801,0.02753373188495799,1.5601349209276603,0.18807854798799808,0.725660736728897,1070]
["Q676U5","Autophagy-related protein 16-1 [OS=Homo sapiens]",12,6,7,6,607,68.2,6.64,17.74,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","ATG16L1","ENSG00000085978; ENSG00000281089","Autophagy; Autophagy; NOD-like receptor signaling pathway; Shigellosis","Macroautophagy","Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; LDLRAD4 and what we know about it; Autophagy; Senescence and autophagy in cancer",471,454.2,437,404.9,438.9,602,0.9421773412643519,-0.08592945831628855,0.6745263916137244,0.17100105339314522,0.7733511209889743,0.1116232806151651,6375]
["Q68CZ6","HAUS augmin-like complex subunit 3 [OS=Homo sapiens]",4,3,4,3,603,69.6,5.55,2.05,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","non-structural extracellular;cytosol;cytoskeleton;mitochondrion;nucleus","","HAUS3","ENSG00000214367","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",236.1,265.5,251.8,238.9,259.9,73.6,1.3162124388539485,0.3963923612207251,0.36808767433075984,0.43404872495963515,0.5608406945348183,0.2511604815415594,4797]
["Q68DQ2","very large A-kinase anchor protein [OS=Homo sapiens]",5,13,14,13,2970,330.4,5.2,33.18,"developmental processes;other biological processes","other cell component","other molecular function","CRYBG3","ENSG00000080200","","","",959.3,980.2,996.6,1106.4,1246.4,1336.5,0.7958420296533217,-0.32944600287851983,0.020787241396088323,1.6822031405842313,0.16714405650606112,0.7769090619222256,909]
["Q69YH5-1","cell division cycle-associated protein 2 [OS=Homo sapiens]",23,18,40,17,1023,112.6,8.4,106.03,"cell cycle OR cell proliferation;other biological processes","cytosol;nucleus;other cell component","","CDCA2","ENSG00000184661","","","",4083.7,3944.2,3882.6,2862.2,2915.8,4265.1,1.185938604614113,0.2460293242924766,0.24982167430427862,0.6023698853277663,0.49124202784233856,0.3087044845395192,3717]
["Q6BCY4","NADH-cytochrome b5 reductase 2 [OS=Homo sapiens]",4,1,1,1,276,31.4,8.5,2.31,"other metabolic processes;transport","other membranes;ER/Golgi","other molecular function","CYB5R2","ENSG00000166394","Amino sugar and nucleotide sugar metabolism","Erythrocytes take up carbon dioxide and release oxygen","Oxidation by cytochrome P450",69.9,71.6,65.4,74,60.3,48.6,1.1312192454893384,0.177878570111293,0.35016610550377353,0.45572589396096536,0.5540948398196754,0.25641589432353906,4619]
["Q6DD87","Zinc finger protein 787 [OS=Homo sapiens]",14,3,5,3,383,40.5,7.84,20.81,"","","","","","","","",555.8,593,592.2,617.3,722.8,619.7,0.8883559546892541,-0.17079023006036867,0.1190898630647422,0.9241252041125831,0.362678253808417,0.44047848394021616,2400]
["Q6DT37","Serine/threonine-protein kinase MRCK gamma [OS=Homo sapiens]",4,5,5,5,1551,172.4,6.28,16.18,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction","cytosol;cytoskeleton;other cell component","kinase activity;other molecular function","CDC42BPG","ENSG00000171219","","","",389.3,363.5,420,499.8,468.7,724.4,0.6927757103195699,-0.5295397468316958,0.10256846273459609,0.9889861535106046,0.3398335875463114,0.46873369973080337,2206]
["Q6IA69","glutamine-dependent NAD(+) synthetase [OS=Homo sapiens]",14,8,12,8,706,79.2,6.44,32.21,"other metabolic processes","cytosol;other cell component","other molecular function","NADSYN1","ENSG00000172890","Nicotinate and nicotinamide metabolism; Metabolic pathways; Biosynthesis of cofactors","Nicotinate metabolism","NAD biosynthesis II (from tryptophan); NAD+ biosynthetic pathways",781,781.7,771.5,792.5,839.6,724.2,0.9906208886814072,-0.013595052272249036,0.8374813186666544,0.07702487180213174,0.8904787544565868,0.05037643771936528,6874]
["Q6IAN0","Dehydrogenase/reductase SDR family member 7B [OS=Homo sapiens]",23,6,11,6,325,35.1,9.55,27.45,"other metabolic processes","other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","DHRS7B","ENSG00000109016","","Plasmalogen biosynthesis","",1100.2,1155.4,1164.1,1030.5,1020,1536.2,0.953439094432208,-0.06878731258117118,0.7617789137159482,0.11817105291890273,0.8367661677712452,0.07739588756773343,6654]
["Q6IEG0-1","U11/U12 small nuclear ribonucleoprotein 48 kDa protein [OS=Homo sapiens]",2,1,1,1,339,39.9,6.95,1.64,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","other molecular function","SNRNP48","ENSG00000168566","","mRNA Splicing - Minor Pathway","",124,108,122.4,111.7,109.8,159.8,0.9294518751639128,-0.10554792717109697,0.628362413730481,0.2017898007129731,0.7377832742098128,0.13207119459677413,6225]
["Q6JQN1","Acyl-CoA dehydrogenase family member 10 [OS=Homo sapiens]",2,2,2,2,1059,118.8,8.06,3.95,"other metabolic processes","mitochondrion","other molecular function","ACAD10","ENSG00000111271","","Mitochondrial Fatty Acid Beta-Oxidation","",158,128,145.6,123.2,133.3,186.3,0.974706413730804,-0.03696035729353525,0.8700819334634762,0.06043984901859416,0.910831975320044,0.04056173161278122,6982]
["Q6KCM7-3","Isoform 3 of Calcium-binding mitochondrial carrier protein SCaMC-2 [OS=Homo sapiens]",14,6,14,6,515,56.8,8.46,36.72,"","","","SLC25A25","","","","",1157.5,1141.4,1130.9,1120.5,1208.3,2127.7,0.7696174127678671,-0.3777866541088511,0.34801839522457095,0.45839779992300295,0.5529709675426933,0.2572976697206041,4600]
["Q6NT16","MFS-type transporter SLC18B1 [OS=Homo sapiens]",2,1,1,1,456,48.8,5.22,2.8,"transport","other membranes","transporter activity","SLC18B1","ENSG00000146409","","","",72.8,83.3,72.5,71,63,59.7,1.1801755291688178,0.2390014496112246,0.07587538557392483,1.1198990889683835,0.29993141869108525,0.5229780382435836,1849]
["Q6NUK1","Calcium-binding mitochondrial carrier protein SCaMC-1 [OS=Homo sapiens]",32,14,38,14,477,53.3,6.33,111,"stress response;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","SLC25A24","ENSG00000085491; ENSG00000284468","","","",4455.7,4639.4,4686.7,3989.5,4226,3767.7,1.1500934641831897,0.20175110885176642,0.016139388323152933,1.7921129289022573,0.14617446004203816,0.8351285017403546,807]
["Q6NW29","RWD domain-containing protein 4 [OS=Homo sapiens]",11,2,3,2,188,21.2,5.31,8.35,"","","","RWDD4","ENSG00000182552","","","",296.8,303,285.8,378.6,393.2,504.5,0.6938807490401943,-0.5272403536273382,0.03138150767248551,1.50332619528981,0.1999716125354809,0.6990316513071047,1147]
["Q6NXR4","TELO2-interacting protein 2 [OS=Homo sapiens]",24,10,19,10,508,56.9,7.09,61.94,"","cytosol;cytoskeleton;nucleus","","TTI2","ENSG00000129696","","","",1447.2,1457.4,1440.8,1596.3,1613.9,1698.2,0.8852986716649012,-0.17576383806803286,4.1326181657054505E-3,2.3837747196125023,0.07439730584517522,1.1284427913057236,406]
["Q6P0N0","Mis18-binding protein 1 [OS=Homo sapiens]",3,3,3,3,1132,129,9.25,5.18,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","nucleic acid binding activity","MIS18BP1","ENSG00000129534","","Deposition of new CENPA-containing nucleosomes at the centromere","",183.6,171.6,166.6,202.9,206.1,571.1,0.5323946536067747,-0.9094320113417674,0.27975650835770677,0.5532198010964517,0.5140121467034889,0.2890266180008955,3978]
["Q6P1L8","39S ribosomal protein L14, mitochondrial [OS=Homo sapiens]",13,1,1,1,145,15.9,10.24,5.95,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL14","ENSG00000180992","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",44.9,34.5,44.5,34.3,45.7,52.2,0.9372163388804843,-0.09354598936708988,0.6804323718262151,0.16721503284450656,0.7779258885777892,0.10906177539439796,6393]
["Q6P1X5","Transcription initiation factor TFIID subunit 2 [OS=Homo sapiens]",6,6,9,6,1199,136.9,8.19,23.55,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","TAF2","ENSG00000064313","Basal transcription factors","Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation","",527.2,510.9,530.4,547,540.5,737.8,0.8593107982249495,-0.2187480706702414,0.2581912756521709,0.5880584367409161,0.49687204679876706,0.30375543525794185,3798]
["Q6P1X6","UPF0598 protein C8orf82 [OS=Homo sapiens]",24,4,5,4,216,23.9,9.14,16.32,"","","","C8orf82","ENSG00000213563","","","",294.3,289.7,301.1,283.5,230.3,341.8,1.0344787283777468,0.04890397987220739,0.7764310349138277,0.10989711364631508,0.8473845653554078,0.07191945069852164,6697]
["Q6P3X3","tetratricopeptide repeat protein 27 [OS=Homo sapiens]",25,16,26,16,843,96.6,5.59,62.23,"","","","TTC27","ENSG00000018699","","","",2113.2,2088.4,2139.8,2135.3,2182.2,1707.7,1.0524795857398925,0.07379225054825582,0.5253959659372097,0.27951326611016053,0.665416585519852,0.17690637853485028,5771]
["Q6P4E1","Protein CASC4 [OS=Homo sapiens]",32,16,37,16,433,48.8,5.82,88.85,"","","","","","","","",3591.7,3738,3642.6,4092.6,4348.4,5297.2,0.7986708593556651,-0.32432701902715894,0.06683019292387511,1.1750272851631023,0.27944043482872033,0.5537107515775136,1748]
["Q6P6C2-2","RNA demethylase ALKBH5 [OS=Homo sapiens]",24,6,10,6,394,44.2,9.09,30.01,"RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes","cytosol;ER/Golgi;nucleus","other molecular function","ALKBH5","ENSCSAG00000008183; ENSG00000091542; ENSMFAG00000001517; ENSMMUG00000018352; ENSMNEG00000037007; ENSPANG00000023682; ENSPPAG00000030479; ENSPTRG00000024216; ENSRBIG00000029698; ENSRROG00000033654","","Reversal of alkylation damage by DNA dioxygenases","",959.4,902.4,953.2,1064,1033.6,1287.4,0.8316100443131463,-0.26602091149476703,0.08146798897182753,1.089013004067629,0.3093244318935519,0.5095857760281753,1925]
["Q6PD62","RNA polymerase-associated protein CTR9 homolog [OS=Homo sapiens]",14,15,24,15,1173,133.4,6.77,58.56,"cell-cell signaling;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","nucleus;other cell component","other molecular function","CTR9","ENSG00000198730","","E3 ubiquitin ligases ubiquitinate target proteins; RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex","Endoderm differentiation",2159.4,2118.3,2165.5,2809.9,2564.6,3508.2,0.7253650354059015,-0.4632208897807755,0.0453380563364298,1.3435371022169322,0.23189352957520326,0.6347113691239294,1429]
["Q6PGP7","Tetratricopeptide repeat protein 37 [OS=Homo sapiens]",26,38,67,38,1564,175.4,7.53,178.13,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","","TTC37","ENSG00000198677","RNA degradation","mRNA decay by 3' to 5' exoribonuclease","",6125,6258.3,6150.7,6128.1,5979.8,6596.4,0.9908951417588467,-0.013195697887809221,0.7802697768521012,0.10775521482041606,0.8497976157073472,0.07068449175273524,6711]
["Q6PII5-1","Hydroxyacylglutathione hydrolase-like protein [OS=Homo sapiens]",2,1,1,1,290,31.5,8.21,2.02,"","","other molecular function","HAGHL","ENSG00000103253","","","Orexin receptor pathway",192.1,153.4,171.1,201.9,185.8,367.2,0.6843290502053252,-0.547237902890142,0.24969404181140462,0.6025918206414499,0.49138765525028444,0.3085757581612385,3714]
["Q6PJG6-1","BRCA1-associated ATM activator 1 [OS=Homo sapiens]",23,12,25,12,821,88.1,5.27,67.16,"cell cycle OR cell proliferation;other metabolic processes;stress response;other biological processes","nucleus;other cell component","","BRAT1","ENSG00000106009","","","",1213.3,1226,1257,1502.1,1409,1604.8,0.8185079386168871,-0.2889316855823458,0.009245979696653988,2.034047064568802,0.11133256277239537,0.9533777937600868,607]
["Q6PJI9-1","GATOR complex protein WDR59 [OS=Homo sapiens]",4,3,3,3,974,109.7,7.91,9.14,"stress response;other biological processes","other membranes;other cytoplasmic organelle;other cell component","","WDR59","ENSG00000103091","mTOR signaling pathway","Amino acids regulate mTORC1","",259.2,259.4,247.5,248.9,250.8,341,0.9112644225050552,-0.1340583518545234,0.4625916753273356,0.33480218693922587,0.6207238030048643,0.20710160032838495,5447]
["Q6Q0C0-1","E3 ubiquitin-protein ligase TRAF7 [OS=Homo sapiens]",2,1,1,1,670,74.6,7.15,3.82,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","TRAF7","ENSG00000131653","","Antigen processing: Ubiquitination & Proteasome degradation","",37.7,46.2,36.8,42.5,57.8,45.8,0.8261464750171117,-0.2755305020484767,0.2004930280404304,0.6979007249700555,0.44731487849435464,0.34938665617446335,3276]
["Q6QNY1","biogenesis of lysosome-related organelles complex 1 subunit 2 [OS=Homo sapiens]",21,1,3,1,142,16,4.86,11.69,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","BLOC1S2","ENSG00000196072","","","Genotoxicity pathway",71.3,86.1,56.7,83.3,114.1,26.1,0.9579418344519016,-0.06199003568517054,0.9136599835953112,0.03921539586563673,0.9432119802398489,0.025390691671432757,7080]
["Q6SZW1","Sterile alpha and TIR motif-containing protein 1 [OS=Homo sapiens]",8,4,6,4,724,79.3,6.55,17.3,"other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;other cell component","other molecular function","SARM1","ENSG00000004139","","","Regulation of toll-like receptor signaling pathway",300.7,301.6,326.5,316.3,305.4,528.7,0.8073713490959664,-0.30869570357373166,0.3698608601211797,0.4319616247072241,0.5616690269324127,0.2505195245006096,4813]
["Q6UW02","Cytochrome P450 20A1 [OS=Homo sapiens]",35,13,34,13,462,52.4,6.21,71.7,"","other membranes","other molecular function","CYP20A1","ENSG00000119004","","","Oxidation by cytochrome P450; Metapathway biotransformation Phase I and II",2910.5,2979.4,3033.2,2653.4,2775.9,2638.3,1.1060414497496156,0.14540545268626318,7.11268952426244E-3,2.1479661482601764,0.09680939987492397,1.014082472075759,537]
["Q6UWI2","Prostate androgen-regulated mucin-like protein 1 [OS=Homo sapiens]",7,1,3,1,310,32.3,4.68,13.41,"other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","","PARM1","ENSG00000169116","","","",88.7,86,90.5,123.1,111.3,254.9,0.5419987737584304,-0.8836385073204529,0.1800518684328884,0.7446023675118965,0.4295036247963385,0.36703316658848983,3064]
["Q6UWP7-1","Lysocardiolipin acyltransferase 1 [OS=Homo sapiens]",9,3,5,3,414,48.9,8.62,18.6,"other metabolic processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","LCLAT1","ENSG00000172954","Glycerolipid metabolism; Glycerophospholipid metabolism; Metabolic pathways","Synthesis of PA; Acyl chain remodeling of CL","",326.9,367.8,343.4,327,368.6,399,0.9483829709482916,-0.07645833669525365,0.47670644726100037,0.3217489743768362,0.630747180128648,0.2001446823994569,5524]
["Q6UXV4","MICOS complex subunit MIC27 [OS=Homo sapiens]",47,8,19,8,268,29.1,9.52,61.94,"cell organization and biogenesis","non-structural extracellular;other membranes;mitochondrion;other cell component","","APOOL","ENSG00000155008","","Platelet degranulation ; Cristae formation","",2065.8,2141.8,2123.3,1902.9,1916.6,1422.9,{"$f":"AVERAGE(S3842:U3842)/AVERAGE(V3842:X3842)","v":1.2076339081336795},{"$f":"LOG(Y3842,2)","v":0.27218317074980003},{"$f":"TTEST(S3842:U3842,V3842:X3842,2,2)","v":0.09129438479612367},{"$f":"-LOG10(AA3842)","v":1.0395559336053863},{"$f":"AA3842*7309/AE3842","v":0.32613424167882105},{"$f":"-LOG10(AC3842)","v":0.4866036010975548},2046]
["Q6V1X1","Dipeptidyl peptidase 8 [OS=Homo sapiens]",9,6,11,5,898,103.3,5.8,24.15,"protein metabolism;other biological processes","cytosol;other cell component","other molecular function","DPP8","ENSG00000074603","","","",391.1,368.7,394.1,426.3,409.7,484.3,0.8739680375672197,-0.19434757590113713,0.08185840685287389,1.086936711947512,0.3101623098432635,0.5084109777074235,1929]
["Q6Y1H2","Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 [OS=Homo sapiens]",9,2,10,2,254,28.4,9.55,22.85,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","HACD2","ENSG00000206527","Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism","Synthesis of very long-chain fatty acyl-CoAs","",1042.4,1103.4,1056.2,933.8,927,1353.2,0.9962663347853142,-0.005396621158836864,0.9788992779171675,0.009261991848684238,0.9859135761742562,0.006161153046253368,7257]
["Q6YHK3-1","CD109 antigen [OS=Homo sapiens]",2,2,2,2,1445,161.6,5.85,5.29,"developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol","enzyme regulator activity;other molecular function","CD109","ENSG00000156535","","Platelet degranulation ; Post-translational modification: synthesis of GPI-anchored proteins","",36.9,39.1,35.9,36.7,25.6,114.5,0.6329185520361992,-0.6599082384150374,0.4826223649135509,0.3163925565807996,0.6337561741202199,0.1980777966948508,5566]
["Q6ZMS4","Zinc finger protein 852 [OS=Homo sapiens]",18,7,10,3,543,62,8.12,25.13,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF852","ENSG00000178917; ENSG00000281626","","","",1199.6,1321.8,1258,1531.1,1638.5,658.2,0.9873556612153194,-0.018358234881306144,0.9612913500494029,0.017144965565501546,0.9754378005707464,0.010800418458218336,7203]
["Q6ZQN7","Solute carrier organic anion transporter family member 4C1 [OS=Homo sapiens]",5,2,2,2,724,78.9,7.53,6.93,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle","transporter activity","SLCO4C1","ENSG00000173930","","Neutrophil degranulation; Transport of organic anions","",95.9,98.9,119,117.3,143.8,202.2,0.6773149147420678,-0.5621013300651737,0.1289118134105096,0.8897072823059338,0.37404384446900146,0.42707748792007383,2519]
["Q6ZSR9","Uncharacterized protein FLJ45252 [OS=Homo sapiens]",15,4,6,4,355,38,5.26,18.58,"","","","","","","","",301.7,327.6,326.7,401.7,378.9,961.2,0.5488575037317718,-0.8654964544797068,0.24133962373961002,0.6173713686890961,0.4830096686508241,0.3160441756673845,3652]
["Q6ZT07","TBC1 domain family member 9 [OS=Homo sapiens]",2,3,3,1,1266,143.1,5.31,4.78,"transport;other biological processes","","enzyme regulator activity;other molecular function","TBC1D9","ENSG00000109436","","","",51.3,61.4,57.4,68.7,77.2,94.5,0.7075707154742096,-0.4990537550478006,0.04505310730205292,1.3462752504652218,0.23140770293092394,0.6356221886655332,1423]
["Q6ZVF9","G protein-regulated inducer of neurite outgrowth 3 [OS=Homo sapiens]",23,13,20,13,776,82.4,7.56,69.33,"cell organization and biogenesis;developmental processes","plasma membrane;other membranes","","GPRIN3","ENSG00000185477","","","",1574.5,1632.1,1672.2,2739.6,2930.8,3050.3,0.5594505028266079,-0.8379175999420906,1.7393515371125868E-4,3.7596126346740255,0.017414959431172463,1.7590775329105086,73]
["Q6ZVK8-1","8-oxo-dGDP phosphatase NUDT18 [OS=Homo sapiens]",24,6,8,6,323,35.5,6.23,28.93,"other metabolic processes","cytosol","other molecular function","NUDT18","ENSG00000275074; ENSPTRG00000020049","","","",356.5,378.6,376,372.8,349.9,1518.9,0.4956727337615987,-1.0125401944588635,0.3841841830108688,0.415460519152884,0.5696900372542991,0.24436137542363517,4929]
["Q70CQ3","ubiquitin carboxyl-terminal hydrolase 30 [OS=Homo sapiens]",2,1,1,1,517,58.5,8.27,2.23,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle","other molecular function","USP30","ENSG00000135093","Mitophagy","Ub-specific processing proteases; Pexophagy","",116,101.9,114.7,124.6,114.4,139.7,0.8782677581198839,-0.18726725259715019,0.14910245856180165,0.826515195373157,0.40169180598164694,0.3961070272507802,2713]
["Q70IA6-1","MOB kinase activator 2 [OS=Homo sapiens]",8,2,5,2,237,26.9,6.79,14.96,"other metabolic processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","MOB2","ENSCATG00000043655; ENSCSAG00000009929; ENSG00000182208","","","",660.3,636.9,643.1,687.7,671.8,722.1,0.9321195234435048,-0.101413134832675,0.045471795961976855,1.3422578924856108,0.23209033288134695,0.6343429485734745,1432]
["Q71RC2","La-related protein 4 [OS=Homo sapiens]",8,5,8,5,724,80.5,6.61,23.37,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity","LARP4","ENSG00000161813","","","",671.4,707.2,734.7,1382.8,1445.9,1287.4,0.5134229003182624,-0.9617804486842445,1.7601926211251103E-4,3.7544398039390634,0.01738547009162626,1.7598135617860666,74]
["Q76I76","Protein phosphatase Slingshot homolog 2 [OS=Homo sapiens]",3,2,2,2,1423,158.1,5.41,7.71,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SSH2","ENSG00000141298","Axon guidance; Regulation of actin cytoskeleton","","Regulation of actin cytoskeleton",89.6,95.6,96.4,90,90.1,236.6,0.67578593712503,-0.5653617660652516,0.40917885480958094,0.38808681747404034,0.5822991140582607,0.23485387065086422,5136]
["Q7L014","probable ATP-dependent RNA helicase DDX46 [OS=Homo sapiens]",46,46,192,45,1031,117.3,9.29,604.08,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus","other molecular function","DDX46","ENSG00000145833","Spliceosome","mRNA Splicing - Major Pathway","",23050.4,22513.8,23341.1,22540.3,22738.4,19559.7,1.0627236329088934,0.0877664649112426,0.2686697857062501,0.5707811710765429,0.5053287348757031,0.29642600545633363,3886]
["Q7L0Y3","Mitochondrial ribonuclease P protein 1 [OS=Homo sapiens]",38,16,56,16,403,47.3,9.36,174.21,"RNA metabolism OR transcription;other metabolic processes;other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","TRMT10C","ENSG00000174173","","tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion","",8257.4,8237,8120,6857,7254.7,5249.9,1.2712998925708623,0.34630439422209286,0.04638791156209559,1.3335951794854313,0.23447389046151915,0.6299055105599702,1446]
["Q7L2J0-1","7SK snRNA methylphosphate capping enzyme [OS=Homo sapiens]",30,13,34,13,689,74.3,9.57,115.51,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MEPCE","ENSG00000146834","","","IL-18 signaling pathway",2181.3,2171.1,2154.4,2596.3,2620.8,3753.8,0.725322988774816,-0.46330451970693315,0.09789808869668698,1.0092257870179542,0.3338950677947201,0.4763899961758099,2143]
["Q7L2Z9","Centromere protein Q [OS=Homo sapiens]",15,3,5,3,268,30.6,9.42,19.29,"cell cycle OR cell proliferation;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","","CENPQ","ENSG00000031691","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Deposition of new CENPA-containing nucleosomes at the centromere","",266.4,284.6,293,290.6,318.1,302.2,0.9265561532550223,-0.11004968251214049,0.11701482768852689,0.9317591025676057,0.3604135590288424,0.4431988789009717,2373]
["Q7L5D6","Golgi to ER traffic protein 4 homolog [OS=Homo sapiens]",20,7,23,7,327,36.5,5.41,65.88,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","GET4","ENSG00000239857","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",1725.7,1723.2,1688.2,1651.8,1477.8,1927.7,1.0157791707037354,0.022586795851630804,0.8496121518607503,0.07077928457672215,0.8997124337800962,0.04589627764821723,6902]
["Q7L8L6","FAST kinase domain-containing protein 5, mitochondrial [OS=Homo sapiens]",7,4,8,4,764,86.5,8.13,30.2,"RNA metabolism OR transcription;other metabolic processes;other biological processes","mitochondrion;other cell component","nucleic acid binding activity","FASTKD5","ENSG00000215251","","","",473.6,492.6,512.1,470,491.7,657.8,0.9128125964803951,-0.1316093944588302,0.47900366191954724,0.31966116644895765,0.63218450071686,0.19915615597454034,5538]
["Q7LBC6-1","Lysine-specific demethylase 3B [OS=Homo sapiens]",14,15,21,15,1761,191.5,7.18,59.58,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KDM3B","ENSG00000120733","Thermogenesis","HDMs demethylate histones","Thermogenesis",1167.3,1123.2,1210.4,1460.1,1442.7,1951.7,0.72116592851993,-0.47159685662580514,0.05556931652366877,1.2551649447986517,0.25576582775283063,0.5921574810057562,1588]
["Q7Z2E3-4","Isoform 4 of Aprataxin [OS=Homo sapiens]",33,7,22,7,254,29.1,8.59,61.07,"","","","APTX","","","","",1698.7,1675.5,1729,1682.1,1633.9,1614.5,1.035026873542237,0.04966822649058483,0.08583739339550885,1.0663234789630622,0.3167014176313852,0.49934999261763646,1981]
["Q7Z2Z1","Treslin [OS=Homo sapiens]",0,1,2,1,1910,210.7,8.78,0,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","TICRR","ENSG00000140534","","","",77.6,76.5,76.8,88.5,92.2,69.6,0.9224930083899321,-0.11639011791421663,0.4082563044568677,0.3890670999907104,0.5822332349805359,0.23490300783452925,5125]
["Q7Z392","trafficking protein particle complex subunit 11 [OS=Homo sapiens]",8,8,9,8,1133,128.8,7.14,27.94,"cell organization and biogenesis;transport;other biological processes","cytosol;ER/Golgi;other cell component","","TRAPPC11","ENSG00000168538","","RAB GEFs exchange GTP for GDP on RABs","Genes related to primary cilium development (based on CRISPR)",650.8,581.2,595.8,610.9,579.4,871.1,0.8866789560492869,-0.17351625908285662,0.45769558290708795,0.33942327880786394,0.6163037979859812,0.2102051559115904,5428]
["Q7Z3K3-1","Pogo transposable element with ZNF domain [OS=Homo sapiens]",11,13,34,13,1410,155.2,7.4,119.03,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","POGZ","ENSG00000143442; ENSPTRG00000001289","","","",2655.8,2703.9,2703.3,2664,2700.4,2824.5,0.9846255296804212,-0.022352948178845096,0.4578645386909374,0.33926299099341367,0.616190740801337,0.2102848319020683,5431]
["Q7Z3K6-1","Mesoderm induction early response protein 3 [OS=Homo sapiens]",5,2,2,2,550,61.4,4.51,6.44,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","MIER3","ENSG00000155545; ENSGGOG00000015237","","","",23.5,18.2,18.2,33.8,30,25,0.6745495495495497,-0.56800367356132,0.035982913078910654,1.4439036802655105,0.20939419720840605,0.6790353577827147,1256]
["Q7Z434","Mitochondrial antiviral-signaling protein [OS=Homo sapiens]",40,11,31,11,540,56.5,5.52,126.96,"stress response;signal transduction;other biological processes","other membranes;mitochondrion;other cytoplasmic organelle","other molecular function","MAVS","ENSG00000088888","NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; Hepatitis C; Hepatitis B; Measles; Influenza A; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease","Ovarian tumor domain proteases; TRAF6 mediated NF-kB activation; Negative regulators of DDX58/IFIH1 signaling; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10","Novel intracellular components of RIG-I-like receptor (RLR) pathway; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation",1322.9,1336.9,1392.9,1411.2,1440.1,2001.7,0.8350916958582321,-0.2599934758674033,0.23985226589586733,0.6200561743778903,0.4817477909955742,0.3171802680801527,3639]
["Q7Z4G4","tRNA (guanine(10)-N2)-methyltransferase homolog [OS=Homo sapiens]",3,2,2,2,463,53.4,7.78,4.86,"RNA metabolism OR transcription;other metabolic processes","other cell component","nucleic acid binding activity;other molecular function","TRMT11","ENSG00000066651","","tRNA modification in the nucleus and cytosol","",321.6,317.9,340.7,352.9,323.1,356.1,0.9497141749830444,-0.07443470815932765,0.2435986365623664,0.6133251468072156,0.48461144110896465,0.31460633689303213,3674]
["Q7Z4H8","KDEL motif-containing protein 2 [OS=Homo sapiens]",2,1,1,1,507,58.5,8.24,0,"protein metabolism;other metabolic processes","ER/Golgi;other cell component","other molecular function","POGLUT3","ENSG00000178202","","","",165.3,166,151.3,197.2,201.5,103.9,0.9602069239952249,-0.058582755664904014,0.8460860871729501,0.07258544632021587,0.8970181623363928,0.04719876350817175,6894]
["Q7Z5D8","NANOG neighbor homeobox [OS=Homo sapiens]",4,1,1,1,188,22.7,9.72,2.13,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NANOGNB","ENSG00000205857","","","Pre-implantation embryo",71.1,67.2,71.9,69,80.4,135.7,0.7372851631006665,-0.4397053699757742,0.29320425254109705,0.5328297351163825,0.523072951384642,0.2814377371855519,4097]
["Q7Z5U6","WD repeat-containing protein 53 [OS=Homo sapiens]",13,2,2,2,358,39,6.52,11.19,"","","","WDR53","ENSG00000185798","","","3q29 copy number variation syndrome",70.3,86.1,69,83.5,87.3,141.8,0.7210492642354446,-0.4718302628274435,0.21255688539721632,0.6725248222819739,0.4593667283761839,0.3378404636597238,3382]
["Q7Z5W3","Pre-miRNA 5'-monophosphate methyltransferase [OS=Homo sapiens]",3,1,1,1,292,33.2,6.7,2.56,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","BCDIN3D","ENSG00000186666","","MicroRNA (miRNA) biogenesis","",72.9,79.3,71,102.2,111.6,105.9,0.6981545198623709,-0.518381716951333,9.756255533132993E-4,3.01071683328899,0.03547685158789505,1.450054928825506,201]
["Q7Z6K3","Protein prenyltransferase alpha subunit repeat-containing protein 1 [OS=Homo sapiens]",4,1,1,1,402,46.4,6.99,2.39,"protein metabolism;other metabolic processes","other cell component","other molecular function","PTAR1","ENSG00000188647","","","",140.5,107,94.2,116,103.8,96,1.0820139328689042,0.11371907656903091,0.5952835789453294,0.22527609741094237,0.7127994230850938,0.1470326604737934,6104]
["Q7Z6L1-1","Tectonin beta-propeller repeat-containing protein 1 [OS=Homo sapiens]",9,6,7,6,1165,129.6,6.24,25,"cell organization and biogenesis;other metabolic processes","other membranes;nucleus;other cytoplasmic organelle;other cell component","other molecular function","TECPR1","ENSG00000205356","Shigellosis","","",327,329.6,316.2,298,373.1,370.7,0.9337684776348627,-0.0988632083071169,0.4093306602516367,0.3879257240100048,0.5824017511736836,0.23477732785036903,5137]
["Q7Z7A3","Cytoplasmic tRNA 2-thiolation protein 1 [OS=Homo sapiens]",10,2,3,2,348,36.4,9.2,9.81,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol","nucleic acid binding activity;other molecular function","CTU1","ENSG00000142544","Sulfur relay system","tRNA modification in the nucleus and cytosol","",258.2,263.9,298.8,319.8,318.2,540.9,0.696327084570362,-0.5221629548452883,0.1870232788445939,0.7281043333322894,0.43561285693917684,0.3608993106992343,3138]
["Q7Z7H8","39S ribosomal protein L10, mitochondrial [OS=Homo sapiens]",33,5,16,5,261,29.3,9.58,50.63,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus;other cell component","other molecular function","MRPL10","ENSG00000159111","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1283.6,1314.7,1362.5,1131.5,1042.9,1058.3,1.2252296841649395,0.29305222526430974,2.4418319289368023E-3,2.6122842318109907,0.056838692893627675,1.2453559180002327,314]
["Q7Z7L1","Schlafen family member 11 [OS=Homo sapiens]",21,12,30,10,901,102.8,7.77,80.77,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SLFN11","ENSG00000172716","","","",2564.9,2502,2422.3,2455.9,2255.5,2785.8,0.998932934962386,-0.001540271369162628,0.9875014761663501,0.005462246496012489,0.9918439314689917,0.00355665953349122,7277]
["Q86TG7-1","Retrotransposon-derived protein PEG10 [OS=Homo sapiens]",22,12,39,4,708,80.1,6.39,131.72,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PEG10","ENSG00000242265","","","",4319.9,4653.6,4332.7,1321.2,1361.4,2135.8,2.7615391001162215,1.4654725544031537,5.9144363058924161E-4,3.2280866408764894,0.027187808150797275,1.565625803312968,159]
["Q86TU7","Histone-lysine N-methyltransferase setd3 [OS=Homo sapiens]",15,8,12,8,594,67.2,5.96,42.46,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","cytoskeletal activity;other molecular function","SETD3","ENSG00000183576","","PKMTs methylate histone lysines","Histone modifications",1122.6,1083,1100.9,1100.7,1092,1005.9,1.0337335084099293,0.04786431365290307,0.3285192967326044,0.48343911554603897,0.5407989954546408,0.2669641237766858,4440]
["Q86U38","Nucleolar protein 9 [OS=Homo sapiens]",16,9,15,9,636,69.4,7.28,32,"RNA metabolism OR transcription;other metabolic processes;transport","nucleus;other cell component","","NOP9","ENSG00000196943; ENSG00000285326","","","",938,931.2,896.8,1059.3,1056.1,1537.4,0.7572273324572931,-0.4012016081868449,0.13915010358412855,0.8565164660385355,0.3884828522140549,0.41062814636929945,2618]
["Q86UD5","Sodium/hydrogen exchanger 9B2 [OS=Homo sapiens]",3,1,1,1,537,57.5,6.71,2.37,"transport;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle","transporter activity;other molecular function","SLC9B2","ENSG00000164038","","Stimuli-sensing channels","",22.9,32.2,28.7,31.7,38.2,54,0.6763518966908797,-0.56415403844125,0.13512950089914882,0.8692498272986909,0.3828145434387127,0.4170115713779482,2580]
["Q86UF1","Tetraspanin-33 [OS=Homo sapiens]",5,1,2,1,283,31.5,7.17,7.59,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","TSPAN33","ENSG00000158457","","Amyloid fiber formation","",48.4,49.5,51,57.5,46.6,26.1,1.1436251920122888,0.19361430541646446,0.5367134846932808,0.27025749311558694,0.6735643646331027,0.17162089753659474,5824]
["Q86UV5","Ubiquitin carboxyl-terminal hydrolase 48 [OS=Homo sapiens]",15,11,20,11,1035,119,6.05,67.89,"protein metabolism;other metabolic processes","cytosol;mitochondrion;nucleus","other molecular function","USP48","ENSG00000090686","","Ub-specific processing proteases","",2009.7,1953.8,1947.8,2196.3,2182.8,1684.5,0.9748829078435253,-0.03669914619738601,0.7795261682499759,0.10816930121175304,0.8496207521233334,0.0707748884205813,6706]
["Q86V42","Protein FAM124A [OS=Homo sapiens]",1,1,1,1,546,60.1,6.6,1.79,"","","","FAM124A","ENSG00000150510","","","",255.5,268.2,260.2,282.5,293.6,311.3,0.8833671399594321,-0.17891492777904694,0.019730124883047196,1.7048701658452932,0.1620308795170696,0.790402210606233,890]
["Q86V85","Integral membrane protein GPR180 [OS=Homo sapiens]",5,2,3,2,440,49.4,7.39,6.67,"signal transduction;other biological processes","other membranes","","GPR180","ENSG00000152749","","","",105.7,117,131.2,108.7,99,951.6,0.30527042180626235,-1.7118402838577533,0.3960542714158889,0.4022452985151804,0.5754991391210202,0.23995532168713488,5030]
["Q86VQ1","Glucocorticoid-induced transcript 1 protein [OS=Homo sapiens]",20,8,12,8,547,58,9.44,39.59,"","other cell component","","GLCCI1","ENSG00000106415","","","",1158.7,1185,1261.3,1477.9,1567,2213.3,0.6855958312730591,-0.5445697576364374,0.07787391553426189,1.108607988239872,0.30388705213022965,0.5172878037311364,1873]
["Q86VX9","Vacuolar fusion protein MON1 homolog A [OS=Homo sapiens]",12,4,4,4,555,62.1,6.3,15.8,"","","","","","","","",131.3,141.3,147.3,130,142.8,140.6,1.0157232704402517,0.022507399409569695,0.7409818211853694,0.13019244661679327,0.8228253009790132,0.08469236269117507,6582]
["Q86W56","Poly(ADP-ribose) glycohydrolase [OS=Homo sapiens]",17,12,21,12,976,111,6.43,67.22,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","PARG","ENSG00000227345","","POLB-Dependent Long Patch Base Excision Repair","",1132.5,1110.4,1099.3,1229.4,1247.5,1182.3,0.9133690424136423,-0.13073020282075265,0.008282660313431176,2.0818301494617293,0.10565089743607062,0.9761268095451464,573]
["Q86WN1-1","F-BAR and double SH3 domains protein 1 [OS=Homo sapiens]",9,6,7,6,690,76.9,5.34,16.03,"cell-cell signaling;cell organization and biogenesis","cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","FCHSD1","ENSG00000197948","","","",907.2,920.8,933.3,891.6,933.5,1271.5,0.8917199509139055,-0.16533739916349877,0.40613914018265324,0.39132515494177084,0.5809140852436424,0.2358880931925106,5110]
["Q86WU2","Probable D-lactate dehydrogenase, mitochondrial [OS=Homo sapiens]",3,1,1,1,507,54.8,6.65,3.44,"other metabolic processes","other membranes;mitochondrion","other molecular function","LDHD","ENSG00000166816","Pyruvate metabolism; Metabolic pathways","Mitochondrial protein import","Clear cell renal cell carcinoma pathways",43.4,54.6,46.6,50.7,55.8,70.2,0.8183361629881154,-0.2892344876004992,0.18663867000592688,0.7289983690018357,0.43499427266368607,0.36151646113026353,3136]
["Q86X95","Corepressor interacting with RBPJ 1 [OS=Homo sapiens]",8,4,5,4,450,52.3,9.86,9.3,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","CIR1","ENSG00000138433","Notch signaling pathway; Epstein-Barr virus infection","","Notch signaling pathway (Netpath)",299.2,274.8,264.9,367,392,259.9,0.8233388948866425,-0.2804417136501352,0.2242932524775344,0.6491837913115993,0.46865619850151485,0.32914563457028406,3498]
["Q86Y07","serine/threonine-protein kinase VRK2 [OS=Homo sapiens]",6,3,5,3,508,58.1,8.84,10.03,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;mitochondrion;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","VRK2","ENSG00000028116","","RAC1 GTPase cycle; RAC3 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOD GTPase cycle","",243.8,236.5,229.6,254.3,270.1,312.7,0.8480468283359215,-0.2377841636570238,0.07710271661805418,1.1129303198550675,0.30216823365220263,0.519751194115801,1865]
["Q86Y39-1","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [OS=Homo sapiens]",26,2,4,2,141,14.8,8.72,13.78,"cell organization and biogenesis","other membranes;mitochondrion","","NDUFA11","ENSG00000174886; ENSPPAG00000024786; ENSPTRG00000029161","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Nonalcoholic fatty liver disease; Oxidative phosphorylation",257.7,232.9,227.5,321.1,307.5,217.2,0.8490186805391345,-0.23613179785265156,0.27763290782000805,0.556529058254607,0.512041111091708,0.29069516870482365,3963]
["Q86YB8","ERO1-like protein beta [OS=Homo sapiens]",11,5,8,3,467,53.5,7.99,22.85,"other biological processes","other membranes;ER/Golgi","other molecular function","ERO1B","ENSG00000086619","Protein processing in endoplasmic reticulum","Insulin processing","",231.6,278.7,257.2,230.3,251.9,367,0.9037918040508715,-0.14593762076047354,0.5741023490254575,0.24101067614804528,0.7007538525429308,0.15443450593508704,5988]
["Q86YS6","Ras-related protein Rab-43 [OS=Homo sapiens]",39,7,20,6,212,23.3,5.64,58.4,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","RAB43","ENSG00000172780","","Retrograde transport at the Trans-Golgi-Network; RAB geranylgeranylation","",1483.5,1582.3,1524.1,1512.7,1567.4,1057.6,1.109287768567078,0.14963367427313612,0.4103460759740336,0.38684971525882267,0.5830519963635715,0.23429271329101534,5144]
["Q86YV0","RAS protein activator like-3 [OS=Homo sapiens]",38,35,96,33,1011,111.8,8.75,290.2,"signal transduction;other biological processes","other membranes;cytosol;other cell component","enzyme regulator activity;other molecular function","RASAL3","ENSG00000105122","Ras signaling pathway","Regulation of RAS by GAPs","Ras signaling",10703.3,10436.3,10614.7,11074.1,10704.5,15522.9,0.8512874817366594,-0.23228167926615503,0.2988685428455073,0.5245197938518568,0.5254823621981749,0.2794418564740985,4157]
["Q8IU85-1","calcium/calmodulin-dependent protein kinase type 1D [OS=Homo sapiens]",29,11,29,8,385,42.9,7.21,95.13,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","kinase activity;other molecular function","CAMK1D","ENSCATG00000031901; ENSG00000183049; ENSGGOG00000016547; ENSMMUG00000011956; ENSMNEG00000040028; ENSPPYG00000002093; ENSPTRG00000002296; ENSRBIG00000041279; ENSRROG00000039467","Calcium signaling pathway; Oxytocin signaling pathway; Aldosterone synthesis and secretion; Glioma","","",3167,3244.7,3286.8,3671.2,3658.7,3088,0.9309457760201193,-0.1032309560453826,0.28729013548832966,0.5416792858651169,0.518854361325476,0.2849545283727107,4047]
["Q8IUC8-1","Polypeptide N-acetylgalactosaminyltransferase 13 [OS=Homo sapiens]",3,2,2,1,556,64,6.83,4.33,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","GALNT13","ENSG00000144278; ENSGGOG00000034959; ENSMFAG00000043213; ENSMMUG00000055468; ENSPPAG00000035152; ENSPPYG00000012857; ENSPTRG00000012546","Mucin type O-glycan biosynthesis; Other types of O-glycan biosynthesis; Metabolic pathways","O-linked glycosylation of mucins","",119.4,141.2,118.3,109.7,130.6,110,1.0816443048815303,0.11322615170664577,0.4016715170665909,0.3961289634373143,0.5787141963807831,0.2375358638707455,5073]
["Q8IUR0","Trafficking protein particle complex subunit 5 [OS=Homo sapiens]",32,5,14,5,188,20.8,9.66,29.55,"transport","cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","TRAPPC5","ENSG00000181029","","RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport","",1192.5,1252.2,1203.2,1397.6,1278.5,743.8,1.0666686160414047,0.09311204097026046,0.7256958157676905,0.13924538097556385,0.8115224475896649,0.09069946261595,6536]
["Q8IV36","protein HID1 [OS=Homo sapiens]",3,2,2,2,788,88.7,6.06,5.21,"","other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","","HID1","ENSG00000167861","","","",128.5,134.4,134.7,181.7,155,280,0.6447219069239499,-0.6332510894157318,0.12743265943391996,0.8947192533648021,0.37137372719398765,0.43018882363950794,2508]
["Q8IV53-1","DENN domain-containing protein 1C [OS=Homo sapiens]",11,5,11,5,801,87,5.67,41.56,"transport","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","DENND1C","ENSG00000205744","","RAB GEFs exchange GTP for GDP on RABs","",641.8,613.6,631.1,622.4,643,821.5,0.9039723992524799,-0.1456493709963069,0.35382028866809384,0.45121726751457397,0.5549511780847849,0.25574522232060126,4660]
["Q8IVH4","methylmalonic aciduria type A protein, mitochondrial [OS=Homo sapiens]",10,4,5,4,418,46.5,9.29,14.05,"other metabolic processes","mitochondrion;other cell component","other molecular function","MMAA","ENSG00000151611","","Cobalamin (Cbl, vitamin B12) transport and metabolism; Propionyl-CoA catabolism; Defective MMAA causes MMA, cblA type; Defective MUT causes MMAM","",432.3,412.2,436,393.4,367.8,481.8,1.0301689460981496,0.042880956544983376,0.7412481399947131,0.130036383396377,0.8227460372393861,0.08473420081020666,6585]
["Q8IW19","Aprataxin and PNK-like factor [OS=Homo sapiens]",5,2,2,2,511,56.9,5.08,6.3,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","APLF","ENSG00000169621","","","",82.8,63.3,76.4,46.5,67.9,49,1.3616891064871481,0.4453973525954391,0.09036118564990418,1.0440180792364837,0.32454540831211287,0.4887245309137497,2035]
["Q8IW50","Protein FAM219A [OS=Homo sapiens]",9,1,2,1,185,20.4,4.73,6.09,"","","","FAM219A","ENSG00000164970","","","",189.9,219.3,211.6,178.8,195.6,109.2,1.2837055417700582,0.36031431293800453,0.17620770830608637,0.7539750970501111,0.4273066157960137,0.3692603831447511,3014]
["Q8IWD4-1","Coiled-coil domain-containing protein 117 [OS=Homo sapiens]",11,3,3,3,279,30.5,5.07,4.93,"","","","CCDC117; FLJ33814","ENSG00000159873","","","",169.3,188.9,200.3,258.9,274.9,282.1,0.6845201617845325,-0.5468350597910553,1.6443461960379037E-3,2.7840067420267682,0.0453529296107209,1.343394654079603,265]
["Q8IWJ2","GRIP and coiled-coil domain-containing protein 2 [OS=Homo sapiens]",30,44,73,43,1684,195.8,5.14,202.13,"cell organization and biogenesis;transport;other biological processes","cytosol;ER/Golgi;nucleus","other molecular function","GCC2","ENSG00000135968","Salmonella infection","Signaling by ALK fusions and activated point mutants; Retrograde transport at the Trans-Golgi-Network","Deregulation of Rab and Rab effector genes in bladder cancer",6556.9,6546.7,6496.6,7271.3,7332,7336.7,0.8933546034639925,-0.1626951500977629,1.0052369382612454E-5,4.997731561276948,6.1227306514595355E-3,2.2130548454406,12]
["Q8IWU5-1","Extracellular sulfatase Sulf-2 [OS=Homo sapiens]",7,5,7,5,870,100.4,9.17,19.82,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","SULF2","ENSG00000196562","","","",425.9,440.6,440.8,518,512.9,668.6,0.7692262430126507,-0.3785201122168683,0.06344240486466819,1.197620362896319,0.2716464775371176,0.5659959221270795,1707]
["Q8IWY9","Codanin-1 [OS=Homo sapiens]",5,3,5,3,1227,134,6.77,18.73,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","","CDAN1","ENSG00000140326","","","",191.3,214.4,187,201.2,174.2,1192.8,0.37794924116821843,-1.4037356023247671,0.38698565539374447,0.412305132910809,0.5715251879718889,0.2429646248379923,4949]
["Q8IWZ8-1","SURP and G-patch domain-containing protein 1 [OS=Homo sapiens]",9,5,9,5,645,72.4,7.61,25.73,"RNA metabolism OR transcription;other metabolic processes","nucleus","","SUGP1","ENSG00000105705","","mRNA Splicing - Major Pathway","mRNA processing",665.6,690.9,919.3,854.1,739.9,941.6,0.8975390440132514,-0.1559533956407031,0.4336346167452919,0.3628760556639165,0.5989106979953399,0.22263792929540688,5292]
["Q8IXH7","Negative elongation factor C/D [OS=Homo sapiens]",25,11,27,11,590,66.2,5.1,83.75,"other biological processes","nucleus","nucleic acid binding activity","NELFCD","ENSG00000101158","","RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat","Initiation of transcription and translation elongation at the HIV-1 LTR",2324.9,2285.1,2357.6,2418.7,2348.7,1712.3,1.0752966958346837,0.10473478311827422,0.5110101412580661,0.2915704809832625,0.6541108795893529,0.1843486273451376,5710]
["Q8IXS8","protein FAM126B [OS=Homo sapiens]",3,2,2,2,530,58.6,7.9,3.57,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol","","FAM126B","ENSG00000155744","","","",186.3,153.5,169.3,157.7,148.1,108.1,1.2300072481275672,0.2986668170335291,0.15092811780568607,0.8212298439202779,0.4031921100298828,0.3944879750843836,2736]
["Q8IXW5","Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 [OS=Homo sapiens]",14,7,8,7,612,69.5,7.78,26.92,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","RPAP2","ENSG00000122484","","RNA polymerase II transcribes snRNA genes","",689.7,670.6,681.8,836.7,786.7,879.1,0.8160239760239761,-0.2933165534960683,0.004905394815047691,2.309326032301137,0.0802092409467194,1.0957755935491005,447]
["Q8IY63-1","Angiomotin-like protein 1 [OS=Homo sapiens]",1,1,1,1,956,106.5,7.11,0,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","AMOTL1","ENSG00000166025","Tight junction","Signaling by Hippo","",126.4,153.6,127,148.7,150.8,161,0.8838219326818675,-0.1781723618250886,0.14106368033165934,0.8505847896614106,0.3911359785827383,0.4076722336994098,2636]
["Q8IY95","transmembrane protein 192 [OS=Homo sapiens]",12,3,11,3,271,30.9,7.99,29.51,"","other membranes;nucleus;other cytoplasmic organelle;other cell component","other molecular function","TMEM192","ENSG00000170088","","","",1503.4,1668.3,1602.7,1533.9,1651.9,1091,1.1163486719042273,0.15878769801215936,0.4025669651467629,0.3951618664148516,0.5789771641593251,0.2373385652452292,5082]
["Q8IYD1","eukaryotic peptide chain release factor GTP-binding subunit ERF3B [OS=Homo sapiens]",32,17,60,5,628,68.8,5.43,148.61,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","GSPT2","ENSG00000189369","mRNA surveillance pathway","Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Translation factors",271.4,284,270,296.8,291.9,319.8,0.9085305448541552,-0.13839307611444354,0.04591551685576578,1.3380405226103265,0.23337726891431995,0.6319414467732173,1438]
["Q8IYS1","Peptidase M20 domain-containing protein 2 [OS=Homo sapiens]",51,17,62,16,436,47.7,5.85,200.63,"protein metabolism;other biological processes","nucleus","other molecular function","PM20D2","ENSG00000146281","","","",7498.2,7372,7377.4,7518.8,7594,8671.3,0.9353980180036242,-0.0963477230252827,0.24328074431577584,0.6138922641408902,0.4843745465006825,0.31481868676090397,3671]
["Q8IYU8","calcium uptake protein 2, mitochondrial [OS=Homo sapiens]",12,4,5,4,434,49.6,9.09,13.56,"transport;other biological processes","other membranes;mitochondrion","other molecular function","MICU2","ENSG00000165487","","Processing of SMDT1","",335.2,326.3,326.2,322.9,277.7,225.7,1.195328573157449,0.25740724222928973,0.12947667160273724,0.8878084733345255,0.3744934676471731,0.4265557533704673,2527]
["Q8IZ81","ELMO domain-containing protein 2 [OS=Homo sapiens]",29,8,34,8,293,34.9,8.05,93.22,"stress response;other biological processes","","enzyme regulator activity","ELMOD2","ENSG00000179387","","","Lung fibrosis",3238.7,3217.9,3264,2962.8,2803.5,1942,1.2610562640270877,0.33463264523157915,0.1020690865039232,0.9911057720526197,0.34002869337154723,0.4684844334073391,2194]
["Q8IZN3-1","Probable palmitoyltransferase ZDHHC14 [OS=Homo sapiens]",2,1,1,1,488,53.4,8.24,1.87,"protein metabolism;other metabolic processes;transport","other membranes;ER/Golgi","other molecular function","ZDHHC14","ENSG00000175048; ENSGGOG00000012728; ENSPPYG00000017128","","","",22.6,30.7,23.9,34.8,28.9,36.3,0.7719999999999999,-0.37332724739400674,0.08764044980913357,1.057295402116315,0.3196427383507771,0.4953351574275502,2004]
["Q8IZT6-1","Abnormal spindle-like microcephaly-associated protein [OS=Homo sapiens]",3,8,10,8,3477,409.5,10.45,29.69,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","other molecular function","ASPM","ENSG00000066279","","","",720.5,683.8,665.5,638.8,603.1,725.2,1.0522088353413654,0.07342106946936933,0.43704045709605177,0.35947835826917146,0.6011156757461502,0.2210419464594572,5314]
["Q8N0X7","Spartin [OS=Homo sapiens]",1,1,1,1,666,72.8,5.91,1.7,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;other cell component","other molecular function","SPART","ENSG00000133104","Endocytosis","","",75.4,81.5,87.5,101.9,97.9,144.9,0.709022338265158,-0.4960970135485401,0.09637685431858722,1.0160272529089993,0.33195967399366355,0.4789146705903482,2122]
["Q8N0Z8","tRNA pseudouridine synthase-like 1 [OS=Homo sapiens]",10,3,5,3,303,33.2,9.85,13.95,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","PUSL1","ENSG00000169972","","","",324.5,334.9,334.7,293.3,273.7,457.8,0.9700429352068696,-0.04387949084616487,0.8695797760362981,0.06069056926441691,0.9106976046782207,0.040625805706356544,6979]
["Q8N141","Zinc finger protein 82 homolog [OS=Homo sapiens]",1,1,1,1,532,62.5,8.98,2.89,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZFP82","ENSG00000181007","Herpes simplex virus 1 infection","","",153.1,142.3,128.8,221.5,210.4,70.4,0.8445152299422657,-0.24380465414127422,0.6242237724508451,0.204659696023729,0.7342213635087267,0.13417298305871164,6214]
["Q8N1G4","Leucine-rich repeat-containing protein 47 [OS=Homo sapiens]",42,21,77,21,583,63.4,8.28,235.75,"","","other molecular function","LRRC47","ENSG00000130764","","","",7612.2,7587,7710.6,7737.4,7529.8,7690.3,0.9979222476314932,-0.003000681455372448,0.8388542031018985,0.07631351508376744,0.8914197979749602,0.04991772468578915,6878]
["Q8N1S5-1","zinc transporter zip11 [OS=Homo sapiens]",10,2,4,2,342,35.4,5.6,13.38,"transport","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","transporter activity","SLC39A11","ENSG00000133195","Alzheimer disease; Parkinson disease","","Nuclear receptors meta-pathway; NRF2 pathway; Zinc homeostasis",92.9,102,99,80.8,81.7,137.4,0.9799933311103701,-0.029156163217407705,0.9208568869910296,0.035807859509488706,0.9478303037624892,0.0232694102742609,7101]
["Q8N2K1-1","Ubiquitin-conjugating enzyme E2 J2 [OS=Homo sapiens]",5,1,1,1,259,28.9,8.4,4.48,"protein metabolism;other metabolic processes;stress response","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","UBE2J2","ENSG00000160087","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum; Parkinson disease; Pathways of neurodegeneration","Antigen processing: Ubiquitination & Proteasome degradation; E3 ubiquitin ligases ubiquitinate target proteins","Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway",92,83.3,81.7,128.6,135.8,173.8,{"$f":"AVERAGE(S4354:U4354)/AVERAGE(V4354:X4354)","v":0.5864901871291648},{"$f":"LOG(Y4354,2)","v":-0.769821124908982},{"$f":"TTEST(S4354:U4354,V4354:X4354,2,2)","v":0.013699587655508268},{"$f":"-LOG10(AA4354)","v":1.8632925044955952},{"$f":"AA4354*7309/AE4354","v":0.13440306869008045},{"$f":"-LOG10(AC4354)","v":0.8715908153599151},745]
["Q8N3C0","Activating signal cointegrator 1 complex subunit 3 [OS=Homo sapiens]",22,36,65,36,2202,251.3,7.09,177.2,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","cytosol;nucleus","other molecular function","ASCC3","ENSG00000112249","","ALKBH3 mediated reversal of alkylation damage","Mesodermal commitment pathway; VEGFA-VEGFR2 signaling pathway",6694.6,6660.1,6658.5,7283.3,6674.8,6988.6,0.9554345075835334,-0.06577111108572109,0.15194022758545161,0.8183272274181642,0.4036827057150366,0.39395985592387484,2751]
["Q8N3F8","MICAL-like protein 1 [OS=Homo sapiens]",8,6,7,6,863,93.4,7.25,21.62,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;other cytoplasmic organelle","other molecular function","MICALL1","ENSG00000100139","","","",776,783.1,790.8,846,838.7,786.6,0.95087605713592,-0.07267079103449044,0.10256636510772325,0.9889950353546637,0.3399807540010654,0.4685456672745481,2205]
["Q8N3Z6","Zinc finger CCHC domain-containing protein 7 [OS=Homo sapiens]",9,4,4,4,543,63,7.33,7.63,"","cytosol;nucleus","other molecular function","ZCCHC7","ENSG00000147905","RNA degradation","","",99.1,103.5,103.4,96.9,121.3,182.9,0.7629020194465219,-0.3904303132344951,0.28379616456867424,0.5469934782158113,0.516114995479582,0.28725352252387326,4019]
["Q8N488","RING1 and YY1-binding protein [OS=Homo sapiens]",30,5,8,5,228,24.8,9.63,24.08,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RYBP","ENSG00000163602","","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Transcriptional Regulation by E2F6","",738,750.4,759.1,544,600.8,385.1,1.4690502647231845,0.5548837596969485,0.021035918537471235,1.6770385196799924,0.16785101374495334,0.7750760314638698,916]
["Q8N4Q0","Prostaglandin reductase 3 [OS=Homo sapiens]",11,4,9,4,377,40.1,8.18,24.72,"other metabolic processes;other biological processes","other cytoplasmic organelle","other molecular function","ZADH2","ENSG00000180011","","","",682,681.8,720.8,654.7,688.5,809.7,0.9682753495285429,-0.046510728264115356,0.6651739583178129,0.17706476182813474,0.7658721583719116,0.11584371802697234,6348]
["Q8N554","Zinc finger protein 276 [OS=Homo sapiens]",2,1,1,1,614,67.2,8.51,1.62,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF276","ENSG00000158805","","","",55.6,58.7,56.2,85.2,80.4,81.3,0.690562980963953,-0.5341550972312471,1.3039669668199252E-4,3.884733410375217,0.01615371959404548,1.7917274601333886,59]
["Q8N584-1","Tetratricopeptide repeat protein 39C [OS=Homo sapiens]",2,1,1,1,583,65.8,6.99,4.74,"cell organization and biogenesis;developmental processes","","","TTC39C","ENSG00000168234","","","",52.7,48.4,57.5,59.5,54.5,193.7,0.5154371140721482,-0.9561316726295663,0.33762200328775155,0.4715692575586405,0.5463093252225317,0.2625613862360618,4517]
["Q8N5G2-1","macoilin [OS=Homo sapiens]",10,7,10,7,664,76.1,9.07,24.67,"developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","cytoskeletal activity","LOC111154705; MACO1","ENSANAG00000024751; ENSCAFG00000012804; ENSCAFG00040000254; ENSCATG00000033846; ENSCCAG00000030283; ENSCPOG00000012618; ENSCSAG00000000952; ENSG00000204178; ENSMMUG00000018014; ENSMNEG00000031369; ENSPANG00000000594; ENSPPAG00000042632; ENSPPYG00000001709; ENSPTRG00000029594","","RHOC GTPase cycle; RHOA GTPase cycle","",1158.7,1209.1,1183.6,1268.5,1476.8,1496,0.8373376087520336,-0.25611867011867506,0.03636879397719206,1.4392711003127552,0.20980230085185222,0.6781897533122234,1267]
["Q8N5U6-1","RING finger protein 10 [OS=Homo sapiens]",5,3,3,3,811,89.9,6.92,6.95,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RNF10","ENSG00000022840","","","",159.9,152.4,163.5,172.1,184.4,265.3,0.765197812801544,-0.3860953449159294,0.17337606630030686,0.7610108549054488,0.424951599124394,0.37166053213845157,2982]
["Q8N5X7","Eukaryotic translation initiation factor 4E type 3 [OS=Homo sapiens]",15,3,5,3,224,24.4,6.42,13.8,"protein metabolism;other metabolic processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity","EIF4E3","ENSG00000163412","","ISG15 antiviral mechanism","",717.9,737.7,780.6,743.5,754,869.7,0.9446603582291315,-0.08213237674391528,0.3816692733236571,0.4183128019663372,0.5683823795278341,0.24535939413733082,4908]
["Q8N6H7","ADP-ribosylation factor GTPase-activating protein 2 [OS=Homo sapiens]",28,14,36,14,521,56.7,7.99,94.25,"cell organization and biogenesis;transport","plasma membrane;other membranes;cytosol;ER/Golgi","enzyme regulator activity;other molecular function","ARFGAP2","ENSG00000149182","Endocytosis","COPI-dependent Golgi-to-ER retrograde traffic; CDC42 GTPase cycle; COPI-mediated anterograde transport","IL-18 signaling pathway",5187.3,5180.1,5079.9,6443.8,6159.8,5531.6,0.8517854779655036,-0.23143796120214724,0.030008680569008333,1.522753099350094,0.19706509099629999,0.7053903018008293,1113]
["Q8N6M3","fat storage-inducing transmembrane protein 2 [OS=Homo sapiens]",5,1,2,1,262,29.8,8.65,6.54,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","FITM2","ENSG00000197296","","Lipid particle organization","",244.1,213.9,216.4,243.9,233.8,112.4,1.1428571428571426,0.19264507794239555,0.5521329496099248,0.2579563347168096,0.6843377528741631,0.16472950061064326,5897]
["Q8N806","Putative E3 ubiquitin-protein ligase UBR7 [OS=Homo sapiens]",21,6,15,6,425,48,4.81,48.09,"protein metabolism;other metabolic processes","other cell component","other molecular function","UBR7","ENSG00000012963; ENSG00000278787","","","",1245.8,1155.3,1275.3,1509,1541.6,1218.8,0.8611046048625098,-0.215739591586079,0.14331532825523893,0.8437073572603168,0.3933502569348634,0.4052205618152851,2663]
["Q8N8Q9","Magnesium transporter NIPA2 [OS=Homo sapiens]",4,1,1,1,360,39.2,8.22,5.24,"transport","plasma membrane;other membranes;other cytoplasmic organelle","transporter activity","NIPA2","ENSG00000140157","","Miscellaneous transport and binding events","Prader-Willi and Angelman syndrome; 15q11.2 copy number variation syndrome",212.3,208.9,212.7,186.5,190.9,41.4,1.5136103151862468,0.5979938257252887,0.2182352893593415,0.6610750212323924,0.4639562914274075,0.3335229316994531,3438]
["Q8N8S7","Protein enabled homolog [OS=Homo sapiens]",12,6,8,6,591,66.5,6.93,18.75,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ENAH","ENSG00000154380","Rap1 signaling pathway; Axon guidance; Regulation of actin cytoskeleton","Generation of second messenger molecules; Signaling by ROBO receptors","Regulation of actin cytoskeleton",970.8,981.2,1005.8,1041.3,1148.5,876.3,0.9646782557646522,-0.05188024702660969,0.6746040033295269,0.17095108588805075,0.7733187986724454,0.11164143239213374,6376]
["Q8N9B5-1","Junction-mediating and -regulatory protein [OS=Homo sapiens]",9,7,7,7,988,111.4,6.18,11.21,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","JMY","ENSG00000152409","","Regulation of TP53 Activity through Methylation","",579,597.9,611.2,738.6,730.5,794.9,0.789796819787986,-0.34044653626273813,0.002064692577936164,2.685144603399855,0.05150456673083762,1.2881542618699917,293]
["Q8N9Q2","protein SREK1IP1 [OS=Homo sapiens]",5,1,1,1,155,18.2,9.85,0,"RNA metabolism OR transcription;other metabolic processes","","nucleic acid binding activity;other molecular function","SREK1IP1","ENSG00000153006","","","",397.6,359.8,378,421.7,376.5,11.6,1.4020745863176094,0.4875630985984197,0.4516599283409566,0.3451884387110889,0.6118966480526509,0.21332192584604542,5395]
["Q8N9R8-1","protein SCAI [OS=Homo sapiens]",7,4,6,4,606,70.4,8.6,11.07,"RNA metabolism OR transcription;other metabolic processes;other biological processes","other membranes;nucleus;other cell component","other molecular function","SCAI","ENSANAG00000024288; ENSCSAG00000013617; ENSG00000173611; ENSMMUG00000020633; ENSPPYG00000019606","","RHO GTPases Activate Formins","",576.3,529.8,587.1,569.2,571.3,1094.3,0.7576516914265258,-0.40039333163560853,0.3619266953766755,0.4413793825530237,0.5578494762775456,0.25348297031122013,4742]
["Q8NB14","Ubiquitin carboxyl-terminal hydrolase 38 [OS=Homo sapiens]",5,5,6,4,1042,116.5,6.21,13.72,"protein metabolism;other metabolic processes","cytosol;nucleus","other molecular function","USP38","ENSG00000170185","","","Integrated breast cancer pathway",349.2,386.6,371.3,264.9,284.5,332.3,1.2556425087898375,0.3284257761656609,0.02994538646316294,1.5236700777129804,0.19700344703803593,0.705526174769875,1111]
["Q8NB37","Glutamine amidotransferase-like class 1 domain-containing protein 1 [OS=Homo sapiens]",23,4,9,4,220,23.3,6.61,30.33,"","","","GATD1","ENSG00000177225","","","",914.7,900.1,871.1,1166.8,993.1,1689.2,0.6977994855940349,-0.5191155608850381,0.13797333093948422,0.8602048508822406,0.38652628433755853,0.41282096809848845,2609]
["Q8NBB4","Zinc finger and SCAN domain-containing protein 1 [OS=Homo sapiens]",2,1,1,1,408,45.3,8.54,0,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZSCAN1","ENSG00000152467","","","",135.2,118.3,138.3,92.7,96.9,30.2,1.7825295723384895,0.8339260113183558,0.06301126827282982,1.2005817789414786,0.27091138812124305,0.5671727384357796,1700]
["Q8NBJ9-1","SID1 transmembrane family member 2 [OS=Homo sapiens]",5,2,2,2,832,94.4,6.96,5.39,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle","transporter activity;nucleic acid binding activity;other molecular function","SIDT2","ENSG00000149577","","","",30.5,29.9,30.7,34.4,31.3,31.4,0.9382080329557156,-0.0920202416171417,0.12819782412096595,0.8921193459582089,0.37286028511744534,0.42845387266681184,2513]
["Q8NBP0-1","Tetratricopeptide repeat protein 13 [OS=Homo sapiens]",12,8,11,8,860,96.8,7.01,35.48,"","","","TTC13","ENSG00000143643","","","",776.6,805.3,776.4,740.2,713.4,785.3,1.053329760150074,0.07495716367250804,0.1595916551816276,0.7969898210261395,0.4118839716534308,0.38522510815989797,2832]
["Q8NBS9-1","Thioredoxin domain-containing protein 5 [OS=Homo sapiens]",71,29,1001,28,432,47.6,5.97,2951.38,"transport;other biological processes","non-structural extracellular;ER/Golgi;other cytoplasmic organelle","other molecular function","TXNDC5","ENSG00000239264","Protein processing in endoplasmic reticulum","Golgi Associated Vesicle Biogenesis; Neutrophil degranulation; Lysosome Vesicle Biogenesis","VEGFA-VEGFR2 signaling pathway",105365.6,103257.7,101381.5,111578.6,111130.9,143654.6,0.8461658770605527,-0.24098758691482594,0.15778096161583743,0.801945401405461,0.40981558224952236,0.38741153262021494,2814]
["Q8NC51-3","Isoform 3 of Plasminogen activator inhibitor 1 RNA-binding protein [OS=Homo sapiens]",46,20,124,3,393,43.1,8.44,368.7,"","","","SERBP1","","","","",12701.9,12289.8,17349.3,15624.2,14111.3,10340.7,1.0565123439847093,0.07930962340299003,0.7549383463522736,0.12208851450633489,0.8323796007676524,0.0796785716398922,6629]
["Q8NC56-1","LEM domain-containing protein 2 [OS=Homo sapiens]",29,15,39,15,503,56.9,9,105.47,"cell organization and biogenesis;developmental processes;other biological processes","other membranes;nucleus","nucleic acid binding activity","LEMD2","ENSG00000161904","","Sealing of the nuclear envelope (NE) by ESCRT-III; Initiation of Nuclear Envelope (NE) Reformation; Depolymerisation of the Nuclear Lamina","",3024.7,3191.1,3088.7,2833.9,2963.2,4367.1,0.9154188229275299,-0.12749613781331584,0.5924714754556482,0.22733255392615803,0.7114135065065438,0.14787789379519353,6087]
["Q8NCG7","Sn1-specific diacylglycerol lipase beta [OS=Homo sapiens]",17,8,18,8,672,73.7,6.55,51.15,"cell-cell signaling;cell cycle OR cell proliferation;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;nucleus","other molecular function","DAGLB","ENSG00000164535","Retrograde endocannabinoid signaling; Aldosterone synthesis and secretion","Arachidonate production from DAG","Cannabinoid receptor signaling",1417.2,1405.1,1402.6,1325.2,1254.2,1799.3,0.9648754196451002,-0.05158541474785041,0.7794561917696645,0.10820828869494979,0.8496711865241577,0.07074910899859457,6705]
["Q8NCL4","Polypeptide N-acetylgalactosaminyltransferase 6 [OS=Homo sapiens]",4,3,4,2,622,71.1,8.18,13.51,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","GALNT6","ENSG00000139629","Mucin type O-glycan biosynthesis; Other types of O-glycan biosynthesis; Metabolic pathways","O-linked glycosylation of mucins","",152.3,171.8,141.7,194.7,174.3,162.2,0.8768825301204819,-0.1895445071360587,0.16751949453336043,0.7759346460860993,0.4200343003582612,0.37671524329715916,2915]
["Q8ND24","Ring finger protein 214 [OS=Homo sapiens]",8,5,7,5,703,77.6,6.95,19.94,"protein metabolism;other metabolic processes","","other molecular function","RNF214","ENSG00000167257","","","",589.1,592.6,626,746.3,744.3,635.3,0.8503222164730234,-0.23391846302429722,0.051152810344395575,1.291130501081148,0.2479283095538377,0.6056738807309303,1508]
["Q8NDA8-1","Maestro heat-like repeat-containing protein family member 1 [OS=Homo sapiens]",8,15,27,15,1641,181.1,6.89,49.58,"","","","MROH1","ENSG00000179832","","","",2421.8,2380,2419.3,2340.3,2354.7,2622.5,0.9868261018107277,-0.019132219080221596,0.7464709205301591,0.1269871059553974,0.8265347611202747,0.0827388768230096,6601]
["Q8NDX6","Zinc finger protein 740 [OS=Homo sapiens]",4,1,2,1,193,21.8,9.19,3.54,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF740","ENSG00000139651","","Generic Transcription Pathway","",91.9,95.6,83.7,99,93.1,330.9,0.518546845124283,-0.9474537679979599,0.3445535465026378,0.46274327551681893,0.5516630605449682,0.25832609550316377,4565]
["Q8NE01","Metal transporter CNNM3 [OS=Homo sapiens]",13,8,8,8,707,76.1,6.09,19.59,"transport","plasma membrane;other membranes;other cell component","transporter activity","CNNM3","ENSG00000168763","","","",536.4,508.9,552.4,543.6,521.7,654.3,0.9291114212607582,-0.10607647646954824,0.39779473196569454,0.4003409725775424,0.576423809662423,0.23925808859461342,5044]
["Q8NEL9-1","Phospholipase DDHD1 [OS=Homo sapiens]",7,5,6,5,900,100.4,5.67,14.26,"other metabolic processes;other biological processes","cytosol;other cell component","other molecular function","DDHD1","ENSG00000100523","","Synthesis of PA","",540.6,542,523.5,548.3,555.8,599.5,0.942768255459028,-0.08502491337063149,0.12908244722495843,0.8891328095663926,0.3740934206055595,0.42701992991948257,2522]
["Q8NEM2","SHC SH2 domain-binding protein 1 [OS=Homo sapiens]",28,14,44,14,672,75.6,4.75,139.46,"signal transduction;other biological processes","cytoskeleton;other cell component","","SHCBP1","ENSG00000171241","","","",2639.6,2608.3,2713.6,3476.2,3515.3,3259.1,0.7766862427565215,-0.3645961827877398,0.000874934006559886,3.058024703169394,0.03365732975761162,1.47292034223825,190]
["Q8NEZ2","Vacuolar protein sorting-associated protein 37A [OS=Homo sapiens]",7,2,2,2,397,44.3,5.57,7.15,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","","VPS37A","ENSG00000155975","Endocytosis","Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; HCMV Late Events","7q11.23 copy number variation syndrome",319.1,334,335.9,376.4,363.8,420.9,0.8517784859185257,-0.23144980389395647,0.033966206352916146,1.468952956279764,0.20517272911856538,0.6878803647122412,1210]
["Q8NF37","Lysophosphatidylcholine acyltransferase 1 [OS=Homo sapiens]",32,12,41,12,534,59.1,6.02,121.9,"other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","LPCAT1","ENSG00000153395","Glycerophospholipid metabolism; Ether lipid metabolism; Metabolic pathways","Neutrophil degranulation; Synthesis of PA; Acyl chain remodelling of PC; Acyl chain remodelling of PG; Synthesis of PC","",3991,3991.4,4039.3,4152.9,4147,5165.7,0.8927712096007606,-0.16363759150602644,0.22865660937881285,0.640816240706821,0.47250527507767687,0.32559333863759965,3537]
["Q8NFG4-1","Folliculin [OS=Homo sapiens]",7,3,3,3,579,64.4,6.23,7.92,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","FLCN","ENSG00000154803","mTOR signaling pathway; Renal cell carcinoma","Amino acids regulate mTORC1","Ciliopathies",318.8,314.3,323.8,364.2,320.1,150.7,1.145988023952096,0.19659196741488755,0.5665321455775343,0.24677544281583022,0.6951122128632193,0.157945081030702,5957]
["Q8NFT6-1","Protein DBF4 homolog B [OS=Homo sapiens]",1,1,1,1,615,67.2,8.34,0,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","DBF4B","ENSG00000161692","","","",639.5,603.6,592.6,610.3,596.5,1108,0.7930274753758424,-0.3345572442143463,0.3977805960371423,0.4003564058257878,0.5765176237230761,0.23918741210094824,5043]
["Q8NG11-1","Tetraspanin-14 [OS=Homo sapiens]",8,2,2,2,270,30.7,6.84,5.39,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","TSPAN14","ENSCATG00000031568; ENSCSAG00000009464; ENSG00000108219; ENSGGOG00000005770; ENSMMUG00000013895; ENSMNEG00000032257; ENSNLEG00000029109; ENSPPAG00000030989; ENSPTRG00000002686","","Neutrophil degranulation; Amyloid fiber formation","",108.5,99.6,116,140.5,135.4,230.6,0.6398815399802567,-0.64412324837066,0.12384175947565816,0.9071328864000296,0.3684002523433396,0.43368008099613764,2457]
["Q8NH93","Olfactory receptor 1L3 [OS=Homo sapiens]",2,1,1,1,324,36.6,9.2,2.06,"signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","OR1L3","ENSG00000171481","Olfactory transduction","","",49.4,47.7,43.9,60.4,44.1,17.7,1.1538461538461537,0.20645087746742624,0.643671393134051,0.19133579191204272,0.7498556283737294,0.125022344389796,6274]
["Q8NHU6","tudor domain-containing protein 7 [OS=Homo sapiens]",4,5,5,5,1098,123.5,7.21,9.53,"developmental processes;other biological processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","TDRD7","ENSG00000196116","","","",649.4,636.6,690.4,693,675.6,463.3,1.0788798515202795,0.10953420934187218,0.5586810105530207,0.2528360899646843,0.6891813512459118,0.1616664827628529,5925]
["Q8NHV4","Protein NEDD1 [OS=Homo sapiens]",13,8,15,8,660,71.9,7.97,41.05,"cell cycle OR cell proliferation;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus","","NEDD1","ENSG00000139350","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",1499,1462.7,1468.2,1555.1,1610.2,1315,0.9887507532977701,-0.01632120615802067,0.8629949114793036,0.0639917650298364,0.9078338814050417,0.04199361292092448,6948]
["Q8NI60-1","Atypical kinase COQ8A, mitochondrial [OS=Homo sapiens]",9,6,15,6,647,71.9,6.99,44.09,"protein metabolism;other metabolic processes","other membranes;mitochondrion","kinase activity;other molecular function","COQ8A","ENSG00000163050","","","",1861.4,1743.9,1753.8,1892.7,1876.7,1911.7,0.9433208357536393,-0.0841795610728504,0.05111891343211013,1.2914183859813841,0.24809305330364737,0.605385395962093,1506]
["Q8TAF3-1","WD repeat-containing protein 48 [OS=Homo sapiens]",22,11,23,11,677,76.2,7.03,55.85,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","WDR48","ENSANAG00000001805; ENSCAFG00000005066; ENSCANG00000036746; ENSCATG00000045029; ENSCCAG00000035592; ENSCSAG00000014688; ENSFCAG00000025123; ENSG00000114742; ENSGGOG00000002185; ENSLCNG00005009903; ENSMLEG00000040913; ENSMMUG00000020138; ENSMNEG00000033674; ENSNLEG00000005481; ENSPANG00000006231; ENSPPAG00000029758; ENSPTRG00000014765; ENSRROG00000029632; ENSSSCG00070011863; ENSSTOG00000011459","Fanconi anemia pathway","Fanconi Anemia Pathway; Ub-specific processing proteases; Recognition of DNA damage by PCNA-containing replication complex; Ub-specific processing proteases; Fanconi Anemia Pathway; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins; Recognition of DNA damage by PCNA-containing replication complex","DNA repair pathways, full network",1981.2,1973.8,1966.5,2458.9,2422.6,3523.8,0.7044959727790799,-0.5053366354330131,0.0836527927319473,1.0775195556241421,0.3129059683100321,0.5045861531229234,1954]
["Q8TAQ2","SWI/SNF complex subunit SMARCC2 [OS=Homo sapiens]",38,52,186,1,1214,132.8,5.69,556.76,"cell organization and biogenesis;developmental processes;other biological processes","nucleus","other molecular function","SMARCC2","ENSG00000139613","Thermogenesis; Hepatocellular carcinoma","RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","Tumor suppressor activity of SMARCB1; Thermogenesis",22156.4,22074.9,22106.3,24004,25466.4,19261.1,0.9651702639983124,-0.051144626746688224,0.6920135515051977,0.15988540079424945,0.785636385205264,0.10477841125987125,6438]
["Q8TB36","ganglioside-induced differentiation-associated protein 1 [OS=Homo sapiens]",10,3,4,3,358,41.3,8.34,12.93,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;mitochondrion;other cytoplasmic organelle","","GDAP1","ENSG00000104381","","Class I peroxisomal membrane protein import","Intracellular trafficking proteins involved in CMT neuropathy",136.2,136.4,127.6,126.8,114.8,241.2,0.8289146644573324,-0.27070450884928,0.5328317945277246,0.27340986834232717,0.6711128013446732,0.17320447702288463,5803]
["Q8TBQ9","Protein kish-A [OS=Homo sapiens]",13,1,11,1,72,8.1,8.95,25.22,"transport","other membranes;ER/Golgi","","TMEM167A","ENSG00000174695","","","",1426.9,1524.7,1436.9,1177.1,1177.3,359.7,1.6169264212814562,0.6932540300375779,0.11157458677964452,0.9524347129091449,0.3531826135870168,0.45200068394234827,2309]
["Q8TBZ6","tRNA methyltransferase 10 homolog A [OS=Homo sapiens]",8,3,3,3,339,39.7,7.65,5.15,"RNA metabolism OR transcription;other metabolic processes","cytosol;cytoskeleton;mitochondrion;nucleus","nucleic acid binding activity;other molecular function","TRMT10A","ENSG00000145331","","tRNA modification in the nucleus and cytosol","",318.7,316.8,307.5,354.6,400.9,129.6,1.0654163371370464,0.09141730852520719,0.8292714120327257,0.0813033060519471,0.8854849891230376,0.05281879663798291,6845]
["Q8TCG2","Phosphatidylinositol 4-kinase type 2-beta [OS=Homo sapiens]",11,6,9,5,481,54.7,5.97,19.27,"cell organization and biogenesis;other metabolic processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","kinase activity;other molecular function","PI4K2B","ENSG00000038210","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the ER membrane","",548.8,549.2,532.8,622.5,657.6,1155.8,0.6694856110677779,-0.5788750461551607,0.1943337116427099,0.7114518545188914,0.44179940852148264,0.3547748698951593,3215]
["Q8TCJ2","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [OS=Homo sapiens]",19,19,81,18,826,93.6,8.91,215.66,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi;other cell component","other molecular function","STT3B","ENSG00000163527","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum","","",10508,11162.4,10994.4,9802.7,10199.8,7285.3,1.197047764935246,0.2594807202516336,0.1272402606943954,0.8953754497657006,0.3714053775620351,0.43015181242011974,2504]
["Q8TD16","Protein bicaudal D homolog 2 [OS=Homo sapiens]",42,30,63,27,824,93.5,5.44,201,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","BICD2","ENSG00000185963","","COPI-independent Golgi-to-ER retrograde traffic","",5384.6,5404.9,5334.2,6466.3,6359.7,6190,0.8479017669331089,-0.23803096284369288,3.1615524006564253E-4,3.5000996156450572,0.02081782567243046,1.6815646325477416,111]
["Q8TDB6-1","E3 ubiquitin-protein ligase DTX3L [OS=Homo sapiens]",1,1,1,1,740,83.5,8.06,2.45,"protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","DTX3L","ENSG00000163840","Notch signaling pathway","Antigen processing: Ubiquitination & Proteasome degradation","Notch signaling",64.6,64.1,55.9,128.3,117.4,140.9,0.4774961200206932,-1.0664390845654617,7.89144190389372E-4,3.1028436363734477,0.033148591307792644,1.4795349227720742,174]
["Q8TDI8","Transmembrane channel-like protein 1 [OS=Homo sapiens]",1,1,2,1,760,87.7,6.52,3.9,"transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","transporter activity","TMC1","ENSG00000165091","","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea","",463.9,383.6,440.6,314.8,302.2,73.1,{"$f":"AVERAGE(S4674:U4674)/AVERAGE(V4674:X4674)","v":1.866541081002753},{"$f":"LOG(Y4674,2)","v":0.9003672614975214},{"$f":"TTEST(S4674:U4674,V4674:X4674,2,2)","v":0.07212392084407171},{"$f":"-LOG10(AA4674)","v":1.1419206719293977},{"$f":"AA4674*7309/AE4674","v":0.29253814508841297},{"$f":"-LOG10(AC4674)","v":0.5338174966884689},1802]
["Q8TDY2-1","RB1-inducible coiled-coil protein 1 [OS=Homo sapiens]",17,26,40,26,1594,183,5.41,90.54,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RB1CC1","ENSG00000023287","Autophagy; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration","Macroautophagy","Alzheimer's disease and miRNA effects; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Malignant pleural mesothelioma; Alzheimer's disease; Senescence and autophagy in cancer",3522.5,3477.7,3464.4,3691.5,3444.4,4135.3,0.9284370785719356,-0.10712395479471692,0.25572641563795884,0.5922244085662969,0.4947338199835472,0.30562840026813864,3778]
["Q8TEA8","D-aminoacyl-tRNA deacylase 1 [OS=Homo sapiens]",35,6,23,6,209,23.4,8.24,66.76,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DTD1","ENSG00000125821","","","",2462,2453.3,2477.5,2712.2,2318.4,1590.5,1.1165516303937413,0.1590499642735175,0.4775308839348279,0.3209985355174344,0.631495066162413,0.19963003821523662,5527]
["Q8TED0","U3 small nucleolar RNA-associated protein 15 homolog [OS=Homo sapiens]",21,12,22,12,518,58.4,9.11,54.87,"RNA metabolism OR transcription;other metabolic processes;other biological processes","ER/Golgi;nucleus;other cell component","","UTP15","ENSG00000164338","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",2726.8,2648,2665.3,3149.9,3011.4,4193.2,0.7764836544497561,-0.3649725397435318,0.10795632988885534,0.9667518882514163,0.34653175896251365,0.46025695698258623,2277]
["Q8TET4","neutral alpha-glucosidase c [OS=Homo sapiens]",5,2,2,2,914,104.3,6.23,6.3,"protein metabolism;other metabolic processes","","other molecular function","GANC","ENSG00000214013","Galactose metabolism; Starch and sucrose metabolism; Metabolic pathways","","",40.7,45.9,39.1,50.7,42,50.9,0.8753481894150418,-0.19207109940254358,0.1709701937480239,0.7670795961520355,0.42216930611631986,0.37451334532700115,2960]
["Q8TEU7","Rap guanine nucleotide exchange factor 6 [OS=Homo sapiens]",12,16,23,14,1601,179.3,6.4,67.06,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","RAPGEF6","ENSG00000158987","Rap1 signaling pathway; Tight junction","","",1449.7,1445.2,1463.9,1735.6,1729.3,4314.7,0.560285875880508,-0.8357649704327391,0.2558818169886307,0.5919605740661902,0.4943801745624906,0.30593895347496125,3783]
["Q8TF30","WASP homolog-associated protein with actin, membranes and microtubules [OS=Homo sapiens]",3,2,3,2,809,90.9,7.08,12.4,"cell adhesion;cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","WHAMM","ENSG00000156232","Tight junction","RHOD GTPase cycle","",154.1,159.5,156.4,128,130.1,230.8,0.9613417876866435,-0.05687864855577525,0.8618469113163068,0.06456987045729477,0.9072791408340611,0.04225907382987509,6943]
["Q8WTS6","Histone-lysine N-methyltransferase SETD7 [OS=Homo sapiens]",34,10,22,10,366,40.7,4.63,70.13,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","other molecular function","SETD7","ENSG00000145391","Lysine degradation; Metabolic pathways; FoxO signaling pathway","PKMTs methylate histone lysines","Histone modifications",2148.8,2212.3,2163,2499.9,2585,2431.2,0.8680166575750724,-0.20420536607664122,0.002412972437008165,2.617447638938138,0.056526972891322684,1.2477442710726077,312]
["Q8WTW4","GATOR complex protein NPRL2 [OS=Homo sapiens]",10,3,4,3,380,43.6,6.52,11.64,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;other cytoplasmic organelle;other cell component","enzyme regulator activity;kinase activity","NPRL2","ENSG00000114388","mTOR signaling pathway","Amino acids regulate mTORC1","22q11.2 copy number variation syndrome",301.5,274.3,281.1,327.7,343.9,245.6,0.9342564326210206,-0.09810950288182682,0.558190425878623,0.25321761683295196,0.6886924076210087,0.16197470479814988,5924]
["Q8WUA4-1","General transcription factor 3C polypeptide 2 [OS=Homo sapiens]",14,9,12,9,911,100.6,7.31,32.67,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","GTF3C2","ENSG00000115207; ENSPPAG00000042866; ENSPTRG00000011763","","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter","",1418.7,1393.2,1470.7,1673.2,1636.9,2452.1,0.7432230745201486,-0.42813280175261226,0.13829068711727746,0.8592070655143993,0.3871185875680509,0.41215597545337074,2611]
["Q8WUF8","Protein Fam172a [OS=Homo sapiens]",11,4,5,4,416,47.9,6.09,13.07,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","ER/Golgi;nucleus","","FAM172A","ENSG00000113391","","","",213.7,219.1,211.7,233.4,226.8,204.9,0.969027213952789,-0.04539091233945006,0.48308792201995726,0.315973820442804,0.6336844260667387,0.19812696631075685,5572]
["Q8WUM0","Nuclear pore complex protein Nup133 [OS=Homo sapiens]",39,35,105,35,1156,128.9,5.1,328.44,"cell organization and biogenesis;other metabolic processes;transport;developmental processes","other membranes;cytosol;nucleus;other cell component","other molecular function","NUP133","ENSG00000069248","Nucleocytoplasmic transport; Amyotrophic lateral sclerosis","Separation of Sister Chromatids; Transport of Mature mRNA derived from an Intron-Containing Transcript; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; ISG15 antiviral mechanism; Transcriptional regulation by small RNAs; tRNA processing in the nucleus; Viral Messenger RNA Synthesis; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; HCMV Early Events; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Postmitotic nuclear pore complex (NPC) reformation","Ciliary landscape",9564.3,9455.6,9618.2,8540,8584.7,5453.8,1.268379210310694,0.3429861358912965,0.12336576947016933,0.9088053280863572,0.36818309883930894,0.4339361513270983,2449]
["Q8WUX1-1","Sodium-coupled neutral amino acid transporter 5 [OS=Homo sapiens]",10,5,11,5,472,51.4,8.21,26.74,"transport","plasma membrane;other membranes","transporter activity","SLC38A5","ENSG00000017483","GABAergic synapse","Amino acid transport across the plasma membrane","Neuroinflammation and glutamatergic signaling",1302.5,1290.4,1350.3,1629.2,1621.1,1907.1,0.7645712956140691,-0.38727705695987796,0.013413990292218656,1.8724420122966492,0.1326696279375185,0.8772284888075018,739]
["Q8WUY1","Protein THEM6 [OS=Homo sapiens]",26,5,8,5,208,23.9,9.55,20.98,"","non-structural extracellular","","THEM6","ENSG00000130193","","","",974.3,1017.9,1061.4,875.1,1031.3,2520.2,0.6898296661094293,-0.535687921686371,0.43244827793332624,0.3640658279711716,0.5987430315239025,0.2227595280881571,5279]
["Q8WVB3","Hexosaminidase D [OS=Homo sapiens]",14,4,7,4,486,53.8,5.97,9.2,"other metabolic processes","non-structural extracellular;nucleus;other cell component","other molecular function","HEXD","ENSG00000169660","Other glycan degradation; Various types of N-glycan biosynthesis; Metabolic pathways","","",468.8,418,470.4,439.9,476.2,855.8,0.7659574468085105,-0.38466385023532523,0.3608876461178834,0.44262798442612117,0.5573056846557384,0.25390652701014216,4733]
["Q8WVM0","Dimethyladenosine transferase 1, mitochondrial [OS=Homo sapiens]",10,3,5,3,346,39.5,9.26,9.47,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","nucleic acid binding activity;other molecular function","TFB1M","ENSG00000029639","","Transcriptional activation of mitochondrial biogenesis; rRNA modification in the mitochondrion","Energy metabolism; Mitochondrial gene expression",591,606.1,584,600.9,629.5,1067.6,0.7750652741514359,-0.3676102790436514,0.31798713359365766,0.49759045209834074,0.5368833355130617,0.2701200760275244,4329]
["Q8WVP7-1","Limb region 1 protein homolog [OS=Homo sapiens]",4,2,3,2,490,55.1,5.94,7.03,"developmental processes;signal transduction","plasma membrane;other membranes","other molecular function","LMBR1","ENSG00000105983; ENSPPYG00000018221","","","",161.5,157.9,161,154.2,152.3,625.6,0.5153953438472267,-0.9562485911373627,0.39309612794726023,0.40550123402122484,0.5742833498234109,0.2408737750206611,5003]
["Q8WW59","SPRY domain-containing protein 4 [OS=Homo sapiens]",27,4,9,4,207,23.1,6.93,24.78,"","nucleus","","SPRYD4","ENSG00000176422","","","",775.6,761,747.7,718.1,629.7,508.7,1.2304336116347967,0.2991668189101947,0.08032907340990784,1.0951272425633587,0.30787897092449734,0.5116199737253914,1907]
["Q8WWM7-1","ataxin-2-like protein [OS=Homo sapiens]",32,28,81,27,1075,113.3,8.59,230.61,"cell organization and biogenesis;other biological processes","other membranes;cytosol;nucleus;other cell component","","ATXN2L","ENSG00000168488","Amyotrophic lateral sclerosis; Spinocerebellar ataxia; Pathways of neurodegeneration","","16p11.2 distal deletion syndrome",9517.7,9688.1,10398.5,14436.5,13757.8,15680.9,0.6747388046094377,-0.5675989604585759,1.5932567335755917E-3,2.797714237386905,0.044788897945015387,1.34882962347375,260]
["Q8WWW0-2","Isoform 2 of Ras association domain-containing protein 5 [OS=Homo sapiens]",20,5,16,5,265,30.3,8.09,42.51,"","","","RASSF5","","","","",1599,1622.2,1542.9,1937.3,2150.7,1407,0.8669881710646042,-0.2059157850190901,0.33472373156800195,0.4753134955189429,0.5447552335850648,0.26379858869768474,4491]
["Q8WXB1-1","Protein N-lysine methyltransferase METTL21A [OS=Homo sapiens]",4,1,1,1,218,24.6,6.27,2.67,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","METTL21A","ENSG00000144401","","Protein methylation","",69,80.3,59.7,62.5,73.6,98.9,0.8893617021276596,-0.16915781448411688,0.5201755554072375,0.28385006044692707,0.660981073447757,0.1798109759377803,5752]
["Q8WXE9-1","Stonin-2 [OS=Homo sapiens]",7,4,6,4,905,101.1,5.39,16.32,"transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","STON2","ENSG00000140022","","Cargo recognition for clathrin-mediated endocytosis","",428.6,377.6,434.2,504.1,466.4,581.2,0.79938132370948,-0.32304422804152105,0.05350896002792267,1.2715734896634492,0.25183321883070625,0.5988869835080348,1553]
["Q8WXX7-1","Autism susceptibility gene 2 protein [OS=Homo sapiens]",1,1,1,1,1259,138.9,9.38,2.35,"cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","AUTS2","ENSG00000158321","","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","",59.9,57.6,59.8,83.8,76.7,669.2,0.21369169579366037,-2.2263972499223277,0.3301262683905358,0.4813199171626723,0.5411287050160185,0.2666994276283066,4459]
["Q8WYP5","protein elys [OS=Homo sapiens]",23,37,83,37,2266,252.3,6.6,286.37,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity","AHCTF1","ENSG00000153207","Nucleocytoplasmic transport","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation","Gastric cancer network 2",7094.7,6847.1,6864.5,7453.9,7415.2,9060.2,0.8694905408850238,-0.2017577622289874,0.13021052149007373,0.8853539217550599,0.3755756517643839,0.42530257041850955,2534]
["Q8WZ42","Titin [OS=Homo sapiens]",0,7,16,3,34350,3813.7,6.35,25.83,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus","cytoskeletal activity;kinase activity;other molecular function","TTN","ENSG00000155657","Hypertrophic cardiomyopathy; Dilated cardiomyopathy","Platelet degranulation ; Striated Muscle Contraction","Striated muscle contraction pathway",1577.2,1633.4,1569.4,1534.8,1489.4,794.2,1.2518332285774145,0.32404237670326924,0.2534623710980127,0.5960865066955277,0.4937517245083621,0.3064913745185816,3752]
["Q92187-1","CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase [OS=Homo sapiens]",7,2,2,2,359,41.3,9.74,6.59,"protein metabolism;other metabolic processes;developmental processes","other membranes;ER/Golgi","other molecular function","ST8SIA4","ENSANAG00000034757; ENSCCAG00000025138; ENSG00000113532; ENSGGOG00000011260; ENSNLEG00000035472; ENSPPAG00000033695; ENSPPYG00000015661; ENSPTRG00000042921","","Sialic acid metabolism; NCAM1 interactions","Ectoderm differentiation",65.4,68.5,66.8,91.3,96.3,431.4,0.324232633279483,-1.6248987927390104,0.2831133330962076,0.548039677248259,0.5160287659850827,0.28732608798446824,4010]
["Q92508","Piezo-type mechanosensitive ion channel component 1 [OS=Homo sapiens]",11,19,33,19,2521,286.6,7.47,120.25,"transport;other biological processes","plasma membrane;other membranes;ER/Golgi","transporter activity","PIEZO1","ENSG00000103335","","","",1937.9,2063.3,2060.3,1730.6,1839.7,2975.8,0.9259711889522005,-0.11096078930943194,0.7071769234954078,0.1504719196043194,0.7966640156948113,0.0987247989234461,6488]
["Q92522","Histone H1x [OS=Homo sapiens]",54,15,108,15,213,22.5,10.76,339.77,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity","H1-10","ENSG00000184897","","","",18396.2,20226.4,20256.4,11792.9,12834.8,16936.8,1.4165694282380399,0.5024013121431825,0.026714818969685278,1.5732477644244824,0.18596058271374255,0.7305791016104475,1050]
["Q92544","Transmembrane 9 superfamily member 4 [OS=Homo sapiens]",20,12,30,12,642,74.5,6.54,95.66,"cell adhesion;cell organization and biogenesis;stress response;transport;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","","TM9SF4","ENSG00000101337","","","",2868.6,2772.3,2858,2820.1,2629.9,2889.2,1.019150518035303,0.02736713843873905,0.5575735968495158,0.2536977998563382,0.688279922204545,0.16223489905436544,5921]
["Q92551","Inositol hexakisphosphate kinase 1 [OS=Homo sapiens]",7,2,2,2,441,50.2,7.24,4.45,"other metabolic processes;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","IP6K1","ENSG00000176095","Phosphatidylinositol signaling system","Synthesis of pyrophosphates in the cytosol; Synthesis of IPs in the nucleus","",265.7,247.2,241.4,253.9,290.2,124.1,1.1288536366357376,0.1748584432515727,0.6032922466915434,0.21947225605391935,0.7188560533205887,0.14335806581641303,6134]
["Q92576-1","PHD finger protein 3 [OS=Homo sapiens]",11,13,21,13,2039,229.3,6.96,77.84,"RNA metabolism OR transcription;other metabolic processes;developmental processes","","other molecular function","PHF3","ENSG00000118482","","","",1383.9,1348.1,1360.9,2066.4,2126.5,3624.3,0.5235762165481247,-0.9335285305442036,0.07154093795796458,1.1454453702074865,0.29130513400265357,0.5356518612378514,1795]
["Q92609-1","TBC1 domain family member 5 [OS=Homo sapiens]",28,15,26,15,795,88.9,6.54,79.85,"other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","TBC1D5","ENSG00000131374","","","",855.9,817.4,860.3,890.1,890.9,900.7,0.9447738374911436,-0.08195908045329423,0.024566837641617253,1.609650744341512,0.17884364175555828,0.7475264952665396,1004]
["Q92613","protein jade-3 [OS=Homo sapiens]",5,4,4,4,823,93.7,7.18,7.19,"protein metabolism;other metabolic processes","nucleus","other molecular function","JADE3","ENSG00000102221","","HATs acetylate histones","",190,195.9,191.7,216.1,211.7,575.8,0.575528098844161,-0.7970417285220017,0.3044751832524379,0.5164480994703282,0.5284752112068556,0.2769753790066203,4211]
["Q92622-1","Run domain Beclin-1-interacting and cysteine-rich domain-containing protein [OS=Homo sapiens]",7,5,8,5,972,108.6,6.25,16.64,"other metabolic processes;transport;other biological processes","cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RUBCN","ENSG00000145016","Autophagy","","",791.2,750.5,753.2,813,733.9,1170,0.844675917405867,-0.24353017601849478,0.35556663325135696,0.44907900044287735,0.5561387807477355,0.25481681958321767,4673]
["Q92696","geranylgeranyl transferase type-2 subunit alpha [OS=Homo sapiens]",30,14,42,14,567,65,5.67,113.42,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","RABGGTA","ENSG00000100949; ENSG00000285193","","RAB geranylgeranylation; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain","",4145.3,4037.2,4043.4,4336.4,4057.9,6456.2,0.8232652099255916,-0.28057083385292886,0.31275049922358195,0.5048019883975358,0.5337131447175253,0.2726921009101321,4283]
["Q92747","Actin-related protein 2/3 complex subunit 1A [OS=Homo sapiens]",19,6,19,5,370,41.5,8.18,61.41,"cell organization and biogenesis","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity","ARPC1A","ENSG00000241685","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection","Clathrin-mediated endocytosis; FCGR3A-mediated phagocytosis; EPHB-mediated forward signaling; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs","Pathogenic Escherichia coli infection",2328.3,2413.8,2502.7,2208.8,2134.5,2058.3,1.131717070732317,0.17851332948628051,0.013408428448505849,1.8726221211892624,0.1327943137264624,0.876820521128331,738]
["Q92793-1","CREB-binding protein [OS=Homo sapiens]",8,15,27,8,2442,265.2,8.53,70.88,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CREBBP","ENSG00000005339","cAMP signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Cell cycle; Wnt signaling pathway; Notch signaling pathway; TGF-beta signaling pathway; Adherens junction; JAK-STAT signaling pathway; Long-term potentiation; Melanogenesis; Thyroid hormone signaling pathway; Glucagon signaling pathway; Growth hormone synthesis, secretion and action; Huntington disease; Tuberculosis; Hepatitis B; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Pathways in cancer; Viral carcinogenesis; MicroRNAs in cancer; Renal cell carcinoma; Prostate cancer","Heme signaling; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RORA activates gene expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; HATs acetylate histones; SUMOylation of transcription cofactors; Pre-NOTCH Transcription and Translation; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production; Formation of the beta-catenin:TCF transactivating complex; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation; Attenuation phase; CD209 (DC-SIGN) signaling; Activation of the TFAP2 (AP-2) family of transcription factors; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Regulation of gene expression by Hypoxia-inducible Factor; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells","Androgen receptor signaling pathway; Angiogenesis; TNF-alpha signaling pathway; Notch signaling; Initiation of transcription and translation elongation at the HIV-1 LTR; IL-6 signaling pathway; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Wnt signaling pathway and pluripotency; Clear cell renal cell carcinoma pathways; Ebola virus pathway in host; Type 2 papillary renal cell carcinoma; Ciliary landscape; Hepatitis B infection; Male infertility; TGF-beta receptor signaling in skeletal dysplasias; Overlap between signal transduction pathways contributing to LMNA laminopathies; 15q13.3 copy number variation syndrome; TGF-beta receptor signaling; Sudden infant death syndrome (SIDS) susceptibility pathways",1999.1,1849.7,1947.6,2357.5,2433.6,1857.4,0.8718357524253592,-0.19787172763826877,0.20137677021079614,0.6959906288724077,0.4480556509804289,0.34866804088423436,3285]
["Q92797-1","Symplekin [OS=Homo sapiens]",28,34,94,34,1274,141.1,6.13,244.46,"cell adhesion;RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","","SYMPK","ENSG00000125755","mRNA surveillance pathway; Tight junction","mRNA Splicing - Major Pathway; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs","",11017.2,10954.3,11104.7,12437.5,12592.7,13783.1,0.8521872657053122,-0.2307576015043672,0.01102518976090425,1.9576139269028112,0.1200940565759302,0.9204784851878304,671]
["Q92845","Kinesin-associated protein 3 [OS=Homo sapiens]",10,7,10,6,792,91.1,5.08,27.94,"cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","KIFAP3","ENSG00000075945","","COPI-dependent Golgi-to-ER retrograde traffic; Translocation of SLC2A4 (GLUT4) to the plasma membrane; MHC class II antigen presentation; Kinesins; Intraflagellar transport","Genes related to primary cilium development (based on CRISPR)",349.2,293.6,336.2,388.8,370.6,430.5,0.8227582149760483,-0.2814595686200376,0.04506320148572858,1.3461779573482053,0.23129700818763355,0.63582998476507,1424]
["Q92882","osteoclast-stimulating factor 1 [OS=Homo sapiens]",37,5,15,5,214,23.8,5.68,53.68,"signal transduction;other biological processes","other cell component","other molecular function","OSTF1","ENSG00000134996","","Neutrophil degranulation","",1255.1,1281.2,1255.7,1365.7,1370.2,1973.4,0.8052152124519568,-0.3125536663915456,0.20466888737895453,0.6889481713413925,0.4516681454869501,0.345180537570262,3312]
["Q92890-1","Isoform Long of Ubiquitin recognition factor in ER-associated degradation protein 1 [OS=Homo sapiens]",37,13,34,13,343,38.7,6.34,102.54,"","","","UFD1","","","","",4558.2,4573.6,4667.2,4680.2,4671.1,5170.7,0.9502134692191159,-0.07367643787771423,0.22590587237412763,0.6460724795420927,0.469475695530992,0.3283868859750623,3517]
["Q92918","mitogen-activated protein kinase kinase kinase kinase 1 [OS=Homo sapiens]",23,14,25,14,833,91.2,8.34,62.26,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes","","kinase activity;other molecular function","MAP4K1","ENSG00000104814; ENSG00000282928","MAPK signaling pathway","","B cell receptor signaling pathway; Cardiac hypertrophic response; Hepatocyte growth factor receptor signaling; TGF-beta signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; EGF/EGFR signaling pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Insulin signaling; Modulators of TCR signaling and T cell activation; Malignant pleural mesothelioma; T-cell receptor (TCR) signaling pathway",1589.4,1650,1607.7,1601.1,1634,2020.1,0.9223435834982494,-0.11662382376289213,0.3728815614249727,0.42842909148281433,0.563446626515428,0.24914721698729664,4837]
["Q92963","GTP-binding protein Rit1 [OS=Homo sapiens]",17,2,3,2,219,25.1,9.1,10.42,"signal transduction","plasma membrane;other membranes","other molecular function","RIT1","ENSG00000143622","","Signalling to p38 via RIT and RIN","Ectoderm differentiation; Ectoderm differentiation",110.2,104.8,104,111.9,101.5,135.3,0.9148264984227128,-0.128429940124473,0.3859893941319712,0.4134246283159156,0.5713237103504613,0.2431177520278561,4938]
["Q92966","snRNA-activating protein complex subunit 3 [OS=Homo sapiens]",11,2,2,2,411,46.7,5.27,3.54,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SNAPC3","ENSG00000164975","","RNA polymerase II transcribes snRNA genes; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter","",18.1,11.9,14,15.9,16.3,317.4,0.12585812356979406,-2.9901297559759388,0.36788829191148203,0.43428403342233224,0.5607707039793581,0.25121468304504163,4795]
["Q92997","segment polarity protein dishevelled homolog DVL-3 [OS=Homo sapiens]",11,6,9,4,716,78,6.65,16.05,"cell-cell signaling;developmental processes;signal transduction;other biological processes","cytosol;other cell component","signal transduction activity or receptor binding;other molecular function","DVL3","ENSG00000161202","mTOR signaling pathway; Wnt signaling pathway; Notch signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer","WNT mediated activation of DVL; Degradation of DVL; RHO GTPases Activate Formins; PCP/CE pathway; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Negative regulation of TCF-dependent signaling by DVL-interacting proteins; WNT5:FZD7-mediated leishmania damping","Alzheimer's disease and miRNA effects; Neural crest differentiation; Notch signaling; Wnt signaling pathway; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Ciliary landscape; Joubert syndrome; Malignant pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)",735.3,743.2,712,795.1,785.1,2214,0.577328554108903,-0.7925355134831759,0.3231373641879602,0.4906128218571536,0.539103171616024,0.2683281131513561,4381]
["Q93034","Cullin-5 [OS=Homo sapiens]",22,18,47,18,780,90.9,7.94,120.07,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;transport;signal transduction","cytosol;other cell component","transporter activity;other molecular function","CUL5","ENSG00000166266","Ubiquitin mediated proteolysis; Human immunodeficiency virus 1 infection","Antigen processing: Ubiquitination & Proteasome degradation; Vif-mediated degradation of APOBEC3G; Neddylation; Inactivation of CSF3 (G-CSF) signaling; Downregulation of ERBB2 signaling","Apoptosis-related network due to altered Notch3 in ovarian cancer; Dual hijack model of Vif in HIV infection; Modulators of TCR signaling and T cell activation",4725.5,4610.3,4595.7,4815.3,4629,3492.8,1.0768642122268517,0.10683634394201351,0.46952240956148805,0.32834367471493603,0.6258871587606997,0.20350395871444396,5483]
["Q93086-1","Isoform 2 of P2X purinoceptor 5 [OS=Homo sapiens]",6,2,2,2,421,47.1,7.28,7.62,"","","","P2RX5","","","","",290.6,300.2,306.3,349.1,274.4,254.6,1.0216376266939984,0.03088356527973592,0.8385458515002036,0.0764731852831849,0.8913513130620982,0.04995109141422676,6876]
["Q969F2-1","protein naked cuticle homolog 2 [OS=Homo sapiens]",3,1,1,1,451,50,7.96,4.31,"cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","NKD2","ENSG00000145506; ENSG00000276920","Wnt signaling pathway; Hippo signaling pathway","","Wnt signaling pathway and pluripotency; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma",15.8,26.2,16.5,20.4,21.2,81,0.47716150081566067,-1.0674504492200148,0.3529146124373696,0.4523303592950755,0.5547210542590827,0.2559253503010564,4650]
["Q969H4","Connector enhancer of kinase suppressor of Ras 1 [OS=Homo sapiens]",8,3,3,3,720,79.7,5.38,10.8,"signal transduction","plasma membrane;other membranes;other cell component","other molecular function","CNKSR1","ENSG00000142675","","Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants","",72.3,62.5,77.6,82.3,79.1,88.5,0.8499399759903962,-0.2345671352825502,0.07453445284289781,1.1276429323410335,0.29768979007034974,0.5262360601874901,1830]
["Q969M1","Mitochondrial import receptor subunit TOM40B [OS=Homo sapiens]",5,2,6,2,308,33.9,7.24,24.12,"cell organization and biogenesis;transport","other membranes;mitochondrion;other cell component","transporter activity;other molecular function","TOMM40L","ENSG00000158882","Amyotrophic lateral sclerosis; Pathways of neurodegeneration","","",390.1,378,366,336.9,377.6,679.3,0.8136748457454441,-0.29747570352455815,0.4685522562332668,0.32924196650901905,0.6252781524208412,0.20392674555383128,5477]
["Q969R5-1","Lethal(3)malignant brain tumor-like protein 2 [OS=Homo sapiens]",2,1,1,1,705,79.1,6.84,4.57,"cell organization and biogenesis;other biological processes","nucleus","other molecular function","L3MBTL2","ENSG00000100395","","SUMOylation of chromatin organization proteins; Transcriptional Regulation by E2F6","",89.1,77.4,92.7,135.2,130.1,288.8,0.4677855982674608,-1.0960806488189696,0.1332147602973812,0.8754476523387145,0.38004164052051487,0.420168815863409,2562]
["Q969S9","Ribosome-releasing factor 2, mitochondrial [OS=Homo sapiens]",15,12,19,11,779,86.5,6.51,52.92,"cell organization and biogenesis;protein metabolism;other metabolic processes","mitochondrion","other molecular function","GFM2","ENSG00000164347","","Mitochondrial translation termination","",2906.9,2758.7,2827,2776.4,2718.5,2843.1,1.018541616694651,0.026504928730291127,0.4091094302320453,0.38816050962277493,0.5823136953390495,0.23484299567209893,5135]
["Q969V6","MKL/myocardin-like protein 1 [OS=Homo sapiens]",2,2,3,1,931,98.9,5.86,5.08,"cell organization and biogenesis;stress response;other biological processes","cytosol;nucleus;other cell component","cytoskeletal activity;other molecular function","MRTFA","ENSG00000196588","","RHO GTPases Activate Formins; SUMOylation of transcription cofactors","",48,41.7,35.4,47.7,47.3,138.9,0.5348439504061564,-0.902810072186608,0.3026831634296562,0.519011735742979,0.5276201386852747,0.2776786362625743,4193]
["Q969X6","U3 small nucleolar RNA-associated protein 4 homolog [OS=Homo sapiens]",8,6,11,6,686,76.8,8.85,25.28,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","UTP4","ENSG00000141076; ENSG00000262788","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",1113.1,1010,1108.2,1154.1,1180.9,1315.6,{"$f":"AVERAGE(S4994:U4994)/AVERAGE(V4994:X4994)","v":0.8851421684106724},{"$f":"LOG(Y4994,2)","v":-0.1760189004956905},{"$f":"TTEST(S4994:U4994,V4994:X4994,2,2)","v":0.08099883414192176},{"$f":"-LOG10(AA4994)","v":1.0915212321012755},{"$f":"AA4994*7309/AE4994","v":0.3091490750617787},{"$f":"-LOG10(AC4994)","v":0.5098320485219441},1915]
["Q96A26","Protein FAM162A [OS=Homo sapiens]",12,2,6,2,154,17.3,9.77,21.68,"stress response;other biological processes","other membranes;cytosol;mitochondrion","","FAM162A","ENSG00000114023","","","",534.9,531.3,498.1,637.5,644.6,379.6,0.9413853282782692,-0.08714272644180453,0.7307485306070667,0.13623204925124344,0.8151771993600504,0.08874797611963253,6552]
["Q96AA3","Protein RFT1 homolog [OS=Homo sapiens]",5,3,6,3,541,60.3,8.85,12.36,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport","other membranes;ER/Golgi","transporter activity","RFT1","ENSG00000163933","","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective RFT1 causes CDG-1n","",563.9,565.3,620.6,544.3,554.9,433.3,1.1417944535073408,0.19130295928590282,0.1684257163744533,0.7735915967625163,0.4207189203625698,0.37600795666783543,2926]
["Q96AC1","Fermitin family homolog 2 [OS=Homo sapiens]",3,2,2,2,680,77.8,6.7,1.98,"cell adhesion;cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","FERMT2","ENSG00000073712","","RAC1 GTPase cycle; RAC3 GTPase cycle; Cell-extracellular matrix interactions","",125.1,100.5,91.7,106.7,88.4,124,0.9943591350673769,-0.008161087361674379,0.9686233131142876,0.013845082434795064,0.9796136426667121,0.008945175268827894,7227]
["Q96AJ9-1","Isoform 1 of Vesicle transport through interaction with t-SNAREs homolog 1A [OS=Homo sapiens]",34,7,13,6,203,23.4,6.15,32.44,"","","","VTI1A","","","","",1675.1,1655.7,1632.9,1518.5,1449.6,1486.4,1.1143113705241892,0.15615241934206406,1.9006637040787902E-3,2.7210947186858405,0.049437548089366116,1.3059430767069473,281]
["Q96AY2","crossover junction endonuclease EME1 [OS=Homo sapiens]",4,1,1,1,570,63.2,7.05,0,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","EME1","ENSG00000154920","Homologous recombination; Fanconi anemia pathway","Fanconi Anemia Pathway; Resolution of D-loop Structures through Holliday Junction Intermediates","",11.8,21.1,17,17.9,18.2,4.9,1.2170731707317077,0.283415905831815,0.5950369007187761,0.2254561010250306,0.712620794257502,0.14714150909765072,6103]
["Q96AZ6-1","Interferon-stimulated gene 20 kDa protein [OS=Homo sapiens]",38,6,28,6,181,20.4,8.92,94.24,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ISG20","ENSG00000172183; ENSGGOG00000010365; ENSPTRG00000044668","","Interferon alpha/beta signaling","",2242.9,2321.3,2199,3119.9,2690.3,2242.1,0.8399090942960395,-0.25169490545472456,0.16845746105957035,0.7735097491515914,0.4206544526424324,0.3760745097014104,2927]
["Q96BD0","solute carrier organic anion transporter family member 4A1 [OS=Homo sapiens]",7,5,8,5,722,77.1,7.83,22.06,"transport","plasma membrane;other membranes","transporter activity","SLCO4A1","ENSG00000101187","","Transport of organic anions","",918.9,916.6,908.4,873.2,829.8,1424.6,0.8773180713646247,-0.18882810878867798,0.5407080628393612,0.2670371543368309,0.6761394749859523,0.16996370795071686,5845]
["Q96BI3-1","gamma-secretase subunit APH-1A [OS=Homo sapiens]",5,2,3,2,265,29,7.9,9.98,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle","enzyme regulator activity;other molecular function","APH1A","ENSANAG00000030676; ENSCANG00000034955; ENSCATG00000033983; ENSCCAG00000036376; ENSCSAG00000018098; ENSG00000117362; ENSGGOG00000017118; ENSMLEG00000037901; ENSMNEG00000034177; ENSNLEG00000009799; ENSPANG00000008739; ENSPPAG00000033416; ENSPPYG00000000905; ENSPTRG00000001250; ENSRBIG00000035934; ENSRROG00000045010; ENSSBOG00000025150","Notch signaling pathway; Alzheimer disease","Amyloid fiber formation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; EPH-ephrin mediated repulsion of cells; NOTCH2 Activation and Transmission of Signal to the Nucleus; Activated NOTCH1 Transmits Signal to the Nucleus; Nuclear signaling by ERBB4; NOTCH4 Activation and Transmission of Signal to the Nucleus; NRIF signals cell death from the nucleus; Regulated proteolysis of p75NTR; Noncanonical activation of NOTCH3","Alzheimer's disease and miRNA effects; Notch signaling; Alzheimer's disease; Notch signaling pathway (Netpath); Notch signaling pathway; Delta-Notch signaling pathway",370,438.7,453,556.3,523,475.5,0.8114870079753023,-0.30136009768607497,0.048150146094719466,1.317402390823263,0.23973393583535735,0.6202704845193417,1468]
["Q96BR5","Cytochrome c oxidase assembly factor 7 [OS=Homo sapiens]",39,8,16,8,231,25.7,6.02,41.77,"","mitochondrion;nucleus","","COA7","ENSG00000162377","Thermogenesis","","",2010,1984.1,1924.5,2468.3,2416.3,1953.5,0.8655328234451091,-0.20833956319427036,0.13780035741404467,0.8607496559933708,0.386337864341869,0.4130327252777268,2607]
["Q96BY9","Store-operated calcium entry-associated regulatory factor [OS=Homo sapiens]",5,1,1,1,339,37,7.58,2.79,"transport;other biological processes","other membranes;ER/Golgi;other cell component","","SARAF","ENSG00000133872","","","",90.6,84.6,83.5,96.1,99.2,189.2,0.6728218465539663,-0.5717035441644477,0.24256541542934512,0.615171120035393,0.4837409608112097,0.3153871371285667,3665]
["Q96C01","Protein FAM136A [OS=Homo sapiens]",54,7,9,7,138,15.6,7.61,27.53,"","other cell component","","FAM136A","ENSG00000035141","","","",934.9,876.3,800.7,1009.1,1089.2,838.8,0.8892785400565182,-0.16929272373093107,0.2636505693809732,0.5789712864271587,0.5013064546320326,0.2998967035396934,3844]
["Q96C92-4","Isoform 4 of Serologically defined colon cancer antigen 3 [OS=Homo sapiens]",6,1,1,1,362,40,4.88,2.97,"","","","ENTR1","","","","",23.9,21.3,26.1,18.1,23.8,34.3,0.9356955380577429,-0.09588892104943383,0.7576607979168671,0.12052518297470675,0.8345001163312812,0.07857359844305686,6636]
["Q96CM4","Nucleoredoxin-like protein 1 [OS=Homo sapiens]",4,1,3,1,212,23.9,4.84,6.94,"other biological processes","other cell component","","NXNL1","ENSG00000171773","","","",620.1,666.9,605.3,582,612.8,584.8,1.0633288379411105,0.088587824058541,0.14826503846438938,0.8289612454114917,0.4001732518966846,0.39775194354062554,2708]
["Q96CM8","Acyl-CoA synthetase family member 2, mitochondrial [OS=Homo sapiens]",19,10,15,10,615,68.1,7.55,41.94,"other metabolic processes","mitochondrion","other molecular function","ACSF2","ENSG00000167107","","Mitochondrial Fatty Acid Beta-Oxidation","Mitochondrial long chain fatty acid beta-oxidation",1137.9,1177.2,1161.2,1234.5,1116.5,1513.5,0.8995471600465778,-0.1527291760767401,0.3353203282913109,0.4745401173223543,0.5451192792440372,0.26350845799938605,4496]
["Q96CV9-2","Isoform 2 of Optineurin [OS=Homo sapiens]",41,23,58,1,571,65.2,5.17,167.77,"","","","","","","","",117.6,107.5,117.4,94.5,91.1,97.3,1.2106751502297632,0.27581181133899874,0.006303617132684854,2.2004101727729135,0.0896364545190537,1.0475153298842161,514]
["Q96CW6","Probable RNA polymerase II nuclear localization protein SLC7A6OS [OS=Homo sapiens]",42,7,11,7,309,35,4.6,35.29,"transport;developmental processes;other biological processes","nucleus;other cell component","","SLC7A6OS","ENSG00000103061","","","",394,421.5,414.3,445.7,471.8,540.2,0.8436578171091444,-0.24527012635795467,0.06081720906653573,1.2159735137350323,0.2682637182059805,0.571438060270396,1657]
["Q96D71","RalBP1-associated Eps domain-containing protein 1 [OS=Homo sapiens]",19,9,15,9,796,86.6,5.69,50,"transport","plasma membrane;other membranes;cytosol","other molecular function","REPS1","ENSG00000135597","","Cargo recognition for clathrin-mediated endocytosis","",1135,1191.4,1194,1216.3,1242,1006.1,1.0161644151945504,0.02313384875895093,0.8207344731133323,0.08579732462662816,0.8804855810928145,0.055277751682052845,6813]
["Q96DI7","U5 small nuclear ribonucleoprotein 40 kDa protein [OS=Homo sapiens]",35,10,29,10,357,39.3,8.1,88.99,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","","SNRNP40","ENSG00000060688","Spliceosome","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","mRNA processing",3499.5,3504.3,3464.3,3716.6,3518.5,2539.9,1.0709053708439897,0.09883100385504791,0.560066033750861,0.25176076513142837,0.690307359306078,0.160957496611718,5930]
["Q96DP5","Methionyl-tRNA formyltransferase, mitochondrial [OS=Homo sapiens]",7,3,7,3,389,43.8,9.66,12.69,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion","other molecular function","MTFMT","ENSG00000103707","One carbon pool by folate; Aminoacyl-tRNA biosynthesis; Metabolic pathways","Mitochondrial translation initiation","One-carbon metabolism",282.6,286.9,300.3,249.7,254.4,202.6,1.2307910004245082,0.29958579979936967,0.035228909054014594,1.4531008055600996,0.20798715369611684,0.6819634883602258,1238]
["Q96E11","Ribosome-recycling factor, mitochondrial [OS=Homo sapiens]",27,5,18,5,262,29.3,9.79,55.07,"cell organization and biogenesis;protein metabolism;other metabolic processes","mitochondrion","translation activity","MRRF","ENSG00000148187","","Mitochondrial translation termination","",1713,1732.9,1647,1519,1811.9,1246.7,1.1125699056274028,0.1538959871653337,0.3572952248644392,0.4469727879645969,0.5569355509776468,0.25419505881947335,4689]
["Q96ED9-2","Isoform 2 of Protein Hook homolog 2 [OS=Homo sapiens]",16,10,11,10,717,83,5.47,26.51,"","","","HOOK2","","","","",714.6,757.6,674.9,917.4,973.5,1729,0.5931379319870713,-0.7535604578153984,0.13509891161038584,0.8693481497456053,0.3828762873052773,0.4169415299995698,2579]
["Q96EE3","nucleoporin Seh1 [OS=Homo sapiens]",29,9,23,9,360,39.6,8.09,84.51,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","SEH1L","ENSG00000085415","Nucleocytoplasmic transport; mTOR signaling pathway; Amyotrophic lateral sclerosis","Amino acids regulate mTORC1","",2820.5,2521.1,2544.1,3056.7,2473.5,1927.1,1.0574470652917278,0.08058544532862842,0.6960941349348715,0.15733202544931368,0.7879436320642675,0.10350484997118027,6457]
["Q96EP0-1","E3 ubiquitin-protein ligase RNF31 [OS=Homo sapiens]",11,9,15,9,1072,119.6,6.57,36.21,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","RNF31","ENSG00000092098; ENSG00000285152","Necroptosis; NOD-like receptor signaling pathway; Shigellosis","Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway","Regulation of toll-like receptor signaling pathway",1094.6,1067.9,1076.3,1041.2,1028.9,1726.4,0.8531015408929277,-0.22921062553119495,0.46537063541944107,0.33220102388048933,0.6233084065018681,0.20529701577966242,5457]
["Q96ES6","Major facilitator superfamily domain-containing protein 3 [OS=Homo sapiens]",2,1,1,1,412,42.7,9.17,2.16,"transport","other membranes","transporter activity","MFSD3","ENSG00000167700","","","",40.6,44.1,57.8,40.9,54.3,90.4,0.7677801724137931,-0.38123479118810566,0.41153975595488274,0.38558820429657575,0.5838400769165835,0.2337060967643585,5152]
["Q96EX1","small integral membrane protein 12 [OS=Homo sapiens]",12,1,2,1,92,10.8,8.44,6.31,"","other membranes","","SMIM12","ENSG00000163866","","","",109.3,141.4,148.3,121,119.9,143.6,1.0377113133940183,0.05340514826051945,0.7520995449085907,0.12372467411130818,0.8310046218801043,0.08039656075085494,6615]
["Q96F10","Diamine acetyltransferase 2 [OS=Homo sapiens]",13,3,6,3,170,19.1,6.04,4.77,"other metabolic processes","other cell component","other molecular function","SAT2","ENSG00000141504","Arginine and proline metabolism; Metabolic pathways; Ferroptosis","","Ferroptosis",599.5,612.4,595.3,648.7,568.8,674.9,0.9549778059606847,-0.06646089011858228,0.42919288092989655,0.3673474903372698,0.5955896652205457,0.22505284681077767,5267]
["Q96FF9","Sororin [OS=Homo sapiens]",6,1,1,1,252,27.6,9.61,2.45,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","CDCA5","ENSG00000146670","MicroRNAs in cancer","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion","",56.4,51.8,69.3,55,48.7,42.3,1.2157534246575343,0.28185065551202726,0.17586853374994973,0.7548118571952427,0.4267673018520527,0.36980886283993264,3012]
["Q96FL9","Polypeptide N-acetylgalactosaminyltransferase 14 [OS=Homo sapiens]",3,1,1,1,552,64.3,7.72,3.54,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","GALNT14","ENSG00000158089","Mucin type O-glycan biosynthesis; Other types of O-glycan biosynthesis; Metabolic pathways","O-linked glycosylation of mucins","",51.7,50.1,50.4,49.5,59,67.5,0.8647727272727275,-0.20960707002111384,0.20332950889631027,0.6917995883032348,0.4500712842286892,0.3467186953460367,3302]
["Q96G01","Protein bicaudal D homolog 1 [OS=Homo sapiens]",11,9,13,6,975,110.7,5.81,36.9,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","BICD1","ENSG00000151746","","COPI-independent Golgi-to-ER retrograde traffic","",542.8,540.8,503.3,632.6,634,860.6,0.7460041368935689,-0.4227444640592778,0.07907034929968786,1.101986342667126,0.30578052012244367,0.5145901849563972,1890]
["Q96G03","Phosphoglucomutase-2 [OS=Homo sapiens]",35,23,61,22,612,68.2,6.73,151.91,"other metabolic processes","non-structural extracellular;cytosol;other cell component","other molecular function","PGM2","ENSG00000169299","Glycolysis / Gluconeogenesis; Pentose phosphate pathway; Galactose metabolism; Purine metabolism; Starch and sucrose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars","Neutrophil degranulation; Glycogen breakdown (glycogenolysis); Glycogen synthesis; Pentose phosphate pathway; Galactose catabolism","Clear cell renal cell carcinoma pathways; Glucuronidation",7271.3,7367.1,7442,6750.5,6653,5366.7,1.17635400794877,0.23432228522225526,0.06973142181639774,1.156571479485738,0.2863297539640736,0.5431335199106592,1780]
["Q96GA7","serine dehydratase-like [OS=Homo sapiens]",20,4,11,4,329,34.7,6.89,56.45,"other metabolic processes","cytosol","other molecular function","SDSL","ENSG00000139410","Glycine, serine and threonine metabolism; Cysteine and methionine metabolism; Valine, leucine and isoleucine biosynthesis; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids","Threonine catabolism","Clear cell renal cell carcinoma pathways",662,694.4,674.2,660.8,862.7,1307.7,0.7172223792031648,-0.4795075901421589,0.2355287950890637,0.6279559896654098,0.4773932233238954,0.32112375016781997,3606]
["Q96GD0","Pyridoxal phosphate phosphatase [OS=Homo sapiens]",36,8,19,8,296,31.7,6.55,69.41,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","PDXP","ENSG00000241360","Vitamin B6 metabolism; Metabolic pathways; Biosynthesis of cofactors","","",1794.7,1686.3,1783.2,1737.1,1658.7,1715.5,1.0299141118697788,0.04252403105309839,0.2874688269002985,0.5414092432846258,0.5190488280173621,0.28479178523239557,4048]
["Q96GM1-2","Isoform 2 of Phospholipid phosphatase-related protein type 2 [OS=Homo sapiens]",2,1,2,1,427,45.5,9.52,0,"","","","PLPPR2","","","","",81,64.1,86.2,91.4,97,71.1,0.8913294797687862,-0.16596927260905261,0.4137066171568661,0.38330753259317574,0.585097071362139,0.23277207569623043,5168]
["Q96GY0","Zinc finger C2HC domain-containing protein 1A [OS=Homo sapiens]",7,2,3,2,325,35.1,9.82,8.43,"","","other molecular function","ZC2HC1A","ENSG00000104427","","","",51.9,46.6,67.7,76,75.8,75.4,0.7315140845070423,-0.4510424527343375,0.032676007831480135,1.485771008524756,0.20256907653968476,0.6934268517358722,1179]
["Q96HA7","Tonsoku-like protein [OS=Homo sapiens]",15,17,36,17,1378,150.8,6.42,111.68,"DNA metabolism;other metabolic processes;stress response","nucleus;other cell component","other molecular function","TONSL","ENSG00000160949","","","",1729.6,1690,1794.9,1758,1805,2267.3,0.8943793629830369,-0.16104119524105445,0.28228848004870827,0.5493068446775989,0.5154250563767195,0.28783447289873126,4003]
["Q96HE7","ERO1-like protein alpha [OS=Homo sapiens]",47,15,84,13,468,54.4,5.68,301.52,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","ERO1A","ENSG00000197930","Protein processing in endoplasmic reticulum; Vibrio cholerae infection; Lipid and atherosclerosis","Insulin processing; Detoxification of Reactive Oxygen Species","",8324.3,8515.6,8509.3,8106.4,8491.4,6666.4,1.089622682060849,0.12382864054422092,0.2816048687529025,0.5503598408145833,0.5146911692210464,0.288453283064132,3999]
["Q96HY7","Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial [OS=Homo sapiens]",10,7,11,7,919,103,6.93,32.57,"other metabolic processes;developmental processes","mitochondrion","other molecular function","DHTKD1","ENSG00000181192","Lysine degradation; Tryptophan metabolism; Metabolic pathways","Glyoxylate metabolism and glycine degradation","Integrated breast cancer pathway",691.3,662.7,694.5,664.1,649,558.4,1.0945765428800427,0.13037284458033918,0.16259380635839177,0.7888960018883517,0.4146539185880968,0.3823142260657045,2866]
["Q96I15-1","selenocysteine lyase [OS=Homo sapiens]",20,7,12,7,445,48.1,7.12,36.49,"other metabolic processes","cytosol;ER/Golgi;other cell component","other molecular function","SCLY","ENSG00000132330","Selenocompound metabolism; Metabolic pathways","Metabolism of ingested SeMet, Sec, MeSec into H2Se","",1491.4,1490.7,1499.8,1424.6,1481.6,3511.3,0.6983872224386445,-0.5179009309558554,0.40036868606271164,0.3975398972316379,0.5777482184466652,0.23826138504396416,5065]
["Q96IJ6","Mannose-1-phosphate guanyltransferase alpha [OS=Homo sapiens]",32,11,44,11,420,46.3,7.21,135.66,"other metabolic processes","other cell component","other molecular function","GMPPA","ENSG00000144591","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars","Synthesis of GDP-mannose","",4669.4,4584.3,4578.6,4441.5,4357.7,5245,0.9849119209353328,-0.021933382411260607,0.8160587557344047,0.08827857118168378,0.8768852463485391,0.05705723689441417,6802]
["Q96IV0","Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase [OS=Homo sapiens]",18,12,23,12,654,74.3,6.89,58.16,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","NGLY1","ENSG00000151092","Protein processing in endoplasmic reticulum","N-glycan trimming in the ER and Calnexin/Calreticulin cycle","",2753.7,2795.5,2891.5,2981.9,2885.8,3108.2,0.940373667264564,-0.08869395427874308,0.07935596437212776,1.100420426230396,0.3059138943016254,0.5144007973484704,1896]
["Q96JB2-1","Conserved oligomeric Golgi complex subunit 3 [OS=Homo sapiens]",15,10,13,10,828,94,5.57,37.33,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi","","COG3","ENSG00000136152","","COPI-mediated anterograde transport; Retrograde transport at the Trans-Golgi-Network; Intra-Golgi traffic","",778.3,804.4,792.4,801.7,813.5,883.3,0.9506103662197317,-0.07307396085466963,0.19632092914866106,0.7070333991811426,0.44314690276329943,0.3534522817145246,3238]
["Q96JJ7-1","Protein disulfide-isomerase TMX3 [OS=Homo sapiens]",43,17,88,16,454,51.8,4.91,313.97,"protein metabolism;other metabolic processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","TMX3","ENSG00000166479; ENSGGOG00000005485","","Platelet degranulation","",7449,7747.2,7715,6808.6,7237.5,6445.9,1.118055826664064,0.160992226500049,0.03114464191264728,1.5066166580874913,0.20020772888262003,0.6985191608912532,1137]
["Q96JQ2","Calmin [OS=Homo sapiens]",10,8,10,8,1002,111.6,4.94,25.17,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;nucleus;other cell component","cytoskeletal activity","CLMN","ENSG00000165959","","","Vitamin D receptor pathway",567.1,552.7,544,586.1,652.4,614.1,0.8980891719745224,-0.15506939649283324,0.03655037354269585,1.437108180219046,0.20985599389125215,0.6780786219887284,1273]
["Q96K17-1","transcription factor BTF3 homolog 4 [OS=Homo sapiens]",29,4,19,2,158,17.3,6.35,49.87,"","","","Btf3l4; BTF3L4; LOC108587672; LOC110308160; LOC111143096","ENSAMEG00000009159; ENSANAG00000025045; ENSCAFG00000003782; ENSCANG00000032994; ENSCATG00000029142; ENSCCAG00000034219; ENSCGRG00001021460; ENSCGRG00015007601; ENSCJAG00000021582; ENSCJAG00000023403; ENSCPOG00000036248; ENSECAG00000024180; ENSFCAG00000024164; ENSG00000134717; ENSGGOG00000010677; ENSHGLG00000000408; ENSLCNG00005020988; ENSMFAG00000046175; ENSMLEG00000043474; ENSMMUG00000003636; ENSMNEG00000032806; ENSMODG00000000770; ENSMUSG00000028568; ENSMUSG00000114133; ENSNLEG00000016041; ENSOCUG00000001517; ENSPANG00000025278; ENSPCOG00000026062; ENSPPAG00000025800; ENSPTRG00000000735; ENSRBIG00000044688; ENSRFEG00010003696; ENSRNOG00000008512; ENSSHAG00000025846; ENSSSCG00000038762; ENSSSCG00070030088; ENSSSUG00005008763; ENSSTOG00000006129; ENSTSYG00000033616; ENSUMAG00000022798","","","",723,780.6,674.6,839.2,963.3,434.5,0.9737147966025927,-0.03842882954097211,0.909848928558082,0.04103071200879807,0.9406061978544584,0.026592163921724515,7070]
["Q96KG9","N-terminal kinase-like protein [OS=Homo sapiens]",35,22,48,22,808,89.6,6.3,144.42,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;kinase activity;other molecular function","SCYL1","ENSG00000142186","","","",5486.6,5493.7,5611,5291.8,5294.8,4302.1,1.114355182117982,0.15620914094452323,0.16338506964783361,0.7867876324169195,0.415511995148231,0.3814164343311534,2874]
["Q96KM6","zinc finger protein 512B [OS=Homo sapiens]",8,5,5,5,892,97.2,9.83,17.38,"","nucleus","nucleic acid binding activity;other molecular function","ZNF512B","ENSG00000196700","","RHOV GTPase cycle","",286.2,292.3,321.7,364.4,357.6,324.9,0.8598720030566434,-0.2178061726291918,0.04062454107244054,1.3912115321258678,0.2201073170485307,0.6573655199137991,1349]
["Q96L91-5","Isoform 5 of E1A-binding protein p400 [OS=Homo sapiens]",5,13,17,13,3122,339.5,9.16,50.24,"","","","EP400","","","","",1316.9,1259.8,1285.2,1548.5,1447.1,2157.1,0.7494905583480506,-0.41601779084397045,0.12504639593987513,0.9029288208945401,0.3686825768150655,0.4333473857783885,2479]
["Q96LT4-1","Sphingomyelin synthase-related protein 1 [OS=Homo sapiens]",3,1,1,1,415,48.3,8.07,3.67,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi","other molecular function","SAMD8","ENSG00000156671; ENSGGOG00000011029; ENSPTRG00000002656","","Sphingolipid de novo biosynthesis","",31.6,32.2,25.3,28.5,23.2,22,1.2089552238805972,0.2737608124268525,0.1596520070552129,0.7968256173843243,0.411748948329764,0.3853675014117929,2834]
["Q96LZ7-1","Regulator of microtubule dynamics protein 2 [OS=Homo sapiens]",3,1,1,1,410,47.4,6.54,2.41,"","other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cell component","cytoskeletal activity","RMDN2","ENSG00000115841","","","",35.7,26.3,34.8,31.9,29.7,34.7,1.0051921079958461,0.007471249431134937,0.9624349900397016,0.016628596282374158,0.9759208299389815,0.01058541236940774,7208]
["Q96MG8-1","Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 [OS=Homo sapiens]",9,4,6,4,357,40.7,5.66,10.9,"protein metabolism;other metabolic processes","other membranes;other cell component","other molecular function","PCMTD1","ENSG00000168300; ENSGGOG00000025636; ENSPPAG00000008533; ENSPPYG00000018582; ENSPTRG00000020242","","","",857.2,837.6,807.1,769.1,745.6,702.2,1.1285578961613063,0.17448043214274803,0.01769165249726515,1.752231599711792,0.15375539607908562,0.8131696336257312,841]
["Q96MW5","Conserved oligomeric Golgi complex subunit 8 [OS=Homo sapiens]",17,9,13,9,612,68.4,5.2,41.01,"transport","other membranes;ER/Golgi","","COG8","ENSG00000213380","","COPI-mediated anterograde transport; Retrograde transport at the Trans-Golgi-Network; Intra-Golgi traffic","",646.4,690.4,653.9,740.8,766.3,1032.7,0.7838018741633198,-0.3514390722880223,0.12431215495130778,0.9054864049850919,0.36844993533621595,0.4336215153608318,2466]
["Q96N11","Uncharacterized protein C7orf26 [OS=Homo sapiens]",4,1,2,1,449,50,7.69,4.92,"","","","C7orf26","ENSG00000146576","","","",19.6,21.9,18.8,16.9,20.5,24.2,0.9788961038961039,-0.030772348794816516,0.8599192973508915,0.06554230498873052,0.9055107541186667,0.04310638750711694,6941]
["Q96NC0","Zinc finger matrin-type protein 2 [OS=Homo sapiens]",14,2,2,2,199,23.6,9.01,4.03,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","ZMAT2","ENSG00000146007","Spliceosome","","",130.2,117.9,139.5,140.3,138.7,81.7,1.0745772109786527,0.10376914762751088,0.680977653141348,0.1668671395947619,0.7778192947038775,0.10912128787988014,6399]
["Q96ND0","Protein FAM210A [OS=Homo sapiens]",11,3,8,3,272,30.8,9.76,22.34,"","other membranes;mitochondrion;other cell component","","FAM210A","ENSG00000177150","","","",1412.9,1466.8,1431.4,1388.2,1360,1193.9,1.093604931381751,0.12909165360155975,0.12107251045204181,0.9169544523500304,0.3653670433088248,0.4372706292730908,2422]
["Q96P16-1","Regulation of nuclear pre-mRNA domain-containing protein 1A [OS=Homo sapiens]",25,6,11,5,312,35.7,7.55,38.34,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","LOC111142439; P15RS; RPRD1A","ENSAMEG00000000830; ENSANAG00000021312; ENSBIXG00000008485; ENSBIXG00005019871; ENSBTAG00000005497; ENSCAFG00000017862; ENSCCAG00000025615; ENSCJAG00000021044; ENSDLEG00000001661; ENSG00000141425; ENSGGOG00000007369; ENSLCNG00005017687; ENSMPUG00000001133; ENSNLEG00000006228; ENSOARG00000005585; ENSPCTG00005006209; ENSPPAG00000027698; ENSPPYG00000009111; ENSPTRG00000009974; ENSRFEG00010007667; ENSSBOG00000026758; ENSSSUG00005007348; ENSSTOG00000003343; ENSTSYG00000006414; ENSTTRG00000007088; ENSUMAG00000002096; ENSVVUG00000027590","","RNA polymerase II transcribes snRNA genes; RNA polymerase II transcribes snRNA genes","",432,434.5,417.2,467.1,485.1,466.2,0.9050338409475466,-0.1439563565540432,0.005384268109909556,2.2688733225294024,0.08390962817767365,1.0761882033605128,469]
["Q96PE3-1","Type I inositol 3,4-bisphosphate 4-phosphatase [OS=Homo sapiens]",32,25,69,25,977,109.9,6.96,235.14,"other metabolic processes;signal transduction","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","INPP4A","ENSG00000040933","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of IP2, IP, and Ins in the cytosol","Insulin signaling",5555.4,5378.6,5466,5698.8,5755.4,6536.2,0.9115972963358235,-0.13353144910017228,0.12611262614629629,0.8992414305469965,0.3698865106353449,0.4319315066501555,2492]
["Q96PU5","E3 ubiquitin-protein ligase NEDD4-like [OS=Homo sapiens]",11,8,12,5,975,111.9,5.82,32.67,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","NEDD4L","ENSG00000049759","Ubiquitin mediated proteolysis; Endocytosis; Tight junction; Aldosterone-regulated sodium reabsorption","Stimuli-sensing channels; Antigen processing: Ubiquitination & Proteasome degradation; Budding and maturation of HIV virion; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity","TGF-beta signaling pathway",461.5,489,531.2,434.4,478.7,567.9,1.000472653612424,6.8173392339023961E-4,0.9960391156904693,1.7236059588738386E-3,0.9974037397700563,1.1290077253817634E-3,7299]
["Q96PZ2","Protein FAM111A [OS=Homo sapiens]",9,4,5,4,611,70.2,8.53,22.54,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","FAM111A","ENSG00000166801","","","",230.4,220.6,260.5,183.8,233.5,332.3,0.9491728922091781,-0.07525719624534227,0.7929462664673566,0.1007562413928419,0.8586139646829495,0.06620205233989385,6750]
["Q96QC0","Serine/threonine-protein phosphatase 1 regulatory subunit 10 [OS=Homo sapiens]",20,19,31,19,940,99,9.17,61.29,"transport;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","PPP1R10","ENSG00000204569; ENSG00000206489; ENSG00000227804; ENSG00000230995; ENSG00000231737; ENSG00000235291; ENSG00000238104","","","",4455.1,4719.1,4624.4,4978.2,5265.5,4921,0.9099157912784295,-0.136195058506143,0.025823499410798516,1.5879849056861477,0.18360307119992839,0.7361200584614315,1028]
["Q96QE3-1","ATPase family AAA domain-containing protein 5 [OS=Homo sapiens]",4,4,4,4,1844,207.4,9.19,6.82,"stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ATAD5","ENSG00000176208","","","",157.6,171.4,186.3,260.8,289.2,282.7,0.6188303110363876,-0.6923842314700001,8.9476172064070216E-4,3.0482926040011127,0.03406152820918173,1.4677358708206893,192]
["Q96QT6-1","PHD finger protein 12 [OS=Homo sapiens]",3,2,2,2,1004,109.6,7.74,5.82,"other biological processes","nucleus;other cell component","other molecular function","PHF12","ENSG00000109118","","","",66.5,71.5,61.8,66,84.1,52.2,0.9876421156697974,-0.017939736765864456,0.9353457937903726,0.029027802419671383,0.9569488251419139,0.019111286416188464,7144]
["Q96R06","Sperm-associated antigen 5 [OS=Homo sapiens]",22,16,29,16,1193,134.3,5,88.13,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity","SPAG5","ENSG00000076382","","","",1672.4,1690.4,1655.3,1794.8,1756.3,4725.7,0.606285037695728,-0.7219318757943086,0.33136056773565853,0.4796991743528062,0.5421791783254821,0.26585716494067174,4467]
["Q96RP9","Elongation factor G, mitochondrial [OS=Homo sapiens]",38,27,168,1,751,83.4,7.01,461.06,"protein metabolism;other metabolic processes","mitochondrion","nucleic acid binding activity;other molecular function","GFM1","ENSG00000168827","","Mitochondrial translation elongation","",455.7,443.1,422.1,459.4,406.4,581,0.9129803704727676,-0.1313442529977246,0.4696754300799189,0.32820215827493676,0.6259769727305119,0.20344164250843885,5484]
["Q96RS0","Trimethylguanosine synthase [OS=Homo sapiens]",11,6,7,6,853,96.6,4.94,20.72,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","TGS1","ENSG00000137574","","Heme signaling; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); RORA activates gene expression; snRNP Assembly","",343.3,343.6,347.7,389.3,398.7,458.4,0.8300706033376124,-0.268694041857914,0.03120257541758245,1.5058095584339903,0.1995272298574892,0.699997826945299,1143]
["Q96RT7","gamma-tubulin complex component 6 [OS=Homo sapiens]",2,4,5,4,1819,200.4,6.32,14.98,"cell cycle OR cell proliferation;cell organization and biogenesis","cytosol;cytoskeleton","cytoskeletal activity","TUBGCP6","ENSG00000128159","","Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes","15q11.2 copy number variation syndrome",376.3,305.6,309.1,384,345.4,348.5,0.919380276463494,-0.12126637864946961,0.32972081869897285,0.4818536304709261,0.5408279766316859,0.26694085075262564,4456]
["Q96S59-1","Ran-binding protein 9 [OS=Homo sapiens]",16,8,14,8,729,77.8,6.79,41.53,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","RANBP9","ENSG00000010017","","RAF/MAP kinase cascade; L1CAM interactions; MET activates RAS signaling","Brain-derived neurotrophic factor (BDNF) signaling pathway; Ciliary landscape",629,619.6,616.2,599.9,632.8,2635.3,0.4821096173733196,-1.0525668852353371,0.3773129337191349,0.42329830758305487,0.565466522975837,0.2475931012906482,4877]
["Q96SB8","structural maintenance of chromosomes protein 6 [OS=Homo sapiens]",18,16,39,16,1091,126.2,6.99,104.02,"cell organization and biogenesis;DNA metabolism;stress response;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMC6","ENSG00000163029","","SUMOylation of DNA damage response and repair proteins","",2440.5,2461.1,2404.9,2402.4,2450.8,2713.2,0.9656507718333684,-0.0504265630088379,0.4263423202504425,0.3702415556029147,0.5938890830399246,0.22629465791728068,5247]
["Q96SK2","Transmembrane protein 209 [OS=Homo sapiens]",15,6,13,6,561,62.9,8.63,35.02,"","other membranes","","TMEM209","ENSG00000146842","","","",1402.8,1414,1456.8,1442.1,1503,2114.3,0.8446851405304979,-0.2435144231323913,0.29057062774240794,0.5367482883659417,0.5215571508274214,0.28269809581067096,4072]
["Q96SU4","Oxysterol-binding protein-related protein 9 [OS=Homo sapiens]",18,12,31,12,736,83.1,6.18,87.81,"other metabolic processes;transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","OSBPL9","ENSG00000117859","","Synthesis of bile acids and bile salts","",4075,3893,3948.9,3944.6,3654,3240.4,1.0994464433988373,0.1367773288633918,0.16425308198590582,0.7844864727458701,0.41655995011623376,0.3803224873398677,2882]
["Q96SZ5","2-aminoethanethiol dioxygenase [OS=Homo sapiens]",22,4,12,4,270,29.7,6.04,35.36,"","cytosol","other molecular function","ADO","ENSG00000181915","Taurine and hypotaurine metabolism; Metabolic pathways","Degradation of cysteine and homocysteine","",684,715.3,692.8,864.8,833.8,1452,0.6640322478258109,-0.5906747890852279,0.1545385258387076,0.8109632348577059,0.4067418384426049,0.3906811527239906,2777]
["Q96T66-1","Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 [OS=Homo sapiens]",4,1,1,1,252,28.3,9.22,1.77,"other metabolic processes","mitochondrion;nucleus","other molecular function","NMNAT3","ENSG00000163864","Nicotinate and nicotinamide metabolism; Metabolic pathways; Biosynthesis of cofactors","Nicotinate metabolism","NAD+ metabolism",60.5,47.9,69,56.9,61.1,125.5,0.7285420944558522,-0.45691576266864065,0.39289233721713623,0.4057264413759426,0.5743300185440098,0.24083848382798842,5000]
["Q99081-1","Transcription factor 12 [OS=Homo sapiens]",7,4,4,4,682,72.9,7.02,8.37,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TCF12","ENSG00000140262","","RUNX1 regulates transcription of genes involved in differentiation of HSCs; Myogenesis; NGF-stimulated transcription","",127.2,138.9,139.3,270.7,294.8,254.5,0.49439024390243913,-1.0162778209259091,3.644797955407037E-4,3.438326541223604,0.022576125640737316,1.6463505866457566,118]
["Q99439","Calponin-2 [OS=Homo sapiens]",60,13,71,13,309,33.7,7.33,202.24,"cell organization and biogenesis;stress response;developmental processes;other biological processes","non-structural extracellular;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","CNN2","ENSG00000064666","","Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","Myometrial relaxation and contraction pathways; Burn wound healing",8750.7,8726.1,8775.3,9125.7,9593.1,9100.6,0.9436616174324394,-0.08365847086075491,0.03139203047118977,1.5031805927448718,0.19986441699819338,0.6992645189228537,1148]
["Q99471-1","prefoldin subunit 5 [OS=Homo sapiens]",44,5,13,5,154,17.3,6.33,46.55,"developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","LOC101567244; PFDN5","ENSCJAG00000018477; ENSG00000123349; ENSGGOG00000026308; ENSMFAG00000003143; ENSMMUG00000022030; ENSNLEG00000017706; ENSPPAG00000037126; ENSPPYG00000004575; ENSPTRG00000005010","","Prefoldin mediated transfer of substrate  to CCT/TriC","Cellular proteostasis",1306.9,1525.2,1475.1,1134.8,1939.2,971.7,1.064636527671355,0.09036097108134349,0.7900566574054708,0.1023417629927893,0.8562461608802767,0.06740136272550225,6744]
["Q99543-1","dnaJ homolog subfamily C member 2 [OS=Homo sapiens]",35,20,42,20,621,72,8.7,115.84,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;cytosol;nucleus;other cell component","translation activity;other molecular function","DNAJC2","ENSG00000105821","","Regulation of HSF1-mediated heat shock response","",4891.7,5191,5289.1,5345.8,5509,4623.6,0.9931129832540831,-0.009970237045088377,0.9105781752305038,0.04068276308839251,0.9412269668731088,0.02630563844840573,7071]
["Q99567","Nuclear pore complex protein Nup88 [OS=Homo sapiens]",29,17,57,17,741,83.5,5.69,186.33,"cell cycle OR cell proliferation;other metabolic processes;transport","cytosol;nucleus","transporter activity;other molecular function","NUP88","ENSG00000108559","Nucleocytoplasmic transport; Amyotrophic lateral sclerosis","HCMV Early Events; ISG15 antiviral mechanism; tRNA processing in the nucleus; HCMV Late Events; Transcriptional regulation by small RNAs; Viral Messenger RNA Synthesis; SUMOylation of DNA damage response and repair proteins; Rev-mediated nuclear export of HIV RNA; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)","Ciliary landscape",5836.8,5613.7,6029,5566.2,5504.2,4704.5,1.1080577372915201,0.14803305750076257,0.1333571181441195,0.8749837982102682,0.38000279786174246,0.42021320577413024,2565]
["Q99576","TSC22 domain family protein 3 [OS=Homo sapiens]",43,4,5,3,134,14.8,4.54,11.75,"stress response;other biological processes","cytosol;nucleus","","TSC22D3","ENSG00000157514","","Stimuli-sensing channels","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway",512.9,557.4,511.2,753.2,790.2,501.5,0.77338745170913,-0.37073673815202285,0.16827570469140485,0.773978582064054,0.42063171189790627,0.376097988465904,2924]
["Q99607","ETS-related transcription factor Elf-4 [OS=Homo sapiens]",1,1,1,1,663,70.7,5.6,2.6,"cell cycle OR cell proliferation;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ELF4","ENSG00000102034","","","TYROBP causal network in microglia",81.2,83.6,124.3,95.6,118,87,0.9617431803060547,-0.056276400439314964,0.830311761957141,0.08075880994269859,0.886078065140129,0.052528014268623316,6849]
["Q99638","cell cycle checkpoint control protein rad9a [OS=Homo sapiens]",10,2,5,2,391,42.5,5.66,20.5,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus","other molecular function","RAD9A","ENSG00000172613","Cellular senescence","Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Activation of ATR in response to replication stress; Presynaptic phase of homologous DNA pairing and strand exchange; HDR through Single Strand Annealing (SSA)","Androgen receptor signaling pathway; miRNA regulation of DNA damage response; ATM signaling pathway; ATR signaling; DNA IR-double strand breaks and cellular response via ATM; DNA damage response",142.5,134.8,152.3,125.8,124.4,126.6,1.1401273885350323,0.18919502837262997,0.026104767563365477,1.5832801693905256,0.18452586665438905,0.7339427462644764,1034]
["Q99717","mothers against decapentaplegic homolog 5 [OS=Homo sapiens]",10,5,13,1,465,52.2,7.71,36.7,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMAD5","ENSG00000113658","TGF-beta signaling pathway; Signaling pathways regulating pluripotency of stem cells","Signaling by BMP","Differentiation of white and brown adipocyte; BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation; BMP signaling in eyelid development; Embryonic stem cell pluripotency pathways; Genotoxicity pathway; Neovascularisation processes; Osteoblast differentiation and related diseases; TGF-beta receptor signaling in skeletal dysplasias; Network map of SARS-CoV-2 signaling pathway; TGF-beta receptor signaling",1336.1,1317.9,1285.4,1294.6,1438.7,500,1.2183836946772648,0.2849685398419345,0.4657442999292856,0.33185245156732057,0.6233519663400748,0.20526666621889098,5461]
["Q99732","Lipopolysaccharide-induced tumor necrosis factor-alpha factor [OS=Homo sapiens]",4,1,1,1,161,17.1,6.44,2.51,"other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","LITAF","ENSG00000189067","Lysosome","","Intracellular trafficking proteins involved in CMT neuropathy",498.1,580,597.3,483,545.1,748,0.9433027419627272,-0.08420723360141298,0.7151634959185629,0.1455946613342497,0.8023223317987377,0.09565111949888022,6515]
["Q99766-1","ATP synthase subunit s, mitochondrial [OS=Homo sapiens]",5,1,1,1,215,24.9,7.56,2.9,"other metabolic processes;transport","other membranes;mitochondrion;other cell component","transporter activity;other molecular function","DMAC2L","ENSG00000125375","","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",107,102.6,88.7,90.2,93.5,63.2,1.208181449979749,0.27283714119243074,0.1965712237758465,0.7064800585794903,0.4433011646336507,0.35330112772772726,3241]
["Q99832","T-complex protein 1 subunit eta [OS=Homo sapiens]",67,29,204,29,543,59.3,7.65,700.66,"transport;other biological processes","cytosol;cytoskeleton;other cell component","other molecular function","CCT7","ENSG00000135624","","Formation of tubulin folding intermediates by CCT/TriC; Association of TriC/CCT with target proteins during biosynthesis; RHOBTB1 GTPase cycle; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate  to CCT/TriC; RHOBTB2 GTPase cycle; Folding of actin by CCT/TriC","VEGFA-VEGFR2 signaling pathway; 16p11.2 proximal deletion syndrome",26110.4,25681.9,25853.9,24108.4,23910.8,21103.7,1.1233064584963885,0.16775157496687765,0.04393167232876229,1.3572222643119694,0.22870127710179744,0.6407314102217829,1404]
["Q99856","AT-rich interactive domain-containing protein 3A [OS=Homo sapiens]",21,12,15,12,593,62.9,4.91,37.81,"other biological processes","other membranes;cytosol;nucleus","nucleic acid binding activity;other molecular function","ARID3A","ENSG00000116017","","TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest","",1226.5,1152.2,1211.8,1251.8,1304.7,1370.3,0.9143577467658143,-0.1291693579358809,0.052644290365047135,1.2786487241445363,0.2501801809350647,0.6017470977259756,1538]
["Q99962","Endophilin-A1 [OS=Homo sapiens]",24,8,26,3,352,39.9,5.45,63.46,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SH3GL2","ENSG00000107295","Endocytosis","Golgi Associated Vesicle Biogenesis; MHC class II antigen presentation; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; Lysosome Vesicle Biogenesis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Retrograde neurotrophin signalling","EGF/EGFR signaling pathway",259.1,269.8,279,273.3,259.5,487.1,0.7921364839690167,-0.33617906889928845,0.39308964080245046,0.40550840110896985,0.574388681452441,0.2407941266194807,5002]
["Q99996-2","Isoform 2 of A-kinase anchor protein 9 [OS=Homo sapiens]",29,95,152,1,3907,452.7,4.98,440.93,"cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","AKAP9","ENSG00000127914","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Signaling by BRAF and RAF1 fusions; Phase 3 - rapid repolarisation; Phase 2 - plateau phase","G protein signaling pathways; NO/cGMP/PKG mediated neuroprotection",67.3,55,57.7,87,69.6,84.1,0.7478188616535106,-0.4192392352574597,0.03660174558390933,1.4364982020541708,0.20982130076297514,0.6781504249401719,1275]
["Q9BPZ7","Target of rapamycin complex 2 subunit MAPKAP1 [OS=Homo sapiens]",6,2,2,2,522,59.1,7.55,4.33,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","MAPKAP1","ENSG00000119487","mTOR signaling pathway","PIP3 activates AKT signaling; CD28 dependent PI3K/Akt signaling; Regulation of TP53 Degradation; Constitutive Signaling by AKT1 E17K in Cancer; VEGFR2 mediated vascular permeability","Target of rapamycin (TOR) signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Head and neck squamous cell carcinoma; Interferon type I signaling pathways",101.5,102.4,101.4,111.5,137.3,208.4,0.6677602799650043,-0.5825978140076984,0.1554764308192153,0.8083354377687855,0.4074497070124219,0.3899259901508624,2789]
["Q9BQ75","Protein CMSS1 [OS=Homo sapiens]",11,2,4,2,279,31.9,9.19,14.34,"","","","CMSS1","ENSG00000184220","","","",567.9,616.3,554.7,718.7,725.5,180.7,1.0701581635792972,0.09782403489619111,0.8443475145128059,0.07347877070534234,0.8956946275143829,0.047840030728995196,6890]
["Q9BQA9-1","Uncharacterized protein C17orf62 [OS=Homo sapiens]",21,5,25,5,187,20.8,6.8,67.12,"other metabolic processes;stress response","other membranes;ER/Golgi","","C17orf62; CYBC1","ENSG00000178927; ENSGGOG00000001586; ENSPPAG00000037586; ENSPTRG00000009804","","","",3242.8,3174,3281.7,3330.1,3147.7,2832.8,1.041662191480678,0.05888749096476697,0.433394081334212,0.36311702393785195,0.5991445697884917,0.22246837245899034,5287]
["Q9BQG0","Myb-binding protein 1A [OS=Homo sapiens]",42,43,162,43,1328,148.8,9.28,491.28,"other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MYBBP1A","ENSG00000132382","","B-WICH complex positively regulates rRNA expression","Energy metabolism",13711.4,13380.3,13546.9,19236,18750.8,21339.1,0.6850060428918904,-0.5458113797898054,1.4677722174918743E-3,2.8333413370371017,0.04343298436294781,1.3621803284127945,247]
["Q9BRD0","BUD13 homolog [OS=Homo sapiens]",14,7,12,7,619,70.5,9.86,32.44,"RNA metabolism OR transcription;other metabolic processes","nucleus","","BUD13","ENSG00000137656","","","",899.5,878.7,903.9,1060.8,1097,1046.7,0.8369792479325947,-0.25673624185592897,4.9771916355711282E-4,3.3030156374016797,0.024579928151614444,1.6094193909126642,148]
["Q9BRJ2","39S ribosomal protein L45, mitochondrial [OS=Homo sapiens]",43,12,47,12,306,35.3,9.03,113.97,"","other membranes;mitochondrion;translational apparatus","","MRPL45","ENSG00000277936","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",5599.2,5587.9,5473.4,5012.8,5002,5541.4,1.070987773363675,0.09894201005242693,0.1138964832381031,0.9434896853490383,0.35636532362469847,0.4481045619054272,2336]
["Q9BRP8","Partner of Y14 and mago [OS=Homo sapiens]",9,1,2,1,204,22.6,9.45,7.99,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","translation activity","PYM1","ENSG00000170473","Nucleocytoplasmic transport; mRNA surveillance pathway","","",64,68.5,78.7,146,67.2,179.7,0.5375413591244591,-0.8955523331002334,0.14595421156676483,0.8357833687553313,0.3976069073207172,0.40054607954329735,2683]
["Q9BRR6-1","ADP-dependent glucokinase [OS=Homo sapiens]",28,8,22,8,497,54.1,6.2,86.21,"other metabolic processes","non-structural extracellular;other membranes;ER/Golgi","kinase activity;other molecular function","ADPGK","ENSG00000159322; ENSPPAG00000038547; ENSPTRG00000007256","Glycolysis / Gluconeogenesis; Metabolic pathways; Carbon metabolism","Glycolysis","",1912,1860.8,2023.4,1895.7,1858.2,1815.7,1.0406851479459924,0.05753365729929236,0.22920508900491712,0.6397757440248127,0.47256981538418597,0.3255340216599251,3545]
["Q9BRX5","DNA replication complex GINS protein PSF3 [OS=Homo sapiens]",19,3,3,3,216,24.5,5.34,11.94,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes","nucleus","","GINS3","ENSG00000181938","","Unwinding of DNA","",460.7,447.4,429,446.3,507.4,448.6,0.9535049561434784,-0.06868765746623123,0.37924191567118676,0.42108366833112015,0.5674266451669814,0.24609027450193907,4885]
["Q9BSB4","Autophagy-related protein 101 [OS=Homo sapiens]",19,4,6,4,218,25,6.15,20.06,"cell organization and biogenesis;other metabolic processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","ATG101","ENSG00000123395","Autophagy; Autophagy; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration","Macroautophagy","Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Alzheimer's disease",522.5,529.4,543.3,596.5,512.2,292,1.1388591418576426,0.18758932043485063,0.5154443998020372,0.2878181745346131,0.6582881562385269,0.1815839585590292,5723]
["Q9BSE5","Agmatinase, mitochondrial [OS=Homo sapiens]",12,5,17,5,352,37.6,7.59,48.36,"other metabolic processes","mitochondrion","other molecular function","AGMAT","ENSG00000116771","Arginine and proline metabolism; Metabolic pathways","Agmatine biosynthesis","",2449.7,2229.4,2345.9,2128.8,2055.2,2175.5,1.104646591713185,0.14358488370393077,0.03786695528590848,1.4217396131703737,0.21339211733593297,0.6708216273704808,1297]
["Q9BSJ8","Extended synaptotagmin-1 [OS=Homo sapiens]",36,32,121,32,1104,122.8,5.83,371.03,"cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi","other molecular function","ESYT1","ENSG00000139641","","RAC1 GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; Glycosphingolipid metabolism; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle","",11604.7,11597.4,11762.9,11421.1,11325.1,11635.5,1.0169654205580294,0.02427062468450714,0.14182350119094586,0.8482517974191118,0.39160860226846367,0.40714777683648706,2647]
["Q9BT17-1","Mitochondrial ribosome-associated GTPase 1 [OS=Homo sapiens]",10,3,8,3,334,37.2,9.47,26.68,"other biological processes","other membranes;mitochondrion;translational apparatus","other molecular function","MTG1","ENSG00000148824","","","",490.2,461.5,496.1,421.3,467.8,732,0.8930972796249461,-0.16311076703385455,0.5848117541377776,0.23298390707298028,0.70581061938458,0.15131181168102367,6056]
["Q9BT30","Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial [OS=Homo sapiens]",10,1,1,1,221,24.5,7.11,0,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","mitochondrion","other molecular function","ALKBH7","ENSG00000125652","","","",56.8,53.3,53.3,95,98.1,219.2,0.3963133640552996,-1.3352864777423812,0.11246322245331777,0.9489894766362924,0.35461332739918017,0.4502449463798966,2318]
["Q9BTC0","Death-inducer obliterator 1 [OS=Homo sapiens]",18,31,59,31,2240,243.7,7.88,180.8,"RNA metabolism OR transcription;other metabolic processes;signal transduction","cytoskeleton;nucleus;other cell component","other molecular function","DIDO1","ENSG00000101191","","","",5098.5,5062.7,5329.1,6515.9,6468.9,8253.1,0.7293706063217174,-0.4552760347367327,0.03194489098612277,1.4955985895855621,0.20110698382219755,0.696572847440163,1161]
["Q9BTE3-1","Mini-chromosome maintenance complex-binding protein [OS=Homo sapiens]",19,10,22,10,642,72.9,5.87,64.67,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","MCMBP","ENSG00000197771; ENSGGOG00000006006; ENSPTRG00000003000","","","",2072.7,1929,1970.3,2513.5,2607.7,2619,0.7715562905351283,-0.37415667935722463,4.0731691266293705E-4,3.3900675567107266,0.023441569406719737,1.6300133157827106,127]
["Q9BTU6","Phosphatidylinositol 4-kinase type 2-alpha [OS=Homo sapiens]",30,15,31,14,479,54,8.29,65.4,"cell organization and biogenesis;other metabolic processes;transport","plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","PI4K2A","ENSG00000155252","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane","Thymic stromal lymphopoietin (TSLP) signaling pathway; Wnt signaling pathway",3431.3,3650.5,3556.8,3044.6,3218.8,2953.2,1.154286830284487,0.2070017657605325,0.009197411772165523,2.0363343695251523,0.11185338210109454,0.9513508796439187,601]
["Q9BTZ2","dehydrogenase/reductase sdr family member 4 [OS=Homo sapiens]",41,8,10,7,278,29.5,8.56,37.38,"other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle","other molecular function","DHRS4","ENSG00000157326; ENSG00000284807","Retinol metabolism; Metabolic pathways; Peroxisome","Peroxisomal protein import; RA biosynthesis pathway","",1957.3,1900.4,1925.8,1788.5,1679.7,2416.4,0.9828195629269617,-0.025001520198253562,0.8906826228269447,0.05027702066508048,0.9262947197271113,0.0332508116043649,7028]
["Q9BU61-1","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [OS=Homo sapiens]",38,5,23,5,184,20.3,8.22,88.46,"cell organization and biogenesis","other membranes;mitochondrion;nucleus","","NDUFAF3","ENSG00000178057","Thermogenesis","Complex I biogenesis","",1924.6,1890.6,1815.1,2008,1792.1,2170.4,0.9430198475839543,-0.08463995950171507,0.37709676251595264,0.423547196121276,0.5654904056686701,0.24757475908600846,4874]
["Q9BUE0","Mediator of RNA polymerase II transcription subunit 18 [OS=Homo sapiens]",15,2,3,2,208,23.6,6.54,5.4,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","MED18","ENSG00000130772; ENSG00000284944","","Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression","",149.6,176.1,160.9,148.7,183.5,211.9,0.8943208968939533,-0.16113550812142138,0.3883428949370445,0.41078463622301087,0.5724885476189709,0.24223319677084057,4958]
["Q9BUL5-1","PHD finger protein 23 [OS=Homo sapiens]",5,2,3,2,403,43.8,5.78,6.47,"other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","PHF23","ENSG00000040633; ENSGGOG00000005820; ENSPPAG00000042657","","","",193.6,198,210.5,250.6,258.1,1019.8,0.3939156035328754,-1.344041529690559,0.2928979802899499,0.5332836230331641,0.5231650385970782,0.2813612861893137,4092]
["Q9BUR5-1","MICOS complex subunit MIC26 [OS=Homo sapiens]",32,5,14,5,198,22.3,9.13,45.62,"cell organization and biogenesis;transport","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi","","APOO","ENSG00000184831; ENSGGOG00000001200; ENSNLEG00000010026; ENSPPYG00000020191","","Cristae formation","",1676.8,1720.7,1700.9,1416.8,1550.8,1104.2,1.252124367601552,0.3243778654742183,0.061687870444620416,1.2098002219770247,0.2695018799042024,0.5694382010554462,1673]
["Q9BV23","Monoacylglycerol lipase ABHD6 [OS=Homo sapiens]",11,3,3,3,337,38.3,8.41,9.05,"other metabolic processes;other biological processes","plasma membrane;other membranes;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","ABHD6","ENSG00000163686","Retrograde endocannabinoid signaling","Arachidonate production from DAG","",139.5,134.3,137.3,136.4,143.4,1496,0.2315012951908999,-2.1109078298672452,0.3711936102212934,0.4303995083947643,0.5627575393294821,0.24967867799379828,4821]
["Q9BV44","THUMP domain-containing protein 3 [OS=Homo sapiens]",9,6,15,6,507,57,6.37,44.86,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","THUMPD3","ENSG00000134077","","","",2108.2,2090.5,2071.6,1995.8,2124.5,704.2,1.2996787231837494,0.37815503728963856,0.3479431224267829,0.4584917435104432,0.5529715768248219,0.25729719120050787,4599]
["Q9BV94-1","ER degradation-enhancing alpha-mannosidase-like protein 2 [OS=Homo sapiens]",5,3,7,3,578,64.7,5.31,14.41,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi","other molecular function","EDEM2","ENSG00000088298","Protein processing in endoplasmic reticulum","ER Quality Control Compartment (ERQC); Maturation of spike protein","",847.4,836.2,782.2,834.8,856.2,783.5,0.9964841382097394,-0.005081254106296933,0.9264260794074184,0.03318922781427177,0.9512852225890448,0.021689249598125914,7118]
["Q9BVI4","Nucleolar complex protein 4 homolog [OS=Homo sapiens]",24,8,15,8,516,58.4,7.49,51.37,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","","NOC4L","ENSG00000184967; ENSG00000288146","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",1203.2,1216.8,1124,1930.9,1897.3,2223.6,0.5856108926269871,-0.7719857062367441,1.4790442382985728E-3,2.83001883603581,0.04341499734025811,1.3623602212475732,249]
["Q9BVK2-1","Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase [OS=Homo sapiens]",5,2,4,2,526,60,9.14,10.37,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","ALG8","ENSG00000159063","N-Glycan biosynthesis; Metabolic pathways","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG8 causes CDG-1h","",200.7,204.6,210.3,167.4,203.1,220.2,1.0421533773489078,0.05956761970549996,0.6271756503514534,0.2026108111706831,0.7371003100850254,0.13247340610023342,6219]
["Q9BVQ7-1","Spermatogenesis-associated protein 5-like protein 1 [OS=Homo sapiens]",29,11,17,11,753,80.7,8.09,54.08,"","cytoskeleton;other cell component","other molecular function","SPATA5L1","ENSG00000171763","","","",425,379.5,415.4,359,392.2,674.2,0.8558299424722885,-0.22460394022999922,0.5346413304409668,0.2719374711525595,0.6721179023379819,0.17255453670299553,5814]
["Q9BW60","Elongation of very long chain fatty acids protein 1 [OS=Homo sapiens]",4,1,1,1,279,32.6,9.6,2.12,"other metabolic processes;developmental processes","other membranes;ER/Golgi","other molecular function","ELOVL1","ENSG00000066322","Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism","Synthesis of very long-chain fatty acyl-CoAs; alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism","Omega-9 fatty acid synthesis",76.1,83.2,89,79.3,78,98.5,0.9706802189210321,-0.04293200270479612,0.758848347719389,0.1198450071470489,0.8353046044399118,0.0781551246310934,6640]
["Q9BW62","katanin p60 ATPase-containing subunit A-like 1 [OS=Homo sapiens]",8,3,4,2,490,55.4,6.74,11.03,"cell organization and biogenesis;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KATNAL1","ENSG00000102781","","","",96.2,69.1,72.3,92.9,85,94.5,0.8722466960352423,-0.19719186721130538,0.2687398461923845,0.570667935730937,0.505330469724759,0.2964245144782304,3887]
["Q9BWF3-1","RNA-binding protein 4 [OS=Homo sapiens]",46,15,44,15,364,40.3,7.08,116.4,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RBM14; RBM4","ENSCATG00000036313; ENSG00000173933; ENSGGOG00000014455; ENSMFAG00000052468; ENSMLEG00000024601; ENSMMUG00000020363; ENSMNEG00000014872; ENSNLEG00000035021; ENSPPAG00000033403; ENSPTRG00000003934; ENSRBIG00000043267; ENSRROG00000044302","","Circadian Clock","",6454.7,6291,6374.3,4341.3,4349.3,4171,1.486595757915034,0.572012396323024,9.9003615411770335E-6,5.004348945556876,0.006578340227678448,2.1818836688311274,11]
["Q9BWL3","Uncharacterized protein C1orf43 [OS=Homo sapiens]",9,2,2,2,253,28.8,9.6,6.68,"transport","other membranes;mitochondrion;ER/Golgi","","C1orf43","ENSG00000143612","","","",190.5,169.4,182.1,240.2,253.2,247,0.7320367368989735,-0.4500120436293402,7.7643253568632838E-4,3.1098962741943144,0.032803152620412564,1.4840844154391368,173]
["Q9BX10","GTP-binding protein 2 [OS=Homo sapiens]",2,1,1,1,602,65.7,8.05,1.96,"protein metabolism;other metabolic processes","non-structural extracellular;other cell component","nucleic acid binding activity;other molecular function","GTPBP2","ENSG00000172432","","Platelet degranulation","Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway",62.6,58.6,54,110.4,82.2,156.9,0.5012875536480687,-0.9962896806616255,0.05694872609472864,1.244515986356043,0.2595001490189349,0.5858623884202149,1604]
["Q9BXB4","Oxysterol-binding protein-related protein 11 [OS=Homo sapiens]",28,15,32,15,747,83.6,7.06,106.32,"transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","OSBPL11","ENSG00000144909","","RHOH GTPase cycle","",2626,2573.1,2574.8,2844.2,2722.2,2097.5,1.014353005649865,0.020559812965355202,0.8820352924410112,0.054514037310654316,0.92031348357621,0.036064215048474735,7005]
["Q9BXF6","Rab11 family-interacting protein 5 [OS=Homo sapiens]",13,7,11,7,653,70.4,9.23,33.04,"cell-cell signaling;transport;other biological processes","other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB11FIP5","ENSG00000135631","Endocytosis","","",1080.5,1044.6,1071.7,1218.1,1257.4,1959.7,0.720779220779221,-0.47237067434479507,0.16211174409439957,0.7901855217915802,0.4138577497680637,0.38314890792920586,2863]
["Q9BXL7","Caspase recruitment domain-containing protein 11 [OS=Homo sapiens]",14,13,15,13,1154,133.2,6.09,42.42,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","kinase activity;other molecular function","CARD11","ENSG00000198286","NF-kappa B signaling pathway; T cell receptor signaling pathway; B cell receptor signaling pathway","FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; Activation of NF-kappaB in B cells","B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Modulators of TCR signaling and T cell activation; T-cell receptor (TCR) signaling pathway",1040.6,1072.9,1083.8,1108,1116.3,1391.9,0.8841601681322935,-0.17762035328075892,0.2123087496759868,0.6730321073050474,0.4595098168142694,0.33770520605648596,3377]
["Q9BXS9-1","Solute carrier family 26 member 6 [OS=Homo sapiens]",3,3,5,3,759,82.9,8.37,11.45,"stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component","transporter activity;other molecular function","SLC26A6","ENSG00000225697","Mineral absorption; Chemical carcinogenesis","Multifunctional anion exchangers","Proximal tubule transport",934.7,943.3,981.4,850.8,873.7,1081.8,1.0189217118625948,0.027043207297108858,0.8247257842907765,0.08369042740830719,0.8832118325833386,0.053935121237127834,6825]
["Q9BY12","S phase cyclin A-associated protein in the endoplasmic reticulum [OS=Homo sapiens]",5,6,9,6,1400,158.2,7.44,19.34,"","cytosol;ER/Golgi;nucleus","nucleic acid binding activity;other molecular function","SCAPER","ENSG00000140386","","","",649.4,655.5,616.2,725.9,802,707.4,0.8594372120073368,-0.21853585045390564,0.02900690602717722,1.5374985920171582,0.19326479138800212,0.7138472577078963,1097]
["Q9BY43","Charged multivesicular body protein 4a [OS=Homo sapiens]",31,6,11,6,222,25.1,4.7,34.79,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","CHMP4A","ENSG00000254505; ENSG00000285302","Endocytosis; Necroptosis","HCMV Late Events; Late endosomal microautophagy; Pyroptosis; Sealing of the nuclear envelope (NE) by ESCRT-III; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","",1304,1525,1174.1,1582,2041.1,2224.5,0.6845714481154661,-0.5467269727429674,0.04706205629800993,1.3273291009728183,0.23608549724238473,0.6269306908588355,1457]
["Q9BY50","Signal peptidase complex catalytic subunit SEC11C [OS=Homo sapiens]",33,7,57,7,192,21.5,9.2,140.87,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","SEC11C","ENSG00000166562","Protein export","SRP-dependent cotranslational protein targeting to membrane; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP); Synthesis, secretion, and deacylation of Ghrelin","",7800.3,8031.8,7612.4,7946.7,7965.9,9867.3,0.9094100442592873,-0.13699715642725532,0.29618776398245394,0.5284328868839024,0.5245544867816224,0.2802093938773455,4127]
["Q9BYD3","39S ribosomal protein L4, mitochondrial [OS=Homo sapiens]",40,8,16,8,311,34.9,9.72,64.08,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL4","ENSG00000105364","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1712,1703.4,1764.5,1558.3,1496.3,1885.4,1.0485627530364372,0.06841320457742259,0.5485833490585126,0.2607573785064648,0.682600561503008,0.16583335880927325,5874]
["Q9BYT3-1","Serine/threonine-protein kinase 33 [OS=Homo sapiens]",20,8,10,8,514,57.8,7.03,25.81,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction","nucleus;other cell component","kinase activity;other molecular function","STK33","ENSG00000130413","","","",718.4,692.5,706.8,643.6,667.5,778.5,1.013447549770291,0.019271425120179243,0.8353306959462414,0.07814155925602706,0.88948602224229,0.05086087221270313,6864]
["Q9BYV9","Transcription regulator protein BACH2 [OS=Homo sapiens]",2,1,1,1,841,92.5,5.1,2.39,"transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","BACH2","ENSG00000112182","","","",83.7,71.5,95,90.4,78.5,180.7,0.7156750572082379,-0.4826233953347788,0.3718116487231354,0.42967700806350123,0.5631105139903433,0.24940636375229525,4826]
["Q9BZ95","Histone-lysine N-methyltransferase NSD3 [OS=Homo sapiens]",4,4,5,1,1437,161.5,8.21,15.42,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","NSD3","ENSG00000147548","Lysine degradation; Metabolic pathways","PKMTs methylate histone lysines","",197.5,197.3,179.9,204.1,236.1,369.5,0.7097690502655305,-0.4945784283525988,0.19924283606309254,0.7006172850595833,0.44684439668154136,0.3498436836407545,3259]
["Q9BZF1-1","Oxysterol-binding protein-related protein 8 [OS=Homo sapiens]",33,24,60,22,889,101.1,6.96,152,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","OSBPL8","ENSG00000091039; ENSPTRG00000005242","","Acyl chain remodelling of PS","",5622.8,5820.3,5779.2,5497.1,5783,5543.6,1.0236927667516658,0.03378279503434887,0.2824549994101837,0.5490507339138804,0.5156002973748832,0.2876868408371885,4004]
["Q9BZF2","Oxysterol-binding protein-related protein 7 [OS=Homo sapiens]",6,4,6,4,842,95.4,8.05,24.38,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","OSBPL7","ENSG00000006025","","Synthesis of bile acids and bile salts","",384.2,406,370.2,367.7,397.5,401.4,0.9946854105948912,-0.007687778615767359,0.8963318808503706,0.04753115625892706,0.9305809257294544,0.03124585351706631,7040]
["Q9BZL4","Protein phosphatase 1 regulatory subunit 12C [OS=Homo sapiens]",36,18,25,1,782,84.8,5.57,76.28,"signal transduction;other biological processes","cytoskeleton;other cell component","enzyme regulator activity;other molecular function","PPP1R12C","ENSG00000125503","Vascular smooth muscle contraction; Focal adhesion; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Proteoglycans in cancer","","Focal adhesion",21.9,17.2,29.5,15.1,18.4,34.7,1.005865102639296,0.008436837148639532,0.9857946944725318,0.006213523539281562,0.9905380013609754,4.1288583740016985E-3,7274]
["Q9BZQ6","ER degradation-enhancing alpha-mannosidase-like protein 3 [OS=Homo sapiens]",16,11,22,11,932,104.6,4.93,67.01,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","other molecular function","EDEM3","ENSG00000116406","Protein processing in endoplasmic reticulum","ER Quality Control Compartment (ERQC)","",1574,1516.6,1578.1,2068,2034.8,1794.4,0.7916807976666892,-0.33700923585646436,0.009812063940589859,2.008239630364259,0.11383551641550997,0.9437222179338678,630]
["Q9C037-1","E3 ubiquitin-protein ligase TRIM4 [OS=Homo sapiens]",22,9,14,9,500,57.4,8.1,44.58,"protein metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","TRIM4","ENSG00000146833","","Antigen processing: Ubiquitination & Proteasome degradation; Negative regulators of DDX58/IFIH1 signaling; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; TRAF6 mediated IRF7 activation; TRAF6 mediated NF-kB activation; Ovarian tumor domain proteases; TRAF3-dependent IRF activation pathway","",1202,1185.8,1198.4,1044.8,994.2,1105.9,1.1403224267862255,0.18944180487836648,0.010793941993034626,1.966819920175999,0.11971611840226112,0.921847372886036,659]
["Q9C0C9","(E3-independent) E2 ubiquitin-conjugating enzyme [OS=Homo sapiens]",34,34,79,34,1292,141.2,5.12,264.41,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","UBE2O","ENSG00000175931","Ubiquitin mediated proteolysis","Antigen processing: Ubiquitination & Proteasome degradation","",7308.9,7458.2,7501.1,7722.8,7565.1,7149.7,0.9924501729240202,-0.010933422938999581,0.7701315083862552,0.11343510795760806,0.8430269873888182,0.07415852230711772,6677]
["Q9C0J8","pre-mRNA 3' end processing protein WDR33 [OS=Homo sapiens]",23,22,38,22,1336,145.8,9.17,83.97,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","","WDR33","ENSG00000136709","mRNA surveillance pathway","mRNA Splicing - Major Pathway; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs","",2482.7,2508.9,2575.9,2987.3,3005.9,3473.9,0.7993472129796875,-0.32310579118947386,0.017269092836807012,1.7627304757687716,0.15188904878967804,0.8184735376689097,831]
["Q9GZM5","protein YIPF3 [OS=Homo sapiens]",13,3,4,3,350,38.2,5.76,17.57,"other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","","YIPF3","ENSG00000137207","","","",526.7,518.9,531.5,573.9,549.6,590.7,0.9200210010500525,-0.1202613013644961,0.02155829017198238,1.6663856868210845,0.16942961598604217,0.7710106734910466,930]
["Q9GZS1-2","Isoform 2 of DNA-directed RNA polymerase I subunit RPA49 [OS=Homo sapiens]",32,10,21,10,419,47.2,8.94,68.24,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","POLR1E","ENSG00000137054","RNA polymerase","B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","Pyrimidine metabolism; Eukaryotic transcription initiation; Eukaryotic transcription initiation",2047.7,1968.5,1888.8,2302.3,2165.1,1466.7,0.9950961392629043,-0.007092179344126956,0.9723200712878186,0.012190749155487315,0.9821292704591855,0.007831345459290475,7236]
["Q9GZT6","Coiled-coil domain-containing protein 90B, mitochondrial [OS=Homo sapiens]",28,8,18,8,254,29.5,7.55,45.98,"","other membranes;mitochondrion","","CCDC90B","ENSG00000137500","","","",1827.5,1849.9,1879.2,1435.1,1775.7,1504,1.178544158819038,0.23700581587759423,0.055730128182653986,1.2539099580391653,0.2561833376647912,0.5914491204756438,1590]
["Q9GZU8","Protein FAM192A [OS=Homo sapiens]",33,7,10,7,254,28.9,5.45,17.77,"other biological processes","nucleus","","PSME3IP1","ENSG00000172775","","","",791,756.8,1196.3,1528.8,1237.5,856.1,0.7575364399293285,-0.4006128063798219,0.2904485624388636,0.5369307687020027,0.5217224239040683,0.28256049667131494,4069]
["Q9GZY8-2","Isoform 2 of Mitochondrial fission factor [OS=Homo sapiens]",40,8,15,4,291,33,7.44,59.29,"","","","MFF","","","","",785.6,791.6,817.3,885.2,839.7,650.1,1.0082105263157894,0.011796922130328527,0.9330046951034616,0.0301161707739772,0.9556237831433858,0.01971305025807088,7136]
["Q9H078-2","Isoform 2 of Caseinolytic peptidase B protein homolog [OS=Homo sapiens]",32,20,53,20,677,75.4,9.01,157.62,"","","","CLPB","","","","",5074.7,4987.1,5063.1,4931.5,4727,4304.6,1.0832050189427849,0.11530632865173955,0.10659386539994746,0.9722677887392269,0.34519032441657777,0.4619413859330159,2257]
["Q9H0D6-1","5'-3' exoribonuclease 2 [OS=Homo sapiens]",43,33,111,33,950,108.5,7.47,358.53,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","XRN2","ENSG00000088930","Ribosome biogenesis in eukaryotes; RNA degradation","Major pathway of rRNA processing in the nucleolus and cytosol; Association of TriC/CCT with target proteins during biosynthesis","mRNA processing",10546.2,10503.6,10579.6,10274.4,11030.1,12195,0.9441752861983015,-0.08287337401469591,0.32729465320895634,0.4850610894088096,0.5399992370889982,0.26760685374790616,4430]
["Q9H0H0","integrator complex subunit 2 [OS=Homo sapiens]",9,7,9,7,1204,134.2,6.05,30.57,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","","INTS2","ENSG00000108506","","RNA polymerase II transcribes snRNA genes","",704.3,686.4,684.6,753.6,728.6,945.9,0.8547012067048307,-0.2265079356425652,0.16320974450609696,0.7872539150742652,0.41549983371475535,0.3814291456867983,2871]
["Q9H0K6","Pseudouridylate synthase 7 homolog-like protein [OS=Homo sapiens]",9,5,10,5,701,80.6,7.56,31.67,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","PUS7L","ENSG00000129317","","","",743.8,739.6,777,896.2,977.3,1128.3,0.7530148577520155,-0.4092497638630927,0.023163624159909364,1.6351934903023675,0.17562544500495594,0.7554125623212253,964]
["Q9H0U3","Magnesium transporter protein 1 [OS=Homo sapiens]",17,8,25,8,335,38,9.63,56.67,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","transporter activity","MAGT1","ENSG00000102158","","Neutrophil degranulation; Maturation of spike protein; Miscellaneous transport and binding events; Asparagine N-linked glycosylation","",2680.6,2697.9,2741.8,2494.9,2499.4,4648,{"$f":"AVERAGE(S5890:U5890)/AVERAGE(V5890:X5890)","v":0.8421538429627787},{"$f":"LOG(Y5890,2)","v":-0.2478442889048453},{"$f":"TTEST(S5890:U5890,V5890:X5890,2,2)","v":0.5183559461717092},{"$f":"-LOG10(AA5890)","v":0.2853719152152331},{"$f":"AA5890*7309/AE5890","v":0.6598160241325361},{"$f":"-LOG10(AC5890)","v":0.18057714149174733},5742]
["Q9H0U4","ras-related protein Rab-1B [OS=Homo sapiens]",83,15,110,6,201,22.2,5.73,318.85,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","RAB1B","ENSG00000174903","Legionellosis","COPI-mediated anterograde transport; COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs; COPI-dependent Golgi-to-ER retrograde traffic; RAB geranylgeranylation; Golgi Cisternae Pericentriolar Stack Reorganization","",5089.5,5651.9,5413.1,4986.7,5698.4,5384,1.0053145477967032,0.0076469696091441,0.918895744926075,0.03673375952981487,0.9466115573875521,0.0238281974393347,7095]
["Q9H115","Beta-soluble NSF attachment protein [OS=Homo sapiens]",35,8,33,5,298,33.5,5.47,97.76,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","other membranes;other cytoplasmic organelle;other cell component","other molecular function","NAPB","ENSG00000125814","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Retrograde transport at the Trans-Golgi-Network; Intra-Golgi traffic; COPII-mediated vesicle transport","",501.4,510.7,503.4,523.8,508.8,368.9,1.0813414199072422,0.11282210775183509,0.4847001708169926,0.3145268272240857,0.6352292538105432,0.19706950983167373,5577]
["Q9H1A4","anaphase-promoting complex subunit 1 [OS=Homo sapiens]",7,9,20,9,1944,216.4,6.3,56.12,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","ANAPC1","ENSG00000153107","Cell cycle; Oocyte meiosis; Ubiquitin mediated proteolysis; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection","Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Cyclin B; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Inactivation of APC/C via direct inhibition of the APC/C complex; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Cell cycle",1237.7,1259.3,1237.7,1327.7,1224.9,1026.8,1.0433871598591942,0.06127458448035736,0.5903834392150559,0.22886583336386124,0.7101896901288418,0.14862563667063708,6076]
["Q9H1C4","Protein unc-93 homolog B1 [OS=Homo sapiens]",12,6,36,6,597,66.6,6.96,84.38,"stress response;transport;signal transduction;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding","UNC93B1","ENSG00000110057","","Trafficking and processing of endosomal TLR; UNC93B1 deficiency - HSE","",2695.6,2857,2756,3008.8,2941.4,2004,1.0445550778205224,0.06288856555349166,0.7366972940257512,0.13271092535597878,0.8193123131518892,0.08655051823502992,6572]
["Q9H1K1","Iron-sulfur cluster assembly enzyme ISCU, mitochondrial [OS=Homo sapiens]",20,4,6,4,167,18,9.48,17.48,"cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","ISCU","ENSG00000136003","","","",863.4,829.8,767,790.5,885.1,428.7,1.1691298769186904,0.22543520564258174,0.45021147723787436,0.34658343772834455,0.6106134138303254,0.214233659440397,5389]
["Q9H246","Uncharacterized protein C1orf21 [OS=Homo sapiens]",11,1,1,1,121,13.9,5.22,4.29,"","","","C1orf21","ENSG00000116667","","","",69.2,75.3,67.1,68.1,80.8,43.2,1.1015096304008332,0.13948210844849898,0.5963727809745349,0.22448218638322934,0.7136359947843609,0.1465232528836399,6108]
["Q9H269","Vacuolar protein sorting-associated protein 16 homolog [OS=Homo sapiens]",18,12,37,12,839,94.6,6.77,104.51,"cell organization and biogenesis;other metabolic processes;transport","other membranes;other cytoplasmic organelle;other cell component","cytoskeletal activity","VPS16","ENSG00000215305","Salmonella infection","","Ebola virus pathway in host; Network map of SARS-CoV-2 signaling pathway",3180.8,3189.1,3288.4,3141.1,3008.9,3178,1.0354095197255573,0.05020148774813568,0.1498511597118065,0.8243398916606839,0.40281799423817344,0.3948911373642111,2719]
["Q9H2G9-1","Golgin-45 [OS=Homo sapiens]",3,1,1,1,400,44.9,8.54,2.25,"cell organization and biogenesis;transport","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","BLZF1","ENSG00000117475","","Golgi Cisternae Pericentriolar Stack Reorganization","",62,65.4,54.1,102.7,107.5,61.2,0.6687546057479735,-0.580451172535741,0.11774249992897295,0.9290667474109563,0.3612846062052323,0.44215054267374204,2382]
["Q9H2H8-1","peptidyl-prolyl cis-trans isomerase-like 3 [OS=Homo sapiens]",39,7,18,7,161,18.1,6.79,51.85,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","CLK1; LOC111141199; PPIL3","ENSAMEG00000005917; ENSCAFG00000011929; ENSECAG00000019985; ENSFCAG00000005373; ENSG00000240344; ENSGGOG00000022268; ENSOCUG00000010661; ENSPPAG00000039183; ENSPPYG00000013062; ENSPTRG00000012793; ENSRFEG00010017851; ENSSSCG00000016096; ENSSSCG00070023158; ENSSSUG00005004462; ENSSTOG00000028255; ENSUMAG00000021460","","mRNA Splicing - Major Pathway; mRNA Splicing - Major Pathway","mRNA Processing",1287.4,1371.2,1365.7,1325.5,1363.2,1218.6,1.0299439510659536,0.04256582894308232,0.4876073257032319,0.31192977826163276,0.6375531204946193,0.19548362426408306,5590]
["Q9H2P9-1","Diphthine methyl ester synthase [OS=Homo sapiens]",15,4,8,4,285,31.6,5.31,21.24,"protein metabolism;other metabolic processes","cytosol","other molecular function","DPH5","ENSG00000117543; ENSPPAG00000030165; ENSPTRG00000001012","","Synthesis of diphthamide-EEF2","",1181.2,1138.1,1167.4,1197.2,1096.9,675.4,1.17417073581411,0.23164220555427933,0.34287686344625384,0.4648618191038524,0.5506673247481145,0.25911069272627235,4551]
["Q9H329","Band 4.1-like protein 4B [OS=Homo sapiens]",1,1,2,1,900,99.7,9.04,2.25,"cell organization and biogenesis;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity","EPB41L4B","ENSG00000095203","Tight junction","","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway",152.8,172.1,161.6,167.3,146,167.2,1.012486992715921,0.01790337400736127,0.8353201693227597,0.07814703215833874,0.8896044175404415,0.050803069165037185,6863]
["Q9H3E2","Sorting nexin-25 [OS=Homo sapiens]",3,3,4,3,840,97.9,6.38,7.29,"other metabolic processes;transport;other biological processes","other membranes;other cytoplasmic organelle;other cell component","other molecular function","SNX25","ENSG00000109762","","","",385.9,402.7,389.2,407.3,419.9,337.7,1.0110739119237702,0.015888465557693354,0.8769983705454563,0.05700121354818328,0.9168904434725704,0.03768255379321822,6991]
["Q9H3P2-1","Negative elongation factor A [OS=Homo sapiens]",38,14,42,14,528,57.2,9.03,144.18,"developmental processes;other biological processes","cytosol;nucleus","other molecular function","NELFA","ENSG00000185049","","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat","Initiation of transcription and translation elongation at the HIV-1 LTR",3268.5,3160.3,3158.7,4012.5,4100.4,4799.8,0.7424860795960566,-0.42956411690122615,0.011660467794214906,1.9332840262175748,0.12441804249330912,0.9051166358260273,685]
["Q9H3S7","Tyrosine-protein phosphatase non-receptor type 23 [OS=Homo sapiens]",20,27,56,27,1636,178.9,6.92,172.73,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PTPN23","ENSG00000076201","","Interleukin-37 signaling","",5931.2,5858.8,5743,5749.2,5574.5,7359.2,0.9384517392910092,-0.09164553978941853,0.5385898646072175,0.26874182356946563,0.6747605965742463,0.17085028647120654,5834]
["Q9H3Z4","DnaJ homolog subfamily C member 5 [OS=Homo sapiens]",32,5,14,5,198,22.1,5.07,43.26,"cell-cell signaling;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","DNAJC5","ENSG00000101152","Protein processing in endoplasmic reticulum","Neutrophil degranulation; Sensory processing of sound by inner hair cells of the cochlea; GABA synthesis, release, reuptake and degradation","",2008.2,2027.4,2107.2,1614.8,1876,979.2,1.374228187919463,0.45862158075449483,0.10596762229489773,0.9748268102695375,0.3440770108189283,0.4633443433860846,2251]
["Q9H488-1","GDP-fucose protein O-fucosyltransferase 1 [OS=Homo sapiens]",9,2,8,2,388,43.9,8.53,26.45,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","POFUT1","ENSG00000101346; ENSPTRG00000013375","Other types of O-glycan biosynthesis","Pre-NOTCH Processing in the Endoplasmic Reticulum","Delta-Notch signaling pathway",391.5,376,346.2,391.9,368.3,277,1.0737562668723486,0.10266655153535716,0.5335365581778844,0.27283581715617317,0.6715375759810843,0.1729296813055244,5807]
["Q9H490","Phosphatidylinositol glycan anchor biosynthesis class U protein [OS=Homo sapiens]",11,4,7,4,435,50,7.72,24.74,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;ER/Golgi","","PIGU","ENSG00000101464","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways","Attachment of GPI anchor to uPAR","",963.5,970.6,1025,852,868.4,995.1,1.0897072362364206,0.12394058861488308,0.17428193122207655,0.7587476362825069,0.4258865380481971,0.37070608742985206,2991]
["Q9H4G0-1","Band 4.1-like protein 1 [OS=Homo sapiens]",39,26,63,4,881,98.4,5.62,181.92,"cell organization and biogenesis","plasma membrane;other membranes;cytosol;cytoskeleton","cytoskeletal activity;other molecular function","EPB41L1","ENSG00000088367","","Neurexins and neuroligins; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Trafficking of AMPA receptors","Splicing factor NOVA regulated synaptic proteins",5563.8,5521.6,5612.5,5075.6,4925,4842.4,1.1249679983830763,0.1698839621261331,1.0729967862564936E-3,2.9694015787918877,0.03647690004999401,1.4379820768235203,215]
["Q9H4K7","Mitochondrial ribosome-associated GTPase 2 [OS=Homo sapiens]",9,2,2,2,406,43.9,9.45,8.88,"other biological processes","other membranes;mitochondrion;translational apparatus","other molecular function","MTG2","ENSG00000101181","","","",51.6,54.9,55.1,60,63.9,79.5,0.7944936086529008,-0.33189248110570524,0.08316420824101245,1.08006354279404,0.3125178396059434,0.5051251865717935,1945]
["Q9H4L7","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 [OS=Homo sapiens]",6,5,11,5,1026,117.3,5.55,27.98,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SMARCAD1","ENSG00000163104","Signaling pathways regulating pluripotency of stem cells","","",754,775.8,759.1,1003.2,946.8,655.6,0.8784540988639853,-0.18696119063592379,0.38330719112365147,0.4164530329866475,0.568735740950623,0.24508947860575891,4926]
["Q9H583","HEAT repeat-containing protein 1 [OS=Homo sapiens]",15,31,81,31,2144,242.2,6.54,202.7,"RNA metabolism OR transcription;other metabolic processes;other biological processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity","HEATR1","ENSG00000119285","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",7025.8,6990.2,6864.1,8149,7697.9,6891.1,0.9182909666637347,-0.1229767411923317,0.17055561369974404,0.7681339815705736,0.42243001712349343,0.3742452291865601,2951]
["Q9H5X1-1","MIP18 family protein FAM96A [OS=Homo sapiens]",28,4,10,4,160,18.3,4.88,28.37,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","CIAO2A","ENSCANG00000036332; ENSCATG00000033389; ENSG00000166797; ENSGGOG00000016550; ENSMFAG00000035924; ENSMLEG00000042755; ENSMMUG00000014004; ENSPANG00000016877; ENSPPAG00000026013; ENSPTRG00000007153; ENSRBIG00000030155; ENSRROG00000031571","","","",629.5,657.4,637.6,663.9,698.2,1075.6,0.7894736842105263,-0.34103691783506696,0.2651665221287063,0.5764813074638593,0.5024895281925627,0.29887298444592825,3857]
["Q9H6A0-1","DENN domain-containing protein 2D [OS=Homo sapiens]",5,2,3,2,471,53.6,7.64,9.16,"","cytosol;nucleus","enzyme regulator activity","DENND2D","ENSG00000162777; ENSPPAG00000037282","","RAB GEFs exchange GTP for GDP on RABs","",109.1,101.7,110.5,116.3,116.6,260.3,0.6514598540145986,-0.6182518189314269,0.2987735115479624,0.5246579085249334,0.5255681337915901,0.27937097476109035,4155]
["Q9H6K1","Uncharacterized protein C6orf106 [OS=Homo sapiens]",7,1,2,1,298,32.9,4.58,4.76,"other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","ILRUN","ENSG00000196821","","","",196,192.7,182.3,207.4,240.5,224.8,0.8488181953322432,-0.23647251258114932,0.031208074782001702,1.5057330220217018,0.1993879533056385,0.7003010845947342,1144]
["Q9H6P5","Threonine aspartase 1 [OS=Homo sapiens]",12,3,3,3,420,44.4,7.75,6.42,"protein metabolism;other metabolic processes;other biological processes","other cell component","other molecular function","TASP1","ENSG00000089123","","","",159.6,164.4,149.5,142.6,141.7,177.4,1.0255577214641545,0.03640869330638131,0.7695654660885886,0.11375442930661467,0.8425335517737408,0.07441279542985083,6676]
["Q9H6U8","Alpha-1,2-mannosyltransferase ALG9 [OS=Homo sapiens]",6,3,6,3,611,69.8,8.68,22.32,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","ALG9","ENSG00000086848","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG9 causes CDG-1l","",526.1,603.6,573.3,510.2,559.4,731.2,0.9456908040870724,-0.0805595268882509,0.6686082116581742,0.17482829382790702,0.7686155110112607,0.11429085552268811,6358]
["Q9H788","SH2 domain-containing protein 4A [OS=Homo sapiens]",22,8,14,8,454,52.7,8.06,29.96,"other biological processes","cytosol;other cell component","other molecular function","SH2D4A","ENSG00000104611","","","",1464.4,1417.3,1440.1,1698.6,1802.6,2046,0.7790957600230746,-0.36012743153010485,0.017048970696944457,1.7683018356821003,0.15067826701809797,0.8219493833506741,827]
["Q9H7B4-1","Histone-lysine N-methyltransferase SMYD3 [OS=Homo sapiens]",7,2,9,2,428,49.1,7.25,19.06,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","SMYD3","ENSG00000185420","Lysine degradation; Metabolic pathways","PKMTs methylate histone lysines","Histone modifications",381.1,356.2,348.9,385.1,294.4,389.4,1.0161848629432124,0.023162879069744863,0.8676775215657674,0.06164165342568666,0.9100093277549424,0.04095415606161162,6969]
["Q9H7P6","Multivesicular body subunit 12B [OS=Homo sapiens]",7,1,1,1,319,35.6,8.15,4.5,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MVB12B","ENSG00000196814","Endocytosis","Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Late endosomal microautophagy","",42.4,40.7,55.2,44.7,30.3,24.9,1.3843843843843842,0.46924457335807557,0.16195393827078536,0.7906084866876145,0.41359934829530753,0.3834201542273991,2862]
["Q9H832","Ubiquitin-conjugating enzyme E2 Z [OS=Homo sapiens]",21,7,11,7,354,38.2,5.62,28.13,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","enzyme regulator activity;other molecular function","UBE2Z","ENSG00000159202","Ubiquitin mediated proteolysis","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation","",2053.5,2008.8,2026.6,1933.4,1888.7,943.2,1.2777579585755354,0.35361457726001655,0.24388174398869242,0.6128207080163734,0.4847788052252795,0.31445637600126286,3677]
["Q9H871-1","Protein RMD5 homolog A [OS=Homo sapiens]",19,4,10,4,391,44,6.06,36.75,"protein metabolism;other metabolic processes","nucleus;other cell component","other molecular function","LOC111148095; RMD5A; Rmnd5a; RMND5A","ENSAMEG00000009979; ENSBIXG00000016128; ENSBIXG00005012781; ENSBMUG00000001433; ENSBTAG00000021140; ENSCANG00000000502; ENSCATG00000002310; ENSCHIG00000026499; ENSCPOG00000038199; ENSCSAG00000016355; ENSDLEG00000016828; ENSECAG00000020001; ENSG00000153561; ENSHGLG00000004880; ENSLCNG00005014561; ENSMFAG00000065825; ENSMMNG00015005282; ENSMMUG00000003523; ENSMNEG00000044699; ENSMPUG00000009296; ENSMUSG00000002222; ENSNVIG00000017991; ENSOARG00000020715; ENSOCUG00000009371; ENSOGAG00000007229; ENSPANG00000005829; ENSPCOG00000015308; ENSPCTG00005006099; ENSPPYG00000012209; ENSPTRG00000050213; ENSRBIG00000033920; ENSRNOG00000028422; ENSRROG00000038497; ENSSSCG00000035478; ENSSSCG00070028877; ENSSSUG00005017842","","","Ciliary landscape",429.9,413.4,413.2,376.5,427.2,314.8,1.1233795261510953,0.1678454148215367,0.2353903888066151,0.6282112737502996,0.4775099505377601,0.3210175739888952,3603]
["Q9H8M1","Coenzyme Q-binding protein COQ10 homolog B, mitochondrial [OS=Homo sapiens]",3,1,1,1,238,27.1,9.6,2.4,"other metabolic processes","other membranes;mitochondrion","other molecular function","COQ10B","ENSG00000115520","","Respiratory electron transport","",93.6,103,97.2,112.2,120.4,189.9,{"$f":"AVERAGE(S6082:U6082)/AVERAGE(V6082:X6082)","v":0.6953846153846154},{"$f":"LOG(Y6082,2)","v":-0.5241169455006293},{"$f":"TTEST(S6082:U6082,V6082:X6082,2,2)","v":0.15869828676141498},{"$f":"-LOG10(AA6082)","v":0.799427761676657},{"$f":"AA6082*7309/AE6082","v":0.41073858992180673},{"$f":"-LOG10(AC6082)","v":0.3864344921724501},2824]
["Q9H8T0-1","AKT-interacting protein [OS=Homo sapiens]",11,3,4,3,292,33.1,9.31,11.58,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","AKTIP; FTS","ENSCSAG00000005299; ENSG00000166971; ENSGGOG00000014821; ENSMNEG00000035738; ENSNLEG00000031116; ENSPANG00000018701; ENSPTRG00000008116; ENSRROG00000038050; ENSSBOG00000028267","","","",401.6,412.3,433.5,486.9,446.2,359.6,0.9649570666047809,-0.05146334025201248,0.7162125964265376,0.14495804508000834,0.8033759771764216,0.09508115883250713,6516]
["Q9H936","Mitochondrial glutamate carrier 1 [OS=Homo sapiens]",7,2,6,2,323,34.4,9.29,22.94,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","SLC25A22","ENSG00000177542","","Organic anion transporters","",1371.1,1287.3,1322.6,1191.8,1113.2,1792.1,0.9716628835029654,-0.04147223440907498,0.8663791714939709,0.0622919970729105,0.9093000236142208,0.04129279763423112,6964]
["Q9H999","Pantothenate kinase 3 [OS=Homo sapiens]",13,4,9,2,370,41.1,6.55,21.39,"other metabolic processes","cytosol;nucleus","kinase activity;other molecular function","PANK3","ENSG00000120137","Pantothenate and CoA biosynthesis; Metabolic pathways; Biosynthesis of cofactors","Coenzyme A biosynthesis","",46.1,50.3,42.5,71.6,68,60.3,0.694847423711856,-0.5252318727632349,0.00721200865450758,2.1419437607900917,0.09779697821112412,1.0096745640928575,539]
["Q9H9A7","RecQ-mediated genome instability protein 1 [OS=Homo sapiens]",7,3,3,3,625,70.1,4.96,10.08,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","nucleus;other cell component","other molecular function","RMI1","ENSG00000178966","Fanconi anemia pathway","Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function","",94.8,117.4,104.7,114.5,121,189,0.7465253239104829,-0.42173689405816733,0.22020284193762577,0.6571770803240118,0.4648938682039592,0.3326461819794138,3462]
["Q9H9J4-1","Ubiquitin carboxyl-terminal hydrolase 42 [OS=Homo sapiens]",2,2,2,2,1324,145.3,8.63,5.63,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","USP42","ENSG00000106346","","Ub-specific processing proteases","",46.1,53.9,57,63.8,67.5,198.3,0.47633495145631066,-1.069951683404229,0.26428966922805325,0.5779198125963905,0.5014779834859401,0.2997481291649144,3852]
["Q9H9T3","elongator complex protein 3 [OS=Homo sapiens]",20,10,24,10,547,62.2,8.88,76.04,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","ELP3","ENSG00000134014","","HATs acetylate histones","Ethanol effects on histone modifications",2415.7,2376.3,2389.6,2721.4,2688.5,2101,0.9561570517514546,-0.06468049009774335,0.6155055979864477,0.21076799283247274,0.7270087937432039,0.1384603359758297,6188]
["Q9HA64","Ketosamine-3-kinase [OS=Homo sapiens]",28,8,20,8,309,34.4,7.33,43.08,"protein metabolism;other metabolic processes","cytosol","kinase activity;other molecular function","FN3KRP","ENSG00000141560","","Gamma carboxylation, hypusine formation and arylsulfatase activation","",2270,2205.3,2207.2,2250.9,2219.8,3886.1,0.7996481906950028,-0.3225626763544545,0.3681968355272207,0.43391994836587683,0.5607732175179112,0.2512127364143253,4799]
["Q9HAF1","Chromatin modification-related protein MEAF6 [OS=Homo sapiens]",18,2,3,2,191,21.6,9.32,11.04,"protein metabolism;other metabolic processes","nucleus;other cell component","","MEAF6","ENSG00000163875","","HATs acetylate histones; Regulation of TP53 Activity through Acetylation","",32.6,31.1,32.8,31,43.9,80.8,0.619781631342325,-0.6901680969235942,0.2568314630379545,0.5903517742684172,0.4956908273948797,0.3047891175052706,3787]
["Q9HAP2-1","MLX-interacting protein [OS=Homo sapiens]",2,1,1,1,919,101.1,8.35,0,"other biological processes","other membranes;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","MLXIP","ENSG00000175727; ENSG00000281178","Insulin resistance; Non-alcoholic fatty liver disease","","Nonalcoholic fatty liver disease",18.3,16.6,16.7,22.4,16.8,27.4,0.774774774774775,-0.36815111164800773,0.18325852877464457,0.7369358043344585,0.43138054325728736,0.3651394469630844,3105]
["Q9HAW4","Claspin [OS=Homo sapiens]",1,1,1,1,1339,151,4.82,2.74,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","ER/Golgi;nucleus","nucleic acid binding activity;other molecular function","CLSPN","ENSG00000092853","","Ub-specific processing proteases; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Apoptotic cleavage of cellular proteins","",21.1,20,20.2,21.7,21,56.1,0.6204453441295545,-0.6886239678938965,0.34150175470802013,0.4666070604800982,0.5493037687413995,0.2601874212990876,4544]
["Q9HB90","ras-related GTP-binding protein C [OS=Homo sapiens]",34,9,14,5,399,44.2,5.1,41.02,"RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RRAGC","ENSG00000116954","Autophagy; mTOR signaling pathway; Shigellosis","Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Macroautophagy; mTORC1-mediated signalling; Amino acids regulate mTORC1; Energy dependent regulation of mTOR by LKB1-AMPK","Target of rapamycin (TOR) signaling",1464.1,1483.2,1544.2,1354.1,1175,810.3,1.3450020961849436,0.4276084212229897,0.07654427733585678,1.1160872728215223,0.3004630091556269,0.5222089875828732,1862]
["Q9HBH5","Retinol dehydrogenase 14 [OS=Homo sapiens]",34,9,27,9,336,36.8,8.79,85.2,"other metabolic processes","other membranes;cytosol;ER/Golgi;nucleus","other molecular function","RDH14","ENSG00000240857","","RA biosynthesis pathway","",2679.2,2671.2,2644.5,2603.7,2663.9,2761.4,0.9957528957528957,-0.006140324784702213,0.821272594225027,0.08551266928936439,0.8808043127205755,0.055120567576083815,6815]
["Q9HBR0","Putative sodium-coupled neutral amino acid transporter 10 [OS=Homo sapiens]",16,16,33,16,1119,119.7,5.73,90.23,"transport;developmental processes","other membranes;ER/Golgi","transporter activity","SLC38A10","ENSG00000157637","","","",3913.5,3975.8,3895.3,4051.9,4349.2,5987.7,0.8190120093405984,-0.2880434883335339,0.22299477434309645,0.6517053140843448,0.46714497153158263,0.3305483216484828,3489]
["Q9HC52","chromobox protein homolog 8 [OS=Homo sapiens]",22,7,17,7,389,43.4,9.91,39.61,"protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","CBX8","ENSG00000141570","","SUMOylation of DNA damage response and repair proteins; SUMOylation of RNA binding proteins; SUMOylation of chromatin organization proteins; SUMOylation of transcription cofactors; Oxidative Stress Induced Senescence; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN gene transcription","",1057.7,1038.2,1146.7,1282.9,1176.7,1419.3,0.8359586480703292,-0.2584965158579795,0.05255298843180081,1.2794025827273,0.250234392474288,0.6016530006565323,1535]
["Q9HCC9-1","Lateral signaling target protein 2 homolog [OS=Homo sapiens]",6,3,3,3,887,96.4,5.11,10.56,"other biological processes","other membranes;cytosol;other cytoplasmic organelle","other molecular function","ZFYVE28","ENSG00000159733","","","",54.3,38.6,53.8,53.8,46.8,81.2,0.8069306930693069,-0.3094833285207173,0.3736289833648937,0.4275594417909474,0.5638765722514987,0.2488159489535138,4843]
["Q9HCJ1","progressive ankylosis protein homolog [OS=Homo sapiens]",5,2,5,2,492,54.2,7.88,10.25,"transport;developmental processes;other biological processes","plasma membrane;other membranes","transporter activity","ANKH","ENSG00000154122","","Miscellaneous transport and binding events","",419.4,429.1,423.1,412.9,399.6,276.7,1.16746235769372,0.2233760340941798,0.23425343688862016,0.6303140285690508,0.47679152609828035,0.32167147181115097,3591]
["Q9HCK8-1","Chromodomain-helicase-dna-binding protein 8 [OS=Homo sapiens]",5,11,13,5,2581,290.3,6.47,32.73,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CHD8","ENSG00000100888","Wnt signaling pathway","Deactivation of the beta-catenin transactivating complex","lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Malignant pleural mesothelioma",920.3,929.1,915,1070.5,1104.5,947.3,0.8853729622393749,-0.17564277819291121,0.06755179247859652,1.1703631225378042,0.2814914773238666,0.550534749683853,1754]
["Q9HD26-1","Golgi-associated PDZ and coiled-coil motif-containing protein [OS=Homo sapiens]",18,8,12,8,462,50.5,5.92,36.97,"transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","GOPC","ENSG00000047932","","RHOQ GTPase cycle; RHO GTPases regulate CFTR trafficking","",1830,1761.4,1744.5,2322.7,2081.8,2007.2,0.8322129856356348,-0.2649752948897305,0.02211472637070044,1.6553184298611905,0.17122514305450162,0.7664324622752864,944]
["Q9HDC9","Adipocyte plasma membrane-associated protein [OS=Homo sapiens]",50,18,71,18,416,46.5,6.16,226.63,"other metabolic processes","other membranes;other cell component","other molecular function","APMAP","ENSG00000101474","","","Ciliary landscape",10078.3,10002.4,10163.8,9063.3,9090.1,9211.9,1.1052135368514135,0.144325137755987,1.2472322109910444E-4,3.904052681594852,0.016278607553809898,1.7883827467170796,56]
["Q9NNX1","tuftelin [OS=Homo sapiens]",5,2,2,2,390,44.2,6,2.63,"developmental processes;signal transduction","non-structural extracellular;other cell component","extracellular structural activity;bone, tooth or skin structural activity","TUFT1","ENSG00000143367","","","",271.7,313.4,236.8,214.6,225.7,605.2,0.7861310377809659,-0.3471582839301812,0.59788479461247,0.223382491403182,0.7150940866998107,0.14563681323903566,6111]
["Q9NP80-1","Calcium-independent phospholipase A2-gamma [OS=Homo sapiens]",8,6,10,5,782,88.4,9.23,22.81,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle","other molecular function","IPLA2(GAMMA); PNPLA8","ENSG00000135241","","Acyl chain remodelling of PC; Acyl chain remodelling of PE","Eicosanoid synthesis",897.5,830.1,866.7,783.9,762.1,313.4,1.3952350220501237,0.4805081590347426,0.18816509788580843,0.725460929268473,0.4370189705902046,0.3594997102977203,3147]
["Q9NPF5","DNA methyltransferase 1-associated protein 1 [OS=Homo sapiens]",14,6,7,6,467,53,9.5,18.39,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","DMAP1","ENSG00000178028","","HATs acetylate histones","",491.5,493.5,532.4,591.5,574.2,645.8,0.8376483577146011,-0.2555833629562553,0.01802919838399752,1.7440235824925634,0.1552124982198326,0.8090733108525432,849]
["Q9NPI1-1","Bromodomain-containing protein 7 [OS=Homo sapiens]",30,17,35,17,651,74.1,6.39,99.61,"cell-cell signaling;cell cycle OR cell proliferation;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","BRD7","ENSG00000166164","Hepatocellular carcinoma","Regulation of TP53 Activity through Acetylation","",2795.1,2725.6,2750.9,3309.3,3424.7,3028.7,0.8472656129964047,-0.23911377765440167,0.014083894674463686,1.8512772314341641,0.13526831297720773,0.868803926320764,761]
["Q9NPR2-1","Semaphorin-4B [OS=Homo sapiens]",1,1,1,1,832,92.1,6.95,2.25,"","","","","","","","",137.5,137.7,153.6,138.9,148.4,239.4,0.814125688247579,-0.2966765536961848,0.37181625013371583,0.4296716334205456,0.563000822918444,0.24949097035526463,4827]
["Q9NQ25-7","Isoform 7 of SLAM family member 7 [OS=Homo sapiens]",32,4,13,1,188,21.3,6.02,48.57,"","","","SLAMF7","","","","",41.7,38.4,42.2,18.6,19.7,31.5,1.7521489971346704,0.8091254623177344,0.015196787036517913,1.8182482225689076,0.14095598534252465,0.8509164781744899,788]
["Q9NQ88","Fructose-2,6-bisphosphatase TIGAR [OS=Homo sapiens]",23,5,11,5,270,30,7.69,35.58,"other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","other molecular function","TIGAR","ENSG00000078237","Fructose and mannose metabolism; Metabolic pathways; Central carbon metabolism in cancer","TP53 Regulates Metabolic Genes","Genotoxicity pathway; Metabolic reprogramming in colon cancer; p53 transcriptional gene network",1043.8,994.8,960.3,920.3,915.5,556.2,1.253720735785953,0.32621602599859906,0.17533003845040931,0.7561436719513864,0.4261680249531233,0.37041913816793104,3007]
["Q9NQL2-1","Ras-related GTP-binding protein D [OS=Homo sapiens]",13,5,8,1,400,45.6,4.92,24.01,"stress response;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RRAGD","ENSG00000025039; ENSGGOG00000024195; ENSNLEG00000013157; ENSPPAG00000029815; ENSPTRG00000018420","Autophagy; mTOR signaling pathway; Shigellosis","Amino acids regulate mTORC1; TP53 Regulates Metabolic Genes; Regulation of PTEN gene transcription; mTORC1-mediated signalling; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK","Target of rapamycin (TOR) signaling",50.4,45.5,51.5,43,32,65.6,1.0483641536273116,0.06813993002253453,0.832790050761865,0.07946447192815391,0.8878154143842577,0.05167731895932271,6856]
["Q9NQS7","Inner centromere protein [OS=Homo sapiens]",17,16,29,15,918,105.4,9.44,76.56,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity","INCENP","ENSG00000149503","","SUMOylation of DNA replication proteins; Separation of Sister Chromatids; RHO GTPases Activate Formins; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",2310.4,2327.4,2339.2,2085.4,2243.2,2064.1,1.0914011294132369,0.12618144176623225,0.027004358883053987,1.568566128949611,0.18708517447984985,0.7279606266993494,1055]
["Q9NQW7-3","Isoform 3 of Xaa-Pro aminopeptidase 1 [OS=Homo sapiens]",42,21,59,20,666,74.8,5.88,197.11,"","","","XPNPEP1","","","","",5426.3,5568.6,5583.8,5401.5,5392.6,5708.2,1.0046296576840805,0.00666377056851118,0.8359203040727251,0.07783512585202272,0.8895954429917804,0.05080745045692866,6868]
["Q9NR28-1","Diablo homolog, mitochondrial [OS=Homo sapiens]",32,8,22,7,239,27.1,5.9,68.42,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion","","DIABLO","ENSG00000184047","Apoptosis; Apoptosis","Regulation of the apoptosome activity; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Release of apoptotic factors from the mitochondria","TNF-alpha signaling pathway; Nanomaterial induced apoptosis; Apoptosis; Complement system in neuronal development and plasticity",2808.7,2760.8,2797.9,2696.4,2651.3,2392.3,1.0810594315245476,0.11244583778936401,0.09455196257575284,1.0243294522554944,0.3305022929058716,0.4808255231891933,2091]
["Q9NR34","mannosyl-oligosaccharide 1,2-alpha-mannosidase IC [OS=Homo sapiens]",1,1,1,1,630,70.9,7.46,2.08,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","MAN1C1","ENSG00000117643","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum","Intra-Golgi traffic; Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2","",110.2,115.4,109,139.2,127.3,129.3,0.8453764527539162,-0.24233416700915938,0.00809261178838537,2.091911292698502,0.10487393539239126,0.9793324347978712,564]
["Q9NRA0-1","Sphingosine kinase 2 [OS=Homo sapiens]",2,1,3,1,654,69.2,6.95,7.09,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","SPHK2","ENSG00000063176","Sphingolipid metabolism; Metabolic pathways; Calcium signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; VEGF signaling pathway; Apelin signaling pathway; Fc gamma R-mediated phagocytosis; Tuberculosis","Sphingolipid de novo biosynthesis","Sphingolipid pathway; S1P receptor signal transduction; Metabolism of spingolipids in ER and Golgi apparatus; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway",121.5,110.4,117,123.5,138.6,185.1,0.7801878354203934,-0.3581065906488159,0.1565540761049614,0.8053356204338626,0.4086620508039867,0.3886356898921089,2800]
["Q9NRB3","carbohydrate sulfotransferase 12 [OS=Homo sapiens]",18,5,8,5,414,48.4,9.32,35.01,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","CHST12","ENSG00000136213","Glycosaminoglycan biosynthesis","Chondroitin sulfate biosynthesis","Metapathway biotransformation Phase I and II",600.7,642.4,603.3,825,830.8,681.3,0.790038937144324,-0.3400043364827876,0.0321336840041859,1.493039481389905,0.20108313046797494,0.6966243622823127,1168]
["Q9NRG7-1","Epimerase family protein sdr39u1 [OS=Homo sapiens]",5,1,3,1,319,34.7,9.77,10.09,"","","","","","","","",137.1,112.5,141.7,120.2,107.4,127.8,1.1010129431626332,0.13883142887211547,0.331725088244881,0.47922168170848356,0.5424113355664062,0.265671242956447,4470]
["Q9NRP0-1","oligosaccharyltransferase complex subunit OSTC [OS=Homo sapiens]",13,2,19,2,149,16.8,9.13,58.98,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","DC2; OSTC","ENSANAG00000024765; ENSCANG00000031432; ENSCATG00000035272; ENSCCAG00000023668; ENSCJAG00000042857; ENSG00000198856; ENSGGOG00000026873; ENSMFAG00000034553; ENSMLEG00000037144; ENSMMUG00000011902; ENSNLEG00000012929; ENSOGAG00000033684; ENSPANG00000016693; ENSPPAG00000043858; ENSPTRG00000024222; ENSRBIG00000031965; ENSRROG00000031431","","","",1268.6,1385.4,1348.6,1141.9,1183.3,1490.4,1.049009330118461,0.06902750961753915,0.6171687969230142,0.20959603929507586,0.7285023799596755,0.13756902508593907,6192]
["Q9NRR8","CDC42 small effector protein 1 [OS=Homo sapiens]",10,1,1,1,79,8.9,9.99,2.02,"transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","CDC42SE1","ENSG00000197622","","","",49.9,50.8,58.2,64.4,81.8,244.7,0.4064978255308263,-1.2986804599407715,0.24970752672192806,0.6025683668815912,0.49128191461926574,0.30866922309421235,3715]
["Q9NRX2","39S ribosomal protein L17, mitochondrial [OS=Homo sapiens]",9,2,4,2,175,20,10.11,9.19,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL17","ENSG00000158042","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",733.2,781.4,694.5,738.5,868.6,1117.5,0.8107979152903179,-0.3025857155105064,0.2061821392943556,0.68574895855718,0.4535014312676633,0.3434213379519181,3323]
["Q9NS00-1","Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 [OS=Homo sapiens]",18,6,13,6,363,42.2,6.64,40.84,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","C1GALT1","ENSG00000106392","Mucin type O-glycan biosynthesis; Other types of O-glycan biosynthesis; Metabolic pathways","O-linked glycosylation of mucins; Defective C1GALT1C1 causes TNPS","Ectoderm differentiation",1093.8,1050.7,1071.4,1153.8,1181.2,3274.5,0.573295302611641,-0.8026496367590077,0.31948659111937117,0.4955473645010998,0.5373049918296098,0.26977912460163256,4346]
["Q9NS69","Mitochondrial import receptor subunit TOM22 homolog [OS=Homo sapiens]",63,5,47,5,142,15.5,4.34,200.86,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity","TOMM22","ENSG00000100216","","Mitochondrial protein import; PINK1-PRKN Mediated Mitophagy","",3220.2,3300,3290.1,2740,3276,3195.1,1.065051948192941,0.09092380000282106,0.3019937411042523,0.5200020578112386,0.5274246723371517,0.2778395582565445,4185]
["Q9NSD4","zinc finger protein 275 [OS=Homo sapiens]",3,1,1,1,429,48.4,9.09,2.04,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF275","ENSG00000063587","","","",89.8,84.4,98.2,275.1,276.2,226.4,0.3502635977883503,-1.5134870354346246,5.6981302599865111E-4,3.2442676269556614,0.02669720132707783,1.57353426342615,156]
["Q9NSG2-1","Uncharacterized protein C1orf112 [OS=Homo sapiens]",4,2,2,2,853,96.5,6,6.63,"","","","C1orf112","ENSG00000000460","","","",64.8,65.5,72.1,67.3,76.5,696.2,0.24095238095238095,-2.053180037859175,0.3649135659502962,0.43780999109454244,0.5593861689452003,0.2522882759427495,4768]
["Q9NSY1","BMP-2-inducible protein kinase [OS=Homo sapiens]",8,6,8,6,1161,129.1,6.51,19.35,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","BMP2K","ENSG00000138756","Transcriptional misregulation in cancer","","",729.8,726.7,738.1,777.9,781.7,678.7,0.9804762543001384,-0.02844540400922043,0.6894604949413091,0.16149061320171765,0.7838336844806391,0.10577607707923578,6429]
["Q9NTN3","UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter [OS=Homo sapiens]",2,1,3,1,355,39.2,8.97,6.69,"transport","other membranes;ER/Golgi","transporter activity","SLC35D1","ENSG00000116704","","Formation of the active cofactor, UDP-glucuronate; Transport of nucleotide sugars; Defective SLC35D1 causes SCHBCKD","",313.3,315,304.3,327.3,320.9,389.7,0.8985451392234317,-0.15433711424838045,0.18892557006527994,0.7237092586651326,0.4375339010162012,0.3589882913185424,3156]
["Q9NTX7","E3 ubiquitin-protein ligase rnf146 [OS=Homo sapiens]",9,3,3,3,359,38.9,5.33,4.98,"cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","RNF146","ENSG00000118518","","Degradation of AXIN; Ub-specific processing proteases; Regulation of PTEN stability and activity","",174,169.3,194.7,165.1,168,286.6,0.8681620138776827,-0.20396379552762364,0.540798998012402,0.266964121722648,0.6761375088047634,0.16996497086009263,5846]
["Q9NUL5","Repressor of yield of DENV protein [OS=Homo sapiens]",4,1,3,1,291,33.1,7.25,8.25,"stress response;other biological processes","cytosol;nucleus;other cell component","translation activity;nucleic acid binding activity;other molecular function","SHFL","ENSG00000130813","","","",318.9,307.1,338.7,306.5,323.5,516.2,0.8416506717850288,-0.2487065298337751,0.4231159357444784,0.3735406176004903,0.5916499663968611,0.2279351558142679,5227]
["Q9NUQ2","1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [OS=Homo sapiens]",35,12,28,12,364,42,9.1,77.29,"other metabolic processes;developmental processes","other membranes;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","AGPAT5","ENSG00000155189; ENSG00000284980","Glycerolipid metabolism; Glycerophospholipid metabolism; Metabolic pathways; Phospholipase D signaling pathway","Synthesis of PA","Triacylglyceride synthesis",2833.4,2749.2,2790.6,2689.9,2644.4,2252.9,1.1035955293125264,0.14221151742931126,0.1363174371304736,0.8654485875609145,0.38409566229245623,0.4155605974250028,2594]
["Q9NUQ3-1","Gamma-taxilin [OS=Homo sapiens]",22,10,16,9,528,60.5,7.52,45.14,"cell cycle OR cell proliferation;other biological processes","other membranes;cytosol;nucleus","other molecular function","TXLNG","ENSG00000086712","","","",1553,1564.7,1475.2,1844.5,1739.6,825.1,1.0416628866914632,0.05888845382664832,0.8597073645569677,0.06564935292586742,0.90541802990589,0.04315086149674938,6940]
["Q9NUU7","ATP-dependent RNA helicase DDX19A [OS=Homo sapiens]",49,21,55,4,478,53.9,6.58,145.47,"other metabolic processes;transport","nucleus;other cell component","nucleic acid binding activity;other molecular function","DDX19A","ENSG00000168872","Nucleocytoplasmic transport; mRNA surveillance pathway","","",7375.3,7310.7,7314.8,7095.5,7217,6640.4,1.0500121701530574,0.07040604952731269,0.11928207381950656,0.923424818913388,0.36265918367170275,0.440501320360117,2404]
["Q9NUY8","TBC1 domain family member 23 [OS=Homo sapiens]",16,8,13,8,699,78.3,5.41,44.18,"cell organization and biogenesis;transport;developmental processes","cytosol;ER/Golgi;other cell component","","TBC1D23","ENSG00000036054","","","",727.5,700.5,710.9,707,665.3,937,0.9262114060537825,-0.11058657132026983,0.5398584234189737,0.2677201179353103,0.6755393283289298,0.17034936229103145,5841]
["Q9NV96","Cell cycle control protein 50A [OS=Homo sapiens]",24,7,26,7,361,40.7,8.59,87.23,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity","TMEM30A","ENSG00000112697","","Neutrophil degranulation","",2372.5,2409.2,2448.3,2430.2,2639.5,2131.8,1.0039575088523225,0.005698210458729712,0.9521984713624392,0.02127252006733718,0.9687665126932166,0.013780881842612185,7184]
["Q9NVG8","TBC1 domain family member 13 [OS=Homo sapiens]",26,9,11,9,400,46.5,5.24,34.76,"transport;other biological processes","other membranes;cytosol","enzyme regulator activity;other molecular function","TBC1D13","ENSG00000107021","","TBC/RABGAPs","",1057.1,1084.8,1081.7,1000.8,1057,1085.8,1.0254485303473722,0.03625508140714827,0.3704342215834349,0.4312888989924734,0.5621893117843284,0.25011741535826865,4816]
["Q9NVH2","Integrator complex subunit 7 [OS=Homo sapiens]",13,8,13,8,962,106.8,8.02,34.41,"RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","","INTS7","ENSG00000143493","","RNA polymerase II transcribes snRNA genes","",681.2,693.6,708.1,856.6,824.4,764.6,0.8516928361138373,-0.23159488006516404,0.012547549612623124,1.90144107845556,0.12844543433986333,0.8912813283477615,714]
["Q9NVM6","DnaJ homolog subfamily C member 17 [OS=Homo sapiens]",2,1,1,1,304,34.7,8.53,2.12,"transport;other biological processes","nucleus;other cell component","nucleic acid binding activity","DNAJC17","ENSG00000104129","","","",82.5,97.5,83.9,119.1,137.2,193.4,{"$f":"AVERAGE(S6402:U6402)/AVERAGE(V6402:X6402)","v":0.5868356682232599},{"$f":"LOG(Y6402,2)","v":-0.7689715333427475},{"$f":"TTEST(S6402:U6402,V6402:X6402,2,2)","v":0.053675127887786694},{"$f":"-LOG10(AA6402)","v":1.2702269121289025},{"$f":"AA6402*7309/AE6402","v":0.25229035995616267},{"$f":"-LOG10(AC6402)","v":0.5980993436077857},1555]
["Q9NVS2","39S ribosomal protein S18a, mitochondrial [OS=Homo sapiens]",18,3,8,3,196,22.2,10.33,26.3,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPS18A","ENSG00000096080","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",755.8,753.7,794.5,728.7,660.4,655.2,1.1270361492931567,0.17253379019476106,0.03323732899265647,1.4783738841165395,0.20346033300446073,0.6915202490259168,1194]
["Q9NVS9","Pyridoxine-5'-phosphate oxidase [OS=Homo sapiens]",41,7,19,7,261,30,7.06,69.9,"other metabolic processes","cytosol","other molecular function","PNPO","ENSG00000108439","Vitamin B6 metabolism; Metabolic pathways; Biosynthesis of cofactors","Vitamins B6 activation to pyridoxal phosphate","Selenium micronutrient network; Vitamin B6-dependent and responsive disorders",2357.6,2406.7,2474.5,2697.9,3014.2,4712,0.6944292552834296,-0.5261003672039574,0.16524672194980242,0.7818671469904777,0.41791982378238957,0.3789070278630526,2890]
["Q9NVX7-1","Kelch repeat and BTB domain-containing protein 4 [OS=Homo sapiens]",5,2,2,2,518,58.1,5.67,7.11,"","","","KBTBD4","ENSG00000123444; ENSG00000284900","","","",48.5,49.6,53.5,55.2,50.6,73.6,0.8450390189520623,-0.24291013674816966,0.2668609864322023,0.5737149129703287,0.5034814016089227,0.29801656746944777,3874]
["Q9NW13-1","RNA-binding protein 28 [OS=Homo sapiens]",31,21,47,20,759,85.7,9.22,121.73,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity","RBM28","ENSG00000106344","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol","",6385.3,6343.5,6124.3,9041.4,8969.1,10863.1,0.6529528704422032,-0.6149492318034232,0.005904897535385392,2.2287876340712627,0.08754339976903008,1.0577765914645199,493]
["Q9NW82","WD repeat-containing protein 70 [OS=Homo sapiens]",26,16,25,16,654,73.2,6.33,58.75,"other biological processes","nucleus;other cell component","other molecular function","WDR70","ENSG00000082068","","","",2640.8,2680.3,2712.1,2913.7,2924.1,3248.1,0.8841391606775334,-0.1776546318107699,0.034794107260473,1.4584943020580083,0.20793959931872213,0.6820627972103209,1223]
["Q9NWS8","Required for meiotic nuclear division protein 1 homolog [OS=Homo sapiens]",10,4,4,4,449,51.6,8.69,9.4,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","","RMND1","ENSG00000155906","","","",293.3,291.7,306.1,272,238.5,379.1,1.0016861510791366,0.002430553235454488,0.9912067307914048,3.8357575443808785E-3,0.9939264638982545,2.6457458889958788E-3,7289]
["Q9NWV4","UPF0587 protein C1orf123 [OS=Homo sapiens]",71,7,29,7,160,18,5.01,88.76,"","","other molecular function","CZIB","ENSG00000162384","","","",4330.6,4308.6,4039.9,4276.2,4756,2372.8,1.1117141604559404,0.15278589570276271,0.59372899841501,0.22641173910818652,0.7121045699729748,0.14745622711086837,6094]
["Q9NWY4","Histone PARylation factor 1 [OS=Homo sapiens]",28,10,19,10,346,39.4,6.8,59.54,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","other molecular function","HPF1","ENSG00000056050","","","",2723.5,2662.7,2675.6,2934.3,2989.8,2963.4,0.9070942334739802,-0.1406756619904976,3.5612799370223944E-4,3.4483938869475574,0.023034862884687327,1.6376143685470042,113]
["Q9NX14-1","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [OS=Homo sapiens]",44,5,28,5,153,17.3,5.22,75.73,"cell organization and biogenesis","other membranes;mitochondrion","","NDUFB11","ENSG00000147123","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Nonalcoholic fatty liver disease",2750.9,2900.1,2896.5,2992.6,3305.4,3821.9,0.8446229705827133,-0.24362061131063023,0.10085759877717453,0.9962913757588484,0.3381505456249397,0.47088990747948034,2180]
["Q9NX20","39S ribosomal protein L16, mitochondrial [OS=Homo sapiens]",35,8,24,8,251,28.4,10.13,68.39,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL16","ENSG00000166902","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",4730.4,4898.8,4880.5,4468.8,4933,5423.2,0.9787318718381113,-0.031014413966661016,0.7270600142841288,0.13842973935183203,0.8124264859199966,0.09021592659982443,6541]
["Q9NX63","MICOS complex subunit MIC19 [OS=Homo sapiens]",52,16,78,16,227,26.1,8.28,211.32,"cell organization and biogenesis","other membranes;mitochondrion;nucleus","other molecular function","CHCHD3","ENSG00000106554","","Mitochondrial protein import; Cristae formation","",10971.6,11427.4,10192.7,11986.4,12012.6,9566.3,0.9709938537716033,-0.04246593123186674,0.7331548743899252,0.13480427366966416,0.8173625651183593,0.08758525668415269,6556]
["Q9NX78","Transmembrane protein 260 [OS=Homo sapiens]",4,2,4,2,707,79.5,8.4,13.94,"","other membranes","","TMEM260","ENSG00000070269","","","",190.8,205.3,218.6,156,172.6,204.9,1.152202436738519,0.20439421402061536,0.17520668980894907,0.7564493154530733,0.42643546314139485,0.37014668576808135,3003]
["Q9NXF7","DDB1- and CUL4-associated factor 16 [OS=Homo sapiens]",7,1,2,1,216,24.2,6.04,8.54,"protein metabolism;other metabolic processes","nucleus;other cell component","","DCAF16","ENSG00000163257","","Neddylation","",155.7,188.7,172.3,229.2,232.1,187.9,0.7959026494146644,-0.3293361161231108,0.06174328021487858,1.2094103016213518,0.26958281666102,0.56930779339462,1674]
["Q9NXR7-1","Isoform 1 of BRISC and BRCA1-A complex member 2 [OS=Homo sapiens]",11,4,10,4,415,46.9,6.14,26.99,"","","","BABAM2","","","","",1052,1001.3,973.3,1028.1,1062.9,648,1.1050018254837533,0.14404875297795813,0.5164287294876173,0.286989605462787,0.6587395434249556,0.18128626554620397,5730]
["Q9NXX6","Non-structural maintenance of chromosomes element 4 homolog A [OS=Homo sapiens]",12,4,6,4,385,44.3,5.38,9.92,"DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","","NSMCE4A","ENSG00000107672","","SUMOylation of DNA damage response and repair proteins","",212.1,193.1,203.3,222.1,226.9,149.5,1.0167084377610693,0.023906015770226406,0.9028120789427855,0.04440263902371038,0.9350507984969277,0.029164794573871326,7057]
["Q9NY35-1","Claudin domain-containing protein 1 [OS=Homo sapiens]",14,3,7,3,253,28.6,5.82,21.12,"","plasma membrane;other membranes","","CLDND1","ENSCANG00000033095; ENSG00000080822; ENSGGOG00000007565; ENSPPYG00000013614","","","",508.7,520.5,516.3,418.4,460.1,392.7,1.2157803650094399,0.2818826243970666,0.010141603495734116,1.9938933729816881,0.1161833541541076,0.9348560898188775,638]
["Q9NYG2-1","Palmitoyltransferase ZDHHC3 [OS=Homo sapiens]",3,1,2,1,299,34.1,8.18,3.48,"protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","ZDHHC3","ENSCCAG00000029642; ENSG00000163812","","","",110.3,109.2,112.8,101,92.3,252.3,0.7457360861759426,-0.42326293964800027,0.50754007437028,0.29452966101915473,0.6510372768642291,0.18639414403863977,5698]
["Q9NYH9","U3 small nucleolar RNA-associated protein 6 homolog [OS=Homo sapiens]",20,10,15,10,597,70.1,7.28,50.5,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","UTP6","ENSG00000108651","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",1147.1,1160.2,1137.6,2099.6,1986.2,1642.5,0.601382609151057,-0.7336449463873133,5.2164973229081955E-3,2.2826210111605665,0.08234855061152484,1.0843440402945466,463]
["Q9NYP7-1","elongation of very long chain fatty acids protein 5 [OS=Homo sapiens]",3,1,11,1,299,35.3,9.42,23.14,"other metabolic processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","ELOVL5","ENSG00000012660; ENSGGOG00000011386; ENSPPAG00000035952; ENSPTRG00000018289","Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism","Synthesis of very long-chain fatty acyl-CoAs; alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Linoleic acid metabolism affected by coronavirus infection",1977.4,2099,2075.1,1949,2099,783.4,1.273233431303556,0.34849694344261517,0.3513033628007469,0.4543176929668183,0.5544539578299846,0.25613451207673876,4631]
["Q9NYU2-1","UDP-glucose:glycoprotein glucosyltransferase 1 [OS=Homo sapiens]",46,53,322,53,1555,177.1,5.63,1048.08,"protein metabolism;other metabolic processes;stress response;other biological processes","ER/Golgi;other cell component","other molecular function","UGGT1","ENSG00000136731","Protein processing in endoplasmic reticulum","ER Quality Control Compartment (ERQC)","IL-18 signaling pathway",30089.2,30401.8,30645.5,28775.3,28188.4,27790.3,1.0753061802392807,0.1047475080184687,2.9217577849160415E-3,2.5343557901246987,0.06262500777111833,1.2032522072332232,341]
["Q9NZ09-1","Ubiquitin-associated protein 1 [OS=Homo sapiens]",25,9,16,9,502,55,5.11,48.67,"protein metabolism;other metabolic processes;transport","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","UBAP1","ENSG00000165006","","HCMV Late Events; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy","",1338.4,1277,1314.8,1845.5,1822.9,1944.1,0.7002583518930957,-0.5140408096430664,1.7005832621560705E-4,3.7694020997443745,0.017263282032081554,1.76287663429167,72]
["Q9NZB2-1","Constitutive coactivator of PPAR-gamma-like protein 1 [OS=Homo sapiens]",34,34,120,34,1118,121.8,8.88,407.71,"","plasma membrane;other membranes;cytosol;nucleus","","FAM120A","ENSG00000048828; ENSRROG00000028506","","","VEGFA-VEGFR2 signaling pathway",14055.6,13395.1,13350.4,14975.1,14645.7,20396.3,0.815743015888566,-0.2938133643766147,0.17727631603276586,0.7513492819023929,0.4279103678611247,0.3686471908464551,3028]
["Q9NZJ4-1","Sacsin [OS=Homo sapiens]",1,4,4,4,4579,520.8,7.05,13.72,"other biological processes","mitochondrion;nucleus;other cell component","other molecular function","SACS","ENSG00000151835","","","",199.7,213.4,209.1,190.3,224.6,452.3,0.7174815498154982,-0.47898636181948967,0.37729339827486774,0.4233207938392362,0.5656692201007196,0.2474374519898189,4875]
["Q9NZJ7","Mitochondrial carrier homolog 1 [OS=Homo sapiens]",6,2,9,2,389,41.5,9.32,23.47,"cell organization and biogenesis;developmental processes;other biological processes","other membranes;mitochondrion","","MTCH1","ENSG00000137409","","","IL-18 signaling pathway",752.8,713.6,687.6,698.1,695.6,1375.5,0.7778419760219558,-0.362451003385145,0.41742957281729076,0.37941678656809597,0.5867293745618419,0.2315621683189222,5200]
["Q9NZM4","BRD4-interacting chromatin-remodeling complex-associated protein [OS=Homo sapiens]",1,1,1,1,1560,158.4,6.65,2.78,"other biological processes","nucleus","other molecular function","BICRA","ENSG00000063169","","","",23.3,20.3,24.4,23.6,20.7,14.7,1.152542372881356,0.2048197918884982,0.3582998177206423,0.4457534127742728,0.5566022035537034,0.25445507865357553,4705]
["Q9NZN8-1","CCR4-NOT transcription complex subunit 2 [OS=Homo sapiens]",16,8,13,8,540,59.7,7.66,30.49,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","Cnot2; CNOT2; LOC111142051","ENSAMEG00000011938; ENSBIXG00000020780; ENSBIXG00005028198; ENSBMUG00000006457; ENSBTAG00000003748; ENSCAFG00000000441; ENSCANG00000037683; ENSCATG00000036994; ENSCCAG00000033920; ENSCSAG00000004177; ENSDLEG00000001866; ENSFCAG00000024278; ENSG00000111596; ENSGGOG00000027402; ENSLAFG00000004789; ENSLCNG00005003598; ENSMFAG00000034373; ENSMLEG00000041145; ENSMMUG00000014853; ENSMNEG00000045426; ENSMPUG00000017494; ENSPANG00000018112; ENSPCTG00005004059; ENSPPAG00000042482; ENSPTRG00000005216; ENSRBIG00000039989; ENSRFEG00010003667; ENSRROG00000042572; ENSSBOG00000026423; ENSSSUG00005015658; ENSUMAG00000020863","RNA degradation","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","",1464.7,1454.7,1484.4,1689.7,1572,1082.8,1.0136494418229947,0.01955880028318466,0.920491556516289,0.035980190837535,0.9475877164193741,0.02338057767263733,7100]
["Q9P015","39S ribosomal protein L15, mitochondrial [OS=Homo sapiens]",40,10,20,10,296,33.4,10.01,72.38,"protein metabolism;other metabolic processes;other biological processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL15","ENSG00000137547","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",2268.4,2477.1,2470.9,2195.5,2298.5,2305.9,1.0612509007485404,0.08576577828234293,0.14676814984783085,0.8333681804288361,0.39804393589528597,0.4000689880676206,2695]
["Q9P0J1","[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial [OS=Homo sapiens]",7,3,6,3,537,61,6.67,16.84,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","other molecular function","PDP1","ENSG00000164951","","Regulation of pyruvate dehydrogenase (PDH) complex","Orexin receptor pathway",404.1,380.3,398.4,384.7,304.2,905.6,0.7417999372844153,-0.4308979490192988,0.50718997563593,0.2948293386614628,0.6508166313067086,0.18654135740628985,5696]
["Q9P0L0","vesicle-associated membrane protein-associated protein A [OS=Homo sapiens]",67,14,116,2,249,27.9,8.62,298.47,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","VAPA","ENSG00000101558","Cholesterol metabolism","Neutrophil degranulation; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; Sphingolipid de novo biosynthesis","Exercise-induced circadian regulation",16892.9,18276.9,18096.1,17705.1,19234.7,23910.2,0.8753640098603123,-0.19204502535342635,0.25754012765775736,0.5891550933700274,0.4962722892303054,0.304279974188845,3793]
["Q9P0U4","CXXC-type zinc finger protein 1 [OS=Homo sapiens]",14,8,9,8,656,75.7,8.24,25.33,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","CXXC1","ENSG00000154832","","XBP1(S) activates chaperone genes","Male infertility",455.7,469.8,497,486.4,491.9,510.8,0.9552749983211337,-0.06601198833227623,0.19288764361403749,0.7146955923774689,0.4407051538527665,0.35585187057760304,3199]
["Q9P1Y6-1","PHD and RING finger domain-containing protein 1 [OS=Homo sapiens]",7,11,18,10,1649,178.6,8.95,39.76,"RNA metabolism OR transcription;other metabolic processes","","other molecular function","KIAA1542; PHRF1","ENSG00000070047; ENSG00000274780","","","",1495.3,1639.8,1641.6,1434.1,1541.9,1609.4,1.041719370174903,0.05896668089343082,0.41624122971739336,0.3806549040573174,0.5858477080694066,0.23221526476840068,5193]
["Q9P206","Uncharacterized protein KIAA1522 [OS=Homo sapiens]",2,1,2,1,1035,107,9.73,8.5,"other biological processes","","","KIAA1522","ENSG00000162522","","","",12,13,11.4,8.4,13,19.1,0.8987654320987654,-0.15398345757329093,0.6852711477589482,0.16413755306931363,0.7804061731022361,0.10767930394482597,6418]
["Q9P275","Ubiquitin carboxyl-terminal hydrolase 36 [OS=Homo sapiens]",3,4,6,4,1121,122.6,9.67,13.86,"","","","","","","","",263.4,271.4,278.5,529.1,609.7,529.3,0.487560697799892,-1.0363462596890076,4.6840773631822623E-4,3.3293759406437182,0.02410980383626701,1.617806323142802,142]
["Q9P287","BRCA2 and CDKN1A-interacting protein [OS=Homo sapiens]",37,10,30,10,314,36,4.61,75.8,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus","enzyme regulator activity;cytoskeletal activity","BCCIP","ENSG00000107949","","","",3404.5,3308.1,3391.7,3395.1,3431.7,2737.9,1.0564157788534925,0.07917775518227729,0.47327623784422806,0.32488529995244136,0.62825572510052,0.20186354512577984,5506]
["Q9P2E9-1","Ribosome-binding protein 1 [OS=Homo sapiens]",74,90,756,2,1410,152.4,8.6,2319.83,"","","","","","","","",90144.3,88986.9,89416.4,98845.2,102195.2,115150.4,0.8493213591287285,-0.2356175629001515,0.033313142056781944,1.4773844032269408,0.20324353530302106,0.6919832593962605,1198]
["Q9P2K5-1","Myelin expression factor 2 [OS=Homo sapiens]",8,6,16,6,600,64.1,8.75,44.33,"stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","MYEF2","ENSG00000104177","","","Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Mitochondrial gene expression",1896.9,1881.7,1903.2,2748.8,2154.6,2391.6,0.7788622344071282,-0.36055992874989384,0.03581565059385076,1.4459271554434283,0.2090867333789578,0.6796735224338661,1252]
["Q9P2M7-1","cingulin [OS=Homo sapiens]",18,23,34,23,1197,136.3,5.54,88.33,"","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity","CGN","ENSG00000143375","Tight junction","TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)","",2698.6,2609.6,2661,3284.1,3374.8,4248.9,0.7305964539137132,-0.4528533435601605,0.033750825293114066,1.4717156031036758,0.20404034910452498,0.6902839420804747,1209]
["Q9P2X0-1","Dolichol-phosphate mannosyltransferase subunit 3 [OS=Homo sapiens]",24,2,11,2,92,10.1,5.94,36.9,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi;other cell component","enzyme regulator activity","DPM3","ENSG00000179085","N-Glycan biosynthesis; Metabolic pathways","Synthesis of dolichyl-phosphate mannose; Defective DPM1 causes DPM1-CDG (CDG-1e); Defective DPM3 causes DPM3-CDG (CDG-1o); Defective DPM2 causes DPM2-CDG (CDG-1u)","",1111.9,1288.1,1425.7,984.5,1168.3,1177.9,1.1486174077521243,0.19989833161749182,0.20962797835981078,0.6785507539575115,0.4560032422118622,0.34103206946338266,3360]
["Q9UBC2-2","Isoform 2 of Epidermal growth factor receptor substrate 15-like 1 [OS=Homo sapiens]",37,29,73,2,910,99.5,5.08,234.54,"","","","EPS15L1","","","","",6320,6147.5,6133.6,6578.5,7071.1,6379.2,0.9287176465889119,-0.10668804702212342,0.09042553829750354,1.0437088972310973,0.32445766294376693,0.48884196434728844,2037]
["Q9UBD5-1","Origin recognition complex subunit 3 [OS=Homo sapiens]",22,13,21,12,711,82.2,7.61,48.09,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","ORC3","ENSG00000135336","Cell cycle","CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Assembly of the ORC complex at the origin of replication; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation","Cell cycle; G1 to S cell cycle control; DNA replication",1387,1386.4,1435.8,1364.7,1418.2,1248.2,1.0441814889236187,0.06237248816659404,0.3236615366252781,0.4899089083327392,0.5389934315776163,0.26841652729373944,4389]
["Q9UBM7","7-dehydrocholesterol reductase [OS=Homo sapiens]",23,11,81,11,475,54.5,8.7,186.98,"other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","DHCR7","ENSG00000172893","Steroid biosynthesis; Metabolic pathways","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis via desmosterol; Cholesterol biosynthesis via lathosterol","Vitamin D metabolism; Cholesterol biosynthesis pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias",10009,9744.4,9616.7,9074,9042.4,9645.7,1.057920690437683,0.08123147641128724,0.07804383774158517,1.1076613826781705,0.3042252853617312,0.5168046928579353,1875]
["Q9UBQ7","Glyoxylate reductase/hydroxypyruvate reductase [OS=Homo sapiens]",35,10,41,10,328,35.6,7.39,118.2,"other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle;other cell component","other molecular function","GRHPR","ENSG00000137106","Glycine, serine and threonine metabolism; Pyruvate metabolism; Glyoxylate and dicarboxylate metabolism; Metabolic pathways","Glyoxylate metabolism and glycine degradation","",4090,3982.4,4098.2,4041.3,3994,4479.8,0.9724732523112081,-0.040269525291009536,0.5103504093204032,0.2921315325722399,0.6533808270665313,0.18483361369494977,5709]
["Q9UBS0","Ribosomal protein S6 kinase beta-2 [OS=Homo sapiens]",20,4,6,4,482,53.4,7.34,21.13,"protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus;other cell component","kinase activity;other molecular function","RPS6KB2","ENSG00000175634","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; ErbB signaling pathway; HIF-1 signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; TGF-beta signaling pathway; Apelin signaling pathway; Fc gamma R-mediated phagocytosis; Thermogenesis; Insulin signaling pathway; Insulin resistance; Shigellosis; Human cytomegalovirus infection; Human papillomavirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Proteoglycans in cancer; Chemical carcinogenesis; Colorectal cancer; Pancreatic cancer; Acute myeloid leukemia; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer","Constitutive Signaling by AKT1 E17K in Cancer; AKT phosphorylates targets in the nucleus","IL-5 signaling pathway; AMP-activated protein kinase (AMPK) signaling; Follicle stimulating hormone (FSH) signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Thermogenesis; Translation inhibitors in chronically activated PDGFRA cells; Head and neck squamous cell carcinoma; Cytoplasmic ribosomal proteins; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; Malignant pleural mesothelioma; ErbB signaling pathway",280.4,282.5,281.3,267,302.6,319.1,0.9499268594576348,-0.07411165887529492,0.3895783690130749,0.40940516493268697,0.5732692367861012,0.24164136304393732,4967]
["Q9UBU6","Protein FAM8A1 [OS=Homo sapiens]",13,2,4,2,413,44.1,7.21,15.08,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","","FAM8A1","ENSG00000137414","","","",202.7,175.3,208.2,198.5,221.7,232.1,0.8986662578568145,-0.15414266049375921,0.19615136099852443,0.7074086741666225,0.44317474421583153,0.3534249972873687,3235]
["Q9UBV2","Protein sel-1 homolog 1 [OS=Homo sapiens]",22,13,47,13,794,88.7,5.39,129.68,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;ER/Golgi","","SEL1L","ENSG00000071537","Protein processing in endoplasmic reticulum","ABC-family proteins mediated transport; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Defective CFTR causes cystic fibrosis; ER Quality Control Compartment (ERQC); Pre-NOTCH Processing in Golgi","Genotoxicity pathway; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5",2497.5,2575.3,2579.3,2729.8,2845.4,1926.2,1.0200895832777883,0.028695853839438172,0.8710191608181582,0.05997229120810483,0.9115519825916264,0.04021856002164516,6984]
["Q9UDW1","cytochrome b-c1 complex subunit 9 [OS=Homo sapiens]",38,2,6,2,63,7.3,9.47,16.43,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","UQCR10","ENSG00000184076","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly",985,1011.9,1024.6,809.2,859.4,551,1.3612813119480986,0.444965233935902,0.04996336950227634,1.3013482807282406,0.2452533698402537,0.6103850165964437,1489]
["Q9UER7-1","Death domain-associated protein 6 [OS=Homo sapiens]",7,6,13,6,740,81.3,4.87,27.33,"cell organization and biogenesis;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","DAXX","ENSG00000204209; ENSG00000206206; ENSG00000206279; ENSG00000227046; ENSG00000231617","MAPK signaling pathway; Apoptosis; Parkinson disease; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Herpes simplex virus 1 infection","HCMV Early Events; Inhibition of DNA recombination at telomere; Regulation of TP53 Degradation; SUMOylation of transcription cofactors; Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations; Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations","Androgen receptor signaling pathway; Amyotrophic lateral sclerosis (ALS); Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; p38 MAPK signaling pathway",1724.2,1652.2,1731.8,2004.1,2021.9,1567.1,0.9133038922958645,-0.1308331131448563,0.3443510589955679,0.4629985770746991,0.5515805150555787,0.258391083963387,4563]
["Q9UEW8","STE20/SPS1-related proline-alanine-rich protein kinase [OS=Homo sapiens]",22,11,31,9,545,59.4,6.29,89.07,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","STK39","ENSG00000198648","","","",2524.8,2564.3,2507.1,2496.9,2392,1922,1.1153004742398218,0.15743244045643762,0.21444948790470664,0.6686749864984713,0.4605969165722894,0.33667897371030775,3403]
["Q9UFW8","CGG triplet repeat-binding protein 1 [OS=Homo sapiens]",25,3,3,3,167,18.8,8.95,11.39,"cell organization and biogenesis;other biological processes","nucleus","nucleic acid binding activity;other molecular function","CGGBP1","ENSG00000163320","","","",375.9,376.9,419.2,383.7,354.4,353.2,1.0739485017868597,0.10292481455422145,0.19719484255462022,0.7051044478094094,0.44443327296691926,0.3521934345984093,3243]
["Q9UG63","ATP-binding cassette sub-family F member 2 [OS=Homo sapiens]",38,26,112,26,623,71.2,7.37,269.11,"transport","","transporter activity;other molecular function","ABCF2","ENSG00000033050","Pathogenic Escherichia coli infection","","VEGFA-VEGFR2 signaling pathway",15295.7,15114.3,15212.1,17046.7,16816.5,13743.9,0.958304538608737,-0.06144389349595988,0.568390966264635,0.24535283315941192,0.6963408602796208,0.1571781203014828,5966]
["Q9UGP4","LIM domain-containing protein 1 [OS=Homo sapiens]",34,15,32,15,676,72.1,6.65,121.56,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","LIMD1","ENSG00000144791","Hippo signaling pathway; Hippo signaling pathway","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Malignant pleural mesothelioma",2906.3,2924.1,2956.9,3581.3,3726.7,2844.1,0.865564760000394,-0.20828633140609337,0.17170733624720652,0.7652111490812772,0.42284667137157433,0.3738170838042936,2968]
["Q9UGU5","HMG domain-containing protein 4 [OS=Homo sapiens]",7,3,3,3,601,65.7,9.32,9.13,"cell-cell signaling;transport;signal transduction;other biological processes","nucleus","nucleic acid binding activity;other molecular function","HMGXB4","ENSG00000100281","","","",151.9,147.1,137.5,167.2,147.2,135.5,0.9702156034674372,-0.04362271306224373,0.6834058245025596,0.16532132413464837,0.7788886903616417,0.10852460216791454,6413]
["Q9UH17-1","DNA dC->dU-editing enzyme APOBEC-3B [OS=Homo sapiens]",21,6,14,4,382,45.9,6.06,42.85,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","other molecular function","APOBEC3B","ENSG00000179750","Human immunodeficiency virus 1 infection","Formation of the Editosome","",435.1,445.8,458.4,781.6,688.1,558.5,{"$f":"AVERAGE(S6722:U6722)/AVERAGE(V6722:X6722)","v":0.6603392170397397},{"$f":"LOG(Y6722,2)","v":-0.5987207658401907},{"$f":"TTEST(S6722:U6722,V6722:X6722,2,2)","v":0.024208603591585005},{"$f":"-LOG10(AA6722)","v":1.6160302609489972},{"$f":"AA6722*7309/AE6722","v":0.1780087360672986},{"$f":"-LOG10(AC6722)","v":0.7495586834623373},994]
["Q9UHB7-1","AF4/FMR2 family member 4 [OS=Homo sapiens]",10,9,12,9,1163,127.4,9.31,24.62,"other biological processes","nucleus;other cell component","","AFF4","ENSG00000072364","","RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex","",670.8,642.7,665.4,510.8,527.4,689.4,1.1454619124797407,0.19592948868175752,0.21964932289904887,0.6582701311724373,0.4646648049404192,0.3328602209986815,3455]
["Q9UHG3","prenylcysteine oxidase 1 [OS=Homo sapiens]",29,12,37,12,505,56.6,6.18,118.54,"protein metabolism;other metabolic processes;transport","non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle","other molecular function","PCYOX1","ENSG00000116005","Terpenoid backbone biosynthesis","","",4151.6,4276.9,4274.3,3712.2,3092.6,3968.9,1.1790564058772752,0.23763273827770257,0.07108249887354033,1.148237313169583,0.29024691858475216,0.5372323822655033,1790]
["Q9UHJ6","Sedoheptulokinase [OS=Homo sapiens]",18,5,12,5,478,51.5,6.83,47.44,"other metabolic processes;other biological processes","cytosol;other cell component","kinase activity;other molecular function","SHPK","ENSG00000197417","Metabolic pathways","Pentose phosphate pathway","",878.5,806.2,829.2,811.1,678.7,3818.4,0.4735880336083794,-1.0782954667751319,0.4150806917608158,0.3818674681554784,0.5855674148001935,0.2324230985586267,5181]
["Q9UHQ4","B-cell receptor-associated protein 29 [OS=Homo sapiens]",37,12,28,12,241,28.3,9.54,66.24,"transport;other biological processes","other membranes;ER/Golgi","","BCAP29","ENSG00000075790; ENSG00000283852","","","",3949.7,4162.4,4168.8,4050.9,4329.4,3711.1,1.0156722960120417,0.02243499543663537,0.7595401070554214,0.11944928853856664,0.8350599642701677,0.07828233743064826,6648]
["Q9UHW5-1","GPN-loop GTPase 3 [OS=Homo sapiens]",12,2,2,2,284,32.7,4.5,4.46,"","other cell component","other molecular function","GPN3","ENSG00000111231; ENSNLEG00000029104; ENSPPAG00000031515","","","",68.2,75.1,65.6,77.3,75.2,122.8,0.7588085724664003,-0.39819211752845285,0.23350150571178763,0.631710314583041,0.47592373264011595,0.32246263792523217,3586]
["Q9UI09","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [OS=Homo sapiens]",6,1,3,1,145,17.1,9.63,7.87,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;mitochondrion","transporter activity","NDUFA12","ENSG00000184752","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease",461.1,460.1,434.8,572.7,488.5,5215.5,0.2160370895534278,-2.2106490773074468,0.3528905815266421,0.4523599325881522,0.5548025941876161,0.25586151688726627,4649]
["Q9UI32","Glutaminase liver isoform, mitochondrial [OS=Homo sapiens]",1,1,2,1,602,66.3,7.3,4.69,"other metabolic processes;other biological processes","mitochondrion","other molecular function","GLS2","ENSG00000135423","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; D-Amino acid metabolism; Metabolic pathways; Glutamatergic synapse; GABAergic synapse; Proximal tubule bicarbonate reclamation; MicroRNAs in cancer; Central carbon metabolism in cancer","TP53 Regulates Metabolic Genes; Glutamate and glutamine metabolism; Glutamate Neurotransmitter Release Cycle","p53 transcriptional gene network; Neuroinflammation and glutamatergic signaling",350.6,319.5,329.1,256.7,211.8,134,1.6584232365145226,0.7298122356032709,0.023300559954696445,1.6326336419648537,0.17593367015379785,0.7546510373892744,968]
["Q9UIA9","exportin-7 [OS=Homo sapiens]",31,26,75,26,1087,123.8,6.32,238.09,"transport","nucleus;other cell component","other molecular function","XPO7","ENSG00000130227","Nucleocytoplasmic transport","","",6184.6,6236.7,6327.3,5700,6001.3,7021.5,1.001377999017241,1.9866638522587927E-3,0.9839577626249157,0.007023543695314209,0.9895084324470981,0.004580500447337966,7268]
["Q9UII2-1","ATPase inhibitor, mitochondrial [OS=Homo sapiens]",24,4,10,4,106,12.2,9.35,31.07,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","mitochondrion;other cell component","enzyme regulator activity;other molecular function","ATP5IF1","ENSG00000130770; ENSG00000285390; ENSPPAG00000043083; ENSPPYG00000001644; ENSPTRG00000000428","","","Electron transport chain: OXPHOS system in mitochondria",829,740,760.2,680.2,661.7,675.3,1.1546698393813206,0.2074803934774963,0.019408118746442656,1.712016559286291,0.16046825782550836,0.7946108624153913,884]
["Q9UJ04","testis-specific Y-encoded-like protein 4 [OS=Homo sapiens]",2,1,2,1,414,45.1,8.57,4.23,"cell organization and biogenesis","nucleus;other cell component","other molecular function","TSPYL4","ENSG00000187189","","","",271.1,303.4,283,228.9,231,79.7,1.5891401037805781,0.6682463229992694,0.10612918650347615,0.974165164691485,0.3442957053501585,0.4630683945313429,2253]
["Q9UJ70","N-acetyl-D-glucosamine kinase [OS=Homo sapiens]",53,12,63,12,344,37.4,6.24,220.03,"other metabolic processes","cytosol","kinase activity;other molecular function","NAGK","ENSG00000124357","Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars","Synthesis of UDP-N-acetyl-glucosamine","",6013.2,5892.7,5873.2,6324.2,6202.2,5875.8,0.9661399180532761,-0.049695957105717524,0.2142744893378,0.6690295312414937,0.46062713016764123,0.33665048639977585,3400]
["Q9UJF2","ras GTPase-activating protein nGAP [OS=Homo sapiens]",6,6,7,5,1139,128.5,8.24,17.53,"signal transduction;other biological processes","cytosol","enzyme regulator activity","RASAL2","ENSG00000075391","Ras signaling pathway","Regulation of RAS by GAPs; RND1 GTPase cycle; RND3 GTPase cycle","Ras signaling",211.3,269.2,235.8,258.2,279.6,347.2,0.8093785310734463,-0.30511351314547247,0.15013542365493657,0.8235168261924165,0.40284134048969583,0.39486596754919107,2724]
["Q9UJQ1-1","Lysosome-associated membrane glycoprotein 5 [OS=Homo sapiens]",9,2,5,2,280,31.5,6.46,17.09,"other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","","LAMP5","ENSG00000125869","","","",378.8,374.5,363.2,462.5,462.6,243.1,0.955743879472693,-0.06530403873161507,0.8256662153630595,0.08319548551620715,0.8835716497933531,0.053758227313766754,6830]
["Q9UJX4","Anaphase-promoting complex subunit 5 [OS=Homo sapiens]",17,8,16,8,755,85,6.87,43.29,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","ANAPC5","ENSG00000089053","Cell cycle; Oocyte meiosis; Ubiquitin mediated proteolysis; IL-17 signaling pathway; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection","Separation of Sister Chromatids; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Inactivation of APC/C via direct inhibition of the APC/C complex; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Cell cycle",690.3,707,647.3,610.4,655.3,485.9,1.1672756337063255,0.22314527092315534,0.14308007991622387,0.8444208259513225,0.39314748274724826,0.40544450069841653,2660]
["Q9UK23","N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [OS=Homo sapiens]",6,3,4,3,515,56,6.6,12.23,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport","other membranes;ER/Golgi","other molecular function","NAGPA","ENSG00000103174","Lysosome","","",322.5,307.2,301.1,318.8,369.4,440.7,0.8245194437062628,-0.27837457938368865,0.13992122133164708,0.8541164126826105,0.3894456232722805,0.4095531725520981,2626]
["Q9UK45","U6 snRNA-associated Sm-like protein LSm7 [OS=Homo sapiens]",54,5,11,5,103,11.6,5.27,20.11,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","LSM7","ENSG00000130332","RNA degradation; Spliceosome","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease","mRNA processing",1180.8,1204,1145.5,1203.1,1268.4,913.7,1.0428630509275671,0.06054971517317521,0.6836966211102493,0.16513656641676727,0.7790986285773016,0.10840756012521593,6414]
["Q9UK97","F-box only protein 9 [OS=Homo sapiens]",9,3,3,3,447,52.3,6.15,9.57,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;other cell component","other molecular function","FBXO9","ENSG00000112146","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",264.9,232.1,244.5,282.5,265.3,548.2,0.6765510948905109,-0.5637292005058964,0.26862767138699317,0.5708492526066465,0.5055096936579643,0.2962705119586408,3884]
["Q9UKG9-1","peroxisomal carnitine O-octanoyltransferase [OS=Homo sapiens]",8,3,3,3,612,70.1,7.08,9.46,"other metabolic processes;transport","cytosol;other cytoplasmic organelle;other cell component","other molecular function","CROT","ENSG00000005469","Peroxisome","Peroxisomal protein import; Beta-oxidation of pristanoyl-CoA","",106.9,108.4,112.2,123.8,123.7,96.6,0.951758209822726,-0.07133298542480618,0.5794301449120174,0.23699891433006437,0.7031470910114453,0.15295381561667185,6023]
["Q9UKK3","Poly [ADP-ribose] polymerase 4 [OS=Homo sapiens]",19,24,55,24,1724,192.5,5.66,167.84,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","PARP4","ENSG00000102699","Base excision repair; Apoptosis","Maturation of nucleoprotein; Nicotinamide salvaging; Maturation of nucleoprotein","NAD+ biosynthetic pathways; 16p11.2 proximal deletion syndrome",3942.9,3889.5,3980.5,4340.3,4259.5,5710.1,0.8255054193250827,-0.27665040863101165,0.15219771298955298,0.8175918734752989,0.40392631962260084,0.3936978475122309,2754]
["Q9UKM9-1","RNA-binding protein Raly [OS=Homo sapiens]",74,19,91,1,306,32.4,9.17,296.76,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","RALY","ENSG00000125970","","","",13432.4,13470,13377.3,17710.5,16283.3,9766.3,0.9204663609086814,-0.1195630966549437,0.659931517031199,0.18050113009236696,0.7622375881765223,0.11790963869801417,6328]
["Q9UKQ2-1","Disintegrin and metalloproteinase domain-containing protein 28 [OS=Homo sapiens]",9,8,14,8,775,87.1,6.95,29.09,"protein metabolism;other biological processes","non-structural extracellular;plasma membrane;other membranes;mitochondrion","other molecular function","ADAM28","ENSG00000042980","","","",1354.1,1317.5,1416,1444.9,1472.7,1416.4,0.9431472081218274,-0.08444512796108573,0.06768503528891168,1.169507340322964,0.2814049618467892,0.5506682491767442,1758]
["Q9UKV5","E3 ubiquitin-protein ligase AMFR [OS=Homo sapiens]",20,6,8,6,643,72.9,6.39,27.33,"cell-cell signaling;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","AMFR","ENSG00000159461","Protein processing in endoplasmic reticulum","ER Quality Control Compartment (ERQC); N-glycan trimming in the ER and Calnexin/Calreticulin cycle","Sterol regulatory element-binding proteins (SREBP) signaling",401.2,438.2,404.5,377.8,432.2,465,0.975607843137255,-0.035626738547300196,0.7303606340787574,0.13646264300812824,0.8149932632796394,0.08884598111593833,6550]
["Q9UL15-1","BAG family molecular chaperone regulator 5 [OS=Homo sapiens]",25,8,17,8,447,51.2,6.05,44.99,"cell organization and biogenesis;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","BAG5","ENSG00000166170","","Regulation of HSF1-mediated heat shock response","",984.7,995.6,996.6,932.6,886.5,876.3,1.1044371892854494,0.1433113731675288,0.006122642594331944,2.213061091509844,0.08879046571819876,1.0516336660713963,504]
["Q9UL26","Ras-related protein Rab-22A [OS=Homo sapiens]",26,4,7,4,194,21.8,8.15,16.74,"cell organization and biogenesis;transport","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","RAB22A","ENSG00000124209","Endocytosis","RAB geranylgeranylation","",1020.8,1021.1,1042.5,716.9,816.9,261.7,1.717850181008076,0.7806042200959002,0.06589067869921551,1.18117601903,0.2775763519380785,0.5566175362729197,1735]
["Q9ULC3","Ras-related protein Rab-23 [OS=Homo sapiens]",27,6,13,6,237,26.6,6.6,31.71,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","RAB23","ENSG00000112210","","RAB geranylgeranylation","Genes related to primary cilium development (based on CRISPR); Ciliopathies",1438.9,1483.8,1473.2,1206.6,1309.9,1080.4,1.2221357279879896,0.2894045169253953,0.017070257201869995,1.7677599352114906,0.1506841906865553,0.8219323101123978,828]
["Q9ULH1-1","Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 [OS=Homo sapiens]",14,14,26,14,1129,125.4,7.31,81.99,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","ASAP1","ENSG00000153317","Endocytosis; Fc gamma R-mediated phagocytosis","VxPx cargo-targeting to cilium","EGF/EGFR signaling pathway; CCL18 signaling pathway",1972.4,1967.6,1959.6,1860.9,1884.6,1952.6,1.0353626647478984,0.0501362005625845,0.0726224093262659,1.138929346999205,0.2934202265150235,0.5325099519750457,1809]
["Q9ULJ3","Zinc finger and BTB domain-containing protein 21 [OS=Homo sapiens]",2,3,4,3,1066,118.8,8.29,9.48,"other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","ZBTB21","ENSG00000173276","","","",245.6,237,256.4,592.5,636.5,524.7,0.4213947653532531,-1.2467557020558466,5.1067468058140929E-4,3.2918556740739082,0.024883474935796804,1.6040889712456163,150]
["Q9ULN7-5","Isoform 2 of Paraneoplastic antigen-like protein 8B [OS=Homo sapiens]",2,1,1,1,635,68.6,5.45,0,"","","","PNMA8B","ENSG00000204851","","","",32,37.2,38.7,38.5,34.3,36.4,0.9880952380952381,-0.017277991431835473,0.863506601720762,0.06373433779549385,0.9078495040243166,0.04198613935213096,6952]
["Q9ULQ1-1","Two pore calcium channel protein 1 [OS=Homo sapiens]",3,2,2,2,816,94.1,8.27,6.27,"transport;signal transduction;other biological processes","other membranes;other cytoplasmic organelle","transporter activity;other molecular function","TPCN1","ENSG00000186815; ENSGGOG00000010443","Calcium signaling pathway","Stimuli-sensing channels","",114.2,118.4,109,95.7,92.7,85.3,1.2480818414322252,0.3197125402555342,0.005332528962424108,2.2730667770999466,0.08345921667314304,1.078525695782086,467]
["Q9ULU8-3","Isoform 3 of Calcium-dependent secretion activator 1 [OS=Homo sapiens]",4,3,5,1,1314,148.7,5.81,6.79,"","","","CADPS","","","","",36.4,46.8,45.5,40.1,37.4,55.4,0.9683972911963882,-0.04632905105547284,0.839749532889269,0.07585022906256406,0.8921118220766957,0.04958070541410245,6880]
["Q9ULZ3","apoptosis-associated speck-like protein containing a CARD [OS=Homo sapiens]",47,9,36,9,195,21.6,6.34,109.68,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function","PYCARD","ENSG00000103490","Necroptosis; NOD-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Legionellosis; Yersinia infection; Influenza A; Lipid and atherosclerosis","Neutrophil degranulation; The AIM2 inflammasome; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; CLEC7A/inflammasome pathway","Nucleotide-binding oligomerization domain (NOD) pathway; Nanomaterial-induced inflammasome activation; TYROBP causal network in microglia; Acute viral myocarditis; Cytosolic DNA-sensing pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Prostaglandin signaling",3588.6,3591.7,3479.7,3538.5,3974.9,3412.1,0.9756990526749348,-0.035491867350902845,0.6385665235919846,0.19479385278742403,0.7455723196379898,0.12751022411388074,6260]
["Q9UM13","Anaphase-promoting complex subunit 10 [OS=Homo sapiens]",11,2,3,2,185,21.2,9.06,7.44,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","","ANAPC10","ENSG00000164162","Cell cycle; Oocyte meiosis; Ubiquitin mediated proteolysis; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection","Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; Senescence-Associated Secretory Phenotype (SASP); APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Cell cycle",252.8,275.6,256.6,285.7,268.4,187.7,1.058236721488272,0.08166238616334229,0.6665506890149892,0.1761668183094819,0.7669740217271026,0.11521934584454878,6352]
["Q9UMS4","Pre-mRNA-processing factor 19 [OS=Homo sapiens]",51,15,72,15,504,55.1,6.61,239.65,"cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","PRPF19","ENSG00000110107","Spliceosome; Ubiquitin mediated proteolysis","mRNA Splicing - Major Pathway; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of TC-NER Pre-Incision Complex","",8598.3,8570.4,8730.4,9516.5,9443,6134,1.0321039312969493,0.04558825527378797,0.8217629170174927,0.08525346066242527,0.8805549275004918,0.05524354830960039,6821]
["Q9UNA1-1","Rho GTPase-activating protein 26 [OS=Homo sapiens]",6,4,5,4,814,92.2,6.64,11.44,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","ARHGAP26","ENSG00000145819","","RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOB GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOD GTPase cycle; RHOQ GTPase cycle","",514.5,495.8,552.2,482.9,418.3,989.1,0.8265883722160504,-0.274759025711845,0.5790725383317965,0.2372670303589027,0.7032969728592723,0.1528612518789915,6018]
["Q9UNF1","Melanoma-associated antigen D2 [OS=Homo sapiens]",41,19,58,18,606,64.9,9.32,192.7,"transport;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","","MAGED2","ENSG00000102316","","Platelet degranulation","",6519.3,6553.3,6486.3,8736.3,8331.5,8860,0.7543601848209258,-0.40667456240199046,1.8998107252662618E-4,3.7212896648719385,0.018033398170092346,1.7439224281604473,77]
["Q9UNM6","26S proteasome non-ATPase regulatory subunit 13 [OS=Homo sapiens]",61,21,115,21,376,42.9,5.81,329.62,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","PSMD13","ENSG00000185627","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection","Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease",17935,17790.3,17833.1,16496.8,15674.4,9014.6,1.300409364392582,0.3789658501858892,0.15671490071773173,0.804889708114521,0.40864402759397117,0.38865484399083416,2803]
["Q9UNS1","Protein timeless homolog [OS=Homo sapiens]",7,6,12,6,1208,138.6,5.4,27.19,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity","TIMELESS","ENSG00000111602","","Processing of DNA double-strand break ends","",352.2,319.1,353.2,524.2,513.7,737.1,0.5771830985915494,-0.79289904026816,0.027345514621254282,1.5631138991290583,0.18731805657614578,0.7274203566695552,1067]
["Q9UNZ2","NSFL1 cofactor p47 [OS=Homo sapiens]",61,22,122,1,370,40.5,5.1,384.24,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","NSFL1C","ENSG00000088833","Protein processing in endoplasmic reticulum","RHOH GTPase cycle","",14247.9,14428.8,14354.3,14706.7,15005.6,17377.1,0.9138149987045916,-0.13002597278403755,0.18520527945676468,0.7323466374906923,0.433311583722629,0.36319970081198205,3124]
["Q9UPN9-2","Isoform Beta of E3 ubiquitin-protein ligase TRIM33 [OS=Homo sapiens]",7,7,8,1,1110,120.5,6.67,20.82,"","","","TRIM33","","","","",64.3,61,70.4,81.2,86.9,63.8,0.8438982319965501,-0.24485906401919993,0.18169305966996985,0.7406616616000631,0.4303287664056415,0.3661996214432196,3086]
["Q9UPQ3-1","Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 [OS=Homo sapiens]",4,3,8,2,857,94.4,7.94,10.84,"transport","nucleus;other cell component","enzyme regulator activity;other molecular function","AGAP1","ENSG00000157985","Endocytosis","","",185,207.3,189.4,184.4,181.9,233.8,0.9693384435927346,-0.04492762569357103,0.7533547834946389,0.12300044979252578,0.8313860958119155,0.08019724295544095,6623]
["Q9UPT6","C-Jun-amino-terminal kinase-interacting protein 3 [OS=Homo sapiens]",4,7,12,4,1336,147.4,5.4,32.57,"cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","MAPK8IP3","ENSG00000138834","MAPK signaling pathway","","MAPK signaling pathway",926.3,871.9,910,244,246.7,379.3,3.1128735632183906,1.6382469794983014,2.0787611735139145E-4,3.6821954033972495,0.01787490049083906,1.747756367227569,85]
["Q9UPY8","Microtubule-associated protein RP/EB family member 3 [OS=Homo sapiens]",19,5,11,1,281,32,5.54,26.85,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MAPRE3","ENSG00000084764","","","",19.1,31.7,18.7,22.4,24.6,13,1.1583333333333334,0.21205047711498903,0.5992055103063321,0.2224242015091405,0.7158537225938184,0.14517571227382742,6118]
["Q9UPY8-2","Isoform 2 of Microtubule-associated protein RP/EB family member 3 [OS=Homo sapiens]",19,5,11,1,266,30.4,5.3,28.17,"","","","MAPRE3","","","","",213.1,200,183.1,194.9,218.3,448.5,0.6918881281188349,-0.5313893085508925,0.33796328395192243,0.4711304785483899,0.5466195269760127,0.26231485799561866,4519]
["Q9UQ90","Paraplegin [OS=Homo sapiens]",11,7,10,7,795,88.2,8.69,29.27,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes","other membranes;mitochondrion;other cell component","other molecular function","SPG7","ENSG00000197912","","Processing of SMDT1","",718.3,758.3,776.2,704.2,703.1,870,0.989241645808633,-0.015605118264162767,0.8948883785003473,0.04823113186233899,0.9296104545848548,0.031699000763789675,7036]
["Q9UQL6-1","histone deacetylase 5 [OS=Homo sapiens]",5,4,6,4,1122,121.9,6.24,18.79,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","HDAC5","ENSG00000108840","Apelin signaling pathway; Neutrophil extracellular trap formation; Alcoholism; Viral carcinogenesis; MicroRNAs in cancer","Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Regulation of PTEN gene transcription","MicroRNAs in cardiomyocyte hypertrophy; Cell differentiation - expanded index; Cell differentiation - index; Neural crest differentiation; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; VEGFA-VEGFR2 signaling pathway; Ethanol effects on histone modifications; Rett syndrome causing genes",273,273.1,271.2,279.3,268.1,372,0.8889493147705024,-0.1698269316409105,0.3597766876765868,0.4439669809054914,0.5570022898174483,0.25414301945277334,4721]
["Q9Y222-1","Cyclin-D-binding Myb-like transcription factor 1 [OS=Homo sapiens]",3,2,2,2,760,84.4,4.61,4.62,"cell cycle OR cell proliferation;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","DMTF1","ENSG00000135164","","","",69.2,93.2,80,97.5,83.5,79.9,0.9290916059793025,-0.106107245344501,0.5208961015913096,0.28324889283360705,0.6613218006828004,0.17958716040476805,5757]
["Q9Y248","Dna replication complex gins protein psf2 [OS=Homo sapiens]",16,3,4,3,185,21.4,5.44,9.5,"DNA metabolism;other metabolic processes;stress response","nucleus","","GINS2","ENSG00000131153","","Unwinding of DNA","",362.2,345.4,316.9,346.6,381.8,455,0.865725874598614,-0.20801781585140516,0.2001038471929068,0.6987445615457546,0.4469923652606833,0.349699894661067,3272]
["Q9Y259-1","Choline/ethanolamine kinase [OS=Homo sapiens]",8,3,3,3,395,45.2,5.49,5.95,"other metabolic processes","cytosol","kinase activity;other molecular function","CHKB","ENSG00000100288","Glycerophospholipid metabolism; Metabolic pathways; Choline metabolism in cancer","Synthesis of PC; Synthesis of PE","Fatty acid beta-oxidation; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids",188.7,174.2,202.7,180.1,175.5,597.2,0.5936188077246011,-0.7523912930547154,0.40889788616672024,0.38838513456305696,0.5824663126081774,0.23472918733446876,5131]
["Q9Y281-1","Cofilin-2 [OS=Homo sapiens]",33,5,42,1,166,18.7,7.88,107.36,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity","CFL2; CFL2b; LOC101358143; LOC111160529","ENSAMEG00000015508; ENSANAG00000001737; ENSBIXG00000015466; ENSBIXG00005004635; ENSBTAG00000015053; ENSCAFG00000032562; ENSCANG00000033619; ENSCCAG00000037328; ENSCHIG00000015758; ENSCJAG00000041665; ENSCPOG00000033162; ENSECAG00000000511; ENSFCAG00000008480; ENSG00000165410; ENSGGOG00000038032; ENSHGLG00000001467; ENSLCNG00005006126; ENSMFAG00000001352; ENSMLEG00000005793; ENSMMNG00015019505; ENSMMUG00000039560; ENSMNEG00000039241; ENSMPUG00000016306; ENSNLEG00000003417; ENSPANG00000021779; ENSPCOG00000013026; ENSPCTG00005008413; ENSPPAG00000007558; ENSPPYG00000005737; ENSPTRG00000006254; ENSRROG00000036826; ENSSBOG00000014011; ENSSSCG00000001959; ENSSSCG00015060726; ENSSSCG00025071059; ENSSSCG00030060165; ENSSSCG00035044355; ENSSSCG00040010975; ENSSSCG00045008975; ENSSSCG00050005802; ENSSSCG00055017925; ENSSSCG00060075576; ENSSSCG00065063654; ENSSSCG00070007061; ENSSSUG00005010833; ENSVVUG00000019333","Axon guidance; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Pertussis; Human immunodeficiency virus 1 infection","","Actin cytoskeleton regulation; G13 signaling pathway; G13 signaling pathway; Leptin signaling pathway; Microtubule cytoskeleton regulation; Microtubule cytoskeleton regulation; Leptin signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; G13 signaling pathway",55.7,67.5,55.3,63.6,55.9,53,1.0347826086956522,0.04932771236356833,0.7149745146377058,0.14570943840797423,0.8024798414445626,0.09556586840514607,6512]
["Q9Y2C4","Nuclease EXOG, mitochondrial [OS=Homo sapiens]",7,3,6,3,368,41.1,8.27,11.83,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes","other membranes;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","EXOG","ENSG00000157036","","","",770,712.3,735.5,743.2,738,671.8,1.0300975383186253,0.0427809504047864,0.4899418912231333,0.3098554257217741,0.6385494441779389,0.19480546879640337,5608]
["Q9Y2D4","Exocyst complex component 6B [OS=Homo sapiens]",9,7,9,6,811,94.1,6.46,28.88,"cell organization and biogenesis;transport","other membranes;other cell component","","EXOC6B","ENSG00000144036","","","Ciliary landscape",619.7,608.3,615.7,602.3,531.1,718.3,0.99567964573095,-0.006246456869271822,0.963425286965275,0.016181958970972427,0.976518571963555,0.010319492647923447,7211]
["Q9Y2H0-1","Isoform 2 of Disks large-associated protein 4 [OS=Homo sapiens]",3,2,2,2,989,107.5,7.3,6.2,"","","","DLGAP4","","","","",124.2,132.1,145.1,168.6,167.9,195.8,0.754086041705805,-0.40719894956286895,0.01669815450355682,1.7773315248530566,0.14938410191737675,0.8256956195014991,817]
["Q9Y2H6","Fibronectin type-III domain-containing protein 3a [OS=Homo sapiens]",11,9,18,9,1198,131.8,6.71,49.03,"cell adhesion;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","","FNDC3A","ENSG00000102531","","","",1300.8,1388.5,1390.6,1463.7,1450.1,825.3,{"$f":"AVERAGE(S7042:U7042)/AVERAGE(V7042:X7042)","v":1.0911449279238319},{"$f":"LOG(Y7042,2)","v":0.1258427358601753},{"$f":"TTEST(S7042:U7042,V7042:X7042,2,2)","v":0.6214869856609998},{"$f":"-LOG10(AA7042)","v":0.20656796133414954},{"$f":"AA7042*7309/AE7042","v":0.7317088238073852},{"$f":"-LOG10(AC7042)","v":0.1356617077003086},6208]
["Q9Y2K7","Lysine-specific demethylase 2A [OS=Homo sapiens]",18,21,32,21,1162,132.7,7.58,78.47,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus","nucleic acid binding activity;other molecular function","KDM2A","ENSG00000173120","","HDMs demethylate histones","",3144.4,3069.7,3083.7,3333.4,3320.5,2496.9,1.0160641692529615,0.02299151799554803,0.8684940271429538,0.061233163961587324,0.9103431585239995,0.0407948672825327,6973]
["Q9Y2R0","Cytochrome c oxidase assembly factor 3 homolog, mitochondrial [OS=Homo sapiens]",27,3,7,3,106,11.7,9.6,19.06,"cell organization and biogenesis;other biological processes","other membranes;mitochondrion","","COA3","ENSG00000183978","Thermogenesis","","Mitochondrial complex IV assembly",621.5,680.1,567.9,604.4,982.6,283.6,0.999411953383941,-8.4862147575503989E-4,0.9986558647149781,5.8414320897256166E-4,0.9993395009860043,2.8694585124210576E-4,7304]
["Q9Y2R9","28S ribosomal protein S7, mitochondrial [OS=Homo sapiens]",15,3,10,3,242,28.1,9.99,35.8,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPS7","ENSG00000125445","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1483.9,1786.5,1423.9,1572,1982.6,1426.1,0.9424980424438332,-0.08543847296177078,0.6593735017635517,0.1808685098302684,0.7617134383419945,0.1182083824054443,6327]
["Q9Y2S0-1","DNA-directed RNA polymerases I and III subunit RPAC2 [OS=Homo sapiens]",24,3,7,3,133,15.2,5.8,19.33,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","POLR1D","ENSG00000186184; ENSGGOG00000004235; ENSNLEG00000000358; ENSPTRG00000005734","RNA polymerase; Cytosolic DNA-sensing pathway","","Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway",570.9,553.1,533.2,604.5,638.3,889.7,0.7771160609613129,-0.363798016113808,0.1553215489879433,0.8087682869802144,0.4074821254676516,0.3898914371841862,2786]
["Q9Y2S7","Polymerase delta-interacting protein 2 [OS=Homo sapiens]",41,12,33,12,368,42,8.63,108.07,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component","nucleic acid binding activity","POLDIP2","ENSG00000004142","","","",3203.7,3038.8,3183,3231,2999.9,5148.5,0.8282949891909943,-0.27178343386447795,0.39424912002185364,0.40422926735880504,0.574704191910596,0.2405556350970298,5014]
["Q9Y2T2","ap-3 complex subunit mu-1 [OS=Homo sapiens]",30,8,16,7,418,46.9,6.93,58.53,"transport","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","AP3M1","ENSG00000185009","Lysosome","Association of TriC/CCT with target proteins during biosynthesis","",1393.9,1427.6,1523.9,1369.3,1354.9,1120.2,1.1303194256581002,0.17673053254440438,0.13594231390664677,0.8666453421205703,0.38348219696784297,0.4162547932224222,2591]
["Q9Y2U5","Mitogen-activated protein kinase kinase kinase 2 [OS=Homo sapiens]",8,4,5,2,619,69.7,8,15.49,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus","kinase activity;other molecular function","MAP3K2","ENSG00000169967","MAPK signaling pathway; Gap junction; GnRH signaling pathway","","IL-1 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; MAPK cascade; EGF/EGFR signaling pathway; Insulin signaling; Malignant pleural mesothelioma",208.4,205.4,181.3,230.2,191.5,185.3,0.9803953871499176,-0.028564398678931974,0.8214054678910745,0.08544241048283208,0.8803009625829711,0.055368823255338075,6820]
["Q9Y2U8","inner nuclear membrane protein Man1 [OS=Homo sapiens]",29,20,56,20,911,99.9,7.55,184,"cell organization and biogenesis;other biological processes","other membranes;nucleus","nucleic acid binding activity","LEMD3","ENSG00000174106","","RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOG GTPase cycle; RND2 GTPase cycle; RHOD GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; Initiation of Nuclear Envelope (NE) Reformation; Depolymerisation of the Nuclear Lamina","Envelope proteins and their potential roles in EDMD physiopathology",4881.3,5068.8,5022.9,5421.7,5449.2,6775,0.8485257198556038,-0.23696970459996175,0.11889423673209017,0.9248391968204506,0.362838403455051,0.44028675268705963,2395]
["Q9Y2V2","Calcium-regulated heat-stable protein 1 [OS=Homo sapiens]",29,4,22,4,147,15.9,8.21,91.27,"signal transduction;other biological processes","cytosol;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","CARHSP1","ENSG00000153048","","","",2907.5,2963.3,2953.5,2641.4,2660.6,2835.7,1.0843727343106773,0.11686074332578972,0.023440905828526256,1.6300256098583248,0.1759030602676575,0.7547266048529673,974]
["Q9Y2V7-1","Conserved oligomeric Golgi complex subunit 6 [OS=Homo sapiens]",7,5,6,5,657,73.2,5.76,14.61,"other metabolic processes;transport","other membranes;ER/Golgi","","COG6","ENSG00000133103","","Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network; COPI-mediated anterograde transport","",323.2,334.3,332.7,313.5,311.1,765.2,0.7124766153403367,-0.4890854315804088,0.42755617856636285,0.3690068132436047,0.5942209753073866,0.22605202217308906,5259]
["Q9Y2W1","Thyroid hormone receptor-associated protein 3 [OS=Homo sapiens]",38,42,191,41,955,108.6,10.15,496.99,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","THRAP3","ENSG00000054118","","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","Interactome of polycomb repressive complex 2 (PRC2)",29732.9,29436.6,29139.8,26341.1,28273.6,22863.1,1.1398013366409476,0.18878238963644414,0.08595452860739508,1.0657312370991938,0.31649453379921944,0.49963378631435473,1985]
["Q9Y2W2","WW domain-binding protein 11 [OS=Homo sapiens]",17,12,38,12,641,70,8.38,88.86,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","WBP11","ENSG00000084463","Spliceosome","mRNA Splicing - Major Pathway","",4795.2,4832.9,4755.4,6116.1,6297.7,6088.9,0.7773730320439719,-0.3633210350765667,3.8177520151488861E-5,4.418192284939255,0.009301316492907736,2.031455577774944,30]
["Q9Y2W6","tudor and KH domain-containing protein [OS=Homo sapiens]",27,12,19,12,561,62,5.02,53.9,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","mitochondrion;other cell component","nucleic acid binding activity","TDRKH","ENSG00000182134","","PIWI-interacting RNA (piRNA) biogenesis","",1973.9,2020.1,2008.8,2171.1,2042.3,2490.2,0.8954591562742408,-0.15930046545047505,0.15589292199846005,0.8071736026225347,0.40795609269127986,0.38938657643956676,2793]
["Q9Y2X0-1","Mediator of RNA polymerase II transcription subunit 16 [OS=Homo sapiens]",7,7,8,7,877,96.7,7.37,15.28,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","MED16","ENSG00000175221","Thyroid hormone signaling pathway","Transcriptional regulation of white adipocyte differentiation; Generic Transcription Pathway; PPARA activates gene expression","",761.5,737.8,751.5,807.2,817.6,1086.3,0.8302165172808085,-0.26844046002839395,0.16926413944567922,0.7714350424256946,0.4212296885285902,0.3754810270645219,2937]
["Q9Y2X3","Nucleolar protein 58 [OS=Homo sapiens]",52,27,199,27,529,59.5,8.92,613.24,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NOP58","ENSG00000055044","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; SUMOylation of RNA binding proteins; rRNA modification in the nucleus and cytosol","",27096.3,27284.7,27543.2,24997,25124,15352.5,1.251257378939571,0.32337857697586325,0.16569222213348542,0.7806978776023215,0.4181783327257061,0.3786384732434578,2896]
["Q9Y2X7-1","ARF GTPase-activating protein GIT1 [OS=Homo sapiens]",27,17,25,15,761,84.3,6.8,70.26,"developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","GIT1","ENSG00000108262","Endocytosis; Regulation of actin cytoskeleton; Epithelial cell signaling in Helicobacter pylori infection","RHOJ GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOU GTPase cycle; CDC42 GTPase cycle; RHOQ GTPase cycle; RHOV GTPase cycle; Ephrin signaling; Activation of RAC1 downstream of NMDARs","CAMKK2 pathway; Regulation of actin cytoskeleton",2117.8,2208.3,2094.8,2088.4,2070.2,1963.3,1.0488410460804654,0.06879605121578422,0.12874012695811723,0.8902860669238232,0.3736940381004285,0.427483830811694,2518]
["Q9Y2X9","Zinc finger protein 281 [OS=Homo sapiens]",1,1,2,1,895,96.9,8.48,4.27,"developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF281","ENSG00000162702","","","Mesodermal commitment pathway",69.6,68.5,76.1,95.8,122.9,102.6,0.6666666666666667,-0.5849625007211561,0.01357962107757102,1.8671123483335679,0.13376475802690915,0.873658291728622,742]
["Q9Y2Y0","ADP-ribosylation factor-like protein 2-binding protein [OS=Homo sapiens]",34,5,13,5,163,18.8,4.35,30.82,"signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","ARL2BP","ENSG00000102931","","Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane","Ciliopathies",1336,1214.9,1222.4,1387.7,1358.9,869.9,1.043356836720586,0.0612326559622748,0.7770140417064687,0.10957113283289037,0.8477676714185072,0.07172314874001781,6699]
["Q9Y2Y9","Krueppel-like factor 13 [OS=Homo sapiens]",9,2,2,1,288,31.2,9.54,6.01,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KLF13","ENSG00000169926; ENSG00000275746","","","15q13.3 copy number variation syndrome",64,70,89.3,195,197.1,225.9,0.36132686084142396,-1.4686235869692632,4.6870496724497147E-4,3.329100443886126,0.023956395843311162,1.6205785194672149,143]
["Q9Y2Z0-1","Protein SGT1 homolog [OS=Homo sapiens]",46,14,43,14,365,41,5.16,124.5,"cell cycle OR cell proliferation;other biological processes","cytosol;nucleus;other cell component","other molecular function","SUGT1","ENSG00000165416; ENSPTRG00000005906","NOD-like receptor signaling pathway","The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection","Nucleotide-binding oligomerization domain (NOD) pathway",5930.4,5914.2,5866.1,5475.8,5403.5,4255.8,1.1701739664752793,0.22672302717103335,0.0958113943278927,1.0185828395700107,0.3311042464031053,0.48003524939709896,2115]
["Q9Y2Z2-6","Isoform 7 of Protein MTO1 homolog, mitochondrial [OS=Homo sapiens]",10,6,7,6,732,81.5,8.16,15.6,"","","","MTO1","","","","",233.4,223.7,232.8,304.9,309.6,282.4,0.7692050395807785,-0.3785598801107743,1.5306938508428192E-3,2.8151116624598425,0.044046619511063645,1.3560874171958077,254]
["Q9Y2Z4","Tyrosine--tRNA ligase, mitochondrial [OS=Homo sapiens]",27,10,15,10,477,53.2,8.98,35.42,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;mitochondrion;nucleus","nucleic acid binding activity;other molecular function","YARS2","ENSG00000139131","Aminoacyl-tRNA biosynthesis","Mitochondrial tRNA aminoacylation","Orexin receptor pathway",1359.3,1331.4,1318.7,1303.9,1286.9,1083,1.091349556317709,0.12611326700888437,0.19509868256513782,0.7097456632380944,0.4423003321552706,0.35428273448717446,3224]
["Q9Y2Z9-1","Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial [OS=Homo sapiens]",6,3,4,3,468,50.8,7.3,4.76,"other metabolic processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","COQ6","ENSG00000119723","Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways; Biosynthesis of cofactors","Ubiquinol biosynthesis","Nephrotic syndrome",429,373.2,412.1,336.2,279.4,198.9,1.4908532842234505,0.5761382881122995,0.03655666639877333,1.437033414432364,0.20972737418260148,0.6783448805477226,1274]
["Q9Y303","N-acetylglucosamine-6-phosphate deacetylase [OS=Homo sapiens]",22,7,18,1,409,43.7,6.7,58.49,"other metabolic processes","cytosol","other molecular function","AMDHD2","ENSG00000162066","Amino sugar and nucleotide sugar metabolism; Metabolic pathways","Synthesis of UDP-N-acetyl-glucosamine","",102,112.4,121.1,116.2,133.1,132.4,0.8789625360230546,-0.18612642012801248,0.1198277630817658,0.9214425479207464,0.3635621089101811,0.4394213860351169,2409]
["Q9Y303-3","Isoform 3 of N-acetylglucosamine-6-phosphate deacetylase [OS=Homo sapiens]",19,8,18,2,594,63.6,7.53,56.95,"","","","AMDHD2","","","","",1617.7,1512.1,1550.2,1541.1,1527.1,2130.1,0.9002943269915166,-0.15153136602972953,0.43870121960077285,0.3578311582434489,0.6021534674294927,0.2202928084702513,5325]
["Q9Y305-1","Acyl-coenzyme A thioesterase 9, mitochondrial [OS=Homo sapiens]",34,14,39,14,439,49.9,8.6,116.05,"other metabolic processes","mitochondrion","other molecular function","ACOT9","ENSG00000123130","","Mitochondrial Fatty Acid Beta-Oxidation","VEGFA-VEGFR2 signaling pathway",2972.7,2860.9,2890.2,2837.9,2676.8,3382.1,0.9805548062224617,-0.02832982555548748,0.8026770326571473,0.09545916350007681,0.8664549448665027,0.06225401541352833,6771]
["Q9Y312","Protein AAR2 homolog [OS=Homo sapiens]",24,6,14,6,384,43.4,5.96,36.75,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","","AAR2","ENSG00000131043","","","Ciliary landscape",1151.2,1108.4,1152.7,1128.1,1185.6,1205,0.9697615596669226,-0.044298026940940205,0.2633794308121707,0.5794181452192871,0.5010516032811441,0.30011754386098904,3842]
["Q9Y314","nitric oxide synthase-interacting protein [OS=Homo sapiens]",45,8,17,8,301,33.2,8.82,55.24,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","NOSIP","ENSG00000142546","","NOSIP mediated eNOS trafficking","",1327.2,1251.6,1268.4,1297,1334,865.9,1.1001744402184792,0.1377322911004309,0.4851675128497561,0.31410828748899094,0.6354998837668221,0.19688452454259678,5580]
["Q9Y315","deoxyribose-phosphate aldolase [OS=Homo sapiens]",31,10,21,10,318,35.2,8.94,65.5,"other metabolic processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","DERA","ENSG00000023697","Pentose phosphate pathway; Metabolic pathways","Neutrophil degranulation; Pentose phosphate pathway","",2831.3,2861.4,2861.7,2670.1,2677.3,2588.8,1.0778962223734283,0.10821828507156891,2.3866784303933223E-3,2.6222060918074845,0.05627171821853158,1.2497098237577844,310]
["Q9Y316-1","Protein MEMO1 [OS=Homo sapiens]",39,9,21,9,297,33.7,7.14,62.18,"other biological processes","","other molecular function","LOC111154137; LOC114499315; MEMO1","ENSANAG00000021250; ENSCANG00000020056; ENSCATG00000030724; ENSCCAG00000037443; ENSCHIG00000006439; ENSCJAG00000003208; ENSDLEG00000015222; ENSECAG00000019946; ENSFCAG00000001385; ENSG00000162959; ENSHGLG00000018935; ENSMMUG00000003908; ENSMNEG00000040106; ENSMODG00000047380; ENSPANG00000022798; ENSPCOG00000018130; ENSPCTG00005009736; ENSPTRG00000050445; ENSRFEG00010015180; ENSSSCG00000008515; ENSSSCG00070008027; ENSVURG00010020209; ENSVVUG00000007616","","ERBB2 Regulates Cell Motility; ERBB2 Regulates Cell Motility","",2157.3,2135.8,2126.6,2141.8,2131.2,1889.4,1.041753213033883,0.05901354968855448,0.35943412591182033,0.4443806918580763,0.556707782642402,0.25437270731705264,4719]
["Q9Y320","Thioredoxin-related transmembrane protein 2 [OS=Homo sapiens]",40,11,38,11,296,34,8.69,125.59,"developmental processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","TMX2","ENSG00000213593","","","",4872.4,5281,5180.4,4534.8,4799.9,4497.3,1.1085743204164256,0.1487054937974486,0.03229595516001475,1.4908518665755621,0.2015808166221587,0.6955507997639523,1171]
["Q9Y333","U6 snRNA-associated Sm-like protein LSm2 [OS=Homo sapiens]",75,6,22,6,95,10.8,6.52,72.61,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LSM2","ENSG00000172850; ENSG00000204392; ENSG00000224979; ENSG00000225998; ENSG00000231502; ENSG00000236826","RNA degradation; Spliceosome","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease; mRNA Splicing - Minor Pathway","mRNA processing",2530.7,2633.3,2477.9,2644.8,2300,1727.3,1.1453515384961255,0.1957904673233311,0.2995056227839124,0.5235950199487801,0.5254648576398501,0.2794563236765343,4166]
["Q9Y365","START domain-containing protein 10 [OS=Homo sapiens]",12,2,4,2,291,33,7.12,6.11,"transport","other membranes;cytosol;cytoskeleton;other cell component","other molecular function","STARD10","ENSG00000214530","","Synthesis of PC","",14.5,12.3,15,17,12,3.9,1.2705167173252279,0.34541535834564113,0.48982645418585435,0.30995776352185594,0.6385128506588924,0.19483035773637744,5607]
["Q9Y371","Endophilin-B1 [OS=Homo sapiens]",28,12,35,11,365,40.8,6.04,97.7,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SH3GLB1","ENSG00000097033","Autophagy; Endocytosis","","Nanoparticle triggered autophagic cell death; Senescence and autophagy in cancer",3745.3,3650.5,3571.2,3687.5,3427,1953.7,1.2093910588650447,0.2742808181696214,0.30785161649335685,0.5116585616362423,0.5318098475419393,0.27424362508356404,4231]
["Q9Y375","Complex I intermediate-associated protein 30, mitochondrial [OS=Homo sapiens]",36,11,26,11,327,37.7,7.64,91.39,"cell organization and biogenesis;other metabolic processes","other membranes;cytosol;mitochondrion","other molecular function","NDUFAF1","ENSG00000137806","Thermogenesis","Complex I biogenesis","Mitochondrial immune response to SARS-CoV-2",2713.3,2717.5,2646.9,2697.6,2847.7,3446.4,0.89835070120222,-0.15464933576255652,0.2556675118728617,0.5923244550427291,0.4947508192424533,0.3056134779862812,3777]
["Q9Y376","Calcium-binding protein 39 [OS=Homo sapiens]",45,16,38,16,341,39.8,6.89,98.08,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","CAB39","ENSG00000135932","mTOR signaling pathway; AMPK signaling pathway","Neutrophil degranulation; Energy dependent regulation of mTOR by LKB1-AMPK","AMP-activated protein kinase (AMPK) signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias",6551.5,6478.6,6417.8,6320.1,6471.8,6590.3,1.003389708082674,0.004882045353339593,0.8141282085827628,0.08930719720472713,0.8755831484007377,0.057702605517762164,6796]
["Q9Y383","Putative RNA-binding protein Luc7-like 2 [OS=Homo sapiens]",40,20,182,14,392,46.5,10.01,519.86,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","LUC7L2","ENSG00000146963","","","",20205.9,19846,20230.2,20480.8,21202.6,18635.2,0.9993948798546388,-8.7326807556213919E-4,0.9882183750895872,0.005147075030877281,0.9924276042222854,3.3011643971209217E-3,7278]
["Q9Y385","ubiquitin-conjugating enzyme e2 j1 [OS=Homo sapiens]",33,9,26,9,318,35.2,6.74,93.82,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","UBE2J1","ENSG00000198833","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum; Parkinson disease; Pathways of neurodegeneration","Antigen processing: Ubiquitination & Proteasome degradation","Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway",1570.3,1677.7,1673.4,2608.3,2758.8,3543.6,0.5523022882601815,-0.8564699901928947,0.010395155167759868,1.9831690236005326,0.11670996792804435,0.9328920502847516,651]
["Q9Y388","RNA-binding motif protein, X-linked 2 [OS=Homo sapiens]",15,5,9,5,322,37.3,9.83,24.14,"RNA metabolism OR transcription;other metabolic processes","nucleus","","RBMX2","ENSG00000134597","","","",1274.3,1287.5,1228.4,1429.7,1465.7,1287.6,0.9060961032751614,-0.14226401992983448,0.08410493529060567,1.0751785189870013,0.31331446077422875,0.504019560146958,1962]
["Q9Y394","Dehydrogenase/reductase SDR family member 7 [OS=Homo sapiens]",40,9,16,9,339,38.3,8.32,51.28,"","","other molecular function","DHRS7","ENSG00000100612","","","",1573.1,1648.1,1643.6,1497.4,1495,1290.3,1.135918929647185,0.18385987360177547,0.056093755030510055,1.251085486457866,0.2568854984448609,0.5902604115886037,1596]
["Q9Y399","28S ribosomal protein S2, mitochondrial [OS=Homo sapiens]",12,5,13,5,296,33.2,9.26,31.26,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPS2","ENSG00000122140","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",2046,2008.3,2049.5,1887.4,1788.1,1304.1,1.2257611053096633,0.2936778323987167,0.1067160630641439,0.9717702049891458,0.34497465941434224,0.4622128054505325,2261]
["Q9Y3A0-1","Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial [OS=Homo sapiens]",15,4,6,4,265,29.6,9.17,14.49,"other metabolic processes","other membranes;mitochondrion;other cell component","","COQ4","ENSG00000167113","","","",182.5,150.4,192,188.1,200.5,285.5,0.7786678534342085,-0.360920027690286,0.20734262474089582,0.6833114080515788,0.4544129667859693,0.34254928442017357,3335]
["Q9Y3A3","MOB-like protein phocein [OS=Homo sapiens]",46,7,22,7,225,26,5.78,49.1,"","other membranes;ER/Golgi;other cell component","other molecular function","MOB4","ENSG00000115540","","","",1065.7,1120.9,1042.9,1157.1,1134.6,928.1,1.0030126094788498,4.3397430570281965E-3,0.968297387377963,0.013991239941497355,0.9794195411493954,0.009031235289527826,7226]
["Q9Y3A4","Ribosomal RNA-processing protein 7 homolog A [OS=Homo sapiens]",21,5,9,5,280,32.3,9.58,22.92,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","","RRP7A","ENSG00000189306","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",887.4,920.7,967,2353.5,2293.2,1679.8,0.4386469611949735,-1.1888678208231749,0.005437810477737347,2.2645759328108923,0.08385011979278958,1.0764963126010043,474]
["Q9Y3A5","Ribosome maturation protein SBDS [OS=Homo sapiens]",54,17,52,17,250,28.7,8.75,132.39,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;translation activity;nucleic acid binding activity","SBDS","ENSG00000126524","Ribosome biogenesis in eukaryotes","","",7248,7552.2,7056.5,7376.6,6836.8,6523.9,1.0539800263293677,0.07584752713773776,0.2645946119000328,0.5774190038594369,0.5016658932236938,0.29958542436243973,3855]
["Q9Y3A6-1","Transmembrane emp24 domain-containing protein 5 [OS=Homo sapiens]",36,7,15,7,229,26,4.84,29.15,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED5","ENSG00000117500","","WNT ligand biogenesis and trafficking","",2163.9,2140,2269.4,1839.6,1838.2,1107.8,1.3735581745235705,0.45791801439580504,0.0732909699434864,1.1349495307517568,0.2946555001743356,0.5306854477537325,1818]
["Q9Y3B2","Exosome complex component csl4 [OS=Homo sapiens]",28,4,6,4,195,21.4,8.24,17.07,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","EXOSC1","ENSG00000171311","RNA degradation","Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease","",705.4,695.9,695.2,739.7,595.9,337.1,1.2533628265678247,0.3258041100454625,0.296755872396123,0.5276006781897229,0.5247976461028945,0.28000812158745814,4133]
["Q9Y3B3-1","Transmembrane emp24 domain-containing protein 7 [OS=Homo sapiens]",33,6,21,6,224,25.2,6.89,52.45,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED7","ENSG00000134970; ENSPTRG00000017152","","COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic","Regulation of toll-like receptor signaling pathway",2557.5,2498.3,2611.6,2413.6,1963.2,2249.3,{"$f":"AVERAGE(S7106:U7106)/AVERAGE(V7106:X7106)","v":1.1571512654502647},{"$f":"LOG(Y7106,2)","v":0.2105774691563599},{"$f":"TTEST(S7106:U7106,V7106:X7106,2,2)","v":0.06265664522635744},{"$f":"-LOG10(AA7106)","v":1.20303286190699},{"$f":"AA7106*7309/AE7106","v":0.27082047306886253},{"$f":"-LOG10(AC7106)","v":0.5673185076207589},1691]
["Q9Y3B4","Splicing factor 3B subunit 6 [OS=Homo sapiens]",11,1,1,1,125,14.6,9.38,2.98,"RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus","nucleic acid binding activity","SF3B6","ENSG00000115128","Spliceosome","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","",44.5,44.6,38.7,52.7,55.7,129.9,0.53629878304658,-0.8988911152432766,0.2194874222199488,0.6585903620595894,0.4647258311140225,0.3328031872187885,3452]
["Q9Y3B6","ER membrane protein complex subunit 9 [OS=Homo sapiens]",8,1,3,1,208,23,5.91,12.27,"cell organization and biogenesis","other membranes;ER/Golgi;other cell component","","EMC9","ENSG00000100908; ENSG00000285377","","","",96.8,114.9,93.8,91.2,105.2,167.6,0.8392857142857143,-0.25276607037996673,0.4687980832707629,0.32901417264404575,0.6253778409611254,0.20385751119478257,5479]
["Q9Y3B7-1","39S ribosomal protein L11, mitochondrial [OS=Homo sapiens]",58,12,42,12,192,20.7,9.91,125.25,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL11","ENSG00000174547; ENSPPAG00000028194; ENSPTRG00000003924","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",5749.5,5985.9,5909.2,5465.8,6521.3,4421.4,1.075332906725173,0.10478336542373279,0.5365287378292865,0.2704070111697418,0.673448144391938,0.17169583939379404,5823]
["Q9Y3B8-1","Oligoribonuclease, mitochondrial [OS=Homo sapiens]",32,6,20,6,237,26.8,6.87,64.33,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","REXO2","ENSG00000076043; ENSPPAG00000039849; ENSPTRG00000004306","Ribosome biogenesis in eukaryotes","","",1816.5,1899.7,1659.9,2298.5,2291.8,2560.6,0.7518074647946413,-0.4115648547275758,0.006365271145473255,2.1961830917000813,0.08998794352468863,1.0458156729100505,517]
["Q9Y3B9","RRP15-like protein [OS=Homo sapiens]",16,5,12,5,282,31.5,5.52,20.14,"RNA metabolism OR transcription;other metabolic processes","other cell component","","RRP15","ENSG00000067533","","","",1823.2,1814.6,1919.7,2733.3,2804.3,1870,0.7502429936821642,-0.4145701539424317,0.11084184657919435,0.9552962476635851,0.35208303200666297,0.45335490444825555,2301]
["Q9Y3C0","WASH complex subunit 3 [OS=Homo sapiens]",17,2,3,2,194,21.2,4.46,8.94,"cell organization and biogenesis;transport","other cytoplasmic organelle;other cell component","","WASHC3","ENSG00000120860","Endocytosis","","",398.9,392.5,367.6,473,479.8,205,1.0010364484366903,1.4945046649552998E-3,0.9967029553863417,1.4342539833874608E-3,0.9979317672491468,8.9915221987038943E-4,7300]
["Q9Y3C1","nucleolar protein 16 [OS=Homo sapiens]",14,3,4,3,178,21.2,9.94,6.24,"other biological processes","nucleus;other cell component","","NOP16","ENSG00000048162","","","",279.2,275.5,434,533.5,442.7,562.8,0.6424301494476933,-0.6383884943141936,0.04466121145908118,1.3500695006363193,0.2306917276002999,0.6369679786126552,1415]
["Q9Y3C4","EKC/KEOPS complex subunit TPRKB [OS=Homo sapiens]",25,3,10,3,175,19.6,6.79,31.28,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","TPRKB","ENSG00000144034","","tRNA modification in the nucleus and cytosol","",1015.9,1002.2,966.9,1014.4,967.4,741.5,1.096096647449785,0.13237501239438024,0.3652273789617943,0.43743667339859704,0.5595151777052514,0.2521881280735502,4771]
["Q9Y3C6","Peptidyl-prolyl cis-trans isomerase-like 1 [OS=Homo sapiens]",34,5,30,5,166,18.2,7.99,62.77,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","PPIL1","ENSG00000137168","Spliceosome","mRNA Splicing - Major Pathway","",4177.2,4176.8,4245.1,4385.9,4618.2,5330.9,0.8789047785141263,-0.18622122417954234,0.11236634825849208,0.9493637328404212,0.3546138339470288,0.45024432601184683,2316]
["Q9Y3C8","ubiquitin-fold modifier-conjugating enzyme 1 [OS=Homo sapiens]",38,8,27,8,167,19.4,7.4,79.1,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes","","other molecular function","UFC1","ENSG00000143222","","","",4704,4891.7,4427.1,5314.4,5642.1,4971.8,0.8803701587740062,-0.18381785074648108,0.054525987882327445,1.2633964572860428,0.25432702324947754,0.59460749187066,1567]
["Q9Y3D0","Mitotic spindle-associated MMXD complex subunit MIP18 [OS=Homo sapiens]",13,1,2,1,163,17.7,5.19,7.54,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","","CIAO2B","ENSG00000166595","","Cytosolic iron-sulfur cluster assembly","",54.2,50.1,48.4,66.6,68,98.4,0.6553648068669529,-0.609629892744791,0.06362636536308161,1.196362884996406,0.27227465131075146,0.5649927894654193,1708]
["Q9Y3D2","Methionine-R-sulfoxide reductase B2, mitochondrial [OS=Homo sapiens]",16,1,1,1,182,19.5,8.63,5.54,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response","cytosol;mitochondrion;other cell component","cytoskeletal activity;other molecular function","MSRB2","ENSG00000148450","","Protein repair","Sulindac metabolic pathway; Methionine de novo and salvage pathway",66.5,67.4,62.4,61.5,71.3,129.9,0.7472401979444232,-0.420356027667461,0.35964521481199646,0.4441257137437598,0.5569167108179834,0.2542097504938747,4720]
["Q9Y3D3","28S ribosomal protein S16, mitochondrial [OS=Homo sapiens]",34,4,10,4,137,15.3,9.5,31.7,"protein metabolism;other metabolic processes","other membranes;cytosol;mitochondrion;translational apparatus","other molecular function","MRPS16","ENSG00000182180","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1002.7,1021.6,926.7,1015.8,1111.7,910.5,0.9713627386438446,-0.041917949070076344,0.678290767729553,0.16858409411203434,0.775841505686276,0.1102269903864615,6390]
["Q9Y3D6","mitochondrial fission 1 protein [OS=Homo sapiens]",20,3,14,3,152,16.9,8.79,36.07,"cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","FIS1","ENSG00000214253","Mitophagy","Class I peroxisomal membrane protein import","CAMKK2 pathway",934.2,1026.6,1075.3,810,942.1,613.5,1.2834376056814338,0.36001316099942177,0.09819141135054624,1.0079264976121214,0.3336499421483693,0.47670894611561115,2151]
["Q9Y3D8","Adenylate kinase isoenzyme 6 [OS=Homo sapiens]",47,5,11,5,172,20,4.58,41.12,"other metabolic processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","AK6","ENSG00000085231; ENSG00000279247","Purine metabolism; Metabolic pathways; Biosynthesis of cofactors; Ribosome biogenesis in eukaryotes","Interconversion of nucleotide di- and triphosphates","",963.3,918.1,844.8,1085.3,917.8,1281.6,0.8299692513775991,-0.26887020626729474,0.1677783415805721,0.7752641027393479,0.4201068511861601,0.3766402358433893,2919]
["Q9Y3D9","28S ribosomal protein S23, mitochondrial [OS=Homo sapiens]",19,4,5,4,190,21.8,8.9,13.39,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus","other molecular function","MRPS23","ENSG00000181610","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",992.4,929,896.1,989.6,990.3,417.1,1.1754276178556529,0.23318570141045045,0.5079647347574852,0.2941664373850788,0.6511249116700208,0.18633568847454707,5702]
["Q9Y3E0","vesicle transport protein GOT1B [OS=Homo sapiens]",25,4,27,4,138,15.4,10.36,67.71,"transport","other membranes;ER/Golgi;other cell component","","GOLT1B","ENSG00000111711","","","",1978.1,2051.9,2123.7,1868.5,1967.7,2015.4,1.0516269054617537,0.07262295832733534,0.17036421121873369,0.7686216331765136,0.42252867994493537,0.37414380714246576,2947]
["Q9Y3E1","Hepatoma-derived growth factor-related protein 3 [OS=Homo sapiens]",18,3,6,2,203,22.6,7.99,12.72,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;nucleus","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function","HDGFL3","ENSG00000166503","","","",157.8,180.3,184.5,165.9,180.7,340.5,0.7605879784601951,-0.39481295838128405,0.3868145880558836,0.4124971556006598,0.5716190505662057,0.2428933057419653,4946]
["Q9Y3E2","BolA-like protein 1 [OS=Homo sapiens]",9,1,1,1,137,14.3,7.96,2.23,"","mitochondrion","","BOLA1","ENSG00000178096","","","",48,65.2,57.3,39.9,54.3,19,1.5061837455830391,0.5908977810796527,0.16885347818725743,0.7724899889700861,0.4209243083460657,0.37579599305520345,2932]
["Q9Y3E5","Peptidyl-tRNA hydrolase 2, mitochondrial [OS=Homo sapiens]",56,7,11,7,179,19.2,8.73,36.93,"other biological processes","cytosol;mitochondrion","other molecular function","PTRH2","ENSG00000141378","","Ub-specific processing proteases","",1121.4,1081.2,1067.6,1101,1162.5,819.9,1.0605824738924565,0.08485681327698989,0.5907819123164586,0.22857280974025637,0.7104351755710754,0.14847554360020745,6078]
["Q9Y3E7","Charged multivesicular body protein 3 [OS=Homo sapiens]",9,2,2,2,222,25.1,5.12,5.28,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","CHMP3","ENSG00000115561","Endocytosis; Necroptosis","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","",81.9,94.5,101.5,73,85.2,107,1.0478883861236803,0.06748505908797423,0.7309850777278324,0.13609148860521375,0.8153166386559937,0.08867369467737948,6553]
["Q9Y3F4","Serine-threonine kinase receptor-associated protein [OS=Homo sapiens]",63,16,105,16,350,38.4,5.12,381.28,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","STRAP","ENSG00000023734","","Downregulation of TGF-beta receptor signaling","TGF-beta signaling pathway; Epithelial to mesenchymal transition in colorectal cancer",10723.2,10548.4,10491.9,11101.9,10678.4,10899.1,0.9719731696420375,-0.04101160467628681,0.0958568429253525,1.0183768787312215,0.33110475658856403,0.4800345802103967,2116]
["Q9Y3I0","tRNA-splicing ligase RtcB homolog [OS=Homo sapiens]",68,26,142,26,505,55.2,7.23,472.97,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","cytoskeletal activity;other molecular function","RTCB","ENSG00000100220","","tRNA processing in the nucleus","Unfolded protein response",16872.3,16510.6,16668.8,17112.9,16675.2,13862.5,1.0503897117769763,0.07092469068747245,0.47802101094626254,0.32055301397892805,0.6318002837262627,0.1994201833996533,5530]
["Q9Y3I1","F-box only protein 7 [OS=Homo sapiens]",5,2,4,2,522,58.5,6.55,8.54,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","FBXO7","ENSG00000100225","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",446.1,491.5,449.6,552.5,524.8,452.7,0.9066666666666667,-0.14135584924554137,0.22412397571360482,0.6495116822281805,0.4687044745323999,0.3291009004259077,3495]
["Q9Y3L3-1","SH3 domain-binding protein 1 [OS=Homo sapiens]",18,12,33,12,701,75.7,6.77,85.44,"cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","SH3BP1","ENSG00000100092","","RAC1 GTPase cycle","",3130.9,3153.8,3146.9,3053.2,3248.6,2645.7,1.054104498463258,0.07601789538283328,0.41525694885387887,0.38168309139036716,0.5857030179801237,0.23232253815620016,5182]
["Q9Y3L5","ras-related protein Rap-2c [OS=Homo sapiens]",46,8,43,4,183,20.7,4.94,126.77,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","RAP2C","ENSG00000123728","Tight junction","Neutrophil degranulation","",1287.3,1373.5,1333.4,1119.4,1273.1,966,1.1892809289861546,0.2500895451782077,0.08283259806405392,1.0817987166781748,0.3119131680835498,0.5059662901825646,1941]
["Q9Y3M8-4","Isoform 4 of StAR-related lipid transfer protein 13 [OS=Homo sapiens]",1,1,3,1,1078,120.6,6.95,6.05,"","","","STARD13","","","","",385.4,453.2,347.8,369.8,438,248.1,1.1235912491713231,0.16811729352648774,0.5311241931661692,0.27480391564118495,0.6698855440641123,0.17399939405682682,5795]
["Q9Y3P4","rhomboid domain-containing protein 3 [OS=Homo sapiens]",3,1,3,1,386,40.5,6.58,7.94,"protein metabolism;developmental processes;signal transduction;other biological processes","other membranes","other molecular function","RHBDD3","ENSG00000100263","","","",94.2,114.6,111.1,97.9,100.5,223.6,0.7580568720379147,-0.39962200647887364,0.46270609332951784,0.3346947812825505,0.6207633693365355,0.20707391830330632,5448]
["Q9Y3P9","Rab GTPase-activating protein 1 [OS=Homo sapiens]",31,26,56,23,1069,121.7,5.25,167.69,"cell cycle OR cell proliferation;transport;other biological processes","cytosol;cytoskeleton","enzyme regulator activity;cytoskeletal activity;other molecular function","RABGAP1","ENSG00000011454","","TBC/RABGAPs","",6025.5,6137.4,6039.4,5691.8,6178.7,5403.9,1.0537153244106885,0.07548515584222205,0.24787640347788623,0.6057648138013625,0.4895240834963173,0.3102259370125013,3701]
["Q9Y3Q3","Transmembrane emp24 domain-containing protein 3 [OS=Homo sapiens]",12,3,7,3,217,24.8,5.6,19.5,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED3","ENSG00000166557","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport","",948.4,961.2,966.6,867.8,797,536,1.3068884042166484,0.38613595402018286,0.08978550388789022,1.0467937756900485,0.32375049231208175,0.4897895624990843,2027]
["Q9Y3Q8","TSC22 domain family protein 4 [OS=Homo sapiens]",32,8,19,6,395,41,7.21,54.61,"stress response;other biological processes","nucleus","","TSC22D4","ENSG00000166925","","","",1753.9,1687.8,1777.8,1834.1,1933.2,1824.7,0.9333869814020028,-0.09945274971702985,0.04748495255891959,1.3234439915531433,0.2373922833468832,0.624533402291012,1462]
["Q9Y3R5-1","Protein dopey-2 [OS=Homo sapiens]",3,5,5,5,2298,258.1,6.29,14.93,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","","DOP1B","ENSG00000142197","","","",623.8,570.7,558.3,543.6,547.4,430.1,1.1523239760699495,0.20454638775133566,0.1498304138672411,0.8244000208553085,0.40291041021179735,0.39479151136781104,2718]
["Q9Y3S2","zinc finger protein 330 [OS=Homo sapiens]",27,8,24,8,320,36.2,6.16,60.9,"","nucleus;other cell component","other molecular function","ZNF330","ENSG00000109445","","","",2309.4,2101.7,2191.4,2946.2,2560.4,4084.6,0.688391442155309,-0.5386989324843169,0.0970138937601644,1.0131660641742106,0.33274263232897305,0.47789155200443956,2131]
["Q9Y3T6","R3H and coiled-coil domain-containing protein 1 [OS=Homo sapiens]",21,7,9,7,440,49.1,5.63,30.34,"","","nucleic acid binding activity","R3HCC1","ENSG00000104679","","","",1185.4,1217.9,1212.5,1403.8,1450.8,1583.1,0.8147914460193343,-0.29549726044790253,0.007402137082833366,2.130642876311047,0.09945261018093579,1.0023838141252541,544]
["Q9Y3T9","Nucleolar complex protein 2 homolog [OS=Homo sapiens]",24,16,48,16,749,84.9,5.62,133.65,"cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","other molecular function","NOC2L","ENSG00000188976","","Regulation of TP53 Activity through Phosphorylation","",5403.3,5328.6,5352.2,5637.9,5219.9,4016.2,1.0813567298641928,0.11284253371740186,0.4537447275598807,0.3431884083579323,0.6123375579274682,0.21300910215104724,5416]
["Q9Y3U8","60S ribosomal protein L36 [OS=Homo sapiens]",21,2,5,2,105,12.2,11.59,14.47,"protein metabolism;other metabolic processes","cytosol;translational apparatus;nucleus","other molecular function","RPL36","ENSG00000130255","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",392.3,476.5,447.5,417.6,415.4,464.6,1.0144112207151665,0.02064260877272112,0.8427242657853603,0.07431450062610201,0.8946218821532606,0.0483604833350715,6885]
["Q9Y3X0","coiled-coil domain-containing protein 9 [OS=Homo sapiens]",17,9,13,9,531,59.7,5.4,33.02,"","","","CCDC9","ENSG00000105321","","","IL-18 signaling pathway",2041.7,1874.8,2994.2,3671.6,3065.9,1727.5,0.8163851151801536,-0.2926782163525234,0.4836655748156587,0.3154548226790383,0.6342145113612575,0.19776382517235075,5574]
["Q9Y3Z3","deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [OS=Homo sapiens]",60,33,158,33,626,72.2,7.14,474.84,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","plasma membrane;other membranes;nucleus;other cell component","nucleic acid binding activity;other molecular function","SAMHD1","ENSG00000101347","Human immunodeficiency virus 1 infection","Interferon alpha/beta signaling; Nucleotide catabolism","",20784.6,20614.3,20617.3,18719.7,18668.2,15829.7,1.1653325215718107,0.22074167914762027,0.03743223915378198,1.4267541931087793,0.2117586965750716,0.6741587448838716,1292]
["Q9Y448","Small kinetochore-associated protein [OS=Homo sapiens]",3,1,1,1,316,35.4,6.3,0,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KNSTRN","ENSG00000128944","","","Overview of leukocyte-intrinsic Hippo pathway functions",142.5,132.8,157.1,182.9,219.5,132.7,0.8080732573350776,-0.3074420058667121,0.26035212271150593,0.5844388770697733,0.4981449384550777,0.30264427809750905,3820]
["Q9Y450-1","HBS1-like protein [OS=Homo sapiens]",41,23,81,23,684,75.4,6.61,246.97,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol","nucleic acid binding activity;other molecular function","HBS1L","ENSG00000112339","mRNA surveillance pathway; Legionellosis","mRNA decay by 3' to 5' exoribonuclease","",7983.6,7918,7999.9,8128.4,7925.3,7937.2,0.99627358706843,-0.0053861191530586,0.6938704488659787,0.15872160821187387,0.7867668493269374,0.1041539475042166,6446]
["Q9Y478","5'-AMP-activated protein kinase subunit beta-1 [OS=Homo sapiens]",24,4,7,4,270,30.4,6.4,23.12,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","PRKAB1","ENSG00000111725","FoxO signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Apelin signaling pathway; Tight junction; Circadian rhythm; Thermogenesis; Insulin signaling pathway; Adipocytokine signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Insulin resistance; Non-alcoholic fatty liver disease; Alcoholic liver disease; Hypertrophic cardiomyopathy","Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Lipophagy","AMP-activated protein kinase (AMPK) signaling; Target of rapamycin (TOR) signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Angiopoietin-like protein 8 regulatory pathway; Leptin and adiponectin; Lipid metabolism pathway; Genotoxicity pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; Malignant pleural mesothelioma",291.1,282.8,304.8,284,271.2,528.7,0.8106836424024357,-0.3027890615530764,0.4613119857756529,0.3360052614363806,0.6198031808886484,0.20774619925058754,5440]
["Q9Y483","Metal-response element-binding transcription factor 2 [OS=Homo sapiens]",8,3,3,3,593,67.1,8.72,9.82,"","","","","","","","",232.5,224.8,227.7,283,283.3,305.6,0.785640555109531,-0.34805869076268925,1.3407053382420114E-3,2.872666661400591,0.041173173601726315,1.3853856565731297,238]
["Q9Y484-1","WD repeat domain phosphoinositide-interacting protein 4 [OS=Homo sapiens]",3,1,3,1,360,39.8,7.14,9.19,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response","other membranes;cytosol;other cell component","other molecular function","WDR45","ENSCANG00000035794; ENSCSAG00000012964; ENSG00000196998; ENSGGOG00000000589; ENSMFAG00000032970; ENSMLEG00000042347; ENSMMUG00000010620","","Macroautophagy","Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway",360.4,339,341.5,393.7,394.5,803.6,0.6539138082673703,-0.6128276068398291,0.25022002280510347,0.6016779406624341,0.4912323789101534,0.30871301499685344,3723]
["Q9Y485","DmX-like protein 1 [OS=Homo sapiens]",10,21,31,21,3027,337.6,6.34,93.99,"other biological processes","other cell component","","DMXL1","ENSG00000172869","","","",1800.4,1712.8,1851.1,2034.3,1931.5,1955.9,0.9058716247023656,-0.14262148118084328,0.021800640146100995,1.6615307537422983,0.17005429970955407,0.7694123827461036,937]
["Q9Y487","V-type proton ATPase 116 kDa subunit a isoform 2 [OS=Homo sapiens]",11,8,18,7,856,98,6.61,37.74,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ATP6V0A2","ENSG00000185344","Oxidative phosphorylation; Metabolic pathways; Lysosome; Phagosome; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Tuberculosis; Human papillomavirus infection; Rheumatoid arthritis","ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","",731.4,778,732.4,784.2,770.8,1132,0.8343133606252328,-0.2613387460974171,0.28118527045131764,0.5510074330450276,0.5149544329062091,0.28823119894507787,3991]
["Q9Y490","Talin-1 [OS=Homo sapiens]",70,136,676,115,2541,269.6,6.07,2295.38,"cell adhesion;cell organization and biogenesis;signal transduction","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","TLN1","ENSG00000137076","Rap1 signaling pathway; Focal adhesion; Platelet activation; Shigellosis; Human T-cell leukemia virus 1 infection","Platelet degranulation ; p130Cas linkage to MAPK signaling for integrins; Signaling by BRAF and RAF1 fusions; XBP1(S) activates chaperone genes; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Smooth Muscle Contraction; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins","Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion",74545.8,74537.3,74732.7,73253.2,73499.4,77350.4,0.9987184464286513,-1.8500767216063504E-3,0.9459977374819415,0.024109902287724198,0.9646062309229227,0.015649937057820026,7168]
["Q9Y496","kinesin-like protein KIF3A [OS=Homo sapiens]",11,7,14,7,699,80,6.54,27.19,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF3A","ENSG00000131437","Hedgehog signaling pathway","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Hedgehog 'off' state; Activation of SMO","Hedgehog signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Insulin signaling",940.4,967.3,906.5,878.7,984.9,1451.3,0.8489547195993847,-0.23624048757726535,0.39846648233656773,0.39960820412604015,0.5767111919599948,0.23904162036072854,5050]
["Q9Y4A5","Transformation/transcription domain-associated protein [OS=Homo sapiens]",9,29,55,29,3859,437.3,8.19,157.22,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","ER/Golgi;nucleus","other molecular function","TRRAP","ENSG00000196367","Human T-cell leukemia virus 1 infection","Ub-specific processing proteases; HATs acetylate histones; Formation of the beta-catenin:TCF transactivating complex","Rett syndrome causing genes",3307.3,3225.1,3374.4,4027.6,3916.3,5737.7,0.7240965968892528,-0.4657459244336559,0.10033106386556202,0.9985645826654578,0.33731359052133986,0.47196616053176055,2174]
["Q9Y4B4","Helicase ARIP4 [OS=Homo sapiens]",5,5,5,5,1467,162.7,6.09,13.39,"cell organization and biogenesis","nucleus","nucleic acid binding activity;other molecular function","RAD54L2","ENSG00000164080","","","",160.8,174.9,157.6,213.9,197.5,1260.7,0.2950182405358532,-1.7611239379821146,0.32651280419834977,0.4860997831985433,0.5400502570458788,0.26756582287686365,4419]
["Q9Y4B5","Microtubule cross-linking factor 1 [OS=Homo sapiens]",11,17,21,15,1905,209.4,6.43,59.89,"cell organization and biogenesis;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MTCL1","ENSG00000168502","","","",1625.8,1623.6,1607.1,1862.9,1685.3,2081,0.8627336033539402,-0.21301294504401178,0.08784747433447412,1.0562707202058959,0.31991887887925824,0.4949601308094086,2007]
["Q9Y4B6","DDB1- and CUL4-associated factor 1 [OS=Homo sapiens]",14,17,24,17,1507,168.9,5.06,59.02,"protein metabolism;DNA metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","kinase activity;other molecular function","DCAF1","ENSG00000145041","Human immunodeficiency virus 1 infection","Antigen processing: Ubiquitination & Proteasome degradation","Hippo-Merlin signaling dysregulation",1890.6,1901.9,1888.9,2579.6,2545.3,2725.4,0.7237175649338242,-0.4665013080310084,1.9849277989736493E-4,3.702255285917297,0.017910910225553585,1.746882342911974,81]
["Q9Y4C1","Lysine-specific demethylase 3A [OS=Homo sapiens]",4,4,5,4,1321,147.2,8.07,17.37,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KDM3A","ENSG00000115548","Thermogenesis","NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; HDMs demethylate histones","Thermogenesis; Male infertility; Vitamin D-sensitive calcium signaling in depression",317,340,343.2,360.8,345.1,322.8,0.9722951297754447,-0.04053379994921759,0.5282181494732737,0.27718668059847196,0.6677181692321269,0.17540680604913803,5782]
["Q9Y4C2-1","TRPM8 channel-associated factor 1 [OS=Homo sapiens]",12,8,10,8,921,102.1,6.54,20.97,"other biological processes","plasma membrane;other membranes","other molecular function","TCAF1","ENSG00000198420","","","",864.1,782.9,809.1,703.6,754.2,665.7,1.156628208146927,0.2099251924816884,0.03413128726609714,1.4668473319375865,0.2056599988688409,0.6868501709201866,1213]
["Q9Y4C8","Probable RNA-binding protein 19 [OS=Homo sapiens]",6,5,6,5,960,107.3,6.54,18.91,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","RBM19","ENSG00000122965","","","",286.5,281.3,302.5,429.6,476.6,568.1,0.5903140473445023,-0.7604454217566007,0.008094054058199789,2.09183389938855,0.10470697541837568,0.9800243853240157,565]
["Q9Y4D1","Disheveled-associated activator of morphogenesis 1 [OS=Homo sapiens]",8,9,12,9,1078,123.4,7.23,24.91,"cell-cell signaling;cell organization and biogenesis;signal transduction","plasma membrane;other membranes;cytosol;cytoskeleton","cytoskeletal activity;other molecular function","DAAM1","ENSG00000100592","Wnt signaling pathway","RHO GTPases Activate Formins; RHOA GTPase cycle; PCP/CE pathway; RHOC GTPase cycle; CDC42 GTPase cycle; RHOB GTPase cycle","Physico-chemical features and toxicity-associated pathways; Wnt signaling; Genotoxicity pathway",1494.3,1338.3,1443.9,1127.9,1187.2,1162.8,1.229621323212283,0.29821408854233117,0.005602441246345325,2.2516226892813997,0.08530883972820412,1.0690059647730141,480]
["Q9Y4D8-1","Probable E3 ubiquitin-protein ligase HECTD4 [OS=Homo sapiens]",1,2,2,1,3996,439.1,6.19,7.94,"protein metabolism;other metabolic processes;other biological processes","other membranes","other molecular function","HECTD4","","","","",16.5,15.4,14,18.2,16.3,26.2,0.7561779242174629,-0.4032023628418742,0.18881060224101126,0.7239736225088874,0.43740624145152185,0.3591150242050676,3155]
["Q9Y4D8-5","Isoform 5 of Probable E3 ubiquitin-protein ligase HECTD4 [OS=Homo sapiens]",3,3,3,2,1321,145,5.78,9.3,"","","","HECTD4","","","","",102.2,90.2,112.5,111.9,93.2,410,0.49569175743781496,-1.0124848255938623,0.37151733146541577,0.43002092138059983,0.5631315171465624,0.24939016553806173,4822]
["Q9Y4E1","WASH complex subunit 2C [OS=Homo sapiens]",31,32,65,7,1318,144.6,4.79,199.88,"","","","","","","","",334,360.5,409.8,451,478.4,851.4,0.6201145552560646,-0.6893933422367423,0.16038629765765572,0.7948327377093534,0.41247834256854526,0.38459884941683137,2842]
["Q9Y4E5","E3 SUMO-protein ligase ZNF451 [OS=Homo sapiens]",13,11,16,11,1061,121.4,6.77,39.08,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","ZNF451","ENSG00000112200","","","",954.8,890.2,871.6,1007.2,845,1862.8,0.7312516823687752,-0.4515600561350047,0.3526664379289235,0.4526358687017012,0.5548082210121614,0.25585711228194485,4646]
["Q9Y4E6-1","WD repeat-containing protein 7 [OS=Homo sapiens]",5,5,8,5,1490,163.7,6.92,26.64,"","ER/Golgi","","WDR7","ENSG00000091157","","","",482.9,522.2,547.3,513.2,514.9,772.1,0.8623486279302301,-0.21365685886307334,0.4012350231252463,0.39660116516764315,0.5781992870706674,0.23792244815734648,5072]
["Q9Y4E8-3","Isoform 3 of Ubiquitin carboxyl-terminal hydrolase 15 [OS=Homo sapiens]",36,27,68,26,956,109.7,5.16,185.84,"","","","USP15","","","","",6948.3,6865.9,6836,6525.1,6498.2,6906.4,1.0361520745420154,0.05123576082998745,0.15221067200841337,0.8175548966332492,0.40381408410507924,0.3938185379370801,2755]
["Q9Y4F1","FERM, RhoGEF and pleckstrin domain-containing protein 1 [OS=Homo sapiens]",6,5,7,5,1045,118.6,8.15,21.83,"cell-cell signaling;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","FARP1","ENSG00000152767","","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOF GTPase cycle","",304.2,311.4,307.2,281.2,288.3,566.1,0.8126100739697076,-0.299364845041409,0.49173664058705996,0.3082674300830199,0.6397477938858707,0.1939912030646062,5618]
["Q9Y4F3-1","Meiosis regulator and mRNA stability factor 1 [OS=Homo sapiens]",1,2,2,2,1742,192.7,7.87,4.99,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","ER/Golgi;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","MARF1","ENSG00000166783; ENSG00000277140","","","",187.2,192.8,181.5,240,228.1,183,0.8623867301489786,-0.21359311588733307,0.16612861342671542,0.7795555597032884,0.4187013915640907,0.3780955957182715,2900]
["Q9Y4G6","Talin-2 [OS=Homo sapiens]",8,22,62,2,2542,271.4,5.57,173.61,"cell adhesion;cell organization and biogenesis","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","TLN2","ENSG00000171914","Rap1 signaling pathway; Focal adhesion; Platelet activation; Shigellosis; Human T-cell leukemia virus 1 infection","","Focal adhesion",455.8,423.5,480.1,480.9,430.4,362.1,{"$f":"AVERAGE(S7170:U7170)/AVERAGE(V7170:X7170)","v":1.0675357311135543},{"$f":"LOG(Y7170,2)","v":0.09428435859295974},{"$f":"TTEST(S7170:U7170,V7170:X7170,2,2)","v":0.49394834227032314},{"$f":"-LOG10(AA7170)","v":0.3063184677565718},{"$f":"AA7170*7309/AE7170","v":0.6415973758048323},{"$f":"-LOG10(AC7170)","v":0.19273742102659153},5627]
["Q9Y4G8","rap guanine nucleotide exchange factor 2 [OS=Homo sapiens]",6,7,11,5,1499,167.3,6.67,18.79,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","RAPGEF2","ENSG00000109756","MAPK signaling pathway; Rap1 signaling pathway; Tight junction","RAF/MAP kinase cascade","MAPK signaling pathway; Genotoxicity pathway",508.3,546.8,586.6,543.4,520.3,641.7,0.962648059106368,-0.05491964488223805,0.6513422023250445,0.18619078173209283,0.7557803074763852,0.12160442819799244,6299]
["Q9Y4H2","Insulin receptor substrate 2 [OS=Homo sapiens]",1,2,3,2,1338,137.2,8.65,4.13,"other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;other molecular function","IRS2","ENSG00000185950","cGMP-PKG signaling pathway; FoxO signaling pathway; Autophagy; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Regulation of lipolysis in adipocytes; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; Growth hormone synthesis, secretion and action; Alzheimer disease; MicroRNAs in cancer","Growth hormone receptor signaling; Interleukin-7 signaling; Signaling by Leptin; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); RAF/MAP kinase cascade; PI3K Cascade; PI3K/AKT activation; Erythropoietin activates Phospholipase C gamma (PLCG); Erythropoietin activates STAT5; Erythropoietin activates RAS; SOS-mediated signalling; IRS activation; Signal attenuation","Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Farnesoid X receptor pathway; Nuclear receptors meta-pathway; Transcription factor regulation in adipogenesis; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; Nonalcoholic fatty liver disease; Insulin signaling; FOXA2 pathway; Alzheimer's disease; EPO receptor signaling; Interferon type I signaling pathways",247.7,239.8,232.6,347.4,334,420.8,0.6533297042279077,-0.6141168602178287,0.009585876058433942,2.018368190562904,0.11337082218623572,0.9454987037677467,618]
["Q9Y4I1-1","Unconventional myosin-Va [OS=Homo sapiens]",33,53,123,1,1855,215.3,8.48,353.17,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYO5A","ENSG00000197535","Pathogenic Escherichia coli infection","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Insulin processing; Translocation of SLC2A4 (GLUT4) to the plasma membrane","Joubert syndrome",120.2,132.7,97.5,118.4,109.5,173.9,0.8720756595321055,-0.1974747891321185,0.4911189737198311,0.30881328716212936,0.6392855884093046,0.194305085875633,5615]
["Q9Y4I1-3","Isoform 3 of Unconventional myosin-Va [OS=Homo sapiens]",32,53,122,1,1880,218.5,8.51,350.7,"","","","MYO5A","","","","",11418.6,11340,11246.6,11176,11246,10427.1,1.0351942671184295,0.049901532853883684,0.22206186553148588,0.653526016018016,0.4661258400831793,0.33149682091535543,3482]
["Q9Y4J8-1","Dystrobrevin alpha [OS=Homo sapiens]",11,7,7,7,743,83.8,6.89,19.38,"cell-cell signaling;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","other molecular function","DTNA","ENSG00000134769","","","",546.8,534,549,578,597.4,532.9,0.9540478838611484,-0.06786641767610047,0.25420041722437986,0.5948237409649485,0.4938731657344477,0.30638457029533567,3762]
["Q9Y4K3","TNF receptor-associated factor 6 [OS=Homo sapiens]",20,7,9,7,522,59.5,6.44,27.18,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","TRAF6","ENSG00000175104","MAPK signaling pathway; NF-kappa B signaling pathway; Ubiquitin mediated proteolysis; Autophagy; Endocytosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; IL-17 signaling pathway; Neurotrophin signaling pathway; Alcoholic liver disease; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Yersinia infection; Leishmaniasis; Chagas disease; Toxoplasmosis; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis","Ub-specific processing proteases; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; TRAF6 mediated NF-kB activation; activated TAK1 mediates p38 MAPK activation; Ovarian tumor domain proteases; NRIF signals cell death from the nucleus; Regulated proteolysis of p75NTR; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; PIP3 activates AKT signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; TICAM1,TRAF6-dependent induction of TAK1 complex; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway; TRAF6 mediated IRF7 activation; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling","Regulation of toll-like receptor signaling pathway; IL-1 signaling pathway; RANKL/RANK signaling pathway; IL-17 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Melatonin metabolism and effects; Photodynamic therapy-induced NF-kB survival signaling; Interleukin-1 induced activation of NF-kB; TGF-beta signaling pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor (RLR) pathway; MYD88 distinct input-output pathway; ApoE and miR-146 in inflammation and atherosclerosis; Oxidative damage response; Fibrin complement receptor 3 signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; miRNAs involvement in the immune response in sepsis; Signal transduction through IL1R; Interactions between immune cells and microRNAs in tumor microenvironment; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; 16p11.2 proximal deletion syndrome; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Modulators of TCR signaling and T cell activation; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; T-cell receptor (TCR) signaling pathway; Toll-like receptor signaling pathway",939.5,917.7,915.3,910.3,853.5,560.1,1.1930375661603339,0.25463947108003515,0.24124371335415346,0.6175439952532883,0.48294995916338196,0.31609786631904274,3651]
["Q9Y4K4","mitogen-activated protein kinase kinase kinase kinase 5 [OS=Homo sapiens]",2,1,1,1,846,95,7.64,3.44,"","","","","","","","",69.5,71,82.6,81.3,95.1,119.7,0.7534616683552854,-0.4083939769334133,0.11182424988457865,0.9514640063865231,0.35351359965674106,0.4515938742510415,2312]
["Q9Y4L1","Hypoxia up-regulated protein 1 [OS=Homo sapiens]",63,51,778,51,999,111.3,5.22,2458.55,"stress response;transport;other biological processes","non-structural extracellular;ER/Golgi;other cell component","other molecular function","HYOU1","ENSG00000149428; ENSG00000280682","Protein processing in endoplasmic reticulum","XBP1(S) activates chaperone genes; Scavenging by Class F Receptors","VEGFA-VEGFR2 signaling pathway",75318.5,75903.6,74892.7,68812.9,71997.1,62815.2,1.1104460548105046,0.15113930882570495,0.05040056219598274,1.2975646191645678,0.24607729398158842,0.6089284576236472,1497]
["Q9Y4L5","E3 ubiquitin-protein ligase RNF115 [OS=Homo sapiens]",3,1,1,1,304,33.7,5.69,1.74,"protein metabolism;other metabolic processes;other biological processes","cytosol","other molecular function","RNF115","ENSG00000265491","","Antigen processing: Ubiquitination & Proteasome degradation","",54.1,51.2,60.4,97.7,110.1,177.6,0.42994291645044114,-1.2177829690742692,0.04271298484077295,1.369440078430764,0.22524473751891014,0.6473453468225792,1386]
["Q9Y4P1-1","Cysteine protease ATG4B [OS=Homo sapiens]",23,6,17,6,393,44.3,5.07,57.73,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol","other molecular function","ATG4B","ENSG00000168397","Autophagy; Autophagy","Macroautophagy","",1350.3,1321,1249.5,1364.8,1383.3,1917.9,0.84029147021003,-0.25103825546180514,0.2479550238277461,0.60562708802395,0.4894148714979736,0.31032283818941964,3703]
["Q9Y4P3","Transducin beta-like protein 2 [OS=Homo sapiens]",37,17,53,17,447,49.8,9.44,156.95,"stress response;signal transduction","other membranes;ER/Golgi","other molecular function","TBL2","ENSG00000106638","","","7q11.23 copy number variation syndrome",7194,7625.3,7380.8,6861.3,6903.2,6922.4,1.0731477408408219,0.10184870638877208,0.016161022631546267,1.7915311615573652,0.14618925051234116,0.8350845604479784,808]
["Q9Y4P8-1","WD repeat domain phosphoinositide-interacting protein 2 [OS=Homo sapiens]",28,8,18,1,454,49.4,6.46,61,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","WIPI2","ENSG00000157954","Autophagy; Autophagy; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis","Macroautophagy","Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Alzheimer's disease",952.5,933.7,954.2,982.1,906.8,1595.2,0.8152464050974426,-0.29469192059350746,0.3809166898719361,0.4191699983012733,0.5679559539522605,0.24568534333335945,4902]
["Q9Y4P8-6","Isoform 6 of WD repeat domain phosphoinositide-interacting protein 2 [OS=Homo sapiens]",28,8,16,1,443,48.2,6.3,47.61,"","","","WIPI2","","","","",36.5,41.8,36.6,34.5,40.8,48.8,0.9258662369057213,-0.11112431748424315,0.5323492132767101,0.2738033834110136,0.6709674771235514,0.17329853027525607,5799]
["Q9Y4R8","telomere length regulation protein TEL2 homolog [OS=Homo sapiens]",16,9,19,9,837,91.7,5.76,60.21,"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TELO2","ENSG00000100726","Fanconi anemia pathway; mTOR signaling pathway","","Fragile X syndrome; Malignant pleural mesothelioma",776.6,792.2,815.5,872.8,862.6,1042.5,0.8583102343496887,-0.2204288939448001,0.09185123652511329,1.0369149927341261,0.3263688321643427,0.4862913225448772,2057]
["Q9Y4W2","Ribosomal biogenesis protein LAS1L [OS=Homo sapiens]",42,26,58,26,734,83,4.73,167.39,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","LAS1L","ENSG00000001497","","Major pathway of rRNA processing in the nucleolus and cytosol","",5821.5,6134.3,5620.2,5615.1,6194.5,5392.5,1.0217357183134619,0.031022077699316253,0.6813282755931316,0.16664358716620462,0.777976623388564,0.10903345247802211,6401]
["Q9Y4W6","AFG3-like protein 2 [OS=Homo sapiens]",41,33,106,33,797,88.5,8.66,305.32,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;mitochondrion","other molecular function","AFG3L2","ENSG00000141385","Spinocerebellar ataxia","Processing of SMDT1","Ciliary landscape",12465.3,13209.2,13505.5,11146.1,11958.6,9982.4,1.1841472960761144,0.24384854895787728,0.03563655247724127,1.4481043167712575,0.2088753504860918,0.6801128083658272,1247]
["Q9Y4X4-1","Krueppel-like factor 12 [OS=Homo sapiens]",4,2,2,1,402,44.2,9.7,3.52,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","KLF12","ENSCANG00000041690; ENSG00000118922; ENSGGOG00000004142; ENSMFAG00000002684; ENSMLEG00000030485; ENSMMUG00000019097; ENSMNEG00000039444; ENSNLEG00000016131; ENSPANG00000007736; ENSPPAG00000031325; ENSRBIG00000037086; ENSRROG00000027231","","","",22.8,36.9,30.1,44.3,53.6,6.6,0.8593301435406699,-0.21871559222709802,0.7593044280040996,0.11958406745760423,0.8350520710625885,0.07828644251632355,6646]
["Q9Y4X5","E3 ubiquitin-protein ligase ARIH1 [OS=Homo sapiens]",38,15,49,15,557,64.1,5.08,160.36,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","ARIH1","ENSG00000166233","","ISG15 antiviral mechanism","",5510.8,5384.9,5432.4,5067.9,5179.7,4156.1,1.1336045599394602,0.18091746664028288,0.12069540576114293,0.9183092608931899,0.3651335764520669,0.4375482289583112,2416]
["Q9Y4Y9","U6 snRNA-associated Sm-like protein LSm5 [OS=Homo sapiens]",25,1,2,1,91,9.9,4.54,4.63,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LSM5","ENSG00000106355","RNA degradation; Spliceosome","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease","",17,24.1,16.3,19,16.5,4.1,1.4494949494949496,0.5355503065960783,0.32057352518620097,0.4940723470483411,0.5376484386383531,0.2695016110746049,4358]
["Q9Y4Z0","U6 snRNA-associated Sm-like protein LSm4 [OS=Homo sapiens]",12,2,4,2,139,15.3,9.99,6.58,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LSM4","ENSG00000130520","RNA degradation; Spliceosome","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease","Ciliary landscape",440,418.4,462.6,525.8,525.5,843.3,0.6972448010134066,-0.5202628230093788,0.14747106332674445,0.8312931882986095,0.399357540516923,0.39863811097115326,2699]
["Q9Y508-1","E3 ubiquitin-protein ligase RNF114 [OS=Homo sapiens]",18,4,6,4,228,25.7,7.25,19.78,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus","other molecular function","RNF114","ENSG00000124226; ENSPPAG00000043607; ENSPTRG00000013613","","Antigen processing: Ubiquitination & Proteasome degradation","",1060.9,1009,1007,879,1014.2,967.6,1.0755383109619687,0.10505891485901922,0.17229832374660828,0.7637189476891711,0.42301929736780647,0.373639820451923,2977]
["Q9Y512","sorting and assembly machinery component 50 homolog [OS=Homo sapiens]",42,16,73,16,469,51.9,6.9,220.8,"cell organization and biogenesis;transport","other membranes;mitochondrion","","SAMM50","ENSG00000100347","","RAC2 GTPase cycle; Mitochondrial protein import; Cristae formation","",7304.4,7433.2,7533.4,6283.9,6496.4,4590.5,1.2820940889308496,0.3585021407811373,0.054515235769138505,1.2634821053241978,0.2544392453618348,0.5944159011621496,1566]
["Q9Y519","Transmembrane protein 184B [OS=Homo sapiens]",2,1,1,1,407,45.5,6.89,2.07,"","other membranes","","TMEM184B","ENSG00000198792","","","",57.9,52,43.9,46.4,60.4,34.5,1.0884642604387829,0.12229403762788733,0.6501959760401552,0.1869557226112913,0.7551696152673597,0.12195549247480392,6293]
["Q9Y520-7","Isoform 7 of Protein PRRC2C [OS=Homo sapiens]",23,56,122,54,2898,316.9,9.13,331.37,"","","","PRRC2C","","","","",14253.6,14500.6,14771.1,20416.6,21211.3,19705.6,0.7096497020388534,-0.4948210390619363,2.0768907190106591E-4,3.682586354393762,0.018071421744343934,1.7430076785716708,84]
["Q9Y535","DNA-directed RNA polymerase III subunit RPC8 [OS=Homo sapiens]",27,3,6,3,204,22.9,4.58,24.95,"RNA metabolism OR transcription;other metabolic processes;stress response","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","POLR3H","ENSG00000100413","RNA polymerase; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway",396.9,384.3,402,428.3,476.3,650.8,0.7607046418927608,-0.3945916863476283,0.1412732843700119,0.8499399580924318,0.39112364979561254,0.4076859230782899,2640]
["Q9Y547","Intraflagellar transport protein 25 homolog [OS=Homo sapiens]",42,4,11,4,144,16.3,5.03,43.54,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","other molecular function","HSPB11","ENSG00000081870","","Intraflagellar transport","Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); GDNF/RET signaling axis",681.2,673.3,678.1,737.8,630.3,562.4,1.052887852887853,0.07435177758025664,0.5419482828422232,0.26604215543188925,0.6773426811377923,0.16919155749772033,5848]
["Q9Y548","Protein YIPF1 [OS=Homo sapiens]",8,3,3,3,306,34.3,5.31,9.76,"transport","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle","other molecular function","YIPF1","ENSG00000058799","","","",452.4,476.1,471.4,407.1,437.9,248.1,1.2806696551093224,0.3568983848151072,0.15944434257492668,0.7973908858414058,0.41194015548962143,0.3851658714144237,2829]
["Q9Y570","Protein phosphatase methylesterase 1 [OS=Homo sapiens]",38,11,21,11,386,42.3,5.97,56.27,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","nucleus","enzyme regulator activity;other molecular function","PPME1","ENSG00000214517","","Cyclin A/B1/B2 associated events during G2/M transition","",2477.1,2376.6,2436.5,2407.3,2241.3,2353.2,1.0411894084378301,0.05823254102683164,0.166568867997536,0.7784061657161466,0.41908841865541846,0.3776943405585232,2905]
["Q9Y572-1","Receptor-interacting serine/threonine-protein kinase 3 [OS=Homo sapiens]",7,3,3,3,518,56.9,6.47,9.74,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","RIPK3","ENSG00000129465; ENSG00000285379","Necroptosis; NOD-like receptor signaling pathway; Cytosolic DNA-sensing pathway; TNF signaling pathway; Salmonella infection","Regulation of necroptotic cell death; IKK complex recruitment mediated by RIP1; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; TRIF-mediated programmed cell death; TLR3-mediated TICAM1-dependent programmed cell death; TRP channels; Microbial modulation of RIPK1-mediated regulated necrosis","TNF-alpha signaling pathway; Nanoparticle triggered regulated necrosis; Cytosolic DNA-sensing pathway",158.3,169.6,173.1,165.4,163.6,189.6,0.9660624758966447,-0.049811602770723995,0.5702250893402934,0.2439536780782419,0.697418871818642,0.15650630500161122,5976]
["Q9Y575","Ankyrin repeat and SOCS box protein 3 [OS=Homo sapiens]",2,1,1,1,518,57.7,6.27,2.27,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol","","ASB3","ENSG00000115239","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",80.8,75.8,82.2,155.4,146.1,289.7,0.40392422192151556,-1.307843432881346,0.06468543855875312,1.1891934730457705,0.27567689237663356,0.5595996355405868,1715]
["Q9Y580","RNA-binding protein 7 [OS=Homo sapiens]",6,2,5,2,266,30.5,9.57,13.63,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","RBM7","ENSG00000076053","","","",461.7,455.3,466.2,584.2,643.4,620,0.7486468932669409,-0.417642677206755,9.0219451108507556E-4,3.0446998194603374,0.03381610093087598,1.4708764689388827,195]
["Q9Y587-1","AP-4 complex subunit sigma-1 [OS=Homo sapiens]",7,1,1,1,144,17,5.19,2.06,"transport;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","AP4S1","ENSCANG00000008358; ENSCATG00000035780; ENSG00000100478; ENSGGOG00000003198; ENSMMUG00000003123; ENSPANG00000017427; ENSPCOG00000016646; ENSPPAG00000041450; ENSPTRG00000006239; ENSRROG00000019504","Lysosome","Lysosome Vesicle Biogenesis","",32.3,32,28.7,30.7,30,18.3,1.1772151898734178,0.23537806293092856,0.3271646902316178,0.48523357439268966,0.5399066879437558,0.2676812927934754,4429]
["Q9Y592","Centrosomal protein of 83 kDa [OS=Homo sapiens]",2,2,2,2,693,82,6.28,4.99,"","","","","","","","",51.1,56.5,41.4,76.9,55.6,32.7,0.9019370460048426,-0.1489013560699215,0.7097008413664021,0.14892467990487512,0.7983997921420707,0.09777958478627082,6497]
["Q9Y597","BTB/POZ domain-containing protein KCTD3 [OS=Homo sapiens]",1,1,1,1,815,88.9,7.03,3.19,"cell organization and biogenesis","plasma membrane;other membranes","","KCTD3","ENSG00000136636","","CDC42 GTPase cycle","",127.2,126,115,203.7,200.9,316.9,0.5103257103257103,-0.9705097680286541,0.0374233558382637,1.4268572709062135,0.21187243053591742,0.6739255512886609,1291]
["Q9Y5A7","NEDD8 ultimate buster 1 [OS=Homo sapiens]",25,15,24,15,615,70.5,5.96,68.07,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus","","NUB1","ENSG00000013374","","","",3147.9,3114.8,3173.3,3527.5,3518,3302.6,0.9118582155178245,-0.13311857715449804,0.01567779917753054,1.8047149028848795,0.14359528093805854,0.842859832351636,798]
["Q9Y5A9-1","YTH domain-containing family protein 2 [OS=Homo sapiens]",16,9,24,6,579,62.3,8.79,62.04,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity","YTHDF2","ENSCSAG00000001018; ENSG00000198492; ENSMFAG00000026128; ENSMMUG00000011391; ENSMNEG00000041161; ENSNLEG00000009856; ENSPTRG00000000439; ENSRBIG00000043898; ENSRROG00000038863","","","",1106,1132.1,1089.3,1897.1,1811.7,1087.1,0.6938009549823808,-0.5274062684639943,0.129820296386303,0.8866574036874942,0.3748939337366608,0.42609158696177557,2531]
["Q9Y5B0","RNA polymerase II subunit A C-terminal domain phosphatase [OS=Homo sapiens]",12,10,17,10,961,104.3,5.27,44.42,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","CTDP1","ENSG00000060069","","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat","",1251,1251.9,1276.3,1329.1,1355.8,2080.4,0.7930665435544457,-0.33448617217590937,0.2528327972797554,0.5971665903827709,0.4934459052917842,0.30676045053428325,3745]
["Q9Y5B6","PAX3- and PAX7-binding protein 1 [OS=Homo sapiens]",14,11,23,11,917,104.7,5.68,71.3,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus","nucleic acid binding activity","PAXBP1","ENSG00000159086; ENSG00000263141","","","",2627,2648,2638.1,2689.1,2771.9,1931.6,1.0704082460839217,0.09816113519753913,0.5518675239677283,0.25816516233371994,0.6841247850542955,0.16486467530074203,5896]
["Q9Y5B8","Nucleoside diphosphate kinase 7 [OS=Homo sapiens]",11,4,5,4,376,42.5,6.47,11.96,"other metabolic processes","cytosol;cytoskeleton","kinase activity;other molecular function","NME7","ENSG00000143156","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors","Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes","Pyrimidine metabolism; Ciliopathies",393,417.5,415.3,407.5,395.5,324.7,1.0869912210694332,0.12034028869021049,0.2923983917923677,0.5340250203517325,0.5230396097920743,0.2814654207641883,4086]
["Q9Y5B9","FACT complex subunit SPT16 [OS=Homo sapiens]",41,44,216,44,1047,119.8,5.66,598.2,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus","other molecular function","SUPT16H","ENSG00000092201","","Regulation of TP53 Activity through Phosphorylation; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes","",30526,29929.3,30594.9,26839.8,27284.2,20747.8,1.216081355062921,0.2822397473832523,0.06366027308635555,1.196131502698319,0.27226034873503374,0.5650156035350828,1709]
["Q9Y5J1","U3 small nucleolar RNA-associated protein 18 homolog [OS=Homo sapiens]",23,8,18,8,556,62,8.76,49.37,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","","UTP18","ENSG00000011260","Ribosome biogenesis in eukaryotes","rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol","",831,822.9,902.5,1495.9,1639.9,1342.2,0.5708798570790531,-0.808740935698134,0.002025538067841663,2.6934595902990974,0.050875112501218955,1.2934946174010316,291]
["Q9Y5J6","Mitochondrial import inner membrane translocase subunit Tim10 B [OS=Homo sapiens]",24,1,1,1,103,11.6,7.43,2.04,"cell adhesion;cell organization and biogenesis;transport","other membranes;mitochondrion","transporter activity;other molecular function","TIMM10B","ENSG00000132286","","Mitochondrial protein import","",48.2,56.3,63.9,47.6,58.8,23,1.3013910355486862,0.3800545210738885,0.32162508015485364,0.49265009254745384,0.5379308262818823,0.26927356763390264,4370]
["Q9Y5J9","mitochondrial import inner membrane translocase subunit Tim8 B [OS=Homo sapiens]",13,1,2,1,83,9.3,5.12,3.6,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","TIMM8B","ENSG00000150779","","Mitochondrial protein import","",165.1,171.7,179.5,156.4,221.5,417.9,0.6487811007790902,-0.6241963009323778,0.3020624187321938,0.5199033043609576,0.5274185901848075,0.2778445664796523,4186]
["Q9Y5K5-1","Ubiquitin carboxyl-terminal hydrolase isozyme L5 [OS=Homo sapiens]",61,15,80,1,329,37.6,5.33,271.77,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","UCHL5","ENSCANG00000036448; ENSCATG00000035323; ENSG00000116750; ENSGGOG00000004347; ENSMFAG00000038349; ENSMLEG00000030039; ENSMNEG00000039813; ENSPPAG00000029294; ENSPTRG00000001793","","UCH proteinases; Downregulation of TGF-beta receptor signaling","TGF-beta signaling pathway",189.2,197.7,175.3,204.5,189.6,173.9,0.9897887323943662,-0.014807476011701456,0.8688472317937902,0.061056578236514454,0.910321734114222,0.04080508827705228,6976]
["Q9Y5K5-3","Isoform 3 of Ubiquitin carboxyl-terminal hydrolase isozyme L5 [OS=Homo sapiens]",61,15,82,1,328,37.5,5.4,278.15,"","","","UCHL5","","","","",8795.3,8761.2,8810.3,8897.7,8331.1,9127.4,1.000402182408693,5.8010991936976542E-4,0.9888226639101658,4.881588070061749E-3,0.9928980423848608,0.003095345566083031,7279]
["Q9Y5K6","CD2-associated protein [OS=Homo sapiens]",41,23,57,23,639,71.4,6.4,150.5,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","CD2AP","ENSG00000198087","Bacterial invasion of epithelial cells","Nephrin family interactions","Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome; Genes controlling nephrogenesis",7183.4,7200.1,7278,7636.1,8096.1,4549.7,1.0680212406135519,0.09494033936920869,0.7008650442072029,0.15436560000575023,0.7915053473594632,0.10154614672599313,6472]
["Q9Y5K8","V-type proton ATPase subunit D [OS=Homo sapiens]",39,11,36,11,247,28.2,9.36,101.86,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol","transporter activity","ATP6V1D","ENSG00000100554","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis","Neutrophil degranulation; Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Proximal tubule transport",3953.4,4001.6,3862.6,3850.9,3964.1,3413.4,1.0524740835737951,0.07378470838914931,0.31914949772212287,0.4960058347268348,0.5372325377362956,0.26983769196126317,4342]
["Q9Y5L0-2","transportin-3 [OS=Homo sapiens]",31,23,71,23,923,104.1,5.57,225.81,"transport","other membranes;nucleus;other cell component","other molecular function","TNPO3","ENSCANG00000033070; ENSCATG00000030018; ENSG00000064419; ENSGGOG00000008339; ENSMLEG00000037881; ENSMMUG00000004311; ENSMNEG00000045277; ENSPPAG00000034975; ENSPPYG00000017990; ENSPTRG00000019676","Nucleocytoplasmic transport","","",7200.6,6989.1,7191.5,7307.7,7200.5,6476.4,1.018899573973295,0.027011861836805713,0.6500890250935202,0.1870271657272577,0.7551653980306007,0.12195791779453392,6292]
["Q9Y5M8","signal recognition particle receptor subunit beta [OS=Homo sapiens]",50,11,82,11,271,29.7,9.04,282.32,"transport","other membranes;cytoskeleton;ER/Golgi;other cell component","other molecular function","SRPRB","ENSG00000144867","Protein export","XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane","",8662.3,9411.7,9133.5,8627.2,9191.7,9045.2,1.0127828589083572,0.018324892839815633,0.7000935072134628,0.15484395005044074,0.7911229814816326,0.10175599940083126,6468]
["Q9Y5N5","HemK methyltransferase family member 2 [OS=Homo sapiens]",24,5,9,5,214,22.9,5.11,21.42,"protein metabolism;DNA metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","N6AMT1","ENSG00000156239","","Eukaryotic Translation Termination; Methylation","",757.6,769.5,754,792.9,870.4,1349,0.7572618929057531,-0.40113576395794226,0.2337956155392688,0.6311636375922975,0.4759922434474974,0.32240012428664366,3590]
["Q9Y5N6","Origin recognition complex subunit 6 [OS=Homo sapiens]",7,1,1,1,252,28.1,8.66,2.55,"DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","ORC6","ENSG00000091651","Cell cycle","Assembly of the ORC complex at the origin of replication; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation","Cell cycle; G1 to S cell cycle control; DNA replication",62.3,69.9,69.1,95.5,93.2,97.6,0.7031086273140063,-0.5081804980780134,4.834518758623865E-4,3.315646750304044,0.024369308694332296,1.613156790655046,145]
["Q9Y5P4-1","Collagen type IV alpha-3-binding protein [OS=Homo sapiens]",24,14,34,14,624,70.8,5.48,79.24,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus","transporter activity;kinase activity;other molecular function","CERT1","ENSG00000113163; ENSPTRG00000016996","","","Sphingolipid pathway",3237.3,3179.3,3242.8,3195.8,3106.1,2711.5,1.07167106752169,0.09986216132228248,0.2248059690952827,0.6481921614716301,0.46892318154035995,0.3288982970837002,3504]
["Q9Y5P6","Mannose-1-phosphate guanyltransferase beta [OS=Homo sapiens]",45,11,38,11,360,39.8,6.61,132.58,"other metabolic processes","other cell component","other molecular function","GMPPB","ENSG00000173540","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars","Synthesis of GDP-mannose","",4201.7,3955.9,4009.1,4114.9,3863.4,3937.3,1.021073214945114,0.030086316804564264,0.47223155336261563,0.3258449977879067,0.62766692553689,0.20227075558581284,5499]
["Q9Y5Q8-1","general transcription factor 3C polypeptide 5 [OS=Homo sapiens]",23,10,18,10,519,59.5,6.9,39.12,"RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","nucleic acid binding activity","GTF3C5","ENSG00000148308","","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter","",1267.9,1226,1262.6,1287.4,1269,1408.4,0.9474626715092817,-0.07785899032585152,0.20302464199423217,0.6924512466551389,0.45007798251011316,0.3467122319143189,3297]
["Q9Y5Q9","General transcription factor 3C polypeptide 3 [OS=Homo sapiens]",23,14,28,14,886,101.2,5.07,89.01,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","nucleic acid binding activity","GTF3C3","ENSG00000119041","","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter","",1510.1,1506.9,1535.1,1570.2,1521.3,1454.1,1.0014299542414644,2.0615143083201476E-3,0.9533615114296327,0.02074238514563943,0.9688708686094529,0.013734101986838798,7192]
["Q9Y5R8","trafficking protein particle complex subunit 1 [OS=Homo sapiens]",4,1,1,1,145,16.8,9.16,1.79,"transport","non-structural extracellular;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","TRAPPC1","ENSG00000170043","","Neutrophil degranulation; COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs","",64.7,84.1,58.7,68.9,89.6,53.9,0.9769303201506593,-0.03367242968250395,0.9051991539897473,0.043255860614078906,0.9367266907137283,0.028387104981273295,7063]
["Q9Y5S1","Transient receptor potential cation channel subfamily V member 2 [OS=Homo sapiens]",17,7,12,7,764,85.9,5.83,30.85,"cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","transporter activity","TRPV2","ENSG00000187688","NOD-like receptor signaling pathway; Inflammatory mediator regulation of TRP channels","TRP channels","",928.8,929.6,953.5,936.5,977.1,2221.9,0.6799419659049692,-0.5565164795156382,0.35474895052644434,0.45007888066611434,0.5554541729643919,0.25535176615547395,4668]
["Q9Y5S2","Serine/threonine-protein kinase MRCK beta [OS=Homo sapiens]",3,4,5,4,1711,194.2,6.37,8.61,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","kinase activity;other molecular function","CDC42BPB","ENSG00000198752","","CDC42 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle","VEGFA-VEGFR2 signaling pathway",1083.3,943.5,1110.2,769.1,636.6,212.7,1.9383341571922887,0.9548173041726824,0.04487381889788457,1.34800696911851,0.2312995361950905,0.6358252380815848,1418]
["Q9Y5S9","RNA-binding protein 8A [OS=Homo sapiens]",47,7,39,1,174,19.9,5.72,112.15,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","RBM8A","ENSG00000265241","Nucleocytoplasmic transport; mRNA surveillance pathway; Spliceosome","Regulation of expression of SLITs and ROBOs; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); RNA Polymerase II Transcription Termination; mRNA 3'-end processing; Transport of Mature mRNA derived from an Intron-Containing Transcript","",1159,1059.5,1671.9,1846.1,1465,3052.4,0.6113616720358294,-0.7099019863934517,0.1844820641056784,0.7340458508522206,0.43245009831571635,0.3640639998210705,3118]
["Q9Y5S9-2","Isoform 2 of RNA-binding protein 8A [OS=Homo sapiens]",47,7,32,1,173,19.7,5.92,94.61,"","","","RBM8A","","","","",2150.9,2184.7,3263.1,3466.6,2847,2293.7,0.8828203966400614,-0.17980813292781592,0.5367433906728782,0.27023329465504986,0.673486256210827,0.17167126246913342,5825]
["Q9Y5T5-2","Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 16 [OS=Homo sapiens]",23,13,22,13,822,93.4,6.93,70.14,"","","","USP16","","","","",1584.5,1580.9,1631.5,1776.4,1733.1,2003,0.8701859410430838,-0.2006043863877631,0.04892741781648202,1.3104477038731035,0.24277698358497427,0.6147924888317614,1473]
["Q9Y5U2-1","Protein TSSC4 [OS=Homo sapiens]",13,4,9,4,329,34.3,5.19,23.79,"","","","TSSC4","ENSG00000184281","","","",697,693.3,752.9,775.7,803,1294,0.7460577157378077,-0.42264085182259115,0.22471700372898237,0.6483640644465835,0.468871418856732,0.32894623988030286,3503]
["Q9Y5U8","Mitochondrial pyruvate carrier 1 [OS=Homo sapiens]",27,2,4,2,109,12.3,9.61,11.35,"transport","other membranes;mitochondrion","transporter activity","MPC1","ENSG00000060762","Diabetic cardiomyopathy","Pyruvate metabolism","Glycolysis and gluconeogenesis",414.8,407.3,462.2,385.6,313,619.3,0.9745048941497837,-0.037258663895841995,0.9108946951562034,0.04053182714994155,0.9414210021064325,0.026216117270985224,7072]
["Q9Y5U9","immediate early response 3-interacting protein 1 [OS=Homo sapiens]",24,1,9,1,82,9,8.22,48,"transport;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","","IER3IP1","ENSG00000134049","","","",925.1,1003,1044.9,762.7,929.2,355.5,{"$f":"AVERAGE(S7234:U7234)/AVERAGE(V7234:X7234)","v":1.4520855719449057},{"$f":"LOG(Y7234,2)","v":0.5381264743962543},{"$f":"TTEST(S7234:U7234,V7234:X7234,2,2)","v":0.15084291411291562},{"$f":"-LOG10(AA7234)","v":0.8214750861117237},{"$f":"AA7234*7309/AE7234","v":0.4031118315361244},{"$f":"-LOG10(AC7234)","v":0.3945744548972003},2735]
["Q9Y5W8","Sorting nexin-13 [OS=Homo sapiens]",4,3,3,3,968,112.1,6.58,8.65,"transport;other biological processes","other membranes;other cytoplasmic organelle","other molecular function","SNX13","ENSG00000071189","","","",126.3,149.9,145.1,170.2,173.9,246.2,0.7137048958156869,-0.48660042588531244,0.09407975730023514,1.0265038116261913,0.33027326902373616,0.4811265749167357,2082]
["Q9Y5W9","Sorting nexin-11 [OS=Homo sapiens]",5,1,1,1,270,30.4,7.05,3.13,"cell organization and biogenesis;transport","other membranes;other cytoplasmic organelle","other molecular function","SNX11","ENSG00000002919","","","",56.5,68.7,63.4,62.3,59.7,130.6,0.7466349960411718,-0.4215249631124558,0.4149534613743895,0.38200060835213034,0.5857270855900758,0.23230469256701064,5178]
["Q9Y5X2","Sorting nexin-8 [OS=Homo sapiens]",15,6,8,6,465,52.5,7.39,23.67,"transport","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","SNX8","ENSG00000106266","","","",636.2,611.2,656.4,600.9,604.8,1394.9,0.7320618318849497,-0.44996258738015804,0.42920088787599986,0.3673393882921804,0.5954877163032808,0.2251271926979536,5268]
["Q9Y5X3","sorting nexin-5 [OS=Homo sapiens]",45,16,60,15,404,46.8,6.76,184.77,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","SNX5","ENSG00000089006","Endocytosis","Golgi Associated Vesicle Biogenesis","",8335.9,8064,8036.7,8027.7,7461.4,3522,1.285385906128525,0.36220155885487043,0.2718386781124182,0.5656887503418568,0.5076312974766645,0.2944516097798662,3914]
["Q9Y5Y0","Feline leukemia virus subgroup C receptor-related protein 1 [OS=Homo sapiens]",2,1,1,1,555,59.8,5.97,3.04,"other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion","transporter activity;other molecular function","FLVCR1","ENSG00000162769","","","",165.3,154.1,160.8,199.4,222.3,293.4,0.6715144735002098,-0.5745095997440305,0.051442429448991904,1.2886785293650052,0.24785281268469467,0.6058061482677627,1517]
["Q9Y5Y2","Cytosolic Fe-S cluster assembly factor NUBP2 [OS=Homo sapiens]",42,8,17,8,271,28.8,5.83,54.52,"cell organization and biogenesis;other metabolic processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","NUBP2","ENSG00000095906","","Cytosolic iron-sulfur cluster assembly","",1953,1968.2,1984.8,1820.8,1755.8,2313.3,1.0027334929285727,3.9382165975916485E-3,0.9771665552776083,0.01003140570489048,0.9848469873861059,6.6312392443885265E-3,7252]
["Q9Y5Y5","Peroxisomal membrane protein PEX16 [OS=Homo sapiens]",15,3,8,3,336,38.6,9.85,31.89,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","other molecular function","PEX16","ENSG00000121680","Peroxisome","Class I peroxisomal membrane protein import","",678.1,577.1,600.6,905.4,593.5,1253.7,0.6741989391847707,-0.5687537375653499,0.19653129532301092,0.7065682834366436,0.44334791281354535,0.3532553317592827,3240]
["Q9Y5Y6","suppressor of tumorigenicity 14 protein [OS=Homo sapiens]",20,16,31,16,855,94.7,6.55,89.97,"protein metabolism;developmental processes","non-structural extracellular;plasma membrane;other membranes","other molecular function","ST14","ENSG00000149418","MicroRNAs in cancer","Formation of the cornified envelope","",2883.5,2801.8,2947.4,3261.2,3742.2,4199.6,0.770570382933143,-0.3760013581717683,0.03536051948277244,1.4514813633749064,0.20842744911256755,0.6810450866531685,1240]
["Q9Y5Z7","host cell factor 2 [OS=Homo sapiens]",11,7,15,6,792,86.7,8.48,42.05,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","HCFC2","ENSG00000111727","Herpes simplex virus 1 infection","","",886.3,907.7,928.1,1041.4,1061.4,1913.2,0.6778137450199203,-0.5610392021330046,0.208057256627592,0.6818171322701663,0.4550240839889497,0.34196561594356584,3342]
["Q9Y5Z9-1","UbiA prenyltransferase domain-containing protein 1 [OS=Homo sapiens]",8,2,3,2,338,36.8,8.15,6.32,"other metabolic processes;other biological processes","other membranes;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","UBIAD1","ENSG00000120942; ENSGGOG00000001270","","Metabolism of vitamin K","7q11.23 copy number variation syndrome",103.8,107.9,97.3,118.8,131.8,200.7,0.6846886771548859,-0.5464799404207504,0.13751674905216743,0.8616444030850606,0.38583874043082217,0.4135941688366309,2605]
["Q9Y606","tRNA pseudouridine synthase A [OS=Homo sapiens]",36,15,26,15,427,47.4,8.41,75.22,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","PUS1","ENSG00000177192","","","",2355.3,2348.6,2365.2,2236.3,2178.9,2185.3,1.070994621619574,0.098951235100072,1.1438270607474846E-3,2.9416396330959658,0.03800105448637893,1.4202043520341991,220]
["Q9Y608","Leucine-rich repeat flightless-interacting protein 2 [OS=Homo sapiens]",5,3,11,2,721,82.1,6.95,36.04,"cell-cell signaling;signal transduction;other biological processes","","other molecular function","LRRFIP2","ENSG00000093167","","","VEGFA-VEGFR2 signaling pathway; Genotoxicity pathway",429.4,437.9,447.8,429.2,512.2,243.6,1.1097890295358648,0.15028544687224413,0.6147480583848806,0.21130283425913376,0.7264662180654958,0.1387845763403003,6185]
["Q9Y613","FH1/FH2 domain-containing protein 1 [OS=Homo sapiens]",38,33,92,33,1164,126.5,6.39,245.41,"cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","FHOD1","ENSG00000135723","Salmonella infection","","VEGFA-VEGFR2 signaling pathway",6131.3,6096.5,6108.7,6514.9,6516.3,8005.6,0.8716392226954669,-0.1981969774662843,0.14422840928306602,0.8409491863596068,0.39511448405169775,0.4032770497201451,2668]
["Q9Y617-1","phosphoserine aminotransferase [OS=Homo sapiens]",65,21,89,20,370,40.4,7.66,269.38,"other metabolic processes","cytosol;other cell component","other molecular function","PSAT1","ENSG00000135069; ENSGGOG00000015480; ENSPPAG00000036829; ENSPTRG00000021045","Glycine, serine and threonine metabolism; Cysteine and methionine metabolism; Vitamin B6 metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; Biosynthesis of cofactors","Serine biosynthesis","Trans-sulfuration and one-carbon metabolism; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Male infertility; Neuroinflammation and glutamatergic signaling",10973.5,11704.5,10989.4,15848.9,15281.6,15400.3,0.723550852338666,-0.4668336795973078,1.330402504218878E-4,3.876016946314532,0.01594083918579636,1.7974888194413259,61]
["Q9Y619","mitochondrial ornithine transporter 1 [OS=Homo sapiens]",5,2,2,2,301,32.7,9.13,2.12,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","SLC25A15","ENSG00000102743","","Urea cycle","",65.2,55.3,69,55,55.8,200.5,0.6087375522004497,-0.7161077284107257,0.4499675107312167,0.3468188427125107,0.6105091026423729,0.21430785637449268,5387]
["Q9Y624","Junctional adhesion molecule A [OS=Homo sapiens]",51,12,52,12,299,32.6,7.9,148.06,"cell adhesion;cell organization and biogenesis;stress response;transport;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","F11R","ENSG00000158769","Cell adhesion molecules; Tight junction; Leukocyte transendothelial migration; Epithelial cell signaling in Helicobacter pylori infection","Integrin cell surface interactions; Cell surface interactions at the vascular wall; Tight junction interactions; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)","1q21.1 copy number variation syndrome",6852.1,7254.1,7169.5,5188.2,5535.4,5637.2,1.300407070558897,0.37896330536770245,8.5902383209222736E-4,3.0659947872717006,0.03339683611043665,1.4762946746514074,188]
["Q9Y639-1","Isoform 1 of Neuroplastin [OS=Homo sapiens]",11,3,5,3,282,31.3,6.87,17.58,"","","","NPTN","","","","",913.9,851.8,902.4,973.3,1006.2,1224.5,0.8327403245942572,-0.2640614082104613,0.09237946167902009,1.034424572837602,0.3272910738787968,0.4850658389267807,2063]
["Q9Y657","Spindlin-1 [OS=Homo sapiens]",37,7,7,5,262,29.6,6.96,20.32,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;signal transduction;other biological processes","other membranes;cytosol;nucleus","other molecular function","SPIN1","ENSG00000106723","","","",365.8,365.3,383.2,406.6,441.5,824.5,0.6662082984574914,-0.5859547701922619,0.23719667958991458,0.6248913947591701,0.4793117310264544,0.3193819416368169,3617]
["Q9Y666","Solute carrier family 12 member 7 [OS=Homo sapiens]",8,8,13,7,1083,119,6.71,26.59,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;other cell component","transporter activity;other molecular function","SLC12A7","ENSG00000113504","Collecting duct acid secretion","Cation-coupled Chloride cotransporters","",537.8,531.1,551.9,513.3,557.1,880.5,0.8307960428520171,-0.26743375036027484,0.3963877508051891,0.40187977456998375,0.5758692249324443,0.23967613001175897,5031]
["Q9Y672","Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase [OS=Homo sapiens]",10,5,17,5,507,58.1,8.46,38.32,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","ALG6","ENSG00000088035","N-Glycan biosynthesis; Metabolic pathways","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG6 causes CDG-1c","GPCRs, other",1855.5,1944.8,1933.3,1533.1,1630.4,1181.4,1.3196161016364014,0.4001182865387187,0.029248323810586355,1.5338990178098986,0.19416530311678082,0.7118283748976774,1101]
["Q9Y673","dolichyl-phosphate beta-glucosyltransferase [OS=Homo sapiens]",37,13,32,13,324,36.9,9.28,77.45,"protein metabolism;other metabolic processes;developmental processes","other membranes;ER/Golgi","other molecular function","ALG5","ENSG00000120697","N-Glycan biosynthesis; Metabolic pathways","Synthesis of dolichyl-phosphate-glucose","",3031.1,3155.9,3191.3,2769.5,2689.6,1998.1,1.2576167998712653,0.33069239507642467,0.06232278716183108,1.2053531326471651,0.2698561915674309,0.5688676130528285,1688]
["Q9Y676","28S ribosomal protein S18b, mitochondrial [OS=Homo sapiens]",17,3,6,3,258,29.4,9.38,16.02,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus;other cell component","other molecular function","MRPS18B","ENSG00000203624; ENSG00000204568; ENSG00000223775; ENSG00000226111; ENSG00000227420; ENSG00000229861; ENSG00000233813","Viral carcinogenesis","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",199.5,192.3,215.7,191.5,178.6,205.2,1.055970797844603,0.07856993849626709,0.35776913598166454,0.44639712785754165,0.5567244230125583,0.2543597261568175,4697]
["Q9Y678","Coatomer subunit gamma-1 [OS=Homo sapiens]",67,46,229,42,874,97.7,5.47,675.39,"transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","COPG1","ENSG00000181789","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport","VEGFA-VEGFR2 signaling pathway",22401.7,22022.1,22373.2,22028.2,21004.3,20110,1.0578770241913134,0.08117192716736368,0.09833729067988362,1.007281761258234,0.3338352334320805,0.47646782919774827,2153]
["Q9Y679-1","Ancient ubiquitous protein 1 [OS=Homo sapiens]",13,6,16,6,476,53,8.09,46.26,"","","","","","","","",1569,1598.7,1597.5,1504.1,1496.8,2531.5,0.8613260067963271,-0.21536870236527844,0.49832247533479185,0.3024895248422736,0.6436188323417553,0.1913712568936287,5659]
["Q9Y689-1","ADP-ribosylation factor-like protein 5A [OS=Homo sapiens]",4,1,1,1,179,20.7,6.79,2.51,"transport;other biological processes","ER/Golgi","other molecular function","ARL5A; LOC111161526","ENSAMEG00000008735; ENSANAG00000027698; ENSCANG00000029546; ENSCATG00000029667; ENSCCAG00000023321; ENSCJAG00000040846; ENSECAG00000023672; ENSFCAG00000014742; ENSG00000162980; ENSGGOG00000002066; ENSLCNG00005010847; ENSMMUG00000010521; ENSMNEG00000035230; ENSMPUG00000000396; ENSNVIG00000004853; ENSOCUG00000035346; ENSOGAG00000011424; ENSPANG00000009772; ENSPPAG00000033494; ENSPTRG00000012538; ENSRBIG00000031831; ENSRFEG00010001991; ENSRROG00000040290; ENSSBOG00000034323; ENSSSCG00000031541; ENSSSCG00070004184; ENSSSUG00005001466","","","",28.6,40.9,42,40.5,34.5,84.8,0.6977471839799748,-0.5192236981203101,0.382682929542332,0.4171609100538305,0.5686175100680839,0.24517977072918887,4919]
["Q9Y692-1","Glucocorticoid modulatory element-binding protein 1 [OS=Homo sapiens]",8,4,8,4,573,62.6,4.83,26.33,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","GMEB1","ENSG00000162419; ENSGGOG00000009221; ENSPPAG00000038756","","","",264,309,297.1,328.5,354.8,419.1,0.78927793904209,-0.3413946695942023,0.0617540105983752,1.209334832008661,0.26946869460508915,0.569491681497552,1675]
["Q9Y696","Chloride intracellular channel protein 4 [OS=Homo sapiens]",74,15,147,13,253,28.8,5.59,511.58,"transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","transporter activity","CLIC4","ENSG00000169504","","","",14009.5,14616.4,13722,13157.6,13710.3,10461.1,1.1344504272817382,0.1819935681311274,0.182233274008331,0.7393723222101722,0.43035315015408443,0.3661750136823361,3095]
["Q9Y697","Cysteine desulfurase, mitochondrial [OS=Homo sapiens]",48,15,40,15,457,50.2,8.31,118.05,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytosol;mitochondrion;nucleus","other molecular function","NFS1","ENSG00000244005","Thiamine metabolism; Metabolic pathways; Biosynthesis of cofactors; Sulfur relay system","","",3001.5,3051.9,3153.9,2905,2766.2,3445.4,1.009948884452537,0.014282277122638812,0.8934793963373381,0.04891545788712432,0.9285427140380498,0.03219811341655757,7033]
["Q9Y6A4","Cilia- and flagella-associated protein 20 [OS=Homo sapiens]",38,7,19,7,193,22.8,9.76,47.39,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","","CFAP20","ENSG00000070761","","","",2282,2250.5,2246.7,2314.3,1875.6,1614.5,1.1679415615739783,0.2239680901968714,0.1872415619237489,0.7275977447501283,0.4358434955734652,0.36066943093937026,3140]
["Q9Y6A5","Transforming acidic coiled-coil-containing protein 3 [OS=Homo sapiens]",32,22,51,22,838,90.3,5.05,162.76,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","","TACC3","ENSG00000013810","","Negative regulation of NOTCH4 signaling; NOTCH3 Activation and Transmission of Signal to the Nucleus","",4780.4,4746.7,4780.9,4256.7,4354.1,6058.6,0.9753636822228584,-0.03598784042668603,0.8469526454335506,0.07214087113543995,0.8974161909935955,0.0470060992828389,6898]
["Q9Y6A9","Signal peptidase complex subunit 1 [OS=Homo sapiens]",17,2,7,2,102,11.8,9.31,25.02,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","translation activity;other molecular function","SPCS1","ENSG00000114902","Protein export","","",977.1,1116.4,1059.3,926.9,1087.6,853.2,1.0994176517766852,0.13673954796498008,0.3013451043220923,0.5209358597234341,0.5266693848613516,0.27846192632111433,4182]
["Q9Y6B6","GTP-binding protein SAR1b [OS=Homo sapiens]",47,8,65,4,198,22.4,6.11,172.63,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","SAR1B","ENSG00000152700","Protein processing in endoplasmic reticulum; Legionellosis","MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Chylomicron assembly","Sterol regulatory element-binding proteins (SREBP) signaling",2021.1,2158.7,2135.9,1919.2,1980,1847.4,1.0990324713743778,0.1362340119456811,0.02961173260585547,1.528536180954221,0.19568910815207743,0.7084333460389275,1106]
["Q9Y6B7","AP-4 complex subunit beta-1 [OS=Homo sapiens]",5,5,8,5,739,83.2,5.86,15.67,"transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","other molecular function","AP4B1","ENSG00000134262","Lysosome","Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis","",545.5,575.3,535,516,580.7,489.9,1.0436152779528551,0.061589969683373595,0.47886955426778427,0.3197827738027033,0.632235833118359,0.19912089336743174,5536]
["Q9Y6C2","EMILIN-1 [OS=Homo sapiens]",4,3,3,3,1016,106.6,5.15,9.3,"","","","","","","","",286.3,274.5,280.8,477.6,481,684.7,0.5121402056836851,-0.9653892722512901,0.01757285197821638,1.7551577491542465,0.15308697867554652,0.8150617480989738,839]
["Q9Y6C9","Mitochondrial carrier homolog 2 [OS=Homo sapiens]",45,12,36,12,303,33.3,7.97,143.4,"other biological processes","other membranes;mitochondrion","","MTCH2","ENSG00000109919; ENSG00000285121","","","",4924.9,4777.6,4678.3,5305.7,4488.1,6752.8,0.8691090616803452,-0.20239086736120082,0.3393347830577583,0.46937162129856946,0.5472634442562126,0.2618035606059561,4532]
["Q9Y6D0","selenoprotein K [OS=Homo sapiens]",10,1,2,1,94,10.6,10.86,4.11,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi","other molecular function","SELENOK","ENSG00000113811","","","Selenium micronutrient network",101.9,129.5,109.2,154.8,207.7,57.5,0.8109523809523811,-0.3023108928749423,0.5860694800954891,0.23205089416390656,0.7067450635238294,0.1507372162899437,6061]
["Q9Y6D5","Brefeldin A-inhibited guanine nucleotide-exchange protein 2 [OS=Homo sapiens]",29,43,115,33,1785,201.9,6.33,337.73,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","ARFGEF2","ENSG00000124198","Endocytosis","Association of TriC/CCT with target proteins during biosynthesis","",9683.2,9479.2,10290.4,9717.7,9331.1,9292.4,1.0392220512892891,0.055503948820079724,0.2547301360274553,0.5939196724835283,0.49450798518583555,0.3058266911362747,3765]
["Q9Y6D6","Brefeldin A-inhibited guanine nucleotide-exchange protein 1 [OS=Homo sapiens]",21,30,54,20,1849,208.6,5.85,148.05,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","ARFGEF1","ENSG00000066777","Endocytosis","","",2042.6,2100.3,2132.2,2356.2,2376,1933.4,0.9414156265002399,-0.08709629445495239,0.42507399100859977,0.371535467385285,0.5930264936594495,0.22692590394925818,5239]
["Q9Y6D9","mitotic spindle assembly checkpoint protein MAD1 [OS=Homo sapiens]",30,21,46,21,718,83,5.92,141.24,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","MAD1L1","ENSG00000002822","Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection; Viral carcinogenesis","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; Malignant pleural mesothelioma; CCL18 signaling pathway",5190.3,5052.7,4983.5,5338.1,5330,5061.8,0.9679972536379761,-0.046925140536762215,0.19934776787004585,0.7003886228415629,0.44666855774437925,0.3500146176618469,3262]
["Q9Y6E0","Serine/threonine-protein kinase 24 [OS=Homo sapiens]",44,16,82,9,443,49.3,5.69,238.94,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","STK24","ENSG00000102572","","Apoptotic cleavage of cellular proteins","",4003.2,3793.1,3860.6,4121.6,3869.7,5162.4,0.8862069227669781,-0.17428449814409633,0.2808050038228245,0.551595157534829,0.5149031040996047,0.28827449001532485,3986]
["Q9Y6E2","Basic leucine zipper and W2 domain-containing protein 2 [OS=Homo sapiens]",43,20,98,16,419,48.1,6.68,245.56,"developmental processes;other biological processes","other cell component","","BZW2","ENSG00000136261","","","",7937.9,7868.6,7860.4,7724.9,7336.2,6070.7,1.1199661174154592,0.16345508676850018,0.16627373126832556,0.779176357312891,0.4186340688391979,0.37816543126059177,2903]
["Q9Y6G1","Transmembrane protein 14A [OS=Homo sapiens]",6,1,1,1,99,10.7,10.55,0,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion;ER/Golgi","","TMEM14A","ENSG00000096092","","","",61.6,37,70.1,46.5,23.5,35.4,1.6005692599620491,0.6785851066503509,0.1519828809329298,0.8182053274174936,0.4036493011405465,0.3939957950969944,2752]
["Q9Y6G5","COMM domain-containing protein 10 [OS=Homo sapiens]",29,4,8,4,202,23,6.54,19.29,"","nucleus;other cell component","","COMMD10","ENSG00000145781","","Neddylation","",280.7,258.5,276.7,284.1,293,230.9,1.0097772277227726,0.014037047522575856,0.9042484243620458,0.04371223931664974,0.9362730887749247,0.02859745932836046,7059]
["Q9Y6G9","Cytoplasmic dynein 1 light intermediate chain 1 [OS=Homo sapiens]",54,23,68,23,523,56.5,6.42,245.49,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","DYNC1LI1","ENSG00000144635","Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection","Neutrophil degranulation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; MHC class II antigen presentation; COPI-mediated anterograde transport; HCMV Early Events; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy","Ciliary landscape; Intraflagellar transport proteins binding to dynein",9441.1,9545.6,9817.2,8953,9569,7860.4,1.0917846746315727,0.1266883512460551,0.19004412041809107,0.7211455620486603,0.43831886277558463,0.3582098393549879,3169]
["Q9Y6H1","Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 [OS=Homo sapiens]",15,2,2,2,151,15.5,9.22,5.96,"cell organization and biogenesis;stress response;other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","CHCHD2","ENSG00000106153","","Mitochondrial protein import","",164.8,168.4,184.1,306.1,312.3,373.5,0.5215243472124206,-0.9391934887718677,2.0881836436694367E-3,2.6802313103033217,0.05191338180809494,1.284720678831506,294]
["Q9Y6H3","Mitochondrial inner membrane protease ATP23 homolog [OS=Homo sapiens]",14,2,2,2,246,28.1,8.03,7.23,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component","kinase activity;other molecular function","ATP23","ENSG00000166896; ENSG00000262145","","","",46.6,48.5,42.4,55.8,46.9,68.5,0.8031542056074767,-0.3162510831017625,0.16007550948697322,0.7956751072328034,0.41211408905962915,0.3849825378746877,2839]
["Q9Y6I3","epsin-1 [OS=Homo sapiens]",20,10,24,9,576,60.3,4.83,78.69,"transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","EPN1","ENSG00000063245","Endocytosis","Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation","VEGFA-VEGFR2 signaling pathway; EGF/EGFR signaling pathway",2864.7,2765.9,2868.6,2795.7,2836.8,2571.1,1.0360329611390122,0.0510699027497037,0.3310480935792771,0.4801089087655488,0.5419105298927069,0.266072410106141,4465]
["Q9Y6I4-1","Ubiquitin carboxyl-terminal hydrolase 3 [OS=Homo sapiens]",10,4,6,4,520,58.9,8.18,22.19,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","USP3","ENSG00000140455","","Ub-specific processing proteases","",448.6,457.7,456,496.4,427.7,1107.7,0.6704892213800571,-0.5767139549821169,0.360182524422522,0.44347736239649976,0.5566872639044647,0.2543887145279531,4729]
["Q9Y6I9","Testis-expressed protein 264 [OS=Homo sapiens]",52,11,32,11,313,34.2,4.86,102.42,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","TEX264","ENSG00000164081","","Platelet degranulation","",2411.4,2636,2643.9,2572,3068.2,3293,0.8609792683472887,-0.21594959572360584,0.1412383771028067,0.8500472813337002,0.39132346408052093,0.4074641106600737,2638]
["Q9Y6J0","Calcineurin-binding protein cabin-1 [OS=Homo sapiens]",5,9,12,9,2220,246.2,6.02,36.69,"cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity","CABIN1","ENSG00000099991","","Formation of Senescence-Associated Heterochromatin Foci (SAHF)","",1203.5,1154.2,1142.3,1293.8,1297.2,1434.8,0.8693924188981073,-0.20192057951727058,0.02490194400511751,1.603766747774148,0.1796725653834194,0.7455182312504555,1013]
["Q9Y6J9","TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L [OS=Homo sapiens]",13,6,8,6,622,67.8,8.97,15.23,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","TAF6L","ENSG00000162227","Basal transcription factors","HATs acetylate histones","",624.1,601.7,551.5,761.6,817,1088.5,0.6663792133778262,-0.5855846960213079,0.045364098724838355,1.343287713084236,0.23186447383205844,0.6347657886653247,1430]
["Q9Y6K0","Choline/ethanolaminephosphotransferase 1 [OS=Homo sapiens]",1,1,1,1,416,46.5,8.21,1.82,"other metabolic processes","other membranes;ER/Golgi;nucleus","other molecular function","CEPT1","ENSG00000134255","Phosphonate and phosphinate metabolism; Glycerophospholipid metabolism; Ether lipid metabolism; Metabolic pathways","Synthesis of PC; Synthesis of PE","Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways",91.2,80.5,84.9,73.6,76.1,84,1.0979888746255886,0.13486343630685743,0.1586477290167136,0.7995661402831961,0.41075318858772925,0.3864190565461424,2823]
["Q9Y6K1","DNA (cytosine-5)-methyltransferase 3A [OS=Homo sapiens]",2,2,3,2,912,101.8,6.57,4.65,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DNMT3A","ENSG00000119772","Cysteine and methionine metabolism; Metabolic pathways; MicroRNAs in cancer","PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; RMTs methylate histone arginines; SUMOylation of DNA methylation proteins","One-carbon metabolism; Trans-sulfuration and one-carbon metabolism; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; One-carbon metabolism and related pathways; MTHFR deficiency",85.6,80.8,95.1,144.3,93.2,2564.1,0.09333952027412908,-3.4213681372992544,0.35766235804566515,0.44652676450095197,0.5571513586862247,0.25402680606047073,4692]
["Q9Y6K5","2'-5'-oligoadenylate synthase 3 [OS=Homo sapiens]",5,6,10,6,1087,121.1,8.4,24.05,"other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","OAS3","ENSG00000111331","NOD-like receptor signaling pathway; Hepatitis C; Measles; Influenza A; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease","Interferon gamma signaling; Interferon alpha/beta signaling; OAS antiviral response","Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction",788.8,694.5,762.6,778.8,717.1,1416.2,0.7712303835719926,-0.3747662054497068,0.3799565389325198,0.42026607701803054,0.5679145895823695,0.24571697425767783,4890]
["Q9Y6K9","NF-kappa-B essential modulator [OS=Homo sapiens]",11,4,4,4,419,48.2,5.71,12.21,"cell organization and biogenesis;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","IKBKG","ENSG00000269335","Antifolate resistance; MAPK signaling pathway; Ras signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; TNF signaling pathway; Adipocytokine signaling pathway; Alcoholic liver disease; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Chagas disease; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Chemical carcinogenesis; Pancreatic cancer; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Primary immunodeficiency; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; TNFR1-induced NFkappaB signaling pathway; activated TAK1 mediates p38 MAPK activation; ER-Phagosome pathway; IKK complex recruitment mediated by RIP1; TICAM1, RIP1-mediated IKK complex recruitment; Regulation of TNFR1 signaling; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Ovarian tumor domain proteases; RIP-mediated NFkB activation via ZBP1; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; SUMOylation of immune response proteins","Nucleotide-binding oligomerization domain (NOD) pathway; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; ATM signaling in development and disease ; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNAs involvement in the immune response in sepsis; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Canonical NF-kB pathway; Cytosolic DNA-sensing pathway; Small cell lung cancer; Hepatitis B infection; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Network map of SARS-CoV-2 signaling pathway; T-cell receptor (TCR) signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway",394.8,441.7,337,501.9,591,540.5,0.7184400636708705,-0.47706029095576713,0.018242365461975846,1.7389188479990694,0.15612816061075113,0.8065187568041013,854]
["Q9Y6M1","Insulin-like growth factor 2 mRNA-binding protein 2 [OS=Homo sapiens]",23,13,35,13,599,66.1,8.46,107.13,"transport;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","IGF2BP2","ENSG00000073792","","Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA","",4268.8,4080.3,4114.6,4302.3,3808.4,3281.5,1.094055581889363,0.1296860339981139,0.3001785952787998,0.5226202790605283,0.5257621262623408,0.27921070188826413,4173]
["Q9Y6M5","zinc transporter 1 [OS=Homo sapiens]",45,15,58,15,507,55.3,6.48,185.42,"stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","SLC30A1","ENSG00000170385","Mineral absorption","Zinc efflux and compartmentalization by the SLC30 family","Zinc homeostasis",5724.6,5915.3,5879.1,4652.4,4872.3,6217.9,1.112840318625894,0.15424659532699622,0.2958062052701815,0.5289927198376657,0.5243869886780879,0.2803480927550512,4123]
["Q9Y6M7-7","Isoform 7 of Sodium bicarbonate cotransporter 3 [OS=Homo sapiens]",7,8,12,8,1259,140.7,6.62,35,"","","","SLC4A7","","","","",956.8,1028.2,1037,1017.8,1068.7,1082.7,0.9535529471159916,-0.0686150468360574,0.20167663131850933,0.6953444214569633,0.448449801736229,0.3482861636546146,3287]
["Q9Y6M9","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [OS=Homo sapiens]",11,1,1,1,179,21.8,8.38,3.79,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity","NDUFB9","ENSG00000147684","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial immune response to SARS-CoV-2; Oxidative phosphorylation",26.2,23,23.9,23.1,29.9,33.1,0.849012775842044,-0.2361418314444068,0.23451712655292228,0.6298254356959007,0.4769297935379268,0.32154554658488266,3594]
["Q9Y6N1","Cytochrome c oxidase assembly protein COX11, mitochondrial [OS=Homo sapiens]",12,2,10,2,276,31.4,9.06,13.74,"other metabolic processes;other biological processes","other membranes;mitochondrion;other cell component","other molecular function","COX11","ENSG00000166260","Oxidative phosphorylation; Metabolic pathways; Thermogenesis","Cytoprotection by HMOX1; Respiratory electron transport; TP53 Regulates Metabolic Genes","Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis; Mitochondrial complex IV assembly",188.1,202.5,196.8,172.4,203.8,268.9,0.9105565028677727,-0.1351795511856268,0.5397930999161317,0.26777267125690407,0.6755732478231176,0.1703275564853306,5840]
["Q9Y6N5","Sulfide:quinone oxidoreductase, mitochondrial [OS=Homo sapiens]",71,29,161,29,450,49.9,9.11,531.19,"other metabolic processes","other membranes;mitochondrion","other molecular function","SQOR","ENSG00000137767","Sulfur metabolism; Metabolic pathways","Sulfide oxidation to sulfate","",19790.1,20085.5,20316.5,17622.6,17755.9,13034,1.2433173250710043,0.31419455454003725,0.06552987321769724,1.1835606722835645,0.2771746778635122,0.5572464485424662,1728]
["Q9Y6N7","Roundabout homolog 1 [OS=Homo sapiens]",4,7,11,6,1651,180.8,6.04,21.23,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","ROBO1","ENSG00000169855","Axon guidance","Regulation of expression of SLITs and ROBOs; Netrin-1 signaling; Regulation of cortical dendrite branching; Regulation of commissural axon pathfinding by SLIT and ROBO; Role of ABL in ROBO-SLIT signaling; Inactivation of CDC42 and RAC1; Activation of RAC1; SLIT2:ROBO1 increases RHOA activity","Development of ureteric collection system",593.5,653,621.1,598.1,611.8,959.3,0.8609625668449198,-0.21597758177301968,0.4472852202827921,0.34941545205241387,0.6086776531459556,0.2156126425439407,5371]
["Q9Y6P5-2","Isoform T1 of Sestrin-1 [OS=Homo sapiens]",25,13,29,13,551,63.8,6.3,95.15,"","","","SESN1","","","","",2788.6,2858.7,2679.5,3211.2,2917.4,3065.4,0.905677615836415,-0.1429304936256634,0.043962436218001145,1.356918248761785,0.22853587931534167,0.6410456075616172,1406]
["Q9Y6Q9-1","Nuclear receptor coactivator 3 [OS=Homo sapiens]",3,3,4,3,1424,155.2,7.47,12.25,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","NCOA3","ENSG00000124151","Endocrine resistance; Estrogen signaling pathway; Thyroid hormone signaling pathway; Pathways in cancer; Breast cancer","PPARA activates gene expression; Estrogen-dependent gene expression; Transcriptional regulation of white adipocyte differentiation; MAPK6/MAPK4 signaling; Activation of anterior HOX genes in hindbrain development during early embryogenesis","Androgen receptor signaling pathway; Integrated breast cancer pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Breast cancer pathway; EGF/EGFR signaling pathway",247.1,235.2,225,425.3,437.5,519.3,{"$f":"AVERAGE(S7298:U7298)/AVERAGE(V7298:X7298)","v":0.5117574705158816},{"$f":"LOG(Y7298,2)","v":-0.9664678373601227},{"$f":"TTEST(S7298:U7298,V7298:X7298,2,2)","v":0.00173446744359044},{"$f":"-LOG10(AA7298)","v":2.7608338475669307},{"$f":"AA7298*7309/AE7298","v":0.04609899107346373},{"$f":"-LOG10(AC7298)","v":1.3363085795132204},275]
["Q9Y6R4-1","Mitogen-activated protein kinase kinase kinase 4 [OS=Homo sapiens]",4,5,7,4,1608,181.6,6.32,20.22,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","other cell component","kinase activity;other molecular function","MAP3K4","ENSG00000085511","MAPK signaling pathway; GnRH signaling pathway","","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; EGF/EGFR signaling pathway; Insulin signaling; MAP3K1 role in promoting and blocking gonadal determination; Host-pathogen interaction of human coronaviruses - MAPK signaling; Malignant pleural mesothelioma; G13 signaling pathway; DNA damage response (only ATM dependent)",136.7,121.6,123.7,122.4,128,303.8,0.6892818477084084,-0.5368340725583062,0.3910644085247839,0.40775170817126677,0.5738385388290796,0.24121028801967717,4981]
["Q9Y6R9","Coiled-coil domain-containing protein 61 [OS=Homo sapiens]",8,5,8,5,512,57.3,10.27,17.7,"cell cycle OR cell proliferation;cell organization and biogenesis","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","CCDC61","ENSG00000104983","","","",386.4,394.5,375.1,539.6,528.9,625.7,0.6823279423916893,-0.5514627967704331,0.004509866192827678,2.3458363433944682,0.07665723721715696,1.1154468370900819,430]
["Q9Y6V0-1","Protein piccolo [OS=Homo sapiens]",0,1,6,1,5065,552.9,6.51,12.09,"","","","","","","","",524.7,506.6,523.6,503.2,483.7,692.5,0.9258663808503037,-0.11112409318821558,0.5683350139508392,0.245395587141592,0.6963890388879604,0.15714807326397964,5965]
["Q9Y6V7","Probable ATP-dependent RNA helicase ddx49 [OS=Homo sapiens]",10,3,4,3,483,54.2,9.06,15.77,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","DDX49","ENSG00000105671","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",294.1,332.9,336,690.1,672.8,426,0.538319637766225,-0.8934650394145047,0.03327950570604177,1.4778231328240032,0.20337784883399604,0.6916963505924224,1196]
["Q9Y6W3","Calpain-7 [OS=Homo sapiens]",18,12,25,12,813,92.6,7.65,63.85,"protein metabolism;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","CAPN7","ENSG00000131375","","Degradation of the extracellular matrix","Integrin-mediated cell adhesion",2891.7,2844.3,2845.7,3159.8,3240.7,2513.4,0.9627323618169378,-0.054793308184068065,0.6562546670427338,0.18292759503177886,0.7590703214773448,0.11971798851179395,6319]
["Q9Y6W5","Wiskott-Aldrich syndrome protein family member 2 [OS=Homo sapiens]",24,13,44,12,498,54.3,5.53,115.77,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","WASF2","ENSG00000158195","Adherens junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Yersinia infection; Choline metabolism in cancer","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RAC2 GTPase cycle; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway","Regulation of actin cytoskeleton",5690.1,5563.7,5549.8,5647.1,5771.9,5427.9,0.997429794205462,-0.003712796525928868,0.9019454100211355,0.044819747207545266,0.934682972046573,0.029335669168174087,7053]
["Q9Y6X3-1","MAU2 chromatid cohesion factor homolog [OS=Homo sapiens]",7,3,4,3,613,69,7.25,16.13,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MAU2","ENSANAG00000026794; ENSCANG00000033671; ENSCATG00000015302; ENSCCAG00000031923; ENSCSAG00000005122; ENSG00000129933; ENSGGOG00000002989; ENSMFAG00000041829; ENSMNEG00000034232; ENSPPAG00000032359; ENSPTRG00000010738; ENSRBIG00000036077; ENSRROG00000032649; ENSSBOG00000034577","","Cohesin Loading onto Chromatin","Cohesin complex - Cornelia de Lange syndrome",327.4,342.3,381.8,333.8,303.7,285.3,1.1394668400520158,0.18835894093615926,0.11702176627350688,0.9317333511317393,0.36028310433574634,0.44335610386633867,2374]
["Q9Y6X4-1","Soluble lamin-associated protein of 75 kDa [OS=Homo sapiens]",6,4,6,4,670,74.9,4.6,19.28,"","other membranes;nucleus","","FAM169A","ENSG00000198780","","RHOF GTPase cycle","",504.2,492.6,512.8,482.1,513.4,352,1.1202968460111316,0.163881055073215,0.33860975624943457,0.4703005328654413,0.5465765698823138,0.2623489891616834,4528]
["Q9Y6X5","Bis(5'-adenosyl)-triphosphatase ENPP4 [OS=Homo sapiens]",11,5,11,5,453,51.6,6.15,29.68,"other metabolic processes;stress response;other biological processes","plasma membrane;other membranes","other molecular function","ENPP4","ENSG00000001561","Purine metabolism; Metabolic pathways","Neutrophil degranulation","",848.4,938.9,943.4,854.5,909,930,1.0138110265453868,0.01978876035570803,0.7620946871601999,0.11799106598789465,0.836861488649925,0.0773464173865892,6656]
["Q9Y6X9-1","MORC family CW-type zinc finger protein 2 [OS=Homo sapiens]",12,12,19,12,1032,117.8,8.38,55.94,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","MORC2","ENSG00000133422","","Fatty acyl-CoA biosynthesis","",2670.7,2528.2,2641.9,2921,2816.5,2971.2,0.9003410382720727,-0.1514565145255027,0.010089572546343194,1.9961272326428499,0.1159507637440604,0.9357263864072908,636]
["Q9Y6Y0","influenza virus NS1A-binding protein [OS=Homo sapiens]",1,1,1,1,642,71.7,5.53,0,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","","IVNS1ABP","ENSG00000116679","","","",57.9,58.1,51.9,143.5,125.7,55.5,0.5170927009547275,-0.951505154349058,0.1243570118111634,0.9053297222151632,0.36843348168941764,0.4336409098209263,2467]
["Q9Y6Y8","SEC23-interacting protein [OS=Homo sapiens]",29,26,73,26,1000,111,5.54,187.51,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","SEC23IP","ENSG00000107651","","COPII-mediated vesicle transport","",7334.9,7379.5,7333.9,7629.8,7327.7,8771,0.9291906357334008,-0.10595347996692135,0.27177638452826514,0.5657882831246411,0.5076446702062586,0.29444016914134835,3913]

{"sheet":"Le-P","index":2,"n_rows":7310,"n_cols":31,"rows_kept":2250,"cut":true,"bounds":{"rows_first":1000,"rows_last":250,"rows_between":1000,"halvings":1}}
["Accession","Description","Coverage [%]","# Peptides","# PSMs","# Unique Peptides","# AAs","MW [kDa]","calc. pI","Score Sequest HT: Sequest HT","Biological Process","Cellular Component","Molecular Function","Gene Symbol","Ensembl Gene ID","KEGG Pathways","Reactome Pathways","WikiPathways","Abundances (Normalized): F7: 129C, Sample, Le-P","Abundances (Normalized): F7: 130C, Sample, Le-P","Abundances (Normalized): F7: 131C, Sample, Le-P","Abundances (Normalized): F7: 126, Sample, DMSO","Abundances (Normalized): F7: 127C, Sample, DMSO","Abundances (Normalized): F7: 128C, Sample, DMSO","Ratio","log2(Ratio)","P-Value","− log10(P-Value)","q-Value","− log10(q-Value)","Rank (P-Value)"]
["A0A096LP01","Small integral membrane protein 26 [OS=Homo sapiens]",17,1,1,1,95,10.9,6.7,3.05,"","other membranes","","SMIM26","ENSG00000232388","","","",49.4,52.7,54,251.3,281.5,85.3,{"$f":"AVERAGE(S2:U2)/AVERAGE(V2:X2)","v":0.25254813137032844},{"$f":"LOG(Y2,2)","v":-1.985369727728161},{"$f":"TTEST(V2:X2,S2:U2,2,2)","v":0.06506181158819652},{"$f":"-LOG10(AA2)","v":1.186673848342764},{"$f":"AA2*7309/AE2","v":0.2585844376825059},{"$f":"-LOG10(AC2)","v":0.5873976156968684},1839]
["A0A0B4J2F0","Protein PIGBOS1 [OS=Homo sapiens]",19,1,1,1,54,6.3,8.5,3.82,"stress response;other biological processes","other membranes;mitochondrion","","PIGBOS1","ENSG00000225973","","","",68.4,68.3,56.4,42.3,98.1,55.7,0.9847016828148903,-0.02224137124149867,0.9566347641033005,{"$f":"-LOG10(AA3)","v":0.019253840917639906},0.9721973708052035,{"$f":"-LOG10(AC3)","v":0.012245557758839277},7192]
["A0A1B0GVM6","Uncharacterized protein C11orf97 [OS=Homo sapiens]",6,1,1,1,126,13.9,9.35,2.08,"","cytoskeleton;other cell component","","C11orf97","ENSG00000257057","","","",184.5,178.5,190.1,184.6,165.2,271.8,0.889800514800515,-0.1684461616917845,0.5264914334436337,0.2786086908382783,0.6685416759971367,0.17487151421887293,5756]
["A0AV96","RNA-binding protein 47 [OS=Homo sapiens]",22,9,24,9,593,64.1,7.68,76.54,"RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus","nucleic acid binding activity","RBM47","ENSG00000163694","","","TYROBP causal network in microglia",1430.6,1472.7,1492.5,2427.4,2137.3,2465,0.6253182923880108,-0.6773373739737252,1.1240559533249796E-3,2.9492120698919897,0.04107862481426138,1.3863841036719982,200]
["A0AVK6","Transcription factor E2F8 [OS=Homo sapiens]",2,1,1,1,867,94.1,8.98,2.02,"cell cycle OR cell proliferation;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","E2F8","ENSG00000129173","","TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest","Genotoxicity pathway",43.6,57.9,72.5,55.7,63.9,429.8,0.31670913724062616,-1.6587696043397653,0.3687393422569097,0.4332805233280956,0.5620679567373833,0.250211172950805,4795]
["A0AVT1-1","Ubiquitin-like modifier-activating enzyme 6 [OS=Homo sapiens]",46,38,125,37,1052,117.9,6.14,376.11,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","UBA6; UBE1L2","ENSG00000033178","Ubiquitin mediated proteolysis","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation","",12152.3,12141.6,12565.9,11917.7,11594.7,13800.7,0.9878514516349484,-0.017633982330687626,0.8400829513168384,0.07567782879465496,0.8922066682904347,0.049534535195593324,6882]
["A0FGR8-2","Isoform 2 of Extended synaptotagmin-2 [OS=Homo sapiens]",31,20,56,20,893,98.8,8.68,171.95,"","","","ESYT2","","","","",4150.3,4323.4,4499.5,3942.7,3944,5552,0.965361232857345,-0.050859202937506245,0.790225910468255,0.10224873447625969,0.8591047418730441,0.0659538838470104,6723]
["A0JLT2","Mediator of RNA polymerase II transcription subunit 19 [OS=Homo sapiens]",5,1,1,1,244,26.3,9.82,3.01,"other biological processes","nucleus","other molecular function","MED19","ENSG00000156603","","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","",113.8,109.3,116.4,105.2,117.4,226.6,0.7557880676758681,-0.40394635326850714,0.3976710355270799,0.400476039813242,0.5785385347666057,0.23766770865840872,5024]
["A0JNW5-1","UHRF1-binding protein 1-like [OS=Homo sapiens]",9,10,15,10,1464,164.1,6.32,37.87,"","cytosol;other cytoplasmic organelle","other molecular function","UHRF1BP1L","ENSG00000111647","","RND2 GTPase cycle","",938.7,908.5,975.5,1131,1203.2,1931.1,0.6617822896396502,-0.5955714115641004,0.13381495504026802,0.8734953474910666,0.3707556885478844,0.4309121768174401,2638]
["A0MZ66","Shootin-1 [OS=Homo sapiens]",37,24,49,24,631,71.6,5.33,145.6,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SHTN1","ENSG00000187164","","Recycling pathway of L1","",5733.7,5937.9,5169.3,6728.1,6456.4,8164.3,0.7888452746758599,-0.3421857393227802,0.05994191578831372,1.222269380793159,0.2506381364398083,0.6009528472075704,1748]
["A0PJW6","Transmembrane protein 223 [OS=Homo sapiens]",4,1,1,1,202,22,11.02,3.28,"developmental processes","other membranes","","TMEM223","ENSG00000168569","","","",18.8,14.9,20.9,21.1,21,122.1,0.3325213154689403,-1.5884812708579523,0.3396739725842297,0.4689377295388688,0.5490219074785792,0.2604103256642368,4522]
["A0PK00","Transmembrane protein 120B [OS=Homo sapiens]",9,2,2,2,339,40.2,8.9,9.39,"cell organization and biogenesis;transport;other biological processes","other membranes;nucleus","","TMEM120B","ENSG00000188735","","","",262.4,294.5,261.7,219.3,255,285.2,1.0778143515470704,0.108108702053639,0.41929794954274585,0.3774772613847653,0.5934641195212876,0.226605533095175,5164]
["A1A4S6","Rho GTPase-activating protein 10 [OS=Homo sapiens]",23,14,19,14,786,89.3,7.18,61.26,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","enzyme regulator activity","ARHGAP10","ENSG00000071205","Bacterial invasion of epithelial cells","Regulation of PAK-2p34 activity by PS-GAP/RHG10; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle","Ectoderm differentiation; Ectoderm differentiation",1519.9,1495.7,1638.4,1464.4,1402.6,1580.4,1.046454108018168,0.06550904395257577,0.3701267122937778,0.4316495704489289,0.5620727488375695,0.2502074702423144,4813]
["A1L0T0","Acetolactate synthase-like protein [OS=Homo sapiens]",30,13,32,13,632,67.8,8.15,108.67,"other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","ILVBL","ENSG00000105135","","","",2250.9,2341.7,2376.2,2179.6,2147.2,2475.2,1.0245221993531315,0.03495124501259713,0.6422903530828887,0.1922686008480067,0.7480083159150468,0.12609357387893283,6276]
["A2AJT9-1","BCLAF1 and THRAP3 family member 3 [OS=Homo sapiens]",3,2,2,2,711,83.8,9.7,4.71,"other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","BCLAF3","ENSG00000173681","","","",99.8,101.7,109.8,210.3,232.3,338.7,0.3984384999360041,-1.327571037383098,0.016960625325106185,1.770558139683281,0.134891415126443,0.8700156891854193,919]
["A2RRP1-1","neuroblastoma-amplified sequence [OS=Homo sapiens]",17,31,67,31,2371,268.4,5.96,179.73,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","NBAS","ENSG00000151779","","COPI-dependent Golgi-to-ER retrograde traffic","",5045.9,5037.3,5171.1,4878.7,4713.7,6019.2,0.9771131722565275,-0.033402425633825186,0.7872400308953676,0.10389283028436154,0.8572612314979503,0.06688681622103242,6712]
["A2RTX5","Probable threonine--tRNA ligase 2, cytoplasmic [OS=Homo sapiens]",20,13,26,11,802,92.6,6.05,55.39,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","other molecular function","TARS3","ENSG00000185418","Aminoacyl-tRNA biosynthesis","","",1145.6,1141.5,1140.4,1143.6,1083.2,1076.6,1.0375673548465216,0.0532049936633768,0.1250830707076233,0.9028014656525869,0.35979227225581223,0.4439481688189832,2541]
["A2RU49","Hydroxylysine kinase [OS=Homo sapiens]",5,1,1,1,373,41.9,6.84,3.01,"other metabolic processes","mitochondrion","kinase activity","HYKK","ENSG00000188266","Lysine degradation; Metabolic pathways","Lysine catabolism","",25.3,35.3,25.5,35.9,27.7,126.8,0.4522058823529412,-1.1449483359110995,0.3373796352281546,0.47188113566201084,0.5481013011519409,0.26113916694360473,4499]
["A2RU67","Protein FAM234B [OS=Homo sapiens]",6,3,6,3,622,67,5.02,18.88,"","other membranes;cytoskeleton;ER/Golgi","","FAM234B","ENSG00000084444","","","",417.5,440.6,456.5,474,475.7,618.1,0.8384998086490624,-0.25411764032979833,0.16059374762353135,0.7942713670614292,0.4004707271853943,0.3974292236158917,2931]
["A2RUC4","tRNA wybutosine-synthesizing protein 5 [OS=Homo sapiens]",7,2,4,2,315,36.5,7.55,10.06,"RNA metabolism OR transcription;other metabolic processes","other cell component","nucleic acid binding activity;other molecular function","TYW5","ENSG00000162971","","Synthesis of wybutosine at G37 of tRNA(Phe)","",254.9,273.3,238.9,249.7,247.3,250.2,1.026632762312634,0.03792020625314321,0.5425755716049091,0.2655397633868323,0.6803370823229166,0.16727585682230425,5829]
["A2RUR9","Coiled-coil domain-containing protein 144A [OS=Homo sapiens]",2,3,7,2,1427,165,5.36,13.7,"","","","CCDC144A","ENSG00000170160","","","",122,121.6,125,107,121.1,198.6,0.8638387625966722,-0.21116603957039806,0.5340356839997675,0.2724297226598019,0.6737902320653031,0.17147528927488612,5793]
["A2RUS2","DENN domain-containing protein 3 [OS=Homo sapiens]",9,7,10,7,1198,135.8,7.06,23.16,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol;other cell component","enzyme regulator activity","DENND3","ENSG00000105339","","RAB GEFs exchange GTP for GDP on RABs","",707.3,714.6,707.9,735.7,702.1,775.8,0.9621431152873147,-0.05567658929270553,0.26239511889079153,0.5810442480254606,0.5012665770969147,0.2999312518327646,3826]
["A3KMH1","von Willebrand factor A domain-containing protein 8 [OS=Homo sapiens]",14,19,30,19,1905,214.7,7.4,99.05,"","mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","VWA8","ENSG00000102763","","","",3170.8,3018.4,3164.7,2826.6,2908.5,3020.7,1.0683090066013388,0.09532900452673182,0.056795044477500216,1.2456895560137102,0.24476119108847233,0.6112574420504323,1696]
["A3KN83-1","protein strawberry notch homolog 1 [OS=Homo sapiens]",6,5,8,5,1393,154.2,7.88,19.95,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","SBNO1","ENSG00000139697","","","",107,111.9,114.6,119.2,118,125.7,0.9189859465417471,-0.12188529540738667,0.03992966505748402,1.3987043327882955,0.20786746574440934,0.682213478698109,1404]
["A4D1E9-1","GTP-binding protein 10 [OS=Homo sapiens]",26,8,19,8,387,42.9,9.03,60.89,"other biological processes","mitochondrion;nucleus;other cell component","other molecular function","GTPBP10","ENSG00000105793","","","",1677.7,1715.4,1742.5,1626,1598.6,2402.9,0.9125899600177699,-0.1319613130216696,0.5686338579923291,0.24516728481184438,0.6979252507247579,0.1561910887466678,5955]
["A4D1P6-1","WD repeat-containing protein 91 [OS=Homo sapiens]",18,10,19,10,747,83.3,6.58,71.16,"transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle","enzyme regulator activity","WDR91","ENSG00000105875","","CDC42 GTPase cycle","",1840,1888,1906.3,1910,1861.6,1666.9,1.0360025742392205,0.051027587809740406,0.44372026633295875,0.35289073500765145,0.6122619268694725,0.2130627460592762,5297]
["A5A3E0","POTE ankyrin domain family member F [OS=Homo sapiens]",13,11,339,2,1075,121.4,6.2,1022.65,"","other cell component","","POTEF","ENSG00000196604","","","",452.3,450.3,571.2,364.9,434.4,225.5,1.4381342701014834,0.5241983779791937,0.11064286943667305,0.9560765696634441,0.34007095572440843,0.468430458062144,2378]
["A5LHX3","proteasome subunit beta type-11 [OS=Homo sapiens]",5,1,1,1,300,32.5,6.46,2.88,"protein metabolism;other metabolic processes;developmental processes","cytosol;nucleus;other cell component","other molecular function","PSMB11","ENSG00000222028","Proteasome","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling","",30.5,25.7,43.5,33.2,26.9,108.3,0.5920427553444181,-0.7562267286682002,0.439133065884623,0.35740386011591596,0.6078832535133919,0.21617982076575526,5280]
["A5PLN9-1","Trafficking protein particle complex subunit 13 [OS=Homo sapiens]",4,2,4,2,417,46.5,5.6,9.61,"","cytosol;ER/Golgi","","C5orf44; TRAPPC13","ENSG00000113597","","RAB GEFs exchange GTP for GDP on RABs","",446,496.1,462.8,481.4,491.6,621,0.8813676286072772,-0.18218418545761303,0.25333299501915785,0.5963082424181251,0.4942901389735784,0.3060180535733707,3746]
["A5YKK6","CCR4-NOT transcription complex subunit 1 [OS=Homo sapiens]",19,40,103,40,2376,266.8,7.11,284.22,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","CNOT1","ENSG00000125107","RNA degradation","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","Ciliary landscape",8461.2,8380,8645.2,9575.5,9325.3,14309,0.7674361182542502,-0.3818814300247269,0.187879411507154,0.7261208088230229,0.43223500746168986,0.3642800617661974,3177]
["A6NC62","Putative RBAK downstream neighbor protein [OS=Homo sapiens]",6,1,1,1,111,12.3,8.76,2.34,"","","","RBAKDN","","","","",157.5,139.6,166.2,161.9,173.2,181.8,0.8963048945637452,-0.1579385199128333,0.13996298187837897,0.8539868135488724,0.3786045279604263,0.4218141963509112,2702]
["A6NC98","Coiled-coil domain-containing protein 88B [OS=Homo sapiens]",41,50,114,50,1476,164.7,5.11,346.24,"cell organization and biogenesis;stress response;transport;other biological processes","cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","CCDC88B","ENSG00000168071","","","",8349.9,8187.6,8153.7,9566.4,9578.2,10639.8,0.8289977303554881,-0.27055994299669167,0.009285416357644414,2.0321986177428992,0.10114323123401343,0.9950631760279184,671]
["A6ND36-1","Protein FAM83G [OS=Homo sapiens]",3,2,2,2,823,90.8,6.39,5.4,"signal transduction","cytosol;nucleus","other molecular function","FAM83G","ENSG00000188522","","","",47.5,61.2,61.9,76.3,65,124.5,0.6418359668924002,-0.6397234579578845,0.1673370258407844,0.7764079542006365,0.4090522815619709,0.38822118064109323,2990]
["A6NDG6","glycerol-3-phosphate phosphatase [OS=Homo sapiens]",38,10,26,10,321,34,6.14,84.02,"protein metabolism;other metabolic processes;other biological processes","other cell component","other molecular function","PGP","ENSG00000184207","Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism","Glycolysis","",3461.9,3362.1,3363.6,3260.2,3459.1,3532.5,0.9937376850894478,-0.009063018114170743,0.8194018391747997,0.08650306559331052,0.8776389276859042,0.056684121868804206,6824]
["A6NDU8","UPF0600 protein C5orf51 [OS=Homo sapiens]",42,8,16,8,294,33.6,5.26,52.53,"","cytosol;nucleus","","C5orf51","ENSG00000205765","","","",1402.6,1354.8,1459.5,1512.7,1549.9,888.6,1.0672453938044135,0.09389193597522548,0.7035959548007182,0.1526766661059585,0.7912883264561393,0.10166524118905683,6499]
["A6NED2","RCC1 domain-containing protein 1 [OS=Homo sapiens]",7,1,2,1,376,40.1,5.27,8.95,"cell organization and biogenesis","plasma membrane;other membranes;cytosol;other cell component","","RCCD1","ENSG00000166965","","","",15.4,12.8,13.8,10.1,13.5,17.5,1.021897810218978,0.031250933984439545,0.9011807233846226,0.045188106581168196,0.9372125650566601,0.028161897520452582,7028]
["A6NEE1","Pleckstrin homology domain-containing family D member 1 [OS=Homo sapiens]",1,1,3,1,506,59.2,6.44,6.54,"","","","PLEKHD1","ENSG00000175985","","","",464.6,498.4,462.8,566.3,547.1,640.4,0.8129775344965218,-0.2987126089071942,0.023585427716797502,1.6273562435072915,0.1584429146894053,0.8001271769854796,1088]
["A6NF36","Coiled-coil domain-containing protein 182 [OS=Homo sapiens]",5,1,1,1,153,17.5,6.58,2.1,"developmental processes","","","CCDC182","ENSG00000166329","","","",335.9,381.3,319.3,299.4,278.1,163,1.399729912221472,0.4851484758205669,0.09978403195619939,1.0009389515799312,0.32588091580333395,0.4869410718882894,2238]
["A6NFI3","Zinc finger protein 316 [OS=Homo sapiens]",1,1,1,1,1004,108.4,5.31,1.81,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF316","ENSG00000205903","Herpes simplex virus 1 infection","","",97.9,94.9,97.2,130.7,138,329.6,0.48470666889520314,-1.0448161627526587,0.18969955115603937,0.7219336966848006,0.43505303401301904,0.36145779827456026,3187]
["A6NFQ2","TRPM8 channel-associated factor 2 [OS=Homo sapiens]",10,7,10,7,919,100.8,7.17,35.62,"other biological processes","plasma membrane;other membranes;other cell component","other molecular function","TCAF2","ENSG00000170379","","","",791,732.1,769.3,721.7,739.8,932.8,0.9574405880633169,-0.06274512844062471,0.6515613544964168,0.18604468253829845,0.7530458475670953,0.12317858191449695,6324]
["A6NHR9-1","structural maintenance of chromosomes flexible hinge domain-containing protein 1 [OS=Homo sapiens]",19,35,74,35,2005,226.2,7.3,199.26,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SMCHD1","ENSG00000101596","","","",8978.5,8954.6,8990.1,9475,9740.7,10286.6,0.9125796971761523,-0.13197753743198565,0.022856183753201094,1.6409962810834655,0.15583567822028618,0.8073331045562437,1072]
["A6NI79","Coiled-coil domain-containing protein 69 [OS=Homo sapiens]",15,5,6,5,296,34.8,5.76,11.39,"cell cycle OR cell proliferation;cell organization and biogenesis","cytoskeleton;nucleus;other cell component","cytoskeletal activity","CCDC69","ENSG00000198624","","","",546.3,544.2,571.7,518.2,518.1,400.8,1.1566348897084406,0.20993352655805875,0.13466966375570033,0.8707302242272866,0.37199568117551535,0.42946210219479586,2646]
["A6NIH7","Protein unc-119 homolog B [OS=Homo sapiens]",35,5,10,5,251,28.1,5.68,36.45,"cell organization and biogenesis;transport;developmental processes","cytosol;other cell component","other molecular function","UNC119B","ENSG00000175970","","Trafficking of myristoylated proteins to the cilium","",787.2,819.4,801.6,801.2,836.9,1088.4,0.8832569227947917,-0.1790949431659152,0.3077331333395314,0.5118257411531302,0.531103062946549,0.274821193935883,4235]
["A6NJ78","Probable methyltransferase-like protein 15 [OS=Homo sapiens]",16,4,5,4,407,46.1,8.62,15.12,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","other molecular function","METTL15","ENSG00000169519","","","",176.2,176,191.1,170.3,160.6,214.8,0.9956019791094007,-0.006358996701318492,0.9655714049029008,0.015215604216388337,0.9774738778996264,0.009894839902054482,7220]
["A6NK58","Putative lipoyltransferase 2, mitochondrial [OS=Homo sapiens]",4,1,1,1,231,25.2,8.27,2.54,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","other molecular function","LIPT2","ENSG00000175536","Lipoic acid metabolism; Metabolic pathways; Biosynthesis of cofactors","Glyoxylate metabolism and glycine degradation","",67.1,72.3,72.8,78.9,84.2,198.5,0.5868362831858407,-0.7689700215004229,0.27130173667135843,0.5665474262001664,0.5076662553330668,0.29442170326802897,3906]
["A6NK97-2","Isoform 2 of Solute carrier family 22 member 20 [OS=Homo sapiens]",5,1,1,1,347,37,7.78,0,"","","","SLC22A20P","","","","",26,26.2,34.5,25,16.6,38.5,1.0823970037453186,0.11422975081312516,0.7679504326810123,0.1146668105776386,0.8422793686172748,0.07454383709239676,6664]
["A6NKF1","SAC3 domain-containing protein 1 [OS=Homo sapiens]",7,2,2,2,404,43.5,8.69,6.58,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;nucleus;other cell component","","SAC3D1","","","","",178.7,173.6,197,223.8,183.7,237.9,0.8511000929656027,-0.23259928596844875,0.14495149131352417,0.8387773121068272,0.38192157534626825,0.4180258069601203,2774]
["A7E2V4","Zinc finger SWIM domain-containing protein 8 [OS=Homo sapiens]",6,6,7,6,1837,197.2,6.8,22.41,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","other molecular function","ZSWIM8","ENSG00000214655","","Regulation of expression of SLITs and ROBOs","",460.7,455.9,470.5,590.7,586.6,896.1,0.6689977814218192,-0.5799266683809348,0.08959842235324211,1.04769963731682,0.30716457269223574,0.5126288757873816,2132]
["A8MVU1","Putative neutrophil cytosol factor 1C [OS=Homo sapiens]",33,8,20,8,366,41.8,8.84,66.73,"other metabolic processes","other cell component","enzyme regulator activity;other molecular function","NCF1C","","","","",1331.6,1267.8,1389.6,1575.4,1490.5,2348.5,0.7367390661938533,-0.4407743501454243,0.15934435756968027,0.7976633104126389,0.3992622247092194,0.3987417776503987,2917]
["A8MW92","PHD finger protein 20-like protein 1 [OS=Homo sapiens]",1,1,1,1,1017,114.9,6.83,2.6,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","PHF20L1","ENSG00000129292","","","",50.8,60.8,49.2,77.4,78,64.2,0.73224043715847,-0.44961064782626997,0.02756240683640066,1.5596828611429339,0.17277326892560244,0.7625234496819562,1166]
["A8MXV4","nucleoside diphosphate-linked moiety X motif 19 [OS=Homo sapiens]",12,2,13,2,375,42.2,7.64,35.47,"other metabolic processes","cytosol;other cytoplasmic organelle","other molecular function","NUDT19","ENSG00000213965","Peroxisome","Peroxisomal lipid metabolism; Peroxisomal protein import","",1144.6,1163.1,1076.6,968.4,908.5,307.5,1.5493041567478483,0.6316203993606563,0.13315925224772734,0.8756286522777437,0.3699205528995208,0.4318915384794736,2631]
["A9UHW6","MIF4G domain-containing protein [OS=Homo sapiens]",18,4,6,4,222,25.4,5.33,20.28,"other biological processes","cytosol;ER/Golgi;nucleus","nucleic acid binding activity;other molecular function","MIF4GD","ENSG00000125457","","","",440.2,422.5,472.4,574.4,609.8,916,0.6357013617750691,-0.6535789159668445,0.08019973865797615,1.0958270469226168,0.28918593480569693,0.5388228337316525,2027]
["B2RTY4","unconventional myosin-IXa [OS=Homo sapiens]",1,3,4,3,2548,292.5,8.88,9.32,"cell organization and biogenesis;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","MYO9A","ENSG00000066933","","RHOA GTPase cycle; RHOB GTPase cycle; RHOV GTPase cycle","",190.7,225.8,218.3,203.7,199,631.4,0.6138671308384103,-0.7040016712532436,0.4069065109851833,0.39050536086602267,0.5852183567081277,0.23268205969640024,5082]
["B5ME19","eukaryotic translation initiation factor 3 subunit C-like protein [OS=Homo sapiens]",44,41,177,1,914,105.4,5.64,520.95,"cell organization and biogenesis;protein metabolism;other metabolic processes","translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3CL","ENSG00000205609","","","",559.6,563,567.4,681.2,692.4,1038.4,0.7006633499170813,-0.5132066607305379,0.10940319830381733,0.960969981609572,0.33810908093133224,0.4709431647994295,2365]
["B7ZC32","Kinesin-like protein KIF28P [OS=Homo sapiens]",1,1,1,1,967,108.2,8.43,1.83,"cell organization and biogenesis;transport;other biological processes","other membranes;cytoskeleton;mitochondrion","cytoskeletal activity;other molecular function","KIF28P","","","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",89.2,87.5,85.6,74.7,69.1,108,1.0416997617156472,0.05893952454596744,0.7882103812485766,0.10335784948908885,0.8578066820348192,0.06661057507112707,6716]
["B9A064-1","Immunoglobulin lambda-like polypeptide 5 [OS=Homo sapiens]",48,8,196,8,214,23,8.84,691.91,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","IGLL5","ENSG00000254709","","","",29721.6,29804.1,32650.7,42363.8,37975.4,53210.2,0.6902045235695553,-0.5349041657242228,0.04076767202776616,1.3896840875265315,0.21013463670729401,0.6775023564896062,1418]
["C9J798","Ras GTPase-activating protein 4B [OS=Homo sapiens]",17,12,17,12,803,90.4,7.74,47.22,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol","enzyme regulator activity;other molecular function","RASA4B","ENSG00000170667","","","Ras signaling",1867.3,1791.4,1896,1996.9,2038.5,2414.6,0.8611937984496124,-0.21559016434901068,0.0940089240494415,1.0268309178740367,0.31591320729993927,0.5004322172807198,2175]
["C9JI98","Transmembrane protein 238 [OS=Homo sapiens]",6,1,1,1,176,18,11.53,2.83,"","other membranes","","TMEM238","ENSG00000233493","","","",169.7,158.6,156.5,141.9,164.1,152,1.0585152838427947,0.08204210048864455,0.30570156027940953,0.5147023446595556,0.5298488745748646,0.27584798379044606,4217]
["C9JRZ8","Aldo-keto reductase family 1 member B15 [OS=Homo sapiens]",5,2,7,1,316,36.5,6.7,14.99,"other metabolic processes","cytosol;mitochondrion","other molecular function","AKR1B15","ENSG00000227471","","Estrogen biosynthesis","",610.3,633.5,574.1,428.9,324.6,145.3,2.022585669781932,1.0162008115561045,0.022331474621865542,1.6510825980663097,0.1542729187251562,0.8117103038815038,1058]
["L0R6Q1","SLC35A4 upstream open reading frame protein [OS=Homo sapiens]",47,5,18,5,103,11.1,8.1,62.31,"stress response","other membranes","","SLC35A4","ENSG00000176087","","","",2705.6,2573.2,2335.7,1898.8,2251.4,1431.4,1.3642145621327215,0.44807056766186876,0.060267491868674514,1.2199168820389752,0.2511374561391916,0.600088509185024,1754]
["O00115","Deoxyribonuclease-2-alpha [OS=Homo sapiens]",10,4,11,4,360,39.6,8.05,21.95,"cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes","other cytoplasmic organelle","nucleic acid binding activity;other molecular function","DNASE2","ENSG00000105612","Lysosome","Lysosome Vesicle Biogenesis","",1271.1,1140.7,1384.8,1199.4,1293.7,1838.2,0.876549765659271,-0.19009209331305796,0.44624955204750616,0.3504222068313333,0.6126292216219426,0.2128022917499979,5324]
["O00116","Alkyldihydroxyacetonephosphate synthase, peroxisomal [OS=Homo sapiens]",36,17,47,17,658,72.9,7.34,166.8,"other metabolic processes","cytosol;nucleus;other cytoplasmic organelle","other molecular function","AGPS","ENSG00000018510","Ether lipid metabolism; Metabolic pathways; Peroxisome","Plasmalogen biosynthesis; TYSND1 cleaves peroxisomal proteins","Triacylglyceride synthesis",4547.4,4547.9,4665.9,4356.3,4094.6,5517,0.9852017840906651,-0.021508854488141223,0.882854738934962,0.05411074746280604,0.9244678061426415,0.03410820820199417,6980]
["O00124-1","UBX domain-containing protein 8 [OS=Homo sapiens]",8,1,1,1,270,30.5,7.78,3.78,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","UBXN8","ENSG00000104691; ENSPTRG00000049759","Protein processing in endoplasmic reticulum","","",13.8,19.3,16,20.3,12.5,31.2,0.7671875,-0.38234888057266925,0.42927248445162564,0.3672669480772784,0.5996851278396277,0.22207672150951624,5232]
["O00139","Kinesin-like protein KIF2A [OS=Homo sapiens]",38,19,40,1,706,79.9,6.68,110.76,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KIF2A","ENSG00000068796","","COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Kinesins; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",3607.7,3627.1,3614.3,3818.6,3718.5,4630,0.8916750910241552,-0.1654099788656616,0.2026656162236125,0.6932199264476063,0.4475175193288169,0.3491899583393521,3310]
["O00139-2","Isoform 2 of Kinesin-like protein KIF2A [OS=Homo sapiens]",39,19,42,1,660,75,6.4,112.68,"","","","KIF2A","","","","",157.2,180.4,175.3,167.5,193,471.5,{"$f":"AVERAGE(S66:U66)/AVERAGE(V66:X66)","v":0.6164663461538463},{"$f":"LOG(Y66,2)","v":-0.6979059570511366},{"$f":"TTEST(V66:X66,S66:U66,2,2)","v":0.33711779819927673},0.4722183182126808,{"$f":"AA66*7309/AE66","v":0.5480413672238688},0.26118665888971243,4496]
["O00142","thymidine kinase 2, mitochondrial [OS=Homo sapiens]",15,3,5,3,265,31,8.46,13.08,"DNA metabolism;other metabolic processes","mitochondrion;other cell component","kinase activity;other molecular function","TK2","ENSG00000166548","Pyrimidine metabolism; Drug metabolism; Metabolic pathways","Pyrimidine salvage","Pyrimidine metabolism",462.9,469.5,475.6,454.1,439.1,490.1,1.0178558519482395,0.025533262391575585,0.6249458115415321,{"$f":"-LOG10(AA67)","v":0.20415763828594155},0.7364928952849175,{"$f":"-LOG10(AC67)","v":0.13283143830327615},6202]
["O00148","ATP-dependent RNA helicase DDX39A [OS=Homo sapiens]",56,22,194,9,427,49.1,5.68,472.72,"RNA metabolism OR transcription;other metabolic processes;transport","nucleus;other cell component","other molecular function","DDX39A","ENSG00000123136","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","",25010.5,24753.2,24684.3,25702.3,23819.2,21174.1,1.0530782679544413,0.07461266579712529,0.3960529917810059,0.4022467017048603,0.5772186075627861,0.23865967717732425,5015]
["O00151","PDZ and LIM domain protein 1 [OS=Homo sapiens]",73,16,96,16,329,36,7.02,326.94,"cell organization and biogenesis;stress response;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","PDLIM1","ENSG00000107438","","","",11333.7,11395.9,11014.8,12502.6,13141.8,10253.8,0.9400025628025916,-0.08926340475926865,0.4621407674051331,0.3352257188257042,0.6219456580674125,0.2062475597343588,5431]
["O00154","cytosolic acyl coenzyme A thioester hydrolase [OS=Homo sapiens]",39,14,70,14,380,41.8,8.54,221.44,"other metabolic processes","cytosol;mitochondrion;nucleus","other molecular function","ACOT7","ENSG00000097021","Fatty acid elongation; Biosynthesis of unsaturated fatty acids","Mitochondrial Fatty Acid Beta-Oxidation","",6466,6530.3,6318,5621.5,5603.7,6431.7,1.09386698684367,0.1294373184889641,0.1199584455075148,0.9209691707208023,0.35169525800819323,0.4538334873406027,2493]
["O00159-1","Unconventional myosin-Ic [OS=Homo sapiens]",24,25,63,25,1063,121.6,9.41,176.7,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","MYO1C","ENSG00000197879","Pathogenic Escherichia coli infection","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Translocation of SLC2A4 (GLUT4) to the plasma membrane","VEGFA-VEGFR2 signaling pathway; Insulin signaling",9348.2,9571.7,8942.7,8970.4,8543.7,8856.5,1.0565781590104133,0.07939949273049425,0.090556748237754,1.0430791807644062,0.30900059424357795,0.51004068537627,2142]
["O00161","Synaptosomal-associated protein 23 [OS=Homo sapiens]",57,11,42,11,211,23.3,5.01,126.62,"cell-cell signaling;cell organization and biogenesis;stress response;transport","plasma membrane;other membranes;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","SNAP23","ENSG00000092531","SNARE interactions in vesicular transport; Platelet activation","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; ER-Phagosome pathway; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; trans-Golgi Network Vesicle Budding","Insulin signaling",4122.7,4291.9,4345.7,3792.4,4336.9,4031.3,1.0493150009045609,0.06944783523055358,0.3080552887414311,0.5113713307709024,0.53128270538252,0.2746743212617052,4238]
["O00165","HCLS1-associated protein X-1 [OS=Homo sapiens]",45,10,25,10,279,31.6,4.92,86.17,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","HAX1","ENSG00000143575","","","",2561.4,2489.4,2495.6,2995.9,3300.3,4735.6,0.6840588117986185,-0.5478077290704342,0.09646953428469256,1.0156098180661395,0.319336877756711,0.4957509252393278,2208]
["O00170","AH receptor-interacting protein [OS=Homo sapiens]",27,7,27,7,330,37.6,6.29,89.27,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","AIP","ENSG00000110711","Cushing syndrome; Chemical carcinogenesis","Aryl hydrocarbon receptor signalling; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","Aryl hydrocarbon receptor Netpath; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway",2823.9,3261.3,2778.6,3532,3435.6,3761.4,0.8261534159753938,-0.2755183811421602,0.026748670840074536,1.572697793499308,0.17030142436420276,0.7687817196772899,1148]
["O00178","GTP-binding protein 1 [OS=Homo sapiens]",34,16,39,16,669,72.4,8.34,131.59,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;other cytoplasmic organelle","nucleic acid binding activity;other molecular function","GTPBP1","ENSG00000100226","","","",3330.3,3404,3333.8,3173.6,3308.3,3119.7,1.0485856523912682,0.06844471096540168,0.06337741089899347,1.1980655066295876,0.2545195034399688,0.5942789327306893,1820]
["O00186","syntaxin-binding protein 3 [OS=Homo sapiens]",19,9,24,9,592,67.7,7.8,66.92,"cell adhesion;cell-cell signaling;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","STXBP3","ENSG00000116266","","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Disinhibition of SNARE formation","Insulin signaling",2214.4,2246.2,2249.1,2164.9,2140.5,2261.8,1.0216987452795714,0.030969870678639433,0.286693803732793,0.5425816932890799,0.5184178652852509,0.2853200405843921,4042]
["O00189","AP-4 complex subunit mu-1 [OS=Homo sapiens]",7,3,3,3,453,49.9,7.2,9.07,"transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","AP4M1","ENSG00000221838","Lysosome","Lysosome Vesicle Biogenesis","",218.9,228.6,231.1,210,207.8,360.2,0.8722365038560412,-0.19720872516257745,0.5481411097227102,0.2611076253019866,0.6835631071426871,0.1652213847996325,5861]
["O00193","Small acidic protein [OS=Homo sapiens]",33,6,29,6,183,20.3,4.72,110.48,"","","","SMAP","ENSG00000110696","","","",2758.8,2765.9,2759.2,3074.4,3436.3,3777.8,0.8051611022014873,-0.3126506183764111,0.030213350826774028,1.5198011064090293,0.18115617817300358,0.7419468501434383,1219]
["O00203-1","AP-3 complex subunit beta-1 [OS=Homo sapiens]",36,36,116,35,1094,121.2,6.04,322.39,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","AP3B1","ENSG00000132842","Lysosome","Golgi Associated Vesicle Biogenesis; Signaling by BRAF and RAF1 fusions","",17237.9,17502.8,16927.4,15594.9,15066.6,11748.1,1.2183114200558365,0.2848829565144867,0.06402599959431392,1.193643632462721,0.255579481723015,0.5924740148804446,1831]
["O00214-1","Galectin-8 [OS=Homo sapiens]",10,3,6,3,317,35.8,8.25,21.56,"other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;cytosol;other cell component","signal transduction activity or receptor binding;other molecular function","LGALS8","ENSG00000116977","","","",385.3,409.8,396.7,443.3,400.6,1220.6,0.5772826350205861,-0.7926502659499035,0.33652209243474784,0.4729864193818889,0.5478040030301942,0.2613747985012391,4490]
["O00217","NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [OS=Homo sapiens]",31,6,19,6,210,23.7,6.34,49.75,"cell organization and biogenesis;other metabolic processes;stress response;transport","other membranes;mitochondrion","transporter activity;other molecular function","NDUFS8","ENSG00000110717","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",2087.6,2834,1944.3,2671.5,2675.8,2494.1,0.8755961945570946,-0.19166241047533095,0.3134318096775971,0.5038569297997553,0.5357514258497561,0.2710366644525227,4276]
["O00221","NF-kappa-B inhibitor epsilon [OS=Homo sapiens]",22,7,15,7,500,52.8,6.68,46.7,"other biological processes","cytosol;nucleus;other cell component","","NFKBIE","ENSG00000146232","Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; Neurotrophin signaling pathway; Adipocytokine signaling pathway; Epstein-Barr virus infection; PD-L1 expression and PD-1 checkpoint pathway in cancer","Activation of NF-kappaB in B cells","TNF-alpha signaling pathway; Apoptosis; Oxidative damage response; Canonical NF-kB pathway; IL-18 signaling pathway; STING pathway in Kawasaki-like disease and COVID-19",1157,1194.1,1335.3,1579.3,1686.8,5556.6,0.41783127613995713,-1.259007607644609,0.26109997705956156,0.5831931663344905,0.5011501397921049,0.3000321441629543,3808]
["O00231","26S proteasome non-ATPase regulatory subunit 11 [OS=Homo sapiens]",69,27,96,26,422,47.4,6.48,321.34,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","PSMD11","ENSG00000108671","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection","Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling pathway",15070.1,15138.7,15500.8,17054.6,15760.9,19822.4,0.8683781077892546,-0.20360473948012944,0.12786035298614107,0.8932641009367106,0.3625024515033767,0.4406890520701218,2578]
["O00232-1","26s proteasome non-atpase regulatory subunit 12 [OS=Homo sapiens]",61,28,163,28,456,52.9,7.65,457.29,"protein metabolism;other metabolic processes","non-structural extracellular;cytosol;nucleus;other cell component","","PSMD12","ENSCANG00000030312; ENSCATG00000032968; ENSCSAG00000004164; ENSG00000197170; ENSMFAG00000032701; ENSMLEG00000034943; ENSMMUG00000002132; ENSMNEG00000032475; ENSNLEG00000001265; ENSPANG00000020562; ENSPPYG00000008565; ENSRROG00000042400","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection","Activation of NF-kappaB in B cells; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease",16058.8,16928.6,15844.9,15355.9,13956.8,11641,1.1923782222363304,0.253841931097067,0.08128294334914433,1.0900005784712359,0.29122403575436073,0.5357727840131618,2040]
["O00233-1","26S proteasome non-ATPase regulatory subunit 9 [OS=Homo sapiens]",30,6,24,6,223,24.7,6.95,72.5,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PSMD9","ENSG00000110801","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease",2257.5,2494.2,2116.4,2237.1,2323,2075.8,1.0349914857065357,0.04961889953186392,0.5888628240365452,0.22998586260242077,0.7110521032352733,0.1480985746309998,6053]
["O00244","Copper transport protein ATOX1 [OS=Homo sapiens]",40,3,9,3,68,7.4,7.24,33.66,"stress response;transport;other biological processes","cytosol","other molecular function","ATOX1","ENSG00000177556","Mineral absorption","Detoxification of Reactive Oxygen Species; Ion influx/efflux at host-pathogen interface","Copper homeostasis",1118.6,1266.6,1105.4,1138.8,1217.3,991.6,1.0426860232398365,0.06030479457076321,0.6007396686749543,0.22131368931480627,0.7185086300679497,0.1435680111506599,6111]
["O00255-1","Menin [OS=Homo sapiens]",23,10,17,10,615,68,6.55,59.91,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","MEN1","ENSG00000133895","Cushing syndrome; Transcriptional misregulation in cancer","RHO GTPases activate IQGAPs; Formation of the beta-catenin:TCF transactivating complex; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",1342.3,1299.5,1374,1427.1,1456.8,1922,0.8355979109011842,-0.2591192093950615,0.17868662119756626,0.7479079632055186,0.4215689200558463,0.3751314147447328,3098]
["O00257-1","E3 SUMO-protein ligase CBX4 [OS=Homo sapiens]",5,2,3,2,560,61.3,9.36,8.25,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","CBX4","ENSG00000141582; ENSPTRG00000040905","","SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Oxidative Stress Induced Senescence; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN gene transcription","",196,191.5,223.2,201.9,223.2,266,0.8836637244971784,-0.17843063397927716,0.2765717429259492,0.5581921934176606,0.5111157696702308,0.291480719367383,3955]
["O00258-1","Tail-anchored protein insertion receptor WRB [OS=Homo sapiens]",12,2,3,2,174,19.8,9.67,7.23,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;ER/Golgi;nucleus","","GET1; WRB","ENSANAG00000014374; ENSCANG00000035340; ENSCATG00000041953; ENSCCAG00000026562; ENSCSAG00000008355; ENSG00000182093; ENSMLEG00000038301; ENSMNEG00000036276; ENSNLEG00000033928; ENSPANG00000032093; ENSPPAG00000034665; ENSPPYG00000011427; ENSPTRG00000013915; ENSSBOG00000020756","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",366.2,359.3,398.5,346.9,358.3,271.4,1.150931804218718,0.20280235247082484,0.17480058477652272,0.7574571188137887,0.41629764553001125,0.38059604536163844,3069]
["O00264","Membrane-associated progesterone receptor component 1 [OS=Homo sapiens]",61,12,49,10,195,21.7,4.7,143.13,"other metabolic processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","PGRMC1","ENSG00000101856","","Neutrophil degranulation","",3574.8,4193.3,3491.5,3056.2,3665.6,2840.3,1.1775237657000033,0.235756177724713,0.16328475722854632,0.7870543551317092,0.4045587425706593,0.39301840922589926,2950]
["O00267","Transcription elongation factor Spt5 [OS=Homo sapiens]",35,32,126,32,1087,120.9,5.06,422.29,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","SUPT5H","ENSG00000196235","","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE","Initiation of transcription and translation elongation at the HIV-1 LTR; mRNA processing",11341.4,11324.6,11208.4,10375.5,10216.4,9399.7,1.129462916283226,0.17563690342460478,0.013246911446180705,1.877885366877166,0.12012614858577517,0.9203624467982837,806]
["O00268","Transcription initiation factor TFIID subunit 4 [OS=Homo sapiens]",8,6,7,6,1085,110,9.94,21.59,"RNA metabolism OR transcription;other metabolic processes;developmental processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","TAF4","ENSG00000130699","Basal transcription factors; Huntington disease","RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation","",619.6,656.7,680.5,777.7,756.3,749.8,0.856817584727209,-0.22294000562738428,0.005139885725336648,2.2890465365314574,0.07942373100736905,1.100049715385296,473]
["O00273-1","DNA fragmentation factor subunit alpha [OS=Homo sapiens]",50,11,30,3,331,36.5,4.79,101.46,"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","DFFA","ENSG00000160049","Apoptosis","Apoptosis induced DNA fragmentation","Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis",2942.7,2983.9,2983,3664.1,3806.5,5204,0.7029492054976094,-0.5085076497207746,0.06306918793633108,1.2001827608417972,0.2536998869711854,0.5956797262658586,1817]
["O00273-2","Isoform DFF35 of DNA fragmentation factor subunit alpha [OS=Homo sapiens]",55,9,25,1,268,29.4,4.61,92.3,"","","","DFFA","","","","",59.2,66.8,71.4,90.3,72.7,135,0.6624161073825503,-0.5941903408931264,0.15037849895800875,0.82281425451177,0.388655038502152,0.41043569775265887,2828]
["O00287","Regulatory factor X-associated protein [OS=Homo sapiens]",7,1,1,1,272,28.2,5.54,2.31,"other biological processes","nucleus","nucleic acid binding activity","RFXAP","ENSG00000133111","Antigen processing and presentation; Tuberculosis; Primary immunodeficiency","","",16.3,11.8,13.4,12.7,11.1,3.2,1.5370370370370374,0.6201519291834566,0.20755696215827327,0.6828626943442025,0.4528459213178565,0.34404953949707484,3350]
["O00291","Huntingtin-interacting protein 1 [OS=Homo sapiens]",4,3,3,2,1037,116.1,5.3,7.67,"cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","HIP1","ENSG00000127946","Huntington disease; Pathways of neurodegeneration","Clathrin-mediated endocytosis; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants","",87.7,88.3,91.8,94.5,91.5,141.6,0.8174603174603174,-0.29077939631669814,0.2878114112076785,0.5408919910586195,0.51877030937532,0.28502488772182133,4055]
["O00299","chloride intracellular channel protein 1 [OS=Homo sapiens]",86,18,273,17,241,26.9,5.17,1010.2,"other metabolic processes;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;mitochondrion;nucleus;other cell component","transporter activity","CLIC1","ENSG00000206394; ENSG00000213719; ENSG00000223639; ENSG00000226248; ENSG00000226417; ENSG00000226651; ENSG00000230685","","","VEGFA-VEGFR2 signaling pathway",30452.4,31187.7,29882.2,29428.6,30336.2,19887.3,1.1490255749691471,0.2004109097947588,0.3046466026011821,0.5162036607359229,0.529149719204382,0.2764214299976327,4208]
["O00300","Tumor necrosis factor receptor superfamily member 11B [OS=Homo sapiens]",2,1,1,1,401,46,8.29,2.56,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","TNFRSF11B","ENSG00000164761","Cytokine-cytokine receptor interaction; Osteoclast differentiation","TNFs bind their physiological receptors","Osteoclast signaling; RANKL/RANK signaling pathway; Ectoderm differentiation; Vitamin D receptor pathway; Osteoblast signaling; IL-18 signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta; Overlap between signal transduction pathways contributing to LMNA laminopathies; Monoamine transport",179.4,188,193.3,149.9,131.5,138,1.3369098712446355,0.418902208369722,2.2060296745598177E-3,2.656388649914458,0.05356767737992594,1.2710971836243283,301]
["O00303","Eukaryotic translation initiation factor 3 subunit F [OS=Homo sapiens]",47,12,71,12,357,37.5,5.45,236.86,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3F","ENSG00000175390","","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","Translation factors; VEGFA-VEGFR2 signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell",7071.4,7057.3,7170,7458,7639.6,7674.9,0.9352815896366231,-0.09652730549063074,2.946119582571574E-3,2.5307496291848492,0.06014856991345149,1.2207746939447508,358]
["O00308","NEDD4-like E3 ubiquitin-protein ligase WWP2 [OS=Homo sapiens]",9,6,6,6,870,98.9,7.12,10.1,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","WWP2","ENSG00000198373","Ubiquitin mediated proteolysis","RHOQ GTPase cycle; Regulation of PTEN stability and activity; RHOJ GTPase cycle; NOTCH3 Activation and Transmission of Signal to the Nucleus; RHOU GTPase cycle","",565.4,571.8,565.7,781,766,837.9,0.714034131410122,-0.48593505699262646,4.9476897316310352E-4,3.305597542685897,0.025830474463208023,1.5878676164801617,140]
["O00327-1","Isoform BMAL1A of Aryl hydrocarbon receptor nuclear translocator-like protein 1 [OS=Homo sapiens]",2,1,1,1,583,64.2,6.98,2.86,"","","","ARNTL","","","","",38.7,37.4,34.5,40.7,36.4,23.8,1.0961347869177405,0.13242521112834996,0.5692308686425855,0.24471155672964526,0.6983062133112886,0.15595409372469712,5958]
["O00330-1","Pyruvate dehydrogenase protein X component, mitochondrial [OS=Homo sapiens]",29,14,42,14,501,54.1,8.66,119.68,"other metabolic processes","mitochondrion;other cell component","other molecular function","PDHX","ENSG00000110435","Metabolic pathways","Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid","Amino acid metabolism",6427.3,6324.1,6464.4,6065,5880.9,8357.9,0.9464139717688316,-0.0794567227599382,0.6730093458342872,0.1719789048457442,0.7684776298551484,0.11436877015756164,6401]
["O00391","Sulfhydryl oxidase 1 [OS=Homo sapiens]",2,1,1,1,747,82.5,8.92,2.8,"cell organization and biogenesis;other biological processes","non-structural extracellular;other membranes;ER/Golgi;other cell component","other molecular function","QSOX1","ENSG00000116260","","Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",32.5,27.5,37,30.1,23.5,11.5,1.490015360983103,0.5753272039088547,0.15607755793270492,0.806659538748391,0.39541451332067257,0.4029473943561682,2885]
["O00399","Dynactin subunit 6 [OS=Homo sapiens]",22,4,9,4,190,20.7,6.32,21.9,"cell cycle OR cell proliferation;cell organization and biogenesis","cytosol;cytoskeleton;other cell component","other molecular function","DCTN6","ENSG00000104671","Vasopressin-regulated water reabsorption; Amyotrophic lateral sclerosis; Huntington disease; Pathways of neurodegeneration; Salmonella infection","MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic","",1062,1073.7,1068.2,1212.3,1218,2029.8,0.7183471222618325,-0.47724693809657165,0.1979662433207637,0.7034088581696294,0.4442539982902861,0.3523686548505296,3257]
["O00400","Acetyl-coenzyme A transporter 1 [OS=Homo sapiens]",23,12,40,12,549,60.9,7.33,119.98,"transport;signal transduction","plasma membrane;other membranes;ER/Golgi","transporter activity","SLC33A1","ENSG00000169359","Glycosphingolipid biosynthesis; Metabolic pathways","Transport of vitamins, nucleosides, and related molecules; Defective SLC33A1 causes spastic paraplegia 42 (SPG42)","Ganglio sphingolipid metabolism",4212.3,4571.6,4684,4236.2,3712.8,4514.2,1.0806133256306565,0.11185037784489792,0.2896752610699899,0.5380885929548809,0.5193123579005534,0.28457134252306465,4077]
["O00401","Neural Wiskott-Aldrich syndrome protein [OS=Homo sapiens]",2,1,1,1,505,54.8,7.93,1.92,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity","WASL","ENSG00000106299","Endocytosis; Adherens junction; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection","Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RHOJ GTPase cycle; RHOV GTPase cycle; NOSTRIN mediated eNOS trafficking; Nephrin family interactions; EPHB-mediated forward signaling; DCC mediated attractive signaling","Pathogenic Escherichia coli infection; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Chemokine signaling pathway; G13 signaling pathway",155.6,133.5,139.8,144.1,145.7,92,1.1233630172865376,0.1678242132316189,0.4511763323685441,0.34565369047714073,0.6162675786360846,0.21023067956742256,5351]
["O00410","Importin-5 [OS=Homo sapiens]",59,46,321,43,1097,123.6,4.94,1059.57,"transport;other biological processes","nucleus;other cell component","enzyme regulator activity;other molecular function","IPO5","ENSG00000065150","Nucleocytoplasmic transport","vRNP Assembly","",32437.5,32422.7,33006.3,32169.4,31506.5,24107.6,1.1148621324052925,0.1568653126630212,0.26433034106307846,0.5778529836712218,0.5018157046311794,0.2994557512957495,3850]
["O00411","DNA-directed RNA polymerase, mitochondrial [OS=Homo sapiens]",19,16,52,16,1230,138.5,8.98,169.38,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","POLRMT","ENSG00000099821","","Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis","Mitochondrial gene expression",2906.7,2875.7,3056.7,3221.2,3059.9,4222.6,0.8415225111151307,-0.24892623005848738,0.20604034009148378,0.6860477419416584,0.45142351490667115,0.3454158220233865,3336]
["O00418","Eukaryotic elongation factor 2 kinase [OS=Homo sapiens]",16,11,19,11,725,82.1,5.33,36.59,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;other cell component","nucleic acid binding activity;kinase activity;other molecular function","EEF2K","ENSG00000103319","AMPK signaling pathway; Oxytocin signaling pathway","mTORC1-mediated signalling","Translation factors; AMP-activated protein kinase (AMPK) signaling; BDNF-TrkB signaling",1613.3,1558.4,1688.1,1695.3,1608.5,2592.4,0.8242257725314607,-0.27888851925486713,0.3367031413080783,0.47275283179605043,0.5478546882949119,0.26133461750149767,4492]
["O00422","Histone deacetylase complex subunit SAP18 [OS=Homo sapiens]",52,8,41,8,153,17.6,9.35,77,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","SAP18","ENSG00000150459","Nucleocytoplasmic transport; mRNA surveillance pathway","Potential therapeutics for SARS; HDACs deacetylate histones; NoRC negatively regulates rRNA expression","Hedgehog signaling pathway Netpath",4459,4715.6,4563.3,4930.1,5002.2,4738.1,0.9364366343112663,-0.09474671970125198,0.0456529399554944,1.3405312495571626,0.2205402102674875,0.6565122156963764,1513]
["O00425","Insulin-like growth factor 2 mRNA-binding protein 3 [OS=Homo sapiens]",2,2,2,2,579,63.7,8.87,2.02,"protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","IGF2BP3","ENSG00000136231","","Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA","",149.2,179.2,142,160.9,155.1,86.3,1.169276659209545,0.22561632221073405,0.4404058567849817,0.3561469141496814,0.6091836501213912,0.21525176120819803,5284]
["O00429","Dynamin-1-like protein [OS=Homo sapiens]",70,45,189,1,736,81.8,6.81,589.96,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","DNM1L","ENSG00000087470","Necroptosis; NOD-like receptor signaling pathway; TNF signaling pathway","Apoptotic execution phase","Synaptic vesicle pathway; CAMKK2 pathway",19206.7,19137.7,19461,18290.6,17781.6,15240.3,1.126536419001218,0.17189395419753384,0.08462918058799422,1.0724798641094369,0.29838624260378666,0.5252212043193248,2073]
["O00429-2","Isoform 4 of Dynamin-1-like protein [OS=Homo sapiens]",71,45,192,1,725,80.5,6.71,609.4,"","","","DNM1L","","","","",398.3,377.8,382.7,402.7,419.6,447.6,0.9125127962831718,-0.1320833047691733,0.0627821390917666,1.2021638912494819,0.25324208312457064,0.5964641227063032,1812]
["O00442","RNA 3'-terminal phosphate cyclase [OS=Homo sapiens]",44,14,51,14,366,39.3,7.85,155.6,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","RTCA","ENSG00000137996","","","",4440.7,4361.2,4599.6,4173.4,3915.1,3798.1,1.1274460316659096,0.17305837653039782,0.018303390490414944,1.7374684548110657,0.1411175960911844,0.8504188302651591,948]
["O00443","phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [OS=Homo sapiens]",16,23,31,23,1686,190.6,8.02,87.31,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","PIK3C2A","ENSG00000011405","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Salmonella infection","Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane","Glioblastoma signaling pathways; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; Osteoblast differentiation and related diseases; Insulin signaling; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)",2247.5,2462.1,2438.4,2998.7,3003.3,3676.6,0.7385365652057114,-0.4372587437889276,0.023042673694237233,1.637467130141001,0.1566687460755162,0.8050176325086523,1075]
["O00459","Phosphatidylinositol 3-kinase regulatory subunit beta [OS=Homo sapiens]",6,3,5,3,728,81.5,6.43,10.37,"other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;cytosol;nucleus","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","PIK3R2","ENSG00000105647","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; Platinum drug resistance; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Phosphatidylinositol signaling system; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Osteoclast differentiation; Focal adhesion; Signaling pathways regulating pluripotency of stem cells; Platelet activation; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; TNF signaling pathway; Leukocyte transendothelial migration; Neurotrophin signaling pathway; Cholinergic synapse; Inflammatory mediator regulation of TRP channels; Regulation of actin cytoskeleton; Insulin signaling pathway; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Prolactin signaling pathway; Thyroid hormone signaling pathway; Regulation of lipolysis in adipocytes; Relaxin signaling pathway; GnRH secretion; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Aldosterone-regulated sodium reabsorption; Carbohydrate digestion and absorption; Alzheimer disease; Spinocerebellar ataxia; Prion disease; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection; Chagas disease; Amoebiasis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","Downstream TCR signaling; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOJ GTPase cycle; Nephrin family interactions; Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; RND2 GTPase cycle; RHOA GTPase cycle; G alpha (q) signalling events; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; Extra-nuclear estrogen signaling; RHOU GTPase cycle; PIP3 activates AKT signaling; Synthesis of PIPs at the plasma membrane; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Interleukin receptor SHC signaling; Regulation of signaling by CBL; RAF/MAP kinase cascade; PI3K Cascade; GPVI-mediated activation cascade; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; Costimulation by the CD28 family; CD28 dependent PI3K/Akt signaling; VEGFA-VEGFR2 Pathway; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; RND3 GTPase cycle; RND1 GTPase cycle","IL-5 signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase (AMPK) signaling; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL-6 signaling pathway; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Ebola virus pathway in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Modulators of TCR signaling and T cell activation; Orexin receptor pathway; Regulation of actin cytoskeleton; Alzheimer's disease; G13 signaling pathway; Interferon type I signaling pathways; Notch signaling pathway (Netpath); ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway",222.9,234.4,224.6,288,282.3,380.6,0.7171101062151646,-0.4797334452838239,0.04896961608873238,1.3100733007438532,0.22811913575050669,0.641838282446817,1569]
["O00461","Golgi integral membrane protein 4 [OS=Homo sapiens]",38,23,53,23,696,81.8,4.77,156.08,"","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","GOLIM4","ENSG00000173905","","Intra-Golgi traffic","",3643.8,3704.8,3751,4137.1,4307.5,3796.1,0.9067782071286773,-0.1411783761125784,0.06837638068610727,1.1650938911037978,0.26696739659976393,0.573541773621911,1872]
["O00462","Beta-mannosidase [OS=Homo sapiens]",14,11,21,10,879,100.8,5.52,57.12,"protein metabolism;other metabolic processes","plasma membrane;other membranes;other cytoplasmic organelle","other molecular function","MANBA","ENSG00000109323","Other glycan degradation; Lysosome","Neutrophil degranulation; Lysosomal oligosaccharide catabolism","",1395.3,1451.3,1390,1318.6,1323.4,1890.2,0.9347778121000838,-0.09730460419096415,0.6327089592593154,0.19879601581849587,0.7415762962197461,0.12984416045132693,6236]
["O00463","TNF receptor-associated factor 5 [OS=Homo sapiens]",2,1,3,1,557,64.4,7.43,5.82,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton","signal transduction activity or receptor binding;other molecular function","TRAF5","ENSG00000082512","NF-kappa B signaling pathway; Necroptosis; NOD-like receptor signaling pathway; IL-17 signaling pathway; TNF signaling pathway; Shigellosis; Human cytomegalovirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Viral carcinogenesis; Small cell lung cancer","","RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Small cell lung cancer; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling",37.6,29.7,35.6,38.9,36.8,20,1.0752351097178687,0.10465215240794347,0.7280511090955518,0.13783813219923916,0.810683357157128,0.09114874269632178,6564]
["O00469-1","procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 [OS=Homo sapiens]",4,2,2,2,737,84.6,6.71,7.23,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","other molecular function","PLOD2","ENSG00000152952","Lysine degradation; Metabolic pathways","Collagen biosynthesis and modifying enzymes","Clear cell renal cell carcinoma pathways; Type I collagen synthesis in the context of osteogenesis imperfecta",163,170.1,158.9,213.1,233.8,283.6,0.6735112936344969,-0.5702259574642585,0.01987298162280501,1.701736969065988,0.14627555154187494,0.8348282556773963,993]
["O00470","Homeobox protein Meis1 [OS=Homo sapiens]",2,1,1,1,390,43,6.33,2.92,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MEIS1","ENSG00000143995","Signaling pathways regulating pluripotency of stem cells; Transcriptional misregulation in cancer","Activation of anterior HOX genes in hindbrain development during early embryogenesis","Mesodermal commitment pathway",32.2,27.1,31.2,53,61.9,52.2,0.5415918611609813,-0.8847220360906205,1.8332824583189408E-3,2.736770617067921,0.04944450733525143,1.3058819460583537,271]
["O00471","Exocyst complex component 5 [OS=Homo sapiens]",21,14,26,14,708,81.8,6.71,63.68,"cell organization and biogenesis;transport;other biological processes","cytosol;other cell component","other molecular function","EXOC5","ENSG00000070367","Salmonella infection","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium","Ciliary landscape",2088.3,2181.1,2166.7,2119.4,2100,3453.2,0.8388421134947734,-0.25352880211653284,0.4103848513824734,0.3868086787988328,0.5868720169740751,0.2314565978700968,5111]
["O00479","High mobility group nucleosome-binding domain-containing protein 4 [OS=Homo sapiens]",27,3,5,3,90,9.5,10.48,8.92,"cell organization and biogenesis","nucleus;other cell component","nucleic acid binding activity;other molecular function","HMGN4","ENSG00000182952","","","",708,510.8,642.8,575.9,683.9,539,1.0349121636646652,0.04950832673633264,0.7870984790506157,0.10397092681170465,0.8573625608615425,0.06683548509672375,6710]
["O00481-1","Butyrophilin subfamily 3 member A1 [OS=Homo sapiens]",10,5,6,2,513,57.6,8.03,14.04,"cell cycle OR cell proliferation;signal transduction;other biological processes","plasma membrane;other membranes","signal transduction activity or receptor binding","BTN3A1","ENSG00000026950","","Butyrophilin (BTN) family interactions","",218.1,229.2,266.2,230.2,211.3,212.8,1.0904783738346324,0.12496115900121907,0.278618180084011,0.5549905488863325,0.5128230365736682,0.29003247406624244,3971]
["O00483","Cytochrome c oxidase subunit NDUFA4 [OS=Homo sapiens]",56,5,23,5,81,9.4,9.38,59.42,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","NDUFA4","ENSG00000189043","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; Oxidative phosphorylation",4781.5,4585.9,3970.4,4209.6,5351,2755.8,1.0829300769705432,0.11494009348684726,0.6886031116727436,0.1620310191288058,0.7814004258990968,0.107126356400744,6441]
["O00487","26S proteasome non-ATPase regulatory subunit 14 [OS=Homo sapiens]",47,12,47,12,310,34.6,6.52,121.33,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PSMD14","ENSG00000115233","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection","Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; Metalloprotease DUBs","Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease",5910.5,5816.1,5797.2,5230.7,5249.7,4488.4,1.1706883651328097,0.22735708445341501,0.028174712213923744,1.5501405112904876,0.1743683078506085,0.7585324470200294,1181]
["O00499","Myc box-dependent-interacting protein 1 [OS=Homo sapiens]",4,2,6,1,593,64.7,5.06,19.85,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","BIN1","ENSG00000136717","Endocytosis; Fc gamma R-mediated phagocytosis","Clathrin-mediated endocytosis","VEGFA-VEGFR2 signaling pathway; IL-18 signaling pathway",50.8,46.9,49.2,58.4,55.3,50.5,0.8946406820950061,-0.16061973122152487,0.08753616262042875,1.0578124957546744,0.30379953114563807,0.517412900720169,2106]
["O00505","Importin subunit alpha-4 [OS=Homo sapiens]",28,11,49,7,521,57.8,4.94,140.19,"cell organization and biogenesis;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","KPNA3","ENSG00000102753","Nucleocytoplasmic transport; Salmonella infection; Chemical carcinogenesis","ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways","",1008.2,995.6,1007.1,1016,1092.6,662.2,1.0866536740291612,0.11989221417161751,0.5787364814207102,0.23751914044562486,0.7057031936443061,0.15137791717127785,5994]
["O00506","serine/threonine-protein kinase 25 [OS=Homo sapiens]",23,7,35,2,426,48.1,6.74,85.36,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","kinase activity;other molecular function","STK25","ENSG00000115694","","","",70.1,60.2,77.6,65.7,75,246.5,0.5369318181818181,-0.8971891944162248,0.3683117574471328,0.4337844171404473,0.5620022202883286,0.2502619686710375,4790]
["O00507-1","Probable ubiquitin carboxyl-terminal hydrolase FAF-Y [OS=Homo sapiens]",9,21,47,1,2555,290.9,5.86,131.75,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","USP9Y","ENSG00000114374","","","",104.1,130.7,121.3,115,132.6,181.1,{"$f":"AVERAGE(S130:U130)/AVERAGE(V130:X130)","v":0.8306508047585723},{"$f":"LOG(Y130,2)","v":-0.2676859814539099},{"$f":"TTEST(V130:X130,S130:U130,2,2)","v":0.3182167587400944},0.49727695216683826,{"$f":"AA130*7309/AE130","v":0.5390142038543105},0.2683997903340937,4315]
["O00512","B-cell CLL/lymphoma 9 protein [OS=Homo sapiens]",1,1,1,1,1426,149.2,8.91,0,"cell-cell signaling;developmental processes;signal transduction;other biological processes","ER/Golgi;nucleus","other molecular function","BCL9","ENSG00000116128","","Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex","Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; 1q21.1 copy number variation syndrome",14.8,20.4,18.7,15.7,17.8,45,0.6866242038216561,-0.5424073810264838,0.4402997157153438,{"$f":"-LOG10(AA131)","v":0.35625159494769054},0.6091521147384911,{"$f":"-LOG10(AC131)","v":0.21527424375065687},5283]
["O00519","Fatty-acid amide hydrolase 1 [OS=Homo sapiens]",25,10,26,10,579,63,7.66,84.13,"other metabolic processes","other membranes;cytoskeleton;ER/Golgi","other molecular function","FAAH","ENSG00000117480","Retrograde endocannabinoid signaling","Arachidonic acid metabolism","Cannabinoid receptor signaling",2266.8,2179.4,2360.6,2007.5,2099.8,2778.6,0.9885127579546613,-0.016668509085487684,0.9206659370768423,0.03589792463739788,0.9501761273785146,0.022195885175517155,7082]
["O00522","Krev interaction trapped protein 1 [OS=Homo sapiens]",9,6,11,6,736,84.3,8.41,34.25,"developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","KRIT1","ENSG00000001631","Rap1 signaling pathway","","",957.1,972.9,979.1,899.8,920,1279.5,0.938631303842803,-0.09136951908790487,0.6347839885559838,0.1973740361854325,0.742698282752631,0.12918758024748134,6247]
["O00534","von Willebrand factor A domain-containing protein 5A [OS=Homo sapiens]",5,4,4,4,786,86.4,6.58,7.8,"","nucleus","","VWA5A","ENSG00000110002","","","",443.3,452.6,452.2,451.6,417.8,420.5,1.045119776726878,0.06366829291619884,0.16004770752496822,0.7957505421783092,0.3999277587350403,0.39801845071253544,2925]
["O00541-1","Pescadillo homolog [OS=Homo sapiens]",32,18,54,18,588,68,7.33,167.5,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PES1","ENSG00000100029","","Major pathway of rRNA processing in the nucleolus and cytosol","",6533.6,6541.2,6494.2,8828.2,8283.3,8207.2,0.7729069817960637,-0.371633296489382,6.1406575984543441E-4,3.2117851180953796,0.029723222772915763,1.526904103504576,151]
["O00555-1","Voltage-dependent P/Q-type calcium channel subunit alpha-1A [OS=Homo sapiens]",1,1,2,1,2505,282.2,8.84,2.07,"","","","","","","","",1068.9,1069.3,790.7,536.3,571.9,221.5,2.2026772956305933,1.1392581477416572,0.02124625102310976,1.6727176916661444,0.1503280239379567,0.822960051301792,1033]
["O00559","Receptor-binding cancer antigen expressed on SiSo cells [OS=Homo sapiens]",8,1,1,1,213,24.4,6.29,3.29,"other biological processes","other membranes;ER/Golgi;other cell component","enzyme regulator activity","EBAG9","ENSG00000147654","Estrogen signaling pathway","Estrogen-dependent gene expression","",31.4,36,45.1,42.6,51.4,74.3,0.6684491978609626,-0.5811101752255496,0.14435351654424752,0.8405726319622705,0.38186024336659613,0.4180955549948089,2763]
["O00560-1","Syntenin-1 [OS=Homo sapiens]",23,4,13,4,298,32.4,7.53,47.62,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","SDCBP","ENSG00000137575; ENSPPAG00000038846; ENSPTRG00000020277","","Neutrophil degranulation; Ephrin signaling; Neurofascin interactions; Regulation of necroptotic cell death","Ectoderm differentiation; Ectoderm differentiation; VEGFA-VEGFR2 signaling pathway",876.9,921.9,986.6,813.2,835.5,1467.3,0.8939024390243903,-0.16181071137163414,0.6379379411118076,0.19522156758541398,0.7447194396400257,0.12800730948655753,6261]
["O00566","U3 small nucleolar ribonucleoprotein protein Mpp10 [OS=Homo sapiens]",27,15,32,15,681,78.8,4.86,83.9,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","MPHOSPH10","ENSG00000124383","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",2108.6,2192.1,2082.7,3835.5,3701,2119.3,0.6610948859752687,-0.5970707403986004,0.11933845218091396,0.9232195992524982,0.3508627300845938,0.4548627616741512,2486]
["O00567","Nucleolar protein 56 [OS=Homo sapiens]",67,29,161,29,594,66,9.19,489.84,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NOP56","ENSG00000101361","Ribosome biogenesis in eukaryotes; Spinocerebellar ataxia","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; Association of TriC/CCT with target proteins during biosynthesis","",17901,17769.5,18262.2,17149.4,16242.9,16429.3,1.0825164185814986,0.11438890654689587,0.01191613500214006,1.9238645851521645,0.11370108450475418,0.9442353929007955,766]
["O00571","ATP-dependent RNA helicase DDX3X [OS=Homo sapiens]",58,34,224,33,662,73.2,7.18,686.69,"cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function","DDX3X","ENSG00000215301","RIG-I-like receptor signaling pathway; Hepatitis B; Viral carcinogenesis","Neutrophil degranulation","Novel intracellular components of RIG-I-like receptor (RLR) pathway; Hepatitis B infection",27042.3,26575.9,27463.2,33554.5,33132.1,22239.6,0.9117830290735462,-0.1332375381734874,0.5200124472448869,0.2839862607785252,0.6637741838827941,0.17797964258013202,5726]
["O00592","Podocalyxin [OS=Homo sapiens]",13,7,19,7,558,58.6,5.49,54.88,"cell adhesion;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","","PODXL","ENSG00000128567","Salmonella infection","","Primary focal segmental glomerulosclerosis (FSGS); Ectoderm differentiation; Hepatitis C and hepatocellular carcinoma; Nephrotic syndrome; Malignant pleural mesothelioma",2906.8,2934.4,2937.1,2436.9,2684,2327.5,1.1785484130820045,0.23701102365276408,0.013843833574934085,1.8587436302622078,0.12309559561945649,0.9097574859182853,822]
["O00625","Pirin [OS=Homo sapiens]",10,3,9,3,290,32.1,6.92,14.48,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PIR","ENSG00000087842","","Digestion","",1121.9,1046.4,1081.4,1135.8,1048.9,1355.1,0.9180462173004126,-0.12336130966690133,0.3602842006471882,0.4433547823464575,0.5592094335379695,0.25242551090520704,4709]
["O00629","Importin subunit alpha-3 [OS=Homo sapiens]",41,13,91,9,521,57.9,4.96,346.45,"transport","other membranes;cytosol;nucleus","other molecular function","KPNA4","ENSG00000186432","Nucleocytoplasmic transport; Salmonella infection; Chemical carcinogenesis","ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways","Leptin signaling pathway",9959.9,10159.3,10192.2,9700.6,10471,6426,1.1396291394712303,0.18856441588740264,0.375364661938881,0.42554661569798846,0.5650958422474318,0.24787788805803915,4855]
["O00635","E3 ubiquitin-protein ligase TRIM38 [OS=Homo sapiens]",8,4,9,4,465,53.4,7.02,15.62,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","TRIM38","ENSG00000112343","","Interferon gamma signaling","",726.9,686.9,681,762.7,771.6,2036.2,0.5866965411006863,-0.7693136083350415,0.3097921177936151,0.5089296364228004,0.5332714528859003,0.27305166436880746,4246]
["O00743","Serine/threonine-protein phosphatase 6 catalytic subunit [OS=Homo sapiens]",33,9,31,9,305,35.1,5.69,93.67,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport","cytosol;mitochondrion;nucleus","other molecular function","PPP6C","ENSG00000119414","","Telomere Extension By Telomerase; COPII-mediated vesicle transport","",4037.3,3901.9,3797.5,3754.2,3731.2,3826,1.0375992361688209,0.05324932265920863,0.13194074426415878,0.8796210704381825,0.368074389246846,0.43406439987395495,2620]
["O00746","Nucleoside diphosphate kinase, mitochondrial [OS=Homo sapiens]",16,2,4,2,187,20.6,10.29,10.56,"other metabolic processes;transport","other membranes;mitochondrion","kinase activity;other molecular function","NME4","ENSG00000103202","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors","Interconversion of nucleotide di- and triphosphates","Pyrimidine metabolism",431.2,424.2,446.7,361.1,418.5,419,1.086350742532955,0.11948997129828885,0.16500798627938865,0.7824950357064938,0.40744708503920657,0.3899287848814595,2960]
["O00750","Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [OS=Homo sapiens]",2,3,3,3,1634,184.7,7.3,8.8,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","PIK3C2B","ENSG00000133056","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Salmonella infection","Synthesis of PIPs at the plasma membrane","Glioblastoma signaling pathways; S1P receptor signal transduction; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; EGF/EGFR signaling pathway; Osteoblast differentiation and related diseases; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)",192.3,164.3,169.3,200.9,207.5,222.7,0.8333069244176837,-0.2630801265722303,0.031198889141858806,1.5058608690632749,0.18374913838666077,0.7357746886780319,1241]
["O00754","Lysosomal alpha-mannosidase [OS=Homo sapiens]",11,10,16,10,1011,113.7,7.28,49.54,"protein metabolism;other metabolic processes","non-structural extracellular;other membranes;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MAN2B1","ENSG00000104774","Other glycan degradation; Lysosome","Neutrophil degranulation; Lysosomal oligosaccharide catabolism","",1987,2105.1,2003.8,1786.6,1800,4479.4,0.755752541532358,-0.4040141693639017,0.5043012147330105,0.2973099857349612,0.652262887716081,0.18557733114888653,5651]
["O00762","Ubiquitin-conjugating enzyme E2 C [OS=Homo sapiens]",6,1,1,1,179,19.6,7.37,0,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","UBE2C","ENSG00000175063","Ubiquitin mediated proteolysis","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Gastric cancer network 1; Gastric cancer network 2",24.4,31.9,20.7,49.4,62.7,137.8,0.3081232492997199,-1.69842055050444,0.10608892612076364,0.9743299466890715,0.3361092158719815,0.473519579326192,2307]
["O00763","Acetyl-CoA carboxylase 2 [OS=Homo sapiens]",5,9,16,5,2458,276.4,6.49,54.84,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus","other molecular function","ACACB","ENSG00000076555","Fatty acid biosynthesis; Pyruvate metabolism; Propanoate metabolism; Metabolic pathways; AMPK signaling pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Glucagon signaling pathway; Insulin resistance; Alcoholic liver disease","ChREBP activates metabolic gene expression; Biotin transport and metabolism; Carnitine metabolism; Activation of gene expression by SREBF (SREBP)","AMP-activated protein kinase (AMPK) signaling; Leptin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; IL-18 signaling pathway; 7q11.23 copy number variation syndrome",520.1,501.9,521.5,550.4,556.6,808,0.8060052219321149,-0.3111389091971948,0.2192643953989846,0.6590318842236654,0.46519694222675717,0.33236314858333704,3445]
["O00764-1","Pyridoxal kinase [OS=Homo sapiens]",57,17,137,17,312,35.1,6.13,367.38,"other metabolic processes","non-structural extracellular;nucleus;other cell component","kinase activity;other molecular function","HEL-S-1a; PDXK","ENSG00000160209","Vitamin B6 metabolism; Metabolic pathways; Biosynthesis of cofactors","Neutrophil degranulation; Vitamins B6 activation to pyridoxal phosphate","",11821.9,11409,12025.2,10624.9,10519.4,8501,1.1892644027889752,0.25006949741002155,0.05893388662370896,1.2296349167265044,0.24956418153689963,0.6028177462217221,1726]
["O00767","acyl-CoA desaturase [OS=Homo sapiens]",13,5,23,5,359,41.5,9,75.05,"other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","SCD","ENSG00000099194","Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; AMPK signaling pathway; Alcoholic liver disease","Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis","Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Adipogenesis; Liver X receptor pathway; Nuclear receptors meta-pathway; Fatty acid biosynthesis; Angiopoietin-like protein 8 regulatory pathway; PPAR signaling pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways",3252,3162.6,3372,4986.8,6148,2671.5,0.7088503074683298,-0.49644709855713237,0.26068457497002945,0.5838846658151376,0.5008789585846334,0.30026721219654096,3804]
["O14492","SH2B adapter protein 2 [OS=Homo sapiens]",13,4,8,4,632,67.7,6.27,21.53,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;other molecular function","SH2B2","ENSG00000160999","Neurotrophin signaling pathway; Insulin signaling pathway","Regulation of KIT signaling; Factors involved in megakaryocyte development and platelet production","Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; Insulin signaling",94.6,101.7,111.4,120.6,118,143.7,0.8048652890400211,-0.3131807565011037,0.05910564682969891,1.2283710255514553,0.2498572427289007,0.602308056941405,1729]
["O14494","Phospholipid phosphatase 1 [OS=Homo sapiens]",4,1,2,1,284,32.1,7.97,6.94,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","PLPP1","ENSG00000067113","Glycerolipid metabolism; Glycerophospholipid metabolism; Ether lipid metabolism; Sphingolipid metabolism; Metabolic pathways; Phospholipase D signaling pathway; Fc gamma R-mediated phagocytosis; Fat digestion and absorption; Choline metabolism in cancer","Sphingolipid de novo biosynthesis","Androgen receptor signaling pathway; Androgen receptor signaling pathway; Sphingolipid pathway; Triacylglyceride synthesis; Androgen receptor signaling pathway",332.6,354.9,326.3,358.4,327.4,393,0.9397478680014832,-0.08965435764612684,0.35717816308565764,0.4471151005709975,0.5585398361131947,0.2529458467432326,4674]
["O14497","AT-rich interactive domain-containing protein 1A [OS=Homo sapiens]",21,40,81,38,2285,241.9,6.7,259.41,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ARID1A","ENSG00000117713","Thermogenesis; Hepatocellular carcinoma","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines","Pathways affected in adenoid cystic carcinoma; Tumor suppressor activity of SMARCB1; Thermogenesis",7062.5,7025,6886.1,8249.5,8664.5,9550.9,0.792506300798416,-0.3355056894845378,0.009149947850282423,2.038581381168428,0.1002653205962732,0.998849253201004,667]
["O14523","Phospholipid transfer protein C2CD2L [OS=Homo sapiens]",21,11,23,11,706,76.1,7.69,62.31,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","transporter activity;other molecular function","C2CD2L","ENSG00000172375","","","",1164.4,1222.3,1217.3,958.5,1110.6,1685.9,0.9597869507323568,-0.05921389658809569,0.8319629621739146,0.07989600746111895,0.8860290383985345,0.05255204446781735,6863]
["O14524-1","Nuclear envelope integral membrane protein 1 [OS=Homo sapiens]",8,4,9,4,444,50.6,6.93,22.32,"cell organization and biogenesis","other membranes;nucleus","","NEMP1","ENSG00000166881","","","",1361.6,1255.9,1376.7,1438.4,1364.9,1897.1,0.8497574674495787,-0.234876960032579,0.2401799970240332,0.6194631648924069,0.4830697848785522,0.31599012598044945,3634]
["O14526-1","F-BAR domain only protein 1 [OS=Homo sapiens]",4,4,4,4,889,96.8,6.96,10.43,"cell organization and biogenesis;transport","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","FCHO1","ENSG00000130475","","Cargo recognition for clathrin-mediated endocytosis","",148.4,146.8,161.4,185.4,176.8,409.7,0.5915273999222698,-0.7574830982302545,0.24083531112269838,0.6182798367603614,0.48345654737594135,0.3156425538103321,3641]
["O14530","Thioredoxin domain-containing protein 9 [OS=Homo sapiens]",33,6,14,6,226,26.5,5.88,40.52,"","cytosol;cytoskeleton;nucleus;other cell component","","TXNDC9","ENSG00000115514","","","",1110.2,1308.7,1119.1,1868.3,1816.3,1616,0.6674716069878881,-0.5832216263703036,0.004274072528496892,2.3691581123875034,0.07264929328089254,1.1387686060831168,430]
["O14531","dihydropyrimidinase-related protein 4 [OS=Homo sapiens]",11,2,16,2,572,61.8,7.09,35.54,"cell organization and biogenesis;developmental processes;other biological processes","cytosol","cytoskeletal activity;other molecular function","DPYSL4","ENSG00000151640","","CRMPs in Sema3A signaling","",820.4,813.4,891.6,791.6,747,1400.1,0.8593595807670059,-0.21866617209051845,0.5514709801437108,0.258477336342652,0.6861936319152847,0.16355331664546044,5874]
["O14545","TRAF-type zinc finger domain-containing protein 1 [OS=Homo sapiens]",2,1,1,1,582,64.8,5.29,1.98,"other biological processes","","other molecular function","TRAFD1","ENSG00000135148","","","Regulation of toll-like receptor signaling pathway",85.9,89.3,70.4,121.2,127,28.6,0.8872832369942196,-0.1725333822665453,0.76431650482427,0.11672676206004565,0.839932240830039,0.0757557480102233,6651]
["O14548","Cytochrome c oxidase subunit 7A-related protein, mitochondrial [OS=Homo sapiens]",11,1,1,1,114,12.6,9.42,3.72,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion;nucleus","transporter activity","COX7A2L","ENSG00000115944","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease",96.2,115.5,98.4,131,132,109,0.8336021505376344,-0.26256909538277134,0.09982780267033511,1.0007484881241109,0.32573277219530333,0.4871385445743007,2240]
["O14561","Acyl carrier protein, mitochondrial [OS=Homo sapiens]",13,2,3,2,156,17.4,4.93,8.5,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;nucleus","other molecular function","NDUFAB1","ENSG00000004779","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Glyoxylate metabolism and glycine degradation; Mitochondrial Fatty Acid Beta-Oxidation; Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",198.9,268.7,197.7,237.4,356.7,597,0.5585593149189825,-0.8402176023691498,0.1809670513914089,0.7424004897798328,0.42461899795178415,0.37200057889104815,3115]
["O14562","Ubiquitin domain-containing protein UBFD1 [OS=Homo sapiens]",19,4,13,4,309,33.4,5.77,35.8,"","","","UBFD1","ENSG00000103353","","","",1499.6,1833.2,1336.7,1890.3,1816.8,1556.1,0.8871979024167808,-0.17267214031705147,0.3281994835705388,0.48386210665477736,0.5439478515684961,0.26444273423864295,4410]
["O14576-1","cytoplasmic dynein 1 intermediate chain 1 [OS=Homo sapiens]",6,3,4,3,645,72.9,5.12,8.9,"transport;other biological processes","cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","DNCI1; DYNC1I1","ENSG00000158560; ENSGGOG00000000228; ENSPTRG00000019422","Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection","Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Intraflagellar transport proteins binding to dynein",192.1,205.7,182.6,227.8,215.2,327.7,0.7530816141170363,-0.4091218715552289,0.15470675243198292,0.8104907303862768,0.39412744981713604,0.4043633167483022,2869]
["O14578-4","Isoform 4 of Citron Rho-interacting kinase [OS=Homo sapiens]",5,9,11,9,2069,236.5,6.67,18.9,"","","","CIT","","","","",724.5,673.2,689.7,653.9,668.8,616.2,1.0765898189695189,0.10646868734195142,0.08529911544197923,1.0690554724744372,0.2998803438025138,0.5230519999219334,2079]
["O14579-1","coatomer subunit epsilon [OS=Homo sapiens]",36,11,48,11,308,34.5,5.12,138.59,"transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","COPE","ENSG00000105669; ENSPTRG00000010723","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport","",6079.9,5849.8,6041.5,5904.8,5629.1,4351.1,1.1313314447592067,0.1780216558163432,0.2240422029677962,0.6496701656406206,0.4705530061757535,0.3273914477032287,3480]
["O14593","DNA-binding protein RFXANK [OS=Homo sapiens]",4,1,1,1,260,28.1,4.55,0,"signal transduction;other biological processes","non-structural extracellular;cytosol;nucleus","nucleic acid binding activity;other molecular function","RFXANK","ENSG00000064490","Antigen processing and presentation; Tuberculosis; Primary immunodeficiency","","",55.6,77.7,67.1,97.1,92.3,180.7,0.5414752769521751,-0.8850326271050121,0.1266915039678149,0.8972525082705687,0.3610090458092628,0.4424819158344308,2565]
["O14617-5","Isoform 5 of AP-3 complex subunit delta-1 [OS=Homo sapiens]",36,40,125,40,1215,136.6,7.64,411.02,"","","","AP3D1","","","","",12450.4,12737.4,12515.7,12059.2,12303.9,11535.3,1.0502835780981885,0.07077891025324054,0.06832325291913942,1.1654314647546284,0.26733118607387046,0.5729503747647301,1868]
["O14618","copper chaperone for superoxide dismutase [OS=Homo sapiens]",16,5,19,5,274,29,5.58,36.89,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","CCS","ENSG00000173992","Amyotrophic lateral sclerosis; Pathways of neurodegeneration","Detoxification of Reactive Oxygen Species","Amyotrophic lateral sclerosis (ALS); Copper homeostasis",1840.5,1851.9,1845.2,1892.3,1917,3252.6,0.7841515739390249,-0.3507955453501716,0.3213999595675785,0.49295418220733095,0.5421445429216319,0.2658849093577328,4333]
["O14628-1","Zinc finger protein 195 [OS=Homo sapiens]",7,3,4,1,629,72.3,8.09,5.49,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF195","ENSG00000005801","Herpes simplex virus 1 infection","Generic Transcription Pathway","",25,33,22.6,25.6,36.6,9.4,1.1256983240223462,0.17082025126371067,0.742012230990353,0.12958893595030016,0.8214734014402439,0.08540649406061987,6602]
["O14639-1","Actin-binding LIM protein 1 [OS=Homo sapiens]",7,5,6,5,778,87.6,8.59,12.99,"cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ABLIM1","ENSG00000099204","Axon guidance","DCC mediated attractive signaling","Male infertility",743.3,706.8,708.1,767.6,728.4,1006,0.862589928057554,-0.21325322419664616,0.26073179704742183,0.5838060020493174,0.5008380301234182,0.3003027012719361,3805]
["O14641","Segment polarity protein dishevelled homolog DVL-2 [OS=Homo sapiens]",6,4,6,2,736,78.9,6.02,11.66,"cell-cell signaling;cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","DVL2","ENSG00000004975","mTOR signaling pathway; Wnt signaling pathway; Notch signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer","RHO GTPases Activate Formins; Asymmetric localization of PCP proteins; Degradation of DVL; Cargo recognition for clathrin-mediated endocytosis; WNT mediated activation of DVL; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Negative regulation of TCF-dependent signaling by DVL-interacting proteins; WNT5:FZD7-mediated leishmania damping; Signaling by Hippo; WNT5A-dependent internalization of FZD4","Alzheimer's disease and miRNA effects; Neural crest differentiation; Notch signaling; Wnt signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Type 2 papillary renal cell carcinoma; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Malignant pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)",170.8,176.7,174.2,252.2,264.8,468.8,0.5292148508825321,-0.9180745476434871,0.09231978802599866,1.0347052013638722,0.31268087612698064,0.504898679826791,2158]
["O14646","Chromodomain-helicase-DNA-binding protein 1 [OS=Homo sapiens]",13,18,26,15,1710,196.6,7.14,58.47,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CHD1","ENSG00000153922","","Estrogen-dependent gene expression","",2021.4,1965.4,2000.8,2481.4,2504.8,2489.5,0.8009417178324438,-0.32023082909892214,9.7190486565300918E-6,5.012376243658071,0.011839421105096407,1.9266695321577416,6]
["O14647","Chromodomain-helicase-DNA-binding protein 2 [OS=Homo sapiens]",11,17,26,14,1828,211.2,8.1,66.08,"cell organization and biogenesis;stress response;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","CHD2","ENSG00000173575","","","Prion disease pathway; Male infertility",1343.6,1364.6,1381.2,1564.8,1646.3,1463,0.8749063990928733,-0.19279941484262464,0.022741795062462416,1.6431752584277899,0.15578236186648342,0.8074817159682868,1067]
["O14653-1","Golgi SNAP receptor complex member 2 [OS=Homo sapiens]",21,4,7,4,212,24.8,8.06,14.57,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","other molecular function","GOSR2","ENSG00000108433","SNARE interactions in vesicular transport","COPI-mediated anterograde transport; Intra-Golgi traffic; COPII-mediated vesicle transport; XBP1(S) activates chaperone genes; Cargo concentration in the ER","",546.5,569,560.8,641.8,730.6,596,0.8516053647632594,-0.23174305668361464,0.07191354962775254,1.14318927409331,0.2734735349787946,0.5630846955418638,1922]
["O14656","Torsin-1A [OS=Homo sapiens]",20,6,14,6,332,37.8,6.99,37.88,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","TOR1A","ENSG00000136827","","Cargo recognition for clathrin-mediated endocytosis","",1334.8,1333.6,1364.2,1348,1279,1088.1,1.0854620333234637,0.11830926506509819,0.24822535100835427,0.6051538665084828,0.4910092261218028,0.3089103473553544,3695]
["O14662-2","Isoform A of Syntaxin-16 [OS=Homo sapiens]",24,7,16,7,304,34.8,6.2,46.86,"","","","STX16","","","","",947.4,962.3,963.6,834.2,976.3,1727.1,0.8122173224785164,-0.3000622983720426,0.4689176332669698,0.3289034356626135,0.6275991542846149,0.20231765031418392,5461]
["O14672","Disintegrin and metalloproteinase domain-containing protein 10 [OS=Homo sapiens]",38,25,56,25,748,84.1,7.77,170.99,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ADAM10","ENSG00000137845","Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection","Amyloid fiber formation; Collagen degradation; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; NOTCH3 Activation and Transmission of Signal to the Nucleus; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant; Signaling by EGFR; EPH-ephrin mediated repulsion of cells; NOTCH4 Activation and Transmission of Signal to the Nucleus","Alzheimer's disease and miRNA effects; Copper homeostasis; Canonical and non-canonical Notch signaling; VEGFA-VEGFR2 signaling pathway; 3q29 copy number variation syndrome; Interactions of natural killer cells in pancreatic cancer; Alzheimer's disease; Hypertrophy model",4205.2,3915.6,4158.1,4325.1,4485.8,5928.8,0.8330495193253594,-0.2635258379979507,0.18828988415746836,0.72517301175499,0.43263463165889227,0.3638787189783804,3181]
["O14681","Etoposide-induced protein 2.4 homolog [OS=Homo sapiens]",2,1,3,1,340,38.9,9.72,5.03,"other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus","other molecular function","EI24","ENSG00000149547","p53 signaling pathway","","miRNA regulation of p53 pathway in prostate cancer; Genotoxicity pathway",409.2,406.9,454,380.7,391.1,705.4,0.8598023287300298,-0.2179230770961361,0.5562059030559288,0.25476440624673885,0.6891522199416483,0.1616848405319135,5899]
["O14683","Tumor protein p53-inducible protein 11 [OS=Homo sapiens]",8,1,2,1,189,21,9.55,8.88,"other biological processes","other membranes","","TP53I11","ENSG00000175274","","","",135.6,141.7,149.9,133.4,139.1,273.4,0.782560908591317,-0.3537250500588638,0.4375978044286062,0.35892486566670295,0.606907467280585,0.21687751899527655,5270]
["O14686-1","Histone-lysine N-methyltransferase 2D [OS=Homo sapiens]",4,13,15,12,5537,593,5.58,42.08,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","KMT2D","ENSG00000167548","Lysine degradation; Metabolic pathways; Cushing syndrome","Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","Histone modifications; 16p11.2 proximal deletion syndrome",551.6,534.3,580.3,707.1,728.6,1326.8,0.6031493212669683,-0.7294128815135166,0.1469963240940779,0.8326935254260996,0.38495024464479227,0.4145954000307578,2791]
["O14717-1","tRNA (cytosine(38)-C(5))-methyltransferase [OS=Homo sapiens]",2,1,2,1,391,44.6,6.09,5.15,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DNMT2; TRDMT1","ENSG00000107614","","tRNA modification in the nucleus and cytosol","",426.3,380.8,356.1,326.9,433.1,151.6,1.27599824484423,0.3516263446542973,0.37768905328872027,0.42286560231888226,0.5662624185614885,0.24698226046946492,4875]
["O14730","serine/threonine-protein kinase RIO3 [OS=Homo sapiens]",12,6,7,6,519,59.1,5.76,17.24,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;other cell component","kinase activity;other molecular function","RIOK3","ENSG00000101782","","Major pathway of rRNA processing in the nucleolus and cytosol","",696.8,652.2,684.6,776.7,803.3,958,0.8012608353033885,-0.3196561337235093,0.044322716910927096,1.353373625913685,0.2187405387589238,0.6600707225509206,1481]
["O14732-1","inositol monophosphatase 2 [OS=Homo sapiens]",7,2,2,2,288,31.3,6.61,5.48,"other metabolic processes;signal transduction","cytosol;other cell component","other molecular function","IMPA2","ENSG00000141401","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of IP2, IP, and Ins in the cytosol","",144,132.8,162.9,166.1,172.4,249.5,0.7477891156462586,-0.41929662251107935,0.15463676043319827,0.8106872571476543,0.3940865000021779,0.4044084422594439,2868]
["O14733","dual specificity mitogen-activated protein kinase kinase 7 [OS=Homo sapiens]",18,6,10,6,419,47.5,9.16,26.35,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","MAP2K7","ENSG00000076984","MAPK signaling pathway; ErbB signaling pathway; Protein processing in endoplasmic reticulum; Osteoclast differentiation; Tight junction; Toll-like receptor signaling pathway; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; TNF signaling pathway; Neurotrophin signaling pathway; GnRH signaling pathway; Relaxin signaling pathway; Alcoholic liver disease; Alzheimer disease; Huntington disease; Pathways of neurodegeneration; Salmonella infection; Yersinia infection; Hepatitis B; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Chemical carcinogenesis; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; Uptake and function of anthrax toxins","Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; MAPK signaling pathway; ERK pathway in Huntington's disease; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; MAPK cascade; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; IL-18 signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Malignant pleural mesothelioma; Alzheimer's disease; ErbB signaling pathway; Toll-like receptor signaling pathway",1182.7,1187.9,1139.4,1208.7,1302.9,933.7,1.018779206455171,0.02684141924953312,0.8564563711138733,0.06729475560226444,0.9052551867637454,0.04322897816362091,6915]
["O14734","Acyl-coenzyme A thioesterase 8 [OS=Homo sapiens]",20,5,8,5,319,35.9,7.56,23.55,"cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle","other molecular function","ACOT8","ENSG00000101473","Primary bile acid biosynthesis; Metabolic pathways; Peroxisome","Peroxisomal protein import; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of pristanoyl-CoA; Beta-oxidation of very long chain fatty acids","",643.3,643.8,696.1,571,491.8,526,1.2482376636455184,0.31989264855834804,0.010373744045709723,1.9840644716795468,0.10634178854150403,0.9732960396474394,713]
["O14735","CDP-diacylglycerol--inositol 3-phosphatidyltransferase [OS=Homo sapiens]",25,5,18,5,213,23.5,8.03,34.86,"other metabolic processes","plasma membrane;other membranes;ER/Golgi","other molecular function","CDIPT","ENSG00000103502","Inositol phosphate metabolism; Glycerophospholipid metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of PI","Glycerolipids and glycerophospholipids; 16p11.2 proximal deletion syndrome",1636.8,1534.8,1638.7,1314.8,1364.5,1431.9,1.1700476746448722,0.2265673149133494,0.008471219731207192,2.07205405314099,0.09644259348192114,1.0157311193258705,642]
["O14744","Protein arginine N-methyltransferase 5 [OS=Homo sapiens]",37,21,49,21,637,72.6,6.29,162.74,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","PRMT5","ENSG00000100462","","snRNP Assembly; RMTs methylate histone arginines; Regulation of TP53 Activity through Methylation","Transcription co-factors SKI and SKIL protein partners; Nitric oxide metabolism in cystic fibrosis",6659.4,6797.3,6856.2,6239.4,6233.2,6015.1,1.0987250983086054,0.13583046825487463,2.9389763383783412E-3,2.5318039104068313,0.06033982600339128,1.2193959464957336,356]
["O14745","Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [OS=Homo sapiens]",69,21,108,21,358,38.8,5.77,328.28,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;transporter activity;cytoskeletal activity;other molecular function","SLC9A3R1","ENSG00000109062","Tight junction; Parathyroid hormone synthesis, secretion and action; Pathogenic Escherichia coli infection; Human papillomavirus infection","","",13738.3,14877.6,10719.2,14842,14667.6,15476.2,0.8743892517194315,-0.19365242785098863,0.21064549710627364,0.6764478201962822,0.4559099610156216,0.34112091894772073,3377]
["O14757","Serine/threonine-protein kinase Chk1 [OS=Homo sapiens]",4,2,2,2,476,54.4,8.25,5.21,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","CHEK1","ENSG00000149554","Cell cycle; p53 signaling pathway; Cellular senescence; Human T-cell leukemia virus 1 infection; Human immunodeficiency virus 1 infection; Viral carcinogenesis","Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Transcriptional Regulation by E2F6; Signaling by SCF-KIT; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex","miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; ATR signaling; ATM signaling in development and disease ; DNA repair pathways, full network; DNA damage response",186.8,197.4,204.8,468.5,406.6,199.1,0.5483150251349842,-0.8669230874377108,0.11864003094251714,0.9257687487112767,0.35035959036721526,0.4554859900968913,2475]
["O14772","fucose-1-phosphate guanylyltransferase [OS=Homo sapiens]",3,1,1,1,594,66.6,6.48,3.55,"","","other molecular function","FPGT","ENSG00000254685","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars","","",40.4,39.3,31.8,39.5,25.4,45,1.0145586897179253,0.02085232385843583,0.9378985657860375,0.027844128253616547,0.95969489252837,0.017866816494185932,7143]
["O14773","Tripeptidyl-peptidase 1 [OS=Homo sapiens]",32,10,45,10,563,61.2,6.48,142.15,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","TPP1","ENSG00000166340","Lysosome","XBP1(S) activates chaperone genes","VEGFA-VEGFR2 signaling pathway",5478.6,5526.2,5611.1,5407.2,5617.3,6027.4,{"$f":"AVERAGE(S194:U194)/AVERAGE(V194:X194)","v":0.9744310018238437},{"$f":"LOG(Y194,2)","v":-0.03736806112380083},{"$f":"TTEST(V194:X194,S194:U194,2,2)","v":0.4786696828556591},0.3199640782323737,{"$f":"AA194*7309/AE194","v":0.6331155830604438},0.1985169969288933,5526]
["O14776-1","Transcription elongation regulator 1 [OS=Homo sapiens]",25,33,92,33,1098,123.8,8.65,229.28,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","TCERG1","ENSG00000113649; ENSGGOG00000003329; ENSPTRG00000017375","Spliceosome","","",12591.4,12275,12422.1,13546.6,13575.3,13963.2,0.9075918033545007,-0.13988451508955327,1.4658224903855604E-3,{"$f":"-LOG10(AA195)","v":2.833918619131245},0.04445517254036539,{"$f":"-LOG10(AC195)","v":1.3520776998221407},241]
["O14777","Kinetochore protein NDC80 homolog [OS=Homo sapiens]",29,18,37,18,642,73.9,5.6,94.67,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","NDC80","ENSG00000080986","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",4265,4283.5,4152.1,5123.2,5579.2,3890,0.8703571722266387,-0.200320527426415,0.2808477635327196,0.5515290301793865,0.5154988206078974,0.28777232398680425,3982]
["O14782","Kinesin-like protein KIF3C [OS=Homo sapiens]",3,3,5,1,793,89.4,8.22,10.83,"transport;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF3C","ENSG00000084731","","Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins","",283.1,289.4,273.8,329.1,273.9,497.8,0.7688045058139534,-0.3793113033953704,0.27720246378962665,0.5572029140115864,0.5116345474339347,0.2910401380531257,3960]
["O14787-2","Isoform 2 of Transportin-2 [OS=Homo sapiens]",30,19,68,11,887,100.3,4.98,205.82,"","","","TNPO2","","","","",1693.7,1762,1800,1506.4,1518.2,1350.3,1.2013303161215112,0.26463288702130583,0.009277183879731924,2.0325838353221686,0.10120438354770243,0.9948006761390222,670]
["O14795","Protein unc-13 homolog B [OS=Homo sapiens]",14,16,28,16,1591,180.6,5.99,85.29,"cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","UNC13B","ENSG00000198722","Synaptic vesicle cycle","Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle","Synaptic vesicle pathway; 16p11.2 proximal deletion syndrome; Monoamine transport",1764.7,1777.2,1809.7,1847.4,1900.7,2540.4,0.851013755267552,-0.2327456439445098,0.2340677408580617,0.6306584365071989,0.4797535383992072,0.31898181346256177,3566]
["O14802","DNA-directed RNA polymerase III subunit RPC1 [OS=Homo sapiens]",22,26,44,25,1390,155.5,8.48,120,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR3A","ENSG00000148606","RNA polymerase; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","Pyrimidine metabolism; Cytosolic DNA-sensing pathway",4599,4462.6,4563,4610.6,4636.6,4556,0.987060971368958,-0.018788891284910694,0.27591813872833104,0.5592197482678821,0.5113300395449725,0.29129869265308284,3944]
["O14818-1","Proteasome subunit alpha type-7 [OS=Homo sapiens]",63,16,110,16,248,27.9,8.46,348.28,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","HEL-S-276; PSMA7","ENSG00000101182","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease",12309.9,12222.3,12689.5,12164.8,11610.6,8384.4,1.1573983669052665,0.2108855135725163,0.228347111377253,0.6414044779078857,0.4741446128000972,0.32408917950204374,3520]
["O14828","Secretory carrier-associated membrane protein 3 [OS=Homo sapiens]",56,13,79,13,347,38.3,7.64,296.69,"transport","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SCAMP3","ENSG00000116521; ENSG00000263290","","","",5341.2,5069.7,5279.5,5118.4,5874.1,5729.6,0.9383032035450094,-0.09187390395109464,0.2342675154069358,0.6302879284649264,0.47975939201717394,0.31897651453661385,3569]
["O14832","Phytanoyl-CoA dioxygenase, peroxisomal [OS=Homo sapiens]",5,2,2,2,338,38.5,8.47,4.08,"other metabolic processes","cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","PHYH","ENSG00000107537","Peroxisome","TYSND1 cleaves peroxisomal proteins; Alpha-oxidation of phytanate","",173.6,167.9,191.9,169.8,191.3,148.7,1.0462926637897214,0.0652864515287243,0.610800943917172,0.21410030046679127,0.7255556800082252,0.13932925367084703,6153]
["O14836","Tumor necrosis factor receptor superfamily member 13B [OS=Homo sapiens]",7,1,1,1,293,31.8,7.94,4.71,"developmental processes;signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","TNFRSF13B","ENSG00000240505","Cytokine-cytokine receptor interaction; Intestinal immune network for IgA production; Primary immunodeficiency","TNFs bind their physiological receptors","",35.8,52.4,53.4,60.8,62.7,176.9,0.47137150466045274,-1.0850635474312742,0.24429481380180842,0.6120857526793025,0.4874558542389893,0.3120647094598745,3663]
["O14867","Transcription regulator protein BACH1 [OS=Homo sapiens]",9,6,6,6,736,81.9,5.05,18.29,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","BACH1","ENSG00000156273","","Heme signaling; Regulation of HMOX1 expression and activity; Regulation of BACH1 activity","Integrated cancer pathway; Ferroptosis",191.1,194.4,217.8,314.9,280.4,374.4,0.6221511807775602,-0.6846629015794461,0.013117431065655098,1.8821512094154453,0.11969451143429852,0.92192576361571,801]
["O14874","[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial [OS=Homo sapiens]",24,7,11,7,412,46.3,8.82,34.8,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","kinase activity;other molecular function","BCKDK","ENSG00000103507","","Branched-chain amino acid catabolism","Thiamine metabolic pathways",1175.8,1169.2,1290.1,1556.8,1344.9,1617.2,0.8044214299940251,-0.3139765789647776,0.032199296559701655,1.492153615992894,0.1861903944263128,0.7300427280552874,1264]
["O14880","Microsomal glutathione S-transferase 3 [OS=Homo sapiens]",38,4,23,4,152,16.5,9.38,79.97,"other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","MGST3","ENSG00000143198","Glutathione metabolism; Metabolism of xenobiotics by cytochrome P450; Drug metabolism; Drug metabolism; Metabolic pathways; Platinum drug resistance; Pathways in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Chemical carcinogenesis; Hepatocellular carcinoma; Fluid shear stress and atherosclerosis","Aflatoxin activation and detoxification; Glutathione conjugation","Nuclear receptors meta-pathway; NRF2 pathway; Metapathway biotransformation Phase I and II",3540.5,3542.8,3477.8,3059.4,3020.6,1386.6,1.4144456646934347,0.500236757304719,0.13485964625501964,0.8701179838384864,0.3719581715011089,0.4295058958913213,2650]
["O14893","Gem-associated protein 2 [OS=Homo sapiens]",14,3,6,3,280,31.6,5.58,17.9,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","","GEMIN2","ENSG00000092208","","snRNP Assembly","",335.6,368.6,447.2,461.3,546.8,1025.1,0.566299429470785,-0.8203630185319077,0.175013152280402,0.7569293127527342,0.4165324422069223,0.38035116731183016,3071]
["O14920-1","Inhibitor of nuclear factor kappa-B kinase subunit beta [OS=Homo sapiens]",26,12,24,12,756,86.5,5.78,76.67,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","IKBKB","ENSG00000104365","Antifolate resistance; MAPK signaling pathway; Ras signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; FoxO signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; TNF signaling pathway; Neurotrophin signaling pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; Alcoholic liver disease; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Chagas disease; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Pancreatic cancer; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; CLEC7A (Dectin-1) signaling; IKK complex recruitment mediated by RIP1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation","Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNAs involvement in the immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Nonalcoholic fatty liver disease; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; Insulin signaling; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; T-cell receptor (TCR) signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway",1847.4,1775.9,1883.3,1795.6,1692.1,1936.7,1.015153749723472,0.0216982467851987,0.7418350355851908,0.12969265954609036,0.8214016474916164,0.08544443041370259,6601]
["O14929","histone acetyltransferase type B catalytic subunit [OS=Homo sapiens]",44,14,93,14,419,49.5,5.69,261.91,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","mitochondrion;nucleus;other cell component","other molecular function","HAT1","ENSG00000128708","Neutrophil extracellular trap formation; Alcoholism","HATs acetylate histones","Ethanol effects on histone modifications",11186,10983.3,11023.8,10441.6,9834.6,9981.5,1.097013322228722,0.13358104606617976,0.007136730273795545,2.1465007166963153,0.08962605080957325,1.0475657394622309,582]
["O14933","Ubiquitin/ISG15-conjugating enzyme E2 L6 [OS=Homo sapiens]",15,2,3,2,153,17.8,7.88,9.18,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","UBE2L6","ENSG00000156587","Ubiquitin mediated proteolysis; Parkinson disease; Pathways of neurodegeneration","Antigen processing: Ubiquitination & Proteasome degradation; Amyloid fiber formation; ISG15 antiviral mechanism; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling","Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway; 7q11.23 copy number variation syndrome",416,614.8,353.2,619.4,783.5,462.4,0.7419718007827157,-0.43056373775019924,0.2578233005815732,0.5886778361807306,0.49721121476272256,0.3034590842648299,3790]
["O14936","peripheral plasma membrane protein CASK [OS=Homo sapiens]",6,5,8,5,926,105.1,6.43,25.47,"cell adhesion;protein metabolism;other metabolic processes;transport;other biological processes","extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","CASK","ENSG00000147044","","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Assembly and cell surface presentation of NMDA receptors; Nephrin family interactions; Neurexins and neuroligins; Dopamine Neurotransmitter Release Cycle; Syndecan interactions","Parkin-ubiquitin proteasomal system pathway; Splicing factor NOVA regulated synaptic proteins",811.5,848,885.6,609.2,608.6,881.8,1.2121832730043816,0.27760783995390226,0.18723495068765136,0.7276130793479432,0.43129538436055587,0.3652251895643825,3173]
["O14949","Cytochrome b-c1 complex subunit 8 [OS=Homo sapiens]",30,4,17,4,82,9.9,10.08,40.67,"other metabolic processes;transport;developmental processes","other membranes;mitochondrion","","UQCRQ","ENSG00000164405","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly",3660.3,5026,3382.7,3560.8,4564.9,2446,1.1416328499673656,0.1910987534189179,0.5643078708551209,0.2484838922337544,0.6948325855930052,0.15811982262075205,5936]
["O14950","Myosin regulatory light chain 12B [OS=Homo sapiens]",66,11,109,11,172,19.8,4.84,318.93,"other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYL12B","ENSG00000118680","Axon guidance; Focal adhesion; Tight junction; Platelet activation; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Shigellosis; Salmonella infection","RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs","Thyroid stimulating hormone (TSH) signaling pathway; Focal adhesion",8397.5,10169.3,6109.8,8901,9224.1,9556.3,0.8914505769216875,-0.16577327954578094,0.44740033732218265,0.34930369279838036,0.612942655199219,0.21258015467489605,5335]
["O14964","Hepatocyte growth factor-regulated tyrosine kinase substrate [OS=Homo sapiens]",26,19,36,19,777,86.1,6.16,92.11,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","HGS","ENSG00000185359","Endocytosis; Phagosome","Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; Endosomal Sorting Complex Required For Transport (ESCRT); Ub-specific processing proteases; RHOU GTPase cycle; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Inhibition of membrane repair; Prevention of phagosomal-lysosomal fusion; RHOBTB3 ATPase cycle","TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway",4115,4317.9,3938.2,4465.3,4814.4,6327.4,0.792658469542708,-0.33522870491164003,0.13740245941213355,0.8620054936261113,0.3755701480341377,0.425308934668104,2674]
["O14965","Aurora kinase A [OS=Homo sapiens]",15,5,6,5,403,45.8,9.39,16.59,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","AURKA","ENSG00000087586","Oocyte meiosis; Progesterone-mediated oocyte maturation","APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; SUMOylation of DNA replication proteins; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Interaction between PHLDA1 and AURKA","Integrated breast cancer pathway; Gastric cancer network 1; EGF/EGFR signaling pathway",464,507.9,469.4,536.9,485.6,846.2,0.7712848504307808,-0.37466432111771836,0.2776316888266091,0.5565309651008559,0.5117805835141704,0.2909161948705056,3965]
["O14967","calmegin [OS=Homo sapiens]",22,10,25,9,610,70,4.69,63.37,"cell organization and biogenesis;stress response;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","CLGN","ENSG00000153132","","","",1619.4,1727.9,1612.4,1482,1599.7,1672.4,1.0432468816390064,0.061080608259429556,0.36352343678364385,0.43946758442614225,0.5600743675066722,0.2517543028983755,4744]
["O14972","Down syndrome critical region protein 3 [OS=Homo sapiens]",16,3,8,3,297,33,7.68,19.29,"transport","other cytoplasmic organelle","","VPS26C","ENSG00000157538","","","",539.5,561.1,563.7,534.5,480.3,399,1.1771820625265244,0.23533746429445343,0.10584430606389407,0.9753325000587757,0.33577084766536536,0.4739570129259772,2304]
["O14974","Protein phosphatase 1 regulatory subunit 12A [OS=Homo sapiens]",51,50,148,3,1030,115.2,5.4,403.41,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP1R12A","ENSG00000058272","cGMP-PKG signaling pathway; cAMP signaling pathway; Vascular smooth muscle contraction; Focal adhesion; Platelet activation; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Proteoglycans in cancer","Regulation of PLK1 Activity at G2/M Transition; RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs","Focal adhesion; Hippo-Merlin signaling dysregulation; Regulation of actin cytoskeleton",19458.1,19040,19661,22099,22183.2,14814.9,0.9841278167625822,-0.02308239249948282,0.9045712175590749,0.043557235133253214,0.9396689922028537,0.027025104034703873,7036]
["O14974-4","Isoform 4 of Protein phosphatase 1 regulatory subunit 12A [OS=Homo sapiens]",53,48,152,1,971,109,5.41,415.41,"","","","PPP1R12A","","","","",563.6,521.5,573.2,615.7,604.8,512.4,0.9569507761555773,-0.06348337793222998,0.5321561807266613,0.2739608893714438,0.6723473681817056,0.17240629077523925,5785]
["O14975","very long-chain acyl-CoA synthetase [OS=Homo sapiens]",23,11,29,11,620,70.3,8.51,72.21,"other metabolic processes;transport","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","transporter activity;other molecular function","SLC27A2","ENSG00000140284","PPAR signaling pathway; Peroxisome; Insulin resistance","Peroxisomal protein import; Neutrophil degranulation; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Alpha-oxidation of phytanate; Synthesis of bile acids and bile salts via 24-hydroxycholesterol","PPAR signaling pathway",2457.1,2555.2,2556.1,2091.2,2281.9,3344.1,0.9807183952728967,-0.028089156267625186,0.9052104978773217,0.04325041810246627,0.9400658608959,0.02684171871766615,7038]
["O14976","Cyclin-G-associated kinase [OS=Homo sapiens]",23,22,59,22,1311,143.1,5.73,183.19,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;ER/Golgi;other cell component","kinase activity;other molecular function","GAK","ENSG00000178950","","Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis","",5300.4,5144.3,5203.4,5640.1,5590.7,6262.5,0.8945196160815857,-0.16081497514419232,0.04960172594106047,1.3045032115413036,0.22873123968656847,0.6406745162111009,1585]
["O14979-1","Heterogeneous nuclear ribonucleoprotein D-like [OS=Homo sapiens]",30,15,127,13,420,46.4,9.57,302.04,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","HNRNPDL; HNRPDL","ENSG00000152795; ENSPPAG00000043177; ENSPTRG00000016217","","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","",11850.6,11946.5,11474.8,12641.1,14005.7,8899.1,0.9922916567030232,-0.011163871618021957,0.9553564359985285,0.019834566314970464,0.9717089049141726,0.012463817299628206,7186]
["O14980","Exportin-1 [OS=Homo sapiens]",47,39,166,39,1071,123.3,6.06,503.63,"transport;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","XPO1","ENSG00000082898","Ribosome biogenesis in eukaryotes; Nucleocytoplasmic transport; Influenza A; Human T-cell leukemia virus 1 infection","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; MAPK6/MAPK4 signaling; Deactivation of the beta-catenin transactivating complex; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Heme signaling; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Downregulation of TGF-beta receptor signaling; HuR (ELAVL1) binds and stabilizes mRNA; Cyclin A/B1/B2 associated events during G2/M transition","eIF5A regulation in response to inhibition of the nuclear export system; 22q11.2 copy number variation syndrome",17255.2,17563.9,17901.4,16609.7,15939.8,14510.8,1.1202754763569294,0.16385353541331724,0.04331050950864552,1.3634067071615992,0.21667112525577692,0.6641989612119231,1461]
["O14981","TATA-binding protein-associated factor 172 [OS=Homo sapiens]",15,20,44,20,1849,206.8,6.52,146.79,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","BTAF1","ENSG00000095564","","","",3134.6,3014.2,3145.3,3293.8,3497.7,3862.9,0.8723250488061269,-0.19706227763792675,0.057523875193215314,1.2401518646568113,0.24572881577277075,0.6095439123139385,1711]
["O14986","Phosphatidylinositol 4-phosphate 5-kinase type-1 beta [OS=Homo sapiens]",5,2,3,1,540,61,6.86,6.4,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","kinase activity;other molecular function","PIP5K1B","ENSG00000107242","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Phospholipase D signaling pathway; Endocytosis; Focal adhesion; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Yersinia infection; Choline metabolism in cancer","Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; WNT mediated activation of DVL","B cell receptor signaling pathway; Wnt signaling pathway; Regulation of actin cytoskeleton",36.4,33.8,36.2,40,37.5,56.3,0.795216741405082,-0.33057996514027166,0.19977076882606523,0.6994680589843032,0.44543152817257803,0.35121904633481044,3278]
["O15014","zinc finger protein 609 [OS=Homo sapiens]",1,1,1,1,1411,151.1,8.03,2.25,"developmental processes;other biological processes","nucleus","other molecular function","ZNF609","ENSG00000180357","","","",96.2,107.6,111.8,191,173.3,185.5,0.5740269188795927,-0.8008097014994945,3.6900978922239149E-4,3.432962112570276,0.022856716520563217,1.6409861579924285,118]
["O15015","Zinc finger protein 646 [OS=Homo sapiens]",1,1,1,1,1829,200.6,7.33,3.44,"","","","","","","","",94.5,78.5,80.4,117.5,116.3,257.6,0.5156695156695157,-0.9554813332213553,0.1679021962395002,0.7749436230492194,0.40920211814421703,0.3880621269247736,2999]
["O15020","Spectrin beta chain, non-erythrocytic 2 [OS=Homo sapiens]",13,30,70,16,2390,271.2,6.11,202.36,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SPTBN2","ENSG00000173898","Spinocerebellar ataxia; Pathways of neurodegeneration","MHC class II antigen presentation; COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins","",868.6,909.8,952.7,907,941.9,2017.4,0.7063859503918476,-0.5014714459858912,0.35873710805155906,0.4452236972340395,0.5590638641255533,0.2525385780651498,4690]
["O15027-5","Isoform 5 of Protein transport protein Sec16A [OS=Homo sapiens]",22,34,83,34,2201,235.6,5.67,232.92,"","","","","","","","",6846.4,6684.1,6796.5,7680.2,7940.7,10692,0.7725108216882214,-0.3723729517906379,0.10742262166924013,0.9689042527928532,0.3355350178549043,0.4742621483190231,2340]
["O15031","Plexin-B2 [OS=Homo sapiens]",6,10,18,9,1838,205,6.24,46.43,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","PLXNB2","ENSG00000196576","Axon guidance","","",761.3,732.8,822.4,748.7,678.7,1592.7,0.7670275818681499,-0.3826496377472409,0.47094136944555687,0.32703315765076935,0.628695976123758,0.20155931927895232,5475]
["O15037","protein KHNYN [OS=Homo sapiens]",7,4,4,4,678,74.5,7.02,12.78,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KHNYN","ENSG00000100441","","","",274.8,304.3,289.4,320.6,326.6,443.7,0.7961316344302868,-0.3289211055267855,0.1446073590410133,0.8398096053154775,0.3821168428166183,0.41780381920479637,2766]
["O15042-2","Isoform 2 of U2 snRNP-associated SURP motif-containing protein [OS=Homo sapiens]",31,24,78,1,1028,118.2,8.47,207.63,"","","","U2SURP","","","","",6933.7,6727.8,6886.7,7732.4,7754.8,5273.8,0.9897500120418092,-0.014863915079418087,0.9356644582891669,0.028879867116175142,0.9590199867670061,0.018172341680044925,7131]
["O15047","Histone-lysine N-methyltransferase SETD1A [OS=Homo sapiens]",6,8,12,8,1707,185.9,5.14,36.58,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SETD1A","ENSG00000099381","Lysine degradation; Metabolic pathways","PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","Histone modifications",649.6,641.1,682.5,645.7,674.9,1386.3,0.7289519376408439,-0.45610439914591855,0.3702145055123263,0.4315465689960154,0.5620892855815524,0.25019469305105363,4814]
["O15050","TPR and ankyrin repeat-containing protein 1 [OS=Homo sapiens]",1,1,1,1,2925,336,6.76,0,"","","","TRANK1","ENSG00000168016","","","",29.9,28.4,31.4,30.9,24.4,35.5,0.9878854625550659,-0.017584312371653987,0.9177318631450813,0.03728418956856024,0.9479511288478518,0.023214051922272758,7076]
["O15056","Synaptojanin-2 [OS=Homo sapiens]",3,4,4,4,1496,165.4,7.34,11.76,"cell organization and biogenesis;other metabolic processes;transport;developmental processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity;other molecular function","SYNJ2","ENSG00000078269","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane","",304.9,308.6,362.7,394.9,354,683.2,0.6816563089169753,-0.5528835791007978,0.222314784912078,0.6530316538452577,0.46840552404796143,0.3293779918033446,3469]
["O15061-1","Synemin [OS=Homo sapiens]",4,5,5,5,1565,172.7,5.16,13.83,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SYNM","ENSG00000182253","","","",164.7,154.5,155.6,159.9,165.8,252.1,0.8217376254759431,-0.28325026892270905,0.31589446615279604,0.5004579820098715,0.5370720291022997,0.26996746524290544,4299]
["O15062","zinc finger and BTB domain-containing protein 5 [OS=Homo sapiens]",2,1,1,1,677,74.2,6.19,3.91,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB5","ENSG00000168795","","","",41,49.1,44.7,54.3,63.8,123.1,0.558872305140962,-0.8394094107182261,0.1767628174547966,0.7526090847555946,0.41892329208077445,0.377865492250541,3084]
["O15066","Kinesin-like protein KIF3B [OS=Homo sapiens]",18,11,14,9,747,85.1,7.69,41.08,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF3B","ENSG00000101350","","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins","",1277.9,1211.6,1139.4,1330.2,1336.7,1117.4,0.9589356023571071,-0.060494161061629796,0.5636859791058756,0.24896276750849575,0.6946519678443508,0.15823272965785753,5931]
["O15067","Phosphoribosylformylglycinamidine synthase [OS=Homo sapiens]",33,35,110,35,1338,144.6,5.76,331.34,"other metabolic processes;other biological processes","cytosol","other molecular function","PFAS","ENSG00000178921","Purine metabolism; Metabolic pathways","Purine ribonucleoside monophosphate biosynthesis","",13553.1,13169.6,13651.5,12803.2,13171.3,14186.5,1.0053086327531684,0.007638481092691281,0.8792400425653564,0.05589254138850846,0.9218713916382427,0.035329662241042586,6971]
["O15078-1","Centrosomal protein of 290 kDa [OS=Homo sapiens]",1,2,4,2,2479,290.2,5.95,10.65,"cell organization and biogenesis;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","CEP290","ENSG00000198707","","Neutrophil degranulation; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","Clear cell renal cell carcinoma pathways; Ciliary landscape; Joubert syndrome; Ciliopathies",1226.2,1368.5,1158,1358.8,1425.2,1782.5,0.8217891163911091,-0.2831598710166784,0.13561152465673298,0.867703401308592,0.3730465313195564,0.42823699383489666,2657]
["O15084","serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A [OS=Homo sapiens]",14,11,22,9,1053,112.9,6.25,80.85,"","cytosol;nucleus","","ANKRD28","ENSG00000206560","","Telomere Extension By Telomerase; COPII-mediated vesicle transport","",1353.3,1472.8,1477.3,1468.1,1427.2,1690.3,0.9384595254710395,-0.09163357003514391,0.36094631965609525,0.442557382057312,0.5591684294969055,0.2524573567229157,4718]
["O15085-1","Rho guanine nucleotide exchange factor 11 [OS=Homo sapiens]",1,2,2,2,1522,167.6,5.5,5.16,"cell organization and biogenesis;signal transduction;other biological processes","other membranes;cytosol;other cell component","signal transduction activity or receptor binding;enzyme regulator activity","ARHGEF11","ENSG00000132694","Vascular smooth muscle contraction; Parathyroid hormone synthesis, secretion and action; Pathogenic Escherichia coli infection; Human cytomegalovirus infection; Pathways in cancer","RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOB GTPase cycle; Sema4D induced cell migration and growth-cone collapse","",147.5,155.7,161.7,161.6,166.3,260.6,0.7899745114698387,-0.3401219894068422,0.2737641228504217,0.5626234673379501,0.5090160198203337,0.29326854927406637,3931]
["O15091","Mitochondrial ribonuclease P protein 3 [OS=Homo sapiens]",19,10,14,10,583,67.3,8.78,42.78,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus","other molecular function","PRORP","ENSG00000100890","","tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion","",1317.9,1342,1330.2,1204.9,1384.1,807.2,1.1748719156704555,0.23250348300356333,0.3104528654786418,0.5080043272632583,0.5339058808902102,0.27253529542959676,4250]
["O15111","Inhibitor of nuclear factor kappa-B kinase subunit alpha [OS=Homo sapiens]",8,4,5,4,745,84.6,6.73,16.69,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","CHUK","ENSG00000213341","Antifolate resistance; MAPK signaling pathway; Ras signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; FoxO signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; TNF signaling pathway; Adipocytokine signaling pathway; Alcoholic liver disease; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Chagas disease; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Chemical carcinogenesis; Pancreatic cancer; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Constitutive Signaling by AKT1 E17K in Cancer; IKK complex recruitment mediated by RIP1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; AKT phosphorylates targets in the cytosol","Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Canonical and non-canonical Notch signaling; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Chemokine signaling pathway; IL-4 signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNAs involvement in the immune response in sepsis; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - interferon induction; Neuroinflammation; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; T-cell receptor (TCR) signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway",340.2,352.9,361.2,363.1,333.5,503.5,0.8785101241563203,-0.18686918260253926,0.4093312205128776,0.3879251295805558,0.5857090623979293,0.23231805628796046,5108]
["O15116","U6 snRNA-associated Sm-like protein LSm1 [OS=Homo sapiens]",35,4,6,4,133,15.2,5.22,15.68,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","LSM1","ENSG00000175324","RNA degradation","mRNA decay by 5' to 3' exoribonuclease","",505.1,500.9,493.1,558.2,546.3,1157.9,0.6626149222065063,-0.593757401352355,0.27619352186965457,0.558786512032754,0.5110628990747609,0.2915256457752412,3950]
["O15118","Niemann-Pick C1 protein [OS=Homo sapiens]",4,5,16,5,1278,142.1,5.36,47.77,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","NPC1","ENSG00000141458","Lysosome; Cholesterol metabolism","LDL clearance","Irinotecan pathway; Irinotecan pathway; Irinotecan pathway; Ebola virus pathway in host; Irinotecan pathway; Irinotecan pathway",1324,1345.3,1339.3,1239.9,1277.1,1189.6,1.0814762855447042,0.1130020304389062,0.018272816581481735,1.7381945051096312,0.14103064033162618,0.8506865222289316,947]
["O15121","Sphingolipid delta(4)-desaturase DES1 [OS=Homo sapiens]",5,1,4,1,323,37.8,7.46,17.04,"cell organization and biogenesis;other metabolic processes;developmental processes","plasma membrane;other membranes;mitochondrion;ER/Golgi","other molecular function","DEGS1","ENSG00000143753","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway","Neutrophil degranulation; Sphingolipid de novo biosynthesis","Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway; Sphingolipid metabolism in senescence",234.3,268.2,262.9,240.3,276.3,244.9,1.0051214707813525,0.007369864293840987,0.9369987943249559,0.028260967936507213,0.9593114144447545,0.018040388011128533,7139]
["O15126-1","Secretory carrier-associated membrane protein 1 [OS=Homo sapiens]",12,4,6,4,338,37.9,7.42,21.87,"transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","SCAMP1","ENSG00000085365","","Neutrophil degranulation","",779.3,866.2,707.9,827.5,964.6,1194.7,0.7879335743940002,-0.3438540844084205,0.144152184448203,0.8411787720297631,0.3820189688658142,0.4179150719856211,2758]
["O15127","Secretory carrier-associated membrane protein 2 [OS=Homo sapiens]",16,5,25,5,329,36.6,6.1,97.67,"transport","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","SCAMP2","ENSG00000140497","","","Serotonin transporter activity; Monoamine transport",2097.3,2013.8,2087,2190,2172.4,2220.4,0.9415598225679044,-0.08687533464132886,0.012600608529334692,1.8996084807117637,0.11747174456748374,0.9300665815122292,784]
["O15143","Actin-related protein 2/3 complex subunit 1B [OS=Homo sapiens]",51,17,75,16,372,40.9,8.35,254.53,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","ARPC1B","ENSG00000130429","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling","Pathogenic Escherichia coli infection; Microglia pathogen phagocytosis pathway",13506.2,13797.1,12936.4,12658,12872.7,9442.8,1.150576865340901,0.2023573673446094,0.19771109909240558,0.7039689496075051,0.44422699762262297,0.3523950510053857,3253]
["O15144","Actin-related protein 2/3 complex subunit 2 [OS=Homo sapiens]",67,19,142,19,300,34.3,7.36,398.24,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity","ARPC2","ENSG00000163466","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling","Pathogenic Escherichia coli infection",22616.3,22459.3,22116,19720,17620.2,12857.7,1.3385340821030365,0.4206538737228355,0.049667738804011194,1.3039256114421465,0.2284590956063674,0.641191546765553,1589]
["O15145","Actin-related protein 2/3 complex subunit 3 [OS=Homo sapiens]",31,6,26,6,178,20.5,8.59,47.95,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity","ARPC3","ENSG00000111229","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection","Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling","Pathogenic Escherichia coli infection",2355,3658.9,2124.1,2440.7,3381.1,1933.8,1.0493063077002425,0.06943588296197778,0.8515717768995603,0.06977874054030986,0.901526378528228,0.04502156136349008,6904]
["O15155","BET1 homolog [OS=Homo sapiens]",51,3,4,3,118,13.3,9.06,15.06,"cell organization and biogenesis;transport","other membranes;ER/Golgi","other molecular function","BET1","ENSG00000105829","SNARE interactions in vesicular transport","COPI-mediated anterograde transport; COPII-mediated vesicle transport","",212.4,197,222.6,209,215.8,338.3,0.8282007600576595,-0.27194756818667914,0.3636257312064218,0.4393453924314576,0.559995884826746,0.25181516442880486,4746]
["O15156","Zinc finger and BTB domain-containing protein 7B [OS=Homo sapiens]",5,1,1,1,539,58,5.86,3.39,"RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZBTB7B","ENSG00000160685","","","Ectoderm differentiation; Ectoderm differentiation",15.3,18.1,21.3,14.9,15,26.6,0.9681415929203541,-0.04671003450999337,0.8946216870381262,0.04836057805378689,0.9327803010786968,0.03022063413647256,7010]
["O15160","DNA-directed RNA polymerases I and III subunit RPAC1 [OS=Homo sapiens]",37,9,25,9,346,39.2,5.5,78.2,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR1C","ENSG00000171453","RNA polymerase; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","Pyrimidine metabolism; Cytosolic DNA-sensing pathway",1493.1,1474.2,1499.6,1537.9,1599.4,1806.7,0.9034991909385112,-0.14640478569513032,0.12333637115610249,0.9089088336790083,0.3565923800553612,0.4478279414053828,2528]
["O15162","phospholipid scramblase 1 [OS=Homo sapiens]",3,1,1,1,318,35,4.94,2.06,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","extracellular matrix;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;transporter activity;nucleic acid binding activity;other molecular function","PLSCR1","ENSG00000188313","","","EGF/EGFR signaling pathway; Complement system in neuronal development and plasticity",27.2,27.6,36.1,35.3,25.5,18.6,1.1448362720403022,0.1951412870511493,0.5345494455376105,0.2720121165900112,0.6739730718361903,0.1713574550768099,5797]
["O15164","Transcription intermediary factor 1-alpha [OS=Homo sapiens]",14,10,14,9,1050,116.8,7.11,36.53,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;kinase activity;other molecular function","TRIM24","ENSG00000122779","","Signaling by BRAF and RAF1 fusions; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease","",1061.4,1089.2,1126.9,1138,1105.9,2018.8,{"$f":"AVERAGE(S258:U258)/AVERAGE(V258:X258)","v":0.7688788795833629},{"$f":"LOG(Y258,2)","v":-0.3791717445376734},{"$f":"TTEST(V258:X258,S258:U258,2,2)","v":0.3347219700682625},0.4753157810205597,{"$f":"AA258*7309/AE258","v":0.5475565978578627},0.26157098358015823,4468]
["O15173","Membrane-associated progesterone receptor component 2 [OS=Homo sapiens]",49,13,55,11,223,23.8,4.88,196.01,"transport;developmental processes;signal transduction","other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","PGRMC2","ENSG00000164040","","RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle","Ciliary landscape",5624.3,5986.5,5883,5516.9,5889.3,6640.6,0.9693574484119065,-0.04489934053705288,0.6239594610987096,{"$f":"-LOG10(AA259)","v":0.20484362569105222},0.7358050502049804,{"$f":"-LOG10(AC259)","v":0.13323723571034343},6198]
["O15182","Centrin-3 [OS=Homo sapiens]",15,3,3,3,167,19.5,4.74,7.09,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","CETN3","ENSG00000153140","","","Breast cancer pathway",261,372.6,220.3,397.5,471.3,230.9,0.7764844957715742,-0.3649709765809974,0.3867662588621357,0.4125514203934619,0.5708551264182855,0.24347409452155053,4952]
["O15211","Ral guanine nucleotide dissociation stimulator-like 2 [OS=Homo sapiens]",3,2,2,2,777,83.5,6.18,5.85,"signal transduction;other biological processes","cytosol","enzyme regulator activity","RGL2","ENSG00000206282; ENSG00000224841; ENSG00000228736; ENSG00000237441; ENSG00000237825","Ras signaling pathway","RAF/MAP kinase cascade","Ras signaling",134.1,147.4,137.9,153.2,163.6,520.7,0.5007761194029849,-0.9977623290232673,0.3131065879855532,0.504307794421819,0.535822067802952,0.27097940396467,4271]
["O15213","WD repeat-containing protein 46 [OS=Homo sapiens]",21,11,15,11,610,68,9.67,46.35,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","WDR46","ENSG00000204221; ENSG00000206284; ENSG00000226916; ENSG00000227057; ENSG00000236222","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",824.8,812.7,809.7,1603.9,1703,2132.8,0.44987775061124685,-1.1523950768847362,3.5616182790116544E-3,2.4483526284444634,0.0657370404073136,1.1821898524860026,396]
["O15226","NF-kappa-B-repressing factor [OS=Homo sapiens]",32,22,55,22,690,77.6,8.79,152.72,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","NKRF","ENSG00000186416","","","Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Network map of SARS-CoV-2 signaling pathway",5241.2,5237.5,5111.6,5878.1,5708.8,5687.8,0.9024932415613586,-0.14801196665754873,1.6001502104364628E-3,2.7958392470305347,0.04568553862531292,1.3402212504584115,256]
["O15228","Dihydroxyacetone phosphate acyltransferase [OS=Homo sapiens]",23,14,32,14,680,77.1,6.57,82.48,"cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;other cytoplasmic organelle","other molecular function","GNPAT","ENSG00000116906","Glycerophospholipid metabolism; Peroxisome","Peroxisomal protein import; Plasmalogen biosynthesis; Synthesis of PA","Triacylglyceride synthesis",3497.4,3476.8,3560.2,3477.7,2936.5,2952.2,1.1247010591048858,0.1695415900128755,0.09604988415822305,1.017503154586513,0.31881407961510094,0.49646250733827285,2202]
["O15229","Kynurenine 3-monooxygenase [OS=Homo sapiens]",8,3,4,3,486,55.8,9.03,13.58,"other metabolic processes;stress response;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion","other molecular function","KMO","ENSG00000117009","Tryptophan metabolism; Metabolic pathways; Biosynthesis of cofactors","Tryptophan catabolism","Selenium micronutrient network; NAD biosynthesis II (from tryptophan)",231.5,229,247.5,243,241.8,478.7,0.7348209652309289,-0.4445353062127237,0.34157510305630384,0.466513791962283,0.5497847232412519,0.25980733197927663,4541]
["O15230","Laminin subunit alpha-5 [OS=Homo sapiens]",0,1,1,1,3695,399.5,7.02,3.56,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;other cell component","signal transduction activity or receptor binding;extracellular structural activity","LAMA5","ENSG00000130702","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Toxoplasmosis; Amoebiasis; Human papillomavirus infection; Pathways in cancer; Small cell lung cancer","Degradation of the extracellular matrix; ECM proteoglycans; Non-integrin membrane-ECM interactions; Interleukin-4 and Interleukin-13 signaling; Laminin interactions; MET activates PTK2 signaling","Alpha 6 beta 4 signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Complement system; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Inflammatory response pathway; Small cell lung cancer; Malignant pleural mesothelioma",17,15.8,14.2,14.3,20.3,64.6,0.4737903225806452,-1.0776793638218756,0.3348062751632572,0.47520641076469133,0.5474494552949098,0.26165597201265484,4470]
["O15234","Protein CASC3 [OS=Homo sapiens]",17,9,11,9,703,76.2,6.48,19.86,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","CASC3","ENSG00000108349","Nucleocytoplasmic transport; mRNA surveillance pathway","Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","",1419,1359.3,1355.4,2220.8,2193.9,2484.5,0.5991564239332097,-0.738995393089249,6.3051587257001386E-4,3.2003039760491814,0.030120526226236802,1.5211374449828075,153]
["O15235","28S ribosomal protein S12, mitochondrial [OS=Homo sapiens]",30,3,14,3,138,15.2,10.29,40.07,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPS12","ENSG00000128626; ENSG00000283018","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1458.9,1505.5,1413.8,1434.4,1475.1,1304.3,1.0390146660971094,0.05521601858883933,0.39759980138240675,0.4005538412227784,0.5785500593876192,0.2376590574983547,5023]
["O15243","Leptin receptor gene-related protein [OS=Homo sapiens]",17,2,4,2,131,14.2,6.51,9.3,"transport;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","signal transduction activity or receptor binding","LEPROT","ENSG00000213625","","","",358.3,384.4,385.4,398.2,378.5,603.9,0.8171085035491815,-0.2914004288314817,0.3109244001622344,0.507345194843252,0.5340884702199228,0.27238679737988564,4255]
["O15247","Chloride intracellular channel protein 2 [OS=Homo sapiens]",57,13,57,11,247,28.3,5.59,218.71,"other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","transporter activity;other molecular function","CLIC2","ENSG00000155962","","Stimuli-sensing channels; Ion homeostasis","",3248.2,3674.1,3177.9,3318.9,3663.7,3649.4,0.9499811888638073,-0.07402914881387357,0.40725605843996865,0.3901324463012788,0.5853755223476363,0.23256544167606927,5085]
["O15254","Peroxisomal acyl-coenzyme A oxidase 3 [OS=Homo sapiens]",24,12,20,12,700,77.6,7.25,66.46,"other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle","other molecular function","ACOX3","ENSG00000087008","Fatty acid degradation; beta-Alanine metabolism; alpha-Linolenic acid metabolism; Propanoate metabolism; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Carbon metabolism; Fatty acid metabolism; PPAR signaling pathway; cAMP signaling pathway; Peroxisome; Alcoholic liver disease","Peroxisomal protein import; Beta-oxidation of pristanoyl-CoA","PPAR signaling pathway; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Omega-3 / omega-6 fatty acid synthesis",1130.4,1160.6,1214.1,1130.5,1084.8,1461.4,0.9533277123507491,-0.0689558600681274,0.6614300286804239,0.1795160921647297,0.7606029074300217,0.1188420188160987,6356]
["O15258","Protein RER1 [OS=Homo sapiens]",24,4,18,4,196,22.9,9.54,56.74,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding","RER1","ENSG00000157916","","","",2287.9,2428.9,2504.2,2359.5,2446.1,1686.1,1.1123434539488886,0.15360231216597664,0.3832090863859584,0.4165642017842619,0.5697467885262347,0.24431811411470544,4916]
["O15260-1","surfeit locus protein 4 [OS=Homo sapiens]",21,5,34,5,269,30.4,7.78,61.06,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","","SURF4","ENSG00000148248; ENSG00000280951; ENSGGOG00000014456; ENSNLEG00000013096; ENSPTRG00000021519","","COPI-dependent Golgi-to-ER retrograde traffic; Neutrophil degranulation","",2683.7,2708.6,2660,2093.7,2134.9,1342.3,1.4454217451399234,0.5314905036924178,0.032711102728976926,1.48530481506067,0.1876651882622389,0.7266162811760287,1274]
["O15264","Mitogen-activated protein kinase 13 [OS=Homo sapiens]",28,7,19,6,365,42.1,8.38,64.93,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","MAPK13","ENSG00000156711","Endocrine resistance; MAPK signaling pathway; Rap1 signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Oocyte meiosis; Cellular senescence; Adrenergic signaling in cardiomyocytes; VEGF signaling pathway; Osteoclast differentiation; Signaling pathways regulating pluripotency of stem cells; Platelet activation; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; TNF signaling pathway; Leukocyte transendothelial migration; Thermogenesis; Neurotrophin signaling pathway; Retrograde endocannabinoid signaling; Dopaminergic synapse; Inflammatory mediator regulation of TRP channels; GnRH signaling pathway; Progesterone-mediated oocyte maturation; Prolactin signaling pathway; Relaxin signaling pathway; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Alcoholic liver disease; Amyotrophic lateral sclerosis; Prion disease; Pathways of neurodegeneration; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Yersinia infection; Leishmaniasis; Chagas disease; Toxoplasmosis; Tuberculosis; Hepatitis B; Human cytomegalovirus infection; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Proteoglycans in cancer; Chemical carcinogenesis; PD-L1 expression and PD-1 checkpoint pathway in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","VEGFA-VEGFR2 Pathway; NOD1/2 Signaling Pathway; p38MAPK events; DSCAM interactions","Regulation of toll-like receptor signaling pathway; Parkinson's disease pathway; Retinoblastoma gene in cancer; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Angiopoietin-like protein 8 regulatory pathway; Oxidative damage response; Epithelial to mesenchymal transition in colorectal cancer; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Regulatory circuits of the STAT3 signaling pathway; Hepatitis B infection; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - apoptosis; Host-pathogen interaction of human coronaviruses - MAPK signaling; Toll-like receptor signaling pathway",1583.9,1526.2,1570.3,1598.6,1390.7,1556.8,1.0295418050636809,0.04200241251853153,0.5338373779542909,0.27259102127353596,0.6737726464285809,0.17148662432293696,5791]
["O15269","serine palmitoyltransferase 1 [OS=Homo sapiens]",18,8,16,8,473,52.7,6.01,50.1,"other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","SPTLC1","ENSG00000090054","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway","Sphingolipid de novo biosynthesis","Sphingolipid pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway",1122.5,1137.6,1165.8,1210.2,1157.6,1512.7,0.8828501481767812,-0.17975951412447852,0.24525875522796473,0.6103754802606576,0.4877812903295767,0.3117748617968983,3675]
["O15270","Serine palmitoyltransferase 2 [OS=Homo sapiens]",11,5,12,5,562,62.9,7.78,29.59,"other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","SPTLC2","ENSG00000100596","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway","Sphingolipid de novo biosynthesis","Sphingolipid pathway; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway",589.9,597.9,598.4,586.7,582.6,993.7,0.8257975034674063,-0.27614003789014885,0.40919977961967235,0.3880646088552489,0.5856356352536097,0.23237250482681604,5107]
["O15287","Fanconi anemia group G protein [OS=Homo sapiens]",2,1,1,1,622,68.5,5.47,2.22,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus","nucleic acid binding activity","FANCG","ENSG00000221829","Fanconi anemia pathway","Fanconi Anemia Pathway","Retinoblastoma gene in cancer; DNA repair pathways, full network",24.8,28.8,27.5,26.2,31.8,37,0.8536842105263157,-0.2282255990010373,0.2369039416094286,0.6254277134225116,0.48164976612609556,0.3172686462574401,3595]
["O15294","UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit [OS=Homo sapiens]",12,12,22,12,1046,116.9,6.7,62.76,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component","other molecular function","OGT","ENSG00000147162","Other types of O-glycan biosynthesis; Insulin resistance","UCH proteinases; Regulation of necroptotic cell death; HATs acetylate histones","Ectoderm differentiation; Ectoderm differentiation",2593,2596.2,2647.8,3685.8,3531.2,4889.2,0.6473542482364408,-0.6273726882139639,0.02958274796195911,1.5289614865499248,0.17899031858771453,0.7471704589510649,1208]
["O15297","protein phosphatase 1D [OS=Homo sapiens]",7,3,3,3,605,66.6,8.94,10.35,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus","kinase activity;other molecular function","PPM1D","ENSG00000170836","p53 signaling pathway","Transcriptional regulation by RUNX2","ATM signaling in development and disease ; Genotoxicity pathway",167.8,157.8,149.7,139.4,134.1,768.7,0.45605450009595083,-1.1327218531292134,0.420538345819285,0.3761943979197039,0.5941841812474684,0.22607891444481348,5173]
["O15305","Phosphomannomutase 2 [OS=Homo sapiens]",44,12,65,11,246,28.1,6.77,167.72,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","PMM2","ENSG00000140650","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars","Defective PMM2 causes PMM2-CDG (CDG-1a); Synthesis of GDP-mannose","Nephrotic syndrome",8003.8,7836.7,8017.2,8350,8145.3,7184.9,1.0074957137186342,0.010773700976543527,0.8786937333936267,0.05616247085863746,0.9215629928790382,0.03547497349456239,6969]
["O15315-1","Isoform 2 of DNA repair protein RAD51 homolog 2 [OS=Homo sapiens]",3,1,1,1,350,38.2,6.1,2.84,"","","","RAD51B","","","","",24.9,17.9,28.6,28.4,18.4,95.2,0.5028169014084507,-0.9918949503629448,0.3878390603239042,0.4113484540791933,0.5711697948634729,0.24323476739254368,4963]
["O15320","Endoplasmic reticulum export factor CTAGE5 [OS=Homo sapiens]",31,22,47,22,804,90.9,5.22,160.23,"","","","","","","","",5237.3,5346,5262.7,5428.3,5866.5,4146.1,1.0262355173597395,0.03736186226547765,0.806923902460336,0.0931674198006758,0.8693701065864674,0.06079529716536031,6784]
["O15321-1","Transmembrane 9 superfamily member 1 [OS=Homo sapiens]",5,2,3,2,606,68.8,7.17,10.15,"other metabolic processes;other biological processes","other membranes;other cytoplasmic organelle;other cell component","","TM9SF1","ENSCANG00000029500; ENSCCAG00000032112; ENSG00000100926; ENSG00000285465; ENSPPAG00000042444; ENSPTRG00000032568; ENSRBIG00000029944; ENSRROG00000042511","","","",263,257.6,275.7,303.7,288.8,221.4,0.978375721833149,-0.03153949072105611,0.8317816862834875,0.07999064592537986,0.8859650750577106,0.05258339776156144,6862]
["O15344-1","E3 ubiquitin-protein ligase Midline-1 [OS=Homo sapiens]",10,6,6,6,667,75.2,6.8,19.65,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","MID1","ENSCANG00000031338; ENSCCAG00000029160; ENSCJAG00000000987; ENSCSAG00000015273; ENSG00000101871; ENSMFAG00000037182; ENSMLEG00000034816; ENSMMUG00000020179; ENSMNEG00000026727; ENSPANG00000006683; ENSPPAG00000038224; ENSRBIG00000037000; ENSTSYG00000003295","Ubiquitin mediated proteolysis","Interferon gamma signaling","",377.5,369.2,382.5,346.4,354.8,455.9,0.9758879958516983,-0.035212517900224866,0.8057317121918628,0.09380954294785639,0.8688540992048281,0.06105314556524286,6778]
["O15347","High mobility group protein B3 [OS=Homo sapiens]",23,4,6,3,200,23,8.37,19.09,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","HMGB3","ENSG00000029993","","","",570.4,418.7,383.8,480.5,412.6,797.5,0.8120785519933751,-0.3003088094841728,0.46646865252114206,0.33117753625729357,0.6253520508578553,0.20387542153595659,5452]
["O15355","Protein phosphatase 1G [OS=Homo sapiens]",51,23,124,23,546,59.2,4.36,418.89,"protein metabolism;other metabolic processes;other biological processes","other membranes;nucleus;other cell component","other molecular function","PPM1G","ENSG00000115241","","","VEGFA-VEGFR2 signaling pathway; mRNA processing",16320.6,16280.4,16236,16651.6,18717.2,16347.2,0.9443305746770825,-0.0826361135185642,0.267091383449043,0.5733401223900637,0.5043066188656821,0.2973053318250458,3871]
["O15357","Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 [OS=Homo sapiens]",25,21,39,20,1258,138.5,6.54,114.09,"cell adhesion;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","INPPL1","ENSG00000165458","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; B cell receptor signaling pathway; Fc gamma R-mediated phagocytosis; Insulin signaling pathway","Synthesis of PIPs at the plasma membrane; Interleukin receptor SHC signaling; Synthesis of IP3 and IP4 in the cytosol","EGF/EGFR signaling pathway; Insulin signaling",2777.6,2761.8,2782,2912.5,2956.6,3269,0.9106269355774176,-0.13506796119548445,0.07256376864190713,1.1392801700234532,0.274944834112856,0.5607544357833647,1929]
["O15360","Fanconi anemia group A protein [OS=Homo sapiens]",2,2,2,2,1455,162.7,6.6,5.6,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","","FANCA","ENSG00000187741","Fanconi anemia pathway","Fanconi Anemia Pathway","DNA repair pathways, full network",144.2,151.8,130.6,164.3,174.6,214.2,0.7712890978123307,-0.37465637637535343,0.06216736227379557,1.2064375591114571,0.25398616593581436,0.5951899377948571,1789]
["O15371","Eukaryotic translation initiation factor 3 subunit D [OS=Homo sapiens]",58,23,96,23,548,63.9,6.05,317.05,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity","EIF3D","ENSG00000100353","","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","Translation factors; VEGFA-VEGFR2 signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell",8118.2,8074.5,8430.8,8291.1,8385.6,6068.7,1.0825705417359115,0.1144610359420806,0.4592779325140896,0.3379244211564258,0.620148237344445,0.20750448636351418,5413]
["O15372","Eukaryotic translation initiation factor 3 subunit H [OS=Homo sapiens]",53,18,89,18,352,39.9,6.54,252.59,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3H","ENSG00000147677","Measles","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","Translation factors; VEGFA-VEGFR2 signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell",11037.1,11230.9,11049.3,11781.7,11401.3,13680.3,0.90380676716409,-0.1459137358010794,0.17017926299704303,0.7690933614937286,0.41227717376380096,0.38481070978474413,3017]
["O15379","Histone deacetylase 3 [OS=Homo sapiens]",11,5,13,5,428,48.8,5.16,34.32,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","HDAC3","ENSG00000171720","Neutrophil extracellular trap formation; Thyroid hormone signaling pathway; Alcoholism; Viral carcinogenesis","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Regulation of PTEN gene transcription; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Cytoprotection by HMOX1; Association of TriC/CCT with target proteins during biosynthesis; NR1D1 (REV-ERBA) represses gene expression; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RUNX2 regulates osteoblast differentiation; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; STAT3 nuclear events downstream of ALK signaling","Neural crest differentiation; Initiation of transcription and translation elongation at the HIV-1 LTR; Ethanol effects on histone modifications; Transcription co-factors SKI and SKIL protein partners; 22q11.2 copy number variation syndrome; IL-18 signaling pathway; 7q11.23 copy number variation syndrome; 16p11.2 proximal deletion syndrome",1427.7,1328.9,1344,1539.3,1480,1855,0.8412695156227562,-0.24936002738954965,0.09880428989790505,1.005224198746969,0.3242750583133309,0.4890864538970343,2227]
["O15381-1","Nuclear valosin-containing protein-like [OS=Homo sapiens]",26,17,29,17,856,95,6.48,88.47,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","NVL","ENSG00000143748","Ribosome biogenesis in eukaryotes","","",2138.2,2025.1,2094.8,2484.4,2531,3403.3,0.7433570503759487,-0.42787276019811016,0.07471986596835153,1.1265639158097824,0.27963517683701045,0.5534081972136637,1953]
["O15382","Branched-chain-amino-acid aminotransferase, mitochondrial [OS=Homo sapiens]",49,14,34,14,392,44.3,8.65,113.66,"other metabolic processes;other biological processes","mitochondrion","other molecular function","BCAT2","ENSG00000105552","Cysteine and methionine metabolism; Valine, leucine and isoleucine degradation; Valine, leucine and isoleucine biosynthesis; Pantothenate and CoA biosynthesis; Metabolic pathways; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids; Biosynthesis of cofactors","Branched-chain amino acid catabolism","One-carbon metabolism and related pathways",4758.8,4819.8,4625.9,3826.9,4035.9,4161,1.1813652921705284,0.24045513214943567,0.003005877176242193,2.522028769181596,0.0608586046569368,1.2156780092032806,361]
["O15397-1","Importin-8 [OS=Homo sapiens]",10,8,19,7,1037,119.9,5.16,63.01,"transport;signal transduction","cytosol;nucleus","other molecular function","IPO8","ENSG00000133704","Nucleocytoplasmic transport","Transcriptional regulation by small RNAs","",1032.5,1018.2,993.1,1148.4,1290,1524.3,0.7681126504655916,-0.3806101845269101,0.04985801787026653,1.3022649910772666,0.22904604186912514,0.6400772088398751,1591]
["O15400","Syntaxin-7 [OS=Homo sapiens]",62,11,84,11,261,29.8,5.55,223.5,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","STX7","ENSG00000079950","SNARE interactions in vesicular transport; Phagosome","","",3761.7,3527.4,3916.8,4546.6,5216.7,6621.1,0.6839371597373112,-0.5480643187529719,0.04997859817915045,1.30121592931396,0.2294557626202328,0.6393010308316375,1592]
["O15427","Monocarboxylate transporter 4 [OS=Homo sapiens]",3,2,4,2,465,49.4,7.96,10.11,"transport","plasma membrane;other membranes;nucleus;other cell component","transporter activity","SLC16A3","ENSG00000141526","Central carbon metabolism in cancer","Pyruvate metabolism; Basigin interactions; Proton-coupled monocarboxylate transport","Metabolic reprogramming in colon cancer",439.8,457,503.5,476.6,468.5,567.5,0.9257569747454714,-0.11129458104104081,0.3689301036935068,0.43305590607825384,0.5620071129420261,0.2502581878260927,4798]
["O15439-1","multidrug resistance-associated protein 4 [OS=Homo sapiens]",8,7,13,6,1325,149.4,8.19,35.69,"cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes","transporter activity;other molecular function","ABCC4","ENSG00000125257","Antifolate resistance; ABC transporters; cAMP signaling pathway; Bile secretion","ABC-family proteins mediated transport; Platelet degranulation","Fluoropyrimidine activity; Drug induction of bile acid pathway; Ectoderm differentiation; Pregnane X receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; TYROBP causal network in microglia; Aspirin and miRNAs; Proximal tubule transport; FOXA2 pathway; Prostaglandin synthesis and regulation",459.6,489.4,504,425.6,426.8,604.3,0.9974600123566966,-0.003669089272735306,0.9847845638501742,0.006658767435829279,0.9900674521569358,0.00433521641089415,7270]
["O15446-1","DNA-directed RNA polymerase I subunit RPA34 [OS=Homo sapiens]",17,3,3,3,510,55,8.51,13.7,"RNA metabolism OR transcription;other metabolic processes;signal transduction","cytosol;mitochondrion;nucleus;other cell component","other molecular function","POLR1G","ENSG00000117877","RNA polymerase","B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","",55.5,33.1,43.7,66.1,46,54.9,0.7922155688622755,-0.33603504108273774,0.2543780526227253,0.5945203617186645,0.4952714935054606,0.305156668120019,3754]
["O15498","Synaptobrevin homolog YKT6 [OS=Homo sapiens]",38,8,44,8,198,22.4,6.92,123.61,"cell organization and biogenesis;transport","plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","YKT6","ENSG00000106636","SNARE interactions in vesicular transport","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; COPI-mediated anterograde transport; RAC3 GTPase cycle; Intra-Golgi traffic; COPII-mediated vesicle transport","",6768.9,6769.2,7043.3,5781,6097,5020.4,1.2179496283671827,0.28445446788496936,0.020941014755468768,1.6790022771928663,0.14976308889209514,0.8245952111075874,1022]
["O15504","nucleoporin-like protein 2 [OS=Homo sapiens]",7,2,4,2,423,44.8,9.19,8.16,"transport","other membranes;cytosol;nucleus","other molecular function","NUP42","ENSG00000136243","Nucleocytoplasmic transport","HCMV Early Events; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus","",157.6,153.6,156.8,204.4,190.6,228.6,0.750481077613855,-0.41411239822701795,0.009717747935649494,2.012434370098722,0.10293770965458283,0.9874254989520045,690]
["O15511-1","Actin-related protein 2/3 complex subunit 5 [OS=Homo sapiens]",58,9,39,9,151,16.3,5.67,142.68,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity","Arpc5; ARPC5","ENSDLEG00000020693; ENSG00000162704; ENSGGOG00000007894; ENSPCTG00005002795; ENSPPAG00000038421; ENSPPYG00000000425; ENSPTRG00000001767; ENSRNOG00000028062; ENSSBOG00000027275; ENSSSCG00000015560; ENSSSCG00070012419; ENSSTOG00000001001","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection","Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; EPHB-mediated forward signaling; Neutrophil degranulation; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling","Pathogenic Escherichia coli infection; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton",4084.6,4277.6,3826.5,4410.4,4453.8,3513.1,0.9847624279931809,-0.022152375694918677,0.8595643986418291,0.06572158037648587,0.9078838424383134,0.0419697129492707,6920]
["O15527-1","N-glycosylase/DNA lyase [OS=Homo sapiens]",3,1,1,1,345,38.8,8.6,3.08,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","OGG1","ENSG00000114026","Base excision repair","Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Displacement of DNA glycosylase by APEX1; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; Defective OGG1 Substrate Binding; Defective OGG1 Substrate Processing","Base excision repair; DNA repair pathways, full network",101.1,87.8,115.3,121,102,130.6,0.8602941176470587,-0.21709812166693518,0.22746923726421817,0.6430773286321902,0.4733976808554016,0.32477387398228225,3512]
["O15530-1","3-phosphoinositide-dependent protein kinase 1 [OS=Homo sapiens]",25,10,18,10,556,63.1,7.36,46.45,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function","PDPK1","ENSG00000140992","Platinum drug resistance; PPAR signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Apoptosis; Axon guidance; Focal adhesion; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; Neurotrophin signaling pathway; Insulin signaling pathway; Thyroid hormone signaling pathway; Insulin resistance; Aldosterone-regulated sodium reabsorption; Toxoplasmosis; Proteoglycans in cancer; Chemical carcinogenesis; Endometrial cancer; Prostate cancer; Non-small cell lung cancer; Choline metabolism in cancer; Lipid and atherosclerosis","Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of TP53 Degradation; PIP3 activates AKT signaling; GPVI-mediated activation cascade; CD28 dependent PI3K/Akt signaling; G beta:gamma signalling through PI3Kgamma; RHO GTPases activate PKNs; Activation of AKT2; Integrin signaling; RSK activation; VEGFR2 mediated vascular permeability; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ","MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac hypertrophic response; Focal adhesion; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; PPAR signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; EGF/EGFR signaling pathway; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Modulators of TCR signaling and T cell activation; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway",1897,1990.3,1929.7,1819.7,1788.2,2346.4,0.9769410342105705,-0.03365660763662829,0.8149315519459766,0.08887886716251314,0.874645332330858,0.05816801719132533,6810]
["O15533-1","Tapasin [OS=Homo sapiens]",11,5,40,5,448,47.6,7.15,107.11,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;ER/Golgi","signal transduction activity or receptor binding;transporter activity;other molecular function","TAPBP","ENSG00000112493; ENSG00000206208; ENSG00000206281; ENSG00000231925; ENSG00000236490; ENSPPAG00000024524; ENSPTRG00000018043","Antigen processing and presentation; Human cytomegalovirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection","ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC","",4961.3,4887,4982.2,4419.3,4543.7,7375.9,0.9076804436039145,-0.139743620688101,0.6301652450039563,0.20054555279518899,0.7400189228364262,0.13075717489284852,6224]
["O15534-1","period circadian protein homolog 1 [OS=Homo sapiens]",2,2,2,2,1290,136.1,6.09,0,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PER1","ENSG00000179094","Circadian rhythm; Circadian entrainment","Circadian Clock","Melatonin metabolism and effects; Exercise-induced circadian regulation",167,173.9,163.7,132.4,132.6,290.1,0.9090254008286794,-0.13760748678528226,0.7650505911824679,0.11630984491840957,0.8402336244857488,0.0755999428451305,6655]
["O15541","RING finger protein 113A [OS=Homo sapiens]",29,7,14,7,343,38.8,5.69,43.22,"protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus","other molecular function","RNF113A","ENSG00000125352","","","",1309.4,1262.6,1244.5,1317.8,1347.3,1185,0.9912729539492482,-0.012645726589955487,0.8444919695873924,0.07340447585077567,0.8957178647096576,0.047828763881491224,6891]
["O15550","Lysine-specific demethylase 6A [OS=Homo sapiens]",3,4,5,4,1401,154.1,7.44,12.76,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","KDM6A","ENSG00000147050","Transcriptional misregulation in cancer","Activation of anterior HOX genes in hindbrain development during early embryogenesis; HDMs demethylate histones","Mesodermal commitment pathway; Mesodermal commitment pathway; Pathways affected in adenoid cystic carcinoma",563.3,567.4,586.4,676.6,656.1,724.5,0.8346782033832395,-0.26070799773725084,6.1789299836222476E-3,2.2090867259536986,0.08505046939791903,1.0703232851511946,531]
["O15553","Pyrin [OS=Homo sapiens]",2,2,5,1,781,86.4,8.03,11.75,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","MEFV","ENSG00000103313","NOD-like receptor signaling pathway; Yersinia infection","The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection","Nucleotide-binding oligomerization domain (NOD) pathway",260.5,236.9,214.2,254.3,282.6,239.4,0.916655931985057,-0.12554777695215472,0.3065811038293275,0.5134546164599589,0.5303671687310189,0.2754233678616971,4225]
["O43143","Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 [OS=Homo sapiens]",41,32,171,32,795,90.9,7.46,501.7,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","DHX15","ENSG00000109606","Spliceosome","mRNA Splicing - Major Pathway","mRNA processing",20423.6,20119.7,19735,18872.9,18753.7,13842.8,1.1711482939377569,0.22792376532077652,0.15336248270995692,0.8142808694928853,0.39261869916885295,0.4060290201907792,2855]
["O43148-1","mRNA cap guanine-N7 methyltransferase [OS=Homo sapiens]",41,18,47,18,476,54.8,6.61,140.64,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RNMT","ENSG00000101654","mRNA surveillance pathway","RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE","mRNA processing",5392.7,5147.6,5239.4,6097.7,6281.2,4832.5,0.9168167609839988,-0.1252946756098884,0.3590343898595799,0.44486395083410085,0.5586932841140451,0.25282654913337677,4697]
["O43149","Zinc finger ZZ-type and EF-hand domain-containing protein 1 [OS=Homo sapiens]",14,33,57,21,2961,330.9,5.95,161.32,"","","other molecular function","ZZEF1","ENSG00000074755","","","",4722.7,4794.1,4826.4,4537.7,4605.1,6038.2,0.9448125946907319,-0.08189989838180997,0.5994078525539286,0.22227757187001795,0.7176203102893799,0.14410527826694625,6105]
["O43149-3","Isoform 3 of Zinc finger ZZ-type and EF-hand domain-containing protein 1 [OS=Homo sapiens]",13,13,25,1,1085,119.9,5.67,74.37,"","","","ZZEF1","","","","",327.3,319.3,302.9,287.9,288.2,382.2,0.9908170718981529,-0.013309368278643891,0.931783556235301,0.030684958085356144,0.9566520596325067,0.019245989138384597,7119]
["O43150-1","Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 [OS=Homo sapiens]",4,3,4,3,1006,111.6,6.68,13.77,"other biological processes","plasma membrane;other membranes;ER/Golgi","enzyme regulator activity;other molecular function","ASAP2","ENSG00000151693","Endocytosis; Fc gamma R-mediated phagocytosis","","Vitamin D receptor pathway",98.5,101.7,113.4,96.9,128.8,152.6,0.8289717155696538,-0.2706052169341677,0.26756748645410566,0.5725666611264115,0.504684066707886,0.2969804060847676,3875]
["O43156","TELO2-interacting protein 1 homolog [OS=Homo sapiens]",7,7,9,7,1089,122,5.97,19.69,"other biological processes","nucleus;other cell component","","TTI1","ENSG00000101407","mTOR signaling pathway","","Fragile X syndrome; Malignant pleural mesothelioma",991.3,1021.9,1057.6,1082.4,997.3,1155.1,0.9493013478422159,-0.07506196335660355,0.3310547469909277,0.4801001803934932,0.5458333286164427,0.2629399498088547,4433]
["O43159","ribosomal rna-processing protein 8 [OS=Homo sapiens]",19,8,22,8,456,50.7,9.42,54.26,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","RRP8","ENSG00000132275","","SIRT1 negatively regulates rRNA expression","",1799.3,1750.7,1795.4,2255.8,2264.5,1651.7,0.8660725858716785,-0.2074401520500211,0.24705328654292794,0.607209364328848,0.4897511449260266,0.31002454005099156,3687]
["O43164","E3 ubiquitin-protein ligase Praja-2 [OS=Homo sapiens]",3,1,2,1,708,78.2,4.39,6.64,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component","other molecular function","PJA2","ENSG00000198961","","Antigen processing: Ubiquitination & Proteasome degradation","",40.9,35.4,45.6,84.8,77.9,81.1,0.5,-1,3.3554976516034181E-4,3.474243060795248,0.02250030489501778,1.6478115968518987,109]
["O43166-1","Signal-induced proliferation-associated 1-like protein 1 [OS=Homo sapiens]",1,2,2,2,1804,199.9,8.19,0,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;enzyme regulator activity","SIPA1L1","ENSG00000197555","Rap1 signaling pathway","Neurexins and neuroligins","",87.7,84.9,81.6,92.2,93.8,278.1,0.5477267830209006,-0.868471667165233,0.3203397406667853,0.49438918034435536,0.541105422818011,0.2667181136591067,4327]
["O43169","Cytochrome b5 type B [OS=Homo sapiens]",55,5,29,5,146,16.3,4.97,98.99,"","other membranes","other molecular function","","","","","",2650.2,3189.8,2988.6,2621.4,2054.7,2395.4,1.248476278017394,0.32016840924225604,0.06194129038136098,1.2080197515193143,0.25362963103493974,0.5958000100835532,1785]
["O43172-1","U4/U6 small nuclear ribonucleoprotein Prp4 [OS=Homo sapiens]",43,19,56,1,522,58.4,7.42,166.66,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity","PRPF4","ENSG00000136875; ENSPTRG00000021274","Spliceosome","mRNA Splicing - Major Pathway","mRNA processing; mRNA Processing",150,142.3,157.7,171.4,201.6,210.2,0.7716049382716049,-0.3740657182225377,0.024223990123659406,1.6157543192457864,0.16139757868170157,0.7921029849365245,1097]
["O43172-2","Isoform 2 of U4/U6 small nuclear ribonucleoprotein Prp4 [OS=Homo sapiens]",43,19,57,1,521,58.3,7.42,168.72,"","","","PRPF4","","","","",6594.5,6572.5,6876.5,7079.9,7108.6,7296.6,0.9329023369684107,-0.10020203776124914,0.015695392391276396,1.804227822287235,0.13065788495198083,0.8838643763093647,878]
["O43175","D-3-phosphoglycerate dehydrogenase [OS=Homo sapiens]",43,18,195,18,533,56.6,6.71,658.6,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytosol","other molecular function","PHGDH","ENSG00000092621","Glycine, serine and threonine metabolism; Cysteine and methionine metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids","Serine biosynthesis","Trans-sulfuration and one-carbon metabolism; Clear cell renal cell carcinoma pathways; Neuroinflammation and glutamatergic signaling",14243.9,14518.8,14272.3,15590.3,16148.3,18313.5,0.8598040841443216,-0.21792013162271312,0.04876312030844833,1.311908512049079,0.22788340558468595,0.6422872988889353,1564]
["O43181","NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [OS=Homo sapiens]",23,4,8,4,175,20.1,10.3,15.99,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity","NDUFS4","ENSG00000164258","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",1134.9,1130,1099.7,1026.4,1052,514.3,{"$f":"AVERAGE(S322:U322)/AVERAGE(V322:X322)","v":1.2977205230069044},{"$f":"LOG(Y322,2)","v":0.3759797180940364},{"$f":"TTEST(V322:X322,S322:U322,2,2)","v":0.2164356795781646},0.6646711439045357,{"$f":"AA322*7309/AE322","v":0.46214676658977655},0.3352200811584399,3423]
["O43182","Rho GTPase-activating protein 6 [OS=Homo sapiens]",7,6,7,6,974,105.9,7.36,16.39,"cell adhesion;cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","ARHGAP6","ENSG00000047648","","RHOA GTPase cycle; RAC3 GTPase cycle","",359.5,341.9,379.8,395,386,383.3,0.9286266426178822,-0.10682942197190923,0.07377746400501288,{"$f":"-LOG10(AA323)","v":1.1320762771053907},0.2781018485882616,{"$f":"-LOG10(AC323)","v":0.5557961243001229},1939]
["O43189-2","Isoform 1 of PHD finger protein 1 [OS=Homo sapiens]",18,5,10,5,457,49.6,7.93,27.84,"","","","PHF1","","","","",573.5,528.8,614.5,557.8,567.8,885,0.8538744653337312,-0.22790411116910533,0.42458521889765133,0.37203512901816826,0.5967871855621026,0.22418051076899442,5200]
["O43237","Cytoplasmic dynein 1 light intermediate chain 2 [OS=Homo sapiens]",18,7,14,7,492,54.1,6.38,47.14,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","DYNC1LI2","ENSG00000135720","Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection","Separation of Sister Chromatids; COPI-mediated anterograde transport; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Intraflagellar transport proteins binding to dynein",1300.5,1216.1,1265.7,1491.6,1411.1,1674.7,0.8262987722287761,-0.27526457077723143,0.0316101813028884,1.500173013220269,0.18453579484250107,0.733919380210707,1252]
["O43242","26S proteasome non-ATPase regulatory subunit 3 [OS=Homo sapiens]",57,29,211,29,534,60.9,8.44,648.47,"protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","enzyme regulator activity","PSMD3","ENSG00000108344","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Interleukin-1 signaling; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease",20150.9,20159.1,20184.5,20029,19359.3,19592,1.0256729789438166,0.03657082172467753,0.06212249371108475,1.2067511192147866,0.25394480231225863,0.5952606717907126,1788]
["O43251-1","RNA binding protein fox-1 homolog 2 [OS=Homo sapiens]",2,1,1,1,390,41.3,7.27,2.16,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RBFOX2","ENSG00000100320; ENSG00000277564","","FGFR2 alternative splicing","Mammalian disorder of sexual development",46.5,55.4,69.8,70.1,58.5,752,0.19498069498069495,-2.358596804934759,0.3611028813697505,0.4423690461674952,0.5588187507794847,0.2527290298602221,4723]
["O43252","bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [OS=Homo sapiens]",52,24,106,22,624,70.8,6.86,321.71,"other metabolic processes;developmental processes","cytosol","kinase activity;other molecular function","PAPSS1","ENSG00000138801","Purine metabolism; Selenocompound metabolism; Sulfur metabolism; Metabolic pathways","Signaling by BRAF and RAF1 fusions; Transport and synthesis of PAPS; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se","Sulfation biotransformation reaction",11385.5,11160.1,11324.4,11694.8,11725.5,12200.6,0.9508462728342069,-0.0727159812956598,0.030016291678101166,1.5226429630993252,0.18012239398624091,0.7444322895122087,1218]
["O43264","Centromere/kinetochore protein zw10 homolog [OS=Homo sapiens]",36,19,56,19,779,88.8,6.27,186.12,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","nucleic acid binding activity","ZW10","ENSG00000086827","","COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",3169.1,3120.8,3134.6,2982.9,3055.2,1988.2,1.1742023099061834,0.2316809998899072,0.24756465652796883,0.6063113571095254,0.49036587386529107,0.3094797613846129,3690]
["O43278","Kunitz-type protease inhibitor 1 [OS=Homo sapiens]",17,9,13,9,529,58.4,6.29,35.9,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes","enzyme regulator activity","SPINT1","ENSG00000166145","Transcriptional misregulation in cancer; Prostate cancer","MET Receptor Activation; Signaling by MST1","",1458.7,1474.3,1503.7,1451.6,1433.4,3188.7,0.7304773037851721,-0.45308864626003154,0.40172246179698595,0.3960738845696494,0.5816540161002715,0.23533526892175438,5048]
["O43283","Mitogen-activated protein kinase kinase kinase 13 [OS=Homo sapiens]",2,1,1,1,966,108.2,6.49,0,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;other cell component","kinase activity;other molecular function","MAP3K13","ENSG00000073803","MAPK signaling pathway","","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Insulin signaling",293.1,276.8,276.2,203.3,270.6,49.8,1.6156196295589076,0.6920875798087817,0.17657787094573069,0.7530637239087214,0.4186207131827264,0.3781792867512567,3083]
["O43290","U4/U6.U5 tri-snRNP-associated protein 1 [OS=Homo sapiens]",56,39,111,39,800,90.2,6.13,371.13,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","","SART1","ENSG00000175467","Spliceosome","mRNA Splicing - Major Pathway","",10462.7,10452.4,10499.6,11840.3,12343.4,13451.8,0.8347092505745904,-0.260654335384758,0.012116996023140087,1.9166050346479906,0.1144226407404792,0.9414880334469101,774]
["O43291","Kunitz-type protease inhibitor 2 [OS=Homo sapiens]",13,3,3,3,252,28.2,8.29,4.49,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","enzyme regulator activity","SPINT2","ENSG00000167642","","MET Receptor Activation; Signaling by MST1","",413,407.4,443.9,385.9,378.6,1264.5,0.6231148348940364,-0.68243003040976,0.4352973613099679,0.3612139654453899,0.6052098942009806,0.21809398057984222,5257]
["O43292-1","Glycosylphosphatidylinositol anchor attachment 1 protein [OS=Homo sapiens]",10,6,10,6,621,67.6,8.06,27.83,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi","cytoskeletal activity","GPAA1","ENSG00000197858","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways","Attachment of GPI anchor to uPAR","",1423.2,1463.9,1470.7,1107.1,1215.3,1366.1,1.1814558763725094,0.24056575023664825,0.04349052348736876,1.361605364781035,0.21682962903763867,0.6638813732021712,1466]
["O43298","Zinc finger and BTB domain-containing protein 43 [OS=Homo sapiens]",2,1,1,1,467,52.6,5.76,2.49,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB43","ENSG00000169155","","","",63,44.2,53.1,37.7,57.2,0.6,1.6785340314136128,0.7472017872314372,0.2838420929614001,0.5469231994870525,0.5169703108534447,0.2865343973369182,4013]
["O43299","AP-5 complex subunit zeta-1 [OS=Homo sapiens]",3,2,2,2,807,88.5,7.01,4.08,"DNA metabolism;stress response;transport","other membranes;nucleus;other cell component","","AP5Z1","ENSG00000242802","","","",109.5,85.1,100,143.6,110.1,1476.2,0.17029886120585006,-2.5538593071883815,0.3475694023834914,0.4589584628358581,0.5533401790505202,0.25700779371790594,4591]
["O43301","Heat shock 70 kDa protein 12A [OS=Homo sapiens]",2,1,4,1,675,74.9,6.77,0,"","nucleus;other cell component","other molecular function","HSPA12A","ENSG00000165868","","Regulation of HSF1-mediated heat shock response","",293.5,259.9,158.6,72.2,126.1,3.4,3.529995042141795,1.8196661572407988,0.034309611948020874,1.4645841939166124,0.19289919517544968,0.7146695843394761,1300]
["O43303","centriolar coiled-coil protein of 110 kDa [OS=Homo sapiens]",12,9,9,8,1012,113.4,8.65,21.8,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;other cell component","","CCP110","ENSG00000103540","","Ub-specific processing proteases; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; RHOV GTPase cycle","Genotoxicity pathway; Joubert syndrome",554.3,581.6,568.2,722.8,782.8,808.7,0.7363349608953031,-0.441565893155645,1.5788764229442917E-3,2.8016518604499905,0.045793681648015186,1.3391944393475617,252]
["O43310","CBP80/20-dependent translation initiation factor [OS=Homo sapiens]",15,6,7,1,598,67.5,6.54,17.4,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity","CTIF","ENSG00000134030; ENSG00000282825","","","",405.8,350,385.1,489.9,442.7,1097.1,0.5621027738089374,-0.831094160688773,0.23358248209342394,0.6315597309750407,0.4802403267569158,0.3185413741568528,3555]
["O43310-2","Isoform 2 of CBP80/20-dependent translation initiation factor [OS=Homo sapiens]",15,6,7,1,600,67.7,6.54,15.96,"","","","CTIF","","","","",25.1,24.1,29.7,38,23.5,210.6,0.28996692392502754,-1.7860397512362203,0.34441865254318693,0.46291333666895634,0.5519307019158415,0.2581154470259217,4561]
["O43314-1","inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 [OS=Homo sapiens]",15,16,30,13,1243,140.3,8.22,88.09,"other metabolic processes;other biological processes","cytosol","kinase activity;other molecular function","PPIP5K2","ENSG00000145725","Phosphatidylinositol signaling system","Synthesis of pyrophosphates in the cytosol","",2886.3,2979,2887.2,2710.5,2746.6,2651.8,1.0793695815708666,0.11018893545151409,6.561598405323138E-3,2.1829903536039335,0.08703942421870565,1.0602839905717456,551]
["O43318","mitogen-activated protein kinase kinase kinase 7 [OS=Homo sapiens]",3,2,2,2,606,67.2,7.11,3.79,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle","signal transduction activity or receptor binding;kinase activity;other molecular function","MAP3K7","ENSG00000135341","MAPK signaling pathway; NF-kappa B signaling pathway; Autophagy; AMPK signaling pathway; Wnt signaling pathway; Osteoclast differentiation; Adherens junction; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; IL-17 signaling pathway; T cell receptor signaling pathway; TNF signaling pathway; Alcoholic liver disease; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Leishmaniasis; Toxoplasmosis; Hepatitis B; Measles; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Ca2+ pathway; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; TNFR1-induced NFkappaB signaling pathway; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway","Regulation of toll-like receptor signaling pathway; IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; Fas ligand pathway and stress induction of heat shock proteins; Wnt signaling pathway; IL-6 signaling pathway; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Angiopoietin-like protein 8 regulatory pathway; Wnt signaling pathway and pluripotency; p38 MAPK signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; miRNAs involvement in the immune response in sepsis; Signal transduction through IL1R; Hepatitis B infection; IL-18 signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - interferon induction; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway",107.4,110.3,122.4,141.2,128.3,97.7,0.9261982570806101,-0.11060705270596592,0.5454854168081202,0.26321685549620905,0.6821134151326862,0.166143409110095,5845]
["O43324-1","Eukaryotic translation elongation factor 1 epsilon-1 [OS=Homo sapiens]",53,8,37,8,174,19.8,8.54,111.53,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","EEF1E1","ENSANAG00000036153; ENSG00000124802; ENSPTRG00000017709","","Selenoamino acid metabolism; Cytosolic tRNA aminoacylation","",5070.1,5836.2,4979.3,5300,5283.6,2630.4,1.202179506583926,0.26565233192500454,0.3915116780967519,0.4072552791811659,0.5741490479954173,0.2409753509483061,4984]
["O43353-1","Receptor-interacting serine/threonine-protein kinase 2 [OS=Homo sapiens]",10,4,5,4,540,61.2,7.09,10.76,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","RIPK2","ENSG00000104312","NOD-like receptor signaling pathway; Neurotrophin signaling pathway; Shigellosis; Salmonella infection; Tuberculosis","Downstream TCR signaling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; p75NTR recruits signalling complexes; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; activated TAK1 mediates p38 MAPK activation; Ovarian tumor domain proteases","Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Fas ligand pathway and stress induction of heat shock proteins; T-cell receptor (TCR) signaling pathway",244,254.3,240.8,260.4,227.8,276.2,0.9669021454735741,-0.04855820454767903,0.5997588954438055,0.22202330198704395,0.7178054309478916,0.14399326009893657,6107]
["O43379-4","Isoform 4 of WD repeat-containing protein 62 [OS=Homo sapiens]",7,10,16,10,1523,166.4,5.88,35.16,"","","","WDR62","","","","",1268.2,1184.4,1289.5,1240.3,1151.1,1239.4,1.0306544012338879,0.043560649669350235,0.4431192755248245,0.35347935790792495,0.6116636043080156,0.21348736046745578,5295]
["O43390-1","heterogeneous nuclear ribonucleoprotein r [OS=Homo sapiens]",58,32,239,23,633,70.9,8.13,774.29,"RNA metabolism OR transcription;other metabolic processes;other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity","Hnrnpr; HNRNPR; LOC111154612","ENSAMEG00000009537; ENSCAFG00000013308; ENSCANG00000026442; ENSCATG00000035305; ENSFCAG00000019123; ENSG00000125944; ENSG00000282958; ENSGGOG00000013250; ENSLCNG00005013650; ENSMFAG00000039737; ENSMMUG00000010970; ENSMPUG00000015898; ENSNLEG00000008411; ENSRROG00000036942; ENSSSUG00005005658; ENSUAMG00000027050; ENSUMAG00000013292","","mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA","mRNA Processing; mRNA processing",26272.9,25816.5,26415.2,30181.9,28766.6,24215.1,0.9439778941748553,-0.08317501955631237,0.4390388893062839,0.3574970089991437,0.6079831833913658,0.21610843299920168,5278]
["O43395","U4/U6 small nuclear ribonucleoprotein Prp3 [OS=Homo sapiens]",42,24,72,24,683,77.5,9.5,192.25,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","other molecular function","PRPF3","ENSG00000117360","Spliceosome","mRNA Splicing - Major Pathway","mRNA processing",8072.2,7923,8081.6,9392.2,9415.7,8312.7,0.8877679697351829,-0.1717454370666811,0.05077662855713689,1.2943361385871495,0.23123138823932304,0.6359532134440674,1605]
["O43396","Thioredoxin-like protein 1 [OS=Homo sapiens]",59,13,79,13,289,32.2,4.96,327.32,"","cytosol;nucleus;other cell component","other molecular function","TXNL1","ENSG00000091164","","RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle","",8971.5,8947.2,9466.9,8421.9,8617.9,6289.4,1.1738765152684192,0.23128065361002298,0.151733152944758,0.8189195176451,0.39077435337323335,0.40807394688258225,2838]
["O43399","Tumor protein D54 [OS=Homo sapiens]",60,11,30,11,206,22.2,5.36,92.73,"other metabolic processes;other biological processes","other cell component","other molecular function","TPD52L2","ENSG00000101150","","","",2270.6,2930.9,2469.7,2426.5,2858.8,2903.4,0.9368031555680387,-0.09418215940402723,0.5245665999543796,0.2801993651320395,0.6672567488803621,0.17570702490399517,5746]
["O43402","ER membrane protein complex subunit 8 [OS=Homo sapiens]",29,5,10,5,210,23.8,6.4,41.53,"cell organization and biogenesis","other membranes;cytosol;ER/Golgi;other cell component","","EMC8","ENSG00000131148","","","",1152.3,1154.9,1154.7,1071.4,1102,659.6,1.2219908224496998,0.2892334500862453,0.21559924777398595,0.6663527587365835,0.4613041282143042,0.336012658869578,3416]
["O43414-1","ERI1 exoribonuclease 3 [OS=Homo sapiens]",3,1,3,1,337,37.2,8.07,8.56,"RNA metabolism OR transcription;other metabolic processes","","nucleic acid binding activity;other molecular function","ERI3","ENSG00000117419; ENSMFAG00000044436; ENSMLEG00000012810; ENSMMUG00000011651; ENSMNEG00000035539; ENSNLEG00000014004; ENSPANG00000013867; ENSPPAG00000042776; ENSPTRG00000000655; ENSRBIG00000044795; ENSRROG00000036414","","","",638.2,634.7,649.6,629.2,593.6,494.2,1.119685497961561,0.1630935588470548,0.16721090742686648,0.7767353962702415,0.409291534622561,0.38796723777527503,2986]
["O43422-1","52 kDa repressor of the inhibitor of the protein kinase [OS=Homo sapiens]",16,7,11,7,761,87.6,5.86,27.98,"other metabolic processes;signal transduction;other biological processes","","nucleic acid binding activity;kinase activity;other molecular function","THAP12","ENSG00000137492; ENSPTRG00000004091","","","",450.3,435.9,443.1,363.3,392,274.4,1.2909585316111494,0.368442658894668,0.04871938675277613,1.3122981869507466,0.2279705491523948,0.6421212546080552,1562]
["O43426","Synaptojanin-1 [OS=Homo sapiens]",7,9,12,9,1573,173,7.42,33.23,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity;other molecular function","SYNJ1","ENSG00000159082","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; Synthesis of IP3 and IP4 in the cytosol; Synthesis of IP2, IP, and Ins in the cytosol","VEGFA-VEGFR2 signaling pathway; EGF/EGFR signaling pathway",1008.4,926.3,898,1013.9,1081.3,1042.3,0.9028525896414342,-0.14743763935586007,0.05740231591605257,1.241070585489266,0.24549650499147352,0.6099546863260299,1709]
["O43427","Acidic fibroblast growth factor intracellular-binding protein [OS=Homo sapiens]",23,9,17,9,364,41.9,6.48,41.38,"signal transduction","other membranes;mitochondrion;nucleus;other cell component","other molecular function","FIBP","ENSG00000172500","","","Modulators of TCR signaling and T cell activation",2149.9,2039.2,2192.5,2162.2,2092.2,1377.9,1.133036237416331,0.18019400299850735,0.3823200789652166,0.41757289278713094,0.5688879188022736,0.24497328903626925,4912]
["O43432","Eukaryotic translation initiation factor 4 gamma 3 [OS=Homo sapiens]",15,23,56,17,1585,176.5,5.38,136.67,"protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus","nucleic acid binding activity","EIF4G3","ENSG00000075151","Viral myocarditis","ISG15 antiviral mechanism","Translation factors; Translation inhibitors in chronically activated PDGFRA cells",2177.3,2144.5,2166.7,2511.6,2561.4,2319.5,0.8777138992221848,-0.18817734127401037,0.015458554762413642,1.8108311111970041,0.12957176233770792,0.8874896342455985,872]
["O43447","peptidyl-prolyl cis-trans isomerase H [OS=Homo sapiens]",47,8,66,7,177,19.2,8.07,156.88,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","PPIH","ENSG00000171960","Spliceosome","mRNA Splicing - Major Pathway","",5869.8,6239.4,5569,6010.3,6148.1,6364,0.954422752990973,-0.06729965827085457,0.26909743091157967,0.5700904484504798,0.5057426388615932,0.29607042971396663,3889]
["O43463","Histone-lysine N-methyltransferase SUV39H1 [OS=Homo sapiens]",8,3,4,3,412,47.9,8.03,9.35,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SUV39H1","ENSG00000101945","Lysine degradation; Metabolic pathways","PKMTs methylate histone lysines; SIRT1 negatively regulates rRNA expression","Histone modifications; Retinoblastoma gene in cancer; Interactions between LOXL4 and oxidative stress pathway; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome",228.6,201.8,232.9,263.5,291.9,215.6,0.8603112840466925,-0.21706933426501468,0.21359962569359997,0.6703995126891109,0.45944663454812307,0.33776492533816477,3398]
["O43464","Serine protease HTRA2, mitochondrial [OS=Homo sapiens]",30,9,36,9,458,48.8,10.07,113.17,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","HTRA2","ENSG00000115317","Apoptosis; Apoptosis; Parkinson disease; Pathways of neurodegeneration","","Parkinson's disease pathway; Nanomaterial induced apoptosis; Ciliary landscape; Complement system in neuronal development and plasticity",1975.7,1943.4,2026.9,1957.7,2058.9,1810.7,1.0203696394556656,0.029091878084401723,0.6303202759746067,0.20043872238056462,0.7398443708203629,0.1308596262179917,6227]
["O43488","aflatoxin B1 aldehyde reductase member 2 [OS=Homo sapiens]",39,11,37,11,359,39.6,7.17,96.56,"other metabolic processes","cytosol;ER/Golgi","other molecular function","AKR7A2","ENSG00000053371","Metabolism of xenobiotics by cytochrome P450","Aflatoxin activation and detoxification","Aflatoxin B1 metabolism; Metapathway biotransformation Phase I and II",5035.4,4928.3,5024.1,4891.3,5124.2,4580.6,1.0268359356266399,0.03820569113422082,0.4630871010111201,0.33433731582690435,0.6224169954561009,0.20591855719441274,5438]
["O43491-1","band 4.1-like protein 2 [OS=Homo sapiens]",48,43,149,40,1005,112.5,5.44,466.01,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","EPB41L2","ENSG00000079819","","Neurexins and neuroligins","Splicing factor NOVA regulated synaptic proteins",15795.1,15791.6,16034.8,15141.3,15325.6,14363.1,1.0622685701539147,0.08714856448884056,0.0382731723919138,1.4171055384234923,0.20374261981973632,0.6909181137762744,1373]
["O43493-1","Trans-Golgi network integral membrane protein 2 [OS=Homo sapiens]",37,16,34,2,480,51.1,5.73,98.24,"","","","","","","","",3752.2,3632.7,3591.9,5425.7,5494.7,3340.7,0.7697021968852332,-0.3776277298347408,0.1971478579556368,0.7052079372471147,0.4441904111583691,0.3524308209022602,3244]
["O43493-4","Isoform 4 of Trans-Golgi network integral membrane protein 2 [OS=Homo sapiens]",44,15,33,1,379,39.5,5.59,87.4,"","","","TGOLN2","","","","",463.9,406.7,408.8,741,712.3,783,0.5721057103250905,-0.8056463505564814,3.2877382837273578E-4,3.4831027612222765,0.022669885958267223,1.6445506646030736,106]
["O43502","DNA repair protein RAD51 homolog 3 [OS=Homo sapiens]",2,1,1,1,376,42.2,6.74,2.89,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","RAD51C","ENSG00000108384","Homologous recombination; Fanconi anemia pathway","Resolution of D-loop Structures through Holliday Junction Intermediates; Factors involved in megakaryocyte development and platelet production; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Meiotic recombination","DNA repair pathways, full network",27.4,18.8,23.5,32.7,29.1,33.7,0.7298429319371729,-0.45434207705468777,0.03932762591524958,1.4053022697872206,0.2060542063186804,0.6860185155128641,1395]
["O43504","Ragulator complex protein LAMTOR5 [OS=Homo sapiens]",37,2,2,2,91,9.6,4.87,3.67,"cell organization and biogenesis;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","LAMTOR5","ENSG00000134248","mTOR signaling pathway","mTORC1-mediated signalling; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK","",59,63.7,55.9,67.9,78,54.8,0.8898854010961635,-0.16830853624139405,0.3573719852888525,0.44687949523084386,0.55872338833716,0.2528031485554075,4675]
["O43513","Mediator of RNA polymerase II transcription subunit 7 [OS=Homo sapiens]",6,1,2,1,233,27.2,5.78,6.96,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","MED7","ENSG00000155868","","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Generic Transcription Pathway","",46.3,60.2,50.3,58,63,109.3,0.6808510638297873,-0.5545888516776372,0.2195092870732952,0.6585471007550612,0.4651763929309118,0.33238233323847893,3449]
["O43521","Bcl-2-like protein 11 [OS=Homo sapiens]",15,2,2,2,198,22.2,8.21,4.69,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;other cell component","cytoskeletal activity;other molecular function","BCL2L11","ENSG00000153094","EGFR tyrosine kinase inhibitor resistance; FoxO signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Apoptosis; Non-alcoholic fatty liver disease; Epstein-Barr virus infection; Pathways in cancer; MicroRNAs in cancer; Colorectal cancer","NRAGE signals death through JNK; Signaling by BRAF and RAF1 fusions; Activation of BIM and translocation to mitochondria ; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; RUNX3 regulates BCL2L11 (BIM) transcription; FLT3 Signaling; FOXO-mediated transcription of cell death genes","Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Photodynamic therapy-induced unfolded protein response; BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Nonalcoholic fatty liver disease; EGFR tyrosine kinase inhibitor resistance; Host-pathogen interaction of human coronaviruses - apoptosis; Unfolded protein response; Galanin receptor pathway; ErbB signaling pathway; DNA damage response (only ATM dependent)",68.9,92.6,74.9,70.5,91,130.5,0.8095890410958905,-0.30473833358984703,0.3843603089622787,0.41526146618729726,0.5704141113107197,0.24380973913695486,4925]
["O43524","Forkhead box protein O3 [OS=Homo sapiens]",11,7,16,7,673,71.2,5.16,48.59,"RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","FOXO3","ENSG00000118689","EGFR tyrosine kinase inhibitor resistance; Chemokine signaling pathway; FoxO signaling pathway; Mitophagy; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Neurotrophin signaling pathway; Prolactin signaling pathway; Alcoholic liver disease; Shigellosis; Chemical carcinogenesis; Endometrial cancer; Non-small cell lung cancer","AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of localization of FOXO transcription factors; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; MAPK6/MAPK4 signaling; Signaling by NODAL; Interleukin-4 and Interleukin-13 signaling; FOXO-mediated transcription of cell cycle genes; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; RUNX3 regulates BCL2L11 (BIM) transcription; FLT3 Signaling; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation","IL-5 signaling pathway; Energy metabolism; Glioblastoma signaling pathways; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Kit receptor signaling pathway; Copper homeostasis; NAD metabolism, sirtuins and aging; Imatinib and chronic myeloid leukemia; Pathways affected in adenoid cystic carcinoma; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Non-small cell lung cancer; Overview of leukocyte-intrinsic Hippo pathway functions; Gastrin signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; DNA damage response (only ATM dependent)",1460.2,1368.4,1368,2468.2,2578.4,2778.4,0.5363067092651758,-0.8988697931144167,2.2688002827183284E-4,3.6442037323789904,0.01906053019125088,1.719865023113636,87]
["O43566","Regulator of G-protein signaling 14 [OS=Homo sapiens]",27,12,22,1,566,61.4,8.19,49.83,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","RGS14","ENSG00000169220","Rap1 signaling pathway","G alpha (i) signalling events","Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells",1541.2,1442.8,1523.7,1507.3,1661.7,2534.2,0.790380838827325,-0.33938012274194285,0.28242791229884334,0.5490923842550431,0.5163245650305768,0.2870772121531683,3998]
["O43566-5","Isoform 3 of Regulator of G-protein signaling 14 [OS=Homo sapiens]",36,12,24,1,414,44.8,9.2,56.83,"","","","RGS14","","","","",143.8,128.6,143.4,145.3,142.3,573.5,0.48287074671931246,-1.0502910300956596,0.3588652122714625,0.4450686393284894,0.559025114341884,0.25256868088800805,4692]
["O43567","E3 ubiquitin-protein ligase RNF13 [OS=Homo sapiens]",8,2,5,2,381,42.8,4.98,13.39,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RNF13","ENSG00000082996","","","",924.4,977.5,910.1,954.4,1071.8,408.9,1.1547780378629215,0.2076155750630949,0.573570702134552,0.24141304044042564,0.7019806198763296,0.15367487760944043,5972]
["O43572","A-kinase anchor protein 10, mitochondrial [OS=Homo sapiens]",9,4,5,4,662,73.8,6.39,16.72,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;other cell component","other molecular function","AKAP10","ENSG00000108599","","Factors involved in megakaryocyte development and platelet production","G protein signaling pathways",201.6,199.7,211.2,251.1,230,339.8,0.7461322938238517,-0.4224966430632577,0.10924568250778416,0.9615957177451528,0.33805109798873595,0.4710176491386759,2362]
["O43583","density-regulated protein [OS=Homo sapiens]",22,5,11,5,198,22.1,5.3,35.13,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","","nucleic acid binding activity","DENR","ENSG00000139726","","","",956.9,1025.3,818.4,1045.8,1092.6,855.3,0.9354978788789792,-0.09619371254289263,0.5340421886315094,0.2724244329225183,0.6736821464804457,0.17154496190628835,5794]
["O43592","Exportin-T [OS=Homo sapiens]",29,21,53,21,962,109.9,5.39,161.81,"transport","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","XPOT","ENSG00000184575","Nucleocytoplasmic transport","tRNA processing in the nucleus","",4353.9,4583.6,4536.2,4513.4,4113,6574.5,0.8863751488398715,-0.17401066154636957,0.49397715306435763,0.3062931371644754,0.6443831896747082,0.1908557977480708,5603]
["O43598-1","2'-deoxynucleoside 5'-phosphate N-hydrolase 1 [OS=Homo sapiens]",68,8,60,8,174,19.1,5.05,166.11,"other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","C6orf108; DNPH1","ENSG00000112667","","Purine catabolism","",5450.9,6180.5,5231.6,5684.6,5691.1,6981.2,0.9186191568293121,-0.12246122513813888,0.39067473509812156,0.40818467365429495,0.5734970152304019,0.24146883804578143,4979]
["O43615","Mitochondrial import inner membrane translocase subunit TIM44 [OS=Homo sapiens]",56,29,144,29,452,51.3,8.32,402.17,"cell organization and biogenesis;transport","other membranes;mitochondrion;nucleus","other molecular function","TIMM44","ENSG00000104980","","Mitochondrial protein import","",18054.8,17811.6,18297.4,17154.6,17212.4,17275.2,1.0488282838453822,0.06877849648205883,0.004348193294116199,2.36169115807651,0.07255923467282031,1.1393073066966364,438]
["O43617-1","Trafficking protein particle complex subunit 3 [OS=Homo sapiens]",47,9,26,9,180,20.3,4.96,60.57,"transport","other membranes;cytosol;ER/Golgi;other cell component","","TRAPPC3","ENSCANG00000028241; ENSCATG00000041647; ENSCSAG00000001096; ENSG00000054116; ENSGGOG00000004752; ENSMMUG00000022499; ENSMNEG00000014589; ENSPPAG00000041117; ENSPPYG00000001546; ENSRBIG00000043692; ENSRROG00000034420","","COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs","",5132.5,5093,4970.9,5092.8,5009.6,4117.2,1.068693915440659,0.09584871002077576,0.36108775987403646,0.44238723300563076,0.5589136884623745,0.252655253864366,4722]
["O43633","charged multivesicular body protein 2a [OS=Homo sapiens]",33,9,33,9,222,25.1,5.97,66.06,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle","other molecular function","CHMP2A","ENSG00000130724","Endocytosis; Necroptosis","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Lysosome Vesicle Biogenesis; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","",3515.5,3487.9,3409.5,3656.7,3612.8,3639.6,0.954515037904135,-0.06716016814466347,0.008443054426012528,2.0735004111483444,0.09627189516337842,1.0165004787831888,641]
["O43639","Cytoplasmic protein NCK2 [OS=Homo sapiens]",22,8,11,7,380,42.9,6.95,32.89,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","NCK2","ENSG00000071051","ErbB signaling pathway; Axon guidance; T cell receptor signaling pathway; Pathogenic Escherichia coli infection","RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; Downstream signal transduction; VEGFA-VEGFR2 Pathway; Ephrin signaling; Activation of RAC1; Regulation of cortical dendrite branching","Pathogenic Escherichia coli infection; Brain-derived neurotrophic factor (BDNF) signaling pathway; EGF/EGFR signaling pathway; Genes controlling nephrogenesis; ErbB signaling pathway",928.7,889.3,968,1010.2,1007.6,874.6,0.9632139399806389,-0.0540718234340484,0.518909844540977,0.2849080899732803,0.6630615478583918,0.17844615688233156,5720]
["O43660-1","Pleiotropic regulator 1 [OS=Homo sapiens]",37,13,23,13,514,57.2,9.17,85.7,"RNA metabolism OR transcription;other metabolic processes;other biological processes","other membranes;nucleus;other cell component","","PLRG1","ENSG00000171566","Spliceosome","mRNA Splicing - Major Pathway","",1979.5,2155,2104,2478.4,2522.9,2725.3,0.8074055858980664,-0.3086345269944252,5.7546642843922715E-3,2.2399800071668854,0.08296023916099234,1.0811300046162486,507]
["O43663-1","Protein regulator of cytokinesis 1 [OS=Homo sapiens]",25,12,17,12,620,71.6,6.68,47.23,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","PRC1","ENSG00000198901","","RHO GTPases activate CIT","",1199.2,1209.4,1230.1,1730.3,1321.3,1622.7,0.7784481098774148,-0.36132722015279733,0.04820078701293979,1.3169458706286497,0.22641359400872554,0.6450975013983468,1556]
["O43670-1","BUB3-interacting and GLEBS motif-containing protein ZNF207 [OS=Homo sapiens]",13,6,33,6,478,50.7,9.1,112.27,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","LOC111151255; Znf207; ZNF207","ENSAMEG00000005671; ENSANAG00000033773; ENSCANG00000036057; ENSCJAG00000014376; ENSECAG00000017464; ENSG00000010244; ENSGGOG00000024003; ENSMFAG00000001904; ENSMLEG00000018149; ENSMMUG00000016875; ENSMNEG00000041308; ENSNLEG00000005954; ENSOCUG00000008195; ENSPCOG00000020744; ENSPPAG00000032098; ENSPTRG00000008989; ENSRROG00000037743; ENSSBOG00000026038; ENSSTOG00000000712","","","",3414.4,3472.9,3434.5,3916.2,4030.8,4956,0.7999534991862357,-0.32201195544139477,0.05939947048451627,1.2262174265116965,0.24965539377304738,0.6026590466304361,1739]
["O43674-1","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [OS=Homo sapiens]",25,6,26,6,189,21.7,9.63,70.78,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB5","ENSG00000136521; ENSGGOG00000005222; ENSPTRG00000015649","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",3314.8,3262.8,3248.9,3228.6,3310.1,1843.9,1.1722496600100207,0.22927986063098504,0.3692867040522073,0.4326363285816449,0.5619647137034319,0.2502909533366341,4803]
["O43676","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [OS=Homo sapiens]",11,1,5,1,98,11.4,9.2,14.66,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity","NDUFB3","ENSG00000119013","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease",548.1,590.7,565.9,759.8,804.6,422.1,0.8581424616159076,-0.22071092314649274,0.48212439115869776,0.3168408965657977,0.6357292395776515,0.196727813274286,5543]
["O43678","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [OS=Homo sapiens]",29,2,3,2,99,10.9,9.57,10.45,"cell organization and biogenesis;other metabolic processes;transport;developmental processes","other membranes;mitochondrion","transporter activity","NDUFA2","ENSG00000131495","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",176.1,180.3,172.1,198.6,191.7,230.1,0.8518697614442295,-0.23129521476604542,0.06388714430199396,1.1945865240075346,0.25558354554092716,0.5924671094760995,1827]
["O43681","ATPase ASNA1 [OS=Homo sapiens]",50,11,55,11,348,38.8,4.91,159.62,"cell organization and biogenesis;transport","ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","GET3","ENSG00000198356","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",5873.3,5985.2,6297.4,5886.9,5263,4360.5,1.1705629770992367,0.22720255453077712,0.1282515810345186,0.8919372723733794,0.3630483368633991,0.4400355484198079,2582]
["O43683","Mitotic checkpoint serine/threonine-protein kinase BUB1 [OS=Homo sapiens]",14,13,24,13,1085,122.3,6.47,63.69,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","BUB1","ENSG00000169679","Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Cell cycle; ATM signaling in development and disease ; Regulation of sister chromatid separation at the metaphase-anaphase transition",1715.9,1704.4,1747.5,1320.6,1271.7,1747.3,{"$f":"AVERAGE(S386:U386)/AVERAGE(V386:X386)","v":1.1908470826804314},{"$f":"LOG(Y386,2)","v":0.2519881678430658},{"$f":"TTEST(V386:X386,S386:U386,2,2)","v":0.14269392643426493},0.8455945116240969,{"$f":"AA386*7309/AE386","v":0.38105586712022005},0.4190113471502477,2737]
["O43684","Mitotic checkpoint protein BUB3 [OS=Homo sapiens]",40,11,57,11,328,37.1,6.84,184.97,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","BUB3","ENSG00000154473","Cell cycle; Human T-cell leukemia virus 1 infection","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A","Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition",4149.7,4161.9,4225.6,4480.1,4289,4940.3,0.9144966227551898,-0.1289502527901735,0.11523500531866741,{"$f":"-LOG10(AA387)","v":0.9384155737997331},0.34646345284826824,{"$f":"-LOG10(AC387)","v":0.46034257075909585},2431]
["O43707","Alpha-actinin-4 [OS=Homo sapiens]",72,59,636,38,911,104.8,5.44,2080.36,"transport;signal transduction;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function","ACTN4","ENSG00000130402; ENSG00000282844","Focal adhesion; Adherens junction; Tight junction; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Shigellosis; Amoebiasis; Viral carcinogenesis; Systemic lupus erythematosus","Platelet degranulation ; Nephrin family interactions","Arrhythmogenic right ventricular cardiomyopathy; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Striated muscle contraction pathway; Ebola virus pathway in host; Nephrotic syndrome",65566,64837.1,67774.2,64818.1,64268.4,78807.3,0.9532621944473572,-0.06905501338265316,0.5399094312611675,0.26767908610736874,0.6785072271471585,0.16844552207437716,5816]
["O43708","maleylacetoacetate isomerase [OS=Homo sapiens]",5,2,4,2,216,24.2,8.54,8.57,"other metabolic processes;other biological processes","cytosol;mitochondrion","other molecular function","GSTZ1","ENSG00000100577","Tyrosine metabolism; Metabolic pathways","Regulation of pyruvate dehydrogenase (PDH) complex; Glutathione conjugation; Tyrosine catabolism","Metapathway biotransformation Phase I and II",633.2,617.2,643.5,585.4,583,866.6,0.9306633906633908,-0.10366863755682718,0.6446261573455146,0.19069207586318962,0.7494150761950639,0.12527757432940412,6287]
["O43709-1","Probable 18S rRNA (guanine-N(7))-methyltransferase [OS=Homo sapiens]",16,3,9,3,281,31.9,8.73,35.36,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","BUD23","ENSG00000071462; ENSGGOG00000001453","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","7q11.23 copy number variation syndrome",782,736.5,756.7,1116.2,1101.8,1123.9,0.680810317484066,-0.5546751940704389,1.7187143316855006E-5,4.764796301604077,0.009663140807914864,2.0148816920269415,13]
["O43719","HIV Tat-specific factor 1 [OS=Homo sapiens]",66,46,151,46,755,85.8,4.4,460.43,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","","HTATSF1","ENSG00000102241","","","",15754.2,15271.9,15518,14812.8,15296.4,16307.7,1.0027403811973656,0.003948127144276999,0.9312741869256167,0.03092243466037997,0.9563977844933725,0.019361438603332438,7117]
["O43739","cytohesin-3 [OS=Homo sapiens]",18,6,17,2,400,46.3,5.47,57.64,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","CYTH3","ENSG00000008256","Phospholipase D signaling pathway; Endocytosis; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection","Intra-Golgi traffic","Insulin signaling",420.8,437.3,426,586.6,611.6,1137.7,0.5497238751658889,-0.8632209561785376,0.12287981559878282,0.9105194490418208,0.35654171187435635,0.4478896546559608,2519]
["O43741","5'-AMP-activated protein kinase subunit beta-2 [OS=Homo sapiens]",4,1,1,1,272,30.3,6.46,2.61,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","PRKAB2","ENSG00000131791","FoxO signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Apelin signaling pathway; Tight junction; Circadian rhythm; Thermogenesis; Insulin signaling pathway; Adipocytokine signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Insulin resistance; Non-alcoholic fatty liver disease; Alcoholic liver disease; Hypertrophic cardiomyopathy","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Carnitine metabolism; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; AMPK inhibits chREBP transcriptional activation activity; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Lipophagy","AMP-activated protein kinase (AMPK) signaling; Target of rapamycin (TOR) signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Angiopoietin-like protein 8 regulatory pathway; Lipid metabolism pathway; Caloric restriction and aging; Genotoxicity pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; Malignant pleural mesothelioma",64.7,58.7,59.5,65.9,60.9,49.3,1.0386144236229413,0.05466016591750784,0.6889554484205316,0.1618088610106603,0.78155756208376,0.10703903047303355,6443]
["O43747-1","AP-1 complex subunit gamma-1 [OS=Homo sapiens]",28,21,71,21,822,91.3,6.8,217.4,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","AP1G1","ENSCANG00000031796; ENSCCAG00000037984; ENSCJAG00000015028; ENSG00000166747; ENSGGOG00000004800; ENSMFAG00000037769; ENSMLEG00000040277; ENSMMUG00000010878; ENSMNEG00000034875; ENSPANG00000016832; ENSPPAG00000031149; ENSPTRG00000008327; ENSRBIG00000018408; ENSRROG00000025423; ENSSBOG00000025975","Lysosome; Human immunodeficiency virus 1 infection","MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression","",7675.1,7798.9,7633.2,7224.4,6492.4,4606,1.2611172964830706,0.3347024669305896,0.11087435392676995,0.9551688978195743,0.3404960726263704,0.46788789299211325,2380]
["O43752","Syntaxin-6 [OS=Homo sapiens]",49,6,22,6,255,29.2,4.93,71.86,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","STX6","ENSG00000135823","SNARE interactions in vesicular transport","Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network","",1403,1417.2,1421.2,1251.7,1374.4,1315.7,1.0760058856360037,0.10568596930220636,0.04956617040314019,1.304814634393876,0.22871157795236843,0.6407118497633777,1584]
["O43760","Synaptogyrin-2 [OS=Homo sapiens]",42,6,64,6,224,24.8,4.94,159.97,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","SYNGR2","ENSG00000108639","","","",5232.2,5266.6,5196.5,4717.2,4866.4,5040.2,1.0732709692419207,0.10201435999822127,0.0201223647922931,1.6963209820707028,0.14692743683004023,0.8328970976660486,1001]
["O43765","Small glutamine-rich tetratricopeptide repeat-containing protein alpha [OS=Homo sapiens]",39,11,76,11,313,34,4.87,190.79,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","SGTA","ENSG00000104969","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",9168.7,9415.6,8786.8,8752.8,9262,6439.7,1.1192663926884623,0.16255344799545776,0.334847736962597,0.47515263185689716,0.5473947907536617,0.261699339840956,4471]
["O43766-1","Lipoyl synthase, mitochondrial [OS=Homo sapiens]",4,2,2,2,372,41.9,8.59,4.94,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","mitochondrion","other molecular function","LIAS","ENSG00000121897","Lipoic acid metabolism; Metabolic pathways; Biosynthesis of cofactors","Glyoxylate metabolism and glycine degradation","",231.8,235.9,224.9,257.9,268.6,164.8,1.0018805149717924,2.7104618900486684E-3,0.990186837524105,0.004282851008617731,0.9937217623868849,0.002735199078915202,7283]
["O43768","alpha-endosulfine [OS=Homo sapiens]",17,2,3,2,121,13.4,7.24,9.83,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","ENSA","ENSG00000143420","","MASTL Facilitates Mitotic Progression","",246,201.5,250.5,254.7,241.2,118.2,1.1366226998860118,0.1847534333524475,0.5772628716721364,0.23862637450631152,0.7048470312481866,0.15190512512651116,5986]
["O43772","mitochondrial carnitine/acylcarnitine carrier protein [OS=Homo sapiens]",49,14,46,14,301,32.9,9.41,134.56,"transport;developmental processes","other membranes;cytosol;mitochondrion","transporter activity","SLC25A20","ENSG00000178537","Thermogenesis","Carnitine metabolism","Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation; Thermogenesis",7648.7,7781.7,7620.4,7116.8,6572.5,5849.2,1.1797630319625354,0.23849710793916043,0.03418268324142996,1.4661938494207691,0.19263009391797345,0.7152758636208763,1297]
["O43776","Asparagine--tRNA ligase, cytoplasmic [OS=Homo sapiens]",44,27,177,26,548,62.9,6.25,523.97,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","NARS1","ENSG00000134440","Aminoacyl-tRNA biosynthesis","Cytosolic tRNA aminoacylation","Photodynamic therapy-induced unfolded protein response",20909.8,20797.9,20721.3,21624.7,21700,21522.9,0.96270332286777,-0.0548368249302189,4.2515869662608117E-4,3.371448932997899,0.024662578679682755,1.6079615162314886,126]
["O43791","Speckle-type POZ protein [OS=Homo sapiens]",3,1,1,1,374,42.1,5.8,3.23,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","SPOP","ENSG00000121067","Hedgehog signaling pathway","Hedgehog 'on' state","mRNA processing; Hedgehog signaling pathway",47.6,46.6,43.2,101,83.8,49.2,0.5871794871794872,-0.7681265256526668,0.10296081557450236,0.9873280259511531,0.3313697054311043,0.47968719828691536,2271]
["O43795","Unconventional myosin-Ib [OS=Homo sapiens]",7,7,9,7,1136,131.9,9.38,22.07,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","MYO1B","ENSG00000128641","Pathogenic Escherichia coli infection","","",646.5,628.5,663.5,595,555.3,855.9,0.966254610706809,-0.04952470168120683,0.8235837699477518,0.08429222044592485,0.8795402943524427,0.05574425943101457,6844]
["O43808","peroxisomal membrane protein PMP34 [OS=Homo sapiens]",8,3,6,3,307,34.5,10.08,14.39,"other metabolic processes;transport","other membranes;cytosol;other cytoplasmic organelle","transporter activity;other molecular function","SLC25A17","ENSG00000100372","Peroxisome","Class I peroxisomal membrane protein import; Alpha-oxidation of phytanate","",801.8,809.4,818.2,790.2,800.9,428.8,1.2027328085548787,0.2663161781855664,0.3271776101184512,0.48521642423884426,0.5437337772523329,0.26461368737964286,4398]
["O43809","Cleavage and polyadenylation specificity factor subunit 5 [OS=Homo sapiens]",60,13,65,13,227,26.2,8.82,198.22,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","NUDT21","ENSG00000167005","mRNA surveillance pathway","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs","mRNA processing",9106.2,9180.9,9186.5,8855,9240.8,9662.8,0.9897329116021701,-0.014888841507598173,0.7063579493845564,0.15097516290420018,0.7929304641455572,0.10076489636712388,6511]
["O43813","LanC-like protein 1 [OS=Homo sapiens]",23,8,19,8,399,45.3,7.75,56.37,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","LANCL1","ENSG00000115365","Glutathione metabolism; Metabolic pathways","","",1636.4,1639.4,1628.2,1518.3,1540.6,1446.6,1.088447453112862,0.12227176033882128,0.009646882527983812,2.0156130099342224,0.10263328150951045,0.9887117851097997,687]
["O43815","striatin [OS=Homo sapiens]",31,19,52,19,780,86.1,5.27,148.03,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","STRN","ENSG00000115808","","Extra-nuclear estrogen signaling; PIP3 activates AKT signaling; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins","",4705,4723.4,4756.1,5585.3,5696.3,6241.7,0.8094651121649462,-0.3049591929775149,0.005428040046393014,2.2653569569107255,0.08096641775323785,1.091695075055266,490]
["O43818","U3 small nucleolar RNA-interacting protein 2 [OS=Homo sapiens]",34,14,42,14,475,51.8,7.85,119.52,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","RRP9","ENSG00000114767","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",5162,5219,5209.3,5294.4,4605.5,7108.3,0.9166343293235026,-0.12558177708116178,0.5611067874583129,0.2509544777983027,0.693343957655589,0.15905126487827892,5915]
["O43819","Protein SCO2 homolog, mitochondrial [OS=Homo sapiens]",41,9,41,9,266,29.8,8.85,136.52,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","other membranes;cytoskeleton;mitochondrion","other molecular function","SCO2","ENSG00000284194","Central carbon metabolism in cancer","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","",2930.7,2938.2,3026.3,2897.6,2781.2,3879.4,0.9306354752986967,-0.10371191202386545,0.5616619888560611,0.25052496652558676,0.693092601139448,0.1592087372825573,5923]
["O43823","A-kinase anchor protein 8 [OS=Homo sapiens]",30,12,37,12,692,76.1,5.15,125.45,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","mitochondrion;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","AKAP8","ENSG00000105127","","","G protein signaling pathways",3111.7,3049.1,2851.8,3875.2,4080.6,2723.5,0.8439317183710542,-0.24480181817351482,0.2654883073567721,0.5759546013706662,0.5028385691813028,0.2985714180580899,3859]
["O43824","Putative GTP-binding protein 6 [OS=Homo sapiens]",11,5,7,5,516,56.8,9.42,21.19,"","","","","","","","",584.1,586.2,671.7,715.5,642.9,1442.4,0.6576692373607542,-0.6045659054498062,0.2813786901108028,0.5507087964454416,0.515567020812198,0.28771487087130815,3989]
["O43826-1","Glucose-6-phosphate exchanger SLC37A4 [OS=Homo sapiens]",9,3,9,3,429,46.3,8.62,22.03,"other metabolic processes;transport;other biological processes","other membranes;ER/Golgi","transporter activity","SLC37A4","ENSG00000281500","Carbohydrate digestion and absorption","Gluconeogenesis; Glycogen storage disease type Ib (SLC37A4)","",841.8,892.6,904.9,777.8,803.8,690.5,1.1616126050790019,0.21612901373753593,0.03580668108877969,1.446035931756252,0.196332357147705,0.707008119286138,1333]
["O43829","Zinc finger and BTB domain-containing protein 14 [OS=Homo sapiens]",20,5,6,5,449,50.9,6.04,14.2,"developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB14","ENSG00000198081","","","",327.2,321.7,342.8,407,461.2,656,0.650636399422648,-0.6200765596315759,0.07941137412144342,1.1001172889532107,0.28804850295465506,0.540534377546366,2015]
["O43837-1","isocitrate dehydrogenase [NAD] subunit beta, mitochondrial [OS=Homo sapiens]",46,15,78,14,385,42.2,8.46,228.86,"other metabolic processes","mitochondrion","other molecular function","IDH3B","ENSG00000101365","Citrate cycle (TCA cycle); Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids","Citric acid cycle (TCA cycle)","TCA cycle (aka Krebs or citric acid cycle)",12071.5,11935.2,12410.9,10834.9,9659,8646,1.2497503423141463,0.3216399221843515,0.020065505824022757,1.6975498878208477,0.14680558765543777,0.8332574141628569,999]
["O43847-1","Nardilysin [OS=Homo sapiens]",26,26,63,26,1150,131.5,5,183.22,"","","","","","","","",7384.4,7595.5,7429.8,7337.2,6665.7,5638.7,1.1409304740957968,0.19021087950273555,0.13755902741054235,0.8615109034499647,0.3755767393887389,0.42530131275292443,2677]
["O43852","Calumenin [OS=Homo sapiens]",71,22,218,6,315,37.1,4.64,726.76,"","non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","CALU","ENSG00000128595","","Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","NOTCH1 regulation of endothelial cell calcification; VEGFA-VEGFR2 signaling pathway",26767.2,24732.1,19858.3,26480.9,23816.2,18907.5,1.0311106487141029,0.04419915694047226,0.8238448851433813,0.0841545502782947,0.8796906158528814,0.055670040864330556,6845]
["O43852-4","Isoform 4 of Calumenin [OS=Homo sapiens]",59,17,159,1,323,38.1,4.58,498.58,"","","","CALU","","","","",398,363.8,299.7,353.2,365.9,218.7,1.1319044572403498,0.17875218707191953,0.4966427566062667,0.30395589420789226,0.6467062013246399,0.18929297454359167,5613]
["O43861-1","Probable phospholipid-transporting ATPase IIB [OS=Homo sapiens]",9,8,12,8,1147,129.2,7.61,36.53,"cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ATP9B","ENSG00000166377","","Ion transport by P-type ATPases","",1351.2,1342.1,1305.3,1227,1412.9,1309.5,1.0124575884944549,0.01786147525626753,0.7826143957887705,0.106452167738528,0.853623133684543,0.06873382379046984,6701]
["O43865","S-adenosylhomocysteine hydrolase-like protein 1 [OS=Homo sapiens]",29,14,43,7,530,58.9,6.89,134.9,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","nucleic acid binding activity;other molecular function","AHCYL1","ENSG00000168710","Cysteine and methionine metabolism; Metabolic pathways","Role of phospholipids in phagocytosis; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Ion homeostasis; Regulation of insulin secretion; VEGFR2 mediated cell proliferation; PLC beta mediated events; DAG and IP3 signaling; CLEC7A (Dectin-1) induces NFAT activation","Trans-sulfuration and one-carbon metabolism; One-carbon metabolism and related pathways",3565.3,3619.4,3571.3,3186.4,2955.9,2999.9,1.176522062523244,0.23452837470112525,1.7789839845254246E-3,2.749827961676357,0.04925224978369821,1.307573926662215,264]
["O43896","Kinesin-like protein KIF1C [OS=Homo sapiens]",9,10,10,4,1103,122.9,6.9,26.12,"transport;other biological processes","cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","KIF1C","ENSG00000129250","","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",277.3,274.4,287.6,279.9,332.3,632,0.674570004822376,-0.5679599254434113,0.2861877384122386,0.5433489773336818,0.5180153987258672,0.2856573300573294,4038]
["O43903","Growth arrest-specific protein 2 [OS=Homo sapiens]",38,9,25,9,313,34.9,8.47,91.92,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton","cytoskeletal activity;other molecular function","GAS2","ENSG00000148935","","Caspase-mediated cleavage of cytoskeletal proteins","",3032.4,3280.4,3047.1,2971.8,3130.2,2280.9,1.1165467797540232,0.1590436967540614,0.29856946000697193,0.5249546173369323,0.5258419718532429,0.27914475216505197,4150]
["O43913","Origin recognition complex subunit 5 [OS=Homo sapiens]",19,9,17,9,435,50.3,7.74,48.42,"DNA metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ORC5","ENSG00000164815","Cell cycle","CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication","Cell cycle; G1 to S cell cycle control; DNA replication",2119.9,2136.3,2132,1984.5,2112.6,1643.4,1.112829892866475,0.15423307922624277,0.19817738569493443,0.7029459049881814,0.44431856197677166,0.3523055431721475,3260]
["O43920","NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [OS=Homo sapiens]",11,1,2,1,106,12.5,9.14,3.58,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity","NDUFS5","ENSG00000168653","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",58.1,68.4,57.8,60.2,62.7,76.1,0.9261306532663318,-0.11071235980029777,0.46288460377612994,0.334527264251255,0.6224882371664644,0.20586885078959535,5435]
["O43924","Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [OS=Homo sapiens]",25,3,5,3,150,17.4,5.67,16.56,"other biological processes","other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","PDE6D","ENSG00000156973","Purine metabolism; Metabolic pathways","ARL13B-mediated ciliary trafficking of INPP5E; RAS processing","Phosphodiesterases in neuronal function; Joubert syndrome; Ciliopathies",550.2,550.3,522.5,564.2,523.5,529.5,1.003586445708632,0.005164891163638925,0.9079328948125855,0.04194624893438552,0.9412881600262677,0.026277404041811295,7050]
["O43929","origin recognition complex subunit 4 [OS=Homo sapiens]",15,5,11,5,436,50.3,8,26.58,"DNA metabolism;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ORC4","ENSG00000115947","Cell cycle","CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication","Cell cycle; G1 to S cell cycle control; DNA replication",874.9,882.7,858.6,906,876.8,877.7,0.9833489945498965,-0.024224569114935986,0.2834740359084498,0.5474867130605751,0.5169440440256635,0.28655646403579144,4008]
["O43933","Peroxisome biogenesis factor 1 [OS=Homo sapiens]",8,11,16,11,1283,142.8,6.33,44.12,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","PEX1","ENSG00000127980","Peroxisome","Peroxisomal protein import","",1320.1,1312.5,1402.2,1321.8,1363.9,1689.4,0.9222189207103837,-0.11681882977185166,0.3967961096712351,0.4014325944729946,0.57772565051535,0.23827834973404105,5020]
["O43934","UNC93-like protein MFSD11 [OS=Homo sapiens]",4,3,3,3,449,49.2,5.68,7.53,"","other membranes","","MFSD11","ENSG00000092931","","","",431.9,451.5,448.3,381,320.4,537,1.0753391472868217,0.10479173790183914,0.6563453473832321,0.18286758898100122,0.7568993600542827,0.12096186195130995,6338]
["O60216","Double-strand-break repair protein rad21 homolog [OS=Homo sapiens]",52,26,97,26,631,71.6,4.65,350.07,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","RAD21","ENSG00000164754","Cell cycle","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin","Cell cycle; Prion disease pathway; Regulation of sister chromatid separation at the metaphase-anaphase transition; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome",6797.9,6907.6,6837.3,8137,8262,7143.3,0.8725910382587937,-0.1966224379572589,0.0481422434174391,1.317473675566745,0.22642963779798092,0.6450667281476677,1554]
["O60231","Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [OS=Homo sapiens]",23,21,45,21,1041,119.2,6.8,125.94,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","DHX16","ENSG00000204560; ENSG00000206486; ENSG00000226171; ENSG00000231377; ENSG00000233049; ENSG00000233418; ENSG00000233561","Spliceosome","mRNA Splicing - Major Pathway","mRNA processing",5934.8,5882.5,5844.8,6783.3,6634.3,6338.5,0.894007420492911,-0.16164128868694116,0.006354906250660558,2.1968908518953576,0.08633459068044241,1.0638151656777737,538]
["O60232","Sjoegren syndrome/scleroderma autoantigen 1 [OS=Homo sapiens]",27,3,5,3,199,21.5,5.24,24.01,"cell cycle OR cell proliferation;other biological processes","","","ZNRD2","ENSG00000173465","","","",318.2,413.7,312.9,469.7,479.7,702.2,0.6325986921772826,-0.6606375216297464,0.07066277796243449,1.1508092931672178,0.27154271510380323,0.56616184388464,1902]
["O60234","glia maturation factor gamma [OS=Homo sapiens]",45,6,29,5,142,16.8,5.26,95.43,"protein metabolism;other metabolic processes;signal transduction;other biological processes","non-structural extracellular;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function","GMFG","ENSG00000130755","","Neutrophil degranulation","",2660.2,3453.2,2327.9,2702.7,2764.4,2701.4,1.0333965844402275,0.04739402051921884,0.7991603355331908,0.09736607944491635,0.8649582248500061,0.06300486728112584,6753]
["O60237","Protein phosphatase 1 regulatory subunit 12b [OS=Homo sapiens]",13,11,12,10,982,110.3,5.67,29.37,"signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP1R12B","ENSG00000077157","Vascular smooth muscle contraction; Focal adhesion; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Proteoglycans in cancer","RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs","Focal adhesion",577.1,589.3,586.6,706.3,721.5,854.8,0.7679838780338212,-0.3808520695200818,0.020280281309840196,1.6929260251540876,0.14763802399763146,0.8308017760791152,1004]
["O60244","Mediator of RNA polymerase II transcription subunit 14 [OS=Homo sapiens]",6,7,13,6,1454,160.5,8.73,34.12,"other biological processes","nucleus","other molecular function","MED14","ENSG00000180182","Thyroid hormone signaling pathway","Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","Vitamin D in inflammatory diseases",787.8,814.5,780,763.9,785.9,1622.8,0.7508983168379247,-0.41331053698241776,0.4044646995116289,0.39311937634170263,0.5836589316348461,0.23384086415402894,5065]
["O60256-1","Phosphoribosyl pyrophosphate synthase-associated protein 2 [OS=Homo sapiens]",34,10,27,9,369,40.9,7.44,112.72,"other metabolic processes;other biological processes","other cell component","enzyme regulator activity;other molecular function","PRPSAP2","ENSG00000141127","","","",2754.9,2757.9,2866.1,2837.7,2664.5,2649.7,1.0278462689679708,0.03962450229188004,0.344004296649416,0.46343613301138076,0.5518716866133849,0.25816188653447053,4556]
["O60264","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 [OS=Homo sapiens]",39,40,133,40,1052,121.8,8.09,366.57,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMARCA5","ENSG00000153147","","Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; NoRC negatively regulates rRNA expression","",14059.5,14030.9,13727.1,15770,16147.3,21682.8,0.7801757832541356,-0.35812887724955983,0.10945622737574577,0.9607595247494377,0.3381299940360633,0.4709163031573763,2366]
["O60266","Adenylate cyclase type 3 [OS=Homo sapiens]",4,4,8,4,1144,128.9,6.58,20.91,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","ADCY3","ENSG00000138031","Purine metabolism; Metabolic pathways; Endocrine resistance; Rap1 signaling pathway; Calcium signaling pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Phospholipase D signaling pathway; Oocyte meiosis; Longevity regulating pathway; Longevity regulating pathway; Adrenergic signaling in cardiomyocytes; Vascular smooth muscle contraction; Apelin signaling pathway; Gap junction; Platelet activation; Circadian entrainment; Thermogenesis; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; GABAergic synapse; Olfactory transduction; Inflammatory mediator regulation of TRP channels; Insulin secretion; GnRH signaling pathway; Ovarian steroidogenesis; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Melanogenesis; Thyroid hormone synthesis; Oxytocin signaling pathway; Regulation of lipolysis in adipocytes; Aldosterone synthesis and secretion; Relaxin signaling pathway; Cortisol synthesis and secretion; Parathyroid hormone synthesis, secretion and action; Cushing syndrome; Growth hormone synthesis, secretion and action; Vasopressin-regulated water reabsorption; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Bile secretion; Morphine addiction; Vibrio cholerae infection; Human cytomegalovirus infection; Human T-cell leukemia virus 1 infection; Pathways in cancer; Chemical carcinogenesis; Dilated cardiomyopathy","FCGR3A-mediated IL10 synthesis; Olfactory Signaling Pathway; G alpha (i) signalling events; G alpha (z) signalling events; Adenylate cyclase inhibitory pathway; ADORA2B mediated anti-inflammatory cytokines production; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Adenylate cyclase activating pathway; Hedgehog 'off' state","Thyroid stimulating hormone (TSH) signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; Phosphodiesterases in neuronal function; Thermogenesis; Envelope proteins and their potential roles in EDMD physiopathology; Neuroinflammation and glutamatergic signaling; Calcium regulation in cardiac cells",317.7,333.1,324.9,265.4,307.7,350.7,1.0561809915566138,0.07885708208932414,0.5273668157884591,0.2778872013787108,0.6690720459291526,0.17452711472126448,5761]
["O60268-1","Uncharacterized protein KIAA0513 [OS=Homo sapiens]",9,3,3,3,411,46.6,5.06,9.16,"","other cell component","","KIAA0513","ENSG00000135709","","","",309.7,314.6,326.2,319.6,341.4,249,1.0445054945054946,0.06282008156249352,0.6583639199943883,0.18153397757813208,0.7580311737931607,0.1203129337769697,6348]
["O60271","C-jun-amino-terminal kinase-interacting protein 4 [OS=Homo sapiens]",33,37,102,2,1321,146.1,5.15,305,"transport;other biological processes","other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","SPAG9","ENSG00000008294","","Myogenesis","",9860,9773.8,9683.5,10545.3,10468.9,9689.2,0.9548551626204265,-0.06664618060413013,0.1721271561140427,0.7641506066039155,0.41411368796495657,0.38288041424671015,3038]
["O60271-2","Isoform 2 of C-Jun-amino-terminal kinase-interacting protein 4 [OS=Homo sapiens]",32,36,103,1,1311,145,5.19,309.2,"","","","SPAG9","","","","",368.1,349.4,344.4,387.6,387.5,124.8,1.1800200022224694,0.2388113145554108,0.5721324241630752,0.24250343899175938,0.7008070870132255,0.15440151495188445,5967]
["O60281-1","zinc finger protein 292 [OS=Homo sapiens]",2,5,5,5,2723,304.6,7.39,7.84,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF292","ENSG00000188994","","","",79.2,82.2,90.2,107.8,100.7,461,0.3758028379387603,-1.4119521333323837,0.30667314050602323,0.513324259364216,0.5304008480734793,0.2753957901965377,4226]
["O60285","NUAK family SNF1-like kinase 1 [OS=Homo sapiens]",2,1,1,1,661,74.3,8.82,2.03,"cell adhesion;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","NUAK1","ENSG00000074590","","Regulation of TP53 Activity through Phosphorylation","",51.6,54.3,62.5,82.8,80.8,156,0.5269086357947433,-0.924375269861581,0.11355753584944689,0.9447840400507137,0.34368199980273595,0.46384321325427164,2415]
["O60287","nucleolar pre-ribosomal-associated protein 1 [OS=Homo sapiens]",8,14,26,14,2271,254.2,6.47,81.68,"RNA metabolism OR transcription;other metabolic processes","nucleus","","URB1","ENSG00000142207","","","",2667.5,2935.9,2875.3,3446.5,3317.7,10983.1,0.47774591064556304,-1.065684570646674,0.2899384074921721,0.5376942508158428,0.5192746435580214,0.28460288370514075,4081]
["O60291-1","E3 ubiquitin-protein ligase MGRN1 [OS=Homo sapiens]",6,2,2,2,552,60.7,5.15,7.27,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MGRN1","ENSG00000102858","Ubiquitin mediated proteolysis; Hedgehog signaling pathway","Antigen processing: Ubiquitination & Proteasome degradation","",115.3,131.5,125.5,130,115.8,163.8,0.9089355468750001,-0.13775009914848702,0.4537920512349115,0.34314311562395583,0.6169579803712738,0.20974441378575176,5376]
["O60292","Signal-induced proliferation-associated 1-like protein 3 [OS=Homo sapiens]",1,1,1,1,1781,194.5,8.32,2.87,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","enzyme regulator activity","SIPA1L3","ENSG00000105738","Rap1 signaling pathway","","",27.1,20.4,24,21.3,21.1,16.5,1.2139219015280134,0.27967560783529083,0.1670737394248092,0.777091806953721,0.40909278440734687,0.388178180535136,2985]
["O60293","Zinc finger C3H1 domain-containing protein [OS=Homo sapiens]",8,11,13,11,1989,226.2,8.13,35.99,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","other molecular function","ZFC3H1","ENSG00000133858","","","",558.2,588.5,539.7,830.6,884.6,868.4,0.6527326211487847,-0.6154359532511752,1.5228314657136856E-4,3.817348158095758,0.017123654127540505,1.7664035528546405,65]
["O60294","tRNA wybutosine-synthesizing protein 4 [OS=Homo sapiens]",5,3,3,3,686,75.6,6.73,3.98,"RNA metabolism OR transcription;other metabolic processes","other cell component","other molecular function","LCMT2","ENSG00000168806","","Synthesis of wybutosine at G37 of tRNA(Phe)","",335,339,369.6,354.7,347.9,191.8,1.166815742397138,0.2225767559742622,0.41164798506338973,0.3854740060340541,0.5878732166526603,0.23071632570124775,5118]
["O60306","Intron-binding protein aquarius [OS=Homo sapiens]",14,20,39,19,1485,171.2,6.37,107.07,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","AQR","ENSG00000021776","Spliceosome","mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER","",3755.8,3876.8,3703.9,4478,4610.9,4476.3,0.8357045970571757,-0.2589350230043194,3.9659467039065944E-4,3.4016531263270844,0.02375992168758467,1.6241549951178598,122]
["O60307","Microtubule-associated serine/threonine-protein kinase 3 [OS=Homo sapiens]",3,4,6,2,1309,143,8.06,12.05,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction","","kinase activity;other molecular function","MAST3","ENSG00000099308","","","",142.9,141.7,154.4,205.7,198.1,274.2,0.6474926253687316,-0.6270643336009856,0.031466609779661266,1.502150045561473,0.18413887180107621,0.7348545220516354,1249]
["O60308","Centrosomal protein of 104 kDa [OS=Homo sapiens]",2,2,3,2,925,104.4,7.62,7.45,"","cytoskeleton;other cell component","other molecular function","CEP104","ENSG00000116198","","","Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies",300.6,299.1,344.8,293,235.7,337.8,1.0900173110213502,0.12435104722820005,0.47647621326467143,0.32195877541547785,0.6321591291979458,0.19917358590482626,5509]
["O60313-2","Isoform 2 of Dynamin-like 120 kDa protein, mitochondrial [OS=Homo sapiens]",41,39,101,39,997,115.8,7.87,303.65,"","","","OPA1","","","","",12660.9,12761.6,12894.6,12934.5,12496.6,10329.4,{"$f":"AVERAGE(S450:U450)/AVERAGE(V450:X450)","v":1.0714922889780625},{"$f":"LOG(Y450,2)","v":0.09962146765968799},{"$f":"TTEST(V450:X450,S450:U450,2,2)","v":0.3511614606457986},0.45449315320808736,{"$f":"AA450*7309/AE450","v":0.555429369370297},0.2553711598428194,4621]
["O60318","Germinal-center associated nuclear protein [OS=Homo sapiens]",12,13,21,13,1980,218.3,6.39,81.22,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","MCM3AP","ENSG00000160294","","","",1230.2,1162.3,1240.2,1281.1,1266.5,1720,0.8512278564064109,-0.2323827311232148,0.23313958554316694,{"$f":"-LOG10(AA451)","v":0.6323839799184923},0.47973458072494574,{"$f":"-LOG10(AC451)","v":0.3189989751410827},3552]
["O60331","Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [OS=Homo sapiens]",9,6,10,5,668,73.2,5.29,22.5,"cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","PIP5K1C","ENSG00000186111","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Phospholipase D signaling pathway; Endocytosis; Focal adhesion; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Yersinia infection; Choline metabolism in cancer","Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion","B cell receptor signaling pathway; Focal adhesion; Regulation of actin cytoskeleton",955.3,968.8,958.1,882.3,877.3,1325.8,0.9341414403318857,-0.09828708690489434,0.6724395851698057,0.1723467284348513,0.7681870784629744,0.11453300229896657,6398]
["O60333","Kinesin-like protein KIF1B [OS=Homo sapiens]",15,21,28,9,1816,204.3,5.6,85.55,"cell-cell signaling;transport;other biological processes","other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","KIF1B","ENSG00000054523","","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","Intracellular trafficking proteins involved in CMT neuropathy",2111.8,2173.5,2225.8,2461.7,2460.7,3108.3,0.8107761465376617,-0.30262445030806456,0.0810123217479894,1.0914489211191012,0.29053928344261754,0.5367951389055359,2038]
["O60333-3","Isoform 3 of Kinesin-like protein KIF1B [OS=Homo sapiens]",13,13,18,1,1153,130.3,8.43,47.74,"","","","KIF1B","","","","",36.1,43.3,37.5,47,43.7,28.9,0.9774247491638797,-0.0329424596664486,0.8877648469496187,0.05170205583921704,0.9280139110919283,0.032445513581590694,6992]
["O60337","E3 ubiquitin-protein ligase MARCH6 [OS=Homo sapiens]",2,2,2,2,910,102.5,6.28,5.33,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","other molecular function","MARCHF6","ENSG00000145495","Protein processing in endoplasmic reticulum","ER Quality Control Compartment (ERQC)","",202.8,184.6,227.3,282.2,288.9,535.9,0.5552845528455285,-0.8487008319365117,0.12371082906293945,0.907592282614748,0.3575335902020658,0.4466831500751798,2529]
["O60341","Lysine-specific histone demethylase 1A [OS=Homo sapiens]",20,13,20,13,852,92.8,6.52,66.77,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KDM1A","ENSG00000004487","Thermogenesis","Estrogen-dependent gene expression; Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; Factors involved in megakaryocyte development and platelet production; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3","Androgen receptor signaling pathway; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; Thermogenesis; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects",1847.4,1820.7,1922.2,2261.8,2179,2059,0.8600726176190038,-0.2174696203564258,0.010211453331691432,1.990912443122068,0.1057160232313494,0.9758591822898988,706]
["O60343-1","TBC1 domain family member 4 [OS=Homo sapiens]",1,1,1,1,1298,146.5,7.01,0,"transport;other biological processes","cytosol;other cell component","enzyme regulator activity","TBC1D4","ENSG00000136111","Thyroid hormone signaling pathway; Insulin resistance; Diabetic cardiomyopathy","Translocation of SLC2A4 (GLUT4) to the plasma membrane","Ciliary landscape; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling",29.7,23.7,28.6,23.3,23.9,18.5,1.248097412480974,0.3197305391831164,0.09677256954646282,1.0142477272248638,0.3199053418431012,0.4949785079196048,2211]
["O60344-1","Endothelin-converting enzyme 2 [OS=Homo sapiens]",5,4,10,4,883,99.7,5.1,26.93,"protein metabolism;other metabolic processes;developmental processes","plasma membrane;other membranes;ER/Golgi","other molecular function","EEF1AKMT4-ECE2","ENSG00000284917","","","",1228.3,1226.1,1340.3,1393.1,1286.6,2842.5,0.6871717793632972,-0.5412573055131731,0.31633950441749425,0.4998465700848128,0.5373287096880004,0.26975995428339533,4303]
["O60353-1","Frizzled-6 [OS=Homo sapiens]",6,3,3,3,706,79.2,7.96,6.58,"cell-cell signaling;cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","FZD6","ENSG00000164930","mTOR signaling pathway; Wnt signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Proteoglycans in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer","Class B/2 (Secretin family receptors); Ca2+ pathway; PCP/CE pathway; Regulation of FZD by ubiquitination; Signaling by RNF43 mutants","Alzheimer's disease and miRNA effects; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Osteoblast differentiation and related diseases; Malignant pleural mesothelioma; Alzheimer's disease",81.9,90.9,85.8,115.1,126.5,246.4,0.5299180327868853,-0.9161588726399942,0.1433223795022407,0.8436859900948592,0.3812020639672042,0.4188447565983991,2748]
["O60361","putative nucleoside diphosphate kinase [OS=Homo sapiens]",66,8,139,1,137,15.5,8.57,432.69,"other metabolic processes;other biological processes","","kinase activity;other molecular function","NME2P1","","","Interconversion of nucleotide di- and triphosphates","",953.4,852.2,913.2,692.4,652.8,165.6,1.7995763833730478,0.847657339036624,0.07919205561790436,1.101318383743322,0.28839797434542247,0.5400077943468347,2007]
["O60381-1","HMG box-containing protein 1 [OS=Homo sapiens]",5,2,2,2,514,57.6,6.19,7.78,"cell-cell signaling;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HBP1","ENSG00000105856; ENSG00000283847; ENSPPAG00000042116; ENSPTRG00000019575","","","",154.3,162.4,167.4,154.4,152.8,222,0.9147770219198791,-0.12850796741782097,0.5510312111577698,0.2588238014209847,0.685879959528634,0.1637518864450259,5872]
["O60427","Fatty acid desaturase 1 [OS=Homo sapiens]",2,1,1,1,444,51.9,8.87,2.12,"cell-cell signaling;other metabolic processes;stress response;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","FADS1","ENSG00000149485","Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism","PPARA activates gene expression; alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Linoleic acid metabolism affected by coronavirus infection",265.3,268.6,233.1,367,389,419.4,0.6525438148715332,-0.6158533205984471,0.001987767907484192,2.701634325362848,0.05115702688662662,1.2910947035259128,284]
["O60447","Ecotropic viral integration site 5 protein homolog [OS=Homo sapiens]",3,2,2,2,810,92.9,6.1,6.74,"cell cycle OR cell proliferation;transport;other biological processes","cytosol;cytoskeleton;nucleus","enzyme regulator activity;other molecular function","EVI5","ENSG00000067208","","","",82.2,78.7,77.5,96.1,89.2,93.6,0.8547866618859807,-0.22636369856615035,0.005377304141707138,2.2694353990204412,0.0808697859500771,1.0922137063987618,486]
["O60449","Lymphocyte antigen 75 [OS=Homo sapiens]",7,11,15,11,1722,198.2,6.67,42.58,"stress response;transport;other biological processes","plasma membrane;other membranes","other molecular function","LY75","ENSG00000054219","","","",1565.7,1503.5,1544.2,1687.8,1741.2,1922.4,0.86209216279852,-0.21408598461606695,0.028407183624519407,1.546571821432324,0.1752135908114872,0.7564322098944737,1185]
["O60476","mannosyl-oligosaccharide 1,2-alpha-mannosidase IB [OS=Homo sapiens]",7,4,10,4,641,73,7.61,26.26,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","MAN1A2","ENSG00000198162","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum","Intra-Golgi traffic; Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2","",764.8,754.5,811.8,758.6,743.5,1118.5,0.8895291154697398,-0.16888626729671055,0.4793156450805298,0.3193783952075594,0.6333968631158186,0.19832409179275198,5531]
["O60486","Plexin-C1 [OS=Homo sapiens]",24,30,84,29,1568,175.6,7.61,247.2,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","PLXNC1","ENSG00000136040","Axon guidance","Other semaphorin interactions","",8427.6,8500.5,8708,7173.7,7596.6,6837.2,1.1864445215781558,0.24664464135331068,0.004653740936401052,2.3321977966021503,0.07492112886377818,1.1253956875752813,454]
["O60488-1","Long-chain-fatty-acid--CoA ligase 4 [OS=Homo sapiens]",42,23,70,20,711,79.1,8.38,174.26,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ACSL4","ENSG00000068366","Fatty acid biosynthesis; Fatty acid degradation; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; Peroxisome; Ferroptosis; Thermogenesis; Adipocytokine signaling pathway","Synthesis of very long-chain fatty acyl-CoAs; Intracellular metabolism of fatty acids regulates insulin secretion","Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters",8791.2,9067.3,8481.2,8245.1,8046.9,7127.4,1.1246957650494889,0.16953479911908087,0.06418100249754027,1.1925935035734914,0.255639753272219,0.5923716102776264,1835]
["O60493-1","sorting nexin-3 [OS=Homo sapiens]",15,2,3,2,162,18.8,8.66,9.39,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","LOC111158258; Snx3; SNX3; Snx3_1","ENSAMEG00000008145; ENSANAG00000028701; ENSBIXG00000016466; ENSBIXG00005007963; ENSBMUG00000010256; ENSBTAG00000018801; ENSCANG00000036155; ENSCATG00000029122; ENSCCAG00000022069; ENSCGRG00015001325; ENSCHIG00000003391; ENSCJAG00000005955; ENSCSAG00000015156; ENSDLEG00000017815; ENSFCAG00000024997; ENSG00000112335; ENSLCNG00005012116; ENSMFAG00000039300; ENSMMNG00015010894; ENSMMUG00000020366; ENSMNEG00000027766; ENSMPUG00000009812; ENSMUSG00000019804; ENSNVIG00000004406; ENSOARG00000010805; ENSPANG00000017995; ENSPCOG00000020531; ENSPCTG00005013214; ENSPPAG00000032382; ENSPPYG00000016894; ENSPTRG00000018473; ENSPTRG00000046352; ENSRFEG00010011106; ENSRROG00000037899; ENSSBOG00000028606; ENSSSCG00000004385; ENSSSCG00070023370; ENSSSUG00005019212; ENSSTOG00000007274; ENSTSYG00000035289; ENSTTRG00000008868; ENSUAMG00000027552","Endocytosis","Ub-specific processing proteases; WNT ligand biogenesis and trafficking; Ub-specific processing proteases; WNT ligand biogenesis and trafficking; WNT ligand biogenesis and trafficking; Ub-specific processing proteases; WNT ligand biogenesis and trafficking","",361.8,515.8,327.2,470.7,471.2,662.4,0.7509817365829333,-0.41315027218326056,0.1973243592527118,0.7048192987517284,0.4441773149917063,0.35244362549375696,3247]
["O60496","Docking protein 2 [OS=Homo sapiens]",43,11,20,11,412,45.4,6.02,62.11,"signal transduction","cytosol","signal transduction activity or receptor binding","DOK2","ENSG00000147443","","RET signaling; Tie2 Signaling","RAC1/PAK1/p38/MMP2 pathway; IL-4 signaling pathway; EGF/EGFR signaling pathway",1613.9,1593.4,1650.4,1788.8,1798.2,2269.3,0.8294827792292062,-0.269716064976287,0.10518895702123911,0.9780298510232814,0.3348545674513226,0.4751437728652444,2296]
["O60499","Syntaxin-10 [OS=Homo sapiens]",19,2,3,2,249,28.1,4.89,9.32,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","STX10","ENSG00000104915","Salmonella infection","Retrograde transport at the Trans-Golgi-Network","",24.8,24.8,23.8,21.3,24.2,23.3,1.0668604651162792,0.09337149814111499,0.1707418460712385,0.7676600272705724,0.41268259025617793,0.3843838522157684,3024]
["O60502","protein O-GlcNAcase [OS=Homo sapiens]",33,27,59,27,916,102.8,4.91,160.99,"protein metabolism;other metabolic processes","cytosol;nucleus","other molecular function","OGA","ENSG00000198408","Insulin resistance","","",6440.5,6453.4,6529.9,8554.2,8713.5,6651.8,0.8120487468383536,-0.30036176068987963,0.08661073668079401,1.0624282674261367,0.30202188664118484,0.5199615838538529,2096]
["O60506","Heterogeneous nuclear ribonucleoprotein Q [OS=Homo sapiens]",58,32,270,2,623,69.6,8.59,831.37,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity","SYNCRIP","ENSG00000135316","","","",15586.9,15296,15649.5,18221.6,17923,15128.9,0.9075331311496192,-0.13997778260788332,0.18597304783186927,0.7305499914059587,0.43001487080137063,0.3665165253615654,3161]
["O60506-3","Isoform 3 of Heterogeneous nuclear ribonucleoprotein Q [OS=Homo sapiens]",56,29,255,1,562,62.6,7.56,769.42,"","","","SYNCRIP","","","","",357.6,395.4,417.2,565.7,581.9,1295,0.4790796692049456,-1.061662504041897,0.1533345566086137,0.8143599583016647,0.39268474921245883,0.40595596519632,2854]
["O60508","pre-mRNA-processing factor 17 [OS=Homo sapiens]",21,10,17,10,579,65.5,7.06,44.75,"RNA metabolism OR transcription;other metabolic processes","nucleus","","CDC40","ENSG00000168438","Spliceosome","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway","mRNA processing",1343.4,1355.1,1324.6,1884.7,2035.2,1401.4,0.7560370586134967,-0.4034711422299494,0.08658598149024857,1.0625524157684274,0.302223943988647,0.519671131227278,2094]
["O60512","beta-1,4-galactosyltransferase 3 [OS=Homo sapiens]",22,6,13,6,393,43.9,9.25,41.19,"protein metabolism;other metabolic processes","other membranes;cytosol;ER/Golgi","other molecular function","B4GALT3","ENSG00000158850","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Other types of O-glycan biosynthesis; Mannose type O-glycan biosynthesis; Glycosaminoglycan biosynthesis; Glycosphingolipid biosynthesis; Metabolic pathways","N-Glycan antennae elongation; Keratan sulfate biosynthesis","",480.8,472.1,405.9,592,681.3,877.6,0.6317355525593938,-0.6626073289729526,0.03939867512086593,1.4045183821686247,0.20613093518855335,0.6858568263988337,1397]
["O60518","ran-binding protein 6 [OS=Homo sapiens]",7,6,30,3,1105,124.6,5.01,74.1,"transport","nucleus;other cell component","other molecular function","RANBP6","ENSG00000137040","","","",167,183.4,187.5,196.5,195.8,258,0.8271566969091189,-0.2737674348507261,0.1570648775487486,0.8039209199384824,0.39654134369734145,0.40171152611796435,2895]
["O60524","nuclear export mediator factor NEMF [OS=Homo sapiens]",16,16,29,16,1076,122.9,6.35,83.71,"protein metabolism;other metabolic processes;transport","nucleus;other cell component","translation activity;nucleic acid binding activity","NEMF","ENSG00000165525","","","",3549.9,3718.1,3523.7,3779.2,3725.1,3271.4,1.001484822331728,2.1405570341236683E-3,0.976768205965554,0.01020848522046436,0.9851247160759258,0.006508784654769661,7247]
["O60547-1","GDP-mannose 4,6 dehydratase [OS=Homo sapiens]",32,11,32,11,372,41.9,7.31,83.54,"other metabolic processes;signal transduction","cytosol;other cell component","other molecular function","GMDS","ENSG00000112699; ENSPPAG00000026874; ENSPPYG00000016168; ENSPTRG00000017663","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars","GDP-fucose biosynthesis","",4170.7,4009.6,4161.6,3581.9,3324.7,3696.9,1.1639458669307303,0.21902396260475004,8.922296356601668E-3,2.049523355640552,0.09925884942222464,1.0032307633163597,657]
["O60551","Glycylpeptide N-tetradecanoyltransferase 2 [OS=Homo sapiens]",20,8,34,4,498,56.9,7.58,109.02,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","NMT2","ENSG00000152465","","Membrane binding and targetting of GAG proteins; Inactivation, recovery and regulation of the phototransduction cascade","",371.7,375.2,414.7,414.8,367.4,2429.6,0.3616663553147767,-1.4672687000403997,0.3716192592040434,0.42990178674163243,0.5630524804150815,0.24945112398975436,4824]
["O60563","Cyclin-T1 [OS=Homo sapiens]",18,11,17,11,726,80.6,8.78,48.91,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","CCNT1","ENSG00000129315","Transcriptional misregulation in cancer","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interactions of Tat with host cellular proteins","Initiation of transcription and translation elongation at the HIV-1 LTR; Male infertility",1662.7,1579.1,1748.9,1881.5,1950,1825.1,0.8822791075911325,-0.18069297262006534,0.021854305424398222,1.6604629917432878,0.15300107121353124,0.8153055285255583,1044]
["O60566","Mitotic checkpoint serine/threonine-protein kinase BUB1 beta [OS=Homo sapiens]",20,18,29,18,1050,119.5,5.27,70.87,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","BUB1B","ENSG00000156970","Cell cycle; Human T-cell leukemia virus 1 infection","Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A","Regulation of sister chromatid separation at the metaphase-anaphase transition",2749,2771.9,2758,3456.6,3177.8,3709.4,0.8003731704015933,-0.3212552879352095,0.010996479269331305,1.9587463401736034,0.10994974963001711,0.958805755247491,731]
["O60568","Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 [OS=Homo sapiens]",28,18,49,18,738,84.7,6.05,140.33,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;other membranes;ER/Golgi","other molecular function","PLOD3","ENSG00000106397","Lysine degradation; Other types of O-glycan biosynthesis; Metabolic pathways","Collagen biosynthesis and modifying enzymes","VEGFA-VEGFR2 signaling pathway; IL-18 signaling pathway",5896.3,5658.8,6181.1,5670.6,5357.1,7017.2,0.9828926732761056,-0.024894204451570347,0.8558228064557922,0.06761614437004833,0.905109085861002,0.04329907545504423,6911]
["O60573","eukaryotic translation initiation factor 4E type 2 [OS=Homo sapiens]",27,6,12,6,245,28.3,8.88,35.32,"protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF4E2","ENSG00000135930","EGFR tyrosine kinase inhibitor resistance; HIF-1 signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Longevity regulating pathway; Insulin signaling pathway","ISG15 antiviral mechanism","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; EGFR tyrosine kinase inhibitor resistance",1481.3,1655.7,1519.6,2053.8,2003.7,1392.3,0.8544533744357591,-0.22692632540322596,0.29406467540608494,0.5315571420948118,0.52205943952953,0.2822800472083248,4117]
["O60583-2","Isoform 2 of Cyclin-T2 [OS=Homo sapiens]",4,2,2,2,663,73.6,9.14,4.4,"","","","CCNT2","","","","",25.7,27,35.1,36.3,33,33.6,0.8532555879494654,-0.22895013735861044,0.18098089358798994,0.7423672718009554,0.42451519616001876,0.37210675891750933,3116]
["O60610-1","Protein diaphanous homolog 1 [OS=Homo sapiens]",51,64,287,62,1272,141.3,5.41,788.76,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","DIAPH1","ENSG00000131504","Focal adhesion; Regulation of actin cytoskeleton; AGE-RAGE signaling pathway in diabetic complications; Shigellosis","RHOA GTPase cycle; RHOC GTPase cycle; RHO GTPases Activate Formins; RHOB GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; ERBB2 Regulates Cell Motility","Microtubule cytoskeleton regulation; AGE/RAGE pathway; Focal adhesion; Type 2 papillary renal cell carcinoma; Regulation of actin cytoskeleton; G13 signaling pathway",30818.4,30473.8,31095.4,30399,29739.8,31001.7,1.0136832692381543,0.01960694496494825,0.3641271260580118,0.4387469666071403,0.56041380592925,0.25149117430518564,4749]
["O60613-1","selenoprotein F [OS=Homo sapiens]",30,4,18,4,162,17.8,5.03,52.18,"","","","","","","","",1852,2153.2,1800.3,1766.6,1898.4,2401,0.9570557204088361,-0.06332517308374097,0.7161234018380637,0.1450121339497803,0.8010630462250393,0.09633330220522597,6534]
["O60637","Tetraspanin-3 [OS=Homo sapiens]",6,2,4,2,253,28,5.81,9.72,"","plasma membrane;other membranes","","TSPAN3","ENSG00000140391","","","",692.7,730.8,724.1,749.3,750.9,1351.9,0.7529890256302374,-0.4092992562640085,0.3074416192525893,0.5122373411685697,0.5309760858027351,0.2749250383117261,4232]
["O60645","exocyst complex component 3 [OS=Homo sapiens]",18,12,32,12,756,86.8,6.11,85.84,"","","","","","","","",3004.9,2936.9,3099.6,3159.2,2964.1,2478.7,1.0510811439200185,0.07187405028212979,0.5196733790904409,0.2842695298776235,0.6635731530000056,0.17811119308138926,5724]
["O60664-1","Perilipin-3 [OS=Homo sapiens]",58,23,80,23,434,47,5.44,261.45,"transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","PLIN3","ENSG00000105355","","RHOBTB3 ATPase cycle; Late endosomal microautophagy; Triglyceride catabolism; Retrograde transport at the Trans-Golgi-Network; Lipophagy; Chaperone Mediated Autophagy","",10252.1,10082.3,10279.8,10852.4,10944.6,10650.6,0.9434965914274092,-0.08391078908035507,0.004573309545628201,2.3397694022911915,0.07428070993110338,1.129123954182562,450]
["O60669","monocarboxylate transporter 2 [OS=Homo sapiens]",5,3,6,3,478,52.2,9.31,15.05,"transport","plasma membrane;other membranes;nucleus","transporter activity","SLC16A7","ENSG00000118596","","Proton-coupled monocarboxylate transport","Male infertility",797.9,781.4,912.2,772.5,884.6,792.5,1.0171048334421946,0.024468386071106785,0.8076138602808591,0.09279623629620223,0.8698570151477748,0.06055212972132817,6786]
["O60671-1","Cell cycle checkpoint protein RAD1 [OS=Homo sapiens]",20,4,10,4,282,31.8,4.83,32.83,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RAD1","ENSCCAG00000029737; ENSG00000113456; ENSGGOG00000004219; ENSMFAG00000012657; ENSMMUG00000045918; ENSPANG00000024799; ENSPPAG00000028406; ENSPPYG00000015389; ENSPTRG00000016783","Cellular senescence","Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA)","miRNA regulation of DNA damage response; ATR signaling; DNA damage response",1016.5,1136.9,964,959.4,843,813.7,1.1916211154007874,0.25292559333091275,0.06939160329063429,1.158693078034559,0.26934850156731066,0.5696854361672508,1883]
["O60674","Tyrosine-protein kinase JAK2 [OS=Homo sapiens]",2,2,2,2,1132,130.6,7.21,5.57,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","JAK2","ENSG00000096968","EGFR tyrosine kinase inhibitor resistance; Chemokine signaling pathway; PI3K-Akt signaling pathway; Necroptosis; Signaling pathways regulating pluripotency of stem cells; JAK-STAT signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; Cholinergic synapse; Prolactin signaling pathway; Adipocytokine signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Leishmaniasis; Toxoplasmosis; Tuberculosis; Hepatitis B; Influenza A; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Pathways in cancer; Chemical carcinogenesis; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis","RMTs methylate histone arginines; Potential therapeutics for SARS; Signaling by BRAF and RAF1 fusions; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Signaling by SCF-KIT; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Interleukin-4 and Interleukin-13 signaling; Cyclin D associated events in G1; Factors involved in megakaryocyte development and platelet production; Growth hormone receptor signaling; Interleukin-6 signaling; Signaling by Leptin; Regulation of IFNG signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; RAF activation; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; Prolactin receptor signaling; IL-6-type cytokine receptor ligand interactions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-12 signaling; Interleukin-23 signaling; Interleukin-27 signaling; Erythropoietin activates Phospholipase C gamma (PLCG); Erythropoietin activates STAT5; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants","IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Mesodermal commitment pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Mesodermal commitment pathway; IL-6 signaling pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; PI3K-Akt signaling pathway; Immune response to tuberculosis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; EGF/EGFR signaling pathway; Overview of interferons-mediated signaling pathway; Gastrin signaling pathway; Hepatitis B infection; EGFR tyrosine kinase inhibitor resistance; mBDNF and proBDNF regulation of GABA neurotransmission; 16p11.2 distal deletion syndrome; CCL18 signaling pathway; EPO receptor signaling; Notch signaling pathway (Netpath); Type II interferon signaling (IFNG); Serotonin receptor 2 and STAT3 signaling",33.5,36.6,29.1,39.7,33.7,33.3,0.9297094657919398,-0.10514815043755006,0.45196383098251547,0.34489631880193605,0.6164216534150412,0.2101221139615749,5359]
["O60678","protein arginine N-methyltransferase 3 [OS=Homo sapiens]",7,3,4,3,531,59.8,5.35,11.5,"","","","","","","","",203,197.2,186.9,186.8,189.4,173.7,1.0676486633933442,0.09443697008691809,0.14074732283108266,0.851559857156869,0.37932233870663096,0.42099158046792173,2712]
["O60683-1","Peroxisome biogenesis factor 10 [OS=Homo sapiens]",11,2,2,2,326,37,9.99,7.37,"cell organization and biogenesis;transport","other membranes;other cytoplasmic organelle","other molecular function","PEX10","ENSG00000157911","Peroxisome","E3 ubiquitin ligases ubiquitinate target proteins; Peroxisomal protein import","Male infertility",256.5,269.6,269.1,233.5,222.1,712.8,0.6805888394385484,-0.5551446012668927,0.48475481074647797,0.3144778722538324,0.6367852105941781,0.19600703168986824,5564]
["O60684","Importin subunit alpha-7 [OS=Homo sapiens]",40,20,64,15,536,60,4.98,212.03,"transport;other biological processes","nucleus;other cell component","other molecular function","KPNA6","ENSG00000025800","Nucleocytoplasmic transport; Influenza A; Chemical carcinogenesis","Assembly of the ORC complex at the origin of replication","",6854.3,6911.9,6854,7048.3,7090.5,5137.5,1.0697177362875656,0.09723016655208296,0.5252010607032696,0.27967440547457706,0.6677151770186462,0.17540875223657895,5749]
["O60701","UDP-glucose 6-dehydrogenase [OS=Homo sapiens]",27,10,21,10,494,55,7.12,73.03,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes","cytosol;nucleus","other molecular function","UGDH","ENSG00000109814","Pentose and glucuronate interconversions; Ascorbate and aldarate metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars","Formation of the active cofactor, UDP-glucuronate","Glucuronidation",1926.1,1991.5,2043.4,2047.8,1980.8,2457.5,0.9190422596013013,-0.12179689353029916,0.31590359428714637,0.5004454327520408,0.536962644335989,0.2700559264476544,4300]
["O60704","Protein-tyrosine sulfotransferase 2 [OS=Homo sapiens]",7,2,2,2,377,41.9,9.09,6.91,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","TPST2","ENSG00000128294","","Cytosolic sulfonation of small molecules; Gamma carboxylation, hypusine formation and arylsulfatase activation; Defective F8 sulfation at Y1699","",247.3,240.5,251,266.2,271.7,232.7,0.9587334544510772,-0.060798319677111724,0.4465183738267848,0.3501606655830404,0.6124231177143873,0.2129484239399792,5329]
["O60711-1","Leupaxin [OS=Homo sapiens]",36,11,87,11,386,43.3,6.01,336.59,"cell adhesion;cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","LPXN","ENSG00000110031","","","",7020.9,6859.6,7202.5,7934.7,7964.5,9958.9,0.8153344599951273,-0.2945361032807218,0.07845163334073697,1.1053980100950835,0.2877084737016791,0.5410473469115982,1993]
["O60725","protein-s-isoprenylcysteine O-methyltransferase [OS=Homo sapiens]",6,2,3,2,284,31.9,7.96,7.07,"protein metabolism;other metabolic processes;transport","other membranes;ER/Golgi","other molecular function","ICMT","ENSG00000116237","Terpenoid backbone biosynthesis","RAS processing; Gamma carboxylation, hypusine formation and arylsulfatase activation","Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome",579.5,553.5,577.2,503.6,502.5,1101.3,0.8115213058745374,-0.3012991227560952,0.543377852758745,0.2648980667290957,0.6806424551522994,0.16708096522651175,5835]
["O60733","85/88 kDa calcium-independent phospholipase A2 [OS=Homo sapiens]",1,1,1,1,806,89.8,7.27,2.59,"other metabolic processes;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component","other molecular function","PLA2G6","ENSG00000184381","Glycerophospholipid metabolism; Ether lipid metabolism; Arachidonic acid metabolism; Linoleic acid metabolism; alpha-Linolenic acid metabolism; Metabolic pathways; Ras signaling pathway; Vascular smooth muscle contraction; Fc gamma R-mediated phagocytosis; Inflammatory mediator regulation of TRP channels","Role of phospholipids in phagocytosis; COPI-independent Golgi-to-ER retrograde traffic; Acyl chain remodelling of PC; Acyl chain remodelling of PE; Acyl chain remodeling of CL","Eicosanoid synthesis; Spinal cord injury; Ras signaling; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Eicosanoid metabolism via cyclooxygenases (COX); Omega-3 / omega-6 fatty acid synthesis",199,190.8,194.7,191.3,201.7,76.9,1.2438816769525431,0.3148492570179031,0.3941891264640985,0.40429535971606756,0.5758801369830293,0.23966790071550378,5003]
["O60749","Sorting nexin-2 [OS=Homo sapiens]",43,20,66,18,519,58.4,5.12,199.82,"cell organization and biogenesis;transport","other membranes;cytosol;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","SNX2","ENSG00000205302","Endocytosis","Golgi Associated Vesicle Biogenesis","",7718.1,7694.4,7836.9,7414.6,7304.2,6584.4,1.0913571669983855,0.1261233278119713,0.06989126041067724,1.155577127440523,0.2702831864241481,0.5681809697297943,1890]
["O60759","cytohesin-interacting protein [OS=Homo sapiens]",12,2,3,2,359,40,6.99,8.96,"other biological processes","cytosol;nucleus;other cytoplasmic organelle;other cell component","","CYTIP","ENSG00000115165","","","Amplification and expansion of oncogenic pathways as metastatic traits",196.7,204.4,202.8,227.7,247.2,187.2,0.9120978704123248,-0.1327394573582737,0.337635930362798,0.4715513430654042,0.5482739424620507,0.26100239411991016,4501]
["O60762","Dolichol-phosphate mannosyltransferase subunit 1 [OS=Homo sapiens]",47,10,50,10,260,29.6,9.57,123.59,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","DPM1","ENSG00000000419","N-Glycan biosynthesis; Metabolic pathways","Synthesis of dolichyl-phosphate mannose; Defective DPM1 causes DPM1-CDG (CDG-1e); Defective DPM3 causes DPM3-CDG (CDG-1o); Defective DPM2 causes DPM2-CDG (CDG-1u)","VEGFA-VEGFR2 signaling pathway",7159.7,7112.1,7533.5,7693.1,6668,5618.6,1.0913727433344844,0.126143918451921,0.3774005357878209,0.4231974876116574,0.5660620800478521,0.24713593710897896,4873]
["O60763-1","General vesicular transport factor p115 [OS=Homo sapiens]",48,41,195,41,962,107.8,4.91,605.23,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","","USO1","ENSG00000138768","","COPI-mediated anterograde transport; COPII-mediated vesicle transport; Golgi Cisternae Pericentriolar Stack Reorganization","",20901.9,20868,20914.9,21250.5,21834.1,16130,1.058603790281451,0.08216272459691608,0.5579484658194396,0.25340591225204734,0.6906088631116485,0.16076785231760793,5905]
["O60783","28S ribosomal protein S14, mitochondrial [OS=Homo sapiens]",12,1,3,1,128,15.1,11.41,11.73,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus","other molecular function","MRPS14","ENSG00000120333","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",37.6,34.3,33.9,31.4,43.4,77.3,0.6955950032873112,-0.5236805256104706,0.32584541080130325,0.4869883912180378,0.5442422549238404,0.2642077426594392,4376]
["O60784","Target of Myb protein 1 [OS=Homo sapiens]",57,19,81,19,492,53.8,4.7,205.96,"transport;signal transduction","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","TOM1","ENSG00000100284","","Neutrophil degranulation","",4246.4,4183.6,4188.5,4893,4972.1,6049.1,0.7929082203315279,-0.3347742122311751,0.042311407786524285,1.3735425245683053,0.2146107422010451,0.6683485434983217,1441]
["O60825-1","6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 [OS=Homo sapiens]",46,19,72,1,505,58.4,8.38,198.67,"other metabolic processes;other biological processes","cytosol;nucleus","kinase activity;other molecular function","PFKFB2","ENSG00000123836; ENSGGOG00000012227; ENSPPAG00000041619; ENSPTRG00000001925","Fructose and mannose metabolism; Metabolic pathways; AMPK signaling pathway; Thyroid hormone signaling pathway","Regulation of glycolysis by fructose 2,6-bisphosphate metabolism","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Thyroid hormones production and peripheral downstream signaling effects",5085.7,4976,5358.8,5229.1,4670.4,5312.8,1.0136862933284252,0.019611248906486623,0.7793101653756238,0.10828965875665138,0.8506538229884162,0.07024714185788196,6696]
["O60825-2","Isoform 2 of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 [OS=Homo sapiens]",50,19,71,1,471,54.4,7.56,198.67,"","","","PFKFB2","","","","",133.1,132,123.1,125.4,114.2,134.1,1.0388011774150387,0.054919554332919125,0.5028942410039013,0.2985233377625444,0.6515961722207969,0.18602147560396506,5641]
["O60826","Coiled-coil domain-containing protein 22 [OS=Homo sapiens]",26,14,30,14,627,70.7,6.74,85.37,"transport;other biological processes","cytosol;nucleus;other cytoplasmic organelle","other molecular function","CCDC22","ENSG00000101997","","Neddylation","",2425.3,2319.9,2366.6,2573.7,2576.3,2127.6,0.9772177640980544,-0.033248005388588915,0.7349257827113156,0.13375651640748223,0.8163484112214293,0.08812444813746481,6580]
["O60828","Polyglutamine-binding protein 1 [OS=Homo sapiens]",19,4,9,4,265,30.5,6.33,27.86,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","PQBP1","ENSG00000102103","Spliceosome","mRNA Splicing - Major Pathway","",697.9,594.6,606.2,937,943.8,1001.3,0.6587904652857292,-0.6021084198846274,1.0454101166323102E-3,2.980713301467722,0.0400047253532228,1.3978887068314767,191]
["O60830-1","Mitochondrial import inner membrane translocase subunit Tim17-B [OS=Homo sapiens]",30,5,15,5,172,18.3,9.03,43.72,"cell organization and biogenesis;transport","other membranes;mitochondrion","transporter activity","TIMM17B","ENSG00000126768; ENSGGOG00000011427; ENSNLEG00000007902; ENSPPAG00000036547; ENSPPYG00000020323; ENSPTRG00000021872","","Mitochondrial protein import","",1826.6,1860.1,1921,1912.9,2016.6,1980.8,0.9488012452836573,-0.07582219149229705,0.07007563368563692,1.1544329662764734,0.27042386832540666,0.567954979059755,1894]
["O60831","PRA1 family protein 2 [OS=Homo sapiens]",22,3,7,3,178,19.2,9.19,15.69,"transport","other membranes;other cytoplasmic organelle","","PRAF2","ENSG00000243279","","","",360.2,351,400.4,325.1,345,536.4,0.92134272689598,-0.11819017590255206,0.6706417922205428,0.17350938624088824,0.767092466250383,0.11515228251531544,6390]
["O60832-1","H/ACA ribonucleoprotein complex subunit 4 [OS=Homo sapiens]",53,27,113,27,514,57.6,9.42,378.31,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DKC1","ENSG00000130826; ENSGGOG00000001045; ENSPTRG00000022449","Ribosome biogenesis in eukaryotes","rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase","",17237.5,17465.5,17260.6,17538.2,16910.5,17734.1,0.9957993821719034,-0.006072974580615981,0.7916650229298704,0.1014585424849599,0.8597740939961995,0.06561564482496379,6730]
["O60841","Eukaryotic translation initiation factor 5B [OS=Homo sapiens]",41,55,214,54,1220,138.7,5.49,606.45,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","EIF5B","ENSG00000158417","","GTP hydrolysis and joining of the 60S ribosomal subunit","Translation factors; Ciliary landscape",28287.8,27368.5,27260.9,28722.6,29131.3,18313.4,{"$f":"AVERAGE(S514:U514)/AVERAGE(V514:X514)","v":1.0886193944120381},{"$f":"LOG(Y514,2)","v":0.12249964388814188},{"$f":"TTEST(V514:X514,S514:U514,2,2)","v":0.5611513738702105},0.2509199694590766,{"$f":"AA514*7309/AE514","v":0.6932818444248426},0.15909017289995844,5916]
["O60861-1","Isoform 1 of Growth arrest-specific protein 7 [OS=Homo sapiens]",7,2,3,2,412,47.2,7.58,8.59,"","","","GAS7","","","","",327.8,341.5,327.6,580.2,576.6,168,0.7524909420289854,-0.41025387908613786,0.4693027538986882,{"$f":"-LOG10(AA515)","v":0.32854689731212733},0.6276548633569098,{"$f":"-LOG10(AC515)","v":0.20227910171387598},5465]
["O60869-1","Endothelial differentiation-related factor 1 [OS=Homo sapiens]",10,1,1,1,148,16.4,9.95,2.52,"developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","EDF1; LOC101354658; LOC113248658","ENSBIXG00000009641; ENSBIXG00005005090; ENSBTAG00000030302; ENSCATG00000040060; ENSCCAG00000020655; ENSCJAG00000011166; ENSCSAG00000016077; ENSECAG00000012630; ENSFCAG00000000388; ENSG00000107223; ENSLCNG00005013346; ENSPANG00000026162; ENSPCOG00000009350; ENSRFEG00010005371","","","",242.9,251.6,251.4,225.5,236.7,207.8,1.1132835820895521,0.15482113119094615,0.04655784132430451,1.3320071641544795,0.2228495496000928,0.6519882393269276,1527]
["O60870","DNA/RNA-binding protein KIN17 [OS=Homo sapiens]",13,5,13,5,393,45.3,8.95,36.4,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response","nucleus;other cell component","nucleic acid binding activity;other molecular function","KIN","ENSG00000151657","","Protein methylation","",677,748.5,690.6,1031.1,998.5,1108,0.6744326874043856,-0.5682536345068376,9.6403506667635727E-4,3.0159071683927543,0.03892890774772097,1.409727781377966,181]
["O60879-2","Isoform 2 of Protein diaphanous homolog 2 [OS=Homo sapiens]",18,20,36,18,1096,124.7,6.43,109.53,"","","","DIAPH2","","","","",3764,3656.8,3841.9,3666.3,3801.7,2043.3,1.184138866401018,0.2438382787036735,0.3617180512678771,0.44162981755739245,0.5589423333439564,0.25263299641123105,4730]
["O60884","DnaJ homolog subfamily A member 2 [OS=Homo sapiens]",37,14,52,14,412,45.7,6.48,156.08,"stress response;other biological processes","other membranes;cytosol","other molecular function","DNAJA2","ENSG00000069345","Protein processing in endoplasmic reticulum","HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand","",6401.5,6027.1,6313.8,6382.7,6463.7,6425.5,0.9725247640346826,-0.04019310803258856,0.20104237300569183,0.6967123981858981,0.44690349887427055,0.349786245169938,3288]
["O60885-1","Bromodomain-containing protein 4 [OS=Homo sapiens]",4,5,6,5,1362,152.1,9.19,12.26,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","kinase activity;other molecular function","BRD4","ENSG00000141867; ENSPTRG00000010619","","Potential therapeutics for SARS","VEGFA-VEGFR2 signaling pathway; 7q11.23 copy number variation syndrome",295.8,299.1,273.2,2149.6,2182.1,1282.2,0.15463403338142828,-2.6930702181405657,5.823231481456418E-3,2.234835945746168,0.0829668594502241,1.0810953489740112,513]
["O60888-1","Protein CutA [OS=Homo sapiens]",47,5,48,5,179,19.1,5.5,156.55,"other biological processes","other membranes","other molecular function","CUTA","ENSG00000112514; ENSG00000226492","","","",2704,3217.2,2558.8,2634.6,3118.3,2518.3,1.025244220911113,0.035967611515530164,0.8102263438042467,0.09139364021584935,0.8715149885011391,0.05972513940038946,6795]
["O60906","Sphingomyelin phosphodiesterase 2 [OS=Homo sapiens]",6,2,3,2,423,47.6,6.98,6.62,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","SMPD2","ENSG00000135587","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway","Glycosphingolipid metabolism; Ceramide signalling; TNFR1-mediated ceramide production","TNF-alpha signaling pathway; S1P receptor signal transduction",68.8,73.2,62.1,55.9,68.3,219.4,0.5940046565774155,-0.7514538541057445,0.42705376305916615,0.36951744691847227,0.598415635390998,0.22299706775836312,5216]
["O60907","F-box-like/WD repeat-containing protein TBL1X [OS=Homo sapiens]",14,7,25,2,577,62.5,6.55,91.11,"protein metabolism;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","TBL1X","ENSG00000101849","Wnt signaling pathway","Heme signaling; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; RORA activates gene expression","Ectoderm differentiation; Ectoderm differentiation; Rett syndrome causing genes",49.7,47.7,64.1,63.8,61,102.8,0.7095782073813709,-0.4949663927252946,0.20189655722994687,0.6948710866471702,0.4473058310984182,0.3493954403085412,3299]
["O60921","checkpoint protein HUS1 [OS=Homo sapiens]",20,4,9,4,280,31.7,6.84,31.78,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","","HUS1","ENSG00000136273","Cellular senescence","Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA)","ATR signaling",386.7,362.7,394.5,358.7,362,307.9,1.1120941084969864,0.15327887809481436,0.12637186450320656,0.898349606837925,0.3610836425543146,0.4423921850965872,2558]
["O60925","prefoldin subunit 1 [OS=Homo sapiens]",8,1,1,1,122,14.2,6.81,3.51,"other biological processes","other cell component","other molecular function","PFDN1","ENSG00000113068","","Prefoldin mediated transfer of substrate  to CCT/TriC","Cellular proteostasis",110.6,156.5,105.8,134.5,170.2,154.9,0.8113577023498695,-0.30159000087247206,0.20643466438113628,0.6852173744605239,0.45201646553676605,0.3448457449197788,3338]
["O60927","Protein phosphatase 1 regulatory subunit 11 [OS=Homo sapiens]",12,1,2,1,126,13.9,7.01,8.98,"protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","enzyme regulator activity;other molecular function","PPP1R11","ENSG00000204619; ENSG00000206501; ENSG00000227720; ENSG00000233314; ENSG00000234058; ENSG00000236560; ENSG00000237403; ENSG00000237829","","","",93.6,89,108,154.3,154.1,211.2,0.55927636643572,-0.8383667278150393,0.01835238369567067,1.7363075194967232,0.14119744466490203,0.850173162901598,950]
["O60930","Ribonuclease H1 [OS=Homo sapiens]",7,2,3,2,286,32,9.16,10.07,"RNA metabolism OR transcription;other metabolic processes","other cell component","nucleic acid binding activity;other molecular function","RNASEH1","ENSG00000171865","DNA replication","","",377.8,371.7,373.4,415.2,389.8,467.9,0.8821588498703747,-0.1808896303907744,0.09611621802863642,1.0172033261079185,0.31888944056799984,0.4963598613747131,2203]
["O60934","Nibrin [OS=Homo sapiens]",12,7,14,7,754,84.9,6.9,28.06,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NBN","ENSG00000104320","Homologous recombination; Cellular senescence","Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks","miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM signaling in development and disease ; Breast cancer pathway; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; DNA damage response",1184.8,1206.2,1162.8,1486.5,1639.8,1418.9,0.781879785267975,-0.3549812859862021,7.670337481459232E-3,2.1151855274315783,0.09220805370392356,1.0352311448203404,608]
["O60942-1","mRNA-capping enzyme [OS=Homo sapiens]",19,10,25,10,597,68.5,8.13,62.35,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","RNGTT","ENSG00000111880; ENSGGOG00000007863; ENSNLEG00000013064; ENSPPAG00000024828; ENSPTRG00000018413","mRNA surveillance pathway","RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE","mRNA processing; Ciliary landscape; mRNA Processing",1780.2,1762.1,1836.2,1834.7,1902.7,2316.3,0.8884649057601135,-0.17061330376090406,0.21311571449202119,0.671384525576517,0.45867572356365804,0.33849424526445915,3396]
["O75027-1","ATP-binding cassette sub-family B member 7, mitochondrial [OS=Homo sapiens]",26,17,33,16,752,82.6,9.33,94.31,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","ABCB7","ENSG00000131269","ABC transporters","Mitochondrial ABC transporters; Cytosolic iron-sulfur cluster assembly","",3625.4,3560.8,3288.6,2939,3176.3,3174.4,1.1275713962775977,0.17321878584833084,0.038305343075732884,1.4167406436172068,0.2036172745749321,0.6911853798995152,1375]
["O75037","Kinesin-like protein KIF21B [OS=Homo sapiens]",8,10,15,9,1637,182.5,7.08,40.29,"other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF21B","ENSG00000116852","","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",809.7,809.6,818.8,1111.7,1013.6,2361,0.5434545170853489,-0.8797687969322807,0.1905707461390545,0.7199437656361367,0.43622974742572795,0.3602847222916086,3193]
["O75044","SLIT-ROBO Rho GTPase-activating protein 2 [OS=Homo sapiens]",31,28,60,28,1071,120.8,6.7,171.11,"","","","","","","","",7296.7,7284.9,7263,6965.9,6721.1,6491.6,1.0825627149554478,0.11445060549182881,0.015543091680800404,1.8084625913031769,0.13013110778347098,0.8856188731247736,873]
["O75052","Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein [OS=Homo sapiens]",12,5,15,4,506,56.1,6.3,29.74,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","NOS1AP","ENSG00000198929","Circadian entrainment","","Sudden infant death syndrome (SIDS) susceptibility pathways",377.5,388.1,406.1,401.4,400,780.2,0.7408320687910978,-0.43278154423128884,0.34180178403083145,0.46622567481386706,0.5499073826725396,0.2597104497445201,4543]
["O75063","Glycosaminoglycan xylosylkinase [OS=Homo sapiens]",15,5,12,5,409,46.4,6.87,36.6,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;nucleus","kinase activity;other molecular function","FAM20B","ENSG00000116199","","","",836.8,802.2,841.5,863.6,888.8,1116.4,0.8646472392638036,-0.2098164360883344,0.186786550393421,0.7286543984496645,0.43121380190319464,0.36530734709202867,3166]
["O75064","DENN domain-containing protein 4B [OS=Homo sapiens]",4,5,8,5,1496,163.7,7.21,29.61,"other biological processes","cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity","DENND4B","ENSG00000198837","","RAB GEFs exchange GTP for GDP on RABs","",508.9,504.2,543.3,523.3,483.8,1231.7,0.6951938538502768,-0.5245127674227973,0.4027510354918603,0.3949633343157639,0.5823357702096947,0.23482653235881082,5055]
["O75071","EF-hand calcium-binding domain-containing protein 14 [OS=Homo sapiens]",3,2,2,2,495,55,6.32,2.24,"","","other molecular function","EFCAB14","ENSG00000159658","","","",187.8,178.5,216.7,210.3,222.6,379.4,0.7177151298781239,-0.4785167609546828,0.24144947586130874,0.617173733029377,0.4844233376531171,0.31477494238731984,3643]
["O75083","WD repeat-containing protein 1 [OS=Homo sapiens]",66,28,263,28,606,66.2,6.65,1018.95,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity","WDR1","ENSG00000071127","","Platelet degranulation","Hypertrophy model",29698.4,29885.1,30191.1,28306.9,25728,25594,1.1274122837311582,0.17301519157480458,0.01941716712653854,1.7118141313309732,0.14422771801612824,0.8409512678783417,984]
["O75093-1","Slit homolog 1 protein [OS=Homo sapiens]",1,1,1,1,1534,167.8,6.57,1.87,"cell organization and biogenesis;transport;developmental processes;other biological processes","non-structural extracellular","signal transduction activity or receptor binding;other molecular function","SLIT1","ENSG00000187122","Axon guidance","Regulation of expression of SLITs and ROBOs; Netrin-1 signaling; Regulation of cortical dendrite branching; Regulation of commissural axon pathfinding by SLIT and ROBO","Spinal cord injury",244.5,240.6,243.4,273.9,262.7,391.5,0.7849369679991381,-0.3493512875151131,0.1817215120259566,0.7405936582661858,0.4251608615229567,0.37144672158747566,3124]
["O75113","NEDD4-binding protein 1 [OS=Homo sapiens]",19,12,17,12,896,100.3,5.36,60.04,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","N4BP1","ENSG00000102921","","","",812.8,807.7,827.1,937.6,904.2,834.9,0.9144095341278439,-0.12908764893858926,0.06823465048044668,1.1659950287029486,0.2671275095669977,0.5732813847680539,1867]
["O75116","Rho-associated protein kinase 2 [OS=Homo sapiens]",29,34,65,28,1388,160.8,6.02,166.7,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;kinase activity;other molecular function","ROCK2","ENSG00000134318","cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Vascular smooth muscle contraction; Wnt signaling pathway; Axon guidance; Focal adhesion; Tight junction; Platelet activation; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Human cytomegalovirus infection; Pathways in cancer; Proteoglycans in cancer; Lipid and atherosclerosis","RHOA GTPase cycle; RHOB GTPase cycle; RHOC GTPase cycle; G alpha (12/13) signalling events; Potential therapeutics for SARS; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHOBTB1 GTPase cycle; RHOH GTPase cycle","Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Pathogenic Escherichia coli infection; Spinal cord injury; Focal adhesion; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; Wnt signaling; Airway smooth muscle cell contraction; Regulation of actin cytoskeleton; G13 signaling pathway",5285.7,5173,5048.6,5494.7,5485.7,4088.7,1.0290793743488331,0.04135426363426016,0.7724962800275617,0.1121036032525034,0.8458689604077075,0.0726969114051433,6675]
["O75122","CLIP-associating protein 2 [OS=Homo sapiens]",29,29,71,1,1294,141,8.47,187.27,"","","","","","","","",16.8,11.9,20.9,16,21.4,30.2,0.7337278106508877,-0.4466831258953089,0.2869320901116142,0.5422208781079738,0.5185921480281375,0.28517406314296434,4044]
["O75122-3","Isoform 3 of CLIP-associating protein 2 [OS=Homo sapiens]",24,29,71,1,1515,165.8,8.37,188.79,"","","","","","","","",5261,5305,5278.2,5824.7,5843.1,7082.7,0.8450014666275566,-0.24297424947542026,0.08060592787145665,1.0936330184033867,0.2900781520494715,0.5374849799242205,2031]
["O75127","pentatricopeptide repeat-containing protein 1, mitochondrial [OS=Homo sapiens]",15,8,17,8,700,78.8,8.59,43.17,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","nucleic acid binding activity","PTCD1","ENSG00000106246","","","",1384.7,1380.7,1439.1,1658.4,1671.1,1816.2,0.8170899974736188,-0.2914331037157447,0.004369625666643183,2.359555766204533,0.07242084806688213,1.1401363937883984,441]
["O75131","Copine-3 [OS=Homo sapiens]",46,20,84,19,537,60.1,5.85,274.59,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","CPNE3","ENSG00000085719","","Neutrophil degranulation; Glycerophospholipid biosynthesis","",10664,10522,10365.2,9807.3,9514,11112.7,1.036708943944273,0.05201091433735938,0.4968711571730586,0.3037562128422003,0.6468883661877245,0.1891706592566476,5614]
["O75132","Zinc finger BED domain-containing protein 4 [OS=Homo sapiens]",2,2,2,2,1171,130.2,6.83,7.41,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBED4","ENSG00000100426","","","",116.3,133.4,131.6,140.7,137,218.8,0.7679758308157099,-0.3808671866896214,0.23111526165848661,0.6361713750089072,0.4771811998479883,0.3213166751507221,3540]
["O75140-1","Isoform 1 of GATOR complex protein DEPDC5 [OS=Homo sapiens]",8,9,10,9,1572,177.8,6.73,33.77,"","","","DEPDC5","","","","",678.6,657.7,667.9,700.4,665.7,851.7,0.9036883397961943,-0.14610278702003449,0.28275195546205667,0.5485943828889999,0.5162713071376898,0.2871220111101321,4003]
["O75143-1","Autophagy-related protein 13 [OS=Homo sapiens]",17,5,9,5,517,56.5,5.12,27.52,"cell organization and biogenesis;other metabolic processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cell component","other molecular function","ATG13","ENSG00000175224","Autophagy; Autophagy; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration","Macroautophagy","Alzheimer's disease and miRNA effects; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Host-pathogen interaction of human coronaviruses - autophagy; Autophagy; Malignant pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; Senescence and autophagy in cancer",678.7,672.6,696.7,939.2,911.7,1145.8,0.6834184269362966,-0.5491589473671613,0.01305237133997125,1.8843105790301693,0.11954859915269406,0.9224555084969257,798]
["O75144-1","ICOS ligand [OS=Homo sapiens]",4,1,1,1,302,33.3,5.31,2.94,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","ICOSLG","ENSG00000160223","Cell adhesion molecules; Intestinal immune network for IgA production","Costimulation by the CD28 family","",79.6,80.3,88,88.8,92.6,147,0.7548721071863581,-0.4056958556910826,0.23052999003114302,0.637272568505088,0.47651122656607026,0.3219268629621505,3536]
["O75145-1","Liprin-alpha-3 [OS=Homo sapiens]",1,2,2,1,1194,133.4,5.68,4.59,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","non-structural extracellular;cytosol;other cell component","","PPFIA3","ENSG00000177380","","Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Receptor-type tyrosine-protein phosphatases","",271.3,298.7,297.6,330,301.1,639.1,0.6830420406235238,-0.5499537170564717,0.2839518467130676,0.5467553024878757,0.5170413671215274,0.28647470875536957,4014]
["O75146","Huntingtin-interacting protein 1-related protein [OS=Homo sapiens]",25,25,37,25,1068,119.3,6.67,110.28,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component","cytoskeletal activity;other molecular function","HIP1R","ENSG00000130787","","Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis","",3410.8,3409.9,3379.7,3500.6,3424.6,5411.7,0.8268203519522733,-0.27435419415103424,0.33487484869217277,0.4751174696126837,0.547316697023947,0.26176130260707753,4472]
["O75150","E3 ubiquitin-protein ligase BRE1B [OS=Homo sapiens]",39,36,87,33,1001,113.6,6.23,274.24,"protein metabolism;other metabolic processes","nucleus","other molecular function","RNF40","","","","",7238.5,7280.4,7213.1,7649.3,7730.5,8338.4,0.9162584007218086,-0.12617357422030345,0.03868223116044709,1.4124884841049394,0.20457918057287106,0.689138565259146,1382]
["O75151","lysine-specific demethylase phf2 [OS=Homo sapiens]",7,6,6,6,1096,120.7,9.17,14.18,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","other molecular function","PHF2","ENSG00000197724","","HDMs demethylate histones","",286.9,277.9,290.6,321.9,347,450.6,0.7640911121036176,-0.3881834158636264,0.09012924196422324,1.0451342815701505,0.30811722615365184,0.5112840205589367,2138]
["O75152","Zinc finger CCCH domain-containing protein 11A [OS=Homo sapiens]",35,26,48,26,810,89.1,8.37,125.72,"other metabolic processes;transport","nucleus","nucleic acid binding activity;other molecular function","ZC3H11A","ENSG00000058673","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","",6023.3,5720.4,5950.6,6431.8,6612.9,5477.3,0.9553126012309688,-0.06595520001065008,0.4905498191132462,0.3093168800938609,0.6414004701071049,0.19287072609631123,5590]
["O75153","Clustered mitochondria protein homolog [OS=Homo sapiens]",24,22,46,22,1309,146.6,6.13,135.35,"cell organization and biogenesis","other cell component","nucleic acid binding activity","CLUH","ENSG00000132361","","","Translation factors",4754.6,4640.1,4763.6,6413.4,6103.6,4640.8,0.8251815500821784,-0.27721652996750934,0.14215351302664048,0.847242403161492,0.38058609037059166,0.4195470883182751,2730]
["O75157","TSC22 domain family protein 2 [OS=Homo sapiens]",6,5,11,3,780,79.2,5.02,19.03,"stress response;other biological processes","","","TSC22D2","ENSG00000196428","","","",555.8,572.6,569.1,571.1,605.2,538.3,0.9900268284147905,-0.014460474042046041,0.7895885698290239,0.10259914718759912,0.8587950679881452,0.06611045835745141,6720]
["O75164-1","Lysine-specific demethylase 4A [OS=Homo sapiens]",12,9,18,9,1064,120.6,5.85,58.62,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","KDM4A","ENSG00000066135","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux","",844.9,842.1,881.5,1137.1,1113.6,1404.9,0.7026206368311632,-0.5091821439793058,0.018409393061710997,1.7349605294913608,0.14133850198324127,0.8497395159918621,952]
["O75165","DnaJ homolog subfamily C member 13 [OS=Homo sapiens]",30,57,155,57,2243,254.3,6.74,473.49,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","","DNAJC13","ENSG00000138246","","Neutrophil degranulation","",14709.1,14795.4,14746.6,14905.2,14569.8,18052.4,0.9310650277524123,-0.10304616239898358,0.3806798379741929,0.4194401242059313,0.5677186157423741,0.245866864834588,4901]
["O75167","Phosphatase and actin regulator 2 [OS=Homo sapiens]",2,2,2,1,634,69.7,8.16,3.9,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes","enzyme regulator activity;cytoskeletal activity","PHACTR2","ENSG00000112419","","Platelet degranulation","",35.5,54.3,47.2,52.1,47.1,204.9,0.4505097007563301,-1.1503699231829088,0.34505343101443703,0.4621136498599849,0.5523424282270084,0.25779159513022837,4566]
["O75170","Serine/threonine-protein phosphatase 6 regulatory subunit 2 [OS=Homo sapiens]",25,14,27,14,966,104.9,4.87,59.4,"other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP6R2","ENSG00000100239","","","",978.6,996.3,1013.1,1037.9,1065.8,952.8,0.9775887452969082,-0.03270041897560883,0.5542056995355107,0.2563290121804677,0.6876064263970544,0.16266007303248806,5891]
["O75175","CCR4-NOT transcription complex subunit 3 [OS=Homo sapiens]",7,5,14,5,753,81.8,6.2,35.81,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","","CNOT3","ENSG00000088038; ENSG00000273943; ENSG00000274176; ENSG00000274616; ENSG00000274941; ENSG00000275979; ENSG00000276082; ENSG00000277114; ENSG00000277600; ENSG00000277615","RNA degradation","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","",868.5,838.9,792.6,1192.6,1226.6,1051.6,0.7202950328454536,-0.47334013938857517,0.005042960829112128,2.297314405183425,0.07859061982938281,1.1046292860145355,469]
["O75177","Calcium-responsive transactivator [OS=Homo sapiens]",6,2,2,2,396,43,6.44,5.82,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","SS18L1","ENSG00000184402","","","",172.5,174.8,172.2,218.1,211.6,225.2,0.7932508779966407,-0.33415088192037307,3.5575630002370736E-4,3.448847400333473,0.02241571376614894,1.6494474276764182,116]
["O75179-1","Ankyrin repeat domain-containing protein 17 [OS=Homo sapiens]",14,29,48,17,2603,274.1,6.52,133.09,"stress response;developmental processes;other biological processes","other membranes;nucleus;other cell component","other molecular function","ANKRD17","ENSG00000132466","","","",3729.4,3967.4,3811.2,4840.6,4741.1,4272.8,0.830632646432567,-0.2677175196322516,0.014257742486000353,1.8459492334944707,0.12405933313116259,0.9063705576723795,840]
["O75182-2","Isoform 2 of Paired amphipathic helix protein Sin3b [OS=Homo sapiens]",8,6,10,5,1130,129.3,6.98,26.85,"","","","SIN3B","","","","",177.9,158,181,191.9,203.3,184.1,0.8922837907819781,-0.16442546272570244,0.08450178034985295,1.0731341408967954,0.2982247767151498,0.525456277906275,2071]
["O75190","DnaJ homolog subfamily B member 6 [OS=Homo sapiens]",30,8,18,7,326,36.1,9.16,53.64,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","DNAJB6","ENSG00000105993","","Regulation of HSF1-mediated heat shock response","",1480.6,1510.9,1509.5,1596.8,1618.9,1495.7,0.9553423610816318,-0.06591025794646849,0.14801158308007223,0.829704296288038,0.3858119332140685,0.41362434369868606,2804]
["O75191","xylulose kinase [OS=Homo sapiens]",4,2,2,2,536,58.3,5.86,6.13,"other metabolic processes","cytosol","kinase activity;other molecular function","XYLB","ENSG00000093217","Pentose and glucuronate interconversions; Metabolic pathways","Formation of xylulose-5-phosphate","",149.3,188.6,171.8,161.6,138.9,299.8,0.8490754622688657,-0.23603531472152048,0.5894565026206814,0.22954823699601962,0.7115338691419587,0.14780442259111773,6055]
["O75208-1","Ubiquinone biosynthesis protein COQ9, mitochondrial [OS=Homo sapiens]",18,4,13,4,318,35.5,5.94,59.67,"other metabolic processes","other membranes;mitochondrion","other molecular function","COQ9","ENSG00000088682","","Ubiquinol biosynthesis","",809.8,822.5,819.7,644.7,741.2,613.2,1.2265519483767695,0.29460833791380403,0.017524434857876824,1.7563559786145468,0.13743143173414346,0.8619139290845553,932]
["O75223-1","gamma-glutamylcyclotransferase [OS=Homo sapiens]",54,9,45,9,188,21,5.14,115.66,"cell organization and biogenesis;signal transduction","cytosol","other molecular function","C7orf24; GGCT","ENSG00000006625; ENSGGOG00000024930; ENSPPAG00000031715; ENSPTRG00000019041","Glutathione metabolism; Metabolic pathways","Glutathione synthesis and recycling","Gamma-glutamyl cycle for the biosynthesis and degradation of glutathione, including diseases",5437.8,5496.9,5420.7,5184.2,4634.5,3910,1.1913291134630373,0.25257202342036406,0.0769636416308777,1.1137143912979663,0.2848239274329545,0.5454235293764724,1975]
["O75251","NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [OS=Homo sapiens]",14,3,27,3,213,23.5,9.99,53.49,"cell organization and biogenesis;other metabolic processes;transport","plasma membrane;other membranes;mitochondrion;other cell component","transporter activity;other molecular function","NDUFS7","ENSG00000115286","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",2717.5,2680.2,2811.5,2800.9,2771.1,5203.5,0.7618393578024222,-0.39244127319818034,0.3488084065306265,0.4574130568075096,0.5533841205409918,0.25697330717621625,4607]
["O75306-1","NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [OS=Homo sapiens]",47,17,73,17,463,52.5,7.55,235.08,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion;nucleus","transporter activity;other molecular function","NDUFS2","ENSG00000158864","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",7519.8,7544,7801.6,7397.9,6906.8,7210.3,1.062765512433186,0.08782331712538077,0.05629690699463071,1.2495154650432205,0.24463382474658493,0.6114834946211409,1682]
["O75312","Zinc finger protein ZPR1 [OS=Homo sapiens]",45,15,37,15,459,50.9,4.73,120.57,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ZPR1","ENSG00000109917","","","",3572.8,3494.1,3425.3,3652.9,4076.2,4109.1,0.886300282137487,-0.17413252234325827,0.04266510106335928,1.3699272212909868,0.21535857988404214,0.6668378212681418,1448]
["O75323-1","Protein NipSnap homolog 2 [OS=Homo sapiens]",24,6,16,5,286,33.7,9.36,44.31,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;mitochondrion","","NIPSNAP2","ENSG00000146729","","RHOJ GTPase cycle; RHOH GTPase cycle","",1469.5,1513.1,1477.5,1410.5,1400.6,1710.6,0.986376805183891,-0.019789219963739495,0.8511452899234442,0.06999629981402979,0.9014665880380313,0.04505036533605545,6901]
["O75330-1","Hyaluronan mediated motility receptor [OS=Homo sapiens]",36,25,38,24,724,84,5.83,108.57,"","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","HMMR","ENSG00000072571","ECM-receptor interaction","AURKA Activation by TPX2; Hyaluronan uptake and degradation","",3735.8,3761.3,3664.3,3954.1,4134.7,4218.1,0.9069221331123192,-0.14094940631124567,0.010089230398391654,1.9961419602724093,0.10549668809992074,0.9767611741341179,699]
["O75335-1","Isoform 1 of Liprin-alpha-4 [OS=Homo sapiens]",1,1,1,1,701,78,7.28,2.27,"","","","PPFIA4","","","","",200,201.1,202.2,176.2,171,354.6,0.859646622969507,-0.21818436537565852,0.6153437479486805,0.21088220758821904,0.7291743602070211,0.13716861074714662,6168]
["O75340","programmed cell death protein 6 [OS=Homo sapiens]",40,6,30,6,191,21.9,5.4,63.06,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PDCD6","ENSG00000249915","","","Epithelial to mesenchymal transition in colorectal cancer",4576.3,5045.1,4692.7,4434.6,4718.8,5267,0.9926284985159914,-0.010674219662480586,0.9060795287287366,0.04283368160329831,0.9403003372821719,0.02673340811165659,7043]
["O75347","Tubulin-specific chaperone A [OS=Homo sapiens]",34,5,6,5,108,12.8,5.29,13.87,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","TBCA","ENSG00000171530","","Post-chaperonin tubulin folding pathway","VEGFA-VEGFR2 signaling pathway",635.1,612,804.6,662.4,642.2,1172.1,0.8284006944724835,-0.27159933187506496,0.4836014724715797,0.315512385467783,0.6361848744231059,0.19641666064938793,5556]
["O75348","V-type proton ATPase subunit G 1 [OS=Homo sapiens]",7,1,1,1,118,13.7,8.79,1.8,"transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle","transporter activity;other molecular function","ATP6V1G1","ENSG00000136888","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis","Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Osteoclast signaling; Proximal tubule transport",139,163.4,174.3,155.7,174,213.7,0.8772543246227458,-0.18893294015229947,0.3296307630175098,0.4819722642525114,0.5448374597229714,0.2637330406112335,4422]
["O75351","Vacuolar protein sorting-associated protein 4B [OS=Homo sapiens]",58,20,82,16,444,49.3,7.23,209.91,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","VPS4B","ENSG00000119541","Endocytosis; Necroptosis","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)","",8639,8827.5,8711.1,9435,9482.8,7210.3,1.0018945120387628,2.7306173454598346E-3,0.9835382870611755,0.00720872925176297,0.9894950227295433,0.004586386001830346,7265]
["O75352","Mannose-P-dolichol utilization defect 1 protein [OS=Homo sapiens]",10,2,24,2,247,26.6,8.94,56.6,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","","MPDU1","ENSG00000129255","","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective MPDU1 causes CDG-1f","",1650.7,1605,1716.3,1346.7,1400.8,1769.4,{"$f":"AVERAGE(S578:U578)/AVERAGE(V578:X578)","v":1.1007549425490935},{"$f":"LOG(Y578,2)","v":0.13849332219900135},{"$f":"TTEST(V578:X578,S578:U578,2,2)","v":0.3292605533282207},0.4824602963091979,{"$f":"AA578*7309/AE578","v":0.5444718063972771},0.26402460377431686,4420]
["O75354-1","Ectonucleoside triphosphate diphosphohydrolase 6 [OS=Homo sapiens]",2,1,2,1,484,53.2,9.26,6.59,"other metabolic processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","ENTPD6","ENSG00000197586","Purine metabolism; Pyrimidine metabolism; Metabolic pathways","Phosphate bond hydrolysis by NTPDase proteins","",80.5,87.9,100.6,107.4,101.6,173.9,0.7025332985113607,-0.5093614874061742,0.18772269843115608,{"$f":"-LOG10(AA579)","v":0.726483211622669},0.43214652057742353,{"$f":"-LOG10(AC579)","v":0.36436897936669055},3175]
["O75362","zinc finger protein 217 [OS=Homo sapiens]",5,5,5,4,1048,115.2,8.48,14.96,"other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","ZNF217","ENSG00000171940","","Estrogen-dependent gene expression","",201.1,205.9,202.8,679.9,793.7,323,0.33941890237114547,-1.5588611835196025,0.04931826215187943,1.3069922352220176,0.2287228287234053,0.6406904864915812,1576]
["O75367-1","Core histone macro-H2A.1 [OS=Homo sapiens]",48,16,177,16,372,39.6,9.79,596.35,"cell organization and biogenesis;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","H2afy; H2AFY; LOC100466888; LOC101338325; LOC101381952; LOC101564704; LOC102987354; LOC103079324; LOC103663804; LOC106989149; LOC109250833; LOC110591142; LOC111141291; LOC111182462; LOC112404331; LOC112815157; LOC112861289; LOC112917035; LOC113261754; LOC113928700; LOC115516119; LOC116529369; MACROH2A1","ENSAMEG00000017887; ENSCAFG00000001076; ENSCANG00000022762; ENSCJAG00000005818; ENSFCAG00000013924; ENSG00000113648; ENSGGOG00000001707; ENSLCNG00005003680; ENSMLEG00000037795; ENSMNEG00000031666; ENSMPUG00000010011; ENSPCOG00000013464; ENSPCTG00005011747; ENSPPAG00000029258; ENSPTRG00000017256; ENSRBIG00000034425; ENSRROG00000045755; ENSSBOG00000034640; ENSSSUG00005001976; ENSVVUG00000017487","Necroptosis; Neutrophil extracellular trap formation; Alcoholism; Systemic lupus erythematosus","","H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma",28861.5,28672.3,28163.5,24213.7,25486.6,17375.4,1.2776206584500793,0.3534595456658881,0.06997582308693051,1.1550519844658054,0.27032414954670986,0.5681151546476064,1892]
["O75368","SH3 domain-binding glutamic acid-rich-like protein [OS=Homo sapiens]",29,5,14,5,114,12.8,5.25,36.43,"","nucleus;other cell component","other molecular function","SH3BGRL","ENSG00000131171","","","",2608.2,2921.6,2625.7,2685.8,2709.4,3673.7,0.8992821621144789,-0.15315424275820969,0.4223312693148022,0.37434676231621095,0.5953364025885997,0.22523756115729773,5185]
["O75369-1","Filamin-B [OS=Homo sapiens]",14,31,65,20,2602,278,5.73,163.33,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","FLNB","ENSG00000136068","MAPK signaling pathway; Focal adhesion; Salmonella infection; Proteoglycans in cancer","ISG15 antiviral mechanism","Focal adhesion; MAPK signaling pathway; VEGFA-VEGFR2 signaling pathway; Ebola virus pathway in host",1777.2,1770,1879.5,1703.7,1659.4,6930.7,0.527181410169228,-0.9236285969418588,0.40639460671835687,0.3910520642280719,0.5849425325924519,0.23288679888180236,5078]
["O75376-1","Nuclear receptor corepressor 1 [OS=Homo sapiens]",8,21,29,21,2440,270,7.11,79.66,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","NCOR1","ENSG00000141027","Endocrine resistance; Thyroid hormone signaling pathway; Transcriptional misregulation in cancer","HDACs deacetylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Transcriptional activation of mitochondrial biogenesis; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Nuclear Receptor transcription pathway; Cytoprotection by HMOX1; Nuclear signaling by ERBB4; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NR1D1 (REV-ERBA) represses gene expression; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis","Androgen receptor signaling pathway; Adipogenesis; Ovarian infertility; MECP2 and associated Rett syndrome; Pathways affected in adenoid cystic carcinoma; Rett syndrome causing genes; 22q11.2 copy number variation syndrome; Notch signaling pathway (Netpath)",3193.8,3193.2,3060.7,3943.6,3983.5,6022,0.6772981769433154,-0.5621369823697395,0.0945384488647237,1.024391527641499,0.31667347513852684,0.49938831200984923,2182]
["O75379-1","Vesicle-associated membrane protein 4 [OS=Homo sapiens]",32,3,4,3,141,16.4,7.34,8.97,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","VAMP4","ENSCATG00000035773; ENSG00000117533; ENSGGOG00000023200; ENSMFAG00000031870; ENSMLEG00000033096; ENSMMUG00000023203; ENSMNEG00000025169; ENSNLEG00000015204; ENSPANG00000022546; ENSPPAG00000028975; ENSPTRG00000001680; ENSRBIG00000031656; ENSRROG00000036404","SNARE interactions in vesicular transport","Retrograde transport at the Trans-Golgi-Network; Cargo recognition for clathrin-mediated endocytosis","",136.4,127.7,134.7,160.8,199,176,0.744307577454274,-0.4260291714441831,0.016138496811063094,1.792136919246089,0.13208989159245257,0.8791304162506623,893]
["O75380","NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [OS=Homo sapiens]",29,3,4,3,124,13.7,8.28,14.58,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity;other molecular function","NDUFS6","ENSG00000145494","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",91.5,82,93.1,120.1,111.9,121.9,0.7533201469341624,-0.4086649813362569,0.003282964276904213,2.483733842956857,0.06331183614747465,1.1985150910409563,379]
["O75381-1","Peroxisomal membrane protein PEX14 [OS=Homo sapiens]",41,12,27,12,377,41.2,4.94,82.63,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","PEX14","ENSG00000142655; ENSMFAG00000032533; ENSMMUG00000019979; ENSPANG00000017539; ENSPPAG00000038193; ENSPTRG00000000132","Peroxisome","Peroxisomal protein import; E3 ubiquitin ligases ubiquitinate target proteins; Class I peroxisomal membrane protein import","",2789.6,2797.8,2873,3134.3,3222.8,3408.4,0.8663560493574318,-0.20696803867056876,0.006899125199722303,2.1612059737582663,0.08924903731817754,1.0493964596937317,565]
["O75385","Serine/threonine-protein kinase ULK1 [OS=Homo sapiens]",2,2,2,2,1050,112.6,8.79,1.95,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","ULK1","ENSG00000177169","Mitophagy; Autophagy; mTOR signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration","RAB GEFs exchange GTP for GDP on RABs; Macroautophagy; TBC/RABGAPs; Receptor Mediated Mitophagy","Target of rapamycin (TOR) signaling; Alzheimer's disease and miRNA effects; Nanoparticle triggered autophagic cell death; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; 7q11.23 copy number variation syndrome; p53 transcriptional gene network; Malignant pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; Senescence and autophagy in cancer",277.4,253.4,266.7,242.8,233.8,384.4,0.9262485481997677,-0.11052871874461236,0.6895590294228289,0.16142855029264638,0.78175693284496,0.10692825861977913,6447]
["O75386","Tubby-related protein 3 [OS=Homo sapiens]",2,1,2,1,442,49.6,7.74,4.86,"developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","TULP3","ENSG00000078246","","Hedgehog 'off' state","H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Genes related to primary cilium development (based on CRISPR)",272.1,265.1,271.5,268.5,277.5,169.8,1.1297848561050572,0.17604806770082174,0.4210192459777995,0.3756980508842587,0.5944040310704533,0.22591825398214174,5177]
["O75390","citrate synthase, mitochondrial [OS=Homo sapiens]",41,17,151,17,466,51.7,8.32,428.26,"other metabolic processes","mitochondrion","other molecular function","CS","ENSG00000062485","Citrate cycle (TCA cycle); Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids","Citric acid cycle (TCA cycle); Mitochondrial protein import","TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Fluoroacetic acid toxicity; TCA cycle (aka Krebs or citric acid cycle)",21511.7,19683.1,21079.9,19051.1,18924.2,21812.9,1.0415884739798154,0.05878538911525934,0.4901657689880488,0.30965702123303923,0.641012990791492,0.19313316896497137,5589]
["O75396","Vesicle-trafficking protein SEC22b [OS=Homo sapiens]",38,7,51,7,215,24.6,6.92,195.73,"","","","","","","","",4524.3,4570.6,4766.3,4298,4549.9,4692.3,1.0237071830549032,0.03380311185538899,0.4786523632986371,0.31997979245952374,0.6333218905412271,0.19837550048214442,5524]
["O75398","Deformed epidermal autoregulatory factor 1 homolog [OS=Homo sapiens]",1,1,1,1,565,59.3,5.34,2.35,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;nucleus;other cell component","nucleic acid binding activity;other molecular function","DEAF1","ENSG00000177030","","","Sudden infant death syndrome (SIDS) susceptibility pathways",58.1,69.2,58.7,75.4,76.4,45.1,0.9446419502285424,-0.08216048990616001,0.7552960812563672,0.12188276857060786,0.8331510802750962,0.07927623823257608,6626]
["O75400","pre-mRNA-processing factor 40 homolog A [OS=Homo sapiens]",30,24,56,1,957,108.7,7.56,145.1,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","","PRPF40A","ENSG00000196504","Spliceosome","mRNA Splicing - Major Pathway","mRNA processing",101.3,86.5,101.6,106.6,107.9,152,0.7896316507503409,-0.3407482764894499,0.1776734369578308,0.7503774964769233,0.4205359944056947,0.3761968262566489,3088]
["O75400-3","Isoform 3 of Pre-mRNA-processing factor 40 homolog A [OS=Homo sapiens]",29,24,60,1,939,106.8,7.43,150.08,"","","","PRPF40A","","","","",8029.9,7812.1,8052,8218.2,7747.9,4604.7,1.1615493806755206,0.21605048840529698,0.38503840760256364,0.4144959474320112,0.5707251513216666,0.24357298807917593,4931]
["O75410-1","Transforming acidic coiled-coil-containing protein 1 [OS=Homo sapiens]",52,30,97,27,805,87.7,4.88,317.53,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","TACC1","ENSG00000147526","","","",9165.7,9274.4,8803.6,9714.8,10183.4,9163,0.9374595680839056,-0.09317162538637114,0.13795294250637835,0.8602690316787851,0.37609028600489347,0.4247078837776917,2681]
["O75414","Nucleoside diphosphate kinase 6 [OS=Homo sapiens]",17,3,7,3,186,21.1,8.32,21.18,"other metabolic processes;other biological processes","mitochondrion","kinase activity;other molecular function","NME6","ENSG00000172113","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors","","Pyrimidine metabolism",568.6,526.3,594.2,571.2,530.7,2026,0.5400108699127211,-0.8889396472198767,0.38505052277402035,0.414482282641092,0.5706273866494961,0.24364738868081307,4932]
["O75419","Cell division control protein 45 homolog [OS=Homo sapiens]",3,2,2,2,566,65.5,5.53,4.77,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","CDC45","ENSG00000093009","Cell cycle","Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA; G1/S-Specific Transcription","Cell cycle; Retinoblastoma gene in cancer; G1 to S cell cycle control; 22q11.2 copy number variation syndrome; DNA replication",188.7,178.9,202.6,218.6,205.9,347.2,0.738888168977582,-0.4365720664701098,0.21519211117143755,0.6671736537189924,0.461243149722005,0.3360700708275172,3410]
["O75420","GRB10-interacting GYF protein 1 [OS=Homo sapiens]",8,6,8,6,1035,114.5,5.39,22.65,"signal transduction","cytosol;other cell component","","GIGYF1","ENSG00000146830","","","",281.9,296.2,311.8,366.4,385.5,676.8,0.6228739413452788,-0.6829878780230486,0.14939613489436898,0.82566063823522,0.38721147161097264,0.4120517846706081,2820]
["O75427","Leucine-rich repeat and calponin homology domain-containing protein 4 [OS=Homo sapiens]",29,13,29,13,683,73.4,8.22,97.56,"developmental processes","nucleus","","LRCH4","ENSG00000077454","","","",1536.8,1621.3,1553.6,1491.8,1598.6,1369.7,1.0564112912266541,0.07917162663813211,0.30289736728073935,0.5187045014456727,0.527993526700435,0.277371401965268,4193]
["O75431","Metaxin-2 [OS=Homo sapiens]",39,7,29,7,263,29.7,6.29,115.23,"cell organization and biogenesis;transport","other membranes;mitochondrion;nucleus;other cell component","","MTX2","ENSG00000128654","","Mitochondrial protein import; Cristae formation","",1452.7,1437.7,1681.3,1666.1,1478.8,2193.3,0.8564122738001574,-0.2236226228167522,0.32510413557308726,0.48797750591098604,0.5438741421157461,0.2645015887365815,4369]
["O75436-1","Vacuolar protein sorting-associated protein 26A [OS=Homo sapiens]",51,14,42,12,327,38.1,6.57,115.45,"transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","VPS26A","ENSANAG00000022406; ENSCATG00000037809; ENSCCAG00000021117; ENSCJAG00000012907; ENSCSAG00000007798; ENSG00000122958; ENSMFAG00000042937; ENSMMUG00000004101; ENSMNEG00000039163; ENSNLEG00000011548; ENSPANG00000022152; ENSPPAG00000041182; ENSPPYG00000002386; ENSPTRG00000002567; ENSRBIG00000023684; ENSRROG00000006745; ENSSBOG00000030031","Endocytosis","WNT ligand biogenesis and trafficking","",4025.7,4313.3,4095,3823.6,3271.8,3597.8,1.162795047319792,0.2175968317446897,0.03332901604117334,1.4771775076475016,0.18957336828399682,0.7222226734308419,1285]
["O75438","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [OS=Homo sapiens]",19,1,3,1,58,7,8.92,7.18,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB1","ENSG00000183648","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",319.8,516.8,267,266.8,521.1,816.7,0.68777265362084,-0.5399963405665971,0.39675273489581553,0.40148007088422305,0.5778927340282016,0.23815276597884183,5018]
["O75439","mitochondrial-processing peptidase subunit beta [OS=Homo sapiens]",42,17,69,16,489,54.3,6.83,218.05,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport","other membranes;mitochondrion","other molecular function","PMPCB","ENSG00000105819","","Mitochondrial protein import; Processing of SMDT1","",6796.2,6720.2,7161.3,6338.3,5830.4,6872,1.0859737299574068,0.11898920432222689,0.17366601583227348,0.760285158988172,0.41508335831199705,0.38186467818050024,3058]
["O75448","Mediator of RNA polymerase II transcription subunit 24 [OS=Homo sapiens]",14,10,14,10,989,110.2,6.95,41.37,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","MED24","ENSG00000008838","Thyroid hormone signaling pathway","Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","",925.3,899.5,961.4,891.1,956.1,840,1.0368413218219708,0.05219512102006253,0.43516818107747945,0.36134286718778097,0.605145402491495,0.21814026185553237,5256]
["O75449-1","Katanin p60 ATPase-containing subunit A1 [OS=Homo sapiens]",15,8,11,7,491,55.9,6.9,16.05,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KATNA1","ENSG00000186625","","","",1347.3,1347.5,1438.7,1414.4,1283.5,1140.5,1.0768809920800333,0.1068588240486891,0.31031081559748674,0.5082030872181271,0.5337871855029491,0.2726318564236685,4249]
["O75460","Serine/threonine-protein kinase/endoribonuclease IRE1 [OS=Homo sapiens]",22,15,31,15,977,109.7,6.42,111.1,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","ERN1","ENSG00000178607","Autophagy; Protein processing in endoplasmic reticulum; Apoptosis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Lipid and atherosclerosis","IRE1alpha activates chaperones","Alzheimer's disease and miRNA effects; Corticotropin-releasing hormone signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling pathway; Nonalcoholic fatty liver disease; Unfolded protein response; Alzheimer's disease",1961.1,2031.2,2058.4,2940.8,3198.4,4318.1,0.5786101574976333,-0.7893364448952805,0.025668855943910798,1.590593487320718,0.16602979477349028,0.7798139689201647,1130]
["O75475-1","PC4 and SFRS1-interacting protein [OS=Homo sapiens]",51,28,82,27,530,60.1,9.13,247.61,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PSIP1","ENSG00000164985; ENSGGOG00000016152; ENSPTRG00000020786","","Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection","MECP2 and associated Rett syndrome",11389,11376.4,11319.5,11971.4,12573.7,10714.8,0.9666760257402888,-0.04889563266328526,0.5142802920843725,0.28880011811134565,0.6595674074126476,0.18074081320120328,5699]
["O75477","erlin-1 [OS=Homo sapiens]",27,10,23,7,346,38.9,7.87,65.26,"","","","","","","","",1846.6,1847.2,1835.6,1796.5,1707.4,2433.8,0.9312360004715629,-0.10278126269587377,0.5839100401252526,0.23365405714551507,0.7085835104226251,0.14960895843212257,6023]
["O75487","Glypican-4 [OS=Homo sapiens]",10,4,7,4,556,62.4,6.68,26.89,"cell adhesion;cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes","extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","GPC4","ENSG00000076716","Wnt signaling pathway","A tetrasaccharide linker sequence is required for GAG synthesis; HS-GAG biosynthesis; HS-GAG degradation; Defective B4GALT7 causes EDS, progeroid type; Defective B3GAT3 causes JDSSDHD; Defective EXT2 causes exostoses 2; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Defective B3GALT6 causes EDSP2 and SEMDJL1; Retinoid metabolism and transport","Wnt signaling",660.5,692.7,648.9,775.3,921.1,793.6,0.8040562248995984,-0.3146317072298022,0.027022548282255174,1.5682736985139205,0.1707068326663812,0.7677490955816971,1157]
["O75489","NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [OS=Homo sapiens]",63,16,72,16,264,30.2,7.5,211.44,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion;nucleus","transporter activity;other molecular function","NDUFS3","ENSG00000213619; ENSG00000285387","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","RHOG GTPase cycle; Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",8433.9,8188.9,8500.6,8658.4,8690.6,6648.9,1.0468999370778276,0.06612355575452016,0.6114652012247586,0.21362825382981807,0.7259907660415466,0.1390689031052862,6156]
["O75494-1","Serine/arginine-rich splicing factor 10 [OS=Homo sapiens]",30,10,43,10,262,31.3,11.27,118.09,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","Srsf10; SRSF10","ENSCATG00000031598; ENSCCAG00000022497; ENSCPOG00000034102; ENSG00000188529; ENSGGOG00000000392; ENSMLEG00000016013; ENSMNEG00000041500; ENSMUSG00000028676; ENSNLEG00000027520; ENSPANG00000021680; ENSPCOG00000022379; ENSPCTG00005007467; ENSPPAG00000032557; ENSPPYG00000001726; ENSPTRG00000044753; ENSRBIG00000028456; ENSRFEG00010001865; ENSRROG00000043248; ENSSBOG00000019550; ENSSSCG00070027414; ENSSTOG00000000956; ENSTSYG00000009439","Spliceosome","mRNA Splicing - Major Pathway; mRNA Splicing - Major Pathway","mRNA processing; mRNA processing; mRNA Processing",6905.9,6679.7,6849.7,6696.7,7399.6,7740.8,0.9358064944521022,-0.09571785392013984,0.21189537767157157,0.673878516973138,0.4569912408974673,0.34009212392654337,3389]
["O75503","Ceroid-lipofuscinosis neuronal protein 5 [OS=Homo sapiens]",13,3,4,3,358,41.5,7.4,11.35,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CLN5","ENSG00000102805","Lysosome","","",123.1,113.4,113.9,90.4,99.1,128.5,1.1018867924528302,0.13997600942945568,0.41724369257465876,0.3796102197792736,0.5920470101005981,0.2276438077758796,5151]
["O75521","Enoyl-CoA delta isomerase 2, mitochondrial [OS=Homo sapiens]",48,13,45,13,394,43.6,9,154.73,"other metabolic processes","cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","ECI2","ENSG00000198721","Fatty acid degradation; Peroxisome","","",3733.3,3859.7,3865.7,3618.1,3693.1,3085.9,1.1021053947735426,0.14026219600205853,0.1452290363799643,0.83794654424967,0.3822394767379038,0.41766446211595465,2777]
["O75525-1","KH domain-containing, RNA-binding, signal transduction-associated protein 3 [OS=Homo sapiens]",9,4,17,2,346,38.8,7.61,34.39,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KHDRBS3","ENSCCAG00000031191; ENSG00000131773; ENSGGOG00000000940; ENSRBIG00000036854; ENSRROG00000044792","","PTK6 Regulates Proteins Involved in RNA Processing","",97.4,110.3,96.3,126.9,130.9,228.7,0.6248715313463515,-0.6783684813375259,0.14435900147603506,0.8405561305952667,0.38173659254281483,0.41823620741345446,2764]
["O75530","Polycomb protein EED [OS=Homo sapiens]",20,7,11,7,441,50.2,7.03,34.57,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","EED","ENSG00000074266","","Transcriptional Regulation by E2F6; HCMV Early Events; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; PKMTs methylate histone lysines; PRC2 methylates histones and DNA; Defective pyroptosis","Histone modifications; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Malignant pleural mesothelioma",1141.8,1106.6,1184.8,1224,1058,1029.6,1.0367194105568305,0.052025479711657496,0.5649950856300869,0.24795532969032666,0.6953273414497904,0.15781069308337536,5939]
["O75531","Barrier-to-autointegration factor [OS=Homo sapiens]",30,3,4,3,89,10.1,6.09,5.01,"cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","BANF1","ENSG00000175334","","Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Nuclear Envelope Breakdown; Initiation of Nuclear Envelope (NE) Reformation","Envelope proteins and their potential roles in EDMD physiopathology; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy",213.1,244.2,243.1,227.2,247.3,164.6,1.0959161320607105,0.1321373963917318,0.4898821543825552,0.30990838090363126,0.6408714276681754,0.19322909037982278,5587]
["O75533-1","splicing factor 3B subunit 1 [OS=Homo sapiens]",49,53,229,53,1304,145.7,7.09,699.58,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","LOC101357717; LOC111145177; Sf3b1; SF3B1","ENSANAG00000021577; ENSCANG00000029415; ENSCATG00000035735; ENSCCAG00000020506; ENSCGRG00001016990; ENSCGRG00015028775; ENSCJAG00000003902; ENSCSAG00000011505; ENSDLEG00000016863; ENSFCAG00000005038; ENSG00000115524; ENSLAFG00000001956; ENSLCNG00005009987; ENSMMNG00015005194; ENSMMUG00000022430; ENSMNEG00000042333; ENSMPUG00000007799; ENSMUSG00000025982; ENSNLEG00000006861; ENSPANG00000013417; ENSPCTG00005000567; ENSPPAG00000035007; ENSRNOG00000013516; ENSRROG00000031308; ENSSBOG00000020080; ENSSSCG00000016075; ENSSSCG00070023758; ENSSSUG00005005995; ENSSTOG00000011034; ENSUMAG00000020945","Spliceosome","B-WICH complex positively regulates rRNA expression; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; mRNA Splicing - Major Pathway; B-WICH complex positively regulates rRNA expression; mRNA Splicing - Minor Pathway; mRNA Splicing - Major Pathway; B-WICH complex positively regulates rRNA expression; mRNA Splicing - Minor Pathway","mRNA processing; mRNA processing; mRNA processing",26001.9,25517.6,25899.7,30282.9,29921.9,30516.4,0.8533749553577331,-0.22874832359299174,4.0657264508127173E-5,4.390861844807435,0.010612998081782196,1.9741619142656812,28]
["O75534","cold shock domain-containing protein E1 [OS=Homo sapiens]",39,32,122,32,798,88.8,6.25,346.46,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","nucleic acid binding activity","CSDE1","ENSG00000009307","","","",19011.6,19283.5,18595.8,22128.8,21274.5,18451.9,0.9197432067150375,-0.12069697949201633,0.21654735440286224,0.6644471177538425,0.46225017912690425,0.3351229118749851,3424]
["O75554","WW domain-binding protein 4 [OS=Homo sapiens]",5,2,2,2,376,42.5,5.57,5.48,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","WBP4","ENSG00000120688","","mRNA Splicing - Major Pathway","",283.7,268.5,264.9,347.1,344.6,448.2,0.7168172646723396,-0.48032270950466355,0.03590042088005594,1.444900459922673,0.19655144285567702,0.706523763739294,1335]
["O75558","syntaxin-11 [OS=Homo sapiens]",5,1,4,1,287,33.2,6.55,17.41,"cell-cell signaling;cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","STX11","ENSG00000135604","SNARE interactions in vesicular transport","","",206.7,225.8,218.7,201.2,219,241.1,0.9847270527748376,-0.022204201970284027,0.8057621705045713,0.09379312603522517,0.8687587703522514,0.0611007980606947,6779]
["O75569-1","Interferon-inducible double-stranded RNA-dependent protein kinase activator A [OS=Homo sapiens]",29,8,30,8,313,34.4,8.41,86.74,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;kinase activity;other molecular function","PRKRA","ENSCATG00000032736; ENSG00000180228; ENSMNEG00000031681; ENSPANG00000001046; ENSPTRG00000012688","","MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis","VEGFA-VEGFR2 signaling pathway; Ebola virus pathway in host",3587.1,3572.6,3677.2,3353.5,3310.7,3951.7,1.0208178298589852,0.02972543290712625,0.7428259476625247,0.12911293432128118,0.8222497124739351,0.08499626971031862,6603]
["O75570","Peptide chain release factor 1, mitochondrial [OS=Homo sapiens]",6,2,3,2,445,52.3,8.5,7.44,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","mitochondrion","nucleic acid binding activity","MTRF1","ENSG00000120662","","","",200.5,190.1,198.6,159,187.2,79.5,1.3840732910500353,0.4689203402541418,0.16786844757765707,0.7750309258431315,0.4093928873357009,0.3878597069048032,2997]
["O75582-1","Ribosomal protein S6 kinase alpha-5 [OS=Homo sapiens]",3,2,2,2,802,89.8,7.11,4.81,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","kinase activity;other molecular function","RPS6KA5","ENSG00000100784; ENSGGOG00000004254; ENSPPAG00000038077; ENSPTRG00000006631","MAPK signaling pathway; Adrenergic signaling in cardiomyocytes; TNF signaling pathway; Circadian entrainment; Neurotrophin signaling pathway; Shigellosis; Pathways in cancer; MicroRNAs in cancer; Bladder cancer","Recycling pathway of L1; NCAM signaling for neurite out-growth; ERK/MAPK targets; CREB phosphorylation; CD209 (DC-SIGN) signaling","Brain-derived neurotrophic factor (BDNF) signaling pathway; Interleukin-1 (IL-1) structural pathway; Bladder cancer; MAPK signaling pathway; ERK pathway in Huntington's disease; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; p38 MAPK signaling pathway; EGF/EGFR signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Insulin signaling; Malignant pleural mesothelioma; Interferon type I signaling pathways; Serotonin receptor 4/6/7 and NR3C signaling; EGFR1 signaling pathway; MAPK signaling pathway; p38 MAPK signaling pathway",94.4,90.3,86.5,96.9,107.3,78.4,0.959660297239915,-0.059404287197595634,0.686602273201465,0.163294763046566,0.7793719544695616,0.10825522625471734,6439]
["O75586","Mediator of RNA polymerase II transcription subunit 6 [OS=Homo sapiens]",13,4,4,4,246,28.4,8.62,8.85,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MED6","ENSG00000133997","","Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","",706.6,742.7,727.6,761.2,780.3,433.3,1.1023394774154345,0.14056858594371263,0.583494619125742,0.2339631445796619,0.7083145941189252,0.1497738099028369,6021]
["O75592-1","E3 ubiquitin-protein ligase MYCBP2 [OS=Homo sapiens]",18,71,138,1,4640,509.8,7.03,376.42,"","","","","","","","",93.1,107.7,87.5,92.7,85.7,60.1,1.208805031446541,0.2735815706020329,0.22547747341357202,0.6468968403087038,0.47166996370343384,0.326361779071643,3494]
["O75592-2","Isoform 2 of E3 ubiquitin-protein ligase MYCBP2 [OS=Homo sapiens]",18,71,138,1,4637,509.4,7.03,374.77,"","","","","","","","",14251.1,13983.9,14204.8,14164.2,14023.6,17951.4,0.919820889829039,-0.12057513210044361,0.3929512666665083,0.4056613069532524,0.5749911527658678,0.24033883763128053,4995]
["O75607","Nucleoplasmin-3 [OS=Homo sapiens]",44,5,34,5,178,19.3,4.63,111.29,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","NPM3","ENSG00000107833","","","",2544.4,2560.8,2723.2,2851.6,2587.8,2784.3,0.9519316122913043,-0.07107016227023373,0.24819284749075785,0.605210738308902,0.4912108102653531,0.3087320840759078,3693]
["O75608","Acyl-protein thioesterase 1 [OS=Homo sapiens]",49,8,37,8,230,24.7,6.77,117.04,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","LYPLA1","ENSG00000120992","Glycerophospholipid metabolism; Choline metabolism in cancer","RAS processing; eNOS activation","",4949.7,4846.2,4801.5,4325.1,4437.5,4005.5,1.1432711209968593,0.1931675719994237,0.011138529111532534,1.9531721557440724,0.11106617909439467,0.9544181685012273,733]
["O75616-1","GTPase Era, mitochondrial [OS=Homo sapiens]",24,7,15,7,437,48.3,8.84,51.11,"cell organization and biogenesis","other membranes;cytosol;mitochondrion","translation activity;nucleic acid binding activity;other molecular function","ERAL1","ENSG00000132591","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Integrated breast cancer pathway",1280,1342,1318,1177.6,1257.3,1558,0.986751483883894,-0.019241311232297116,0.8877092261446743,0.051729266384321945,0.9280885043472213,0.03241060662935688,6991]
["O75626-1","PR domain zinc finger protein 1 [OS=Homo sapiens]",5,4,9,3,825,91.7,8.48,18.45,"cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","PRDM1","ENSG00000057657","","STAT3 nuclear events downstream of ALK signaling; Regulation of TP53 Expression","Nucleotide-binding oligomerization domain (NOD) pathway; Vitamin D receptor pathway; IL-6 signaling pathway; Overview of leukocyte-intrinsic Hippo pathway functions",256,259,276.4,561.4,636.4,576.9,0.44593452414492596,-1.1650961978043466,1.591612612857367E-4,3.7981626279117693,0.01710749498143308,1.7668135787340327,68]
["O75643-1","U5 small nuclear ribonucleoprotein 200 kDa helicase [OS=Homo sapiens]",42,80,293,79,2136,244.4,6.06,888.7,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","SNRNP200","ENSCATG00000015790; ENSG00000144028; ENSGGOG00000005174; ENSMLEG00000019083; ENSPPAG00000041559; ENSPPYG00000012068; ENSPTRG00000012230; ENSRBIG00000044690; ENSRROG00000037952","Spliceosome","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","",34331.6,34453.8,34028.9,35500,35005.1,29160.1,1.0315967860396604,0.04487918350162348,0.6339464393501186,0.19794743309192767,0.7421935808441482,0.12948280613924404,6243]
["O75648-1","Mitochondrial tRNA-specific 2-thiouridylase 1 [OS=Homo sapiens]",33,12,22,12,421,47.7,8.03,61.55,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","nucleic acid binding activity;other molecular function","TRMU","ENSG00000100416","","tRNA modification in the mitochondrion","",1706.8,1709.9,1856.6,1629.2,1459.8,1880,1.0612396860535318,0.0857505326223859,0.4841074654288475,0.31505822004542633,0.6366213502733801,0.19611880060280648,5558]
["O75663","TIP41-like protein [OS=Homo sapiens]",33,9,38,9,272,31.4,5.91,107.7,"stress response;signal transduction;other biological processes","cytosol","","TIPRL","ENSG00000143155","","","Ciliary landscape",5162.3,5146.6,5445,5484.6,5165.1,4674,1.028074159635075,0.03994433639836455,0.6037604722596812,0.21913532331264787,0.7209418872318265,0.14209974092786232,6121]
["O75665","Oral-facial-digital syndrome 1 protein [OS=Homo sapiens]",4,4,4,4,1012,116.6,6.1,14.19,"cell organization and biogenesis;transport;developmental processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","OFD1","ENSG00000046651","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Hedgehog 'off' state","Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies",302.1,287.5,327.8,387.9,309.6,310.8,0.9098482594465934,-0.1363021359471969,0.3469596885782341,0.4597209806702674,0.5532129938521626,0.257107627745628,4584]
["O75674","TOM1-like protein 1 [OS=Homo sapiens]",5,1,2,1,476,53,5.24,10.18,"protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","TOM1L1","ENSG00000141198","","","",42.6,37.5,45.2,43.3,65.3,97.7,0.6073679108095007,-0.7193574065646242,0.1659629145870343,0.7799889468368506,0.40870045239778763,0.38859488155986716,2968]
["O75676","Ribosomal protein S6 kinase alpha-4 [OS=Homo sapiens]",9,7,8,7,772,85.6,8.28,21.95,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","RPS6KA4","ENSG00000162302","MAPK signaling pathway; TNF signaling pathway","Recycling pathway of L1","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Translation inhibitors in chronically activated PDGFRA cells; Insulin signaling; Interferon type I signaling pathways",701.6,673.3,713.3,628.6,711.3,819,0.9672518412154337,-0.04803652496935166,0.6974428850727503,0.15649135180112198,0.7871541147308111,0.1039402299984851,6476]
["O75683","Surfeit locus protein 6 [OS=Homo sapiens]",17,3,6,3,361,41.4,10.64,16.61,"other biological processes","nucleus;other cell component","nucleic acid binding activity","SURF6","ENSG00000148296; ENSG00000281309","","","",37.7,42.8,41.9,107.4,111.5,148,0.33360588716271466,-1.5837833465558908,0.003303444315976471,2.4810330094150603,0.06337237403011031,1.1981000232067067,381]
["O75688","Protein phosphatase 1B [OS=Homo sapiens]",30,12,32,1,479,52.6,5.05,85.91,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;nucleus","other molecular function","PPM1B","ENSG00000138032","MAPK signaling pathway","ISG15 antiviral mechanism; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants","MAPK signaling pathway",2621.1,2543.6,2753.2,2757.5,2841.6,2556.3,0.9708781911371606,-0.04263779210165114,0.49064996234962543,0.30922823014523243,0.641072680517235,0.1930927302967679,5594]
["O75688-2","Isoform Beta-2 of Protein phosphatase 1B [OS=Homo sapiens]",36,12,32,1,387,42.7,5.2,78.89,"","","","PPM1B","","","","",193.1,175.8,176.3,193.8,197.4,280.3,0.8119136262099776,-0.30060183750959524,0.21784977935757383,0.6618428755897682,0.46367619025174933,0.3337852045306929,3434]
["O75691","Small subunit processome component 20 homolog [OS=Homo sapiens]",11,23,31,23,2785,318.2,7.39,92.85,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;nucleus;other cell component","","UTP20","ENSG00000120800","","rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol","",2705.5,2711.5,2681.3,5034.3,5337.5,4439.7,0.5467575870100935,-0.8710267601061875,1.0594962041549528E-3,2.9749005948923193,0.039916792557569844,1.3988443629385725,194]
["O75694","nuclear pore complex protein nup155 [OS=Homo sapiens]",25,26,67,26,1391,155.1,6.16,198.87,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus","other molecular function","NUP155","ENSG00000113569","Nucleocytoplasmic transport; Amyotrophic lateral sclerosis","HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation","",6147,6169.5,6210.3,5660,5298.9,4918.9,1.1668367154139743,0.2226026875711303,0.0147135207189232,1.8322833948557764,0.1259263734597303,0.8998833036608084,854]
["O75695","Protein XRP2 [OS=Homo sapiens]",31,9,25,9,350,39.6,5.12,60.43,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","RP2","ENSG00000102218","","Trafficking of myristoylated proteins to the cilium","Joubert syndrome; Ciliopathies",2425.6,2402.1,2484.3,2028.4,2125.4,2211,{"$f":"AVERAGE(S642:U642)/AVERAGE(V642:X642)","v":1.1488185017596784},{"$f":"LOG(Y642,2)","v":0.2001508891116883},{"$f":"TTEST(V642:X642,S642:U642,2,2)","v":0.00557598800552191},2.2536781691175882,{"$f":"AA642*7309/AE642","v":0.08200180348563307},1.0861765959669476,497]
["O75717","WD repeat and HMG-box DNA-binding protein 1 [OS=Homo sapiens]",16,12,13,12,1129,125.9,5.62,27.54,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response","nucleus;other cell component","nucleic acid binding activity;other molecular function","WDHD1","ENSG00000198554","","","Mesodermal commitment pathway",1187.5,1179.2,1169.4,1235.9,1365.9,1920.1,0.7819942944337558,-0.3547700134700222,0.19243357963244861,{"$f":"-LOG10(AA643)","v":0.7157191413595476},0.4385709490282404,{"$f":"-LOG10(AC643)","v":0.35796013940401505},3207]
["O75718","Cartilage-associated protein [OS=Homo sapiens]",17,6,7,6,401,46.5,5.73,22.1,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;ER/Golgi;other cell component","","CRTAP","ENSG00000170275","","Collagen biosynthesis and modifying enzymes","Type I collagen synthesis in the context of osteogenesis imperfecta",414.6,419.5,433.7,425.9,421.3,758.5,0.7895621847169458,-0.34087519985972037,0.3706668877772181,0.4310162084078043,0.5623089005321061,0.2500250421861559,4818]
["O75746","Calcium-binding mitochondrial carrier protein Aralar1 [OS=Homo sapiens]",27,17,28,12,678,74.7,8.38,83.01,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","SLC25A12","ENSG00000115840","","Mitochondrial protein import; Gluconeogenesis; Aspartate and asparagine metabolism","",3825.1,3765.1,3881,3441.1,3498,5925.1,0.8917149919932837,-0.1653454221196685,0.6012050385817058,0.2209773883328642,0.7187124021906588,0.14344486083896127,6114]
["O75787","Renin receptor [OS=Homo sapiens]",12,3,6,3,350,39,6.1,20.4,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ATP6AP2","ENSG00000182220","Renin-angiotensin system","Neutrophil degranulation; Metabolism of Angiotensinogen to Angiotensins","ACE inhibitor pathway; Oxidative phosphorylation",241.1,248.1,243.4,217.2,219.8,699.8,0.6444405348346235,-0.633880853534221,0.4483185361057608,0.3484133044935079,0.6135106123192297,0.21217792057867219,5341]
["O75792","Ribonuclease H2 subunit A [OS=Homo sapiens]",25,7,14,7,299,33.4,5.25,47.15,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RNASEH2A","ENSG00000104889","DNA replication","","",1126.5,1069.4,1165.8,1261.8,1300.3,1489,0.8298239984201822,-0.26912271449011155,0.038375910365784284,1.4159413089180906,0.20354827929137687,0.6913325646057246,1378]
["O75794","Cell division cycle protein 123 homolog [OS=Homo sapiens]",24,6,16,6,336,39.1,4.81,41.87,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","other cell component","","CDC123","ENSG00000151465","","","",762,753.8,791,1634.7,1621,1726.7,0.4629897238278742,-1.1109479220219167,1.4170029569707194E-5,4.848629243475386,0.010356874612498988,1.9847712815914131,10]
["O75795","UDP-glucuronosyltransferase 2B17 [OS=Homo sapiens]",11,6,14,6,530,61.1,8.54,31.24,"other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","UGT2B17","ENSG00000197888","Pentose and glucuronate interconversions; Ascorbate and aldarate metabolism; Steroid hormone biosynthesis; Retinol metabolism; Porphyrin and chlorophyll metabolism; Metabolism of xenobiotics by cytochrome P450; Drug metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors; Bile secretion; Chemical carcinogenesis; Chemical carcinogenesis","Glucuronidation","Glucuronidation; Metapathway biotransformation Phase I and II",1015.9,1016.3,1048.3,1013,962.9,3682.9,0.5443733653778186,-0.8773316132352963,0.3929746913246932,0.40563541850997165,0.5749103320440718,0.24039988632809653,4996]
["O75808-1","Calpain-15 [OS=Homo sapiens]",5,3,3,3,1086,117.2,6.71,12.14,"protein metabolism","other cell component","other molecular function","CAPN15","ENSG00000103326","","Degradation of the extracellular matrix","",114,126.2,134.7,138.4,142.6,210.4,0.762922262922263,-0.39039203207407436,0.18228862935447143,0.7392404205530392,0.42567015717310913,0.3709267962155148,3130]
["O75817","Ribonuclease P protein subunit p20 [OS=Homo sapiens]",11,1,3,1,140,15.6,8.94,12.21,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POP7","ENSG00000172336","Ribosome biogenesis in eukaryotes","tRNA processing in the nucleus","",266.2,293.6,268.3,335.9,323.8,584.1,0.6657822801093422,-0.5868776214331788,0.17951128344693343,0.7459082480063985,0.4222877279413056,0.37439153937740005,3107]
["O75818-1","Ribonuclease P protein subunit p40 [OS=Homo sapiens]",8,2,3,2,363,41.8,6.67,14.23,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RPP40","ENSG00000124787","Ribosome biogenesis in eukaryotes","tRNA processing in the nucleus; Major pathway of rRNA processing in the nucleolus and cytosol","",472.1,469.6,482.4,446.8,487,501,0.9925425146361863,-0.01079919480693621,0.8414149966512078,0.0749897517618255,0.8932319840992995,0.04903573447079506,6885]
["O75820-1","Zinc finger protein 189 [OS=Homo sapiens]",7,3,6,1,626,72.9,8.5,8.26,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF189","ENSG00000136870; ENSGGOG00000003650; ENSPPAG00000034345; ENSPPYG00000019452; ENSPTRG00000021200","Herpes simplex virus 1 infection","Generic Transcription Pathway","",11.7,12.4,18.8,18.5,15.2,19.3,0.809433962264151,-0.30501471195101587,0.2625769121107474,0.5807434632568719,0.501351789607485,0.2998574304777049,3828]
["O75821","Eukaryotic translation initiation factor 3 subunit G [OS=Homo sapiens]",57,20,77,20,320,35.6,6.13,246.58,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity","EIF3G","ENSG00000130811","","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell",8585.1,8480.3,8759.7,10523.9,10441.8,9435.6,0.8494735422498382,-0.23535908103804906,0.013199598961592056,1.8794392635981976,0.11984579976431843,0.9213771820820932,805]
["O75822","Eukaryotic translation initiation factor 3 subunit J [OS=Homo sapiens]",32,9,27,9,258,29,4.83,70.19,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3J","ENSG00000104131","","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell",5479.3,2691.7,1785,4235.1,2742.7,1239.7,1.2115606936416186,0.27686667901336337,0.7018062208829361,0.15378278647234017,0.7900048773191714,0.10237022746112319,6493]
["O75828","Carbonyl reductase [NADPH] 3 [OS=Homo sapiens]",43,10,31,6,277,30.8,6.18,97.68,"other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","CBR3","ENSG00000159231","Arachidonic acid metabolism; Metabolism of xenobiotics by cytochrome P450; Metabolic pathways","Phase I - Functionalization of compounds","Nuclear receptors meta-pathway; NRF2 pathway",1117.7,1087.1,1088.6,986.2,1054.3,967.3,1.094953121883104,0.13086910519221365,0.027997642314843047,1.5528785391136788,0.17386131493558865,0.7597970400731405,1177]
["O75832","26S proteasome non-ATPase regulatory subunit 10 [OS=Homo sapiens]",54,9,38,9,226,24.4,6.1,130.27,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","PSMD10","ENSG00000101843","","Degradation of DVL; Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Parkin-ubiquitin proteasomal system pathway",3926.2,4137.2,3837.9,3896.7,3581.6,7583.3,0.7901750146066819,-0.3397558659761348,0.4592379171286429,0.337962261463936,0.6202087834983834,0.20746208750554843,5412]
["O75843","AP-1 complex subunit gamma-like 2 [OS=Homo sapiens]",5,4,6,4,785,87.1,6.55,14.17,"transport","other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","AP1G2","ENSG00000213983","Lysosome; Human immunodeficiency virus 1 infection","Lysosome Vesicle Biogenesis","",491.5,478,451.4,534.2,524.9,860.7,0.7401291801229296,-0.4341509981217928,0.20858484644487124,0.6807172459786365,0.4538691999599774,0.3430692879363278,3359]
["O75844","caax prenyl protease 1 homolog [OS=Homo sapiens]",31,14,57,14,475,54.8,7.49,155.37,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZMPSTE24","ENSG00000084073","Terpenoid backbone biosynthesis","","Adipogenesis; Lamin A-processing pathway; Nephrotic syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy",7228.5,7225.9,7430.5,5900.9,6486.7,3979.5,1.337127530228324,0.41913707085660645,0.0728190001836854,1.1377552882926167,0.27534095827343846,0.5601291804371968,1933]
["O75865-1","Trafficking protein particle complex subunit 6A [OS=Homo sapiens]",6,1,1,1,159,17.6,5.26,2.3,"cell organization and biogenesis;transport;other biological processes","cytosol;ER/Golgi;other cell component","","TRAPPC6A","ENSG00000007255","","RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport","",32.9,26.2,35.8,32.7,26.5,20.4,1.1922110552763818,0.25363965647746045,0.3249450039958624,0.48819013588942634,0.5437323796258604,0.2646148037021342,4368]
["O75874","Isocitrate dehydrogenase [NADP] cytoplasmic [OS=Homo sapiens]",52,22,138,21,414,46.6,7.01,357.16,"other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","IDH1","ENSG00000138413","Citrate cycle (TCA cycle); Glutathione metabolism; Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids; Peroxisome; Central carbon metabolism in cancer","Peroxisomal protein import; Neutrophil degranulation; Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate; NADPH regeneration","Glutathione metabolism; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism",17108.5,16534.5,16619.9,16471.9,16563,15304.6,1.0397894061792117,0.05629136161041721,0.22124519588644168,0.6551261507890552,0.4668248085259822,0.3308460722503913,3464]
["O75879","Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial [OS=Homo sapiens]",11,5,11,5,557,61.8,8.63,26.29,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","other molecular function","GATB","ENSG00000059691","Aminoacyl-tRNA biosynthesis; Metabolic pathways","","",767.1,777.5,842.8,777.3,836.9,765.8,1.0031092436974787,0.004478731332225012,0.9428896373130824,0.025539137284792467,0.9629146792121446,0.016412192614761775,7157]
["O75880","Protein SCO1 homolog, mitochondrial [OS=Homo sapiens]",5,2,5,2,301,33.8,8.88,12.22,"cell organization and biogenesis;other biological processes","other membranes;cytoskeleton;mitochondrion","other molecular function","SCO1","ENSG00000133028","","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis",908.7,1010.3,913.5,968.9,1023.5,703.3,1.0507474867381386,0.07141600574065071,0.6845009054991396,0.1646259730186405,0.7785585307023359,0.10870873235016681,6426]
["O75882-1","Attractin [OS=Homo sapiens]",1,3,3,3,1429,158.4,7.31,6.16,"cell adhesion;stress response;developmental processes;other biological processes","extracellular matrix;plasma membrane;other membranes;other cell component","other molecular function","ATRN","ENSG00000088812","","","",418.8,399.7,427.7,502.7,528.6,399.5,0.8709812692200168,-0.19928640142942153,0.20138888540875005,0.6959645017012017,0.4469940368820389,0.3496982705291365,3293]
["O75884-1","Putative hydrolase RBBP9 [OS=Homo sapiens]",16,3,3,3,186,21,6.2,8.55,"other biological processes","nucleus","other molecular function","RBBP9","ENSG00000089050; ENSPPAG00000038694; ENSPTRG00000013289","","","",454,617.4,431.9,629.3,542.8,1616.2,0.5391457160276871,-0.8912528490354569,0.2872617926321256,0.5417221336755875,0.5185469109281813,0.2852119485600279,4049]
["O75886","Signal transducing adapter molecule 2 [OS=Homo sapiens]",17,8,15,7,525,58.1,5.07,44.99,"cell organization and biogenesis;other metabolic processes;transport;signal transduction","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","STAM2","ENSG00000115145","Endocytosis; JAK-STAT signaling pathway","Ub-specific processing proteases; Endosomal Sorting Complex Required For Transport (ESCRT); RHOU GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell","EGF/EGFR signaling pathway",1123.9,1064,1020.5,1165.2,1212,1007.9,0.9478006558151902,-0.0773444356672227,0.4391036188009177,0.3574329837136639,0.6079576339867224,0.21612668383064937,5279]
["O75907","Diacylglycerol O-acyltransferase 1 [OS=Homo sapiens]",9,3,6,3,488,55.2,9.32,23.89,"cell organization and biogenesis;other metabolic processes;other biological processes","plasma membrane;other membranes;ER/Golgi","other molecular function","DGAT1","ENSG00000185000; ENSG00000285482","Glycerolipid metabolism; Retinol metabolism; Metabolic pathways; Fat digestion and absorption","Neutrophil degranulation; Acyl chain remodeling of DAG and TAG; Triglyceride biosynthesis","Triacylglyceride synthesis; Statin inhibition of cholesterol production; Glycerolipids and glycerophospholipids; Congenital generalized lipodystrophy (CGL); Vitamin A and carotenoid metabolism",435.4,420.6,520.5,416.8,415.5,494.6,1.037380360238149,0.052944961863113905,0.7050733882806894,0.15176567667305385,0.7920967406922163,0.10122177373491567,6506]
["O75909","Cyclin-K [OS=Homo sapiens]",12,5,9,5,580,64.2,8.41,32.68,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","CCNK","ENSG00000090061","","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; RNA polymerase II transcribes snRNA genes","Male infertility",606.3,606.7,660.6,628.6,647.2,576.7,1.0113900134952765,0.016339438420656292,0.8124285561051423,0.09021481995343189,0.873369659740033,0.058801899243569995,6799]
["O75915","PRA1 family protein 3 [OS=Homo sapiens]",28,6,74,6,188,21.6,9.77,239.08,"other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi","","ARL6IP5","ENSG00000144746","","Glutamate Neurotransmitter Release Cycle","",6972.4,6675.1,7066.4,6170.4,6535.6,8579.9,0.9731277512343853,-0.03929888189122459,0.8140229925781798,0.08936332802381733,0.8743121311908768,0.05833349567919781,6805]
["O75925","E3 SUMO-protein ligase PIAS1 [OS=Homo sapiens]",4,2,4,1,651,71.8,7.3,11.56,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PIAS1","ENSG00000033800","Ubiquitin mediated proteolysis; JAK-STAT signaling pathway; Hepatitis C","SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of transcription cofactors; SUMOylation of intracellular receptors; Regulation of IFNG signaling; SUMOylation of transcription factors; Formation of Incision Complex in GG-NER","Androgen receptor signaling pathway; Interleukin-11 signaling pathway; Mesodermal commitment pathway; TGF-beta signaling pathway; Immune response to tuberculosis; Interferon type I signaling pathways",391.4,362,393.9,470.5,467,382.3,0.8692983785422034,-0.20207664125687141,0.1334163911284909,0.8747908110539929,0.3700722591112486,0.4317134687185854,2635]
["O75928-1","E3 SUMO-protein ligase PIAS2 [OS=Homo sapiens]",4,2,4,1,621,68.2,7.52,10.58,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PIAS2","ENSG00000078043; ENSPTRG00000009998","Ubiquitin mediated proteolysis; JAK-STAT signaling pathway","Activation of anterior HOX genes in hindbrain development during early embryogenesis","Androgen receptor signaling pathway; TGF-beta signaling pathway",74.3,58.8,61.5,65.8,72.4,40.1,1.0914189568143577,0.12620500715611652,0.6458204956531155,0.18988817640184436,0.7502069298678673,0.12481892846912065,6292]
["O75934","Pre-mRNA-splicing factor spf27 [OS=Homo sapiens]",31,7,15,7,225,26.1,5.66,52.21,"RNA metabolism OR transcription;other metabolic processes","cytoskeleton;nucleus;other cell component","","BCAS2","ENSG00000116752","Spliceosome","mRNA Splicing - Major Pathway","",1143.5,1459.1,1171.2,1514.6,1671.1,2946.4,0.6154172306387697,-0.7003632576359526,0.16585533440254766,0.7802705557131797,0.40857318474830495,0.3887301401460486,2967]
["O75935","Dynactin subunit 3 [OS=Homo sapiens]",45,7,19,7,186,21.1,5.47,63.76,"cell cycle OR cell proliferation;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","DCTN3","ENSG00000137100","Amyotrophic lateral sclerosis; Huntington disease; Pathways of neurodegeneration; Salmonella infection","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic","",2655.5,2695.9,2683.7,2600.6,2898.2,2779.9,0.9705750902919541,-0.04308826092725116,0.4051158485449728,0.39242076644121454,0.5839068698511548,0.23365641510511478,5071]
["O75937","DnaJ homolog subfamily C member 8 [OS=Homo sapiens]",12,3,7,3,253,29.8,9.06,20.11,"","non-structural extracellular;cytosol;nucleus","other molecular function","DNAJC8","ENSG00000126698; ENSG00000285317","","mRNA Splicing - Major Pathway","mRNA processing",1090.3,886.3,680.2,947.1,826.4,502,1.1675675675675676,0.2235060416471565,0.5146113573575938,0.2885206332377929,0.6597604649932736,0.18061371235795196,5701]
["O75940","Survival of motor neuron-related-splicing factor 30 [OS=Homo sapiens]",29,4,9,4,238,26.7,7.24,25.68,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","SMNDC1","ENSG00000119953","Spliceosome","mRNA Splicing - Major Pathway","",278.3,323,318.8,424.6,410.3,895.7,0.5316653183866866,-0.9114097353378593,0.16679535854053948,0.7778160387598987,0.4090964011989272,0.3881743409521809,2980]
["O75943-1","cell cycle checkpoint protein RAD17 [OS=Homo sapiens]",5,3,6,3,681,77,7.06,17.38,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","other molecular function","RAD17","ENSG00000152942; ENSG00000276618","","Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA)","miRNA regulation of DNA damage response; Gastric cancer network 2; DNA damage response",461.4,477.8,490.2,485,449.7,308.9,1.1494049533612096,0.2008871715943418,0.31873888973263786,0.4965649444776794,0.539648493179488,0.2678890312499741,4317]
["O75947-1","ATP synthase subunit d, mitochondrial [OS=Homo sapiens]",41,6,30,6,161,18.5,5.3,46.16,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","ATP5PD","ENSG00000167863; ENSGGOG00000013716; ENSPTRG00000009628","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",1942.6,2727.5,1971.9,2101.4,2263.5,1748.1,1.0865368885980697,0.11973715573786257,0.5865473320333892,0.23169693629951665,0.7097805380516624,0.14887591303667555,6040]
["O75955","Flotillin-1 [OS=Homo sapiens]",43,17,73,16,427,47.3,7.49,227.45,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","FLOT1","ENSG00000137312; ENSG00000206379; ENSG00000206480; ENSG00000230143; ENSG00000232280","Insulin signaling pathway","RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Regulation of necroptotic cell death; Synaptic adhesion-like molecules","Angiopoietin-like protein 8 regulatory pathway; Insulin signaling",5795.2,5870.9,5782.5,5138.6,4898,5841.8,1.0988890568319225,0.13604574002893616,0.13963567655297665,0.8550036064222597,0.37813899960196606,0.42234852909480336,2699]
["O75962-1","Triple functional domain protein [OS=Homo sapiens]",4,7,9,6,3097,346.7,6.37,31.13,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;other cell component","enzyme regulator activity;kinase activity;other molecular function","TRIO","ENSG00000038382","","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; G alpha (q) signalling events; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; DCC mediated attractive signaling","Microtubule cytoskeleton regulation; Cell migration and invasion through p75NTR; Neural crest cell migration during development; Neural crest cell migration in cancer",320.6,332.1,312,345.4,310.9,370.8,0.9392464219647553,-0.09042437991974216,0.31937098572717776,0.4957045412687409,0.5403431793240607,0.26733032619968,4320]
["O75962-3","Isoform 3 of Triple functional domain protein [OS=Homo sapiens]",4,2,2,1,596,66.2,7.08,5.3,"","","","TRIO","","","","",215.3,206.6,208.8,190.7,183.2,353.7,0.8668224299065422,-0.2061916097803434,0.5929982495820307,0.22694658858849803,0.7128658233873458,0.14699220597726,6080]
["O75964","ATP synthase subunit g, mitochondrial [OS=Homo sapiens]",30,3,27,3,103,11.4,9.64,83.87,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","ATP5MG","ENSG00000167283","Oxidative phosphorylation; Metabolic pathways; Thermogenesis","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",3643.6,3297.8,3032.4,2797.8,2748.8,1744.5,1.3679417371864326,0.4520067848567022,0.08151553873357367,1.0887595968672965,0.2914858476534687,0.5353825264459986,2044]
["O75976","Carboxypeptidase D [OS=Homo sapiens]",11,11,15,11,1380,152.8,6.05,44.86,"protein metabolism;other metabolic processes","non-structural extracellular;plasma membrane;other membranes","other molecular function","CPD","ENSG00000108582","","Golgi Associated Vesicle Biogenesis; RND3 GTPase cycle; RND1 GTPase cycle","",1259.3,1239.2,1248.7,1315.8,1350.9,1142,0.9838527581589519,-0.023485674616239564,0.7677017848591345,0.11480744968418764,0.8422594334337157,0.07455411615537272,6662]
["O75995","SAM and SH3 domain-containing protein 3 [OS=Homo sapiens]",59,12,44,12,380,41.6,5.27,179.05,"other biological processes","nucleus;other cell component","","SASH3","ENSG00000122122","","","",3214.7,3175.5,2648.6,3914.9,3524.3,4284.5,0.7709852691556419,-0.37522479936330333,0.03500772800475068,1.4558360739541278,0.1944312188348957,0.7112340013480917,1316]
["O76003","glutaredoxin-3 [OS=Homo sapiens]",36,11,63,11,335,37.4,5.39,205.95,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","GLRX3","ENSG00000108010","","Iron uptake and transport","",9111.3,9206.1,9149.5,9436.3,9781.2,9935.1,0.9421766840693455,-0.08593046463671869,0.02002389390430918,1.6984514644832902,0.1467950256234662,0.833288660910973,997]
["O76021","Ribosomal L1 domain-containing protein 1 [OS=Homo sapiens]",44,21,75,21,490,54.9,10.13,204.17,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","RSL1D1","ENSG00000171490","","","Senescence and autophagy in cancer",8107.9,8174.7,8292.7,17856.3,17706.9,16358.4,0.47331553727157866,-1.0791258134687236,4.5071771575249218E-5,4.346095371366914,0.010980985948116551,1.9593586642026037,30]
["O76024","Wolframin [OS=Homo sapiens]",18,13,34,13,890,100.2,8.05,95.23,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","WFS1","ENSG00000109501","Protein processing in endoplasmic reticulum","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; XBP1(S) activates chaperone genes","CAMKK2 pathway",3038.5,2919.4,3092.9,2999.6,3124.4,3463.7,0.9440011681633759,-0.08313945002220917,0.29266173436064086,0.5336340580322629,0.5215958586788403,0.2826658654357747,4101]
["O76031","ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial [OS=Homo sapiens]",46,25,57,25,633,69.2,7.58,171.36,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","CLPX","ENSG00000166855","","","",6418.5,6313.3,6388.4,7453.4,7718.1,7069.6,0.8596787029418508,-0.21813052842424496,0.0055018865688578,2.25948836760445,0.08140341889024628,1.089357354644124,494]
["O76039-1","Cyclin-dependent kinase-like 5 [OS=Homo sapiens]",2,2,4,1,1030,115.5,9.54,11.44,"","","","CDKL5","","","","",235.4,248.1,238.5,219.9,161.5,103.8,1.4880461665292664,0.5734192866540231,0.07938145231885367,1.1002809597461356,0.2882260481860415,0.5402667727508171,2013]
["O76062","Delta(14)-sterol reductase [OS=Homo sapiens]",16,4,8,4,418,46.4,8.87,24.51,"other metabolic processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","other molecular function","TM7SF2","ENSG00000149809","Steroid biosynthesis; Metabolic pathways","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways",663.6,638,657.2,582.3,511.7,578,1.1715311004784688,0.22839525374052078,0.016606412087086728,1.7797241892883984,0.1336743017010098,0.8739520759255105,908]
["O76071","Probable cytosolic iron-sulfur protein assembly protein Ciao1 [OS=Homo sapiens]",43,10,29,10,339,37.8,4.97,123.12,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;other cell component","","CIAO1","ENSG00000144021","","Cytosolic iron-sulfur cluster assembly","",3185.2,3234.4,3387.9,3328.8,3171.5,2221.2,1.1245198647021728,0.1693091466241185,0.3610469923885376,0.44243626843553235,0.5589689615267572,0.2526123069828144,4721]
["O76074","cGMP-specific 3',5'-cyclic phosphodiesterase [OS=Homo sapiens]",18,14,21,14,875,99.9,6.09,54.97,"other metabolic processes;signal transduction","cytosol","other molecular function","PDE5A","ENSG00000138735","Purine metabolism; Metabolic pathways; cGMP-PKG signaling pathway","cGMP effects; RHOBTB1 GTPase cycle","Phosphodiesterases in neuronal function",1255.8,1269.1,1272.4,1482,1500.7,1847,0.7862393109302855,-0.34695959646960967,0.044241900314825854,1.3541662271256436,0.21863695023736454,0.6602764392385632,1479]
["O76075","DNA fragmentation factor subunit beta [OS=Homo sapiens]",12,3,6,3,338,39.1,9,17.17,"cell organization and biogenesis;DNA metabolism;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DFFB","ENSG00000169598","Apoptosis","Apoptosis induced DNA fragmentation","Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis",416.9,448.3,523.7,508.8,422.7,3393.7,0.32111809858503654,-1.6388241155818548,0.3730435831613641,0.4282404260445181,0.5640412803736885,0.24868911023217669,4834]
["O76080","AN1-type zinc finger protein 5 [OS=Homo sapiens]",8,1,1,1,213,23.1,8.51,4.43,"developmental processes;signal transduction;other biological processes","other cell component","nucleic acid binding activity;other molecular function","ZFAND5","ENSG00000107372","","","",53.1,61.5,52.8,108.3,110.2,108.1,0.5125535823637476,-0.9642252630113515,5.4556384201604475E-5,4.263154420853911,0.01208341248877355,1.917810398847825,33]
["O76094","Signal recognition particle subunit SRP72 [OS=Homo sapiens]",38,21,73,21,671,74.6,9.26,247.63,"transport","cytosol;ER/Golgi;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","SRP72","ENSG00000174780","Protein export","SRP-dependent cotranslational protein targeting to membrane","",9924.4,9980.8,10296.6,10519.1,9201.6,8103.1,1.0854663992696898,0.11831506786253235,0.3255339803795466,0.48740367154714437,0.5439707047540252,0.2644244883647897,4374]
["O76095-1","Protein JTB [OS=Homo sapiens]",9,1,1,1,146,16.3,8.28,3.64,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion;other cell component","other molecular function","JTB","ENSG00000143543; ENSGGOG00000005608; ENSPPAG00000028370; ENSPTRG00000001369","","","",57.9,64.2,70,71.7,76.3,67.8,0.8901760889712697,-0.16783734582248985,0.1380463678222798,0.8599750157215175,0.37592433025821276,0.42489956533449896,2684]
["O77932","Decapping and exoribonuclease protein [OS=Homo sapiens]",5,2,3,2,396,44.9,7.69,7.27,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus","nucleic acid binding activity;other molecular function","DXO","ENSG00000204348; ENSG00000206346; ENSG00000224313; ENSG00000225682; ENSG00000234798; ENSG00000236765","","","",341,360.3,367.7,384.9,367.5,363.2,0.9582287558264612,-0.06155798642045905,0.20819134269604878,0.6815373338913142,0.4535530622251626,0.3433718965123521,3355]
["O94760-1","N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 [OS=Homo sapiens]",33,8,25,7,285,31.1,5.81,85.27,"other metabolic processes;signal transduction;other biological processes","cytosol","other molecular function","DDAH1","ENSG00000153904; ENSMFAG00000037521; ENSMMUG00000014573; ENSMNEG00000044101; ENSRBIG00000034663; ENSRROG00000009892","","eNOS activation","Mesodermal commitment pathway; Nitric oxide metabolism in cystic fibrosis",3052.2,3029.7,3155.1,2876.7,2912.8,2412.7,1.1261612738045887,0.17141344576400383,0.10564640447965593,0.9761452789355356,0.3352885672348264,0.47458125501579373,2303]
["O94761","ATP-dependent DNA helicase Q4 [OS=Homo sapiens]",7,6,8,6,1208,133,8.09,22.05,"","","","","","","","",453.7,453.5,513.1,461.1,447.4,518,0.9956536978618998,-0.00628405465481879,0.947217439273913,0.023550314727249468,0.9665241188961371,0.01478730400189833,7163]
["O94762-1","ATP-dependent DNA helicase Q5 [OS=Homo sapiens]",6,5,7,5,991,108.8,8.56,19.38,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RECQL5","ENSG00000108469","","","",605.5,628,638.2,760.7,768.6,1122.2,0.7059023194418254,-0.5024595332134,0.09544309147341563,1.0202555019854402,0.31810011654318054,0.4974361717789902,2193]
["O94763-1","Unconventional prefoldin RPB5 interactor 1 [OS=Homo sapiens]",10,5,6,5,535,59.8,5.05,19.81,"other biological processes","cytosol;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","URI1","ENSG00000105176","","","",676.7,718.9,651.9,787.8,830.6,502.8,0.9652555157458041,-0.051017201725012735,0.8260438663411475,0.08299688923645596,0.881652251619078,0.054702679021579846,6848]
["O94766","Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 [OS=Homo sapiens]",18,4,7,4,335,37.1,8.27,23.83,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","enzyme regulator activity;other molecular function","B3GAT3","ENSG00000149541","Glycosaminoglycan biosynthesis; Glycosaminoglycan biosynthesis; Metabolic pathways","A tetrasaccharide linker sequence is required for GAG synthesis; Defective B3GAT3 causes JDSSDHD","Proteoglycan biosynthesis",563.2,528.4,555.9,565.6,560.6,748,0.8790417244691068,-0.1859964491364059,0.2935742185163068,0.5322820865207304,0.5215687805385723,0.2826884119954627,4114]
["O94768","Serine/threonine-protein kinase 17B [OS=Homo sapiens]",16,5,12,5,372,42.3,5.25,31.11,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus","kinase activity;other molecular function","STK17B","ENSG00000081320","","","",785.3,789.6,838.1,922.7,877.1,2321,0.5855659095321296,-0.7720965296201769,0.29617216986811423,0.5284557528389493,0.5238921562357325,0.28075810380255933,4132]
["O94776","Metastasis-associated protein MTA2 [OS=Homo sapiens]",41,28,99,27,668,75,9.66,247.68,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MTA2","ENSG00000149480","","Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation","Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome",10368,10089.3,10528.2,11132,10996.7,10456,0.9509217516196251,-0.0726014637855616,0.09338518928501308,1.0297219965946736,0.31483041904250947,0.5019233125770499,2168]
["O94788-1","retinal dehydrogenase 2 [OS=Homo sapiens]",3,2,5,1,518,56.7,6.05,11.85,"cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;other cell component","other molecular function","ALDH1A2","ENSG00000128918","Retinol metabolism; Metabolic pathways","RA biosynthesis pathway","Ethanol effects on histone modifications; Tryptophan metabolism; 22q11.2 copy number variation syndrome; Vitamin A and carotenoid metabolism",795.6,747.3,794.6,778.3,781,1723.3,0.7120879790410041,-0.4898725965540123,0.37379336222178094,0.42736841503864276,0.5641246509351636,0.24862492220120908,4843]
["O94804","Serine/threonine-protein kinase 10 [OS=Homo sapiens]",35,32,105,30,968,112.1,6.95,298.67,"cell adhesion;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol","kinase activity;other molecular function","STK10","ENSG00000072786","Progesterone-mediated oocyte maturation","RHOA GTPase cycle; RHOB GTPase cycle; Neutrophil degranulation; RHOC GTPase cycle","",10379.3,10229.8,9850.4,11283,10993.2,8945.6,0.9755843673330812,-0.03566145416996654,0.7525103067130241,0.12348754740463182,0.8304541494436801,0.08068434056754699,6623]
["O94806","Serine/threonine-protein kinase D3 [OS=Homo sapiens]",18,12,29,9,890,100.4,6.87,95.06,"protein metabolism;other metabolic processes;signal transduction","other membranes;cytosol;nucleus","kinase activity;other molecular function","PRKD3","ENSG00000115825","Rap1 signaling pathway; Aldosterone synthesis and secretion; Chemical carcinogenesis","Sphingolipid de novo biosynthesis","G protein signaling pathways; Hippo signaling regulation pathways",2352.5,2460.9,2467.1,2691.5,2633.2,3264.2,{"$f":"AVERAGE(S706:U706)/AVERAGE(V706:X706)","v":0.8476638451955432},{"$f":"LOG(Y706,2)","v":-0.2384358407330571},{"$f":"TTEST(V706:X706,S706:U706,2,2)","v":0.10017711982587653},0.9992314587885485,{"$f":"AA706*7309/AE706","v":0.32614457407898956},0.48658984224391744,2245]
["O94811","Tubulin polymerization-promoting protein [OS=Homo sapiens]",24,4,5,4,219,23.7,9.44,10.69,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","TPPP","ENSG00000171368","","","Microtubule cytoskeleton regulation; Glial cell differentiation; Sudden infant death syndrome (SIDS) susceptibility pathways",463.2,485.2,449.4,435.5,410.6,309.8,1.2092741586642444,0.2741413599768276,0.11284122727156366,{"$f":"-LOG10(AA707)","v":0.947532199064266},0.3435054269587084,{"$f":"-LOG10(AC707)","v":0.4640663972373203},2401]
["O94813","Slit homolog 2 protein [OS=Homo sapiens]",0,1,1,1,1529,169.8,7.06,1.9,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;other membranes;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","SLIT2","ENSG00000145147","Axon guidance","Regulation of expression of SLITs and ROBOs; Netrin-1 signaling; Inactivation of CDC42 and RAC1; Activation of RAC1; Regulation of commissural axon pathfinding by SLIT and ROBO; Role of ABL in ROBO-SLIT signaling; SLIT2:ROBO1 increases RHOA activity","Spinal cord injury; Robo4 and VEGF signaling pathways crosstalk; Genes controlling nephrogenesis; GDNF/RET signaling axis; Development of ureteric collection system",178.8,206.9,168.1,172.1,165.3,13.5,1.5782274152180111,0.6583051059647641,0.27134707855827356,0.5664748498643134,0.5076211408196625,0.29446029920512495,3907]
["O94822","E3 ubiquitin-protein ligase listerin [OS=Homo sapiens]",20,28,49,28,1766,200.4,6.25,119.14,"protein metabolism;other metabolic processes","cytosol;other cell component","translation activity;other molecular function","LTN1","ENSG00000198862","","Antigen processing: Ubiquitination & Proteasome degradation","",4279,4375.2,4246.9,4862.3,4536.2,4651.4,0.9182342934825158,-0.12306578120642356,0.020492057639129042,1.688414431230184,0.14785434282763493,0.8301659147064916,1013]
["O94826","Mitochondrial import receptor subunit TOM70 [OS=Homo sapiens]",57,28,155,28,608,67.4,7.12,436.56,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","TOMM70","ENSG00000154174","","Mitochondrial protein import; Ub-specific processing proteases; DDX58/IFIH1-mediated induction of interferon-alpha/beta; PINK1-PRKN Mediated Mitophagy","Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation",21165.2,20662.1,21307.4,18930.9,19424.1,14765.8,1.188511844701134,0.2491562812411686,0.08865010010874588,1.0523207696327037,0.305777999855981,0.5145937644595254,2119]
["O94829","Importin-13 [OS=Homo sapiens]",13,11,22,11,963,108.1,5.3,61.34,"transport","nucleus;other cell component","other molecular function","IPO13","ENSG00000117408","Nucleocytoplasmic transport","","",1605.2,1524.9,1641.2,1528.8,1463.9,2174.7,0.9233463637419207,-0.1150561647645237,0.5958668275774825,0.22485079145230202,0.7150206276085732,0.14568142906975037,6091]
["O94830","Phospholipase DDHD2 [OS=Homo sapiens]",5,3,3,3,711,81,5.39,2.46,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","DDHD2","ENSG00000085788","","Synthesis of PA","",76.7,76.1,81.1,85.4,77.2,94.5,0.9097627382341501,-0.1364377484812285,0.21396084643905178,0.6696656926844691,0.4598176496980387,0.3374143627332182,3401]
["O94832","Unconventional myosin-Id [OS=Homo sapiens]",39,37,92,37,1006,116.1,9.39,237.91,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","MYO1D","ENSG00000176658","Pathogenic Escherichia coli infection","","",11077.5,11337.8,10828.4,9151.4,8683.2,9277.3,1.226166369749077,0.2941547412863264,9.3128743660401991E-4,3.0309162557912948,0.03802670320747922,1.4199113248872148,179]
["O94842","TOX high mobility group box family member 4 [OS=Homo sapiens]",11,5,6,4,621,66.2,5.06,17.83,"other biological processes","nucleus;other cell component","nucleic acid binding activity","TOX4","ENSG00000092203","","","",519.6,513.4,511.9,648.7,697,598.9,0.7944564434845214,-0.3319599697017783,0.009389329551529605,2.0273654175812235,0.10136869969295405,0.9940961243823947,677]
["O94854","Uncharacterized protein KIAA0754 [OS=Homo sapiens]",2,1,1,1,1291,135.1,4.21,2.88,"","","","KIAA0754","","","","",14,15.8,11.8,17.9,16.3,5.2,1.0558375634517765,0.07838789868471567,0.8685623137317335,0.06119901827729087,0.9147437969834641,0.0387005268481728,6940]
["O94855","Protein transport protein Sec24D [OS=Homo sapiens]",22,19,48,18,1032,112.9,7.25,143.74,"cell organization and biogenesis;transport;developmental processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","SEC24D","ENSG00000150961","Protein processing in endoplasmic reticulum; Pathogenic Escherichia coli infection","MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Sterol regulatory element-binding proteins (SREBP) signaling",3638.1,3706,3665.3,4096.1,3868.7,3572,0.9542854171000626,-0.06750726864545145,0.31461562257110093,0.5022197158259984,0.5366454108219781,0.2703125802012425,4285]
["O94864-1","STAGA complex 65 subunit gamma [OS=Homo sapiens]",17,3,4,3,414,46.2,5.12,5.49,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","SUPT7L","ENSG00000119760; ENSPTRG00000011777","","HATs acetylate histones","",381.7,374.4,352.7,410.9,490.8,375.1,0.8684210526315788,-0.20353339408513238,0.18773836617427803,0.7264469659768371,0.43204651082109513,0.36446949784792276,3176]
["O94868","F-BAR and double SH3 domains protein 2 [OS=Homo sapiens]",13,8,12,8,740,84.2,5.77,33.34,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","FCHSD2","ENSG00000137478","","","",779.4,816.5,877.8,1063.9,1058.2,1040.8,0.7820987068829237,-0.3545773966336594,1.4701233399275727E-3,2.832646227426752,0.043857679557267874,1.357954349907312,245]
["O94874-1","E3 UFM1-protein ligase 1 [OS=Homo sapiens]",51,38,145,15,794,89.5,6.79,367.15,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","UFL1","ENSG00000014123","","Antigen processing: Ubiquitination & Proteasome degradation","",14703.4,15034.9,14836.4,13778.2,13336.4,12167.2,1.1347417888182312,0.18236404873046302,0.022768686482984836,1.6426620229485758,0.15567477034998706,0.8077817662733808,1069]
["O94874-3","Isoform 3 of E3 UFM1-protein ligase 1 [OS=Homo sapiens]",52,23,71,1,509,57.5,6.3,196.23,"","","","UFL1","","","","",30.5,56.6,59.2,51.3,34.9,11.4,1.498975409836066,0.5839767165756009,0.3333406365432437,0.4771117395926058,0.547010936797164,0.2620039904066522,4454]
["O94876","Transmembrane and coiled-coil domains protein 1 [OS=Homo sapiens]",11,5,7,5,653,72,6.55,21.85,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","TMCC1","ENSG00000172765","","","",182.3,167.3,186.1,177.2,164.3,316,0.8147528517110267,-0.29556559834738744,0.45304850060225427,0.343855302586681,0.6168650318371602,0.20980984786364373,5368]
["O94880","PHD finger protein 14 [OS=Homo sapiens]",9,7,14,7,888,100,5.33,29.98,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","PHF14","ENSG00000106443","","","",1494.7,1536.7,1558.1,1787.5,1894.9,2230.1,0.7762367864693446,-0.3654312896958208,0.030593542857685514,1.5143702270215673,0.1815001661906034,0.7411229729660012,1232]
["O94886","CSC1-like protein 1 [OS=Homo sapiens]",18,10,23,10,807,92.1,7.27,71.54,"transport","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","transporter activity;nucleic acid binding activity","TMEM63A","ENSG00000196187","","Neutrophil degranulation","",2067.9,2007.6,2163.5,1983.4,1961.1,2328.4,0.9945958009851902,-0.007817754547643243,0.9335132082608224,0.02987953284697649,0.957889658736256,0.01868451530757274,7123]
["O94887-1","FERM, RhoGEF and pleckstrin domain-containing protein 2 [OS=Homo sapiens]",11,7,7,7,1054,119.8,8.79,30.06,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity","FARP2","ENSG00000006607","Rap1 signaling pathway; Adherens junction","RAC1 GTPase cycle; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion","",529.6,554.1,542.2,500.7,469,1188.4,0.7533941893332097,-0.4085231885631535,0.4919807160588609,0.30805191973946416,0.6422373734013599,0.192304425350475,5599]
["O94888","UBX domain-containing protein 7 [OS=Homo sapiens]",42,16,38,15,489,54.8,5.16,97.06,"","other membranes;cytosol;ER/Golgi;nucleus","other molecular function","UBXN7","ENSG00000163960","","Neddylation","3q29 copy number variation syndrome",3614.4,3616.3,3692.7,4127.1,4283.4,6674,0.7241473035234844,-0.46564489972399864,0.16782950708448005,0.7751316809484299,0.4095712411620917,0.3876705457897871,2995]
["O94901-9","Isoform 9 of SUN domain-containing protein 1 [OS=Homo sapiens]",21,14,35,13,916,101.9,7.31,101.23,"","","","SUN1","","","","",1871,1907.7,2015,1782,1924.9,2456.9,0.939955871378046,-0.08933506749971343,0.5881689845842766,0.23049788050736286,0.7105664641861946,0.1483952932758588,6050]
["O94903","Pyridoxal phosphate homeostasis protein [OS=Homo sapiens]",43,11,42,11,275,30.3,7.5,111.97,"","cytosol;other cell component","other molecular function","PLPBP","ENSG00000147471","","","",4586,4511.7,4585.9,4418.8,4563.5,4315.3,1.0290277944892312,0.04128195058001331,0.1662051413315393,0.7793555460309591,0.4090213393913201,0.3882540334641985,2970]
["O94905-1","Erlin-2 [OS=Homo sapiens]",32,10,32,7,339,37.8,5.62,86.04,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","ERLIN2","ENSG00000147475; ENSGGOG00000012855; ENSPPAG00000034728; ENSPTRG00000020158","","ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Signaling by FGFR1 in disease; Signaling by plasma membrane FGFR1 fusions","",3011.3,3048.8,3170.9,2778.5,2740.5,2371.1,1.1699471489588218,0.22644335916150474,0.03211494530649892,1.4932928132764083,0.18599693759524613,0.7304942063005508,1262]
["O94906-1","Pre-mRNA-processing factor 6 [OS=Homo sapiens]",54,49,151,49,941,106.9,8.25,459.51,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PRPF6","ENSG00000101161; ENSGGOG00000016876; ENSPPAG00000008686; ENSPTRG00000013765","Spliceosome","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","mRNA processing; mRNA Processing",19195.7,18817.6,19102.5,18138.1,17969.8,17196.7,1.0714985198275575,0.09962985707100053,0.015097046686989048,1.8211080019113919,0.12771332666111454,0.893763782506312,864]
["O94913","Pre-mRNA cleavage complex 2 protein Pcf11 [OS=Homo sapiens]",9,13,22,13,1555,172.9,8.48,58.17,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","PCF11","ENSG00000165494","mRNA surveillance pathway","RNA polymerase II transcribes snRNA genes; mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs","",2673.6,2614.3,2621.2,2663.5,2816.9,2522.7,0.9882545513613474,-0.017045400560839166,0.7369237698580597,0.13257743485772114,0.8178220215445731,0.08734119934963719,6586]
["O94915-1","protein furry homolog-like [OS=Homo sapiens]",9,26,41,20,3013,339.4,5.58,118.14,"cell organization and biogenesis;developmental processes;other biological processes","other cell component","","FRYL","ENSG00000075539","","","",3875.1,3805.6,3833.7,3780.5,3708.1,3843.5,1.0160870447666364,0.023023998245944973,0.23956754620782253,0.6205720154041582,0.4826348388183503,0.3163813319082429,3628]
["O94915-2","Isoform 2 of Protein furry homolog-like [OS=Homo sapiens]",19,7,12,1,403,45.6,4.5,39.26,"","","","FRYL","","","","",287.2,294.4,306.7,300.7,286.7,341.2,0.9566013353435279,-0.06401028966795164,0.4809164286184994,0.3179303867097423,0.6348235825849038,0.19734694833770272,5537]
["O94916","nuclear factor of activated T-cells 5 [OS=Homo sapiens]",2,2,2,2,1531,165.7,5.24,2.25,"RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NFAT5","ENSG00000102908","","","Cancer immunotherapy by PD-1 blockade",78.9,86.9,89.7,100.1,112.7,130.2,0.7448979591836735,-0.4248852852351909,0.035066527320548165,1.455107240682472,0.1944622520378502,0.7111646890564901,1318]
["O94919","endonuclease domain-containing 1 protein [OS=Homo sapiens]",25,8,25,8,500,55,5.71,78.53,"other metabolic processes","non-structural extracellular;cytosol","nucleic acid binding activity;other molecular function","ENDOD1","ENSG00000149218","","Platelet degranulation","",1493.6,1473.4,1595.2,1378.2,1398.8,1541.6,1.0564071689899504,0.07916599706743128,0.2715407355145527,0.5661650099714981,0.5074638803057698,0.29459486403965585,3911]
["O94921-1","Cyclin-dependent kinase 14 [OS=Homo sapiens]",14,6,12,4,469,53,8.92,26.99,"cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","CDK14","ENSCATG00000032271; ENSCSAG00000012501; ENSG00000058091; ENSGGOG00000003585; ENSMLEG00000038830; ENSMNEG00000032203; ENSPANG00000022338","Transcriptional misregulation in cancer","","",609,604.9,623.4,673,615.8,607.9,0.9686824484631203,-0.04590429313855609,0.40448146685488856,0.39310137275887436,0.5835679118125504,0.23390859632943056,5066]
["O94923","D-glucuronyl C5-epimerase [OS=Homo sapiens]",5,2,2,2,617,70.1,8.97,5.72,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","GLCE","ENSG00000138604","Glycosaminoglycan biosynthesis; Metabolic pathways","HS-GAG biosynthesis","",150.3,158.5,174.9,154.5,191.8,246.1,0.8165091154625254,-0.29245910284298504,0.2589154441713844,0.5868420433528383,0.4986595471537941,0.3021958617003644,3795]
["O94925-1","Glutaminase kidney isoform, mitochondrial [OS=Homo sapiens]",49,24,114,5,669,73.4,7.77,364.69,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;mitochondrion;other cell component","other molecular function","GLS","ENSG00000115419; ENSGGOG00000007590; ENSPTRG00000012747","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; D-Amino acid metabolism; Metabolic pathways; Glutamatergic synapse; GABAergic synapse; Proximal tubule bicarbonate reclamation; MicroRNAs in cancer; Central carbon metabolism in cancer","Glutamate Neurotransmitter Release Cycle; TP53 Regulates Metabolic Genes; Glutamate and glutamine metabolism","Amino acid metabolism; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling",12809.7,13063.4,13234,12737.1,12722.9,9590.2,1.1157454165739424,0.15800788008326985,0.2687197281472206,0.5707004485241686,0.5051626782479515,0.29656874289443264,3888]
["O94925-3","Isoform 3 of Glutaminase kidney isoform, mitochondrial [OS=Homo sapiens]",50,22,119,3,598,65.4,7.88,372.88,"","","","GLS","","","","",2412.3,2348.9,2468.9,2522.8,2554.2,1950,1.0289028034723209,0.041106702764899875,0.7513100522279754,0.12418080043491928,0.8295053129507964,0.08118082799064624,6620]
["O94927","HAUS augmin-like complex subunit 5 [OS=Homo sapiens]",6,3,5,3,633,71.6,8.51,15.7,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","","HAUS5","ENSG00000249115","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",194,227.6,235.5,232.9,213,223.9,0.9810391161540759,-0.02761743392048095,0.7768671608989252,0.10965323630939383,0.8490015070290438,0.0710915388563808,6688]
["O94941-1","RING finger protein 37 [OS=Homo sapiens]",3,1,4,1,541,58.9,7.56,12.59,"protein metabolism;other metabolic processes","nucleus;other cell component","other molecular function","UBOX5","ENSG00000185019","Ubiquitin mediated proteolysis","Antigen processing: Ubiquitination & Proteasome degradation","",32.8,28.8,33.5,40.5,35.9,63.2,0.6812320916905443,-0.5537816953490889,0.15832104398006377,0.8004613550239564,0.3976524090894454,0.4004963821258908,2910]
["O94953","lysine-specific demethylase 4B [OS=Homo sapiens]",8,6,13,6,1096,121.8,7.09,46.78,"cell organization and biogenesis;protein metabolism;other metabolic processes","nucleus","other molecular function","KDM4B","ENSG00000127663","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Estrogen-dependent gene expression; HDMs demethylate histones","",405.3,401,401.7,454.6,461.1,446.6,0.886735667620935,-0.17342398793304922,3.0618833725460292E-4,3.5140113556443975,0.021727481135863036,1.6629906184655965,103]
["O94964-2","Isoform 2 of Protein SOGA1 [OS=Homo sapiens]",3,5,5,3,1661,183.7,6.52,15.95,"","","","SOGA1","","","","",217.7,223,230.5,290.8,299.1,1118.2,0.39295123236344476,-1.3475778185182097,0.27637848876082843,0.5584957622241262,0.5111463497856515,0.2914547362557438,3952]
["O94966-5","Isoform 5 of Ubiquitin carboxyl-terminal hydrolase 19 [OS=Homo sapiens]",14,12,20,12,1419,155.9,6.38,58.78,"","","","USP19","","","","",820.2,854.8,824,926.5,885.7,838.2,0.9428765469363115,-0.08485920710694835,0.14329081745996786,0.8437816397090248,0.381395697310599,0.41862421072578815,2746]
["O94973","AP-2 complex subunit alpha-2 [OS=Homo sapiens]",37,28,67,18,939,103.9,6.96,194.09,"transport","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","AP2A2","ENSG00000183020","Endocytosis; Synaptic vesicle cycle; Endocrine and other factor-regulated calcium reabsorption; Huntington disease","Neutrophil degranulation; MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; Recycling pathway of L1; Potential therapeutics for SARS; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation","Synaptic vesicle pathway; GABA receptor signaling; mBDNF and proBDNF regulation of GABA neurotransmission",3395.2,3305,3394.6,3156.2,3140.9,3008.8,1.0847741755230549,0.1173947387414918,0.00908706250463255,2.0415764846773543,0.10032830792501404,0.9985765122330811,662]
["O94979","Protein transport protein Sec31A [OS=Homo sapiens]",41,39,144,39,1220,132.9,6.89,421.07,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","SEC31A","ENSG00000138674","Protein processing in endoplasmic reticulum","Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Signaling by ALK fusions and activated point mutants; MHC class II antigen presentation; COPII-mediated vesicle transport; XBP1(S) activates chaperone genes","Sterol regulatory element-binding proteins (SREBP) signaling",17595.2,17789,17997.8,17881,16696.8,16012.8,1.055176258040031,0.07748400875322026,0.17071257978985854,0.7677344745969364,0.4127483445861978,0.38431465989078056,3023]
["O94986-1","Isoform 1 of Centrosomal protein of 152 kDa [OS=Homo sapiens]",6,6,6,6,1275,147.3,5.43,14.01,"","","","CEP152","","","","",365.8,405.5,314.7,434.1,455.4,1351.4,0.48462671248159217,-1.0450541669808873,0.2733344130957861,0.563305686723938,0.5087347148757577,0.2935086261103833,3927]
["O94992","Protein HEXIM1 [OS=Homo sapiens]",4,2,2,2,359,40.6,4.89,2.06,"stress response;developmental processes;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","HEXIM1","ENSG00000186834","","","Initiation of transcription and translation elongation at the HIV-1 LTR",239.7,174.5,146.8,271.4,191,152,0.9130859375000001,-0.1311774452250008,0.7105303673806682,0.14841735601375194,0.796513259997746,0.09880698986169918,6520]
["O95067","G2/mitotic-specific cyclin-B2 [OS=Homo sapiens]",12,3,3,3,398,45.3,8.9,12.41,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity","CCNB2","ENSG00000157456","FoxO signaling pathway; Cell cycle; Oocyte meiosis; p53 signaling pathway; Cellular senescence; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection; Human immunodeficiency virus 1 infection","Resolution of Sister Chromatid Cohesion; Initiation of Nuclear Envelope (NE) Reformation; The role of GTSE1 in G2/M progression after G2 checkpoint; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; Cyclin A/B1/B2 associated events during G2/M transition; Golgi Cisternae Pericentriolar Stack Reorganization; Polo-like kinase mediated events; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint","miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; TGF-beta signaling pathway; IL-18 signaling pathway; DNA damage response",421.8,377.2,393.8,364.3,327.7,299.4,1.2031470647569094,0.2668129988131156,0.042493292052521746,1.371679621820322,0.214788016329102,0.667989952894861,1446]
["O95070","protein YIF1A [OS=Homo sapiens]",2,1,3,1,293,32,8.95,3.54,"transport","other membranes;ER/Golgi;other cell component","","YIF1A","ENSG00000174851","","XBP1(S) activates chaperone genes","",224.4,225.5,234.1,215.1,237.3,832.4,0.5323785803237858,-0.9094755677440542,0.3780076007318656,0.42249946756298445,0.5665075976520824,0.24679426127057782,4877]
["O95071","E3 ubiquitin-protein ligase UBR5 [OS=Homo sapiens]",17,37,75,37,2799,309.2,5.85,229.82,"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","UBR5","ENSG00000104517","Ubiquitin mediated proteolysis","","Mesodermal commitment pathway",7289,7125.7,7269.5,7174.1,7110.2,7044.9,1.0166438497458883,0.023814363369600685,0.13621955080289272,0.865760556178991,0.3735942577179523,0.4275998076576091,2665]
["O95081","Arf-GAP domain and FG repeat-containing protein 2 [OS=Homo sapiens]",2,1,1,1,481,48.9,9.11,3.14,"","","enzyme regulator activity;other molecular function","AGFG2","ENSG00000106351","","","",72.9,84.7,64,55.8,67.2,77.5,1.1052369077306734,0.1443556447069058,0.46287446243649816,0.3345367793140875,0.6225891508922277,0.20579845151198647,5434]
["O95104","Splicing factor, arginine/serine-rich 15 [OS=Homo sapiens]",16,15,30,14,1147,125.8,9.55,88.37,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","SCAF4","ENSG00000156304","","","",2219.7,2280.6,2234.9,2597.2,2561.5,2973,0.8282646924997231,-0.27183620453943796,0.024829110196616207,1.6050388440227157,0.1640831522848715,0.7849360091074222,1106]
["O95136","Sphingosine 1-phosphate receptor 2 [OS=Homo sapiens]",3,1,1,1,353,38.8,8.97,2.94,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","S1PR2","ENSG00000267534","Sphingolipid signaling pathway; Neuroactive ligand-receptor interaction","G alpha (i) signalling events; Lysosphingolipid and LPA receptors","Small ligand GPCRs; S1P receptor signal transduction; Sphingolipid metabolism in senescence",37.6,38.9,37.8,42.9,34.1,57.1,0.8523489932885907,-0.23048383368999556,0.38115207362255743,0.4189017131486142,0.568191006752452,0.24550564451081947,4903]
["O95139","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [OS=Homo sapiens]",31,4,13,4,128,15.5,9.63,34.02,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB6","ENSG00000165264","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",943.9,1277,969.7,1164.8,1474.7,1949.2,0.6953167563798027,-0.5242577375524503,0.13802461061637458,0.8600434693817991,0.3760051729389049,0.4248061801697651,2683]
["O95140","Mitofusin-2 [OS=Homo sapiens]",18,12,18,12,757,86.3,6.98,52.88,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion","other molecular function","MFN2","ENSG00000116688","Mitophagy; NOD-like receptor signaling pathway; Parkinson disease; Pathways of neurodegeneration","Factors involved in megakaryocyte development and platelet production; PINK1-PRKN Mediated Mitophagy; RHOT2 GTPase cycle","Intracellular trafficking proteins involved in CMT neuropathy",1171.3,1206,1183.8,1250.4,1203.6,3013.7,0.6512976205717214,-0.6186111388958578,0.3462198395693897,0.46064804920286817,0.5525154601337705,0.25765556532276446,4580]
["O95149","Snurportin-1 [OS=Homo sapiens]",5,2,5,2,360,41.1,6.64,11.37,"transport","cytosol;nucleus","nucleic acid binding activity;other molecular function","SNUPN","ENSG00000169371","Nucleocytoplasmic transport","snRNP Assembly","",547.7,598.7,586.3,648.7,679.4,706.4,0.8516588842467439,-0.2316523927793095,0.01134416812317163,1.9452273457695535,0.11189544509077118,0.9511875918649088,741]
["O95155","Ubiquitin conjugation factor E4 B [OS=Homo sapiens]",21,21,35,20,1302,146.1,6.55,90.04,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","other molecular function","UBE4B","ENSG00000130939","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum","","",2529.4,2622.9,2671.8,2872.2,2844,2285.2,0.9778413777588922,-0.032327640017360784,0.7776553830896709,0.10921281737997364,0.8497358641056069,0.070716051448634,6689]
["O95159","Zinc finger protein-like 1 [OS=Homo sapiens]",12,3,9,3,310,34.1,8.07,41.08,"transport;other biological processes","other membranes;ER/Golgi;nucleus","nucleic acid binding activity;other molecular function","ZFPL1","ENSG00000162300","","","",781.8,799.9,952,1088.1,1111.3,1463.7,0.6916819087657996,-0.5318193722733368,0.047280564667366326,1.3253173453574079,0.2242528534417784,0.6492620221918541,1541]
["O95163","Elongator complex protein 1 [OS=Homo sapiens]",21,22,60,22,1332,150.2,5.94,211.47,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","ELP1","ENSG00000070061","","HATs acetylate histones","",5594.7,5736,5792.8,5656.9,5616.5,4565.4,1.081110942748188,0.1125145788911702,0.3024600488174145,0.51933198208255,0.5276087104550078,0.27768804316487244,4190]
["O95166","Gamma-aminobutyric acid receptor-associated protein [OS=Homo sapiens]",6,1,1,1,117,13.9,8.79,2.91,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","GABARAP","ENSG00000170296","FoxO signaling pathway; Autophagy; Mitophagy; Autophagy; NOD-like receptor signaling pathway; GABAergic synapse","Macroautophagy; TBC/RABGAPs","Senescence and autophagy in cancer",134.5,194.6,127.9,233.3,245.6,81.6,0.8153434433541481,-0.29452020774735704,0.5766717732685727,0.2390713057656482,0.704242939151211,0.15227749862410472,5985]
["O95167","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [OS=Homo sapiens]",49,3,11,3,84,9.3,8.46,20.56,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity","NDUFA3","ENSG00000170906; ENSG00000273642; ENSG00000274359; ENSG00000275605; ENSG00000275724; ENSG00000276061; ENSG00000276220; ENSG00000276766; ENSG00000277722; ENSG00000278365","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",1143.2,1140.7,991.8,1248.2,1493.8,758,0.9359142857142856,-0.09555168605875482,0.7532068014935939,0.12308576693763545,0.8310972995345226,0.08034812883048621,6624]
["O95168-1","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [OS=Homo sapiens]",14,1,1,1,129,15.2,9.85,5.37,"cell organization and biogenesis;other metabolic processes;stress response;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB4","ENSG00000065518; ENSGGOG00000013923; ENSPPAG00000027750; ENSPTRG00000015270","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",52.8,67.8,58.8,54.2,68,286,0.43949044585987257,-1.1860962921134581,0.3678479458394315,0.43433166483037366,0.5615289549165423,0.25062784468077376,4788]
["O95169","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [OS=Homo sapiens]",28,4,7,4,186,21.8,6.8,13.42,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;ER/Golgi","transporter activity","NDUFB8","ENSG00000166136","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Mitochondrial protein import; Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",707,728.9,829.5,726.9,834.8,1961.3,0.6430315072381494,-0.6370386664747268,0.350032757879637,0.45589131021930573,0.5547245072294594,0.25592264695799416,4612]
["O95182","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [OS=Homo sapiens]",5,1,1,1,113,12.5,10.18,0,"protein metabolism;other metabolic processes;transport","other membranes;mitochondrion;translational apparatus","transporter activity;other molecular function","NDUFA7","ENSG00000267855","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",103.7,96,94.5,103.3,107.3,181.8,0.7497451580020388,-0.4155277949644085,0.27151513290442614,0.5662059599840296,0.5075458072630309,0.29452475549592344,3910]
["O95183","vesicle-associated membrane protein 5 [OS=Homo sapiens]",16,2,2,1,116,12.8,7.85,5.66,"transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","VAMP5","ENSG00000168899","SNARE interactions in vesicular transport","","",45.8,52.9,58.6,38.7,38,81.8,0.9924290220820188,-0.010964169611083152,0.9799366883973035,0.008801982233930899,0.9875027237689082,0.005461697811704242,7253]
["O95197","Reticulon-3 [OS=Homo sapiens]",3,4,20,4,1032,112.5,4.96,41.5,"cell organization and biogenesis;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","","RTN3","ENSG00000133318","Alzheimer disease","Synaptic adhesion-like molecules","Alzheimer's disease and miRNA effects; Alzheimer's disease",3731.9,3848.4,3834.6,3711.6,3401.7,5506,0.9045588899542764,-0.1447136644794002,0.5741464904904161,0.2409772854856656,0.702450066788492,0.15338454186980213,5974]
["O95202-1","mitochondrial proton/calcium exchanger protein [OS=Homo sapiens]",48,34,143,34,739,83.3,6.7,456.4,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity;translation activity;other molecular function","LETM1","ENSG00000168924","","RHOG GTPase cycle; Mitochondrial calcium ion transport","",14590.5,14112.2,14817.2,12055.3,13086.7,8128.8,1.3080509034949563,0.3874186851714506,0.08854020751920669,1.0528594644631033,0.3056874713074547,0.5147223605985424,2117]
["O95208-1","epsin-2 [OS=Homo sapiens]",7,5,7,4,641,68.4,7.52,20.07,"transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","EPN2","ENSG00000072134","Endocytosis","Cargo recognition for clathrin-mediated endocytosis","",526.8,517.8,531.4,578.9,661.9,950,0.7193719189337228,-0.4751902506847988,0.142660150520086,0.8456973220929307,0.3811049123360045,0.4189554532570364,2736]
["O95210","Starch-binding domain-containing protein 1 [OS=Homo sapiens]",39,15,34,15,358,39,5.73,84.87,"other metabolic processes;transport","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","STBD1","ENSG00000118804","","Neutrophil degranulation; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle","Exercise-induced circadian regulation",4444.8,4529.7,4741,4578.3,4673.6,5107.1,0.9551849014555329,-0.06614806268936005,0.31082526220765305,0.5074836913140747,0.534169254990768,0.2723211121441251,4253]
["O95218-1","Zinc finger Ran-binding domain-containing protein 2 [OS=Homo sapiens]",35,13,50,13,330,37.4,10.01,133.31,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","ZRANB2","ENSANAG00000018241; ENSCANG00000036472; ENSCATG00000025001; ENSG00000132485; ENSGGOG00000023501; ENSMFAG00000003326; ENSMLEG00000036639; ENSMNEG00000042080; ENSNLEG00000009455; ENSPANG00000013398; ENSPPAG00000037049; ENSPTRG00000000856; ENSSBOG00000013268","","","",8232,7788.9,8096.4,7434.9,8154.6,6001,{"$f":"AVERAGE(S770:U770)/AVERAGE(V770:X770)","v":1.117032954308608},{"$f":"LOG(Y770,2)","v":0.159671748324629},{"$f":"TTEST(V770:X770,S770:U770,2,2)","v":0.262525859905717},0.5808279103106112,{"$f":"AA770*7309/AE770","v":0.501385291364224},0.2998284106511375,3827]
["O95219","sorting nexin-4 [OS=Homo sapiens]",11,5,6,5,450,51.9,5.99,13.91,"transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","SNX4","ENSG00000114520","Endocytosis","","",343.2,360.1,377.5,334.1,334.5,251.1,1.1751658149396542,0.23286433424852984,0.14229106530140959,{"$f":"-LOG10(AA771)","v":0.8468223691505559},0.3803969993738122,{"$f":"-LOG10(AC771)","v":0.4197629174983864},2734]
["O95229","ZW10 interactor [OS=Homo sapiens]",8,2,2,2,277,31.3,5.15,5.15,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","ZWINT","ENSG00000122952","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",171.9,230.8,209.9,325.7,411.9,405.6,0.5358642407277818,-0.9000605494968584,0.005636345356624347,2.2490024041572383,0.0820638410588991,1.0858481594182845,502]
["O95232-1","Luc7-like protein 3 [OS=Homo sapiens]",49,22,71,22,432,51.4,9.79,189.39,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity","LUC7L3","ENSCANG00000028098; ENSCATG00000034891; ENSG00000108848; ENSGGOG00000024399; ENSMLEG00000034172; ENSMMUG00000010117; ENSPPAG00000025115; ENSPTRG00000009409; ENSRROG00000039925","","","",7377.4,7523.7,7337.9,7671.2,8059.8,11482.6,0.8172016932710117,-0.2912359014976213,0.24315432111150173,0.6141180081513009,0.4861091173424415,0.31326623332912173,3656]
["O95235","kinesin-like protein KIF20A [OS=Homo sapiens]",19,14,24,14,890,100.2,6.92,75.44,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","KIF20A","ENSG00000112984","","COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Mitotic Telophase/Cytokinesis","",1397.1,1412.9,1482.5,1083.2,1061.5,1186.7,1.2884973284505015,0.36568954594009484,2.362962355251155E-3,2.626543197130612,0.05482822810962124,1.2609957890362395,315]
["O95236-1","Apolipoprotein L3 [OS=Homo sapiens]",24,10,18,10,402,44.3,8.16,43.95,"protein metabolism;other metabolic processes;stress response;transport","non-structural extracellular;other cell component","transporter activity;other molecular function","APOL3","ENSG00000128284","","","",1217.3,1270.5,1248.3,1437.7,1525.3,1517.7,0.8338206083870825,-0.26219106520876967,1.4864620398327669E-3,2.8278461770084293,0.044164841663161356,1.3549233222278354,246]
["O95239-1","Chromosome-associated kinesin KIF4A [OS=Homo sapiens]",32,33,76,33,1232,139.8,6.27,222.16,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","KIF4A","ENSG00000090889; ENSGGOG00000006631; ENSPTRG00000021996","","MHC class II antigen presentation; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","Retinoblastoma gene in cancer",6569.9,6534.5,6557.6,5325.5,5550,5923.6,1.17041984392021,0.22702613501503213,0.005466163721751229,2.2623173645225614,0.08120363951682873,1.0904245054059487,492]
["O95243","Methyl-CpG-binding domain protein 4 [OS=Homo sapiens]",24,11,15,1,580,66,8.82,29.4,"DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus","nucleic acid binding activity;other molecular function","MBD4","ENSG00000129071","Base excision repair","Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Displacement of DNA glycosylase by APEX1","Base excision repair; DNA repair pathways, full network",1627.5,1653.8,1674,2233.3,2174.8,2735.7,0.6936504381421652,-0.5277192882942777,0.01502184251990226,1.8232767952180098,0.12751991518927483,0.8944219847876915,861]
["O95243-2","Isoform 2 of Methyl-CpG-binding domain protein 4 [OS=Homo sapiens]",24,11,15,1,574,65.3,8.84,29.64,"","","","MBD4","","","","",161.4,149.7,137.6,164.8,192.8,122.9,0.9338189386056194,-0.09878524698476729,0.6469671582562131,0.1891177646946843,0.7507037561032961,0.12453141116058392,6299]
["O95248-1","Myotubularin-related protein 5 [OS=Homo sapiens]",26,36,70,36,1867,208.2,6.9,212.66,"","","","","","","","",5493.4,5477.8,5833.5,5126.6,5074.6,8227.3,0.9118864801801557,-0.13307385895652102,0.6330085704132795,0.1985904099542123,0.7416895865903591,0.12977781849136427,6238]
["O95249-1","Golgi SNAP receptor complex member 1 [OS=Homo sapiens]",24,7,11,7,250,28.6,9.42,33.73,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","GOSR1","ENSG00000108587","SNARE interactions in vesicular transport","Intra-Golgi traffic; COPI-mediated anterograde transport","",1580.6,1516.7,1542.2,1982.7,1958.6,1478.4,0.8560436924553019,-0.22424366125169817,0.19071000266966057,0.7196265277703942,0.43613873889629196,0.360375336528375,3196]
["O95251-1","Histone acetyltransferase KAT7 [OS=Homo sapiens]",9,7,13,7,611,70.6,8.85,30.93,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","KAT7","ENSAMEG00000012243; ENSANAG00000032052; ENSCANG00000040077; ENSCATG00000030056; ENSCJAG00000007037; ENSDLEG00000005028; ENSECAG00000010150; ENSG00000136504; ENSGGOG00000007469; ENSMLEG00000043692; ENSMNEG00000044419; ENSPANG00000022824; ENSPCTG00005022544; ENSPPAG00000041097; ENSPPYG00000008925; ENSPTRG00000009383; ENSRFEG00010021504","","HATs acetylate histones","Androgen receptor signaling pathway; Androgen receptor signaling pathway",1507,1479.3,1429.2,1739,1705.1,1827.9,0.8375379362670713,-0.2557735561014142,0.002697661809564978,2.569012496267439,0.057652661304416444,1.239180640439601,342]
["O95260","Arginyl-tRNA--protein transferase 1 [OS=Homo sapiens]",22,8,18,8,518,59.1,7.93,49.56,"protein metabolism;other metabolic processes","nucleus;other cell component","other molecular function","ATE1","ENSG00000107669","","","",890.8,912.6,963.4,944.3,990.5,965.2,0.9540689655172415,-0.06783453870526021,0.15434853995431658,0.8114974743307857,0.39390135423397343,0.4046125260826306,2864]
["O95263-4","Isoform 4 of High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [OS=Homo sapiens]",1,1,2,1,865,96.7,6.83,1.82,"","","","PDE8B","","","","",166.5,170.9,168.8,138.1,132.6,46.3,1.5968454258675078,0.6752246670839145,0.10137851010382545,0.994054095618455,0.3284466003319416,0.4835352290457868,2256]
["O95271","Tankyrase-1 [OS=Homo sapiens]",1,1,1,1,1327,142,7.05,0,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","TNKS","ENSG00000173273","","Degradation of AXIN; Ub-specific processing proteases; Regulation of PTEN stability and activity; XAV939 stabilizes AXIN","NAD+ biosynthetic pathways; Regulation of Wnt / B-catenin signaling by small molecule compounds",49.7,40.4,76.3,44,56,77.3,0.9385222786238013,-0.09153710275759669,0.8146052600832775,0.08905278990707213,0.8745519750218382,0.058214375099630664,6808]
["O95273-1","Cyclin-D1-binding protein 1 [OS=Homo sapiens]",8,3,8,3,360,40.2,4.82,20.1,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","","CCNDBP1","ENSG00000166946","","","",765.6,520.4,567.4,509.4,526,410.2,1.2820973990038738,0.3585058654841942,0.1783761859064342,0.7486631265281257,0.42110837945417556,0.3756061166550077,3096]
["O95292","Vesicle-associated membrane protein-associated protein B/C [OS=Homo sapiens]",44,10,36,9,243,27.2,7.3,130.67,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","VAPB","ENSG00000124164","Cholesterol metabolism; Amyotrophic lateral sclerosis; Pathways of neurodegeneration","RHOA GTPase cycle; Sphingolipid de novo biosynthesis; RHOC GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOD GTPase cycle","Ciliary landscape",4915,5049.3,5150.4,5028,5651.5,3906.3,1.0362612952323491,0.0513878271607214,0.7493915411325148,0.12529121337753613,0.8280125130971354,0.08196310001708294,6615]
["O95295","SNARE-associated protein Snapin [OS=Homo sapiens]",14,2,4,2,136,14.9,9.31,12.19,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SNAPIN","ENSG00000143553","","Golgi Associated Vesicle Biogenesis","",141.6,180.3,126.5,138.7,204.6,292,0.7058082795529672,-0.5026517409953614,0.2573400638624458,0.5894925956011723,0.49667243907330766,0.30392993883802566,3787]
["O95297-1","Myelin protein zero-like protein 1 [OS=Homo sapiens]",3,1,2,1,269,29.1,8.72,4.69,"cell-cell signaling;signal transduction","plasma membrane;other membranes","other molecular function","MPZL1","ENSG00000197965","Cell adhesion molecules","","",396.4,429.9,412.6,391.6,390,223.7,1.232368447229683,0.3014336501254072,0.2404653771591982,0.6189474456566951,0.4833777342289823,0.31571335832265196,3636]
["O95298-1","NADH dehydrogenase [ubiquinone] 1 subunit C2 [OS=Homo sapiens]",30,5,22,5,119,14.2,8.98,49.67,"cell organization and biogenesis;other metabolic processes;transport","plasma membrane;other membranes;mitochondrion;other cytoplasmic organelle;other cell component","transporter activity","NDUFC2","ENSG00000151366; ENSGGOG00000041901","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Neutrophil degranulation; Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",2880,3272.5,2672.7,2414.3,3329.6,2422.1,1.0807249571393585,0.11199940608859153,0.565296781362012,0.24772348728125201,0.6954644293847745,0.1577250777739661,5941]
["O95299","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [OS=Homo sapiens]",35,10,24,10,355,40.7,8.48,57.68,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;other cell component","transporter activity","NDUFA10","ENSG00000130414","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",2499.6,2444.6,2483.7,2313.7,2151,1836.9,1.1787323854259235,0.23723621191963457,0.05610784817393842,1.2509763868678245,0.24395732439221648,0.6126861384233226,1681]
["O95319-1","CUGBP Elav-like family member 2 [OS=Homo sapiens]",17,9,36,8,508,54.3,8.76,79.13,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","CELF2","ENSANAG00000024646; ENSCATG00000032144; ENSG00000048740; ENSPANG00000023401; ENSPPYG00000002083; ENSSBOG00000028844","","","mRNA processing",4838.9,4818.1,4913,4932.1,4745.6,3931.1,1.070630768326377,0.09846101925819646,0.3579109755615169,0.4462249834967907,0.5587294575777717,0.25279843097342325,4682]
["O95336","6-phosphogluconolactonase [OS=Homo sapiens]",38,6,21,6,258,27.5,6.05,60.85,"other metabolic processes","cytosol;other cell component","other molecular function","PGLS","ENSG00000130313","Pentose phosphate pathway; Metabolic pathways; Carbon metabolism","Pentose phosphate pathway","Pentose phosphate metabolism",1422.9,1359,1330.7,1278.8,1449.5,1581.1,0.9543323896598136,-0.06743625696486856,0.5137391773520739,0.28925731405170296,0.6592204436914164,0.18096933279652994,5696]
["O95340","bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [OS=Homo sapiens]",29,15,34,13,614,69.5,8.03,114.36,"other metabolic processes;developmental processes","cytosol","kinase activity;other molecular function","PAPSS2","ENSG00000198682","Purine metabolism; Selenocompound metabolism; Sulfur metabolism; Metabolic pathways","Transport and synthesis of PAPS; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se; Defective PAPSS2 causes SEMD-PA","RANKL/RANK signaling pathway; Proteoglycan biosynthesis; Sulfation biotransformation reaction",3162.3,3076.7,3127.4,3110.3,3173.4,3454.9,0.9617809541412522,-0.05621973764653175,0.3178103791938998,0.497831923513062,0.5385754837765392,0.2687534197750408,4313]
["O95347-1","structural maintenance of chromosomes protein 2 [OS=Homo sapiens]",48,65,205,65,1197,135.6,8.43,553.65,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMC2; SMC2L1","ENSG00000136824","","Condensation of Prophase Chromosomes; Condensation of Prometaphase Chromosomes","Retinoblastoma gene in cancer",25465.9,25113.5,25605.7,25197.5,25235.8,21413.2,1.0603870752228712,0.08459099079733938,0.3204752438813768,0.4942055132932615,0.541209232331096,0.26663480350780155,4328]
["O95352","Ubiquitin-like modifier-activating enzyme ATG7 [OS=Homo sapiens]",6,3,3,3,703,77.9,6.24,2.83,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;cytosol;cytoskeleton;other cell component","other molecular function","ATG7","ENSG00000197548","Autophagy; Autophagy; Ferroptosis; Neutrophil extracellular trap formation","Neutrophil degranulation; Antigen processing: Ubiquitination & Proteasome degradation; Signaling by BRAF and RAF1 fusions; Macroautophagy","Nanoparticle triggered autophagic cell death; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Senescence and autophagy in cancer",52.9,72.7,64.5,55.8,66.6,49.9,1.1033081834010448,0.14183583042360395,0.4755084940428319,0.32284172082334317,0.6317926891399852,0.19942540388913613,5501]
["O95359","Transforming acidic coiled-coil-containing protein 2 [OS=Homo sapiens]",1,4,12,1,2948,309.2,4.79,28.04,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","TACC2","ENSG00000138162","","","",64,57.4,64,62.6,57,34,1.2070312500000002,0.2714630279043748,0.3052417597733904,0.515356051324932,0.5296799672800833,0.27598645195440796,4212]
["O95363","phenylalanine--tRNA ligase, mitochondrial [OS=Homo sapiens]",7,3,6,3,451,52.3,7.46,19.74,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","FARS2","ENSG00000145982","Aminoacyl-tRNA biosynthesis","Mitochondrial tRNA aminoacylation","",988.7,966.4,974.3,986,922.1,1049,0.9906327144837848,-0.013577829816307398,0.8162448219596182,0.0881795607569894,0.8752836566465448,0.05785118063166014,6816]
["O95365","Zinc finger and BTB domain-containing protein 7A [OS=Homo sapiens]",11,3,4,3,584,61.4,5.19,20.38,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB7A","ENSG00000178951","","","IL-18 signaling pathway",95.6,83.1,94.4,110.5,105,441.6,0.41561406178663834,-1.2666836280209481,0.31445508377250403,0.5024413796713262,0.5364967804139197,0.27043287994717125,4284]
["O95372","acyl-protein thioesterase 2 [OS=Homo sapiens]",29,5,22,5,231,24.7,7.23,67.04,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes","cytosol;ER/Golgi;other cell component","other molecular function","LYPLA2","ENSG00000011009","Glycerophospholipid metabolism","L1CAM interactions","",2894.5,2755,2583.2,2578.5,2839.4,3622.7,0.9106364621817138,-0.1350528683925525,0.4557195789024295,0.34130231259238447,0.6181986641050217,0.20887193775935953,5388]
["O95373","Importin-7 [OS=Homo sapiens]",36,27,146,26,1038,119.4,4.82,481.3,"stress response;transport;signal transduction;other biological processes","cytosol;nucleus","transporter activity;enzyme regulator activity;other molecular function","IPO7","ENSG00000205339","Nucleocytoplasmic transport","","",14211.6,14380.8,14684.9,13352.1,12832.8,13001.7,1.1043902762679079,0.14325009071896636,2.7160569725745067E-3,2.566061124444842,0.05787656096952498,1.2374972826036397,343]
["O95376","E3 ubiquitin-protein ligase ARIH2 [OS=Homo sapiens]",25,9,23,9,493,57.8,5.63,62.16,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","other molecular function","ARIH2","ENSG00000177479","","Antigen processing: Ubiquitination & Proteasome degradation","Modulators of TCR signaling and T cell activation",1298.3,1356.4,1360.1,1311.3,1263.7,1596.6,0.9624125035957425,-0.055272708858835756,0.6473591880314244,0.18885468363508795,0.7508010639989974,0.12447512058909581,6302]
["O95379","Tumor necrosis factor alpha-induced protein 8 [OS=Homo sapiens]",24,4,10,4,198,23,7.93,27.88,"other biological processes","nucleus;other cell component","enzyme regulator activity","TNFAIP8","ENSG00000145779","","PI Metabolism","",225.9,211.3,214.5,246.4,301.5,73.8,1.0482547852662056,0.06798941607895247,0.8913551805725753,0.049949207045190236,0.9305692065140627,0.0312513228131631,7001]
["O95391","Pre-mRNA-splicing factor SLU7 [OS=Homo sapiens]",16,8,13,8,586,68.3,7.14,34.85,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SLU7","ENSG00000164609","Spliceosome","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway","",594.3,593.4,584.9,971.9,921.8,1091.9,0.5937165058949625,-0.7521538729012243,1.3252748092555829E-3,2.877694056996311,0.04248435781074147,1.371770942112792,228]
["O95394","phosphoacetylglucosamine mutase [OS=Homo sapiens]",23,14,33,14,542,59.8,6.25,91.25,"protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol","other molecular function","PGM3","ENSG00000013375","Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars","Synthesis of UDP-N-acetyl-glucosamine","Glucuronidation",5050.3,5267.5,5179.9,5312,4315.6,2833,1.2437362566810586,0.31468058392552994,0.2340137893392435,0.6307585508911479,0.4801815795285038,0.3185945041343997,3562]
["O95396","Adenylyltransferase and sulfurtransferase MOCS3 [OS=Homo sapiens]",14,6,11,6,460,49.6,6.21,33.72,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;other cell component","other molecular function","MOCS3","ENSG00000124217","Sulfur relay system","Molybdenum cofactor biosynthesis","",1100.5,1034.3,1028.7,1097.1,1073.9,956,1.0116725295810682,0.016742376589807373,0.8175617106180451,0.08747945631979245,0.8764386246563937,0.057278491328691804,6818]
["O95400","CD2 antigen cytoplasmic tail-binding protein 2 [OS=Homo sapiens]",50,10,33,10,341,37.6,4.61,102.7,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","CD2BP2","ENSG00000169217","","mRNA Splicing - Major Pathway","mRNA processing; Ciliary landscape",1991.8,2086.4,1773.8,2214,2251.9,2548.7,0.8342599720582785,-0.2614310685855003,0.05102616229918305,1.2922070939245345,0.23193421657010507,0.6346351764529939,1608]
["O95425","Supervillin [OS=Homo sapiens]",1,2,2,2,2214,247.6,6.98,2.04,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","SVIL","ENSG00000197321","","","",241.9,232,237.5,238.3,246.5,64,1.2962827988338195,0.3743804928890383,0.4144565400281513,0.3825210029074603,0.589809745145202,0.22928805608428424,5136]
["O95427","GPI ethanolamine phosphate transferase 1 [OS=Homo sapiens]",2,2,2,2,931,105.7,8.65,5.83,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;ER/Golgi","other molecular function","PIGN","ENSG00000197563","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways","Synthesis of glycosylphosphatidylinositol (GPI)","",206.6,213.3,242.5,227.5,234.3,316.6,0.8509763617677285,-0.23280903728178662,0.27608837560502314,0.5589518784634941,0.5111271371066651,0.2914710605771203,3948]
["O95433","activator of 90 kDa heat shock protein ATPase homolog 1 [OS=Homo sapiens]",71,19,101,19,338,38.3,5.53,313.06,"other biological processes","cytosol;ER/Golgi","other molecular function","AHSA1","ENSG00000100591","","","T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection",12193.6,12076.8,12432.7,12479.5,11762.3,13363.3,0.9760138917327705,-0.03502641288675216,0.5608919519419451,0.2511207914974883,0.6931956842650788,0.15914414980361422,5914]
["O95453","poly(A)-specific ribonuclease PARN [OS=Homo sapiens]",26,16,30,16,639,73.4,6.2,64.2,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PARN","ENSG00000140694; ENSG00000274829","RNA degradation","Deadenylation of mRNA; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA","Lung fibrosis",2386.5,2405.7,2485.3,2446.3,2346.3,2285.3,1.0282004549371988,0.04012155553534103,0.2992551527394934,0.5239583629363799,0.526035572720769,0.2789848860478573,4158]
["O95456","Proteasome assembly chaperone 1 [OS=Homo sapiens]",48,9,19,9,288,32.8,7.17,59.26,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes","cytosol;ER/Golgi;nucleus;other cell component","other molecular function","PSMG1","ENSG00000183527","","","",1612.2,1571.8,1541.9,1557.1,1473.4,791.7,1.2364345141541522,0.30618583163492763,0.28328125605597326,0.5477821606040516,0.5169794508147587,0.28652671914033506,4005]
["O95461-1","LARGE xylosyl- and glucuronyltransferase 1 [OS=Homo sapiens]",5,4,6,3,756,88,7.84,7.11,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","LARGE; LARGE1","ENSG00000133424; ENSPTRG00000014294","Mannose type O-glycan biosynthesis; Metabolic pathways","Defective LARGE causes MDDGA6 and MDDGB6; O-linked glycosylation","",107,124,113.7,115.9,116.4,174,0.848387890721142,-0.23720406586381862,0.36061686093363715,0.44295397134836895,0.5592507185580212,0.25239344922403173,4713]
["O95466-2","Isoform 2 of Formin-like protein 1 [OS=Homo sapiens]",42,47,196,5,1104,122.3,5.83,583.57,"","","","FMNL1","","","","",23340.9,22729.7,23123.4,21633.8,22308.1,22747.6,1.0375546375366438,0.05318731065489654,0.08703816286584916,1.0602902843008177,0.30250210764930646,0.5192715951031658,2103]
["O95470","sphingosine-1-phosphate lyase 1 [OS=Homo sapiens]",5,3,8,3,568,63.5,9.16,14.54,"other metabolic processes;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","SGPL1","ENSG00000166224","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway","Sphingolipid de novo biosynthesis","Sphingolipid pathway; Kennedy pathway from sphingolipids; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway",683.2,689.4,676.8,597.9,558.2,338.6,1.371111259784572,0.45534564436788155,0.08379127267467326,1.0768012131908573,0.29657647069210014,0.5278633072993042,2065]
["O95476","CTD nuclear envelope phosphatase 1 [OS=Homo sapiens]",4,1,1,1,244,28.4,9.76,3.48,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","CTDNEP1","ENSG00000175826; ENSG00000288307","","Depolymerisation of the Nuclear Lamina","Development of ureteric collection system",137.1,143.8,152.4,144.7,164.4,125,0.9981571066574519,-0.002661185981012409,0.9836154023557511,0.007174679297149015,0.989436412856893,0.004612110939871936,7266]
["O95478","Ribosome biogenesis protein NSA2 homolog [OS=Homo sapiens]",26,6,10,6,260,30,10.27,28.21,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","NSA2","ENSG00000164346","","","",822.2,833.1,857.9,2118.4,1893.5,2250.7,0.4013029732060167,-1.3172362499738253,2.8320276108979061E-4,3.5479025168007197,0.021561760216721664,1.666315787956315,96]
["O95479","GDH/6PGL endoplasmic bifunctional protein [OS=Homo sapiens]",3,2,2,2,791,88.8,7.3,6.86,"other metabolic processes;other biological processes","mitochondrion;ER/Golgi","other molecular function","H6PD","ENSG00000049239","Pentose phosphate pathway; Metabolic pathways; Carbon metabolism","","Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism",96.8,87,113.7,78.6,87.6,236.5,0.7387633474050163,-0.43681580386308566,0.5354820288007421,0.2712550998529228,0.6745670714416795,0.1709748624355951,5802]
["O95486-1","Protein transport protein Sec24A [OS=Homo sapiens]",9,9,26,9,1093,119.7,7.66,77.11,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi","other molecular function","SEC24A","ENSG00000113615","Protein processing in endoplasmic reticulum; Pathogenic Escherichia coli infection","MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Sterol regulatory element-binding proteins (SREBP) signaling",1929.4,2090.7,2069.6,2292.8,2132.7,2255.6,0.9114816422445405,-0.13371449502390645,0.048044207800720155,1.3183589632881416,0.2264056188365336,0.6451127992177735,1551]
["O95487-1","Protein transport protein Sec24B [OS=Homo sapiens]",13,13,27,13,1268,137.3,6.67,85.07,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","SEC24B","ENSG00000138802","Protein processing in endoplasmic reticulum; Pathogenic Escherichia coli infection","COPII-mediated vesicle transport; MHC class II antigen presentation; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Sterol regulatory element-binding proteins (SREBP) signaling",2049.4,2058.4,2259.3,2329.4,2196.8,2879.7,0.8597334557582468,-0.2180386463047471,0.19062799382167941,0.719813322640154,0.43622417246169526,0.36029027255864515,3194]
["O95503","Chromobox protein homolog 6 [OS=Homo sapiens]",2,1,1,1,412,43.9,10.01,2.47,"cell organization and biogenesis;other biological processes","nucleus;other cell component","","CBX6","ENSG00000183741","","Regulation of PTEN gene transcription; Oxidative Stress Induced Senescence; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","",63.3,62.6,48.4,250.5,265.5,195.1,0.2451132048938265,-2.028479886807964,1.2329817039977006E-3,2.909043367777174,0.04115006061424289,1.3856295207333196,219]
["O95544","NAD kinase [OS=Homo sapiens]",7,2,3,2,446,49.2,6.47,11.27,"other metabolic processes;other biological processes","cytosol","kinase activity;other molecular function","NADK","ENSG00000008130","Nicotinate and nicotinamide metabolism; Metabolic pathways; Biosynthesis of cofactors","Nicotinate metabolism","NAD+ metabolism",216.1,216.3,226.6,266,220.1,432.5,0.7173960374482908,-0.4791583183255301,0.25155485236543773,0.599367300937284,0.49279400051969563,0.30733458809414005,3731]
["O95551-1","Tyrosyl-DNA phosphodiesterase 2 [OS=Homo sapiens]",21,5,10,5,362,40.9,5.1,40.15,"DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TDP2","ENSG00000111802","","Nonhomologous End-Joining (NHEJ)","Oxidative damage response",773.4,709.6,740.7,1262.3,1310.1,1721.3,0.5178983161375968,-0.9492592270999833,0.00931714219725357,2.0307172763033496,0.1008873960292242,0.9961630872504017,675]
["O95562","Vesicle transport protein SFT2B [OS=Homo sapiens]",17,2,2,2,160,17.8,9.13,7.37,"transport","other membranes","","SFT2D2","ENSG00000213064","","","TYROBP causal network in microglia",244.7,189.8,209.8,210.4,178.2,136.5,1.2270043801180728,0.2951403990931922,0.21146906391380663,0.674753157150483,0.4567456820762449,0.340325549633496,3384]
["O95563","Mitochondrial pyruvate carrier 2 [OS=Homo sapiens]",28,4,16,4,127,14.3,10.43,39.48,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MPC2","ENSG00000143158","Diabetic cardiomyopathy","Pyruvate metabolism","Glycolysis and gluconeogenesis",2683.1,2503.3,2089.2,1886.3,2199,1261.4,1.3607645837619464,0.44441749798348557,0.12062754570620814,0.9185535082637565,0.35280781575297127,0.4524618025062336,2499]
["O95568","histidine protein methyltransferase 1 homolog [OS=Homo sapiens]",8,2,3,2,372,42.1,6.76,10.13,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","METTL18","ENSG00000171806","","","",121.3,125,111.7,151.2,167,193.2,0.7000391083300743,-0.51449257309003,0.016508845291961262,1.782283302319708,0.1337728938347504,0.8736318779776767,902]
["O95571","Persulfide dioxygenase ETHE1, mitochondrial [OS=Homo sapiens]",20,4,16,4,254,27.9,6.83,64.11,"other metabolic processes","mitochondrion;nucleus;other cell component","other molecular function","ETHE1","ENSG00000105755","Sulfur metabolism; Metabolic pathways","Sulfide oxidation to sulfate","",2307.1,2360.2,2385.8,2091.7,2255.7,2730.3,0.9965242946154825,-5.0231174256093174E-3,0.9681262074611603,0.014068023237953628,0.9795175041990062,0.008987798659430038,7224]
["O95573","long-chain-fatty-acid--CoA ligase 3 [OS=Homo sapiens]",27,15,45,12,720,80.4,8.38,138.07,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ACSL3","ENSG00000123983","Fatty acid biosynthesis; Fatty acid degradation; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; Peroxisome; Ferroptosis; Thermogenesis; Adipocytokine signaling pathway","Synthesis of very long-chain fatty acyl-CoAs; Intracellular metabolism of fatty acids regulates insulin secretion","Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Ciliary landscape; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters",4043.2,4103.8,4194.9,3863.6,3917.7,4242.2,1.026481473780513,0.03770758952525521,0.44759521830333365,0.3491145617227065,0.6129798483378426,0.21255380264232102,5337]
["O95602","DNA-directed RNA polymerase I subunit RPA1 [OS=Homo sapiens]",21,29,61,28,1720,194.7,7.03,192.23,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POLR1A","ENSG00000068654","RNA polymerase","B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","Pyrimidine metabolism; Eukaryotic transcription initiation",4343.1,4299.3,4532.1,4977.8,4693.8,5136.2,0.8897000229608721,-0.16860910525463288,0.021145435902160392,1.6747833576699949,0.15063546881958118,0.8220727565618194,1026]
["O95613","Pericentrin [OS=Homo sapiens]",23,67,104,67,3336,377.8,5.55,318.42,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton","other molecular function","PCNT","ENSG00000160299","","Late endosomal microautophagy; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Chaperone Mediated Autophagy","",9264.4,9233.1,9143.9,10737.7,10715.2,9884,0.8820719343649182,-0.18103178023865202,0.012160286935870453,1.9150561772676447,0.11468327382487374,0.9404999178899819,775]
["O95619","YEATS domain-containing protein 4 [OS=Homo sapiens]",22,5,8,5,227,26.5,8.41,21.32,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","other membranes;nucleus","cytoskeletal activity;other molecular function","YEATS4","ENSG00000127337","","HATs acetylate histones; Activation of the TFAP2 (AP-2) family of transcription factors","",819.5,886.1,893.5,1176.8,1013.7,851.9,0.8542926636865632,-0.22719770171824685,0.2012014219269342,0.6963689543674071,0.4469851650042438,0.3497068904334084,3290]
["O95620","tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like [OS=Homo sapiens]",7,1,1,1,317,35.8,7.33,4.6,"RNA metabolism OR transcription;other metabolic processes","","other molecular function","DUS4L","ENSG00000105865; ENSG00000284103","","","",8.7,10.9,16.2,11.4,11.8,26.7,0.7174348697394788,-0.47908022807300443,0.4413266577521328,0.355239838777625,0.609995563825707,0.21467332337123593,5288]
["O95625","Zinc finger and BTB domain-containing protein 11 [OS=Homo sapiens]",3,3,4,3,1053,119.3,8.66,12.07,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZBTB11","ENSG00000066422","","","",412.6,404.6,427.3,469.2,517.3,587.7,0.7905602845889975,-0.33905261464217784,0.03498494999706202,1.4561187424754525,0.1944524711243546,0.7111865334172562,1315]
["O95628-6","Isoform 6 of CCR4-NOT transcription complex subunit 4 [OS=Homo sapiens]",14,7,14,7,767,84.7,7.3,39.71,"","","","CNOT4","","","","",833,851.1,835.5,1032.5,979.5,1323.2,0.7554569441112977,-0.40457856092305144,0.0639009451956358,1.1944927178946043,0.25549891052237533,0.592610947408444,1828]
["O95630","STAM-binding protein [OS=Homo sapiens]",21,10,22,10,424,48,6.29,53.17,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle","other molecular function","STAMBP","ENSG00000124356","Endocytosis","Metalloprotease DUBs","EGF/EGFR signaling pathway",3389.3,3335.6,3462.3,4026.2,3963,4309.2,{"$f":"AVERAGE(S834:U834)/AVERAGE(V834:X834)","v":0.8283353932218827},{"$f":"LOG(Y834,2)","v":-0.27171306126281025},{"$f":"TTEST(V834:X834,S834:U834,2,2)","v":0.003341252081822165},2.476090757640989,{"$f":"AA834*7309/AE834","v":0.0637629542194209},1.1954315697256388,383]
["O95639","Cleavage and polyadenylation specificity factor subunit 4 [OS=Homo sapiens]",18,5,10,5,269,30.2,8.31,21.81,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CPSF4","ENSG00000160917","mRNA surveillance pathway; Influenza A","mRNA Splicing - Major Pathway; Transport of Mature mRNA Derived from an Intronless Transcript; tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Inhibition of Host mRNA Processing and RNA Silencing","mRNA processing",1109.3,1085.2,1131.6,1235.5,1197.8,788.6,1.032341165150998,0.04591982728494226,0.8209213900666151,{"$f":"-LOG10(AA835)","v":0.0856984281361317},0.8784940614929561,{"$f":"-LOG10(AC835)","v":0.05626116993369131},6830]
["O95671-1","N-acetylserotonin O-methyltransferase-like protein [OS=Homo sapiens]",24,12,24,12,621,68.8,6.07,76.91,"other metabolic processes","cytosol","other molecular function","ASMTL","ENSG00000169093","Pyrimidine metabolism","","",2616,2463.8,2640.2,2241,2038.3,2061.1,1.21758879565958,0.2840269882307604,5.5593099583333755E-3,2.254979111275153,0.08208686158678513,1.085726348324749,495]
["O95674-1","phosphatidate cytidylyltransferase 2 [OS=Homo sapiens]",31,9,25,8,445,51.4,7.09,87.87,"cell organization and biogenesis;other metabolic processes","other membranes;mitochondrion;ER/Golgi","other molecular function","CDS2","ENSG00000101290","Glycerophospholipid metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of PG","",1867.4,1844.8,2020.3,1898.8,1987.2,2023.5,0.9700482274304086,-0.043871620015348105,0.42447626916725006,0.3721465844725562,0.5967488077213754,0.22420844002216272,5199]
["O95684","FGFR1 oncogene partner [OS=Homo sapiens]",34,7,10,7,399,43,4.81,32.64,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","CEP43","ENSG00000213066","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease","Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome",463.6,426.5,428.2,431.5,506.1,464.4,0.940299572039943,-0.08880763358351065,0.3225318808427919,0.4914273508278182,0.542676224005517,0.26545920552463576,4344]
["O95696","Bromodomain-containing protein 1 [OS=Homo sapiens]",5,4,5,4,1058,119.4,8.6,10.81,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","other molecular function","BRD1","ENSG00000100425","","HATs acetylate histones; Regulation of TP53 Activity through Acetylation","Pathways affected in adenoid cystic carcinoma",387.9,402.4,389.2,396.5,423.5,528.8,0.8744810201660737,-0.1935010228152572,0.23712563767567005,0.6250214882017423,0.48169852300485616,0.31722468532730186,3598]
["O95707","Ribonuclease P protein subunit p29 [OS=Homo sapiens]",12,2,3,2,220,25.4,10.07,9.23,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POP4","ENSG00000105171","Ribosome biogenesis in eukaryotes","tRNA processing in the nucleus","",148.5,150,150.8,164.1,156.1,164.4,0.9271564176640529,-0.10911534292790807,0.013676156229289246,1.8640359466930292,0.12234886888601604,0.9124000413414717,817]
["O95714","E3 ubiquitin-protein ligase HERC2 [OS=Homo sapiens]",4,14,22,14,4834,526.9,6.28,62.99,"protein metabolism;DNA metabolism;other metabolic processes;stress response;transport","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","HERC2","ENSG00000128731","Ubiquitin mediated proteolysis","SUMOylation of DNA damage response and repair proteins; Antigen processing: Ubiquitination & Proteasome degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)","Prader-Willi and Angelman syndrome",1287.3,1192.1,1269.2,1443.4,1392.7,1602.6,0.8445265505666071,-0.24378531511865703,0.029851329573422597,1.525036320697383,0.1794271117205146,0.7461119337501262,1216]
["O95716","ras-related protein Rab-3D [OS=Homo sapiens]",31,7,25,4,219,24.3,4.93,56.46,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB3D","ENSG00000105514","Pancreatic secretion","Neutrophil degranulation; RAB geranylgeranylation","",1013.5,1012.7,1094.4,1021.7,1067.2,958.1,1.0241549064653759,0.03443394374350872,0.5875722925160026,0.23093869193406366,0.7106678613270665,0.14833332429854715,6043]
["O95721","Synaptosomal-associated protein 29 [OS=Homo sapiens]",22,6,7,6,258,29,5.81,17.87,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","SNAP29","ENSG00000099940","SNARE interactions in vesicular transport; Autophagy","Intra-Golgi traffic; Neutrophil degranulation","Ciliary landscape; 22q11.2 copy number variation syndrome",1029.1,1217.2,959.7,1131.8,1162.4,1261.6,0.9016255132459644,-0.14939975493994978,0.24813280536380225,0.6053158143387054,0.4913580803045328,0.3086018976503896,3691]
["O95747","Serine/threonine-protein kinase OSR1 [OS=Homo sapiens]",31,13,59,11,527,58,6.43,200.91,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol","kinase activity;other molecular function","OXSR1","ENSG00000172939","","","",4719.7,4644.2,4699.4,4489.1,4383.1,4095.8,1.084461752004935,0.11697917134502271,0.03796112898797615,1.4206608798602087,0.20311705107841704,0.6922536173217496,1366]
["O95749","geranylgeranyl pyrophosphate synthase [OS=Homo sapiens]",12,4,7,4,300,34.8,6.14,18.08,"other metabolic processes","cytosol","other molecular function","GGPS1","ENSG00000152904","Terpenoid backbone biosynthesis; Metabolic pathways","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways",1011.7,963.2,1010.2,997.2,1042.3,557.9,1.1492646492646492,0.2007110557886216,0.45216657312975933,0.3447015464618564,0.6164680997958237,0.2100893918031901,5361]
["O95757","Heat shock 70 kDa protein 4L [OS=Homo sapiens]",56,41,192,36,839,94.5,5.88,590.57,"stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","HSPA4L","ENSG00000164070","Protein processing in endoplasmic reticulum","Regulation of HSF1-mediated heat shock response","",17302,16975.7,17277.8,18043.3,18086.7,13930.3,1.0298679792170644,0.04245940737315362,0.7366602359146737,0.13273277223676241,0.8176537075626955,0.08743058965059207,6585]
["O95758-1","Isoform 1 of Polypyrimidine tract-binding protein 3 [OS=Homo sapiens]",17,8,57,3,521,56.5,9.22,133.39,"","","","PTBP3","","","","",1125.8,1130.5,1111.4,1111,1324.3,3166,0.601235427490047,-0.7339980730610195,0.31745244793813704,0.4983213196467217,0.538093678566754,0.26914210994143106,4312]
["O95772-1","STARD3 N-terminal-like protein [OS=Homo sapiens]",7,2,3,2,234,26.6,4.81,4.26,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","STARD3NL","ENSCANG00000042172; ENSCATG00000036966; ENSCSAG00000015104; ENSG00000010270; ENSGGOG00000013471; ENSMFAG00000043802; ENSMLEG00000030425; ENSMMUG00000023659; ENSMNEG00000034363; ENSPANG00000016262; ENSPPAG00000039214; ENSPTRG00000019094; ENSRBIG00000036179; ENSRROG00000026971","","Pregnenolone biosynthesis","",591.9,518.9,623.9,562,544.8,501.1,1.0788606256607995,0.10950849999227923,0.3051744671983357,0.5154518049856193,0.5298147697749728,0.27587593893731466,4210]
["O95777","U6 snRNA-associated Sm-like protein LSm8 [OS=Homo sapiens]",59,4,23,4,96,10.4,4.48,78.7,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","LSM8","ENSG00000128534","RNA degradation; Spliceosome","mRNA Splicing - Major Pathway","",953.7,1001.4,983.5,949.3,944.4,574.8,1.1904395381810815,0.2514943487212992,0.27760914585730895,0.5565662301122405,0.5118681248917939,0.2908419140415052,3964]
["O95782","AP-2 complex subunit alpha-1 [OS=Homo sapiens]",38,32,95,22,977,107.5,7.03,261.06,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","AP2A1","ENSG00000196961","Endocytosis; Synaptic vesicle cycle; Endocrine and other factor-regulated calcium reabsorption; Huntington disease","MHC class II antigen presentation; Recycling pathway of L1; Potential therapeutics for SARS; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Trafficking of GluR2-containing AMPA receptors; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation","Synaptic vesicle pathway; VEGFA-VEGFR2 signaling pathway; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; mBDNF and proBDNF regulation of GABA neurotransmission",11106.2,11234,11062,10116.4,10056.4,11456.9,1.0560391024891163,0.07866325507771671,0.2683903951976217,0.5712330301845303,0.5049331785069284,0.2967660914374904,3885]
["O95785-3","Isoform 3 of Protein Wiz [OS=Homo sapiens]",14,8,13,8,965,102.9,9.52,28.55,"","","","WIZ","","","","",485.4,484.1,482.8,553.4,560.3,717.5,0.793086500655308,-0.3344498679736748,0.07794455783720189,1.1082142022683643,0.28656779337631216,0.5427726204456857,1988]
["O95793","double-stranded RNA-binding protein Staufen homolog 1 [OS=Homo sapiens]",12,6,9,6,577,63.1,9.44,22.2,"cell organization and biogenesis;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","nucleic acid binding activity;other molecular function","STAU1","ENSG00000124214","","","",676.9,679.3,612.4,764.5,765.9,685.8,0.8882772312968144,-0.17091808295520927,0.07420428539595501,1.1295710129140482,0.2787045847682606,0.5548558869624084,1946]
["O95801","Tetratricopeptide repeat protein 4 [OS=Homo sapiens]",36,10,23,10,387,44.7,5.6,68.81,"stress response","nucleus;other cell component","other molecular function","TTC4","ENSG00000243725","","","",2231.8,2302.9,2198.8,3270.8,3444.9,2597.3,0.723021582733813,-0.4678893815445787,0.029831727737943216,1.5253215932579205,0.17945687081203865,0.7460399093082786,1215]
["O95816","BAG family molecular chaperone regulator 2 [OS=Homo sapiens]",33,8,15,8,211,23.8,6.7,43.88,"protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","BAG2","ENSG00000112208","Protein processing in endoplasmic reticulum","Regulation of HSF1-mediated heat shock response","Malignant pleural mesothelioma",1556.3,1917.5,1526.1,1806.5,1986.7,1400.3,0.9627226340618079,-0.054807885708980354,0.7782212064528106,0.10889693888828819,0.8499729225887017,0.07059490929467219,6692]
["O95817","BAG family molecular chaperone regulator 3 [OS=Homo sapiens]",4,2,3,2,575,61.6,6.95,7.24,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","BAG3","ENSG00000151929","","Regulation of HSF1-mediated heat shock response","",163,89.5,93.7,142.6,86.3,252.2,0.7196009145707754,-0.47473107471558296,0.4535783766641569,0.3433476576408959,0.6167822055885251,0.2098681643445659,5375]
["O95819","Mitogen-activated protein kinase kinase kinase kinase 4 [OS=Homo sapiens]",7,7,7,4,1239,142,7.46,21.82,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","other cell component","cytoskeletal activity;kinase activity;other molecular function","MAP4K4","ENSG00000071054","MAPK signaling pathway","Oxidative Stress Induced Senescence","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Insulin signaling; Malignant pleural mesothelioma",233.3,214.3,261.3,234.4,248,323.2,0.8799652432969218,-0.18448155331178118,0.35443261259958386,0.4504663239734626,0.5565086929087774,0.25452804740685103,4655]
["O95822","Malonyl-CoA decarboxylase, mitochondrial [OS=Homo sapiens]",18,6,6,6,493,55,8.95,22.43,"other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","MLYCD","ENSG00000103150","beta-Alanine metabolism; Propanoate metabolism; Metabolic pathways; Peroxisome; AMPK signaling pathway; Alcoholic liver disease","","",494.7,480.7,515.7,450,466.9,891.2,0.8246778386151209,-0.2780974560186871,0.5056815000528305,0.2961229343878942,0.6531235348800386,0.1850046664392493,5659]
["O95825-1","Quinone oxidoreductase-like protein 1 [OS=Homo sapiens]",11,2,3,2,349,38.7,5.78,10.21,"other metabolic processes","","other molecular function","CRYZL1","ENSG00000205758","","","",262.7,233.8,253.5,236.9,234,141.4,1.224889759921607,0.2926519125167303,0.23070738609624603,0.6369385013198515,0.4767430831149172,0.3217155992506301,3537]
["O95831-1","Apoptosis-inducing factor 1, mitochondrial [OS=Homo sapiens]",47,23,87,23,613,66.9,8.95,288.87,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","AIFM1","ENSG00000156709","Apoptosis; Necroptosis","","Apoptosis modulation and signaling; Nanomaterial induced apoptosis; Apoptosis modulation by HSP70",9782.1,9744.6,9778,9088.5,8936.1,7357.7,1.1545328831508572,0.20730926421906257,0.07744697058568208,1.1109955654277315,0.28574452701198905,0.5440220790823056,1981]
["O95834-3","Isoform 3 of Echinoderm microtubule-associated protein-like 2 [OS=Homo sapiens]",14,12,29,12,850,92,7.06,75.05,"","","","EML2","","","","",3466.3,3428.3,3475.3,3489,3410.4,3541.9,0.9931617710438357,-0.009899364773068757,0.5912085513379806,0.22825929286079627,0.712237234502934,0.14737532592087152,6067]
["O95835","Serine/threonine-protein kinase LATS1 [OS=Homo sapiens]",1,1,1,1,1130,126.8,8.7,3.38,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","LATS1","ENSG00000131023","Hippo signaling pathway; Hippo signaling pathway","Signaling by Hippo","Mesodermal commitment pathway; Transcription co-factors SKI and SKIL protein partners; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Overview of leukocyte-intrinsic Hippo pathway functions; Malignant pleural mesothelioma",26.2,31.2,23.5,27.8,21.3,48.6,0.8280450358239508,-0.27221885953840774,0.5476476812393543,0.26149874680968344,0.6834141885228684,0.16531600895367052,5857]
["O95841","Angiopoietin-related protein 1 [OS=Homo sapiens]",2,1,1,1,491,56.7,8.21,0,"developmental processes;signal transduction","non-structural extracellular;extracellular matrix","signal transduction activity or receptor binding","ANGPTL1","ENSG00000116194","","","RAC1/PAK1/p38/MMP2 pathway",53.1,60.7,58.7,54.7,48.9,58,1.067450495049505,0.09416916380109902,0.35781671019896344,0.4463393815502481,0.5588210117188512,0.2527272727403992,4680]
["O95848","uridine diphosphate glucose pyrophosphatase [OS=Homo sapiens]",7,1,1,1,222,24.1,5.05,3.49,"protein metabolism;other metabolic processes","cytosol","other molecular function","NUDT14","ENSG00000183828","","Synthesis of dolichyl-phosphate-glucose","",35.9,39,36.7,42,36.2,57.5,0.8224023581429626,-0.2820836935896663,0.27935203791311364,0.5538481560518335,0.5137856177923874,0.2892180569416568,3974]
["O95861-1","3'(2'),5'-bisphosphate nucleotidase 1 [OS=Homo sapiens]",60,14,59,13,308,33.4,5.69,154.82,"other metabolic processes;developmental processes","cytosol","other molecular function","BPNT1; HEL20","ENSG00000162813; ENSPTRG00000001996","Sulfur metabolism; Metabolic pathways","Cytosolic sulfonation of small molecules","",6440.7,6146.5,6402.8,5863,5608.1,4592.2,1.1821979294416465,0.24147159889812198,0.07082414194214771,1.149818678396622,0.27173420128879666,0.5658556965242871,1905]
["O95865","N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 [OS=Homo sapiens]",53,12,36,11,285,29.6,6.01,135.24,"other metabolic processes;signal transduction;other biological processes","cytosol;mitochondrion","other molecular function","DDAH2","ENSG00000206395; ENSG00000213722; ENSG00000225635; ENSG00000226634; ENSG00000227317; ENSG00000228128; ENSG00000233076","","eNOS activation","Nitric oxide metabolism in cystic fibrosis",3594.7,3510.4,3628.5,3466.9,3500.3,5286.7,0.8759333763128473,-0.19110695259325802,0.4473771442678042,0.34932620703403006,0.6130257869241434,0.21252125650391443,5334]
["O95870-1","Protein ABHD16A [OS=Homo sapiens]",26,11,30,11,558,63.2,8.13,82.31,"other metabolic processes","other membranes","other molecular function","ABHD16A","ENSG00000204427; ENSG00000206403; ENSG00000224552; ENSG00000230475; ENSG00000231488; ENSG00000235676; ENSG00000236063; ENSGGOG00000009970","","","IL-18 signaling pathway",1919.2,1919.3,2023.2,1722.3,1820.7,2555.7,0.961139259186384,-0.05718261708073854,0.7806296838183032,0.1075549384847154,0.8518397072302146,0.06964211980459054,6698]
["O95873","Uncharacterized protein C6orf47 [OS=Homo sapiens]",10,3,5,3,294,31.7,6.37,5.67,"","","","C6orf47","ENSG00000203623; ENSG00000204439; ENSG00000226103; ENSG00000226531; ENSG00000228177; ENSG00000228435; ENSG00000235360","","","",473,492.1,515.4,644.5,723.6,993.3,0.6269585838909123,-0.6735579513635295,0.05071785556530846,1.2948391174260447,0.23110773461773038,0.6361855194902165,1604]
["O95881","Thioredoxin domain-containing protein 12 [OS=Homo sapiens]",30,5,11,5,172,19.2,5.4,26.41,"other biological processes","ER/Golgi","other molecular function","TXNDC12","ENSG00000117862","Glutathione metabolism; Metabolic pathways","","",1578.5,1928.4,1515.2,1593.5,1638,1454.6,1.0717014148225603,0.09990301460451267,0.46810427629769125,0.32965739142114303,0.6268549203847243,0.20283296087104777,5458]
["O95900","Mitochondrial mRNA pseudouridine synthase TRUB2 [OS=Homo sapiens]",12,4,9,3,331,36.7,8.98,19.47,"RNA metabolism OR transcription;other metabolic processes;other biological processes","mitochondrion;other cell component","other molecular function","TRUB2","ENSG00000167112","","","",239.3,259.9,248.8,292.1,270.8,240.2,0.9313908604158883,-0.1025413695869352,0.3201340402727056,0.4946681442982418,0.5411331406922306,0.26669586769554154,4324]
["O95905","Protein ecdysoneless homolog [OS=Homo sapiens]",15,6,10,6,644,72.7,4.87,14.3,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","ECD","ENSG00000122882","","","",465.2,538.9,524.8,683.1,740.1,818.3,0.6820878875752844,-0.5519704512393068,6.2907450649552525E-3,2.2012979144218243,0.08594216014908027,1.0657937345590798,535]
["O95983-1","methyl-CpG-binding domain protein 3 [OS=Homo sapiens]",6,2,3,2,291,32.8,5.34,7.15,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MBD3","ENSG00000071655; ENSPTRG00000010209","","Potential therapeutics for SARS; HDACs deacetylate histones; Regulation of PTEN gene transcription; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation","Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome",348.6,402.2,333.3,424.9,477.5,172.1,1.0089343880874824,0.012832357736051556,0.9751483797425711,0.010929296506074304,0.9848500079505944,0.006629907248154884,7237]
["O95985","DNA topoisomerase 3-beta-1 [OS=Homo sapiens]",14,8,10,8,862,96.6,8.12,22.94,"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TOP3B","ENSG00000100038","Homologous recombination; Fanconi anemia pathway","","",454.8,483.5,491,477.9,512.6,783.3,0.8057841921298906,-0.31153459190707544,0.3027340715973508,0.5189386980589272,0.5278347636700946,0.2775020101506246,4192]
["O95989","Diphosphoinositol polyphosphate phosphohydrolase 1 [OS=Homo sapiens]",33,5,11,5,172,19.5,6.34,27.02,"cell-cell signaling;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","NUDT3","ENSG00000272325","","Synthesis of pyrophosphates in the cytosol","",1080.6,1118.1,1061.5,1091.1,987.9,1159,1.0068560840024707,0.009857484999202295,0.8946134854961989,0.04836455951408547,0.932904831715183,0.030162657613656847,7009]
["O95997","Securin [OS=Homo sapiens]",11,2,2,2,202,22,6.6,5.51,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PTTG1","ENSG00000164611","Cell cycle; Oocyte meiosis; Human T-cell leukemia virus 1 infection","APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids","Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition",122,148.1,124.8,109.4,116.7,138.3,1.0836992316136114,0.11596440865829781,0.4441807115225767,0.352440304547538,0.6124347897601421,0.21294014688999152,5301]
["O95999","B-cell lymphoma/leukemia 10 [OS=Homo sapiens]",3,1,1,1,233,26.2,5.74,2.09,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","BCL10","ENSG00000142867","NF-kappa B signaling pathway; C-type lectin receptor signaling pathway; T cell receptor signaling pathway; B cell receptor signaling pathway; Shigellosis; Tuberculosis","E3 ubiquitin ligases ubiquitinate target proteins; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling","B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Modulators of TCR signaling and T cell activation; T-cell receptor (TCR) signaling pathway",60.6,59.8,46.3,71.9,47.3,372.4,0.33909682668836455,-1.5602308113862446,0.3590274399924921,0.444872357600206,0.5589204598306975,0.25264999231836277,4695]
["O96000","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [OS=Homo sapiens]",26,4,6,4,172,20.8,8.48,9.51,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity","NDUFB10","ENSG00000140990","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Modulators of TCR signaling and T cell activation; Oxidative phosphorylation",257.9,342.1,246.2,345.3,311.7,298.7,0.8854242963272994,-0.17555913289276223,0.33388062196741464,0.4764087861473002,0.5470373158394606,0.2619830475049439,4461]
["O96005-1","Cleft lip and palate transmembrane protein 1 [OS=Homo sapiens]",33,14,54,14,669,76,6.3,171.56,"developmental processes;other biological processes","plasma membrane;other membranes;other cell component","","CLPTM1","ENSG00000104853","","","",3664,3607.5,3816.1,3384.4,3465.6,5415.3,0.9039811500737855,-0.1456354051878311,0.5876606448936705,0.23087339262371406,0.7106571233500725,0.14833988640672885,6044]
["O96006","zinc finger BED domain-containing protein 1 [OS=Homo sapiens]",1,1,1,1,694,78.1,6.1,2.51,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBED1","ENSG00000214717","","SUMOylation of chromatin organization proteins","",34.2,38.4,39.9,52.4,46.8,30.5,0.8673862760215884,-0.20525347814729994,0.4457888695256445,0.35087077920243787,0.6125720713222289,0.21284280763904517,5319]
["O96007","molybdopterin synthase catalytic subunit [OS=Homo sapiens]",20,4,5,4,188,20.9,5.44,12.16,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","MOCS2","ENSG00000164172","Folate biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Sulfur relay system","Molybdenum cofactor biosynthesis","",417.4,416,441.7,500.4,472.2,245.9,1.0464505539597866,0.06550414413798318,0.8272068335309237,0.08238588654158129,0.8826357293835797,0.05421849615003393,6850]
["O96008","Mitochondrial import receptor subunit TOM40 homolog [OS=Homo sapiens]",50,14,97,14,361,37.9,7.25,383.07,"cell organization and biogenesis;transport","other membranes;cytosol;mitochondrion;other cell component","transporter activity","TOMM40","ENSG00000130204","Amyotrophic lateral sclerosis; Pathways of neurodegeneration","Mitochondrial protein import; PINK1-PRKN Mediated Mitophagy","IL-18 signaling pathway",6273.9,6419,6670.9,5441.5,5074.6,5515.4,1.2078595265570906,0.27245267972619397,3.4281240532240812E-3,2.4649434706882,0.06441171903602778,1.1910351101299346,389]
["O96011-1","Peroxisomal membrane protein 11B [OS=Homo sapiens]",31,8,22,8,259,28.4,9.85,65.56,"cell organization and biogenesis;signal transduction","other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PEX11B","ENSG00000131779; ENSPPAG00000024465; ENSPTRG00000001203","Peroxisome","Class I peroxisomal membrane protein import","",2497,2505.1,2720.8,2543.1,2369.1,3112.4,0.9624031104354112,-0.05528678965257995,0.6920894738825941,0.15983775597448605,0.7835319028203036,0.10594331580452712,6456]
["O96013-1","serine/threonine-protein kinase PAK 4 [OS=Homo sapiens]",2,1,1,1,591,64,9.73,4.48,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;ER/Golgi;other cell component","kinase activity;other molecular function","PAK4","ENSG00000130669","ErbB signaling pathway; Ras signaling pathway; Axon guidance; Focal adhesion; T cell receptor signaling pathway; Regulation of actin cytoskeleton; Human immunodeficiency virus 1 infection; MicroRNAs in cancer; Renal cell carcinoma","CDC42 GTPase cycle; RAC3 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; Activation of RAC1; RHOH GTPase cycle","Integrin-mediated cell adhesion; Focal adhesion; Ras signaling; Pancreatic adenocarcinoma pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; 22q11.2 copy number variation syndrome; Malignant pleural mesothelioma; Regulation of actin cytoskeleton; ErbB signaling pathway",106.8,122.5,132.8,151.7,172,269.7,0.6102123356926189,-0.7126167500040892,0.10692140302372886,0.9709353510615384,0.3358352104428166,0.47387377246429535,2327]
["O96017-1","Serine/threonine-protein kinase Chk2 [OS=Homo sapiens]",25,10,20,10,543,60.9,5.91,64.49,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","CHEK2","ENSG00000183765","Cell cycle; p53 signaling pathway; Cellular senescence; Human T-cell leukemia virus 1 infection","Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Regulation of TP53 Activity through Methylation; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Stabilization of p53","miRNA regulation of DNA damage response; Cell cycle; ATM signaling in development and disease ; miRNA regulation of p53 pathway in prostate cancer; DNA damage response",1252.4,1300.8,1240.8,1221.8,1123,1203.8,1.0691540325762272,0.09646971650589804,0.08258541838213743,1.0830966267136022,0.2938738183812281,0.5318391040908886,2054]
["O96018","amyloid-beta A4 precursor protein-binding family A member 3 [OS=Homo sapiens]",14,5,7,5,575,61.4,4.94,15.3,"cell-cell signaling;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","enzyme regulator activity;other molecular function","APBA3","ENSG00000011132","","Neurexins and neuroligins","",564.6,549.7,551.1,629.5,584.2,574.5,0.9313275919919471,-0.10263937370707672,0.08065774208117675,1.0933539397225334,0.29012177011383905,0.537419681450442,2032]
["O96019-1","Actin-like protein 6A [OS=Homo sapiens]",37,12,55,12,429,47.4,5.6,163.76,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;nucleus","other molecular function","ACTL6A","ENSCANG00000034249; ENSCATG00000017467; ENSCCAG00000029449; ENSCJAG00000013036; ENSCSAG00000013017; ENSG00000136518; ENSGGOG00000015710; ENSMFAG00000030153; ENSMMUG00000009742; ENSPANG00000024431; ENSPPAG00000031814; ENSPTRG00000023973; ENSRBIG00000036584; ENSRROG00000035215","Thermogenesis; Hepatocellular carcinoma","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines; UCH proteinases; HATs acetylate histones; DNA Damage Recognition in GG-NER","Gastric cancer network 1; Tumor suppressor activity of SMARCB1; Thermogenesis",7982.7,8284.7,8038.4,9685.1,10079.6,8348.3,0.8645751076014656,-0.20993679538370794,0.07555075640030884,1.1217611832265337,0.2811611397809864,0.5510447047934917,1964]
["O96028-1","Histone-lysine N-methyltransferase NSD2 [OS=Homo sapiens]",13,14,20,14,1365,152.2,8.69,51.59,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NSD2","ENSG00000109685","Lysine degradation; Metabolic pathways; Transcriptional misregulation in cancer","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; PKMTs methylate histone lysines; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)","",1191.6,1185.3,1165.6,1394.4,1516.1,1245.2,0.8524436316384724,-0.23032365669697472,0.060280998968052404,1.2198195592320256,0.2509076431990291,0.6004861089181364,1756]
["P00156","cytochrome b [OS=Homo sapiens]",2,1,1,1,380,42.7,8.05,2.39,"other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MT-CYB","ENSG00000198727","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly",218.8,246.5,239.4,164.5,181.3,105.5,1.5614890316862398,0.6429224355208658,0.025907499113427285,1.5865745080353677,0.1668351638943084,0.7777124076805363,1135]
["P00167-1","Cytochrome b5 [OS=Homo sapiens]",49,5,12,5,134,15.3,4.96,47.76,"other metabolic processes;transport;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cell component","transporter activity;other molecular function","CYB5A","ENSG00000166347; ENSPTRG00000010111","","Vitamin C (ascorbate) metabolism","Oxidation by cytochrome P450",1651.2,2051.8,1631.3,2164.5,2172.5,1578.4,0.9017648848767624,-0.14917676300076396,0.4643571494794258,0.33314786344520386,0.6235506899770573,0.2051282358783047,5443]
["P00338-1","L-lactate dehydrogenase A chain [OS=Homo sapiens]",66,23,487,21,332,36.7,8.27,1452.1,"other metabolic processes;stress response;developmental processes;other biological processes","cytosol;other cell component","other molecular function","HEL-S-133P; LDHA","ENSG00000134333; ENSG00000288299","Glycolysis / Gluconeogenesis; Cysteine and methionine metabolism; Pyruvate metabolism; Propanoate metabolism; Metabolic pathways; HIF-1 signaling pathway; Glucagon signaling pathway; Central carbon metabolism in cancer","Pyruvate metabolism","Cori cycle; HIF1A and PPARG regulation of glycolysis; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling pathway; Amino acid metabolism; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - VitD3 signaling; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Orexin receptor pathway; CCL18 signaling pathway; Glycolysis and gluconeogenesis",54702.2,52934.7,56745.8,51375.8,45637.8,33748.3,1.2571146488388438,0.33011622952661845,0.10226280429997071,0.990282302013316,0.3298494424662339,0.48168424565672147,2266]
["P00367","Glutamate dehydrogenase 1, mitochondrial [OS=Homo sapiens]",47,24,162,24,558,61.4,7.8,471.84,"other metabolic processes;other biological processes","mitochondrion;ER/Golgi;other cell component","other molecular function","GLUD1","ENSG00000148672","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Nitrogen metabolism; Metabolic pathways; Carbon metabolism; Necroptosis; Proximal tubule bicarbonate reclamation","Transcriptional activation of mitochondrial biogenesis; Glutamate and glutamine metabolism","VEGFA-VEGFR2 signaling pathway; Amino acid metabolism; Metabolic reprogramming in colon cancer; 22q11.2 copy number variation syndrome; Amino acid metabolism pathway excerpt: histidine catabolism extension",17590.5,16934.1,17986.7,15392.9,15169.1,18358.2,1.0734073041402121,0.10219761026386982,0.32694185657610325,0.48552947551518527,0.5437128622786663,0.26463039304100305,4395]
["P00374","dihydrofolate reductase [OS=Homo sapiens]",41,7,22,7,187,21.4,7.42,58.4,"cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;mitochondrion","nucleic acid binding activity;other molecular function","DHFR","ENSG00000228716","One carbon pool by folate; Folate biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Antifolate resistance","G1/S-Specific Transcription; Metabolism of folate and pterines; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation","Fluoropyrimidine activity; Folate metabolism; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration and one-carbon metabolism; Ethanol effects on histone modifications; Nucleotide metabolism",2458.3,2468.9,2361.7,2935.6,2891.6,1746.5,0.9623961868043363,-0.055297168592587966,0.8199846410868433,0.08619428219396782,0.8777486440690887,0.05662983275269088,6828]
["P00387","NADH-cytochrome b5 reductase 3 [OS=Homo sapiens]",45,12,80,12,301,34.2,7.59,261.81,"other metabolic processes;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CYB5R3","ENSG00000100243","Amino sugar and nucleotide sugar metabolism","Neutrophil degranulation; Phase I - Functionalization of compounds; Vitamin C (ascorbate) metabolism","Oxidation by cytochrome P450",7746.2,7634.3,8584.6,7180,7109.5,8334.2,1.0592918046119775,0.08310006532326869,0.41961276119723606,0.3771513125822256,0.5937947089236396,0.22636367655389197,5165]
["P00390","Glutathione reductase, mitochondrial [OS=Homo sapiens]",47,18,83,18,522,56.2,8.5,280.8,"other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion","other molecular function","GSR","ENSG00000104687","Glutathione metabolism; Metabolic pathways; Thyroid hormone synthesis; Diabetic cardiomyopathy","","Glutathione metabolism; Selenium micronutrient network; Nuclear receptors meta-pathway; NRF2 pathway; Amino acid metabolism; One-carbon metabolism and related pathways; Oxidative stress response; Vitamin D-sensitive calcium signaling in depression; Sulfation biotransformation reaction; Metapathway biotransformation Phase I and II",9508.4,9502.5,9455.3,9536.3,8739.1,9030.8,1.0424811947469805,0.06002135921912571,0.17304209938406487,0.7618482245826961,0.41494904999938653,0.382005225366286,3048]
["P00395","Cytochrome c oxidase subunit 1 [OS=Homo sapiens]",2,1,2,1,513,57,6.7,6.58,"other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MT-CO1","ENSG00000198804","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Electron transport chain: OXPHOS system in mitochondria; Effects of nitric oxide; Nonalcoholic fatty liver disease; Neuroinflammation; Mitochondrial complex IV assembly",291,279.3,337.6,362,315,707.4,0.6558075700664547,-0.6086555398561442,0.2726815687745866,0.56434421611048,0.5081666461431549,0.29399384355827235,3922]
["P00403","Cytochrome c oxidase subunit 2 [OS=Homo sapiens]",31,6,33,6,227,25.5,4.82,81.38,"other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MT-CO2","ENSG00000198712","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Cytoprotection by HMOX1; Respiratory electron transport; TP53 Regulates Metabolic Genes","Electron transport chain: OXPHOS system in mitochondria; Endothelin pathways; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Neuroinflammation; Mitochondrial complex IV assembly; CCL18 signaling pathway",4666.6,4637.4,5083.8,4048.8,4186.1,5395.3,1.0555824566037182,0.078039278909507,0.6057269132320062,0.21772312964116552,0.7221102607751971,0.1413964838844268,6131]
["P00439","phenylalanine-4-hydroxylase [OS=Homo sapiens]",2,1,1,1,452,51.8,6.6,0,"other metabolic processes","cytosol","other molecular function","PAH","ENSG00000171759","Phenylalanine metabolism; Phenylalanine, tyrosine and tryptophan biosynthesis; Folate biosynthesis; Metabolic pathways; Biosynthesis of amino acids","Phenylketonuria; Phenylalanine metabolism","Biogenic amine synthesis; Sudden infant death syndrome (SIDS) susceptibility pathways",37.4,45.6,81.1,53,42.1,26.4,1.3506172839506172,0.4336189250205694,0.41071939135877217,0.3864547922490892,0.5871206789441161,0.23127262309165322,5113]
["P00441","Superoxide dismutase [Cu-Zn] [OS=Homo sapiens]",97,16,152,16,154,15.9,6.13,551.15,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","SOD1","ENSG00000142168","Peroxisome; Longevity regulating pathway; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Platelet degranulation ; Detoxification of Reactive Oxygen Species","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; AGE/RAGE pathway; Dopamine metabolism; Amyotrophic lateral sclerosis (ALS); Copper homeostasis; Physico-chemical features and toxicity-associated pathways; One-carbon metabolism and related pathways; Oxidative stress response; Extracellular vesicles in the crosstalk of cardiac cells",17838.2,17901.8,18350,18055.1,17869.9,29445.5,0.8274374526736066,-0.2732778344818175,0.3819602979074759,0.4179817766060541,0.568584076864713,0.24520530684504968,4910]
["P00450","Ceruloplasmin [OS=Homo sapiens]",1,1,1,1,1065,122.1,5.72,2.11,"transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi","other molecular function","CP","ENSG00000047457","Porphyrin and chlorophyll metabolism; Ferroptosis","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Metal ion SLC transporters; Iron uptake and transport; Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages); Defective CP causes aceruloplasminemia (ACERULOP)","Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway",53.3,43.6,57.1,39.3,43,64.3,{"$f":"AVERAGE(S898:U898)/AVERAGE(V898:X898)","v":1.0504774897680764},{"$f":"LOG(Y898,2)","v":0.07104524744845188},{"$f":"TTEST(V898:X898,S898:U898,2,2)","v":0.7923671254428298},0.10107355122403122,{"$f":"AA898*7309/AE898","v":0.8602809447209809},0.06535969664384447,6732]
["P00488","Coagulation factor XIII A chain [OS=Homo sapiens]",1,1,2,1,732,83.2,6.09,2.76,"protein metabolism;other metabolic processes;stress response","non-structural extracellular;other cell component","other molecular function","F13A1","ENSG00000124491","Complement and coagulation cascades; Coronavirus disease","Platelet degranulation ; Interleukin-4 and Interleukin-13 signaling; Common Pathway of Fibrin Clot Formation","Complement system",75.9,79.1,70.4,66.3,70.2,52.8,1.190702588483888,0.25181310446851585,0.10890613055753434,{"$f":"-LOG10(AA899)","v":0.9629476721967615},0.33757205608355323,{"$f":"-LOG10(AC899)","v":0.4716335110718589},2358]
["P00491","purine nucleoside phosphorylase [OS=Homo sapiens]",66,15,60,15,289,32.1,6.95,220.04,"other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","PNP","ENSG00000198805","Purine metabolism; Pyrimidine metabolism; Nicotinate and nicotinamide metabolism; Metabolic pathways","Neutrophil degranulation; Purine catabolism; Purine salvage","VEGFA-VEGFR2 signaling pathway",6426.7,6726.9,6495.7,5834.4,5076.4,5116.8,1.2259664578601912,0.2939195077882859,0.010026906387093096,1.9988330396869713,0.1052969235391716,0.9775843174135606,696]
["P00492","Hypoxanthine-guanine phosphoribosyltransferase [OS=Homo sapiens]",62,10,57,10,218,24.6,6.68,199.36,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","other molecular function","HPRT1","ENSG00000165704","Purine metabolism; Drug metabolism; Metabolic pathways","Purine salvage","Mesodermal commitment pathway; Nucleotide metabolism",6585.7,6407.3,6685.8,6218.4,6605.2,3693.7,1.1914053749704854,0.25266437286104054,0.31428499582807096,0.5026763519910625,0.5365823486352186,0.27036361794139896,4281]
["P00505","Aspartate aminotransferase, mitochondrial [OS=Homo sapiens]",51,22,164,22,430,47.5,9.01,475.51,"other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;other cell component","other molecular function","GOT2","ENSG00000125166","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Cysteine and methionine metabolism; Arginine and proline metabolism; Tyrosine metabolism; Phenylalanine metabolism; Phenylalanine, tyrosine and tryptophan biosynthesis; Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids; Fat digestion and absorption","Gluconeogenesis; Glyoxylate metabolism and glycine degradation; Aspartate and asparagine metabolism; Glutamate and glutamine metabolism; Degradation of cysteine and homocysteine","Alanine and aspartate metabolism; Amino acid metabolism; Metabolic reprogramming in colon cancer; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis and gluconeogenesis",24794.7,24282.1,25259.7,21795,20893.5,16135.4,1.2637125386110066,0.33766832563082155,0.043771437229996116,1.3588091931445059,0.21748839885386922,0.6625639039880631,1471]
["P00519","Tyrosine-protein kinase ABL1 [OS=Homo sapiens]",1,1,1,1,1130,122.8,8.66,0,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;kinase activity;other molecular function","ABL1","ENSG00000097007","ErbB signaling pathway; Ras signaling pathway; Cell cycle; Axon guidance; Neurotrophin signaling pathway; Pathogenic Escherichia coli infection; Pathways in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chronic myeloid leukemia; Viral myocarditis","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Factors involved in megakaryocyte development and platelet production; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RHO GTPases Activate WASPs and WAVEs; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Myogenesis; Cyclin D associated events in G1; RUNX2 regulates osteoblast differentiation; HDR through Single Strand Annealing (SSA); Role of ABL in ROBO-SLIT signaling","miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; TP53 network; Cell cycle; Integrated breast cancer pathway; Microtubule cytoskeleton regulation; Pathogenic Escherichia coli infection; Retinoblastoma gene in cancer; ATM signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Imatinib and chronic myeloid leukemia; VEGFA-VEGFR2 signaling pathway; Ras signaling; Acute viral myocarditis; EGF/EGFR signaling pathway; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)",29.2,28.3,19.9,32.6,41,44.8,0.6537162162162163,-0.6132636094845393,0.04282694212669161,1.3682829334230373,0.21572854583321086,0.6660923839768002,1451]
["P00558","phosphoglycerate kinase 1 [OS=Homo sapiens]",76,29,692,24,417,44.6,8.1,2197.3,"protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;other membranes;cytosol","kinase activity;other molecular function","PGK1","ENSG00000102144","Glycolysis / Gluconeogenesis; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; HIF-1 signaling pathway","Glycolysis; Gluconeogenesis; Manipulation of host energy metabolism","Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Glycolysis and gluconeogenesis",102590.8,99172.1,102160.2,96243.4,92534.9,93015.5,1.0785301167023549,0.10906646264625307,9.627741436286176E-3,2.0164755817021587,0.10257895358282167,0.9889417355249374,686]
["P00568","Adenylate kinase isoenzyme 1 [OS=Homo sapiens]",39,6,16,6,194,21.6,8.63,37.83,"other metabolic processes","cytosol;cytoskeleton;other cell component","kinase activity;other molecular function","AK1","ENSG00000106992","Purine metabolism; Thiamine metabolism; Metabolic pathways; Biosynthesis of cofactors","Interconversion of nucleotide di- and triphosphates","",1235.8,1123.5,1275.2,1145.7,1171.7,983.2,1.1011634248318487,0.13902859669338086,0.2092797728966297,0.6792727446373351,0.4547044768434799,0.34227076987923666,3364]
["P00734","Prothrombin [OS=Homo sapiens]",6,3,3,3,622,70,5.9,10.7,"protein metabolism;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi","signal transduction activity or receptor binding;other molecular function","F2","ENSG00000180210","Phospholipase D signaling pathway; Neuroactive ligand-receptor interaction; Complement and coagulation cascades; Platelet activation; Regulation of actin cytoskeleton; Pathogenic Escherichia coli infection; Coronavirus disease; Pathways in cancer","Cell surface interactions at the vascular wall; Regulation of Complement cascade; G alpha (q) signalling events; Peptide ligand-binding receptors; Thrombin signalling through proteinase activated receptors (PARs); Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Intrinsic Pathway of Fibrin Clot Formation; Common Pathway of Fibrin Clot Formation; Defective F8 cleavage by thrombin; Gamma-carboxylation of protein precursors; Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus; Removal of aminoterminal propeptides from gamma-carboxylated proteins; Platelet Aggregation (Plug Formation); Defective factor XII causes hereditary angioedema","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Blood clotting cascade; IL1 and megakaryocytes in obesity; Regulation of actin cytoskeleton; Complement and coagulation cascades",219.4,218.3,231.9,230,200.1,159.6,1.135492623367814,0.18331833372842798,0.27077691031515055,0.5673883715609286,0.507203597512413,0.2948176747354549,3902]
["P00747","Plasminogen [OS=Homo sapiens]",4,3,9,3,810,90.5,7.24,19.13,"cell organization and biogenesis;protein metabolism;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","PLG","ENSG00000122194","Neuroactive ligand-receptor interaction; Complement and coagulation cascades; Staphylococcus aureus infection; Influenza A","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Signaling by PDGF; Platelet degranulation ; Activation of Matrix Metalloproteinases; Dissolution of Fibrin Clot","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Blood clotting cascade; Complement system; Fibrin complement receptor 3 signaling pathway; Complement and coagulation cascades",1366.5,1334.7,1389.5,1165.8,1215.3,1320,1.1052660019994054,0.14439362172746126,0.054258599586984514,1.2655314195588245,0.2396230237953292,0.6204714557865891,1655]
["P00813","adenosine deaminase [OS=Homo sapiens]",69,19,119,19,363,40.7,5.95,352.3,"cell adhesion;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","ADA","ENSG00000196839","Purine metabolism; Metabolic pathways; Primary immunodeficiency","Purine salvage","",10690.6,10497.5,10790,10040.6,9749.2,8942.4,1.1129708132339324,0.15441575965671028,0.03331152223174411,1.4774055209641401,0.1897692252469351,0.7217742154550957,1283]
["P00846","ATP synthase subunit A [OS=Homo sapiens]",4,1,5,1,226,24.8,10.1,16.69,"other metabolic processes;stress response;transport;other biological processes","other membranes;mitochondrion","transporter activity","MT-ATP6","ENSG00000198899","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation",781.1,891.4,795.9,723.5,859.9,969,0.9670897978373296,-0.04827823943573831,0.7408523168432084,0.13026835662572456,0.8205621433258085,0.0858885231038742,6599]
["P00918","Carbonic anhydrase 2 [OS=Homo sapiens]",26,5,6,5,260,29.2,7.4,18.9,"other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","CA2","ENSG00000104267","Nitrogen metabolism; Metabolic pathways; Proximal tubule bicarbonate reclamation; Collecting duct acid secretion; Gastric acid secretion; Pancreatic secretion; Bile secretion","Reversible hydration of carbon dioxide; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide","Proximal tubule transport",313.5,270.3,304.2,295.9,269.3,1146.1,0.5189037573774324,-0.9464611124310848,0.39495342074782436,0.40345412033560335,0.5766509293339689,0.23908700372383482,5006]
["P00966","Argininosuccinate synthase [OS=Homo sapiens]",5,3,3,3,412,46.5,8.02,6.49,"other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","ASS1","ENSG00000130707","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Metabolic pathways; Biosynthesis of amino acids; Fluid shear stress and atherosclerosis","Urea cycle","Alanine and aspartate metabolism; Amino acid metabolism",445.1,440.8,428.2,416.4,386.2,712.9,0.8671065654899374,-0.20571878649650446,0.5550448344900416,0.2556719347418467,0.6884138291681171,0.1621504139530229,5893]
["P00973-1","2'-5'-oligoadenylate synthase 1 [OS=Homo sapiens]",18,6,13,6,400,46,8.22,35.48,"cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component","nucleic acid binding activity;other molecular function","OAS1","ENSG00000089127","NOD-like receptor signaling pathway; Hepatitis C; Measles; Influenza A; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease","OAS antiviral response; Interferon gamma signaling; Interferon alpha/beta signaling","Immune response to tuberculosis; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; Type II interferon signaling (IFNG)",824.8,847.5,872.9,941.5,876.9,728.7,0.9992540536296178,-1.0765747127582247E-3,0.992636288637449,0.003209851980805609,0.9948140180517092,2.2581036598307955E-3,7293]
["P01008","Antithrombin-III [OS=Homo sapiens]",2,1,2,1,464,52.6,6.71,2.3,"stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi","enzyme regulator activity;other molecular function","SERPINC1","ENSG00000117601","Complement and coagulation cascades","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Intrinsic Pathway of Fibrin Clot Formation; Common Pathway of Fibrin Clot Formation","Complement and coagulation cascades",242.9,224.5,242.4,228.8,251,486.2,0.7347826086956522,-0.444610614662191,0.3594466606316533,0.4443655467609806,0.5592157604420507,0.2524205973185947,4698]
["P01023","alpha-2-macroglobulin [OS=Homo sapiens]",1,2,4,2,1474,163.2,6.46,8.32,"other biological processes","non-structural extracellular;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","A2M","ENSG00000175899","Complement and coagulation cascades","Platelet degranulation ; Intrinsic Pathway of Fibrin Clot Formation; Degradation of the extracellular matrix; HDL assembly","Complement system; Complement and coagulation cascades",725.4,949.2,971,855.8,697,913.6,1.0726565034057736,0.10118815608393958,0.5886997841645794,0.23010612341349665,0.7110901871523567,0.14807531446195155,6051]
["P01024","Complement C3 [OS=Homo sapiens]",1,1,1,1,1663,187,6.4,3.6,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity","C3","ENSG00000125730","Neuroactive ligand-receptor interaction; Phagosome; Complement and coagulation cascades; Neutrophil extracellular trap formation; Alcoholic liver disease; Shigellosis; Pertussis; Legionellosis; Leishmaniasis; Chagas disease; Staphylococcus aureus infection; Tuberculosis; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Coronavirus disease; Viral carcinogenesis; Systemic lupus erythematosus","Purinergic signaling in leishmaniasis infection; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; G alpha (i) signalling events; Neutrophil degranulation; Peptide ligand-binding receptors; Alternative complement activation; Activation of C3 and C5","Allograft Rejection; Complement system; TYROBP causal network in microglia; Cells and molecules involved in local acute inflammatory response ; 16p11.2 distal deletion syndrome; Complement system in neuronal development and plasticity; Acquired partial lipodystrophy / Barraquer-Simons syndrome; Complement activation; Complement and coagulation cascades",86,80.7,90,75.1,71,60.7,1.2412959381044486,0.31184711026048356,0.03029196832728181,1.518672505937413,0.18118166653363563,0.7418857499599757,1222]
["P01111","GTPase NRas [OS=Homo sapiens]",61,8,33,4,189,21.2,5.17,92.25,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi","other molecular function","NRAS","ENSG00000213281","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; Chemokine signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Mitophagy; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Apelin signaling pathway; Gap junction; Signaling pathways regulating pluripotency of stem cells; C-type lectin receptor signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Thermogenesis; Long-term potentiation; Neurotrophin signaling pathway; Cholinergic synapse; Serotonergic synapse; Long-term depression; Regulation of actin cytoskeleton; Insulin signaling pathway; GnRH signaling pathway; Estrogen signaling pathway; Melanogenesis; Prolactin signaling pathway; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Relaxin signaling pathway; GnRH secretion; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Alzheimer disease; Pathways of neurodegeneration; Alcoholism; Hepatitis C; Hepatitis B; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Endometrial cancer; Glioma; Prostate cancer; Thyroid cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis","Neutrophil degranulation; Tie2 Signaling; FCERI mediated MAPK activation; Regulation of RAS by GAPs; Signaling by BRAF and RAF1 fusions; Signaling by SCF-KIT; Downstream signal transduction; DAP12 signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; GRB2 events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; GRB2 events in EGFR signaling; SHC1 events in EGFR signaling; NCAM signaling for neurite out-growth; Signaling by FGFR1 in disease; p38MAPK events; SHC-mediated cascade:FGFR1; FRS-mediated FGFR1 signaling; SHC-mediated cascade:FGFR2; FRS-mediated FGFR2 signaling; Signaling by FGFR2 in disease; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ; SHC-mediated cascade:FGFR3; FRS-mediated FGFR3 signaling; FRS-mediated FGFR4 signaling; SHC-mediated cascade:FGFR4; Signaling by FGFR3 point mutants in cancer; FLT3 Signaling; Activated NTRK2 signals through FRS2 and FRS3; RAS processing; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; CD209 (DC-SIGN) signaling; Activation of RAS in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; SOS-mediated signalling; SHC-related events triggered by IGF1R; Signaling by FGFR4 in disease; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants; RAS signaling downstream of NF1 loss-of-function variants; Insulin receptor signalling cascade; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; MET activates RAS signaling; Signaling by FGFR3 fusions in cancer; Activated NTRK2 signals through RAS; Activated NTRK3 signals through RAS; Constitutive Signaling by Overexpressed ERBB2; RAS GTPase cycle mutants; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants","Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; RalA downstream regulated genes; TNF-alpha signaling pathway; Aryl hydrocarbon receptor Netpath; Bladder cancer; Extracellular vesicle-mediated signaling in recipient cells; RAC1/PAK1/p38/MMP2 pathway; G protein signaling pathways; BDNF-TrkB signaling; MAPK signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MAPK cascade; Ras signaling; Non-small cell lung cancer; Breast cancer pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Synaptic signaling pathways associated with autism spectrum disorder; Hippo-Merlin signaling dysregulation; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; EGFR tyrosine kinase inhibitor resistance; Kisspeptin/kisspeptin receptor system in the ovary; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; ErbB signaling pathway; DNA damage response (only ATM dependent); Serotonin receptor 2 and ELK-SRF/GATA4 signaling",1715.9,1760,1709.7,1441.5,1523.1,1400.7,1.1879137745401234,0.24843012102254114,0.002245246504240993,2.648735971117389,0.05380493999835219,1.2691778485802019,305]
["P01116-2","Isoform 2B of GTPase KRas [OS=Homo sapiens]",61,8,40,4,188,21.4,8.12,99.1,"","","","KRAS","","","","",1371.2,1392.5,1480.5,1359.6,1405.8,1656.1,0.959900486260319,-0.05904324678314265,0.5789595070303901,0.23735181017278717,0.7055043409278295,0.1515003097123225,5998]
["P01130","Low-density lipoprotein receptor [OS=Homo sapiens]",20,16,21,16,860,95.3,5.05,57.91,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","LDLR","ENSG00000130164","Endocytosis; Ovarian steroidogenesis; Aldosterone synthesis and secretion; Cortisol synthesis and secretion; Cushing syndrome; Bile secretion; Cholesterol metabolism; Toxoplasmosis; Hepatitis C; Lipid and atherosclerosis","Retinoid metabolism and transport; Cargo recognition for clathrin-mediated endocytosis; LDL clearance; Chylomicron clearance","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Oncostatin M signaling pathway; PCSK9-mediated LDL receptor degradation; Evolocumab mechanism to reduce LDL cholesterol; Lipid particles composition; Wnt signaling pathway and pluripotency; Statin inhibition of cholesterol production; Bile acids synthesis and enterohepatic circulation ; Metabolic pathway of LDL, HDL and TG, including diseases; Orexin receptor pathway; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5; DNA damage response (only ATM dependent)",2350.8,2289.4,2331.7,3481.6,4009.7,2908,0.6704201244314522,-0.5768626388964955,0.02305543911237173,1.6372266018217632,0.15646444240698698,0.8055843432357717,1077]
["P01591","Immunoglobulin J chain [OS=Homo sapiens]",38,3,20,3,159,18.1,5.24,60.44,"cell organization and biogenesis;stress response;other biological processes","non-structural extracellular","signal transduction activity or receptor binding;other molecular function","JCHAIN","ENSG00000132465","","Cell surface interactions at the vascular wall; Scavenging of heme from plasma","",1189.3,1159.9,1203.2,1289,1348.9,1275,0.9078688440798384,-0.13944420228603843,0.009881410520209062,2.0051810576978037,0.10421822437548058,0.9820563304256373,693]
["P01834","immunoglobulin kappa constant [OS=Homo sapiens]",19,1,1,1,107,11.8,6.52,5.11,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","IGKC","","","Initial triggering of complement; Classical antibody-mediated complement activation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; Scavenging of heme from plasma; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Regulation of Complement cascade; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers","",24.5,19.3,17.8,16.3,26.6,23.5,0.9277108433734937,-0.10825289065202374,0.6849238787303094,0.1643576925723585,0.7785549968335662,0.10871070361260764,6430]
["P01854","immunoglobulin heavy constant epsilon [OS=Homo sapiens]",4,1,1,1,428,47,8.06,2.5,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","IGHE","ENSG00000211891; ENSG00000276192","","FCERI mediated NF-kB activation; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; Interleukin-4 and Interleukin-13 signaling","",156.1,165.2,144.2,170.6,157.6,79.9,1.1406518010291595,0.18985845718805555,0.5449513962856787,0.26364223032192236,0.6817955760787445,0.16634582107548035,5842]
["P01857","Immunoglobulin heavy constant gamma 1 [OS=Homo sapiens]",11,2,6,2,330,36.1,8.19,24.71,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","IGHG1","ENSG00000211896; ENSG00000277633","","Initial triggering of complement; Classical antibody-mediated complement activation; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Regulation of Complement cascade; Interleukin-4 and Interleukin-13 signaling","Interactions of natural killer cells in pancreatic cancer",414.1,412.6,351.8,438.1,478.4,278.6,0.9861099489582462,-0.020179582185344803,0.9356201201512548,0.028900447426469494,0.9591090404187268,0.018132015394362065,7130]
["P01889","HLA class I histocompatibility antigen, B-7 alpha chain [OS=Homo sapiens]",43,13,95,3,362,40.4,5.85,312.16,"stress response;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","HLA-B","ENSG00000234745","Endocytosis; Phagosome; Cellular senescence; Cell adhesion molecules; Antigen processing and presentation; Natural killer cell mediated cytotoxicity; Type I diabetes mellitus; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Viral carcinogenesis; Autoimmune thyroid disease; Allograft rejection; Graft-versus-host disease; Viral myocarditis","DAP12 interactions; Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ER-Phagosome pathway; Interferon gamma signaling; Interferon alpha/beta signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Endosomal/Vacuolar pathway","Proteasome degradation; Allograft Rejection; Ebola virus pathway in host; Type II interferon signaling (IFNG)",3454.5,3437.7,3725.4,2784,3336.8,5387.5,0.9226036860352964,-0.11621703854035151,0.7285351478307773,0.13754949105838768,0.8108517428803337,0.09105854546200885,6567]
["P01903","HLA class II histocompatibility antigen, DR alpha chain [OS=Homo sapiens]",26,5,14,5,254,28.6,5,51.51,"other biological processes","plasma membrane;other membranes;other cytoplasmic organelle","","HLA-DRA","","","","",1343.3,1315.7,1402.6,1142.2,1217.1,1160.1,1.1540603511962264,0.20671867120597978,0.00612781646626082,2.212694250699835,0.08498711679677483,1.0706469040284088,527]
["P01911","HLA class II histocompatibility antigen, DRB1-15 beta chain [OS=Homo sapiens]",23,6,13,2,266,29.9,7.74,31.26,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","HLA-DRB1","ENSG00000196126","Phagosome; Cell adhesion molecules; Antigen processing and presentation; Hematopoietic cell lineage; Th1 and Th2 cell differentiation; Th17 cell differentiation; Intestinal immune network for IgA production; Type I diabetes mellitus; Leishmaniasis; Toxoplasmosis; Staphylococcus aureus infection; Tuberculosis; Influenza A; Human T-cell leukemia virus 1 infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Asthma; Autoimmune thyroid disease; Inflammatory bowel disease; Systemic lupus erythematosus; Rheumatoid arthritis; Allograft rejection; Graft-versus-host disease; Viral myocarditis","Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling","Allograft Rejection; Vitamin D receptor pathway; Ebola virus pathway in host; Cancer immunotherapy by PD-1 blockade; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Genes associated with the development of rheumatoid arthritis; Network map of SARS-CoV-2 signaling pathway; Cytokines and inflammatory response",412.1,438.1,484.7,399.2,444.3,699.3,0.8652450090744103,-0.20881938025840124,0.5095318111045838,0.2928286969256339,0.6560098656620403,0.1830896292670738,5677]
["P02042","Hemoglobin subunit delta [OS=Homo sapiens]",13,2,25,1,147,16,8.05,63.89,"other metabolic processes;transport;other biological processes","cytosol;other cell component","other molecular function","HBD","ENSG00000223609","","Factors involved in megakaryocyte development and platelet production","VEGFA-VEGFR2 signaling pathway",1006.8,977.6,948.8,710.8,844.7,685.9,1.308646381725707,0.38807530946662117,0.011437790573332655,1.941657859675923,0.11221316953085689,0.9499561705402428,745]
["P02533","Keratin, type I cytoskeletal 14 [OS=Homo sapiens]",42,19,57,6,472,51.5,5.16,160.3,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KRT14","ENSG00000186847","Estrogen signaling pathway; Staphylococcus aureus infection","Formation of the cornified envelope; Type I hemidesmosome assembly","Corticotropin-releasing hormone signaling pathway",3148.3,2220.2,3294.6,2558.6,3424,8519.1,0.597385134156685,-0.743266758050976,0.36124316954825497,0.44220035587704687,0.5587992224821579,0.25274420683835563,4725]
["P02538","Keratin, type II cytoskeletal 6A [OS=Homo sapiens]",33,23,73,4,564,60,8,179.44,"cell organization and biogenesis;stress response;other biological processes","cytosol;cytoskeleton","cytoskeletal activity","KRT6A","ENSG00000205420","","Formation of the cornified envelope","Ectoderm differentiation; Ectoderm differentiation",2354,1924.7,3220.1,2384.4,3413.9,15991.8,0.3441379341994759,-1.538941166296752,0.3389707472404564,0.469837779260687,0.5484917404428815,0.2608299079381082,4517]
["P02545","Prelamin-A/C [OS=Homo sapiens]",66,46,249,43,664,74.1,7.02,742.27,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","LMNA","ENSG00000160789","Apoptosis; Hypertrophic cardiomyopathy; Arrhythmogenic right ventricular cardiomyopathy; Dilated cardiomyopathy","Signaling by BRAF and RAF1 fusions; XBP1(S) activates chaperone genes","Arrhythmogenic right ventricular cardiomyopathy; Adipogenesis; Fas ligand pathway and stress induction of heat shock proteins; Lamin A-processing pathway; Nephrotic syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome",25683.4,25113.7,25567.2,26818.7,26635.8,27545.9,0.9427644801754066,-0.08503069060573921,0.009210975415211858,2.0356943768592464,0.100782963038598,0.9966128774508192,668]
["P02647","Apolipoprotein A-I [OS=Homo sapiens]",8,2,13,1,267,30.8,5.76,31.99,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;other molecular function","APOA1","ENSG00000118137","PPAR signaling pathway; Fat digestion and absorption; Vitamin digestion and absorption; Cholesterol metabolism; African trypanosomiasis; Lipid and atherosclerosis","PPARA activates gene expression; Platelet degranulation ; Scavenging of heme from plasma; Amyloid fiber formation; Scavenging by Class B Receptors; Heme signaling; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Retinoid metabolism and transport; HDL clearance; Defective ABCA1 causes TGD; HDL assembly; Scavenging by Class A Receptors; ABC transporters in lipid homeostasis; Chylomicron assembly; Chylomicron remodeling; HDL remodeling","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Complement system; PPAR-alpha pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Statin inhibition of cholesterol production; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5",378.8,404.8,420.4,335.9,388.3,191,1.3155594405594404,0.3956764348686749,0.18527254904896304,0.7321889232591523,0.4290738469578171,0.36746795591256204,3156]
["P02649","Apolipoprotein E [OS=Homo sapiens]",5,2,4,2,317,36.1,5.73,10.12,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;cytoskeletal activity;other molecular function","APOE","ENSG00000130203","Cholesterol metabolism; Alzheimer disease","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Amyloid fiber formation; Retinoid metabolism and transport; Nuclear signaling by ERBB4; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Chylomicron clearance; Scavenging by Class A Receptors; Chylomicron assembly; Chylomicron remodeling; HDL remodeling; Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors","Vitamin B12 metabolism; Alzheimer's disease and miRNA effects; Apoptosis-related network due to altered Notch3 in ovarian cancer; ApoE and miR-146 in inflammation and atherosclerosis; Statin inhibition of cholesterol production; Familial hyperlipidemia type 3; Alzheimer's disease",399.6,421.2,454.1,381.4,406.5,448.1,1.0314724919093852,0.044705346852032195,0.63251599513603,0.19892848752529677,0.7415879705565036,0.1298373235821448,6234]
["P02656","Apolipoprotein C-III [OS=Homo sapiens]",16,1,2,1,99,10.8,5.41,10.27,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","non-structural extracellular;other cytoplasmic organelle","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","APOC3","ENSG00000110245","PPAR signaling pathway; Cholesterol metabolism","Retinoid metabolism and transport; Chylomicron assembly; Chylomicron remodeling; HDL remodeling","PPAR-alpha pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Statin inhibition of cholesterol production",70.7,99.1,88.9,70.3,76.5,148.2,0.876949152542373,-0.1894349004518247,0.6698351471790314,0.17403206816457054,0.7664096885929149,0.11553901374704287,6388]
["P02671-1","Fibrinogen alpha chain [OS=Homo sapiens]",1,1,1,1,866,94.9,6.01,2.72,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGA","ENSG00000171560","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Coronavirus disease","ER-Phagosome pathway; Signaling by BRAF and RAF1 fusions; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Amyloid fiber formation; Integrin cell surface interactions; Platelet degranulation ; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Common Pathway of Fibrin Clot Formation; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway",99.8,151.1,146.2,152.1,110.1,101.3,1.0924346629986244,0.12754699671751135,0.6468292320812956,0.1892103613000713,0.750662886199141,0.12455505571662338,6298]
["P02675","Fibrinogen beta chain [OS=Homo sapiens]",7,4,12,4,491,55.9,8.27,24.85,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGB","ENSG00000171564","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Coronavirus disease","ER-Phagosome pathway; Platelet degranulation ; Common Pathway of Fibrin Clot Formation; Integrin cell surface interactions; Signaling by BRAF and RAF1 fusions; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway; Complement and coagulation cascades",1126.4,1731.7,1727.8,1798.2,1322.1,1446.4,1.0042043488733658,0.006052877961924897,0.9805323390949009,0.008538078223777407,0.9879667585393755,0.005257667584219991,7254]
["P02679","Fibrinogen gamma chain [OS=Homo sapiens]",2,1,2,1,453,51.5,5.62,5.09,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGG","ENSG00000171557","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Staphylococcus aureus infection; Coronavirus disease","ER-Phagosome pathway; Platelet degranulation ; Integrin cell surface interactions; Signaling by BRAF and RAF1 fusions; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Common Pathway of Fibrin Clot Formation; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway",72.8,151.2,174.9,196.3,118.6,109,0.941023826374145,-0.08769684296793209,0.8503712923875877,0.07039140954790939,0.9010385294376454,0.045256637695308376,6898]
["P02686-1","myelin basic protein [OS=Homo sapiens]",3,1,1,1,304,33.1,9.79,2,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","MBP","ENSG00000197971; ENSGGOG00000009590","","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Neural crest differentiation; Glial cell differentiation; Spinal cord injury; Interleukin-1 (IL-1) structural pathway; MECP2 and associated Rett syndrome; MAPK cascade; Complement system in neuronal development and plasticity",22.6,28.6,15.7,36.9,28.5,66.2,0.5083586626139817,-0.976081373093781,0.14720645554022893,0.832073144183139,0.38494883132147883,0.4145969945216082,2795]
["P02749","Beta-2-glycoprotein 1 [OS=Homo sapiens]",4,2,5,2,345,38.3,7.97,7.37,"protein metabolism;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;other cell component","enzyme regulator activity;other molecular function","APOH","ENSG00000091583","Cholesterol metabolism","Platelet degranulation","",553.1,551.2,581.3,494.6,717.9,548.3,0.9572921399363926,-0.06296883107425101,0.7310617546337776,0.13604593554024363,0.8130447907209801,0.08988552841929473,6572]
["P02751","fibronectin [OS=Homo sapiens]",12,20,36,20,2386,262.5,5.71,113.49,"","","","","","","","",1767.2,2428.6,2777.4,2711.6,2191.2,2600,0.9294130191395215,-0.10560824074620188,0.6269101242580426,0.2027947164843826,0.737618496169033,0.1321682016569306,6212]
["P02753","Retinol-binding protein 4 [OS=Homo sapiens]",4,1,1,1,201,23,6.07,1.83,"other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;other cell component","transporter activity;other molecular function","RBP4","ENSG00000138207","","Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision); Retinoid cycle disease events; Retinoid metabolism disease events","Sterol regulatory element-binding proteins (SREBP) signaling; Vitamin A and carotenoid metabolism",139.5,153.5,182.8,127,195.8,188,0.9314800313234142,-0.10240325327758933,0.6676430157731694,0.17545568980122267,0.7650992164136242,0.11628224282419011,6378]
["P02760","Protein AMBP [OS=Homo sapiens]",2,1,2,1,352,39,6.25,1.84,"cell adhesion;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","enzyme regulator activity;other molecular function","AMBP","ENSG00000106927","","Scavenging of heme from plasma","",355.1,407.8,386.3,404.6,452.5,286.5,1.0048968170689052,0.007047372901425649,0.9728995976177699,0.01193197622748842,0.9832581801698397,7.332431810822328E-3,7232]
["P02765","Alpha-2-HS-glycoprotein [OS=Homo sapiens]",5,3,23,3,367,39.3,5.72,66.88,"","","","","","","","",3789.5,4136.7,3695.5,3233.2,5121.5,1528.1,1.175952159307079,0.23382936890356742,0.6091366528574066,0.21528526742552576,0.7246386386287084,0.1398785125650084,6144]
["P02766","Transthyretin [OS=Homo sapiens]",4,1,2,1,147,15.9,5.76,2.01,"other metabolic processes;transport;signal transduction","non-structural extracellular;other cytoplasmic organelle","signal transduction activity or receptor binding;other molecular function","TTR","ENSG00000118271","Thyroid hormone synthesis","Neutrophil degranulation; Amyloid fiber formation; Retinoid metabolism and transport; Non-integrin membrane-ECM interactions; The canonical retinoid cycle in rods (twilight vision); Retinoid cycle disease events","",115.3,157.5,111.3,147.9,165.1,106.3,0.9160505604579059,-0.1265008663153249,0.63496267799542,0.19725180103399934,0.7427884464578306,0.12913486001927024,6248]
["P02768-1","Serum albumin [OS=Homo sapiens]",12,9,57,9,609,69.3,6.28,144.76,"stress response;other biological processes","non-structural extracellular;ER/Golgi;other cell component","nucleic acid binding activity;other molecular function","ALB","ENSG00000163631","Thyroid hormone synthesis","Cytoprotection by HMOX1; Scavenging of heme from plasma; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Recycling of bile acids and salts; Heme degradation; HDL remodeling; Heme biosynthesis","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Complement system; VEGFA-VEGFR2 signaling pathway",8182.9,8883.8,9044.5,9218.8,11913.2,8098.5,0.8932861223721796,-0.1628057457314265,0.421658378702899,0.37503926545835065,0.5949616003744187,0.22551106331961074,5180]
["P02771","Alpha-fetoprotein [OS=Homo sapiens]",3,2,5,2,609,68.6,5.68,14.64,"other metabolic processes;developmental processes;signal transduction","non-structural extracellular;ER/Golgi;other cell component","other molecular function","AFP","ENSG00000081051","Hippo signaling pathway","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",848.1,902.5,974,1049.3,1271.3,2405.2,0.5765373058529774,-0.7945141318884433,0.18864936280118696,0.724344657372054,0.4330521962041066,0.36345975455371243,3184]
["P02774","vitamin D-binding protein [OS=Homo sapiens]",8,2,7,2,474,52.9,5.54,29.89,"transport","non-structural extracellular","transporter activity;cytoskeletal activity;other molecular function","HEL-S-51","","","","",327.5,393.7,373.4,380,450.5,1837.1,0.4103313840155945,-1.2851385925406582,0.33140392296614435,0.4796423549617475,0.5455475839998984,0.26316736319239437,4440]
["P02786","Transferrin receptor protein 1 [OS=Homo sapiens]",34,25,82,25,760,84.8,6.61,240.32,"protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","TFRC","ENSG00000072274","HIF-1 signaling pathway; Endocytosis; Phagosome; Ferroptosis; Hematopoietic cell lineage","RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; RHOC GTPase cycle; RND2 GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RND1 GTPase cycle; Transferrin endocytosis and recycling; RHOH GTPase cycle","Iron metabolism in placenta; Ferroptosis; 3q29 copy number variation syndrome",9810.1,10157.5,10072.7,9305.5,8895.7,9027,1.1032789534379794,0.14179760857225884,0.004216056207000729,2.3750936078933407,0.0719980252732905,1.1426794150225397,428]
["P02787","Serotransferrin [OS=Homo sapiens]",2,1,2,1,698,77,7.12,2.06,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","TF","ENSG00000091513","HIF-1 signaling pathway; Ferroptosis; Mineral absorption","Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cargo recognition for clathrin-mediated endocytosis; Transferrin endocytosis and recycling","Iron metabolism in placenta; Pluripotent stem cell differentiation pathway; Ferroptosis; IL-18 signaling pathway; 3q29 copy number variation syndrome; Sudden infant death syndrome (SIDS) susceptibility pathways",115.5,120.4,122,147,169.1,386.6,0.5093211896968834,-0.9733523548074564,0.2072915213934641,0.6834184609902509,0.4528074506469902,0.34408643573265374,3346]
["P02788","Lactotransferrin [OS=Homo sapiens]",1,1,1,1,710,78.1,8.12,2.05,"protein metabolism;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","LTF","ENSG00000012223","","Neutrophil degranulation; Amyloid fiber formation; Mtb iron assimilation by chelation; Metal sequestration by antimicrobial proteins","Male infertility",147.4,185.1,159.8,164,183.7,136.2,1.0173589584624922,0.024828800358070075,0.8818989184288335,0.05458119002045133,0.9238640095737916,0.034391951115622155,6977]
["P02792","Ferritin light chain [OS=Homo sapiens]",62,11,90,11,175,20,5.78,266.59,"transport;other biological processes","non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component","other molecular function","FTL","ENSG00000087086","Ferroptosis; Necroptosis; Mineral absorption","Neutrophil degranulation; Scavenging by Class A Receptors; Golgi Associated Vesicle Biogenesis; Iron uptake and transport","Nuclear receptors meta-pathway; NRF2 pathway; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway",15117.7,16387.4,14215.3,10647.9,12880.8,14601.4,1.1990632072824357,0.26190771082004055,0.12485360265937402,0.9035989215343991,0.3598402925226202,0.4438902088601212,2536]
["P02794","Ferritin heavy chain [OS=Homo sapiens]",43,5,13,5,183,21.2,5.55,47.17,"transport;other biological processes","non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component","other molecular function","FTH1","ENSG00000167996","Ferroptosis; Necroptosis; Mineral absorption","Neutrophil degranulation; Scavenging by Class A Receptors; Golgi Associated Vesicle Biogenesis; Iron uptake and transport","Iron metabolism in placenta; Nuclear receptors meta-pathway; NRF2 pathway; Ferroptosis",752.3,992.4,821.1,780.4,734,2290,0.6744296078225211,-0.5682602221288647,0.46851634652706214,0.32927525198505175,0.6271769188216662,0.20260993280581602,5460]
["P03891","NADH-ubiquinone oxidoreductase chain 2 [OS=Homo sapiens]",5,2,8,2,347,38.9,9.83,14.21,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;other cell component","signal transduction activity or receptor binding;transporter activity;other molecular function","MT-ND2","ENSG00000198763","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",704.4,784.1,837.5,654.9,639.3,481.9,1.309610945329655,0.38913828458110805,0.053097634685680115,1.2749248247911638,0.23649641189374526,0.6261754439602839,1641]
["P03897","NADH-ubiquinone oxidoreductase chain 3 [OS=Homo sapiens]",13,1,4,1,115,13.2,4.44,10.89,"other metabolic processes;stress response;transport;other biological processes","other membranes;mitochondrion","transporter activity","MT-ND3","ENSG00000198840","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",118.3,107.7,128.1,124,134.2,832.5,0.32465389199596595,-1.6230255901899988,0.35428116583821456,0.4506519348526836,0.5566296305054838,0.2544336790251215,4652]
["P03905","NADH-ubiquinone oxidoreductase chain 4 [OS=Homo sapiens]",7,3,13,3,459,51.5,9.35,35.17,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MT-ND4","ENSG00000198886","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",1174.5,1283.9,1444.8,1037.2,961,785.8,1.4020114942528734,0.48749817718993643,0.026082643614802416,1.5836483926511755,0.16752024796185488,0.7759326928262549,1138]
["P03923","NADH-ubiquinone oxidoreductase chain 6 [OS=Homo sapiens]",8,1,2,1,174,18.6,4.22,9.21,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","other membranes;mitochondrion","transporter activity","MT-ND6","ENSG00000198695","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",208.9,209.2,249.5,154,154.7,186.6,1.3478699777912377,0.4306813337281847,0.029097084604991098,1.5361505231582004,0.17752136175115185,0.7507493793275202,1198]
["P03928","ATP synthase protein 8 [OS=Homo sapiens]",13,1,2,1,68,8,9.91,5.52,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","MT-ATP8","ENSG00000228253","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome",1544.9,1022.9,573.1,605.9,1450.1,69.7,1.4775838547302067,0.5632400074725654,0.5279331945213199,0.27742103028127285,0.6694420053359347,0.17428704053925156,5764]
["P04004","Vitronectin [OS=Homo sapiens]",9,2,18,2,478,54.3,5.8,74.16,"cell adhesion;transport;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;extracellular structural activity;other molecular function","VTN","ENSG00000109072","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Complement and coagulation cascades; Human papillomavirus infection; Proteoglycans in cancer","Regulation of Complement cascade; Integrin cell surface interactions; ECM proteoglycans; Syndecan interactions; Molecules associated with elastic fibres","Primary focal segmental glomerulosclerosis (FSGS); Complement system; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; Inflammatory response pathway; Complement system in neuronal development and plasticity; Senescence and autophagy in cancer",1301.3,1330.1,1321.6,1039.9,1138.2,1014.6,1.2381370000313212,0.3081709577916171,2.7985557189290355E-3,2.553066041916972,0.05894710014309026,1.2295375548238727,347]
["P04040","catalase [OS=Homo sapiens]",49,20,80,20,527,59.7,7.39,257.61,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CAT","ENSG00000121691","Tryptophan metabolism; Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism; FoxO signaling pathway; Peroxisome; Longevity regulating pathway; Longevity regulating pathway; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Chemical carcinogenesis","Neutrophil degranulation; Peroxisomal protein import; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Detoxification of Reactive Oxygen Species","Selenium micronutrient network; Folate metabolism; Amyotrophic lateral sclerosis (ALS); Oxidative stress response; Tryptophan metabolism; Male infertility; DNA damage response (only ATM dependent)",7453.2,7338.1,7524.3,6944.4,6996.2,5750.6,1.1332778093767775,0.1805015637897111,0.1000549501612665,0.9997614200258612,0.3261827077291244,0.4865390664008426,2242]
["P04049","RAF proto-oncogene serine/threonine-protein kinase [OS=Homo sapiens]",18,10,19,7,648,73,9.2,53.28,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","RAF1","ENSG00000132155","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Cellular senescence; Vascular smooth muscle contraction; Axon guidance; VEGF signaling pathway; Apelin signaling pathway; Focal adhesion; Gap junction; Signaling pathways regulating pluripotency of stem cells; Neutrophil extracellular trap formation; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Long-term potentiation; Neurotrophin signaling pathway; Serotonergic synapse; Long-term depression; Regulation of actin cytoskeleton; Insulin signaling pathway; GnRH signaling pathway; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Melanogenesis; Prolactin signaling pathway; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Relaxin signaling pathway; Parathyroid hormone synthesis, secretion and action; GnRH secretion; Growth hormone synthesis, secretion and action; Alzheimer disease; Pathways of neurodegeneration; Alcoholism; Salmonella infection; Tuberculosis; Hepatitis C; Hepatitis B; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer","Signaling by BRAF and RAF1 fusions; Stimuli-sensing channels; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; CD209 (DC-SIGN) signaling; Rap1 signalling; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GP1b-IX-V activation signalling; Negative feedback regulation of MAPK pathway","IL-5 signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Endothelin pathways; Pilocytic astrocytoma; Glioblastoma signaling pathways; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Retinoblastoma gene in cancer; Aryl hydrocarbon receptor Netpath; Common pathways underlying drug addiction; Cardiac hypertrophic response; Bladder cancer; IL-3 signaling pathway; Extracellular vesicle-mediated signaling in recipient cells; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; Pathways affected in adenoid cystic carcinoma; TGF-beta signaling pathway; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; ERK pathway in Huntington's disease; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway; Fragile X syndrome; 22q11.2 copy number variation syndrome; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; Netrin-UNC5B signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Regucalcin in proximal tubule epithelial kidney cells; Kisspeptin/kisspeptin receptor system in the ovary; CAMKK2 pathway; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Angiotensin II receptor type 1 pathway; Malignant pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; EPO receptor signaling; Senescence and autophagy in cancer; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling",1656,1686.2,1633.6,1874.2,1826.1,2988.4,0.7439113729125238,-0.4267973411290595,0.20735290652695898,0.6832898726232196,0.45280621266971716,0.34408762309702373,3347]
["P04053","DNA nucleotidylexotransferase [OS=Homo sapiens]",3,1,1,1,509,58.5,8.43,2.25,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DNTT","ENSG00000107447","Non-homologous end-joining; Hematopoietic cell lineage","","",10.9,16.6,14.9,7.4,8.3,10.3,1.6307692307692307,0.7055526415347446,0.04475841875259975,1.3491252648414271,0.21882226265066992,0.6599084956179027,1495]
["P04062","glucosylceramidase [OS=Homo sapiens]",21,10,25,10,536,59.7,7.61,73.39,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","signal transduction activity or receptor binding;other molecular function","GBA","ENSG00000177628","Other glycan degradation; Sphingolipid metabolism; Metabolic pathways; Lysosome","Glycosphingolipid metabolism; Association of TriC/CCT with target proteins during biosynthesis","Sphingolipid pathway",3200.2,3253.5,3317.2,2972.1,3108.7,4172.5,0.952951732612915,-0.06952495198349645,0.6946312711384459,0.15824566937370022,0.7853147657774016,0.10495623670614011,6465]
["P04066","tissue alpha-L-fucosidase [OS=Homo sapiens]",21,9,25,9,466,53.7,6.84,71.08,"other metabolic processes","non-structural extracellular;other cytoplasmic organelle;other cell component","other molecular function","FUCA1","ENSG00000179163","Other glycan degradation; Lysosome","Neutrophil degranulation; Reactions specific to the complex N-glycan synthesis pathway","p53 transcriptional gene network",3201.3,3222.1,3209.4,2821,2693.4,2298.4,1.2329510546795002,0.3021155292032569,0.018244446775789836,1.7388693011600846,0.14096053011019863,0.8509024756779044,946]
["P04075","fructose-bisphosphate aldolase A [OS=Homo sapiens]",77,29,534,21,364,39.4,8.09,1806.83,"cell organization and biogenesis;other metabolic processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ALDOA","ENSG00000149925","Glycolysis / Gluconeogenesis; Pentose phosphate pathway; Fructose and mannose metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; HIF-1 signaling pathway","Neutrophil degranulation; Glycolysis; Platelet degranulation ; Gluconeogenesis","VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; 16p11.2 proximal deletion syndrome; Glycolysis and gluconeogenesis; Sudden infant death syndrome (SIDS) susceptibility pathways",59989.4,58205.2,61812.8,59033.5,57098.5,60892.3,{"$f":"AVERAGE(S962:U962)/AVERAGE(V962:X962)","v":1.016851358824749},{"$f":"LOG(Y962,2)","v":0.024108804506013628},{"$f":"TTEST(V962:X962,S962:U962,2,2)","v":0.5465197631550498},0.2623941285468635,{"$f":"AA962*7309/AE962","v":0.6830562498119458},0.1655435306126946,5848]
["P04080","Cystatin-B [OS=Homo sapiens]",52,4,24,4,98,11.1,7.56,83.31,"other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","CSTB","ENSG00000160213","","Neutrophil degranulation","",3625.5,4771,3448.9,3610.7,3643.5,3212.9,1.131679261686618,0.17846513030706085,0.3523360571871915,{"$f":"-LOG10(AA963)","v":0.45304290993789137},0.5558437819946433,{"$f":"-LOG10(AC963)","v":0.25504724825707364},4633]
["P04114","apolipoprotein B-100 [OS=Homo sapiens]",1,2,2,2,4563,515.3,7.05,5.51,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;other molecular function","APOB","ENSG00000084674","Fat digestion and absorption; Vitamin digestion and absorption; Cholesterol metabolism; Lipid and atherosclerosis","Heme signaling; Cell surface interactions at the vascular wall; Scavenging by Class B Receptors; Regulation of TLR by endogenous ligand; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Retinoid metabolism and transport; Cargo recognition for clathrin-mediated endocytosis; LDL clearance; Chylomicron clearance; Scavenging by Class A Receptors; Chylomicron assembly; Chylomicron remodeling; VLDL assembly; VLDL clearance; Scavenging by Class F Receptors; Scavenging by Class H Receptors; Platelet sensitization by LDL; LDL remodeling","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Statin inhibition of cholesterol production; Male infertility; Familial hyperlipidemia type 2",203.9,222.9,283.3,201.1,184.1,460.9,0.8392624985226335,-0.2528059778023615,0.6504598641918963,0.18677949587064502,0.7524867279801472,0.12350115555580223,6318]
["P04150","Glucocorticoid receptor [OS=Homo sapiens]",27,15,26,15,777,85.6,6.38,70.1,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","NR3C1","ENSG00000113580","Neuroactive ligand-receptor interaction","Potential therapeutics for SARS; Regulation of RUNX2 expression and activity; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Circadian Clock; SUMOylation of intracellular receptors; PTK6 Expression","Nuclear receptors; Adipogenesis; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Endoderm differentiation; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Transcription factor regulation in adipogenesis; White fat cell differentiation; Vitamin D in inflammatory diseases; 16p11.2 proximal deletion syndrome; Sudden infant death syndrome (SIDS) susceptibility pathways; Serotonin receptor 4/6/7 and NR3C signaling",1732.8,1742.6,1756.1,1932.4,1955.2,1829.2,0.9151098516652671,-0.12798315702067767,0.014716635077487989,1.8321914790158629,0.1258057143641634,0.9002996318600626,855]
["P04156-1","Major prion protein [OS=Homo sapiens]",20,5,16,5,253,27.6,9,32.24,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function","PRNP","ENSG00000171867","Ferroptosis; Prion disease; Pathways of neurodegeneration","NCAM1 interactions; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","Complement system; Copper homeostasis; Prion disease pathway; Ferroptosis",1315.1,1303.1,1429.3,1452.4,1590.8,1661.7,0.8602733320580672,-0.21713297908117546,0.04059555362186991,1.3915215315271041,0.2096910964114821,0.6784200095034401,1415]
["P04179","Superoxide dismutase [Mn], mitochondrial [OS=Homo sapiens]",39,7,31,7,222,24.7,8.25,102.06,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","mitochondrion","other molecular function","SOD2","ENSPPAG00000038347","FoxO signaling pathway; Peroxisome; Longevity regulating pathway; Longevity regulating pathway; Huntington disease; Chemical carcinogenesis; Lipid and atherosclerosis","","",4373.6,4855.5,4206,3830.3,3969.7,4373,1.1036802760207016,0.14232229982939085,0.17263797508685197,0.7628636665777766,0.4146601905717388,0.3823076570519707,3043]
["P04181-1","Ornithine aminotransferase, mitochondrial [OS=Homo sapiens]",51,15,92,15,439,48.5,7.03,291.77,"other metabolic processes;other biological processes","mitochondrion;nucleus;other cell component","other molecular function","OAT","ENSG00000065154; ENSPPAG00000034558; ENSPTRG00000003028","Arginine and proline metabolism; Metabolic pathways","Glutamate and glutamine metabolism","Amino acid metabolism; 22q11.2 copy number variation syndrome",9568.9,9425.1,9488.1,8646.5,7964.1,6560.2,1.2292238507086506,0.29774766501883576,0.0451883088217533,1.3449739118912831,0.21989437362063574,0.6577858826754597,1502]
["P04183","Thymidine kinase, cytosolic [OS=Homo sapiens]",43,9,38,9,234,25.5,8.51,104.68,"cell organization and biogenesis;DNA metabolism;other metabolic processes","cytosol","kinase activity;other molecular function","TK1","ENSG00000167900","Pyrimidine metabolism; Drug metabolism; Metabolic pathways","Pyrimidine salvage; G1/S-Specific Transcription","Fluoropyrimidine activity; Pyrimidine metabolism",3270.8,3248.1,3333.7,2661.7,2327.1,1782.2,1.4551174124944617,0.5411355679715742,0.01629218845608848,1.7880205749569003,0.1329013453410164,0.8764706227350525,896]
["P04233-2","Isoform 2 of HLA class II histocompatibility antigen gamma chain [OS=Homo sapiens]",48,10,116,10,232,26.4,9.14,330.43,"","","","CD74","","","","",15347.8,15839.2,15175.6,12989.7,15204.5,13950.3,1.1000866067932944,0.13761710763419827,0.1043152754853302,0.981652090679587,0.3336719249550453,0.4766803332014832,2285]
["P04259","keratin, type II cytoskeletal 6B [OS=Homo sapiens]",31,21,79,2,564,60,8,188.7,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","cytoskeletal activity","KRT6B","ENSG00000185479","","Formation of the cornified envelope","",264.8,233.1,263.8,194.8,259.3,578.2,0.7378668991572216,-0.43856749708947573,0.49058750155787223,0.3092835202828967,0.6412203234775551,0.19299272113654872,5592]
["P04264","Keratin, type II cytoskeletal 1 [OS=Homo sapiens]",52,37,272,31,644,66,8.12,762.82,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","bone, tooth or skin structural activity;other molecular function","KRT1","ENSG00000167768","","Neutrophil degranulation; Formation of the cornified envelope","Corticotropin-releasing hormone signaling pathway",38285.2,25103.1,35457.5,27217.1,41089.7,33969.5,0.9664585050495569,-0.04922030331412284,0.8498888232529129,0.07063788205711471,0.9006578815652516,0.04544014616208324,6897]
["P04406-1","glyceraldehyde-3-phosphate dehydrogenase [OS=Homo sapiens]",79,22,1504,22,335,36,8.46,5838.71,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","GAPDH; HEL-S-162eP; LOC117800120","ENSAMEG00000025937; ENSG00000111640; ENSGGOG00000009553; ENSPPAG00000039909; ENSPTRG00000004577","Glycolysis / Gluconeogenesis; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; HIF-1 signaling pathway; Alzheimer disease; Pathogenic Escherichia coli infection; Salmonella infection; Diabetic cardiomyopathy","Glycolysis; Gluconeogenesis","Cori cycle; Alzheimer's disease and miRNA effects; HIF1A and PPARG regulation of glycolysis; VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; 7q11.23 copy number variation syndrome; Glycolysis in senescence; Alzheimer's disease; Glycolysis and gluconeogenesis; Sudden infant death syndrome (SIDS) susceptibility pathways",134314.5,132705.6,138509.7,125776.7,120659.5,111905.4,1.1316849620585498,0.17847239727561237,0.023341412812374195,1.631872860456528,0.15781904370549765,0.8018405925258655,1081]
["P04424","argininosuccinate lyase [OS=Homo sapiens]",19,8,21,8,464,51.6,6.48,62.06,"other metabolic processes","cytosol;other cell component","other molecular function","ASL","ENSG00000126522","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Metabolic pathways; Biosynthesis of amino acids","Urea cycle","Alanine and aspartate metabolism",1923.2,1939.8,1914,1753.1,1764.7,2077.2,1.0325290437890975,0.04618236347636935,0.5991270749586024,0.2224810539041645,0.717519218560122,0.14416646197678465,6103]
["P04632","Calpain small subunit 1 [OS=Homo sapiens]",77,12,90,12,268,28.3,5.2,324.41,"protein metabolism;other biological processes","plasma membrane;other membranes;cytosol","other molecular function","CAPNS1","ENSG00000126247","Shigellosis","Formation of the cornified envelope; Degradation of the extracellular matrix; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models","Integrin-mediated cell adhesion",8462.3,8393.3,8339.9,8200,8346.5,5359.8,1.150148587392668,0.2018202546018087,0.32271540201471205,0.4911803068292025,0.5424854814456141,0.26561188035948646,4348]
["P04637","Cellular tumor antigen p53 [OS=Homo sapiens]",6,3,3,3,393,43.6,6.79,7.18,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function","TP53","ENSG00000141510","Endocrine resistance; Platinum drug resistance; MAPK signaling pathway; Sphingolipid signaling pathway; Cell cycle; p53 signaling pathway; Mitophagy; PI3K-Akt signaling pathway; Apoptosis; Longevity regulating pathway; Ferroptosis; Cellular senescence; Wnt signaling pathway; Neurotrophin signaling pathway; Thyroid hormone signaling pathway; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Shigellosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Pathways in cancer; Transcriptional misregulation in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Colorectal cancer; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Thyroid cancer; Basal cell carcinoma; Melanoma; Bladder cancer; Chronic myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","TP53 Regulates Transcription of DNA Repair Genes; Autodegradation of the E3 ubiquitin ligase COP1; Ub-specific processing proteases; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of PTEN gene transcription; Factors involved in megakaryocyte development and platelet production; Interleukin-4 and Interleukin-13 signaling; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; TP53 Regulates Transcription of Death Receptors and Ligands; Oxidative Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Association of TriC/CCT with target proteins during biosynthesis; Pre-NOTCH Transcription and Translation; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; TP53 Regulates Transcription of Caspase Activators and Caspases; Regulation of TP53 Activity through Methylation; G2/M DNA damage checkpoint; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Activation of PUMA and translocation to mitochondria; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; Regulation of TP53 Activity through Association with Co-factors; Ovarian tumor domain proteases; Pyroptosis; SUMOylation of transcription factors; Regulation of TP53 Expression; RUNX3 regulates CDKN1A transcription; Activation of NOXA and translocation to mitochondria; Formation of Senescence-Associated Heterochromatin Foci (SAHF); PI5P Regulates TP53 Acetylation; Transcriptional  activation of  cell cycle inhibitor p21 ; Loss of function of TP53 in cancer due to loss of tetramerization ability","AMP-activated protein kinase (AMPK) signaling; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Fluoropyrimidine activity; TP53 network; Folate metabolism; Apoptosis modulation and signaling; Cell cycle; Metastatic brain tumor; Glioblastoma signaling pathways; Gastric cancer network 2; Oncostatin M signaling pathway; Spinal cord injury; Retinoblastoma gene in cancer; Amyotrophic lateral sclerosis (ALS); ATM signaling pathway; Apoptosis; Mammary gland development pathway - Involution (Stage 4 of 4); Bladder cancer; Copper homeostasis; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced HIF-1 survival signaling; Hepatitis C and hepatocellular carcinoma; Pathways affected in adenoid cystic carcinoma; TGF-beta signaling pathway; lncRNA-mediated mechanisms of therapeutic resistance; MAPK signaling pathway; miRNA regulation of p53 pathway in prostate cancer; Wnt signaling pathway and pluripotency; Endometrial cancer; PI3K-Akt signaling pathway; Caloric restriction and aging; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer; Ferroptosis; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; MicroRNA network associated with chronic lymphocytic leukemia; G1 to S cell cycle control; 22q11.2 copy number variation syndrome; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Unfolded protein response; 16p11.2 proximal deletion syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis in senescence; TCA cycle in senescence; Malignant pleural mesothelioma; Senescence and autophagy in cancer; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)",386.9,415.2,388.4,230.8,246.5,335.4,1.464870185800418,0.5507728212345255,0.020448319974285683,1.6893423676502457,0.14797700068520203,0.8298057795489152,1010]
["P04792","Heat shock protein beta-1 [OS=Homo sapiens]",29,5,7,5,205,22.8,6.4,25.69,"stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","HSPB1","ENSG00000106211","MAPK signaling pathway; VEGF signaling pathway; Amoebiasis","AUF1 (hnRNP D0) binds and destabilizes mRNA; MAPK6/MAPK4 signaling; Extra-nuclear estrogen signaling; VEGFA-VEGFR2 Pathway","Apoptosis-related network due to altered Notch3 in ovarian cancer; Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; ATM signaling in development and disease ; VEGFA-VEGFR2 signaling pathway; p38 MAPK signaling pathway; Extracellular vesicles in the crosstalk of cardiac cells; Ferroptosis; IL-18 signaling pathway; Intracellular trafficking proteins involved in CMT neuropathy",824.9,849,827.5,783.3,757.3,814.9,1.061940140097644,0.08670244597426191,0.05671760025063478,1.2462821526478902,0.24500528382499384,0.610824549466922,1692]
["P04818","thymidylate synthase [OS=Homo sapiens]",15,5,6,5,313,35.7,7.01,3.92,"DNA metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","TYMS","ENSG00000176890","Pyrimidine metabolism; One carbon pool by folate; Metabolic pathways; Antifolate resistance","Interconversion of nucleotide di- and triphosphates; G1/S-Specific Transcription","Fluoropyrimidine activity; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration and one-carbon metabolism; One-carbon metabolism and related pathways; Ethanol effects on histone modifications; Pyrimidine metabolism",320.9,297.3,330.6,583.7,632.5,590.8,0.5250691754288876,-0.9294205912059584,9.47061368520014e-05,4.023621878287037,0.014727811792580387,1.8318617743387817,47]
["P04839","Cytochrome b-245 heavy chain [OS=Homo sapiens]",4,2,4,2,570,65.3,8.63,5.85,"other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","CYBB","ENSG00000165168","HIF-1 signaling pathway; Phagosome; Ferroptosis; Necroptosis; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Leukocyte transendothelial migration; AGE-RAGE signaling pathway in diabetic complications; Alzheimer disease; Prion disease; Pathways of neurodegeneration; Leishmaniasis; Coronavirus disease; Diabetic cardiomyopathy; Lipid and atherosclerosis","Neutrophil degranulation; RAC2 GTPase cycle; RAC3 GTPase cycle; RAC1 GTPase cycle; Detoxification of Reactive Oxygen Species; VEGFA-VEGFR2 Pathway; ROS and RNS production in phagocytes; Cross-presentation of particulate exogenous antigens (phagosomes); RHO GTPases Activate NADPH Oxidases","Alzheimer's disease and miRNA effects; VEGFA-VEGFR2 signaling pathway; Microglia pathogen phagocytosis pathway; Oxidative stress response; Ferroptosis; Alzheimer's disease; Type II interferon signaling (IFNG)",571.9,549.6,591.8,525.6,510.7,422.4,1.1745389730582028,0.23209458504440475,0.06934928480768122,1.1589580134036617,0.2693272702759522,0.5697196706109269,1882]
["P04843","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [OS=Homo sapiens]",63,36,375,36,607,68.5,6.38,1108.82,"protein metabolism;other metabolic processes","other membranes;cytosol;ER/Golgi;other cell component","","RPN1","ENSG00000163902","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum","SRP-dependent cotranslational protein targeting to membrane; Asparagine N-linked glycosylation; Maturation of spike protein","Proteasome degradation",46029.3,45709.2,47051.9,41985.2,41427.5,36981.5,1.1527997195878206,0.20514188969772193,0.019903336440319958,1.7010741157428546,0.14635159561599453,0.8346025382561949,994]
["P04844-1","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [OS=Homo sapiens]",52,22,187,1,631,69.2,5.69,634.88,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus;other cytoplasmic organelle","translation activity","RPN2","ENSG00000118705","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum","SRP-dependent cotranslational protein targeting to membrane; Asparagine N-linked glycosylation; Maturation of spike protein","Proteasome degradation",513.8,590.7,570.7,395.3,382.7,127.3,1.8504363194521154,0.8878654878718857,0.046767633952114473,1.3300546011740946,0.22326886777008798,0.6511718299883826,1531]
["P04844-2","Isoform 2 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [OS=Homo sapiens]",49,22,161,1,615,67.7,6.06,563.89,"","","","RPN2","","","","",13623.9,14627.7,14064.5,11247,10539,9175.7,1.3667240493900528,0.45072198269190605,0.004933994390382044,2.3068013486094583,0.07805749999848996,1.107585362281611,462]
["P04899-1","guanine nucleotide-binding protein G(i) subunit alpha-2 [OS=Homo sapiens]",60,16,67,9,355,40.4,5.54,231.53,"cell-cell signaling;cell cycle OR cell proliferation;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","GNAI2","ENSCANG00000029469; ENSCATG00000043630; ENSCSAG00000014329; ENSG00000114353; ENSMFAG00000032665; ENSMMUG00000056280; ENSMNEG00000033996; ENSNLEG00000006962; ENSPANG00000023235; ENSPTRG00000014951; ENSRBIG00000038900; ENSRROG00000029350; ENSTSYG00000005938","Rap1 signaling pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Adrenergic signaling in cardiomyocytes; Axon guidance; Apelin signaling pathway; Gap junction; Platelet activation; Leukocyte transendothelial migration; Circadian entrainment; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; GABAergic synapse; Dopaminergic synapse; Long-term depression; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Melanogenesis; Oxytocin signaling pathway; Regulation of lipolysis in adipocytes; Renin secretion; Relaxin signaling pathway; Parathyroid hormone synthesis, secretion and action; Cushing syndrome; Growth hormone synthesis, secretion and action; Gastric acid secretion; Parkinson disease; Cocaine addiction; Morphine addiction; Alcoholism; Pertussis; Chagas disease; Toxoplasmosis; Human cytomegalovirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Chemical carcinogenesis","G alpha (i) signalling events; G alpha (z) signalling events; Adenylate cyclase inhibitory pathway; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; ADORA2B mediated anti-inflammatory cytokines production; Adrenaline,noradrenaline inhibits insulin secretion","Thyroid stimulating hormone (TSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; S1P receptor signal transduction; Complement system; G protein signaling pathways; Chemokine signaling pathway; Hippo signaling regulation pathways; Purinergic signaling; Calcium regulation in cardiac cells; Calcium regulation in cardiac cells",8425.6,8933.5,8475.5,7375.3,6896.3,7728.2,1.174310675551596,0.23181413824623606,0.011652603932588516,1.933577014793284,0.11265725151228766,0.9482408484105176,756]
["P04920-1","Anion exchange protein 2 [OS=Homo sapiens]",26,23,59,23,1241,136.9,6.29,248.64,"transport;developmental processes;other biological processes","plasma membrane;other membranes","transporter activity;other molecular function","SLC4A2","ENSG00000164889","Salivary secretion; Gastric acid secretion; Pancreatic secretion; Bile secretion","Bicarbonate transporters","Proximal tubule transport",3943.8,3920.8,3969.6,3627.6,3698.9,4072.9,1.038142358369739,0.05400429112522967,0.35537726524845525,0.44931035900950334,0.5570346197085481,0.2541178125800224,4663]
["P04921-1","Glycophorin-C [OS=Homo sapiens]",27,2,4,2,128,13.8,4.84,19.82,"","plasma membrane;other membranes;cytoskeleton","","GYPC","ENSG00000136732","Malaria","Cell surface interactions at the vascular wall","",411.1,393.3,458.5,441.9,473,758.7,0.7546008604206501,-0.4062143497301995,0.2532984726092497,0.596367428998929,0.49435474934606305,0.30596128915044135,3745]
["P05023","Sodium/potassium-transporting ATPase subunit alpha-1 [OS=Homo sapiens]",46,42,245,42,1023,112.8,5.49,823.18,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;cytoskeletal activity;other molecular function","ATP1A1","ENSG00000163399","cGMP-PKG signaling pathway; cAMP signaling pathway; Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Insulin secretion; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Aldosterone synthesis and secretion; Aldosterone-regulated sodium reabsorption; Endocrine and other factor-regulated calcium reabsorption; Proximal tubule bicarbonate reclamation; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Carbohydrate digestion and absorption; Protein digestion and absorption; Bile secretion; Mineral absorption","Ion homeostasis; Ion transport by P-type ATPases; Potential therapeutics for SARS","Pre-implantation embryo; Proximal tubule transport",24959.1,24781.5,26373.7,20977.8,21878.1,23742.2,1.1428899623262527,0.19268650727219822,0.02955441795815808,1.5293775891842953,0.17896705953287276,0.7472268973976717,1207]
["P05026","Sodium/potassium-transporting ATPase subunit beta-1 [OS=Homo sapiens]",8,3,5,3,303,35,8.53,5.59,"cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","transporter activity;other molecular function","ATP1B1","ENSG00000143153","cGMP-PKG signaling pathway; cAMP signaling pathway; Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Insulin secretion; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Aldosterone synthesis and secretion; Aldosterone-regulated sodium reabsorption; Endocrine and other factor-regulated calcium reabsorption; Proximal tubule bicarbonate reclamation; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Carbohydrate digestion and absorption; Protein digestion and absorption; Bile secretion; Mineral absorption","Ion homeostasis; Ion transport by P-type ATPases; Potential therapeutics for SARS; Basigin interactions","Proximal tubule transport; Calcium regulation in cardiac cells",572.1,558.8,581.9,505,511.5,626.3,1.042610177745313,0.06019984840645383,0.5906133442749343,0.22869674484215835,0.7119895981041554,0.14752635119315186,6063]
["P05062","fructose-bisphosphate aldolase B [OS=Homo sapiens]",6,3,32,1,364,39.4,7.87,72.4,"cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;cytoskeleton","cytoskeletal activity;other molecular function","ALDOB","ENSG00000136872","Glycolysis / Gluconeogenesis; Pentose phosphate pathway; Fructose and mannose metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; HIF-1 signaling pathway","Glycolysis; Gluconeogenesis; Fructose catabolism; Hereditary fructose intolerance","Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Glycolysis and gluconeogenesis; Polyol pathway",55.8,52.4,56.5,37,39.8,83.7,1.0261682242990653,0.03726725771668916,0.9309275817489366,0.03108410212295214,0.956176179736225,0.019462079650866645,7116]
["P05067-1","Amyloid-beta A4 protein [OS=Homo sapiens]",13,8,19,8,770,86.9,4.82,63.9,"cell adhesion;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function","APP","ENSG00000142192","Serotonergic synapse; Alzheimer disease; Pathways of neurodegeneration","Amyloid fiber formation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Platelet degranulation ; G alpha (q) signalling events; G alpha (i) signalling events; ECM proteoglycans; Lysosome Vesicle Biogenesis; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; TRAF6 mediated NF-kB activation; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Formyl peptide receptors bind formyl peptides and many other ligands; Advanced glycosylation endproduct receptor signaling","Alzheimer's disease and miRNA effects; Endoderm differentiation; Apoptosis-related network due to altered Notch3 in ovarian cancer; Copper homeostasis; TGF-beta signaling pathway; Fragile X syndrome; Inclusion body myositis; Alzheimer's disease",2041.7,1997.3,2106.8,2191.8,2379.7,2105.2,0.920484670570791,-0.11953439924987966,0.11179846588939162,0.9515641558444349,0.34189748417806,0.4661040949085996,2390]
["P05089","Arginase-1 [OS=Homo sapiens]",7,2,2,2,322,34.7,7.21,2.25,"other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","ARG1","ENSG00000118520","Arginine biosynthesis; Arginine and proline metabolism; Metabolic pathways; Biosynthesis of amino acids; Amoebiasis","Neutrophil degranulation; Urea cycle","Spinal cord injury; Amino acid metabolism; IL-18 signaling pathway",180,130.6,164.8,165.7,189,171.5,0.903458760927404,-0.14646934522345464,0.3548990592643591,0.4498951518410216,0.5567626581161624,0.2543299004052696,4659]
["P05091","Aldehyde dehydrogenase, mitochondrial [OS=Homo sapiens]",4,2,2,1,517,56.3,7.05,6.5,"other metabolic processes","mitochondrion","other molecular function","ALDH2","ENSG00000111275","Glycolysis / Gluconeogenesis; Ascorbate and aldarate metabolism; Fatty acid degradation; Valine, leucine and isoleucine degradation; Lysine degradation; Arginine and proline metabolism; Histidine metabolism; Tryptophan metabolism; beta-Alanine metabolism; Glycerolipid metabolism; Pyruvate metabolism; Pantothenate and CoA biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Alcoholic liver disease","Ethanol oxidation; Metabolism of serotonin","Fatty acid omega-oxidation; Ethanol effects on histone modifications; Tryptophan metabolism; Fluoroacetic acid toxicity",58.5,61.8,64.9,84,84.5,61.8,0.8041684759009986,-0.3144303125326094,0.12295875866967503,0.9102405299067465,0.35648772991537275,0.44795541369921954,2521]
["P05114","Non-histone chromosomal protein HMG-14 [OS=Homo sapiens]",51,6,23,6,100,10.7,9.6,67.88,"cell organization and biogenesis;DNA metabolism;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HMGN1","ENSG00000205581","","Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER","ATM signaling in development and disease ; p38 MAPK signaling pathway; Malignant pleural mesothelioma; Nucleotide excision repair in xeroderma pigmentosum",2975.5,2733.6,2771.9,2531,2860.3,1567.3,1.2187796395826747,0.28543730428500297,0.2683838108980779,0.5712436846642975,0.5050507914145344,0.2966649440162918,3884]
["P05141","ADP/ATP translocase 2 [OS=Homo sapiens]",52,18,249,5,298,32.8,9.69,692.48,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion","transporter activity;other molecular function","SLC25A5","ENSG00000005022","Calcium signaling pathway; cGMP-PKG signaling pathway; Necroptosis; Cellular senescence; Neutrophil extracellular trap formation; Alzheimer disease; Parkinson disease; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Influenza A; Human T-cell leukemia virus 1 infection; Chemical carcinogenesis; Diabetic cardiomyopathy","Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization","Electron transport chain: OXPHOS system in mitochondria; Alzheimer's disease and miRNA effects; Alzheimer's disease",40159.9,40876.1,39206.9,35261.3,33767.1,49370.8,1.0155718957560524,0.022292376491926884,0.9080016988862274,0.04191333890598129,0.9412259845638117,0.026306091699050786,7051]
["P05161","Ubiquitin-like protein ISG15 [OS=Homo sapiens]",10,2,3,2,165,17.9,7.44,6.18,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;cytosol;translational apparatus;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ISG15","ENSG00000187608","RIG-I-like receptor signaling pathway; Human papillomavirus infection; Epstein-Barr virus infection; Coronavirus disease","Interferon alpha/beta signaling; ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling","Novel intracellular components of RIG-I-like receptor (RLR) pathway; Non-genomic actions of 1,25 dihydroxyvitamin D3; Cytosolic DNA-sensing pathway; p53 transcriptional gene network; Type II interferon signaling (IFNG)",320.7,322.2,338.8,298.1,264.3,156.3,1.36593850006957,0.4498925292780728,0.11201670787123776,0.9507171952306142,0.3421354441416117,0.4658019319600785,2393]
["P05165-1","Propionyl-CoA carboxylase alpha chain, mitochondrial [OS=Homo sapiens]",28,16,30,16,728,80,7.52,89.32,"other metabolic processes","cytosol;mitochondrion","other molecular function","PCCA","ENSG00000175198","Valine, leucine and isoleucine degradation; Glyoxylate and dicarboxylate metabolism; Propanoate metabolism; Metabolic pathways; Carbon metabolism","Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency; Propionyl-CoA catabolism","",2516,2513.5,2632.3,2367.7,2313.9,2650.3,1.0449951581445465,0.06349625777311088,0.3796413068990047,0.42062654023230994,0.5670955062589056,0.2463437941082753,4893]
["P05166-1","propionyl-CoA carboxylase beta chain, mitochondrial [OS=Homo sapiens]",21,9,15,9,539,58.2,7.64,54.36,"other metabolic processes","cytosol;mitochondrion","other molecular function","PCCB","ENSG00000114054","Valine, leucine and isoleucine degradation; Glyoxylate and dicarboxylate metabolism; Propanoate metabolism; Metabolic pathways; Carbon metabolism","Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency; Propionyl-CoA catabolism","",1609.3,1567.7,1658.3,1562.6,1517.8,1395.8,1.080224297395112,0.11133090418684127,0.10064482808752839,0.9972085376233961,0.327084503553466,0.48534003117505536,2249]
["P05198","Eukaryotic translation initiation factor 2 subunit 1 [OS=Homo sapiens]",66,20,221,20,315,36.1,5.08,697.51,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;translational apparatus;nucleus;other cell component","translation activity;nucleic acid binding activity","EIF2S1","ENSG00000134001","Autophagy; Protein processing in endoplasmic reticulum; Apoptosis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Prion disease; Pathways of neurodegeneration; Hepatitis C; Measles; Influenza A; Herpes simplex virus 1 infection; Lipid and atherosclerosis","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency","Translation factors; Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; Ebola virus pathway in host; Nonalcoholic fatty liver disease; Unfolded protein response; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; Alzheimer's disease",19610.6,19626.9,19292.8,17837,17392,15061,1.163855637303639,0.21891211987642958,0.03399568146568268,1.4685762486855092,0.19276527217430156,0.7149712041549393,1289]
["P05204","Non-histone chromosomal protein HMG-17 [OS=Homo sapiens]",16,2,9,2,90,9.4,9.99,21.42,"cell organization and biogenesis;other biological processes","non-structural extracellular;nucleus;other cell component","nucleic acid binding activity;other molecular function","HMGN2","ENSG00000198830","","","",1324.8,1043.9,1600.2,1221.9,1158.2,975.8,1.1826633689919244,0.24203948619039958,0.311922549454407,0.5059532281616455,0.5349230206387284,0.27170871165585575,4262]
["P05362","Intercellular adhesion molecule 1 [OS=Homo sapiens]",24,9,19,9,532,57.8,7.99,72.98,"cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","ICAM1","ENSG00000090339","NF-kappa B signaling pathway; Cell adhesion molecules; Natural killer cell mediated cytotoxicity; TNF signaling pathway; Leukocyte transendothelial migration; AGE-RAGE signaling pathway in diabetic complications; African trypanosomiasis; Malaria; Staphylococcus aureus infection; Influenza A; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Rheumatoid arthritis; Viral myocarditis; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","Interleukin-4 and Interleukin-13 signaling; Interferon gamma signaling; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Integrin cell surface interactions; Interleukin-10 signaling","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; RANKL/RANK signaling pathway; Interleukin-11 signaling pathway; Spinal cord injury; Complement system; IL1 and megakaryocytes in obesity; Photodynamic therapy-induced NF-kB survival signaling; VEGFA-VEGFR2 signaling pathway; miRNAs involvement in the immune response in sepsis; Cells and molecules involved in local acute inflammatory response ; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; CAMKK2 pathway; p53 transcriptional gene network; Orexin receptor pathway; Type II interferon signaling (IFNG)",2121.3,2151.1,2238.4,2336.2,2363.9,1999.8,0.9717756981447483,-0.04130474043632004,0.6331387935853604,0.19850107563680475,0.7417232637146016,0.12975809938319502,6239]
["P05386","60S acidic ribosomal protein P1 [OS=Homo sapiens]",57,3,24,3,114,11.5,4.32,86.06,"protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus","enzyme regulator activity;other molecular function","RPLP1","ENSG00000137818","Ribosome; Coronavirus disease","L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",2769.4,4272.7,2419.2,3507.1,3955.9,3739.2,0.84459302636982,-0.2436717597339543,0.3759732190567822,0.42484308919491093,0.5650808673835125,0.24788939687911532,4863]
["P05455","Lupus La protein [OS=Homo sapiens]",70,34,273,34,408,46.8,7.12,717.54,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","nucleus;other cell component","nucleic acid binding activity","SSB","ENSG00000138385","Systemic lupus erythematosus","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination","",38943.6,38346.8,38648.8,38798.5,38169.2,27350.4,1.1114006102488445,0.15237893755754467,0.3564790569047251,0.4479659798033792,0.5579240742862175,0.2534248984855184,4670]
["P06213-1","insulin receptor [OS=Homo sapiens]",10,12,19,11,1382,156.2,6.2,54.6,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","INSR","ENSG00000171105","MAPK signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cGMP-PKG signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Phospholipase D signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Adherens junction; Insulin signaling pathway; Ovarian steroidogenesis; Regulation of lipolysis in adipocytes; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; Aldosterone-regulated sodium reabsorption; Alzheimer disease; Diabetic cardiomyopathy","PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Insulin receptor recycling; IRS activation; Signal attenuation","AMP-activated protein kinase (AMPK) signaling; Selenium micronutrient network; Vitamin B12 metabolism; Type II diabetes mellitus; Folate metabolism; Alzheimer's disease and miRNA effects; AGE/RAGE pathway; Nanoparticle triggered autophagic cell death; Transcription factor regulation in adipogenesis; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; PI3K-Akt signaling pathway; Ras signaling; NRF2-ARE regulation; Nonalcoholic fatty liver disease; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Male infertility; Insulin signaling; 16p11.2 distal deletion syndrome; Neuroinflammation and glutamatergic signaling; Malignant pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)",1818.1,1788.1,1812.8,1830.5,1811.1,1720.2,1.0106680592338393,0.015309240632541691,0.6171194347997622,0.20963077623447757,0.7302130401410818,0.13655041568819837,6177]
["P06396","Gelsolin [OS=Homo sapiens]",10,8,12,8,782,85.6,6.28,27.52,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","GSN","ENSG00000148180","Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Viral carcinogenesis","Neutrophil degranulation; Amyloid fiber formation; Sensory processing of sound by outer hair cells of the cochlea; Caspase-mediated cleavage of cytoskeletal proteins","Ebola virus pathway in host; Regulation of actin cytoskeleton; Senescence and autophagy in cancer",1623.3,1637.6,1634.1,1461.6,1570.1,1354.6,1.1159747395299002,0.15830437164076364,0.05302981737493907,1.2754798685101907,0.2364825718080718,0.6262008601967167,1639]
["P06737-1","Glycogen phosphorylase, liver form [OS=Homo sapiens]",8,7,11,4,847,97.1,7.17,27.47,"other metabolic processes;other biological processes","non-structural extracellular;cytosol;other cell component","other molecular function","PYGL","ENSG00000100504; ENSPPAG00000035478; ENSPTRG00000006337","Starch and sucrose metabolism; Metabolic pathways; Necroptosis; Insulin signaling pathway; Glucagon signaling pathway; Insulin resistance","Neutrophil degranulation; Glycogen breakdown (glycogenolysis)","TNF-alpha signaling pathway; Glycogen synthesis and degradation; Glycogen metabolism",145.8,144.7,178.8,136.8,136.6,233.9,0.9250936329588015,-0.11232870010287624,0.7304604872396594,0.136403271362668,0.8124997262569884,0.09017677666921038,6571]
["P06858","lipoprotein lipase [OS=Homo sapiens]",1,1,1,1,475,53.1,8.15,1.76,"cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","LPL","ENSG00000175445","Glycerolipid metabolism; PPAR signaling pathway; Cholesterol metabolism; Alzheimer disease","Transcriptional regulation of white adipocyte differentiation; Retinoid metabolism and transport; Assembly of active LPL and LIPC lipase complexes; Chylomicron remodeling","Fatty acid beta-oxidation; Sterol regulatory element-binding proteins (SREBP) signaling; Alzheimer's disease and miRNA effects; Adipogenesis; Aryl hydrocarbon receptor Netpath; Triacylglyceride synthesis; Lipid particles composition; Angiopoietin-like protein 8 regulatory pathway; PPAR signaling pathway; Statin inhibition of cholesterol production; Metabolic pathway of LDL, HDL and TG, including diseases; Overview of leukocyte-intrinsic Hippo pathway functions; Orexin receptor pathway; Familial partial lipodystrophy (FPLD); Familial  hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5; Alzheimer's disease; Vitamin A and carotenoid metabolism",86.6,76,77.3,78.7,91.2,91,0.9195093905711,-0.12106378652401754,0.2580668399288544,0.5882677961578572,0.497418389514767,0.3032781629399129,3792]
["P07099","epoxide hydrolase 1 [OS=Homo sapiens]",39,15,66,15,455,52.9,7.25,209.82,"other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","EPHX1","ENSG00000143819","Metabolism of xenobiotics by cytochrome P450; Bile secretion; Chemical carcinogenesis; Chemical carcinogenesis; Chemical carcinogenesis","Phase I - Functionalization of compounds","Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Benzene metabolism; Benzo(a)pyrene metabolism; Aflatoxin B1 metabolism; Metapathway biotransformation Phase I and II",7710.5,7692.6,7973.2,6094.4,6182.6,6299.1,1.2584073083155238,0.3315989544739509,1.2239975140754388E-4,3.9122194642365486,0.01597535326853104,1.7965495293587763,56]
["P07311","Acylphosphatase-1 [OS=Homo sapiens]",26,3,5,3,99,11.3,9.31,14.66,"other metabolic processes","","other molecular function","ACYP1","ENSG00000119640","Pyruvate metabolism; Metabolic pathways","","",820.4,876.4,842.1,783.2,854.7,1004.2,0.9609401612353808,-0.05748149924402365,0.6352839052111208,0.19703214728797203,0.7429264101100931,0.12905420274807428,6250]
["P07384","Calpain-1 catalytic subunit [OS=Homo sapiens]",57,35,159,34,714,81.8,5.67,466.75,"protein metabolism;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","CAPN1","ENSG00000014216","Protein processing in endoplasmic reticulum; Apoptosis; Necroptosis; Cellular senescence; Alzheimer disease; Pathways of neurodegeneration; Shigellosis","Degradation of the extracellular matrix; Neutrophil degranulation; Formation of the cornified envelope; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models","Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Alzheimer's disease",17348.1,17174.7,17296.1,15734.6,15584.8,15426,1.1085347435255661,0.14865398764007332,8.0087703323764037E-5,4.096434160427563,0.015009257015215164,1.8236408055700895,39]
["P07741-1","Adenine phosphoribosyltransferase [OS=Homo sapiens]",74,12,84,12,180,19.6,6.02,249.53,"other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","APRT","ENSG00000198931; ENSPPAG00000005769; ENSPTRG00000008466","Purine metabolism; Metabolic pathways","Neutrophil degranulation; Purine salvage","",10392.9,10120.4,10360.5,9085.2,8850.8,9965.6,1.1065243570261203,0.1460352083680616,0.04733709084057534,1.3247984356909919,0.22408471305295669,0.6495877698067362,1544]
["P07992-1","DNA excision repair protein ERCC-1 [OS=Homo sapiens]",15,3,3,3,297,32.5,6.25,10.09,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ERCC1","ENSG00000012061; ENSPPAG00000043568; ENSPTRG00000011152","Platinum drug resistance; Nucleotide excision repair; Fanconi anemia pathway","HDR through Single Strand Annealing (SSA); Fanconi Anemia Pathway; Dual incision in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER","Male infertility; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum",242.9,250.8,243.3,246.1,246.8,166.7,1.1173438447543966,0.160073220544965,0.3887455412109831,0.4103345791575719,0.5716984226782849,0.24283300600693097,4970]
["P08069","Insulin-like growth factor 1 receptor [OS=Homo sapiens]",3,4,5,3,1367,154.7,5.8,12.45,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;transporter activity;kinase activity;other molecular function","IGF1R","ENSG00000140443","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; Ras signaling pathway; Rap1 signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Oocyte meiosis; Autophagy; Endocytosis; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Focal adhesion; Adherens junction; Signaling pathways regulating pluripotency of stem cells; Long-term depression; Ovarian steroidogenesis; Progesterone-mediated oocyte maturation; Pathways in cancer; Transcriptional misregulation in cancer; Proteoglycans in cancer; Glioma; Prostate cancer; Melanoma; Breast cancer; Hepatocellular carcinoma","Extra-nuclear estrogen signaling; IRS-related events triggered by IGF1R; Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R); SHC-related events triggered by IGF1R","MicroRNAs in cardiomyocyte hypertrophy; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Apoptosis; Focal adhesion; MECP2 and associated Rett syndrome; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Ebola virus pathway in host; Ras signaling; Breast cancer pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Head and neck squamous cell carcinoma; Endochondral ossification; EGFR tyrosine kinase inhibitor resistance; Endochondral ossification with skeletal dysplasias; Insulin signaling; Malignant pleural mesothelioma; Senescence and autophagy in cancer",264.6,265.5,279,268.1,282.5,241.7,1.0212040893600909,0.030271220068510598,0.6848406656131468,0.16441045930193893,0.778581494006298,0.10869592317945712,6429]
["P08237","ATP-dependent 6-phosphofructokinase, muscle type [OS=Homo sapiens]",48,27,99,24,780,85.1,7.99,319.74,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus","kinase activity;other molecular function","PFKM","ENSG00000152556","Glycolysis / Gluconeogenesis; Pentose phosphate pathway; Fructose and mannose metabolism; Galactose metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; RNA degradation; HIF-1 signaling pathway; AMPK signaling pathway; Thyroid hormone signaling pathway; Glucagon signaling pathway; Central carbon metabolism in cancer","Glycolysis","Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Insulin signaling; Glycolysis and gluconeogenesis",10819.2,10988.5,10562.8,10073.3,9877,9264.2,1.108028547467867,0.1479950517478993,0.018311010086020343,1.7372876981513128,0.14102757926103549,0.8506959486946324,949]
["P08582-1","Melanotransferrin [OS=Homo sapiens]",10,5,7,5,738,80.2,5.94,23.52,"transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","MELTF","ENSG00000163975","","Post-translational modification: synthesis of GPI-anchored proteins; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","3q29 copy number variation syndrome",466.7,471.9,506.2,398.5,444.5,603.6,0.9987557030277893,-1.7962588428241458E-3,0.9928977512158232,0.003095472923696251,0.9949396303312932,2.203270017485767E-3,7294]
["P08670","Vimentin [OS=Homo sapiens]",82,44,1256,40,466,53.6,5.12,3152.9,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","VIM","ENSG00000026025","Epstein-Barr virus infection; MicroRNAs in cancer","Aggrephagy; Interleukin-4 and Interleukin-13 signaling; Chaperone Mediated Autophagy; Late endosomal microautophagy; Striated Muscle Contraction; RHOBTB1 GTPase cycle; Caspase-mediated cleavage of cytoskeletal proteins","Allograft Rejection; Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Mammary gland development pathway - Puberty (Stage 2 of 4); Apoptosis-related network due to altered Notch3 in ovarian cancer; Striated muscle contraction pathway; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Ciliary landscape; Burn wound healing; CCL18 signaling pathway; T-cell receptor (TCR) signaling pathway",115865,114650.6,118146.4,130907,135923,127700.4,0.8837392505114943,-0.17830733328563955,0.004196143739465201,2.377149643408088,0.07233399667865839,1.1406575381168478,424]
["P08887-1","Interleukin-6 receptor subunit alpha [OS=Homo sapiens]",2,1,1,1,468,51.5,8.22,2.3,"other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","other molecular function","IL6R","ENSG00000160712","EGFR tyrosine kinase inhibitor resistance; Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor; HIF-1 signaling pathway; PI3K-Akt signaling pathway; JAK-STAT signaling pathway; Hematopoietic cell lineage; Th17 cell differentiation; Non-alcoholic fatty liver disease; Human cytomegalovirus infection; Coronavirus disease; Pathways in cancer","Transcriptional regulation of granulopoiesis; Potential therapeutics for SARS; Interleukin-4 and Interleukin-13 signaling; Interleukin-6 signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation","Pluripotent stem cell differentiation pathway; IL-6 signaling pathway; Hepatitis C and hepatocellular carcinoma; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Nonalcoholic fatty liver disease; Regulatory circuits of the STAT3 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Neuroinflammation and glutamatergic signaling; Senescence and autophagy in cancer; Sudden infant death syndrome (SIDS) susceptibility pathways",89.2,89.7,96.2,154.7,185.5,598.3,0.29312733084709647,-1.7704006054020258,0.19698205033072952,0.705573346414442,0.44422764759867384,0.35239441556267903,3241]
["P09001","39S ribosomal protein L3, mitochondrial [OS=Homo sapiens]",47,10,38,10,348,38.6,9.48,101.96,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL3","ENSG00000114686","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",3708.7,3652.8,3480.7,3648.6,3500.9,4087.2,0.9648918276718254,-0.05156088144848935,0.5247851887061664,{"$f":"-LOG10(AA1091)","v":0.28001843078551036},0.6674186435102437,{"$f":"-LOG10(AC1091)","v":0.17560166603523497},5747]
["P09493-1","Tropomyosin alpha-1 chain [OS=Homo sapiens]",28,10,53,1,284,32.7,4.74,127.27,"cell organization and biogenesis;stress response;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","TPM1","ENSG00000140416; ENSGGOG00000009130; ENSPPAG00000004536; ENSPTRG00000007141","Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; MicroRNAs in cancer; Hypertrophic cardiomyopathy; Dilated cardiomyopathy","Smooth Muscle Contraction; Striated Muscle Contraction","Vitamin D receptor pathway; Striated muscle contraction pathway",79.7,87.3,76.2,76.2,86.4,75.3,1.0222782681799074,0.03178795701845072,0.7334679459697034,0.13461886095179817,0.8152246376357303,0.0887227035998192,6576]
["P09543-1","2',3'-cyclic-nucleotide 3'-phosphodiesterase [OS=Homo sapiens]",47,20,86,19,421,47.5,9.07,280.98,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;mitochondrion;other cell component","nucleic acid binding activity;other molecular function","CNP","ENSG00000173786; ENSPTRG00000009187","","","Glial cell differentiation; MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation",9605.9,9568.3,9798.8,7974.1,7824.9,8818.6,1.1769222020018197,0.2350189571684218,0.010241823246254021,1.9896227235063992,0.10558178576427453,0.9764109968054929,709]
["P09651-1","Heterogeneous nuclear ribonucleoprotein A1 [OS=Homo sapiens]",68,24,322,1,372,38.7,9.13,982.14,"RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HNRNPA1; HNRPA1","ENSCANG00000041992; ENSCATG00000043560; ENSG00000135486; ENSMFAG00000031561; ENSMLEG00000044414; ENSMMUG00000012989; ENSMNEG00000042992; ENSPANG00000010434; ENSPPAG00000018027; ENSPTRG00000049417; ENSRBIG00000029387; ENSRROG00000030782","Spliceosome; Amyotrophic lateral sclerosis","mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA","mRNA processing; mRNA Processing",23082.9,21257.8,24013.3,27543.6,30740.5,37046.8,0.7170183015160878,-0.47991815145595645,0.03644851666627994,1.4383201413311297,0.19836352071023092,0.7025381921158721,1343]
["P09960-1","leukotriene A-4 hydrolase [OS=Homo sapiens]",49,28,124,28,611,69.2,6.18,365.67,"protein metabolism;other metabolic processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","LTA4H","ENSG00000111144; ENSPTRG00000005321","Arachidonic acid metabolism; Metabolic pathways","Neutrophil degranulation; Biosynthesis of protectins; Synthesis of Leukotrienes (LT) and Eoxins (EX); Biosynthesis of D-series resolvins; Biosynthesis of E-series 18(S)-resolvins; Biosynthesis of aspirin-triggered D-series resolvins; Biosynthesis of E-series 18(R)-resolvins","Eicosanoid synthesis; Eicosanoid metabolism via lipooxygenases (LOX); Prostaglandin and leukotriene metabolism in senescence",17303.3,17345,17385.3,15498.6,14364.9,10633.3,1.2848817684360248,0.3616356123852323,0.05903322987623862,1.2289034546400008,0.24984011416643204,0.6023378303234865,1727]
["P0CAP2-1","DNA-directed RNA polymerase II subunit GRINL1A [OS=Homo sapiens]",22,5,6,5,368,41.7,6.39,18.32,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction","nucleus;other cell component","other molecular function","POLR2M","ENSG00000255529","RNA polymerase","","",412.8,351,347.5,453.7,443.1,391.5,0.8626096406116588,-0.2132202550207108,0.10822980474309328,0.9656531250611776,0.33676102293200033,0.4726781799548105,2349]
["P0CG08","Golgi pH regulator B [OS=Homo sapiens]",11,3,12,3,455,52.9,9.28,50.47,"transport;developmental processes;other biological processes","other membranes;ER/Golgi","transporter activity","GPR89B","ENSG00000188092","","","",459,458.6,480,365.1,387.5,180.3,1.4981241290599203,0.5831571651584806,0.07887335285735472,1.1030696971922607,0.2878109515898181,0.540892684601864,2003]
["P0DMV8","heat shock 70 kDa protein 1A [OS=Homo sapiens]",57,32,354,17,641,70,5.66,921,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","HSPA1A","ENSG00000204389; ENSG00000215328; ENSG00000234475; ENSG00000235941; ENSG00000237724","Spliceosome; MAPK signaling pathway; Protein processing in endoplasmic reticulum; Endocytosis; Longevity regulating pathway; Antigen processing and presentation; Estrogen signaling pathway; Prion disease; Legionellosis; Toxoplasmosis; Measles; Lipid and atherosclerosis","AUF1 (hnRNP D0) binds and destabilizes mRNA; Neutrophil degranulation; Regulation of HSF1-mediated heat shock response; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase; Viral RNP Complexes in the Host Cell Nucleus","Apoptosis modulation and signaling; Parkin-ubiquitin proteasomal system pathway; Nuclear receptors meta-pathway; NRF2 pathway; MAPK signaling pathway; Apoptosis modulation by HSP70; VEGFA-VEGFR2 signaling pathway",18365.9,17953.5,17811.2,17641.2,18213.1,12665.8,1.1156324904524104,0.15786185555273458,0.3501350416094698,0.45576442275089235,0.5547663167404324,0.2558899154751861,4613]
["P10114","Ras-related protein Rap-2a [OS=Homo sapiens]",50,8,41,4,183,20.6,4.82,124.75,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","RAP2A","ENSG00000125249","","","",585.2,628.2,601.3,533.1,554.3,508.7,1.136958837165591,0.18518002336642952,0.016052588744959302,1.7944549204558793,0.13168167355432944,0.880474662608781,891]
["P10412","Histone H1.4 [OS=Homo sapiens]",45,17,408,3,219,21.9,11.03,1195.29,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","H1-4","ENSG00000168298","","Formation of Senescence-Associated Heterochromatin Foci (SAHF); Apoptosis induced DNA fragmentation","Pathways affected in adenoid cystic carcinoma; Genotoxicity pathway",20801,18744.3,20423.3,19487.2,20849.3,63072.8,0.5799149592928295,-0.7860867408570629,0.3691501794334675,0.43279691614319343,0.5621080544748362,0.2501801916348077,4800]
["P10747-1","T-cell-specific surface glycoprotein CD28 [OS=Homo sapiens]",8,2,6,2,220,25.1,9.39,14.27,"developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","CD28","ENSG00000178562; ENSGGOG00000041735; ENSPPAG00000034998; ENSPTRG00000012833","Cell adhesion molecules; T cell receptor signaling pathway; Intestinal immune network for IgA production; Type I diabetes mellitus; Measles; PD-L1 expression and PD-1 checkpoint pathway in cancer; Autoimmune thyroid disease; Systemic lupus erythematosus; Rheumatoid arthritis; Allograft rejection; Graft-versus-host disease; Viral myocarditis","PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; CD28 dependent PI3K/Akt signaling; CD28 dependent Vav1 pathway; Nef mediated downregulation of CD28 cell surface expression","Allograft Rejection; T cell receptor and co-stimulatory signaling; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Control of immune tolerance by vasoactive intestinal peptide; Selective expression of chemokine receptors during T-cell polarization; Inflammatory response pathway; Cancer immunotherapy by CTLA4 blockade; Modulators of TCR signaling and T cell activation; Prostaglandin signaling; T-cell receptor (TCR) signaling pathway",769.7,818.8,786.9,745,787.5,578.1,1.1254619539467452,0.17051728755164225,0.24908679336800335,0.6036492982340613,0.49164876390136014,0.308345048399531,3703]
["P10909-1","Clusterin [OS=Homo sapiens]",14,5,10,5,449,52.5,6.27,34.37,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","CLU","ENSG00000120885","Complement and coagulation cascades","Platelet degranulation ; Regulation of Complement cascade; Antimicrobial peptides; Terminal pathway of complement","Male infertility; Complement system in neuronal development and plasticity; Complement and coagulation cascades",705.1,702.5,689.3,558.1,559.1,681.8,1.165591995553085,0.22106287515789008,0.07427651841747944,1.1291484612531155,0.2785464715820201,0.5551023384867639,1949]
["P11169","Solute carrier family 2, facilitated glucose transporter member 3 [OS=Homo sapiens]",4,2,2,2,496,53.9,7.2,4.48,"other metabolic processes;transport","plasma membrane;other membranes;other cell component","transporter activity;other molecular function","SLC2A3","ENSG00000059804","","Neutrophil degranulation; Cellular hexose transport; Vitamin C (ascorbate) metabolism; MECP2 regulates neuronal receptors and channels","Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced HIF-1 survival signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K/AKT/mTOR - VitD3 signaling; Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis",125.8,111.6,141.3,124.1,138,223.9,0.7792181069958848,-0.3599008926087239,0.33112528362230315,0.4800076567036263,0.5455804098276406,0.2631412322967758,4436]
["P11277","Spectrin beta chain, erythrocytic [OS=Homo sapiens]",9,19,54,9,2137,246.3,5.27,150.96,"cell organization and biogenesis","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity","SPTB","ENSG00000070182","","COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins","",907,938.4,920,1072.7,1069,1293.3,0.8050655021834062,-0.3128219255350196,0.040443850312567885,1.3931475056551503,0.20920318608249022,0.6794317056197359,1413]
["P11279","Lysosome-associated membrane glycoprotein 1 [OS=Homo sapiens]",19,8,56,8,417,44.9,8.75,149.71,"transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","LAMP1","ENSG00000185896","Autophagy; Lysosome; Phagosome; Tuberculosis","Neutrophil degranulation","Senescence and autophagy in cancer",6651.6,6830.8,6777.9,5392.4,5142.9,3420.5,1.4517476604709154,0.5377907091019228,0.027847535464647275,1.5552132342951204,0.17322352060519738,0.7613931390189026,1175]
["P11717","Cation-independent mannose-6-phosphate receptor [OS=Homo sapiens]",37,74,213,74,2491,274.2,5.94,668.87,"protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","IGF2R","ENSG00000197081","Lysosome; Endocytosis","Neutrophil degranulation; Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; Retrograde transport at the Trans-Golgi-Network","",21333.8,21673.2,21739.4,21247.2,20754,25221,0.9631699051801341,-0.05413777995510767,0.5921863238247578,0.22754162659215207,0.7125929932227782,0.14715845229042548,6074]
["P11908","ribose-phosphate pyrophosphokinase 2 [OS=Homo sapiens]",54,16,99,7,318,34.7,6.61,304.64,"other metabolic processes","other cell component","kinase activity;other molecular function","PRPS2","ENSG00000101911","Pentose phosphate pathway; Purine metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids","5-Phosphoribose 1-diphosphate biosynthesis","Nucleotide metabolism",7000.5,7022,6756,5733.5,5548.9,3222.2,1.4325455372778293,0.5185809996179367,0.061740435757886215,1.2094303096356276,0.25365983415086585,0.5957482958355798,1779]
["P12259","Coagulation factor V [OS=Homo sapiens]",2,4,10,4,2224,251.5,6.05,25.4,"stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","F5","ENSG00000198734","Complement and coagulation cascades","COPII-mediated vesicle transport; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Common Pathway of Fibrin Clot Formation; Cargo concentration in the ER","Blood clotting cascade; Complement and coagulation cascades",1264.8,1260.1,1225.5,849.8,919,901.3,1.404591588330025,0.490150700449677,1.1826004749941591E-4,3.927161950901516,0.01571568522133147,1.8036666785117867,55]
["P12956","X-ray repair cross-complementing protein 6 [OS=Homo sapiens]",67,39,511,39,609,69.8,6.64,1565.56,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","XRCC6","ENSG00000196419","Non-homologous end-joining","Neutrophil degranulation; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation; IRF3-mediated induction of type I IFN","Non-homologous end joining; DNA repair pathways, full network",53713.6,53286.2,53742.6,51563.2,50782.5,39669.3,1.1318691687497797,0.1787072086078491,0.17970644017750353,0.7454363587094206,0.42261080156286146,0.3740594069543243,3108]
["P13073","Cytochrome c oxidase subunit 4 isoform 1, mitochondrial [OS=Homo sapiens]",36,7,70,7,169,19.6,9.51,154.87,"other metabolic processes;transport;other biological processes","other membranes;cytosol;mitochondrion;nucleus","transporter activity","COX4I1","ENSG00000131143","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly",8033.2,8925.3,8492.8,8249.7,9117.7,8181.7,0.9961720765115013,-0.005533123189236496,0.9384053490628881,0.02760952533639471,0.9596760453757729,0.017875345553588832,7147]
["P13598","Intercellular adhesion molecule 2 [OS=Homo sapiens]",8,2,2,2,275,30.6,7.43,7.3,"cell adhesion","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding","ICAM2","ENSG00000108622","Cell adhesion molecules; Natural killer cell mediated cytotoxicity","Integrin cell surface interactions; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; CD209 (DC-SIGN) signaling","Complement system; Ebola virus pathway in host",376.5,389.9,383.6,396.1,407.2,325.5,1.018781006378455,0.026843968121835805,0.7982976880518087,0.09783512848642822,0.864408563254914,0.06328093943348019,6750]
["P13747","HLA class I histocompatibility antigen, alpha chain E [OS=Homo sapiens]",38,11,40,9,358,40.1,5.95,128.11,"other biological processes","plasma membrane;other membranes","","HLA-E","","","","",1581.7,1500.4,1638.5,1898.5,1966.6,1759.2,0.8393222267659977,-0.2527033084056481,0.01454624393577476,1.8372491337264556,0.12552360912228774,0.9012745821731897,847]
["P13796","Plastin-2 [OS=Homo sapiens]",79,45,1261,36,627,70.2,5.43,3790.82,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","LCP1","ENSG00000136167","","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","",141584.5,140164.5,142196.2,137380.8,136450.6,145636.5,1.010673760733539,0.015317379310781212,0.6428782508644333,0.1918712665535443,0.7482161043898317,0.12597294840676748,6280]
["P13995","Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [OS=Homo sapiens]",38,9,47,9,350,37.9,8.73,177.98,"other metabolic processes","mitochondrion","other molecular function","MTHFD2","ENSG00000065911","One carbon pool by folate; Metabolic pathways; Biosynthesis of cofactors","Metabolism of folate and pterines","Folate metabolism; One-carbon metabolism; Trans-sulfuration and one-carbon metabolism; Nucleotide metabolism",4527.9,4470.7,4501.2,4830.6,5119,3691.1,0.9896706180767848,-0.014979647206219074,0.9194470019170711,0.036473298985243235,0.9495885455718345,0.02246453270652816,7077]
["P14174","Macrophage Migration inhibitory factor [OS=Homo sapiens]",32,3,25,3,115,12.5,7.88,55.83,"cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","MIF","ENSG00000240972; ENSG00000276701","Tyrosine metabolism; Phenylalanine metabolism; Metabolic pathways","Neutrophil degranulation; Cell surface interactions at the vascular wall; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","Adipogenesis; Spinal cord injury",2933.3,3692.5,2477.5,3106.4,3011.1,2404.9,1.0681615507368816,0.095129859404877,0.66649803273903,0.1762011281283585,0.764506296498677,0.11661893337347948,6372]
["P14373","Zinc finger protein RFP [OS=Homo sapiens]",13,5,6,5,513,58.5,6.21,17.27,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","TRIM27","ENSG00000204713; ENSG00000215641; ENSG00000229006; ENSG00000234495; ENSG00000237071","","Regulation of PTEN stability and activity; SUMOylation of ubiquitinylation proteins; Suppression of apoptosis","",362.4,375.6,357.1,445,486.3,537,0.7458285091602533,-0.42308414996404436,0.010190414346850276,1.9918081570247586,0.10579792395046686,0.9755228542828979,704]
["P14678-1","Small nuclear ribonucleoprotein-associated proteins B and B' [OS=Homo sapiens]",22,7,33,7,240,24.6,11.19,98.36,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","Snrpb; SNRPB; SNRPN","ENSANAG00000024443; ENSCANG00000019461; ENSCCAG00000026002; ENSG00000125835; ENSLCNG00005019999; ENSMLEG00000022346; ENSMMUG00000010050; ENSNLEG00000029067; ENSOGAG00000016149; ENSPANG00000020362; ENSRROG00000036094; ENSSBOG00000027310","Spliceosome; Systemic lupus erythematosus","snRNP Assembly; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs","mRNA processing",4320.6,4619.6,3814.1,4194.5,3615.8,2313.5,1.2598332641893362,0.33323280924542326,0.22013428399655624,0.657312314597863,0.46569073277303313,0.3319024044241073,3455]
["P14927","Cytochrome b-c1 complex subunit 7 [OS=Homo sapiens]",22,2,4,2,111,13.5,8.78,11.24,"other metabolic processes","other membranes;mitochondrion","","UQCRB","ENSG00000156467","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly",173.1,190.4,164.7,158.4,140.6,164.2,1.1403281519861832,0.1894490481778565,0.10504192043924976,0.9786373468143807,0.33467802811267505,0.4753727984956566,2294]
["P15121","aldose reductase [OS=Homo sapiens]",72,18,128,16,316,35.8,6.98,425.69,"other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","AKR1B1","ENSG00000085662","Pentose and glucuronate interconversions; Fructose and mannose metabolism; Galactose metabolism; Glycerolipid metabolism; Folate biosynthesis; Metabolic pathways","Pregnenolone biosynthesis; Fructose biosynthesis","Eicosanoid metabolism via cyclooxygenases (COX); Polyol pathway; Metapathway biotransformation Phase I and II",19191.8,20101.2,18187.2,17357.7,15029.1,12368.3,1.284327372746346,0.3610129897175924,0.051496481705419477,1.2882224414076888,0.23320184930911458,0.6322680099097676,1614]
["P15374","Ubiquitin carboxyl-terminal hydrolase isozyme L3 [OS=Homo sapiens]",45,9,42,9,230,26.2,4.92,127.2,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","UCHL3","ENSG00000118939","","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; UCH proteinases; Neddylation","Proteasome degradation",4208.4,4488.7,4312.6,4776.4,5126.4,5348.8,0.8530055862991425,-0.22937290516128853,0.015780003917797655,1.8018928933016498,0.13106369163088985,0.8825176035678454,880]
["P15498-1","Proto-oncogene vav [OS=Homo sapiens]",45,38,162,36,845,98.3,6.62,478.58,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","enzyme regulator activity;other molecular function","VAV1","ENSG00000141968; ENSPTRG00000010378","Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Focal adhesion; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Yersinia infection; Proteoglycans in cancer; Lipid and atherosclerosis","RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC1 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated phagocytosis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; NRAGE signals death through JNK; G alpha (12/13) signalling events; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Regulation of signaling by CBL; GPVI-mediated activation cascade; Signaling by SCF-KIT; VEGFR2 mediated vascular permeability; Erythropoietin activates RAS; CD28 dependent Vav1 pathway","Prolactin signaling pathway; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL-6 signaling pathway; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; EGF/EGFR signaling pathway; Modulators of TCR signaling and T cell activation; Regulation of actin cytoskeleton; Interferon type I signaling pathways; T-cell receptor (TCR) signaling pathway; EGFR1 signaling pathway; Kit receptor signaling pathway",23020.8,23237.4,22359.5,21633.1,20300.9,16884.7,1.1665966775872298,0.2223058705421719,0.08566688929753821,1.0671870027436203,0.3003066157677251,0.5224351001694236,2085]
["P15924-1","Desmoplakin [OS=Homo sapiens]",30,80,151,80,2871,331.6,6.81,424.21,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","DSP","ENSG00000096696","Arrhythmogenic right ventricular cardiomyopathy","Neutrophil degranulation; Formation of the cornified envelope; RND3 GTPase cycle; RND1 GTPase cycle; Apoptotic cleavage of cell adhesion  proteins","Arrhythmogenic right ventricular cardiomyopathy; Lung fibrosis; Epithelial to mesenchymal transition in colorectal cancer",16443.2,15545.2,16396.6,15221.4,15465.3,16655.7,{"$f":"AVERAGE(S1282:U1282)/AVERAGE(V1282:X1282)","v":1.0220225421609384},{"$f":"LOG(Y1282,2)","v":0.03142701731774611},{"$f":"TTEST(V1282:X1282,S1282:U1282,2,2)","v":0.5482169146081481},0.26104756892848663,{"$f":"AA1282*7309/AE1282","v":0.6834244292803948},0.16530950122931098,5863]
["P16035","Metalloproteinase inhibitor 2 [OS=Homo sapiens]",10,2,3,2,220,24.4,7.49,10.74,"developmental processes;other biological processes","non-structural extracellular;extracellular matrix;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","TIMP2","ENSG00000035862","","Neutrophil degranulation; Activation of Matrix Metalloproteinases","Matrix metalloproteinases; Angiogenesis; IL1 and megakaryocytes in obesity; Vitamin D receptor pathway; Burn wound healing; CCL18 signaling pathway",179.5,194.6,190.6,240.2,230.6,427.5,0.6286318601803407,-0.6697127025480611,0.158556546027082,0.7998158233640796,0.3976972528867338,0.40044740891407804,2914]
["P16219","Short-chain specific acyl-CoA dehydrogenase, mitochondrial [OS=Homo sapiens]",6,2,5,2,412,44.3,7.99,12.11,"other metabolic processes","cytoskeleton;mitochondrion;nucleus","other molecular function","ACADS","ENSG00000122971","Fatty acid degradation; Valine, leucine and isoleucine degradation; beta-Alanine metabolism; Propanoate metabolism; Butanoate metabolism; Metabolic pathways; Carbon metabolism; Fatty acid metabolism","Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA","Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation; IL-18 signaling pathway",173.4,199,215.1,164.7,150.3,395.4,0.8269988738738739,-0.27404273001038143,0.6369237597125652,0.19591254995310087,0.743891939875222,0.12849014687930244,6258]
["P16402","Histone H1.3 [OS=Homo sapiens]",47,17,377,5,221,22.3,11.02,1091.22,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity","H1-3","ENSG00000124575","","Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)","",12841.6,12182.3,12599.6,11628.8,12293.5,17280.9,0.9131208255669462,-0.13112232239642155,0.5423515995132175,0.26571907467609335,0.6802896586308748,0.1673061308822704,5827]
["P16619","C-C motif chemokine 3-like 1 [OS=Homo sapiens]",24,2,10,2,93,10.2,4.89,30.53,"stress response;signal transduction;other biological processes","non-structural extracellular","signal transduction activity or receptor binding","CCL3L1; CCL3L3","ENSG00000276085; ENSG00000277336; ENSG00000277768; ENSG00000277796","Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor; Chemokine signaling pathway; Toll-like receptor signaling pathway; Chagas disease; Human cytomegalovirus infection; Rheumatoid arthritis; Lipid and atherosclerosis","Chemokine receptors bind chemokines; Interleukin-10 signaling","Overview of proinflammatory and profibrotic mediators",911.2,1043.4,879.6,1691.6,2014.3,2191.2,0.48060911295382486,-1.057064090846037,0.002725980578808096,2.5644772426123215,0.057919162937524346,1.2371777232998789,344]
["P16949-1","Stathmin [OS=Homo sapiens]",36,6,9,6,149,17.3,5.97,21.91,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity","LOC101348598; Stathmin; STMN1","ENSAMEG00000010298; ENSANAG00000030242; ENSBIXG00000025259; ENSBTAG00000013761; ENSCAFG00000029191; ENSCATG00000016402; ENSCCAG00000028161; ENSCHIG00000023552; ENSCJAG00000009462; ENSCSAG00000000960; ENSFCAG00000040721; ENSG00000117632; ENSGGOG00000026648; ENSLCNG00005009740; ENSMFAG00000041588; ENSMLEG00000037590; ENSMLUG00000010762; ENSMMUG00000000653; ENSMNEG00000044643; ENSNLEG00000009154; ENSOARG00000005764; ENSOGAG00000002109; ENSPANG00000010315; ENSPCTG00005008718; ENSPPAG00000038785; ENSPPYG00000001700; ENSPTRG00000000369; ENSRBIG00000033291; ENSRFEG00010003199; ENSRROG00000019821; ENSSBOG00000029102; ENSSSCG00000026257; ENSSSCG00005028094; ENSSSCG00015059883; ENSSSCG00055018660; ENSSSCG00070026240; ENSSSUG00005019081; ENSTTRG00000012495; ENSUAMG00000025721; ENSUMAG00000012809; ENSVVUG00000011613","MAPK signaling pathway; MicroRNAs in cancer","Nuclear signaling by ERBB4","MAPK signaling pathway; Microtubule cytoskeleton regulation; Retinoblastoma gene in cancer; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; EGF/EGFR signaling pathway; IL-18 signaling pathway; MAPK signaling pathway; MAPK signaling pathway",905.5,814.1,1245.2,907.4,893.1,1262.4,0.9679715302491104,-0.04696347897058654,0.8634031889177328,0.06378635164127881,0.9106224975179956,0.04066162436911256,6930]
["P17096-1","High mobility group protein HMG-I/HMG-Y [OS=Homo sapiens]",48,4,8,4,107,11.7,10.32,24.83,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","HMGA1; LOC111152215","ENSAMEG00000001061; ENSCAFG00030004107; ENSCAFG00040011381; ENSCANG00000029050; ENSCATG00000042051; ENSCCAG00000024304; ENSCSAG00000009775; ENSECAG00000000734; ENSFCAG00000044104; ENSG00000137309; ENSGGOG00000025804; ENSMLEG00000042857; ENSMMUG00000019529; ENSMNEG00000005671; ENSPCTG00005015441; ENSPTRG00000040884; ENSRBIG00000030072; ENSRFEG00010017624; ENSUAMG00000015725; ENSUMAG00000010910","","Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Formation of Senescence-Associated Heterochromatin Foci (SAHF)","Adipogenesis; Adipogenesis; Pre-implantation embryo; Male infertility; 7q11.23 copy number variation syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Orexin receptor pathway; Senescence and autophagy in cancer; Adipogenesis",1096.4,1063,1146.7,762.8,836.2,978.3,1.2827765491017733,0.3592698847077367,0.023071933214977473,1.6369160140865637,0.15643113160321925,0.8056768130533106,1078]
["P17152","Transmembrane protein 11, mitochondrial [OS=Homo sapiens]",14,3,9,3,192,21.5,7.36,21.08,"cell organization and biogenesis","plasma membrane;other membranes;mitochondrion","","TMEM11","ENSG00000178307","","Cristae formation","",1382.1,1314.1,1417.1,1303.4,1190.6,847.1,1.23112148693544,0.29997313383801977,0.14092044477510962,0.8510259947622189,0.3795090386371688,0.4207778762019642,2714]
["P17612","cAMP-dependent protein kinase catalytic subunit alpha [OS=Homo sapiens]",37,15,43,9,351,40.6,8.79,135.85,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","kinase activity;other molecular function","PRKACA","ENSG00000072062; ENSG00000288516","Endocrine resistance; MAPK signaling pathway; Ras signaling pathway; Calcium signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Oocyte meiosis; Autophagy; Longevity regulating pathway; Longevity regulating pathway; Adrenergic signaling in cardiomyocytes; Vascular smooth muscle contraction; Wnt signaling pathway; Hedgehog signaling pathway; Apelin signaling pathway; Tight junction; Gap junction; Platelet activation; Circadian entrainment; Thermogenesis; Long-term potentiation; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; GABAergic synapse; Dopaminergic synapse; Olfactory transduction; Taste transduction; Inflammatory mediator regulation of TRP channels; Insulin signaling pathway; Insulin secretion; GnRH signaling pathway; Ovarian steroidogenesis; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Melanogenesis; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Regulation of lipolysis in adipocytes; Renin secretion; Aldosterone synthesis and secretion; Relaxin signaling pathway; Cortisol synthesis and secretion; Parathyroid hormone synthesis, secretion and action; Cushing syndrome; Growth hormone synthesis, secretion and action; Endocrine and other factor-regulated calcium reabsorption; Vasopressin-regulated water reabsorption; Salivary secretion; Gastric acid secretion; Bile secretion; Parkinson disease; Prion disease; Cocaine addiction; Amphetamine addiction; Morphine addiction; Alcoholism; Vibrio cholerae infection; Amoebiasis; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; Chemical carcinogenesis; Dilated cardiomyopathy","Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; MAPK6/MAPK4 signaling; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Interleukin-3, Interleukin-5 and GM-CSF signaling; Factors involved in megakaryocyte development and platelet production; VEGFA-VEGFR2 Pathway; RET signaling; ROBO receptors bind AKAP5; FCGR3A-mediated IL10 synthesis; Triglyceride catabolism; ADORA2B mediated anti-inflammatory cytokines production; Ion homeostasis; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; Regulation of MECP2 expression and activity; PKA activation; PKA activation in glucagon signalling; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; CD209 (DC-SIGN) signaling; Rap1 signalling; HDL assembly; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase; Loss of phosphorylation of MECP2 at T308; PKA-mediated phosphorylation of key metabolic factors","Nicotine effect on dopaminergic neurons; Sterol regulatory element-binding proteins (SREBP) signaling; Follicle stimulating hormone (FSH) signaling pathway; Microtubule cytoskeleton regulation; Dopamine metabolism; Common pathways underlying drug addiction; Complement system; Mesodermal commitment pathway; IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Mesodermal commitment pathway; G protein signaling pathways; MAPK signaling pathway; Cannabinoid receptor signaling; Lipid metabolism pathway; Ras signaling; Hedgehog signaling pathway; Thermogenesis; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Neuroinflammation and glutamatergic signaling; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways; Estrogen signaling pathway",5867.2,6053.5,5747.9,5135,5190.1,3977.9,1.2353072781933858,0.30486995159576846,0.05035855304062592,1.29792675702922,0.2303320802089705,0.6376455701232195,1598]
["P17931","Galectin-3 [OS=Homo sapiens]",6,1,1,1,250,26.1,8.56,3.66,"RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","LGALS3","ENSG00000131981","","Neutrophil degranulation; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; Advanced glycosylation endproduct receptor signaling; RUNX2 regulates genes involved in differentiation of myeloid cells","AGE/RAGE pathway; Spinal cord injury",74,80.8,87.6,87.1,78.4,143.9,0.7834518422753717,-0.3520834979760848,0.34564880423800604,0.4613649412080889,0.5520863440069026,0.2579929951090837,4576]
["P18031","Tyrosine-protein phosphatase non-receptor type 1 [OS=Homo sapiens]",46,18,62,18,435,49.9,6.27,198.79,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","PTPN1","ENSG00000196396","Adherens junction; Insulin signaling pathway; Insulin resistance; Chemical carcinogenesis","MECP2 regulates neuronal receptors and channels; Growth hormone receptor signaling; Regulation of IFNG signaling; Regulation of IFNA signaling; Negative regulation of MET activity; Integrin signaling; PTK6 Down-Regulation","Leptin signaling pathway; Prolactin signaling pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Insulin signaling",7963.2,7882.5,8184.2,7986.6,8039.4,9097.7,0.9564634190027742,-0.0642183027221418,0.3836258397435616,0.41609214790363125,0.570134457642475,0.24402271042235665,4918]
["P18583-5","Isoform D of Protein SON [OS=Homo sapiens]",24,37,125,6,2459,266.9,5.73,394.66,"","","","SON","","","","",11743,11453.8,11881.6,15412.3,15806,14191.3,0.7724886367640323,-0.372414383624076,0.002367091765347833,2.625784905395088,0.0547502332687573,1.2616140261295192,316]
["P18827","syndecan-1 [OS=Homo sapiens]",16,5,34,5,310,32.4,4.63,131.88,"cell-cell signaling;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SDC1","ENSG00000115884","ECM-receptor interaction; Cell adhesion molecules; Malaria; Proteoglycans in cancer; Fluid shear stress and atherosclerosis","Cell surface interactions at the vascular wall; A tetrasaccharide linker sequence is required for GAG synthesis; HS-GAG biosynthesis; HS-GAG degradation; Defective B4GALT7 causes EDS, progeroid type; Defective B3GAT3 causes JDSSDHD; Defective EXT2 causes exostoses 2; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Defective B3GALT6 causes EDSP2 and SEMDJL1; Retinoid metabolism and transport; Syndecan interactions; Other interleukin signaling","",3912.7,4205.4,4008.1,4475.8,5044,2149.4,1.039162924622082,0.055421864172071025,0.8723607267474114,0.05930389437808032,0.9174222376686086,0.037430737084221226,6950]
["P18850","Cyclic AMP-dependent transcription factor ATF-6 alpha [OS=Homo sapiens]",2,1,1,1,670,74.5,8.22,0,"stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","ATF6","ENSG00000118217","Protein processing in endoplasmic reticulum; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Lipid and atherosclerosis","ATF4 activates genes in response to endoplasmic reticulum  stress; ATF6 (ATF6-alpha) activates chaperone genes","Sterol regulatory element-binding proteins (SREBP) signaling; Alzheimer's disease and miRNA effects; Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling pathway; Unfolded protein response; Alzheimer's disease",24.1,26.9,26.7,36.4,37.6,85,0.4886792452830189,-1.0330402617640075,0.16616214035311844,0.7794679222411214,0.4090532448100177,0.3882201579531931,2969]
["P19388","DNA-directed RNA polymerases I, II, and III subunit RPABC1 [OS=Homo sapiens]",21,4,11,4,210,24.5,5.95,29.4,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR2E","ENSG00000099817","RNA polymerase; Cytosolic DNA-sensing pathway; Huntington disease","mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; RNA Polymerase I Promoter Escape; Inhibition of DNA recombination at telomere; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Viral Messenger RNA Synthesis; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM","Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway",1187.5,1419.6,1101.7,1571.6,1482.2,1502.5,0.8139938107675088,-0.29691026994002745,0.045873002549171996,1.3384428328381346,0.22087336998148754,0.6558566425136232,1518]
["P19397","Leukocyte surface antigen CD53 [OS=Homo sapiens]",13,4,10,4,219,24.3,7.52,23.32,"signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","CD53","ENSG00000143119","","Neutrophil degranulation","",1103.1,1156.7,1254.5,1157.8,981.6,2309.8,0.7898723365998381,-0.34030859886033304,0.4981809892680113,0.3026128492875255,0.6480165243922218,0.18841391949845243,5619]
["P19784","casein kinase II subunit alpha' [OS=Homo sapiens]",51,14,25,13,350,41.2,8.56,89.99,"cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","CSNK2A2","ENSG00000070770","Ribosome biogenesis in eukaryotes; NF-kappa B signaling pathway; Mitophagy; Wnt signaling pathway; Adherens junction; Alzheimer disease; Prion disease; Pathways of neurodegeneration; Measles; PD-L1 expression and PD-1 checkpoint pathway in cancer","ROS sensing by NFE2L2; Regulation of PTEN stability and activity; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of TP53 Activity through Phosphorylation; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Receptor Mediated Mitophagy; Condensation of Prometaphase Chromosomes; Synthesis of PC","Alzheimer's disease and miRNA effects; Allograft Rejection; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Malignant pleural mesothelioma; Alzheimer's disease",2099.5,2103.7,2173.4,1917.2,1925.8,2333.4,1.0324137037756622,0.04602119632946571,0.65712655852289,0.18235097994561134,0.7573222983670456,0.12071925575270831,6342]
["P20036","HLA class II histocompatibility antigen, DP alpha 1 chain [OS=Homo sapiens]",18,3,4,3,260,29.4,5.21,16,"stress response;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","HLA-DPA1","ENSG00000168384; ENSG00000206291; ENSG00000224103; ENSG00000228163; ENSG00000229685; ENSG00000231389; ENSG00000235844; ENSG00000236177","Phagosome; Cell adhesion molecules; Antigen processing and presentation; Hematopoietic cell lineage; Th1 and Th2 cell differentiation; Th17 cell differentiation; Intestinal immune network for IgA production; Type I diabetes mellitus; Leishmaniasis; Toxoplasmosis; Staphylococcus aureus infection; Tuberculosis; Influenza A; Human T-cell leukemia virus 1 infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Asthma; Autoimmune thyroid disease; Inflammatory bowel disease; Systemic lupus erythematosus; Rheumatoid arthritis; Allograft rejection; Graft-versus-host disease; Viral myocarditis","Downstream TCR signaling; Generation of second messenger molecules; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling","Allograft Rejection; Ebola virus pathway in host",343.7,355.2,350.5,298.3,325,639.9,0.8307473084230527,-0.267518381217428,0.551472302221391,0.25847629518115195,0.6860784777763654,0.16362620424095284,5875]
["P20073-1","Annexin A7 [OS=Homo sapiens]",34,16,117,16,488,52.7,5.68,287.16,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ANXA7","ENSG00000138279","Amyotrophic lateral sclerosis","","",10850.7,10445.3,11249.9,11141.7,9707.5,10186.5,1.04866009144308,0.06854712419118415,0.354646163875913,0.4502047334512412,0.5566048554367722,0.2544530094999996,4657]
["P20340-2","Isoform 2 of Ras-related protein Rab-6A [OS=Homo sapiens]",45,11,48,1,208,23.5,5.54,102.09,"","","","RAB6A","","","","",186.5,188.3,211.9,178.9,162.4,257,0.9806117332441922,-0.028246070983590204,0.9046159404563126,0.04353576371455233,0.9395819111546381,0.02706535285797479,7037]
["P20701-1","Integrin alpha-L [OS=Homo sapiens]",11,8,11,8,1170,128.7,5.63,35.18,"cell adhesion;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","ITGAL","ENSG00000005844","Rap1 signaling pathway; Cell adhesion molecules; Neutrophil extracellular trap formation; Natural killer cell mediated cytotoxicity; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Malaria; Staphylococcus aureus infection; Human T-cell leukemia virus 1 infection; Epstein-Barr virus infection; Rheumatoid arthritis; Viral myocarditis","Neutrophil degranulation; Integrin cell surface interactions; Cell surface interactions at the vascular wall; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; RUNX3 Regulates Immune Response and Cell Migration","Integrin-mediated cell adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Acute viral myocarditis; Cells and molecules involved in local acute inflammatory response ; Overview of leukocyte-intrinsic Hippo pathway functions; CCL18 signaling pathway",1395.8,1394.7,1465.9,1152.1,1154.8,626.2,1.4511608877978932,0.5372074774754686,0.06766136908893221,1.1696592187597898,0.26545193058024985,0.5760141117720596,1863]
["P20810-6","Isoform 6 of Calpastatin [OS=Homo sapiens]",65,41,192,1,791,84.9,5.36,471.87,"","","","CAST","","","","",18438.2,17653.4,17718.1,21697.8,22478.2,21107.5,0.8242465554083345,-0.2788521421159918,1.2400237215850476E-3,2.906570006728936,0.04119696991393233,1.3851347256671693,220]
["P21333-2","Isoform 2 of Filamin-A [OS=Homo sapiens]",58,114,509,103,2639,279.8,6.05,1811.48,"","","","FLNA","","","","",58083.5,57470.5,60202.4,48158.1,49246.1,54612.5,1.1561650792314264,0.20934740301622945,0.021508791925287412,1.6673839817517893,0.15116130786723625,0.8205593591665966,1040]
["P21359-1","Neurofibromin [OS=Homo sapiens]",3,6,6,6,2839,319.2,7.39,17.78,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","NF1","ENSG00000196712","EGFR tyrosine kinase inhibitor resistance; MAPK signaling pathway; Ras signaling pathway","Regulation of RAS by GAPs; RAS signaling downstream of NF1 loss-of-function variants","Pilocytic astrocytoma; Glioblastoma signaling pathways; Aryl hydrocarbon receptor Netpath; MECP2 and associated Rett syndrome; MAPK signaling pathway; Ras signaling; Transcription co-factors SKI and SKIL protein partners; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Melanoma; EGFR tyrosine kinase inhibitor resistance",263.6,316,298.5,286.4,312.5,522.7,0.7828994293865906,-0.3531011028807164,0.347755056527101,0.4587265464377079,0.5535151803476874,0.2568704639436521,4592]
["P21964-1","Catechol O-methyltransferase [OS=Homo sapiens]",44,9,29,9,271,30,5.47,77.17,"other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","COMT","ENSG00000093010","Steroid hormone biosynthesis; Tyrosine metabolism; Metabolic pathways; Dopaminergic synapse","Potential therapeutics for SARS; Methylation; Enzymatic degradation of dopamine by COMT; Enzymatic degradation of Dopamine by monoamine oxidase","Dopamine metabolism; MTHFR deficiency; 22q11.2 copy number variation syndrome; Biogenic amine synthesis; Estrogen metabolism; Metapathway biotransformation Phase I and II; Methylation pathways",3277.8,3161.9,3549.3,3229.1,3047.8,2946,1.083064979561743,0.1151198014681668,0.14552450530038577,0.8370638683920104,0.3824662384899387,0.417406895372197,2781]
["P22304","iduronate 2-sulfatase [OS=Homo sapiens]",9,3,6,3,550,61.8,5.45,24.23,"other metabolic processes","other cytoplasmic organelle","other molecular function","IDS","ENSG00000010404","Glycosaminoglycan degradation; Metabolic pathways; Lysosome","HS-GAG degradation; CS/DS degradation; MPS II - Hunter syndrome","Glycosaminoglycan degradation",234.6,231.1,224.7,212.4,249.1,432.3,0.7724323114790781,-0.372519580216055,0.3756404945874065,0.42522759631036117,0.5649292952550111,0.2480059036886816,4860]
["P22392-2","Isoform 3 of Nucleoside diphosphate kinase B [OS=Homo sapiens]",81,15,248,2,267,30.1,8.92,730.63,"","","","NME2","","","","",39357,38454.6,40350,42051.2,38268.9,30943.6,1.0619959609468317,0.08677827919945184,0.5250407443139191,0.2798069930814724,0.6676274878549817,0.17546579065968745,5748]
["P22695","Cytochrome b-c1 complex subunit 2, mitochondrial [OS=Homo sapiens]",48,17,119,17,453,48.4,8.63,367.02,"protein metabolism;other metabolic processes;other biological processes","other membranes;mitochondrion;nucleus","other molecular function","UQCRC2","ENSG00000140740","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly",13788.5,13460.3,14292.2,12580.4,11553.9,12864,1.1227813169794287,0.16707696279511858,0.031333166781605394,1.5039957096100267,0.18394708112992275,0.7353070991578089,1245]
["P23229-1","integrin alpha-6 [OS=Homo sapiens]",2,2,2,2,1130,126.5,6.61,6.6,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","ITGA6","ENSG00000091409","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Cell adhesion molecules; Hematopoietic cell lineage; Regulation of actin cytoskeleton; Toxoplasmosis; Human papillomavirus infection; Pathways in cancer; Small cell lung cancer; Hypertrophic cardiomyopathy; Arrhythmogenic right ventricular cardiomyopathy; Dilated cardiomyopathy","Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; Syndecan interactions; Laminin interactions; Basigin interactions; Type I hemidesmosome assembly","Integrin-mediated cell adhesion; Arrhythmogenic right ventricular cardiomyopathy; Alpha 6 beta 4 signaling pathway; Mammary gland development pathway - Embryonic development (Stage 1 of 4); Focal adhesion; Regulation of apoptosis by parathyroid hormone-related protein; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ebola virus pathway in host; Small cell lung cancer; Malignant pleural mesothelioma",116.7,106.1,133.5,127.8,131.9,155.5,0.858140655105973,-0.2207139602245814,0.17014392206886658,0.7691835602860594,0.41246498388104336,0.38461291487825655,3015]
["P23284","peptidyl-prolyl cis-trans isomerase B [OS=Homo sapiens]",64,18,453,16,216,23.7,9.41,1131.48,"protein metabolism;other metabolic processes;developmental processes;other biological processes","ER/Golgi;nucleus;other cell component","other molecular function","PPIB","ENSG00000166794","","Collagen biosynthesis and modifying enzymes","Prolactin signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta",72245,72223.1,73302.7,68583.8,66200.7,65807.1,1.085642668985142,0.11854932918879994,3.6397211714498355E-3,2.4389318851253767,0.06667348882738558,1.1760468189281519,399]
["P23434","Glycine cleavage system H protein, mitochondrial [OS=Homo sapiens]",39,3,11,3,173,18.9,4.88,37.11,"protein metabolism;other metabolic processes","mitochondrion;other cell component","other molecular function","GCSH","ENSG00000140905","Glycine, serine and threonine metabolism; Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism","Glycine degradation","",944.6,1000.2,942.2,931.4,933.5,597,1.1726715138714001,0.22979894544043325,0.2796282559506747,0.5534189460041958,0.5140349403278374,0.2890073598454986,3976]
["P23468-1","Receptor-type tyrosine-protein phosphatase delta [OS=Homo sapiens]",2,2,2,2,1912,214.6,6.57,8.19,"cell adhesion;cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","PTPRD","ENSG00000153707; ENSG00000282932","","Synaptic adhesion-like molecules; Receptor-type tyrosine-protein phosphatases","",40.7,33.2,42.9,32.4,41.1,51,0.9381526104417671,-0.09210546807542598,0.6966135195500778,0.15700810121137299,0.7865824524009761,0.10425574634533041,6473]
["P23634-1","Plasma membrane calcium-transporting ATPase 4 [OS=Homo sapiens]",21,20,33,10,1241,137.8,6.6,122.21,"stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","transporter activity;enzyme regulator activity;other molecular function","ATP2B4","ENSG00000058668","Calcium signaling pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Adrenergic signaling in cardiomyocytes; Aldosterone synthesis and secretion; Endocrine and other factor-regulated calcium reabsorption; Salivary secretion; Pancreatic secretion; Mineral absorption","Ion homeostasis; Ion transport by P-type ATPases; Reduction of cytosolic Ca++ levels","Vitamin D-sensitive calcium signaling in depression",874.8,922.2,911.8,769.9,845.3,698.4,1.170816044260028,0.2275144209445243,0.04232476319340103,1.373405463085227,0.21438093844807216,0.6688138322947484,1443]
["P24539","ATP synthase F(0) complex subunit B1, mitochondrial [OS=Homo sapiens]",43,12,65,12,256,28.9,9.36,184.57,"other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","ATP5PB","ENSG00000116459","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation",8207.8,7699.5,7994.6,6015.5,6791.4,6791.5,1.2195842517756552,0.28638942637547377,0.008530232512871001,2.069039130886332,0.09651311058293212,1.0154136869974433,646]
["P24752","Acetyl-CoA acetyltransferase, mitochondrial [OS=Homo sapiens]",64,25,217,25,427,45.2,8.85,726.81,"other metabolic processes;stress response;developmental processes;other biological processes","mitochondrion","other molecular function","ACAT1","ENSG00000075239","Fatty acid degradation; Valine, leucine and isoleucine degradation; Lysine degradation; Tryptophan metabolism; Pyruvate metabolism; Glyoxylate and dicarboxylate metabolism; Butanoate metabolism; Terpenoid backbone biosynthesis; Metabolic pathways; Carbon metabolism; Fatty acid metabolism; Fat digestion and absorption","Branched-chain amino acid catabolism; Utilization of Ketone Bodies; Synthesis of Ketone Bodies","Fatty acid beta-oxidation; Ketone bodies synthesis and degradation; Tryptophan metabolism; SARS-CoV-2 and COVID-19 pathway",27102.5,26850.3,27661.4,25531.4,24854.7,34794.1,0.958135810904412,-0.061697929707398444,0.7303495004941681,0.13646926342409796,0.8124999237613203,0.0901766710999058,6570]
["P25440-1","Bromodomain-containing protein 2 [OS=Homo sapiens]",3,2,2,2,801,88,9.09,5.99,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","kinase activity;other molecular function","BRD2","ENSG00000204256; ENSG00000215077; ENSG00000234507; ENSG00000234704; ENSG00000235307; ENSGGOG00000043461","","RUNX3 regulates p14-ARF","",136.9,146.8,125.6,679.3,697.2,375.8,0.23357872510414887,-2.098019218719522,0.012790467793391958,1.8931135715202823,0.118037284219573,0.9279807912258029,792]
["P25786-1","Proteasome subunit alpha type-1 [OS=Homo sapiens]",64,17,151,17,263,29.5,6.61,439.06,"protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","PSMA1","ENSCANG00000029071; ENSCATG00000014932; ENSCJAG00000009850; ENSCPOG00000015226; ENSG00000129084; ENSGGOG00000001416; ENSHGLG00000008245; ENSMFAG00000036829; ENSMLEG00000030594; ENSMMUG00000016446; ENSMNEG00000005235; ENSOCUG00000000439; ENSPANG00000016448; ENSPPYG00000003466; ENSPTRG00000003385; ENSRBIG00000037598; ENSRROG00000037748; ENSSSCG00000013391; ENSSTOG00000006270; ENSTSYG00000003869","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration","ER-Phagosome pathway; MAPK6/MAPK4 signaling; Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Downstream TCR signaling; UCH proteinases; Regulation of expression of SLITs and ROBOs; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease",15852.2,15451.4,15571.9,16137.9,16086.5,14506.1,1.0031028985352177,0.004469605543446419,0.9340262605097257,0.029640913240849647,0.9580126211150134,0.018628769371873438,7126]
["P26006","Integrin alpha-3 [OS=Homo sapiens]",1,1,1,1,1051,116.5,6.77,1.82,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","ITGA3","ENSG00000005884","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Hematopoietic cell lineage; Regulation of actin cytoskeleton; Human papillomavirus infection; Pathways in cancer; Small cell lung cancer; Hypertrophic cardiomyopathy; Arrhythmogenic right ventricular cardiomyopathy; Dilated cardiomyopathy","Integrin cell surface interactions; Laminin interactions; MET activates PTK2 signaling; Basigin interactions","Integrin-mediated cell adhesion; Arrhythmogenic right ventricular cardiomyopathy; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ebola virus pathway in host; Small cell lung cancer; Nephrotic syndrome; Genes controlling nephrogenesis; Malignant pleural mesothelioma",64.1,71,64.1,65.1,65.7,93.6,0.8877005347593582,-0.1718550285407121,0.43443027939714673,0.36207991243208265,0.6046945176373539,0.21846396883516667,5251]
["P26358-1","DNA (cytosine-5)-methyltransferase 1 [OS=Homo sapiens]",36,45,110,1,1616,183.1,7.75,300.92,"cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DNMT1","ENSG00000130816","Cysteine and methionine metabolism; Metabolic pathways; MicroRNAs in cancer","NoRC negatively regulates rRNA expression; PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; SUMOylation of DNA methylation proteins","Trans-sulfuration pathway; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration and one-carbon metabolism; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; MTHFR deficiency",403,403.7,369.7,622.5,699,270,0.7391768771599121,-0.43600846763621914,0.3555828370078772,0.4490592093797089,0.5571178897514629,0.2540528955782546,4665]
["P26373-1","60S ribosomal protein L13 [OS=Homo sapiens]",39,10,37,10,211,24.2,11.65,99.04,"protein metabolism;other metabolic processes;developmental processes","cytosol;ER/Golgi;translational apparatus;nucleus","other molecular function","RPL13","ENSG00000167526","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",6482.2,7534.6,5078.9,5994.4,6414.3,5247.7,1.0815171835708297,0.11305658758882174,0.5759221103448222,0.23963624806078124,0.7037978104849199,0.1525520885889153,5981]
["P26885","Peptidyl-prolyl cis-trans isomerase FKBP2 [OS=Homo sapiens]",44,4,14,4,142,15.6,9.13,41.59,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","FKBP2","ENSG00000173486","","","Complement system",1591.6,1621.4,1474.9,1422,1491.2,2248,0.9082965201891033,-0.13876474189604643,0.5881196353526661,0.23053432071195878,0.7106243039829123,0.14835994333533656,6049]
["P27540","Aryl hydrocarbon receptor nuclear translocator [OS=Homo sapiens]",4,3,4,3,789,86.6,6.54,8.99,"stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","ARNT","ENSG00000143437","HIF-1 signaling pathway; Cushing syndrome; Pathways in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Renal cell carcinoma","PPARA activates gene expression; Endogenous sterols; Xenobiotics; Aryl hydrocarbon receptor signalling; Regulation of gene expression by Hypoxia-inducible Factor","Angiogenesis; Aryl hydrocarbon receptor Netpath; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; Type 2 papillary renal cell carcinoma",343.8,320.5,323.5,386.6,382.1,407.9,0.8395376508584056,-0.2523330675348609,4.3356156231910865E-3,2.3629492274213826,0.07268122612363223,1.1385777548059957,436]
["P27695","DNA-(apurinic or apyrimidinic site) lyase [OS=Homo sapiens]",61,17,74,17,318,35.5,8.12,255.72,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytoskeleton;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component","nucleic acid binding activity;other molecular function","APEX1","ENSG00000100823","Base excision repair","Displacement of DNA glycosylase by APEX1; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Abasic sugar-phosphate removal via the single-nucleotide replacement pathway","Thyroid stimulating hormone (TSH) signaling pathway; Spinal cord injury; Base excision repair; DNA repair pathways, full network",9244.8,9409.2,8813.7,8739.9,9806.9,6166.9,1.1114361669843043,0.15242509256671827,0.44894225087174927,0.34780952033462864,0.6141341777319138,0.21173673263356166,5343]
["P27986","Phosphatidylinositol 3-kinase regulatory subunit alpha [OS=Homo sapiens]",16,10,16,9,724,83.5,6.16,43.18,"cell adhesion;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","PIK3R1","ENSG00000145675","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; Platinum drug resistance; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Phosphatidylinositol signaling system; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Osteoclast differentiation; Focal adhesion; Signaling pathways regulating pluripotency of stem cells; Platelet activation; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; TNF signaling pathway; Leukocyte transendothelial migration; Neurotrophin signaling pathway; Cholinergic synapse; Inflammatory mediator regulation of TRP channels; Regulation of actin cytoskeleton; Insulin signaling pathway; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Prolactin signaling pathway; Thyroid hormone signaling pathway; Regulation of lipolysis in adipocytes; Relaxin signaling pathway; GnRH secretion; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Aldosterone-regulated sodium reabsorption; Carbohydrate digestion and absorption; Alzheimer disease; Spinocerebellar ataxia; Prion disease; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection; Chagas disease; Amoebiasis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Signaling by FGFR1 in disease; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; G alpha (q) signalling events; RAC1 GTPase cycle; VEGFA-VEGFR2 Pathway; RHOC GTPase cycle; CDC42 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; RAF/MAP kinase cascade; PI3K Cascade; PI-3K cascade:FGFR4; Signaling by FGFR4 in disease; Downstream TCR signaling; RND2 GTPase cycle; RHOF GTPase cycle; Extra-nuclear estrogen signaling; RHOV GTPase cycle; Signaling by ALK fusions and activated point mutants; RHOU GTPase cycle; Synthesis of PIPs at the plasma membrane; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Regulation of signaling by CBL; Nephrin family interactions; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; Costimulation by the CD28 family; CD28 dependent PI3K/Akt signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; RND3 GTPase cycle; RND1 GTPase cycle; Interleukin-4 and Interleukin-13 signaling; PI3K events in ERBB4 signaling; PI3K events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; GAB1 signalosome; Signaling by cytosolic FGFR1 fusion mutants; PI-3K cascade:FGFR1; PI-3K cascade:FGFR2; Signaling by FGFR2 in disease; PI-3K cascade:FGFR3; Signaling by FGFR3 point mutants in cancer; FLT3 Signaling; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FGFR3 fusions in cancer; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants; GP1b-IX-V activation signalling; MET activates PI3K/AKT signaling; Activated NTRK3 signals through PI3K; Activated NTRK2 signals through PI3K","IL-5 signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase (AMPK) signaling; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Apoptosis; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; IL-6 signaling pathway; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Ebola virus pathway in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Overview of interferons-mediated signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; IL-18 signaling pathway; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; Modulators of TCR signaling and T cell activation; Orexin receptor pathway; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; Interferon type I signaling pathways; Notch signaling pathway (Netpath); ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway",1669.9,1680.9,1679.7,1477,1613.2,1440.8,1.1102405649966895,0.1508723111020765,0.034006866249213924,1.4684333866906008,0.19252996546514684,0.7155016670730481,1291]
["P28072","Proteasome subunit beta type-6 [OS=Homo sapiens]",31,7,35,7,239,25.3,4.92,93.1,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","PSMB6","ENSG00000142507","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease",3519.5,3831,3582.4,3397.3,3005.1,2059.3,1.292045333679993,0.36965669040948024,0.11385291372972164,0.9436558504195242,0.3444333387626389,0.4628948184846454,2416]
["P28288","ATP-binding cassette sub-family D member 3 [OS=Homo sapiens]",22,11,28,11,659,75.4,9.36,86.64,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ABCD3","ENSG00000117528","ABC transporters; Peroxisome","RHOA GTPase cycle; RHOC GTPase cycle; Class I peroxisomal membrane protein import; ABC transporters in lipid homeostasis","Nuclear receptors in lipid metabolism and toxicity; Fragile X syndrome",1891.3,1908.7,1980,1780.8,1746.5,2376,0.9791133772635645,-0.030452167290022605,0.8516986836445815,0.06971402398418129,0.901530148987436,0.045019745014858434,6905]
["P28347","Transcriptional enhancer factor TEF-1 [OS=Homo sapiens]",10,2,2,2,426,47.9,8.15,5.03,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TEAD1","ENSG00000187079","Hippo signaling pathway; Hippo signaling pathway","YAP1- and WWTR1 (TAZ)-stimulated gene expression; EGR2 and SOX10-mediated initiation of Schwann cell myelination; RUNX3 regulates YAP1-mediated transcription","Mesodermal commitment pathway; Mesodermal commitment pathway; miR-509-3p alteration of YAP1/ECM axis; Transcription co-factors SKI and SKIL protein partners; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Overview of leukocyte-intrinsic Hippo pathway functions; Malignant pleural mesothelioma",92.6,78.8,79.2,75.2,89.3,51.8,1.1585760517799348,0.21235274935988133,0.3888536165459275,0.4102138575198741,0.5716273297132309,0.24288701560550824,4972]
["P28702","Retinoic acid receptor RXR-beta [OS=Homo sapiens]",12,4,6,4,533,56.9,8.18,23.05,"signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RXRB","ENSG00000204231; ENSG00000206289; ENSG00000227322; ENSG00000228333; ENSG00000231321; ENSG00000235712","PPAR signaling pathway; Th17 cell differentiation; Thyroid hormone signaling pathway; Adipocytokine signaling pathway; Parathyroid hormone synthesis, secretion and action; Pathways in cancer; Transcriptional misregulation in cancer; Chemical carcinogenesis; Thyroid cancer; Small cell lung cancer; Non-small cell lung cancer; Gastric cancer; Lipid and atherosclerosis","NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; PPARA activates gene expression; Nuclear Receptor transcription pathway; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis; Signaling by Retinoic Acid; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose; NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake ; NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis","Vitamin D metabolism; Nuclear receptors; PPAR signaling pathway; Non-small cell lung cancer; Non-genomic actions of 1,25 dihydroxyvitamin D3; Small cell lung cancer; IL-18 signaling pathway; Vitamin A and carotenoid metabolism",510.9,485.2,552.5,627.3,661.4,618.3,0.8120608285264813,-0.30034029638499266,0.007165277462184352,2.144766987686386,0.08952309909590672,1.0480648918845936,585]
["P29218-1","Inositol monophosphatase 1 [OS=Homo sapiens]",35,8,29,8,277,30.2,5.26,96.42,"other metabolic processes;signal transduction","cytosol;other cell component","other molecular function","IMPA1","ENSG00000133731","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of IP2, IP, and Ins in the cytosol","Integrated breast cancer pathway",2173.8,2119.4,2275.2,2174.2,2075.2,1677.9,1.1081605452735648,0.14816690764281115,0.248543236236247,0.6045980510936564,0.4912391870337288,0.3087069960328377,3698]
["P29466-1","caspase-1 [OS=Homo sapiens]",45,15,58,15,404,45.1,5.91,200.9,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;other cell component","enzyme regulator activity;other molecular function","CASP1","ENSG00000137752","Necroptosis; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; Amyotrophic lateral sclerosis; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Legionellosis; Yersinia infection; Influenza A; Coronavirus disease; Lipid and atherosclerosis","The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; NOD1/2 Signaling Pathway; TP53 Regulates Transcription of Caspase Activators and Caspases; The AIM2 inflammasome; Pyroptosis; Interleukin-37 signaling; Interleukin-1 processing; The IPAF inflammasome","Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis modulation and signaling; Parkin-ubiquitin proteasomal system pathway; Amyotrophic lateral sclerosis (ALS); Apoptosis; Cytosolic DNA-sensing pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Malignant pleural mesothelioma; Prostaglandin signaling",5337.8,5264.1,5484.8,5615.7,5708.6,4189.2,1.0369484642408224,0.05234419479554599,0.7196729109353728,0.14286484419690296,0.8038033780603056,0.09485017297619659,6544]
["P29597","Non-receptor tyrosine-protein kinase TYK2 [OS=Homo sapiens]",4,6,7,5,1187,133.6,7.15,21.06,"protein metabolism;other metabolic processes;stress response;signal transduction","other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","TYK2","ENSG00000105397","Necroptosis; Osteoclast differentiation; NOD-like receptor signaling pathway; JAK-STAT signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease","Potential therapeutics for SARS; Interleukin-4 and Interleukin-13 signaling; Interleukin-10 signaling; Interleukin-6 signaling; Regulation of IFNA signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; IL-6-type cytokine receptor ligand interactions; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-12 signaling; Interleukin-23 signaling; Interleukin-27 signaling; Other interleukin signaling","Type III interferon signaling; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; IL-6 signaling pathway; IL-4 signaling pathway; Immune response to tuberculosis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Overview of interferons-mediated signaling pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Interferon type I signaling pathways",688.1,681.7,743.5,705.7,732.4,1347.3,0.7587061104329721,-0.3983869380061678,0.34712735997970373,0.45951115463764225,0.5532389607700947,0.25708724314758935,4586]
["P30041","Peroxiredoxin-6 [OS=Homo sapiens]",73,18,185,18,224,25,6.38,666,"other metabolic processes;stress response;other biological processes","non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PRDX6","ENSG00000117592","Glutathione metabolism; Metabolic pathways","Neutrophil degranulation; Detoxification of Reactive Oxygen Species","Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling pathway",24032.5,25125.6,23727,23336.3,23487.2,18963.7,1.1078918087409102,0.14781700177153098,0.19993724040286945,0.6991063064564041,0.44525938150657307,0.35138692128950566,3282]
["P30085-1","UMP-CMP kinase [OS=Homo sapiens]",47,10,43,10,196,22.2,5.57,139.27,"other metabolic processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","CMPK1","ENSG00000162368","Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors","Interconversion of nucleotide di- and triphosphates","Pyrimidine metabolism",6575.9,7765.6,6070.1,6616.8,6732.5,5424.5,1.087238598472339,0.12066857979424406,0.45061412388541383,0.3461952000303693,0.6157297871524564,0.21060983604141345,5349]
["P30154","Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [OS=Homo sapiens]",26,13,56,6,601,66.2,4.94,165.5,"protein metabolism;other metabolic processes;other biological processes","other membranes;other cell component","enzyme regulator activity","PPP2R1B","ENSG00000137713","mRNA surveillance pathway; Sphingolipid signaling pathway; Oocyte meiosis; PI3K-Akt signaling pathway; AMPK signaling pathway; Adrenergic signaling in cardiomyocytes; TGF-beta signaling pathway; Hippo signaling pathway; Tight junction; Dopaminergic synapse; Long-term depression; Chagas disease; Hepatitis C; Human papillomavirus infection","Regulation of TP53 Degradation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; DARPP-32 events; Cyclin A/B1/B2 associated events during G2/M transition; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Cyclin D associated events in G1; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; S33 mutants of beta-catenin aren't phosphorylated; S37 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; T41 mutants of beta-catenin aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; MASTL Facilitates Mitotic Progression; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Netrin-UNC5B signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome",1137.1,1143.9,1229,1388.8,1393.9,1137.8,0.8952939676061727,-0.15956662930045606,0.20123382013455826,{"$f":"-LOG10(AA1603)","v":0.6962990282707113},0.4469212978922778,{"$f":"-LOG10(AC1603)","v":0.34976894868111197},3291]
["P30414","NK-tumor recognition protein [OS=Homo sapiens]",8,12,20,12,1462,165.6,9.99,53.52,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","NKTR","ENSG00000114857","","","",2103.6,2081.8,2151.6,2093.4,2149.7,2438.8,0.9483829449707418,-0.0764583762127101,0.3508806216307908,0.4548406162565458,0.5553457045256497,0.25543658295373034,4618]
["P30479","HLA class I histocompatibility antigen, B-41 alpha chain [OS=Homo sapiens]",40,12,106,2,362,40.5,6.54,299.71,"other biological processes","plasma membrane;other membranes","","HLA-B","","","","",3292.2,3375.9,3621.7,2762.2,2901.7,4118.5,1.0518686620870135,0.07295457878927564,0.7214046428149088,0.14182106697689195,0.8049994708907127,0.09420440508470208,6550]
["P30622-2","Isoform 3 of CAP-Gly domain-containing linker protein 1 [OS=Homo sapiens]",28,35,54,1,1392,156.7,5.36,147.85,"","","","CLIP1","","","","",338.7,299.5,303.6,371.3,389,479.7,0.7595161290322581,-0.39684749286207216,0.05001466697654391,1.3009026186058468,0.22947721339080943,0.6392604325230052,1593]
["P31146","Coronin-1A [OS=Homo sapiens]",62,30,362,27,461,51,6.68,1038.25,"cell adhesion;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","CORO1A","ENSG00000102879","Phagosome; Tuberculosis","Prevention of phagosomal-lysosomal fusion","16p11.2 proximal deletion syndrome",43477,41658.5,41672.8,40321.8,39726.6,42214.9,1.037173869836656,0.052657765052454154,0.1907724033388624,0.7194844490474109,0.43614497841843763,0.360369123435126,3197]
["P31153","S-adenosylmethionine synthase isoform type-2 [OS=Homo sapiens]",59,18,128,14,395,43.6,6.48,410.75,"cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;other cell component","other molecular function","MAT2A","ENSG00000168906","Cysteine and methionine metabolism; Metabolic pathways; Biosynthesis of amino acids; Biosynthesis of cofactors","Methylation","Trans-sulfuration and one-carbon metabolism; Methionine de novo and salvage pathway; One-carbon metabolism and related pathways; Methylation pathways",14020.4,13884.7,14291,14292,13405.7,13677.3,1.019845317220544,0.0283503512147788,0.3958764749793735,0.40244030549762055,0.5770764171568091,0.2387666732358453,5014]
["P31641","Sodium- and chloride-dependent taurine transporter [OS=Homo sapiens]",1,1,1,1,620,69.8,7.39,0,"transport;other biological processes","plasma membrane;other membranes;other cell component","transporter activity","SLC6A6","ENSG00000131389","","Na+/Cl- dependent neurotransmitter transporters; Amino acid transport across the plasma membrane","Nuclear receptors meta-pathway; NRF2 pathway",63.4,61.8,70.8,74.7,69.1,114.8,0.7579273008507347,-0.3998686208076838,0.22760584820716792,0.6428165831755964,0.4735471518776516,0.324636771083649,3513]
["P31943","Heterogeneous nuclear ribonucleoprotein H [OS=Homo sapiens]",56,20,433,8,449,49.2,6.3,1435.7,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","HNRNPH1","ENSG00000169045; ENSG00000284254","","mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA","MECP2 and associated Rett syndrome; mRNA processing; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells",30530.5,30171.6,31683.2,32126.9,33206.3,36018.8,0.9115291262135923,-0.13363933925645466,0.07452045430403798,1.1277245061491794,0.27903176255543727,0.5543463575958796,1952]
["P31947-1","14-3-3 protein sigma [OS=Homo sapiens]",62,15,140,11,248,27.8,4.74,392.51,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;nucleus","enzyme regulator activity;other molecular function","SFN","ENSG00000175793; ENSGGOG00000011493; ENSNLEG00000018582; ENSPPAG00000013397; ENSPTRG00000030723","Cell cycle; p53 signaling pathway; Aldosterone-regulated sodium reabsorption","TP53 Regulates Metabolic Genes; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; Activation of BAD and translocation to mitochondria ; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest","miRNA regulation of DNA damage response; Cell cycle; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells; DNA damage response; Calcium regulation in cardiac cells",2078.2,2166.1,2212.5,2237,2133,2660.6,0.9183853440673626,-0.1228284757505548,0.31363383745254797,0.5035770881235617,0.5357208969246724,0.2710614127235216,4279]
["P32246","C-C chemokine receptor type 1 [OS=Homo sapiens]",3,1,1,1,355,41.1,8.16,1.86,"cell adhesion;cell-cell signaling;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","CCR1","ENSG00000163823","Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor; Chemokine signaling pathway; Human cytomegalovirus infection; Kaposi sarcoma-associated herpesvirus infection","G alpha (i) signalling events; Chemokine receptors bind chemokines; Interleukin-10 signaling","Peptide GPCRs; Chemokine signaling pathway; Selective expression of chemokine receptors during T-cell polarization; GPCRs, class A rhodopsin-like; CCL18 signaling pathway",114.2,115.9,117.9,258.2,272.4,240.4,0.4513618677042803,-1.1476435540663057,1.1120892003290631E-4,3.9538603767314573,0.015631269163856005,1.8060057584822835,52]
["P32455","Guanylate-binding protein 1 [OS=Homo sapiens]",35,18,53,16,592,67.9,6.32,161.45,"stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","GBP1","ENSG00000117228","NOD-like receptor signaling pathway","Interferon gamma signaling","Type II interferon signaling (IFNG)",5835.9,5647.1,5821.7,5838.2,5614.4,7399.3,0.9179286968422282,-0.12354600302098925,0.412736436768477,0.3843271894967644,0.5886225592860095,0.23016309734058335,5125]
["P33121","Long-chain-fatty-acid--CoA ligase 1 [OS=Homo sapiens]",8,7,12,6,698,77.9,7.15,31.55,"other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle","other molecular function","ACSL1","ENSG00000151726","Fatty acid biosynthesis; Fatty acid degradation; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; Peroxisome; Ferroptosis; Thermogenesis; Adipocytokine signaling pathway","PPARA activates gene expression; Synthesis of very long-chain fatty acyl-CoAs; alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism","Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters",907.3,927,973.8,954.5,881.7,1926.4,0.7463190347100409,-0.42213561266087,0.3989923692776811,0.3990354101084541,0.5796531955974104,0.2368317655502293,5031]
["P33981","Dual specificity protein kinase TTK [OS=Homo sapiens]",6,5,6,5,857,97,8.16,15.62,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","TTK","ENSG00000112742","Cell cycle","","Cell cycle; Retinoblastoma gene in cancer",568.4,590.9,570.8,596.3,551.9,437.3,1.0912015137180702,0.125917550787075,0.37123172253948244,0.43035491948119625,0.5626986022482533,0.24972416363865813,4822]
["P33993-1","DNA replication licensing factor MCM7 [OS=Homo sapiens]",68,42,230,42,719,81.3,6.46,689.22,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","MCM7","ENSG00000166508","DNA replication; Cell cycle","Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Assembly of the pre-replicative complex; Unwinding of DNA","miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication",25835.4,25926.3,26541.4,24061.8,23234.6,20324.3,1.1579752945473798,0.21160447369485957,0.036815909600248026,1.4339644650640033,0.19976799054804217,0.699474098903016,1347]
["P34932","Heat shock 70 kDa protein 4 [OS=Homo sapiens]",77,56,447,51,840,94.3,5.19,1386.98,"cell organization and biogenesis;stress response;transport","non-structural extracellular;cytosol;mitochondrion;nucleus","other molecular function","HSPA4","ENSG00000170606","Tight junction; Antigen processing and presentation; Lipid and atherosclerosis","Regulation of HSF1-mediated heat shock response","Parkin-ubiquitin proteasomal system pathway",52469.4,51830.4,52244.1,50395.3,50025.7,42113.3,1.0982893240434057,0.1352581557810018,0.15967039571199398,0.7967755983934282,0.39966812406128904,0.39830048795787354,2920]
["P35236","Tyrosine-protein phosphatase non-receptor type 7 [OS=Homo sapiens]",31,8,27,8,360,40.5,6.79,80.38,"protein metabolism;other metabolic processes;signal transduction","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","PTPN7","ENSG00000143851","MAPK signaling pathway","Interleukin-37 signaling; Negative regulation of MAPK pathway","MAPK signaling pathway; IL-18 signaling pathway",3001.5,2949.8,2980.5,3030.4,2828.2,2957.7,1.0131007338679492,0.01877763023620396,0.562263693198511,0.25005995908817175,0.6936009001836146,0.1588903518863403,5925]
["P35241-1","radixin [OS=Homo sapiens]",55,38,230,19,583,68.5,6.37,622.21,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","RDX","ENSG00000137710; ENSPPAG00000040677; ENSRBIG00000033138; ENSRROG00000036137","Tight junction; Regulation of actin cytoskeleton; Proteoglycans in cancer; MicroRNAs in cancer","Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea","Regulation of actin cytoskeleton",8895,9071.6,8797.3,9634.7,9424,10184.9,0.9152053782708011,-0.1278325646440774,0.02640638039587787,1.5782911247995002,0.16870999502925815,0.7728591873725328,1144]
["P35556","Fibrillin-2 [OS=Homo sapiens]",0,1,1,1,2912,314.6,4.86,0,"developmental processes;other biological processes","non-structural extracellular;extracellular matrix","extracellular structural activity;other molecular function","FBN2","ENSG00000138829","","Degradation of the extracellular matrix; Molecules associated with elastic fibres","Hypothesized pathways in pathogenesis of cardiovascular disease",19.1,20.6,67,142.3,61.3,142.3,0.3084706562590344,-1.696794837548503,0.06317539369177977,1.1994520429951505,0.25384769240968574,0.595426780174661,1819]
["P35568","Insulin receptor substrate 1 [OS=Homo sapiens]",3,3,5,3,1242,131.5,8.54,11.72,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","IRS1","ENSG00000169047","cGMP-PKG signaling pathway; FoxO signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Neurotrophin signaling pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Regulation of lipolysis in adipocytes; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; Growth hormone synthesis, secretion and action; Aldosterone-regulated sodium reabsorption; Alzheimer disease; MicroRNAs in cancer; Diabetic cardiomyopathy","RAF/MAP kinase cascade; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by ALK fusions and activated point mutants; PI3K Cascade; Interleukin-7 signaling; PI3K/AKT activation; Signaling by ALK; Growth hormone receptor signaling; Signaling by Leptin; SOS-mediated signalling; IRS activation; Signal attenuation; Activated NTRK3 signals through PI3K","Type II diabetes mellitus; Integrated breast cancer pathway; Leptin signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; AGE/RAGE pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Transcription factor regulation in adipogenesis; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; PI3K-Akt signaling pathway; Nonalcoholic fatty liver disease; Gastrin signaling pathway; Insulin signaling; FOXA2 pathway; Neuroinflammation and glutamatergic signaling; Congenital generalized lipodystrophy (CGL); Alzheimer's disease; EPO receptor signaling; Interferon type I signaling pathways; DNA damage response (only ATM dependent)",332.9,320,354.5,538.4,529.7,623.2,0.5956364926387986,-0.7474959492007013,1.9286758158221422E-3,2.714740765218459,0.050525776121304794,1.2964870066080838,279]
["P35612-1","Beta-adducin [OS=Homo sapiens]",17,9,14,9,726,80.8,5.92,31.34,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ADD2","ENSG00000075340","","Miscellaneous transport and binding events","",849.4,926.4,870.1,951.9,917.1,1201.3,0.8617724652314106,-0.21462109171489727,0.2005495128222468,0.6977783886754378,0.44594353185816915,0.35072013087308923,3287]
["P35813","Protein phosphatase 1A [OS=Homo sapiens]",39,13,32,12,382,42.4,5.36,89.7,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus","other molecular function","PPM1A","ENSG00000100614","MAPK signaling pathway","Energy dependent regulation of mTOR by LKB1-AMPK; Downregulation of SMAD2/3:SMAD4 transcriptional activity","TGF-beta signaling pathway; MAPK signaling pathway",3236.6,3194.1,3271.8,3348.5,3301.5,4933.9,0.8375849239030033,-0.25569262015221095,0.3076856119417064,0.5118928118462054,0.5311464661506689,0.27478570364562566,4234]
["P35998","26S proteasome regulatory subunit 7 [OS=Homo sapiens]",67,25,125,25,433,48.6,5.95,394.41,"protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","PSMC2","ENSG00000161057","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection","Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of expression of SLITs and ROBOs; Downstream TCR signaling; Interleukin-1 signaling; Neutrophil degranulation; AUF1 (hnRNP D0) binds and destabilizes mRNA; MAPK6/MAPK4 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Orc1 removal from chromatin; SCF(Skp2)-mediated degradation of p27/p21; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease",12046.1,11907.2,12114.4,12173,11663.1,9645.7,1.0772330041992964,0.10733033683231274,0.3278465523356664,0.4843293790539502,0.5439796710604735,0.26441732991804395,4405]
["P36551","Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial [OS=Homo sapiens]",43,18,69,18,454,50.1,8.25,212.4,"other metabolic processes","cytosol;mitochondrion;other cell component","other molecular function","CPOX","ENSG00000080819","Porphyrin and chlorophyll metabolism; Metabolic pathways; Biosynthesis of cofactors","Heme biosynthesis","Heme biosynthesis",6964.6,6910.1,7307.3,7153.6,6752.8,8091.3,0.962918850607109,-0.05451387393152358,0.5487085492106687,0.2606582731808234,0.6836874848586392,0.16514236994138382,5866]
["P36969","Phospholipid hydroperoxide glutathione peroxidase, mitochondrial [OS=Homo sapiens]",38,8,39,8,197,22.2,8.37,102.9,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","GPX4","ENSG00000167468","Glutathione metabolism; Metabolic pathways; Ferroptosis","Synthesis of 15-eicosatetraenoic acid derivatives; Synthesis of 12-eicosatetraenoic acid derivatives; Synthesis of 5-eicosatetraenoic acids","Glutathione metabolism; Selenium micronutrient network; Folate metabolism; One-carbon metabolism and related pathways; Ferroptosis; Metapathway biotransformation Phase I and II",3709.2,3943.1,3777.1,3059.1,2700.2,3102.3,1.289767084950799,0.3671105573341905,0.004136880104256577,2.383327065716602,0.07165037128438702,1.144781554794303,422]
["P37235","Hippocalcin-like protein 1 [OS=Homo sapiens]",52,10,18,10,193,22.3,5.35,42.62,"","other membranes","other molecular function","HPCAL1","ENSG00000115756","","","",2145.3,2672.2,2229.8,2692.4,2662.7,3285.2,0.8156314016874414,-0.2940107749194939,0.11102032957510964,0.9545974877550225,0.34065809776006567,0.46768128301780826,2382]
["P38432","coilin [OS=Homo sapiens]",16,10,16,10,576,62.6,9.07,42.12,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","COIL","ENSG00000121058","","","Genotoxicity pathway",1432.3,1408.8,1440.2,1873.8,2051.8,2588.2,0.6572661119469434,-0.6054504919869131,0.025755678893687593,1.5891269980685334,0.1662970468497903,0.7791154630368131,1132]
["P38606","V-type proton ATPase catalytic subunit A [OS=Homo sapiens]",66,30,212,30,617,68.3,5.52,604.83,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ATP6V1A","ENSG00000114573","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis","Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Proximal tubule transport",19821.3,19923.5,20327.2,19573.5,18777,16701.5,1.0911865145680446,0.1258977200337174,0.12673371792009128,0.8971078242760875,0.3608479720599716,0.44267573106355784,2567]
["P39210","Protein Mpv17 [OS=Homo sapiens]",16,2,3,2,176,19.7,9.47,5.65,"cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","transporter activity","MPV17","ENSG00000115204","Peroxisome","Peroxisomal protein import","",322.4,277,362,280,369.3,340.7,0.971111111111111,-0.04229172171643881,0.8042514074779705,0.09460817038946025,0.8680262163698297,0.06146715794238491,6772]
["P40306","Proteasome subunit beta type-10 [OS=Homo sapiens]",27,6,23,6,273,28.9,7.81,77.74,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PSMB10","ENSG00000205220","Proteasome","Regulation of PTEN stability and activity; FCERI mediated NF-kB activation; Downstream TCR signaling; Regulation of expression of SLITs and ROBOs; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; MAPK6/MAPK4 signaling; Degradation of beta-catenin by the destruction complex; ER-Phagosome pathway; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; CDT1 association with the CDC6:ORC:origin complex; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation",2738.2,2687,2628.8,2768.7,2808.6,3426.3,0.8945310764583057,-0.16079649179016578,0.21527418200473716,0.6670080523187243,0.4611485921080375,0.3361591129302368,3412]
["P40616","ADP-ribosylation factor-like protein 1 [OS=Homo sapiens]",64,9,33,9,181,20.4,5.72,97.08,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","ARL1","ENSG00000120805","","Retrograde transport at the Trans-Golgi-Network","",2325.8,2662.9,2260.8,2187.3,2186.1,1673.5,1.1988787643255225,0.2616857747240542,0.13113776312365424,0.882272228564417,0.3673767384709808,0.43488834578066476,2609]
["P40937-1","Replication factor C subunit 5 [OS=Homo sapiens]",45,13,39,13,340,38.5,7.2,117.6,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RFC5","ENSG00000111445","DNA replication; Nucleotide excision repair; Mismatch repair","Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER","Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair",4586.3,4582.7,4665,4415,3909.8,4728.2,1.0598329885849995,0.08383693882271301,0.33890118727545543,0.4699269096923485,0.5487436370838067,0.2606305025501189,4514]
["P41226","ubiquitin-like modifier-activating enzyme 7 [OS=Homo sapiens]",8,7,9,7,1012,111.6,6.04,25.58,"protein metabolism;other metabolic processes;stress response","cytosol;nucleus;other cell component","other molecular function","UBA7","ENSG00000182179","Ubiquitin mediated proteolysis; Parkinson disease; Pathways of neurodegeneration","Termination of translesion DNA synthesis; Antigen processing: Ubiquitination & Proteasome degradation; ISG15 antiviral mechanism; Negative regulators of DDX58/IFIH1 signaling","Proteasome degradation; Parkinson's disease pathway",1039,1032.5,1037.3,1052.4,967.9,1962.7,0.7805171980918905,-0.357497673666204,0.4119447529607019,0.38516102448422634,0.5880672264433144,0.23057302357608414,5120]
["P41227-1","N-alpha-acetyltransferase 10 [OS=Homo sapiens]",47,12,58,12,235,26.4,5.64,151.74,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","translation activity;other molecular function","NAA10","ENSCATG00000038709; ENSCSAG00000006823; ENSG00000102030; ENSGGOG00000009788; ENSMFAG00000044161; ENSMMUG00000000322; ENSMNEG00000034261; ENSPPYG00000020861; ENSPTRG00000022419; ENSRROG00000041881","","","",4977.3,5226.2,4894,5753.6,5395,7997,{"$f":"AVERAGE(S1794:U1794)/AVERAGE(V1794:X1794)","v":0.7885623850910916},{"$f":"LOG(Y1794,2)","v":-0.3427032002377348},{"$f":"TTEST(V1794:X1794,S1794:U1794,2,2)","v":0.17530824493465952},0.7561976580909046,{"$f":"AA1794*7309/AE1794","v":0.4166920202365615},0.38018481631836704,3075]
["P41567","eukaryotic translation initiation factor 1 [OS=Homo sapiens]",39,4,6,4,113,12.7,7.44,21.11,"protein metabolism;other metabolic processes;other biological processes","translational apparatus;nucleus;other cell component","translation activity;nucleic acid binding activity","EIF1","ENSG00000173812","","","Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell",260.3,269.6,271.3,293.4,302.3,274.4,0.9208136995747614,-0.1190187972973815,0.061482040833008365,1.2112517249750971,0.25345303804199554,0.5961024986920419,1773]
["P42167-2","Isoform Gamma of Lamina-associated polypeptide 2, isoforms beta/gamma [OS=Homo sapiens]",54,18,162,2,345,38.7,9.16,512.19,"","","","TMPO","","","","",501.1,497.1,482.8,585.6,606.7,486.7,0.8820726622989874,-0.18103058964818253,0.15240339649873252,0.8170053540973357,0.39098505616329804,0.40783984145283947,2849]
["P42285","Superkiller viralicidic activity 2-like 2 [OS=Homo sapiens]",29,28,77,28,1042,117.7,6.52,226.12,"RNA metabolism OR transcription;other metabolic processes;stress response","nucleus","other molecular function","MTREX","ENSG00000039123","RNA degradation","Major pathway of rRNA processing in the nucleolus and cytosol; mRNA Splicing - Major Pathway","",7337.2,7689.1,7466.6,9534.3,9726.6,7600.9,0.8373563945826415,-0.2560863033405003,0.1011980715253429,0.9948277635227232,0.3281529302478843,0.48392371334883794,2254]
["P42574","Caspase-3 [OS=Homo sapiens]",50,10,57,9,277,31.6,6.54,162.65,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","CASP3","ENSG00000164305","Platinum drug resistance; MAPK signaling pathway; p53 signaling pathway; Apoptosis; Apoptosis; Natural killer cell mediated cytotoxicity; IL-17 signaling pathway; TNF signaling pathway; Serotonergic synapse; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Alcoholic liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Salmonella infection; Pertussis; Legionellosis; Toxoplasmosis; Amoebiasis; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Colorectal cancer; Small cell lung cancer; Viral myocarditis; Lipid and atherosclerosis","Caspase-mediated cleavage of cytoskeletal proteins; Degradation of the extracellular matrix; Other interleukin signaling; Apoptosis induced DNA fragmentation; Signaling by Hippo; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Caspase activation via Dependence Receptors in the absence of ligand; Pyroptosis; NADE modulates death signalling; Apoptotic cleavage of cell adhesion  proteins; Stimulation of the cell death response by PAK-2p34","miRNA regulation of DNA damage response; Integrated breast cancer pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; AGE/RAGE pathway; Allograft Rejection; Corticotropin-releasing hormone signaling pathway; Parkinson's disease pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Copper homeostasis; Hepatitis C and hepatocellular carcinoma; MAPK signaling pathway; Apoptosis modulation by HSP70; ERK pathway in Huntington's disease; Oxidative damage response; miRNA regulation of p53 pathway in prostate cancer; Prion disease pathway; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; MTHFR deficiency; Acute viral myocarditis; Nonalcoholic fatty liver disease; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; Peroxiredoxin 2 induced ovarian failure; Complement system in neuronal development and plasticity; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; Sudden infant death syndrome (SIDS) susceptibility pathways; DNA damage response",6356.5,6312.6,6446.6,7027.1,6930.9,6633.7,0.9283206340418713,-0.1073049088795083,0.016926578220039654,1.7714308274995494,0.13476727691750526,0.8704155468168188,918]
["P42680","Tyrosine-protein kinase Tec [OS=Homo sapiens]",8,5,9,5,631,73.5,8.44,26.54,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton","kinase activity;other molecular function","TEC","ENSG00000135605","Osteoclast differentiation; T cell receptor signaling pathway","FCERI mediated Ca+2 mobilization; Interleukin-3, Interleukin-5 and GM-CSF signaling; Signaling by SCF-KIT","Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; Kit receptor signaling pathway",926.9,969.2,1006.7,893.9,946.5,1255.9,0.9375060556147659,-0.09310008558915964,0.6055838148906004,0.21782574050539436,0.7221752493123509,0.14135739997353142,6129]
["P42766","60S ribosomal protein L35 [OS=Homo sapiens]",28,4,12,4,123,14.5,11.05,22.64,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;translational apparatus;nucleus","nucleic acid binding activity;other molecular function","RPL35","ENSG00000136942","Ribosome; Coronavirus disease","Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",2806.5,2836.9,2376.4,2417.4,2643.8,2010.2,1.1341177136069234,0.18157038985979293,0.2541917221820203,0.5948385964618154,0.49517252063656353,0.30524346428486926,3752]
["P43243","Matrin-3 [OS=Homo sapiens]",46,44,247,44,847,94.6,6.25,724.57,"stress response;developmental processes;other biological processes","other membranes;nucleus","nucleic acid binding activity;other molecular function","MATR3","ENSG00000015479","Amyotrophic lateral sclerosis","","",31654.7,30933.4,31553.3,34868.3,35524.9,29746.6,0.9400997405626933,-0.08911426620180052,0.3383749692486698,0.4706017706898779,0.5487425449830325,0.26063136687688243,4507]
["P43246-1","DNA mismatch repair protein MSH2 [OS=Homo sapiens]",46,34,131,34,934,104.7,5.77,390.5,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MSH2","ENSG00000095002","Platinum drug resistance; Mismatch repair; Pathways in cancer; Colorectal cancer","TP53 Regulates Transcription of DNA Repair Genes; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MSH3; Defective Mismatch Repair Associated With MSH2; Defective Mismatch Repair Associated With MSH6","RAC1/PAK1/p38/MMP2 pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ciliary landscape; DNA repair pathways, full network; p53 transcriptional gene network; DNA mismatch repair",15968.3,15909.9,16119.2,15945.3,15454.3,16052.4,1.0114937199696534,0.01648736270710703,0.4026424055675206,0.39508048793185074,0.5822938943990914,0.2348577636317738,5054]
["P43490","nicotinamide phosphoribosyltransferase [OS=Homo sapiens]",64,26,133,26,491,55.5,7.15,417.93,"cell-cell signaling;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","NAMPT","ENSG00000105835","Nicotinate and nicotinamide metabolism; Metabolic pathways; NOD-like receptor signaling pathway","BMAL1:CLOCK,NPAS2 activates circadian gene expression; Nicotinamide salvaging","Adipogenesis; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; Caloric restriction and aging; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence",15234.8,15127.3,15616.5,15764.1,14495.6,14702.5,1.0226056554172172,0.03224990983865949,0.4651041395206172,0.3324497951628299,0.6238660590486678,0.20490864118296584,5449]
["P45880","Voltage-dependent anion-selective channel protein 2 [OS=Homo sapiens]",65,14,219,13,294,31.5,7.56,684.41,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","transporter activity;other molecular function","VDAC2","ENSG00000165637","Calcium signaling pathway; cGMP-PKG signaling pathway; Ferroptosis; Necroptosis; Cellular senescence; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Cholesterol metabolism; Alzheimer disease; Parkinson disease; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Human T-cell leukemia virus 1 infection; Chemical carcinogenesis; Diabetic cardiomyopathy","Ub-specific processing proteases; Mitochondrial calcium ion transport","Alzheimer's disease and miRNA effects; Ferroptosis; Alzheimer's disease",19829.6,19634.4,20088.9,16009.5,15971.1,11325.8,1.3751524024162711,0.4595915153835327,0.025571830871519326,1.59223817659109,0.1656954892198003,0.7806893143544406,1128]
["P46013","Proliferation marker protein Ki-67 [OS=Homo sapiens]",54,140,476,13,3256,358.5,9.45,1457.52,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MKI67","ENSG00000148773","","","Primary focal segmental glomerulosclerosis (FSGS)",53124.1,52641.5,52009.8,58365.7,60126.3,61058.2,0.8787258382335414,-0.18651497902637657,1.0454225987554756E-3,2.980708116053152,0.03979684257449881,1.4001513828727286,192]
["P46108-1","Adapter molecule crk [OS=Homo sapiens]",21,4,6,4,304,33.8,5.55,20.67,"cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","Crk; CRK","ENSANAG00000030093; ENSBTAG00000005665; ENSCANG00000032179; ENSCATG00000041862; ENSCCAG00000032085; ENSG00000167193; ENSGGOG00000006758; ENSLAFG00000010559; ENSMFAG00000000502; ENSMMUG00000040390; ENSMNEG00000039514; ENSPPAG00000029995; ENSPTRG00000045379; ENSRBIG00000006454; ENSRROG00000035466","MAPK signaling pathway; ErbB signaling pathway; Rap1 signaling pathway; Chemokine signaling pathway; Focal adhesion; Fc gamma R-mediated phagocytosis; Neurotrophin signaling pathway; Regulation of actin cytoskeleton; Insulin signaling pathway; Growth hormone synthesis, secretion and action; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection; Human cytomegalovirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; MicroRNAs in cancer; Renal cell carcinoma; Chronic myeloid leukemia","Regulation of signaling by CBL; ARMS-mediated activation; FCGR3A-mediated phagocytosis; Regulation of signaling by CBL; Regulation of actin dynamics for phagocytic cup formation; Downstream signal transduction; VEGFA-VEGFR2 Pathway; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; ARMS-mediated activation; p130Cas linkage to MAPK signaling for integrins; MET activates RAP1 and RAC1; MET receptor recycling","Kit receptor signaling pathway; TCR signaling pathway; B cell receptor signaling pathway; ErbB signaling pathway; Hepatocyte growth factor receptor signaling; Actin cytoskeleton regulation; Integrin-mediated cell adhesion; Integrin-mediated cell adhesion; B cell receptor signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; Focal adhesion; Interferon type I signaling pathways; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Rett syndrome causing genes; EGF/EGFR signaling pathway; Gastrin signaling pathway; Insulin signaling; Regulation of actin cytoskeleton; Interferon type I signaling pathways; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; EGFR1 signaling pathway; MAPK signaling pathway; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; Integrin-mediated cell adhesion; Insulin signaling; EGF/EGFR signaling pathway; MAPK signaling pathway",473.3,578.2,476.8,492.2,510.6,363.9,1.1182410185117437,0.16123117095095935,0.4022740892941128,0.3954779396857195,0.5822220432971625,0.23491135592040782,5050]
["P46736","Lys-63-specific deubiquitinase BRCC36 [OS=Homo sapiens]",27,8,28,1,316,36,5.92,93.21,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","BRCC3","ENSG00000185515","Homologous recombination; NOD-like receptor signaling pathway","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs","",1966.4,1930.6,2023.9,1942.2,1926.3,1714.7,1.0604850265080956,0.08472425091559645,0.22343041085882567,0.6508577158698098,0.4696729574251242,0.32820444466909526,3477]
["P46777","60S ribosomal protein L5 [OS=Homo sapiens]",64,20,365,20,297,34.3,9.72,1037.11,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;ER/Golgi;translational apparatus;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","RPL5","ENSG00000122406","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; SRP-dependent cotranslational protein targeting to membrane; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","VEGFA-VEGFR2 signaling pathway; Cytoplasmic ribosomal proteins",45290.6,45261.1,45161.3,46480.4,47979.2,46094.6,0.9655563476580564,-0.0505676408747968,0.04876060657477689,1.311930900460548,0.2280174494274116,0.642031916595762,1563]
["P46940","Ras GTPase-activating-like protein IQGAP1 [OS=Homo sapiens]",63,84,618,82,1657,189.1,6.48,2180.23,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","IQGAP1","ENSG00000140575","Adherens junction; Regulation of actin cytoskeleton; Proteoglycans in cancer","Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; RHOV GTPase cycle; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHO GTPases activate IQGAPs; RAC2 GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants","VEGFA-VEGFR2 signaling pathway; Ebola virus pathway in host; Ciliary landscape; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway",62358.9,62045.7,62858.2,56989,56244.8,43318.6,1.1961669064159988,0.25841870914996207,0.08263223654280219,1.0828504923718087,0.2937543856475395,0.5320156408110739,2056]
["P46976-2","Isoform GN-1 of Glycogenin-1 [OS=Homo sapiens]",39,10,56,10,333,37.5,5.4,196.35,"","","","GYG1","","","","",5142.5,5252.2,5209.3,4948.4,5270.3,4639,1.0502298471499627,0.07070510222932337,0.2499714071429587,0.6021096650487833,0.49193349887126686,0.30809360256857193,3714]
["P47985","cytochrome b-c1 complex subunit Rieske, mitochondrial [OS=Homo sapiens]",37,10,82,10,274,29.6,8.32,229.58,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity;other molecular function","UQCRFS1","ENSG00000169021","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly",8161.7,8066,7943.8,7146.1,6960.7,5919.7,1.2069757571218136,0.2713966989335455,0.0233417058603449,1.6318674079880455,0.15767516463332798,0.8022367068746232,1082]
["P48163","NADP-dependent malic enzyme [OS=Homo sapiens]",31,13,54,13,572,64.1,6.13,156.68,"other metabolic processes;other biological processes","cytosol;mitochondrion","other molecular function","ME1","ENSG00000065833","Pyruvate metabolism; Metabolic pathways; Carbon metabolism; PPAR signaling pathway","PPARA activates gene expression; Pyruvate metabolism","Nuclear receptors meta-pathway; NRF2 pathway; PPAR signaling pathway; Clear cell renal cell carcinoma pathways; TCA cycle in senescence",5238.7,5060.5,5231.9,5523.8,5140.7,4519.9,1.0228326440293987,0.03257011049840603,0.7181337583327677,0.1437946572958948,0.8025748684486543,0.0955144437361891,6540]
["P48431","Transcription factor SOX-2 [OS=Homo sapiens]",3,1,1,1,317,34.3,9.74,1.83,"cell organization and biogenesis;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SOX2","ENSG00000181449","Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells","Interleukin-4 and Interleukin-13 signaling; POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation; Transcriptional Regulation by MECP2; Deactivation of the beta-catenin transactivating complex; POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation","Cell differentiation - expanded index; Cardiac progenitor differentiation; Endoderm differentiation; Dopaminergic neurogenesis; Mesodermal commitment pathway; Ectoderm differentiation; let-7 inhibition of ES cell reprogramming; Pre-implantation embryo; Wnt signaling pathway and pluripotency; Sudden infant death syndrome (SIDS) susceptibility pathways",178,165.2,170.4,308.6,311.1,659.5,0.40150093808630394,-1.316524736358029,0.09385289822986095,1.0275523115796488,0.31567916850531696,0.5007540760162003,2173]
["P48553","Trafficking protein particle complex subunit 10 [OS=Homo sapiens]",3,4,7,4,1259,142.1,6.04,17.74,"transport","cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","TRAPPC10","ENSG00000160218","","COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs","",617.6,601,643,785.4,660.6,932,0.7828427249789739,-0.35320559922766964,0.09596172066374124,1.0179019734171249,0.31895598741759196,0.4962692408939423,2199]
["P48723","Heat shock 70 kDa protein 13 [OS=Homo sapiens]",22,9,30,9,471,51.9,5.76,85.01,"stress response;other biological processes","mitochondrion;ER/Golgi;other cell component","other molecular function","HSPA13","ENSG00000155304","","Regulation of HSF1-mediated heat shock response","",2956.1,2905.8,2908.6,3625.2,3624.9,6151.5,0.6544367836676218,-0.6116742553432437,0.1407853279570205,0.851442603143646,0.37928491044521295,0.42103443502126914,2713]
["P48729-3","Isoform 3 of Casein kinase I isoform alpha [OS=Homo sapiens]",24,8,14,1,325,37.5,9.48,22.4,"","","","CSNK1A1","","","","",71.5,49.1,71.3,71.2,71.7,78.4,0.8671486669679168,-0.20564873960563146,0.27668263274737404,0.5580181004857057,0.5111914466002419,0.29141642152687447,3956]
["P49116-1","Nuclear receptor subfamily 2 group C member 2 [OS=Homo sapiens]",8,4,8,4,596,65.4,6.28,19.2,"developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NR2C2","ENSCANG00000032916; ENSG00000177463; ENSMLEG00000044042; ENSMMUG00000005156; ENSPPAG00000023138","","Nuclear Receptor transcription pathway","Androgen receptor signaling pathway; Nuclear receptors; Hypothesized pathways in pathogenesis of cardiovascular disease; Epithelial to mesenchymal transition in colorectal cancer; Androgen receptor signaling pathway; Nuclear receptors",662.3,675,714.7,819.6,786.9,727.9,0.8790267306374229,-0.18602105742347455,0.03901076182021961,1.4088155685016661,0.20527693170913255,0.6876598523553088,1389]
["P49137","MAP kinase-activated protein kinase 2 [OS=Homo sapiens]",17,7,14,5,400,45.5,8.68,31.3,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","MAPKAPK2","ENSG00000162889","MAPK signaling pathway; Cellular senescence; VEGF signaling pathway; C-type lectin receptor signaling pathway; Neurotrophin signaling pathway; Kaposi sarcoma-associated herpesvirus infection; Viral carcinogenesis","VEGFA-VEGFR2 Pathway; Oxidative Stress Induced Senescence; activated TAK1 mediates p38 MAPK activation; Regulation of HSF1-mediated heat shock response; p38MAPK events; CREB phosphorylation; Synthesis of Leukotrienes (LT) and Eoxins (EX); Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA","IL-1 signaling pathway; Microtubule cytoskeleton regulation; Interleukin-1 (IL-1) structural pathway; Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; VEGFA-VEGFR2 signaling pathway; p38 MAPK signaling pathway; Malignant pleural mesothelioma; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling",1329.3,1293.6,1300.3,1280.7,1331.5,1593.3,0.9328736178813459,-0.10024645133018042,0.38899223935635613,0.4100590630401822,0.5717161225529072,0.24281956038843414,4973]
["P49356","protein farnesyltransferase subunit beta [OS=Homo sapiens]",5,2,6,2,437,48.7,5.82,28.73,"protein metabolism;other metabolic processes","cytosol;cytoskeleton;other cell component","other molecular function","FNTB","ENSG00000257365","Terpenoid backbone biosynthesis","RAS processing; Potential therapeutics for SARS; Inactivation, recovery and regulation of the phototransduction cascade","",484.1,486.5,497.4,482.9,463.5,440.3,1.0586283983558087,0.08219626078348449,0.10501374564067663,0.9787538507854545,0.3347341765755366,0.4752999436314204,2293]
["P49406","39S ribosomal protein L19, mitochondrial [OS=Homo sapiens]",34,9,28,9,292,33.5,9.5,78.73,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus","other molecular function","MRPL19","ENSG00000115364","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Cytoplasmic ribosomal proteins",3690,3749.4,3655.5,3326.3,3109,2288.6,1.2717821157968339,0.346851526452009,0.06734703251519603,1.1716815356598995,0.26464487131912245,0.5773365179938429,1860]
["P49454","Centromere protein F [OS=Homo sapiens]",19,55,69,54,3210,367.5,5.07,183.38,"","","","","","","","",4949.9,4866,4845.6,5651.7,5906.9,7448.6,0.7713655877772635,-0.3745133091105824,0.06154643651714153,1.210797087261394,0.25328992370708747,0.5963820868200033,1776]
["P49642","DNA primase small subunit [OS=Homo sapiens]",20,5,8,5,420,49.9,8.21,27.68,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","PRIM1","ENSG00000198056","DNA replication","Activation of the pre-replicative complex; Removal of the Flap Intermediate; Polymerase switching on the C-strand of the telomere; Polymerase switching; Defective pyroptosis; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Telomere C-strand synthesis initiation; DNA replication initiation","Retinoblastoma gene in cancer; Pyrimidine metabolism; G1 to S cell cycle control; DNA replication",447.9,486.3,477,471.3,484.7,421.6,1.024390243902439,0.03476541816067663,0.6434626236082133,0.19147667460596057,0.7486578026030613,0.12571664478447356,6282]
["P49736","DNA replication licensing factor mcm2 [OS=Homo sapiens]",53,38,216,38,904,101.8,5.52,634.35,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MCM2","ENSG00000073111","DNA replication; Cell cycle","Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Assembly of the pre-replicative complex; Unwinding of DNA","Cell cycle; Ciliary landscape; G1 to S cell cycle control; DNA replication",22164,21819.5,22307.4,21544.8,21171.9,19868.8,1.0592054070032195,0.08298239190733454,0.07954890094968131,1.0993658162032702,0.2879756894706393,0.5406441732629366,2019]
["P49750-4","Isoform 4 of YLP motif-containing protein 1 [OS=Homo sapiens]",19,36,59,35,2146,241.5,6.55,155.29,"other biological processes","cytosol;nucleus","","YLPM1","ENSG00000119596","","","",6960.3,6653.4,6705.1,7504.5,7360.1,8231.2,0.8797616882723266,-0.1848153185347519,0.03169084054873071,1.499066241692175,0.18456442515591456,0.733852005625259,1255]
["P49770","Translation initiation factor eIF-2B subunit beta [OS=Homo sapiens]",27,8,18,8,351,39,6.16,55.22,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF2B2","ENSG00000119718","Herpes simplex virus 1 infection","Recycling of eIF2:GDP","Translation factors; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Rett syndrome causing genes",1235.1,1208.8,1267.8,1291.8,1320.8,2237.3,0.7653147487577064,-0.385874892070755,0.2893819200753474,{"$f":"-LOG10(AA1987)","v":0.5385286061015447},0.5190410929645924,{"$f":"-LOG10(AC1987)","v":0.2847982572935672},4075]
["P49773","Histidine triad nucleotide-binding protein 1 [OS=Homo sapiens]",48,4,23,4,126,13.8,6.95,82.96,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","HINT1","ENSG00000169567","","","",3436.6,3996,3507.6,3644.3,3872.2,3459.9,0.9967020152326812,-0.004765849445040441,0.9574305281764095,0.018892728925114392,0.9728708091813397,0.01194482734192769,7193]
["P49840","Glycogen synthase kinase-3 alpha [OS=Homo sapiens]",35,10,22,7,483,50.9,8.75,54.73,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function","GSK3A","ENSG00000105723","Chemokine signaling pathway; Dopaminergic synapse; Non-alcoholic fatty liver disease; Shigellosis","XBP1(S) activates chaperone genes; Constitutive Signaling by AKT1 E17K in Cancer; AKT phosphorylates targets in the cytosol; Suppression of apoptosis; Maturation of nucleoprotein; Maturation of nucleoprotein","IL-5 signaling pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; Wnt signaling pathway; Regulation of apoptosis by parathyroid hormone-related protein; Angiopoietin-like protein 8 regulatory pathway; Nonalcoholic fatty liver disease; Insulin signaling; Glycogen synthesis and degradation",1611.2,1631,1632.2,1435.5,1391.3,1338.7,1.1701836514223982,0.22673496758994457,1.2016302962023734E-3,2.9202291305166335,0.04104072820066891,1.3867849419818514,214]
["P49916-1","DNA ligase 3 [OS=Homo sapiens]",32,28,62,28,1009,112.8,9.01,209.66,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","LIG3","ENSG00000005156","Base excision repair","HDR through MMEJ (alt-NHEJ); Gap-filling DNA repair synthesis and ligation in TC-NER; Gap-filling DNA repair synthesis and ligation in GG-NER; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; Resolution of AP sites via the single-nucleotide replacement pathway","Base excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum",7498.1,7642,7812.5,7530.7,7751.9,9904.9,0.9112694789081884,-0.13405034668356952,0.38397869815829916,0.4156928681556853,0.5700792819092034,0.24406474204446799,4923]
["P50336","protoporphyrinogen oxidase [OS=Homo sapiens]",31,11,24,11,477,50.7,8.16,62.92,"other metabolic processes;other biological processes","other membranes;mitochondrion","other molecular function","PPOX","ENSG00000143224","Porphyrin and chlorophyll metabolism; Metabolic pathways; Biosynthesis of cofactors","Heme biosynthesis","Orexin receptor pathway; Heme biosynthesis",1738.9,1659.7,1731.1,1556,1514.5,2134.4,0.9855520759284523,-0.020995990540172944,0.9070710565921019,0.042358690583662054,0.9406615142780466,0.026566624103680606,7048]
["P50443","sulfate transporter [OS=Homo sapiens]",1,1,1,1,739,81.6,8.38,2.85,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes","transporter activity","SLC26A2","ENSG00000155850","Chemical carcinogenesis","Transport and synthesis of PAPS; Multifunctional anion exchangers; Defective SLC26A2 causes chondrodysplasias","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Proteoglycan biosynthesis",36.3,39.8,31.6,45.2,45.3,71.4,0.6652254478072884,-0.5880847357583584,0.11615443331409898,0.9349642096510364,0.34765469004617094,0.4588519073759271,2442]
["P50570-1","Dynamin-2 [OS=Homo sapiens]",44,37,151,2,870,98,7.44,464.51,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","DNM2","ENSG00000079805; ENSGGOG00000005968; ENSPTRG00000034439","Phospholipase D signaling pathway; Endocytosis; Fc gamma R-mediated phagocytosis; Synaptic vesicle cycle; Endocrine and other factor-regulated calcium reabsorption; Bacterial invasion of epithelial cells; Salmonella infection","MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Recycling pathway of L1; Clathrin-mediated endocytosis; NGF-stimulated transcription; Toll Like Receptor 4 (TLR4) Cascade; NOSTRIN mediated eNOS trafficking; Retrograde neurotrophin signalling; Formation of annular gap junctions","Synaptic vesicle pathway; Fragile X syndrome; Intracellular trafficking proteins involved in CMT neuropathy",18917.8,18685.5,19201.6,16611.5,16131.8,18262,1.1137058305705485,0.15536821578272125,0.04326890984432058,1.3638240466677,0.2170572834949479,0.6634256365537173,1457]
["P50579-2","Isoform 2 of Methionine aminopeptidase 2 [OS=Homo sapiens]",35,13,57,1,455,50.5,5.35,180.07,"","","","METAP2","","","","",72.4,67.6,77,83.8,88.2,93.6,0.8170180722891565,-0.29156010401508337,0.01450879712969897,1.8383685918068333,0.1254968026283666,0.9013673388725527,845]
["P50897","Palmitoyl-protein thioesterase 1 [OS=Homo sapiens]",20,5,15,5,306,34.2,6.52,51.73,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PPT1","ENSG00000131238","Fatty acid elongation; Metabolic pathways; Fatty acid metabolism; Lysosome","Fatty acyl-CoA biosynthesis","",1297.3,1356.7,1338.3,1611.1,1493.8,1505.9,0.8658584193632343,-0.20779695259264996,0.00745465618354194,2.127572381860056,0.09126646908795316,1.039688751105452,597]
["P50914","60S ribosomal protein L14 [OS=Homo sapiens]",29,6,40,6,215,23.4,10.93,109.32,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","other molecular function","RPL14","ENSG00000188846","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",4800.6,5094.7,4631.1,5218,5207.7,6522.8,0.8570905979880226,-0.22248038371207254,0.15215310007047558,0.8177191946052863,0.39102918720643676,0.407790824779042,2844]
["P51151","Ras-related protein Rab-9A [OS=Homo sapiens]",47,7,8,7,201,22.8,5.47,21.06,"transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","RAB9A","ENSG00000123595","Salmonella infection; Measles","RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Retrograde transport at the Trans-Golgi-Network; RHOBTB3 ATPase cycle","Ebola virus pathway in host",724.8,753.3,765.2,673.1,749.6,1054.9,0.9054326767839845,-0.14332072094628087,0.5417676009450578,0.26618697042042955,0.679907176392072,0.1675503748414374,5824]
["P51532-4","Isoform 4 of Transcription activator BRG1 [OS=Homo sapiens]",22,35,82,18,1617,181.6,8.07,239.68,"","","","SMARCA4","","","","",3671.9,3676.4,3661.9,4220.1,4276.1,4964.5,0.8179515181231288,-0.2899127610555241,0.02697234628966151,1.5690812731862727,0.1705370925874879,0.7681811453868099,1156]
["P51571","translocon-associated protein subunit delta [OS=Homo sapiens]",36,5,27,5,173,19,6.15,88.66,"","other membranes;ER/Golgi;other cell component","","SSR4","ENSG00000180879","Protein processing in endoplasmic reticulum","SRP-dependent cotranslational protein targeting to membrane","VEGFA-VEGFR2 signaling pathway",3787.5,4174.8,3957.2,4479.7,3627.5,4815.3,0.922383439736893,-0.11656148348476505,0.4183117233698747,0.3784999639551074,0.5927569573692156,0.22712333987305314,5158]
["P51648","Fatty aldehyde dehydrogenase [OS=Homo sapiens]",14,7,18,7,485,54.8,7.88,52.73,"other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ALDH3A2","ENSG00000072210","Glycolysis / Gluconeogenesis; Ascorbate and aldarate metabolism; Fatty acid degradation; Valine, leucine and isoleucine degradation; Lysine degradation; Arginine and proline metabolism; Histidine metabolism; Tryptophan metabolism; beta-Alanine metabolism; Glycerolipid metabolism; Pyruvate metabolism; Pantothenate and CoA biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Alcoholic liver disease","RND2 GTPase cycle; RND1 GTPase cycle","Fragile X syndrome; Tryptophan metabolism; Fluoroacetic acid toxicity",1700.1,1707.9,1714.1,1589.3,1572.7,1107,1.19983602717264,0.26283725670980174,0.14651575704166328,0.834115666584572,0.38396689430531267,0.41570621896664883,2789]
["P51692","Signal transducer and activator of transcription 5B [OS=Homo sapiens]",10,8,12,8,787,89.8,6.05,26.85,"other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","STAT5B","ENSG00000173757","ErbB signaling pathway; Chemokine signaling pathway; Necroptosis; JAK-STAT signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; Prolactin signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Hepatitis B; Measles; Human T-cell leukemia virus 1 infection; Pathways in cancer; Viral carcinogenesis; Chemical carcinogenesis; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer","Interleukin-3, Interleukin-5 and GM-CSF signaling; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Growth hormone receptor signaling; Signaling by Leptin; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Signaling by cytosolic FGFR1 fusion mutants; Prolactin receptor signaling; Interleukin-20 family signaling; Erythropoietin activates STAT5; Signaling by FLT3 fusion proteins; Interleukin-2 signaling; STAT5 activation downstream of FLT3 ITD mutants; Interleukin-15 signaling; Interleukin-9 signaling; Interleukin-21 signaling; STAT5 Activation","IL-5 signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; AGE/RAGE pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Chemokine signaling pathway; IL-4 signaling pathway; White fat cell differentiation; Non-small cell lung cancer; EGF/EGFR signaling pathway; Hepatitis B infection; Endochondral ossification; Endochondral ossification with skeletal dysplasias; IL-2 signaling pathway; 3q29 copy number variation syndrome; FOXP3 in COVID-19; Familial partial lipodystrophy (FPLD); EPO receptor signaling; ErbB signaling pathway",1389.8,1438,1362.4,1425.5,1253.5,2078.6,0.8807381873213386,-0.18321487482049867,0.4951392794359024,0.3052726196882954,0.6454383794180508,0.19014521390281688,5607]
["P51795-2","Isoform 2 of H(+)/Cl(-) exchange transporter 5 [OS=Homo sapiens]",4,5,9,4,816,90.7,6.19,13.15,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","CLCN5","ENSG00000171365; ENSPPAG00000029912; ENSPTRG00000021899","Neutrophil extracellular trap formation","Stimuli-sensing channels","",777.8,772.2,815.6,820.8,782.3,1491.8,0.7643542602345795,-0.38768664638245315,0.35154158144438713,0.45402329788799434,0.5554296192773509,0.25537096443862206,4626]
["P51946","Cyclin-H [OS=Homo sapiens]",5,2,3,2,323,37.6,7.15,2.43,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","enzyme regulator activity","CCNH","ENSG00000134480","Basal transcription factors; Nucleotide excision repair; Cell cycle","RUNX1 regulates transcription of genes involved in differentiation of HSCs; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Formation of Incision Complex in GG-NER; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry","Cell cycle; Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum",255.4,287.7,263.1,285.1,349.3,195.6,0.9713253012048193,-0.04197355327056987,0.870393410299582,0.06028440565297535,0.9160123017825261,0.0380986938426368,6945]
["P51948-1","CDK-activating kinase assembly factor MAT1 [OS=Homo sapiens]",20,4,5,4,309,35.8,6.09,14,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","nucleus","enzyme regulator activity;kinase activity;other molecular function","MNAT1","ENSCANG00000033478; ENSCATG00000030975; ENSCSAG00000014164; ENSG00000020426; ENSMFAG00000000901; ENSMMUG00000001642; ENSNLEG00000013781; ENSPPAG00000033622; ENSPTRG00000006412; ENSRROG00000035712","Basal transcription factors; Nucleotide excision repair","RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of Incision Complex in GG-NER; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry","Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; Eukaryotic transcription initiation; G1 to S cell cycle control",193.2,194.4,165.5,215.9,220.4,250.3,0.8055636469560151,-0.31192951524133145,0.03611040379670591,1.4423676551428029,0.19740534132395174,0.7046411005208142,1337]
["P52272","Heterogeneous nuclear ribonucleoprotein M [OS=Homo sapiens]",64,43,419,43,730,77.5,8.7,1152.55,"RNA metabolism OR transcription;other metabolic processes;stress response","nucleus;other cell component","nucleic acid binding activity;other molecular function","HNRNPM","ENSG00000099783","Spliceosome","mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA","mRNA processing",51877.2,50382.2,52990.4,52427.7,50947.1,50203.6,1.0108830408442853,0.015616087097545658,0.6068348231595153,0.21692950522202242,0.7230772289652588,0.14081531498451613,6134]
["P52429","Diacylglycerol kinase epsilon [OS=Homo sapiens]",8,6,11,6,567,63.9,7.74,27.76,"other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","DGKE","ENSG00000153933","Glycerolipid metabolism; Glycerophospholipid metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Phospholipase D signaling pathway; Choline metabolism in cancer","Effects of PIP2 hydrolysis","Ciliary landscape",1767.9,1834.8,1922,1676.9,1800.3,1397.8,1.1332717948717947,0.1804939071326534,0.16370378986909553,0.7859412662191946,0.40491065995032804,0.39264078955249576,2955]
["P52565-1","rho GDP-dissociation inhibitor 1 [OS=Homo sapiens]",40,9,172,9,204,23.2,5.11,548.54,"signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","ARHGDIA; HEL-S-47e","ENSCATG00000044701; ENSG00000141522; ENSGGOG00000011564; ENSMLEG00000000660; ENSMMUG00000009949; ENSMNEG00000037888; ENSPPAG00000035710; ENSPPYG00000008748; ENSPTRG00000009773; ENSRBIG00000034513; ENSRROG00000034509","Neurotrophin signaling pathway; Vasopressin-regulated water reabsorption","CDC42 GTPase cycle; RAC1 GTPase cycle; RHOC GTPase cycle; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOH GTPase cycle; Axonal growth stimulation; Axonal growth inhibition (RHOA activation)","Ciliary landscape; Nephrotic syndrome",31073.2,31819.1,31219.5,28457.1,27496.4,17242,1.2857593704531016,0.3626206679092768,0.12455960882413437,0.9046227643271122,0.35927631448129366,0.4445714129905618,2534]
["P52739","Zinc finger protein 131 [OS=Homo sapiens]",10,5,6,5,623,71.4,5.19,18.71,"other biological processes","cytoskeleton;nucleus","nucleic acid binding activity;other molecular function","ZNF131","ENSG00000172262","","SUMOylation of transcription cofactors","",291.2,289.9,303,293.3,339.5,332.8,{"$f":"AVERAGE(S2114:U2114)/AVERAGE(V2114:X2114)","v":0.9155965202982602},{"$f":"LOG(Y2114,2)","v":-0.127216114909865},{"$f":"TTEST(V2114:X2114,S2114:U2114,2,2)","v":0.14444022858477543},0.8403118329492537,{"$f":"AA2114*7309/AE2114","v":0.38181324800221467},0.41814900670599786,2765]
["P52815","39S ribosomal protein L12, mitochondrial [OS=Homo sapiens]",39,5,53,5,198,21.3,8.87,149.17,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL12","ENSG00000262814","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",3579.8,4549.4,3244.8,3429.4,4231.8,3108.5,1.0561111265866272,0.07876164657176238,0.7153285548714416,0.14549443820794497,0.8005414802565254,0.09661616008472876,6531]
["P52907","F-actin-capping protein subunit alpha-1 [OS=Homo sapiens]",69,14,178,11,286,32.9,5.69,709.15,"cell organization and biogenesis","non-structural extracellular;cytosol;cytoskeleton;other cell component","cytoskeletal activity","CAPZA1","ENSG00000116489","Endocytosis","MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Sensory processing of sound by inner hair cells of the cochlea; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Factors involved in megakaryocyte development and platelet production; Advanced glycosylation endproduct receptor signaling","",15779.4,15793.5,16336.8,15009.1,14704.6,16070,1.0464357402306936,0.06548372096109185,0.19252670230171198,0.7155090279318098,0.438646404963595,0.35788542565996273,3208]
["P53365","Arfaptin-2 [OS=Homo sapiens]",23,4,6,3,341,37.8,6.04,24.62,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","ARFIP2","ENSG00000132254","","Retrograde transport at the Trans-Golgi-Network","",471.4,480.6,471,423.4,474.8,216.9,1.2761187337458522,0.3517625678309306,0.26305768908545296,0.5799489994034922,0.5013529724968907,0.29985640580451894,3835]
["P53370","Nucleoside diphosphate-linked moiety X motif 6 [OS=Homo sapiens]",3,1,2,1,316,35.7,8,4.1,"other biological processes","mitochondrion;nucleus;other cell component","other molecular function","NUDT6","ENSG00000170917","","","",133.8,155.8,145.4,128.2,127.2,96.3,1.236849587716804,0.30667006599814595,0.08600463935462267,1.0654781209451794,0.3012016813813786,0.5211426081266605,2087]
["P53621-1","coatomer subunit alpha [OS=Homo sapiens]",54,57,294,57,1224,138.3,7.66,894.15,"transport;signal transduction","non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","COPA","ENSG00000122218","","COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic","",33205.9,33988.2,33802.5,32776.4,32277.1,28380.5,1.0809405569706958,0.1122871886400436,0.14820670229409807,0.8291321559820239,0.38590765481566186,0.41351660673249013,2807]
["P53701","Cytochrome c-type heme lyase [OS=Homo sapiens]",65,16,41,16,268,30.6,6.68,118.25,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes","other membranes;mitochondrion","other molecular function","HCCS","ENSG00000004961","Porphyrin and chlorophyll metabolism; Metabolic pathways","","",3717.5,3830.4,3659,4182.2,4152.7,4524.2,0.8715151138104534,-0.19840241110975687,0.013094316773950213,1.8829171569595766,0.11963295162600263,0.9221491820675474,800]
["P53801","pituitary tumor-transforming gene 1 protein-interacting protein [OS=Homo sapiens]",8,2,6,2,180,20.3,8.79,13.57,"transport;other biological processes","other membranes;nucleus;other cell component","other molecular function","PTTG1IP","ENSG00000183255","","","",994,910.9,965.6,781.5,865.6,472.3,1.3543927526658488,0.43764615852855077,0.1094919702257176,0.9606177293583981,0.33809751177852554,0.4709580254035079,2367]
["P54105","Methylosome subunit pICln [OS=Homo sapiens]",35,5,13,5,237,26.2,4.11,50.27,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","","CLNS1A","ENSG00000074201","","snRNP Assembly","",534.5,539.4,497.9,615,667.2,974.6,0.6964728819567529,-0.5218609141041278,0.11328638701058864,0.9458222737321724,0.34328781204825554,0.4643416153163131,2412]
["P54274-1","telomeric repeat-binding factor 1 [OS=Homo sapiens]",3,1,1,1,439,50.2,6.37,2.11,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","TERF1","ENSG00000147601","","Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Meiotic synapsis; Inhibition of DNA recombination at telomere; Packaging Of Telomere Ends; DNA Damage/Telomere Stress Induced Senescence; Telomere Extension By Telomerase; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; Removal of the Flap Intermediate from the C-strand","",61.5,63.1,66.4,87.5,86.9,61.5,0.8096651123357353,-0.30460278031635174,0.16008429263289864,0.7956512786835298,0.3998824657737034,0.3980676385888489,2926]
["P54296","Myomesin-2 [OS=Homo sapiens]",6,7,9,7,1465,164.8,6.19,23.9,"cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYOM2","ENSG00000036448; ENSG00000274137","","","",355.1,333.9,366.7,390.1,376,386.4,0.9160086767895879,-0.12656683073324185,0.037071406965349524,1.4309609309466413,0.20026231597172187,0.6984007656602914,1353]
["P54802","alpha-N-acetylglucosaminidase [OS=Homo sapiens]",19,10,20,10,743,82.2,6.65,57.38,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;other cytoplasmic organelle","other molecular function","NAGLU","ENSG00000108784","Glycosaminoglycan degradation; Metabolic pathways; Lysosome","HS-GAG degradation; MPS IIIB - Sanfilippo syndrome B","Glycosaminoglycan degradation",1724.9,1694.9,1759.9,1615,1596.3,1945.3,1.0044796959236706,0.006448402412387999,0.9497819288648188,{"$f":"-LOG10(AA2179)","v":0.022376097829334973},0.96778978364324,{"$f":"-LOG10(AC2179)","v":0.01421896678079926},7173]
["P54852","Epithelial membrane protein 3 [OS=Homo sapiens]",10,1,3,1,163,18.4,7.96,10.84,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes","","EMP3","ENSG00000142227","","","",176.3,192.1,197.5,182.8,180.6,253.8,0.9168826960466623,-0.1251909244879675,0.5294970436744957,0.27613646033352635,0.6707268444050067,0.1734543116052848,5770]
["P55039","Developmentally-regulated GTP-binding protein 2 [OS=Homo sapiens]",35,11,41,10,364,40.7,8.88,108.5,"protein metabolism;other metabolic processes;signal transduction","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DRG2","ENSG00000108591","","","",4121.7,4193.4,4105.6,3781.7,3744.8,3507.2,1.1257057922546378,0.17082982251892298,6.844688903662936E-3,2.1646462860972444,0.08901749323286903,1.0505246397823327,562]
["P55145","Mesencephalic astrocyte-derived neurotrophic factor [OS=Homo sapiens]",25,6,18,6,182,20.7,8.69,39.71,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","MANF","ENSG00000145050","","Platelet degranulation","Orexin receptor pathway",1412.7,1829.4,1516.2,1561.8,1638.9,1445.8,1.0240611212740773,0.03430182542331462,0.7994419224093325,0.09721308125272446,0.8650068113826516,0.06298047272680092,6755]
["P55197-1","Isoform 1 of Protein AF-10 [OS=Homo sapiens]",3,3,3,2,1027,109,8.38,6.62,"","","","MLLT10","","","","",223.5,205.4,222.9,299.4,316.5,265,0.7399250766261778,-0.4345489012434058,0.009343082985561793,2.0295097937177453,0.10101862949921767,0.9955985277754084,676]
["P55209-3","Isoform 3 of Nucleosome assembly protein 1-like 1 [OS=Homo sapiens]",47,11,262,1,323,37.3,4.67,864.92,"","","","NAP1L1","","","","",22.1,28.4,23,12.9,18.7,41.5,1.0054719562243504,0.007872843771289635,0.9888244449219196,0.00488080584397763,0.9933092176930057,2.9155343514506516E-3,7276]
["P55769","NHP2-like protein 1 [OS=Homo sapiens]",38,5,20,5,128,14.2,8.46,56.04,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SNU13","ENSG00000100138","Ribosome biogenesis in eukaryotes; Spliceosome","mRNA Splicing - Major Pathway; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; mRNA Splicing - Minor Pathway","mRNA processing",2554.3,3171.4,2445.6,2783.5,3096.2,2835.1,0.9376348281085053,-0.09290193574343289,0.5020818985251891,0.2992254358898142,0.6510052503673244,0.1864155088260293,5637]
["P55795","heterogeneous nuclear ribonucleoprotein H2 [OS=Homo sapiens]",48,18,271,7,449,49.2,6.3,653.89,"other biological processes","cytosol;nucleus;other cell component","","HNRNPH2","ENSG00000126945","","mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA","mRNA processing",6927.5,6870.3,7138.3,6924.6,7277,5944.9,1.0391929119201846,0.055463495663180214,0.5528404242159461,0.25740020844853084,0.6868452593225141,0.1631410949520044,5883]
["P56181-2","Isoform 2 of NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [OS=Homo sapiens]",22,7,14,7,473,51,9.17,48.09,"","","","NDUFV3","","","","",2177.6,1213.7,967.7,2229,1452.9,1493.4,0.8422700133325604,-0.2476452909910821,0.5756830450997504,0.23981656110948565,0.7036233071294441,0.15265978321392354,5980]
["P56270-2","Isoform 2 of Myc-associated zinc finger protein [OS=Homo sapiens]",10,5,11,4,493,51,9.1,40.42,"","","","MAZ","","","","",820.3,837,846.7,943.9,1055.7,1098.9,0.8081329675649508,-0.3073354060389916,0.013344472919534832,1.874698575316578,0.12056211689601988,0.9187891350448772,809]
["P56937-1","3-keto-steroid reductase [OS=Homo sapiens]",21,6,13,6,341,38.2,8.1,39.26,"other metabolic processes","other membranes;ER/Golgi","other molecular function","HSD17B7","ENSG00000132196","Steroid biosynthesis; Steroid hormone biosynthesis; Metabolic pathways; Ovarian steroidogenesis","Cholesterol biosynthesis","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Steroid biosynthesis",1073.6,1188.7,1181.2,1161.9,1221.3,1879.9,0.807745537285074,-0.3080272201234063,0.30615229558599755,0.5140624797964541,0.5301272514660166,0.2756198700668893,4221]
["P57678","Gem-associated protein 4 [OS=Homo sapiens]",10,10,21,10,1058,120,6.04,54.82,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","GEMIN4","ENSG00000179409","","snRNP Assembly","",2115.1,2124,2110.7,2318.4,2202.4,2392.4,0.9185037319909737,-0.12264251169561272,0.027581547223181513,1.559381375156446,0.17274509739008884,0.7625942693178434,1167]
["P57737","Coronin-7 [OS=Homo sapiens]",52,34,178,1,925,100.5,5.8,561.51,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cell component","cytoskeletal activity","CORO7","ENSG00000262246; ENSG00000282725","","","",305.3,297.5,318.6,305.9,301.9,474.4,0.8514137867307338,-0.2320676433782404,0.40161234133314144,0.3961929500200831,0.5816097885484309,0.23536829286979596,5047]
["P58005-1","sestrin-3 [OS=Homo sapiens]",5,2,3,2,492,57.3,6.25,5.58,"stress response;signal transduction;other biological processes","nucleus;other cell component","other molecular function","SESN3","ENSG00000149212","p53 signaling pathway; Longevity regulating pathway","TP53 Regulates Metabolic Genes","Angiopoietin-like protein 8 regulatory pathway; miRNA regulation of p53 pathway in prostate cancer",132.5,130.8,135.9,97.3,104.8,164.7,1.0883315158124323,0.1221180817422067,0.6400110451676941,0.19381253099425425,0.7461861108838215,0.12715283894924012,6269]
["P60468","protein transport protein Sec61 subunit beta [OS=Homo sapiens]",36,4,39,4,96,10,11.56,58.02,"protein metabolism;other metabolic processes;stress response;transport","other membranes;cytosol;ER/Golgi","translation activity;other molecular function","SEC61B","ENSG00000106803","Protein export; Protein processing in endoplasmic reticulum; Phagosome; Vibrio cholerae infection","ER-Phagosome pathway; SRP-dependent cotranslational protein targeting to membrane; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",4788.7,4614.7,4891.1,4022.2,4432.7,3268.9,1.2192719084255959,0.28601989559952856,0.07068347900157342,1.1506820829060467,0.2713369474908089,0.5664910650705293,1904]
["P60520","Gamma-aminobutyric acid receptor-associated protein-like 2 [OS=Homo sapiens]",35,5,6,5,117,13.7,8.1,15.85,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","GABARAPL2","ENSG00000034713","FoxO signaling pathway; Autophagy; Mitophagy; Autophagy; NOD-like receptor signaling pathway; GABAergic synapse","TBC/RABGAPs; Macroautophagy","Network map of SARS-CoV-2 signaling pathway; Senescence and autophagy in cancer",762,771.5,769.8,1131.2,1150,1962.8,0.5427191328934967,-0.8817223248766557,0.07768175818576845,1.1096809535205419,0.2860332345490083,0.5435835027357028,1985]
["P60891","ribose-phosphate pyrophosphokinase 1 [OS=Homo sapiens]",58,17,100,8,318,34.8,6.98,299.06,"other metabolic processes;developmental processes","cytosol;other cell component","kinase activity;other molecular function","PRPS1","ENSG00000147224","Pentose phosphate pathway; Purine metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids","5-Phosphoribose 1-diphosphate biosynthesis","Nucleotide metabolism",14676,14400.6,14273.7,12683.6,11950.9,10499,1.2338736533507906,0.3031946724318203,0.013745046747790325,1.861853778754463,0.12281484924156416,0.910749120541813,818]
["P60953","Cell division control protein 42 homolog [OS=Homo sapiens]",48,8,143,2,191,21.2,6.55,517.75,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","CDC42","ENSG00000070831","MAPK signaling pathway; Ras signaling pathway; Rap1 signaling pathway; Chemokine signaling pathway; Endocytosis; Axon guidance; VEGF signaling pathway; Focal adhesion; Adherens junction; Tight junction; T cell receptor signaling pathway; Fc gamma R-mediated phagocytosis; Leukocyte transendothelial migration; Neurotrophin signaling pathway; Regulation of actin cytoskeleton; GnRH signaling pathway; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Bacterial invasion of epithelial cells; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Human papillomavirus infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; Renal cell carcinoma; Pancreatic cancer; Lipid and atherosclerosis","RHO GTPases Activate Formins; MAPK6/MAPK4 signaling; RHO GTPases activate IQGAPs; RAC1 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; GPVI-mediated activation cascade; CDC42 GTPase cycle; RHOG GTPase cycle; RAC3 GTPase cycle; RHOQ GTPase cycle; RAC2 GTPase cycle; RHOJ GTPase cycle; EPHB-mediated forward signaling; DCC mediated attractive signaling; Myogenesis; G beta:gamma signalling through CDC42; EGFR downregulation; RHO GTPases activate PAKs; Inactivation of CDC42 and RAC1; CD28 dependent Vav1 pathway; RHO GTPases activate KTN1","Androgen receptor signaling pathway; Target of rapamycin (TOR) signaling; Integrin-mediated cell adhesion; Integrated breast cancer pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; Microtubule cytoskeleton regulation; Metastatic brain tumor; Pathogenic Escherichia coli infection; RalA downstream regulated genes; B cell receptor signaling pathway; AGE/RAGE pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Focal adhesion; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; Oxidative damage response; p38 MAPK signaling pathway; Ebola virus pathway in host; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Hippo signaling regulation pathways; 22q11.2 copy number variation syndrome; Gastrin signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent)",13637.9,13358.4,13200.9,11551.8,12429.2,6408.7,1.3227244757269732,0.403512578699775,0.15739355626037416,0.8030130517599712,0.39682287088895296,0.40140330523099566,2899]
["P61020","Ras-related protein Rab-5B [OS=Homo sapiens]",66,9,33,6,215,23.7,8.13,109.45,"transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","RAB5B","ENSG00000111540","Ras signaling pathway; Endocytosis; Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection; Amoebiasis; Tuberculosis","RAB geranylgeranylation; Neutrophil degranulation; Clathrin-mediated endocytosis; RAB GEFs exchange GTP for GDP on RABs; TBC/RABGAPs","Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells",1144.1,1205.3,1381.3,1114.8,1176.2,1743.8,0.9246307127986516,-0.11305081054581942,0.6581933095458037,0.1816465365693063,0.7580735738213487,0.12028864244972681,6346]
["P61160-1","Actin-related protein 2 [OS=Homo sapiens]",36,11,110,11,394,44.7,6.74,332.6,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","Actr2; ACTR2; LOC111147990","ENSAMEG00000015749; ENSANAG00000038066; ENSBIXG00000015264; ENSBIXG00005008678; ENSBTAG00000009761; ENSCAFG00000003197; ENSCATG00000036025; ENSCCAG00000030047; ENSCHIG00000014272; ENSCJAG00000006722; ENSCPOG00000025808; ENSDLEG00000013424; ENSECAG00000009219; ENSFCAG00000004960; ENSG00000138071; ENSHGLG00000013085; ENSLAFG00000010273; ENSLCNG00005006073; ENSMFAG00000044097; ENSMLEG00000038155; ENSMLUG00000005227; ENSMMUG00000002263; ENSMNEG00000044163; ENSMPUG00000006176; ENSMUSG00000020152; ENSNLEG00000009948; ENSOANG00000039143; ENSOCUG00000004906; ENSPANG00000007073; ENSPCOG00000025808; ENSPCTG00005007920; ENSPPAG00000030634; ENSPPYG00000012359; ENSPTRG00000011990; ENSRBIG00000040326; ENSRFEG00010007536; ENSRROG00000043956; ENSSBOG00000028028; ENSSSUG00005000856; ENSSTOG00000012608; ENSTSYG00000034470; ENSVURG00010013014; ENSVVUG00000027598","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Salmonella infection; Yersinia infection; Pathogenic Escherichia coli infection; Shigellosis","Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; EPHB-mediated forward signaling; Regulation of actin dynamics for phagocytic cup formation; Neutrophil degranulation; EPHB-mediated forward signaling; Clathrin-mediated endocytosis; RHO GTPases Activate WASPs and WAVEs","ESC pluripotency pathways; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways",14430.7,14606.7,14276,13217.8,13253.1,13396.9,1.0864256367293905,0.11958942882816892,4.7738660598579258E-4,3.3211297701387803,0.025468749658030348,1.5939923754112142,137]
["P61201-1","COP9 signalosome complex subunit 2 [OS=Homo sapiens]",44,17,60,1,443,51.6,5.53,181.37,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","Cops2; COPS2; LOC101356833; LOC111162519","ENSACCG00020011181; ENSANAG00000033255; ENSBIXG00000019496; ENSBIXG00005014970; ENSCHIG00000021490; ENSCPOG00000003447; ENSCSAG00000010648; ENSDLEG00000002228; ENSG00000166200; ENSGALG00000000404; ENSLSDG00000017105; ENSMMUG00000009838; ENSMPUG00000012327; ENSMUSG00000027206; ENSOARG00000021006; ENSPPYG00000006460; ENSPSIG00000010252; ENSRNOG00000008744; ENSSHBG00005020299; ENSSSCG00000004652; ENSSSCG00070002171; ENSSTOG00000005348; ENSUMAG00000014609","","Cargo recognition for clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER; Formation of TC-NER Pre-Incision Complex; RHOBTB1 GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; Neddylation; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER; RHOBTB1 GTPase cycle; Neddylation; DNA Damage Recognition in GG-NER; Formation of TC-NER Pre-Incision Complex; Cargo recognition for clathrin-mediated endocytosis; RHOBTB1 GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; Neddylation; Formation of TC-NER Pre-Incision Complex; RHOBTB1 GTPase cycle; DNA Damage Recognition in GG-NER","Ciliary landscape",5516.5,5267.3,5496.2,5809.3,5670.5,4886.1,0.9947512816282637,-0.007592242212331328,0.9281479792298339,0.03238277654028379,0.9546627610738609,0.02015001780961998,7106]
["P61313-1","60S ribosomal protein L15 [OS=Homo sapiens]",50,12,68,12,204,24.1,11.62,207.71,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;cytoskeleton;translational apparatus;nucleus","nucleic acid binding activity;other molecular function","LOC111155115; NR1D2; Rpl15; RPL15","ENSAMEG00000003497; ENSAMEG00000024645; ENSBIXG00000012476; ENSBIXG00005007092; ENSBMUG00000012295; ENSBTAG00000033080; ENSCAFG00000005764; ENSCAFG00030022972; ENSCAFG00040022162; ENSCANG00000040764; ENSCATG00000039291; ENSCGRG00001021972; ENSCGRG00015016653; ENSCJAG00000043224; ENSCPOG00000030042; ENSCSAG00000009762; ENSECAG00000010157; ENSFCAG00000026237; ENSG00000174748; ENSGGOG00000024274; ENSHGLG00000000795; ENSLCNG00005011910; ENSMFAG00000043886; ENSMLEG00000031741; ENSMLUG00000013809; ENSMMUG00000006353; ENSMPUG00000012148; ENSMUSG00000012405; ENSNLEG00000003580; ENSOANG00000045456; ENSOCUG00000010961; ENSOGAG00000013056; ENSPANG00000015926; ENSPPAG00000032386; ENSPPYG00000014065; ENSPTRG00000014695; ENSRBIG00000024014; ENSRBIG00000033415; ENSRFEG00010011144; ENSRNOG00000008140; ENSRROG00000001983; ENSRROG00000015533; ENSRROG00000027506; ENSRROG00000028991; ENSRROG00000037650; ENSSHAG00000031281; ENSSSCG00000037030; ENSSSCG00070018008; ENSSSUG00005002593; ENSSTOG00000011153; ENSUAMG00000015536; ENSVURG00010022414; ENSVVUG00000028235","Ribosome; Coronavirus disease","L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Formation of a pool of free 40S subunits; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins; Cytoplasmic ribosomal proteins; Cytoplasmic ribosomal proteins",11918.3,11260.6,11421,12974.8,14214.9,14247.5,0.8349960904694333,-0.260158652119313,0.007935820690311759,2.1004081536169723,0.09416057374267636,1.0261309038974251,616]
["P61626","lysozyme c [OS=Homo sapiens]",6,1,1,1,148,16.5,9.16,2.6,"other metabolic processes;stress response;other biological processes","non-structural extracellular;other cytoplasmic organelle;other cell component","other molecular function","LYZ","ENSG00000090382","Salivary secretion","Neutrophil degranulation; Amyloid fiber formation; Antimicrobial peptides","Macrophage markers",325,69.8,137.6,182,101.8,59.1,1.5526392534266549,0.6347226669762572,0.4957841425993449,0.3047073680315611,0.6460485466676077,0.18973484615710492,5609]
["P61769","Beta-2-microglobulin [OS=Homo sapiens]",8,1,2,1,119,13.7,6.52,6.3,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","B2M","ENSG00000166710; ENSG00000273686","Antigen processing and presentation; Human cytomegalovirus infection; Human T-cell leukemia virus 1 infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection","ER-Phagosome pathway; Neutrophil degranulation; DAP12 signaling; Amyloid fiber formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Modulation by Mtb of host immune system; Nef mediated downregulation of MHC class I complex cell surface expression; Endosomal/Vacuolar pathway","IL-18 signaling pathway",144.6,183.1,190.1,195.3,155.6,152.7,1.028196981731533,0.04011668218109481,0.8221200362680564,0.08506476727396826,0.8788760194651491,0.056072385290033284,6837]
["P61962","DDB1- and CUL4-associated factor 7 [OS=Homo sapiens]",17,5,9,5,342,38.9,5.52,25.48,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","DCAF7","ENSG00000136485","","Neddylation; Association of TriC/CCT with target proteins during biosynthesis","Ciliary landscape",1028.3,1005.1,1074.1,945.7,1042,1795.7,0.8213511656182269,-0.2839289221197037,0.45017208486280896,0.3466214390687754,0.6153558571651899,0.2108736612851431,5347]
["P61970","nuclear transport factor 2 [OS=Homo sapiens]",74,6,40,6,127,14.5,5.38,113.91,"transport;other biological processes","other membranes;cytosol;nucleus","other molecular function","NUTF2","ENSG00000102898","","","",6596.7,6593.2,6339.7,5978.4,6305.2,5754.3,1.0826980967851025,0.1146310130376218,0.051665496672195894,1.2867993912828386,0.23338882272996278,0.6319199466751191,1618]
["P62136-1","serine/threonine-protein phosphatase PP1-alpha catalytic subunit [OS=Homo sapiens]",59,15,107,4,330,37.5,6.33,384.55,"cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","LOC111149674; Ppp1ca; PPP1CA","ENSAMEG00000000758; ENSANAG00000023829; ENSBIXG00000010347; ENSBIXG00005003445; ENSBTAG00000012146; ENSCAFG00000041420; ENSCATG00000031120; ENSCCAG00000020614; ENSCHIG00000012800; ENSCJAG00000000983; ENSCPOG00000032835; ENSCSAG00000008548; ENSECAG00000010532; ENSFCAG00000028502; ENSG00000172531; ENSGGOG00000009981; ENSHGLG00000013028; ENSLCNG00005013643; ENSMLUG00000005112; ENSMMUG00000017278; ENSMNEG00000042253; ENSMPUG00000003801; ENSNLEG00000006360; ENSOARG00000011318; ENSOGAG00000033516; ENSPANG00000009836; ENSPCOG00000026258; ENSPCTG00005022585; ENSPPYG00000002995; ENSRFEG00010000614; ENSRNOG00000018708; ENSSHAG00000030720; ENSSSCG00000012913; ENSSSCG00070006658; ENSVURG00010024750; ENSVVUG00000010423","mRNA surveillance pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Oocyte meiosis; Cellular senescence; Adrenergic signaling in cardiomyocytes; Vascular smooth muscle contraction; Hippo signaling pathway; Focal adhesion; Platelet activation; Long-term potentiation; Dopaminergic synapse; Inflammatory mediator regulation of TRP channels; Regulation of actin cytoskeleton; Insulin signaling pathway; Oxytocin signaling pathway; Insulin resistance; Amphetamine addiction; Alcoholism; Herpes simplex virus 1 infection; Proteoglycans in cancer; Diabetic cardiomyopathy","DARPP-32 events; Circadian Clock; Triglyceride catabolism; Downregulation of TGF-beta receptor signaling; DARPP-32 events; DARPP-32 events","Sphingolipid pathway; Nicotine effect on dopaminergic neurons; Common pathways underlying drug addiction; Vascular smooth muscle contraction; Focal adhesion; VEGFA-VEGFR2 signaling pathway; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Netrin-UNC5B signaling pathway; Neuroinflammation and glutamatergic signaling",3174.7,3035.1,3156.9,3137.1,3261,2542.7,1.0476355583392984,0.0671369328893113,0.5639516577085274,0.2487581224178044,0.6946280192436175,0.15824770251465453,5934]
["P62256","ubiquitin-conjugating enzyme E2 H [OS=Homo sapiens]",28,6,8,6,183,20.6,4.67,23.56,"protein metabolism;other metabolic processes","cytosol;nucleus","other molecular function","UBE2H","ENSG00000186591","Ubiquitin mediated proteolysis","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation","Ciliary landscape",1552.6,1475.1,1520.2,1962.5,1783.9,832,0.993338284116722,-0.009642979644949872,0.9783168394710244,0.009520471030853033,0.9862783144405128,6.0005157178737376E-3,7250]
["P62266","40S ribosomal protein S23 [OS=Homo sapiens]",52,7,57,7,143,15.8,10.49,177.3,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytosol;ER/Golgi;translational apparatus;nucleus;other cell component","other molecular function","RPS23","ENSG00000186468","Ribosome; Coronavirus disease","Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",8261.2,8624.3,7913,8889.7,8621.3,8194.3,0.9647232282836614,-0.05181299131990572,0.353728335437454,0.4513301495965238,0.5565985799165449,0.25445790604221147,4645]
["P62312","U6 snRNA-associated Sm-like protein LSm6 [OS=Homo sapiens]",43,4,6,4,80,9.1,9.58,13.28,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","LSM6","ENSG00000164167","RNA degradation; Spliceosome","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease","",1317.7,1539.8,1313.7,1337.1,1379.1,1448.8,1.0014885954381751,2.1459923952838623E-3,0.9809844683746564,0.008337868616564817,0.9881498731188483,0.00517718078463071,7256]
["P62487","DNA-directed RNA polymerase II subunit rpb7 [OS=Homo sapiens]",38,5,9,5,172,19.3,5.54,24.31,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POLR2G","ENSG00000168002","RNA polymerase; Huntington disease","FGFR2 alternative splicing; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere","Pyrimidine metabolism; Eukaryotic transcription initiation",820.2,831,861.8,996.7,965.9,1294.6,0.7715215522534692,-0.37422163621850196,0.07849477390207835,1.1051592571533913,0.28772231817968436,0.5410264492450552,1994]
["P62633-1","Cellular nucleic acid-binding protein [OS=Homo sapiens]",50,9,54,1,177,19.5,7.71,136.79,"DNA metabolism;other metabolic processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","Cnbp; CNBP; LOC101344172; LOC111159043; LOC113917796","ENSAMEG00000015334; ENSBIXG00000009042; ENSBMUG00000014129; ENSCAFG00000004320; ENSCANG00000042967; ENSCATG00000020089; ENSCCAG00000034056; ENSCGRG00001000923; ENSCJAG00000017430; ENSCPOG00000032294; ENSCSAG00000008817; ENSDLEG00000010302; ENSECAG00000009512; ENSFCAG00000042197; ENSG00000169714; ENSHGLG00000002069; ENSLAFG00000002502; ENSLCNG00005005148; ENSMFAG00000030262; ENSMLEG00000041892; ENSMMUG00000058753; ENSMNEG00000028473; ENSMPUG00000017315; ENSNLEG00000035879; ENSOCUG00000008696; ENSPANG00000007815; ENSPCTG00005021559; ENSPPYG00000013423; ENSPTRG00000015369; ENSRBIG00000030361; ENSRNOG00000010239; ENSRROG00000045469; ENSSBOG00000023735; ENSSSCG00070013675; ENSSTOG00000000173; ENSTSYG00000004344; ENSTTRG00000015266; ENSVVUG00000018264","","","",4833.7,4671.2,5066.8,8275.2,7904.2,6269.5,0.6491053013733412,-0.6234755558833021,0.013810338854574972,1.8597956653122703,0.12294734066758645,0.910280860547738,821]
["P62753","40S RIBOSOMAL PROTEIN S6 [OS=Homo sapiens]",43,13,163,13,249,28.7,10.84,526.71,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;ER/Golgi;translational apparatus;nucleus;other cell component","other molecular function","RPS6","ENSG00000137154","EGFR tyrosine kinase inhibitor resistance; Ribosome; HIF-1 signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Apelin signaling pathway; Thermogenesis; Insulin signaling pathway; Coronavirus disease; Proteoglycans in cancer","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); mTORC1-mediated signalling; rRNA modification in the nucleus and cytosol; Nuclear events stimulated by ALK signaling in cancer","IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Thermogenesis; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Cytoplasmic ribosomal proteins; EGFR tyrosine kinase inhibitor resistance; IL-2 signaling pathway; Malignant pleural mesothelioma; Interferon type I signaling pathways",19093.1,18664,16792.1,18514.7,17848.3,17554.3,1.0117198005092984,0.016809785695529635,0.7957678746562091,0.09921359741023095,0.8620523782217626,0.06446634568155261,6747]
["P62826","GTP-binding nuclear protein RAN [OS=Homo sapiens]",66,10,91,10,216,24.4,7.49,277.36,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;other biological processes","cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RAN","ENSG00000132341","Ribosome biogenesis in eukaryotes; Nucleocytoplasmic transport; Human T-cell leukemia virus 1 infection","Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Nuclear import of Rev protein; Transcriptional regulation by small RNAs; tRNA processing in the nucleus; Regulation of cholesterol biosynthesis by SREBP (SREBF); MicroRNA (miRNA) biogenesis; Postmitotic nuclear pore complex (NPC) reformation","Androgen receptor signaling pathway; miRNA biogenesis; 22q11.2 copy number variation syndrome",13351.1,13704.3,12999.4,11756.3,11128.9,11932.9,1.1504016589072925,0.20213766129283747,0.005346533699169474,2.2719276914763267,0.08107430457931471,1.091116767831203,482]
["P62854","40S ribosomal protein S26 [OS=Homo sapiens]",21,2,7,2,115,13,11,24.57,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;translational apparatus;nucleus","nucleic acid binding activity;other molecular function","RPS26","ENSG00000197728","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Peptide chain elongation; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",795.3,911.6,602.5,719.6,669.4,815.8,1.0474419448476053,0.06687028382770367,0.7445452482913044,0.12810890370617878,0.8236538852370432,0.0842552486305237,6607]
["P62913","60S ribosomal protein L11 [OS=Homo sapiens]",49,8,53,8,178,20.2,9.6,142.44,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;translational apparatus;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","RPL11","ENSG00000142676","Ribosome; Coronavirus disease","Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",8615.7,9886.9,8266.7,9705.4,9531.4,4948.7,1.1068326063137004,0.14643705021173192,0.6258747643200844,0.20351255913129068,0.7369934996641689,0.13253634263271474,6207]
["P62937-2","Isoform 2 of Peptidyl-prolyl cis-trans isomerase A [OS=Homo sapiens]",90,12,899,1,105,11.4,7.9,1952.98,"","","","PPIA","","","","",724.6,832.1,737,461.9,292.7,159.7,2.508695176637865,1.3269371842308828,0.008035104621785442,2.095008464094377,0.0942673831149756,1.0256385488695736,623]
["P63027","Vesicle-associated membrane protein 2 [OS=Homo sapiens]",34,4,16,1,116,12.7,8.13,54.84,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","VAMP2","ENSG00000220205","SNARE interactions in vesicular transport; Synaptic vesicle cycle; Insulin secretion; Vasopressin-regulated water reabsorption; Salivary secretion","Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; GABA synthesis, release, reuptake and degradation; Cargo recognition for clathrin-mediated endocytosis; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Sensory processing of sound by inner hair cells of the cochlea; Lysosome Vesicle Biogenesis; trans-Golgi Network Vesicle Budding; Golgi Associated Vesicle Biogenesis; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; Regulation of insulin secretion; Insulin processing; Other interleukin signaling; Toxicity of tetanus toxin (tetX); Toxicity of botulinum toxin type B (botB); Toxicity of botulinum toxin type D (botD); Toxicity of botulinum toxin type G (botG); Toxicity of botulinum toxin type F (botF)","Synaptic vesicle pathway; Insulin signaling; 7q11.23 copy number variation syndrome; Galanin receptor pathway; Sudden infant death syndrome (SIDS) susceptibility pathways",1119.8,1122,1187.6,1288,1639.9,2775.2,0.601322087987235,-0.7337901417676861,0.1668972365023793,0.7775508543435432,0.4087975541541188,0.3884917112602014,2984]
["P63208","s-phase kinase-associated protein 1 [OS=Homo sapiens]",63,10,50,10,163,18.6,4.54,140.14,"protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","SKP1","ENSG00000113558","Cell cycle; Oocyte meiosis; Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum; Wnt signaling pathway; TGF-beta signaling pathway; Circadian rhythm; Shigellosis; Salmonella infection; Human immunodeficiency virus 1 infection; Pathways in cancer","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Regulation of RUNX2 expression and activity; Circadian Clock; Antigen processing: Ubiquitination & Proteasome degradation; Nuclear events stimulated by ALK signaling in cancer; SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Neddylation; SCF(Skp2)-mediated degradation of p27/p21; Negative regulation of NOTCH4 signaling; Regulation of PLK1 Activity at G2/M Transition; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Cyclin D associated events in G1; Regulation of BACH1 activity; MAP3K8 (TPL2)-dependent MAPK1/3 activation; NOTCH1 Intracellular Domain Regulates Transcription; Prolactin receptor signaling; Iron uptake and transport; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling","Cell cycle; TNF-alpha signaling pathway; TGF-beta signaling pathway; Breast cancer pathway; Small cell lung cancer; Notch signaling pathway (Netpath)",4308.8,6405.6,3701.1,5491.8,6301.1,4832,0.8671029600178045,-0.20572478530655552,0.46953148743589396,0.32833527802806933,0.6277310484120996,0.20222639003565357,5467]
["P63279","SUMO-conjugating enzyme ubc9 [OS=Homo sapiens]",25,2,5,2,158,18,8.66,15.5,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","UBE2I","ENSG00000103275","Nucleocytoplasmic transport; NF-kappa B signaling pathway; Ubiquitin mediated proteolysis; MicroRNAs in cancer","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; Formation of Incision Complex in GG-NER; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; SUMOylation of intracellular receptors; Vitamin D (calciferol) metabolism; SUMOylation of transcription factors; Postmitotic nuclear pore complex (NPC) reformation; Negative regulation of activity of TFAP2 (AP-2) family transcription factors; Maturation of nucleoprotein; SUMOylation of immune response proteins; Maturation of nucleoprotein; SUMO is transferred from E1 to E2 (UBE2I, UBC9)","Androgen receptor signaling pathway; TGF-beta signaling pathway",691.6,973.1,586.2,740,735.9,271.4,1.288216104847479,0.36537463323476294,0.43505099984276235,0.3614598289028147,0.605097575233254,0.2181745873831028,5255]
["P67936","Tropomyosin alpha-4 chain [OS=Homo sapiens]",59,19,105,8,248,28.5,4.69,249.85,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","cytoskeletal activity;other molecular function","TPM4","ENSG00000167460","Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Hypertrophic cardiomyopathy; Dilated cardiomyopathy","Smooth Muscle Contraction; Striated Muscle Contraction; RHOV GTPase cycle; Signaling by ALK fusions and activated point mutants","Striated muscle contraction pathway",4903.6,7208.6,5267.7,5573.3,7100.9,6903,0.8877622949144923,-0.17175465914059476,0.4430276766865551,0.353569141820292,0.6117682389763899,0.21341307392758685,5293]
["P68133","Actin, alpha skeletal muscle [OS=Homo sapiens]",40,18,1223,3,377,42,5.39,3506.87,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ACTA1","ENSG00000143632","","Striated Muscle Contraction","Myometrial relaxation and contraction pathways; Fas ligand pathway and stress induction of heat shock proteins; Physico-chemical features and toxicity-associated pathways; Striated muscle contraction pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; IL-18 signaling pathway; Malignant pleural mesothelioma",42329.7,42303,43490.8,36132.3,36751.4,30290.6,1.2418160336440371,0.3124514642125102,0.01654640798325167,1.7812962715177412,0.1337806371123744,0.8736067401091315,904]
["P69905","Hemoglobin subunit alpha [OS=Homo sapiens]",22,3,75,3,142,15.2,8.68,198.38,"other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;cytosol;translational apparatus;other cell component","other molecular function","HBA1; HBA2","ENSG00000188536; ENSG00000206172","African trypanosomiasis; Malaria","Heme signaling; Scavenging of heme from plasma; Cytoprotection by HMOX1; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Effects of nitric oxide",9497,9538,9102.5,7865.2,8607.6,9512.5,1.08282375035116,0.11479843667923893,0.22170932305727006,0.6542160440655083,0.46753417259826513,0.3301866405594335,3466]
["P78345","Ribonuclease P protein subunit p38 [OS=Homo sapiens]",18,4,6,4,283,31.8,9.92,14.17,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RPP38","ENSG00000152464","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus","Integrated breast cancer pathway; Sphingolipid metabolism in senescence",302.6,356.3,317.6,354.4,394.1,646.7,0.6998996559633028,-0.5147799960027721,0.2075237638995246,0.6829321643037018,0.4529086862769857,0.3439893499595958,3349]
["P78356","Phosphatidylinositol 5-phosphate 4-kinase type-2 beta [OS=Homo sapiens]",31,11,34,6,416,47.3,7.33,83,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle","kinase activity;other molecular function","PIP4K2B","ENSG00000276293; ENSG00000277292","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Regulation of actin cytoskeleton","Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs in the nucleus","Regulation of actin cytoskeleton",1390.2,1335.2,1438.9,1416.7,1369,1797.6,0.9085811533174789,-0.13831271497962008,0.3714949522595855,0.43004708290125643,0.5629808430572901,0.24950638293916616,4823]
["P78410-1","Butyrophilin subfamily 3 member A2 [OS=Homo sapiens]",25,6,11,4,334,36.4,5.33,34.54,"signal transduction;other biological processes","plasma membrane;other membranes","signal transduction activity or receptor binding","BTN3A2","ENSG00000186470","","Butyrophilin (BTN) family interactions","",1064.4,1004.7,1066.7,1023.1,1030.7,2349.8,0.7120991915705331,-0.4898498800725251,0.392615933925173,0.40603207897097227,0.5748457253724139,0.2404486937613668,4992]
["P80297","metallothionein-1X [OS=Homo sapiens]",20,1,1,1,61,6.1,7.96,2.54,"stress response;other biological processes","nucleus;other cell component","other molecular function","MT1X","ENSG00000187193","Mineral absorption","Metallothioneins bind metals","Copper homeostasis; Zinc homeostasis; Oxidative stress response",43.4,53.8,43.9,37.4,43.8,45.9,1.11014948859166,0.1507539575923052,0.3331316893045765,0.4773840528821928,0.5470365124976746,0.2619836852807424,4451]
["P80303","Nucleobindin-2 [OS=Homo sapiens]",8,3,4,3,420,50.2,5.12,11.01,"","","","","","","","",312.7,762.2,357.5,549.9,675.7,1040.7,0.6320434187883334,-0.6619044258536506,0.24696144279602053,0.6073708462870565,0.4897018951156034,0.3100682152861385,3686]
["P82673-1","28S ribosomal protein S35, mitochondrial [OS=Homo sapiens]",30,9,16,8,323,36.8,8.24,39.55,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPS35","ENSG00000061794","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1760.7,2284.7,1721.4,2088.7,2153.6,1718,0.9675351911816519,-0.047613958984386355,0.7901068352721368,0.10231418107393722,0.8592308970397333,0.06589011459074354,6721]
["P82912-1","28S ribosomal protein S11, mitochondrial [OS=Homo sapiens]",34,4,10,4,194,20.6,10.81,31.36,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes","other membranes;cytosol;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPS11","ENSG00000181991","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",932.2,1057.4,992.7,924.6,883.1,973.7,1.0722298123247287,0.100614153527048,0.20793075941498868,0.6820812602785918,0.45325556831618025,0.34365685182343886,3353]
["P82987-1","ADAMTS-like protein 3 [OS=Homo sapiens]",1,1,1,1,1691,188.6,7.83,0,"cell organization and biogenesis;protein metabolism","non-structural extracellular;extracellular matrix;other cell component","other molecular function","ADAMTSL3","ENSG00000156218","","Defective B3GALTL causes PpS; O-glycosylation of TSR domain-containing proteins","",27.9,31.9,31.8,24.2,24.2,2.5,1.799607072691552,0.8476819420212486,0.13875275868889095,0.8577583734560799,0.3771453749561562,0.4234912137954085,2689]
["P84077","ADP-ribosylation factor 1 [OS=Homo sapiens]",73,11,196,5,181,20.7,6.8,662.51,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","ARF1","ENSG00000143761","Phospholipase D signaling pathway; Endocytosis; Vibrio cholerae infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Legionellosis","COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; COPI-mediated anterograde transport; Synthesis of PIPs at the plasma membrane; Intra-Golgi traffic; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis; trans-Golgi Network Vesicle Budding; Synthesis of PIPs at the Golgi membrane; Nef Mediated CD4 Down-regulation","Cell migration and invasion through p75NTR; Neural crest cell migration during development; Neural crest cell migration in cancer; Insulin signaling",16971.7,16676.1,15857.2,14093.5,15437.3,15953.2,1.0884047137454929,0.12221510984660969,0.1069604662398827,0.9707767126555056,0.3356694065037796,0.4740882393062134,2329]
["P84095","Rho-related GTP-binding protein RhoG [OS=Homo sapiens]",60,8,48,7,191,21.3,8.12,179.23,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","RHOG","ENSG00000177105","Bacterial invasion of epithelial cells; Salmonella infection; Yersinia infection","Neutrophil degranulation; RHOG GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; RHO GTPases activate KTN1","Brain-derived neurotrophic factor (BDNF) signaling pathway",3503.3,3385,3552.6,2939.9,2946.6,2889.9,1.1896563511234675,0.2505448910713222,4.6541020217704635E-4,3.3321641008502527,0.0251976530941632,1.5986399074612858,135]
["P98155-1","very low-density lipoprotein receptor [OS=Homo sapiens]",1,1,1,1,873,96,4.79,1.97,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","VLDLR","ENSG00000147852","Spinocerebellar ataxia; Lipid and atherosclerosis","VLDLR internalisation and degradation; Reelin signalling pathway; VLDL clearance","Familial hyperlipidemia type 3",23.3,14.1,23.9,30.1,24,29.4,0.7341317365269462,-0.4458891236706329,0.11691221563639238,{"$f":"-LOG10(AA2499)","v":0.9321401089723685},0.3486378556044031,{"$f":"-LOG10(AC2499)","v":0.4576254583404735},2451]
["P99999","cytochrome c [OS=Homo sapiens]",41,4,26,4,105,11.7,9.57,56.92,"other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus","other molecular function","CYCS","ENSG00000172115","Oxidative phosphorylation; Metabolic pathways; Platinum drug resistance; p53 signaling pathway; Apoptosis; Apoptosis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Legionellosis; Toxoplasmosis; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Colorectal cancer; Small cell lung cancer; Viral myocarditis; Lipid and atherosclerosis","Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Respiratory electron transport; TP53 Regulates Metabolic Genes; Detoxification of Reactive Oxygen Species; Formation of apoptosome; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity; Release of apoptotic factors from the mitochondria; Pyroptosis","miRNA regulation of DNA damage response; Alzheimer's disease and miRNA effects; AGE/RAGE pathway; Parkinson's disease pathway; Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; VEGFA-VEGFR2 signaling pathway; Oxidative damage response; NO/cGMP/PKG mediated neuroprotection; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Acute viral myocarditis; Nonalcoholic fatty liver disease; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Malignant pleural mesothelioma; Complement system in neuronal development and plasticity; Alzheimer's disease; DNA damage response",2574.6,2669.1,2668.4,2887.8,2643.8,1661.9,1.099895739209008,0.13736677497265884,0.5586831379190342,0.25283443624539875,0.6914011268286863,0.16026991699048543,5906]
["Q00013-1","55 kDa erythrocyte membrane protein [OS=Homo sapiens]",25,11,13,11,466,52.3,7.37,29.49,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","kinase activity","MPP1","ENSG00000130830; ENSGGOG00000001049; ENSPPAG00000040588; ENSPTRG00000022450; ENSPTRG00000051407","","Sensory processing of sound by outer hair cells of the cochlea","MECP2 and associated Rett syndrome",1323,1298.7,1392.9,1307,1263,1872.7,0.9036396785738403,-0.14618047441654156,0.5116267508037311,0.2910467561739923,0.6574331789072557,0.1821483820117292,5688]
["Q00577","Transcriptional activator protein Pur-alpha [OS=Homo sapiens]",43,9,24,9,322,34.9,6.44,87.56,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","PURA","ENSG00000185129","","","Exercise-induced circadian regulation",3303.8,3210.7,2939,3082,3126.9,1980.6,1.1543439770437753,0.2070731893471737,0.34131307918366743,0.46684706915335744,0.5496050442285582,0.2599492900122336,4539]
["Q00653-1","Nuclear factor NF-kappa-B p100 subunit [OS=Homo sapiens]",34,22,60,21,900,96.7,6.25,196.7,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NFKB2","ENSG00000077150","MAPK signaling pathway; NF-kappa B signaling pathway; Osteoclast differentiation; C-type lectin receptor signaling pathway; Legionellosis; Human T-cell leukemia virus 1 infection; Epstein-Barr virus infection; Pathways in cancer; Viral carcinogenesis; Breast cancer","Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; PKMTs methylate histone lysines; RIP-mediated NFkB activation via ZBP1; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; Interleukin-1 processing; DEx/H-box helicases activate type I IFN and inflammatory cytokines production ; SUMOylation of immune response proteins","Regulation of toll-like receptor signaling pathway; Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Neural crest differentiation; Thymic stromal lymphopoietin (TSLP) signaling pathway; TNF-alpha signaling pathway; Ebstein-Barr virus LMP1 signaling; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Toll-like receptor signaling related to MyD88; ApoE and miR-146 in inflammation and atherosclerosis; Ebola virus pathway in host; Breast cancer pathway; Acute viral myocarditis; miRNAs involvement in the immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Interactions between immune cells and microRNAs in tumor microenvironment; Head and neck squamous cell carcinoma; IL-18 signaling pathway; FGF23 signaling in hypophosphatemic rickets and related disorders; Mitochondrial immune response to SARS-CoV-2; Neuroinflammation and glutamatergic signaling; Network map of SARS-CoV-2 signaling pathway; Inclusion body myositis; Sudden infant death syndrome (SIDS) susceptibility pathways",6609.4,6771.5,6501.3,8031,7792.6,7409.6,0.855766747585352,-0.22471047344610542,4.797842211441858E-3,2.318954038949874,0.07673397970115654,1.1150122771357514,457]
["Q00987-1","E3 ubiquitin-protein ligase Mdm2 [OS=Homo sapiens]",14,6,9,6,491,55.2,4.69,20.89,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","MDM2","ENSG00000135679","Endocrine resistance; Platinum drug resistance; FoxO signaling pathway; Cell cycle; p53 signaling pathway; Ubiquitin mediated proteolysis; Endocytosis; PI3K-Akt signaling pathway; Cellular senescence; C-type lectin receptor signaling pathway; Thyroid hormone signaling pathway; Shigellosis; Human cytomegalovirus infection; Human papillomavirus infection; Epstein-Barr virus infection; Pathways in cancer; Transcriptional misregulation in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Glioma; Prostate cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia","Ub-specific processing proteases; Oxidative Stress Induced Senescence; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of RUNX3 expression and activity; SUMOylation of ubiquitinylation proteins; SUMOylation of transcription factors; Regulation of TP53 Degradation; Regulation of TP53 Activity through Phosphorylation; Oncogene Induced Senescence; Regulation of TP53 Activity through Methylation; AKT phosphorylates targets in the cytosol; Stabilization of p53; Trafficking of AMPA receptors","Androgen receptor signaling pathway; miRNA regulation of DNA damage response; TP53 network; Cell cycle; Glioblastoma signaling pathways; Retinoblastoma gene in cancer; Apoptosis; Bladder cancer; Copper homeostasis; VEGFA-VEGFR2 signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of p53 pathway in prostate cancer; PI3K-Akt signaling pathway; Genotoxicity pathway; G1 to S cell cycle control; Male infertility; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; Malignant pleural mesothelioma; Senescence and autophagy in cancer; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)",644.5,659,661.5,530,545.9,1817.5,0.6791318172392341,-0.558236470902971,0.5083333327183772,0.2938514115622454,0.6550437815300809,0.18372967185328262,5672]
["Q01167","Forkhead box protein K2 [OS=Homo sapiens]",8,5,12,4,660,69,9.54,25.47,"other metabolic processes;stress response;other biological processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","FOXK2","ENSG00000141568","","UCH proteinases","",507.9,505.3,544.1,582.5,557,677.6,0.857024929833251,-0.2225909236608006,0.0892663401497137,1.0493122705959903,0.3067455007777421,0.5132217986147464,2127]
["Q01518-1","adenylyl cyclase-associated protein 1 [OS=Homo sapiens]",53,23,275,1,475,51.9,8.06,908.04,"cell organization and biogenesis;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","CAP1","ENSG00000131236","","Neutrophil degranulation; Platelet degranulation ; Role of ABL in ROBO-SLIT signaling","Angiopoietin-like protein 8 regulatory pathway; Insulin signaling; Complement system in neuronal development and plasticity",567.5,586,578.9,597.1,577.2,848.1,0.8566060126582279,-0.22329629110953453,0.33046060685774487,0.48088030393620423,0.5452227032783876,0.26342606827530085,4430]
["Q01581","hydroxymethylglutaryl-CoA synthase, cytoplasmic [OS=Homo sapiens]",20,9,22,9,520,57.3,5.41,67.63,"other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","other molecular function","HMGCS1","ENSG00000112972","Valine, leucine and isoleucine degradation; Butanoate metabolism; Terpenoid backbone biosynthesis; Metabolic pathways; PPAR signaling pathway","PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Endochondral ossification; Endochondral ossification with skeletal dysplasias",2482.7,2536.5,2441.6,5696.1,5759.4,3125.9,0.511665546518167,-0.9667270034992281,0.05218601006601598,1.2824459062974896,0.23458028755996976,0.6297084856715659,1626]
["Q01974","Tyrosine-protein kinase transmembrane receptor ROR2 [OS=Homo sapiens]",3,3,3,3,943,104.7,6.55,6.43,"cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","ROR2","ENSG00000169071","Wnt signaling pathway","WNT5A-dependent internalization of FZD2, FZD5 and ROR2","Cardiac progenitor differentiation; Ectoderm differentiation; Wnt signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Malignant pleural mesothelioma",345.9,339.4,427.4,382,433.9,580.4,0.7968917854329297,-0.32754426931533875,0.22419900957505406,0.6493663102826998,0.4707470729629618,0.3272123716830152,3481]
["Q02040-1","A-kinase anchor protein 17A [OS=Homo sapiens]",16,12,23,12,695,80.7,9.73,49.25,"RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus","other molecular function","AKAP17A","ENSG00000197976","","","",2561.9,2445.5,2577,2736.8,2832,2643.9,0.923496535853008,-0.11482154539276186,0.037542517912954106,1.4254766033441093,0.201911893617205,0.6948380981926306,1359]
["Q02241-1","Kinesin-like protein KIF23 [OS=Homo sapiens]",27,19,31,19,960,110,8.51,90.01,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KIF23","ENSG00000137807","MicroRNAs in cancer","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; MHC class II antigen presentation; Mitotic Telophase/Cytokinesis","Malignant pleural mesothelioma",2355.8,2343.9,2380.4,1867.2,1940.4,1736.3,1.277097350240805,0.35286850261035896,0.001078504991256935,2.967177840667761,0.0404245793902407,1.393354490146306,195]
["Q02383","Semenogelin-2 [OS=Homo sapiens]",1,1,2,1,582,65.4,9.07,4.54,"stress response;other biological processes","non-structural extracellular","other molecular function","SEMG2","ENSG00000124157","","","Genotoxicity pathway",384.9,366.2,380,377.9,362.2,513.4,0.9023534104507379,-0.148235513239784,0.44603173527107676,0.3506342400260057,0.612675428133114,0.21276953706675517,5321]
["Q02556","Interferon regulatory factor 8 [OS=Homo sapiens]",2,1,2,1,426,48.3,6.77,2.2,"other metabolic processes;stress response;transport;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","IRF8","ENSG00000140968","Pertussis","Interferon gamma signaling; Interferon alpha/beta signaling","Vitamin D receptor pathway; Development of pulmonary dendritic cells and macrophage subsets; Type II interferon signaling (IFNG)",25.2,67.4,68.6,80.7,51.5,4163.5,0.037525897991014266,-4.73596959396655,0.37006281862072776,0.4317245476501568,0.5620925065043432,0.25019220443399093,4812]
["Q03001-7","dystonin [OS=Homo sapiens]",12,83,135,79,7570,860.1,5.25,375.37,"cell adhesion;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","DST","ENSG00000151914","","RND1 GTPase cycle; RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; Type I hemidesmosome assembly","",11406,11294,11865.6,13901.4,13249.9,12874.6,0.863580831411661,-0.21159687414650516,0.006332023548715378,2.198457478671001,0.08618391083344636,1.0645738024865834,537]
["Q03252","Lamin-B2 [OS=Homo sapiens]",64,48,309,41,620,69.9,5.59,891.24,"","other membranes;cytoskeleton;nucleus","other molecular function","LMNB2","ENSG00000176619","Apoptosis","","Gastric cancer network 2; Fas ligand pathway and stress induction of heat shock proteins; IL-18 signaling pathway; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome",34278.9,33846.4,34777.8,37355.7,34099.4,36810.3,0.9504707875276865,-0.07328580818879551,0.1614992573647787,0.7918294703800624,0.40163255259583786,0.3961710945687019,2939]
["Q03468","DNA excision repair protein ERCC-6 [OS=Homo sapiens]",3,4,4,4,1493,168.3,8.09,11.65,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","ERCC6","ENSG00000225830","Nucleotide excision repair","Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; B-WICH complex positively regulates rRNA expression; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression","Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum",381.3,375.7,381,445.7,415.7,379,0.9174459851660753,-0.12430487341867832,0.15286967356406472,0.8156786618087051,0.39190615365827747,0.40681791723419214,2851]
["Q04656-1","copper-transporting ATPase 1 [OS=Homo sapiens]",8,8,15,8,1500,163.3,6.24,40.93,"","","","","","","","",1074.1,1112.7,1199.6,1178.6,1128.2,1399.4,0.9137121580055042,-0.13018834275614635,0.30725424368035154,0.5125021100876203,0.5310289115771316,0.2748818333505476,4229]
["Q04695","Keratin, type I cytoskeletal 17 [OS=Homo sapiens]",27,12,31,3,432,48.1,5.02,86.77,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","other molecular function","KRT17","ENSG00000128422","Estrogen signaling pathway; Staphylococcus aureus infection","Formation of the cornified envelope","",327.5,222.5,383.4,287.3,360.6,1769.8,0.3860694048062208,-1.3730678666456049,0.365089329882214,0.4376008595755846,0.5605962000229205,0.25134985041210484,4760]
["Q05469-1","hormone-sensitive lipase [OS=Homo sapiens]",9,7,14,7,1076,116.5,6.7,42.9,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","LIPE","ENSG00000079435","cAMP signaling pathway; AMPK signaling pathway; Apelin signaling pathway; Thermogenesis; Insulin signaling pathway; Regulation of lipolysis in adipocytes; Aldosterone synthesis and secretion","Triglyceride catabolism","AMP-activated protein kinase (AMPK) signaling; Fatty acid beta-oxidation; Adipogenesis; Triacylglyceride synthesis; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Lipid metabolism pathway; Thermogenesis; Insulin signaling; Orexin receptor pathway; Familial partial lipodystrophy (FPLD)",682.6,698.7,735.2,682.7,678.1,921.7,0.9272727272727272,-0.10893437155316406,0.5364937279942313,0.2704353508898622,0.6753759314346945,0.1704544205015442,5806]
["Q05519","serine/arginine-rich splicing factor 11 [OS=Homo sapiens]",18,10,38,10,484,53.5,10.52,76.07,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","SRSF11","ENSG00000116754","","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript","",4535.4,4429.3,4411.7,4569.3,4557.2,3760.7,1.0379601465019554,0.05375105106786217,0.5788798787863769,0.23741154575866671,0.7055249348090094,0.15148763271247312,5997]
["Q06124-2","Isoform 2 of Tyrosine-protein phosphatase non-receptor type 11 [OS=Homo sapiens]",39,21,47,21,593,68,7.3,127.47,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","PTPN11","ENSG00000179295; ENSMMUG00000013253; ENSRROG00000031729","Ras signaling pathway; Phospholipase D signaling pathway; Axon guidance; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; Leukocyte transendothelial migration; Neurotrophin signaling pathway; Adipocytokine signaling pathway; Insulin resistance; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Herpes simplex virus 1 infection; Proteoglycans in cancer; Chemical carcinogenesis; Renal cell carcinoma; Chronic myeloid leukemia; PD-L1 expression and PD-1 checkpoint pathway in cancer","PIP3 activates AKT signaling; GPVI-mediated activation cascade; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by SCF-KIT; RET signaling; Platelet sensitization by LDL; CTLA4 inhibitory signaling; FLT3 Signaling; Interleukin-3, Interleukin-5 and GM-CSF signaling; PD-1 signaling; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; Signal regulatory protein family interactions; PI3K Cascade; Downstream signal transduction; Tie2 Signaling; Interleukin-6 signaling; Signaling by Leptin; Regulation of IFNG signaling; Regulation of IFNA signaling; Signaling by CSF3 (G-CSF); GAB1 signalosome; PI-3K cascade:FGFR1; FRS-mediated FGFR1 signaling; PI-3K cascade:FGFR2; FRS-mediated FGFR2 signaling; FRS-mediated FGFR3 signaling; PI-3K cascade:FGFR3; FRS-mediated FGFR4 signaling; PI-3K cascade:FGFR4; Activated NTRK2 signals through FRS2 and FRS3; Spry regulation of FGF signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; Prolactin receptor signaling; Interleukin-20 family signaling; Netrin mediated repulsion signals; Interleukin-37 signaling; Signaling by FLT3 ITD and TKD mutants; PECAM1 interactions; MET activates PTPN11; STAT5 activation downstream of FLT3 ITD mutants; Regulation of RUNX1 Expression and Activity; STAT5 Activation","IL-5 signaling pathway; Heart development; IL-1 signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Pilocytic astrocytoma; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL-6 signaling pathway; Hepatitis C and hepatocellular carcinoma; VEGFA-VEGFR2 signaling pathway; Embryonic stem cell pluripotency pathways; IL-4 signaling pathway; Ras signaling; EGF/EGFR signaling pathway; Fragile X syndrome; Cancer immunotherapy by CTLA4 blockade; Cancer immunotherapy by PD-1 blockade; Gastrin signaling pathway; Netrin-UNC5B signaling pathway; Insulin signaling; IL-2 signaling pathway; Angiotensin II receptor type 1 pathway; Kallmann syndrome; Interferon type I signaling pathways; Type II interferon signaling (IFNG); T-cell receptor (TCR) signaling pathway",6045.5,5907.3,6011,5829.4,5349.3,5228,{"$f":"AVERAGE(S2626:U2626)/AVERAGE(V2626:X2626)","v":1.0949063492353732},{"$f":"LOG(Y2626,2)","v":0.13080747688425096},{"$f":"TTEST(V2626:X2626,S2626:U2626,2,2)","v":0.05100422306791022},1.2923938635263852,{"$f":"AA2626*7309/AE2626","v":0.2319787594295929},0.6345517784057567,1607]
["Q06481","Amyloid-like protein 2 [OS=Homo sapiens]",4,4,4,4,763,86.9,4.79,8.09,"signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","APLP2","ENSG00000084234","","Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","Splicing factor NOVA regulated synaptic proteins",532.4,490.2,536.2,455,450.7,610.3,1.0282321899736149,0.04016608311058336,0.8065206816884352,0.09338449147650706,0.8690637862982121,0.06094834665755623,6783]
["Q07020","60S ribosomal protein L18 [OS=Homo sapiens]",46,8,48,8,188,21.6,11.72,150.29,"protein metabolism;other metabolic processes","cytosol;ER/Golgi;translational apparatus;nucleus","nucleic acid binding activity;other molecular function","RPL18","ENSG00000063177","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis","Cytoplasmic ribosomal proteins",6470.3,6358.8,5876,6706,7625.6,6459.6,0.8996642810419792,-0.15254134948156683,0.15627690210599773,0.8061052064286046,0.39564526411248263,0.4026940284253522,2887]
["Q07157","Tight junction protein ZO-1 [OS=Homo sapiens]",18,28,46,26,1748,195.3,6.7,137.15,"cell adhesion;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","TJP1","ENSG00000104067; ENSG00000277401","Adherens junction; Tight junction; Gap junction; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection","RUNX1 regulates expression of components of tight junctions; Signaling by Hippo; Apoptotic cleavage of cell adhesion  proteins; Regulation of gap junction activity","Epithelial to mesenchymal transition in colorectal cancer; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; Disruption of postsynaptic signaling by CNV; 1q21.1 copy number variation syndrome",4082,4051.5,4125.1,5215.9,4976.2,7524.5,0.6919273449758984,-0.5313075375831301,0.08876116494673364,1.051777006500664,0.3060166766960737,0.5142549055454423,2120]
["Q07866-6","Isoform N of Kinesin light chain 1 [OS=Homo sapiens]",38,25,77,21,628,71,6.67,227.5,"","","","KLC1","","","","",9262.8,9319.2,9053.7,9975.5,10145.3,6531.6,1.0368934880160885,0.05226770494855189,0.7949650366763199,0.09965197161076257,0.8618213368536373,0.0645827579117427,6742]
["Q07889","Son of sevenless homolog 1 [OS=Homo sapiens]",7,8,10,8,1333,152.4,6.84,23.92,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","SOS1","ENSG00000115904","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Chemokine signaling pathway; FoxO signaling pathway; Phospholipase D signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Focal adhesion; Gap junction; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Thermogenesis; Neurotrophin signaling pathway; Regulation of actin cytoskeleton; Insulin signaling pathway; GnRH signaling pathway; Estrogen signaling pathway; Prolactin signaling pathway; Relaxin signaling pathway; Growth hormone synthesis, secretion and action; Alcoholism; Hepatitis C; Hepatitis B; Human cytomegalovirus infection; Human papillomavirus infection; Pathways in cancer; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Endometrial cancer; Glioma; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Choline metabolism in cancer","RAC1 GTPase cycle; Role of LAT2/NTAL/LAB on calcium mobilization; RET signaling; FLT3 Signaling; Downstream signal transduction; Tie2 Signaling; FRS-mediated FGFR1 signaling; FRS-mediated FGFR2 signaling; FRS-mediated FGFR3 signaling; FRS-mediated FGFR4 signaling; Activated NTRK2 signals through FRS2 and FRS3; Signaling by FLT3 ITD and TKD mutants; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; NRAGE signals death through JNK; G alpha (12/13) signalling events; Interleukin receptor SHC signaling; RAF/MAP kinase cascade; DAP12 signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; Regulation of KIT signaling; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; GRB2 events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; GRB2 events in EGFR signaling; SHC1 events in EGFR signaling; NCAM signaling for neurite out-growth; Signaling by FGFR1 in disease; SHC-mediated cascade:FGFR1; SHC-mediated cascade:FGFR2; Signaling by FGFR2 in disease; SHC-mediated cascade:FGFR3; SHC-mediated cascade:FGFR4; Signaling by FGFR3 point mutants in cancer; Activation of RAC1; Erythropoietin activates RAS; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; SOS-mediated signalling; Signalling to RAS; SHC-related events triggered by IGF1R; Signaling by FGFR4 in disease; MET activates RAS signaling; Signaling by FGFR3 fusions in cancer; Activated NTRK2 signals through RAS; Activated NTRK3 signals through RAS; Constitutive Signaling by Overexpressed ERBB2; Signaling by FLT3 fusion proteins; Signal attenuation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Interleukin-15 signaling","IL-5 signaling pathway; Integrin-mediated cell adhesion; Leptin signaling pathway; Prolactin signaling pathway; Pilocytic astrocytoma; B cell receptor signaling pathway; TNF-alpha signaling pathway; Oncostatin M signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL-6 signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Acute viral myocarditis; Thermogenesis; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Malignant pleural mesothelioma; Regulation of actin cytoskeleton; EPO receptor signaling; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent)",764.6,763.4,822.7,809.9,795.5,843.6,0.9598611678236013,-0.05910234215423245,0.24734451214825096,0.6066977209180399,0.4900626292468328,0.30974841426087035,3689]
["Q08378","Golgin subfamily A member 3 [OS=Homo sapiens]",27,31,49,31,1498,167.3,5.44,179.93,"other biological processes","other membranes;cytosol;ER/Golgi;nucleus","","GOLGA3","ENSG00000090615","","RND2 GTPase cycle","",3925.9,3898.8,3804,4138.6,4304.2,5305.8,0.8458097551750726,-0.24159489505323226,0.12608297326426732,0.8993435582853642,0.36096374915336066,0.4425364112056416,2553]
["Q08752","peptidyl-prolyl cis-trans isomerase D [OS=Homo sapiens]",59,23,87,22,370,40.7,7.21,264.19,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","PPID","ENSG00000171497","Necroptosis; Cellular senescence; Alzheimer disease; Pathways of neurodegeneration; Shigellosis","ESR-mediated signaling","Alzheimer's disease and miRNA effects; NO/cGMP/PKG mediated neuroprotection; Alzheimer's disease",11513.2,11348,11704.5,12414,12837.2,11379.6,0.9436239448769886,-0.08371606681763501,0.1968055812637335,0.7059625894530971,0.44396666464710743,0.35264963777573627,3240]
["Q08AD1","Calmodulin-regulated spectrin-associated protein 2 [OS=Homo sapiens]",8,9,11,9,1489,168,6.8,30.42,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi","cytoskeletal activity;other molecular function","CAMSAP2","ENSG00000118200","","","",826.8,872.9,892.2,1041.6,1035.4,2342.4,0.5864823279178168,-0.7698404577494222,0.23405676103304135,0.6306788091960892,0.47986560067054673,0.31888038150000064,3565]
["Q09327","Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase [OS=Homo sapiens]",8,3,3,3,533,61.3,8.28,8.11,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi","other molecular function","MGAT3","ENSG00000128268","N-Glycan biosynthesis; Metabolic pathways","Reactions specific to the hybrid N-glycan synthesis pathway","",145.1,148.5,144.4,235.5,286.9,183.4,0.6205724001133466,-0.6883285602911884,0.04053728848772527,1.39214530434064,0.20953821892276098,0.6787367519175477,1414]
["Q0P6H9","Transmembrane protein 62 [OS=Homo sapiens]",11,5,7,5,643,73.1,9.26,26.35,"","other membranes","other molecular function","TMEM62","ENSG00000137842","","","",439.9,439.1,479.8,481.6,412.6,618.7,{"$f":"AVERAGE(S2690:U2690)/AVERAGE(V2690:X2690)","v":0.8981426399629849},{"$f":"LOG(Y2690,2)","v":-0.154983507799279},{"$f":"TTEST(V2690:X2690,S2690:U2690,2,2)","v":0.4542392272176782},0.3427153636685693,{"$f":"AA2690*7309/AE2690","v":0.6171067865676598},0.2096396774509855,5380]
["Q0VDG4-1","secernin-3 [OS=Homo sapiens]",26,9,16,9,424,48.5,5.55,46.04,"protein metabolism","","other molecular function","SCRN3","ENSG00000144306","","","",1529,1460.3,1504.5,1498.9,1465.6,1103.5,1.1046705998033433,0.14361623850689617,0.33033845111624227,0.4810408718560023,0.5451442174776733,0.263488590256788,4429]
["Q11201","CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 [OS=Homo sapiens]",15,4,7,4,340,39.1,9.09,28.5,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","ST3GAL1","ENSG00000008513","Mucin type O-glycan biosynthesis; Glycosaminoglycan biosynthesis; Glycosphingolipid biosynthesis; Glycosphingolipid biosynthesis; Metabolic pathways","Maturation of spike protein; Sialic acid metabolism; Keratan sulfate biosynthesis; Maturation of protein 3a; Maturation of protein 3a; Termination of O-glycan biosynthesis","Ganglio sphingolipid metabolism; Globo sphingolipid metabolism",555.6,534.4,585,760,842.4,894.8,0.6707512413903572,-0.5761502753366313,2.8200153844223034E-3,2.5497485224070613,0.059058717606712365,1.2287159874822684,349]
["Q12765","Secernin-1 [OS=Homo sapiens]",3,1,1,1,414,46.4,4.75,2.14,"protein metabolism;transport","other membranes;nucleus;other cell component","other molecular function","SCRN1","ENSG00000136193","","","",42.5,36.9,36.5,49.1,27.6,96.7,0.668396770472895,-0.5812233322153633,0.40290502125396305,0.3947973201288729,0.5824431962708102,0.23474642351922848,5056]
["Q12792-2","Twinfilin-1 [OS=Homo sapiens]",40,12,33,9,350,40.3,6.96,94.03,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","TWF1","ENSG00000151239","","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHOBTB2 GTPase cycle","",1980.2,2054,1982.9,2219.2,2014.8,2623.6,0.8774352543163789,-0.18863542157600863,0.1955793025892303,0.7086771068433757,0.4425662918342676,0.35402166729050566,3230]
["Q12824-1","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 [OS=Homo sapiens]",37,10,52,10,385,44.1,6.23,155.01,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","LOC101347788; LOC111142756; Smarcb1; SMARCB1","ENSCAFG00000014105; ENSCATG00000029590; ENSCCAG00000036123; ENSCHIG00000019816; ENSCSAG00000011285; ENSDLEG00000015913; ENSECAG00000007797; ENSG00000099956; ENSG00000275837; ENSHGLG00000019077; ENSMFAG00000040790; ENSMLUG00000004975; ENSMMUG00000009098; ENSMNEG00000033936; ENSMUSG00000000902; ENSPANG00000026464; ENSPPAG00000028391; ENSRBIG00000027964; ENSRFEG00010017090; ENSRROG00000030710; ENSSBOG00000031674; ENSSSCG00000010070; ENSSSCG00070020965; ENSSSUG00005014167; ENSSTOG00000012408; ENSTSYG00000008262; ENSUAMG00000010813","Thermogenesis; Hepatocellular carcinoma","RMTs methylate histone arginines; RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines","TNF-alpha NF-kB signaling pathway; Tumor suppressor activity of SMARCB1; Thermogenesis; Modulators of TCR signaling and T cell activation",2730.4,2632.9,2730.2,2911.4,2810.9,2680.2,0.9632252305861351,-0.054054912543938745,0.23840299795483413,0.6226882875767046,0.4828172657389534,0.31621720775223877,3609]
["Q12851","Mitogen-activated protein kinase kinase kinase kinase 2 [OS=Homo sapiens]",13,8,11,8,820,91.5,6.34,30,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi","kinase activity;other molecular function","MAP4K2","ENSG00000168067","MAPK signaling pathway","","TNF-alpha signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Insulin signaling; Malignant pleural mesothelioma",603,601.8,603.2,629.5,640.7,731.2,0.9033676426501448,-0.14661485548009834,0.1158345781241332,0.9361617787183867,0.34740867111583484,0.459159346019138,2437]
["Q12893","Transmembrane protein 115 [OS=Homo sapiens]",15,4,8,4,351,38.2,8.16,28.67,"transport;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","TMEM115","ENSG00000126062","","COPI-mediated anterograde transport","",379.4,387.5,394.1,405.9,346.6,449.4,0.9659705466344952,-0.04994889430680967,0.6740182554124364,0.17132834067904332,0.7693892595360765,0.11385388061923794,6403]
["Q12907","Vesicular integral-membrane protein VIP36 [OS=Homo sapiens]",42,13,93,13,356,40.2,6.95,303.48,"cell organization and biogenesis;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","LMAN2","ENSG00000169223","Protein processing in endoplasmic reticulum","COPII-mediated vesicle transport; Cargo concentration in the ER","",13449.6,13809.3,14278,12068.5,12275,12963.1,1.1133928044903583,0.1549626646594583,0.017524606978234478,1.75635171311012,0.13728547953259998,0.8623753949726471,933]
["Q12931","heat shock protein 75 kDa, mitochondrial [OS=Homo sapiens]",50,30,194,29,704,80.1,8.21,663.74,"other biological processes","other membranes;mitochondrion;nucleus","signal transduction activity or receptor binding;other molecular function","TRAP1","ENSG00000126602","Parkinson disease; Pathways of neurodegeneration","Respiratory electron transport","TNF-alpha signaling pathway; TGF-beta signaling pathway",17450.3,16850,17540.5,15818.5,15338.3,15506.9,1.110944910069283,0.15178727762672892,2.6113421039471426E-3,2.583136228857273,0.05663590337611177,1.2469081678446383,337]
["Q12979","active breakpoint cluster region-related protein [OS=Homo sapiens]",17,15,38,15,859,97.5,6.55,106.76,"signal transduction;other biological processes","cytosol;other cell component","enzyme regulator activity","ABR","ENSG00000159842; ENSG00000276016; ENSG00000278741","","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC3 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOC GTPase cycle; RAC2 GTPase cycle; RHOB GTPase cycle","",5044.8,5085.2,4934.7,4838.1,4608.3,3004.6,1.2099188820175084,0.27491032648001995,0.20649100539442902,0.6850988611632371,0.4520044200143401,0.344857318333635,3339]
["Q12982","BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 [OS=Homo sapiens]",13,5,6,5,314,36,4.81,16.43,"other metabolic processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","BNIP2","ENSG00000140299","","Myogenesis","Acute viral myocarditis",842,876.9,846.5,896.2,992.8,623.9,1.020892196267261,0.029830529171632814,0.8823520891459883,0.0543580816925503,0.9242062796744094,0.034231084920669355,6978]
["Q13033-2","Isoform Alpha of Striatin-3 [OS=Homo sapiens]",11,6,9,1,713,77.7,5.26,23.04,"","","","STRN3","","","","",30.8,24.8,35.6,29.7,41.2,39.5,0.8260869565217391,-0.27563444261342734,0.24948278665848983,0.6029594136362737,0.4920317559867518,0.30800686673517946,3706]
["Q13085-1","Acetyl-CoA carboxylase 1 [OS=Homo sapiens]",18,34,70,29,2346,265.4,6.37,209.21,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","ACACA","ENSG00000275176; ENSG00000278540","Fatty acid biosynthesis; Pyruvate metabolism; Propanoate metabolism; Metabolic pathways; Fatty acid metabolism; AMPK signaling pathway; Insulin signaling pathway; Glucagon signaling pathway; Alcoholic liver disease","Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency; ChREBP activates metabolic gene expression; Carnitine metabolism; Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis","AMP-activated protein kinase (AMPK) signaling; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; Corticotropin-releasing hormone signaling pathway; Mesodermal commitment pathway; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin and adiponectin; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Mitochondrial fatty acid synthesis pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; 7q11.23 copy number variation syndrome",6675.2,6778,6679.9,6580.9,6338.7,7368.5,0.992360053430336,-0.011064432891476277,0.8767657004284586,0.05711644837387179,0.920333262161655,0.03605488166547897,6963]
["Q13107-1","Ubiquitin carboxyl-terminal hydrolase 4 [OS=Homo sapiens]",25,18,30,17,963,108.5,5.71,84.23,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","USP4","ENSG00000114316","","Ub-specific processing proteases; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; TNFR1-induced proapoptotic signaling","",2471,2385.4,2479.2,2510.5,2349.7,2009,1.0678972806149187,0.09477288309808224,0.36097527228561893,0.4425225473401188,0.5590947796430576,0.2525145627990951,4719]
["Q13144","Translation initiation factor eIF-2B subunit epsilon [OS=Homo sapiens]",25,14,54,14,721,80.3,5.08,172.66,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;translational apparatus;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","EIF2B5","ENSG00000145191","Herpes simplex virus 1 infection","Recycling of eIF2:GDP","Translation factors; MicroRNAs in cardiomyocyte hypertrophy",4888.7,4880.9,4884,4725.6,4582.1,6262.7,0.941119046395725,-0.08755086738336676,0.6003079305722432,0.22162591921115424,0.718344902513511,0.1436669857115649,6108]
["Q13164-1","Mitogen-activated protein kinase 7 [OS=Homo sapiens]",8,4,10,4,816,88.3,5.88,27.2,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","MAPK7","ENSG00000166484","MAPK signaling pathway; Gap junction; IL-17 signaling pathway; Neurotrophin signaling pathway; GnRH signaling pathway; Oxytocin signaling pathway; MicroRNAs in cancer; Fluid shear stress and atherosclerosis","Senescence-Associated Secretory Phenotype (SASP); Gastrin-CREB signalling pathway via PKC and MAPK; ERKs are inactivated; RET signaling; Signalling to ERK5","MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Brain-derived neurotrophic factor (BDNF) signaling pathway; S1P receptor signal transduction; Cardiac hypertrophic response; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Osteoblast differentiation and related diseases; Insulin signaling; Malignant pleural mesothelioma",234.6,249.5,264.4,256.1,273.9,513.5,0.7172975563009104,-0.4793563791014183,0.3039051676407851,0.517261915060576,0.52823849471736,0.2771699533105339,4205]
["Q13188","serine/threonine-protein kinase 3 [OS=Homo sapiens]",22,10,38,6,491,56.3,5.24,113.73,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","STK3","ENSG00000104375","MAPK signaling pathway; Hippo signaling pathway; Hippo signaling pathway","Signaling by Hippo","MAPK signaling pathway; Transcription co-factors SKI and SKIL protein partners; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Overview of leukocyte-intrinsic Hippo pathway functions; Malignant pleural mesothelioma",1084.7,1057.4,1048.5,957.6,1044.5,679.1,1.1899895569148147,0.2509489128161457,0.19999391825416107,0.6989832108801078,0.4452499386291999,0.35139613172547496,3283]
["Q13232","Nucleoside diphosphate kinase 3 [OS=Homo sapiens]",37,6,24,6,169,19,7.84,62.61,"other metabolic processes;other biological processes","cytosol","kinase activity;other molecular function","NME3","ENSG00000103024","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors","Interconversion of nucleotide di- and triphosphates","Pyrimidine metabolism",3387.3,3250,3391.5,3073,3146.3,3209.7,1.0636122600487856,0.08897231206531064,0.03056453479167852,1.514782210014705,0.18147537351127402,0.7411823010620483,1231]
["Q13243-1","Serine/arginine-rich splicing factor 5 [OS=Homo sapiens]",30,9,51,8,272,31.2,11.59,160.37,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","SFRS5; SRSF5","ENSCANG00000030560; ENSCCAG00000029002; ENSCJAG00000014884; ENSCSAG00000013041; ENSG00000100650; ENSGGOG00000016462; ENSMFAG00000002393; ENSMMUG00000022407; ENSMNEG00000030872; ENSNLEG00000001615; ENSPPAG00000029921; ENSPPYG00000005945; ENSPTRG00000006488; ENSRBIG00000013003; ENSRROG00000043407; ENSSBOG00000030784","Spliceosome; Herpes simplex virus 1 infection","mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","mRNA processing; mRNA Processing",5923.6,5613.2,5844.6,5863.6,6091,6165.1,0.9592542922896073,-0.0600147795460532,0.1313017566469547,0.881729463575595,0.36755440035717807,0.43467837351456645,2611]
["Q13303-2","Isoform 2 of Voltage-gated potassium channel subunit beta-2 [OS=Homo sapiens]",48,13,60,13,353,39.3,8.62,152.58,"","","","KCNAB2","","","","",6434.6,6420.9,6544.3,5938.5,5925.7,5065.1,1.14593042831068,0.19651945790113642,0.04765396548805729,1.3219009540408908,0.2250018305892834,0.6478139485037916,1548]
["Q13325","Interferon-induced protein with tetratricopeptide repeats 5 [OS=Homo sapiens]",21,9,16,9,482,55.8,7.4,47.35,"stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity","IFIT5","ENSG00000152778","","Interferon alpha/beta signaling","",1477.4,1410.2,1417.5,1588.6,1413.3,981.1,1.0808686919407484,0.11219126961073161,0.5865028777271754,0.231729852639728,0.7099618306240353,0.14876499944283395,6038]
["Q13395","Probable methyltransferase TARBP1 [OS=Homo sapiens]",2,3,3,3,1621,181.6,7.05,7.9,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","TARBP1","ENSG00000059588","","","",290,272.6,315.1,285.2,281.5,464.3,0.851309408341416,-0.2322445202602482,0.4532581286953291,0.3436543985598211,0.6166909275193895,0.20993244067252595,5372]
["Q13423","NAD(P) transhydrogenase, mitochondrial [OS=Homo sapiens]",42,39,277,39,1086,113.8,8.09,854.59,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","NNT","ENSG00000112992","Nicotinate and nicotinamide metabolism; Metabolic pathways","Citric acid cycle (TCA cycle)","",40616.2,41092.2,42925.2,34477,35727.9,32138,1.2178040684795919,0.2842820378658739,0.004206645643632438,2.3760640702261044,0.07217458452889551,1.1416157074448505,426]
["Q13433-1","Zinc transporter ZIP6 [OS=Homo sapiens]",3,2,3,2,755,85,6.95,8.51,"transport;other biological processes","plasma membrane;other membranes;ER/Golgi","transporter activity","SLC39A6","ENSG00000141424","Alzheimer disease; Parkinson disease","Zinc influx into cells by the SLC39 gene family","Nuclear receptors meta-pathway; NRF2 pathway; Zinc homeostasis",468.1,467.3,512,508.5,501.1,549.7,0.9282370294362854,-0.10743484392254896,0.15234736929010667,0.8171650407038897,0.3911158841381769,0.4076945459668719,2847]
["Q13439-1","Golgin subfamily A member 4 [OS=Homo sapiens]",23,44,60,42,2230,261,5.39,181.85,"cell organization and biogenesis;transport;developmental processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","GOLGA4","ENSG00000144674","","Retrograde transport at the Trans-Golgi-Network; Signaling by membrane-tethered fusions of PDGFRA or PDGFRB","",4430.6,4347.8,4279,5062.7,4901,5392,0.850329193719596,-0.23390662516150054,0.007107401406695392,2.1482891560940987,0.08987542713068619,1.0463590326306547,578]
["Q13464","Rho-associated protein kinase 1 [OS=Homo sapiens]",36,47,75,41,1354,158.1,5.9,189.39,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function","ROCK1","ENSG00000067900","cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Vascular smooth muscle contraction; TGF-beta signaling pathway; Axon guidance; Focal adhesion; Tight junction; Platelet activation; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Pathogenic Escherichia coli infection; Shigellosis; Yersinia infection; Human cytomegalovirus infection; Pathways in cancer; Proteoglycans in cancer; MicroRNAs in cancer","Neutrophil degranulation; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHOB GTPase cycle; Sema4D induced cell migration and growth-cone collapse; RND3 GTPase cycle; RHOBTB1 GTPase cycle; EPHB-mediated forward signaling; Potential therapeutics for SARS; VEGFA-VEGFR2 Pathway; Apoptotic cleavage of cellular proteins; EPHA-mediated growth cone collapse; RHO GTPases Activate ROCKs; RHOH GTPase cycle","Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Microtubule cytoskeleton regulation; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Focal adhesion; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; EGF/EGFR signaling pathway; Gastrin signaling pathway; mBDNF and proBDNF regulation of GABA neurotransmission; MAP3K1 role in promoting and blocking gonadal determination; Airway smooth muscle cell contraction; RAS and bradykinin pathways in COVID-19; Regulation of actin cytoskeleton; G13 signaling pathway",8278.4,8273.7,7807.4,8906.5,8483,7989,0.9598479027523297,-0.05912228002172942,0.33161350133871625,0.4793677958614007,0.5454012334123935,0.26328388424625776,4444]
["Q13480-1","GRB2-associated-binding protein 1 [OS=Homo sapiens]",26,13,23,13,694,76.6,5.96,75.05,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;other cell component","","GAB1","ENSG00000109458","EGFR tyrosine kinase inhibitor resistance; ErbB signaling pathway; Ras signaling pathway; Phospholipase D signaling pathway; Neurotrophin signaling pathway; Bacterial invasion of epithelial cells; Proteoglycans in cancer; Renal cell carcinoma; Hepatocellular carcinoma; Gastric cancer","Signaling by ERBB2 KD Mutants; Signaling by FGFR1 in disease; Signaling by FGFR2 in disease; Signaling by FGFR3 point mutants in cancer; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FGFR4 in disease; Signaling by FGFR3 fusions in cancer; RET signaling; PIP3 activates AKT signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Constitutive Signaling by Aberrant PI3K in Cancer; MET activates RAP1 and RAC1; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); PI3K Cascade; PI3K events in ERBB2 signaling; GAB1 signalosome; PI-3K cascade:FGFR1; PI-3K cascade:FGFR2; PI-3K cascade:FGFR3; PI-3K cascade:FGFR4; MET activates PI3K/AKT signaling; MET activates PTPN11; MET receptor recycling; Activated NTRK2 signals through PI3K","Glioblastoma signaling pathways; B cell receptor signaling pathway; Alpha 6 beta 4 signaling pathway; Hepatocyte growth factor receptor signaling; IL-6 signaling pathway; BDNF-TrkB signaling; VEGFA-VEGFR2 signaling pathway; Embryonic stem cell pluripotency pathways; Ras signaling; EGF/EGFR signaling pathway; Fragile X syndrome; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; ErbB signaling pathway",1972.4,1996.5,1943.7,2221.9,2218,2830.7,0.8132203669573351,-0.2982817472153017,0.09089074892971671,1.0414803180237269,0.30927396830879866,0.5096566331672718,2148]
["Q13510","Acid ceramidase [OS=Homo sapiens]",39,14,67,14,395,44.6,7.62,179.54,"other metabolic processes;developmental processes;other biological processes","non-structural extracellular;nucleus;other cytoplasmic organelle;other cell component","other molecular function","ASAH1","ENSG00000104763","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway; Lysosome","Neutrophil degranulation; Glycosphingolipid metabolism","Sphingolipid pathway; S1P receptor signal transduction; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway; Sphingolipid metabolism in senescence",7541.1,7358.2,7383.9,6810.9,7121.3,6359.6,1.0981381641845471,0.1350595809768984,0.04384234407950272,1.3581062338672574,0.21754493745898532,0.6624510188259154,1473]
["Q13555-8","Isoform 8 of Calcium/calmodulin-dependent protein kinase type II subunit gamma [OS=Homo sapiens]",27,11,24,9,556,62.1,7.42,70.38,"protein metabolism;other metabolic processes;other biological processes","other cell component","kinase activity;other molecular function","CAMK2G; LOC111145432","ENSCATG00000041481; ENSECAG00000000031; ENSFCAG00000018407; ENSG00000148660; ENSLCNG00005022562; ENSMPUG00000003376; ENSPANG00000022457; ENSPTRG00000002643","ErbB signaling pathway; Calcium signaling pathway; cAMP signaling pathway; HIF-1 signaling pathway; Oocyte meiosis; Necroptosis; Adrenergic signaling in cardiomyocytes; Wnt signaling pathway; Axon guidance; Circadian entrainment; Long-term potentiation; Neurotrophin signaling pathway; Cholinergic synapse; Dopaminergic synapse; Olfactory transduction; Inflammatory mediator regulation of TRP channels; Insulin secretion; GnRH signaling pathway; Melanogenesis; Oxytocin signaling pathway; Glucagon signaling pathway; Aldosterone synthesis and secretion; Cushing syndrome; Gastric acid secretion; Parkinson disease; Pathways of neurodegeneration; Amphetamine addiction; Tuberculosis; Pathways in cancer; Proteoglycans in cancer; Glioma; Diabetic cardiomyopathy; Lipid and atherosclerosis","","Energy metabolism; Myometrial relaxation and contraction pathways; NO/cGMP/PKG mediated neuroprotection; Splicing factor NOVA regulated synaptic proteins; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Disruption of postsynaptic signaling by CNV; Neuroinflammation and glutamatergic signaling; Calcium regulation in cardiac cells; ErbB signaling pathway; Calcium regulation in cardiac cells",2152.7,2140.5,2158,1871.5,1771.1,1723.9,1.2021242895742106,0.265586066333917,1.1777052403471767E-3,2.928963392493782,0.04138388270046882,1.3831687655725704,208]
["Q13564-1","NEDD8-activating enzyme E1 regulatory subunit [OS=Homo sapiens]",54,17,64,17,534,60.2,5.4,215.51,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","NAE1","ENSG00000159593","Alzheimer disease","Neddylation","Alzheimer's disease and miRNA effects; Hijack of ubiquitination by SARS-CoV-2; Alzheimer's disease",5411.2,5469.3,5726.7,5694.2,5645.9,6678.4,0.921674945195216,-0.11767006184694702,0.2501981521923965,0.6017159020591023,0.49184999848688166,0.3081673256110091,3718]
["Q13576-1","Ras GTPase-activating-like protein IQGAP2 [OS=Homo sapiens]",47,62,224,61,1575,180.5,5.64,738.75,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","IQGAP2","ENSG00000145703","Regulation of actin cytoskeleton","CDC42 GTPase cycle; RAC1 GTPase cycle; Neutrophil degranulation; RHOG GTPase cycle; RHO GTPases activate IQGAPs","Ciliary landscape; G13 signaling pathway",24370.4,24357.1,24743.7,21279.9,21419.5,18646.7,1.1976507064018738,0.2602072089454238,0.011353848922321757,1.9448568889232294,0.11184000238982443,0.9514028323182834,742]
["Q13614-1","Myotubularin-related protein 2 [OS=Homo sapiens]",8,3,3,3,643,73.3,7.4,11.38,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MTMR2","ENSG00000087053; ENSGGOG00000010339; ENSPPAG00000042525; ENSPTRG00000004195","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; Synthesis of PIPs at the ER membrane","Intracellular trafficking proteins involved in CMT neuropathy",86.5,71.5,106.7,86.8,87,158,0.7977697408077155,-0.32595569146046477,0.4349103774005775,0.3616002295063405,0.6050171199887363,0.21823233607241907,5254]
["Q13617-1","Cullin-2 [OS=Homo sapiens]",37,25,81,25,745,86.9,6.92,223.45,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction","cytosol;nucleus;other cell component","other molecular function","CUL2","ENSCANG00000032700; ENSCATG00000031722; ENSCCAG00000022671; ENSG00000108094; ENSMFAG00000044478; ENSMMUG00000002469; ENSMNEG00000040111; ENSPANG00000022742; ENSPPYG00000019905","HIF-1 signaling pathway; Ubiquitin mediated proteolysis; Pathways in cancer; Renal cell carcinoma","Antigen processing: Ubiquitination & Proteasome degradation; Regulation of expression of SLITs and ROBOs; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Neddylation","Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2",9361.6,9461.8,9185.4,9142.9,8258.9,7409.4,1.128877281227833,0.17488866114467164,0.10335075447645002,0.9856863486084108,0.33203985251357065,0.478809787717569,2275]
["Q13636","ras-related protein rab-31 [OS=Homo sapiens]",8,1,1,1,194,21.6,7.06,4.1,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","RAB31","ENSG00000168461","Endocytosis","Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation","",24.6,26.2,30.1,22.4,22.6,33.1,1.035851472471191,0.05081715428799844,0.8223118643774459,0.08496344366217631,0.8788240118050521,0.05609808551123328,6839]
["Q13642-1","Isoform 1 of Four and a half LIM domains protein 1 [OS=Homo sapiens]",58,14,55,14,280,31.9,8.32,169.98,"","","","FHL1","","","","",11127.9,10900.3,11119.7,10559.4,10081.4,9983.4,1.0824086833288704,0.11424531810156188,0.012055382577435539,1.918819002737152,0.11413573997211962,0.9425783411889151,772]
["Q13813","Spectrin alpha chain, non-erythrocytic 1 [OS=Homo sapiens]",71,168,1089,1,2472,284.4,5.35,3590.42,"cell organization and biogenesis","non-structural extracellular;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SPTAN1","ENSG00000197694","Apoptosis","Neutrophil degranulation; COPI-mediated anterograde transport; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Interaction between L1 and Ankyrins; RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Caspase-mediated cleavage of cytoskeletal proteins","Fas ligand pathway and stress induction of heat shock proteins",876.4,843.8,861.8,902.9,931,549.1,1.083508182962652,0.11571004911691962,0.6189773547103676,0.20832523935504837,0.731700709296147,0.13566652396995074,6183]
["Q13868","Exosome complex component Rrp4 [OS=Homo sapiens]",25,6,17,6,293,32.8,7.5,62.26,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","EXOSC2","ENSG00000130713","RNA degradation","ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; Major pathway of rRNA processing in the nucleolus and cytosol; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease","Ciliary landscape",1385.8,1429.4,1468,1268,1095.9,764.6,1.369090618507272,0.4532179400540773,0.06181134288192615,1.2089318210437496,0.25352362801571166,0.5959815588606326,1782]
["Q13948","Protein CASP [OS=Homo sapiens]",35,22,48,5,678,77.4,5.44,118.09,"transport","other membranes;ER/Golgi;nucleus","","CUX1","ENSG00000257923","","Intra-Golgi traffic","",512.5,455,501,496.7,533.6,349.8,1.0640533294688792,0.08957045932802617,0.6427141249985096,0.191982155447464,0.7482633863673314,0.12594550492751466,6278]
["Q13951-2","Isoform 2 of Core-binding factor subunit beta [OS=Homo sapiens]",29,5,16,5,187,22,5.58,50.61,"","","","CBFB","","","","",1422.9,1734.6,1302.5,1534.1,1666.9,1018.2,1.0570724307925674,0.08007423383046933,0.7509331860964658,0.12439870241056336,0.8293397789632923,0.08126750335042464,6618]
["Q14061","cytochrome C oxidase copper chaperone [OS=Homo sapiens]",32,2,7,2,63,6.9,7.24,22.8,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","mitochondrion;other cell component","other molecular function","COX17","ENSG00000138495","Oxidative phosphorylation; Metabolic pathways; Thermogenesis","Mitochondrial protein import","Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis; IL-18 signaling pathway; Mitochondrial complex IV assembly",648.4,642.1,631.2,544.4,616.7,614.4,1.0823430019712756,0.11415777164572274,0.11487077715253954,0.939790440724956,0.3457951030510344,0.46118116124420305,2428]
["Q14108-1","Lysosome membrane protein 2 [OS=Homo sapiens]",27,12,78,12,478,54.3,5.14,208.67,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SCARB2","ENSG00000138760","Lysosome","Cargo recognition for clathrin-mediated endocytosis","Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome",10177.2,9870.1,10547.2,8424.2,8813.4,6991.2,1.2627327808228226,0.3365493686818856,0.022534698122619472,1.6471482554123384,0.1552366716100148,0.8090056774297062,1061]
["Q14141-1","Septin-6 [OS=Homo sapiens]",47,19,85,9,434,49.7,6.67,271.65,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component","other molecular function","SEPTIN6","ENSCANG00000016430; ENSCATG00000036060; ENSG00000125354; ENSMLEG00000030428; ENSMMUG00000017669; ENSMNEG00000026932; ENSPANG00000000899; ENSPPAG00000040865; ENSRBIG00000044672; ENSRROG00000038667","Bacterial invasion of epithelial cells; Shigellosis","","",12841.2,12389.7,12267.9,13888.8,13526.6,11628.1,0.9604364362826079,-0.05823795845033034,0.5153675993190422,0.28788288861644834,0.6602667455605398,0.1802805754867088,5705]
["Q14147","Probable ATP-dependent RNA helicase DHX34 [OS=Homo sapiens]",9,6,8,6,1143,128,7.56,16.79,"RNA metabolism OR transcription;other metabolic processes;other biological processes","","other molecular function","DHX34","ENSG00000134815","","","",427.5,465.2,464.6,500,514.5,436.4,{"$f":"AVERAGE(S2946:U2946)/AVERAGE(V2946:X2946)","v":0.935488317595975},{"$f":"LOG(Y2946,2)","v":-0.09620845772444536},{"$f":"TTEST(V2946:X2946,S2946:U2946,2,2)","v":0.31268355722837315},0.5048949559580256,{"$f":"AA2946*7309/AE2946","v":0.5354742548693017},0.27126140482648486,4268]
["Q14164","Inhibitor of nuclear factor kappa-B kinase subunit epsilon [OS=Homo sapiens]",6,4,5,3,716,80.4,7.84,15.39,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","IKBKE","ENSG00000263528","Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Alcoholic liver disease; Hepatitis C; Hepatitis B; Measles; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease; Chemical carcinogenesis; Lipid and atherosclerosis","Negative regulators of DDX58/IFIH1 signaling; SUMOylation of immune response proteins; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; TICAM1-dependent activation of IRF3/IRF7","Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Cardiac hypertrophic response; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Ebola virus pathway in host; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; STING pathway in Kawasaki-like disease and COVID-19; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Toll-like receptor signaling pathway",363,343.9,358.7,353.5,377.3,376.7,0.9621670428893905,-0.05564071125848092,0.22486388130477317,0.6480802973867544,0.4709255325090508,0.3270477624619613,3490]
["Q14197","Peptidyl-tRNA hydrolase ICT1, mitochondrial [OS=Homo sapiens]",8,2,3,2,206,23.6,10.07,7.23,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL58","ENSG00000167862","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",691.7,711.8,501.1,678.9,597.1,447.5,1.1050768784450247,0.14414673911291292,0.5611621830547268,0.2509116039374085,0.6931780287218182,0.15915521133044738,5917]
["Q14204","Cytoplasmic dynein 1 heavy chain 1 [OS=Homo sapiens]",44,185,631,185,4646,532.1,6.4,1919.08,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","DYNC1H1","ENSG00000197102","Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection","Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; COPI-mediated anterograde transport; Neutrophil degranulation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; HCMV Early Events; COPI-independent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Aggrephagy","Ciliary landscape; Intraflagellar transport proteins binding to dynein",68886.1,69223.9,69226.2,64816.8,62724.8,66577,1.0680903324050348,0.09503366631545287,0.017004321779581076,1.7694406852989988,0.13494526372090995,0.8698423536118747,921]
["Q14247-1","Src substrate cortactin [OS=Homo sapiens]",4,2,2,2,550,61.5,5.4,3.99,"cell adhesion;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","CTTN","ENSG00000085733; ENSG00000288401","Tight junction; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Proteoglycans in cancer","Clathrin-mediated endocytosis; RHO GTPases activate PAKs","Pathogenic Escherichia coli infection; Hepatitis C and hepatocellular carcinoma",96.9,106.7,100.2,104,124.9,147.4,0.8073345734786075,-0.30876141956579783,0.1333523821838756,0.8749992217433491,0.3703163227135056,0.43142714480129396,2632]
["Q14331","Protein FRG1 [OS=Homo sapiens]",24,6,20,6,258,29.2,9.01,52.02,"RNA metabolism OR transcription;other metabolic processes;developmental processes","cytoskeleton;nucleus","cytoskeletal activity","FRG1","ENSG00000109536; ENSG00000275145; ENSG00000283153; ENSG00000283630","","","",2953.2,2934.1,3004,3293.6,3663.9,2507.4,0.9393971410157529,-0.0901928920183722,0.6055411840024496,0.21785631432644023,0.7222422509585352,0.14131710906701483,6128]
["Q14376","UDP-glucose 4-epimerase [OS=Homo sapiens]",40,12,41,12,348,38.3,6.73,131.26,"other metabolic processes","cytosol","other molecular function","GALE","ENSG00000117308","Galactose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars","Galactose catabolism; Defective GALE can cause Epimerase-deficiency galactosemia (EDG)","",4219.7,4011.8,4119.4,3726.5,3343.9,2820,1.2487765914422067,0.32051539908543686,0.03828359511262179,1.4169872855174355,0.20364977924174138,0.6911160563569941,1374]
["Q14498-1","RNA-binding protein 39 [OS=Homo sapiens]",31,13,35,13,530,59.3,10.1,115.7,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","LOC101348913; LOC111141906; LOC112827340; Rbm39; RBM39","ENSAMEG00000009940; ENSANAG00000024610; ENSBIXG00000021585; ENSBIXG00005010311; ENSBMUG00000009739; ENSCAFG00000008327; ENSCCAG00000031689; ENSDLEG00000014321; ENSECAG00000013423; ENSFCAG00000003233; ENSG00000131051; ENSGGOG00000003950; ENSHGLG00000017871; ENSLAFG00000010346; ENSLCNG00005002645; ENSMMUG00000031284; ENSMNEG00000040217; ENSMPUG00000017786; ENSOCUG00000007050; ENSPCOG00000027976; ENSPCTG00005007206; ENSPPAG00000029710; ENSPPYG00000010963; ENSPTRG00000049720; ENSRBIG00000044413; ENSRFEG00010016851; ENSRROG00000037484; ENSSSCG00000007309; ENSSSCG00070008152; ENSSSUG00005008586; ENSTTRG00000017039; ENSUAMG00000010443; ENSUMAG00000004302; ENSVVUG00000001290","","","mRNA Processing; VEGFA-VEGFR2 signaling pathway; mRNA processing; mRNA Processing",5366.4,5382,5309.2,5212.6,6166.1,4166.8,1.0329420089414942,0.04675926121073741,0.7823571983513897,0.1065949172034231,0.8534699645895982,0.06881175802027652,6700]
["Q14554","Protein disulfide-isomerase A5 [OS=Homo sapiens]",40,16,47,16,519,59.6,7.91,140.49,"other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","PDIA5","ENSG00000065485","","XBP1(S) activates chaperone genes","",4382.4,4294.3,4510.8,4043,3801.8,3816.4,1.1308870442150034,0.17745483658764144,0.007102658195408022,2.1485790845845893,0.09012730685805076,1.0451436061238284,576]
["Q14596-1","Next to BRCA1 gene 1 protein [OS=Homo sapiens]",7,4,4,4,966,107.3,5.12,7.5,"other metabolic processes;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","NBR1","ENSG00000188554","Mitophagy","Pexophagy","",154.2,139.6,163.2,229.7,259.2,444.7,0.4895029991431019,-1.0306103957619162,0.07863054562106973,1.10440871073336,0.287787009486429,0.5409288137200896,1997]
["Q14671-3","Isoform 3 of Pumilio homolog 1 [OS=Homo sapiens]",12,12,15,8,1188,126.6,6.84,37.44,"","","","PUM1","","","","",982.2,965.6,1051.3,1799.8,1716.3,1951.3,{"$f":"AVERAGE(S3010:U3010)/AVERAGE(V3010:X3010)","v":0.5485422687200499},{"$f":"LOG(Y3010,2)","v":-0.8663253010168604},{"$f":"TTEST(V3010:X3010,S3010:U3010,2,2)","v":3.6481653646147373E-4},3.4379254841287112,{"$f":"AA3010*7309/AE3010","v":0.022790120213648818},1.6422533839908997,117]
["Q14677-1","Clathrin interactor 1 [OS=Homo sapiens]",31,20,83,20,625,68.2,6.42,237.51,"cell organization and biogenesis;transport","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","CLINT1","ENSG00000113282","","Golgi Associated Vesicle Biogenesis","",8927.9,8690.2,9278.6,10207.1,10175.5,16984.9,0.7197885863383956,-0.4743548692064782,0.19913175355273408,0.7008594818451839,0.44509296229875633,0.351549272621497,3270]
["Q14692","ribosome biogenesis protein BMS1 homolog [OS=Homo sapiens]",16,16,27,16,1282,145.7,6.44,68.05,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","BMS1","ENSG00000165733","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",1394.4,1371.8,1369.5,3833.4,3706.4,4388.9,0.34670165231751987,-1.5282333827059713,2.4417534047338821E-4,3.6122981980369078,0.019829750705777718,1.7026827455922595,90]
["Q14764","major vault protein [OS=Homo sapiens]",62,42,250,42,893,99.3,5.48,824.62,"transport;signal transduction;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","MVP","ENSG00000013364","","Neutrophil degranulation","16p11.2 proximal deletion syndrome",28027.1,28265.1,27808.7,28437.7,28053.5,26598.7,1.0121675438290334,0.017448118732512195,0.589514889942816,0.22950522103821633,0.7114868445495446,0.14783312564625972,6056]
["Q14790-4","Isoform 4 of Caspase-8 [OS=Homo sapiens]",50,20,54,9,496,57.7,5.43,187.15,"","","","CASP8","","","","",5167.6,5197.9,5281.4,5193.2,5170.8,4414.9,1.0587323819770078,0.08233796233586205,0.3249273512546906,0.4882137297168028,0.5438273437876193,0.26453895975416997,4367]
["Q14849-1","StAR-related lipid transfer protein 3 [OS=Homo sapiens]",13,4,8,4,445,50.5,8.37,16.7,"cell organization and biogenesis;other metabolic processes;transport","other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","STARD3","ENSG00000131748","Cholesterol metabolism","Pregnenolone biosynthesis","",320,337.9,360.8,281.3,258.6,314.9,1.1917407580720636,0.2530704373771274,0.05361739668392523,1.2706942763891884,0.237652851645124,0.6240569701497342,1649]
["Q14966-1","Zinc finger protein 638 [OS=Homo sapiens]",19,29,48,29,1978,220.5,6.38,116.6,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF638","ENSG00000075292","","Transcriptional regulation of white adipocyte differentiation","",3780.2,3813.3,3764.9,4877,5079.3,5580.3,0.7310737226935109,-0.4519111975996346,2.6594757061764274E-3,2.5752039725258453,0.0573395514349366,1.2415457088449546,339]
["Q14999","Cullin-7 [OS=Homo sapiens]",2,3,3,1,1698,191,5.87,8.39,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","CUL7","ENSG00000044090","Ubiquitin mediated proteolysis","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; XBP1(S) activates chaperone genes","",34.2,36.6,28.5,45.8,42.9,94.5,0.5420305676855895,-0.88355388056857,0.17348243504440944,0.7607444906106153,0.4150517570342352,0.3818977433052155,3055]
["Q15006","ER membrane protein complex subunit 2 [OS=Homo sapiens]",34,8,35,8,297,34.8,6.57,87.91,"cell organization and biogenesis","other membranes;ER/Golgi;other cell component","","EMC2","ENSG00000104412","","","",2021.1,1960.3,2063.3,1963.4,1900.8,1417.7,1.144417728468922,0.19461375210621107,0.21986980573879975,0.6578344072985433,0.4655354606445213,0.3320472324577422,3452]
["Q15011-3","Isoform 3 of Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein [OS=Homo sapiens]",22,4,10,4,232,26.2,5.77,25.63,"","","","HERPUD1","","","","",627.5,666.8,708,1239.3,1190.9,1768.9,0.4768402752970874,-1.0684219997805493,0.01718013049096004,1.7649735418267405,0.13560429131579582,0.8677265666247018,926]
["Q15022","Polycomb protein suz12 [OS=Homo sapiens]",9,5,9,5,739,83,8.81,24.37,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","SUZ12","ENSG00000178691","","HCMV Early Events; Oxidative Stress Induced Senescence; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PRC2 methylates histones and DNA; Defective pyroptosis; PKMTs methylate histone lysines; SUMOylation of chromatin organization proteins; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6","Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Malignant pleural mesothelioma",1230.1,1192.1,1184.1,1606.7,1532.8,1417.3,0.7914106390449437,-0.3375016350932877,0.005099234199221494,2.2924950411618052,0.07929851651512744,1.1007349372135495,470]
["Q15042-1","Rab3 GTPase-activating protein catalytic subunit [OS=Homo sapiens]",39,31,82,31,981,110.5,5.55,233.69,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","RAB3GAP1","ENSG00000115839","","RAB GEFs exchange GTP for GDP on RABs; COPI-independent Golgi-to-ER retrograde traffic","",7395.9,7486.1,7560.2,7642.9,7442.1,7011.4,1.0156496080809543,0.022402768377395545,0.5810911824434876,0.23575571455467215,0.7070410275477694,0.1505553846180544,6007]
["Q15043","Zinc transporter ZIP14 [OS=Homo sapiens]",9,4,5,4,492,54.2,5.33,18.12,"other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle","transporter activity","SLC39A14","ENSG00000104635","Ferroptosis; Alzheimer disease; Parkinson disease","Zinc influx into cells by the SLC39 gene family","Nuclear receptors meta-pathway; NRF2 pathway; Zinc homeostasis; Ferroptosis",512.7,541,534.3,557,597.2,630.6,0.8897355445988345,-0.16855150621382056,0.04586607143256029,1.338508456908075,0.22098557422582935,0.6556360758108325,1517]
["Q15056-1","Eukaryotic translation initiation factor 4H [OS=Homo sapiens]",38,8,31,8,248,27.4,7.23,82.22,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","translation activity;nucleic acid binding activity","EIF4H","ENSG00000106682; ENSPTRG00000019287","","L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Ribosomal scanning and start codon recognition","Translation factors; 7q11.23 copy number variation syndrome",3192.7,2611,2283,3574,2889.1,2917.6,0.8620572025541804,-0.21414449111458436,0.2823952497330316,0.5491426129746361,0.5163940155863718,0.28701879935076796,3997]
["Q15061","WD repeat-containing protein 43 [OS=Homo sapiens]",30,17,45,17,677,74.8,5.57,106.65,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","WDR43","ENSG00000163811","Ribosome biogenesis in eukaryotes","rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol","",4010,3945,3956.8,4643.9,4496.7,5180.7,0.831754100535566,-0.26577102129621094,0.01836059100054429,1.7361133436062222,0.1411120500767384,0.8504358986596631,951]
["Q15102","Platelet-activating factor acetylhydrolase IB subunit gamma [OS=Homo sapiens]",41,8,32,8,231,25.7,6.84,85.33,"other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","other molecular function","PAFAH1B3","ENSG00000079462","Ether lipid metabolism; Metabolic pathways","COPI-independent Golgi-to-ER retrograde traffic","",3757.2,3864.6,3765.4,3711.7,3616.1,4676.9,0.9485618132897949,-0.07618630457065396,0.5781719191769887,0.23794300509467586,0.7053678112609932,0.15158436280106793,5991]
["Q15126","phosphomevalonate kinase [OS=Homo sapiens]",78,12,44,12,192,22,5.73,115.47,"other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle","kinase activity;other molecular function","PMVK","ENSG00000163344","Terpenoid backbone biosynthesis; Metabolic pathways; Peroxisome","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Cholesterol biosynthesis pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways",6104.1,6173.5,5944.1,6193.4,5898.1,4596.7,1.0918912764707998,0.12682920909160408,0.3602474695359537,0.4433990610911602,0.55927118836837,0.25237755337858425,4708]
["Q15154-1","Pericentriolar material 1 protein [OS=Homo sapiens]",31,44,79,44,2024,228.4,5.02,213.04,"","","","","","","","",5875.4,5964.9,5871,8225.3,8400.7,8339,0.7094452233126377,-0.4952367976430575,2.2342679110554808E-6,5.650864751848496,0.008165132080952254,2.088036785628504,2]
["Q15185","Prostaglandin E synthase 3 [OS=Homo sapiens]",56,9,100,9,160,18.7,4.54,330.43,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","PTGES3","ENSG00000110958","Arachidonic acid metabolism; Metabolic pathways; Chemical carcinogenesis","HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Estrogen-dependent gene expression; Potential therapeutics for SARS; HSF1 activation; Aryl hydrocarbon receptor signalling; Synthesis of Prostaglandins (PG) and Thromboxanes (TX); Attenuation phase","Aryl hydrocarbon receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway",15892,15810.2,14313.8,15081.2,15758,10466.6,1.1140324119130969,0.155791207387149,0.41786738201523244,0.3789615277883195,0.592471909825283,0.22733223552388188,5155]
["Q15291-1","Retinoblastoma-binding protein 5 [OS=Homo sapiens]",36,14,34,14,538,59.1,5.1,104.98,"protein metabolism;other metabolic processes;stress response;other biological processes","nucleus","nucleic acid binding activity;other molecular function","LOC101350636; RBBP5","ENSANAG00000037817; ENSBIXG00000017360; ENSBIXG00005000379; ENSBTAG00000015946; ENSCANG00000035291; ENSCHIG00000014205; ENSCJAG00000017172; ENSCSAG00000014601; ENSG00000117222; ENSGGOG00000014796; ENSLCNG00005015908; ENSMFAG00000038790; ENSMLEG00000013766; ENSMMUG00000018803; ENSMNEG00000044153; ENSNLEG00000014409; ENSPANG00000015342; ENSPPAG00000004153; ENSPPYG00000000310; ENSPTRG00000001894; ENSRBIG00000028065; ENSRFEG00010013463; ENSRROG00000045061; ENSSSCG00070019803; ENSSSUG00005002678; ENSTSYG00000000255","Cushing syndrome","Formation of the beta-catenin:TCF transactivating complex; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Neddylation; PKMTs methylate histone lysines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Neddylation; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","",2322.3,2346.2,2454.2,2166.4,2120.1,3806.2,0.8801388906051132,-0.18419688821000818,0.5920511245166322,0.22764078966762044,0.7125476155264392,0.1471861089062109,6073]
["Q15293","Reticulocalbin-1 [OS=Homo sapiens]",48,12,47,12,331,38.9,5,138.54,"","ER/Golgi","other molecular function","RCN1","ENSG00000049449","","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","VEGFA-VEGFR2 signaling pathway",7167.7,4134.3,3077.2,6474.4,3947.3,3689.5,1.0189920063495663,0.027142734089523595,0.955778437096227,0.019642771634598728,0.9720028658322419,0.01233245460737364,7187]
["Q15365","Poly(RC)-binding protein 1 [OS=Homo sapiens]",71,18,365,11,356,37.5,7.09,1369.44,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PCBP1","ENSG00000169564","Spliceosome; Ferroptosis","mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA","Ferroptosis",31793.9,31791.7,32756.2,34548,34031,31053.3,0.9669735617866896,-0.04845164965334917,0.3887217535909377,0.41036115476324847,0.5717784860125104,0.24277218962480826,4969]
["Q15369-1","elongin-C [OS=Homo sapiens]",48,4,18,4,112,12.5,4.78,67.62,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","eloc; Eloc; ELOC; eloc.L; LOC101358566; LOC105890220; LOC107550711; LOC107664095; LOC107751353; LOC111156807; LOC113045545; LOC113937395; LOC115195324; Tceb1; TCEB1","ENSACCG00020004765; ENSACUG00000011303; ENSAMEG00000012854; ENSANAG00000026963; ENSBIXG00000018463; ENSBIXG00005018332; ENSBTAG00000050514; ENSCAFG00000008152; ENSCATG00000020385; ENSCATG00000034779; ENSCCAG00000008410; ENSCCAG00000023220; ENSCGRG00001001449; ENSCHIG00000015198; ENSCPOG00000032030; ENSCPRG00005018410; ENSCSAG00000013512; ENSDLEG00000009234; ENSECAG00000000064; ENSEGOG00005000341; ENSELUG00000027740; ENSFCAG00000032823; ENSG00000154582; ENSGAGG00000025908; ENSGALG00000035417; ENSGGOG00000002188; ENSHGLG00000016964; ENSHHUG00000007733; ENSLCNG00005018064; ENSLSDG00000013506; ENSMFAG00000038428; ENSMMDG00005018719; ENSMNEG00000033021; ENSMODG00000006970; ENSMPUG00000010207; ENSMUSG00000079658; ENSOCUG00000032655; ENSOMYG00000017295; ENSOMYG00000030379; ENSPANG00000016947; ENSPCOG00000017567; ENSPCTG00005011391; ENSPMRG00000007569; ENSPPAG00000004063; ENSPPYG00000018678; ENSPSIG00000003701; ENSPTRG00000045560; ENSPTRG00000046987; ENSPTXG00000006319; ENSRBIG00000038767; ENSRFEG00010008700; ENSRNOG00000031730; ENSRROG00000031208; ENSSANG00000000802; ENSSANG00000018252; ENSSBOG00000024839; ENSSFOG00015012880; ENSSFOG00015024826; ENSSGRG00000038413; ENSSGRG00000052876; ENSSHAG00000009970; ENSSHBG00005007386; ENSSRHG00000026121; ENSSRHG00000030142; ENSSSAG00000055027; ENSSSCG00070017636; ENSSSUG00005020214; ENSSTUG00000043851; ENSTMTG00000005512; ENSTSYG00000035894; ENSUAMG00000019951; ENSVURG00010016846; ENSVURG00010021344; ENSXETG00000011828","HIF-1 signaling pathway; Ubiquitin mediated proteolysis; Human immunodeficiency virus 1 infection; Pathways in cancer; Renal cell carcinoma","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Neddylation; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Inactivation of CSF3 (G-CSF) signaling; RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex ; TP53 Regulates Transcription of DNA Repair Genes; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Neddylation; Inactivation of CSF3 (G-CSF) signaling; Neddylation; Antigen processing: Ubiquitination & Proteasome degradation; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Inactivation of CSF3 (G-CSF) signaling; Neddylation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Antigen processing: Ubiquitination & Proteasome degradation; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Inactivation of CSF3 (G-CSF) signaling; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; TP53 Regulates Transcription of DNA Repair Genes; RNA Polymerase II Pre-transcription Events; RNA Polymerase II Transcription Elongation; Inactivation of CSF3 (G-CSF) signaling; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Inactivation of CSF3 (G-CSF) signaling; RNA Polymerase II Pre-transcription Events; Neddylation; Antigen processing: Ubiquitination & Proteasome degradation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA Polymerase II Transcription Elongation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Dual hijack model of Vif in HIV infection; VEGFA-VEGFR2 signaling pathway; Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2",1188.3,1374.7,1336,1690.6,1498.7,1803.2,0.7809714571857787,-0.3566582729336991,0.025923714371602787,1.5863027722644103,0.1667926305827859,0.7778231417554374,1136]
["Q15393-1","Splicing factor 3B subunit 3 [OS=Homo sapiens]",41,40,162,40,1217,135.5,5.26,514.36,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","Sf3b3; SF3B3","ENSANAG00000028001; ENSBIXG00000000514; ENSBTAG00000010627; ENSCATG00000036562; ENSCCAG00000017736; ENSCJAG00000014773; ENSG00000189091; ENSGGOG00000003246; ENSHGLG00000010135; ENSMFAG00000045487; ENSMMUG00000017812; ENSMNEG00000033385; ENSPANG00000024075; ENSPPAG00000026807; ENSPTRG00000008308; ENSRBIG00000021904; ENSRROG00000045703; ENSSBOG00000029156; ENSSTOG00000007065; ENSTSYG00000007910","Spliceosome","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","mRNA Processing; mRNA processing; mRNA Processing",16989.9,17747.1,16996.5,17615.3,17328.4,16420.1,1.0071976761843944,0.010346859574335105,0.7929561306312696,0.10075083885109164,0.8606647399441565,0.06516598901918844,6734]
["Q15435","Protein phosphatase 1 regulatory subunit 7 [OS=Homo sapiens]",44,13,38,13,360,41.5,4.91,122.15,"other biological processes","other cell component","enzyme regulator activity","PPP1R7","ENSG00000115685","","","",3880.6,3783.8,3896.6,3770.2,3464.7,2813.1,1.150577229299363,0.20235782370784863,0.1508968625616343,0.821319789954925,0.3894439154177207,0.4095550770886835,2832]
["Q15438-1","Cytohesin-1 [OS=Homo sapiens]",32,13,35,9,398,46.4,5.54,109.11,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","CYTH1","ENSCATG00000038229; ENSG00000108669; ENSMFAG00000037544; ENSMMUG00000013313; ENSPANG00000019854; ENSPTRG00000009717","Phospholipase D signaling pathway; Endocytosis; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection","Intra-Golgi traffic","",2216.9,2365.8,2227.8,2761.8,2910.7,4420.9,0.6747478550339827,-0.5675796093927229,0.10888739105484074,0.9630224077772624,0.33765716640637716,0.4715240284176133,2357]
["Q15542","Transcription initiation factor TFIID subunit 5 [OS=Homo sapiens]",16,8,24,8,800,86.8,5.64,63.3,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","TAF5","ENSG00000148835","Basal transcription factors","RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Regulation of TP53 Activity through Phosphorylation","Eukaryotic transcription initiation",1112.8,1161.5,1122.6,1224.8,1114.7,790.2,1.0853755951049622,0.11819437486086712,0.5347476189321534,0.2718511405328328,0.6741066482882216,0.17127138966783848,5798]
["Q15633","RISC-loading complex subunit TARBP2 [OS=Homo sapiens]",2,1,1,1,366,39,6.54,2.9,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TARBP2","ENSG00000139546","","MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis","Fragile X syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies",72.5,72.1,82.6,105.2,99.5,154.4,0.632692843219159,-0.6604228181599763,0.06856639575126051,1.1638886789797036,0.26742357873317135,0.57280030364749,1874]
["Q15637-5","Isoform 5 of Splicing factor 1 [OS=Homo sapiens]",24,12,53,12,673,71.7,9.58,169.22,"","","","SF1","","","","",5550.5,5570.1,5133.1,6633.8,7174.9,6158.3,0.8140281464416287,-0.2968494158384395,0.0192372763992188,1.7158564150694855,0.1445069405980372,0.8401112934538645,973]
["Q15654-1","thyroid receptor-interacting protein 6 [OS=Homo sapiens]",3,1,1,1,476,50.3,7.37,2.8,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","TRIP6","ENSG00000087077","NOD-like receptor signaling pathway","","",19.2,18.3,20.4,20,19.7,23.4,0.9175911251980983,-0.12407665699331238,0.26345159647122385,0.5792991653335833,0.501319374800358,0.2998855106147864,3841]
["Q15696","U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 [OS=Homo sapiens]",10,4,6,4,482,58,9.72,17.05,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","ZRSR2","ENSG00000169249","","mRNA Splicing - Minor Pathway","",292.4,313.3,301,292.7,330.3,269.7,1.0156827601657892,0.02244985899549264,0.8149764502849224,0.08885494053496233,0.8745650969215237,0.058207858933598075,6811]
["Q15771","Ras-related protein Rab-30 [OS=Homo sapiens]",55,11,24,9,203,23,4.97,71.5,"cell organization and biogenesis;signal transduction","other membranes;ER/Golgi;other cell component","other molecular function","RAB30","ENSG00000137502","","Intra-Golgi traffic; RAB geranylgeranylation","",2263.3,2286.8,2373.4,2138.6,2119.3,2121,1.0853752214331627,0.11819387817147473,0.005954477737674633,2.225156324121192,0.08401791078120444,1.0756281219824517,518]
["Q15811-8","Isoform 8 of Intersectin-1 [OS=Homo sapiens]",7,11,19,1,1716,194.7,7.77,55.22,"","","","ITSN1","","","","",1650.3,1630.6,1576.2,1830.6,1785,1324.4,0.9832186234817811,-0.02441585233550412,0.8737473800404474,0.05861411349024778,0.9186161681121446,0.036865915046884905,6952]
["Q15843","NEDD8 [OS=Homo sapiens]",36,4,24,4,81,9.1,8.43,57.78,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","NEDD8","ENSG00000129559; ENSG00000285246","","Cargo recognition for clathrin-mediated endocytosis; UCH proteinases; Neddylation; Iron uptake and transport; TGF-beta receptor signaling activates SMADs","EGF/EGFR signaling pathway",2906.1,3061.8,2730.6,3109.4,3023.6,4198.4,0.8419478483071027,-0.24819722183189616,0.23533659410468497,0.6283105361387061,0.4804679235505984,0.3183356008986076,3580]
["Q15904","V-type proton ATPase subunit S1 [OS=Homo sapiens]",9,3,5,3,470,52,6.14,14.3,"transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","ATP6AP1","ENSG00000071553","Oxidative phosphorylation; Metabolic pathways; Lysosome; Phagosome; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Tuberculosis; Hepatitis B; Human papillomavirus infection; Rheumatoid arthritis","Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport; RHOA GTPase cycle","Hepatitis B infection; Oxidative phosphorylation",665.5,684,708,529.8,496.7,329.2,1.5176661503282436,0.6018544678041906,0.020911883609918077,1.6796068469264516,0.14970123144455558,0.8247746271293886,1021]
["Q16254","Transcription factor E2F4 [OS=Homo sapiens]",11,4,4,4,413,43.9,4.75,14.49,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","E2F4","ENSG00000205250","Cell cycle; Cellular senescence; TGF-beta signaling pathway","Cyclin D associated events in G1; G1/S-Specific Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest","Cell cycle; Adipogenesis; TGF-beta signaling pathway",405.5,436.4,393.3,512.9,538.4,462.5,0.8159598361738671,-0.29342995442937614,0.02255863728967094,1.6466871385296122,0.1552552541904001,0.8089536933910896,1062]
["Q16401","26S proteasome non-ATPase regulatory subunit 5 [OS=Homo sapiens]",46,16,61,16,504,56.2,5.48,181.89,"cell organization and biogenesis","cytosol;nucleus;other cell component","","PSMD5","ENSG00000095261","","Degradation of DVL; Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Parkin-ubiquitin proteasomal system pathway",7029.3,6879.8,6990.3,6357.4,6393.7,5341.4,1.155141633273456,0.20806975302136338,0.0546364970852727,1.262517152395761,0.24071016105862456,0.6185055765361487,1659]
["Q16540","39S ribosomal protein L23, mitochondrial [OS=Homo sapiens]",13,1,1,1,153,17.8,9.69,2.29,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus","nucleic acid binding activity;other molecular function","MRPL23","ENSG00000214026; ENSG00000288141","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",22.5,22.4,24.5,21.5,27,58.3,0.649812734082397,-0.621904079109293,0.3386014427142628,0.470311195779628,0.5487445553877044,0.2606297757736155,4510]
["Q16563","Synaptophysin-like protein 1 [OS=Homo sapiens]",10,2,2,2,259,28.5,8.43,6.69,"cell-cell signaling","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","SYPL1","ENSG00000008282","","","",329.7,315.7,290.9,307,370.5,360.5,0.9020231213872831,-0.14876368060487688,0.21034271867932836,0.6770725171250964,0.45565943415151483,0.3413596334942298,3374]
["Q16629","serine/arginine-rich splicing factor 7 [OS=Homo sapiens]",37,11,91,10,238,27.4,11.82,225.6,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","nucleus;other cell component","other molecular function","SRSF7","ENSG00000115875","Spliceosome; Amyotrophic lateral sclerosis; Herpes simplex virus 1 infection","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Minor Pathway","mRNA processing",12131.6,11903.1,11976.5,11498.8,12349.7,12064.5,1.0027343858769804,0.003939501337430283,0.9055102954967281,0.04310660746809115,0.9402436070159945,0.02675961078736636,7039]
["Q16690","Dual specificity protein phosphatase 5 [OS=Homo sapiens]",6,1,1,1,384,42,8.35,3.41,"protein metabolism;other metabolic processes;developmental processes;signal transduction","nucleus;other cell component","other molecular function","DUSP5","ENSG00000138166","MAPK signaling pathway","Negative regulation of MAPK pathway; RAF-independent MAPK1/3 activation","Endoderm differentiation; VEGFA-VEGFR2 signaling pathway",14.5,16.7,16.5,34.1,31.9,62.5,0.37120622568093387,-1.429707188075729,0.05263959282378125,1.2786874787229172,0.23560488912983293,0.6278157015756123,1633]
["Q16763","ubiquitin-conjugating enzyme E2 S [OS=Homo sapiens]",18,4,6,4,222,23.8,8.38,19.55,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","UBE2S","ENSG00000108106","Ubiquitin mediated proteolysis","APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; APC-Cdc20 mediated degradation of Nek2A; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; APC/C:Cdc20 mediated degradation of Securin; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","",589.5,703,546.9,533.5,584,2408.6,0.5216528175604777,-0.9388381444617367,0.4147853358691294,0.38217660585988456,0.5901627447668808,0.2290282097002488,5137]
["Q16774-1","guanylate kinase [OS=Homo sapiens]",47,8,28,8,197,21.7,6.55,84.33,"other metabolic processes;transport","cytosol;other cell component","kinase activity;other molecular function","GUK1","ENSG00000143774","Purine metabolism; Metabolic pathways","Interconversion of nucleotide di- and triphosphates; Abacavir metabolism","",3790.8,4120.7,3606.5,3237.1,3625.1,1651.9,1.352814742603446,0.4359642870404486,0.18273166932085452,0.7381861783213332,0.4258883198552697,0.37070427044976095,3136]
["Q16854","Deoxyguanosine kinase, mitochondrial [OS=Homo sapiens]",3,1,3,1,277,32,8.66,8.22,"protein metabolism;other metabolic processes;other biological processes","cytosol;mitochondrion;other cell component","kinase activity;other molecular function","DGUOK","ENSG00000114956","Purine metabolism; Metabolic pathways","Purine salvage","",183.2,167.6,186.5,151.5,140.2,163.8,1.179582875960483,0.23827678401770425,0.03837579580054829,1.415942605437798,0.20369549128991102,0.6910185838107485,1377]
["Q16864-1","V-type proton ATPase subunit F [OS=Homo sapiens]",33,3,7,3,119,13.4,5.52,19.7,"transport","other membranes;cytosol;other cytoplasmic organelle","transporter activity;other molecular function","ATP6V1F","ENSCATG00000033101; ENSG00000128524; ENSGGOG00000023527; ENSMLEG00000037581; ENSPPAG00000012238; ENSPPAG00000027671; ENSPTRG00000019672; ENSPTRG00000040903","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis","ROS and RNS production in phagocytes; Amino acids regulate mTORC1; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Proximal tubule transport",806.6,1150.9,746.9,995.1,1154.3,1079.6,0.8375348405078973,-0.25577888868931137,0.2620218822336809,0.5816624379302456,0.5014710492919544,0.2997541344195904,3819]
["Q17RN3-1","Protein Fam98c [OS=Homo sapiens]",5,2,3,2,349,37.3,7.18,6.77,"","other cell component","","FAM98C","ENSG00000130244","","","",173.7,185.6,154.8,173.7,190.4,409.7,0.6643835616438355,-0.5899117166928899,0.32140000760900755,0.49295411729093824,0.5420195329059152,0.2659850623907644,4334]
["Q29963","HLA class I histocompatibility antigen, Cw-6 alpha chain [OS=Homo sapiens]",46,14,120,3,366,40.9,6,477.31,"other biological processes","plasma membrane;other membranes","","HLA-C","ENSG00000228299","","","",12429.6,12148.8,13173.3,10055.8,10727.7,17440.5,0.9876438886563415,-0.017937146883802796,0.9503777515595826,0.022103739122142974,0.9682619161066336,0.014007149578117788,7174]
["Q2KHR3-1","Glutamine and serine-rich protein 1 [OS=Homo sapiens]",0,1,1,1,1735,189.9,7.08,0,"","","","QSER1","ENSG00000060749","","","",15,12,12.5,15.7,15.6,13.1,0.8896396396396397,-0.16870702328564066,0.2642026609623088,0.5780628126282757,0.5018340044109967,0.2994399141100781,3848]
["Q2NKX8","Dna excision repair protein ercc-6-like [OS=Homo sapiens]",23,21,34,21,1250,141,5.31,102.91,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","ERCC6L","ENSG00000186871","","RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",2409.2,2522.5,2449.2,2524.6,2567.5,5268.8,0.7123801986313929,-0.48928067914030443,0.3355518158797396,0.47424040660356204,0.5475660241716939,0.2615635071642769,4479]
["Q2TAL8","Glutamine-rich protein 1 [OS=Homo sapiens]",6,4,7,4,776,86.4,5.87,22.38,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cell component","nucleic acid binding activity","QRICH1","ENSG00000198218","","","",626,659,676.3,759.8,692.5,536.7,0.9860734037204625,-0.020233049458814205,0.8981023226766816,0.04667418043481906,0.9357419638551483,0.028843893915224822,7015]
["Q2TB10","zinc finger protein 800 [OS=Homo sapiens]",21,12,19,12,664,75.2,9.47,45.09,"","nucleus","nucleic acid binding activity;other molecular function","ZNF800","ENSG00000048405","","","",1345.6,1353.2,1339.1,1635.6,1579.6,1762.9,0.8111327614953496,-0.3019900291803355,0.004499362465548832,2.346849018960045,0.0740672077943613,1.1303740271906917,444]
["Q32MZ4-3","Isoform 3 of Leucine-rich repeat flightless-interacting protein 1 [OS=Homo sapiens]",52,30,133,27,752,82.6,4.61,441.23,"","","","LRRFIP1","","","","",11502.8,11589,10262.1,14100.8,14601.2,13843.5,0.7839583504718478,-0.3511510848885051,0.003161729801128964,2.5000752472731036,0.0622886337370663,1.2055911950041764,371]
["Q32P28-1","Prolyl 3-hydroxylase 1 [OS=Homo sapiens]",4,3,6,3,736,83.3,5.14,16.19,"protein metabolism;other metabolic processes;developmental processes;other biological processes","ER/Golgi;nucleus;other cell component","other molecular function","P3H1","ENSG00000117385","","Collagen biosynthesis and modifying enzymes","Type I collagen synthesis in the context of osteogenesis imperfecta",703.4,688.1,704.2,687.9,732.5,557.1,1.059772439949431,0.08375451478745151,0.4977133436805614,0.30302071567720984,0.647523465461236,0.18874448865879614,5618]
["Q3B820-3","Isoform 3 of Protein FAM161A [OS=Homo sapiens]",5,3,4,2,716,83.4,8.66,10.04,"","","","FAM161A","","","","",50.7,59.8,48.7,86,83.5,90.5,0.6123076923076922,-0.7076712873721683,1.081183123502886E-3,{"$f":"-LOG10(AA3331)","v":2.96610074194739},0.04031820127389078,{"$f":"-LOG10(AC3331)","v":1.3944988514198935},196]
["Q3MHD2","Protein LSM12 homolog [OS=Homo sapiens]",18,4,11,4,195,21.7,7.74,27.54,"","","","LSM12","ENSG00000161654","","","",806.6,1038.6,866,1263.9,1260.4,1284.1,0.7119000105030984,-0.49025347234937844,0.006396861148802297,2.1940330760392652,0.08626320689408855,1.0641744006936793,542]
["Q3SXM5","Inactive hydroxysteroid dehydrogenase-like protein 1 [OS=Homo sapiens]",9,3,13,3,330,37,8.72,40.46,"","cytoskeleton;mitochondrion;other cell component","other molecular function","HSDL1","ENSG00000103160","","","",1194.9,1263.9,1172.1,1079.3,900.2,901.6,1.2602478220124258,0.33370746105262317,0.01890226796855189,1.7234860843381428,0.14331605454579435,0.8437051563570005,964]
["Q460N5-1","Isoform 1 of Poly [ADP-ribose] polymerase 14 [OS=Homo sapiens]",3,3,3,3,1720,193.6,7.97,6.48,"","","","PARP14","","","","",46.5,37.4,45.2,46.5,52.5,57.8,0.8233418367346939,-0.2804365588080176,0.0998088515235491,1.0008309417049213,0.3258163893638322,0.48702707339997847,2239]
["Q49MG5","Microtubule-associated protein 9 [OS=Homo sapiens]",2,2,3,2,647,74.2,7.8,3.64,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;other cell component","cytoskeletal activity","MAP9","ENSG00000164114","","","",454.5,849.7,491.1,672.8,630.8,260.3,1.147963424771405,0.19907667708197463,0.6932807773041301,0.159090841379881,0.7845160553206203,0.10539816403905768,6459]
["Q4G0F5","Vacuolar protein sorting-associated protein 26B [OS=Homo sapiens]",25,9,32,7,336,39.1,7.36,93.1,"stress response;transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","VPS26B","ENSG00000151502","Endocytosis","","",2717.9,2761.9,2750.4,2717.9,2493.8,1622.7,1.2042315345897225,0.2681128021394805,0.23639171828929254,0.626367742529629,0.48141183309457763,0.3174832389788959,3589]
["Q4KMP7","TBC1 domain family member 10B [OS=Homo sapiens]",21,13,41,13,808,87.1,9.19,100.53,"transport;other biological processes","plasma membrane;other membranes;cytosol","enzyme regulator activity","TBC1D10B","ENSG00000169221","","TBC/RABGAPs","",2557,2552.8,2590.4,2559.6,2741.8,4049.2,0.8234979573503306,-0.2801630234714981,0.30612948218433994,0.5140948431128801,0.5302133614420238,0.2755493321905811,4220]
["Q4KMQ1","Taperin [OS=Homo sapiens]",12,4,4,4,711,75.5,7.25,13.69,"cell organization and biogenesis;developmental processes;other biological processes","other cell component","other molecular function","TPRN","ENSG00000176058","","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea","",276.3,285.4,297,283.9,319.4,286.7,0.9648314606741573,-0.05165114430505898,0.4631540646223096,0.3342745202441606,0.6223925461159149,0.20593561717535874,5439]
["Q504Q3","PAN2-PAN3 deadenylation complex catalytic subunit PAN2 [OS=Homo sapiens]",7,6,10,6,1202,135.3,5.99,31.96,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PAN2","ENSG00000135473","RNA degradation","Deadenylation of mRNA","Ectoderm differentiation; Ectoderm differentiation",451.3,465.7,447.4,459.6,526,485.4,0.9275322909585316,-0.10853058652878836,0.1520011479432344,0.8181531321635849,0.3909135785774456,0.4079192438710628,2842]
["Q53EZ4-1","Centrosomal protein of 55 kDa [OS=Homo sapiens]",21,9,13,9,464,54.1,7.01,32.64,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cell component","other molecular function","CEP55","ENSG00000138180","","","",845.5,1111.5,815.4,978.3,1000.4,1511.2,0.7944067165248289,-0.3320502743170227,0.2933325404996598,0.5326397564004761,0.5219005692580364,0.2824122294417437,4108]
["Q53FT3","Protein Hikeshi [OS=Homo sapiens]",15,3,8,3,197,21.6,5.45,23.91,"cell organization and biogenesis;stress response;transport;developmental processes","cytosol;nucleus","other molecular function","HIKESHI","ENSG00000149196","","Regulation of HSF1-mediated heat shock response","",818.7,849.9,859.5,712.9,786.5,662.9,1.1691717153031491,0.22548683288346855,0.03249703579153945,1.488156251269987,0.1868771318649582,0.7284438399400224,1271]
["Q53H47","Histone-lysine N-methyltransferase SETMAR [OS=Homo sapiens]",6,4,5,4,684,78,7.14,13.3,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SETMAR","ENSG00000170364","Lysine degradation; Metabolic pathways","","Histone modifications",340.1,351.5,376.1,350.6,392.1,510.5,0.8519789339291415,-0.23111033614011203,0.2761275676446989,0.5588902327004467,0.5110702435844782,0.2915194045530179,3949]
["Q53QZ3","Rho GTPase-activating protein 15 [OS=Homo sapiens]",23,10,14,10,475,54.5,9.39,36.96,"signal transduction;other biological processes","other membranes;cytosol;other cell component","enzyme regulator activity","ARHGAP15","ENSG00000075884","","RAC1 GTPase cycle; RAC3 GTPase cycle","Ectoderm differentiation; Ectoderm differentiation",966.9,1007,1016.9,1023.6,968.2,1111.1,0.9638725063650134,-0.05308576440631552,0.4466026854582099,0.3500786698087468,0.6124238326480406,0.21294791695134613,5330]
["Q53S33","BolA-like protein 3 [OS=Homo sapiens]",7,1,1,1,107,12.1,9.64,2.1,"","cytosol;mitochondrion;nucleus","","BOLA3","ENSG00000163170","","","",66.9,93.3,78.7,69.6,75.2,54.8,1.19689378757515,0.2592951331190713,0.25079451515134216,0.6006819657103541,0.4920958687895731,0.30795028091069276,3725]
["Q567V2-1","Mpv17-like protein 2 [OS=Homo sapiens]",5,1,1,1,206,23.2,9.25,0,"cell organization and biogenesis;other biological processes","other membranes;mitochondrion;translational apparatus;other cell component","","FKSG24; MPV17L2","ENSG00000254858; ENSGGOG00000008883; ENSPPAG00000039781; ENSPTRG00000010696","Peroxisome","","",104.3,114.1,118,160,183.3,496.3,0.40066698427822767,-1.3195244610370103,0.19702545744141065,0.7054776555032356,0.4441884850213666,0.3524327041317587,3242]
["Q56VL3","OCIA domain-containing protein 2 [OS=Homo sapiens]",55,9,40,9,154,16.9,9.03,115.42,"transport;other biological processes","ER/Golgi;other cytoplasmic organelle","","OCIAD2","ENSG00000145247","","","",3972.2,3851,4065.7,4296.2,4016.7,3990,0.9663493972965724,-0.04938318469941658,0.29989236729949903,0.5230345875312131,0.5263960885187412,0.27868734648573873,4164]
["Q5BKT4","Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase [OS=Homo sapiens]",1,1,1,1,473,55.6,9.29,1.85,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","ALG10","ENSG00000139133","N-Glycan biosynthesis; Metabolic pathways","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein","",71.6,65.9,68.8,64.5,69.9,65.4,1.0325325325325323,0.046187238094066024,0.40775496383210524,0.38960074334281675,0.5855169018956498,0.23246056379560254,5090]
["Q5F1R6","DnaJ homolog subfamily C member 21 [OS=Homo sapiens]",23,10,15,10,531,62,5.47,39.69,"other biological processes","cytosol;translational apparatus;nucleus","other molecular function","DNAJC21","ENSG00000168724","","","",1335.8,1336.2,1241.5,1381.4,1536.1,1555.5,0.8749161636485581,-0.19278331346599017,0.042429544968100134,1.3723316257611444,0.21461421741996115,0.668341510969738,1445]
["Q5GJ75","Tumor necrosis factor alpha-induced protein 8-like protein 3 [OS=Homo sapiens]",10,2,2,2,292,32.6,8.59,4.37,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","transporter activity;other molecular function","TNFAIP8L3","ENSG00000183578","","PI Metabolism","",57.4,53.4,56.9,53.8,50.9,74,0.9384443200895356,-0.09165694547714417,0.6450748885128975,0.19038986400046035,0.74957907156451,0.1251825475617563,6290]
["Q5HYK3-1","2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial [OS=Homo sapiens]",24,6,13,6,327,37.1,6.95,36.6,"other metabolic processes","other membranes;mitochondrion;other cell component","other molecular function","COQ5","ENSG00000110871","Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways; Biosynthesis of cofactors","Ubiquinol biosynthesis","",753.4,761.1,804.1,724.6,672.4,2468.3,0.5998499469640132,-0.7373264405746506,0.43177107760029715,0.3647464524586707,0.6023696900516458,0.22013688902264394,5239]
["Q5JRA6-1","Transport and Golgi organization protein 1 homolog [OS=Homo sapiens]",40,63,179,63,1907,213.6,4.84,539.69,"cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","MIA3","ENSG00000154305","","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cargo concentration in the ER","Type I collagen synthesis in the context of osteogenesis imperfecta",16732.5,16349.4,16174.5,17858.1,18942.9,17829.9,0.9016216097483293,-0.1494060009576015,0.011165640059231756,1.9521163763789298,0.11088269455560448,0.9551362288324557,736]
["Q5JS54-1","Proteasome assembly chaperone 4 [OS=Homo sapiens]",30,3,5,3,123,13.8,6.52,15.87,"cell organization and biogenesis","other cell component","other molecular function","PSMG4","ENSG00000180822; ENSGGOG00000012606; ENSPTRG00000033938","","","",572.2,561.4,570.2,673.8,575.4,556.4,0.9436198493575542,-0.08372232842050376,0.4055525810851831,0.39195283024511296,0.5840756286013012,0.23353091494639047,5075]
["Q5JTJ3-1","Cytochrome c oxidase assembly factor 6 homolog [OS=Homo sapiens]",11,1,1,1,125,14.1,8.25,2.19,"cell organization and biogenesis;other metabolic processes","plasma membrane;other membranes;mitochondrion;nucleus","other molecular function","COA6","ENSG00000168275; ENSPTRG00000002122","Thermogenesis","Mitochondrial protein import","Mitochondrial complex IV assembly",15.8,17.7,17.5,15.8,17.9,30.8,0.7906976744186046,-0.3388019134517586,0.3951004602733894,0.4032924643856842,0.5767504022644704,0.2390120939006204,5007]
["Q5JTW2-1","Centrosomal protein of 78 kDa [OS=Homo sapiens]",9,5,5,5,689,76.3,8.18,17.8,"cell organization and biogenesis","cytosol;cytoskeleton","","CEP78","ENSG00000148019","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","Ciliopathies",390.1,413.6,439,551.9,547.2,519.7,0.767667407956511,-0.381446696466647,1.9359828751459773E-3,2.713098488588833,0.050356223610113694,1.29794684660994,281]
["Q5JWF2-1","Guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas [OS=Homo sapiens]",17,14,58,1,1037,111,5.03,185.46,"cell adhesion;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","GNAS","ENSG00000087460","","G alpha (i) signalling events; G alpha (z) signalling events; G alpha (s) signalling events; ADORA2B mediated anti-inflammatory cytokines production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Prostacyclin signalling through prostacyclin receptor; Glucagon-type ligand receptors; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation in glucagon signalling; Hedgehog 'off' state","Thyroid stimulating hormone (TSH) signaling pathway; Endothelin pathways; Corticotropin-releasing hormone signaling pathway; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; G protein signaling pathways; Thermogenesis; Hippo signaling regulation pathways; Purinergic signaling; Prostaglandin and leukotriene metabolism in senescence ; Calcium regulation in cardiac cells; Estrogen signaling pathway; Serotonin receptor 4/6/7 and NR3C signaling",6104.3,6141,6219.2,5142.9,5283.6,4193.7,1.262944419364988,0.3367911492830922,0.020372492725312528,1.6909558286034303,0.14772078306479094,0.8305583988289637,1008]
["Q5MNZ9","WD repeat domain phosphoinositide-interacting protein 1 [OS=Homo sapiens]",7,1,4,1,446,48.6,6.6,18.58,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport","other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","WIPI1","ENSG00000070540","Autophagy; Autophagy; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis","XBP1(S) activates chaperone genes; Macroautophagy","Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Alzheimer's disease",33.7,46.9,38.2,41,42.5,145.1,0.5196850393700787,-0.9442905674137125,0.3506598329678341,0.45511397839988676,0.5553570355713758,0.2554277218778446,4615]
["Q5PSV4","Breast cancer metastasis-suppressor 1-like protein [OS=Homo sapiens]",5,2,4,2,323,37.6,5.15,9.87,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","BRMS1L","ENSG00000100916","","","Genotoxicity pathway",441.7,391.5,439.5,420.3,470.5,1098.3,0.639837112261827,-0.644223419840334,0.33628939672163277,0.47328682586966914,0.5480354962404491,0.261191311365807,4485]
["Q5RKV6","Exosome complex component MTR3 [OS=Homo sapiens]",42,12,34,12,272,28.2,6.28,112.9,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cytoplasmic organelle;other cell component","","EXOSC6","ENSG00000223496","RNA degradation","Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease","",3339.3,3291.6,3349.6,3278.4,3511.4,4961.6,0.8493030617628538,-0.23564864395454493,0.32525380628410594,0.48777761240354345,0.543751159682189,0.2645998037972357,4372]
["Q5SRD1","Putative mitochondrial import inner membrane translocase subunit Tim23B [OS=Homo sapiens]",14,2,6,2,257,28,9.39,26.68,"","","","","","","","",600,613.8,610.8,782.6,655.4,874.7,0.7889479828771565,-0.34199791165629817,0.06306465661476143,1.20021396464695,0.2538213519808873,0.5954718469480434,1816]
["Q5SSJ5-1","Heterochromatin protein 1-binding protein 3 [OS=Homo sapiens]",48,24,119,24,553,61.2,9.67,300.56,"cell organization and biogenesis;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HP1BP3","ENSG00000127483; ENSPPAG00000040189; ENSPTRG00000000296","","","",21754.4,21647.4,21329.3,18053.8,18472,15989.1,1.2326235030438981,0.3017322050635606,0.006367134102810731,2.1960560030500287,0.08634022849247427,1.0637868063527947,539]
["Q5SZL2","Centrosomal protein of 85 kDa-like [OS=Homo sapiens]",1,1,3,1,805,91.8,6.33,5.03,"developmental processes","cytoskeleton;other cell component","","CEP85L","ENSG00000111860","","","",683.9,578.3,601,550.5,695.9,240.7,1.2529083451012035,0.32528088001938305,0.41506697590250846,0.38188181914822344,0.5903336304478369,0.22890247494942348,5139]
["Q5T0D9","Tumor protein p63-regulated gene 1-like protein [OS=Homo sapiens]",31,3,10,3,272,30.2,7.34,53.52,"other biological processes","other membranes;ER/Golgi;other cell component","","TPRG1L","ENSG00000158109","","","",368.7,348.8,388.6,391.5,387.6,441.3,0.9063421828908554,-0.14187226276368228,0.14031806672201405,0.8528864075708602,0.3787240582242247,0.421677105699994,2708]
["Q5T3I0","G patch domain-containing protein 4 [OS=Homo sapiens]",36,16,26,16,446,50.4,9.63,81.55,"","","","GPATCH4","","","","",2338.5,2257.2,2257.1,2980.1,3238.9,3530.2,0.702908956632339,-0.5085902566862666,0.003907237504435255,2.408130189048913,0.06931553135902252,1.1591694431980746,412]
["Q5T4S7-1","e3 ubiquitin-protein ligase UBR4 [OS=Homo sapiens]",24,98,284,98,5183,573.5,6.04,848.76,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus","other molecular function","UBR4","ENSG00000127481","Human papillomavirus infection; Viral carcinogenesis","Neutrophil degranulation; Antigen processing: Ubiquitination & Proteasome degradation","",25371.9,25284.5,25559.1,24102.5,23574.9,25234.9,1.0453037416183553,0.06392221776442968,0.09077692821988824,1.0420245173380842,0.30946295166005744,0.5093913364748436,2144]
["Q5T5U3","rho GTPase-activating protein 21 [OS=Homo sapiens]",2,2,2,2,1957,217.2,7.8,7.72,"","","","","","","","",65,78.6,83.3,79.3,75,456.2,0.3716625716625716,-1.4279346862024285,0.3692034539212403,0.43273424477527184,0.5620720776318153,0.25020798886046464,4801]
["Q5T6V5","queuosine salvage protein [OS=Homo sapiens]",11,4,6,4,341,39,5.88,14.13,"RNA metabolism OR transcription;other metabolic processes","","","C9orf64","ENSG00000165118","","","",564.7,572.5,519.4,563.6,486.9,358.5,1.1757274662881474,0.23355368211222624,0.25443937277078793,0.5944156836918008,0.4952589548819411,0.3051676631480151,3755]
["Q5TAQ9-1","DDB1- and CUL4-associated factor 8 [OS=Homo sapiens]",20,12,20,12,597,66.8,5.39,49.73,"protein metabolism;other metabolic processes","cytosol;mitochondrion;nucleus;other cell component","","DCAF8","ENSG00000132716; ENSPPAG00000008803; ENSPTRG00000001546","","Neddylation","",2722.4,2748.9,2759,2433.9,2456.1,2119,1.1742473962048792,0.2317363945439883,0.020453700596403526,1.689228105592975,0.1478695327983317,0.8301212993000032,1011]
["Q5TC12-1","ATP synthase mitochondrial F1 complex assembly factor 1 [OS=Homo sapiens]",14,4,11,4,328,36.4,7.96,31.61,"cell organization and biogenesis","mitochondrion","","ATPAF1","ENSG00000123472","","","7q11.23 copy number variation syndrome",883,897.5,893.7,792,827.2,515.8,1.252552693208431,0.3248712969385955,0.14226592413343053,0.8468991106888467,0.3804689496857826,0.4196807804975343,2733]
["Q5TF39","Sodium-dependent glucose transporter 1 [OS=Homo sapiens]",6,2,2,2,518,56.2,5.43,6.55,"transport","plasma membrane;other membranes","transporter activity","MFSD4B","ENSG00000173214","","Cellular hexose transport","",212.5,217,228.5,206.2,205.9,270.3,0.9642438452520515,-0.052530062695686434,0.7296552760052598,0.13688227287764274,0.8118511816596808,0.09052357286142808,6569]
["Q5TGZ0","MICOS complex subunit Mic10 [OS=Homo sapiens]",10,1,2,1,78,8.8,8.5,5.26,"cell organization and biogenesis","mitochondrion","","MICOS10","ENSG00000173436","","Cristae formation","",420.3,421.8,394.1,350.9,305.7,184,1.4706162265048774,0.5564208085540958,0.05980673505980369,1.2232499057339252,0.2506464601789594,0.6009384244465007,1744]
["Q5VIR6-4","Isoform 4 of Vacuolar protein sorting-associated protein 53 homolog [OS=Homo sapiens]",26,17,47,17,832,94.3,6.7,140.26,"transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","VPS53","ENSG00000141252; ENSG00000283883","","Retrograde transport at the Trans-Golgi-Network","",3877.2,3877.8,3902.3,3855.7,3837.7,3836.5,1.0110495320861412,0.01585367770045266,0.014770778479235084,1.8305966150247743,0.12597388553644018,0.8997194750639996,857]
["Q5VTE6-1","protein angel homolog 2 [OS=Homo sapiens]",11,5,8,5,544,62.3,7.81,15.84,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ANGEL2","ENSG00000174606; ENSPPAG00000031266; ENSPTRG00000001970","","","",564.6,583.9,559,566.8,553.2,427.7,1.1032499838469987,0.14175972619098506,0.3012506038904613,0.5210720738244373,0.5271344658451955,0.27807858720558554,4177]
["Q5VTY9-1","Protein-cysteine N-palmitoyltransferase HHAT [OS=Homo sapiens]",3,1,1,1,493,57.3,7.28,3.27,"protein metabolism;other metabolic processes;signal transduction","other membranes;ER/Golgi","other molecular function","HHAT","ENSG00000054392; ENSG00000280680","Hedgehog signaling pathway","Hedgehog ligand biogenesis; HHAT G278V doesn't palmitoylate Hh-Np","",62.8,64,77.6,51.6,65.1,56.5,1.1801385681293302,0.23895626621089633,0.16725924002436643,0.7766098808501279,0.4092727771470017,0.3879871415702833,2987]
["Q5VW32","BRO1 domain-containing protein BROX [OS=Homo sapiens]",27,10,25,10,411,46.4,7.65,66.72,"","other membranes","","BROX","ENSG00000162819","","","",4360.6,4387.6,4403.5,4128.8,3936.4,2853.4,1.2045225578370855,0.26846141206949947,0.13418052844715073,0.8723105020619559,0.37134626369565493,0.430220941384907,2641]
["Q5VYS8-1","terminal uridylyltransferase 7 [OS=Homo sapiens]",20,22,38,21,1495,171.1,6.83,111.51,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TUT7","ENSG00000083223","","Deadenylation of mRNA","",2880.5,2888.1,2941.1,3878.7,3931.4,3905.8,0.7434085302878993,-0.4277728522978034,2.0968907879079638E-6,5.678424188249037,0.015326174768819307,1.8145662263650646,1]
["Q5VZE5","N-alpha-acetyltransferase 35, NatC auxiliary subunit [OS=Homo sapiens]",10,5,5,5,725,83.6,7.05,14.31,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","","NAA35","ENSG00000135040","","Retrograde transport at the Trans-Golgi-Network","",165.9,180.5,160,170.3,173.1,273.2,0.8212779759974052,-0.28405748467883385,0.3455974340721989,0.46142949065038347,0.5522456592990166,0.25786768903714014,4574]
["Q5W0Z9-1","Probable palmitoyltransferase ZDHHC20 [OS=Homo sapiens]",5,1,2,1,365,42.3,7.71,5.62,"protein metabolism;other metabolic processes;transport","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","ZDHHC20","ENSG00000180776; ENSPPYG00000005201","","","",64,51.3,79.6,64.9,73.8,185.9,0.6004313000616142,-0.7359289092900819,0.33828890461671624,0.4707122462047964,0.5487247234450907,0.2606454717086355,4506]
["Q5XKP0","MICOS complex subunit MIC13 [OS=Homo sapiens]",75,5,22,5,118,13.1,9.42,65.16,"cell organization and biogenesis","other membranes;mitochondrion;nucleus","","MICOS13","ENSG00000174917","","Cristae formation","",2667.5,2585.6,2678.8,2745.9,2400.8,4536.8,0.8191149894149842,-0.2878620996586199,0.4280345029595502,0.3685212220125441,0.5987567812691584,0.2227495549116627,5225]
["Q63ZY3-1","KN motif and ankyrin repeat domain-containing protein 2 [OS=Homo sapiens]",3,2,3,2,851,91.1,5.63,9.86,"developmental processes;other biological processes","mitochondrion;other cell component","","KANK2","ENSG00000197256","","","",157.4,174.9,163.5,179.5,205.8,246.4,0.7848662339718221,-0.34948130079368445,0.087536808602218,1.0578092908473202,0.3036575861763699,0.5176158645714475,2107]
["Q66K14-1","TBC1 domain family member 9B [OS=Homo sapiens]",14,14,25,12,1250,140.4,5.25,84.37,"transport;other biological processes","other membranes","enzyme regulator activity;other molecular function","TBC1D9B","ENSG00000197226; ENSG00000284400","","","",1577,1576.8,1684.4,1432.5,1442.3,1248.5,1.1733805447093348,0.23067097664803443,0.0303089016467637,1.5184298015866065,0.18098673377140187,0.742353257512176,1224]
["Q676U5","Autophagy-related protein 16-1 [OS=Homo sapiens]",12,6,7,6,607,68.2,6.64,17.74,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","ATG16L1","ENSG00000085978; ENSG00000281089","Autophagy; Autophagy; NOD-like receptor signaling pathway; Shigellosis","Macroautophagy","Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; LDLRAD4 and what we know about it; Autophagy; Senescence and autophagy in cancer",422.9,420.1,445.8,404.9,438.9,602,0.8914096002213306,-0.16583959644843563,0.44186683474336885,0.3547085941120097,0.6105112845253843,0.21430630426322253,5290]
["Q68CZ6","HAUS augmin-like complex subunit 3 [OS=Homo sapiens]",4,3,4,3,603,69.6,5.55,2.05,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","non-structural extracellular;cytosol;cytoskeleton;mitochondrion;nucleus","","HAUS3","ENSG00000214367","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",256.6,259,253.2,238.9,259.9,73.6,1.3431167016072676,0.4255846640470827,0.3289257658202541,0.4829021054918847,0.5440412813714047,0.26436814517020507,4419]
["Q68DQ2","very large A-kinase anchor protein [OS=Homo sapiens]",5,13,14,13,2970,330.4,5.2,33.18,"developmental processes;other biological processes","other cell component","other molecular function","CRYBG3","ENSG00000080200","","","",922.2,970.9,998.5,1106.4,1246.4,1336.5,0.7837801208901418,-0.3514791127317605,0.01963203552029139,1.7070346688462585,0.14523334779130542,0.8379336515499137,988]
["Q69YH5-1","cell division cycle-associated protein 2 [OS=Homo sapiens]",23,18,40,17,1023,112.6,8.4,106.03,"cell cycle OR cell proliferation;other biological processes","cytosol;nucleus;other cell component","","CDCA2","ENSG00000184661","","","",3837.1,3840.1,3886.9,2862.2,2915.8,4265.1,1.1514472622994891,0.20344833543701277,0.3315419980832678,{"$f":"-LOG10(AA3651)","v":0.47946144952008796},0.5455291454278713,{"$f":"-LOG10(AC3651)","v":0.2631820418485701},4442]
["Q6BCY4","NADH-cytochrome b5 reductase 2 [OS=Homo sapiens]",4,1,1,1,276,31.4,8.5,2.31,"other metabolic processes;transport","other membranes;ER/Golgi","other molecular function","CYB5R2","ENSG00000166394","Amino sugar and nucleotide sugar metabolism","Erythrocytes take up carbon dioxide and release oxygen","Oxidation by cytochrome P450",68,76.6,82.1,74,60.3,48.6,1.2394751230180425,0.30972931599206927,0.15752441834481196,0.8026521153319749,0.39674223765755706,0.40149156154971893,2902]
["Q6DD87","Zinc finger protein 787 [OS=Homo sapiens]",14,3,5,3,383,40.5,7.84,20.81,"","","","","","","","",605.4,593.3,574.3,617.3,722.8,619.7,0.9046841514440247,-0.1445138968127816,0.15814672761754334,0.8009397901051794,0.39762450366584945,0.4005268599916341,2907]
["Q6DT37","Serine/threonine-protein kinase MRCK gamma [OS=Homo sapiens]",4,5,5,5,1551,172.4,6.28,16.18,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction","cytosol;cytoskeleton;other cell component","kinase activity;other molecular function","CDC42BPG","ENSG00000171219","","","",383.6,349.1,393.2,499.8,468.7,724.4,0.6650717703349281,-0.5884180593573756,0.08162297881845512,1.0881875597610944,0.29172731158146137,0.5350229102204821,2045]
["Q6IA69","glutamine-dependent NAD(+) synthetase [OS=Homo sapiens]",14,8,12,8,706,79.2,6.44,32.21,"other metabolic processes","cytosol;other cell component","other molecular function","NADSYN1","ENSG00000172890","Nicotinate and nicotinamide metabolism; Metabolic pathways; Biosynthesis of cofactors","Nicotinate metabolism","NAD biosynthesis II (from tryptophan); NAD+ biosynthetic pathways",758.2,811.4,788.9,792.5,839.6,724.2,1.000933667190086,0.001346368592648017,0.9850870889674364,0.006525372968317563,0.9902353917291971,0.004261555728209908,7271]
["Q6IAN0","Dehydrogenase/reductase SDR family member 7B [OS=Homo sapiens]",23,6,11,6,325,35.1,9.55,27.45,"other metabolic processes","other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","DHRS7B","ENSG00000109016","","Plasmalogen biosynthesis","",1183.9,1175.1,1118.1,1030.5,1020,1536.2,0.9694426631722753,-0.0447725209525694,0.841805138651571,0.07478842750554192,0.8933866354587386,0.04896054860688906,6887]
["Q6IEG0-1","U11/U12 small nuclear ribonucleoprotein 48 kDa protein [OS=Homo sapiens]",2,1,1,1,339,39.9,6.95,1.64,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","other molecular function","SNRNP48","ENSG00000168566","","mRNA Splicing - Minor Pathway","",105.3,114.8,119.2,111.7,109.8,159.8,0.8898505114083399,-0.16836510101513838,0.4531550178954472,0.3437532065962556,0.6167802655116991,0.20986953041183817,5370]
["Q6JQN1","Acyl-CoA dehydrogenase family member 10 [OS=Homo sapiens]",2,2,2,2,1059,118.8,8.06,3.95,"other metabolic processes","mitochondrion","other molecular function","ACAD10","ENSG00000111271","","Mitochondrial Fatty Acid Beta-Oxidation","",134.7,139.2,127,123.2,133.3,186.3,0.9053748870822041,-0.14341280463078163,0.5212673099989644,0.28293950993241235,0.6644476401783103,0.1775392366589051,5734]
["Q6KCM7-3","Isoform 3 of Calcium-binding mitochondrial carrier protein SCaMC-2 [OS=Homo sapiens]",14,6,14,6,515,56.8,8.46,36.72,"","","","SLC25A25","","","","",1085.6,1079.5,1118.9,1120.5,1208.3,2127.7,0.7369011556153933,-0.4404569787787658,0.29202798795581864,0.5345755237834824,0.5209745091454914,0.2831835258526518,4097]
["Q6NT16","MFS-type transporter SLC18B1 [OS=Homo sapiens]",2,1,1,1,456,48.8,5.22,2.8,"transport","other membranes","transporter activity","SLC18B1","ENSG00000146409","","","",67.9,64,83,71,63,59.7,1.1094475993804855,0.1498415288245301,0.35071992928692536,0.4550395550953306,0.5552116012904781,0.2555414677624988,4617]
["Q6NUK1","Calcium-binding mitochondrial carrier protein SCaMC-1 [OS=Homo sapiens]",32,14,38,14,477,53.3,6.33,111,"stress response;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","SLC25A24","ENSG00000085491; ENSG00000284468","","","",4693.4,4638.2,4678.8,3989.5,4226,3767.7,1.169170171573536,0.22548492800286088,0.007143375680660791,2.1460965090876156,0.08955563096046264,1.047907101962657,583]
["Q6NW29","RWD domain-containing protein 4 [OS=Homo sapiens]",11,2,3,2,188,21.2,5.31,8.35,"","","","RWDD4","ENSG00000182552","","","",297.5,346.3,305.7,378.6,393.2,504.5,0.7439473478022408,-0.4267275753720306,0.062524670640413,1.2039485873132205,0.2536031174865586,0.5958454120722918,1802]
["Q6NXR4","TELO2-interacting protein 2 [OS=Homo sapiens]",24,10,19,10,508,56.9,7.09,61.94,"","cytosol;cytoskeleton;nucleus","","TTI2","ENSG00000129696","","","",1508.7,1463.8,1547.2,1596.3,1613.9,1698.2,0.9208092250020373,-0.11902580790068476,0.030779498558274613,1.5117384597205323,0.18230741893227645,0.7391956575337822,1234]
["Q6P0N0","Mis18-binding protein 1 [OS=Homo sapiens]",3,3,3,3,1132,129,9.25,5.18,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","nucleic acid binding activity","MIS18BP1","ENSG00000129534","","Deposition of new CENPA-containing nucleosomes at the centromere","",147.3,159.9,167.5,202.9,206.1,571.1,0.4843383328231814,-1.045912905729787,0.24055935966590344,0.6187777409348703,0.483433698047316,0.3156630801056092,3637]
["Q6P1L8","39S ribosomal protein L14, mitochondrial [OS=Homo sapiens]",13,1,1,1,145,15.9,10.24,5.95,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL14","ENSG00000180992","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",38,37.7,33.9,34.3,45.7,52.2,0.8290468986384266,-0.270474378547165,0.23513075196150857,0.6286905672434215,0.4805846381674122,0.3182301154833286,3576]
["Q6P1X5","Transcription initiation factor TFIID subunit 2 [OS=Homo sapiens]",6,6,9,6,1199,136.9,8.19,23.55,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","TAF2","ENSG00000064313","Basal transcription factors","Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation","",498,580.3,534.1,547,540.5,737.8,0.8833616391826002,-0.17892391155012716,0.3615551209791233,0.44182548284473544,0.5590451405196556,0.2525531232636764,4727]
["Q6P1X6","UPF0598 protein C8orf82 [OS=Homo sapiens]",24,4,5,4,216,23.9,9.14,16.32,"","","","C8orf82","ENSG00000213563","","","",273.2,304,273,283.5,230.3,341.8,0.9936886395511924,-0.00913422352586926,0.960089672561715,0.01768820187712765,0.974353709629766,0.011283357028421209,7202]
["Q6P3X3","tetratricopeptide repeat protein 27 [OS=Homo sapiens]",25,16,26,16,843,96.6,5.59,62.23,"","","","TTC27","ENSG00000018699","","","",2171.6,2169.4,2179.1,2135.3,2182.2,1707.7,1.0821383522538672,0.11388496067164999,0.33596553363471415,0.47370527415787317,0.547996448412436,0.26122225618694345,4481]
["Q6P4E1","Protein CASC4 [OS=Homo sapiens]",32,16,37,16,433,48.8,5.82,88.85,"","","","","","","","",3720.4,3952,3817,4092.6,4348.4,5297.2,0.8363104336812681,-0.2578895329634413,0.11450755243021364,0.9411658681660351,0.3454130007067402,0.4616613204195683,2423]
["Q6P6C2-2","RNA demethylase ALKBH5 [OS=Homo sapiens]",24,6,10,6,394,44.2,9.09,30.01,"RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes","cytosol;ER/Golgi;nucleus","other molecular function","ALKBH5","ENSCSAG00000008183; ENSG00000091542; ENSMFAG00000001517; ENSMMUG00000018352; ENSMNEG00000037007; ENSPANG00000023682; ENSPPAG00000030479; ENSPTRG00000024216; ENSRBIG00000029698; ENSRROG00000033654","","Reversal of alkylation damage by DNA dioxygenases","",928.3,900.3,897.9,1064,1033.6,1287.4,0.8054652880354506,-0.31210567834308567,0.05282154196825759,1.277188925004692,0.23584157009529305,0.6273796425326604,1637]
["Q6PD62","RNA polymerase-associated protein CTR9 homolog [OS=Homo sapiens]",14,15,24,15,1173,133.4,6.77,58.56,"cell-cell signaling;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","nucleus;other cell component","other molecular function","CTR9","ENSG00000198730","","E3 ubiquitin ligases ubiquitinate target proteins; RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex","Endoderm differentiation",2139.6,2111.1,2140.4,2809.9,2564.6,3508.2,0.7194997016672858,-0.47493400611944936,0.04253574907594116,1.3712459146474127,0.21485403593369312,0.6678564838824772,1447]
["Q6PGP7","Tetratricopeptide repeat protein 37 [OS=Homo sapiens]",26,38,67,38,1564,175.4,7.53,178.13,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","","TTC37","ENSG00000198677","RNA degradation","mRNA decay by 3' to 5' exoribonuclease","",6277.9,6236.8,6372.4,6128.1,5979.8,6596.4,1.0097731537667807,0.014031226943737934,0.7646135522983137,0.11655800864995645,0.8400060805273373,0.07571757021203275,6653]
["Q6PII5-1","Hydroxyacylglutathione hydrolase-like protein [OS=Homo sapiens]",2,1,1,1,290,31.5,8.21,2.02,"","","other molecular function","HAGHL","ENSG00000103253","","","Orexin receptor pathway",207.8,189.7,215.3,201.9,185.8,367.2,0.8117631474367465,-0.30086924908318524,0.46329211479312415,0.3341450914026663,0.6223492128327411,0.20596585542459786,5441]
["Q6PJG6-1","BRCA1-associated ATM activator 1 [OS=Homo sapiens]",23,12,25,12,821,88.1,5.27,67.16,"cell cycle OR cell proliferation;other metabolic processes;stress response;other biological processes","nucleus;other cell component","","BRAT1","ENSG00000106009","","","",1289,1247.2,1302.2,1502.1,1409,1604.8,0.849974534422817,-0.23450847671027975,0.01857753193757156,1.7310119834042865,0.14218134128974924,0.84715739310406,955]
["Q6PJI9-1","GATOR complex protein WDR59 [OS=Homo sapiens]",4,3,3,3,974,109.7,7.91,9.14,"stress response;other biological processes","other membranes;other cytoplasmic organelle;other cell component","","WDR59","ENSG00000103091","mTOR signaling pathway","Amino acids regulate mTORC1","",264,273.1,266.1,248.9,250.8,341,0.9553943142619246,-0.06583180381246626,0.7030391752267233,0.15302047425362814,0.7909055459030507,0.10187537913502387,6497]
["Q6Q0C0-1","E3 ubiquitin-protein ligase TRAF7 [OS=Homo sapiens]",2,1,1,1,670,74.6,7.15,3.82,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","TRAF7","ENSG00000131653","","Antigen processing: Ubiquitination & Proteasome degradation","",46.6,41.6,40.7,42.5,57.8,45.8,0.8822724161533197,-0.18070391444184722,0.3152601040897185,0.5013309853890171,0.5372432037285504,0.26982906974411736,4289]
["Q6QNY1","biogenesis of lysosome-related organelles complex 1 subunit 2 [OS=Homo sapiens]",21,1,3,1,142,16,4.86,11.69,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","BLOC1S2","ENSG00000196072","","","Genotoxicity pathway",62.6,116.2,62.2,83.3,114.1,26.1,1.0782997762863535,0.10875831504664396,0.8616858732846624,0.064651026939316,0.909598793737377,0.04115012425869925,6924]
["Q6SZW1","Sterile alpha and TIR motif-containing protein 1 [OS=Homo sapiens]",8,4,6,4,724,79.3,6.55,17.3,"other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;other cell component","other molecular function","SARM1","ENSG00000004139","","","Regulation of toll-like receptor signaling pathway",339.5,321.8,309.4,316.3,305.4,528.7,0.8437934631432544,-0.2450381838261158,0.4591720515742111,0.33802455400835746,0.6202344344771592,0.2074441260569663,5411]
["Q6UW02","Cytochrome P450 20A1 [OS=Homo sapiens]",35,13,34,13,462,52.4,6.21,71.7,"","other membranes","other molecular function","CYP20A1","ENSG00000119004","","","Oxidation by cytochrome P450; Metapathway biotransformation Phase I and II",2927.1,3124.1,3203.8,2653.4,2775.9,2638.3,1.1471813178640486,0.19809343469259294,0.01312614005502868,1.8818629661615567,0.11947566334022991,0.9227205495562646,803]
["Q6UWI2","Prostate androgen-regulated mucin-like protein 1 [OS=Homo sapiens]",7,1,3,1,310,32.3,4.68,13.41,"other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","","PARM1","ENSG00000169116","","","",80.7,81.8,87,123.1,111.3,254.9,0.5099121193541795,-0.9716794672084176,0.1577305230974444,0.8020842563851457,0.3969877387462883,0.4012229065292288,2904]
["Q6UWP7-1","Lysocardiolipin acyltransferase 1 [OS=Homo sapiens]",9,3,5,3,414,48.9,8.62,18.6,"other metabolic processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","LCLAT1","ENSG00000172954","Glycerolipid metabolism; Glycerophospholipid metabolism; Metabolic pathways","Synthesis of PA; Acyl chain remodeling of CL","",344.4,351.9,356.4,327,368.6,399,0.9617211766855471,-0.056309408084165576,0.5452875431090705,0.2633744234956217,0.6819826578686168,0.16622666887390783,5844]
["Q6UXV4","MICOS complex subunit MIC27 [OS=Homo sapiens]",47,8,19,8,268,29.1,9.52,61.94,"cell organization and biogenesis","non-structural extracellular;other membranes;mitochondrion;other cell component","","APOOL","ENSG00000155008","","Platelet degranulation ; Cristae formation","",2099.5,1995.7,2070.5,1902.9,1916.6,1422.9,{"$f":"AVERAGE(S3842:U3842)/AVERAGE(V3842:X3842)","v":1.176121623683809},{"$f":"LOG(Y3842,2)","v":0.23403725814420845},{"$f":"TTEST(V3842:X3842,S3842:U3842,2,2)","v":0.13601771350451536},0.866404530039157,{"$f":"AA3842*7309/AE3842","v":0.37332086669339193},0.4279177345941253,2663]
["Q6V1X1","Dipeptidyl peptidase 8 [OS=Homo sapiens]",9,6,11,5,898,103.3,5.8,24.15,"protein metabolism;other biological processes","cytosol;other cell component","other molecular function","DPP8","ENSG00000074603","","","",410.2,379.8,417.9,426.3,409.7,484.3,0.9148678330682423,-0.1283647562441865,0.21465259630003172,{"$f":"-LOG10(AA3843)","v":0.6682638542054695},0.4604918774161819,{"$f":"-LOG10(AC3843)","v":0.33677802588937394},3407]
["Q6Y1H2","Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 [OS=Homo sapiens]",9,2,10,2,254,28.4,9.55,22.85,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","HACD2","ENSG00000206527","Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism","Synthesis of very long-chain fatty acyl-CoAs","",1145.5,1040.6,1172,933.8,927,1353.2,1.044835096453018,0.06327526354781629,0.7595234391752879,0.11945881910545474,0.836299610866553,0.07763810529406692,6638]
["Q6YHK3-1","CD109 antigen [OS=Homo sapiens]",2,2,2,2,1445,161.6,5.85,5.29,"developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol","enzyme regulator activity;other molecular function","CD109","ENSG00000156535","","Platelet degranulation ; Post-translational modification: synthesis of GPI-anchored proteins","",32.2,37.5,46.1,36.7,25.6,114.5,0.6549773755656109,-0.610483021402195,0.5116122483917533,0.291059066724121,0.6576457832387135,0.18200796019457144,5686]
["Q6ZMS4","Zinc finger protein 852 [OS=Homo sapiens]",18,7,10,3,543,62,8.12,25.13,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF852","ENSG00000178917; ENSG00000281626","","","",1214.3,1259.7,1193.8,1531.1,1638.5,658.2,0.9582005329432051,-0.061600479001797395,0.8721763472315829,0.05939569524352806,0.9173603283804345,0.037460045039005976,6949]
["Q6ZQN7","Solute carrier organic anion transporter family member 4C1 [OS=Homo sapiens]",5,2,2,2,724,78.9,7.53,6.93,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle","transporter activity","SLCO4C1","ENSG00000173930","","Neutrophil degranulation; Transport of organic anions","",87.1,93.8,114.2,117.3,143.8,202.2,0.636952298726527,-0.6507427616012644,0.10063764517654013,0.99723953385031,0.3272066497310195,0.48517787886336045,2248]
["Q6ZSR9","Uncharacterized protein FLJ45252 [OS=Homo sapiens]",15,4,6,4,355,38,5.26,18.58,"","","","","","","","",303,320.5,321,401.7,378.9,961.2,0.5422551383626133,-0.8829562760720862,0.23547216989208186,0.6280604141253697,0.4804762952934747,0.3183280337544095,3582]
["Q6ZT07","TBC1 domain family member 9 [OS=Homo sapiens]",2,3,3,1,1266,143.1,5.31,4.78,"transport;other biological processes","","enzyme regulator activity;other molecular function","TBC1D9","ENSG00000109436","","","",45.2,51.2,43,68.7,77.2,94.5,0.5798668885191347,-0.7862063348427626,0.013470045559395922,1.8706309353712396,0.12139650184170751,0.9157938276984227,811]
["Q6ZVF9","G protein-regulated inducer of neurite outgrowth 3 [OS=Homo sapiens]",23,13,20,13,776,82.4,7.56,69.33,"cell organization and biogenesis;developmental processes","plasma membrane;other membranes","","GPRIN3","ENSG00000185477","","","",1493.5,1535.7,1558,2739.6,2930.8,3050.3,0.5260128200717832,-0.9268301333382325,1.1799696938947977E-4,3.9281291468830934,0.015971108319772363,1.7966649448220888,54]
["Q6ZVK8-1","8-oxo-dGDP phosphatase NUDT18 [OS=Homo sapiens]",24,6,8,6,323,35.5,6.23,28.93,"other metabolic processes","cytosol","other molecular function","NUDT18","ENSG00000275074; ENSPTRG00000020049","","","",335.4,337.2,371.4,372.8,349.9,1518.9,0.4657387580299785,-1.1024071489735716,0.3595628931376769,0.4442251337827137,0.559039605603761,0.25255742308699336,4701]
["Q70CQ3","ubiquitin carboxyl-terminal hydrolase 30 [OS=Homo sapiens]",2,1,1,1,517,58.5,8.27,2.23,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle","other molecular function","USP30","ENSG00000135093","Mitophagy","Ub-specific processing proteases; Pexophagy","",105.7,101,127.6,124.6,114.4,139.7,0.8827567995775019,-0.17991206626701625,0.2499976238452182,0.6020641191512186,0.4918526602112247,0.3081649753638398,3715]
["Q70IA6-1","MOB kinase activator 2 [OS=Homo sapiens]",8,2,5,2,237,26.9,6.79,14.96,"other metabolic processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","MOB2","ENSCATG00000043655; ENSCSAG00000009929; ENSG00000182208","","","",654.9,655.8,669.8,687.7,671.8,722.1,0.9514315910837816,-0.07182816592581354,0.0969843605782114,1.013298293179034,0.3204605295959074,0.4942254539277216,2212]
["Q71RC2","La-related protein 4 [OS=Homo sapiens]",8,5,8,5,724,80.5,6.61,23.37,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity","LARP4","ENSG00000161813","","","",684.5,709,728.5,1382.8,1445.9,1287.4,0.5155365515900974,-0.9558533764533469,1.550306832716485E-4,3.8095823388826444,0.01691222782138028,1.7717991796994976,67]
["Q76I76","Protein phosphatase Slingshot homolog 2 [OS=Homo sapiens]",3,2,2,2,1423,158.1,5.41,7.71,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SSH2","ENSG00000141298","Axon guidance; Regulation of actin cytoskeleton","","Regulation of actin cytoskeleton",84.2,83,98,90,90.1,236.6,0.636429085673146,-0.6519283245899613,0.36171527262113884,0.4416331537347726,0.559056233366019,0.2525445058662259,4729]
["Q7L014","probable ATP-dependent RNA helicase DDX46 [OS=Homo sapiens]",46,46,192,45,1031,117.3,9.29,604.08,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus","other molecular function","DDX46","ENSG00000145833","Spliceosome","mRNA Splicing - Major Pathway","",23258.9,23575.8,23625.1,22540.3,22738.4,19559.7,1.0866986230381994,0.1199518894599074,0.14433434174020546,0.8406303241121847,0.38194775661808894,0.4179960364708243,2762]
["Q7L0Y3","Mitochondrial ribonuclease P protein 1 [OS=Homo sapiens]",38,16,56,16,403,47.3,9.36,174.21,"RNA metabolism OR transcription;other metabolic processes;other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","TRMT10C","ENSG00000174173","","tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion","",7893,7881.6,7716.7,6857,7254.7,5249.9,1.213293322865879,0.2789283750972718,0.08895743897142334,1.050817728646337,0.3061157822232266,0.5141142791717954,2124]
["Q7L2J0-1","7SK snRNA methylphosphate capping enzyme [OS=Homo sapiens]",30,13,34,13,689,74.3,9.57,115.51,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MEPCE","ENSG00000146834","","","IL-18 signaling pathway",2137.3,2089.9,2057.3,2596.3,2620.8,3753.8,0.70054286637907,-0.5134547626889856,0.07929510465026784,1.1007536233885782,0.2883422487008993,0.5400917189250941,2010]
["Q7L2Z9","Centromere protein Q [OS=Homo sapiens]",15,3,5,3,268,30.6,9.42,19.29,"cell cycle OR cell proliferation;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","","CENPQ","ENSG00000031691","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Deposition of new CENPA-containing nucleosomes at the centromere","",273.5,312,293.3,290.6,318.1,302.2,0.9647601273465801,-0.0517578116834114,0.4777696958272871,0.3207814003215273,0.6334153286416908,0.1983114309168234,5513]
["Q7L5D6","Golgi to ER traffic protein 4 homolog [OS=Homo sapiens]",20,7,23,7,327,36.5,5.41,65.88,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","GET4","ENSG00000239857","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",1783,1814.5,1799,1651.8,1477.8,1927.7,1.0670713621893104,0.09365666204232073,0.43771144357542113,0.3588120989964553,0.6069499034514804,0.2168471533274397,5271]
["Q7L8L6","FAST kinase domain-containing protein 5, mitochondrial [OS=Homo sapiens]",7,4,8,4,764,86.5,8.13,30.2,"RNA metabolism OR transcription;other metabolic processes;other biological processes","mitochondrion;other cell component","nucleic acid binding activity","FASTKD5","ENSG00000215251","","","",481.3,513.6,476.9,470,491.7,657.8,0.9087990120407534,-0.13796682840379063,0.46097954319840734,0.33631834678643446,0.6210690287994763,0.20686012742302862,5425]
["Q7LBC6-1","Lysine-specific demethylase 3B [OS=Homo sapiens]",14,15,21,15,1761,191.5,7.18,59.58,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KDM3B","ENSG00000120733","Thermogenesis","HDMs demethylate histones","Thermogenesis",1108.3,1144.3,1165.8,1460.1,1442.7,1951.7,0.7041713873725408,-0.5060014875874579,0.046171976237859166,1.3356215365203508,0.22187440783860132,0.6538927886893762,1521]
["Q7Z2E3-4","Isoform 4 of Aprataxin [OS=Homo sapiens]",33,7,22,7,254,29.1,8.59,61.07,"","","","APTX","","","","",1710.6,1656.1,1750.1,1682.1,1633.9,1614.5,1.0377852144812898,0.0535078867915032,0.14056160525318315,0.8521332917189464,0.3789615539636723,0.42140484741545897,2711]
["Q7Z2Z1","Treslin [OS=Homo sapiens]",0,1,2,1,1910,210.7,8.78,0,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","TICRR","ENSG00000140534","","","",79.2,73.3,81.1,88.5,92.2,69.6,0.9332800639232921,-0.09961801680831456,0.4927634559303448,0.30736150757311004,0.6430294767710927,0.19176911835787783,5601]
["Q7Z392","trafficking protein particle complex subunit 11 [OS=Homo sapiens]",8,8,9,8,1133,128.8,7.14,27.94,"cell organization and biogenesis;transport;other biological processes","cytosol;ER/Golgi;other cell component","","TRAPPC11","ENSG00000168538","","RAB GEFs exchange GTP for GDP on RABs","Genes related to primary cilium development (based on CRISPR)",592.4,573.6,609.6,610.9,579.4,871.1,0.861356359755506,-0.21531786297139083,0.3636309990881022,0.4393391008102189,0.5598860274562752,0.25190037064460596,4747]
["Q7Z3K3-1","Pogo transposable element with ZNF domain [OS=Homo sapiens]",11,13,34,13,1410,155.2,7.4,119.03,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","POGZ","ENSG00000143442; ENSPTRG00000001289","","","",2746.7,2910.6,2861.6,2664,2700.4,2824.5,1.040298452783646,0.05699748469391621,0.1845912958255491,0.7337887814469263,0.42831040672664705,0.3682413733525539,3150]
["Q7Z3K6-1","Mesoderm induction early response protein 3 [OS=Homo sapiens]",5,2,2,2,550,61.4,4.51,6.44,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","MIER3","ENSG00000155545; ENSGGOG00000015237","","","",21.3,19.9,14.8,33.8,30,25,0.6306306306306307,-0.6651328494051393,0.027499822003995592,1.5606701171854716,0.17267714693058744,0.7627651356153683,1164]
["Q7Z434","Mitochondrial antiviral-signaling protein [OS=Homo sapiens]",40,11,31,11,540,56.5,5.52,126.96,"stress response;signal transduction;other biological processes","other membranes;mitochondrion;other cytoplasmic organelle","other molecular function","MAVS","ENSG00000088888","NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; Hepatitis C; Hepatitis B; Measles; Influenza A; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease","Ovarian tumor domain proteases; TRAF6 mediated NF-kB activation; Negative regulators of DDX58/IFIH1 signaling; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10","Novel intracellular components of RIG-I-like receptor (RLR) pathway; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation",1219.5,1233,1295.4,1411.2,1440.1,2001.7,0.7722851844220069,-0.37279440001556186,0.12985188820010274,0.8865517308331138,0.364893291370454,0.4378341211450135,2601]
["Q7Z4G4","tRNA (guanine(10)-N2)-methyltransferase homolog [OS=Homo sapiens]",3,2,2,2,463,53.4,7.78,4.86,"RNA metabolism OR transcription;other metabolic processes","other cell component","nucleic acid binding activity;other molecular function","TRMT11","ENSG00000066651","","tRNA modification in the nucleus and cytosol","",328.5,332.9,338.2,352.9,323.1,356.1,0.9685108032167427,-0.0461599534823804,0.3755529500672163,0.42532882217297263,0.5651464920817961,0.24783896376203585,4857]
["Q7Z4H8","KDEL motif-containing protein 2 [OS=Homo sapiens]",2,1,1,1,507,58.5,8.24,0,"protein metabolism;other metabolic processes","ER/Golgi;other cell component","other molecular function","POGLUT3","ENSG00000178202","","","",207.4,197.5,189,197.2,201.5,103.9,1.1816553919617987,0.2408093614078942,0.3991919492327933,0.3988182259994708,0.5793673464937423,0.23704598555132275,5036]
["Q7Z5D8","NANOG neighbor homeobox [OS=Homo sapiens]",4,1,1,1,188,22.7,9.72,2.13,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NANOGNB","ENSG00000205857","","","Pre-implantation embryo",87.2,80.2,70.5,69,80.4,135.7,0.8344440547176428,-0.26111276751281826,0.4984423365134683,0.30238507683583166,0.6482411098891352,0.1882634305209198,5620]
["Q7Z5U6","WD repeat-containing protein 53 [OS=Homo sapiens]",13,2,2,2,358,39,6.52,11.19,"","","","WDR53","ENSG00000185798","","","3q29 copy number variation syndrome",74.4,74.2,79.8,83.5,87.3,141.8,0.7306461932181703,-0.45275512763682146,0.21213218172449477,0.6733934414072247,0.4573669959363812,0.3397351777263339,3390]
["Q7Z5W3","Pre-miRNA 5'-monophosphate methyltransferase [OS=Homo sapiens]",3,1,1,1,292,33.2,6.7,2.56,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","BCDIN3D","ENSG00000186666","","MicroRNA (miRNA) biogenesis","",70.1,78.2,71,102.2,111.6,105.9,0.6859555833593994,-0.5438129321069268,8.6946076319655073E-4,3.0607500119496134,0.036313649818306225,1.4399300987519348,175]
["Q7Z6K3","Protein prenyltransferase alpha subunit repeat-containing protein 1 [OS=Homo sapiens]",4,1,1,1,402,46.4,6.99,2.39,"protein metabolism;other metabolic processes","other cell component","other molecular function","PTAR1","ENSG00000188647","","","",111.4,109,100.9,116,103.8,96,1.0174160861304624,0.024909809611175258,0.7958575689048258,0.0991646490632043,0.8620217799533746,0.06448176109631897,6748]
["Q7Z6L1-1","Tectonin beta-propeller repeat-containing protein 1 [OS=Homo sapiens]",9,6,7,6,1165,129.6,6.24,25,"cell organization and biogenesis;other metabolic processes","other membranes;nucleus;other cytoplasmic organelle;other cell component","other molecular function","TECPR1","ENSG00000205356","Shigellosis","","",306.8,314.1,309.8,298,373.1,370.7,0.8933576502207718,-0.1626902298417035,0.20867288543005302,0.68053397869272,0.45392563083579096,0.34301529419859106,3360]
["Q7Z7A3","Cytoplasmic tRNA 2-thiolation protein 1 [OS=Homo sapiens]",10,2,3,2,348,36.4,9.2,9.81,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol","nucleic acid binding activity;other molecular function","CTU1","ENSG00000142544","Sulfur relay system","tRNA modification in the nucleus and cytosol","",261.9,255.8,265.6,319.8,318.2,540.9,0.664432945966579,-0.5898044836518426,0.14943647344043645,0.8255433899324385,0.3870415252927533,0.4122424374667946,2822]
["Q7Z7H8","39S ribosomal protein L10, mitochondrial [OS=Homo sapiens]",33,5,16,5,261,29.3,9.58,50.63,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus;other cell component","other molecular function","MRPL10","ENSG00000159111","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1341.9,1275.7,1435.3,1131.5,1042.9,1058.3,1.2537198007857213,0.3262149500646514,0.007053504855108344,2.151595030384676,0.0896592469321511,1.0474049131903336,575]
["Q7Z7L1","Schlafen family member 11 [OS=Homo sapiens]",21,12,30,10,901,102.8,7.77,80.77,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SLFN11","ENSG00000172716","","","",2375.3,2294.6,2315.1,2455.9,2255.5,2785.8,0.931681160966761,-0.10209177326033678,0.33656264408399317,0.47293408909844875,0.5477480217345594,0.2614191822771906,4491]
["Q86TG7-1","Retrotransposon-derived protein PEG10 [OS=Homo sapiens]",22,12,39,4,708,80.1,6.39,131.72,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PEG10","ENSG00000242265","","","",3229.3,3495.4,3059.3,1321.2,1361.4,2135.8,2.0305495600199235,1.0218702398317563,4.890550541357873E-3,2.3106422485214915,0.07770659544953194,1.1095421183190923,460]
["Q86TU7","Histone-lysine N-methyltransferase setd3 [OS=Homo sapiens]",15,8,12,8,594,67.2,5.96,42.46,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","cytoskeletal activity;other molecular function","SETD3","ENSG00000183576","","PKMTs methylate histone lysines","Histone modifications",1069.1,1082.8,1112.4,1100.7,1092,1005.9,1.0205402363534044,0.029333063941601272,0.5413755066827939,0.26650139679811885,0.679765259980165,0.16764103419902646,5821]
["Q86U38","Nucleolar protein 9 [OS=Homo sapiens]",16,9,15,9,636,69.4,7.28,32,"RNA metabolism OR transcription;other metabolic processes;transport","nucleus;other cell component","","NOP9","ENSG00000196943; ENSG00000285326","","","",902.1,989.7,966.6,1059.3,1056.1,1537.4,0.7825229960578187,-0.35379494563943137,0.17755647647735823,0.7506634819256954,0.4203952985335313,0.3763421495238179,3087]
["Q86UD5","Sodium/hydrogen exchanger 9B2 [OS=Homo sapiens]",3,1,1,1,537,57.5,6.71,2.37,"transport;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle","transporter activity;other molecular function","SLC9B2","ENSG00000164038","","Stimuli-sensing channels","",26.4,40.5,28.4,31.7,38.2,54,0.7691686844229217,-0.37862806823065964,0.29678155343873597,0.5275630962795759,0.5240822358259776,0.2806005607963629,4139]
["Q86UF1","Tetraspanin-33 [OS=Homo sapiens]",5,1,2,1,283,31.5,7.17,7.59,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","TSPAN33","ENSG00000158457","","Amyloid fiber formation","",46.2,48.9,47.6,57.5,46.6,26.1,1.0960061443932412,0.13225588631012797,0.6753173956642751,0.17049206303903663,0.770511215252917,0.11322103548286665,6406]
["Q86UV5","Ubiquitin carboxyl-terminal hydrolase 48 [OS=Homo sapiens]",15,11,20,11,1035,119,6.05,67.89,"protein metabolism;other metabolic processes","cytosol;mitochondrion;nucleus","other molecular function","USP48","ENSG00000090686","","Ub-specific processing proteases","",2002.5,2021.8,1955.1,2196.3,2182.8,1684.5,0.9861138597532818,-0.020173860639363193,0.8765565875624197,0.05722004206553737,0.9205103589789836,0.03597131979212652,6960]
["Q86V42","Protein FAM124A [OS=Homo sapiens]",1,1,1,1,546,60.1,6.6,1.79,"","","","FAM124A","ENSG00000150510","","","",296.4,259.3,268.5,282.5,293.6,311.3,0.928780707685373,-0.10659008953972446,0.20565306912118383,0.686864804791089,0.4509805827202918,0.34584215656764616,3333]
["Q86V85","Integral membrane protein GPR180 [OS=Homo sapiens]",5,2,3,2,440,49.4,7.39,6.67,"signal transduction;other biological processes","other membranes","","GPR180","ENSG00000152749","","","",112.8,100.3,106.5,108.7,99,951.6,0.27568360217372556,-1.8589146373550067,0.3780531684374993,0.4224471177944456,0.5663436376531426,0.24691997402273888,4879]
["Q86VQ1","Glucocorticoid-induced transcript 1 protein [OS=Homo sapiens]",20,8,12,8,547,58,9.44,39.59,"","other cell component","","GLCCI1","ENSG00000106415","","","",1103.5,1140.6,1098.2,1477.9,1567,2213.3,0.6356357688942984,-0.6537277836772363,0.051292291503856814,1.2899478982192973,0.23285426000104936,0.632915812367174,1610]
["Q86VX9","Vacuolar fusion protein MON1 homolog A [OS=Homo sapiens]",12,4,4,4,555,62.1,6.3,15.8,"","","","","","","","",126.7,136.1,145.1,130,142.8,140.6,0.9866956942428642,-0.019322881632924234,0.7955644860945954,0.09932461196966638,0.8620875950875312,0.06444860409361647,6745]
["Q86W56","Poly(ADP-ribose) glycohydrolase [OS=Homo sapiens]",17,12,21,12,976,111,6.43,67.22,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","PARG","ENSG00000227345","","POLB-Dependent Long Patch Base Excision Repair","",1121.1,1100.6,1176,1229.4,1247.5,1182.3,0.9285362920857018,-0.10696979550875459,0.04275748744633268,1.36898782311371,0.2155272246518935,0.666497863464712,1450]
["Q86WN1-1","F-BAR and double SH3 domains protein 1 [OS=Homo sapiens]",9,6,7,6,690,76.9,5.34,16.03,"cell-cell signaling;cell organization and biogenesis","cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","FCHSD1","ENSG00000197948","","","",906,889.2,898.3,891.6,933.5,1271.5,0.869824969321191,-0.2012029712787482,0.326788171630862,0.4857336715044151,0.5438284941825979,0.26453804106247764,4392]
["Q86WU2","Probable D-lactate dehydrogenase, mitochondrial [OS=Homo sapiens]",3,1,1,1,507,54.8,6.65,3.44,"other metabolic processes","other membranes;mitochondrion","other molecular function","LDHD","ENSG00000166816","Pyruvate metabolism; Metabolic pathways","Mitochondrial protein import","Clear cell renal cell carcinoma pathways",53.9,49.7,62.3,50.7,55.8,70.2,0.9388794567062817,-0.09098815359575389,0.6301041200733908,0.20058768064627822,0.7400660475038427,0.13072951974677577,6223]
["Q86X95","Corepressor interacting with RBPJ 1 [OS=Homo sapiens]",8,4,5,4,450,52.3,9.86,9.3,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","CIR1","ENSG00000138433","Notch signaling pathway; Epstein-Barr virus infection","","Notch signaling pathway (Netpath)",278.7,221.8,266.3,367,392,259.9,0.7525763077829031,-0.4100902229438807,0.12905067570559997,0.8892397171608315,0.3640414468283405,0.4388491682626833,2591]
["Q86Y07","serine/threonine-protein kinase VRK2 [OS=Homo sapiens]",6,3,5,3,508,58.1,8.84,10.03,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;mitochondrion;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","VRK2","ENSG00000028116","","RAC1 GTPase cycle; RAC3 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOD GTPase cycle","",226.7,218.6,251.5,254.3,270.1,312.7,0.8323975630151713,-0.2646553535419783,0.08006036050939656,1.0965824586115145,0.2888258514132179,0.5393639377518032,2026]
["Q86Y39-1","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [OS=Homo sapiens]",26,2,4,2,141,14.8,8.72,13.78,"cell organization and biogenesis","other membranes;mitochondrion","","NDUFA11","ENSG00000174886; ENSPPAG00000024786; ENSPTRG00000029161","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Nonalcoholic fatty liver disease; Oxidative phosphorylation",222.8,250.1,255.5,321.1,307.5,217.2,0.8611965003546938,-0.2155856380519635,0.31558046724368694,0.5008898851546423,0.5371629331821397,0.26989396337089916,4294]
["Q86YB8","ERO1-like protein beta [OS=Homo sapiens]",11,5,8,3,467,53.5,7.99,22.85,"other biological processes","other membranes;ER/Golgi","other molecular function","ERO1B","ENSG00000086619","Protein processing in endoplasmic reticulum","Insulin processing","",249.9,248.9,260.9,230.3,251.9,367,0.8946066886481395,-0.16067454999954853,0.5223350610771975,0.28205082171938367,0.6652286045327124,0.17702908458236902,5739]
["Q86YS6","Ras-related protein Rab-43 [OS=Homo sapiens]",39,7,20,6,212,23.3,5.64,58.4,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","RAB43","ENSG00000172780","","Retrograde transport at the Trans-Golgi-Network; RAB geranylgeranylation","",1526.8,1555.3,1686.2,1512.7,1567.4,1057.6,1.15240350919593,0.20464595878280675,0.2811941122523178,0.550993776977601,0.515487275257635,0.2877820507560224,3987]
["Q86YV0","RAS protein activator like-3 [OS=Homo sapiens]",38,35,96,33,1011,111.8,8.75,290.2,"signal transduction;other biological processes","other membranes;cytosol;other cell component","enzyme regulator activity;other molecular function","RASAL3","ENSG00000105122","Ras signaling pathway","Regulation of RAS by GAPs","Ras signaling",10625.1,10413.7,10733.5,11074.1,10704.5,15522.9,0.8517700360575313,-0.231464115869689,0.3004587980354985,0.5222150744521215,0.526757820782312,0.2783890076944459,4169]
["Q8IU85-1","calcium/calmodulin-dependent protein kinase type 1D [OS=Homo sapiens]",29,11,29,8,385,42.9,7.21,95.13,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","kinase activity;other molecular function","CAMK1D","ENSCATG00000031901; ENSG00000183049; ENSGGOG00000016547; ENSMMUG00000011956; ENSMNEG00000040028; ENSPPYG00000002093; ENSPTRG00000002296; ENSRBIG00000041279; ENSRROG00000039467","Calcium signaling pathway; Oxytocin signaling pathway; Aldosterone synthesis and secretion; Glioma","","",3609.5,3559.6,3667.6,3671.2,3658.7,3088,1.0402000403152267,0.05686099896155247,0.5133501694951896,0.2895862902488736,0.6589526499543978,0.18114579117583696,5694]
["Q8IUC8-1","Polypeptide N-acetylgalactosaminyltransferase 13 [OS=Homo sapiens]",3,2,2,1,556,64,6.83,4.33,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","GALNT13","ENSG00000144278; ENSGGOG00000034959; ENSMFAG00000043213; ENSMMUG00000055468; ENSPPAG00000035152; ENSPPYG00000012857; ENSPTRG00000012546","Mucin type O-glycan biosynthesis; Other types of O-glycan biosynthesis; Metabolic pathways","O-linked glycosylation of mucins","",125.3,156,103.7,109.7,130.6,110,1.0990579503282902,0.1362674576675634,0.5260981629764897,0.2789332146646667,0.6681583793562403,0.17512058074650433,5755]
["Q8IUR0","Trafficking protein particle complex subunit 5 [OS=Homo sapiens]",32,5,14,5,188,20.8,9.66,29.55,"transport","cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","TRAPPC5","ENSG00000181029","","RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport","",1290.8,1289.2,1264.4,1397.6,1278.5,743.8,1.1241264364455104,0.1688043122263437,0.5207114905828992,0.28340283860683896,0.6642024929616772,0.17769949869025597,5730]
["Q8IV36","protein HID1 [OS=Homo sapiens]",3,2,2,2,788,88.7,6.06,5.21,"","other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","","HID1","ENSG00000167861","","","",137.9,130.9,136.7,181.7,155,280,0.6575320252959298,-0.6048669318733827,0.13809649161197263,0.8598173546792631,0.37592076617948156,0.42490368283086455,2685]
["Q8IV53-1","DENN domain-containing protein 1C [OS=Homo sapiens]",11,5,11,5,801,87,5.67,41.56,"transport","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","DENND1C","ENSG00000205744","","RAB GEFs exchange GTP for GDP on RABs","",624.4,611.3,566.1,622.4,643,821.5,0.8633858833676744,-0.21192259041547334,0.22120438963880285,0.6552062590264985,0.4668734865347993,0.3308007886919864,3463]
["Q8IVH4","methylmalonic aciduria type A protein, mitochondrial [OS=Homo sapiens]",10,4,5,4,418,46.5,9.29,14.05,"other metabolic processes","mitochondrion;other cell component","other molecular function","MMAA","ENSG00000151611","","Cobalamin (Cbl, vitamin B12) transport and metabolism; Propionyl-CoA catabolism; Defective MMAA causes MMA, cblA type; Defective MUT causes MMAM","",422.2,390.6,431.8,393.4,367.8,481.8,1.0012872083668543,1.8558549475265666E-3,0.9891035572380975,0.004758236226256925,0.9931800933992657,2.9719937222781614E-3,7279]
["Q8IW19","Aprataxin and PNK-like factor [OS=Homo sapiens]",5,2,2,2,511,56.9,5.08,6.3,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","APLF","ENSG00000169621","","","",70.9,73.1,72.8,46.5,67.9,49,1.3268053855569155,0.40795677320818813,0.05871517603006628,1.231249632751098,0.24907093534750693,0.6036769483151535,1723]
["Q8IW50","Protein FAM219A [OS=Homo sapiens]",9,1,2,1,185,20.4,4.73,6.09,"","","","FAM219A","ENSG00000164970","","","",199.2,188.4,171.3,178.8,195.6,109.2,1.155707196029777,0.2087759304136705,0.41561058004393325,0.38131340530106506,0.5907619077287258,0.22858751572393388,5142]
["Q8IWD4-1","Coiled-coil domain-containing protein 117 [OS=Homo sapiens]",11,3,3,3,279,30.5,5.07,4.93,"","","","CCDC117; FLJ33814","ENSG00000159873","","","",190.6,188.6,183.8,258.9,274.9,282.1,0.6900355435715162,-0.5352574181941404,2.95623894931713E-4,{"$f":"-LOG10(AA4227)","v":3.5292604653462947},0.021393218297583075,{"$f":"-LOG10(AC4227)","v":1.6697238772449643},101]
["Q8IWJ2","GRIP and coiled-coil domain-containing protein 2 [OS=Homo sapiens]",30,44,73,43,1684,195.8,5.14,202.13,"cell organization and biogenesis;transport;other biological processes","cytosol;ER/Golgi;nucleus","other molecular function","GCC2","ENSG00000135968","Salmonella infection","Signaling by ALK fusions and activated point mutants; Retrograde transport at the Trans-Golgi-Network","Deregulation of Rab and Rab effector genes in bladder cancer",6238.3,6273.9,6290.2,7271.3,7332,7336.7,0.8569917958067458,-0.2226467017579622,2.2980914967218776E-6,5.638632684207188,0.005598916916513401,2.2518959770428775,3]
["Q8IWU5-1","Extracellular sulfatase Sulf-2 [OS=Homo sapiens]",7,5,7,5,870,100.4,9.17,19.82,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","SULF2","ENSG00000196562","","","",479.2,476.1,523.2,518,512.9,668.6,0.8699617534568991,-0.20097611842134763,0.23901460740059294,0.6215755562919708,0.48325249391173825,0.31582589603854744,3615]
["Q8IWY9","Codanin-1 [OS=Homo sapiens]",5,3,5,3,1227,134,6.77,18.73,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","","CDAN1","ENSG00000140326","","","",208,212.9,208.7,201.2,174.2,1192.8,0.401479403137355,-1.3166021189848927,0.4033737679340679,0.3942923480962576,0.5827750286282075,0.23449906562085204,5059]
["Q8IWZ8-1","SURP and G-patch domain-containing protein 1 [OS=Homo sapiens]",9,5,9,5,645,72.4,7.61,25.73,"RNA metabolism OR transcription;other metabolic processes","nucleus","","SUGP1","ENSG00000105705","","mRNA Splicing - Major Pathway","mRNA processing",787.4,715.1,557.8,854.1,739.9,941.6,0.8125492979965296,-0.2994727497757537,0.1512765936518775,0.8202282632141042,0.3900108017642232,0.40892336455905665,2835]
["Q8IXH7","Negative elongation factor C/D [OS=Homo sapiens]",25,11,27,11,590,66.2,5.1,83.75,"other biological processes","nucleus","nucleic acid binding activity","NELFCD","ENSG00000101158","","RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat","Initiation of transcription and translation elongation at the HIV-1 LTR",2332.3,2298.5,2365,2418.7,2348.7,1712.3,1.0796487491704863,0.11056202511736649,0.48808725867511915,0.3115025292812211,0.6394389269862781,0.1942009288076173,5579]
["Q8IXS8","protein FAM126B [OS=Homo sapiens]",3,2,2,2,530,58.6,7.9,3.57,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol","","FAM126B","ENSG00000155744","","","",163.4,155.5,149,157.7,148.1,108.1,1.1304662962068133,0.17691798013002016,0.31681766723430593,0.4991906081165388,0.5377659846297125,0.2694066717200343,4306]
["Q8IXW5","Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 [OS=Homo sapiens]",14,7,8,7,612,69.5,7.78,26.92,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","RPAP2","ENSG00000122484","","RNA polymerase II transcribes snRNA genes","",622.2,648.3,681.4,836.7,786.7,879.1,0.77998001998002,-0.35849092661110643,0.004436133784779006,2.352995364886458,0.07319120052584595,1.1355411292255546,443]
["Q8IY63-1","Angiomotin-like protein 1 [OS=Homo sapiens]",1,1,1,1,956,106.5,7.11,0,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","AMOTL1","ENSG00000166025","Tight junction","Signaling by Hippo","",114.9,115.3,134.1,148.7,150.8,161,0.7910966340933767,-0.33807416123591594,0.012238605723518441,1.912268056134332,0.11527315622834572,0.9382718155085474,776]
["Q8IY95","transmembrane protein 192 [OS=Homo sapiens]",12,3,11,3,271,30.9,7.99,29.51,"","other membranes;nucleus;other cytoplasmic organelle;other cell component","other molecular function","TMEM192","ENSG00000170088","","","",1687,1688.8,1770.2,1533.9,1651.9,1091,1.2032360643471753,0.26691971437808404,0.1691453743300964,0.771739874496651,0.4108619278759304,0.3863041003527587,3009]
["Q8IYD1","eukaryotic peptide chain release factor GTP-binding subunit ERF3B [OS=Homo sapiens]",32,17,60,5,628,68.8,5.43,148.61,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","GSPT2","ENSG00000189369","mRNA surveillance pathway","Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Translation factors",277.5,293.5,280.6,296.8,291.9,319.8,0.9373692900385251,-0.09331056466918412,0.12782566130089507,0.8933819517906553,0.36254472582392006,0.44063840845758706,2577]
["Q8IYS1","Peptidase M20 domain-containing protein 2 [OS=Homo sapiens]",51,17,62,16,436,47.7,5.85,200.63,"protein metabolism;other biological processes","nucleus","other molecular function","PM20D2","ENSG00000146281","","","",7716.9,7414.7,7632.2,7518.8,7594,8671.3,0.9571015930810921,-0.06325602487285747,0.42470936796839154,0.37190815951294887,0.5967321742562426,0.22422054548882983,5202]
["Q8IYU8","calcium uptake protein 2, mitochondrial [OS=Homo sapiens]",12,4,5,4,434,49.6,9.09,13.56,"transport;other biological processes","other membranes;mitochondrion","other molecular function","MICU2","ENSG00000165487","","Processing of SMDT1","",310.3,299.7,310,322.9,277.7,225.7,1.1133970712816168,0.1549681934061588,0.3316335711704832,0.47934151239162587,0.545311534687303,0.2633553158138854,4445]
["Q8IZ81","ELMO domain-containing protein 2 [OS=Homo sapiens]",29,8,34,8,293,34.9,8.05,93.22,"stress response;other biological processes","","enzyme regulator activity","ELMOD2","ENSG00000179387","","","Lung fibrosis",3350.3,3555.4,3573.4,2962.8,2803.5,1942,1.3594566895424411,0.4430301897755801,0.04679798213407299,1.3297728727149898,0.22312227750680982,0.651457065685392,1533]
["Q8IZN3-1","Probable palmitoyltransferase ZDHHC14 [OS=Homo sapiens]",2,1,1,1,488,53.4,8.24,1.87,"protein metabolism;other metabolic processes;transport","other membranes;ER/Golgi","other molecular function","ZDHHC14","ENSG00000175048; ENSGGOG00000012728; ENSPPYG00000017128","","","",30.9,25.2,32.3,34.8,28.9,36.3,0.8839999999999999,-0.17788172527065563,0.28468818964263237,0.5456305492893817,0.5177372426220453,0.2858905935974435,4019]
["Q8IZT6-1","Abnormal spindle-like microcephaly-associated protein [OS=Homo sapiens]",3,8,10,8,3477,409.5,10.45,29.69,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","other molecular function","ASPM","ENSG00000066279","","","",559.2,595.5,586.2,638.8,603.1,725.2,0.8850083879823091,-0.17623696597067304,0.11714071215852974,0.9312921400009088,0.3487500876442745,0.4574856745759231,2455]
["Q8N0X7","Spartin [OS=Homo sapiens]",1,1,1,1,666,72.8,5.91,1.7,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;other cell component","other molecular function","SPART","ENSG00000133104","Endocytosis","","",94.1,82.8,83.7,101.9,97.9,144.9,0.7560197272991005,-0.4035042147991353,0.1442948929212982,0.8407490397682463,0.38212006244991614,0.41780015994949116,2760]
["Q8N0Z8","tRNA pseudouridine synthase-like 1 [OS=Homo sapiens]",10,3,5,3,303,33.2,9.85,13.95,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","PUSL1","ENSG00000169972","","","",323.9,290.6,343.1,293.3,273.7,457.8,0.9344262295081968,-0.09784732339814455,0.7293598969911235,0.13705811954467714,0.8116460851260843,0.09063330177208855,6568]
["Q8N141","Zinc finger protein 82 homolog [OS=Homo sapiens]",1,1,1,1,532,62.5,8.98,2.89,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZFP82","ENSG00000181007","Herpes simplex virus 1 infection","","",138.6,134.9,152.4,221.5,210.4,70.4,0.8478996615568387,-0.23803454512149166,0.6301010595724648,0.2005897900784334,0.7401813957594254,0.130661834967145,6222]
["Q8N1G4","Leucine-rich repeat-containing protein 47 [OS=Homo sapiens]",42,21,77,21,583,63.4,8.28,235.75,"","","other molecular function","LRRC47","ENSG00000130764","","","",7328.1,7226.5,7401.7,7737.4,7529.8,7690.3,0.9563889796362844,-0.06433058875635156,0.014488680238500994,1.8389711722403654,0.1254712841981087,0.9014556569820477,844]
["Q8N1S5-1","zinc transporter zip11 [OS=Homo sapiens]",10,2,4,2,342,35.4,5.6,13.38,"transport","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","transporter activity","SLC39A11","ENSG00000133195","Alzheimer disease; Parkinson disease","","Nuclear receptors meta-pathway; NRF2 pathway; Zinc homeostasis",95.2,95.7,106.1,80.8,81.7,137.4,0.990330110036679,-0.014018591180611885,0.9619679949401382,0.016839376872905727,0.9751767094337683,0.010916679708361821,7210]
["Q8N2K1-1","Ubiquitin-conjugating enzyme E2 J2 [OS=Homo sapiens]",5,1,1,1,259,28.9,8.4,4.48,"protein metabolism;other metabolic processes;stress response","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","UBE2J2","ENSG00000160087","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum; Parkinson disease; Pathways of neurodegeneration","Antigen processing: Ubiquitination & Proteasome degradation; E3 ubiquitin ligases ubiquitinate target proteins","Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway",81,76.2,77.7,128.6,135.8,173.8,{"$f":"AVERAGE(S4354:U4354)/AVERAGE(V4354:X4354)","v":0.5360565951620264},{"$f":"LOG(Y4354,2)","v":-0.8995427709780258},{"$f":"TTEST(V4354:X4354,S4354:U4354,2,2)","v":0.00859462746957331},2.065772942876279,{"$f":"AA4354*7309/AE4354","v":0.09664328026940204},1.0148283376351617,650]
["Q8N3C0","Activating signal cointegrator 1 complex subunit 3 [OS=Homo sapiens]",22,36,65,36,2202,251.3,7.09,177.2,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","cytosol;nucleus","other molecular function","ASCC3","ENSG00000112249","","ALKBH3 mediated reversal of alkylation damage","Mesodermal commitment pathway; VEGFA-VEGFR2 signaling pathway",6792.3,6906.7,6955.9,7283.3,6674.8,6988.6,0.9860694047272363,-0.020238900280236796,0.6218260305182981,0.2063311017302106,0.7342369074407498,0.1341637888663556,6190]
["Q8N3F8","MICAL-like protein 1 [OS=Homo sapiens]",8,6,7,6,863,93.4,7.25,21.62,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;other cytoplasmic organelle","other molecular function","MICALL1","ENSG00000100139","","","",741.2,733.8,741.7,846,838.7,786.6,0.8969772993970784,-0.156856620848371,0.010855743568660262,1.964340424009996,0.1091397933195844,0.9620168729850609,727]
["Q8N3Z6","Zinc finger CCHC domain-containing protein 7 [OS=Homo sapiens]",9,4,4,4,543,63,7.33,7.63,"","cytosol;nucleus","other molecular function","ZCCHC7","ENSG00000147905","RNA degradation","","",115.7,88.1,89.3,96.9,121.3,182.9,0.7307404637247569,-0.4525689981249677,0.2551671736676758,0.5931751967689025,0.49535640699523037,0.30508221542164893,3765]
["Q8N488","RING1 and YY1-binding protein [OS=Homo sapiens]",30,5,8,5,228,24.8,9.63,24.08,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RYBP","ENSG00000163602","","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Transcriptional Regulation by E2F6","",707,697.9,724.8,544,600.8,385.1,1.3920517680894176,0.4772128636127518,0.037134259427464116,1.4302252328436544,0.2004536943540142,0.697985935308807,1354]
["Q8N4Q0","Prostaglandin reductase 3 [OS=Homo sapiens]",11,4,9,4,377,40.1,8.18,24.72,"other metabolic processes;other biological processes","other cytoplasmic organelle","other molecular function","ZADH2","ENSG00000180011","","","",708.1,690.4,685,654.7,688.5,809.7,0.967764410794742,-0.047272209313908256,0.6521972742090157,0.18562102061509259,0.7535425035083301,0.12289224631082366,6326]
["Q8N554","Zinc finger protein 276 [OS=Homo sapiens]",2,1,1,1,614,67.2,8.51,1.62,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF276","ENSG00000158805","","","",88.6,76.7,87.2,85.2,80.4,81.3,1.0226812474686107,0.03235655138373742,0.6675893060004501,0.17549062882651212,0.7651576348686356,0.11624908392979426,6377]
["Q8N584-1","Tetratricopeptide repeat protein 39C [OS=Homo sapiens]",2,1,1,1,583,65.8,6.99,4.74,"cell organization and biogenesis;developmental processes","","","TTC39C","ENSG00000168234","","","",46.2,47.4,64.3,59.5,54.5,193.7,0.5131621709457262,-0.9625132724733082,0.33839256100275894,0.47057919276943067,0.5486493408094866,0.26070513825952657,4508]
["Q8N5G2-1","macoilin [OS=Homo sapiens]",10,7,10,7,664,76.1,9.07,24.67,"developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","cytoskeletal activity","LOC111154705; MACO1","ENSANAG00000024751; ENSCAFG00000012804; ENSCAFG00040000254; ENSCATG00000033846; ENSCCAG00000030283; ENSCPOG00000012618; ENSCSAG00000000952; ENSG00000204178; ENSMMUG00000018014; ENSMNEG00000031369; ENSPANG00000000594; ENSPPAG00000042632; ENSPPYG00000001709; ENSPTRG00000029594","","RHOC GTPase cycle; RHOA GTPase cycle","",1260.6,1225.8,1236.9,1268.5,1476.8,1496,0.8778676349232546,-0.18792466860709728,0.07875893371563149,1.1037001722260487,0.2878245232637753,0.5408722060060569,2000]
["Q8N5U6-1","RING finger protein 10 [OS=Homo sapiens]",5,3,3,3,811,89.9,6.92,6.95,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RNF10","ENSG00000022840","","","",126.9,152.7,150.9,172.1,184.4,265.3,0.6923448054036668,-0.5304373790568576,0.10387928933316282,0.9834710301607711,0.33286002881897725,0.4777383535534466,2281]
["Q8N5X7","Eukaryotic translation initiation factor 4E type 3 [OS=Homo sapiens]",15,3,5,3,224,24.4,6.42,13.8,"protein metabolism;other metabolic processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity","EIF4E3","ENSG00000163412","","ISG15 antiviral mechanism","",754,783.3,772.5,743.5,754,869.7,0.9757519432240623,-0.03541366407230126,0.6674399802545693,0.17558778227232827,0.7651064641908167,0.11627812877641118,6376]
["Q8N6H7","ADP-ribosylation factor GTPase-activating protein 2 [OS=Homo sapiens]",28,14,36,14,521,56.7,7.99,94.25,"cell organization and biogenesis;transport","plasma membrane;other membranes;cytosol;ER/Golgi","enzyme regulator activity;other molecular function","ARFGAP2","ENSG00000149182","Endocytosis","COPI-dependent Golgi-to-ER retrograde traffic; CDC42 GTPase cycle; COPI-mediated anterograde transport","IL-18 signaling pathway",4921.7,4763.9,5018.4,6443.8,6159.8,5531.6,0.8107988883497287,-0.3025839840961581,0.014954355508276788,1.8252322991308496,0.12724258953433648,0.895367501078119,859]
["Q8N6M3","fat storage-inducing transmembrane protein 2 [OS=Homo sapiens]",5,1,2,1,262,29.8,8.65,6.54,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","FITM2","ENSG00000197296","","Lipid particle organization","",212.5,222.4,243.7,243.9,233.8,112.4,1.1499745805795625,0.20160197171128988,0.5325639121546826,0.2736282657661826,0.6725137584551788,0.17229882632920948,5788]
["Q8N806","Putative E3 ubiquitin-protein ligase UBR7 [OS=Homo sapiens]",21,6,15,6,425,48,4.81,48.09,"protein metabolism;other metabolic processes","other cell component","other molecular function","UBR7","ENSG00000012963; ENSG00000278787","","","",1159.5,1188.1,1113.5,1509,1541.6,1218.8,0.8106759732046659,-0.3028027097449812,0.06203842818935899,1.207339214039211,0.2537430731035394,0.5956058046608822,1787]
["Q8N8Q9","Magnesium transporter NIPA2 [OS=Homo sapiens]",4,1,1,1,360,39.2,8.22,5.24,"transport","plasma membrane;other membranes;other cytoplasmic organelle","transporter activity","NIPA2","ENSG00000140157","","Miscellaneous transport and binding events","Prader-Willi and Angelman syndrome; 15q11.2 copy number variation syndrome",215.8,201.4,228.7,186.5,190.9,41.4,1.5422636103151866,0.6250493779575818,0.20272341909540026,0.693096077669082,0.44750995776752656,0.3491972965371775,3311]
["Q8N8S7","Protein enabled homolog [OS=Homo sapiens]",12,6,8,6,591,66.5,6.93,18.75,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ENAH","ENSG00000154380","Rap1 signaling pathway; Axon guidance; Regulation of actin cytoskeleton","Generation of second messenger molecules; Signaling by ROBO receptors","Regulation of actin cytoskeleton",912.4,846.2,855.3,1041.3,1148.5,876.3,0.8525162258243368,-0.2302008018725061,0.13927591014286872,0.8561239948233993,0.3775844314667016,0.4229859208027085,2696]
["Q8N9B5-1","Junction-mediating and -regulatory protein [OS=Homo sapiens]",9,7,7,7,988,111.4,6.18,11.21,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","JMY","ENSG00000152409","","Regulation of TP53 Activity through Methylation","",612.3,635.6,618.5,738.6,730.5,794.9,0.8243816254416961,-0.2786157457350454,3.4659679628170842E-3,2.46017545594295,0.06478966711056283,1.1884942514548438,391]
["Q8N9Q2","protein SREK1IP1 [OS=Homo sapiens]",5,1,1,1,155,18.2,9.85,0,"RNA metabolism OR transcription;other metabolic processes","","nucleic acid binding activity;other molecular function","SREK1IP1","ENSG00000153006","","","",405.9,368,367,421.7,376.5,11.6,1.4088663867621636,0.4945347966752899,0.4451835534767569,0.3514608882866226,0.6127771360379691,0.2126974474841187,5310]
["Q8N9R8-1","protein SCAI [OS=Homo sapiens]",7,4,6,4,606,70.4,8.6,11.07,"RNA metabolism OR transcription;other metabolic processes;other biological processes","other membranes;nucleus;other cell component","other molecular function","SCAI","ENSANAG00000024288; ENSCSAG00000013617; ENSG00000173611; ENSMMUG00000020633; ENSPPYG00000019606","","RHO GTPases Activate Formins","",518.7,551.1,562.7,569.2,571.3,1094.3,0.7304904241990335,-0.45306273363287314,0.31567158965579284,0.500764502716367,0.5369429017440517,0.2700718945162971,4297]
["Q8NB14","Ubiquitin carboxyl-terminal hydrolase 38 [OS=Homo sapiens]",5,5,6,4,1042,116.5,6.21,13.72,"protein metabolism;other metabolic processes","cytosol;nucleus","other molecular function","USP38","ENSG00000170185","","","Integrated breast cancer pathway",292.9,311.3,357,264.9,284.5,332.3,1.0901667233752976,0.12454878875737747,0.39191562341096325,0.4068074233656701,0.574626136712283,0.24061462412937162,4985]
["Q8NB37","Glutamine amidotransferase-like class 1 domain-containing protein 1 [OS=Homo sapiens]",23,4,9,4,220,23.3,6.61,30.33,"","","","GATD1","ENSG00000177225","","","",883.2,812.8,937.8,1166.8,993.1,1689.2,0.6842638538879218,-0.5473753556032052,0.12900474648350926,0.8893943103699453,0.3641930058122708,0.4386683989208444,2589]
["Q8NBB4","Zinc finger and SCAN domain-containing protein 1 [OS=Homo sapiens]",2,1,1,1,408,45.3,8.54,0,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZSCAN1","ENSG00000152467","","","",133,143.9,114,92.7,96.9,30.2,1.7784349408553228,0.8306081983400595,0.07037156677957394,1.1526027795659195,0.2711364162318956,0.566812148570609,1897]
["Q8NBJ9-1","SID1 transmembrane family member 2 [OS=Homo sapiens]",5,2,2,2,832,94.4,6.96,5.39,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle","transporter activity;nucleic acid binding activity;other molecular function","SIDT2","ENSG00000149577","","","",32.6,27.6,39,34.4,31.3,31.4,1.0216271884654995,0.03086882496768296,0.8492192909328807,0.07098014892603044,0.9002093977416136,0.04565645755392602,6895]
["Q8NBP0-1","Tetratricopeptide repeat protein 13 [OS=Homo sapiens]",12,8,11,8,860,96.8,7.01,35.48,"","","","TTC13","ENSG00000143643","","","",818.4,786.6,831.5,740.2,713.4,785.3,1.08825762651302,0.12202013057282433,0.05698556270971285,1.2442351588835598,0.24471649697138143,0.6113367527481559,1702]
["Q8NBS9-1","Thioredoxin domain-containing protein 5 [OS=Homo sapiens]",71,29,1001,28,432,47.6,5.97,2951.38,"transport;other biological processes","non-structural extracellular;ER/Golgi;other cytoplasmic organelle","other molecular function","TXNDC5","ENSG00000239264","Protein processing in endoplasmic reticulum","Golgi Associated Vesicle Biogenesis; Neutrophil degranulation; Lysosome Vesicle Biogenesis","VEGFA-VEGFR2 signaling pathway",104217.8,102766.9,107554,111578.6,111130.9,143654.6,0.8585412708286648,-0.22004060738246195,0.18689131096365855,0.7284108895695723,0.4311832676241731,0.3653381006030552,3168]
["Q8NC51-3","Isoform 3 of Plasminogen activator inhibitor 1 RNA-binding protein [OS=Homo sapiens]",46,20,124,3,393,43.1,8.44,368.7,"","","","SERBP1","","","","",16075.8,13378.5,12096.6,15624.2,14111.3,10340.7,1.0367974009511882,0.0521340067847012,0.8143588499010207,0.0891841796443895,0.8744158710043427,0.058281968365014925,6807]
["Q8NC56-1","LEM domain-containing protein 2 [OS=Homo sapiens]",29,15,39,15,503,56.9,9,105.47,"cell organization and biogenesis;developmental processes;other biological processes","other membranes;nucleus","nucleic acid binding activity","LEMD2","ENSG00000161904","","Sealing of the nuclear envelope (NE) by ESCRT-III; Initiation of Nuclear Envelope (NE) Reformation; Depolymerisation of the Nuclear Lamina","",3221.4,3147.2,3322.7,2833.9,2963.2,4367.1,0.9534739576159459,-0.06873456036759766,0.7654249123443996,0.1160974068650681,0.8402659483816787,0.0755832358017437,6658]
["Q8NCG7","Sn1-specific diacylglycerol lipase beta [OS=Homo sapiens]",17,8,18,8,672,73.7,6.55,51.15,"cell-cell signaling;cell cycle OR cell proliferation;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;nucleus","other molecular function","DAGLB","ENSG00000164535","Retrograde endocannabinoid signaling; Aldosterone synthesis and secretion","Arachidonate production from DAG","Cannabinoid receptor signaling",1338.8,1276.2,1395.5,1325.2,1254.2,1799.3,0.9159111151711695,-0.1267204964819542,0.5206990928028443,0.2834131789808506,0.664418587516758,0.17755822639667673,5728]
["Q8NCL4","Polypeptide N-acetylgalactosaminyltransferase 6 [OS=Homo sapiens]",4,3,4,2,622,71.1,8.18,13.51,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","GALNT6","ENSG00000139629","Mucin type O-glycan biosynthesis; Other types of O-glycan biosynthesis; Metabolic pathways","O-linked glycosylation of mucins","",155.7,146.9,169.4,194.7,174.3,162.2,0.8885542168674698,-0.17046828709772124,0.16197410213785027,0.7905544187767267,0.40253951462956394,0.39519148139982313,2941]
["Q8ND24","Ring finger protein 214 [OS=Homo sapiens]",8,5,7,5,703,77.6,6.95,19.94,"protein metabolism;other metabolic processes","","other molecular function","RNF214","ENSG00000167257","","","",567.8,562.5,638.5,746.3,744.3,635.3,0.8320240839173999,-0.2653028054088376,0.05414526242786693,1.2664395370339598,0.2394118106988986,0.6208544287214345,1653]
["Q8NDA8-1","Maestro heat-like repeat-containing protein family member 1 [OS=Homo sapiens]",8,15,27,15,1641,181.1,6.89,49.58,"","","","MROH1","ENSG00000179832","","","",2531,2446.6,2517,2340.3,2354.7,2622.5,1.0242022548684662,0.03450064041890693,0.5695666514478064,0.2444554468925954,0.6983664914329838,0.15591660683810007,5961]
["Q8NDX6","Zinc finger protein 740 [OS=Homo sapiens]",4,1,2,1,193,21.8,9.19,3.54,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF740","ENSG00000139651","","Generic Transcription Pathway","",86.8,85.4,88,99,93.1,330.9,0.49751434034416825,-1.0071899844165084,0.32591278333929546,0.4868986047854341,0.5442304165928513,0.26421718951457523,4377]
["Q8NE01","Metal transporter CNNM3 [OS=Homo sapiens]",13,8,8,8,707,76.1,6.09,19.59,"transport","plasma membrane;other membranes;other cell component","transporter activity","CNNM3","ENSG00000168763","","","",548.5,536.6,551.1,543.6,521.7,654.3,0.951500348918353,-0.07172390934688255,0.5375880643366304,0.2695503821608579,0.6761712549021566,0.1699432957156582,5811]
["Q8NEL9-1","Phospholipase DDHD1 [OS=Homo sapiens]",7,5,6,5,900,100.4,5.67,14.26,"other metabolic processes;other biological processes","cytosol;other cell component","other molecular function","DDHD1","ENSG00000100523","","Synthesis of PA","",558.1,551.5,573.4,548.3,555.8,599.5,0.987907959614933,-0.01755145833302617,0.710620887849212,0.14836203109334486,0.7964925731160697,0.09881826941683146,6521]
["Q8NEM2","SHC SH2 domain-binding protein 1 [OS=Homo sapiens]",28,14,44,14,672,75.6,4.75,139.46,"signal transduction;other biological processes","cytoskeleton;other cell component","","SHCBP1","ENSG00000171241","","","",2685.3,2640.8,2703.6,3476.2,3515.3,3259.1,0.7833395118334537,-0.3522903647951396,8.2754468695867792E-4,3.0822085452554875,0.03516583788942429,1.4538790302790634,172]
["Q8NEZ2","Vacuolar protein sorting-associated protein 37A [OS=Homo sapiens]",7,2,2,2,397,44.3,5.57,7.15,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","","VPS37A","ENSG00000155975","Endocytosis","Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; HCMV Late Events","7q11.23 copy number variation syndrome",264.3,305.9,290.8,376.4,363.8,420.9,0.741538196537766,-0.43140708725622345,0.009122704653177808,2.0398763851571884,0.10011688935446937,0.9994926524435165,666]
["Q8NF37","Lysophosphatidylcholine acyltransferase 1 [OS=Homo sapiens]",32,12,41,12,534,59.1,6.02,121.9,"other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","LPCAT1","ENSG00000153395","Glycerophospholipid metabolism; Ether lipid metabolism; Metabolic pathways","Neutrophil degranulation; Synthesis of PA; Acyl chain remodelling of PC; Acyl chain remodelling of PG; Synthesis of PC","",4140.6,4138.8,4426.4,4152.9,4147,5165.7,0.9435747385931561,-0.08379129966121811,0.5114163480719238,0.29122539331408936,0.6575096021209659,0.18209790045387,5685]
["Q8NFG4-1","Folliculin [OS=Homo sapiens]",7,3,3,3,579,64.4,6.23,7.92,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","FLCN","ENSG00000154803","mTOR signaling pathway; Renal cell carcinoma","Amino acids regulate mTORC1","Ciliopathies",260.7,289,294.5,364.2,320.1,150.7,1.0110179640718564,0.015808631708912144,0.9651202595991126,0.015418567665332799,0.9772878882529669,0.009977483504848174,7218]
["Q8NFT6-1","Protein DBF4 homolog B [OS=Homo sapiens]",1,1,1,1,615,67.2,8.34,0,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","DBF4B","ENSG00000161692","","","",675,626.8,614.3,610.3,596.5,1108,0.827760497667185,-0.2727146928756536,0.47624857856188285,0.3221663075339661,0.6322013913383221,0.19914455270730458,5506]
["Q8NG11-1","Tetraspanin-14 [OS=Homo sapiens]",8,2,2,2,270,30.7,6.84,5.39,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","TSPAN14","ENSCATG00000031568; ENSCSAG00000009464; ENSG00000108219; ENSGGOG00000005770; ENSMMUG00000013895; ENSMNEG00000032257; ENSNLEG00000029109; ENSPPAG00000030989; ENSPTRG00000002686","","Neutrophil degranulation; Amyloid fiber formation","",106.9,116.2,125.6,140.5,135.4,230.6,0.6884501480750247,-0.538575904911796,0.16906636319852147,0.7719427893885286,0.41094314885866096,0.38621825560507317,3007]
["Q8NH93","Olfactory receptor 1L3 [OS=Homo sapiens]",2,1,1,1,324,36.6,9.2,2.06,"signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","OR1L3","ENSG00000171481","Olfactory transduction","","",45.3,60.5,56,60.4,44.1,17.7,1.3240589198036008,0.4049673226112482,0.37495242405914236,0.42602383435062824,0.5645915260503238,0.24826564446257116,4854]
["Q8NHU6","tudor domain-containing protein 7 [OS=Homo sapiens]",4,5,5,5,1098,123.5,7.21,9.53,"developmental processes;other biological processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","TDRD7","ENSG00000196116","","","",645,685,658.3,693,675.6,463.3,1.085375839292538,0.11819469943806095,0.5240393246681636,0.280636121707928,0.6668181448467284,0.17599259105819895,5744]
["Q8NHV4","Protein NEDD1 [OS=Homo sapiens]",13,8,15,8,660,71.9,7.97,41.05,"cell cycle OR cell proliferation;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus","","NEDD1","ENSG00000139350","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",1364.5,1434.4,1402.7,1555.1,1610.2,1315,0.9377943441287415,-0.09265651674782498,0.37366567884308316,0.42751679022522043,0.5643981084240741,0.24841445044987145,4839]
["Q8NI60-1","Atypical kinase COQ8A, mitochondrial [OS=Homo sapiens]",9,6,15,6,647,71.9,6.99,44.09,"protein metabolism;other metabolic processes","other membranes;mitochondrion","kinase activity;other molecular function","COQ8A","ENSG00000163050","","","",1869,1793.1,1931.6,1892.7,1876.7,1911.7,0.9846156554188449,-0.0223674162372185,0.5194774921421239,0.2844332647578872,0.6635548741815421,0.17812315634315803,5722]
["Q8TAF3-1","WD repeat-containing protein 48 [OS=Homo sapiens]",22,11,23,11,677,76.2,7.03,55.85,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","WDR48","ENSANAG00000001805; ENSCAFG00000005066; ENSCANG00000036746; ENSCATG00000045029; ENSCCAG00000035592; ENSCSAG00000014688; ENSFCAG00000025123; ENSG00000114742; ENSGGOG00000002185; ENSLCNG00005009903; ENSMLEG00000040913; ENSMMUG00000020138; ENSMNEG00000033674; ENSNLEG00000005481; ENSPANG00000006231; ENSPPAG00000029758; ENSPTRG00000014765; ENSRROG00000029632; ENSSSCG00070011863; ENSSTOG00000011459","Fanconi anemia pathway","Fanconi Anemia Pathway; Ub-specific processing proteases; Recognition of DNA damage by PCNA-containing replication complex; Ub-specific processing proteases; Fanconi Anemia Pathway; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins; Recognition of DNA damage by PCNA-containing replication complex","DNA repair pathways, full network",2053,2008.2,2118.6,2458.9,2422.6,3523.8,0.7352265832272494,-0.4437391644998229,0.11019771310510437,0.9578274181533755,0.33927341410497386,0.46945017088797486,2374]
["Q8TAQ2","SWI/SNF complex subunit SMARCC2 [OS=Homo sapiens]",38,52,186,1,1214,132.8,5.69,556.76,"cell organization and biogenesis;developmental processes;other biological processes","nucleus","other molecular function","SMARCC2","ENSG00000139613","Thermogenesis; Hepatocellular carcinoma","RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","Tumor suppressor activity of SMARCB1; Thermogenesis",21658.3,21177.7,21231.5,24004,25466.4,19261.1,0.9321417399591162,-0.10137874946241696,0.4545327724190537,0.34243479810177946,0.6171614403884198,0.20960121603349435,5383]
["Q8TB36","ganglioside-induced differentiation-associated protein 1 [OS=Homo sapiens]",10,3,4,3,358,41.3,8.34,12.93,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;mitochondrion;other cytoplasmic organelle","","GDAP1","ENSG00000104381","","Class I peroxisomal membrane protein import","Intracellular trafficking proteins involved in CMT neuropathy",134.9,124.9,138.6,126.8,114.8,241.2,0.8251864125932064,-0.27720802868694044,0.5254137836588071,0.27949853815741066,0.6677533202507774,0.1753839438711628,5751]
["Q8TBQ9","Protein kish-A [OS=Homo sapiens]",13,1,11,1,72,8.1,8.95,25.22,"transport","other membranes;ER/Golgi","","TMEM167A","ENSG00000174695","","","",1540.8,1548.7,1544.1,1177.1,1177.3,359.7,1.7072326001252722,0.7716596302381985,0.07869318361754622,1.104062884483292,0.28772810358211376,0.5410177167174359,1999]
["Q8TBZ6","tRNA methyltransferase 10 homolog A [OS=Homo sapiens]",8,3,3,3,339,39.7,7.65,5.15,"RNA metabolism OR transcription;other metabolic processes","cytosol;cytoskeleton;mitochondrion;nucleus","nucleic acid binding activity;other molecular function","TRMT10A","ENSG00000145331","","tRNA modification in the nucleus and cytosol","",336.5,317.4,293.7,354.6,400.9,129.6,1.0706134900011295,0.09843773620297941,0.8178121757550985,0.08734642786839268,0.8764500282395915,0.05727284064089867,6820]
["Q8TCG2","Phosphatidylinositol 4-kinase type 2-beta [OS=Homo sapiens]",11,6,9,5,481,54.7,5.97,19.27,"cell organization and biogenesis;other metabolic processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","kinase activity;other molecular function","PI4K2B","ENSG00000038210","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the ER membrane","",542.8,542.1,596.3,622.5,657.6,1155.8,0.6901761156040889,-0.5349635464917342,0.21990786025930012,0.6577592471911352,0.465346424619347,0.3322236185386022,3454]
["Q8TCJ2","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [OS=Homo sapiens]",19,19,81,18,826,93.6,8.91,215.66,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi;other cell component","other molecular function","STT3B","ENSG00000163527","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum","","",11488.8,11611.3,11878.2,9802.7,10199.8,7285.3,1.2818292423720492,0.3582040875486775,0.04945592443045724,1.3057816758900491,0.22878060231785566,0.6405808009604989,1580]
["Q8TD16","Protein bicaudal D homolog 2 [OS=Homo sapiens]",42,30,63,27,824,93.5,5.44,201,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","BICD2","ENSG00000185963","","COPI-independent Golgi-to-ER retrograde traffic","",4995.9,5007.3,4915.2,6466.3,6359.7,6190,0.7845183003786285,-0.3501209937009309,8.9826901857076476E-5,4.046593578940572,0.016013288431057853,1.795519473776334,41]
["Q8TDB6-1","E3 ubiquitin-protein ligase DTX3L [OS=Homo sapiens]",1,1,1,1,740,83.5,8.06,2.45,"protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","DTX3L","ENSG00000163840","Notch signaling pathway","Antigen processing: Ubiquitination & Proteasome degradation","Notch signaling",58.9,49.7,74.7,128.3,117.4,140.9,0.4741334712881531,-1.0766348516713502,0.002446850751519998,2.611392520132508,0.055197630070554525,1.2580795684551471,324]
["Q8TDI8","Transmembrane channel-like protein 1 [OS=Homo sapiens]",1,1,2,1,760,87.7,6.52,3.9,"transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","transporter activity","TMC1","ENSG00000165091","","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea","",384.2,461.7,444.9,314.8,302.2,73.1,{"$f":"AVERAGE(S4674:U4674)/AVERAGE(V4674:X4674)","v":1.8704535574554413},{"$f":"LOG(Y4674,2)","v":0.9033881448459513},{"$f":"TTEST(V4674:X4674,S4674:U4674,2,2)","v":0.0710692122799025},1.1483184981833996,{"$f":"AA4674*7309/AE4674","v":0.2721031286295481},0.5652664646930934,1909]
["Q8TDY2-1","RB1-inducible coiled-coil protein 1 [OS=Homo sapiens]",17,26,40,26,1594,183,5.41,90.54,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RB1CC1","ENSG00000023287","Autophagy; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration","Macroautophagy","Alzheimer's disease and miRNA effects; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Malignant pleural mesothelioma; Alzheimer's disease; Senescence and autophagy in cancer",3110.5,3246.7,3292.9,3691.5,3444.4,4135.3,0.8561732557314217,-0.22402532408771428,0.061296623730603864,1.2125634461267694,0.2529740388746379,0.5969240454328711,1771]
["Q8TEA8","D-aminoacyl-tRNA deacylase 1 [OS=Homo sapiens]",35,6,23,6,209,23.4,8.24,66.76,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DTD1","ENSG00000125821","","","",2650.2,2504.1,2557,2712.2,2318.4,1590.5,1.1646554197942938,0.21990317574873453,0.3343204702553066,0.4758370309852097,0.5473898559802948,0.26170325503075903,4464]
["Q8TED0","U3 small nucleolar RNA-associated protein 15 homolog [OS=Homo sapiens]",21,12,22,12,518,58.4,9.11,54.87,"RNA metabolism OR transcription;other metabolic processes;other biological processes","ER/Golgi;nucleus;other cell component","","UTP15","ENSG00000164338","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",2817.8,2710.5,2748.9,3149.9,3011.4,4193.2,0.7993819112463182,-0.3230431676762784,0.1380124984627757,0.8600815819492933,0.37611236065042036,0.4246823935809005,2682]
["Q8TET4","neutral alpha-glucosidase c [OS=Homo sapiens]",5,2,2,2,914,104.3,6.23,6.3,"protein metabolism;other metabolic processes","","other molecular function","GANC","ENSG00000214013","Galactose metabolism; Starch and sucrose metabolism; Metabolic pathways","","",42.5,40.2,49.1,50.7,42,50.9,0.9178272980501393,-0.12370537881499957,0.3773571138001702,0.4232474584325191,0.5661131249518563,0.24709677617336506,4872]
["Q8TEU7","Rap guanine nucleotide exchange factor 6 [OS=Homo sapiens]",12,16,23,14,1601,179.3,6.4,67.06,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","RAPGEF6","ENSG00000158987","Rap1 signaling pathway; Tight junction","","",1404.4,1379.9,1492.3,1735.6,1729.3,4314.7,0.549719779937272,-0.8632317037343394,0.2467421960391275,0.6077565743046901,0.48953276624592373,0.3102182339455284,3684]
["Q8TF30","WASP homolog-associated protein with actin, membranes and microtubules [OS=Homo sapiens]",3,2,3,2,809,90.9,7.08,12.4,"cell adhesion;cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","WHAMM","ENSG00000156232","Tight junction","RHOD GTPase cycle","",138.7,124.8,129.1,128,130.1,230.8,0.8030272039271835,-0.3164792325419662,0.40070296846440523,0.39717744024028334,0.5806379850329774,0.23609455625735437,5044]
["Q8WTS6","Histone-lysine N-methyltransferase SETD7 [OS=Homo sapiens]",34,10,22,10,366,40.7,4.63,70.13,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","other molecular function","SETD7","ENSG00000145391","Lysine degradation; Metabolic pathways; FoxO signaling pathway","PKMTs methylate histone lysines","Histone modifications",2229.5,2170.5,2221.9,2499.9,2585,2431.2,0.8810287250036588,-0.18273903743889927,3.471503871662179E-3,2.4594823460517943,0.06472760662749712,1.1889104511882784,392]
["Q8WTW4","GATOR complex protein NPRL2 [OS=Homo sapiens]",10,3,4,3,380,43.6,6.52,11.64,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;other cytoplasmic organelle;other cell component","enzyme regulator activity;kinase activity","NPRL2","ENSG00000114388","mTOR signaling pathway","Amino acids regulate mTORC1","22q11.2 copy number variation syndrome",300.9,290.1,279.4,327.7,343.9,245.6,0.9489751417357175,-0.07555779833045392,0.6418233846301535,0.1925844635714234,0.7475836045038713,0.12634023184052617,6275]
["Q8WUA4-1","General transcription factor 3C polypeptide 2 [OS=Homo sapiens]",14,9,12,9,911,100.6,7.31,32.67,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","GTF3C2","ENSG00000115207; ENSPPAG00000042866; ENSPTRG00000011763","","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter","",1373.9,1400.8,1437.1,1673.2,1636.9,2452.1,0.7309361007948352,-0.45218280511982195,0.12451052899823803,0.9047939217209435,0.3594184267172677,0.444399661182288,2532]
["Q8WUF8","Protein Fam172a [OS=Homo sapiens]",11,4,5,4,416,47.9,6.09,13.07,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","ER/Golgi;nucleus","","FAM172A","ENSG00000113391","","","",205.3,209.7,227.6,233.4,226.8,204.9,0.9661705006765899,-0.04965029011705132,0.5322942157415237,0.2738482531306211,0.6724055345410986,0.17236872055861224,5786]
["Q8WUM0","Nuclear pore complex protein Nup133 [OS=Homo sapiens]",39,35,105,35,1156,128.9,5.1,328.44,"cell organization and biogenesis;other metabolic processes;transport;developmental processes","other membranes;cytosol;nucleus;other cell component","other molecular function","NUP133","ENSG00000069248","Nucleocytoplasmic transport; Amyotrophic lateral sclerosis","Separation of Sister Chromatids; Transport of Mature mRNA derived from an Intron-Containing Transcript; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; ISG15 antiviral mechanism; Transcriptional regulation by small RNAs; tRNA processing in the nucleus; Viral Messenger RNA Synthesis; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; HCMV Early Events; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Postmitotic nuclear pore complex (NPC) reformation","Ciliary landscape",9594.8,9711,9812,8540,8584.7,5453.8,1.2896250858117233,0.3669517125828696,0.10369537413259045,0.9842406171259057,0.33270829215763986,0.47793637498501435,2278]
["Q8WUX1-1","Sodium-coupled neutral amino acid transporter 5 [OS=Homo sapiens]",10,5,11,5,472,51.4,8.21,26.74,"transport","plasma membrane;other membranes","transporter activity","SLC38A5","ENSG00000017483","GABAergic synapse","Amino acid transport across the plasma membrane","Neuroinflammation and glutamatergic signaling",1562.7,1576.6,1700.5,1629.2,1621.1,1907.1,0.9384185830069416,-0.09169651231110568,0.36508728772721444,0.43760328884167204,0.5607108606846417,0.25126103175645664,4759]
["Q8WUY1","Protein THEM6 [OS=Homo sapiens]",26,5,8,5,208,23.9,9.55,20.98,"","non-structural extracellular","","THEM6","ENSG00000130193","","","",1066.7,1031,1110.6,875.1,1031.3,2520.2,0.7247774815885779,-0.46438996249598646,0.48221426496074643,0.31675994638058486,0.6357330560241875,0.19672520610036223,5544]
["Q8WVB3","Hexosaminidase D [OS=Homo sapiens]",14,4,7,4,486,53.8,5.97,9.2,"other metabolic processes","non-structural extracellular;nucleus;other cell component","other molecular function","HEXD","ENSG00000169660","Other glycan degradation; Various types of N-glycan biosynthesis; Metabolic pathways","","",460.6,422.5,455.1,439.9,476.2,855.8,0.7552344940459393,-0.40500343605023015,0.33985598249580495,0.4687050807746806,0.5489519063120085,0.26046570243192974,4525]
["Q8WVM0","Dimethyladenosine transferase 1, mitochondrial [OS=Homo sapiens]",10,3,5,3,346,39.5,9.26,9.47,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","nucleic acid binding activity;other molecular function","TFB1M","ENSG00000029639","","Transcriptional activation of mitochondrial biogenesis; rRNA modification in the mitochondrion","Energy metabolism; Mitochondrial gene expression",633.1,610.5,614.4,600.9,629.5,1067.6,0.8085291557876415,-0.3066282962634602,0.3869294313580411,0.4123682348942624,0.5708654044804041,0.24346627526010764,4954]
["Q8WVP7-1","Limb region 1 protein homolog [OS=Homo sapiens]",4,2,3,2,490,55.1,5.94,7.03,"developmental processes;signal transduction","plasma membrane;other membranes","other molecular function","LMBR1","ENSG00000105983; ENSPPYG00000018221","","","",170.9,175.3,194.6,154.2,152.3,625.6,0.5801952580195259,-0.7853895905608125,0.45445308812673135,0.34251094108714525,0.6171678969004607,0.209596672630908,5382]
["Q8WW59","SPRY domain-containing protein 4 [OS=Homo sapiens]",27,4,9,4,207,23.1,6.93,24.78,"","nucleus","","SPRYD4","ENSG00000176422","","","",881.7,920.5,840.7,718.1,629.7,508.7,1.4235927821168866,0.509536523243722,0.015630972831402135,1.8060139917721127,0.1304186991149751,0.8846601360562204,876]
["Q8WWM7-1","ataxin-2-like protein [OS=Homo sapiens]",32,28,81,27,1075,113.3,8.59,230.61,"cell organization and biogenesis;other biological processes","other membranes;cytosol;nucleus;other cell component","","ATXN2L","ENSG00000168488","Amyotrophic lateral sclerosis; Spinocerebellar ataxia; Pathways of neurodegeneration","","16p11.2 distal deletion syndrome",9843.3,9597.3,8734,14436.5,13757.8,15680.9,0.6421531981620596,-0.6390105734549293,1.3371389811881584E-3,2.8738234501604722,0.042491951363061956,1.3716933242940923,230]
["Q8WWW0-2","Isoform 2 of Ras association domain-containing protein 5 [OS=Homo sapiens]",20,5,16,5,265,30.3,8.09,42.51,"","","","RASSF5","","","","",1670.6,1636,1602.5,1937.3,2150.7,1407,0.893375796178344,-0.16266092599332577,0.4286105689134901,0.3679371240916321,0.5991039679075729,0.22249780403731478,5229]
["Q8WXB1-1","Protein N-lysine methyltransferase METTL21A [OS=Homo sapiens]",4,1,1,1,218,24.6,6.27,2.67,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","METTL21A","ENSG00000144401","","Protein methylation","",72.1,76.3,80.1,62.5,73.6,98.9,0.9723404255319148,-0.04046659150693016,0.8536641658007689,0.06871294854391174,0.9033489775355176,0.044144442666085706,6907]
["Q8WXE9-1","Stonin-2 [OS=Homo sapiens]",7,4,6,4,905,101.1,5.39,16.32,"transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","STON2","ENSG00000140022","","Cargo recognition for clathrin-mediated endocytosis","",415.3,422.9,434.9,504.1,466.4,581.2,0.8204549848553199,-0.2855039139912135,0.05351300491712584,1.2715406613919336,0.23733407338548107,0.6246399068690576,1648]
["Q8WXX7-1","Autism susceptibility gene 2 protein [OS=Homo sapiens]",1,1,1,1,1259,138.9,9.38,2.35,"cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","AUTS2","ENSG00000158321","","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","",77.5,50,60.1,83.8,76.7,669.2,0.22610582138122212,-2.14492995830564,0.33726170669513833,0.47203296659346117,0.5480315282869644,0.26119445580910156,4498]
["Q8WYP5","protein elys [OS=Homo sapiens]",23,37,83,37,2266,252.3,6.6,286.37,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity","AHCTF1","ENSG00000153207","Nucleocytoplasmic transport","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation","Gastric cancer network 2",6245.9,6414.7,6535.2,7453.9,7415.2,9060.2,0.8021881124813512,-0.3179875076819295,0.0451548819733541,1.345295288551591,0.21987810282694545,0.6578180189108884,1501]
["Q8WZ42","Titin [OS=Homo sapiens]",0,7,16,3,34350,3813.7,6.35,25.83,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus","cytoskeletal activity;kinase activity;other molecular function","TTN","ENSG00000155657","Hypertrophic cardiomyopathy; Dilated cardiomyopathy","Platelet degranulation ; Striated Muscle Contraction","Striated muscle contraction pathway",1612,1529.8,1699.4,1534.8,1489.4,794.2,1.2678608841399541,0.3423964546476822,0.2358273120134722,0.627405899114318,0.48093242843372447,0.31791593822043257,3584]
["Q92187-1","CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase [OS=Homo sapiens]",7,2,2,2,359,41.3,9.74,6.59,"protein metabolism;other metabolic processes;developmental processes","other membranes;ER/Golgi","other molecular function","ST8SIA4","ENSANAG00000034757; ENSCCAG00000025138; ENSG00000113532; ENSGGOG00000011260; ENSNLEG00000035472; ENSPPAG00000033695; ENSPPYG00000015661; ENSPTRG00000042921","","Sialic acid metabolism; NCAM1 interactions","Ectoderm differentiation",56.7,56.4,72,91.3,96.3,431.4,0.29903069466882065,-1.7416345142310532,0.2685329908694486,0.5710023510355838,0.5049415050848468,0.2967589297828773,3887]
["Q92508","Piezo-type mechanosensitive ion channel component 1 [OS=Homo sapiens]",11,19,33,19,2521,286.6,7.47,120.25,"transport;other biological processes","plasma membrane;other membranes;ER/Golgi","transporter activity","PIEZO1","ENSG00000103335","","","",2087.1,2079.6,2238,1730.6,1839.7,2975.8,0.9783993522860941,-0.03150464610582121,0.9121984075312071,0.03991069026325969,0.9438360929566241,0.0251034189487989,7064]
["Q92522","Histone H1x [OS=Homo sapiens]",54,15,108,15,213,22.5,10.76,339.77,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity","H1-10","ENSG00000184897","","","",17705.6,16497.1,16865.9,11792.9,12834.8,16936.8,1.2286590720446533,0.2970846526478668,0.12052841464270353,0.9189105558459757,0.35280023332940336,0.45247113631335045,2497]
["Q92544","Transmembrane 9 superfamily member 4 [OS=Homo sapiens]",20,12,30,12,642,74.5,6.54,95.66,"cell adhesion;cell organization and biogenesis;stress response;transport;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","","TM9SF4","ENSG00000101337","","","",2744.7,2881.6,2997.5,2820.1,2629.9,2889.2,1.0341279739063698,0.048414731006566486,0.42350507221247835,0.37314138386763335,0.596186165793722,0.22461810577597316,5192]
["Q92551","Inositol hexakisphosphate kinase 1 [OS=Homo sapiens]",7,2,2,2,441,50.2,7.24,4.45,"other metabolic processes;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","IP6K1","ENSG00000176095","Phosphatidylinositol signaling system","Synthesis of pyrophosphates in the cytosol; Synthesis of IPs in the nucleus","",274.7,246.7,243.1,253.9,290.2,124.1,1.1441185273870098,0.1942365189131967,0.5661261918822602,0.24708675197497215,0.6957821315734724,0.1575267285902766,5947]
["Q92576-1","PHD finger protein 3 [OS=Homo sapiens]",11,13,21,13,2039,229.3,6.96,77.84,"RNA metabolism OR transcription;other metabolic processes;developmental processes","","other molecular function","PHF3","ENSG00000118482","","","",1294.4,1271.5,1304,2066.4,2126.5,3624.3,0.49504937829401835,-1.0143556620849923,0.06122359471954243,1.2130811745585353,0.25295831193054585,0.5969510455842854,1769]
["Q92609-1","TBC1 domain family member 5 [OS=Homo sapiens]",28,15,26,15,795,88.9,6.54,79.85,"other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","TBC1D5","ENSG00000131374","","","",828.7,837.7,831.2,890.1,890.9,900.7,0.9313495170973637,-0.10260541050357515,1.4480141703258705E-4,3.839227188094521,0.01707021866276095,1.767760915708802,62]
["Q92613","protein jade-3 [OS=Homo sapiens]",5,4,4,4,823,93.7,7.18,7.19,"protein metabolism;other metabolic processes","nucleus","other molecular function","JADE3","ENSG00000102221","","HATs acetylate histones","",181.5,183.2,210.8,216.1,211.7,575.8,0.5734356317257873,-0.8022965423895796,0.30366336286587525,0.5176076027639802,0.5279437486171936,0.27741234823621186,4204]
["Q92622-1","Run domain Beclin-1-interacting and cysteine-rich domain-containing protein [OS=Homo sapiens]",7,5,8,5,972,108.6,6.25,16.64,"other metabolic processes;transport;other biological processes","cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RUBCN","ENSG00000145016","Autophagy","","",726.9,709.8,716,813,733.9,1170,0.7923368545032942,-0.3358141860443178,0.23381460736749707,0.6311283601505253,0.4803122443083294,0.3184763420144586,3558]
["Q92696","geranylgeranyl transferase type-2 subunit alpha [OS=Homo sapiens]",30,14,42,14,567,65,5.67,113.42,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","RABGGTA","ENSG00000100949; ENSG00000285193","","RAB geranylgeranylation; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain","",4273.5,4200.8,4262.5,4336.4,4057.9,6456.2,0.8576680919834347,-0.22150864610293217,0.4050346963768709,0.3925077723418831,0.583905048484921,0.2336577697912461,5070]
["Q92747","Actin-related protein 2/3 complex subunit 1A [OS=Homo sapiens]",19,6,19,5,370,41.5,8.18,61.41,"cell organization and biogenesis","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity","ARPC1A","ENSG00000241685","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection","Clathrin-mediated endocytosis; FCGR3A-mediated phagocytosis; EPHB-mediated forward signaling; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs","Pathogenic Escherichia coli infection",2371.3,2477.4,2372.6,2208.8,2134.5,2058.3,1.1280461134716322,0.173826044968115,0.008107361711878884,2.0911204503984515,0.09420780087777865,1.0259131339597474,629]
["Q92793-1","CREB-binding protein [OS=Homo sapiens]",8,15,27,8,2442,265.2,8.53,70.88,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CREBBP","ENSG00000005339","cAMP signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Cell cycle; Wnt signaling pathway; Notch signaling pathway; TGF-beta signaling pathway; Adherens junction; JAK-STAT signaling pathway; Long-term potentiation; Melanogenesis; Thyroid hormone signaling pathway; Glucagon signaling pathway; Growth hormone synthesis, secretion and action; Huntington disease; Tuberculosis; Hepatitis B; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Pathways in cancer; Viral carcinogenesis; MicroRNAs in cancer; Renal cell carcinoma; Prostate cancer","Heme signaling; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RORA activates gene expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; HATs acetylate histones; SUMOylation of transcription cofactors; Pre-NOTCH Transcription and Translation; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production; Formation of the beta-catenin:TCF transactivating complex; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation; Attenuation phase; CD209 (DC-SIGN) signaling; Activation of the TFAP2 (AP-2) family of transcription factors; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Regulation of gene expression by Hypoxia-inducible Factor; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells","Androgen receptor signaling pathway; Angiogenesis; TNF-alpha signaling pathway; Notch signaling; Initiation of transcription and translation elongation at the HIV-1 LTR; IL-6 signaling pathway; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Wnt signaling pathway and pluripotency; Clear cell renal cell carcinoma pathways; Ebola virus pathway in host; Type 2 papillary renal cell carcinoma; Ciliary landscape; Hepatitis B infection; Male infertility; TGF-beta receptor signaling in skeletal dysplasias; Overlap between signal transduction pathways contributing to LMNA laminopathies; 15q13.3 copy number variation syndrome; TGF-beta receptor signaling; Sudden infant death syndrome (SIDS) susceptibility pathways",1840.7,1813.6,1864.9,2357.5,2433.6,1857.4,0.8301421373242086,-0.268569718359782,0.10650899280450041,0.9726137221736906,0.33569393204316234,0.474056508927705,2319]
["Q92797-1","Symplekin [OS=Homo sapiens]",28,34,94,34,1274,141.1,6.13,244.46,"cell adhesion;RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","","SYMPK","ENSG00000125755","mRNA surveillance pathway; Tight junction","mRNA Splicing - Major Pathway; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs","",10903.5,10824.7,11389.6,12437.5,12592.7,13783.1,0.8532590632592436,-0.22894426127406703,0.014556730008134774,1.8369361730256941,0.1253181856648493,0.9019859013856738,849]
["Q92845","Kinesin-associated protein 3 [OS=Homo sapiens]",10,7,10,6,792,91.1,5.08,27.94,"cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","KIFAP3","ENSG00000075945","","COPI-dependent Golgi-to-ER retrograde traffic; Translocation of SLC2A4 (GLUT4) to the plasma membrane; MHC class II antigen presentation; Kinesins; Intraflagellar transport","Genes related to primary cilium development (based on CRISPR)",351.5,330.4,362.8,388.8,370.6,430.5,0.8779729389024287,-0.18775162154236127,0.07383146468865254,1.1317585158401675,0.278018637511263,0.5559260893445575,1941]
["Q92882","osteoclast-stimulating factor 1 [OS=Homo sapiens]",37,5,15,5,214,23.8,5.68,53.68,"signal transduction;other biological processes","other cell component","other molecular function","OSTF1","ENSG00000134996","","Neutrophil degranulation","",1231.1,1366.3,1215.3,1365.7,1370.2,1973.4,0.8096107701781581,-0.3046996126870725,0.22307660274551352,0.6515459780414754,0.4694693030426024,0.3283927994682648,3473]
["Q92890-1","Isoform Long of Ubiquitin recognition factor in ER-associated degradation protein 1 [OS=Homo sapiens]",37,13,34,13,343,38.7,6.34,102.54,"","","","UFD1","","","","",4335.4,4338.6,4421,4680.2,4671.1,5170.7,0.9017352981682963,-0.1492240982857674,0.046795412725681815,1.329796717985011,0.2232556603211543,0.6511975213976232,1532]
["Q92918","mitogen-activated protein kinase kinase kinase kinase 1 [OS=Homo sapiens]",23,14,25,14,833,91.2,8.34,62.26,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes","","kinase activity;other molecular function","MAP4K1","ENSG00000104814; ENSG00000282928","MAPK signaling pathway","","B cell receptor signaling pathway; Cardiac hypertrophic response; Hepatocyte growth factor receptor signaling; TGF-beta signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; EGF/EGFR signaling pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Insulin signaling; Modulators of TCR signaling and T cell activation; Malignant pleural mesothelioma; T-cell receptor (TCR) signaling pathway",1697.9,1728.2,1701.3,1601.1,1634,2020.1,0.97568123001979,-0.0355182206521242,0.7678869042744957,0.11470273890903948,0.8423360923521369,0.07451459029320297,6663]
["Q92963","GTP-binding protein Rit1 [OS=Homo sapiens]",17,2,3,2,219,25.1,9.1,10.42,"signal transduction","plasma membrane;other membranes","other molecular function","RIT1","ENSG00000143622","","Signalling to p38 via RIT and RIN","Ectoderm differentiation; Ectoderm differentiation",107.4,96,109,111.9,101.5,135.3,0.8958990536277601,-0.1585919106347254,0.32529363677585127,0.4877244320767813,0.5436933892510168,0.2646459475376654,4373]
["Q92966","snRNA-activating protein complex subunit 3 [OS=Homo sapiens]",11,2,2,2,411,46.7,5.27,3.54,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SNAPC3","ENSG00000164975","","RNA polymerase II transcribes snRNA genes; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter","",8.1,16.5,19.8,15.9,16.3,317.4,0.12700228832951949,-2.977073603150492,0.3686379633792171,0.43339994194080395,0.5621478978382428,0.2501494090486189,4793]
["Q92997","segment polarity protein dishevelled homolog DVL-3 [OS=Homo sapiens]",11,6,9,4,716,78,6.65,16.05,"cell-cell signaling;developmental processes;signal transduction;other biological processes","cytosol;other cell component","signal transduction activity or receptor binding;other molecular function","DVL3","ENSG00000161202","mTOR signaling pathway; Wnt signaling pathway; Notch signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer","WNT mediated activation of DVL; Degradation of DVL; RHO GTPases Activate Formins; PCP/CE pathway; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Negative regulation of TCF-dependent signaling by DVL-interacting proteins; WNT5:FZD7-mediated leishmania damping","Alzheimer's disease and miRNA effects; Neural crest differentiation; Notch signaling; Wnt signaling pathway; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Ciliary landscape; Joubert syndrome; Malignant pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)",768.9,707.8,753.7,795.1,785.1,2214,0.5878446049233039,-0.7664932618250658,0.33408836918289264,0.476138643450806,0.5471323975706391,0.2619075684073624,4463]
["Q93034","Cullin-5 [OS=Homo sapiens]",22,18,47,18,780,90.9,7.94,120.07,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;transport;signal transduction","cytosol;other cell component","transporter activity;other molecular function","CUL5","ENSG00000166266","Ubiquitin mediated proteolysis; Human immunodeficiency virus 1 infection","Antigen processing: Ubiquitination & Proteasome degradation; Vif-mediated degradation of APOBEC3G; Neddylation; Inactivation of CSF3 (G-CSF) signaling; Downregulation of ERBB2 signaling","Apoptosis-related network due to altered Notch3 in ovarian cancer; Dual hijack model of Vif in HIV infection; Modulators of TCR signaling and T cell activation",4738.6,4718.5,4780.3,4815.3,4629,3492.8,1.1005093877298624,0.1381714519750873,0.3539052596396848,0.45111298295299657,0.5565175436115438,0.254521140451298,4648]
["Q93086-1","Isoform 2 of P2X purinoceptor 5 [OS=Homo sapiens]",6,2,2,2,421,47.1,7.28,7.62,"","","","P2RX5","","","","",359.8,363.4,383.7,349.1,274.4,254.6,1.2605625782940442,0.3340677398969854,0.06222816856496743,1.2060129805330118,0.2538089754695016,0.5954930239751454,1792]
["Q969F2-1","protein naked cuticle homolog 2 [OS=Homo sapiens]",3,1,1,1,451,50,7.96,4.31,"cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","NKD2","ENSG00000145506; ENSG00000276920","Wnt signaling pathway; Hippo signaling pathway","","Wnt signaling pathway and pluripotency; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma",23.2,18.7,28.3,20.4,21.2,81,0.5725938009787929,-0.8044160433862207,0.4372102896088953,0.359309625615796,0.6066002290720227,0.21709743002156923,5268]
["Q969H4","Connector enhancer of kinase suppressor of Ras 1 [OS=Homo sapiens]",8,3,3,3,720,79.7,5.38,10.8,"signal transduction","plasma membrane;other membranes;other cell component","other molecular function","CNKSR1","ENSG00000142675","","Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants","",58.4,75.5,57.5,82.3,79.1,88.5,0.7659063625450181,-0.3847600716006781,0.03945766786629551,1.403868587171256,0.20614445635078904,0.6858283397791106,1399]
["Q969M1","Mitochondrial import receptor subunit TOM40B [OS=Homo sapiens]",5,2,6,2,308,33.9,7.24,24.12,"cell organization and biogenesis;transport","other membranes;mitochondrion;other cell component","transporter activity;other molecular function","TOMM40L","ENSG00000158882","Amyotrophic lateral sclerosis; Pathways of neurodegeneration","","",367.2,405.3,417.2,336.9,377.6,679.3,0.8535657913617449,-0.2284257369322806,0.5664879068552708,0.24680935683691743,0.6959926224920447,0.15739536387790964,5949]
["Q969R5-1","Lethal(3)malignant brain tumor-like protein 2 [OS=Homo sapiens]",2,1,1,1,705,79.1,6.84,4.57,"cell organization and biogenesis;other biological processes","nucleus","other molecular function","L3MBTL2","ENSG00000100395","","SUMOylation of chromatin organization proteins; Transcriptional Regulation by E2F6","",91.7,90,89,135.2,130.1,288.8,0.4885399747338027,-1.0334514794886303,0.14387868779838042,0.8420035316856174,0.38170937536056715,0.41826717298944827,2755]
["Q969S9","Ribosome-releasing factor 2, mitochondrial [OS=Homo sapiens]",15,12,19,11,779,86.5,6.51,52.92,"cell organization and biogenesis;protein metabolism;other metabolic processes","mitochondrion","other molecular function","GFM2","ENSG00000164347","","Mitochondrial translation termination","",2877.6,2772.8,2927,2776.4,2718.5,2843.1,1.0287119213240585,0.04083902901027162,0.2407970706265198,0.6183488007135332,0.48351257945308607,0.3155922224786162,3640]
["Q969V6","MKL/myocardin-like protein 1 [OS=Homo sapiens]",2,2,3,1,931,98.9,5.86,5.08,"cell organization and biogenesis;stress response;other biological processes","cytosol;nucleus;other cell component","cytoskeletal activity;other molecular function","MRTFA","ENSG00000196588","","RHO GTPases Activate Formins; SUMOylation of transcription cofactors","",40.5,39.1,42.5,47.7,47.3,138.9,0.5220179563916203,-0.9378286613650245,0.2886092141582435,0.5396898077047518,0.5193118528514529,0.28457176488956676,4062]
["Q969X6","U3 small nucleolar RNA-associated protein 4 homolog [OS=Homo sapiens]",8,6,11,6,686,76.8,8.85,25.28,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","UTP4","ENSG00000141076; ENSG00000262788","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",1087.9,1146.4,1126.3,1154.1,1180.9,1315.6,{"$f":"AVERAGE(S4994:U4994)/AVERAGE(V4994:X4994)","v":0.9205610036706297},{"$f":"LOG(Y4994,2)","v":-0.11941476573269229},{"$f":"TTEST(V4994:X4994,S4994:U4994,2,2)","v":0.14128714549290083},0.8498973490888188,{"$f":"AA4994*7309/AE4994","v":0.3799366248740295},0.42028883960132124,2718]
["Q96A26","Protein FAM162A [OS=Homo sapiens]",12,2,6,2,154,17.3,9.77,21.68,"stress response;other biological processes","other membranes;cytosol;mitochondrion","","FAM162A","ENSG00000114023","","","",464.8,662.6,515.7,637.5,644.6,379.6,0.9888066437985197,-0.016239658134783386,0.9559271326009611,0.019575211401115407,0.9720188386450228,0.012325317954078683,7188]
["Q96AA3","Protein RFT1 homolog [OS=Homo sapiens]",5,3,6,3,541,60.3,8.85,12.36,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport","other membranes;ER/Golgi","transporter activity","RFT1","ENSG00000163933","","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective RFT1 causes CDG-1n","",604.7,599.2,604.3,544.3,554.9,433.3,1.1799021207177816,0.23866718517019594,0.07759539772200093,1.110164036515162,0.2860034099597099,0.5436287888364916,1983]
["Q96AC1","Fermitin family homolog 2 [OS=Homo sapiens]",3,2,2,2,680,77.8,6.7,1.98,"cell adhesion;cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","FERMT2","ENSG00000073712","","RAC1 GTPase cycle; RAC3 GTPase cycle; Cell-extracellular matrix interactions","",104.1,98.6,120.7,106.7,88.4,124,1.013475399561266,0.01931107019434952,0.9124077604836539,0.039811029488227095,0.9439190829971729,0.02506523378883156,7065]
["Q96AJ9-1","Isoform 1 of Vesicle transport through interaction with t-SNAREs homolog 1A [OS=Homo sapiens]",34,7,13,6,203,23.4,6.15,32.44,"","","","VTI1A","","","","",1465.1,1478.9,1533.5,1518.5,1449.6,1486.4,1.0051633179930408,7.429928186403487E-3,0.8035735211319992,0.09497438229676265,0.8678071610451805,0.06157677044375685,6768]
["Q96AY2","crossover junction endonuclease EME1 [OS=Homo sapiens]",4,1,1,1,570,63.2,7.05,0,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","EME1","ENSG00000154920","Homologous recombination; Fanconi anemia pathway","Fanconi Anemia Pathway; Resolution of D-loop Structures through Holliday Junction Intermediates","",19.5,18.6,13.4,17.9,18.2,4.9,1.25609756097561,0.32894852256513496,0.5045150631401687,0.297125862646108,0.6524240262723803,0.185470053938656,5652]
["Q96AZ6-1","Interferon-stimulated gene 20 kDa protein [OS=Homo sapiens]",38,6,28,6,181,20.4,8.92,94.24,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ISG20","ENSG00000172183; ENSGGOG00000010365; ENSPTRG00000044668","","Interferon alpha/beta signaling","",2316.8,2340.8,2407.3,3119.9,2690.3,2242.1,0.8773766501496466,-0.18873178283334496,0.2661277817474848,0.5749097859903753,0.503267259195955,0.29820132236074615,3865]
["Q96BD0","solute carrier organic anion transporter family member 4A1 [OS=Homo sapiens]",7,5,8,5,722,77.1,7.83,22.06,"transport","plasma membrane;other membranes","transporter activity","SLCO4A1","ENSG00000101187","","Transport of organic anions","",857.3,838.8,883.8,873.2,829.8,1424.6,0.8248816984269087,-0.27774086683909605,0.3952672045320915,0.4031092177379723,0.5765332264867405,0.23917565859647605,5011]
["Q96BI3-1","gamma-secretase subunit APH-1A [OS=Homo sapiens]",5,2,3,2,265,29,7.9,9.98,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle","enzyme regulator activity;other molecular function","APH1A","ENSANAG00000030676; ENSCANG00000034955; ENSCATG00000033983; ENSCCAG00000036376; ENSCSAG00000018098; ENSG00000117362; ENSGGOG00000017118; ENSMLEG00000037901; ENSMNEG00000034177; ENSNLEG00000009799; ENSPANG00000008739; ENSPPAG00000033416; ENSPPYG00000000905; ENSPTRG00000001250; ENSRBIG00000035934; ENSRROG00000045010; ENSSBOG00000025150","Notch signaling pathway; Alzheimer disease","Amyloid fiber formation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; EPH-ephrin mediated repulsion of cells; NOTCH2 Activation and Transmission of Signal to the Nucleus; Activated NOTCH1 Transmits Signal to the Nucleus; Nuclear signaling by ERBB4; NOTCH4 Activation and Transmission of Signal to the Nucleus; NRIF signals cell death from the nucleus; Regulated proteolysis of p75NTR; Noncanonical activation of NOTCH3","Alzheimer's disease and miRNA effects; Notch signaling; Alzheimer's disease; Notch signaling pathway (Netpath); Notch signaling pathway; Delta-Notch signaling pathway",479.2,463.3,479.1,556.3,523,475.5,0.9143298173398507,-0.1292134263105191,0.13839214466559122,0.8588885603504098,0.3763051284824428,0.4244598628482245,2688]
["Q96BR5","Cytochrome c oxidase assembly factor 7 [OS=Homo sapiens]",39,8,16,8,231,25.7,6.02,41.77,"","mitochondrion;nucleus","","COA7","ENSG00000162377","Thermogenesis","","",1790.2,1859.5,1829,2468.3,2416.3,1953.5,0.8012020882993813,-0.31976191340819077,0.051437732992473784,1.2887181802579146,0.2330802172609987,0.6324945857629031,1613]
["Q96BY9","Store-operated calcium entry-associated regulatory factor [OS=Homo sapiens]",5,1,1,1,339,37,7.58,2.79,"transport;other biological processes","other membranes;ER/Golgi;other cell component","","SARAF","ENSG00000133872","","","",75.5,82.9,76.8,96.1,99.2,189.2,0.611703511053316,-0.7090955380128245,0.179367166394757,{"$f":"-LOG10(AA5059)","v":0.7462570527000236},0.42235651391085016,{"$f":"-LOG10(AC5059)","v":0.37432080340220153},3104]
["Q96C01","Protein FAM136A [OS=Homo sapiens]",54,7,9,7,138,15.6,7.61,27.53,"","other cell component","","FAM136A","ENSG00000035141","","","",695.8,882.7,756.8,1009.1,1089.2,838.8,0.7951040141636307,-0.3307844912170618,0.09490270331528022,1.0227214164643024,0.31731192064564645,0.49851361219401347,2186]
["Q96C92-4","Isoform 4 of Serologically defined colon cancer antigen 3 [OS=Homo sapiens]",6,1,1,1,362,40,4.88,2.97,"","","","ENTR1","","","","",19.4,16.3,23.4,18.1,23.8,34.3,0.7755905511811023,-0.3666328673157897,0.33214623858034714,0.47867066140111314,0.5457861640700894,0.2629774780911412,4448]
["Q96CM4","Nucleoredoxin-like protein 1 [OS=Homo sapiens]",4,1,3,1,212,23.9,4.84,6.94,"other biological processes","other cell component","","NXNL1","ENSG00000171773","","","",578.9,569.9,677.5,582,612.8,584.8,1.026241852101596,0.037370767699269565,0.6864465143603168,0.16339329589714102,0.7793161810282005,0.10828630636276279,6438]
["Q96CM8","Acyl-CoA synthetase family member 2, mitochondrial [OS=Homo sapiens]",19,10,15,10,615,68.1,7.55,41.94,"other metabolic processes","mitochondrion","other molecular function","ACSF2","ENSG00000167107","","Mitochondrial Fatty Acid Beta-Oxidation","Mitochondrial long chain fatty acid beta-oxidation",1160.3,1148.6,1212.5,1234.5,1116.5,1513.5,0.9112174925604863,-0.1341326522881837,0.3921357628116925,0.40656354820345897,0.5748335921361132,0.24045786048724063,4986]
["Q96CV9-2","Isoform 2 of Optineurin [OS=Homo sapiens]",41,23,58,1,571,65.2,5.17,167.77,"","","","","","","","",100.7,97,99.2,94.5,91.1,97.3,1.049487451396253,0.06968491659040275,0.08931915476165843,1.0490553953641968,0.3067827547711285,0.5131690571032346,2128]
["Q96CW6","Probable RNA polymerase II nuclear localization protein SLC7A6OS [OS=Homo sapiens]",42,7,11,7,309,35,4.6,35.29,"transport;developmental processes;other biological processes","nucleus;other cell component","","SLC7A6OS","ENSG00000103061","","","",415.1,432.7,395.7,445.7,471.8,540.2,0.8530561844000822,-0.22928733073417304,0.07687036007594496,1.1142410846048616,0.28462282765708297,0.5457302710545064,1974]
["Q96D71","RalBP1-associated Eps domain-containing protein 1 [OS=Homo sapiens]",19,9,15,9,796,86.6,5.69,50,"transport","plasma membrane;other membranes;cytosol","other molecular function","REPS1","ENSG00000135597","","Cargo recognition for clathrin-mediated endocytosis","",1145.6,1133.6,1156,1216.3,1242,1006.1,0.9915714120771273,-0.01221141709836499,0.9030053841103568,0.04430966022642006,0.9383091203387259,0.02765406232337085,7034]
["Q96DI7","U5 small nuclear ribonucleoprotein 40 kDa protein [OS=Homo sapiens]",35,10,29,10,357,39.3,8.1,88.99,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","","SNRNP40","ENSG00000060688","Spliceosome","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","mRNA processing",3455.4,3379.4,3612.8,3716.6,3518.5,2539.9,1.0688081841432224,0.09600296005936643,0.5774273145290161,0.23850267617291004,0.7049300554355401,0.15185397243462193,5987]
["Q96DP5","Methionyl-tRNA formyltransferase, mitochondrial [OS=Homo sapiens]",7,3,7,3,389,43.8,9.66,12.69,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion","other molecular function","MTFMT","ENSG00000103707","One carbon pool by folate; Aminoacyl-tRNA biosynthesis; Metabolic pathways","Mitochondrial translation initiation","One-carbon metabolism",281.7,279.2,305.2,249.7,254.4,202.6,1.2255553983302672,0.2934356992924393,0.04534970985866132,1.3434254871526279,0.219947597449871,0.6576807775832867,1507]
["Q96E11","Ribosome-recycling factor, mitochondrial [OS=Homo sapiens]",27,5,18,5,262,29.3,9.79,55.07,"cell organization and biogenesis;protein metabolism;other metabolic processes","mitochondrion","translation activity","MRRF","ENSG00000148187","","Mitochondrial translation termination","",1702.1,1842.6,1608.4,1519,1811.9,1246.7,1.1257209017825935,0.17084918663245147,0.33897007467490103,0.4698386409627706,0.5486121071299495,0.26073461233172784,4516]
["Q96ED9-2","Isoform 2 of Protein Hook homolog 2 [OS=Homo sapiens]",16,10,11,10,717,83,5.47,26.51,"","","","HOOK2","","","","",715.3,701.1,720,917.4,973.5,1729,0.5901820492278792,-0.7607680539611552,0.13186743933105696,0.8798624270809364,0.36815092210492567,0.4339741074117005,2618]
["Q96EE3","nucleoporin Seh1 [OS=Homo sapiens]",29,9,23,9,360,39.6,8.09,84.51,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","SEH1L","ENSG00000085415","Nucleocytoplasmic transport; mTOR signaling pathway; Amyotrophic lateral sclerosis","Amino acids regulate mTORC1","",2623.8,2860.9,2873.8,3056.7,2473.5,1927.1,1.1208480281066875,0.1645906813906397,0.4219779153139433,0.3747102777309072,0.5950678338857055,0.2254335246864654,5183]
["Q96EP0-1","E3 ubiquitin-protein ligase RNF31 [OS=Homo sapiens]",11,9,15,9,1072,119.6,6.57,36.21,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","RNF31","ENSG00000092098; ENSG00000285152","Necroptosis; NOD-like receptor signaling pathway; Shigellosis","Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway","Regulation of toll-like receptor signaling pathway",1010.5,1008.2,1052.7,1041.2,1028.9,1726.4,0.8090082971157644,-0.30577359600666565,0.35434373812489844,0.45057523757956913,0.5564886940169494,0.2545436546463073,4654]
["Q96ES6","Major facilitator superfamily domain-containing protein 3 [OS=Homo sapiens]",2,1,1,1,412,42.7,9.17,2.16,"transport","other membranes","transporter activity","MFSD3","ENSG00000167700","","","",44.6,47.5,47,40.9,54.3,90.4,0.7494612068965517,-0.4160742905853331,0.35432847227290687,0.45059394827595384,0.5565843120229264,0.25446903892524825,4653]
["Q96EX1","small integral membrane protein 12 [OS=Homo sapiens]",12,1,2,1,92,10.8,8.44,6.31,"","other membranes","","SMIM12","ENSG00000163866","","","",112.3,104.6,106.1,121,119.9,143.6,0.8400520156046815,-0.25144943326790153,0.06406483827293455,1.1933802658612198,0.2554554844172824,0.5926847689394636,1833]
["Q96F10","Diamine acetyltransferase 2 [OS=Homo sapiens]",13,3,6,3,170,19.1,6.04,4.77,"other metabolic processes","other cell component","other molecular function","SAT2","ENSG00000141504","Arginine and proline metabolism; Metabolic pathways; Ferroptosis","","Ferroptosis",632.7,618.1,679.4,648.7,568.8,674.9,1.0199746353836399,0.028533275862228306,0.7497947397421405,0.12505761073892174,0.8282076096078744,0.08186078349854427,6617]
["Q96FF9","Sororin [OS=Homo sapiens]",6,1,1,1,252,27.6,9.61,2.45,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","CDCA5","ENSG00000146670","MicroRNAs in cancer","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion","",72.8,64.1,59.7,55,48.7,42.3,1.3465753424657532,0.4292949525732008,0.03375892432300737,1.4716113999618095,0.1915714113950783,0.7176693011016299,1288]
["Q96FL9","Polypeptide N-acetylgalactosaminyltransferase 14 [OS=Homo sapiens]",3,1,1,1,552,64.3,7.72,3.54,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","GALNT14","ENSG00000158089","Mucin type O-glycan biosynthesis; Other types of O-glycan biosynthesis; Metabolic pathways","O-linked glycosylation of mucins","",58.3,53.5,51.6,49.5,59,67.5,0.928409090909091,-0.10716744537897609,0.4926343570523895,0.3074753030979184,0.6429758063742705,0.1918053682201458,5600]
["Q96G01","Protein bicaudal D homolog 1 [OS=Homo sapiens]",11,9,13,6,975,110.7,5.81,36.9,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","BICD1","ENSG00000151746","","COPI-independent Golgi-to-ER retrograde traffic","",489.8,508.6,488.7,632.6,634,860.6,0.69908800300865,-0.5164540176661845,0.04851957176776413,1.3140830408581796,0.22732663464781283,0.6433496773286682,1560]
["Q96G03","Phosphoglucomutase-2 [OS=Homo sapiens]",35,23,61,22,612,68.2,6.73,151.91,"other metabolic processes","non-structural extracellular;cytosol;other cell component","other molecular function","PGM2","ENSG00000169299","Glycolysis / Gluconeogenesis; Pentose phosphate pathway; Galactose metabolism; Purine metabolism; Starch and sucrose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars","Neutrophil degranulation; Glycogen breakdown (glycogenolysis); Glycogen synthesis; Pentose phosphate pathway; Galactose catabolism","Clear cell renal cell carcinoma pathways; Glucuronidation",7203.8,7172.4,7303.6,6750.5,6653,5366.7,1.1550116674302886,0.20790742519873498,0.09618175113565461,1.016907320195995,0.31896207760911954,0.4962609484917695,2204]
["Q96GA7","serine dehydratase-like [OS=Homo sapiens]",20,4,11,4,329,34.7,6.89,56.45,"other metabolic processes","cytosol","other molecular function","SDSL","ENSG00000139410","Glycine, serine and threonine metabolism; Cysteine and methionine metabolism; Valine, leucine and isoleucine biosynthesis; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids","Threonine catabolism","Clear cell renal cell carcinoma pathways",664.9,677.2,678.7,660.8,862.7,1307.7,0.7137609494207404,-0.48648712263767796,0.23045272390449079,0.6374181542363657,0.47662109762816157,0.32182673752313806,3534]
["Q96GD0","Pyridoxal phosphate phosphatase [OS=Homo sapiens]",36,8,19,8,296,31.7,6.55,69.41,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","PDXP","ENSG00000241360","Vitamin B6 metabolism; Metabolic pathways; Biosynthesis of cofactors","","",1786.6,1844.7,1856.2,1737.1,1658.7,1715.5,1.0736016277659304,0.10245876402783476,0.016894650755234844,1.7722507814944142,0.13465976267176824,0.8707621552804622,917]
["Q96GM1-2","Isoform 2 of Phospholipid phosphatase-related protein type 2 [OS=Homo sapiens]",2,1,2,1,427,45.5,9.52,0,"","","","PLPPR2","","","","",75.1,88,93.9,91.4,97,71.1,0.9903660886319846,-0.013966179164002673,0.9351930408842015,0.029098733579359184,0.9589402266866763,0.018208462724204597,7128]
["Q96GY0","Zinc finger C2HC domain-containing protein 1A [OS=Homo sapiens]",7,2,3,2,325,35.1,9.82,8.43,"","","other molecular function","ZC2HC1A","ENSG00000104427","","","",65.5,46.6,53.6,76,75.8,75.4,0.72931338028169,-0.45538923228323047,0.02058086743552044,1.6865363246891916,0.14791107186452201,0.8299993157279631,1017]
["Q96HA7","Tonsoku-like protein [OS=Homo sapiens]",15,17,36,17,1378,150.8,6.42,111.68,"DNA metabolism;other metabolic processes;stress response","nucleus;other cell component","other molecular function","TONSL","ENSG00000160949","","","",1743,1685.3,1794,1758,1805,2267.3,0.8957172015162169,-0.15888478265979916,0.2879386987269651,0.5406999623739936,0.5188717822966933,0.28493994681530027,4056]
["Q96HE7","ERO1-like protein alpha [OS=Homo sapiens]",47,15,84,13,468,54.4,5.68,301.52,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","ERO1A","ENSG00000197930","Protein processing in endoplasmic reticulum; Vibrio cholerae infection; Lipid and atherosclerosis","Insulin processing; Detoxification of Reactive Oxygen Species","",8773.2,8714.1,9016.9,8106.4,8491.4,6666.4,1.1392697793175783,0.1881094179832923,0.12756057328761844,0.8942835376017834,0.36221454163139205,0.44103411828617833,2574]
["Q96HY7","Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial [OS=Homo sapiens]",10,7,11,7,919,103,6.93,32.57,"other metabolic processes;developmental processes","mitochondrion","other molecular function","DHTKD1","ENSG00000181192","Lysine degradation; Tryptophan metabolism; Metabolic pathways","Glyoxylate metabolism and glycine degradation","Integrated breast cancer pathway",751.5,709.1,751.7,664.1,649,558.4,1.1820999198503874,0.24135198795198648,0.034092699320090576,1.4673386117540934,0.19256842297568935,0.715414926202802,1294]
["Q96I15-1","selenocysteine lyase [OS=Homo sapiens]",20,7,12,7,445,48.1,7.12,36.49,"other metabolic processes","cytosol;ER/Golgi;other cell component","other molecular function","SCLY","ENSG00000132330","Selenocompound metabolism; Metabolic pathways","Metabolism of ingested SeMet, Sec, MeSec into H2Se","",1502.1,1427.7,1488.2,1424.6,1481.6,3511.3,0.6884300740163616,-0.5386179721075058,0.3866814053660428,0.41264671166390093,0.5708451609413062,0.243481676111412,4951]
["Q96IJ6","Mannose-1-phosphate guanyltransferase alpha [OS=Homo sapiens]",32,11,44,11,420,46.3,7.21,135.66,"other metabolic processes","other cell component","other molecular function","GMPPA","ENSG00000144591","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars","Synthesis of GDP-mannose","",4549.5,4566.2,4524.4,4441.5,4357.7,5245,0.971226556158414,-0.042120225276615894,0.6590319140273602,0.1810935539183106,0.7585613007285,0.12000931732631336,6350]
["Q96IV0","Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase [OS=Homo sapiens]",18,12,23,12,654,74.3,6.89,58.16,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","NGLY1","ENSG00000151092","Protein processing in endoplasmic reticulum","N-glycan trimming in the ER and Calnexin/Calreticulin cycle","",2952.7,3042.5,2980.3,2981.9,2885.8,3108.2,0.9999554362236655,-6.42933717094985e-05,0.9985644407467924,6.2390339448230683E-4,0.9989744726824946,0.000445609386407201,7306]
["Q96JB2-1","Conserved oligomeric Golgi complex subunit 3 [OS=Homo sapiens]",15,10,13,10,828,94,5.57,37.33,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi","","COG3","ENSG00000136152","","COPI-mediated anterograde transport; Retrograde transport at the Trans-Golgi-Network; Intra-Golgi traffic","",786.5,795.5,811.3,801.7,813.5,883.3,0.9578947368421054,-0.06206096813225144,0.2559195615001727,0.5918965170557814,0.4962897519248507,0.3042646926214134,3769]
["Q96JJ7-1","Protein disulfide-isomerase TMX3 [OS=Homo sapiens]",43,17,88,16,454,51.8,4.91,313.97,"protein metabolism;other metabolic processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","TMX3","ENSG00000166479; ENSGGOG00000005485","","Platelet degranulation","",7629.2,7742.4,8221.5,6808.6,7237.5,6445.9,1.1513322272106186,0.20330419610179992,0.02402577397182059,1.6193226129715228,0.1603692985936408,0.7948787702636869,1095]
["Q96JQ2","Calmin [OS=Homo sapiens]",10,8,10,8,1002,111.6,4.94,25.17,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;nucleus;other cell component","cytoskeletal activity","CLMN","ENSG00000165959","","","Vitamin D receptor pathway",520.2,573.2,534.1,586.1,652.4,614.1,0.8784950879844543,-0.18689387531310805,0.03950997684183957,1.403293224873457,0.20597604902782127,0.686183276620124,1402]
["Q96K17-1","transcription factor BTF3 homolog 4 [OS=Homo sapiens]",29,4,19,2,158,17.3,6.35,49.87,"","","","Btf3l4; BTF3L4; LOC108587672; LOC110308160; LOC111143096","ENSAMEG00000009159; ENSANAG00000025045; ENSCAFG00000003782; ENSCANG00000032994; ENSCATG00000029142; ENSCCAG00000034219; ENSCGRG00001021460; ENSCGRG00015007601; ENSCJAG00000021582; ENSCJAG00000023403; ENSCPOG00000036248; ENSECAG00000024180; ENSFCAG00000024164; ENSG00000134717; ENSGGOG00000010677; ENSHGLG00000000408; ENSLCNG00005020988; ENSMFAG00000046175; ENSMLEG00000043474; ENSMMUG00000003636; ENSMNEG00000032806; ENSMODG00000000770; ENSMUSG00000028568; ENSMUSG00000114133; ENSNLEG00000016041; ENSOCUG00000001517; ENSPANG00000025278; ENSPCOG00000026062; ENSPPAG00000025800; ENSPTRG00000000735; ENSRBIG00000044688; ENSRFEG00010003696; ENSRNOG00000008512; ENSSHAG00000025846; ENSSSCG00000038762; ENSSSCG00070030088; ENSSSUG00005008763; ENSSTOG00000006129; ENSTSYG00000033616; ENSUMAG00000022798","","","",668.5,779.6,617.4,839.2,963.3,434.5,0.9233348234242289,-0.11507419620299848,0.748884562698047,0.12558512174912884,0.8275774521862754,0.08219135044283994,6614]
["Q96KG9","N-terminal kinase-like protein [OS=Homo sapiens]",35,22,48,22,808,89.6,6.3,144.42,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;kinase activity;other molecular function","SCYL1","ENSG00000142186","","","",5541.9,5432.5,5574,5291.8,5294.8,4302.1,1.1114738022795811,0.15247394407632894,0.17214387311994994,0.7641084299302563,0.414017627059465,0.38298116812622623,3039]
["Q96KM6","zinc finger protein 512B [OS=Homo sapiens]",8,5,5,5,892,97.2,9.83,17.38,"","nucleus","nucleic acid binding activity;other molecular function","ZNF512B","ENSG00000196700","","RHOV GTPase cycle","",311,294.1,294.4,364.4,357.6,324.9,0.8592033623077656,-0.21892845587589882,0.021507122895831985,1.6674176832451089,0.1512950541343946,0.8201752689183132,1039]
["Q96L91-5","Isoform 5 of E1A-binding protein p400 [OS=Homo sapiens]",5,13,17,13,3122,339.5,9.16,50.24,"","","","EP400","","","","",1239.4,1296.3,1286.4,1548.5,1447.1,2157.1,0.7417664525394454,-0.430963073540659,0.11687565918121331,0.9322759266823674,0.3486710991655053,0.4575840491629269,2450]
["Q96LT4-1","Sphingomyelin synthase-related protein 1 [OS=Homo sapiens]",3,1,1,1,415,48.3,8.07,3.67,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi","other molecular function","SAMD8","ENSG00000156671; ENSGGOG00000011029; ENSPTRG00000002656","","Sphingolipid de novo biosynthesis","",35,33.6,32.6,28.5,23.2,22,1.3731343283582087,0.4574727655992402,0.01230501274618349,1.9099179320957347,0.11560069172474953,0.9370395672014507,778]
["Q96LZ7-1","Regulator of microtubule dynamics protein 2 [OS=Homo sapiens]",3,1,1,1,410,47.4,6.54,2.41,"","other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cell component","cytoskeletal activity","RMDN2","ENSG00000115841","","","",28.6,28.1,30.8,31.9,29.7,34.7,0.9086188992731049,-0.13825278112376813,0.15340560931218786,0.8141587600168179,0.3925915961004135,0.4060590012369817,2856]
["Q96MG8-1","Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 [OS=Homo sapiens]",9,4,6,4,357,40.7,5.66,10.9,"protein metabolism;other metabolic processes","other membranes;other cell component","other molecular function","PCMTD1","ENSG00000168300; ENSGGOG00000025636; ENSPPAG00000008533; ENSPPYG00000018582; ENSPTRG00000020242","","","",739.8,685.8,712.2,769.1,745.6,702.2,0.9643195453110199,-0.05241680523133842,0.35175471124538404,0.4537600771080822,0.5556462469186324,0.25520161472400626,4627]
["Q96MW5","Conserved oligomeric Golgi complex subunit 8 [OS=Homo sapiens]",17,9,13,9,612,68.4,5.2,41.01,"transport","other membranes;ER/Golgi","","COG8","ENSG00000213380","","COPI-mediated anterograde transport; Retrograde transport at the Trans-Golgi-Network; Intra-Golgi traffic","",669.9,626.8,676.1,740.8,766.3,1032.7,0.7767540751240254,-0.3644701896367377,0.11645199651914794,0.933853061274289,0.34783311914934706,0.45862906874210524,2447]
["Q96N11","Uncharacterized protein C7orf26 [OS=Homo sapiens]",4,1,2,1,449,50,7.69,4.92,"","","","C7orf26","ENSG00000146576","","","",17.6,17.4,23.9,16.9,20.5,24.2,0.9561688311688312,-0.06466271686444057,0.7790688599465935,0.10842415442864885,0.8506445021436588,0.07025190056643417,6694]
["Q96NC0","Zinc finger matrin-type protein 2 [OS=Homo sapiens]",14,2,2,2,199,23.6,9.01,4.03,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","ZMAT2","ENSG00000146007","Spliceosome","","",134.5,126.9,121,140.3,138.7,81.7,1.0601607984474632,0.08428310019317826,0.7316298540193062,0.13570858152897552,0.8135528073980085,0.08961425192537026,6573]
["Q96ND0","Protein FAM210A [OS=Homo sapiens]",11,3,8,3,272,30.8,9.76,22.34,"","other membranes;mitochondrion;other cell component","","FAM210A","ENSG00000177150","","","",1481.8,1507.9,1492.2,1388.2,1360,1193.9,1.1369320920321655,0.18514608587992373,0.04215989531009449,1.3751004762182975,0.21428836913872085,0.6690014003811883,1438]
["Q96P16-1","Regulation of nuclear pre-mRNA domain-containing protein 1A [OS=Homo sapiens]",25,6,11,5,312,35.7,7.55,38.34,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","LOC111142439; P15RS; RPRD1A","ENSAMEG00000000830; ENSANAG00000021312; ENSBIXG00000008485; ENSBIXG00005019871; ENSBTAG00000005497; ENSCAFG00000017862; ENSCCAG00000025615; ENSCJAG00000021044; ENSDLEG00000001661; ENSG00000141425; ENSGGOG00000007369; ENSLCNG00005017687; ENSMPUG00000001133; ENSNLEG00000006228; ENSOARG00000005585; ENSPCTG00005006209; ENSPPAG00000027698; ENSPPYG00000009111; ENSPTRG00000009974; ENSRFEG00010007667; ENSSBOG00000026758; ENSSSUG00005007348; ENSSTOG00000003343; ENSTSYG00000006414; ENSTTRG00000007088; ENSUMAG00000002096; ENSVVUG00000027590","","RNA polymerase II transcribes snRNA genes; RNA polymerase II transcribes snRNA genes","",400.7,444.4,418.5,467.1,485.1,466.2,0.8908629441624365,-0.16672459915181564,0.02159598865809038,1.6656269092860911,0.15148280336082784,0.8196366663656239,1042]
["Q96PE3-1","Type I inositol 3,4-bisphosphate 4-phosphatase [OS=Homo sapiens]",32,25,69,25,977,109.9,6.96,235.14,"other metabolic processes;signal transduction","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","INPP4A","ENSG00000040933","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of IP2, IP, and Ins in the cytosol","Insulin signaling",5655.9,5693.4,5601.6,5698.8,5755.4,6536.2,0.9422191835645678,-0.08586538933904798,0.27094327438196575,0.5671216249987099,0.5072552234779169,0.2947734721093912,3904]
["Q96PU5","E3 ubiquitin-protein ligase NEDD4-like [OS=Homo sapiens]",11,8,12,5,975,111.9,5.82,32.67,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","NEDD4L","ENSG00000049759","Ubiquitin mediated proteolysis; Endocytosis; Tight junction; Aldosterone-regulated sodium reabsorption","Stimuli-sensing channels; Antigen processing: Ubiquitination & Proteasome degradation; Budding and maturation of HIV virion; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity","TGF-beta signaling pathway",409.6,427,442.3,434.4,478.7,567.9,0.863538149898717,-0.2116681794911175,0.17056478059485108,0.7681106400640044,0.4128006560820419,0.38425962113718215,3020]
["Q96PZ2","Protein FAM111A [OS=Homo sapiens]",9,4,5,4,611,70.2,8.53,22.54,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","FAM111A","ENSG00000166801","","","",214.4,222.1,237.8,183.8,233.5,332.3,0.8995464247598719,-0.15273035533110813,0.6003374234490149,0.22160458302957978,0.7182626007511621,0.14371674627761638,6109]
["Q96QC0","Serine/threonine-protein phosphatase 1 regulatory subunit 10 [OS=Homo sapiens]",20,19,31,19,940,99,9.17,61.29,"transport;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","PPP1R10","ENSG00000204569; ENSG00000206489; ENSG00000227804; ENSG00000230995; ENSG00000231737; ENSG00000235291; ENSG00000238104","","","",4399.5,4387.8,4049.9,4978.2,5265.5,4921,0.84651855954948,-0.2403863959614008,7.725522554412792E-3,2.112072135227063,0.09271895624007077,1.0328314659759654,609]
["Q96QE3-1","ATPase family AAA domain-containing protein 5 [OS=Homo sapiens]",4,4,4,4,1844,207.4,9.19,6.82,"stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ATAD5","ENSG00000176208","","","",172.9,174.9,163.6,260.8,289.2,282.7,0.6141467515311637,-0.70334466338138,3.2049538070655034E-4,3.4941782255776523,0.022524045553694003,1.6473536029924598,104]
["Q96QT6-1","PHD finger protein 12 [OS=Homo sapiens]",3,2,2,2,1004,109.6,7.74,5.82,"other biological processes","nucleus;other cell component","other molecular function","PHF12","ENSG00000109118","","","",65.3,63.1,62.2,66,84.1,52.2,0.9421651013346515,-0.08594820064834108,0.6959622398614884,0.15741432283865653,0.7862114391263708,0.10446064162338393,6470]
["Q96R06","Sperm-associated antigen 5 [OS=Homo sapiens]",22,16,29,16,1193,134.3,5,88.13,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity","SPAG5","ENSG00000076382","","","",1498.4,1605.7,1588.4,1794.8,1756.3,4725.7,0.5669461627682197,-0.8187163515981557,0.2914581681268995,0.5354237690536395,0.5205932919940148,0.2835014322097891,4092]
["Q96RP9","Elongation factor G, mitochondrial [OS=Homo sapiens]",38,27,168,1,751,83.4,7.01,461.06,"protein metabolism;other metabolic processes","mitochondrion","nucleic acid binding activity;other molecular function","GFM1","ENSG00000168827","","Mitochondrial translation elongation","",448,427.9,448.9,459.4,406.4,581,0.9156759745645562,-0.1270909251564491,0.47895892994295863,{"$f":"-LOG10(AA5379)","v":0.3197017251320966},0.6331544255657595,{"$f":"-LOG10(AC5379)","v":0.19849035318685995},5529]
["Q96RS0","Trimethylguanosine synthase [OS=Homo sapiens]",11,6,7,6,853,96.6,4.94,20.72,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","TGS1","ENSG00000137574","","Heme signaling; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); RORA activates gene expression; snRNP Assembly","",354.9,324.3,355.5,389.3,398.7,458.4,0.8301508344030809,-0.2685546038796594,0.04219444436292035,1.3747447277436033,0.21431493665641754,0.6689475597962357,1439]
["Q96RT7","gamma-tubulin complex component 6 [OS=Homo sapiens]",2,4,5,4,1819,200.4,6.32,14.98,"cell cycle OR cell proliferation;cell organization and biogenesis","cytosol;cytoskeleton","cytoskeletal activity","TUBGCP6","ENSG00000128159","","Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes","15q11.2 copy number variation syndrome",324,284,322.9,384,345.4,348.5,0.86362371277484,-0.21152523847344512,0.05340363545620641,1.272429177337961,0.23742528683054298,0.6244730286580196,1644]
["Q96S59-1","Ran-binding protein 9 [OS=Homo sapiens]",16,8,14,8,729,77.8,6.79,41.53,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","RANBP9","ENSG00000010017","","RAF/MAP kinase cascade; L1CAM interactions; MET activates RAS signaling","Brain-derived neurotrophic factor (BDNF) signaling pathway; Ciliary landscape",537.2,547.8,585.5,599.9,632.8,2635.3,0.43187693898655644,-1.2113078121418708,0.3377337518780018,0.47142553539094484,0.5483109712297457,0.2609730641714731,4502]
["Q96SB8","structural maintenance of chromosomes protein 6 [OS=Homo sapiens]",18,16,39,16,1091,126.2,6.99,104.02,"cell organization and biogenesis;DNA metabolism;stress response;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMC6","ENSG00000163029","","SUMOylation of DNA damage response and repair proteins","",2475.9,2536.1,2606,2402.4,2450.8,2713.2,1.0068196235990694,9.805240992897717E-3,0.876203842836961,0.05739484643377673,0.9204044103615043,0.03602130896137394,6958]
["Q96SK2","Transmembrane protein 209 [OS=Homo sapiens]",15,6,13,6,561,62.9,8.63,35.02,"","other membranes","","TMEM209","ENSG00000146842","","","",1384.8,1364.2,1428,1442.1,1503,2114.3,0.8255919674269677,-0.2764991607173463,0.2439466830397116,0.61270508264433,0.4871601929883202,0.31232820615476775,3660]
["Q96SU4","Oxysterol-binding protein-related protein 9 [OS=Homo sapiens]",18,12,31,12,736,83.1,6.18,87.81,"other metabolic processes;transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","OSBPL9","ENSG00000117859","","Synthesis of bile acids and bile salts","",3859.9,3836.5,4051,3944.6,3654,3240.4,1.0838084694159977,0.11610982621398998,0.23235985771121456,0.6338388981419841,0.4786691657303459,0.3199645474176999,3548]
["Q96SZ5","2-aminoethanethiol dioxygenase [OS=Homo sapiens]",22,4,12,4,270,29.7,6.04,35.36,"","cytosol","other molecular function","ADO","ENSG00000181915","Taurine and hypotaurine metabolism; Metabolic pathways","Degradation of cysteine and homocysteine","",690.9,757.4,655.9,864.8,833.8,1452,0.667872786135974,-0.5823547650754267,0.1613465210484553,0.7922403944109746,0.40166271196974107,0.3961384837710345,2936]
["Q96T66-1","Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 [OS=Homo sapiens]",4,1,1,1,252,28.3,9.22,1.77,"other metabolic processes","mitochondrion;nucleus","other molecular function","NMNAT3","ENSG00000163864","Nicotinate and nicotinamide metabolism; Metabolic pathways; Biosynthesis of cofactors","Nicotinate metabolism","NAD+ metabolism",53.1,64.1,65.2,56.9,61.1,125.5,0.7490759753593428,-0.4168160428049631,0.41719101150042126,0.37966505714344545,0.5920872044770056,0.22761432430066353,5150]
["Q99081-1","Transcription factor 12 [OS=Homo sapiens]",7,4,4,4,682,72.9,7.02,8.37,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TCF12","ENSG00000140262","","RUNX1 regulates transcription of genes involved in differentiation of HSCs; Myogenesis; NGF-stimulated transcription","",128,140.7,145.3,270.7,294.8,254.5,0.5048780487804878,-0.9859931420061208,4.5278737281249947E-4,3.34410569311466,0.02526277028921037,1.5975190268864516,131]
["Q99439","Calponin-2 [OS=Homo sapiens]",60,13,71,13,309,33.7,7.33,202.24,"cell organization and biogenesis;stress response;developmental processes;other biological processes","non-structural extracellular;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","CNN2","ENSG00000064666","","Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","Myometrial relaxation and contraction pathways; Burn wound healing",8581,8475.4,8477,9125.7,9593.1,9100.6,0.9178271278316571,-0.12370564637446685,0.009670226187598248,2.0145633676050068,0.1027320976819122,0.9882938439565453,688]
["Q99471-1","prefoldin subunit 5 [OS=Homo sapiens]",44,5,13,5,154,17.3,6.33,46.55,"developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","LOC101567244; PFDN5","ENSCJAG00000018477; ENSG00000123349; ENSGGOG00000026308; ENSMFAG00000003143; ENSMMUG00000022030; ENSNLEG00000017706; ENSPPAG00000037126; ENSPPYG00000004575; ENSPTRG00000005010","","Prefoldin mediated transfer of substrate  to CCT/TriC","Cellular proteostasis",1624.6,1644.6,1339.3,1134.8,1939.2,971.7,1.1391106607014856,0.18790790673899685,0.5833981329846449,0.2340349650596131,0.7083151086353439,0.1497734944334647,6020]
["Q99543-1","dnaJ homolog subfamily C member 2 [OS=Homo sapiens]",35,20,42,20,621,72,8.7,115.84,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;cytosol;nucleus;other cell component","translation activity;other molecular function","DNAJC2","ENSG00000105821","","Regulation of HSF1-mediated heat shock response","",5391,5405.2,4837.6,5345.8,5509,4623.6,1.0100397973950799,0.014412138891297574,0.8828898162990086,0.05409349252567257,0.9243721053329687,0.03415316864809199,6981]
["Q99567","Nuclear pore complex protein Nup88 [OS=Homo sapiens]",29,17,57,17,741,83.5,5.69,186.33,"cell cycle OR cell proliferation;other metabolic processes;transport","cytosol;nucleus","transporter activity;other molecular function","NUP88","ENSG00000108559","Nucleocytoplasmic transport; Amyotrophic lateral sclerosis","HCMV Early Events; ISG15 antiviral mechanism; tRNA processing in the nucleus; HCMV Late Events; Transcriptional regulation by small RNAs; Viral Messenger RNA Synthesis; SUMOylation of DNA damage response and repair proteins; Rev-mediated nuclear export of HIV RNA; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)","Ciliary landscape",5938.1,5936.2,5924.8,5566.2,5504.2,4704.5,1.12831777063563,0.17417343436569904,0.07187274794952232,1.1434357502107424,0.2734606531822273,0.5631051531884631,1921]
["Q99576","TSC22 domain family protein 3 [OS=Homo sapiens]",43,4,5,3,134,14.8,4.54,11.75,"stress response;other biological processes","cytosol;nucleus","","TSC22D3","ENSG00000157514","","Stimuli-sensing channels","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway",511.1,547.2,460.3,753.2,790.2,501.5,0.7426280013692602,-0.4292883807249383,0.13582752551228572,0.8670122111545193,0.37335967806291703,0.4278725866021134,2659]
["Q99607","ETS-related transcription factor Elf-4 [OS=Homo sapiens]",1,1,1,1,663,70.7,5.6,2.6,"cell cycle OR cell proliferation;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ELF4","ENSG00000102034","","","TYROBP causal network in microglia",80.3,124.5,79,95.6,118,87,0.9441117764471059,-0.0829704198558131,0.7659971808377234,0.11577282873407145,0.8407678922875688,0.07532388174264307,6659]
["Q99638","cell cycle checkpoint control protein rad9a [OS=Homo sapiens]",10,2,5,2,391,42.5,5.66,20.5,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus","other molecular function","RAD9A","ENSG00000172613","Cellular senescence","Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Activation of ATR in response to replication stress; Presynaptic phase of homologous DNA pairing and strand exchange; HDR through Single Strand Annealing (SSA)","Androgen receptor signaling pathway; miRNA regulation of DNA damage response; ATM signaling pathway; ATR signaling; DNA IR-double strand breaks and cellular response via ATM; DNA damage response",155.5,155.6,153.1,125.8,124.4,126.6,1.2319532908704887,0.3009475577316996,9.6527762877268748E-6,5.015347758881021,0.014110428377399144,1.850459801333067,5]
["Q99717","mothers against decapentaplegic homolog 5 [OS=Homo sapiens]",10,5,13,1,465,52.2,7.71,36.7,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMAD5","ENSG00000113658","TGF-beta signaling pathway; Signaling pathways regulating pluripotency of stem cells","Signaling by BMP","Differentiation of white and brown adipocyte; BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation; BMP signaling in eyelid development; Embryonic stem cell pluripotency pathways; Genotoxicity pathway; Neovascularisation processes; Osteoblast differentiation and related diseases; TGF-beta receptor signaling in skeletal dysplasias; Network map of SARS-CoV-2 signaling pathway; TGF-beta receptor signaling",1315.6,1215.5,1211.1,1294.6,1438.7,500,1.1573933751894347,0.21087929139404116,0.5946873284612838,0.2257113153059552,0.7143089044738741,0.146113935988066,6085]
["Q99732","Lipopolysaccharide-induced tumor necrosis factor-alpha factor [OS=Homo sapiens]",4,1,1,1,161,17.1,6.44,2.51,"other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","LITAF","ENSG00000189067","Lysosome","","Intracellular trafficking proteins involved in CMT neuropathy",564.4,544.1,482.6,483,545.1,748,0.8958391982433422,-0.15868830090402075,0.5021982696920159,0.29912478796818615,0.6510406444091777,0.18639189761979666,5638]
["Q99766-1","ATP synthase subunit s, mitochondrial [OS=Homo sapiens]",5,1,1,1,215,24.9,7.56,2.9,"other metabolic processes;transport","other membranes;mitochondrion;other cell component","transporter activity;other molecular function","DMAC2L","ENSG00000125375","","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",101.4,93,100.2,90.2,93.5,63.2,1.1931956257594167,0.25483059389306734,0.18526534289625451,0.73220581541742,0.4291931509441282,0.3673472171136001,3155]
["Q99832","T-complex protein 1 subunit eta [OS=Homo sapiens]",67,29,204,29,543,59.3,7.65,700.66,"transport;other biological processes","cytosol;cytoskeleton;other cell component","other molecular function","CCT7","ENSG00000135624","","Formation of tubulin folding intermediates by CCT/TriC; Association of TriC/CCT with target proteins during biosynthesis; RHOBTB1 GTPase cycle; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate  to CCT/TriC; RHOBTB2 GTPase cycle; Folding of actin by CCT/TriC","VEGFA-VEGFR2 signaling pathway; 16p11.2 proximal deletion syndrome",26103.9,25587.4,26203.3,24108.4,23910.8,21103.7,1.1269000577232728,0.17235957174740166,0.0416915683340642,1.3799517674781954,0.21264736423843353,0.6723399959915669,1433]
["Q99856","AT-rich interactive domain-containing protein 3A [OS=Homo sapiens]",21,12,15,12,593,62.9,4.91,37.81,"other biological processes","other membranes;cytosol;nucleus","nucleic acid binding activity;other molecular function","ARID3A","ENSG00000116017","","TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest","",1112.6,1153.6,1123.3,1251.8,1304.7,1370.3,0.8631710298461851,-0.21228164966130286,0.007932397706545679,2.1005955197027086,0.09427299973519083,1.0256126735941522,615]
["Q99962","Endophilin-A1 [OS=Homo sapiens]",24,8,26,3,352,39.9,5.45,63.46,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SH3GL2","ENSG00000107295","Endocytosis","Golgi Associated Vesicle Biogenesis; MHC class II antigen presentation; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; Lysosome Vesicle Biogenesis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Retrograde neurotrophin signalling","EGF/EGFR signaling pathway",252.2,267.8,276.4,273.3,259.5,487.1,0.7808608687126188,-0.35686257840161417,0.3710917798213443,0.4305186657476061,0.5626031567546579,0.2497978353466401,4821]
["Q99996-2","Isoform 2 of A-kinase anchor protein 9 [OS=Homo sapiens]",29,95,152,1,3907,452.7,4.98,440.93,"cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","AKAP9","ENSG00000127914","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Signaling by BRAF and RAF1 fusions; Phase 3 - rapid repolarisation; Phase 2 - plateau phase","G protein signaling pathways; NO/cGMP/PKG mediated neuroprotection",60.5,69,68.7,87,69.6,84.1,0.8234316576651433,-0.28027917928800883,0.07957160205084496,1.0992418980048047,0.28791526702456727,0.5407353055674553,2020]
["Q9BPZ7","Target of rapamycin complex 2 subunit MAPKAP1 [OS=Homo sapiens]",6,2,2,2,522,59.1,7.55,4.33,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","MAPKAP1","ENSG00000119487","mTOR signaling pathway","PIP3 activates AKT signaling; CD28 dependent PI3K/Akt signaling; Regulation of TP53 Degradation; Constitutive Signaling by AKT1 E17K in Cancer; VEGFR2 mediated vascular permeability","Target of rapamycin (TOR) signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Head and neck squamous cell carcinoma; Interferon type I signaling pathways",101.1,106.9,114.1,111.5,137.3,208.4,0.7045056867891514,-0.5053167428316634,0.19808341117434075,0.7031518936543372,0.4442441400040677,0.35237829223550843,3259]
["Q9BQ75","Protein CMSS1 [OS=Homo sapiens]",11,2,4,2,279,31.9,9.19,14.34,"","","","CMSS1","ENSG00000184220","","","",628.6,565.7,575,718.7,725.5,180.7,1.0888670072004434,0.12282775591967346,0.8040039317707406,0.09474182744289004,0.8680154707994597,0.06147253424406145,6770]
["Q9BQA9-1","Uncharacterized protein C17orf62 [OS=Homo sapiens]",21,5,25,5,187,20.8,6.8,67.12,"other metabolic processes;stress response","other membranes;ER/Golgi","","C17orf62; CYBC1","ENSG00000178927; ENSGGOG00000001586; ENSPPAG00000037586; ENSPTRG00000009804","","","",3481.5,3526.5,3479.6,3330.1,3147.7,2832.8,1.1264150538096365,0.17173851990406278,0.05487193776145593,1.2606497027481913,0.24116596097322993,0.6176839900837378,1663]
["Q9BQG0","Myb-binding protein 1A [OS=Homo sapiens]",42,43,162,43,1328,148.8,9.28,491.28,"other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MYBBP1A","ENSG00000132382","","B-WICH complex positively regulates rRNA expression","Energy metabolism",13197.9,13179.8,13571,19236,18750.8,21339.1,0.6733770579123114,-0.570513525785903,1.3060759669631472E-3,2.884031561902136,0.04242715218903841,1.3723561181295256,225]
["Q9BRD0","BUD13 homolog [OS=Homo sapiens]",14,7,12,7,619,70.5,9.86,32.44,"RNA metabolism OR transcription;other metabolic processes","nucleus","","BUD13","ENSG00000137656","","","",850.4,833,816,1060.8,1097,1046.7,0.7799656732719612,-0.35851746333563417,1.9740744565120287E-4,3.704636470996425,0.018263936965375212,1.7384056004028932,79]
["Q9BRJ2","39S ribosomal protein L45, mitochondrial [OS=Homo sapiens]",43,12,47,12,306,35.3,9.03,113.97,"","other membranes;mitochondrion;translational apparatus","","MRPL45","ENSG00000277936","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",5593.5,5728.9,5656.9,5012.8,5002,5541.4,1.0914812100641544,0.12628729443260128,0.059890199353639366,1.222644241298135,0.2507087440296393,0.600830518783713,1746]
["Q9BRP8","Partner of Y14 and mago [OS=Homo sapiens]",9,1,2,1,204,22.6,9.45,7.99,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","translation activity","PYM1","ENSG00000170473","Nucleocytoplasmic transport; mRNA surveillance pathway","","",67.8,68.7,140.1,146,67.2,179.7,0.7039959277169764,-0.5063610113081924,0.39841909357893984,0.3996598569017668,0.5790505378740249,0.23728353063872096,5029]
["Q9BRR6-1","ADP-dependent glucokinase [OS=Homo sapiens]",28,8,22,8,497,54.1,6.2,86.21,"other metabolic processes","non-structural extracellular;other membranes;ER/Golgi","kinase activity;other molecular function","ADPGK","ENSG00000159322; ENSPPAG00000038547; ENSPTRG00000007256","Glycolysis / Gluconeogenesis; Metabolic pathways; Carbon metabolism","Glycolysis","",2042.3,1927.8,1957.7,1895.7,1858.2,1815.7,1.064313415685148,0.08992305372665273,0.04466685696662374,1.3500146060702607,0.21881371150740808,0.6599254673229377,1492]
["Q9BRX5","DNA replication complex GINS protein PSF3 [OS=Homo sapiens]",19,3,3,3,216,24.5,5.34,11.94,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes","nucleus","","GINS3","ENSG00000181938","","Unwinding of DNA","",447.3,460.3,387.4,446.3,507.4,448.6,0.9234828496042216,-0.11484292633876302,0.2999351389112499,{"$f":"-LOG10(AA5571)","v":0.5229726514752482},0.526344761177029,{"$f":"-LOG10(AC5571)","v":0.27872969533408154},4165]
["Q9BSB4","Autophagy-related protein 101 [OS=Homo sapiens]",19,4,6,4,218,25,6.15,20.06,"cell organization and biogenesis;other metabolic processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","ATG101","ENSG00000123395","Autophagy; Autophagy; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration","Macroautophagy","Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Alzheimer's disease",526.7,487,528.4,596.5,512.2,292,1.100949525237381,0.13874832779514165,0.6346157656435603,0.19748914300309375,0.742739252376106,0.12916362382927507,6245]
["Q9BSE5","Agmatinase, mitochondrial [OS=Homo sapiens]",12,5,17,5,352,37.6,7.59,48.36,"other metabolic processes","mitochondrion","other molecular function","AGMAT","ENSG00000116771","Arginine and proline metabolism; Metabolic pathways","Agmatine biosynthesis","",2405.1,2309.9,2465.5,2128.8,2055.2,2175.5,1.1290981995439893,0.17517096514920255,0.008773280100880385,2.056838004880029,0.09819893454415732,1.00789322427113,653]
["Q9BSJ8","Extended synaptotagmin-1 [OS=Homo sapiens]",36,32,121,32,1104,122.8,5.83,371.03,"cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi","other molecular function","ESYT1","ENSG00000139641","","RAC1 GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; Glycosphingolipid metabolism; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle","",11545.2,11854,11886.7,11421.1,11325.1,11635.5,1.0262988741103554,0.037450927248095456,0.10159469235761345,0.9931289804380429,0.3284191094390963,0.4835715808994296,2261]
["Q9BT17-1","Mitochondrial ribosome-associated GTPase 1 [OS=Homo sapiens]",10,3,8,3,334,37.2,9.47,26.68,"other biological processes","other membranes;mitochondrion;translational apparatus","other molecular function","MTG1","ENSG00000148824","","","",450.5,459.6,478.5,421.3,467.8,732,0.8565788662019616,-0.2233420118701129,0.46950066673559016,0.32836378665797233,0.6278046785895406,0.20217545213064117,5466]
["Q9BT30","Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial [OS=Homo sapiens]",10,1,1,1,221,24.5,7.11,0,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","mitochondrion","other molecular function","ALKBH7","ENSG00000125652","","","",69,54.8,66.7,95,98.1,219.2,0.46204220227989334,-1.1139034635073801,0.14664952721870603,0.8337193327968835,0.38417971126936284,0.4154655741865081,2790]
["Q9BTC0","Death-inducer obliterator 1 [OS=Homo sapiens]",18,31,59,31,2240,243.7,7.88,180.8,"RNA metabolism OR transcription;other metabolic processes;signal transduction","cytoskeleton;nucleus;other cell component","other molecular function","DIDO1","ENSG00000101191","","","",4883.9,4777.5,4648.4,6515.9,6468.9,8253.1,0.6737860146247981,-0.5696376112790491,0.01742898383179663,1.7587279329765397,0.13727202890797582,0.8624179473114288,928]
["Q9BTE3-1","Mini-chromosome maintenance complex-binding protein [OS=Homo sapiens]",19,10,22,10,642,72.9,5.87,64.67,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","MCMBP","ENSG00000197771; ENSGGOG00000006006; ENSPTRG00000003000","","","",1949.6,1977.4,2323.7,2513.5,2607.7,2619,0.8075631120642878,-0.30835308225828234,0.016465185503616416,1.783433371982553,0.1335671929477607,0.8743002010776431,901]
["Q9BTU6","Phosphatidylinositol 4-kinase type 2-alpha [OS=Homo sapiens]",30,15,31,14,479,54,8.29,65.4,"cell organization and biogenesis;other metabolic processes;transport","plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","PI4K2A","ENSG00000155252","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane","Thymic stromal lymphopoietin (TSLP) signaling pathway; Wnt signaling pathway",3521,3472.7,3484.2,3044.6,3218.8,2953.2,1.1368508994640107,0.18504305395830078,0.006067194467410427,2.217012084704915,0.08511540184703036,1.0699918461204667,521]
["Q9BTZ2","dehydrogenase/reductase sdr family member 4 [OS=Homo sapiens]",41,8,10,7,278,29.5,8.56,37.38,"other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle","other molecular function","DHRS4","ENSG00000157326; ENSG00000284807","Retinol metabolism; Metabolic pathways; Peroxisome","Peroxisomal protein import; RA biosynthesis pathway","",1936.9,1929.2,1927.1,1788.5,1679.7,2416.4,0.9844679332494987,-0.022583880426724132,0.9008472379403804,0.045348848692823726,0.936999069603848,0.028260840346069536,7027]
["Q9BU61-1","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [OS=Homo sapiens]",38,5,23,5,184,20.3,8.22,88.46,"cell organization and biogenesis","other membranes;mitochondrion;nucleus","","NDUFAF3","ENSG00000178057","Thermogenesis","Complex I biogenesis","",1808.7,1905.8,1805.2,2008,1792.1,2170.4,0.9244954358931412,-0.11326189762737188,0.25935580458424207,0.586104027713982,0.49937607368446396,0.3015722695852641,3796]
["Q9BUE0","Mediator of RNA polymerase II transcription subunit 18 [OS=Homo sapiens]",15,2,3,2,208,23.6,6.54,5.4,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","MED18","ENSG00000130772; ENSG00000284944","","Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression","",175,154.1,167.6,148.7,183.5,211.9,0.9128836610917112,-0.13149708162261237,0.4583552090633026,0.33879782866517105,0.6194745234918045,0.20797654971477758,5408]
["Q9BUL5-1","PHD finger protein 23 [OS=Homo sapiens]",5,2,3,2,403,43.8,5.78,6.47,"other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","PHF23","ENSG00000040633; ENSGGOG00000005820; ENSPPAG00000042657","","","",178.4,178,184.8,250.6,258.1,1019.8,0.35407262021589797,-1.497882807797795,0.26666034184709675,0.5740415684782697,0.504013560527652,0.2975577786673622,3867]
["Q9BUR5-1","MICOS complex subunit MIC26 [OS=Homo sapiens]",32,5,14,5,198,22.3,9.13,45.62,"cell organization and biogenesis;transport","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi","","APOO","ENSG00000184831; ENSGGOG00000001200; ENSNLEG00000010026; ENSPPYG00000020191","","Cristae formation","",1706.1,1673.4,1712.5,1416.8,1550.8,1104.2,1.2505525811680338,0.3225657188507949,0.06267442425055138,1.202909646934277,0.25336690644207965,0.5962501111896487,1808]
["Q9BV23","Monoacylglycerol lipase ABHD6 [OS=Homo sapiens]",11,3,3,3,337,38.3,8.41,9.05,"other metabolic processes;other biological processes","plasma membrane;other membranes;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","ABHD6","ENSG00000163686","Retrograde endocannabinoid signaling","Arachidonate production from DAG","",121.7,141.7,155.3,136.4,143.4,1496,0.23578105642527314,-2.0844802836908807,0.37368879003830524,0.427489929973556,0.5643163980144572,0.24847732973399556,4840]
["Q9BV44","THUMP domain-containing protein 3 [OS=Homo sapiens]",9,6,15,6,507,57,6.37,44.86,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","THUMPD3","ENSG00000134077","","","",2127.5,2024.8,2064.7,1995.8,2124.5,704.2,1.2886309462120427,0.36583914631817316,0.36485877173303444,0.4378752082177819,0.560713364717567,0.2512590922804629,4756]
["Q9BV94-1","ER degradation-enhancing alpha-mannosidase-like protein 2 [OS=Homo sapiens]",5,3,7,3,578,64.7,5.31,14.41,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi","other molecular function","EDEM2","ENSG00000088298","Protein processing in endoplasmic reticulum","ER Quality Control Compartment (ERQC); Maturation of spike protein","",869.3,873.1,838.4,834.8,856.2,783.5,1.0429581733683573,0.060681301401277414,0.2171131363146597,0.6633138989943321,0.4631873652433881,0.3342432957398509,3426]
["Q9BVI4","Nucleolar complex protein 4 homolog [OS=Homo sapiens]",24,8,15,8,516,58.4,7.49,51.37,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","","NOC4L","ENSG00000184967; ENSG00000288146","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",1158.8,1130.8,1235.3,1930.9,1897.3,2223.6,0.5824548068343303,-0.7797819807176779,1.4697948217122035E-3,2.8327432870324207,0.04402758340940367,1.3562751514871774,244]
["Q9BVK2-1","Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase [OS=Homo sapiens]",5,2,4,2,526,60,9.14,10.37,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","ALG8","ENSG00000159063","N-Glycan biosynthesis; Metabolic pathways","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG8 causes CDG-1h","",209.9,211.4,255.3,167.4,203.1,220.2,1.1454206873201287,0.19587756517127844,0.25434780437919535,0.5945720070010381,0.49534455161405244,0.30509260953014744,3753]
["Q9BVQ7-1","Spermatogenesis-associated protein 5-like protein 1 [OS=Homo sapiens]",29,11,17,11,753,80.7,8.09,54.08,"","cytoskeleton;other cell component","other molecular function","SPATA5L1","ENSG00000171763","","","",388,377.5,410.2,359,392.2,674.2,0.8248211028483232,-0.2778468507056408,0.45393655480220346,0.34300484279217996,0.6169249310244153,0.2097676787954898,5378]
["Q9BW60","Elongation of very long chain fatty acids protein 1 [OS=Homo sapiens]",4,1,1,1,279,32.6,9.6,2.12,"other metabolic processes;developmental processes","other membranes;ER/Golgi","other molecular function","ELOVL1","ENSG00000066322","Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism","Synthesis of very long-chain fatty acyl-CoAs; alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism","Omega-9 fatty acid synthesis",77.1,78.8,79.7,79.3,78,98.5,0.9210320562939794,-0.11867672505117666,0.3699080124087768,0.43190626152799155,0.5620909901654365,0.25019337601785036,4810]
["Q9BW62","katanin p60 ATPase-containing subunit A-like 1 [OS=Homo sapiens]",8,3,4,2,490,55.4,6.74,11.03,"cell organization and biogenesis;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KATNAL1","ENSG00000102781","","","",80.5,98.2,82.6,92.9,85,94.5,0.9592511013215858,-0.060019578692050615,0.5890180256161306,0.22987141437107964,0.7111220266316978,0.14805586910766086,6054]
["Q9BWF3-1","RNA-binding protein 4 [OS=Homo sapiens]",46,15,44,15,364,40.3,7.08,116.4,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RBM14; RBM4","ENSCATG00000036313; ENSG00000173933; ENSGGOG00000014455; ENSMFAG00000052468; ENSMLEG00000024601; ENSMMUG00000020363; ENSMNEG00000014872; ENSNLEG00000035021; ENSPPAG00000033403; ENSPTRG00000003934; ENSRBIG00000043267; ENSRROG00000044302","","Circadian Clock","",5957.9,5772.5,5793,4341.3,4349.3,4171,1.362458792063196,0.44621259584544565,4.7036441206547725E-5,4.327565544560023,0.011089978992859913,1.9550692765103226,31]
["Q9BWL3","Uncharacterized protein C1orf43 [OS=Homo sapiens]",9,2,2,2,253,28.8,9.6,6.68,"transport","other membranes;mitochondrion;ER/Golgi","","C1orf43","ENSG00000143612","","","",144.8,160.8,153.1,240.2,253.2,247,0.6195299837925446,-0.6907539877886131,9.4372838469373871E-5,4.025152982399299,0.014995023399405515,1.8240528521969004,46]
["Q9BX10","GTP-binding protein 2 [OS=Homo sapiens]",2,1,1,1,602,65.7,8.05,1.96,"protein metabolism;other metabolic processes","non-structural extracellular;other cell component","nucleic acid binding activity;other molecular function","GTPBP2","ENSG00000172432","","Platelet degranulation","Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway",59.4,67.5,69.4,110.4,82.2,156.9,0.5616595135908441,-0.8322322827966276,0.08096731218244338,1.091690277467159,0.2905204146988113,0.5368233445833503,2037]
["Q9BXB4","Oxysterol-binding protein-related protein 11 [OS=Homo sapiens]",28,15,32,15,747,83.6,7.06,106.32,"transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","OSBPL11","ENSG00000144909","","RHOH GTPase cycle","",2608.9,2467.4,2523.9,2844.2,2722.2,2097.5,0.9916883049100328,-0.012041352926638963,0.9323179851119807,0.030435937832625604,0.9569319130997707,0.019118961718451524,7121]
["Q9BXF6","Rab11 family-interacting protein 5 [OS=Homo sapiens]",13,7,11,7,653,70.4,9.23,33.04,"cell-cell signaling;transport;other biological processes","other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB11FIP5","ENSG00000135631","Endocytosis","","",1039.5,1018.7,1063.8,1218.1,1257.4,1959.7,0.7039141414141415,-0.5065286252719423,0.14382788724674897,0.8421568990494116,0.3817131546428788,0.41826287308634347,2754]
["Q9BXL7","Caspase recruitment domain-containing protein 11 [OS=Homo sapiens]",14,13,15,13,1154,133.2,6.09,42.42,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","kinase activity;other molecular function","CARD11","ENSG00000198286","NF-kappa B signaling pathway; T cell receptor signaling pathway; B cell receptor signaling pathway","FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; Activation of NF-kappaB in B cells","B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Modulators of TCR signaling and T cell activation; T-cell receptor (TCR) signaling pathway",996.3,1025,920.4,1108,1116.3,1391.9,0.8134782368231844,-0.2978243452369546,0.08424700013237121,1.0744455545415241,0.2977569264833178,0.5261381270794562,2068]
["Q9BXS9-1","Solute carrier family 26 member 6 [OS=Homo sapiens]",3,3,5,3,759,82.9,8.37,11.45,"stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component","transporter activity;other molecular function","SLC26A6","ENSG00000225697","Mineral absorption; Chemical carcinogenesis","Multifunctional anion exchangers","Proximal tubule transport",873.5,928.5,951.5,850.8,873.7,1081.8,0.9811851904643124,-0.027402636170134095,0.8304952303217477,0.08066285743401208,0.8848527169710866,0.05312901125679079,6860]
["Q9BY12","S phase cyclin A-associated protein in the endoplasmic reticulum [OS=Homo sapiens]",5,6,9,6,1400,158.2,7.44,19.34,"","cytosol;ER/Golgi;nucleus","nucleic acid binding activity;other molecular function","SCAPER","ENSG00000140386","","","",656.7,606.4,629.8,725.9,802,707.4,0.846821455733011,-0.23987027182495888,0.0243678158249317,1.6131833964488624,0.16191305987675073,0.7907181197231145,1100]
["Q9BY43","Charged multivesicular body protein 4a [OS=Homo sapiens]",31,6,11,6,222,25.1,4.7,34.79,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","CHMP4A","ENSG00000254505; ENSG00000285302","Endocytosis; Necroptosis","HCMV Late Events; Late endosomal microautophagy; Pyroptosis; Sealing of the nuclear envelope (NE) by ESCRT-III; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","",1075.2,2007.1,1031,1582,2041.1,2224.5,0.703416786373897,-0.5075483309656434,0.1943861141026645,0.7113347619610798,0.4410953455375271,0.3554675248967982,3221]
["Q9BY50","Signal peptidase complex catalytic subunit SEC11C [OS=Homo sapiens]",33,7,57,7,192,21.5,9.2,140.87,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","SEC11C","ENSG00000166562","Protein export","SRP-dependent cotranslational protein targeting to membrane; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP); Synthesis, secretion, and deacylation of Ghrelin","",8197.5,8065.3,8497.9,7946.7,7965.9,9867.3,0.9604653237599835,-0.0581945665172043,0.6286934105356097,0.20156109155536486,0.7393596359782415,0.1311442626490555,6215]
["Q9BYD3","39S ribosomal protein L4, mitochondrial [OS=Homo sapiens]",40,8,16,8,311,34.9,9.72,64.08,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL4","ENSG00000105364","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1775,1866.3,1727.1,1558.3,1496.3,1885.4,1.0867206477732791,0.11998112907925212,0.3251502550161937,0.48791590103765325,0.5437024053794006,0.26463874564333284,4371]
["Q9BYT3-1","Serine/threonine-protein kinase 33 [OS=Homo sapiens]",20,8,10,8,514,57.8,7.03,25.81,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction","nucleus;other cell component","kinase activity;other molecular function","STK33","ENSG00000130413","","","",682.1,681.8,714.5,643.6,667.5,778.5,0.9946401225114856,-0.007753466098549482,0.934914936730263,0.029227901629317724,0.9587895710062428,0.018276698542298426,7127]
["Q9BYV9","Transcription regulator protein BACH2 [OS=Homo sapiens]",2,1,1,1,841,92.5,5.1,2.39,"transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","BACH2","ENSG00000112182","","","",76.2,68.8,84.5,90.4,78.5,180.7,0.6564645308924485,-0.6072110311994281,0.2865537530188573,0.5427938991772434,0.5185494876986453,0.28520979046325867,4039]
["Q9BZ95","Histone-lysine N-methyltransferase NSD3 [OS=Homo sapiens]",4,4,5,1,1437,161.5,8.21,15.42,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","NSD3","ENSG00000147548","Lysine degradation; Metabolic pathways","PKMTs methylate histone lysines","",194,197.7,207.4,204.1,236.1,369.5,0.7399036680251945,-0.4345906440228791,0.2392190555418087,0.6212042285839702,0.48273110904336825,0.3162947126780368,3622]
["Q9BZF1-1","Oxysterol-binding protein-related protein 8 [OS=Homo sapiens]",33,24,60,22,889,101.1,6.96,152,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","OSBPL8","ENSG00000091039; ENSPTRG00000005242","","Acyl chain remodelling of PS","",5719.7,5661.1,5787.9,5497.1,5783,5543.6,1.02050678507106,0.029285774488053865,0.2964326024176125,0.5280740332452973,0.5238457183438902,0.28079660144721047,4136]
["Q9BZF2","Oxysterol-binding protein-related protein 7 [OS=Homo sapiens]",6,4,6,4,842,95.4,8.05,24.38,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","OSBPL7","ENSG00000006025","","Synthesis of bile acids and bile salts","",369,377.2,417.8,367.7,397.5,401.4,0.9977713012172126,-3.2189210181184295E-3,0.9648108843929608,0.015557805737570327,0.97710998393074,0.01005654915137074,7217]
["Q9BZL4","Protein phosphatase 1 regulatory subunit 12C [OS=Homo sapiens]",36,18,25,1,782,84.8,5.57,76.28,"signal transduction;other biological processes","cytoskeleton;other cell component","enzyme regulator activity;other molecular function","PPP1R12C","ENSG00000125503","Vascular smooth muscle contraction; Focal adhesion; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Proteoglycans in cancer","","Focal adhesion",21.2,28.6,13.2,15.1,18.4,34.7,0.9237536656891495,-0.11441991063689373,0.8289122172819161,0.08149145927923435,0.883810269309048,0.053640956520792885,6855]
["Q9BZQ6","ER degradation-enhancing alpha-mannosidase-like protein 3 [OS=Homo sapiens]",16,11,22,11,932,104.6,4.93,67.01,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","other molecular function","EDEM3","ENSG00000116406","Protein processing in endoplasmic reticulum","ER Quality Control Compartment (ERQC)","",1554.6,1645.6,1620.8,2068,2034.8,1794.4,0.8175066133080104,-0.29069769339214185,0.016549468940228004,1.7812159378416745,0.13365753423660384,0.8740065551629049,905]
["Q9C037-1","E3 ubiquitin-protein ligase TRIM4 [OS=Homo sapiens]",22,9,14,9,500,57.4,8.1,44.58,"protein metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","TRIM4","ENSG00000146833","","Antigen processing: Ubiquitination & Proteasome degradation; Negative regulators of DDX58/IFIH1 signaling; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; TRAF6 mediated IRF7 activation; TRAF6 mediated NF-kB activation; Ovarian tumor domain proteases; TRAF3-dependent IRF activation pathway","",1105.5,1132.6,1180.5,1044.8,994.2,1105.9,1.0870297942700882,0.1203914835635896,0.07960958374277402,1.0990346468846557,0.28791016703410954,0.5407429985159866,2021]
["Q9C0C9","(E3-independent) E2 ubiquitin-conjugating enzyme [OS=Homo sapiens]",34,34,79,34,1292,141.2,5.12,264.41,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","UBE2O","ENSG00000175931","Ubiquitin mediated proteolysis","Antigen processing: Ubiquitination & Proteasome degradation","",7084.8,7174.6,7356,7722.8,7565.1,7149.7,0.963356152173138,-0.053858834738666254,0.2198775007858937,0.6578192080400526,0.46541692824908687,0.33215782450553377,3453]
["Q9C0J8","pre-mRNA 3' end processing protein WDR33 [OS=Homo sapiens]",23,22,38,22,1336,145.8,9.17,83.97,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","","WDR33","ENSG00000136709","mRNA surveillance pathway","mRNA Splicing - Major Pathway; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs","",2332.7,2314.8,2287.6,2987.3,3005.9,3473.9,0.7325474538137339,-0.44900587574256334,0.006153729906500691,2.2108615692992397,0.08518487099737414,1.0696375299490792,528]
["Q9GZM5","protein YIPF3 [OS=Homo sapiens]",13,3,4,3,350,38.2,5.76,17.57,"other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","","YIPF3","ENSG00000137207","","","",472.8,465.2,508.5,573.9,549.6,590.7,0.8438338583595847,-0.24496911884056607,7.5738338749205564E-3,2.1206842249607094,0.09165091356257342,1.0378632016978682,604]
["Q9GZS1-2","Isoform 2 of DNA-directed RNA polymerase I subunit RPA49 [OS=Homo sapiens]",32,10,21,10,419,47.2,8.94,68.24,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","POLR1E","ENSG00000137054","RNA polymerase","B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","Pyrimidine metabolism; Eukaryotic transcription initiation; Eukaryotic transcription initiation",2138.1,2030.3,2098.1,2302.3,2165.1,1466.7,1.05601523398662,0.07863064704335743,0.692610597550665,0.1595108676485786,0.7840004425426376,0.10568369217044515,6457]
["Q9GZT6","Coiled-coil domain-containing protein 90B, mitochondrial [OS=Homo sapiens]",28,8,18,8,254,29.5,7.55,45.98,"","other membranes;mitochondrion","","CCDC90B","ENSG00000137500","","","",1782.2,1716.9,1834.5,1435.1,1775.7,1504,1.1312462882837024,0.17791305859718617,0.132430162860665,0.8780130868598719,0.36873602298994307,0.4332844327178746,2625]
["Q9GZU8","Protein FAM192A [OS=Homo sapiens]",33,7,10,7,254,28.9,5.45,17.77,"other biological processes","nucleus","","PSME3IP1","ENSG00000172775","","","",1236.2,934.6,845.2,1528.8,1237.5,856.1,0.8325971731448764,-0.26430943467585566,0.42517374158302484,0.3714335650277069,0.5969256391145464,0.22407976691695083,5206]
["Q9GZY8-2","Isoform 2 of Mitochondrial fission factor [OS=Homo sapiens]",40,8,15,4,291,33,7.44,59.29,"","","","MFF","","","","",777.4,870,838.1,885.2,839.7,650.1,1.0465263157894737,0.06560858983693557,0.6571422191470464,0.18234062997341366,0.7572209490376418,0.12077737948690444,6343]
["Q9H078-2","Isoform 2 of Caseinolytic peptidase B protein homolog [OS=Homo sapiens]",32,20,53,20,677,75.4,9.01,157.62,"","","","CLPB","","","","",4961.3,4911.8,5096.8,4931.5,4727,4304.6,1.0721043321325494,0.10044530889836789,0.15652287841974805,0.8054221741222471,0.395856649954996,0.40246205499482207,2890]
["Q9H0D6-1","5'-3' exoribonuclease 2 [OS=Homo sapiens]",43,33,111,33,950,108.5,7.47,358.53,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","XRN2","ENSG00000088930","Ribosome biogenesis in eukaryotes; RNA degradation","Major pathway of rRNA processing in the nucleolus and cytosol; Association of TriC/CCT with target proteins during biosynthesis","mRNA processing",10343.6,10497.4,10283.1,10274.4,11030.1,12195,0.929091478977298,-0.10610744255344506,0.23181495072153666,0.6348585579907214,0.478085630593598,0.32049430932176165,3544]
["Q9H0H0","integrator complex subunit 2 [OS=Homo sapiens]",9,7,9,7,1204,134.2,6.05,30.57,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","","INTS2","ENSG00000108506","","RNA polymerase II transcribes snRNA genes","",657.9,690,711.7,753.6,728.6,945.9,0.8482352456653351,-0.23746366419287587,0.1559773044661981,0.8069385892234185,0.3957091698519409,0.4026238856198587,2881]
["Q9H0K6","Pseudouridylate synthase 7 homolog-like protein [OS=Homo sapiens]",9,5,10,5,701,80.6,7.56,31.67,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","PUS7L","ENSG00000129317","","","",664.8,733,722.1,896.2,977.3,1128.3,0.706209607568792,-0.5018316466338495,0.014522618025375276,1.8379550853243851,0.12546786660457196,0.9014674864794356,846]
["Q9H0U3","Magnesium transporter protein 1 [OS=Homo sapiens]",17,8,25,8,335,38,9.63,56.67,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","transporter activity","MAGT1","ENSG00000102158","","Neutrophil degranulation; Maturation of spike protein; Miscellaneous transport and binding events; Asparagine N-linked glycosylation","",2851.4,2821.1,2895.4,2494.9,2499.4,4648,{"$f":"AVERAGE(S5890:U5890)/AVERAGE(V5890:X5890)","v":0.8885743028115699},{"$f":"LOG(Y5890,2)","v":-0.17043567505911503},{"$f":"TTEST(V5890:X5890,S5890:U5890,2,2)","v":0.6437833434087523},0.19126026399592594,{"$f":"AA5890*7309/AE5890","v":0.7489117391333074},0.12556936182789222,6283]
["Q9H0U4","ras-related protein Rab-1B [OS=Homo sapiens]",83,15,110,6,201,22.2,5.73,318.85,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","RAB1B","ENSG00000174903","Legionellosis","COPI-mediated anterograde transport; COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs; COPI-dependent Golgi-to-ER retrograde traffic; RAB geranylgeranylation; Golgi Cisternae Pericentriolar Stack Reorganization","",5774.1,5622.1,5901.1,4986.7,5698.4,5384,1.0764324075399372,0.10625773114610243,0.13778484445637595,{"$f":"-LOG10(AA5891)","v":0.8607985497066393},0.37591244051200146,{"$f":"-LOG10(AC5891)","v":0.42491330143087513},2679]
["Q9H115","Beta-soluble NSF attachment protein [OS=Homo sapiens]",35,8,33,5,298,33.5,5.47,97.76,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","other membranes;other cytoplasmic organelle;other cell component","other molecular function","NAPB","ENSG00000125814","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Retrograde transport at the Trans-Golgi-Network; Intra-Golgi traffic; COPII-mediated vesicle transport","",496,500.2,523.1,523.8,508.8,368.9,1.084052800570817,0.11643502723286063,0.4764735133655612,0.32196123630350265,0.6322703175724196,0.19909720600441574,5508]
["Q9H1A4","anaphase-promoting complex subunit 1 [OS=Homo sapiens]",7,9,20,9,1944,216.4,6.3,56.12,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","ANAPC1","ENSG00000153107","Cell cycle; Oocyte meiosis; Ubiquitin mediated proteolysis; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection","Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Cyclin B; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Inactivation of APC/C via direct inhibition of the APC/C complex; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Cell cycle",1262.5,1315.3,1378.2,1327.7,1224.9,1026.8,1.1052131642174665,0.14432465133664796,0.25444420585440153,0.5944074343332748,0.4951365017544784,0.3052750560433752,3756]
["Q9H1C4","Protein unc-93 homolog B1 [OS=Homo sapiens]",12,6,36,6,597,66.6,6.96,84.38,"stress response;transport;signal transduction;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding","UNC93B1","ENSG00000110057","","Trafficking and processing of endosomal TLR; UNC93B1 deficiency - HSE","",2976,2817,3187.3,3008.8,2941.4,2004,1.1290010309019132,0.17504680345050525,0.3733061276110868,0.42793488131441026,0.5642048152831748,0.24856321161917158,4836]
["Q9H1K1","Iron-sulfur cluster assembly enzyme ISCU, mitochondrial [OS=Homo sapiens]",20,4,6,4,167,18,9.48,17.48,"cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","ISCU","ENSG00000136003","","","",814.6,954,829.3,790.5,885.1,428.7,1.234567314546405,0.3040055012961334,0.32260741404499954,0.49132565603623096,0.5426783864798392,0.2654574749369433,4345]
["Q9H246","Uncharacterized protein C1orf21 [OS=Homo sapiens]",11,1,1,1,121,13.9,5.22,4.29,"","","","C1orf21","ENSG00000116667","","","",69.2,82.5,68.6,68.1,80.8,43.2,1.14679854242582,0.19761197603535613,0.47510115740543524,0.323213911584201,0.6317108167139033,0.19948168666595859,5497]
["Q9H269","Vacuolar protein sorting-associated protein 16 homolog [OS=Homo sapiens]",18,12,37,12,839,94.6,6.77,104.51,"cell organization and biogenesis;other metabolic processes;transport","other membranes;other cytoplasmic organelle;other cell component","cytoskeletal activity","VPS16","ENSG00000215305","Salmonella infection","","Ebola virus pathway in host; Network map of SARS-CoV-2 signaling pathway",3283.1,3276.6,3298.5,3141.1,3008.9,3178,1.0568396226415095,0.07975646170194392,0.026888819707635316,1.5704282608377282,0.17030362499402643,0.7687761077734678,1154]
["Q9H2G9-1","Golgin-45 [OS=Homo sapiens]",3,1,1,1,400,44.9,8.54,2.25,"cell organization and biogenesis;transport","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","BLZF1","ENSG00000117475","","Golgi Cisternae Pericentriolar Stack Reorganization","",63.4,64.8,62.9,102.7,107.5,61.2,0.70412675018423,-0.5060929424413975,0.14293513291231447,0.8448610101550422,0.38100397026116206,0.4190704987245631,2742]
["Q9H2H8-1","peptidyl-prolyl cis-trans isomerase-like 3 [OS=Homo sapiens]",39,7,18,7,161,18.1,6.79,51.85,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","CLK1; LOC111141199; PPIL3","ENSAMEG00000005917; ENSCAFG00000011929; ENSECAG00000019985; ENSFCAG00000005373; ENSG00000240344; ENSGGOG00000022268; ENSOCUG00000010661; ENSPPAG00000039183; ENSPPYG00000013062; ENSPTRG00000012793; ENSRFEG00010017851; ENSSSCG00000016096; ENSSSCG00070023158; ENSSSUG00005004462; ENSSTOG00000028255; ENSUMAG00000021460","","mRNA Splicing - Major Pathway; mRNA Splicing - Major Pathway","mRNA Processing",1298.9,1381.8,1290.8,1325.5,1363.2,1218.6,1.0164307834054207,0.02351197431915856,0.7026418476230589,0.15326598826081733,0.7905802438849966,0.10205404260996324,6496]
["Q9H2P9-1","Diphthine methyl ester synthase [OS=Homo sapiens]",15,4,8,4,285,31.6,5.31,21.24,"protein metabolism;other metabolic processes","cytosol","other molecular function","DPH5","ENSG00000117543; ENSPPAG00000030165; ENSPTRG00000001012","","Synthesis of diphthamide-EEF2","",1246.4,1206.1,1247.9,1197.2,1096.9,675.4,1.2461357130830104,0.3174611967165294,0.20350891709488872,0.6914165566586127,0.44856654856650835,0.34817311665287565,3316]
["Q9H329","Band 4.1-like protein 4B [OS=Homo sapiens]",1,1,2,1,900,99.7,9.04,2.25,"cell organization and biogenesis;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity","EPB41L4B","ENSG00000095203","Tight junction","","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway",169.3,190.4,159.3,167.3,146,167.2,1.0801248699271593,0.1111981075841305,0.3300693048708193,0.48139486144689964,0.5449461371811201,0.2636464215417746,4427]
["Q9H3E2","Sorting nexin-25 [OS=Homo sapiens]",3,3,4,3,840,97.9,6.38,7.29,"other metabolic processes;transport;other biological processes","other membranes;other cytoplasmic organelle;other cell component","other molecular function","SNX25","ENSG00000109762","","","",443.2,418.3,390.1,407.3,419.9,337.7,1.0744269894411538,0.10356745061128816,0.3871965288359881,0.41206854473692245,0.5709137440512885,0.24342950175810038,4957]
["Q9H3P2-1","Negative elongation factor A [OS=Homo sapiens]",38,14,42,14,528,57.2,9.03,144.18,"developmental processes;other biological processes","cytosol;nucleus","other molecular function","NELFA","ENSG00000185049","","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat","Initiation of transcription and translation elongation at the HIV-1 LTR",3088.9,3043.9,3245.1,4012.5,4100.4,4799.8,0.726253998001967,-0.4614538943643643,0.010069912408492468,1.9969743070703967,0.10559682897226894,0.976349123284433,697]
["Q9H3S7","Tyrosine-protein phosphatase non-receptor type 23 [OS=Homo sapiens]",20,27,56,27,1636,178.9,6.92,172.73,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PTPN23","ENSG00000076201","","Interleukin-37 signaling","",5547.5,5488.3,5594.3,5749.2,5574.5,7359.2,0.8901241241991338,-0.1679215668078361,0.2953493165817887,0.5296640297329024,0.5234500860563273,0.28112472446040837,4124]
["Q9H3Z4","DnaJ homolog subfamily C member 5 [OS=Homo sapiens]",32,5,14,5,198,22.1,5.07,43.26,"cell-cell signaling;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","DNAJC5","ENSG00000101152","Protein processing in endoplasmic reticulum","Neutrophil degranulation; Sensory processing of sound by inner hair cells of the cochlea; GABA synthesis, release, reuptake and degradation","",1905.2,1893.3,1813.7,1614.8,1876,979.2,1.2555257270693512,0.328291591281727,0.2282298609290724,0.641627534377456,0.47430538911873477,0.3239419408104257,3517]
["Q9H488-1","GDP-fucose protein O-fucosyltransferase 1 [OS=Homo sapiens]",9,2,8,2,388,43.9,8.53,26.45,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","POFUT1","ENSG00000101346; ENSPTRG00000013375","Other types of O-glycan biosynthesis","Pre-NOTCH Processing in the Endoplasmic Reticulum","Delta-Notch signaling pathway",375.5,403.3,416.9,391.9,368.3,277,1.1528152718858462,0.20516135281131143,0.22746086964874393,0.6430933047532353,0.4735150943499486,0.3246661723346136,3511]
["Q9H490","Phosphatidylinositol glycan anchor biosynthesis class U protein [OS=Homo sapiens]",11,4,7,4,435,50,7.72,24.74,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;ER/Golgi","","PIGU","ENSG00000101464","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways","Attachment of GPI anchor to uPAR","",990.5,1038,1033.1,852,868.4,995.1,1.1274535076413184,0.17306794285693258,0.07273285225377352,1.1382693810276852,0.2754427031724511,0.5599687281514859,1930]
["Q9H4G0-1","Band 4.1-like protein 1 [OS=Homo sapiens]",39,26,63,4,881,98.4,5.62,181.92,"cell organization and biogenesis","plasma membrane;other membranes;cytosol;cytoskeleton","cytoskeletal activity;other molecular function","EPB41L1","ENSG00000088367","","Neurexins and neuroligins; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Trafficking of AMPA receptors","Splicing factor NOVA regulated synaptic proteins",5679.3,5730.3,5753.4,5075.6,4925,4842.4,1.1563026342383615,0.20951903778149156,4.1883521771095522E-4,3.377956807856419,0.024490132849994975,1.6110088589805023,125]
["Q9H4K7","Mitochondrial ribosome-associated GTPase 2 [OS=Homo sapiens]",9,2,2,2,406,43.9,9.45,8.88,"other biological processes","other membranes;mitochondrion;translational apparatus","other molecular function","MTG2","ENSG00000101181","","","",51.3,56.9,53.7,60,63.9,79.5,0.7959685349065879,-0.3292166935549343,0.08857326127661794,1.0526973642601756,0.305657208059868,0.5147653581476688,2118]
["Q9H4L7","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 [OS=Homo sapiens]",6,5,11,5,1026,117.3,5.55,27.98,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SMARCAD1","ENSG00000163104","Signaling pathways regulating pluripotency of stem cells","","",831.8,839.1,819,1003.2,946.8,655.6,0.9555956401596561,-0.06552782327644888,0.7387496400508573,0.13150271771673155,0.8189778733705014,0.08672783157646129,6593]
["Q9H583","HEAT repeat-containing protein 1 [OS=Homo sapiens]",15,31,81,31,2144,242.2,6.54,202.7,"RNA metabolism OR transcription;other metabolic processes;other biological processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity","HEATR1","ENSG00000119285","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",7399.6,7404.7,7556.4,8149,7697.9,6891.1,0.9834066320696631,-0.024140010196853204,0.7519886979174488,0.12378868662773497,0.8300038346539766,0.08091990115981161,6622]
["Q9H5X1-1","MIP18 family protein FAM96A [OS=Homo sapiens]",28,4,10,4,160,18.3,4.88,28.37,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","CIAO2A","ENSCANG00000036332; ENSCATG00000033389; ENSG00000166797; ENSGGOG00000016550; ENSMFAG00000035924; ENSMLEG00000042755; ENSMMUG00000014004; ENSPANG00000016877; ENSPPAG00000026013; ENSPTRG00000007153; ENSRBIG00000030155; ENSRROG00000031571","","","",615.2,649.7,624.8,663.9,698.2,1075.6,0.7751979324773353,-0.3673633719267742,0.2394701133766726,0.6207486801847303,0.4827046493850248,0.3163185180602472,3626]
["Q9H6A0-1","DENN domain-containing protein 2D [OS=Homo sapiens]",5,2,3,2,471,53.6,7.64,9.16,"","cytosol;nucleus","enzyme regulator activity","DENND2D","ENSG00000162777; ENSPPAG00000037282","","RAB GEFs exchange GTP for GDP on RABs","",116.5,112.3,120.9,116.3,116.6,260.3,0.7090429845904299,-0.4960550037051226,0.375522284293911,0.4253642859335332,0.5652167166194801,0.24778500211676138,4856]
["Q9H6K1","Uncharacterized protein C6orf106 [OS=Homo sapiens]",7,1,2,1,298,32.9,4.58,4.76,"other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","ILRUN","ENSG00000196821","","","",177,173,196.4,207.4,240.5,224.8,0.8122491452356175,-0.3000057745412643,0.024599992497817687,1.6090650253420224,0.16315911539614292,0.7873886579738156,1102]
["Q9H6P5","Threonine aspartase 1 [OS=Homo sapiens]",12,3,3,3,420,44.4,7.75,6.42,"protein metabolism;other metabolic processes;other biological processes","other cell component","other molecular function","TASP1","ENSG00000089123","","","",156.8,157.1,175,142.6,141.7,177.4,1.0589127138834742,0.08258367295877099,0.5300246129515322,0.27570396243536344,0.6709300131733199,0.1733227800960922,5774]
["Q9H6U8","Alpha-1,2-mannosyltransferase ALG9 [OS=Homo sapiens]",6,3,6,3,611,69.8,8.68,22.32,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","ALG9","ENSG00000086848","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG9 causes CDG-1l","",557,581.9,609.8,510.2,559.4,731.2,0.9710684140382052,-0.042355154426498814,0.8128993508151419,0.08996322327621999,0.8736187847533998,0.05867803623842682,6801]
["Q9H788","SH2 domain-containing protein 4A [OS=Homo sapiens]",22,8,14,8,454,52.7,8.06,29.96,"other biological processes","cytosol;other cell component","other molecular function","SH2D4A","ENSG00000104611","","","",1515.9,1398.8,1479.1,1698.6,1802.6,2046,0.7920752812229592,-0.33629053997936736,0.024003470039036856,1.6197259703771412,0.16036687615659997,0.7948853304905802,1094]
["Q9H7B4-1","Histone-lysine N-methyltransferase SMYD3 [OS=Homo sapiens]",7,2,9,2,428,49.1,7.25,19.06,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","SMYD3","ENSG00000185420","Lysine degradation; Metabolic pathways","PKMTs methylate histone lysines","Histone modifications",381.1,408.1,405.2,385.1,294.4,389.4,1.1174104219290861,0.1601591812800859,0.2628967116283414,0.5802148461134827,0.5014384303996731,0.29978238463601664,3832]
["Q9H7P6","Multivesicular body subunit 12B [OS=Homo sapiens]",7,1,1,1,319,35.6,8.15,4.5,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MVB12B","ENSG00000196814","Endocytosis","Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Late endosomal microautophagy","",52.3,60.8,53.7,44.7,30.3,24.9,1.6696696696696696,0.7395627056522452,0.02611641858627863,1.583086379267522,0.1675899064504921,0.7757521414626495,1139]
["Q9H832","Ubiquitin-conjugating enzyme E2 Z [OS=Homo sapiens]",21,7,11,7,354,38.2,5.62,28.13,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","enzyme regulator activity;other molecular function","UBE2Z","ENSG00000159202","Ubiquitin mediated proteolysis","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation","",1960.8,1845.2,1919.5,1933.4,1888.7,943.2,1.2014983316895054,0.26483464525101,0.37999325663077316,0.4202241103148479,0.5670417951642142,0.24638492921957028,4898]
["Q9H871-1","Protein RMD5 homolog A [OS=Homo sapiens]",19,4,10,4,391,44,6.06,36.75,"protein metabolism;other metabolic processes","nucleus;other cell component","other molecular function","LOC111148095; RMD5A; Rmnd5a; RMND5A","ENSAMEG00000009979; ENSBIXG00000016128; ENSBIXG00005012781; ENSBMUG00000001433; ENSBTAG00000021140; ENSCANG00000000502; ENSCATG00000002310; ENSCHIG00000026499; ENSCPOG00000038199; ENSCSAG00000016355; ENSDLEG00000016828; ENSECAG00000020001; ENSG00000153561; ENSHGLG00000004880; ENSLCNG00005014561; ENSMFAG00000065825; ENSMMNG00015005282; ENSMMUG00000003523; ENSMNEG00000044699; ENSMPUG00000009296; ENSMUSG00000002222; ENSNVIG00000017991; ENSOARG00000020715; ENSOCUG00000009371; ENSOGAG00000007229; ENSPANG00000005829; ENSPCOG00000015308; ENSPCTG00005006099; ENSPPYG00000012209; ENSPTRG00000050213; ENSRBIG00000033920; ENSRNOG00000028422; ENSRROG00000038497; ENSSSCG00000035478; ENSSSCG00070028877; ENSSSUG00005017842","","","Ciliary landscape",400.2,413,427.3,376.5,427.2,314.8,1.109074653553867,0.14935647883331224,0.2906520773378389,0.5366265687229501,0.5199158182237553,0.284066969135406,4086]
["Q9H8M1","Coenzyme Q-binding protein COQ10 homolog B, mitochondrial [OS=Homo sapiens]",3,1,1,1,238,27.1,9.6,2.4,"other metabolic processes","other membranes;mitochondrion","other molecular function","COQ10B","ENSG00000115520","","Respiratory electron transport","",85.2,91.6,89.9,112.2,120.4,189.9,{"$f":"AVERAGE(S6082:U6082)/AVERAGE(V6082:X6082)","v":0.6312426035502959},{"$f":"LOG(Y6082,2)","v":-0.6637335165059827},{"$f":"TTEST(V6082:X6082,S6082:U6082,2,2)","v":0.10356697058091388},0.9847787270383583,{"$f":"AA6082*7309/AE6082","v":0.3325883075465288},0.4780930228774189,2276]
["Q9H8T0-1","AKT-interacting protein [OS=Homo sapiens]",11,3,4,3,292,33.1,9.31,11.58,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","AKTIP; FTS","ENSCSAG00000005299; ENSG00000166971; ENSGGOG00000014821; ENSMNEG00000035738; ENSNLEG00000031116; ENSPANG00000018701; ENSPTRG00000008116; ENSRROG00000038050; ENSSBOG00000028267","","","",476.7,460.9,459.5,486.9,446.2,359.6,1.0807611974936182,0.11204778370994566,0.4109080422550436,0.38625535868262173,0.5871606805165424,0.2312430348468277,5115]
["Q9H936","Mitochondrial glutamate carrier 1 [OS=Homo sapiens]",7,2,6,2,323,34.4,9.29,22.94,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","SLC25A22","ENSG00000177542","","Organic anion transporters","",1296.3,1332.3,1351.9,1191.8,1113.2,1792.1,0.9715408459642185,-0.04165344335748731,0.8653469819586324,0.06280971665769411,0.9122776707248873,0.039872954972492915,6933]
["Q9H999","Pantothenate kinase 3 [OS=Homo sapiens]",13,4,9,2,370,41.1,6.55,21.39,"other metabolic processes","cytosol;nucleus","kinase activity;other molecular function","PANK3","ENSG00000120137","Pantothenate and CoA biosynthesis; Metabolic pathways; Biosynthesis of cofactors","Coenzyme A biosynthesis","",51.7,54.6,51.1,71.6,68,60.3,0.7873936968484243,-0.34484293123714105,0.015560199061362162,1.8079848513888646,0.12997656564513835,0.8861349425272048,875]
["Q9H9A7","RecQ-mediated genome instability protein 1 [OS=Homo sapiens]",7,3,3,3,625,70.1,4.96,10.08,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","nucleus;other cell component","other molecular function","RMI1","ENSG00000178966","Fanconi anemia pathway","Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function","",107,102.2,103.3,114.5,121,189,0.7361601884570083,-0.4419083640035891,0.19282933247775147,0.7148269021537305,0.4387887892527664,0.3577444768764008,3212]
["Q9H9J4-1","Ubiquitin carboxyl-terminal hydrolase 42 [OS=Homo sapiens]",2,2,2,2,1324,145.3,8.63,5.63,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","USP42","ENSG00000106346","","Ub-specific processing proteases","",59.3,47.3,41,63.8,67.5,198.3,0.44781553398058244,-1.1590235211228228,0.2449584677256586,0.6109075432541279,0.4874493440258205,0.3120705097154487,3673]
["Q9H9T3","elongator complex protein 3 [OS=Homo sapiens]",20,10,24,10,547,62.2,8.88,76.04,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","ELP3","ENSG00000134014","","HATs acetylate histones","Ethanol effects on histone modifications",2297.9,2351.6,2362.2,2721.4,2688.5,2101,0.9335365934841363,-0.09922151945959812,0.45743107643349207,0.3396743341212172,0.6191414328985914,0.20821013206021277,5400]
["Q9HA64","Ketosamine-3-kinase [OS=Homo sapiens]",28,8,20,8,309,34.4,7.33,43.08,"protein metabolism;other metabolic processes","cytosol","kinase activity;other molecular function","FN3KRP","ENSG00000141560","","Gamma carboxylation, hypusine formation and arylsulfatase activation","",2241,2302.9,2231.6,2250.9,2219.8,3886.1,0.8107768523836875,-0.3026231943262229,0.39275620842151565,0.405876941203597,0.5749359357806645,0.24038054537473383,4993]
["Q9HAF1","Chromatin modification-related protein MEAF6 [OS=Homo sapiens]",18,2,3,2,191,21.6,9.32,11.04,"protein metabolism;other metabolic processes","nucleus;other cell component","","MEAF6","ENSG00000163875","","HATs acetylate histones; Regulation of TP53 Activity through Acetylation","",30.9,33.3,29.3,31,43.9,80.8,0.6005138086062941,-0.7357306743040382,0.2382214310627625,0.6230191707557305,0.4825832704095707,0.31642773774166166,3608]
["Q9HAP2-1","MLX-interacting protein [OS=Homo sapiens]",2,1,1,1,919,101.1,8.35,0,"other biological processes","other membranes;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","MLXIP","ENSG00000175727; ENSG00000281178","Insulin resistance; Non-alcoholic fatty liver disease","","Nonalcoholic fatty liver disease",14.6,20,24.5,22.4,16.8,27.4,0.8873873873873874,-0.17236404689372964,0.5829382165473086,0.23437747205822393,0.7079919283390292,0.14997169357831278,6018]
["Q9HAW4","Claspin [OS=Homo sapiens]",1,1,1,1,1339,151,4.82,2.74,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","ER/Golgi;nucleus","nucleic acid binding activity;other molecular function","CLSPN","ENSG00000092853","","Ub-specific processing proteases; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Apoptotic cleavage of cellular proteins","",14.4,21.3,17.8,21.7,21,56.1,0.5414979757085019,-0.8849721502961687,0.2682955923238301,0.571386462047265,0.505014804093452,0.29669589070933955,3883]
["Q9HB90","ras-related GTP-binding protein C [OS=Homo sapiens]",34,9,14,5,399,44.2,5.1,41.02,"RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RRAGC","ENSG00000116954","Autophagy; mTOR signaling pathway; Shigellosis","Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Macroautophagy; mTORC1-mediated signalling; Amino acids regulate mTORC1; Energy dependent regulation of mTOR by LKB1-AMPK","Target of rapamycin (TOR) signaling",1513.3,1580.6,1521.8,1354.1,1175,810.3,1.3821944061807512,0.46696054561614103,0.0578216033460519,1.2379098698654893,0.2465683190526799,0.6080627255686957,1714]
["Q9HBH5","Retinol dehydrogenase 14 [OS=Homo sapiens]",34,9,27,9,336,36.8,8.79,85.2,"other metabolic processes","other membranes;cytosol;ER/Golgi;nucleus","other molecular function","RDH14","ENSG00000240857","","RA biosynthesis pathway","",2701.9,2619.3,2797.9,2603.7,2663.9,2761.4,1.0112218208992403,0.016099500513986644,0.6862293589782024,0.16353070544412354,0.7794328492263685,0.10822129480055606,6435]
["Q9HBR0","Putative sodium-coupled neutral amino acid transporter 10 [OS=Homo sapiens]",16,16,33,16,1119,119.7,5.73,90.23,"transport;developmental processes","other membranes;ER/Golgi","transporter activity","SLC38A10","ENSG00000157637","","","",4030.1,3985.4,3816.2,4051.9,4349.2,5987.7,0.8222853886356055,-0.28228890133054513,0.23190198701669662,0.6346955301602457,0.47813021808322587,0.3204538077953581,3545]
["Q9HC52","chromobox protein homolog 8 [OS=Homo sapiens]",22,7,17,7,389,43.4,9.91,39.61,"protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","CBX8","ENSG00000141570","","SUMOylation of DNA damage response and repair proteins; SUMOylation of RNA binding proteins; SUMOylation of chromatin organization proteins; SUMOylation of transcription cofactors; Oxidative Stress Induced Senescence; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN gene transcription","",1070.3,1058.1,993.6,1282.9,1176.7,1419.3,0.8048673593028949,-0.31317704562652526,0.02719671340493608,1.5654835752430556,0.17121514063452006,0.7664578330976564,1161]
["Q9HCC9-1","Lateral signaling target protein 2 homolog [OS=Homo sapiens]",6,3,3,3,887,96.4,5.11,10.56,"other biological processes","other membranes;cytosol;other cytoplasmic organelle","other molecular function","ZFYVE28","ENSG00000159733","","","",48.4,44.5,51,53.8,46.8,81.2,0.7915291529152916,-0.3372856074538091,0.30176379257640096,0.5203328706823842,0.5272750561656502,0.2779627733790414,4183]
["Q9HCJ1","progressive ankylosis protein homolog [OS=Homo sapiens]",5,2,5,2,492,54.2,7.88,10.25,"transport;developmental processes;other biological processes","plasma membrane;other membranes","transporter activity","ANKH","ENSG00000154122","","Miscellaneous transport and binding events","",450.5,429.2,460.5,412.9,399.6,276.7,1.2304443628351085,0.2991794247391179,0.13212201267067467,0.8790248191381306,0.3682989285316404,0.433799544608223,2622]
["Q9HCK8-1","Chromodomain-helicase-dna-binding protein 8 [OS=Homo sapiens]",5,11,13,5,2581,290.3,6.47,32.73,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CHD8","ENSG00000100888","Wnt signaling pathway","Deactivation of the beta-catenin transactivating complex","lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Malignant pleural mesothelioma",910,938.6,949.5,1070.5,1104.5,947.3,0.896166287672549,-0.1581616392320637,0.09294305935497435,1.0317830361920342,0.3140641797621394,0.5029815937471526,2163]
["Q9HD26-1","Golgi-associated PDZ and coiled-coil motif-containing protein [OS=Homo sapiens]",18,8,12,8,462,50.5,5.92,36.97,"transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","GOPC","ENSG00000047932","","RHOQ GTPase cycle; RHO GTPases regulate CFTR trafficking","",1817.9,1785,1667.3,2322.7,2081.8,2007.2,0.8219660932358034,-0.2828492120868281,0.022698419334866653,1.6440043850115833,0.15607031695064946,0.806679687650907,1063]
["Q9HDC9","Adipocyte plasma membrane-associated protein [OS=Homo sapiens]",50,18,71,18,416,46.5,6.16,226.63,"other metabolic processes","other membranes;other cell component","other molecular function","APMAP","ENSG00000101474","","","Ciliary landscape",10328.2,10250.4,10387,9063.3,9090.1,9211.9,1.131564426481712,0.17831872788327793,3.8014054460935862E-5,4.420055807426471,0.011113788962199209,1.9541378542145356,25]
["Q9NNX1","tuftelin [OS=Homo sapiens]",5,2,2,2,390,44.2,6,2.63,"developmental processes;signal transduction","non-structural extracellular;other cell component","extracellular structural activity;bone, tooth or skin structural activity","TUFT1","ENSG00000143367","","","",217.8,246.8,195.4,214.6,225.7,605.2,0.6312769010043041,-0.6636551323437636,0.3763968885414315,0.4243539752949192,0.5653688570384963,0.2476681180057459,4866]
["Q9NP80-1","Calcium-independent phospholipase A2-gamma [OS=Homo sapiens]",8,6,10,5,782,88.4,9.23,22.81,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle","other molecular function","IPLA2(GAMMA); PNPLA8","ENSG00000135241","","Acyl chain remodelling of PC; Acyl chain remodelling of PE","Eicosanoid synthesis",821.7,797.8,820.6,783.9,762.1,313.4,1.312305044638055,0.39210311266459436,0.2759094779585728,0.5592333805124513,0.5114436658379936,0.2912021957017015,3943]
["Q9NPF5","DNA methyltransferase 1-associated protein 1 [OS=Homo sapiens]",14,6,7,6,467,53,9.5,18.39,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","DMAP1","ENSG00000178028","","HATs acetylate histones","",538.9,512.1,470,591.5,574.2,645.8,0.8396356610543748,-0.25216465272879085,0.03027288878120634,1.518946134647114,0.18121584283524747,0.7418038367080235,1221]
["Q9NPI1-1","Bromodomain-containing protein 7 [OS=Homo sapiens]",30,17,35,17,651,74.1,6.39,99.61,"cell-cell signaling;cell cycle OR cell proliferation;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","BRD7","ENSG00000166164","Hepatocellular carcinoma","Regulation of TP53 Activity through Acetylation","",2946,2815.8,2744.9,3309.3,3424.7,3028.7,0.8713470658731703,-0.19868062235253603,0.03341905641975702,1.4760058164856524,0.1899377009113562,0.7213888231898828,1286]
["Q9NPR2-1","Semaphorin-4B [OS=Homo sapiens]",1,1,1,1,832,92.1,6.95,2.25,"","","","","","","","",130.8,121.9,129.7,138.9,148.4,239.4,0.7260299981013858,-0.46189893617320865,0.20903274544783673,0.6797856753561425,0.45443793470500854,0.3425254225756218,3362]
["Q9NQ25-7","Isoform 7 of SLAM family member 7 [OS=Homo sapiens]",32,4,13,1,188,21.3,6.02,48.57,"","","","SLAMF7","","","","",39.2,48.2,39.8,18.6,19.7,31.5,1.822349570200573,0.8657997290747032,0.019270987318529224,1.7150960343842552,0.14446322698577443,0.8402426881988191,975]
["Q9NQ88","Fructose-2,6-bisphosphatase TIGAR [OS=Homo sapiens]",23,5,11,5,270,30,7.69,35.58,"other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","other molecular function","TIGAR","ENSG00000078237","Fructose and mannose metabolism; Metabolic pathways; Central carbon metabolism in cancer","TP53 Regulates Metabolic Genes","Genotoxicity pathway; Metabolic reprogramming in colon cancer; p53 transcriptional gene network",996.7,932.8,1053.1,920.3,915.5,556.2,1.24690635451505,0.3183531195782967,0.1917555036214857,0.717252162408235,0.4374347615385265,0.359086707936462,3204]
["Q9NQL2-1","Ras-related GTP-binding protein D [OS=Homo sapiens]",13,5,8,1,400,45.6,4.92,24.01,"stress response;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RRAGD","ENSG00000025039; ENSGGOG00000024195; ENSNLEG00000013157; ENSPPAG00000029815; ENSPTRG00000018420","Autophagy; mTOR signaling pathway; Shigellosis","Amino acids regulate mTORC1; TP53 Regulates Metabolic Genes; Regulation of PTEN gene transcription; mTORC1-mediated signalling; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK","Target of rapamycin (TOR) signaling",49.1,58.6,54.2,43,32,65.6,1.1514935988620199,0.20350639123003056,0.5271614612138598,0.2780563468851034,0.6689276250021009,0.17462086842434246,5760]
["Q9NQS7","Inner centromere protein [OS=Homo sapiens]",17,16,29,15,918,105.4,9.44,76.56,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity","INCENP","ENSG00000149503","","SUMOylation of DNA replication proteins; Separation of Sister Chromatids; RHO GTPases Activate Formins; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",2220.6,2169.9,1957.7,2085.4,2243.2,2064.1,0.9930389350352745,-0.010077810888889187,0.887428649634073,0.051866554685116154,0.9279278970208067,0.03248576854682464,6990]
["Q9NQW7-3","Isoform 3 of Xaa-Pro aminopeptidase 1 [OS=Homo sapiens]",42,21,59,20,666,74.8,5.88,197.11,"","","","XPNPEP1","","","","",5627.4,5541.8,5582,5401.5,5392.6,5708.2,1.0150827460414609,0.02159733572367687,0.480071028603784,0.3186945021065596,0.6341657596358318,0.19779721043673906,5533]
["Q9NR28-1","Diablo homolog, mitochondrial [OS=Homo sapiens]",32,8,22,7,239,27.1,5.9,68.42,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion","","DIABLO","ENSG00000184047","Apoptosis; Apoptosis","Regulation of the apoptosome activity; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Release of apoptotic factors from the mitochondria","TNF-alpha signaling pathway; Nanomaterial induced apoptosis; Apoptosis; Complement system in neuronal development and plasticity",2667.2,2765.4,2752.7,2696.4,2651.3,2392.3,1.057532299741602,0.08070172761510912,0.21054823876274636,0.6766483871044131,0.45596950433093725,0.34106420238748386,3375]
["Q9NR34","mannosyl-oligosaccharide 1,2-alpha-mannosidase IC [OS=Homo sapiens]",1,1,1,1,630,70.9,7.46,2.08,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","MAN1C1","ENSG00000117643","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum","Intra-Golgi traffic; Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2","",121.6,128.1,158.3,139.2,127.3,129.3,1.030823648307226,0.04379753981134598,0.7495521590601539,0.12519814052906766,0.8280648020814186,0.08193567518958492,6616]
["Q9NRA0-1","Sphingosine kinase 2 [OS=Homo sapiens]",2,1,3,1,654,69.2,6.95,7.09,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","SPHK2","ENSG00000063176","Sphingolipid metabolism; Metabolic pathways; Calcium signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; VEGF signaling pathway; Apelin signaling pathway; Fc gamma R-mediated phagocytosis; Tuberculosis","Sphingolipid de novo biosynthesis","Sphingolipid pathway; S1P receptor signal transduction; Metabolism of spingolipids in ER and Golgi apparatus; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway",121.7,113.7,121.1,123.5,138.6,185.1,0.7971824686940965,-0.3270181115119399,0.1814984102243793,0.7411271746708622,0.42504706194488573,0.37156298145222194,3121]
["Q9NRB3","carbohydrate sulfotransferase 12 [OS=Homo sapiens]",18,5,8,5,414,48.4,9.32,35.01,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","CHST12","ENSG00000136213","Glycosaminoglycan biosynthesis","Chondroitin sulfate biosynthesis","Metapathway biotransformation Phase I and II",615.5,591.3,654.9,825,830.8,681.3,0.7965855119592657,-0.3280988542194037,0.03876037670611978,1.4116120107597112,0.2045484428483967,0.6892038222762056,1385]
["Q9NRG7-1","Epimerase family protein sdr39u1 [OS=Homo sapiens]",5,1,3,1,319,34.7,9.77,10.09,"","","","","","","","",133,127.5,137.6,120.2,107.4,127.8,1.1201463140123804,0.16368719006267138,0.09832665210786908,1.007328747737405,0.32314276090666144,0.490605568763452,2224]
["Q9NRP0-1","oligosaccharyltransferase complex subunit OSTC [OS=Homo sapiens]",13,2,19,2,149,16.8,9.13,58.98,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","DC2; OSTC","ENSANAG00000024765; ENSCANG00000031432; ENSCATG00000035272; ENSCCAG00000023668; ENSCJAG00000042857; ENSG00000198856; ENSGGOG00000026873; ENSMFAG00000034553; ENSMLEG00000037144; ENSMMUG00000011902; ENSNLEG00000012929; ENSOGAG00000033684; ENSPANG00000016693; ENSPPAG00000043858; ENSPTRG00000024222; ENSRBIG00000031965; ENSRROG00000031431","","","",1316.7,1445.1,1450.3,1141.9,1183.3,1490.4,1.1039155047698923,0.14262975045433698,0.32641711303936793,0.4862270806052423,0.5440781480512521,0.2643387164233286,4385]
["Q9NRR8","CDC42 small effector protein 1 [OS=Homo sapiens]",10,1,1,1,79,8.9,9.99,2.02,"transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","CDC42SE1","ENSG00000197622","","","",47.9,50,44.9,64.4,81.8,244.7,0.365310821181888,-1.452803605260191,0.2233443590287293,0.6510250119570086,0.46962713467807315,0.32824681784966453,3476]
["Q9NRX2","39S ribosomal protein L17, mitochondrial [OS=Homo sapiens]",9,2,4,2,175,20,10.11,9.19,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL17","ENSG00000158042","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",707.6,961.4,641,738.5,868.6,1117.5,0.8478308742567717,-0.23815159095470784,0.4031437903704268,0.3945400252572307,0.5826731192045579,0.23457501700580224,5057]
["Q9NS00-1","Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 [OS=Homo sapiens]",18,6,13,6,363,42.2,6.64,40.84,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","C1GALT1","ENSG00000106392","Mucin type O-glycan biosynthesis; Other types of O-glycan biosynthesis; Metabolic pathways","O-linked glycosylation of mucins; Defective C1GALT1C1 causes TNPS","Ectoderm differentiation",1090.1,1084.1,1118.5,1153.8,1181.2,3274.5,0.5869863624208931,-0.7686011096036545,0.3333247735997498,0.47713240719804206,0.5472306312310358,0.26182960097673985,4452]
["Q9NS69","Mitochondrial import receptor subunit TOM22 homolog [OS=Homo sapiens]",63,5,47,5,142,15.5,4.34,200.86,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity","TOMM22","ENSG00000100216","","Mitochondrial protein import; PINK1-PRKN Mediated Mitophagy","",3396.5,3346.4,3495.1,2740,3276,3195.1,1.1114850560736502,0.15248855144779133,0.11813401085902595,0.9276250507188774,0.3499965485888207,0.45593623832464036,2467]
["Q9NSD4","zinc finger protein 275 [OS=Homo sapiens]",3,1,1,1,429,48.4,9.09,2.04,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF275","ENSG00000063587","","","",75.1,86.9,84.1,275.1,276.2,226.4,0.3164459303073165,-1.6599690809885361,4.5715470012752066E-4,3.3399368107775174,0.02512288498670713,1.5999304898606304,133]
["Q9NSG2-1","Uncharacterized protein C1orf112 [OS=Homo sapiens]",4,2,2,2,853,96.5,6,6.63,"","","","C1orf112","ENSG00000000460","","","",66.5,63.8,74.6,67.3,76.5,696.2,0.2439285714285714,-2.0354693435422386,0.36662512309025336,0.435777778201889,0.5614211239611695,0.25071125068415995,4773]
["Q9NSY1","BMP-2-inducible protein kinase [OS=Homo sapiens]",8,6,8,6,1161,129.1,6.51,19.35,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","BMP2K","ENSG00000138756","Transcriptional misregulation in cancer","","",688,680.5,684.2,777.9,781.7,678.7,0.9170799267301075,-0.12488061965789007,0.14105339114286594,0.8506164682684147,0.37944763925771335,0.4208481448023326,2717]
["Q9NTN3","UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter [OS=Homo sapiens]",2,1,3,1,355,39.2,8.97,6.69,"transport","other membranes;ER/Golgi","transporter activity","SLC35D1","ENSG00000116704","","Formation of the active cofactor, UDP-glucuronate; Transport of nucleotide sugars; Defective SLC35D1 causes SCHBCKD","",315.3,319.9,335.3,327.3,320.9,389.7,0.9350611812313324,-0.09686733098724869,0.3795196586856179,0.42076572322683814,0.5670296781138964,0.246394209707113,4892]
["Q9NTX7","E3 ubiquitin-protein ligase rnf146 [OS=Homo sapiens]",9,3,3,3,359,38.9,5.33,4.98,"cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","RNF146","ENSG00000118518","","Degradation of AXIN; Ub-specific processing proteases; Regulation of PTEN stability and activity","",153.8,154.9,144.5,165.1,168,286.6,0.7313216072293045,-0.4514221071510944,0.23915394672531154,0.6213224476296461,0.482999778009202,0.3160530688538724,3619]
["Q9NUL5","Repressor of yield of DENV protein [OS=Homo sapiens]",4,1,3,1,291,33.1,7.25,8.25,"stress response;other biological processes","cytosol;nucleus;other cell component","translation activity;nucleic acid binding activity;other molecular function","SHFL","ENSG00000130813","","","",299.4,279.2,306.1,306.5,323.5,516.2,0.771854824637934,-0.37359857313291267,0.26753161253552993,0.5726248927509253,0.5047466587563728,0.29692654725004436,3874]
["Q9NUQ2","1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [OS=Homo sapiens]",35,12,28,12,364,42,9.1,77.29,"other metabolic processes;developmental processes","other membranes;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","AGPAT5","ENSG00000155189; ENSG00000284980","Glycerolipid metabolism; Glycerophospholipid metabolism; Metabolic pathways; Phospholipase D signaling pathway","Synthesis of PA","Triacylglyceride synthesis",2966.7,2829.4,2962,2689.9,2644.4,2252.9,1.1543257064529733,0.20705035464636465,0.055429907264245445,1.256255847993506,0.24274247585043138,0.6148542227887798,1669]
["Q9NUQ3-1","Gamma-taxilin [OS=Homo sapiens]",22,10,16,9,528,60.5,7.52,45.14,"cell cycle OR cell proliferation;other biological processes","other membranes;cytosol;nucleus","other molecular function","TXLNG","ENSG00000086712","","","",1587.7,1716.9,1454.8,1844.5,1739.6,825.1,1.0794248389730565,0.11026279109925023,0.743212402356789,0.12888705166488013,0.8225529147222549,0.08483615437166313,6604]
["Q9NUU7","ATP-dependent RNA helicase DDX19A [OS=Homo sapiens]",49,21,55,4,478,53.9,6.58,145.47,"other metabolic processes;transport","nucleus;other cell component","nucleic acid binding activity;other molecular function","DDX19A","ENSG00000168872","Nucleocytoplasmic transport; mRNA surveillance pathway","","",7487.7,7405.2,7104.5,7095.5,7217,6640.4,1.0498499014456233,0.07018307844446023,0.17364625069899878,0.7603345893662595,0.4151718830091534,0.38177206620837545,3057]
["Q9NUY8","TBC1 domain family member 23 [OS=Homo sapiens]",16,8,13,8,699,78.3,5.41,44.18,"cell organization and biogenesis;transport;developmental processes","cytosol;ER/Golgi;other cell component","","TBC1D23","ENSG00000036054","","","",667.3,667.7,749.1,707,665.3,937,0.9024812713809377,-0.14803110190827737,0.44528111759762307,0.3513657209860663,0.6126806642547115,0.21276582546205433,5312]
["Q9NV96","Cell cycle control protein 50A [OS=Homo sapiens]",24,7,26,7,361,40.7,8.59,87.23,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity","TMEM30A","ENSG00000112697","","Neutrophil degranulation","",2325.8,2273.8,2386.6,2430.2,2639.5,2131.8,0.9701034506699994,-0.04378949211285454,0.6591202772883895,0.18103532744495143,0.7585435532515886,0.12001947830005286,6351]
["Q9NVG8","TBC1 domain family member 13 [OS=Homo sapiens]",26,9,11,9,400,46.5,5.24,34.76,"transport;other biological processes","other membranes;cytosol","enzyme regulator activity;other molecular function","TBC1D13","ENSG00000107021","","TBC/RABGAPs","",1016.4,1041.6,1005.2,1000.8,1057,1085.8,0.9744242270008905,-0.037378091631283326,0.37995787685009147,0.42026454776629757,0.567336490683824,0.24615928202148124,4895]
["Q9NVH2","Integrator complex subunit 7 [OS=Homo sapiens]",13,8,13,8,962,106.8,8.02,34.41,"RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","","INTS7","ENSG00000143493","","RNA polymerase II transcribes snRNA genes","",713.2,712.8,735.7,856.6,824.4,764.6,0.8839139679424273,-0.17802213710648715,0.027778343602588736,1.5562936544120334,0.17308773520146722,0.7617337046435896,1173]
["Q9NVM6","DnaJ homolog subfamily C member 17 [OS=Homo sapiens]",2,1,1,1,304,34.7,8.53,2.12,"transport;other biological processes","nucleus;other cell component","nucleic acid binding activity","DNAJC17","ENSG00000104129","","","",65.5,121.9,63.9,119.1,137.2,193.4,{"$f":"AVERAGE(S6402:U6402)/AVERAGE(V6402:X6402)","v":0.5588169891038471},{"$f":"LOG(Y6402,2)","v":-0.83955221278836},{"$f":"TTEST(V6402:X6402,S6402:U6402,2,2)","v":0.08766918644746757},1.0571530235929758,{"$f":"AA6402*7309/AE6402","v":0.30397252549551257},0.5171656682495118,2108]
["Q9NVS2","39S ribosomal protein S18a, mitochondrial [OS=Homo sapiens]",18,3,8,3,196,22.2,10.33,26.3,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPS18A","ENSG00000096080","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",847.4,855.2,777.8,728.7,660.4,655.2,1.2133248544734136,0.27896586801168965,0.013085673617572959,1.8832039160607916,0.11970361510743524,0.9218927334908101,799]
["Q9NVS9","Pyridoxine-5'-phosphate oxidase [OS=Homo sapiens]",41,7,19,7,261,30,7.06,69.9,"other metabolic processes","cytosol","other molecular function","PNPO","ENSG00000108439","Vitamin B6 metabolism; Metabolic pathways; Biosynthesis of cofactors","Vitamins B6 activation to pyridoxal phosphate","Selenium micronutrient network; Vitamin B6-dependent and responsive disorders",2457.7,2496,2182.6,2697.9,3014.2,4712,0.6845962721002291,-0.5466746585681767,0.15848295161109222,0.8000174490263421,0.3979223268036664,0.40020169258118,2911]
["Q9NVX7-1","Kelch repeat and BTB domain-containing protein 4 [OS=Homo sapiens]",5,2,2,2,518,58.1,5.67,7.11,"","","","KBTBD4","ENSG00000123444; ENSG00000284900","","","",46.3,47.2,49.8,55.2,50.6,73.6,0.798773690078038,-0.3241412806571154,0.16556270729430522,0.7810374805959666,0.40812742921216755,0.389204216412275,2965]
["Q9NW13-1","RNA-binding protein 28 [OS=Homo sapiens]",31,21,47,20,759,85.7,9.22,121.73,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity","RBM28","ENSG00000106344","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol","",5636.4,5632.2,5414.4,9041.4,8969.1,10863.1,0.5777942480328051,-0.7913722530060393,2.869432644553934E-3,2.5422039651814847,0.05958148636092245,1.224888666775643,352]
["Q9NW82","WD repeat-containing protein 70 [OS=Homo sapiens]",26,16,25,16,654,73.2,6.33,58.75,"other biological processes","nucleus;other cell component","other molecular function","WDR70","ENSG00000082068","","","",2536,2539.5,2639,2913.7,2924.1,3248.1,0.8490628336213254,-0.2360567726760627,0.01639746322854466,1.7852233343340262,0.13346220349380056,0.8746417091173577,898]
["Q9NWS8","Required for meiotic nuclear division protein 1 homolog [OS=Homo sapiens]",10,4,4,4,449,51.6,8.69,9.4,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","","RMND1","ENSG00000155906","","","",309.2,275.2,307,272,238.5,379.1,1.002023381294964,2.9161728891467513E-3,0.9897266045432139,0.004484755438724711,0.9936691967865867,2.7581728677888917E-3,7280]
["Q9NWV4","UPF0587 protein C1orf123 [OS=Homo sapiens]",71,7,29,7,160,18,5.01,88.76,"","","other molecular function","CZIB","ENSG00000162384","","","",4194.2,4625.3,3907.6,4276.2,4756,2372.8,1.1159228408592723,0.15823727720469716,0.5917067879793689,0.22789344852749427,0.7126025561610162,0.14715262413398844,6069]
["Q9NWY4","Histone PARylation factor 1 [OS=Homo sapiens]",28,10,19,10,346,39.4,6.8,59.54,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","other molecular function","HPF1","ENSG00000056050","","","",2760,2756.9,2724.9,2934.3,2989.8,2963.4,0.9273473980309422,-0.10881819991115003,3.8798057665347406E-4,3.411190015806214,0.02382983222487598,1.6228790153147719,119]
["Q9NX14-1","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [OS=Homo sapiens]",44,5,28,5,153,17.3,5.22,75.73,"cell organization and biogenesis","other membranes;mitochondrion","","NDUFB11","ENSG00000147123","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Nonalcoholic fatty liver disease",2752.2,2961.6,3041.8,2992.6,3305.4,3821.9,0.8651864148855225,-0.20891708253610508,0.1512113827108975,0.8204155152999995,0.38998023861466125,0.40895739932746805,2834]
["Q9NX20","39S ribosomal protein L16, mitochondrial [OS=Homo sapiens]",35,8,24,8,251,28.4,10.13,68.39,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL16","ENSG00000166902","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",5009.1,4919.2,4662.7,4468.8,4933,5423.2,0.9842158516020236,-0.022953342447488794,0.804170977679737,0.09465160452455418,0.8680675935402743,0.06144645643800572,6771]
["Q9NX63","MICOS complex subunit MIC19 [OS=Homo sapiens]",52,16,78,16,227,26.1,8.28,211.32,"cell organization and biogenesis","other membranes;mitochondrion;nucleus","other molecular function","CHCHD3","ENSG00000106554","","Mitochondrial protein import; Cristae formation","",10625.1,13351.9,10066.1,11986.4,12012.6,9566.3,1.0142349390590877,0.020391879319051304,0.9083511954504159,0.04174620791330064,0.9413212657801062,0.026262129873929507,7053]
["Q9NX78","Transmembrane protein 260 [OS=Homo sapiens]",4,2,4,2,707,79.5,8.4,13.94,"","other membranes","","TMEM260","ENSG00000070269","","","",203.2,215.2,218,156,172.6,204.9,1.1928772258669165,0.2544455646192603,0.08497554704941025,1.0707060308664036,0.2990304638344437,0.5242845655175298,2077]
["Q9NXF7","DDB1- and CUL4-associated factor 16 [OS=Homo sapiens]",7,1,2,1,216,24.2,6.04,8.54,"protein metabolism;other metabolic processes","nucleus;other cell component","","DCAF16","ENSG00000163257","","Neddylation","",177,170.7,185.6,229.2,232.1,187.9,0.8214725816389402,-0.2837156718649773,0.060651809563504105,1.217156237308194,0.25130616558937163,0.5997968562200219,1764]
["Q9NXR7-1","Isoform 1 of BRISC and BRCA1-A complex member 2 [OS=Homo sapiens]",11,4,10,4,415,46.9,6.14,26.99,"","","","BABAM2","","","","",988.6,919.3,1030.4,1028.1,1062.9,648,1.0727637824023366,0.10133243632356054,0.6525717889862372,0.1853717049159495,0.7537369161979154,0.12278021352159664,6328]
["Q9NXX6","Non-structural maintenance of chromosomes element 4 homolog A [OS=Homo sapiens]",12,4,6,4,385,44.3,5.38,9.92,"DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","","NSMCE4A","ENSG00000107672","","SUMOylation of DNA damage response and repair proteins","",198.6,203.3,188.7,222.1,226.9,149.5,0.9868003341687551,-0.019169890696910222,0.9224341422063179,0.0350646308029182,0.9514636106951704,0.02160781691610369,7086]
["Q9NY35-1","Claudin domain-containing protein 1 [OS=Homo sapiens]",14,3,7,3,253,28.6,5.82,21.12,"","plasma membrane;other membranes","","CLDND1","ENSCANG00000033095; ENSG00000080822; ENSGGOG00000007565; ENSPPYG00000013614","","","",503.3,484.1,494.8,418.4,460.1,392.7,1.1659848961611075,0.22154910039552747,0.02614543440122306,1.5826041380574336,0.16748201580941224,0.7760318205916753,1141]
["Q9NYG2-1","Palmitoyltransferase ZDHHC3 [OS=Homo sapiens]",3,1,2,1,299,34.1,8.18,3.48,"protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","ZDHHC3","ENSCCAG00000029642; ENSG00000163812","","","",86.3,87,89.2,101,92.3,252.3,0.5890933572710951,-0.7634318098991846,0.30523065561114593,0.5153718504872461,0.5297864787133378,0.2758991300235382,4211]
["Q9NYH9","U3 small nucleolar RNA-associated protein 6 homolog [OS=Homo sapiens]",20,10,15,10,597,70.1,7.28,50.5,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","UTP6","ENSG00000108651","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",1104.6,1122.8,1128.3,2099.6,1986.2,1642.5,0.5858107990154147,-0.7714933063433771,4.54347055501778E-3,2.342612282145354,0.07429133397455248,1.1290618433933177,447]
["Q9NYP7-1","elongation of very long chain fatty acids protein 5 [OS=Homo sapiens]",3,1,11,1,299,35.3,9.42,23.14,"other metabolic processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","ELOVL5","ENSG00000012660; ENSGGOG00000011386; ENSPPAG00000035952; ENSPTRG00000018289","Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism","Synthesis of very long-chain fatty acyl-CoAs; alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Linoleic acid metabolism affected by coronavirus infection",2230.4,2305.6,2231.5,1949,2099,783.4,1.4007327068758542,0.48618168149656904,0.19622314202470914,0.7072497744232144,0.4430630043430952,0.35353451194181446,3237]
["Q9NYU2-1","UDP-glucose:glycoprotein glucosyltransferase 1 [OS=Homo sapiens]",46,53,322,53,1555,177.1,5.63,1048.08,"protein metabolism;other metabolic processes;stress response;other biological processes","ER/Golgi;other cell component","other molecular function","UGGT1","ENSG00000136731","Protein processing in endoplasmic reticulum","ER Quality Control Compartment (ERQC)","IL-18 signaling pathway",31255.2,31795.2,31799.6,28775.3,28188.4,27790.3,1.1191212214172783,0.16236631519326525,5.7410685505137108E-4,3.2410072674622716,0.02913990974701716,1.5355117976735484,144]
["Q9NZ09-1","Ubiquitin-associated protein 1 [OS=Homo sapiens]",25,9,16,9,502,55,5.11,48.67,"protein metabolism;other metabolic processes;transport","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","UBAP1","ENSG00000165006","","HCMV Late Events; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy","",1206.4,1197.1,1315.3,1845.5,1822.9,1944.1,0.6625924276169266,-0.593806379095862,0.000287735281653436,3.5410068823295457,0.02124300175358549,1.6727841150431226,99]
["Q9NZB2-1","Constitutive coactivator of PPAR-gamma-like protein 1 [OS=Homo sapiens]",34,34,120,34,1118,121.8,8.88,407.71,"","plasma membrane;other membranes;cytosol;nucleus","","FAM120A","ENSG00000048828; ENSRROG00000028506","","","VEGFA-VEGFR2 signaling pathway",13697.1,13545.2,14360.1,14975.1,14645.7,20396.3,0.8317635368703903,-0.26575465386715674,0.2102010779773418,0.6773650611031585,0.4557578400879238,0.34126585174015744,3371]
["Q9NZJ4-1","Sacsin [OS=Homo sapiens]",1,4,4,4,4579,520.8,7.05,13.72,"other biological processes","mitochondrion;nucleus;other cell component","other molecular function","SACS","ENSG00000151835","","","",205.7,200.8,221.9,190.3,224.6,452.3,0.7246309963099631,-0.46468157605967525,0.3890608377033846,0.40998248244552166,0.5717019828657093,0.24283030149546592,4974]
["Q9NZJ7","Mitochondrial carrier homolog 1 [OS=Homo sapiens]",6,2,9,2,389,41.5,9.32,23.47,"cell organization and biogenesis;developmental processes;other biological processes","other membranes;mitochondrion","","MTCH1","ENSG00000137409","","","IL-18 signaling pathway",707.3,730.7,742.2,698.1,695.6,1375.5,0.7873031922576917,-0.3450087669929295,0.4348543127852823,0.36165621833495404,0.6050542874828914,0.21820565725408964,5253]
["Q9NZM4","BRD4-interacting chromatin-remodeling complex-associated protein [OS=Homo sapiens]",1,1,1,1,1560,158.4,6.65,2.78,"other biological processes","nucleus","other molecular function","BICRA","ENSG00000063169","","","",22.2,19.1,19.6,23.6,20.7,14.7,1.0322033898305085,0.045727273657128864,0.8316266246808615,0.0800716150994867,0.885929019063171,0.05260107254192467,6861]
["Q9NZN8-1","CCR4-NOT transcription complex subunit 2 [OS=Homo sapiens]",16,8,13,8,540,59.7,7.66,30.49,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","Cnot2; CNOT2; LOC111142051","ENSAMEG00000011938; ENSBIXG00000020780; ENSBIXG00005028198; ENSBMUG00000006457; ENSBTAG00000003748; ENSCAFG00000000441; ENSCANG00000037683; ENSCATG00000036994; ENSCCAG00000033920; ENSCSAG00000004177; ENSDLEG00000001866; ENSFCAG00000024278; ENSG00000111596; ENSGGOG00000027402; ENSLAFG00000004789; ENSLCNG00005003598; ENSMFAG00000034373; ENSMLEG00000041145; ENSMMUG00000014853; ENSMNEG00000045426; ENSMPUG00000017494; ENSPANG00000018112; ENSPCTG00005004059; ENSPPAG00000042482; ENSPTRG00000005216; ENSRBIG00000039989; ENSRFEG00010003667; ENSRROG00000042572; ENSSBOG00000026423; ENSSSUG00005015658; ENSUMAG00000020863","RNA degradation","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","",1461.7,1389.6,1501.7,1689.7,1572,1082.8,1.0019564967199908,2.8198704804048335E-3,0.9887385994855633,0.004918511038191236,0.9933595084041212,2.8935468121631847E-3,7275]
["Q9P015","39S ribosomal protein L15, mitochondrial [OS=Homo sapiens]",40,10,20,10,296,33.4,10.01,72.38,"protein metabolism;other metabolic processes;other biological processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL15","ENSG00000137547","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",2486.8,2604.4,2362.8,2195.5,2298.5,2305.9,1.0961925910675159,0.13250128896333077,0.04963151074278007,1.304242505031023,0.22858015880212953,0.6409614699018981,1587]
["Q9P0J1","[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial [OS=Homo sapiens]",7,3,6,3,537,61,6.67,16.84,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","other molecular function","PDP1","ENSG00000164951","","Regulation of pyruvate dehydrogenase (PDH) complex","Orexin receptor pathway",388.8,386.5,442.8,384.7,304.2,905.6,0.7639385387268736,-0.38847152133934437,0.5438745502674557,0.26450126281932423,0.6807979256559057,0.1669817761866386,5839]
["Q9P0L0","vesicle-associated membrane protein-associated protein A [OS=Homo sapiens]",67,14,116,2,249,27.9,8.62,298.47,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","VAPA","ENSG00000101558","Cholesterol metabolism","Neutrophil degranulation; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; Sphingolipid de novo biosynthesis","Exercise-induced circadian regulation",16271.9,16335.1,16829.5,17705.1,19234.7,23910.2,0.8124322103533278,-0.2996806558492949,0.11229370148765741,0.9496446024728895,0.3424091214740459,0.46545467462257034,2397]
["Q9P0U4","CXXC-type zinc finger protein 1 [OS=Homo sapiens]",14,8,9,8,656,75.7,8.24,25.33,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","CXXC1","ENSG00000154832","","XBP1(S) activates chaperone genes","Male infertility",451.2,453.3,432.5,486.4,491.9,510.8,0.8978577664361025,-0.15544117543286767,6.917685132830911E-3,2.1600392093332332,0.08933102585841189,1.048997678637532,566]
["Q9P1Y6-1","PHD and RING finger domain-containing protein 1 [OS=Homo sapiens]",7,11,18,10,1649,178.6,8.95,39.76,"RNA metabolism OR transcription;other metabolic processes","","other molecular function","KIAA1542; PHRF1","ENSG00000070047; ENSG00000274780","","","",1480.5,1436.5,1465.9,1434.1,1541.9,1609.4,0.9558380948226981,-0.06516182770413548,0.2691858576887173,0.5699477605293718,0.5056487879328796,0.29615102944914135,3891]
["Q9P206","Uncharacterized protein KIAA1522 [OS=Homo sapiens]",2,1,2,1,1035,107,9.73,8.5,"other biological processes","","","KIAA1522","ENSG00000162522","","","",15.1,10.5,16.8,8.4,13,19.1,1.0469135802469136,0.06614235679121215,0.8698108591958367,0.06057517466632491,0.9156629079450339,0.038264378038905235,6943]
["Q9P275","Ubiquitin carboxyl-terminal hydrolase 36 [OS=Homo sapiens]",3,4,6,4,1121,122.6,9.67,13.86,"","","","","","","","",227.8,240.7,229.8,529.1,609.7,529.3,0.41861998681134216,-1.2562869008636353,2.8422090026157239E-4,3.5463439892708712,0.021197658775630946,1.673712103079393,98]
["Q9P287","BRCA2 and CDKN1A-interacting protein [OS=Homo sapiens]",37,10,30,10,314,36,4.61,75.8,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus","enzyme regulator activity;cytoskeletal activity","BCCIP","ENSG00000107949","","","",3484.9,3476.9,3544.2,3395.1,3431.7,2737.9,1.098413959664182,0.13542186582189678,0.23805662103510278,0.6233197350505434,0.48278464016247674,0.3162465554735958,3604]
["Q9P2E9-1","Ribosome-binding protein 1 [OS=Homo sapiens]",74,90,756,2,1410,152.4,8.6,2319.83,"","","","","","","","",86756.3,85136.8,82888.9,98845.2,102195.2,115150.4,0.8057856205809909,-0.3115320343767689,0.01591261661080307,1.7982584007307318,0.1314184348117058,0.8813437095445844,885]
["Q9P2K5-1","Myelin expression factor 2 [OS=Homo sapiens]",8,6,16,6,600,64.1,8.75,44.33,"stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","MYEF2","ENSG00000104177","","","Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Mitochondrial gene expression",1857.4,1851.4,2008.2,2748.8,2154.6,2391.6,0.7836874571624401,-0.35164968787149936,0.04325527924105997,1.363960879983161,0.2171379367945792,0.6632642930762065,1456]
["Q9P2M7-1","cingulin [OS=Homo sapiens]",18,23,34,23,1197,136.3,5.54,88.33,"","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity","CGN","ENSG00000143375","Tight junction","TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)","",2536.7,2511.7,2514.2,3284.1,3374.8,4248.9,0.6933203762445223,-0.5284059338486982,0.022281031879393516,1.6520646999817328,0.1542159678091735,0.8118706562955532,1056]
["Q9P2X0-1","Dolichol-phosphate mannosyltransferase subunit 3 [OS=Homo sapiens]",24,2,11,2,92,10.1,5.94,36.9,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi;other cell component","enzyme regulator activity","DPM3","ENSG00000179085","N-Glycan biosynthesis; Metabolic pathways","Synthesis of dolichyl-phosphate mannose; Defective DPM1 causes DPM1-CDG (CDG-1e); Defective DPM3 causes DPM3-CDG (CDG-1o); Defective DPM2 causes DPM2-CDG (CDG-1u)","",1539.6,1172.4,1026.6,984.5,1168.3,1177.9,1.1224667487314979,0.16667270808383644,0.45642393781437174,0.34063158645349983,0.6184654359446131,0.20868456668639926,5394]
["Q9UBC2-2","Isoform 2 of Epidermal growth factor receptor substrate 15-like 1 [OS=Homo sapiens]",37,29,73,2,910,99.5,5.08,234.54,"","","","EPS15L1","","","","",5992.5,5849.1,5965.6,6578.5,7071.1,6379.2,0.8890797251957182,-0.16961530126834926,0.02441564317204556,1.6123318307740344,0.16208350222023707,0.7902611878618131,1101]
["Q9UBD5-1","Origin recognition complex subunit 3 [OS=Homo sapiens]",22,13,21,12,711,82.2,7.61,48.09,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","ORC3","ENSG00000135336","Cell cycle","CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Assembly of the ORC complex at the origin of replication; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation","Cell cycle; G1 to S cell cycle control; DNA replication",1371.2,1421.3,1411.5,1364.7,1418.2,1248.2,1.042891518444097,0.060589096551530726,0.3337397829151193,0.4765920208828127,0.5469291644230061,0.26206891771098156,4460]
["Q9UBM7","7-dehydrocholesterol reductase [OS=Homo sapiens]",23,11,81,11,475,54.5,8.7,186.98,"other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","DHCR7","ENSG00000172893","Steroid biosynthesis; Metabolic pathways","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis via desmosterol; Cholesterol biosynthesis via lathosterol","Vitamin D metabolism; Cholesterol biosynthesis pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias",9946.3,9777.9,10493.1,9074,9042.4,9645.7,1.088437113907089,0.12225805605599281,0.04849065708071639,1.31434193086497,0.22733689070106228,0.6433300841698386,1559]
["Q9UBQ7","Glyoxylate reductase/hydroxypyruvate reductase [OS=Homo sapiens]",35,10,41,10,328,35.6,7.39,118.2,"other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle;other cell component","other molecular function","GRHPR","ENSG00000137106","Glycine, serine and threonine metabolism; Pyruvate metabolism; Glyoxylate and dicarboxylate metabolism; Metabolic pathways","Glyoxylate metabolism and glycine degradation","",4105.7,4050.2,4234.7,4041.3,3994,4479.8,0.9900520171632667,-0.014423768753672322,0.8127325266414576,0.09005235885400754,0.873567946650355,0.05870330967627087,6800]
["Q9UBS0","Ribosomal protein S6 kinase beta-2 [OS=Homo sapiens]",20,4,6,4,482,53.4,7.34,21.13,"protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus;other cell component","kinase activity;other molecular function","RPS6KB2","ENSG00000175634","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; ErbB signaling pathway; HIF-1 signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; TGF-beta signaling pathway; Apelin signaling pathway; Fc gamma R-mediated phagocytosis; Thermogenesis; Insulin signaling pathway; Insulin resistance; Shigellosis; Human cytomegalovirus infection; Human papillomavirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Proteoglycans in cancer; Chemical carcinogenesis; Colorectal cancer; Pancreatic cancer; Acute myeloid leukemia; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer","Constitutive Signaling by AKT1 E17K in Cancer; AKT phosphorylates targets in the nucleus","IL-5 signaling pathway; AMP-activated protein kinase (AMPK) signaling; Follicle stimulating hormone (FSH) signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Thermogenesis; Translation inhibitors in chronically activated PDGFRA cells; Head and neck squamous cell carcinoma; Cytoplasmic ribosomal proteins; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; Malignant pleural mesothelioma; ErbB signaling pathway",273.3,276.8,294.2,267,302.6,319.1,0.9500393833689659,-0.07394077406124991,0.4249611255940804,0.3716507963312406,0.5968564310082886,0.22413012233681628,5204]
["Q9UBU6","Protein FAM8A1 [OS=Homo sapiens]",13,2,4,2,413,44.1,7.21,15.08,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","","FAM8A1","ENSG00000137414","","","",163.5,167.2,179,198.5,221.7,232.1,0.7813889314732486,-0.355887275277924,0.012343614762544574,1.9085576408262965,0.11581448048708382,0.936237136614888,779]
["Q9UBV2","Protein sel-1 homolog 1 [OS=Homo sapiens]",22,13,47,13,794,88.7,5.39,129.68,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;ER/Golgi","","SEL1L","ENSG00000071537","Protein processing in endoplasmic reticulum","ABC-family proteins mediated transport; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Defective CFTR causes cystic fibrosis; ER Quality Control Compartment (ERQC); Pre-NOTCH Processing in Golgi","Genotoxicity pathway; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5",2657.3,2633.6,2716,2729.8,2845.4,1926.2,1.0673874210147438,0.09408391461520019,0.5925076837358272,0.22730601327999753,0.7127450066532524,0.14706581658677323,6076]
["Q9UDW1","cytochrome b-c1 complex subunit 9 [OS=Homo sapiens]",38,2,6,2,63,7.3,9.47,16.43,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","UQCR10","ENSG00000184076","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly",1075,1289.5,1017.5,809.2,859.4,551,1.5236979635970445,0.607576951646214,0.03746310463560636,1.4263962346959256,0.20163316036940127,0.6954380427564354,1358]
["Q9UER7-1","Death domain-associated protein 6 [OS=Homo sapiens]",7,6,13,6,740,81.3,4.87,27.33,"cell organization and biogenesis;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","DAXX","ENSG00000204209; ENSG00000206206; ENSG00000206279; ENSG00000227046; ENSG00000231617","MAPK signaling pathway; Apoptosis; Parkinson disease; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Herpes simplex virus 1 infection","HCMV Early Events; Inhibition of DNA recombination at telomere; Regulation of TP53 Degradation; SUMOylation of transcription cofactors; Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations; Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations","Androgen receptor signaling pathway; Amyotrophic lateral sclerosis (ALS); Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; p38 MAPK signaling pathway",1679.1,1711.1,1627.6,2004.1,2021.9,1567.1,0.8971411203089519,-0.1565931559452579,0.27212519765465715,0.5652312425064919,0.5080365439739181,0.2941050470164811,3915]
["Q9UEW8","STE20/SPS1-related proline-alanine-rich protein kinase [OS=Homo sapiens]",22,11,31,9,545,59.4,6.29,89.07,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","STK39","ENSG00000198648","","","",2540.2,2509.6,2530.7,2496.9,2392,1922,1.1129953456958699,0.1544475596560386,0.22082277473383694,0.6559561373234565,0.4663373766338093,0.33129977473361133,3461]
["Q9UFW8","CGG triplet repeat-binding protein 1 [OS=Homo sapiens]",25,3,3,3,167,18.8,8.95,11.39,"cell organization and biogenesis;other biological processes","nucleus","nucleic acid binding activity;other molecular function","CGGBP1","ENSG00000163320","","","",381.3,413.4,401.1,383.7,354.4,353.2,1.095757353614955,0.13192836080482578,0.06343629271786107,1.197662205564687,0.2546160700026615,0.594114189475634,1821]
["Q9UG63","ATP-binding cassette sub-family F member 2 [OS=Homo sapiens]",38,26,112,26,623,71.2,7.37,269.11,"transport","","transporter activity;other molecular function","ABCF2","ENSG00000033050","Pathogenic Escherichia coli infection","","VEGFA-VEGFR2 signaling pathway",16147.7,16045.9,16175.3,17046.7,16816.5,13743.9,1.0160018148553471,0.02290297915778624,0.8233204726847363,0.08443108528875183,0.8795161261111865,0.055756193253822604,6842]
["Q9UGP4","LIM domain-containing protein 1 [OS=Homo sapiens]",34,15,32,15,676,72.1,6.65,121.56,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","LIMD1","ENSG00000144791","Hippo signaling pathway; Hippo signaling pathway","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Malignant pleural mesothelioma",2870,2808.7,2931.7,3581.3,3726.7,2844.1,0.8481397937372563,-0.23762601982795575,0.135568883520317,0.8678399805734782,0.37321015806026253,0.4280465441069931,2655]
["Q9UGU5","HMG domain-containing protein 4 [OS=Homo sapiens]",7,3,3,3,601,65.7,9.32,9.13,"cell-cell signaling;transport;signal transduction;other biological processes","nucleus","nucleic acid binding activity;other molecular function","HMGXB4","ENSG00000100281","","","",132.9,135.8,142.6,167.2,147.2,135.5,0.9142031562569461,-0.12941329507866378,0.2549857712739473,0.5934840534076886,0.49539899049475833,0.3050448827380757,3762]
["Q9UH17-1","DNA dC->dU-editing enzyme APOBEC-3B [OS=Homo sapiens]",21,6,14,4,382,45.9,6.06,42.85,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","other molecular function","APOBEC3B","ENSG00000179750","Human immunodeficiency virus 1 infection","Formation of the Editosome","",450.6,504.2,474.8,781.6,688.1,558.5,{"$f":"AVERAGE(S6722:U6722)/AVERAGE(V6722:X6722)","v":0.7048614535055714},{"$f":"LOG(Y6722,2)","v":-0.5045883834514566},{"$f":"TTEST(V6722:X6722,S6722:U6722,2,2)","v":0.03994781317099196},1.3985069899110825,{"$f":"AA6722*7309/AE6722","v":0.2078139263108756},0.6823253522682082,1405]
["Q9UHB7-1","AF4/FMR2 family member 4 [OS=Homo sapiens]",10,9,12,9,1163,127.4,9.31,24.62,"other biological processes","nucleus;other cell component","","AFF4","ENSG00000072364","","RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex","",535.8,565.4,527.7,510.8,527.4,689.4,0.9428687196110209,-0.08487118374406953,0.601529820248442,0.22074283806922168,0.7188655095153471,0.14335235292553122,6116]
["Q9UHG3","prenylcysteine oxidase 1 [OS=Homo sapiens]",29,12,37,12,505,56.6,6.18,118.54,"protein metabolism;other metabolic processes;transport","non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle","other molecular function","PCYOX1","ENSG00000116005","Terpenoid backbone biosynthesis","","",4428.5,4656.8,4622.4,3712.2,3092.6,3968.9,1.2723298402591494,0.3474727250402896,0.02221496217773131,1.6533544218341645,0.15405043506360355,0.8123370708267192,1054]
["Q9UHJ6","Sedoheptulokinase [OS=Homo sapiens]",18,5,12,5,478,51.5,6.83,47.44,"other metabolic processes;other biological processes","cytosol;other cell component","kinase activity;other molecular function","SHPK","ENSG00000197417","Metabolic pathways","Pentose phosphate pathway","",795.7,802.7,830,811.1,678.7,3818.4,0.4574808786405937,-1.1282166506532953,0.402137276659059,0.3956256675163948,0.5821393058231457,0.23497307632790806,5049]
["Q9UHQ4","B-cell receptor-associated protein 29 [OS=Homo sapiens]",37,12,28,12,241,28.3,9.54,66.24,"transport;other biological processes","other membranes;ER/Golgi","","BCAP29","ENSG00000075790; ENSG00000283852","","","",4161.9,4225.7,4267.2,4050.9,4329.4,3711.1,1.0465951006500487,0.06570341049711899,0.35898165098842894,0.44492774941090374,0.558968233292379,0.25261287278950456,4694]
["Q9UHW5-1","GPN-loop GTPase 3 [OS=Homo sapiens]",12,2,2,2,284,32.7,4.5,4.46,"","other cell component","other molecular function","GPN3","ENSG00000111231; ENSNLEG00000029104; ENSPPAG00000031515","","","",69.9,70.7,65.7,77.3,75.2,122.8,0.7493643298220124,-0.41626078870907646,0.2145366196825665,0.6684985665623753,0.46051340771215227,0.3367577209272063,3405]
["Q9UI09","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [OS=Homo sapiens]",6,1,3,1,145,17.1,9.63,7.87,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;mitochondrion","transporter activity","NDUFA12","ENSG00000184752","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease",399.6,499.9,468.6,572.7,488.5,5215.5,0.21796485414310068,-2.197832569248436,0.3540162254421593,0.45097683272417904,0.5565722933441047,0.2544784170232931,4649]
["Q9UI32","Glutaminase liver isoform, mitochondrial [OS=Homo sapiens]",1,1,2,1,602,66.3,7.3,4.69,"other metabolic processes;other biological processes","mitochondrion","other molecular function","GLS2","ENSG00000135423","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; D-Amino acid metabolism; Metabolic pathways; Glutamatergic synapse; GABAergic synapse; Proximal tubule bicarbonate reclamation; MicroRNAs in cancer; Central carbon metabolism in cancer","TP53 Regulates Metabolic Genes; Glutamate and glutamine metabolism; Glutamate Neurotransmitter Release Cycle","p53 transcriptional gene network; Neuroinflammation and glutamatergic signaling",330.2,320.2,321.2,256.7,211.8,134,1.6126141078838172,0.6894012486311786,0.02679997939374675,1.571865539896044,0.17003563315008244,0.7694600570992643,1152]
["Q9UIA9","exportin-7 [OS=Homo sapiens]",31,26,75,26,1087,123.8,6.32,238.09,"transport","nucleus;other cell component","other molecular function","XPO7","ENSG00000130227","Nucleocytoplasmic transport","","",6367.9,6373.5,6322.1,5700,6001.3,7021.5,1.0181970645416283,0.026016811435898037,0.7906600921239668,0.10201018128311211,0.8591933709982268,0.06590908237775595,6726]
["Q9UII2-1","ATPase inhibitor, mitochondrial [OS=Homo sapiens]",24,4,10,4,106,12.2,9.35,31.07,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","mitochondrion;other cell component","enzyme regulator activity;other molecular function","ATP5IF1","ENSG00000130770; ENSG00000285390; ENSPPAG00000043083; ENSPPYG00000001644; ENSPTRG00000000428","","","Electron transport chain: OXPHOS system in mitochondria",745.5,633.1,903.1,680.2,661.7,675.3,1.131122347808844,0.1777549868260609,0.324232524993149,0.4891434215771479,0.5432864569406065,0.26497112093585645,4362]
["Q9UJ04","testis-specific Y-encoded-like protein 4 [OS=Homo sapiens]",2,1,2,1,414,45.1,8.57,4.23,"cell organization and biogenesis","nucleus;other cell component","other molecular function","TSPYL4","ENSG00000187189","","","",305.3,258,282.5,228.9,231,79.7,1.567457375833951,0.6484262120805341,0.12071986629493212,{"$f":"-LOG10(AA6787)","v":0.9182212542414572},0.3527954829067009,{"$f":"-LOG10(AC6787)","v":0.4524769840879867},2501]
["Q9UJ70","N-acetyl-D-glucosamine kinase [OS=Homo sapiens]",53,12,63,12,344,37.4,6.24,220.03,"other metabolic processes","cytosol","kinase activity;other molecular function","NAGK","ENSG00000124357","Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars","Synthesis of UDP-N-acetyl-glucosamine","",5944.7,5920.6,6103,6324.2,6202.2,5875.8,0.9764212974535653,-0.03442433172697137,0.3766508061494298,0.42406109870564485,0.5655178188467918,0.2475537063796993,4868]
["Q9UJF2","ras GTPase-activating protein nGAP [OS=Homo sapiens]",6,6,7,5,1139,128.5,8.24,17.53,"signal transduction;other biological processes","cytosol","enzyme regulator activity","RASAL2","ENSG00000075391","Ras signaling pathway","Regulation of RAS by GAPs; RND1 GTPase cycle; RND3 GTPase cycle","Ras signaling",245.5,254.3,231.5,258.2,279.6,347.2,0.8263276836158192,-0.2752140931698217,0.1373147073948606,0.8622829442027655,0.3756112261785315,0.4252614361223006,2672]
["Q9UJQ1-1","Lysosome-associated membrane glycoprotein 5 [OS=Homo sapiens]",9,2,5,2,280,31.5,6.46,17.09,"other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","","LAMP5","ENSG00000125869","","","",460.3,427.4,456.9,462.5,462.6,243.1,1.151001540832049,0.20288976479009835,0.4707281888034825,0.3272297938853638,0.6287559086192714,0.20151792071345065,5472]
["Q9UJX4","Anaphase-promoting complex subunit 5 [OS=Homo sapiens]",17,8,16,8,755,85,6.87,43.29,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","ANAPC5","ENSG00000089053","Cell cycle; Oocyte meiosis; Ubiquitin mediated proteolysis; IL-17 signaling pathway; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection","Separation of Sister Chromatids; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Inactivation of APC/C via direct inhibition of the APC/C complex; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Cell cycle",699.4,741.5,680.2,610.4,655.3,485.9,1.2109499885818682,0.27613928393000836,0.0839410087369856,1.0760258160838543,0.2969626490119205,0.527298171383483,2066]
["Q9UK23","N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [OS=Homo sapiens]",6,3,4,3,515,56,6.6,12.23,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport","other membranes;ER/Golgi","other molecular function","NAGPA","ENSG00000103174","Lysosome","","",333.4,357.1,371.3,318.8,369.4,440.7,0.9405616086455841,-0.0884056486653064,0.578575010963452,0.2376403277482554,0.7057417815640639,0.15135417055569247,5992]
["Q9UK45","U6 snRNA-associated Sm-like protein LSm7 [OS=Homo sapiens]",54,5,11,5,103,11.6,5.27,20.11,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","LSM7","ENSG00000130332","RNA degradation; Spliceosome","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease","mRNA processing",1191.2,1378,1088,1203.1,1268.4,913.7,1.0803497577691128,0.11149845323166102,0.5474366181923569,0.26166615587184827,0.6833841575350874,0.16533509339625724,5855]
["Q9UK97","F-box only protein 9 [OS=Homo sapiens]",9,3,3,3,447,52.3,6.15,9.57,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;other cell component","other molecular function","FBXO9","ENSG00000112146","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",235.5,268.3,259.8,282.5,265.3,548.2,0.6967153284671533,-0.5213587904439513,0.295268684661558,0.529782610602992,0.5234341053095628,0.2811379835203775,4123]
["Q9UKG9-1","peroxisomal carnitine O-octanoyltransferase [OS=Homo sapiens]",8,3,3,3,612,70.1,7.08,9.46,"other metabolic processes;transport","cytosol;other cytoplasmic organelle;other cell component","other molecular function","CROT","ENSG00000005469","Peroxisome","Peroxisomal protein import; Beta-oxidation of pristanoyl-CoA","",104.6,109.3,124.6,123.8,123.7,96.6,0.9837256611450159,-0.02367205827462217,0.8720977114727676,0.05943485316826639,0.9174096391989721,0.03743670105935447,6948]
["Q9UKK3","Poly [ADP-ribose] polymerase 4 [OS=Homo sapiens]",19,24,55,24,1724,192.5,5.66,167.84,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","PARP4","ENSG00000102699","Base excision repair; Apoptosis","Maturation of nucleoprotein; Nicotinamide salvaging; Maturation of nucleoprotein","NAD+ biosynthetic pathways; 16p11.2 proximal deletion syndrome",3806.3,3820.3,3879.1,4340.3,4259.5,5710.1,0.8040377640654374,-0.3146648313557286,0.11828049580832926,0.9270868636659557,0.3498632714945684,0.45610164718406215,2471]
["Q9UKM9-1","RNA-binding protein Raly [OS=Homo sapiens]",74,19,91,1,306,32.4,9.17,296.76,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","RALY","ENSG00000125970","","","",13057,13093.7,12992.1,17710.5,16283.3,9766.3,0.8944860729294493,-0.16086907507192977,0.5632450934656802,0.24930258280885698,0.694342787677628,0.15842607126984776,5929]
["Q9UKQ2-1","Disintegrin and metalloproteinase domain-containing protein 28 [OS=Homo sapiens]",9,8,14,8,775,87.1,6.95,29.09,"protein metabolism;other biological processes","non-structural extracellular;plasma membrane;other membranes;mitochondrion","other molecular function","ADAM28","ENSG00000042980","","","",1468,1441.4,1447.5,1444.9,1472.7,1416.4,1.0052838024919242,7.602847322132034E-3,0.6954468046503863,0.157736083975804,0.7859936129874244,0.10458098303894779,6467]
["Q9UKV5","E3 ubiquitin-protein ligase AMFR [OS=Homo sapiens]",20,6,8,6,643,72.9,6.39,27.33,"cell-cell signaling;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","AMFR","ENSG00000159461","Protein processing in endoplasmic reticulum","ER Quality Control Compartment (ERQC); N-glycan trimming in the ER and Calnexin/Calreticulin cycle","Sterol regulatory element-binding proteins (SREBP) signaling",439.3,407.8,434.9,377.8,432.2,465,1.0054901960784313,0.007899014872520588,0.9359229567666009,0.02875990001002692,0.9591504333997596,0.018113272629370975,7132]
["Q9UL15-1","BAG family molecular chaperone regulator 5 [OS=Homo sapiens]",25,8,17,8,447,51.2,6.05,44.99,"cell organization and biogenesis;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","BAG5","ENSG00000166170","","Regulation of HSF1-mediated heat shock response","",962,898.2,933,932.6,886.5,876.3,1.0362840394746606,0.05141949161219895,0.26703358656967596,0.5734341111278582,0.5043277737048479,0.2972871142627967,3870]
["Q9UL26","Ras-related protein Rab-22A [OS=Homo sapiens]",26,4,7,4,194,21.8,8.15,16.74,"cell organization and biogenesis;transport","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","RAB22A","ENSG00000124209","Endocytosis","RAB geranylgeranylation","",1006.2,1018.1,1073.5,716.9,816.9,261.7,1.7253132832080202,0.7868583509304956,0.0652022370795313,1.1857375034302127,0.2588610270582804,0.5869333300502544,1841]
["Q9ULC3","Ras-related protein Rab-23 [OS=Homo sapiens]",27,6,13,6,237,26.6,6.6,31.71,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","RAB23","ENSG00000112210","","RAB geranylgeranylation","Genes related to primary cilium development (based on CRISPR); Ciliopathies",1501.6,1444.8,1524.5,1206.6,1309.9,1080.4,1.2429870165976256,0.3138112270516648,0.014440180890188944,1.840427366384189,0.12519962292573072,0.9023969791249583,843]
["Q9ULH1-1","Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 [OS=Homo sapiens]",14,14,26,14,1129,125.4,7.31,81.99,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","ASAP1","ENSG00000153317","Endocytosis; Fc gamma R-mediated phagocytosis","VxPx cargo-targeting to cilium","EGF/EGFR signaling pathway; CCL18 signaling pathway",1874.3,1875.6,1864.2,1860.9,1884.6,1952.6,0.9852582439760621,-0.021426178975282758,0.3695407280147696,0.43233768994217137,0.5622342175395402,0.25008272678906684,4804]
["Q9ULJ3","Zinc finger and BTB domain-containing protein 21 [OS=Homo sapiens]",2,3,4,3,1066,118.8,8.29,9.48,"other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","ZBTB21","ENSG00000173276","","","",423.8,392.6,373,592.5,636.5,524.7,0.6782231852654388,-0.5601679907131559,0.006231060729258647,2.205438015997141,0.08544619675450553,1.0683072631397403,533]
["Q9ULN7-5","Isoform 2 of Paraneoplastic antigen-like protein 8B [OS=Homo sapiens]",2,1,1,1,635,68.6,5.45,0,"","","","PNMA8B","ENSG00000204851","","","",33.8,35.2,27.9,38.5,34.3,36.4,0.8873626373626375,-0.17240428550477108,0.1823708609001366,0.7390445517599294,0.42559023701120635,0.3710083432618623,3132]
["Q9ULQ1-1","Two pore calcium channel protein 1 [OS=Homo sapiens]",3,2,2,2,816,94.1,8.27,6.27,"transport;signal transduction;other biological processes","other membranes;other cytoplasmic organelle","transporter activity;other molecular function","TPCN1","ENSG00000186815; ENSGGOG00000010443","Calcium signaling pathway","Stimuli-sensing channels","",111.7,122.2,98.5,95.7,92.7,85.3,1.2144683960540739,0.2803249474053882,0.05994056052468886,1.2222792001351,0.2507759341012884,0.600714143234058,1747]
["Q9ULU8-3","Isoform 3 of Calcium-dependent secretion activator 1 [OS=Homo sapiens]",4,3,5,1,1314,148.7,5.81,6.79,"","","","CADPS","","","","",37.6,40.8,47.8,40.1,37.4,55.4,0.9495861550037622,-0.07462919429362552,0.7432839079472836,0.12884526954515907,0.8225075069169865,0.08486012961173213,6605]
["Q9ULZ3","apoptosis-associated speck-like protein containing a CARD [OS=Homo sapiens]",47,9,36,9,195,21.6,6.34,109.68,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function","PYCARD","ENSG00000103490","Necroptosis; NOD-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Legionellosis; Yersinia infection; Influenza A; Lipid and atherosclerosis","Neutrophil degranulation; The AIM2 inflammasome; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; CLEC7A/inflammasome pathway","Nucleotide-binding oligomerization domain (NOD) pathway; Nanomaterial-induced inflammasome activation; TYROBP causal network in microglia; Acute viral myocarditis; Cytosolic DNA-sensing pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Prostaglandin signaling",3746,3673.6,3720.5,3538.5,3974.9,3412.1,1.0196421216420302,0.028062877755676893,0.698502413340589,0.15583208905060075,0.787984895679328,0.10348210711195445,6479]
["Q9UM13","Anaphase-promoting complex subunit 10 [OS=Homo sapiens]",11,2,3,2,185,21.2,9.06,7.44,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","","ANAPC10","ENSG00000164162","Cell cycle; Oocyte meiosis; Ubiquitin mediated proteolysis; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection","Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; Senescence-Associated Secretory Phenotype (SASP); APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Cell cycle",255.7,301,274,285.7,268.4,187.7,1.119843623618226,0.16329728658507708,0.4191980595016386,0.37758073640047735,0.5934376558004022,0.22662489956372708,5163]
["Q9UMS4","Pre-mRNA-processing factor 19 [OS=Homo sapiens]",51,15,72,15,504,55.1,6.61,239.65,"cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","PRPF19","ENSG00000110107","Spliceosome; Ubiquitin mediated proteolysis","mRNA Splicing - Major Pathway; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of TC-NER Pre-Incision Complex","",8693.3,9011.2,8753.5,9516.5,9443,6134,1.0543766313985694,0.07639030074407277,0.7053821757764507,0.15157551866871857,0.7922001110556359,0.10116510104956675,6508]
["Q9UNA1-1","Rho GTPase-activating protein 26 [OS=Homo sapiens]",6,4,5,4,814,92.2,6.64,11.44,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","ARHGAP26","ENSG00000145819","","RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOB GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOD GTPase cycle; RHOQ GTPase cycle","",489,535,541.4,482.9,418.3,989.1,0.8281225202348834,-0.2720838654974108,0.5822820370746848,0.2348666073154202,0.7076653490154425,0.15017206919594597,6014]
["Q9UNF1","Melanoma-associated antigen D2 [OS=Homo sapiens]",41,19,58,18,606,64.9,9.32,192.7,"transport;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","","MAGED2","ENSG00000102316","","Platelet degranulation","",6576.5,6534.5,6695.9,8736.3,8331.5,8860,0.7639252076921297,-0.3884966971677001,2.56225775133204E-4,3.5913771843685782,0.020356023809223783,1.6913070498301608,92]
["Q9UNM6","26S proteasome non-ATPase regulatory subunit 13 [OS=Homo sapiens]",61,21,115,21,376,42.9,5.81,329.62,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","PSMD13","ENSG00000185627","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection","Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease",17848.7,17468.8,18145.9,16496.8,15674.4,9014.6,1.2981027441496829,0.37640457641021796,0.16022900776146082,0.795258856726769,0.3998340108325425,0.3981202665243947,2929]
["Q9UNS1","Protein timeless homolog [OS=Homo sapiens]",7,6,12,6,1208,138.6,5.4,27.19,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity","TIMELESS","ENSG00000111602","","Processing of DNA double-strand break ends","",367.8,392.5,380.1,524.2,513.7,737.1,0.6424788732394368,-0.6382790802288162,0.04444517516759668,1.3521753778168217,0.2190490797707108,0.6594585669612308,1483]
["Q9UNZ2","NSFL1 cofactor p47 [OS=Homo sapiens]",61,22,122,1,370,40.5,5.1,384.24,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","NSFL1C","ENSG00000088833","Protein processing in endoplasmic reticulum","RHOH GTPase cycle","",13699.3,13630.9,13927.3,14706.7,15005.6,17377.1,0.8761525948514952,-0.1907459366323592,0.08400168262394624,1.075712014569355,0.2970335260272971,0.5271945293126704,2067]
["Q9UPN9-2","Isoform Beta of E3 ubiquitin-protein ligase TRIM33 [OS=Homo sapiens]",7,7,8,1,1110,120.5,6.67,20.82,"","","","TRIM33","","","","",55,50,75.3,81.2,86.9,63.8,0.7774902975420439,-0.36310342321366207,0.17342911523329305,0.7608779914981343,0.415060053451257,0.38188906233456366,3054]
["Q9UPQ3-1","Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 [OS=Homo sapiens]",4,3,8,2,857,94.4,7.94,10.84,"transport","nucleus;other cell component","enzyme regulator activity;other molecular function","AGAP1","ENSG00000157985","Endocytosis","","",214.6,200.7,228.3,184.4,181.9,233.8,1.0724879186802199,0.10096139620192644,0.48101612549848993,0.31784036417164946,0.6348405311066202,0.19733535369723218,5538]
["Q9UPT6","C-Jun-amino-terminal kinase-interacting protein 3 [OS=Homo sapiens]",4,7,12,4,1336,147.4,5.4,32.57,"cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","MAPK8IP3","ENSG00000138834","MAPK signaling pathway","","MAPK signaling pathway",722.3,749.1,754,244,246.7,379.3,2.557931034482759,1.354977367600713,5.8898000029446607E-4,3.229899452087636,0.02928472668130784,1.533358824951839,147]
["Q9UPY8","Microtubule-associated protein RP/EB family member 3 [OS=Homo sapiens]",19,5,11,1,281,32,5.54,26.85,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MAPRE3","ENSG00000084764","","","",20,18.9,27.1,22.4,24.6,13,1.1,0.13750352374993502,0.6722057827573331,0.1724977557630045,0.7681601104085909,0.11454824895322867,6396]
["Q9UPY8-2","Isoform 2 of Microtubule-associated protein RP/EB family member 3 [OS=Homo sapiens]",19,5,11,1,266,30.4,5.3,28.17,"","","","MAPRE3","","","","",186.4,210.5,193.2,194.9,218.3,448.5,0.6848090982940697,-0.5462262255423754,0.3275146248464981,0.48476930224221065,0.5439228341293013,0.26446270892118273,4401]
["Q9UQ90","Paraplegin [OS=Homo sapiens]",11,7,10,7,795,88.2,8.69,29.27,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes","other membranes;mitochondrion;other cell component","other molecular function","SPG7","ENSG00000197912","","Processing of SMDT1","",761.9,754.4,788.6,704.2,703.1,870,1.0121196153339482,0.017379802138320927,0.8783624221097621,0.05632625237880035,0.9214799688819078,0.03551410102939668,6967]
["Q9UQL6-1","histone deacetylase 5 [OS=Homo sapiens]",5,4,6,4,1122,121.9,6.24,18.79,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","HDAC5","ENSG00000108840","Apelin signaling pathway; Neutrophil extracellular trap formation; Alcoholism; Viral carcinogenesis; MicroRNAs in cancer","Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Regulation of PTEN gene transcription","MicroRNAs in cardiomyocyte hypertrophy; Cell differentiation - expanded index; Cell differentiation - index; Neural crest differentiation; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; VEGFA-VEGFR2 signaling pathway; Ethanol effects on histone modifications; Rett syndrome causing genes",247.4,230.3,227.5,279.3,268.1,372,0.7670219708505547,-0.38266019149662234,0.10011421365779787,0.9995042594344612,0.3260850212231928,0.48666915013461204,2244]
["Q9Y222-1","Cyclin-D-binding Myb-like transcription factor 1 [OS=Homo sapiens]",3,2,2,2,760,84.4,4.61,4.62,"cell cycle OR cell proliferation;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","DMTF1","ENSG00000135164","","","",88.4,86,95.3,97.5,83.5,79.9,1.0337293982368725,0.0478585774181516,0.6530753123103137,0.1850367332198766,0.7539610579175615,0.12265108485737479,6331]
["Q9Y248","Dna replication complex gins protein psf2 [OS=Homo sapiens]",16,3,4,3,185,21.4,5.44,9.5,"DNA metabolism;other metabolic processes;stress response","nucleus","","GINS2","ENSG00000131153","","Unwinding of DNA","",337.4,305,392.6,346.6,381.8,455,0.8745986141625823,-0.19330703247596412,0.29313531844578394,0.5329318523836754,0.5218037122552934,0.28249283553427545,4106]
["Q9Y259-1","Choline/ethanolamine kinase [OS=Homo sapiens]",8,3,3,3,395,45.2,5.49,5.95,"other metabolic processes","cytosol","kinase activity;other molecular function","CHKB","ENSG00000100288","Glycerophospholipid metabolism; Metabolic pathways; Choline metabolism in cancer","Synthesis of PC; Synthesis of PE","Fatty acid beta-oxidation; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids",182.4,200.6,195.4,180.1,175.5,597.2,0.6070528967254407,-0.7201058609129964,0.4228057563356517,0.37385910857418664,0.5956606154697915,0.22500111410225615,5188]
["Q9Y281-1","Cofilin-2 [OS=Homo sapiens]",33,5,42,1,166,18.7,7.88,107.36,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity","CFL2; CFL2b; LOC101358143; LOC111160529","ENSAMEG00000015508; ENSANAG00000001737; ENSBIXG00000015466; ENSBIXG00005004635; ENSBTAG00000015053; ENSCAFG00000032562; ENSCANG00000033619; ENSCCAG00000037328; ENSCHIG00000015758; ENSCJAG00000041665; ENSCPOG00000033162; ENSECAG00000000511; ENSFCAG00000008480; ENSG00000165410; ENSGGOG00000038032; ENSHGLG00000001467; ENSLCNG00005006126; ENSMFAG00000001352; ENSMLEG00000005793; ENSMMNG00015019505; ENSMMUG00000039560; ENSMNEG00000039241; ENSMPUG00000016306; ENSNLEG00000003417; ENSPANG00000021779; ENSPCOG00000013026; ENSPCTG00005008413; ENSPPAG00000007558; ENSPPYG00000005737; ENSPTRG00000006254; ENSRROG00000036826; ENSSBOG00000014011; ENSSSCG00000001959; ENSSSCG00015060726; ENSSSCG00025071059; ENSSSCG00030060165; ENSSSCG00035044355; ENSSSCG00040010975; ENSSSCG00045008975; ENSSSCG00050005802; ENSSSCG00055017925; ENSSSCG00060075576; ENSSSCG00065063654; ENSSSCG00070007061; ENSSSUG00005010833; ENSVVUG00000019333","Axon guidance; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Pertussis; Human immunodeficiency virus 1 infection","","Actin cytoskeleton regulation; G13 signaling pathway; G13 signaling pathway; Leptin signaling pathway; Microtubule cytoskeleton regulation; Microtubule cytoskeleton regulation; Leptin signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; G13 signaling pathway",63.5,66.7,63.2,63.6,55.9,53,1.121159420289855,0.16499143292394727,0.10646290483976485,0.9728016882790843,0.33569343031658383,0.47405715802268855,2318]
["Q9Y2C4","Nuclease EXOG, mitochondrial [OS=Homo sapiens]",7,3,6,3,368,41.1,8.27,11.83,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes","other membranes;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","EXOG","ENSG00000157036","","","",764.8,737,783.9,743.2,738,671.8,1.0616349280074315,0.08628774156506595,0.17309156954585708,0.7617240839956337,0.4147955022330064,0.38216596145844656,3050]
["Q9Y2D4","Exocyst complex component 6B [OS=Homo sapiens]",9,7,9,6,811,94.1,6.46,28.88,"cell organization and biogenesis;transport","other membranes;other cell component","","EXOC6B","ENSG00000144036","","","Ciliary landscape",597.3,622.4,627.7,602.3,531.1,718.3,0.9976778095803855,-3.3541085507734106E-3,0.9805819670194418,0.00851609772655313,0.9878805784900206,0.005295552616334858,7255]
["Q9Y2H0-1","Isoform 2 of Disks large-associated protein 4 [OS=Homo sapiens]",3,2,2,2,989,107.5,7.3,6.2,"","","","DLGAP4","","","","",114.5,140.9,108.6,168.6,167.9,195.8,0.6838249107646065,-0.5483011158394272,0.01429321195498466,1.8448701660599633,0.12422007869082387,0.9058081999739026,841]
["Q9Y2H6","Fibronectin type-III domain-containing protein 3a [OS=Homo sapiens]",11,9,18,9,1198,131.8,6.71,49.03,"cell adhesion;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","","FNDC3A","ENSG00000102531","","","",1415.2,1422.4,1433.4,1463.7,1450.1,825.3,{"$f":"AVERAGE(S7042:U7042)/AVERAGE(V7042:X7042)","v":1.1422534834585862},{"$f":"LOG(Y7042,2)","v":0.19188284224937247},{"$f":"TTEST(V7042:X7042,S7042:U7042,2,2)","v":0.44731771264308456},0.34938390453056734,{"$f":"AA7042*7309/AE7042","v":0.6130592840255588},0.21249752632947103,5333]
["Q9Y2K7","Lysine-specific demethylase 2A [OS=Homo sapiens]",18,21,32,21,1162,132.7,7.58,78.47,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus","nucleic acid binding activity;other molecular function","KDM2A","ENSG00000173120","","HDMs demethylate histones","",3039.9,3009.5,3030.8,3333.4,3320.5,2496.9,0.9922848275560608,-0.011173800564106223,0.936343996353509,0.028564569774629952,0.9591784540081004,0.018100585341322774,7135]
["Q9Y2R0","Cytochrome c oxidase assembly factor 3 homolog, mitochondrial [OS=Homo sapiens]",27,3,7,3,106,11.7,9.6,19.06,"cell organization and biogenesis;other biological processes","other membranes;mitochondrion","","COA3","ENSG00000183978","Thermogenesis","","Mitochondrial complex IV assembly",611.3,1008.7,534.7,604.4,982.6,283.6,1.1518764032930608,0.2039859234448819,0.7238554325537271,0.14034816186005572,0.8072412811313994,0.09299663702243975,6554]
["Q9Y2R9","28S ribosomal protein S7, mitochondrial [OS=Homo sapiens]",15,3,10,3,242,28.1,9.99,35.8,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPS7","ENSG00000125445","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1272.8,2003.2,1281.8,1572,1982.6,1426.1,0.9150922561085791,-0.12801089715087252,0.6564050423122965,0.18282809148244916,0.7568487859694865,0.12099088137045201,6339]
["Q9Y2S0-1","DNA-directed RNA polymerases I and III subunit RPAC2 [OS=Homo sapiens]",24,3,7,3,133,15.2,5.8,19.33,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","POLR1D","ENSG00000186184; ENSGGOG00000004235; ENSNLEG00000000358; ENSPTRG00000005734","RNA polymerase; Cytosolic DNA-sensing pathway","","Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway",545.6,574.3,485.8,604.5,638.3,889.7,0.7529660023446658,-0.409343368577198,0.13408906591140346,0.872606634586478,0.3713743776985403,0.43018806292255474,2639]
["Q9Y2S7","Polymerase delta-interacting protein 2 [OS=Homo sapiens]",41,12,33,12,368,42,8.63,108.07,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component","nucleic acid binding activity","POLDIP2","ENSG00000004142","","","",3123.6,3228.4,3224.4,3231,2999.9,5148.5,0.8415557938028367,-0.24886917178809445,0.42784980914397225,0.368708657405524,0.5988422548895621,0.22268756300847664,5222]
["Q9Y2T2","ap-3 complex subunit mu-1 [OS=Homo sapiens]",30,8,16,7,418,46.9,6.93,58.53,"transport","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","AP3M1","ENSG00000185009","Lysosome","Association of TriC/CCT with target proteins during biosynthesis","",1488.9,1560.2,1518.6,1369.3,1354.9,1120.2,1.1881437935698682,0.24870944701111433,0.04443987626896729,1.3522271589071275,0.21917075280019022,0.659217400666464,1482]
["Q9Y2U5","Mitogen-activated protein kinase kinase kinase 2 [OS=Homo sapiens]",8,4,5,2,619,69.7,8,15.49,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus","kinase activity;other molecular function","MAP3K2","ENSG00000169967","MAPK signaling pathway; Gap junction; GnRH signaling pathway","","IL-1 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; MAPK cascade; EGF/EGFR signaling pathway; Insulin signaling; Malignant pleural mesothelioma",176,196.7,218.7,230.2,191.5,185.3,0.9742998352553541,-0.03756227302272033,0.7946340471294132,0.09983283096999487,0.8619739166620483,0.06450587573112333,6738]
["Q9Y2U8","inner nuclear membrane protein Man1 [OS=Homo sapiens]",29,20,56,20,911,99.9,7.55,184,"cell organization and biogenesis;other biological processes","other membranes;nucleus","nucleic acid binding activity","LEMD3","ENSG00000174106","","RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOG GTPase cycle; RND2 GTPase cycle; RHOD GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; Initiation of Nuclear Envelope (NE) Reformation; Depolymerisation of the Nuclear Lamina","Envelope proteins and their potential roles in EDMD physiopathology",5088.2,5191.7,5254.4,5421.7,5449.2,6775,0.8803348086524346,-0.18387578145723207,0.19220281971348513,0.71624024529898,0.43831838043240645,0.35821031726984326,3205]
["Q9Y2V2","Calcium-regulated heat-stable protein 1 [OS=Homo sapiens]",29,4,22,4,147,15.9,8.21,91.27,"signal transduction;other biological processes","cytosol;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","CARHSP1","ENSG00000153048","","","",3013.6,3079.1,3099.4,2641.4,2660.6,2835.7,1.129569780159013,0.17577339722923715,6.321391680556768E-3,2.1991872994627095,0.08619972349475638,1.0644941272715067,536]
["Q9Y2V7-1","Conserved oligomeric Golgi complex subunit 6 [OS=Homo sapiens]",7,5,6,5,657,73.2,5.76,14.61,"other metabolic processes;transport","other membranes;ER/Golgi","","COG6","ENSG00000133103","","Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network; COPI-mediated anterograde transport","",327.6,337.4,352.1,313.5,311.1,765.2,0.7318319182616204,-0.4504157558521239,0.45725161314697277,0.3398447536927856,0.619127832621568,0.20821967202931044,5398]
["Q9Y2W1","Thyroid hormone receptor-associated protein 3 [OS=Homo sapiens]",38,42,191,41,955,108.6,10.15,496.99,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","THRAP3","ENSG00000054118","","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","Interactome of polycomb repressive complex 2 (PRC2)",28640.1,26828.5,28013.5,26341.1,28273.6,22863.1,1.0774970378611681,0.10768390321796767,0.2968159643894701,0.5275127440271195,0.5240163970344534,0.2806551232640454,4140]
["Q9Y2W2","WW domain-binding protein 11 [OS=Homo sapiens]",17,12,38,12,641,70,8.38,88.86,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","WBP11","ENSG00000084463","Spliceosome","mRNA Splicing - Major Pathway","",4425.6,4402.6,4394.9,6116.1,6297.7,6088.9,0.7146578607446482,-0.4846753715182361,1.1889661538291534E-5,4.924830508219366,0.010862692022921602,1.9640625333273367,8]
["Q9Y2W6","tudor and KH domain-containing protein [OS=Homo sapiens]",27,12,19,12,561,62,5.02,53.9,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","mitochondrion;other cell component","nucleic acid binding activity","TDRKH","ENSG00000182134","","PIWI-interacting RNA (piRNA) biogenesis","",2081.8,1991.4,2047.3,2171.1,2042.3,2490.2,0.9130168864490722,-0.13128655146752216,0.22535400828372595,0.6471347128979837,0.47154664945483915,0.32647533665165746,3493]
["Q9Y2X0-1","Mediator of RNA polymerase II transcription subunit 16 [OS=Homo sapiens]",7,7,8,7,877,96.7,7.37,15.28,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","MED16","ENSG00000175221","Thyroid hormone signaling pathway","Transcriptional regulation of white adipocyte differentiation; Generic Transcription Pathway; PPARA activates gene expression","",790.2,716.5,750.9,807.2,817.6,1086.3,0.8327247242816567,-0.2640884354886872,0.1823358762564951,0.7391278715134931,0.4256444968248875,0.3709529772464354,3131]
["Q9Y2X3","Nucleolar protein 58 [OS=Homo sapiens]",52,27,199,27,529,59.5,8.92,613.24,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NOP58","ENSG00000055044","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; SUMOylation of RNA binding proteins; rRNA modification in the nucleus and cytosol","",27686.6,27102.1,27676.4,24997,25124,15352.5,1.2595187365880853,0.3328725837487362,0.1555519545756574,0.8081245274283778,0.3953161460338943,0.4030554472552498,2876]
["Q9Y2X7-1","ARF GTPase-activating protein GIT1 [OS=Homo sapiens]",27,17,25,15,761,84.3,6.8,70.26,"developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","GIT1","ENSG00000108262","Endocytosis; Regulation of actin cytoskeleton; Epithelial cell signaling in Helicobacter pylori infection","RHOJ GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOU GTPase cycle; CDC42 GTPase cycle; RHOQ GTPase cycle; RHOV GTPase cycle; Ephrin signaling; Activation of RAC1 downstream of NMDARs","CAMKK2 pathway; Regulation of actin cytoskeleton",2103.6,2086.8,2130.1,2088.4,2070.2,1963.3,1.0324409088681619,0.046059212228307306,0.18174932537593128,0.7405271924967329,0.4250898621352582,0.3715192522928539,3125]
["Q9Y2X9","Zinc finger protein 281 [OS=Homo sapiens]",1,1,2,1,895,96.9,8.48,4.27,"developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF281","ENSG00000162702","","","Mesodermal commitment pathway",69.3,65.1,66.1,95.8,122.9,102.6,0.6240273887332711,-0.6803187441291294,0.008114857005098704,2.0907191286342655,0.09414522198454989,1.0262017162038743,630]
["Q9Y2Y0","ADP-ribosylation factor-like protein 2-binding protein [OS=Homo sapiens]",34,5,13,5,163,18.8,4.35,30.82,"signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","ARL2BP","ENSG00000102931","","Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane","Ciliopathies",1253.2,1246.7,1328.8,1387.7,1358.9,869.9,1.058675515000691,0.08226046975178374,0.6988058802323627,0.1556434492218444,0.788205583120114,0.10336049320846477,6480]
["Q9Y2Y9","Krueppel-like factor 13 [OS=Homo sapiens]",9,2,2,1,288,31.2,9.54,6.01,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KLF13","ENSG00000169926; ENSG00000275746","","","15q13.3 copy number variation syndrome",69.8,77.3,77.3,195,197.1,225.9,0.3631067961165048,-1.461534162182944,2.169444834555325E-4,3.663651388794884,0.019337161336298623,1.7136072792946275,82]
["Q9Y2Z0-1","Protein SGT1 homolog [OS=Homo sapiens]",46,14,43,14,365,41,5.16,124.5,"cell cycle OR cell proliferation;other biological processes","cytosol;nucleus;other cell component","other molecular function","SUGT1","ENSG00000165416; ENSPTRG00000005906","NOD-like receptor signaling pathway","The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection","Nucleotide-binding oligomerization domain (NOD) pathway",5498.5,5693.2,5511.6,5475.8,5403.5,4255.8,1.103613454816949,0.14223495067602457,0.26146926084144095,0.5825793608373764,0.5009380937064462,0.3002159412443026,3815]
["Q9Y2Z2-6","Isoform 7 of Protein MTO1 homolog, mitochondrial [OS=Homo sapiens]",10,6,7,6,732,81.5,8.16,15.6,"","","","MTO1","","","","",238.6,250.6,281.8,304.9,309.6,282.4,0.8596276061991304,-0.2182162804708211,0.05241286460637535,1.2805621034391053,0.23516613100552328,0.6286252258636418,1629]
["Q9Y2Z4","Tyrosine--tRNA ligase, mitochondrial [OS=Homo sapiens]",27,10,15,10,477,53.2,8.98,35.42,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;mitochondrion;nucleus","nucleic acid binding activity;other molecular function","YARS2","ENSG00000139131","Aminoacyl-tRNA biosynthesis","Mitochondrial tRNA aminoacylation","Orexin receptor pathway",1332.7,1318.3,1390.1,1303.9,1286.9,1083,1.0999782241820457,0.13747496359035727,0.1746481572896069,0.7578359922374843,0.41620586293763834,0.38069180633599686,3067]
["Q9Y2Z9-1","Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial [OS=Homo sapiens]",6,3,4,3,468,50.8,7.3,4.76,"other metabolic processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","COQ6","ENSG00000119723","Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways; Biosynthesis of cofactors","Ubiquinol biosynthesis","Nephrotic syndrome",379.7,392.3,425.3,336.2,279.4,198.9,1.4699815837937387,0.5557980808195478,0.03871376191446229,1.4121346251338844,0.20459789286536867,0.689098843359222,1383]
["Q9Y303","N-acetylglucosamine-6-phosphate deacetylase [OS=Homo sapiens]",22,7,18,1,409,43.7,6.7,58.49,"other metabolic processes","cytosol","other molecular function","AMDHD2","ENSG00000162066","Amino sugar and nucleotide sugar metabolism; Metabolic pathways","Synthesis of UDP-N-acetyl-glucosamine","",107.4,100.6,94.6,116.2,133.1,132.4,0.792769190463715,-0.335027198998821,0.016561297795986574,1.7809056335202642,0.1336054366345098,0.8741758693131044,906]
["Q9Y303-3","Isoform 3 of N-acetylglucosamine-6-phosphate deacetylase [OS=Homo sapiens]",19,8,18,2,594,63.6,7.53,56.95,"","","","AMDHD2","","","","",1478.5,1462.6,1558.6,1541.1,1527.1,2130.1,0.8656099109324202,-0.20821107727162122,0.3109238837145916,0.5073459162100781,0.5342131325975434,0.2722854398928154,4254]
["Q9Y305-1","Acyl-coenzyme A thioesterase 9, mitochondrial [OS=Homo sapiens]",34,14,39,14,439,49.9,8.6,116.05,"other metabolic processes","mitochondrion","other molecular function","ACOT9","ENSG00000123130","","Mitochondrial Fatty Acid Beta-Oxidation","VEGFA-VEGFR2 signaling pathway",2961.4,2877.9,2908.6,2837.9,2676.8,3382.1,0.9832636453556334,-0.024349792411975886,0.8285755559268538,0.08166788310950036,0.8835802069257914,0.05375402131937553,6854]
["Q9Y312","Protein AAR2 homolog [OS=Homo sapiens]",24,6,14,6,384,43.4,5.96,36.75,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","","AAR2","ENSG00000131043","","","Ciliary landscape",1113.6,1066.8,1114.2,1128.1,1185.6,1205,0.9363117060277943,-0.09493919982409274,0.05549905702583689,1.2557143958314627,0.24260921519248915,0.6150927070504872,1672]
["Q9Y314","nitric oxide synthase-interacting protein [OS=Homo sapiens]",45,8,17,8,301,33.2,8.82,55.24,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","NOSIP","ENSG00000142546","","NOSIP mediated eNOS trafficking","",1212.6,1272.2,1141.4,1297,1334,865.9,1.03697560696617,0.052381957677804784,0.7946554069781456,0.09982115724446256,0.861869174892902,0.06455865173219189,6739]
["Q9Y315","deoxyribose-phosphate aldolase [OS=Homo sapiens]",31,10,21,10,318,35.2,8.94,65.5,"other metabolic processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","DERA","ENSG00000023697","Pentose phosphate pathway; Metabolic pathways","Neutrophil degranulation; Pentose phosphate pathway","",2905.6,2749.2,2876.4,2670.1,2677.3,2588.8,1.074972908948867,0.10430030203091302,0.023666305164215567,1.6258695397915213,0.15869451783968033,0.7994380758481721,1090]
["Q9Y316-1","Protein MEMO1 [OS=Homo sapiens]",39,9,21,9,297,33.7,7.14,62.18,"other biological processes","","other molecular function","LOC111154137; LOC114499315; MEMO1","ENSANAG00000021250; ENSCANG00000020056; ENSCATG00000030724; ENSCCAG00000037443; ENSCHIG00000006439; ENSCJAG00000003208; ENSDLEG00000015222; ENSECAG00000019946; ENSFCAG00000001385; ENSG00000162959; ENSHGLG00000018935; ENSMMUG00000003908; ENSMNEG00000040106; ENSMODG00000047380; ENSPANG00000022798; ENSPCOG00000018130; ENSPCTG00005009736; ENSPTRG00000050445; ENSRFEG00010015180; ENSSSCG00000008515; ENSSSCG00070008027; ENSVURG00010020209; ENSVVUG00000007616","","ERBB2 Regulates Cell Motility; ERBB2 Regulates Cell Motility","",2281.7,2126.4,2195.1,2141.8,2131.2,1889.4,1.0715305725042195,0.09967301302985924,0.19258621499407275,0.7153748021868895,0.43864526188584535,0.3578865573984206,3209]
["Q9Y320","Thioredoxin-related transmembrane protein 2 [OS=Homo sapiens]",40,11,38,11,296,34,8.69,125.59,"developmental processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","TMX2","ENSG00000213593","","","",5194.8,5201.4,5213.2,4534.8,4799.9,4497.3,1.128499132446501,0.17440530943306157,3.418836844726574E-3,2.4661216243059676,0.06440277963429518,1.191095388016202,388]
["Q9Y333","U6 snRNA-associated Sm-like protein LSm2 [OS=Homo sapiens]",75,6,22,6,95,10.8,6.52,72.61,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LSM2","ENSG00000172850; ENSG00000204392; ENSG00000224979; ENSG00000225998; ENSG00000231502; ENSG00000236826","RNA degradation; Spliceosome","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease; mRNA Splicing - Minor Pathway","mRNA processing",2528.8,2960,2420.4,2644.8,2300,1727.3,1.1854138876815397,0.24539086456849357,0.2596762258575753,0.5855678095216179,0.49972973533254816,0.30126480803864375,3798]
["Q9Y365","START domain-containing protein 10 [OS=Homo sapiens]",12,2,4,2,291,33,7.12,6.11,"transport","other membranes;cytosol;cytoskeleton;other cell component","other molecular function","STARD10","ENSG00000214530","","Synthesis of PC","",8.9,13,17.4,17,12,3.9,1.1945288753799392,0.256441728523365,0.6627483762909587,0.17865132759900423,0.7617593776239373,0.11818219069864476,6359]
["Q9Y371","Endophilin-B1 [OS=Homo sapiens]",28,12,35,11,365,40.8,6.04,97.7,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SH3GLB1","ENSG00000097033","Autophagy; Endocytosis","","Nanoparticle triggered autophagic cell death; Senescence and autophagy in cancer",3620.2,3495,3590,3687.5,3427,1953.7,1.1805209413113957,0.23942363382249238,0.3702905404909428,0.4314573823741577,0.5619712542459097,0.2502858987399529,4816]
["Q9Y375","Complex I intermediate-associated protein 30, mitochondrial [OS=Homo sapiens]",36,11,26,11,327,37.7,7.64,91.39,"cell organization and biogenesis;other metabolic processes","other membranes;cytosol;mitochondrion","other molecular function","NDUFAF1","ENSG00000137806","Thermogenesis","Complex I biogenesis","Mitochondrial immune response to SARS-CoV-2",2678.8,2741.2,2768.2,2697.6,2847.7,3446.4,0.910639812271317,-0.13504756095213305,0.30940245206245937,0.5094762487718305,0.5329772618723817,0.27329131865447337,4243]
["Q9Y376","Calcium-binding protein 39 [OS=Homo sapiens]",45,16,38,16,341,39.8,6.89,98.08,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","CAB39","ENSG00000135932","mTOR signaling pathway; AMPK signaling pathway","Neutrophil degranulation; Energy dependent regulation of mTOR by LKB1-AMPK","AMP-activated protein kinase (AMPK) signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias",6272.1,6362.9,6133.4,6320.1,6471.8,6590.3,0.9683317683235134,-0.04642666876129764,0.11741034657968044,0.9302936299668818,0.3491262095813199,0.45701754663334415,2458]
["Q9Y383","Putative RNA-binding protein Luc7-like 2 [OS=Homo sapiens]",40,20,182,14,392,46.5,10.01,519.86,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","LUC7L2","ENSG00000146963","","","",20064,19627.4,19980.1,20480.8,21202.6,18635.2,0.9892719658612767,-0.015560900636005986,0.7948313647938436,0.09972500355501428,0.86193211354276,0.0645269382063612,6740]
["Q9Y385","ubiquitin-conjugating enzyme e2 j1 [OS=Homo sapiens]",33,9,26,9,318,35.2,6.74,93.82,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","UBE2J1","ENSG00000198833","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum; Parkinson disease; Pathways of neurodegeneration","Antigen processing: Ubiquitination & Proteasome degradation","Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway",1619.2,1755.1,1788.7,2608.3,2758.8,3543.6,0.5794157585823785,-0.7873291722405884,0.013251287716784618,1.877741916359628,0.12001692927134916,0.9207574891977256,807]
["Q9Y388","RNA-binding motif protein, X-linked 2 [OS=Homo sapiens]",15,5,9,5,322,37.3,9.83,24.14,"RNA metabolism OR transcription;other metabolic processes","nucleus","","RBMX2","ENSG00000134597","","","",1337.2,1271.1,1341,1429.7,1465.7,1287.6,0.9441310064546977,-0.08294103482456479,0.2566265644136928,0.5906983901233943,0.49634388973264904,0.3042173201564359,3779]
["Q9Y394","Dehydrogenase/reductase SDR family member 7 [OS=Homo sapiens]",40,9,16,9,339,38.3,8.32,51.28,"","","other molecular function","DHRS7","ENSG00000100612","","","",1624.8,1718.8,1714.8,1497.4,1495,1290.3,1.1811240572536017,0.24016050358771637,0.026316128181242994,1.5797780068974796,0.1682804732079659,0.7739662754087884,1143]
["Q9Y399","28S ribosomal protein S2, mitochondrial [OS=Homo sapiens]",12,5,13,5,296,33.2,9.26,31.26,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPS2","ENSG00000122140","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",2072.7,1983.5,2079.3,1887.4,1788.1,1304.1,1.2321270784801992,0.3011510596354781,0.1027585093537895,0.9881822043679259,0.3310101123256269,0.4801587383688889,2269]
["Q9Y3A0-1","Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial [OS=Homo sapiens]",15,4,6,4,265,29.6,9.17,14.49,"other metabolic processes","other membranes;mitochondrion;other cell component","","COQ4","ENSG00000167113","","","",186.5,172.4,166.5,188.1,200.5,285.5,0.7794095831479008,-0.35954642476743187,0.187104106062015,0.7279166816581493,0.4314018647341538,0.36511798199192774,3170]
["Q9Y3A3","MOB-like protein phocein [OS=Homo sapiens]",46,7,22,7,225,26,5.78,49.1,"","other membranes;ER/Golgi;other cell component","other molecular function","MOB4","ENSG00000115540","","","",1006.3,1264.8,988.5,1157.1,1134.6,928.1,1.012361016212187,0.017723858629773676,0.9139006123080972,0.039101031698463753,0.944928501253343,0.024601051475789754,7069]
["Q9Y3A4","Ribosomal RNA-processing protein 7 homolog A [OS=Homo sapiens]",21,5,9,5,280,32.3,9.58,22.92,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","","RRP7A","ENSG00000189306","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",932.5,969.1,790.2,2353.5,2293.2,1679.8,0.42548012329091917,-1.2328363582744175,0.005482022062402478,2.2610592209744897,0.08127403499817384,1.0900481783677467,493]
["Q9Y3A5","Ribosome maturation protein SBDS [OS=Homo sapiens]",54,17,52,17,250,28.7,8.75,132.39,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;translation activity;nucleic acid binding activity","SBDS","ENSG00000126524","Ribosome biogenesis in eukaryotes","","",7182.2,7618.3,6915.9,7376.6,6836.8,6523.9,1.047214439681154,0.06655689536062066,0.36863979252756685,0.43339778701607307,0.562033425862325,0.25023785482973515,4794]
["Q9Y3A6-1","Transmembrane emp24 domain-containing protein 5 [OS=Homo sapiens]",36,7,15,7,229,26,4.84,29.15,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED5","ENSG00000117500","","WNT ligand biogenesis and trafficking","",2133.1,2152.5,2144.5,1839.6,1838.2,1107.8,1.3436350718823136,0.4261413587457233,0.08776685993402385,1.056669439272679,0.30402273898473003,0.5170939326863986,2110]
["Q9Y3B2","Exosome complex component csl4 [OS=Homo sapiens]",28,4,6,4,195,21.4,8.24,17.07,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","EXOSC1","ENSG00000171311","RNA degradation","Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease","",730.7,776.8,707.7,739.7,595.9,337.1,1.3243259400968495,0.4052582386786406,0.2048600589379584,0.6885427066730239,0.45018706277135834,0.3466069896725514,3326]
["Q9Y3B3-1","Transmembrane emp24 domain-containing protein 7 [OS=Homo sapiens]",33,6,21,6,224,25.2,6.89,52.45,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED7","ENSG00000134970; ENSPTRG00000017152","","COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic","Regulation of toll-like receptor signaling pathway",2807.7,2952.5,2802.2,2413.6,1963.2,2249.3,{"$f":"AVERAGE(S7106:U7106)/AVERAGE(V7106:X7106)","v":1.2922231780383633},{"$f":"LOG(Y7106,2)","v":0.3698552573719398},{"$f":"TTEST(V7106:X7106,S7106:U7106,2,2)","v":0.010076211307456812},1.9967027335220564,{"$f":"AA7106*7309/AE7106","v":0.10551150207192239},0.9767001942612445,698]
["Q9Y3B4","Splicing factor 3B subunit 6 [OS=Homo sapiens]",11,1,1,1,125,14.6,9.38,2.98,"RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus","nucleic acid binding activity","SF3B6","ENSG00000115128","Spliceosome","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","",33.3,40.8,47.4,52.7,55.7,129.9,0.5098615190935795,-0.971822637697128,0.2025821169484496,{"$f":"-LOG10(AA7107)","v":0.6933988948760069},0.4474683266171708,{"$f":"-LOG10(AC7107)","v":0.34923770015188704},3309]
["Q9Y3B6","ER membrane protein complex subunit 9 [OS=Homo sapiens]",8,1,3,1,208,23,5.91,12.27,"cell organization and biogenesis","other membranes;ER/Golgi;other cell component","","EMC9","ENSG00000100908; ENSG00000285377","","","",84.9,98.4,98.3,91.2,105.2,167.6,0.7736263736263738,-0.3702911164487611,0.3146423469358683,0.5021828271580109,0.5365657754909616,0.2703770319798478,4286]
["Q9Y3B7-1","39S ribosomal protein L11, mitochondrial [OS=Homo sapiens]",58,12,42,12,192,20.7,9.91,125.25,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL11","ENSG00000174547; ENSPPAG00000028194; ENSPTRG00000003924","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",6184.2,5786.1,5866.5,5465.8,6521.3,4421.4,1.0870463479294268,0.12041345324696294,0.4842156843370324,0.3149611473380986,0.6365346109387355,0.19617797703618312,5560]
["Q9Y3B8-1","Oligoribonuclease, mitochondrial [OS=Homo sapiens]",32,6,20,6,237,26.8,6.87,64.33,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","REXO2","ENSG00000076043; ENSPPAG00000039849; ENSPTRG00000004306","Ribosome biogenesis in eukaryotes","","",1628.2,2172.5,1557.3,2298.5,2291.8,2560.6,0.749276314869457,-0.4164302472596256,0.04887373542081461,1.3109244665652267,0.22796307095771154,0.6421355011498437,1567]
["Q9Y3B9","RRP15-like protein [OS=Homo sapiens]",16,5,12,5,282,31.5,5.52,20.14,"RNA metabolism OR transcription;other metabolic processes","other cell component","","RRP15","ENSG00000067533","","","",1819.8,1891.5,1659.5,2733.3,2804.3,1870,0.7250391489821264,-0.4638691983563378,0.09223013938262901,1.0351271350349895,0.31252206246992836,0.5051193182535616,2157]
["Q9Y3C0","WASH complex subunit 3 [OS=Homo sapiens]",17,2,3,2,194,21.2,4.46,8.94,"cell organization and biogenesis;transport","other cytoplasmic organelle;other cell component","","WASHC3","ENSG00000120860","Endocytosis","","",350.8,380.1,350.9,473,479.8,205,0.9343582656762828,-0.09795225907538074,0.7945383574070044,0.0998851318007274,0.8619980487290776,0.06449371726943273,6737]
["Q9Y3C1","nucleolar protein 16 [OS=Homo sapiens]",14,3,4,3,178,21.2,9.94,6.24,"other biological processes","nucleus;other cell component","","NOP16","ENSG00000048162","","","",402.4,272.6,274.9,533.5,442.7,562.8,0.6172189733593242,-0.6961456837391145,0.02488037256905443,1.604143120626195,0.16427339034075775,0.7844327796209448,1107]
["Q9Y3C4","EKC/KEOPS complex subunit TPRKB [OS=Homo sapiens]",25,3,10,3,175,19.6,6.79,31.28,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","TPRKB","ENSG00000144034","","tRNA modification in the nucleus and cytosol","",1029.6,953.6,1028.7,1014.4,967.4,741.5,1.1059743693313258,0.14531795187727042,0.33533468288139534,0.47452152618634325,0.5475784622833152,0.2615536421586827,4476]
["Q9Y3C6","Peptidyl-prolyl cis-trans isomerase-like 1 [OS=Homo sapiens]",34,5,30,5,166,18.2,7.99,62.77,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","PPIL1","ENSG00000137168","Spliceosome","mRNA Splicing - Major Pathway","",4145.4,4426,4161.7,4385.9,4618.2,5330.9,0.8882525287757237,-0.17095820410091503,0.14814659548359774,0.8293083244719904,0.3860261912262445,0.41338322818019774,2805]
["Q9Y3C8","ubiquitin-fold modifier-conjugating enzyme 1 [OS=Homo sapiens]",38,8,27,8,167,19.4,7.4,79.1,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes","","other molecular function","UFC1","ENSG00000143222","","","",4774.4,5247.6,4509.5,5314.4,5642.1,4971.8,0.9123070258596334,-0.13240866727045317,0.18355385352933332,0.7362364934865662,0.42685177074320624,0.3697229126201732,3143]
["Q9Y3D0","Mitotic spindle-associated MMXD complex subunit MIP18 [OS=Homo sapiens]",13,1,2,1,163,17.7,5.19,7.54,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","","CIAO2B","ENSG00000166595","","Cytosolic iron-sulfur cluster assembly","",47.6,67.1,46.8,66.6,68,98.4,0.6931330472103004,-0.5287957899603553,0.12507381987769575,0.9028335861700989,0.3600490545435519,0.4436383251598481,2539]
["Q9Y3D2","Methionine-R-sulfoxide reductase B2, mitochondrial [OS=Homo sapiens]",16,1,1,1,182,19.5,8.63,5.54,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response","cytosol;mitochondrion;other cell component","cytoskeletal activity;other molecular function","MSRB2","ENSG00000148450","","Protein repair","Sulindac metabolic pathway; Methionine de novo and salvage pathway",65.2,64,82.3,61.5,71.3,129.9,0.8051008755234106,-0.31275853712632,0.4841264358844785,0.3150412019174934,0.6365317718797722,0.1961799140720804,5559]
["Q9Y3D3","28S ribosomal protein S16, mitochondrial [OS=Homo sapiens]",34,4,10,4,137,15.3,9.5,31.7,"protein metabolism;other metabolic processes","other membranes;cytosol;mitochondrion;translational apparatus","other molecular function","MRPS16","ENSG00000182180","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",926.2,1086,939.2,1015.8,1111.7,910.5,0.9714944042132984,-0.0417224089449612,0.7283280607376204,0.1376729573960757,0.8108682095858747,0.09104972593760088,6565]
["Q9Y3D6","mitochondrial fission 1 protein [OS=Homo sapiens]",20,3,14,3,152,16.9,8.79,36.07,"cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","FIS1","ENSG00000214253","Mitophagy","Class I peroxisomal membrane protein import","CAMKK2 pathway",1061.1,1048.5,1039.8,810,942.1,613.5,1.3313324315184307,0.41287085481160934,0.05238423634109368,1.2807993828644932,0.23518205369597894,0.6285958215337027,1628]
["Q9Y3D8","Adenylate kinase isoenzyme 6 [OS=Homo sapiens]",47,5,11,5,172,20,4.58,41.12,"other metabolic processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","AK6","ENSG00000085231; ENSG00000279247","Purine metabolism; Metabolic pathways; Biosynthesis of cofactors; Ribosome biogenesis in eukaryotes","Interconversion of nucleotide di- and triphosphates","",894.7,1111.5,829.7,1085.3,917.8,1281.6,0.8633665174901819,-0.2119549506489477,0.3309304912328013,0.4802632160251563,0.5457515704920002,0.26300500586155673,4432]
["Q9Y3D9","28S ribosomal protein S23, mitochondrial [OS=Homo sapiens]",19,4,5,4,190,21.8,8.9,13.39,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus","other molecular function","MRPS23","ENSG00000181610","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",922.6,1066.7,901.4,989.6,990.3,417.1,1.2059657905715477,0.2701889831312165,0.45238295174896376,0.3444937700172723,0.616418157034522,0.21012457731286072,5364]
["Q9Y3E0","vesicle transport protein GOT1B [OS=Homo sapiens]",25,4,27,4,138,15.4,10.36,67.71,"transport","other membranes;ER/Golgi;other cell component","","GOLT1B","ENSG00000111711","","","",2081,2217.8,2093.1,1868.5,1967.7,2015.4,1.0923337206917765,0.12741368376159706,0.042903583662707294,1.3675064304274733,0.21581713213401765,0.6659140828415219,1453]
["Q9Y3E1","Hepatoma-derived growth factor-related protein 3 [OS=Homo sapiens]",18,3,6,2,203,22.6,7.99,12.72,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;nucleus","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function","HDGFL3","ENSG00000166503","","","",195.7,185.3,218.2,165.9,180.7,340.5,0.8720710231407365,-0.19748245924255384,0.6327811711262907,0.19874645207297728,0.7415420201638703,0.12986423424013593,6237]
["Q9Y3E2","BolA-like protein 1 [OS=Homo sapiens]",9,1,1,1,137,14.3,7.96,2.23,"","mitochondrion","","BOLA1","ENSG00000178096","","","",53.3,45.2,54,39.9,54.3,19,1.3471731448763253,0.4299352845057289,0.2852837518675893,0.5447229625707246,0.5177896554259276,0.28584663029418317,4027]
["Q9Y3E5","Peptidyl-tRNA hydrolase 2, mitochondrial [OS=Homo sapiens]",56,7,11,7,179,19.2,8.73,36.93,"other biological processes","cytosol;mitochondrion","other molecular function","PTRH2","ENSG00000141378","","Ub-specific processing proteases","",1121.8,1170.4,1110.4,1101,1162.5,819.9,1.1035220860089512,0.14211550415919103,0.37650686738164046,0.42422709797921226,0.565417853645451,0.2476304823387457,4867]
["Q9Y3E7","Charged multivesicular body protein 3 [OS=Homo sapiens]",9,2,2,2,222,25.1,5.12,5.28,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","CHMP3","ENSG00000115561","Endocytosis; Necroptosis","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","",84.7,89.3,86.4,73,85.2,107,0.9819004524886878,-0.026351326946952157,0.8810450001151917,0.05500190906512691,0.9232341083644353,0.03468815912678911,6975]
["Q9Y3F4","Serine-threonine kinase receptor-associated protein [OS=Homo sapiens]",63,16,105,16,350,38.4,5.12,381.28,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","STRAP","ENSG00000023734","","Downregulation of TGF-beta receptor signaling","TGF-beta signaling pathway; Epithelial to mesenchymal transition in colorectal cancer",10550.2,10470.7,10781.2,11101.9,10678.4,10899.1,0.973154341878982,-0.03925946089338286,0.12986325201255866,0.8865137258015849,0.36478497654104197,0.4379630561431795,2602]
["Q9Y3I0","tRNA-splicing ligase RtcB homolog [OS=Homo sapiens]",68,26,142,26,505,55.2,7.23,472.97,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","cytoskeletal activity;other molecular function","RTCB","ENSG00000100220","","tRNA processing in the nucleus","Unfolded protein response",16741.9,16336.9,16925.1,17112.9,16675.2,13862.5,1.0493865764544412,0.0695462405417377,0.48996076561542656,0.30983869539786685,0.6408595626133058,0.19323713095603817,5588]
["Q9Y3I1","F-box only protein 7 [OS=Homo sapiens]",5,2,4,2,522,58.5,6.55,8.54,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","FBXO7","ENSG00000100225","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",442.6,440.5,477.9,552.5,524.8,452.7,0.8895424836601308,-0.16886458607601937,0.15436094188197802,0.8114625801077823,0.39379550583433764,0.4047292445272181,2865]
["Q9Y3L3-1","SH3 domain-binding protein 1 [OS=Homo sapiens]",18,12,33,12,701,75.7,6.77,85.44,"cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","SH3BP1","ENSG00000100092","","RAC1 GTPase cycle","",3159.5,3020.6,3284.7,3053.2,3248.6,2645.7,1.0578150321318802,0.08108738212549242,0.42274003389374903,0.37392662211217087,0.5956828432098346,0.22498490822178288,5187]
["Q9Y3L5","ras-related protein Rap-2c [OS=Homo sapiens]",46,8,43,4,183,20.7,4.94,126.77,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","RAP2C","ENSG00000123728","Tight junction","Neutrophil degranulation","",1291.3,1276.5,1365.3,1119.4,1273.1,966,1.1710882834598781,0.2278498386989387,0.10799639752059217,0.9665907312076998,0.3366079613978713,0.4728756163748289,2345]
["Q9Y3M8-4","Isoform 4 of StAR-related lipid transfer protein 13 [OS=Homo sapiens]",1,1,3,1,1078,120.6,6.95,6.05,"","","","STARD13","","","","",439.6,348.2,423.7,369.8,438,248.1,1.1473624396249644,0.19832119541056584,0.45183223961925034,0.34502278406372444,0.6163571928662002,0.21016753145194159,5358]
["Q9Y3P4","rhomboid domain-containing protein 3 [OS=Homo sapiens]",3,1,3,1,386,40.5,6.58,7.94,"protein metabolism;developmental processes;signal transduction;other biological processes","other membranes","other molecular function","RHBDD3","ENSG00000100263","","","",97.7,103,106,97.9,100.5,223.6,0.7267772511848342,-0.4604148323275279,0.40726573672928107,0.390122125576486,0.5852743353822877,0.23264051953220316,5086]
["Q9Y3P9","Rab GTPase-activating protein 1 [OS=Homo sapiens]",31,26,56,23,1069,121.7,5.25,167.69,"cell cycle OR cell proliferation;transport;other biological processes","cytosol;cytoskeleton","enzyme regulator activity;cytoskeletal activity;other molecular function","RABGAP1","ENSG00000011454","","TBC/RABGAPs","",5802.9,5755.9,5711.7,5691.8,6178.7,5403.9,0.9997742323901262,-0.000325750584507543,0.9957169360619795,1.8641059321833204E-3,0.9972177426249669,1.2100030768398401E-3,7298]
["Q9Y3Q3","Transmembrane emp24 domain-containing protein 3 [OS=Homo sapiens]",12,3,7,3,217,24.8,5.6,19.5,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED3","ENSG00000166557","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport","",1029.4,1083.8,1019.2,867.8,797,536,1.4233006179571064,0.5092404083376217,0.03920769031284267,1.4066287408146143,0.2057207526895672,0.6867218953546049,1393]
["Q9Y3Q8","TSC22 domain family protein 4 [OS=Homo sapiens]",32,8,19,6,395,41,7.21,54.61,"stress response;other biological processes","nucleus","","TSC22D4","ENSG00000166925","","","",1668,1707.8,1509.1,1834.1,1933.2,1824.7,0.8735515021459227,-0.19503533198555734,0.028016818631122833,1.5525811813054182,0.17383270575116877,0.759868509872528,1178]
["Q9Y3R5-1","Protein dopey-2 [OS=Homo sapiens]",3,5,5,5,2298,258.1,6.29,14.93,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","","DOP1B","ENSG00000142197","","","",528.7,555.2,554.1,543.6,547.4,430.1,1.076852277956742,0.1068203552894842,0.3791254628198518,0.4212170465131691,0.5670202594127884,0.24640142365736795,4887]
["Q9Y3S2","zinc finger protein 330 [OS=Homo sapiens]",27,8,24,8,320,36.2,6.16,60.9,"","nucleus;other cell component","other molecular function","ZNF330","ENSG00000109445","","","",2058,2091.5,2265.6,2946.2,2560.4,4084.6,0.6688526983067812,-0.5802395743365317,0.0837275756650162,1.0771314836220973,0.2964945981277148,0.5279832146932982,2064]
["Q9Y3T6","R3H and coiled-coil domain-containing protein 1 [OS=Homo sapiens]",21,7,9,7,440,49.1,5.63,30.34,"","","nucleic acid binding activity","R3HCC1","ENSG00000104679","","","",1195.5,1260,1183,1403.8,1450.8,1583.1,0.8199067084300425,-0.28646833020804874,0.01053500387112926,1.9773653004726093,0.10724281795833393,0.9696317828309367,718]
["Q9Y3T9","Nucleolar complex protein 2 homolog [OS=Homo sapiens]",24,16,48,16,749,84.9,5.62,133.65,"cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","other molecular function","NOC2L","ENSG00000188976","","Regulation of TP53 Activity through Phosphorylation","",5156.2,5245.9,5276.7,5637.9,5219.9,4016.2,1.054107839182466,0.07602246763482949,0.6113740510475354,0.21369299826616533,0.7261184496435548,0.138992528293632,6154]
["Q9Y3U8","60S ribosomal protein L36 [OS=Homo sapiens]",21,2,5,2,105,12.2,11.59,14.47,"protein metabolism;other metabolic processes","cytosol;translational apparatus;nucleus","other molecular function","RPL36","ENSG00000130255","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",401.2,458.1,391.1,417.6,415.4,464.6,0.9636251541307029,-0.053456041217608455,0.5820989727403132,0.2350031671360215,0.7075605175052302,0.1502364090975477,6013]
["Q9Y3X0","coiled-coil domain-containing protein 9 [OS=Homo sapiens]",17,9,13,9,531,59.7,5.4,33.02,"","","","CCDC9","ENSG00000105321","","","IL-18 signaling pathway",2808.8,2282.4,2042.6,3671.6,3065.9,1727.5,0.8427406969875962,-0.24683929849684974,0.5120082541295362,0.2907230376686702,0.6574610557682327,0.1821299671969439,5692]
["Q9Y3Z3","deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [OS=Homo sapiens]",60,33,158,33,626,72.2,7.14,474.84,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","plasma membrane;other membranes;nucleus;other cell component","nucleic acid binding activity;other molecular function","SAMHD1","ENSG00000101347","Human immunodeficiency virus 1 infection","Interferon alpha/beta signaling; Nucleotide catabolism","",20694.5,20409,20951,18719.7,18668.2,15829.7,1.1660522082919935,0.2216323845570552,0.03824346954741944,1.4174427142791426,0.20373288551172644,0.6909388637659024,1372]
["Q9Y448","Small kinetochore-associated protein [OS=Homo sapiens]",3,1,1,1,316,35.4,6.3,0,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KNSTRN","ENSG00000128944","","","Overview of leukocyte-intrinsic Hippo pathway functions",154.1,167.4,129.7,182.9,219.5,132.7,0.8432068772192115,-0.24604146120256865,0.36628072374566173,0.43618593634821057,0.56101127616451,0.25102840946254185,4772]
["Q9Y450-1","HBS1-like protein [OS=Homo sapiens]",41,23,81,23,684,75.4,6.61,246.97,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol","nucleic acid binding activity;other molecular function","HBS1L","ENSG00000112339","mRNA surveillance pathway; Legionellosis","mRNA decay by 3' to 5' exoribonuclease","",7820.9,7845.6,7993,8128.4,7925.3,7937.2,0.9861864290210037,-0.02006769493700387,0.2633464674754818,0.5794725028853687,0.5012498257235147,0.2999457653689264,3840]
["Q9Y478","5'-AMP-activated protein kinase subunit beta-1 [OS=Homo sapiens]",24,4,7,4,270,30.4,6.4,23.12,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","PRKAB1","ENSG00000111725","FoxO signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Apelin signaling pathway; Tight junction; Circadian rhythm; Thermogenesis; Insulin signaling pathway; Adipocytokine signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Insulin resistance; Non-alcoholic fatty liver disease; Alcoholic liver disease; Hypertrophic cardiomyopathy","Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Lipophagy","AMP-activated protein kinase (AMPK) signaling; Target of rapamycin (TOR) signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Angiopoietin-like protein 8 regulatory pathway; Leptin and adiponectin; Lipid metabolism pathway; Genotoxicity pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; Malignant pleural mesothelioma",271.5,285.7,289.5,284,271.2,528.7,0.7811606236737707,-0.3563088664285688,0.3996592422564043,0.39831013936983184,0.5794702244895972,0.23696887492400942,5041]
["Q9Y483","Metal-response element-binding transcription factor 2 [OS=Homo sapiens]",8,3,3,3,593,67.1,8.72,9.82,"","","","","","","","",237.6,224.6,260.9,283,283.3,305.6,0.8293382268608784,-0.2699675025752774,0.018809376089994275,1.7256256098279594,0.14335529701957056,0.8435862551146501,959]
["Q9Y484-1","WD repeat domain phosphoinositide-interacting protein 4 [OS=Homo sapiens]",3,1,3,1,360,39.8,7.14,9.19,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response","other membranes;cytosol;other cell component","other molecular function","WDR45","ENSCANG00000035794; ENSCSAG00000012964; ENSG00000196998; ENSGGOG00000000589; ENSMFAG00000032970; ENSMLEG00000042347; ENSMMUG00000010620","","Macroautophagy","Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway",372.6,352.9,365.5,393.7,394.5,803.6,0.6853876115089835,-0.5450079797388825,0.2888397656350365,0.5393430160643127,0.519215407532337,0.28465242848235944,4066]
["Q9Y485","DmX-like protein 1 [OS=Homo sapiens]",10,21,31,21,3027,337.6,6.34,93.99,"other biological processes","other cell component","","DMXL1","ENSG00000172869","","","",1844.3,1856.5,1924.7,2034.3,1931.5,1955.9,0.9499805799010418,-0.07403007361938954,0.0683520004391713,1.1652487705331716,0.2671576316630498,0.5732324151856975,1870]
["Q9Y487","V-type proton ATPase 116 kDa subunit a isoform 2 [OS=Homo sapiens]",11,8,18,7,856,98,6.61,37.74,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ATP6V0A2","ENSG00000185344","Oxidative phosphorylation; Metabolic pathways; Lysosome; Phagosome; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Tuberculosis; Human papillomavirus infection; Rheumatoid arthritis","ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","",778.1,771.7,811.3,784.2,770.8,1132,0.878712318570897,-0.18653717582479756,0.4124644834855252,0.3846134417572708,0.5884643587342775,0.23027983574963895,5123]
["Q9Y490","Talin-1 [OS=Homo sapiens]",70,136,676,115,2541,269.6,6.07,2295.38,"cell adhesion;cell organization and biogenesis;signal transduction","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","TLN1","ENSG00000137076","Rap1 signaling pathway; Focal adhesion; Platelet activation; Shigellosis; Human T-cell leukemia virus 1 infection","Platelet degranulation ; p130Cas linkage to MAPK signaling for integrins; Signaling by BRAF and RAF1 fusions; XBP1(S) activates chaperone genes; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Smooth Muscle Contraction; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins","Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion",74652.6,73468.2,74051.2,73253.2,73499.4,77350.4,0.9913834263709099,-0.0124849543889495,0.6629369570173904,0.17852776951568347,0.761856323716998,0.11812692328012435,6360]
["Q9Y496","kinesin-like protein KIF3A [OS=Homo sapiens]",11,7,14,7,699,80,6.54,27.19,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF3A","ENSG00000131437","Hedgehog signaling pathway","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Hedgehog 'off' state; Activation of SMO","Hedgehog signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Insulin signaling",980.4,902.5,982,878.7,984.9,1451.3,0.8642492986213763,-0.21048056721354177,0.44637989170137754,0.3502953775109513,0.612348090924431,0.213001631789223,5328]
["Q9Y4A5","Transformation/transcription domain-associated protein [OS=Homo sapiens]",9,29,55,29,3859,437.3,8.19,157.22,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","ER/Golgi;nucleus","other molecular function","TRRAP","ENSG00000196367","Human T-cell leukemia virus 1 infection","Ub-specific processing proteases; HATs acetylate histones; Formation of the beta-catenin:TCF transactivating complex","Rett syndrome causing genes",3214.9,3327.3,3441.5,4027.6,3916.3,5737.7,0.7297172845281255,-0.4545904681691291,0.10621920218104056,0.9737969649171913,0.33608491287498937,0.4735509829253626,2310]
["Q9Y4B4","Helicase ARIP4 [OS=Homo sapiens]",5,5,5,5,1467,162.7,6.09,13.39,"cell organization and biogenesis","nucleus","nucleic acid binding activity;other molecular function","RAD54L2","ENSG00000164080","","","",167.5,164.2,167.6,213.9,197.5,1260.7,0.2986065426708928,-1.743682318646515,0.3286359016893697,0.4832849939932039,0.5439311153640406,0.26445609683037336,4416]
["Q9Y4B5","Microtubule cross-linking factor 1 [OS=Homo sapiens]",11,17,21,15,1905,209.4,6.43,59.89,"cell organization and biogenesis;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MTCL1","ENSG00000168502","","","",1610.4,1553.3,1572,1862.9,1685.3,2081,0.8412740709159383,-0.24935221552787046,0.06164097489845409,1.210130501204902,0.25339363640764956,0.596204295955124,1778]
["Q9Y4B6","DDB1- and CUL4-associated factor 1 [OS=Homo sapiens]",14,17,24,17,1507,168.9,5.06,59.02,"protein metabolism;DNA metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","kinase activity;other molecular function","DCAF1","ENSG00000145041","Human immunodeficiency virus 1 infection","Antigen processing: Ubiquitination & Proteasome degradation","Hippo-Merlin signaling dysregulation",1781.5,1779.2,1873.1,2579.6,2545.3,2725.4,0.6921773690177445,-0.530786322034117,2.1945741806770916E-4,3.6586497346120206,0.019095407960201028,1.7190710587899292,84]
["Q9Y4C1","Lysine-specific demethylase 3A [OS=Homo sapiens]",4,4,5,4,1321,147.2,8.07,17.37,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KDM3A","ENSG00000115548","Thermogenesis","NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; HDMs demethylate histones","Thermogenesis; Male infertility; Vitamin D-sensitive calcium signaling in depression",270.3,262.3,282.2,360.8,345.1,322.8,0.7920676582093903,-0.336304424690903,0.0046003543179572,2.3372087177950203,0.0745543009089782,1.1275272977890078,451]
["Q9Y4C2-1","TRPM8 channel-associated factor 1 [OS=Homo sapiens]",12,8,10,8,921,102.1,6.54,20.97,"other biological processes","plasma membrane;other membranes","other molecular function","TCAF1","ENSG00000198420","","","",669.3,650.9,633,703.6,754.2,665.7,0.9198022133270543,-0.12060442559730089,0.1097215293712159,0.9597081475417079,0.3385203284821515,0.4704152463805,2369]
["Q9Y4C8","Probable RNA-binding protein 19 [OS=Homo sapiens]",6,5,6,5,960,107.3,6.54,18.91,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","RBM19","ENSG00000122965","","","",274.3,275.6,264.9,429.6,476.6,568.1,0.5526690632842705,-0.8555122377098661,0.005739193780544064,2.2411491113045834,0.08290072597232523,1.0814416662604096,506]
["Q9Y4D1","Disheveled-associated activator of morphogenesis 1 [OS=Homo sapiens]",8,9,12,9,1078,123.4,7.23,24.91,"cell-cell signaling;cell organization and biogenesis;signal transduction","plasma membrane;other membranes;cytosol;cytoskeleton","cytoskeletal activity;other molecular function","DAAM1","ENSG00000100592","Wnt signaling pathway","RHO GTPases Activate Formins; RHOA GTPase cycle; PCP/CE pathway; RHOC GTPase cycle; CDC42 GTPase cycle; RHOB GTPase cycle","Physico-chemical features and toxicity-associated pathways; Wnt signaling; Genotoxicity pathway",1294.8,1458,1490.1,1127.9,1187.2,1162.8,1.2199603208832914,0.2868342250046905,0.015395580408197905,1.812603933696405,0.1293405714982971,0.8882652244310505,870]
["Q9Y4D8-1","Probable E3 ubiquitin-protein ligase HECTD4 [OS=Homo sapiens]",1,2,2,1,3996,439.1,6.19,7.94,"protein metabolism;other metabolic processes;other biological processes","other membranes","other molecular function","HECTD4","","","","",16.7,19.8,16,18.2,16.3,26.2,0.8649093904448105,-0.20937909370219715,0.44771023873240384,0.34900297357693216,0.6130225056004384,0.212523581144448,5338]
["Q9Y4D8-5","Isoform 5 of Probable E3 ubiquitin-protein ligase HECTD4 [OS=Homo sapiens]",3,3,3,2,1321,145,5.78,9.3,"","","","HECTD4","","","","",95,84.3,102,111.9,93.2,410,0.4573240123557145,-1.1287114232889106,0.33979073648077424,0.4687884652260136,0.5489678366352739,0.26045309959545826,4524]
["Q9Y4E1","WASH complex subunit 2C [OS=Homo sapiens]",31,32,65,7,1318,144.6,4.79,199.88,"","","","","","","","",324.1,376.3,327.2,451,478.4,851.4,0.5770440251572327,-0.7932467024411425,0.1261549222031662,0.8990957998909951,0.3610283188656781,0.4424587309344185,2554]
["Q9Y4E5","E3 SUMO-protein ligase ZNF451 [OS=Homo sapiens]",13,11,16,11,1061,121.4,6.77,39.08,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","ZNF451","ENSG00000112200","","","",915.9,884.5,928.5,1007.2,845,1862.8,0.7345625841184388,-0.445042682457212,0.356985248274935,0.4473497298966653,0.5584771360534032,0.25299460211703545,4672]
["Q9Y4E6-1","WD repeat-containing protein 7 [OS=Homo sapiens]",5,5,8,5,1490,163.7,6.92,26.64,"","ER/Golgi","","WDR7","ENSG00000091157","","","",498.4,541.2,542.8,513.2,514.9,772.1,0.8790134429507832,-0.186042865889411,0.4520935821723868,0.34477165807718896,0.6164835806152938,0.21007848588598607,5360]
["Q9Y4E8-3","Isoform 3 of Ubiquitin carboxyl-terminal hydrolase 15 [OS=Homo sapiens]",36,27,68,26,956,109.7,5.16,185.84,"","","","USP15","","","","",6618.3,6748.8,6462.4,6525.1,6498.2,6906.4,0.994972327731978,-0.007271693049172976,0.840590300077404,0.07541562580710312,0.8926157930067915,0.049335433476863436,6883]
["Q9Y4F1","FERM, RhoGEF and pleckstrin domain-containing protein 1 [OS=Homo sapiens]",6,5,7,5,1045,118.6,8.15,21.83,"cell-cell signaling;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","FARP1","ENSG00000152767","","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOF GTPase cycle","",339.7,326.3,311.2,281.2,288.3,566.1,0.8605142655864743,-0.21672898545713504,0.6049150860768178,0.21830558441608017,0.7217310421376855,0.14162461500266108,6126]
["Q9Y4F3-1","Meiosis regulator and mRNA stability factor 1 [OS=Homo sapiens]",1,2,2,2,1742,192.7,7.87,4.99,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","ER/Golgi;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","MARF1","ENSG00000166783; ENSG00000277140","","","",179,181.1,180.5,240,228.1,183,0.8302872062663186,-0.26831762664060166,0.10129977483968117,0.9943915199506049,0.32833705290608856,0.4836801042806113,2255]
["Q9Y4G6","Talin-2 [OS=Homo sapiens]",8,22,62,2,2542,271.4,5.57,173.61,"cell adhesion;cell organization and biogenesis","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","TLN2","ENSG00000171914","Rap1 signaling pathway; Focal adhesion; Platelet activation; Shigellosis; Human T-cell leukemia virus 1 infection","","Focal adhesion",489.7,548.7,417.9,480.9,430.4,362.1,{"$f":"AVERAGE(S7170:U7170)/AVERAGE(V7170:X7170)","v":1.143631223496152},{"$f":"LOG(Y7170,2)","v":0.19362191417584948},{"$f":"TTEST(V7170:X7170,S7170:U7170,2,2)","v":0.29908335798177266},0.5242077519227525,{"$f":"AA7170*7309/AE7170","v":0.5259865889049029},0.27902532892391935,4156]
["Q9Y4G8","rap guanine nucleotide exchange factor 2 [OS=Homo sapiens]",6,7,11,5,1499,167.3,6.67,18.79,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","RAPGEF2","ENSG00000109756","MAPK signaling pathway; Rap1 signaling pathway; Tight junction","RAF/MAP kinase cascade","MAPK signaling pathway; Genotoxicity pathway",578.2,484,505.8,543.4,520.3,641.7,0.9194323912278645,-0.12118460227990722,0.38372068469542014,{"$f":"-LOG10(AA7171)","v":0.4159847892641472},0.5700435943981353,{"$f":"-LOG10(AC7171)","v":0.24409193014753455},4920]
["Q9Y4H2","Insulin receptor substrate 2 [OS=Homo sapiens]",1,2,3,2,1338,137.2,8.65,4.13,"other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;other molecular function","IRS2","ENSG00000185950","cGMP-PKG signaling pathway; FoxO signaling pathway; Autophagy; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Regulation of lipolysis in adipocytes; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; Growth hormone synthesis, secretion and action; Alzheimer disease; MicroRNAs in cancer","Growth hormone receptor signaling; Interleukin-7 signaling; Signaling by Leptin; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); RAF/MAP kinase cascade; PI3K Cascade; PI3K/AKT activation; Erythropoietin activates Phospholipase C gamma (PLCG); Erythropoietin activates STAT5; Erythropoietin activates RAS; SOS-mediated signalling; IRS activation; Signal attenuation","Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Farnesoid X receptor pathway; Nuclear receptors meta-pathway; Transcription factor regulation in adipogenesis; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; Nonalcoholic fatty liver disease; Insulin signaling; FOXA2 pathway; Alzheimer's disease; EPO receptor signaling; Interferon type I signaling pathways",220,226.1,236.7,347.4,334,420.8,0.6194882961350027,-0.6908510688047678,0.006986760733669583,2.155724129198248,0.08927663322096327,1.0492621961072992,572]
["Q9Y4I1-1","Unconventional myosin-Va [OS=Homo sapiens]",33,53,123,1,1855,215.3,8.48,353.17,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYO5A","ENSG00000197535","Pathogenic Escherichia coli infection","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Insulin processing; Translocation of SLC2A4 (GLUT4) to the plasma membrane","Joubert syndrome",110,99.2,123.5,118.4,109.5,173.9,0.8280238924838227,-0.27225569785042597,0.3411461184389916,0.46705956575918056,0.5496995105093893,0.25987464976005775,4536]
["Q9Y4I1-3","Isoform 3 of Unconventional myosin-Va [OS=Homo sapiens]",32,53,122,1,1880,218.5,8.51,350.7,"","","","MYO5A","","","","",11471.6,11232,11353.2,11176,11246,10427.1,1.0367650864102824,0.05208904066653372,0.2116721900974579,0.6743361966833585,0.45691436427121085,0.34016518857230205,3386]
["Q9Y4J8-1","Dystrobrevin alpha [OS=Homo sapiens]",11,7,7,7,743,83.8,6.89,19.38,"cell-cell signaling;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","other molecular function","DTNA","ENSG00000134769","","","",553.2,540.4,537.2,578,597.4,532.9,0.9546332611368026,-0.06698149153605114,0.26038513155272586,0.5843838183717537,0.5006984810625817,0.3004237260908845,3801]
["Q9Y4K3","TNF receptor-associated factor 6 [OS=Homo sapiens]",20,7,9,7,522,59.5,6.44,27.18,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","TRAF6","ENSG00000175104","MAPK signaling pathway; NF-kappa B signaling pathway; Ubiquitin mediated proteolysis; Autophagy; Endocytosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; IL-17 signaling pathway; Neurotrophin signaling pathway; Alcoholic liver disease; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Yersinia infection; Leishmaniasis; Chagas disease; Toxoplasmosis; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis","Ub-specific processing proteases; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; TRAF6 mediated NF-kB activation; activated TAK1 mediates p38 MAPK activation; Ovarian tumor domain proteases; NRIF signals cell death from the nucleus; Regulated proteolysis of p75NTR; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; PIP3 activates AKT signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; TICAM1,TRAF6-dependent induction of TAK1 complex; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway; TRAF6 mediated IRF7 activation; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling","Regulation of toll-like receptor signaling pathway; IL-1 signaling pathway; RANKL/RANK signaling pathway; IL-17 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Melatonin metabolism and effects; Photodynamic therapy-induced NF-kB survival signaling; Interleukin-1 induced activation of NF-kB; TGF-beta signaling pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor (RLR) pathway; MYD88 distinct input-output pathway; ApoE and miR-146 in inflammation and atherosclerosis; Oxidative damage response; Fibrin complement receptor 3 signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; miRNAs involvement in the immune response in sepsis; Signal transduction through IL1R; Interactions between immune cells and microRNAs in tumor microenvironment; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; 16p11.2 proximal deletion syndrome; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Modulators of TCR signaling and T cell activation; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; T-cell receptor (TCR) signaling pathway; Toll-like receptor signaling pathway",933,928,912.2,910.3,853.5,560.1,1.1933387839407892,0.25500367633238774,0.24030246620866255,0.6192417720370602,0.48318314319645517,0.3158882253481439,3635]
["Q9Y4K4","mitogen-activated protein kinase kinase kinase kinase 5 [OS=Homo sapiens]",2,1,1,1,846,95,7.64,3.44,"","","","","","","","",84.7,73.6,80,81.3,95.1,119.7,0.8047956771361028,-0.3133055389872827,0.17443756420914736,0.7583599863067519,0.4161110172338962,0.3807907853833454,3064]
["Q9Y4L1","Hypoxia up-regulated protein 1 [OS=Homo sapiens]",63,51,778,51,999,111.3,5.22,2458.55,"stress response;transport;other biological processes","non-structural extracellular;ER/Golgi;other cell component","other molecular function","HYOU1","ENSG00000149428; ENSG00000280682","Protein processing in endoplasmic reticulum","XBP1(S) activates chaperone genes; Scavenging by Class F Receptors","VEGFA-VEGFR2 signaling pathway",75527.6,73881.8,75114.3,68812.9,71997.1,62815.2,1.1026321889432154,0.140951623493323,0.06361465950048681,1.1964427930535855,0.25505186302197375,0.5933714998245887,1823]
["Q9Y4L5","E3 ubiquitin-protein ligase RNF115 [OS=Homo sapiens]",3,1,1,1,304,33.7,5.69,1.74,"protein metabolism;other metabolic processes;other biological processes","cytosol","other molecular function","RNF115","ENSG00000265491","","Antigen processing: Ubiquitination & Proteasome degradation","",41.2,52.3,51.4,97.7,110.1,177.6,0.3759730150492995,-1.4112989767387916,0.03301259579925079,1.4813203255040466,0.18909801151780878,0.7233130380052172,1276]
["Q9Y4P1-1","Cysteine protease ATG4B [OS=Homo sapiens]",23,6,17,6,393,44.3,5.07,57.73,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol","other molecular function","ATG4B","ENSG00000168397","Autophagy; Autophagy","Macroautophagy","",1315.3,1308,1322.3,1364.8,1383.3,1917.9,0.8456065152164596,-0.2419416024687224,0.25618171638641635,0.5914518689544725,0.49600852054789857,0.3045108630357066,3775]
["Q9Y4P3","Transducin beta-like protein 2 [OS=Homo sapiens]",37,17,53,17,447,49.8,9.44,156.95,"stress response;signal transduction","other membranes;ER/Golgi","other molecular function","TBL2","ENSG00000106638","","","7q11.23 copy number variation syndrome",7646,7697.3,7776.6,6861.3,6903.2,6922.4,1.117610661819799,0.16041768899636027,4.2614744136109518E-5,4.370440114768241,0.010740384996235327,1.9689801507832239,29]
["Q9Y4P8-1","WD repeat domain phosphoinositide-interacting protein 2 [OS=Homo sapiens]",28,8,18,1,454,49.4,6.46,61,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","WIPI2","ENSG00000157954","Autophagy; Autophagy; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis","Macroautophagy","Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Alzheimer's disease",931.6,976.2,951.1,982.1,906.8,1595.2,0.8205562412100685,-0.2853258749397805,0.3939818043970793,0.4045238351094989,0.5758074401796146,0.23972272777319373,5001]
["Q9Y4P8-6","Isoform 6 of WD repeat domain phosphoinositide-interacting protein 2 [OS=Homo sapiens]",28,8,16,1,443,48.2,6.3,47.61,"","","","WIPI2","","","","",29.8,42.4,30.5,34.5,40.8,48.8,0.8275584206285254,-0.2730669338121616,0.28732977634034407,0.5416193652011765,0.5185415642645863,0.28521642653187207,4050]
["Q9Y4R8","telomere length regulation protein TEL2 homolog [OS=Homo sapiens]",16,9,19,9,837,91.7,5.76,60.21,"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TELO2","ENSG00000100726","Fanconi anemia pathway; mTOR signaling pathway","","Fragile X syndrome; Malignant pleural mesothelioma",864.2,842.7,883.7,872.8,862.6,1042.5,0.9325749667014652,-0.10070839124469917,0.35347239862789803,0.45164449301729415,0.5566752341243927,0.2543980995523512,4641]
["Q9Y4W2","Ribosomal biogenesis protein LAS1L [OS=Homo sapiens]",42,26,58,26,734,83,4.73,167.39,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","LAS1L","ENSG00000001497","","Major pathway of rRNA processing in the nucleolus and cytosol","",5813.1,5534.6,6211.6,5615.1,6194.5,5392.5,1.0207649066102398,0.029650635930088848,0.7199520257764084,0.1426964419503084,0.803992262245954,0.09474813095311004,6545]
["Q9Y4W6","AFG3-like protein 2 [OS=Homo sapiens]",41,33,106,33,797,88.5,8.66,305.32,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;mitochondrion","other molecular function","AFG3L2","ENSG00000141385","Spinocerebellar ataxia","Processing of SMDT1","Ciliary landscape",13091.9,13047.3,14274.9,11146.1,11958.6,9982.4,1.2214458202743668,0.28858987133743097,0.02518157341952907,1.5989171373707065,0.16462622551282466,0.783500979037138,1118]
["Q9Y4X4-1","Krueppel-like factor 12 [OS=Homo sapiens]",4,2,2,1,402,44.2,9.7,3.52,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","KLF12","ENSCANG00000041690; ENSG00000118922; ENSGGOG00000004142; ENSMFAG00000002684; ENSMLEG00000030485; ENSMMUG00000019097; ENSMNEG00000039444; ENSNLEG00000016131; ENSPANG00000007736; ENSPPAG00000031325; ENSRBIG00000037086; ENSRROG00000027231","","","",40.9,26.5,31,44.3,53.6,6.6,0.9416267942583733,-0.08677272162900515,0.8986262283768682,0.046420909721283835,0.9360209638316274,0.028714424366126406,7017]
["Q9Y4X5","E3 ubiquitin-protein ligase ARIH1 [OS=Homo sapiens]",38,15,49,15,557,64.1,5.08,160.36,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","ARIH1","ENSG00000166233","","ISG15 antiviral mechanism","",5217.7,4997.8,5031.4,5067.9,5179.7,4156.1,1.0585405138957353,0.08207648718010487,0.44403114726223125,0.35258656454830123,0.6123440859131412,0.21300447226511732,5300]
["Q9Y4Y9","U6 snRNA-associated Sm-like protein LSm5 [OS=Homo sapiens]",25,1,2,1,91,9.9,4.54,4.63,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LSM5","ENSG00000106355","RNA degradation; Spliceosome","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease","",14.9,20.1,14,19,16.5,4.1,1.2373737373737372,0.3072813189229608,0.563654708697914,0.24898686060790212,0.6947305676008522,0.15818359208819177,5930]
["Q9Y4Z0","U6 snRNA-associated Sm-like protein LSm4 [OS=Homo sapiens]",12,2,4,2,139,15.3,9.99,6.58,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LSM4","ENSG00000130520","RNA degradation; Spliceosome","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease","Ciliary landscape",448.5,516.2,438.8,525.8,525.5,843.3,0.740789612583131,-0.43286422574368205,0.20635325820182088,0.6853886694669602,0.4519736182790257,0.34488691423778,3337]
["Q9Y508-1","E3 ubiquitin-protein ligase RNF114 [OS=Homo sapiens]",18,4,6,4,228,25.7,7.25,19.78,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus","other molecular function","RNF114","ENSG00000124226; ENSPPAG00000043607; ENSPTRG00000013613","","Antigen processing: Ubiquitination & Proteasome degradation","",956,962.9,912.1,879,1014.2,967.6,0.9895833333333333,-0.015106892390208447,0.827560973286957,0.08219999829359602,0.8828847108092788,0.05409600392900642,6851]
["Q9Y512","sorting and assembly machinery component 50 homolog [OS=Homo sapiens]",42,16,73,16,469,51.9,6.9,220.8,"cell organization and biogenesis;transport","other membranes;mitochondrion","","SAMM50","ENSG00000100347","","RAC2 GTPase cycle; Mitochondrial protein import; Cristae formation","",7622.9,7737.4,7597.7,6283.9,6496.4,4590.5,1.3216432173532595,0.4023327683544179,0.03690717904500538,1.4328891483022335,0.1998182012147736,0.6993649549132664,1350]
["Q9Y519","Transmembrane protein 184B [OS=Homo sapiens]",2,1,1,1,407,45.5,6.89,2.07,"","other membranes","","TMEM184B","ENSG00000198792","","","",55,55.3,53.8,46.4,60.4,34.5,1.1613588110403397,0.21581377317977335,0.3681511216585516,0.43397387200548554,0.5618744097311242,0.2503607471641202,4789]
["Q9Y520-7","Isoform 7 of Protein PRRC2C [OS=Homo sapiens]",23,56,122,54,2898,316.9,9.13,331.37,"","","","PRRC2C","","","","",13673.2,13434.1,12435.8,20416.6,21211.3,19705.6,0.6447227045578682,-0.6332493045503905,2.2893676932798582E-4,3.6402844500785445,0.019014759625207368,1.72090916034474,88]
["Q9Y535","DNA-directed RNA polymerase III subunit RPC8 [OS=Homo sapiens]",27,3,6,3,204,22.9,4.58,24.95,"RNA metabolism OR transcription;other metabolic processes;stress response","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","POLR3H","ENSG00000100413","RNA polymerase; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway",400.9,407.6,442,428.3,476.3,650.8,0.8039732544683039,-0.31478058637836387,0.21362086671337804,0.6703563272246906,0.45935713880790824,0.3378495299237774,3399]
["Q9Y547","Intraflagellar transport protein 25 homolog [OS=Homo sapiens]",42,4,11,4,144,16.3,5.03,43.54,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","other molecular function","HSPB11","ENSG00000081870","","Intraflagellar transport","Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); GDNF/RET signaling axis",672.3,702,683,737.8,630.3,562.4,1.065682465682466,0.09177763187971667,0.46028669534951683,0.3369715782665659,0.6204786898394723,0.2072731296270596,5422]
["Q9Y548","Protein YIPF1 [OS=Homo sapiens]",8,3,3,3,306,34.3,5.31,9.76,"transport","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle","other molecular function","YIPF1","ENSG00000058799","","","",379.5,401.6,399.4,407.1,437.9,248.1,1.0799560881895527,0.11097265253771825,0.6485723853904927,0.18804154645527354,0.7517309807832399,0.12393755098318646,6306]
["Q9Y570","Protein phosphatase methylesterase 1 [OS=Homo sapiens]",38,11,21,11,386,42.3,5.97,56.27,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","nucleus","enzyme regulator activity;other molecular function","PPME1","ENSG00000214517","","Cyclin A/B1/B2 associated events during G2/M transition","",2357.8,2401.9,2476.5,2407.3,2241.3,2353.2,1.0334771058870578,0.04750642979960168,0.2621509679581441,0.5814485343717548,0.5011931532320364,0.29999487050680995,3823]
["Q9Y572-1","Receptor-interacting serine/threonine-protein kinase 3 [OS=Homo sapiens]",7,3,3,3,518,56.9,6.47,9.74,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","RIPK3","ENSG00000129465; ENSG00000285379","Necroptosis; NOD-like receptor signaling pathway; Cytosolic DNA-sensing pathway; TNF signaling pathway; Salmonella infection","Regulation of necroptotic cell death; IKK complex recruitment mediated by RIP1; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; TRIF-mediated programmed cell death; TLR3-mediated TICAM1-dependent programmed cell death; TRP channels; Microbial modulation of RIPK1-mediated regulated necrosis","TNF-alpha signaling pathway; Nanoparticle triggered regulated necrosis; Cytosolic DNA-sensing pathway",162.9,157.8,147.3,165.4,163.6,189.6,0.902429618202854,-0.1481136763825276,0.1523948909475805,0.8170295925139145,0.39110051191568324,0.4077116155947603,2848]
["Q9Y575","Ankyrin repeat and SOCS box protein 3 [OS=Homo sapiens]",2,1,1,1,518,57.7,6.27,2.27,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol","","ASB3","ENSG00000115239","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",68.4,73.2,84.1,155.4,146.1,289.7,0.38176589986468196,-1.3892398509543151,0.05923474052055803,1.2274235096427646,0.24953701352435656,0.6028650268856842,1735]
["Q9Y580","RNA-binding protein 7 [OS=Homo sapiens]",6,2,5,2,266,30.5,9.57,13.63,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","RBM7","ENSG00000076053","","","",434.7,494.9,424.7,584.2,643.4,620,0.7330049794327776,-0.4481050960118028,4.131352715264232E-3,2.3839077254412873,0.07172460094029993,1.1443318593929828,421]
["Q9Y587-1","AP-4 complex subunit sigma-1 [OS=Homo sapiens]",7,1,1,1,144,17,5.19,2.06,"transport;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","AP4S1","ENSCANG00000008358; ENSCATG00000035780; ENSG00000100478; ENSGGOG00000003198; ENSMMUG00000003123; ENSPANG00000017427; ENSPCOG00000016646; ENSPPAG00000041450; ENSPTRG00000006239; ENSRROG00000019504","Lysosome","Lysosome Vesicle Biogenesis","",30.9,34.4,29.9,30.7,30,18.3,1.2050632911392405,0.26910892024347827,0.2724418036136153,0.5647262532725305,0.5081084824220246,0.29404355486666006,3919]
["Q9Y592","Centrosomal protein of 83 kDa [OS=Homo sapiens]",2,2,2,2,693,82,6.28,4.99,"","","","","","","","",54.8,54.1,47.8,76.9,55.6,32.7,0.948547215496368,-0.07620850694686515,0.837583475890212,0.07697189914259431,0.8907169540639545,0.050260281167681324,6873]
["Q9Y597","BTB/POZ domain-containing protein KCTD3 [OS=Homo sapiens]",1,1,1,1,815,88.9,7.03,3.19,"cell organization and biogenesis","plasma membrane;other membranes","","KCTD3","ENSG00000136636","","CDC42 GTPase cycle","",78,96.6,103.5,203.7,200.9,316.9,0.38544698544698547,-1.3753956500318736,0.01920866869870552,1.7165027338807022,0.14444049333213851,0.8403110369230037,972]
["Q9Y5A7","NEDD8 ultimate buster 1 [OS=Homo sapiens]",25,15,24,15,615,70.5,5.96,68.07,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus","","NUB1","ENSG00000013374","","","",3045.5,3158.5,3223.6,3527.5,3518,3302.6,0.9110464722992626,-0.1344034473960729,0.027044081924356523,1.567927757130163,0.17054805417180485,0.7681532312097862,1159]
["Q9Y5A9-1","YTH domain-containing family protein 2 [OS=Homo sapiens]",16,9,24,6,579,62.3,8.79,62.04,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity","YTHDF2","ENSCSAG00000001018; ENSG00000198492; ENSMFAG00000026128; ENSMMUG00000011391; ENSMNEG00000041161; ENSNLEG00000009856; ENSPTRG00000000439; ENSRBIG00000043898; ENSRROG00000038863","","","",1033.3,1019.1,1128,1897.1,1811.7,1087.1,0.6631497737650911,-0.5925933520525226,0.10633262063061186,0.9733334825455202,0.3360074034540173,0.4736511534321667,2313]
["Q9Y5B0","RNA polymerase II subunit A C-terminal domain phosphatase [OS=Homo sapiens]",12,10,17,10,961,104.3,5.27,44.42,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","CTDP1","ENSG00000060069","","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat","",1152.9,1118.6,1151.8,1329.1,1355.8,2080.4,0.7183807944935263,-0.4771793139331894,0.14358244345076504,0.8428986602231824,0.3814773097715891,0.418531288728893,2751]
["Q9Y5B6","PAX3- and PAX7-binding protein 1 [OS=Homo sapiens]",14,11,23,11,917,104.7,5.68,71.3,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus","nucleic acid binding activity","PAXBP1","ENSG00000159086; ENSG00000263141","","","",2551.6,2510.1,2463.3,2689.1,2771.9,1931.6,1.0179098016935855,0.02560972800042097,0.8774495830553796,0.056777828058583966,0.9206544649083791,0.0359033362968285,6966]
["Q9Y5B8","Nucleoside diphosphate kinase 7 [OS=Homo sapiens]",11,4,5,4,376,42.5,6.47,11.96,"other metabolic processes","cytosol;cytoskeleton","kinase activity;other molecular function","NME7","ENSG00000143156","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors","Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes","Pyrimidine metabolism; Ciliopathies",408.6,388.1,400.6,407.5,395.5,324.7,1.0617185421654696,0.08640136346825487,0.43094938651952297,0.36557373319433806,0.6013381187612052,0.22088126539957847,5238]
["Q9Y5B9","FACT complex subunit SPT16 [OS=Homo sapiens]",41,44,216,44,1047,119.8,5.66,598.2,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus","other molecular function","SUPT16H","ENSG00000092201","","Regulation of TP53 Activity through Phosphorylation; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes","",30753.9,30707.8,30137.7,26839.8,27284.2,20747.8,1.2234165600399616,0.2909157094912583,0.058022157051247455,1.2364061297553397,0.24713516660114665,0.6070654513840534,1716]
["Q9Y5J1","U3 small nucleolar RNA-associated protein 18 homolog [OS=Homo sapiens]",23,8,18,8,556,62,8.76,49.37,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","","UTP18","ENSG00000011260","Ribosome biogenesis in eukaryotes","rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol","",924.4,898.1,886.3,1495.9,1639.9,1342.2,0.6049129075480125,-0.7252006498443182,2.439287510636272E-3,2.612737007835566,0.05536879632062271,1.256734917647424,322]
["Q9Y5J6","Mitochondrial import inner membrane translocase subunit Tim10 B [OS=Homo sapiens]",24,1,1,1,103,11.6,7.43,2.04,"cell adhesion;cell organization and biogenesis;transport","other membranes;mitochondrion","transporter activity;other molecular function","TIMM10B","ENSG00000132286","","Mitochondrial protein import","",52.3,62.7,60.8,47.6,58.8,23,1.3585780525502318,0.4420974531508965,0.2340443647802092,0.6307018111668414,0.4799748210377523,0.3187815446477057,3564]
["Q9Y5J9","mitochondrial import inner membrane translocase subunit Tim8 B [OS=Homo sapiens]",13,1,2,1,83,9.3,5.12,3.6,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","TIMM8B","ENSG00000150779","","Mitochondrial protein import","",169.5,173.8,181.9,156.4,221.5,417.9,0.6599648152802213,-0.5995389828008503,0.31554293797801025,0.5009415351263519,0.53722416344777,0.2698444617218177,4293]
["Q9Y5K5-1","Ubiquitin carboxyl-terminal hydrolase isozyme L5 [OS=Homo sapiens]",61,15,80,1,329,37.6,5.33,271.77,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","UCHL5","ENSCANG00000036448; ENSCATG00000035323; ENSG00000116750; ENSGGOG00000004347; ENSMFAG00000038349; ENSMLEG00000030039; ENSMNEG00000039813; ENSPPAG00000029294; ENSPTRG00000001793","","UCH proteinases; Downregulation of TGF-beta receptor signaling","TGF-beta signaling pathway",176.1,146.6,175.4,204.5,189.6,173.9,0.8769366197183098,-0.1894555187194572,0.15073129117305456,0.8217965806440779,0.3891540117216022,0.40987848812520794,2831]
["Q9Y5K5-3","Isoform 3 of Ubiquitin carboxyl-terminal hydrolase isozyme L5 [OS=Homo sapiens]",61,15,82,1,328,37.5,5.4,278.15,"","","","UCHL5","","","","",8836.7,8666.9,8878.8,8897.7,8331.1,9127.4,1.000994073500732,1.4334325591066966E-3,0.9733087429736369,0.011749375455247284,0.9833997238587658,0.007269917996875246,7234]
["Q9Y5K6","CD2-associated protein [OS=Homo sapiens]",41,23,57,23,639,71.4,6.4,150.5,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","CD2AP","ENSG00000198087","Bacterial invasion of epithelial cells","Nephrin family interactions","Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome; Genes controlling nephrogenesis",6676.4,6540.7,6469.1,7636.1,8096.1,4549.7,0.9706289844639799,-0.04300815306456367,0.8673186245326734,0.06182132760377387,0.9136972941350979,0.03919766122584195,6938]
["Q9Y5K8","V-type proton ATPase subunit D [OS=Homo sapiens]",39,11,36,11,247,28.2,9.36,101.86,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol","transporter activity","ATP6V1D","ENSG00000100554","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis","Neutrophil degranulation; Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Proximal tubule transport",3869.2,3778.2,3830.5,3850.9,3964.1,3413.4,1.022220441024545,0.0317063458636804,0.6502431640760014,0.1869242047909541,0.7524742378453917,0.12350836424323774,6316]
["Q9Y5L0-2","transportin-3 [OS=Homo sapiens]",31,23,71,23,923,104.1,5.57,225.81,"transport","other membranes;nucleus;other cell component","other molecular function","TNPO3","ENSCANG00000033070; ENSCATG00000030018; ENSG00000064419; ENSGGOG00000008339; ENSMLEG00000037881; ENSMMUG00000004311; ENSMNEG00000045277; ENSPPAG00000034975; ENSPPYG00000017990; ENSPTRG00000019676","Nucleocytoplasmic transport","","",6984.3,7150.5,7018.6,7307.7,7200.5,6476.4,1.0080439941671513,0.011558603899078998,0.8427824178774979,0.07428453321869713,0.8942939448703009,0.04851970978032246,6888]
["Q9Y5M8","signal recognition particle receptor subunit beta [OS=Homo sapiens]",50,11,82,11,271,29.7,9.04,282.32,"transport","other membranes;cytoskeleton;ER/Golgi;other cell component","other molecular function","SRPRB","ENSG00000144867","Protein export","XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane","",9241.9,9244.1,9625.4,8627.2,9191.7,9045.2,1.0464299939324229,0.06547579866021665,0.12110931056468263,0.9168224681580771,0.35379214664958647,0.45125181163150524,2502]
["Q9Y5N5","HemK methyltransferase family member 2 [OS=Homo sapiens]",24,5,9,5,214,22.9,5.11,21.42,"protein metabolism;DNA metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","N6AMT1","ENSG00000156239","","Eukaryotic Translation Termination; Methylation","",803.7,815,822.4,792.9,870.4,1349,0.8103774524449755,-0.3033340610473647,0.33526793465905147,0.47460798091818684,0.5475918065749736,0.2615430586861447,4475]
["Q9Y5N6","Origin recognition complex subunit 6 [OS=Homo sapiens]",7,1,1,1,252,28.1,8.66,2.55,"DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","ORC6","ENSG00000091651","Cell cycle","Assembly of the ORC complex at the origin of replication; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation","Cell cycle; G1 to S cell cycle control; DNA replication",66.1,75.1,76.4,95.5,93.2,97.6,0.760041914076144,-0.39584911374901344,2.7574709464326984E-3,2.559489054724737,0.058418420717323456,1.233450187914038,345]
["Q9Y5P4-1","Collagen type IV alpha-3-binding protein [OS=Homo sapiens]",24,14,34,14,624,70.8,5.48,79.24,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus","transporter activity;kinase activity;other molecular function","CERT1","ENSG00000113163; ENSPTRG00000016996","","","Sphingolipid pathway",2969.1,2866.9,2951.7,3195.8,3106.1,2711.5,0.974959504737391,-0.03658579759211265,0.6467272866328939,0.18927881497047092,0.7507829952350416,0.1244855724375061,6296]
["Q9Y5P6","Mannose-1-phosphate guanyltransferase beta [OS=Homo sapiens]",45,11,38,11,360,39.8,6.61,132.58,"other metabolic processes","other cell component","other molecular function","GMPPB","ENSG00000173540","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars","Synthesis of GDP-mannose","",3956.1,3979.6,4136.1,4114.9,3863.4,3937.3,1.013108865688677,0.01878921022026895,0.6076794818728886,0.21632542723639098,0.7237297267409064,0.14042358863634985,6137]
["Q9Y5Q8-1","general transcription factor 3C polypeptide 5 [OS=Homo sapiens]",23,10,18,10,519,59.5,6.9,39.12,"RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","nucleic acid binding activity","GTF3C5","ENSG00000148308","","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter","",1281.3,1254.3,1261.5,1287.4,1269,1408.4,0.9577027845036319,-0.062350098478938305,0.2770704868839206,0.5574097321249377,0.5116493654963556,0.29102756011134223,3958]
["Q9Y5Q9","General transcription factor 3C polypeptide 3 [OS=Homo sapiens]",23,14,28,14,886,101.2,5.07,89.01,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","nucleic acid binding activity","GTF3C3","ENSG00000119041","","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter","",1513.1,1639,1571.5,1570.2,1521.3,1454.1,1.0391587469200987,0.055416064155628844,0.29728985041385253,0.5268199175172298,0.5243464084640077,0.2803817023704335,4144]
["Q9Y5R8","trafficking protein particle complex subunit 1 [OS=Homo sapiens]",4,1,1,1,145,16.8,9.16,1.79,"transport","non-structural extracellular;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","TRAPPC1","ENSG00000170043","","Neutrophil degranulation; COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs","",71.8,72.2,88.4,68.9,89.6,53.9,1.0941619585687383,0.12982630260037537,0.5994403512915643,0.2222540258991733,0.7175416848329583,0.14415286397784333,6106]
["Q9Y5S1","Transient receptor potential cation channel subfamily V member 2 [OS=Homo sapiens]",17,7,12,7,764,85.9,5.83,30.85,"cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","transporter activity","TRPV2","ENSG00000187688","NOD-like receptor signaling pathway; Inflammatory mediator regulation of TRP channels","TRP channels","",888.7,909.6,972.8,936.5,977.1,2221.9,0.6700761697497281,-0.5776029941315795,0.34244104651294416,0.46541418439890914,0.5505722852976482,0.2591856539038882,4546]
["Q9Y5S2","Serine/threonine-protein kinase MRCK beta [OS=Homo sapiens]",3,4,5,4,1711,194.2,6.37,8.61,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","kinase activity;other molecular function","CDC42BPB","ENSG00000198752","","CDC42 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle","VEGFA-VEGFR2 signaling pathway",1003.8,1589.8,1049.3,769.1,636.6,212.7,2.250926841324765,1.1705191676880522,0.05544055288760238,1.2561724473205367,0.24264371320687772,0.615030956584147,1670]
["Q9Y5S9","RNA-binding protein 8A [OS=Homo sapiens]",47,7,39,1,174,19.9,5.72,112.15,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","RBM8A","ENSG00000265241","Nucleocytoplasmic transport; mRNA surveillance pathway; Spliceosome","Regulation of expression of SLITs and ROBOs; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); RNA Polymerase II Transcription Termination; mRNA 3'-end processing; Transport of Mature mRNA derived from an Intron-Containing Transcript","",1613.2,1217.2,1091,1846.1,1465,3052.4,0.61623320499725,-0.6984516725000389,0.18133163431078012,0.7415264242103226,0.4249287961453966,0.3716838370834933,3119]
["Q9Y5S9-2","Isoform 2 of RNA-binding protein 8A [OS=Homo sapiens]",47,7,32,1,173,19.7,5.92,94.61,"","","","RBM8A","","","","",3193.9,2514.2,2199.6,3466.6,2847,2293.7,0.9187201561465268,-0.1223026140278267,0.6302969644823893,0.2004547844366927,0.739935835753579,0.1308059388992162,6226]
["Q9Y5T5-2","Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 16 [OS=Homo sapiens]",23,13,22,13,822,93.4,6.93,70.14,"","","","USP16","","","","",1530.3,1582.5,1608.1,1776.4,1733.1,2003,0.8563990929705215,-0.22364482715042228,0.038356139056777,1.4161651155453476,0.2037391136380691,0.6909255875608672,1376]
["Q9Y5U2-1","Protein TSSC4 [OS=Homo sapiens]",13,4,9,4,329,34.3,5.19,23.79,"","","","TSSC4","ENSG00000184281","","","",698.3,678.4,681.7,775.7,803,1294,0.7165384481498241,-0.4808839759311704,0.1825238019072053,0.7386804936024042,0.4258111931502596,0.3707829266001364,3133]
["Q9Y5U8","Mitochondrial pyruvate carrier 1 [OS=Homo sapiens]",27,2,4,2,109,12.3,9.61,11.35,"transport","other membranes;mitochondrion","transporter activity","MPC1","ENSG00000060762","Diabetic cardiomyopathy","Pyruvate metabolism","Glycolysis and gluconeogenesis",473.3,513.9,414.9,385.6,313,619.3,1.0638895212079822,0.08934834305639378,0.7862075760257248,0.10446277556259155,0.8566474617131817,0.06719786761266665,6708]
["Q9Y5U9","immediate early response 3-interacting protein 1 [OS=Homo sapiens]",24,1,9,1,82,9,8.22,48,"transport;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","","IER3IP1","ENSG00000134049","","","",1032,1054.1,1066.3,762.7,929.2,355.5,{"$f":"AVERAGE(S7234:U7234)/AVERAGE(V7234:X7234)","v":1.5397088990915306},{"$f":"LOG(Y7234,2)","v":0.6226576174560355},{"$f":"TTEST(V7234:X7234,S7234:U7234,2,2)","v":0.09712729657137342},1.0126586991924906,{"$f":"AA7234*7309/AE7234","v":0.32078780417540365},0.49378215123577557,2213]
["Q9Y5W8","Sorting nexin-13 [OS=Homo sapiens]",4,3,3,3,968,112.1,6.58,8.65,"transport;other biological processes","other membranes;other cytoplasmic organelle","other molecular function","SNX13","ENSG00000071189","","","",135,156.9,154,170.2,173.9,246.2,0.7553786210401491,-0.40472814213366215,0.13410143072309097,{"$f":"-LOG10(AA7235)","v":0.8725665886522869},0.3712679383163151,{"$f":"-LOG10(AC7235)","v":0.43031255363814497},2640]
["Q9Y5W9","Sorting nexin-11 [OS=Homo sapiens]",5,1,1,1,270,30.4,7.05,3.13,"cell organization and biogenesis;transport","other membranes;other cytoplasmic organelle","other molecular function","SNX11","ENSG00000002919","","","",67.6,51.3,61.6,62.3,59.7,130.6,0.7145684877276326,-0.48485580201301903,0.367816268912926,0.4343690653566399,0.5615978921003919,0.2505745309546155,4787]
["Q9Y5X2","Sorting nexin-8 [OS=Homo sapiens]",15,6,8,6,465,52.5,7.39,23.67,"transport","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","SNX8","ENSG00000106266","","","",605.7,614.4,639.1,600.9,604.8,1394.9,0.7149119433976774,-0.4841625406144233,0.4025510228404532,0.3951790655229658,0.5823922062432447,0.23478444552228597,5052]
["Q9Y5X3","sorting nexin-5 [OS=Homo sapiens]",45,16,60,15,404,46.8,6.76,184.77,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","SNX5","ENSG00000089006","Endocytosis","Golgi Associated Vesicle Biogenesis","",8061.5,7868.3,7872.2,8027.7,7461.4,3522,1.252005407367275,0.3242407932330756,0.3231937225162786,0.4905370832409443,0.542914943201903,0.26526820464968837,4351]
["Q9Y5Y0","Feline leukemia virus subgroup C receptor-related protein 1 [OS=Homo sapiens]",2,1,1,1,555,59.8,5.97,3.04,"other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion","transporter activity;other molecular function","FLVCR1","ENSG00000162769","","","",170.1,165.4,198.1,199.4,222.3,293.4,0.7461893441476717,-0.4223863367898619,0.11466465419383548,0.9405704343590219,0.34560163195989424,0.46142421541333134,2425]
["Q9Y5Y2","Cytosolic Fe-S cluster assembly factor NUBP2 [OS=Homo sapiens]",42,8,17,8,271,28.8,5.83,54.52,"cell organization and biogenesis;other metabolic processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","NUBP2","ENSG00000095906","","Cytosolic iron-sulfur cluster assembly","",2006.7,1969.3,2036.4,1820.8,1755.8,2313.3,1.0207983157608786,0.029697853880944505,0.828935968764893,0.08147901527129515,0.8837066796532383,0.05369186230246398,6856]
["Q9Y5Y5","Peroxisomal membrane protein PEX16 [OS=Homo sapiens]",15,3,8,3,336,38.6,9.85,31.89,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","other molecular function","PEX16","ENSG00000121680","Peroxisome","Class I peroxisomal membrane protein import","",568.8,570.3,706,905.4,593.5,1253.7,0.6703117052968102,-0.5770959678065104,0.19767026566106352,0.7040586540577042,0.4444084809956054,0.3522176616698579,3251]
["Q9Y5Y6","suppressor of tumorigenicity 14 protein [OS=Homo sapiens]",20,16,31,16,855,94.7,6.55,89.97,"protein metabolism;developmental processes","non-structural extracellular;plasma membrane;other membranes","other molecular function","ST14","ENSG00000149418","MicroRNAs in cancer","Formation of the cornified envelope","",2752.4,3367,2668,3261.2,3742.2,4199.6,0.7843791841471034,-0.35037684508680406,0.08239350995412667,1.0841069958528335,0.29361977779361864,0.5322146943372269,2051]
["Q9Y5Z7","host cell factor 2 [OS=Homo sapiens]",11,7,15,6,792,86.7,8.48,42.05,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","HCFC2","ENSG00000111727","Herpes simplex virus 1 infection","","",915.5,980.6,943.3,1041.4,1061.4,1913.2,0.7070219123505975,-0.5001731664868376,0.24483296933771173,0.6111301002628524,0.48759786727229837,0.3119382026309688,3670]
["Q9Y5Z9-1","UbiA prenyltransferase domain-containing protein 1 [OS=Homo sapiens]",8,2,3,2,338,36.8,8.15,6.32,"other metabolic processes;other biological processes","other membranes;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","UBIAD1","ENSG00000120942; ENSGGOG00000001270","","Metabolism of vitamin K","7q11.23 copy number variation syndrome",104.6,121.4,116.4,118.8,131.8,200.7,0.7586970972745402,-0.3984040768113405,0.2336049647158411,0.6315179315691332,0.48015148681329656,0.3186217219833363,3556]
["Q9Y606","tRNA pseudouridine synthase A [OS=Homo sapiens]",36,15,26,15,427,47.4,8.41,75.22,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","PUS1","ENSG00000177192","","","",2440.6,2347.2,2355.3,2236.3,2178.9,2185.3,1.082205893492917,0.11397500310446151,0.006637073708431787,2.178023359246997,0.08740607519806834,1.0584583804857002,555]
["Q9Y608","Leucine-rich repeat flightless-interacting protein 2 [OS=Homo sapiens]",5,3,11,2,721,82.1,6.95,36.04,"cell-cell signaling;signal transduction;other biological processes","","other molecular function","LRRFIP2","ENSG00000093167","","","VEGFA-VEGFR2 signaling pathway; Genotoxicity pathway",385.5,491.7,317.1,429.2,512.2,243.6,1.007848101265823,0.011278218139522102,0.9753393858181145,0.010844237900377448,0.984906821075518,0.006604854788585015,7238]
["Q9Y613","FH1/FH2 domain-containing protein 1 [OS=Homo sapiens]",38,33,92,33,1164,126.5,6.39,245.41,"cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","FHOD1","ENSG00000135723","Salmonella infection","","VEGFA-VEGFR2 signaling pathway",6084.6,5780.5,6187.7,6514.9,6516.3,8005.6,0.8581533313051413,-0.22069264931884794,0.12371322147646595,0.9075838839809793,0.357399184099403,0.44684644327282425,2530]
["Q9Y617-1","phosphoserine aminotransferase [OS=Homo sapiens]",65,21,89,20,370,40.4,7.66,269.38,"other metabolic processes","cytosol;other cell component","other molecular function","PSAT1","ENSG00000135069; ENSGGOG00000015480; ENSPPAG00000036829; ENSPTRG00000021045","Glycine, serine and threonine metabolism; Cysteine and methionine metabolism; Vitamin B6 metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; Biosynthesis of cofactors","Serine biosynthesis","Trans-sulfuration and one-carbon metabolism; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Male infertility; Neuroinflammation and glutamatergic signaling",11773.1,11987.7,11225.8,15848.9,15281.6,15400.3,0.7519019660096109,-0.4113835212444159,1.7439699684787161E-4,3.7584609979792964,0.017703717360570744,1.751935532526592,72]
["Q9Y619","mitochondrial ornithine transporter 1 [OS=Homo sapiens]",5,2,2,2,301,32.7,9.13,2.12,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","SLC25A15","ENSG00000102743","","Urea cycle","",67,65,77.1,55,55.8,200.5,0.6716993254095728,-0.5741125148796004,0.5212471660294299,0.2829562932289799,0.6645378574060881,0.17748027311968226,5733]
["Q9Y624","Junctional adhesion molecule A [OS=Homo sapiens]",51,12,52,12,299,32.6,7.9,148.06,"cell adhesion;cell organization and biogenesis;stress response;transport;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","F11R","ENSG00000158769","Cell adhesion molecules; Tight junction; Leukocyte transendothelial migration; Epithelial cell signaling in Helicobacter pylori infection","Integrin cell surface interactions; Cell surface interactions at the vascular wall; Tight junction interactions; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)","1q21.1 copy number variation syndrome",6598.8,6565.8,6963.6,5188.2,5535.4,5637.2,1.2302699134516653,0.29897486847411253,2.52571748723071E-3,2.5976152288394507,0.05594081549748261,1.2522712068333655,330]
["Q9Y639-1","Isoform 1 of Neuroplastin [OS=Homo sapiens]",11,3,5,3,282,31.3,6.87,17.58,"","","","NPTN","","","","",866.1,861.4,870.5,973.3,1006.2,1224.5,0.8108614232209738,-0.30247271696082906,0.06255585849580207,1.2037320114181216,0.2535888905966818,0.5958697762565505,1803]
["Q9Y657","Spindlin-1 [OS=Homo sapiens]",37,7,7,5,262,29.6,6.96,20.32,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;signal transduction;other biological processes","other membranes;cytosol;nucleus","other molecular function","SPIN1","ENSG00000106723","","","",364.2,388.6,364.7,406.6,441.5,824.5,0.6681214875044841,-0.581817636672655,0.23976755074494682,0.6202095930719662,0.4829046647547028,0.3161385993885497,3629]
["Q9Y666","Solute carrier family 12 member 7 [OS=Homo sapiens]",8,8,13,7,1083,119,6.71,26.59,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;other cell component","transporter activity;other molecular function","SLC12A7","ENSG00000113504","Collecting duct acid secretion","Cation-coupled Chloride cotransporters","",543.4,561.4,573.8,513.3,557.1,880.5,0.8604233943308215,-0.21688134368958578,0.47812092754607727,0.3204622466433242,0.6335362326748148,0.19822854226316336,5516]
["Q9Y672","Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase [OS=Homo sapiens]",10,5,17,5,507,58.1,8.46,38.32,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","ALG6","ENSG00000088035","N-Glycan biosynthesis; Metabolic pathways","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG6 causes CDG-1c","GPCRs, other",2054.1,1994.7,2063.7,1533.1,1630.4,1181.4,1.406821791065387,0.492439586975551,0.012977118632255195,1.8868217251800554,0.1191579900542126,0.9238768310337515,796]
["Q9Y673","dolichyl-phosphate beta-glucosyltransferase [OS=Homo sapiens]",37,13,32,13,324,36.9,9.28,77.45,"protein metabolism;other metabolic processes;developmental processes","other membranes;ER/Golgi","other molecular function","ALG5","ENSG00000120697","N-Glycan biosynthesis; Metabolic pathways","Synthesis of dolichyl-phosphate-glucose","",3299.1,3420.9,3309.7,2769.5,2689.6,1998.1,1.3449686209301077,0.42757251407809815,0.025867558911227006,1.5872445531700026,0.16687201066386423,0.7776165011494269,1133]
["Q9Y676","28S ribosomal protein S18b, mitochondrial [OS=Homo sapiens]",17,3,6,3,258,29.4,9.38,16.02,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus;other cell component","other molecular function","MRPS18B","ENSG00000203624; ENSG00000204568; ENSG00000223775; ENSG00000226111; ENSG00000227420; ENSG00000229861; ENSG00000233813","Viral carcinogenesis","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",211.4,194.4,219.4,191.5,178.6,205.2,1.086737354423779,0.12000330811542599,0.19319026238114181,0.7140147676757788,0.4393365363235114,0.3572026782191315,3214]
["Q9Y678","Coatomer subunit gamma-1 [OS=Homo sapiens]",67,46,229,42,874,97.7,5.47,675.39,"transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","COPG1","ENSG00000181789","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport","VEGFA-VEGFR2 signaling pathway",22058.4,22337,22670.9,22028.2,21004.3,20110,1.062141980441066,0.08697662940678254,0.08781476559208465,1.0564324536154193,0.3039006258108649,0.517268405593221,2112]
["Q9Y679-1","Ancient ubiquitous protein 1 [OS=Homo sapiens]",13,6,16,6,476,53,8.09,46.26,"","","","","","","","",1677.5,1666.6,1771.6,1504.1,1496.8,2531.5,0.924680066517244,-0.11297380632794977,0.7080640054456185,0.149927482486161,0.7943576079511936,0.0999839406507915,6515]
["Q9Y689-1","ADP-ribosylation factor-like protein 5A [OS=Homo sapiens]",4,1,1,1,179,20.7,6.79,2.51,"transport;other biological processes","ER/Golgi","other molecular function","ARL5A; LOC111161526","ENSAMEG00000008735; ENSANAG00000027698; ENSCANG00000029546; ENSCATG00000029667; ENSCCAG00000023321; ENSCJAG00000040846; ENSECAG00000023672; ENSFCAG00000014742; ENSG00000162980; ENSGGOG00000002066; ENSLCNG00005010847; ENSMMUG00000010521; ENSMNEG00000035230; ENSMPUG00000000396; ENSNVIG00000004853; ENSOCUG00000035346; ENSOGAG00000011424; ENSPANG00000009772; ENSPPAG00000033494; ENSPTRG00000012538; ENSRBIG00000031831; ENSRFEG00010001991; ENSRROG00000040290; ENSSBOG00000034323; ENSSSCG00000031541; ENSSSCG00070004184; ENSSSUG00005001466","","","",44.6,50.5,50.3,40.5,34.5,84.8,0.9098873591989985,-0.13624013900838275,0.7788419344519629,0.1085506732141564,0.8505237858821749,0.07031353633368362,6693]
["Q9Y692-1","Glucocorticoid modulatory element-binding protein 1 [OS=Homo sapiens]",8,4,8,4,573,62.6,4.83,26.33,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","GMEB1","ENSG00000162419; ENSGGOG00000009221; ENSPPAG00000038756","","","",293.3,276.5,300.3,328.5,354.8,419.1,0.7892779390420899,-0.3413946695942025,0.04965265621888387,1.3040575135261538,0.22853354175303667,0.6410500497332584,1588]
["Q9Y696","Chloride intracellular channel protein 4 [OS=Homo sapiens]",74,15,147,13,253,28.8,5.59,511.58,"transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","transporter activity","CLIC4","ENSG00000169504","","","",12994.3,14107.1,12890.2,13157.6,13710.3,10461.1,1.0713279219909455,0.09940014116999862,0.45604699623522016,0.34099040041902745,0.6185280192026766,0.2086406221310799,5389]
["Q9Y697","Cysteine desulfurase, mitochondrial [OS=Homo sapiens]",48,15,40,15,457,50.2,8.31,118.05,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytosol;mitochondrion;nucleus","other molecular function","NFS1","ENSG00000244005","Thiamine metabolism; Metabolic pathways; Biosynthesis of cofactors; Sulfur relay system","","",3008,3005.2,3203.8,2905,2766.2,3445.4,1.0110128776078802,0.01580137344538527,0.8850888953230095,0.053013108048592904,0.9261438419349859,0.03332155661482065,6985]
["Q9Y6A4","Cilia- and flagella-associated protein 20 [OS=Homo sapiens]",38,7,19,7,193,22.8,9.76,47.39,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","","CFAP20","ENSG00000070761","","","",2390.1,2356.2,2337.9,2314.3,1875.6,1614.5,1.22048790572669,0.2874579989825831,0.1055943751386279,0.9763592154321088,0.33556055995140494,0.47422908956572873,2300]
["Q9Y6A5","Transforming acidic coiled-coil-containing protein 3 [OS=Homo sapiens]",32,22,51,22,838,90.3,5.05,162.76,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","","TACC3","ENSG00000013810","","Negative regulation of NOTCH4 signaling; NOTCH3 Activation and Transmission of Signal to the Nucleus","",4431.7,4624.1,4120.1,4256.7,4354.1,6058.6,0.8981894283338104,-0.15490835315302198,0.45558177280040946,0.34143365976974627,0.6181264483753839,0.20892267343172818,5387]
["Q9Y6A9","Signal peptidase complex subunit 1 [OS=Homo sapiens]",17,2,7,2,102,11.8,9.31,25.02,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","translation activity;other molecular function","SPCS1","ENSG00000114902","Protein export","","",1051.4,1065.9,1098.7,926.9,1087.6,853.2,1.121456219269798,0.16537329989343735,0.1754314983504117,0.7558924273232766,0.41671394912029863,0.38016196168676203,3077]
["Q9Y6B6","GTP-binding protein SAR1b [OS=Homo sapiens]",47,8,65,4,198,22.4,6.11,172.63,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","SAR1B","ENSG00000152700","Protein processing in endoplasmic reticulum; Legionellosis","MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Chylomicron assembly","Sterol regulatory element-binding proteins (SREBP) signaling",2142.8,2185.4,2099.3,1919.2,1980,1847.4,1.1184874534507363,0.1615490731641976,7.6571622781084585E-3,2.115932148813045,0.09220131645913464,1.0352628780043296,607]
["Q9Y6B7","AP-4 complex subunit beta-1 [OS=Homo sapiens]",5,5,8,5,739,83.2,5.86,15.67,"transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","other molecular function","AP4B1","ENSG00000134262","Lysosome","Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis","",548.9,545.4,545.3,516,580.7,489.9,1.0334047649060885,0.04740544098547072,0.5488374285141959,0.2605562791473221,0.6837315092909934,0.16511440547968076,5867]
["Q9Y6C2","EMILIN-1 [OS=Homo sapiens]",4,3,3,3,1016,106.6,5.15,9.3,"","","","","","","","",340.4,313.8,326.5,477.6,481,684.7,0.5967869530822125,-0.7447120990551701,0.03272998947517313,1.4850541343459818,0.18762626907767876,0.7267063572319828,1275]
["Q9Y6C9","Mitochondrial carrier homolog 2 [OS=Homo sapiens]",45,12,36,12,303,33.3,7.97,143.4,"other biological processes","other membranes;mitochondrion","","MTCH2","ENSG00000109919; ENSG00000285121","","","",4854.6,4946.8,5382.9,5305.7,4488.1,6752.8,0.9176688866594951,-0.1239544006655204,0.5418796471592748,0.2660971606547311,0.6798143393558428,0.1676096790624066,5826]
["Q9Y6D0","selenoprotein K [OS=Homo sapiens]",10,1,2,1,94,10.6,10.86,4.11,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi","other molecular function","SELENOK","ENSG00000113811","","","Selenium micronutrient network",99.5,177.1,95.7,154.8,207.7,57.5,0.8864285714285715,-0.17392371170197213,0.772352859039378,0.1121842414745292,0.8458386345098613,0.07271248190933013,6674]
["Q9Y6D5","Brefeldin A-inhibited guanine nucleotide-exchange protein 2 [OS=Homo sapiens]",29,43,115,33,1785,201.9,6.33,337.73,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","ARFGEF2","ENSG00000124198","Endocytosis","Association of TriC/CCT with target proteins during biosynthesis","",9868.8,9837.4,10115.1,9717.7,9331.1,9292.4,1.0522243235995652,0.07344230543326986,0.037981698334107764,1.4204256198875487,0.20307844412874446,0.6923361725713978,1367]
["Q9Y6D6","Brefeldin A-inhibited guanine nucleotide-exchange protein 1 [OS=Homo sapiens]",21,30,54,20,1849,208.6,5.85,148.05,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","ARFGEF1","ENSG00000066777","Endocytosis","","",2101.6,2083.6,2138.2,2356.2,2376,1933.4,0.9486617858857416,-0.07603426137596339,0.47614093713550215,0.3222644776144423,0.632173316897981,0.19916383903823995,5505]
["Q9Y6D9","mitotic spindle assembly checkpoint protein MAD1 [OS=Homo sapiens]",30,21,46,21,718,83,5.92,141.24,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","MAD1L1","ENSG00000002822","Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection; Viral carcinogenesis","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; Malignant pleural mesothelioma; CCL18 signaling pathway",5168.5,5011.8,5037,5338.1,5330,5061.8,0.9674123802439939,-0.047797094417697826,0.17235048341469575,0.7635874941298926,0.4143781852888195,0.3826031158546733,3040]
["Q9Y6E0","Serine/threonine-protein kinase 24 [OS=Homo sapiens]",44,16,82,9,443,49.3,5.69,238.94,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","STK24","ENSG00000102572","","Apoptotic cleavage of cellular proteins","",3595.8,3610.4,3766.7,4121.6,3869.7,5162.4,0.8342063449827806,-0.2615238094638923,0.14288101928652752,0.8450254602686907,0.38099867565313006,0.4190765339242163,2741]
["Q9Y6E2","Basic leucine zipper and W2 domain-containing protein 2 [OS=Homo sapiens]",43,20,98,16,419,48.1,6.68,245.56,"developmental processes;other biological processes","other cell component","","BZW2","ENSG00000136261","","","",8192.9,7943.9,8306.3,7724.9,7336.2,6070.7,1.1566974890922685,0.21001160597410884,0.09676223340671895,1.0142941160747319,0.3200159112985108,0.4948284278758695,2210]
["Q9Y6G1","Transmembrane protein 14A [OS=Homo sapiens]",6,1,1,1,99,10.7,10.55,0,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion;ER/Golgi","","TMEM14A","ENSG00000096092","","","",34.8,59.3,53.8,46.5,23.5,35.4,1.4032258064516125,0.48874718546185275,0.2279609761194649,0.6421394920632286,0.47415104566225635,0.32408328733853187,3514]
["Q9Y6G5","COMM domain-containing protein 10 [OS=Homo sapiens]",29,4,8,4,202,23,6.54,19.29,"","nucleus;other cell component","","COMMD10","ENSG00000145781","","Neddylation","",282.3,264.2,289.9,284.1,293,230.9,1.0351485148514852,0.049837768950422245,0.6730920926399806,0.17192551142363513,0.7684520626531737,0.11438321934777573,6402]
["Q9Y6G9","Cytoplasmic dynein 1 light intermediate chain 1 [OS=Homo sapiens]",54,23,68,23,523,56.5,6.42,245.49,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","DYNC1LI1","ENSG00000144635","Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection","Neutrophil degranulation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; MHC class II antigen presentation; COPI-mediated anterograde transport; HCMV Early Events; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy","Ciliary landscape; Intraflagellar transport proteins binding to dynein",9235.6,9288.1,8997.2,8953,9569,7860.4,1.043153769179453,0.060951838280682596,0.49618956842460366,0.3043523703001131,0.6464615963663864,0.18945726967230153,5610]
["Q9Y6H1","Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 [OS=Homo sapiens]",15,2,2,2,151,15.5,9.22,5.96,"cell organization and biogenesis;stress response;other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","CHCHD2","ENSG00000106153","","Mitochondrial protein import","",158.4,182.8,165.2,306.1,312.3,373.5,0.5105353362234096,-0.9699172755472812,2.0478859386939786E-3,2.688694235965391,0.05143642036396663,1.2887292630673255,291]
["Q9Y6H3","Mitochondrial inner membrane protease ATP23 homolog [OS=Homo sapiens]",14,2,2,2,246,28.1,8.03,7.23,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component","kinase activity;other molecular function","ATP23","ENSG00000166896; ENSG00000262145","","","",44.8,54,44.7,55.8,46.9,68.5,0.8382009345794393,-0.25463196483809664,0.25673099038686237,0.5905217038192138,0.49628320781210716,0.3042704192977764,3781]
["Q9Y6I3","epsin-1 [OS=Homo sapiens]",20,10,24,9,576,60.3,4.83,78.69,"transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","EPN1","ENSG00000063245","Endocytosis","Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation","VEGFA-VEGFR2 signaling pathway; EGF/EGFR signaling pathway",2692.2,2786.8,2646,2795.7,2836.8,2571.1,0.9904188405090448,-0.01388933601931724,0.790799464071583,0.10193363368162414,0.8592170778800654,0.06589709948045336,6727]
["Q9Y6I4-1","Ubiquitin carboxyl-terminal hydrolase 3 [OS=Homo sapiens]",10,4,6,4,520,58.9,8.18,22.19,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","USP3","ENSG00000140455","","Ub-specific processing proteases","",452.2,452.3,458.1,496.4,427.7,1107.7,0.6706368737080421,-0.5763962856995629,0.36035642433711856,0.44326773105066036,0.5592027824798301,0.2524306762955835,4710]
["Q9Y6I9","Testis-expressed protein 264 [OS=Homo sapiens]",52,11,32,11,313,34.2,4.86,102.42,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","TEX264","ENSG00000164081","","Platelet degranulation","",2607.9,2561.2,2664.8,2572,3068.2,3293,0.8769421931670622,-0.18944634957183226,0.1636568081372565,0.7860659232924789,0.4049314863490886,0.39261845238443666,2954]
["Q9Y6J0","Calcineurin-binding protein cabin-1 [OS=Homo sapiens]",5,9,12,9,2220,246.2,6.02,36.69,"cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity","CABIN1","ENSG00000099991","","Formation of Senescence-Associated Heterochromatin Foci (SAHF)","",1173.5,1181.8,1119.4,1293.8,1297.2,1434.8,0.8631079536986437,-0.21238707832742726,0.021865406114553145,1.6602424519266468,0.15293229980025735,0.8155007804897467,1045]
["Q9Y6J9","TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L [OS=Homo sapiens]",13,6,8,6,622,67.8,8.97,15.23,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","TAF6L","ENSG00000162227","Basal transcription factors","HATs acetylate histones","",642.7,646.5,637.1,761.6,817,1088.5,0.7222451351655357,-0.46943951364152636,0.07091639900620483,1.1492533251218755,0.2718028108738076,0.5657460562839082,1907]
["Q9Y6K0","Choline/ethanolaminephosphotransferase 1 [OS=Homo sapiens]",1,1,1,1,416,46.5,8.21,1.82,"other metabolic processes","other membranes;ER/Golgi;nucleus","other molecular function","CEPT1","ENSG00000134255","Phosphonate and phosphinate metabolism; Glycerophospholipid metabolism; Ether lipid metabolism; Metabolic pathways","Synthesis of PC; Synthesis of PE","Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways",83.1,81.2,95.9,73.6,76.1,84,1.11339323919555,0.1549632279349704,0.18855185627012153,0.7245691876608942,0.4329643473070431,0.3635478643979243,3183]
["Q9Y6K1","DNA (cytosine-5)-methyltransferase 3A [OS=Homo sapiens]",2,2,3,2,912,101.8,6.57,4.65,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DNMT3A","ENSG00000119772","Cysteine and methionine metabolism; Metabolic pathways; MicroRNAs in cancer","PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; RMTs methylate histone arginines; SUMOylation of DNA methylation proteins","One-carbon metabolism; Trans-sulfuration and one-carbon metabolism; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; One-carbon metabolism and related pathways; MTHFR deficiency",56.7,91.8,95.9,144.3,93.2,2564.1,0.08723586521987436,-3.5189347986148283,0.35483000127627246,0.4499796672002466,0.5567738255320471,0.25432118951493554,4658]
["Q9Y6K5","2'-5'-oligoadenylate synthase 3 [OS=Homo sapiens]",5,6,10,6,1087,121.1,8.4,24.05,"other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","OAS3","ENSG00000111331","NOD-like receptor signaling pathway; Hepatitis C; Measles; Influenza A; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease","Interferon gamma signaling; Interferon alpha/beta signaling; OAS antiviral response","Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction",758.6,834.1,719.7,778.8,717.1,1416.2,0.7940661378386731,-0.3326689203174612,0.4263280718347451,0.3702560700234253,0.5979719587488298,0.22331918130621337,5211]
["Q9Y6K9","NF-kappa-B essential modulator [OS=Homo sapiens]",11,4,4,4,419,48.2,5.71,12.21,"cell organization and biogenesis;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","IKBKG","ENSG00000269335","Antifolate resistance; MAPK signaling pathway; Ras signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; TNF signaling pathway; Adipocytokine signaling pathway; Alcoholic liver disease; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Chagas disease; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Chemical carcinogenesis; Pancreatic cancer; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Primary immunodeficiency; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; TNFR1-induced NFkappaB signaling pathway; activated TAK1 mediates p38 MAPK activation; ER-Phagosome pathway; IKK complex recruitment mediated by RIP1; TICAM1, RIP1-mediated IKK complex recruitment; Regulation of TNFR1 signaling; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Ovarian tumor domain proteases; RIP-mediated NFkB activation via ZBP1; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; SUMOylation of immune response proteins","Nucleotide-binding oligomerization domain (NOD) pathway; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; ATM signaling in development and disease ; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNAs involvement in the immune response in sepsis; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Canonical NF-kB pathway; Cytosolic DNA-sensing pathway; Small cell lung cancer; Hepatitis B infection; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Network map of SARS-CoV-2 signaling pathway; T-cell receptor (TCR) signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway",315.9,587.8,316.5,501.9,591,540.5,0.7470307334394514,-0.42076049702866924,0.2172686329088363,0.6630029682855644,0.463113571866633,0.3343124915165356,3429]
["Q9Y6M1","Insulin-like growth factor 2 mRNA-binding protein 2 [OS=Homo sapiens]",23,13,35,13,599,66.1,8.46,107.13,"transport;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","IGF2BP2","ENSG00000073792","","Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA","",4088.7,3966,4278,4302.3,3808.4,3281.5,1.0825564860167485,0.11444230437014696,0.366839390642951,0.43552403663241346,0.5613963790220539,0.2507303928697531,4776]
["Q9Y6M5","zinc transporter 1 [OS=Homo sapiens]",45,15,58,15,507,55.3,6.48,185.42,"stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","SLC30A1","ENSG00000170385","Mineral absorption","Zinc efflux and compartmentalization by the SLC30 family","Zinc homeostasis",5606.2,5592.9,5872.9,4652.4,4872.3,6217.9,1.0844460254341721,0.11695824962037736,0.42362250271935287,0.3730209783396384,0.5961218468185887,0.22466496174894937,5194]
["Q9Y6M7-7","Isoform 7 of Sodium bicarbonate cotransporter 3 [OS=Homo sapiens]",7,8,12,8,1259,140.7,6.62,35,"","","","SLC4A7","","","","",1031.8,1047.2,1077,1017.8,1068.7,1082.7,0.9958349110185537,-0.006021501987428044,0.8621305476880798,0.06442696637047372,0.9098053960514259,0.041051491699942794,6926]
["Q9Y6M9","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [OS=Homo sapiens]",11,1,1,1,179,21.8,8.38,3.79,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity","NDUFB9","ENSG00000147684","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial immune response to SARS-CoV-2; Oxidative phosphorylation",21.2,27.4,26.1,23.1,29.9,33.1,0.8675958188153309,-0.20490499460760708,0.3387753730452633,0.4700881678197339,0.5489047221431677,0.26050303303347144,4511]
["Q9Y6N1","Cytochrome c oxidase assembly protein COX11, mitochondrial [OS=Homo sapiens]",12,2,10,2,276,31.4,9.06,13.74,"other metabolic processes;other biological processes","other membranes;mitochondrion;other cell component","other molecular function","COX11","ENSG00000166260","Oxidative phosphorylation; Metabolic pathways; Thermogenesis","Cytoprotection by HMOX1; Respiratory electron transport; TP53 Regulates Metabolic Genes","Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis; Mitochondrial complex IV assembly",201.7,212.6,187.5,172.4,203.8,268.9,0.9328786234692296,-0.10023871017714155,0.6484552356119138,0.18811999891335154,0.7517144039789815,0.12394712793847897,6305]
["Q9Y6N5","Sulfide:quinone oxidoreductase, mitochondrial [OS=Homo sapiens]",71,29,161,29,450,49.9,9.11,531.19,"other metabolic processes","other membranes;mitochondrion","other molecular function","SQOR","ENSG00000137767","Sulfur metabolism; Metabolic pathways","Sulfide oxidation to sulfate","",20876.2,20653.8,20121.3,17622.6,17755.9,13034,1.273458301058611,0.34875171984698644,0.04812905060031126,1.3175927051855678,0.2266592982201514,0.6446264602237645,1552]
["Q9Y6N7","Roundabout homolog 1 [OS=Homo sapiens]",4,7,11,6,1651,180.8,6.04,21.23,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","ROBO1","ENSG00000169855","Axon guidance","Regulation of expression of SLITs and ROBOs; Netrin-1 signaling; Regulation of cortical dendrite branching; Regulation of commissural axon pathfinding by SLIT and ROBO; Role of ABL in ROBO-SLIT signaling; Inactivation of CDC42 and RAC1; Activation of RAC1; SLIT2:ROBO1 increases RHOA activity","Development of ureteric collection system",546.7,555.2,557.9,598.1,611.8,959.3,0.765166881799742,-0.3861536630450301,0.22430030669673615,0.6491701325846245,0.4706893315091716,0.3272656451588878,3483]
["Q9Y6P5-2","Isoform T1 of Sestrin-1 [OS=Homo sapiens]",25,13,29,13,551,63.8,6.3,95.15,"","","","SESN1","","","","",2830.8,2803.5,2937.3,3211.2,2917.4,3065.4,0.9323036763106375,-0.1011281389915196,0.0922230881661478,1.0351603391643038,0.31264311289720514,0.504951133795032,2156]
["Q9Y6Q9-1","Nuclear receptor coactivator 3 [OS=Homo sapiens]",3,3,4,3,1424,155.2,7.47,12.25,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","NCOA3","ENSG00000124151","Endocrine resistance; Estrogen signaling pathway; Thyroid hormone signaling pathway; Pathways in cancer; Breast cancer","PPARA activates gene expression; Estrogen-dependent gene expression; Transcriptional regulation of white adipocyte differentiation; MAPK6/MAPK4 signaling; Activation of anterior HOX genes in hindbrain development during early embryogenesis","Androgen receptor signaling pathway; Integrated breast cancer pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Breast cancer pathway; EGF/EGFR signaling pathway",211.7,196.5,215.7,425.3,437.5,519.3,{"$f":"AVERAGE(S7298:U7298)/AVERAGE(V7298:X7298)","v":0.45141451414514144},{"$f":"LOG(Y7298,2)","v":-1.1474752892318152},{"$f":"TTEST(V7298:X7298,S7298:U7298,2,2)","v":1.0988548629490519E-3},2.95905966552266,{"$f":"AA7298*7309/AE7298","v":0.040359448207510654},1.3940547800483938,199]
["Q9Y6R4-1","Mitogen-activated protein kinase kinase kinase 4 [OS=Homo sapiens]",4,5,7,4,1608,181.6,6.32,20.22,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","other cell component","kinase activity;other molecular function","MAP3K4","ENSG00000085511","MAPK signaling pathway; GnRH signaling pathway","","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; EGF/EGFR signaling pathway; Insulin signaling; MAP3K1 role in promoting and blocking gonadal determination; Host-pathogen interaction of human coronaviruses - MAPK signaling; Malignant pleural mesothelioma; G13 signaling pathway; DNA damage response (only ATM dependent)",141.2,142.5,123.6,122.4,128,303.8,0.7349332370985202,-0.4443148964780025,0.45931834450623693,{"$f":"-LOG10(AA7299)","v":0.3378862091461169},0.6200882489833922,{"$f":"-LOG10(AC7299)","v":0.20754649869663158},5414]
["Q9Y6R9","Coiled-coil domain-containing protein 61 [OS=Homo sapiens]",8,5,8,5,512,57.3,10.27,17.7,"cell cycle OR cell proliferation;cell organization and biogenesis","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","CCDC61","ENSG00000104983","","","",396.3,423.5,409.7,539.6,528.9,625.7,0.7257112501475622,-0.46253245967502965,0.008059559303628516,2.0936887047501065,0.09425171032035332,1.0257107602102087,625]
["Q9Y6V0-1","Protein piccolo [OS=Homo sapiens]",0,1,6,1,5065,552.9,6.51,12.09,"","","","","","","","",519.8,531.4,711.6,503.2,483.7,692.5,1.0496605930689529,0.06992290898336452,0.7753347797023841,0.1105107341601929,0.8478339175411018,0.0716892134975737,6684]
["Q9Y6V7","Probable ATP-dependent RNA helicase ddx49 [OS=Homo sapiens]",10,3,4,3,483,54.2,9.06,15.77,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","DDX49","ENSG00000105671","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",296,300.5,284.8,690.1,672.8,426,0.4926491139806584,-1.0213676323687062,0.023979931742244765,1.6201520574343609,0.16035619497169898,0.7949142575000908,1093]
["Q9Y6W3","Calpain-7 [OS=Homo sapiens]",18,12,25,12,813,92.6,7.65,63.85,"protein metabolism;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","CAPN7","ENSG00000131375","","Degradation of the extracellular matrix","Integrin-mediated cell adhesion",2744,2733.3,2656.7,3159.8,3240.7,2513.4,0.9125074322126119,-0.13209178546201716,0.3247972411512293,0.4883876683406101,0.5437340896872046,0.2646134378297575,4366]
["Q9Y6W5","Wiskott-Aldrich syndrome protein family member 2 [OS=Homo sapiens]",24,13,44,12,498,54.3,5.53,115.77,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","WASF2","ENSG00000158195","Adherens junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Yersinia infection; Choline metabolism in cancer","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RAC2 GTPase cycle; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway","Regulation of actin cytoskeleton",5489.5,5409.9,5551.8,5647.1,5771.9,5427.9,0.9765119992402163,-0.0342903230354132,0.2913541164908697,0.5355788414604283,0.5207892485771011,0.2833379901307914,4089]
["Q9Y6X3-1","MAU2 chromatid cohesion factor homolog [OS=Homo sapiens]",7,3,4,3,613,69,7.25,16.13,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MAU2","ENSANAG00000026794; ENSCANG00000033671; ENSCATG00000015302; ENSCCAG00000031923; ENSCSAG00000005122; ENSG00000129933; ENSGGOG00000002989; ENSMFAG00000041829; ENSMNEG00000034232; ENSPPAG00000032359; ENSPTRG00000010738; ENSRBIG00000036077; ENSRROG00000032649; ENSSBOG00000034577","","Cohesin Loading onto Chromatin","Cohesin complex - Cornelia de Lange syndrome",334.5,356.3,355,333.8,303.7,285.3,1.1332899869960988,0.18051706616385854,0.06037789816563655,1.219122009414178,0.2510250612586107,0.600282918267958,1758]
["Q9Y6X4-1","Soluble lamin-associated protein of 75 kDa [OS=Homo sapiens]",6,4,6,4,670,74.9,4.6,19.28,"","other membranes;nucleus","","FAM169A","ENSG00000198780","","RHOF GTPase cycle","",477.6,436.1,519.7,482.1,513.4,352,1.063747680890538,0.08915598665025815,0.6300973686269413,0.20059233405442634,0.7402960403945208,0.130594573513123,6221]
["Q9Y6X5","Bis(5'-adenosyl)-triphosphatase ENPP4 [OS=Homo sapiens]",11,5,11,5,453,51.6,6.15,29.68,"other metabolic processes;stress response;other biological processes","plasma membrane;other membranes","other molecular function","ENPP4","ENSG00000001561","Purine metabolism; Metabolic pathways","Neutrophil degranulation","",920,894.1,887.6,854.5,909,930,1.003044366066456,0.004385419797038479,0.9168097698300376,0.03772076736548645,0.9474003404054496,0.02346646356396057,7073]
["Q9Y6X9-1","MORC family CW-type zinc finger protein 2 [OS=Homo sapiens]",12,12,19,12,1032,117.8,8.38,55.94,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","MORC2","ENSG00000133422","","Fatty acyl-CoA biosynthesis","",2661.3,2562.4,2588,2921,2816.5,2971.2,0.8969995521719659,-0.15682083000976588,0.005325336742860748,2.2736529248014703,0.0810893463616025,1.0910362002930845,480]
["Q9Y6Y0","influenza virus NS1A-binding protein [OS=Homo sapiens]",1,1,1,1,642,71.7,5.53,0,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","","IVNS1ABP","ENSG00000116679","","","",61.5,73.2,67.4,143.5,125.7,55.5,0.6224206960271019,-0.6840380629063528,0.2056950218760278,0.6867762187473402,0.45080207343085077,0.34601409511593495,3335]
["Q9Y6Y8","SEC23-interacting protein [OS=Homo sapiens]",29,26,73,26,1000,111,5.54,187.51,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","SEC23IP","ENSG00000107651","","COPII-mediated vesicle transport","",7294.2,7099.7,7376.4,7629.8,7327.7,8771,0.9174747666308447,-0.12425961492295853,0.2180724260177826,0.6613992449457746,0.4637449408681912,0.33372081519902697,3437]

{"sheet":"F-P","index":3,"n_rows":7310,"n_cols":31,"rows_kept":2250,"cut":true,"bounds":{"rows_first":1000,"rows_last":250,"rows_between":1000,"halvings":1}}
["Accession","Description","Coverage [%]","# Peptides","# PSMs","# Unique Peptides","# AAs","MW [kDa]","calc. pI","Score Sequest HT: Sequest HT","Biological Process","Cellular Component","Molecular Function","Gene Symbol","Ensembl Gene ID","KEGG Pathways","Reactome Pathways","WikiPathways","Abundances (Normalized): F7: 130N, Sample, F-P","Abundances (Normalized): F7: 131N, Sample, F-P","Abundances (Normalized): F7: 132N, Sample, F-P","Abundances (Normalized): F7: 126, Sample, DMSO","Abundances (Normalized): F7: 127C, Sample, DMSO","Abundances (Normalized): F7: 128C, Sample, DMSO","Ratio","log2(Ratio)","P-Value","− log10(P-Value)","q-Value","− log10(q-Value)","Rank (P-Value)"]
["A0A096LP01","Small integral membrane protein 26 [OS=Homo sapiens]",17,1,1,1,95,10.9,6.7,3.05,"","other membranes","","SMIM26","ENSG00000232388","","","",48,49.7,47.7,251.3,281.5,85.3,{"$f":"AVERAGE(S2:U2)/AVERAGE(V2:X2)","v":0.2352370166639703},{"$f":"LOG(Y2,2)","v":-2.0878129957864755},{"$f":"TTEST(V2:X2,S2:U2,2,2)","v":0.06111905704796492},{"$f":"-LOG10(AA2)","v":1.2138233547272712},{"$f":"AA2*7309/AE2","v":0.2574750362902453},{"$f":"-LOG10(AC2)","v":0.5892648719701906},1735]
["A0A0B4J2F0","Protein PIGBOS1 [OS=Homo sapiens]",19,1,1,1,54,6.3,8.5,3.82,"stress response;other biological processes","other membranes;mitochondrion","","PIGBOS1","ENSG00000225973","","","",73.7,65.2,62.7,42.3,98.1,55.7,1.0280469148393678,0.03990610330776774,0.9199872080221303,{"$f":"-LOG10(AA3)","v":0.03621821126751477},0.9465352623076788,{"$f":"-LOG10(AC3)","v":0.02386320215408641},7104]
["A0A1B0GVM6","Uncharacterized protein C11orf97 [OS=Homo sapiens]",6,1,1,1,126,13.9,9.35,2.08,"","cytoskeleton;other cell component","","C11orf97","ENSG00000257057","","","",179.3,176.3,194.6,184.6,165.2,271.8,0.8851351351351353,-0.17603036409149922,0.5138996064102778,0.28912171493578437,0.6647950837615434,0.17731220087124994,5650]
["A0AV96","RNA-binding protein 47 [OS=Homo sapiens]",22,9,24,9,593,64.1,7.68,76.54,"RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus","nucleic acid binding activity","RBM47","ENSG00000163694","","","TYROBP causal network in microglia",1517.9,1470,1495.4,2427.4,2137.3,2465,0.6377654807459777,-0.648902081499618,1.2475691914665805E-3,2.9039353586193397,0.04383886163667902,1.3581407316981282,208]
["A0AVK6","Transcription factor E2F8 [OS=Homo sapiens]",2,1,1,1,867,94.1,8.98,2.02,"cell cycle OR cell proliferation;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","E2F8","ENSG00000129173","","TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest","Genotoxicity pathway",69.1,65.5,67.6,55.7,63.9,429.8,0.36803785948307244,-1.4420739131728415,0.40127217924193337,0.3965609494626374,0.5870493110647099,0.2313254172807624,4996]
["A0AVT1-1","Ubiquitin-like modifier-activating enzyme 6 [OS=Homo sapiens]",46,38,125,37,1052,117.9,6.14,376.11,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","UBA6; UBE1L2","ENSG00000033178","Ubiquitin mediated proteolysis","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation","",12485.1,12858.3,12589.8,11917.7,11594.7,13800.7,1.0166188282399478,0.023778855510307707,0.7814961340869608,0.10707316601184884,0.8515139004236131,0.069808258061924,6708]
["A0FGR8-2","Isoform 2 of Extended synaptotagmin-2 [OS=Homo sapiens]",31,20,56,20,893,98.8,8.68,171.95,"","","","ESYT2","","","","",4261.6,4426.2,4515.4,3942.7,3944,5552,0.9824759835400746,-0.025505953522345342,0.8917169006455521,0.04977300212840964,0.9255266723684096,0.0336110609786021,7042]
["A0JLT2","Mediator of RNA polymerase II transcription subunit 19 [OS=Homo sapiens]",5,1,1,1,244,26.3,9.82,3.01,"other biological processes","nucleus","other molecular function","MED19","ENSG00000156603","","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","",115.4,117,121.2,105.2,117.4,226.6,0.7871772039180766,-0.34523965300916964,0.4558027212260908,0.34122308632995785,0.6221217720712413,0.20612459961385934,5355]
["A0JNW5-1","UHRF1-binding protein 1-like [OS=Homo sapiens]",9,10,15,10,1464,164.1,6.32,37.87,"","cytosol;other cytoplasmic organelle","other molecular function","UHRF1BP1L","ENSG00000111647","","RND2 GTPase cycle","",1031.6,966.4,1018.8,1131,1203.2,1931.1,0.7072890535249573,-0.4996281615178479,0.1797461153802065,0.7453404866873368,0.4225681432338145,0.37410324684655566,3109]
["A0MZ66","Shootin-1 [OS=Homo sapiens]",37,24,49,24,631,71.6,5.33,145.6,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SHTN1","ENSG00000187164","","Recycling pathway of L1","",5687,4986.4,5156.4,6728.1,6456.4,8164.3,0.7414842988833096,-0.43151195131469067,0.03210638523121277,1.4934085876913057,0.18758238981209766,0.7268079355007526,1251]
["A0PJW6","Transmembrane protein 223 [OS=Homo sapiens]",4,1,1,1,202,22,11.02,3.28,"developmental processes","other membranes","","TMEM223","ENSG00000168569","","","",23.3,20,19,21.1,21,122.1,0.379415347137637,-1.3981500587538032,0.37062402895369656,0.43106642715501114,0.5690947537022203,0.24481541799153128,4760]
["A0PK00","Transmembrane protein 120B [OS=Homo sapiens]",9,2,2,2,339,40.2,8.9,9.39,"cell organization and biogenesis;transport;other biological processes","other membranes;nucleus","","TMEM120B","ENSG00000188735","","","",283.6,269.5,287.7,219.3,255,285.2,1.107044107965767,0.14671270457273258,0.24346940457244762,0.6135556063598209,0.4810807996810002,0.31778197579124196,3699]
["A1A4S6","Rho GTPase-activating protein 10 [OS=Homo sapiens]",23,14,19,14,786,89.3,7.18,61.26,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","enzyme regulator activity","ARHGAP10","ENSG00000071205","Bacterial invasion of epithelial cells","Regulation of PAK-2p34 activity by PS-GAP/RHG10; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle","Ectoderm differentiation; Ectoderm differentiation",1501.7,1468.7,1615.7,1464.4,1402.6,1580.4,1.0311867608040655,0.044305646464518414,0.5369948749002269,0.2700298592039308,0.6779919745458212,0.1687754468867613,5789]
["A1L0T0","Acetolactate synthase-like protein [OS=Homo sapiens]",30,13,32,13,632,67.8,8.15,108.67,"other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","ILVBL","ENSG00000105135","","","",2247.2,2444,2410.8,2179.6,2147.2,2475.2,1.0441046750955603,0.06226635431312988,0.4542601706693356,0.34269534026401977,0.6207118316362262,0.20710997627506383,5349]
["A2AJT9-1","BCLAF1 and THRAP3 family member 3 [OS=Homo sapiens]",3,2,2,2,711,83.8,9.7,4.71,"other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","BCLAF3","ENSG00000173681","","","",109.3,107.9,111.5,210.3,232.3,338.7,0.42070907461922435,-1.2491051577719676,0.0190367202790038,1.7204078714673723,0.14754972271393293,0.8310616023207278,943]
["A2RRP1-1","neuroblastoma-amplified sequence [OS=Homo sapiens]",17,31,67,31,2371,268.4,5.96,179.73,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","NBAS","ENSG00000151779","","COPI-dependent Golgi-to-ER retrograde traffic","",5054.6,4960.8,5130.7,4878.7,4713.7,6019.2,0.9701824284506395,-0.043672044623534544,0.7264423939433593,0.13879881905962277,0.8153512680178152,0.08865524905679466,6512]
["A2RTX5","Probable threonine--tRNA ligase 2, cytoplasmic [OS=Homo sapiens]",20,13,26,11,802,92.6,6.05,55.39,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","other molecular function","TARS3","ENSG00000185418","Aminoacyl-tRNA biosynthesis","","",1101,1074.6,1091.8,1143.6,1083.2,1076.6,0.9891021371919838,-0.01580858986648407,0.6247232121596591,0.20431235714735438,0.7429388151114462,0.1290469511837408,6146]
["A2RU49","Hydroxylysine kinase [OS=Homo sapiens]",5,1,1,1,373,41.9,6.84,3.01,"other metabolic processes","mitochondrion","kinase activity","HYKK","ENSG00000188266","Lysine degradation; Metabolic pathways","Lysine catabolism","",29,28.4,33.3,35.9,27.7,126.8,0.47636554621848737,-1.0698590227794214,0.3548819223683961,0.44991612298436784,0.5625313317264383,0.24985328331980244,4611]
["A2RU67","Protein FAM234B [OS=Homo sapiens]",6,3,6,3,622,67,5.02,18.88,"","other membranes;cytoskeleton;ER/Golgi","","FAM234B","ENSG00000084444","","","",452.9,450.6,443.9,474,475.7,618.1,0.8594208444954714,-0.21856332605389633,0.19933316880820837,0.7004204291880245,0.4401589519091223,0.3563904610797703,3310]
["A2RUC4","tRNA wybutosine-synthesizing protein 5 [OS=Homo sapiens]",7,2,4,2,315,36.5,7.55,10.06,"RNA metabolism OR transcription;other metabolic processes","other cell component","nucleic acid binding activity;other molecular function","TYW5","ENSG00000162971","","Synthesis of wybutosine at G37 of tRNA(Phe)","",259.9,255.3,267.6,249.7,247.3,250.2,1.0476445396145608,0.06714930091714169,0.032623042134235045,1.4864755429735867,0.18893963150485257,0.7236769359977292,1262]
["A2RUR9","Coiled-coil domain-containing protein 144A [OS=Homo sapiens]",2,3,7,2,1427,165,5.36,13.7,"","","","CCDC144A","ENSG00000170160","","","",135,126.8,131.9,107,121.1,198.6,0.9226622920084371,-0.11612539804206998,0.7198742509507747,0.14274336035731694,0.8107181664405566,0.09113009527371321,6490]
["A2RUS2","DENN domain-containing protein 3 [OS=Homo sapiens]",9,7,10,7,1198,135.8,7.06,23.16,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol;other cell component","enzyme regulator activity","DENND3","ENSG00000105339","","RAB GEFs exchange GTP for GDP on RABs","",660.6,694.5,703.3,735.7,702.1,775.8,0.9298879653053845,-0.10487118687615521,0.10695997059379428,0.9707787251454235,0.3333775799872249,0.4770636103125526,2345]
["A3KMH1","von Willebrand factor A domain-containing protein 8 [OS=Homo sapiens]",14,19,30,19,1905,214.7,7.4,99.05,"","mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","VWA8","ENSG00000102763","","","",3106,3155.6,3074.7,2826.6,2908.5,3020.7,1.0662989104365106,0.09261191854318188,0.03377182497182393,1.4714454701973492,0.19224164230456472,0.7161525320462107,1284]
["A3KN83-1","protein strawberry notch homolog 1 [OS=Homo sapiens]",6,5,8,5,1393,154.2,7.88,19.95,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","SBNO1","ENSG00000139697","","","",117.1,120,136.8,119.2,118,125.7,1.0303113805456048,0.043080414378834586,0.6075985390496565,0.21638327905453647,0.7293377766322778,0.1370712912250861,6089]
["A4D1E9-1","GTP-binding protein 10 [OS=Homo sapiens]",26,8,19,8,387,42.9,9.03,60.89,"other biological processes","mitochondrion;nucleus;other cell component","other molecular function","GTPBP10","ENSG00000105793","","","",1707.7,1697,1698.2,1626,1598.6,2402.9,0.9067792092403376,-0.14117678174174714,0.5434740986740423,0.26482114904040127,0.6824003070277572,0.16596078644130893,5821]
["A4D1P6-1","WD repeat-containing protein 91 [OS=Homo sapiens]",18,10,19,10,747,83.3,6.58,71.16,"transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle","enzyme regulator activity","WDR91","ENSG00000105875","","CDC42 GTPase cycle","",1839,1877.5,1842.4,1910,1861.6,1666.9,1.02213845729521,0.031590634752577604,0.6223034097482956,0.20599781940631764,0.7410256796758378,0.1301667416181485,6138]
["A5A3E0","POTE ankyrin domain family member F [OS=Homo sapiens]",13,11,339,2,1075,121.4,6.2,1022.65,"","other cell component","","POTEF","ENSG00000196604","","","",468.1,623.6,579,364.9,434.4,225.5,1.6302693208430914,0.7051103176765214,0.04877544495535125,1.3117987600519003,0.23194517057817976,0.6346146656676724,1537]
["A5LHX3","proteasome subunit beta type-11 [OS=Homo sapiens]",5,1,1,1,300,32.5,6.46,2.88,"protein metabolism;other metabolic processes;developmental processes","cytosol;nucleus;other cell component","other molecular function","PSMB11","ENSG00000222028","Proteasome","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling","",36.2,40.7,36.5,33.2,26.9,108.3,0.6733966745843232,-0.570471498124167,0.5224476209918777,0.2819572440771482,0.6701596458107466,0.17382172709663327,5698]
["A5PLN9-1","Trafficking protein particle complex subunit 13 [OS=Homo sapiens]",4,2,4,2,417,46.5,5.6,9.61,"","cytosol;ER/Golgi","","C5orf44; TRAPPC13","ENSG00000113597","","RAB GEFs exchange GTP for GDP on RABs","",454.5,462.7,463.7,481.4,491.6,621,0.8663111668757841,-0.20704278093279171,0.18977924080965472,0.721751295043015,0.4315794869563679,0.3649392055863678,3214]
["A5YKK6","CCR4-NOT transcription complex subunit 1 [OS=Homo sapiens]",19,40,103,40,2376,266.8,7.11,284.22,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","CNOT1","ENSG00000125107","RNA degradation","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","Ciliary landscape",8512,8682.3,8849.1,9575.5,9325.3,14309,0.7842082758703756,-0.3506912279701851,0.21528267762028125,0.6669909135884072,0.4566166833217166,0.340448224816444,3446]
["A6NC62","Putative RBAK downstream neighbor protein [OS=Homo sapiens]",6,1,1,1,111,12.3,8.76,2.34,"","","","RBAKDN","","","","",168.1,160.7,157.2,161.9,173.2,181.8,0.9402205455600693,-0.08892888845296165,0.19349960856102144,0.7133199091978364,0.43423046944197286,0.3622797058787366,3257]
["A6NC98","Coiled-coil domain-containing protein 88B [OS=Homo sapiens]",41,50,114,50,1476,164.7,5.11,346.24,"cell organization and biogenesis;stress response;transport;other biological processes","cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","CCDC88B","ENSG00000168071","","","",8490.4,7659.4,8446.4,9566.4,9578.2,10639.8,0.8258081411745745,-0.27612145359016427,0.01796600519271281,1.7455484791308717,0.1438264314934698,0.8421612947811977,913]
["A6ND36-1","Protein FAM83G [OS=Homo sapiens]",3,2,2,2,823,90.8,6.39,5.4,"signal transduction","cytosol;nucleus","other molecular function","FAM83G","ENSG00000188522","","","",62.4,62.1,53.4,76.3,65,124.5,0.6693002257336343,-0.5792745940090146,0.1880571012466623,0.7257102624861389,0.4308806749253463,0.3656429836593471,3190]
["A6NDG6","glycerol-3-phosphate phosphatase [OS=Homo sapiens]",38,10,26,10,321,34,6.14,84.02,"protein metabolism;other metabolic processes;other biological processes","other cell component","other molecular function","PGP","ENSG00000184207","Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism","Glycolysis","",3434,3536.1,3407.9,3260.2,3459.1,3532.5,1.0123100333599955,0.017651202177202615,0.665412816320902,0.17690883856812417,0.7705168368963042,0.11321786688551513,6312]
["A6NDU8","UPF0600 protein C5orf51 [OS=Homo sapiens]",42,8,16,8,294,33.6,5.26,52.53,"","cytosol;nucleus","","C5orf51","ENSG00000205765","","","",1375.9,1314.9,1356.2,1512.7,1549.9,888.6,1.0242457987446851,0.03456197517834185,0.8892433191913542,0.05097938894704976,0.9241403981188124,0.034262044476483025,7033]
["A6NED2","RCC1 domain-containing protein 1 [OS=Homo sapiens]",7,1,2,1,376,40.1,5.27,8.95,"cell organization and biogenesis","plasma membrane;other membranes;cytosol;other cell component","","RCCD1","ENSG00000166965","","","",19.3,11.9,14.5,10.1,13.5,17.5,1.1119221411192215,0.1530557713763869,0.6410233526424747,0.19312614873543227,0.7542240316265046,0.12249963390798027,6212]
["A6NEE1","Pleckstrin homology domain-containing family D member 1 [OS=Homo sapiens]",1,1,3,1,506,59.2,6.44,6.54,"","","","PLEKHD1","ENSG00000175985","","","",496.4,481.5,489.4,566.3,547.1,640.4,0.8366404379062606,-0.2573203644682631,0.02939089875321632,1.5317871333015123,0.18143418833383285,0.7412808738044404,1184]
["A6NF36","Coiled-coil domain-containing protein 182 [OS=Homo sapiens]",5,1,1,1,153,17.5,6.58,2.1,"developmental processes","","","CCDC182","ENSG00000166329","","","",328.2,317,323.2,299.4,278.1,163,1.3077650236326805,0.3871033438227263,0.14830991054728573,0.8288298270418214,0.38548973548723736,0.41398718150563474,2812]
["A6NFI3","Zinc finger protein 316 [OS=Homo sapiens]",1,1,1,1,1004,108.4,5.31,1.81,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF316","ENSG00000205903","Herpes simplex virus 1 infection","","",97,99.1,116.8,130.7,138,329.6,0.5229817817148588,-0.9351674044140338,0.21956874539421442,0.6584294796539044,0.46115745979491757,0.33615076171651237,3480]
["A6NFQ2","TRPM8 channel-associated factor 2 [OS=Homo sapiens]",10,7,10,7,919,100.8,7.17,35.62,"other biological processes","plasma membrane;other membranes;other cell component","other molecular function","TCAF2","ENSG00000170379","","","",801.8,741.2,766.9,721.7,739.8,932.8,0.9647496136657896,-0.05177353384828648,0.7075111961524301,0.1502666831694029,0.8019850081696822,0.09583375008246421,6448]
["A6NHR9-1","structural maintenance of chromosomes flexible hinge domain-containing protein 1 [OS=Homo sapiens]",19,35,74,35,2005,226.2,7.3,199.26,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SMCHD1","ENSG00000101596","","","",9009.9,9182.3,8946.4,9475,9740.7,10286.6,0.9198808228510996,-0.1204811330862045,0.03407632327983941,1.4675472702849648,0.19292319663233634,0.714615550667412,1291]
["A6NI79","Coiled-coil domain-containing protein 69 [OS=Homo sapiens]",15,5,6,5,296,34.8,5.76,11.39,"cell cycle OR cell proliferation;cell organization and biogenesis","cytoskeleton;nucleus;other cell component","cytoskeletal activity","CCDC69","ENSG00000198624","","","",605,557.1,523.6,518.2,518.1,400.8,1.1729872660218494,0.2301873515191515,0.1439651530540835,0.8417426167086184,0.3795964298962108,0.42067788076441454,2772]
["A6NIH7","Protein unc-119 homolog B [OS=Homo sapiens]",35,5,10,5,251,28.1,5.68,36.45,"cell organization and biogenesis;transport;developmental processes","cytosol;other cell component","other molecular function","UNC119B","ENSG00000175970","","Trafficking of myristoylated proteins to the cilium","",855.3,859.2,851.6,801.2,836.9,1088.4,0.941169998166147,-0.08747276262390626,0.5860267590175909,0.23208255287550583,0.7144736583251997,0.14601377842640034,5995]
["A6NJ78","Probable methyltransferase-like protein 15 [OS=Homo sapiens]",16,4,5,4,407,46.1,8.62,15.12,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","other molecular function","METTL15","ENSG00000169519","","","",182,174.5,169.5,170.3,160.6,214.8,0.963899578522998,-0.0530452441929778,0.7201591896927352,0.14257149306391076,0.8109141145376986,0.09102514031106158,6491]
["A6NK58","Putative lipoyltransferase 2, mitochondrial [OS=Homo sapiens]",4,1,1,1,231,25.2,8.27,2.54,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","other molecular function","LIPT2","ENSG00000175536","Lipoic acid metabolism; Metabolic pathways; Biosynthesis of cofactors","Glyoxylate metabolism and glycine degradation","",63.1,68.1,70.3,78.9,84.2,198.5,0.557245575221239,-0.843614838999858,0.24373661423467607,0.6130792259828423,0.48108855345429313,0.31777497614831185,3703]
["A6NK97-2","Isoform 2 of Solute carrier family 22 member 20 [OS=Homo sapiens]",5,1,1,1,347,37,7.78,0,"","","","SLC22A20P","","","","",18.6,28.2,40.1,25,16.6,38.5,1.0848938826466918,0.11755393440569034,0.8116976388591813,0.09060571734682815,0.872712274554539,0.05912891570989607,6798]
["A6NKF1","SAC3 domain-containing protein 1 [OS=Homo sapiens]",7,2,2,2,404,43.5,8.69,6.58,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;nucleus;other cell component","","SAC3D1","","","","",170.4,172.9,186.6,223.8,183.7,237.9,0.8210412147505423,-0.2844734504436064,0.08620653609425281,1.0644598051491276,0.3014753934511454,0.5207481293762087,2090]
["A7E2V4","Zinc finger SWIM domain-containing protein 8 [OS=Homo sapiens]",6,6,7,6,1837,197.2,6.8,22.41,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","other molecular function","ZSWIM8","ENSG00000214655","","Regulation of expression of SLITs and ROBOs","",476.1,477.4,520.6,590.7,586.6,896.1,0.7109578470145654,-0.49216407049393796,0.12587431615069697,0.9000628758646255,0.3592406781512863,0.44461449244908224,2561]
["A8MVU1","Putative neutrophil cytosol factor 1C [OS=Homo sapiens]",33,8,20,8,366,41.8,8.84,66.73,"other metabolic processes","other cell component","enzyme regulator activity;other molecular function","NCF1C","","","","",1314.7,1314.7,1428.8,1575.4,1490.5,2348.5,0.7495197990543736,-0.4159615064803549,0.17627364045600818,0.7538126262168283,0.41830650587433893,0.37850538083329954,3080]
["A8MW92","PHD finger protein 20-like protein 1 [OS=Homo sapiens]",1,1,1,1,1017,114.9,6.83,2.6,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","PHF20L1","ENSG00000129292","","","",45.7,44,59.5,77.4,78,64.2,0.6794171220400728,-0.5576305187499611,0.024383079727383263,1.612911441287894,0.16486209965536008,0.7828791733572315,1081]
["A8MXV4","nucleoside diphosphate-linked moiety X motif 19 [OS=Homo sapiens]",12,2,13,2,375,42.2,7.64,35.47,"other metabolic processes","cytosol;other cytoplasmic organelle","other molecular function","NUDT19","ENSG00000213965","Peroxisome","Peroxisomal lipid metabolism; Peroxisomal protein import","",1029.5,1120.5,1135.7,968.4,908.5,307.5,1.5041659036806445,0.5889636994738239,0.16083057282406468,0.7936313912423257,0.39929030460974485,0.398711235023814,2944]
["A9UHW6","MIF4G domain-containing protein [OS=Homo sapiens]",18,4,6,4,222,25.4,5.33,20.28,"other biological processes","cytosol;ER/Golgi;nucleus","nucleic acid binding activity;other molecular function","MIF4GD","ENSG00000125457","","","",469,490.7,454.2,574.4,609.8,916,0.6732215979430531,-0.5708466336896229,0.10371966268908486,0.9841389042870607,0.32860295387712235,0.48332853692418126,2307]
["B2RTY4","unconventional myosin-IXa [OS=Homo sapiens]",1,3,4,3,2548,292.5,8.88,9.32,"cell organization and biogenesis;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","MYO9A","ENSG00000066933","","RHOA GTPase cycle; RHOB GTPase cycle; RHOV GTPase cycle","",196.6,213.2,229.6,203.7,199,631.4,0.6183154433807175,-0.6935850553079054,0.41161571367011685,0.3855080541478006,0.5931583697190229,0.22682933713750386,5072]
["B5ME19","eukaryotic translation initiation factor 3 subunit C-like protein [OS=Homo sapiens]",44,41,177,1,914,105.4,5.64,520.95,"cell organization and biogenesis;protein metabolism;other metabolic processes","translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3CL","ENSG00000205609","","","",600.3,573.7,567.6,681.2,692.4,1038.4,0.7220563847429519,-0.46981659459924063,0.1303834045751431,0.8847776828379914,0.3649836476597935,0.43772659277696285,2611]
["B7ZC32","Kinesin-like protein KIF28P [OS=Homo sapiens]",1,1,1,1,967,108.2,8.43,1.83,"cell organization and biogenesis;transport;other biological processes","other membranes;cytoskeleton;mitochondrion","cytoskeletal activity;other molecular function","KIF28P","","","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",89.5,84.4,88.2,74.7,69.1,108,1.0409054805401112,0.057839070609400994,0.7929613741023978,0.10074796706164459,0.8599042556846328,0.06554990171299145,6740]
["B9A064-1","Immunoglobulin lambda-like polypeptide 5 [OS=Homo sapiens]",48,8,196,8,214,23,8.84,691.91,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","IGLL5","ENSG00000254709","","","",30251.1,33072.5,30366,42363.8,37975.4,53210.2,0.7015351622695422,-0.5114126786251229,0.04521699454277087,1.3446983074676089,0.22270283902500831,0.652274246526644,1484]
["C9J798","Ras GTPase-activating protein 4B [OS=Homo sapiens]",17,12,17,12,803,90.4,7.74,47.22,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol","enzyme regulator activity;other molecular function","RASA4B","ENSG00000170667","","","Ras signaling",1851.5,1878.5,1939,1996.9,2038.5,2414.6,0.8789147286821706,-0.18620489137855237,0.12675075197879002,0.8970494554323365,0.3607559369988225,0.4427865129451791,2568]
["C9JI98","Transmembrane protein 238 [OS=Homo sapiens]",6,1,1,1,176,18,11.53,2.83,"","other membranes","","TMEM238","ENSG00000233493","","","",167.9,207.3,143.4,141.9,164.1,152,1.1323144104803495,0.17927460786898858,0.36287974119315536,0.4402372768631329,0.5649175779298771,0.24801491158128963,4695]
["C9JRZ8","Aldo-keto reductase family 1 member B15 [OS=Homo sapiens]",5,2,7,1,316,36.5,6.7,14.99,"other metabolic processes","cytosol;mitochondrion","other molecular function","AKR1B15","ENSG00000227471","","Estrogen biosynthesis","",531.6,422,628.1,428.9,324.6,145.3,1.759790832220739,0.8154039611063375,0.0894334411756899,1.048500058358061,0.30631163146818996,0.5138365115625393,2134]
["L0R6Q1","SLC35A4 upstream open reading frame protein [OS=Homo sapiens]",47,5,18,5,103,11.1,8.1,62.31,"stress response","other membranes","","SLC35A4","ENSG00000176087","","","",2545,2443.5,2556.9,1898.8,2251.4,1431.4,1.3518345993980219,0.43491864479635545,0.05269910177972294,1.278196786977857,0.24013574495510906,0.6195431890420288,1604]
["O00115","Deoxyribonuclease-2-alpha [OS=Homo sapiens]",10,4,11,4,360,39.6,8.05,21.95,"cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes","other cytoplasmic organelle","nucleic acid binding activity;other molecular function","DNASE2","ENSG00000105612","Lysosome","Lysosome Vesicle Biogenesis","",1365.7,1287.3,1300.6,1199.4,1293.7,1838.2,0.9127975434627017,-0.13163318586259387,0.5642184443380577,0.2485527208334154,0.6978968708185587,0.15620874892910894,5909]
["O00116","Alkyldihydroxyacetonephosphate synthase, peroxisomal [OS=Homo sapiens]",36,17,47,17,658,72.9,7.34,166.8,"other metabolic processes","cytosol;nucleus;other cytoplasmic organelle","other molecular function","AGPS","ENSG00000018510","Ether lipid metabolism; Metabolic pathways; Peroxisome","Plasmalogen biosynthesis; TYSND1 cleaves peroxisomal proteins","Triacylglyceride synthesis",4360.1,4566.9,4740.2,4356.3,4094.6,5517,0.9784720680989986,-0.03139742726494394,0.8348974498012542,0.07836686549909677,0.8879897352440872,0.05159205443830969,6872]
["O00124-1","UBX domain-containing protein 8 [OS=Homo sapiens]",8,1,1,1,270,30.5,7.78,3.78,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","UBXN8","ENSG00000104691; ENSPTRG00000049759","Protein processing in endoplasmic reticulum","","",14.1,15,12.5,20.3,12.5,31.2,0.65,-0.6214883767462701,0.2441223462452639,0.6123924647171047,0.481070431034412,0.31779133616174193,3709]
["O00139","Kinesin-like protein KIF2A [OS=Homo sapiens]",38,19,40,1,706,79.9,6.68,110.76,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KIF2A","ENSG00000068796","","COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Kinesins; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",3662.2,3600.8,3760.6,3818.6,3718.5,4630,0.9060170459682257,-0.1423899012356262,0.26224328372236777,0.5812956256498124,0.49772426920976004,0.3030111823885706,3851]
["O00139-2","Isoform 2 of Kinesin-like protein KIF2A [OS=Homo sapiens]",39,19,42,1,660,75,6.4,112.68,"","","","KIF2A","","","","",187.7,162.1,177.9,167.5,193,471.5,{"$f":"AVERAGE(S66:U66)/AVERAGE(V66:X66)","v":0.6342548076923077},{"$f":"LOG(Y66,2)","v":-0.6568655448353373},{"$f":"TTEST(V66:X66,S66:U66,2,2)","v":0.3575754488382693},0.4466323075497704,{"$f":"AA66*7309/AE66","v":0.5641094227409692},0.24863664586895268,4633]
["O00142","thymidine kinase 2, mitochondrial [OS=Homo sapiens]",15,3,5,3,265,31,8.46,13.08,"DNA metabolism;other metabolic processes","mitochondrion;other cell component","kinase activity;other molecular function","TK2","ENSG00000166548","Pyrimidine metabolism; Drug metabolism; Metabolic pathways","Pyrimidine salvage","Pyrimidine metabolism",522,545.2,549.1,454.1,439.1,490.1,1.1684377936817756,0.22458092869863583,0.010989862100754234,{"$f":"-LOG10(AA67)","v":1.9590077570084687},0.11491402302491086,{"$f":"-LOG10(AC67)","v":0.9396269708701771},699]
["O00148","ATP-dependent RNA helicase DDX39A [OS=Homo sapiens]",56,22,194,9,427,49.1,5.68,472.72,"RNA metabolism OR transcription;other metabolic processes;transport","nucleus;other cell component","other molecular function","DDX39A","ENSG00000123136","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","",23828.5,24337.5,25097.6,25702.3,23819.2,21174.1,1.036324750055166,0.051476166999190505,0.5643646511437901,0.24844019600550382,0.6979595998663217,0.15616971500278626,5910]
["O00151","PDZ and LIM domain protein 1 [OS=Homo sapiens]",73,16,96,16,329,36,7.02,326.94,"cell organization and biogenesis;stress response;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","PDLIM1","ENSG00000107438","","","",11707.4,11594.5,11191.7,12502.6,13141.8,10253.8,0.9608726899955989,-0.057582799870683134,0.626534419318979,0.2030550655960871,0.7442450952059837,0.12828401880014284,6153]
["O00154","cytosolic acyl coenzyme A thioester hydrolase [OS=Homo sapiens]",39,14,70,14,380,41.8,8.54,221.44,"other metabolic processes","cytosol;mitochondrion;nucleus","other molecular function","ACOT7","ENSG00000097021","Fatty acid elongation; Biosynthesis of unsaturated fatty acids","Mitochondrial Fatty Acid Beta-Oxidation","",6503.6,6510.9,6610.4,5621.5,5603.7,6431.7,1.1114578436758433,0.15245322963059746,0.0757150666481138,1.1208176910275762,0.2827804916356994,0.5485505548016044,1957]
["O00159-1","Unconventional myosin-Ic [OS=Homo sapiens]",24,25,63,25,1063,121.6,9.41,176.7,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","MYO1C","ENSG00000197879","Pathogenic Escherichia coli infection","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Translocation of SLC2A4 (GLUT4) to the plasma membrane","VEGFA-VEGFR2 signaling pathway; Insulin signaling",9210.7,8925.4,9137.6,8970.4,8543.7,8856.5,1.0342464714492654,0.048580035521968844,0.12157044911089217,0.915171978909855,0.3524626785210277,0.452886862702328,2521]
["O00161","Synaptosomal-associated protein 23 [OS=Homo sapiens]",57,11,42,11,211,23.3,5.01,126.62,"cell-cell signaling;cell organization and biogenesis;stress response;transport","plasma membrane;other membranes;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","SNAP23","ENSG00000092531","SNARE interactions in vesicular transport; Platelet activation","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; ER-Phagosome pathway; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; trans-Golgi Network Vesicle Budding","Insulin signaling",4426.9,4556,4463.7,3792.4,4336.9,4031.3,1.1057513609525846,0.14502701789863867,0.05739799159694927,1.2411033036581651,0.250910239582597,0.6004816148771899,1672]
["O00165","HCLS1-associated protein X-1 [OS=Homo sapiens]",45,10,25,10,279,31.6,4.92,86.17,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","HAX1","ENSG00000143575","","","",2580.3,2628.3,2635.1,2995.9,3300.3,4735.6,0.7110081763628783,-0.4920619444233305,0.1187880751196836,0.9252271550590331,0.34798478599189075,0.4584397431344689,2495]
["O00170","AH receptor-interacting protein [OS=Homo sapiens]",27,7,27,7,330,37.6,6.29,89.27,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","AIP","ENSG00000110711","Cushing syndrome; Chemical carcinogenesis","Aryl hydrocarbon receptor signalling; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","Aryl hydrocarbon receptor Netpath; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway",2795.1,2495.4,2509.8,3532,3435.6,3761.4,0.7270295460900363,-0.45991409919997206,0.002069217902579281,2.6841937727925513,0.05420757580627945,1.265940014182176,279]
["O00178","GTP-binding protein 1 [OS=Homo sapiens]",34,16,39,16,669,72.4,8.34,131.59,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;other cytoplasmic organelle","nucleic acid binding activity;other molecular function","GTPBP1","ENSG00000100226","","","",3320.1,3342.3,3298.1,3173.6,3308.3,3119.7,1.0373791868021998,0.05294332995330799,0.10603145549732165,0.9745652769770212,0.3320410917865998,0.4788081668023997,2334]
["O00186","syntaxin-binding protein 3 [OS=Homo sapiens]",19,9,24,9,592,67.7,7.8,66.92,"cell adhesion;cell-cell signaling;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","STXBP3","ENSG00000116266","","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Disinhibition of SNARE formation","Insulin signaling",2360.6,2234.7,2292.2,2164.9,2140.5,2261.8,1.048772688512608,0.06870202139269196,0.1089314340510239,0.9628467789677672,0.33608267263779384,0.47355387780655933,2369]
["O00189","AP-4 complex subunit mu-1 [OS=Homo sapiens]",7,3,3,3,453,49.9,7.2,9.07,"transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","AP4M1","ENSG00000221838","Lysosome","Lysosome Vesicle Biogenesis","",225.6,224.7,220.6,210,207.8,360.2,0.8623393316195374,-0.2136724115214669,0.5183100973351685,0.28541033047316305,0.6677822142469146,0.17536515215389228,5673]
["O00193","Small acidic protein [OS=Homo sapiens]",33,6,29,6,183,20.3,4.72,110.48,"","","","SMAP","ENSG00000110696","","","",2790.5,2735.8,2985.6,3074.4,3436.3,3777.8,0.8273217670214316,-0.2734795546051809,0.052340197981559984,1.2811646389346476,0.23984608592302314,0.6200673644438746,1595]
["O00203-1","AP-3 complex subunit beta-1 [OS=Homo sapiens]",36,36,116,35,1094,121.2,6.04,322.39,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","AP3B1","ENSG00000132842","Lysosome","Golgi Associated Vesicle Biogenesis; Signaling by BRAF and RAF1 fusions","",16489.2,16932,17394.5,15594.9,15066.6,11748.1,1.198212197238361,0.2608834246495064,0.08530689093954466,1.0690158858765129,0.2996194453998712,0.5234300042041669,2081]
["O00214-1","Galectin-8 [OS=Homo sapiens]",10,3,6,3,317,35.8,8.25,21.56,"other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;cytosol;other cell component","signal transduction activity or receptor binding;other molecular function","LGALS8","ENSG00000116977","","","",373.6,401.7,432.5,443.3,400.6,1220.6,0.5850326955679341,-0.7734108404210436,0.3451449042224677,0.46199853422526327,0.5555305230041877,0.2552920742422569,4541]
["O00217","NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [OS=Homo sapiens]",31,6,19,6,210,23.7,6.34,49.75,"cell organization and biogenesis;other metabolic processes;stress response;transport","other membranes;mitochondrion","transporter activity;other molecular function","NDUFS8","ENSG00000110717","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",2015.8,1849.2,1784.5,2671.5,2675.8,2494.1,0.7204708342897953,-0.4729880657047421,1.3206652744282988E-3,2.8792072413478453,0.04407644972966409,1.3557933943039908,219]
["O00221","NF-kappa-B inhibitor epsilon [OS=Homo sapiens]",22,7,15,7,500,52.8,6.68,46.7,"other biological processes","cytosol;nucleus;other cell component","","NFKBIE","ENSG00000146232","Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; Neurotrophin signaling pathway; Adipocytokine signaling pathway; Epstein-Barr virus infection; PD-L1 expression and PD-1 checkpoint pathway in cancer","Activation of NF-kappaB in B cells","TNF-alpha signaling pathway; Apoptosis; Oxidative damage response; Canonical NF-kB pathway; IL-18 signaling pathway; STING pathway in Kawasaki-like disease and COVID-19",1309.3,1249.8,1322,1579.3,1686.8,5556.6,0.4398993505389507,-1.18475462361188,0.2765157888391966,0.5582800657698792,0.5094665743951823,0.29288430436005675,3967]
["O00231","26S proteasome non-ATPase regulatory subunit 11 [OS=Homo sapiens]",69,27,96,26,422,47.4,6.48,321.34,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","PSMD11","ENSG00000108671","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection","Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling pathway",15040.6,15779.2,15013.5,17054.6,15760.9,19822.4,0.8707281255521212,-0.19970577003129422,0.13746968924571715,0.8617930490661994,0.37324144082353145,0.4280101427341656,2692]
["O00232-1","26s proteasome non-atpase regulatory subunit 12 [OS=Homo sapiens]",61,28,163,28,456,52.9,7.65,457.29,"protein metabolism;other metabolic processes","non-structural extracellular;cytosol;nucleus;other cell component","","PSMD12","ENSCANG00000030312; ENSCATG00000032968; ENSCSAG00000004164; ENSG00000197170; ENSMFAG00000032701; ENSMLEG00000034943; ENSMMUG00000002132; ENSMNEG00000032475; ENSNLEG00000001265; ENSPANG00000020562; ENSPPYG00000008565; ENSRROG00000042400","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection","Activation of NF-kappaB in B cells; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease",15418.8,15236.3,16372.7,15355.9,13956.8,11641,1.1483162693480689,0.19952004391247663,0.15012645802503388,0.8235427617095917,0.38786648345880975,0.41131774728260945,2829]
["O00233-1","26S proteasome non-ATPase regulatory subunit 9 [OS=Homo sapiens]",30,6,24,6,223,24.7,6.95,72.5,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PSMD9","ENSG00000110801","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease",2341.3,2190.7,2130.9,2237.1,2323,2075.8,1.0040687774077368,0.005858095410800136,0.9296341752112488,0.03168791912667139,0.9531064927225442,0.02085857195568814,7129]
["O00244","Copper transport protein ATOX1 [OS=Homo sapiens]",40,3,9,3,68,7.4,7.24,33.66,"stress response;transport;other biological processes","cytosol","other molecular function","ATOX1","ENSG00000177556","Mineral absorption","Detoxification of Reactive Oxygen Species; Ion influx/efflux at host-pathogen interface","Copper homeostasis",1134.5,1162.6,1113.1,1138.8,1217.3,991.6,1.0186695343071364,0.026686103966178393,0.7736046459742548,0.11148093071031445,0.8458154610958607,0.07272438042434463,6685]
["O00255-1","Menin [OS=Homo sapiens]",23,10,17,10,615,68,6.55,59.91,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","MEN1","ENSG00000133895","Cushing syndrome; Transcriptional misregulation in cancer","RHO GTPases activate IQGAPs; Formation of the beta-catenin:TCF transactivating complex; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",1361.3,1336.4,1417.9,1427.1,1456.8,1922,0.8563640525187792,-0.2237038577129368,0.22864901599685636,0.6408306632885694,0.46983290917093706,0.3280565665903768,3557]
["O00257-1","E3 SUMO-protein ligase CBX4 [OS=Homo sapiens]",5,2,3,2,560,61.3,9.36,8.25,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","CBX4","ENSG00000141582; ENSPTRG00000040905","","SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Oxidative Stress Induced Senescence; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN gene transcription","",207.5,210.4,221.7,201.9,223.2,266,0.9254811170597596,-0.11172454034219706,0.4248749658671511,0.3717388572984597,0.6011248791178877,0.22103529725178508,5166]
["O00258-1","Tail-anchored protein insertion receptor WRB [OS=Homo sapiens]",12,2,3,2,174,19.8,9.67,7.23,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;ER/Golgi;nucleus","","GET1; WRB","ENSANAG00000014374; ENSCANG00000035340; ENSCATG00000041953; ENSCCAG00000026562; ENSCSAG00000008355; ENSG00000182093; ENSMLEG00000038301; ENSMNEG00000036276; ENSNLEG00000033928; ENSPANG00000032093; ENSPPAG00000034665; ENSPPYG00000011427; ENSPTRG00000013915; ENSSBOG00000020756","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",370.2,355.2,379.4,346.9,358.3,271.4,1.1312717591644479,0.17794554162058704,0.20378250152898836,0.6908331108873482,0.44461083691802267,0.3520199560402205,3350]
["O00264","Membrane-associated progesterone receptor component 1 [OS=Homo sapiens]",61,12,49,10,195,21.7,4.7,143.13,"other metabolic processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","PGRMC1","ENSG00000101856","","Neutrophil degranulation","",3642.2,3245.1,3073.6,3056.2,3665.6,2840.3,1.0417063197414793,0.05894860701090821,0.6796363548025732,0.16772339809631168,0.7809247158075786,0.10739083178887113,6361]
["O00267","Transcription elongation factor Spt5 [OS=Homo sapiens]",35,32,126,32,1087,120.9,5.06,422.29,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","SUPT5H","ENSG00000196235","","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE","Initiation of transcription and translation elongation at the HIV-1 LTR; mRNA processing",11161.4,11018.7,11434.9,10375.5,10216.4,9399.7,1.120813827871804,0.1645466600239596,0.020744712246347326,1.683092584970474,0.1533095063787185,0.8144309146836805,989]
["O00268","Transcription initiation factor TFIID subunit 4 [OS=Homo sapiens]",8,6,7,6,1085,110,9.94,21.59,"RNA metabolism OR transcription;other metabolic processes;developmental processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","TAF4","ENSG00000130699","Basal transcription factors; Huntington disease","RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation","",620.7,617.8,642.2,777.7,756.3,749.8,0.8234959278395655,-0.2801665789978939,2.9784280725513338E-4,3.526012883418498,0.02502221928997437,1.6016741741531433,87]
["O00273-1","DNA fragmentation factor subunit alpha [OS=Homo sapiens]",50,11,30,3,331,36.5,4.79,101.46,"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","DFFA","ENSG00000160049","Apoptosis","Apoptosis induced DNA fragmentation","Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis",2957.4,2994.1,3109.8,3664.1,3806.5,5204,0.7149180250264306,-0.48415026791649884,0.07113662723547998,1.1479067296442436,0.2737954757578321,0.5625737324972881,1899]
["O00273-2","Isoform DFF35 of DNA fragmentation factor subunit alpha [OS=Homo sapiens]",55,9,25,1,268,29.4,4.61,92.3,"","","","DFFA","","","","",67.9,69.4,74.7,90.3,72.7,135,0.7114093959731544,-0.49124806589896225,0.1992276262244057,0.7006504395823934,0.44032498339104365,0.35622667261212326,3307]
["O00287","Regulatory factor X-associated protein [OS=Homo sapiens]",7,1,1,1,272,28.2,5.54,2.31,"other biological processes","nucleus","nucleic acid binding activity","RFXAP","ENSG00000133111","Antigen processing and presentation; Tuberculosis; Primary immunodeficiency","","",14.9,16.4,18.8,12.7,11.1,3.2,1.8555555555555558,0.8918511961443778,0.07078186815263457,1.1500779791713251,0.2735825882218964,0.5629115461323918,1891]
["O00291","Huntingtin-interacting protein 1 [OS=Homo sapiens]",4,3,3,2,1037,116.1,5.3,7.67,"cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","HIP1","ENSG00000127946","Huntington disease; Pathways of neurodegeneration","Clathrin-mediated endocytosis; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants","",81.6,91.8,91.6,94.5,91.5,141.6,0.8089133089133088,-0.30594299730308494,0.27636801269421407,0.558512224374176,0.5097082525314183,0.29267833482439265,3963]
["O00299","chloride intracellular channel protein 1 [OS=Homo sapiens]",86,18,273,17,241,26.9,5.17,1010.2,"other metabolic processes;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;mitochondrion;nucleus;other cell component","transporter activity","CLIC1","ENSG00000206394; ENSG00000213719; ENSG00000223639; ENSG00000226248; ENSG00000226417; ENSG00000226651; ENSG00000230685","","","VEGFA-VEGFR2 signaling pathway",30139.4,31087.6,29075.4,29428.6,30336.2,19887.3,1.1337102223293547,0.18105193284428045,0.3543720273380324,0.450540566841971,0.5624549723808205,0.24991223949086586,4605]
["O00300","Tumor necrosis factor receptor superfamily member 11B [OS=Homo sapiens]",2,1,1,1,401,46,8.29,2.56,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","TNFRSF11B","ENSG00000164761","Cytokine-cytokine receptor interaction; Osteoclast differentiation","TNFs bind their physiological receptors","Osteoclast signaling; RANKL/RANK signaling pathway; Ectoderm differentiation; Vitamin D receptor pathway; Osteoblast signaling; IL-18 signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta; Overlap between signal transduction pathways contributing to LMNA laminopathies; Monoamine transport",172.3,124.4,189.5,149.9,131.5,138,1.1592751549833098,0.21322303193213663,0.3323626036559057,0.4783878475219296,0.5478660961030706,0.26132557441642595,4434]
["O00303","Eukaryotic translation initiation factor 3 subunit F [OS=Homo sapiens]",47,12,71,12,357,37.5,5.45,236.86,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3F","ENSG00000175390","","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","Translation factors; VEGFA-VEGFR2 signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell",7029.7,7301.3,7281.8,7458,7639.6,7674.9,0.9490745416620925,-0.07540669187393559,0.024787561238670444,1.6057661998432702,0.16621310559031402,0.7793347358999209,1090]
["O00308","NEDD4-like E3 ubiquitin-protein ligase WWP2 [OS=Homo sapiens]",9,6,6,6,870,98.9,7.12,10.1,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","WWP2","ENSG00000198373","Ubiquitin mediated proteolysis","RHOQ GTPase cycle; Regulation of PTEN stability and activity; RHOJ GTPase cycle; NOTCH3 Activation and Transmission of Signal to the Nucleus; RHOU GTPase cycle","",547.3,569.9,626,781,766,837.9,0.7309321145540693,-0.4521906730380439,0.002618236922481063,2.5819910569943487,0.05834357825126247,1.2340069388220545,328]
["O00327-1","Isoform BMAL1A of Aryl hydrocarbon receptor nuclear translocator-like protein 1 [OS=Homo sapiens]",2,1,1,1,583,64.2,6.98,2.86,"","","","ARNTL","","","","",33.7,29.2,37.1,40.7,36.4,23.8,0.9910802775024777,-0.012926174444270145,0.95957993604344,0.01791884131770841,0.9727558602692793,0.011996144153164459,7210]
["O00330-1","Pyruvate dehydrogenase protein X component, mitochondrial [OS=Homo sapiens]",29,14,42,14,501,54.1,8.66,119.68,"other metabolic processes","mitochondrion;other cell component","other molecular function","PDHX","ENSG00000110435","Metabolic pathways","Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid","Amino acid metabolism",6313.9,6224.9,6359.5,6065,5880.9,8357.9,0.9307765048907101,-0.10349330088826413,0.5885620536230989,0.2302077416134713,0.7161311886018361,0.1450074116768536,6007]
["O00391","Sulfhydryl oxidase 1 [OS=Homo sapiens]",2,1,1,1,747,82.5,8.92,2.8,"cell organization and biogenesis;other biological processes","non-structural extracellular;other membranes;ER/Golgi;other cell component","other molecular function","QSOX1","ENSG00000116260","","Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",34.9,34.6,32.7,30.1,23.5,11.5,1.5698924731182797,0.650665747771986,0.08730231982015402,1.058974215954153,0.30327597697980313,0.5181619895518815,2104]
["O00399","Dynactin subunit 6 [OS=Homo sapiens]",22,4,9,4,190,20.7,6.32,21.9,"cell cycle OR cell proliferation;cell organization and biogenesis","cytosol;cytoskeleton;other cell component","other molecular function","DCTN6","ENSG00000104671","Vasopressin-regulated water reabsorption; Amyotrophic lateral sclerosis; Huntington disease; Pathways of neurodegeneration; Salmonella infection","MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic","",1141.7,1142.3,1148.4,1212.3,1218,2029.8,0.7695791574179952,-0.37785836789073973,0.2756945546286621,0.5595718117617594,0.5098814523737073,0.292530785793377,3952]
["O00400","Acetyl-coenzyme A transporter 1 [OS=Homo sapiens]",23,12,40,12,549,60.9,7.33,119.98,"transport;signal transduction","plasma membrane;other membranes;ER/Golgi","transporter activity","SLC33A1","ENSG00000169359","Glycosphingolipid biosynthesis; Metabolic pathways","Transport of vitamins, nucleosides, and related molecules; Defective SLC33A1 causes spastic paraplegia 42 (SPG42)","Ganglio sphingolipid metabolism",4105.5,4726.8,4730,4236.2,3712.8,4514.2,1.0881876243661337,0.1219273262625313,0.3074973137500961,0.5121586738027303,0.5351185395712982,0.27155000231665777,4200]
["O00401","Neural Wiskott-Aldrich syndrome protein [OS=Homo sapiens]",2,1,1,1,505,54.8,7.93,1.92,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity","WASL","ENSG00000106299","Endocytosis; Adherens junction; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection","Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RHOJ GTPase cycle; RHOV GTPase cycle; NOSTRIN mediated eNOS trafficking; Nephrin family interactions; EPHB-mediated forward signaling; DCC mediated attractive signaling","Pathogenic Escherichia coli infection; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Chemokine signaling pathway; G13 signaling pathway",153.9,146,142.8,144.1,145.7,92,1.1595075955997907,0.21351227069392836,0.321186788402064,0.4932423271607477,0.5416599530296922,0.26627327226057385,4334]
["O00410","Importin-5 [OS=Homo sapiens]",59,46,321,43,1097,123.6,4.94,1059.57,"transport;other biological processes","nucleus;other cell component","enzyme regulator activity;other molecular function","IPO5","ENSG00000065150","Nucleocytoplasmic transport","vRNP Assembly","",32556.9,33689.3,32688.2,32169.4,31506.5,24107.6,1.1270272887273807,0.1725224479280893,0.22729857604862752,0.6434032849796515,0.4693009300393838,0.3285485851214663,3540]
["O00411","DNA-directed RNA polymerase, mitochondrial [OS=Homo sapiens]",19,16,52,16,1230,138.5,8.98,169.38,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","POLRMT","ENSG00000099821","","Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis","Mitochondrial gene expression",2934.8,2837.1,2784.5,3221.2,3059.9,4222.6,0.8146081856869484,-0.2958217833810061,0.15110672839638034,0.8207161972072213,0.38875011539920584,0.4103294690461842,2841]
["O00418","Eukaryotic elongation factor 2 kinase [OS=Homo sapiens]",16,11,19,11,725,82.1,5.33,36.59,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;other cell component","nucleic acid binding activity;kinase activity;other molecular function","EEF2K","ENSG00000103319","AMPK signaling pathway; Oxytocin signaling pathway","mTORC1-mediated signalling","Translation factors; AMP-activated protein kinase (AMPK) signaling; BDNF-TrkB signaling",1594.3,1606.7,1621.2,1695.3,1608.5,2592.4,0.8178487839625519,-0.29009397396274766,0.31866883832505166,0.49666040281163915,0.5409081605475622,0.2668764664151345,4306]
["O00422","Histone deacetylase complex subunit SAP18 [OS=Homo sapiens]",52,8,41,8,153,17.6,9.35,77,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","SAP18","ENSG00000150459","Nucleocytoplasmic transport; mRNA surveillance pathway","Potential therapeutics for SARS; HDACs deacetylate histones; NoRC negatively regulates rRNA expression","Hedgehog signaling pathway Netpath",4511.6,4506.7,4335.6,4930.1,5002.2,4738.1,0.910261478896281,-0.13564706592746478,0.010921719433094917,1.9617089842025763,0.11485877314602987,0.9398358269087174,695]
["O00425","Insulin-like growth factor 2 mRNA-binding protein 3 [OS=Homo sapiens]",2,2,2,2,579,63.7,8.87,2.02,"protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","IGF2BP3","ENSG00000136231","","Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA","",140.1,150.7,152.2,160.9,155.1,86.3,1.101168282376336,0.13903496081675049,0.6058312065982764,0.21764835975131747,0.7284126154016782,0.1376225412517856,6079]
["O00429","Dynamin-1-like protein [OS=Homo sapiens]",70,45,189,1,736,81.8,6.81,589.96,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","DNM1L","ENSG00000087470","Necroptosis; NOD-like receptor signaling pathway; TNF signaling pathway","Apoptotic execution phase","Synaptic vesicle pathway; CAMKK2 pathway",19192.6,19309.3,19575,18290.6,17781.6,15240.3,1.1318275274056027,0.17865413103712244,0.07657386362781599,1.1159194394946952,0.28482359758560155,0.5454240323221676,1965]
["O00429-2","Isoform 4 of Dynamin-1-like protein [OS=Homo sapiens]",71,45,192,1,725,80.5,6.71,609.4,"","","","DNM1L","","","","",386.2,390.4,372.5,402.7,419.6,447.6,0.9048743995590203,-0.14421054104360603,0.04673488840604979,1.330358789984953,0.2269669763188159,0.6440373280308421,1505]
["O00442","RNA 3'-terminal phosphate cyclase [OS=Homo sapiens]",44,14,51,14,366,39.3,7.85,155.6,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","RTCA","ENSG00000137996","","","",4345.3,4352.5,4566.9,4173.4,3915.1,3798.1,1.1159372739050695,0.15825593651354816,0.02570310010233361,1.5900144923830972,0.169399421684361,0.7710880766482844,1109]
["O00443","phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [OS=Homo sapiens]",16,23,31,23,1686,190.6,8.02,87.31,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","PIK3C2A","ENSG00000011405","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Salmonella infection","Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane","Glioblastoma signaling pathways; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; Osteoblast differentiation and related diseases; Insulin signaling; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)",2359.7,2382.5,2360.8,2998.7,3003.3,3676.6,0.7338871324365093,-0.44636989284735257,0.01893722540903662,1.7226836514053565,0.14724700054749856,0.8319535431210822,940]
["O00459","Phosphatidylinositol 3-kinase regulatory subunit beta [OS=Homo sapiens]",6,3,5,3,728,81.5,6.43,10.37,"other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;cytosol;nucleus","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","PIK3R2","ENSG00000105647","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; Platinum drug resistance; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Phosphatidylinositol signaling system; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Osteoclast differentiation; Focal adhesion; Signaling pathways regulating pluripotency of stem cells; Platelet activation; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; TNF signaling pathway; Leukocyte transendothelial migration; Neurotrophin signaling pathway; Cholinergic synapse; Inflammatory mediator regulation of TRP channels; Regulation of actin cytoskeleton; Insulin signaling pathway; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Prolactin signaling pathway; Thyroid hormone signaling pathway; Regulation of lipolysis in adipocytes; Relaxin signaling pathway; GnRH secretion; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Aldosterone-regulated sodium reabsorption; Carbohydrate digestion and absorption; Alzheimer disease; Spinocerebellar ataxia; Prion disease; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection; Chagas disease; Amoebiasis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","Downstream TCR signaling; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOJ GTPase cycle; Nephrin family interactions; Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; RND2 GTPase cycle; RHOA GTPase cycle; G alpha (q) signalling events; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; Extra-nuclear estrogen signaling; RHOU GTPase cycle; PIP3 activates AKT signaling; Synthesis of PIPs at the plasma membrane; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Interleukin receptor SHC signaling; Regulation of signaling by CBL; RAF/MAP kinase cascade; PI3K Cascade; GPVI-mediated activation cascade; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; Costimulation by the CD28 family; CD28 dependent PI3K/Akt signaling; VEGFA-VEGFR2 Pathway; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; RND3 GTPase cycle; RND1 GTPase cycle","IL-5 signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase (AMPK) signaling; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL-6 signaling pathway; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Ebola virus pathway in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Modulators of TCR signaling and T cell activation; Orexin receptor pathway; Regulation of actin cytoskeleton; Alzheimer's disease; G13 signaling pathway; Interferon type I signaling pathways; Notch signaling pathway (Netpath); ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway",225.7,235.3,252.9,288,282.3,380.6,0.7507624355873384,-0.4135716281863921,0.07390363624504935,1.1313341926970713,0.27872119572500814,0.5548300035278448,1938]
["O00461","Golgi integral membrane protein 4 [OS=Homo sapiens]",38,23,53,23,696,81.8,4.77,156.08,"","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","GOLIM4","ENSG00000173905","","Intra-Golgi traffic","",3703.8,3729.8,3947.4,4137.1,4307.5,3796.1,0.9297670884835016,-0.1050587360577942,0.16522992509282758,0.7819112940270023,0.40539292464030774,0.39212383535807305,2979]
["O00462","Beta-mannosidase [OS=Homo sapiens]",14,11,21,10,879,100.8,5.52,57.12,"protein metabolism;other metabolic processes","plasma membrane;other membranes;other cytoplasmic organelle","other molecular function","MANBA","ENSG00000109323","Other glycan degradation; Lysosome","Neutrophil degranulation; Lysosomal oligosaccharide catabolism","",1391.2,1414.2,1500.2,1318.6,1323.4,1890.2,0.9500022064339615,-0.07399723069889506,0.7149488016795393,0.14572505742155192,0.8075352791648513,0.09283849535978644,6471]
["O00463","TNF receptor-associated factor 5 [OS=Homo sapiens]",2,1,3,1,557,64.4,7.43,5.82,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton","signal transduction activity or receptor binding;other molecular function","TRAF5","ENSG00000082512","NF-kappa B signaling pathway; Necroptosis; NOD-like receptor signaling pathway; IL-17 signaling pathway; TNF signaling pathway; Shigellosis; Human cytomegalovirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Viral carcinogenesis; Small cell lung cancer","","RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Small cell lung cancer; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling",25.7,29.3,35.7,38.9,36.8,20,0.9477533960292582,-0.07741637395750292,0.8146512374059904,0.08902827848412186,0.8746013358108672,0.05818986367668038,6808]
["O00469-1","procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 [OS=Homo sapiens]",4,2,2,2,737,84.6,6.71,7.23,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","other molecular function","PLOD2","ENSG00000152952","Lysine degradation; Metabolic pathways","Collagen biosynthesis and modifying enzymes","Clear cell renal cell carcinoma pathways; Type I collagen synthesis in the context of osteogenesis imperfecta",177.3,160.1,165.7,213.1,233.8,283.6,0.6887063655030801,-0.5380390834053582,0.024420429699203754,1.612246698525812,0.16496203389231076,0.7826159974123896,1082]
["O00470","Homeobox protein Meis1 [OS=Homo sapiens]",2,1,1,1,390,43,6.33,2.92,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MEIS1","ENSG00000143995","Signaling pathways regulating pluripotency of stem cells; Transcriptional misregulation in cancer","Activation of anterior HOX genes in hindbrain development during early embryogenesis","Mesodermal commitment pathway",33.7,28.2,23.7,53,61.9,52.2,0.5122681029323758,-0.9650290316600411,0.003062894472253998,2.513867965944741,0.06377975982251986,1.195317120526592,351]
["O00471","Exocyst complex component 5 [OS=Homo sapiens]",21,14,26,14,708,81.8,6.71,63.68,"cell organization and biogenesis;transport;other biological processes","cytosol;other cell component","other molecular function","EXOC5","ENSG00000070367","Salmonella infection","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium","Ciliary landscape",2087.6,2104.6,2217.5,2119.4,2100,3453.2,0.8354012981257983,-0.25945870958848016,0.40223437803586004,0.3955208140146867,0.5882215024137857,0.230459103921145,4998]
["O00479","High mobility group nucleosome-binding domain-containing protein 4 [OS=Homo sapiens]",27,3,5,3,90,9.5,10.48,8.92,"cell organization and biogenesis","nucleus;other cell component","nucleic acid binding activity;other molecular function","HMGN4","ENSG00000182952","","","",783.3,820.6,885,575.9,683.9,539,1.3836446519902157,0.4684734771968478,0.011979239083720849,1.9215707672752884,0.11863991661641692,0.925769167214357,738]
["O00481-1","Butyrophilin subfamily 3 member A1 [OS=Homo sapiens]",10,5,6,2,513,57.6,8.03,14.04,"cell cycle OR cell proliferation;signal transduction;other biological processes","plasma membrane;other membranes","signal transduction activity or receptor binding","BTN3A1","ENSG00000026950","","Butyrophilin (BTN) family interactions","",240.2,236,251.8,230.2,211.3,212.8,1.1126394620204798,0.1539861797241518,0.0330514462478153,1.4808095321328503,0.19006531913869554,0.7210971208028853,1271]
["O00483","Cytochrome c oxidase subunit NDUFA4 [OS=Homo sapiens]",56,5,23,5,81,9.4,9.38,59.42,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","NDUFA4","ENSG00000189043","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; Oxidative phosphorylation",4629.2,4148.4,4188.1,4209.6,5351,2755.8,1.0527183267838003,0.07411946968478443,0.7917027858815411,0.1014378268414527,0.8591767872320984,0.06591746501648421,6735]
["O00487","26S proteasome non-ATPase regulatory subunit 14 [OS=Homo sapiens]",47,12,47,12,310,34.6,6.52,121.33,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PSMD14","ENSG00000115233","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection","Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; Metalloprotease DUBs","Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease",5524.4,5662.5,6039.6,5230.7,5249.7,4488.4,1.1508270536048315,0.20267104141643288,0.06275325862674333,1.2023637173868684,0.2585476704074786,0.587459370998603,1774]
["O00499","Myc box-dependent-interacting protein 1 [OS=Homo sapiens]",4,2,6,1,593,64.7,5.06,19.85,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","BIN1","ENSG00000136717","Endocytosis; Fc gamma R-mediated phagocytosis","Clathrin-mediated endocytosis","VEGFA-VEGFR2 signaling pathway; IL-18 signaling pathway",54,47.1,43.8,58.4,55.3,50.5,0.8824604141291108,-0.18039653222087554,0.1642415302945349,0.7845170171483264,0.4040529602567336,0.3935617070680176,2971]
["O00505","Importin subunit alpha-4 [OS=Homo sapiens]",28,11,49,7,521,57.8,4.94,140.19,"cell organization and biogenesis;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","KPNA3","ENSG00000102753","Nucleocytoplasmic transport; Salmonella infection; Chemical carcinogenesis","ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways","",1001.6,1036.2,1035.9,1016,1092.6,662.2,1.1093186083441606,0.1496737826888743,0.49020493558486816,0.3096223204064983,0.6483727604397035,0.18817523910301787,5526]
["O00506","serine/threonine-protein kinase 25 [OS=Homo sapiens]",23,7,35,2,426,48.1,6.74,85.36,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","kinase activity;other molecular function","STK25","ENSG00000115694","","","",73,65.8,68.6,65.7,75,246.5,0.5356404958677686,-0.9006630584613688,0.3658175721052873,0.4367354369539995,0.5669551811954082,0.24645127149307802,4716]
["O00507-1","Probable ubiquitin carboxyl-terminal hydrolase FAF-Y [OS=Homo sapiens]",9,21,47,1,2555,290.9,5.86,131.75,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","USP9Y","ENSG00000114374","","","",107.5,156.4,149.1,115,132.6,181.1,{"$f":"AVERAGE(S130:U130)/AVERAGE(V130:X130)","v":0.9633776533706554},{"$f":"LOG(Y130,2)","v":-0.05382663551016505},{"$f":"TTEST(V130:X130,S130:U130,2,2)","v":0.8441192747463928},0.0735961828716205,{"$f":"AA130*7309/AE130","v":0.8937661566161648},0.04877609437595335,6903]
["O00512","B-cell CLL/lymphoma 9 protein [OS=Homo sapiens]",1,1,1,1,1426,149.2,8.91,0,"cell-cell signaling;developmental processes;signal transduction;other biological processes","ER/Golgi;nucleus","other molecular function","BCL9","ENSG00000116128","","Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex","Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; 1q21.1 copy number variation syndrome",15,17.6,21.5,15.7,17.8,45,0.6891719745222931,-0.537064059952174,0.4456083364001833,{"$f":"-LOG10(AA131)","v":0.35104669301670455},0.6138242236616924,{"$f":"-LOG10(AC131)","v":0.21195597677904193},5306]
["O00519","Fatty-acid amide hydrolase 1 [OS=Homo sapiens]",25,10,26,10,579,63,7.66,84.13,"other metabolic processes","other membranes;cytoskeleton;ER/Golgi","other molecular function","FAAH","ENSG00000117480","Retrograde endocannabinoid signaling","Arachidonic acid metabolism","Cannabinoid receptor signaling",2296.5,2306.8,2294.9,2007.5,2099.8,2778.6,1.0017862588768354,2.5747279420257466E-3,0.9873538756949598,0.0055271647395791,0.9906066544206535,0.004098758961615095,7285]
["O00522","Krev interaction trapped protein 1 [OS=Homo sapiens]",9,6,11,6,736,84.3,8.41,34.25,"developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","KRIT1","ENSG00000001631","Rap1 signaling pathway","","",961,928.3,1008.1,899.8,920,1279.5,0.9348562578646791,-0.09718353952120355,0.6201984450513032,0.20746932695145803,0.7399657908716902,0.130788357538039,6126]
["O00534","von Willebrand factor A domain-containing protein 5A [OS=Homo sapiens]",5,4,4,4,786,86.4,6.58,7.8,"","nucleus","","VWA5A","ENSG00000110002","","","",424.1,438.1,479,451.6,417.8,420.5,1.0397705248468874,0.05626516375566536,0.43478569755631447,0.3617247506357284,0.6078516953785582,0.21620236766026216,5228]
["O00541-1","Pescadillo homolog [OS=Homo sapiens]",32,18,54,18,588,68,7.33,167.5,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PES1","ENSG00000100029","","Major pathway of rRNA processing in the nucleolus and cytosol","",6523,6540.1,6542.4,8828.2,8283.3,8207.2,0.7743486039962557,-0.3689448954003903,0.000623853824884087,3.2049171578864932,0.03280393961207045,1.4840739962566152,139]
["O00555-1","Voltage-dependent P/Q-type calcium channel subunit alpha-1A [OS=Homo sapiens]",1,1,2,1,2505,282.2,8.84,2.07,"","","","","","","","",869.8,624.4,845.3,536.3,571.9,221.5,1.7594194179138154,0.8150994396128105,0.06853318681329293,1.1640990728922374,0.2691612371941741,0.5699874841390314,1861]
["O00559","Receptor-binding cancer antigen expressed on SiSo cells [OS=Homo sapiens]",8,1,1,1,213,24.4,6.29,3.29,"other biological processes","other membranes;ER/Golgi;other cell component","enzyme regulator activity","EBAG9","ENSG00000147654","Estrogen signaling pathway","Estrogen-dependent gene expression","",34.1,45.6,44.7,42.6,51.4,74.3,0.7391562685680333,-0.43604869119934647,0.22260685546776712,0.6524614651316929,0.46407116560579287,0.33341541500549615,3506]
["O00560-1","Syntenin-1 [OS=Homo sapiens]",23,4,13,4,298,32.4,7.53,47.62,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","SDCBP","ENSG00000137575; ENSPPAG00000038846; ENSPTRG00000020277","","Neutrophil degranulation; Ephrin signaling; Neurofascin interactions; Regulation of necroptotic cell death","Ectoderm differentiation; Ectoderm differentiation; VEGFA-VEGFR2 signaling pathway",900.6,986.4,992,813.2,835.5,1467.3,0.923940949935815,-0.11412744449823493,0.7335977393238127,0.1345420156705139,0.8201079652367309,0.08612897003089115,6538]
["O00566","U3 small nucleolar ribonucleoprotein protein Mpp10 [OS=Homo sapiens]",27,15,32,15,681,78.8,4.86,83.9,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","MPHOSPH10","ENSG00000124383","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",2232.5,2023.4,2192.4,3835.5,3701,2119.3,0.6678162348018807,-0.5824769287348144,0.12619853114559693,0.8989456999181474,0.3597445647984274,0.4440057588809543,2564]
["O00567","Nucleolar protein 56 [OS=Homo sapiens]",67,29,161,29,594,66,9.19,489.84,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NOP56","ENSG00000101361","Ribosome biogenesis in eukaryotes; Spinocerebellar ataxia","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; Association of TriC/CCT with target proteins during biosynthesis","",17465.7,17993.1,17911.9,17149.4,16242.9,16429.3,1.0712361706569038,0.0992765796904125,0.021178585138613946,1.674103056835581,0.15371825102098244,0.813274565505226,1007]
["O00571","ATP-dependent RNA helicase DDX3X [OS=Homo sapiens]",58,34,224,33,662,73.2,7.18,686.69,"cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function","DDX3X","ENSG00000215301","RIG-I-like receptor signaling pathway; Hepatitis B; Viral carcinogenesis","Neutrophil degranulation","Novel intracellular components of RIG-I-like receptor (RLR) pathway; Hepatitis B infection",27691.5,27657.4,27479.5,33554.5,33132.1,22239.6,0.9314285328733263,-0.10248301731969219,0.6123468698012458,0.21300249784498068,0.732871012179025,0.13497245595687332,6107]
["O00592","Podocalyxin [OS=Homo sapiens]",13,7,19,7,558,58.6,5.49,54.88,"cell adhesion;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","","PODXL","ENSG00000128567","Salmonella infection","","Primary focal segmental glomerulosclerosis (FSGS); Ectoderm differentiation; Hepatitis C and hepatocellular carcinoma; Nephrotic syndrome; Malignant pleural mesothelioma",2967.8,3001.3,3136,2436.9,2684,2327.5,1.2224236077546857,0.28974431044779597,0.009254872245599151,2.0336295718775026,0.10652576573714048,0.9725453352855055,635]
["O00625","Pirin [OS=Homo sapiens]",10,3,9,3,290,32.1,6.92,14.48,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PIR","ENSG00000087842","","Digestion","",1059.3,1095.8,1114.7,1135.8,1048.9,1355.1,0.9237245042092775,-0.1144654550152634,0.38586867437866973,0.4135604769266432,0.5784073299905039,0.23776621198901457,4876]
["O00629","Importin subunit alpha-3 [OS=Homo sapiens]",41,13,91,9,521,57.9,4.96,346.45,"transport","other membranes;cytosol;nucleus","other molecular function","KPNA4","ENSG00000186432","Nucleocytoplasmic transport; Salmonella infection; Chemical carcinogenesis","ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways","Leptin signaling pathway",10076.2,10591.1,10699.8,9700.6,10471,6426,1.1793206905886247,0.2379560811770328,0.2739226630384675,0.5623720348311766,0.508405470834982,0.29378978474930306,3938]
["O00635","E3 ubiquitin-protein ligase TRIM38 [OS=Homo sapiens]",8,4,9,4,465,53.4,7.02,15.62,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","TRIM38","ENSG00000112343","","Interferon gamma signaling","",793.7,706.6,756.7,762.7,771.6,2036.2,0.6321243523316062,-0.6617196997051941,0.3598953684166117,0.4438237423552884,0.564722036873554,0.2481652646699773,4658]
["O00743","Serine/threonine-protein phosphatase 6 catalytic subunit [OS=Homo sapiens]",33,9,31,9,305,35.1,5.69,93.67,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport","cytosol;mitochondrion;nucleus","other molecular function","PPP6C","ENSG00000119414","","Telomere Extension By Telomerase; COPII-mediated vesicle transport","",3768,3832.3,3943.9,3754.2,3731.2,3826,1.0205810067719292,0.02939069822552891,0.2572839664887522,0.5895872774601764,0.4938257644606853,0.3064262552886401,3808]
["O00746","Nucleoside diphosphate kinase, mitochondrial [OS=Homo sapiens]",16,2,4,2,187,20.6,10.29,10.56,"other metabolic processes;transport","other membranes;mitochondrion","kinase activity;other molecular function","NME4","ENSG00000103202","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors","Interconversion of nucleotide di- and triphosphates","Pyrimidine metabolism",425.8,441.9,451.9,361.1,418.5,419,1.1009511096278992,0.13875040399450064,0.12272691831561491,0.9110601708200672,0.35426976539053295,0.4506659102814117,2532]
["O00750","Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [OS=Homo sapiens]",2,3,3,3,1634,184.7,7.3,8.8,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","PIK3C2B","ENSG00000133056","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Salmonella infection","Synthesis of PIPs at the plasma membrane","Glioblastoma signaling pathways; S1P receptor signal transduction; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; EGF/EGFR signaling pathway; Osteoblast differentiation and related diseases; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)",173.5,191.4,158.3,200.9,207.5,222.7,0.8290286800823959,-0.2705060825548423,0.03563605361418719,1.448110396343298,0.19510405682853496,0.709733700159919,1335]
["O00754","Lysosomal alpha-mannosidase [OS=Homo sapiens]",11,10,16,10,1011,113.7,7.28,49.54,"protein metabolism;other metabolic processes","non-structural extracellular;other membranes;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MAN2B1","ENSG00000104774","Other glycan degradation; Lysosome","Neutrophil degranulation; Lysosomal oligosaccharide catabolism","",1989.7,2080.1,2067.5,1786.6,1800,4479.4,0.7608851971237293,-0.3942492995481531,0.5126437980558577,0.29018429233552945,0.6642285977646275,0.1776824301769502,5641]
["O00762","Ubiquitin-conjugating enzyme E2 C [OS=Homo sapiens]",6,1,1,1,179,19.6,7.37,0,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","UBE2C","ENSG00000175063","Ubiquitin mediated proteolysis","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Gastric cancer network 1; Gastric cancer network 2",24.1,17,17.2,49.4,62.7,137.8,0.2332933173269308,-2.0997831128862074,0.08180682950881275,1.0872104384535979,0.29324478512992275,0.5327697023477649,2039]
["O00763","Acetyl-CoA carboxylase 2 [OS=Homo sapiens]",5,9,16,5,2458,276.4,6.49,54.84,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus","other molecular function","ACACB","ENSG00000076555","Fatty acid biosynthesis; Pyruvate metabolism; Propanoate metabolism; Metabolic pathways; AMPK signaling pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Glucagon signaling pathway; Insulin resistance; Alcoholic liver disease","ChREBP activates metabolic gene expression; Biotin transport and metabolism; Carnitine metabolism; Activation of gene expression by SREBF (SREBP)","AMP-activated protein kinase (AMPK) signaling; Leptin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; IL-18 signaling pathway; 7q11.23 copy number variation syndrome",504.1,483,543.4,550.4,556.6,808,0.7992167101827676,-0.3233413472853279,0.21331487783891068,0.6709788532331333,0.4548186820666856,0.34216170460032097,3428]
["O00764-1","Pyridoxal kinase [OS=Homo sapiens]",57,17,137,17,312,35.1,6.13,367.38,"other metabolic processes","non-structural extracellular;nucleus;other cell component","kinase activity;other molecular function","HEL-S-1a; PDXK","ENSG00000160209","Vitamin B6 metabolism; Metabolic pathways; Biosynthesis of cofactors","Neutrophil degranulation; Vitamins B6 activation to pyridoxal phosphate","",11817.5,11582.3,12073,10624.9,10519.4,8501,1.196574161840157,0.2589098156840345,0.05118301258817013,1.2908741554962426,0.2372204432510688,0.6248478869411725,1577]
["O00767","acyl-CoA desaturase [OS=Homo sapiens]",13,5,23,5,359,41.5,9,75.05,"other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","SCD","ENSG00000099194","Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; AMPK signaling pathway; Alcoholic liver disease","Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis","Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Adipogenesis; Liver X receptor pathway; Nuclear receptors meta-pathway; Fatty acid biosynthesis; Angiopoietin-like protein 8 regulatory pathway; PPAR signaling pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways",3633.3,3451.1,3204.5,4986.8,6148,2671.5,0.7452322490457256,-0.4242379883323712,0.3182809544898801,0.49718934820720545,0.5405008123528191,0.26720364898156523,4304]
["O14492","SH2B adapter protein 2 [OS=Homo sapiens]",13,4,8,4,632,67.7,6.27,21.53,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;other molecular function","SH2B2","ENSG00000160999","Neurotrophin signaling pathway; Insulin signaling pathway","Regulation of KIT signaling; Factors involved in megakaryocyte development and platelet production","Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; Insulin signaling",79.3,103,101.4,120.6,118,143.7,0.7420873659429769,-0.4303390495602895,0.042499614977426645,1.3716150043952517,0.2146715175328344,0.6682255736303163,1447]
["O14494","Phospholipid phosphatase 1 [OS=Homo sapiens]",4,1,2,1,284,32.1,7.97,6.94,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","PLPP1","ENSG00000067113","Glycerolipid metabolism; Glycerophospholipid metabolism; Ether lipid metabolism; Sphingolipid metabolism; Metabolic pathways; Phospholipase D signaling pathway; Fc gamma R-mediated phagocytosis; Fat digestion and absorption; Choline metabolism in cancer","Sphingolipid de novo biosynthesis","Androgen receptor signaling pathway; Androgen receptor signaling pathway; Sphingolipid pathway; Triacylglyceride synthesis; Androgen receptor signaling pathway",346.5,337.2,327.3,358.4,327.4,393,0.9371523915461625,-0.0936444294452264,0.3161251856271175,0.5001409026319306,0.5390944894420442,0.26833510745376754,4286]
["O14497","AT-rich interactive domain-containing protein 1A [OS=Homo sapiens]",21,40,81,38,2285,241.9,6.7,259.41,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ARID1A","ENSG00000117713","Thermogenesis; Hepatocellular carcinoma","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines","Pathways affected in adenoid cystic carcinoma; Tumor suppressor activity of SMARCB1; Thermogenesis",7240,7070.7,7240.4,8249.5,8664.5,9550.9,0.8143276566319918,-0.2963186941492486,0.01345525289781005,1.8711081350543546,0.12673253019341965,0.89711189442857,776]
["O14523","Phospholipid transfer protein C2CD2L [OS=Homo sapiens]",21,11,23,11,706,76.1,7.69,62.31,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","transporter activity;other molecular function","C2CD2L","ENSG00000172375","","","",1249.5,1198.7,1204.7,958.5,1110.6,1685.9,0.9728095872170438,-0.03977064801136436,0.885628423120729,0.05274845377521621,0.9211695096896837,0.03566044542846209,7027]
["O14524-1","Nuclear envelope integral membrane protein 1 [OS=Homo sapiens]",8,4,9,4,444,50.6,6.93,22.32,"cell organization and biogenesis","other membranes;nucleus","","NEMP1","ENSG00000166881","","","",1345.8,1355.8,1389.4,1438.4,1364.9,1897.1,0.8703514594502596,-0.2003299968964939,0.2907829753340962,0.5364310239990264,0.5225799770634151,0.281847234519641,4067]
["O14526-1","F-BAR domain only protein 1 [OS=Homo sapiens]",4,4,4,4,889,96.8,6.96,10.43,"cell organization and biogenesis;transport","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","FCHO1","ENSG00000130475","","Cargo recognition for clathrin-mediated endocytosis","",143.9,152,145.5,185.4,176.8,409.7,0.5718357300168415,-0.8063273281753423,0.22217381138039252,0.653307134608854,0.46382987357306166,0.33364128348991373,3501]
["O14530","Thioredoxin domain-containing protein 9 [OS=Homo sapiens]",33,6,14,6,226,26.5,5.88,40.52,"","cytosol;cytoskeleton;nucleus;other cell component","","TXNDC9","ENSG00000115514","","","",1218.9,1104.1,1055.5,1868.3,1816.3,1616,0.6373806738859752,-0.6497728192789094,2.1359317194258186E-3,2.6704126347664046,0.054019117430046046,1.2674525156389795,289]
["O14531","dihydropyrimidinase-related protein 4 [OS=Homo sapiens]",11,2,16,2,572,61.8,7.09,35.54,"cell organization and biogenesis;developmental processes;other biological processes","cytosol","cytoskeletal activity;other molecular function","DPYSL4","ENSG00000151640","","CRMPs in Sema3A signaling","",851.4,786.1,890.5,791.6,747,1400.1,0.8602443257222582,-0.21718162408826477,0.5551271008310378,0.25560757026483244,0.6920388845256789,0.1598695025656568,5863]
["O14545","TRAF-type zinc finger domain-containing protein 1 [OS=Homo sapiens]",2,1,1,1,582,64.8,5.29,1.98,"other biological processes","","other molecular function","TRAFD1","ENSG00000135148","","","Regulation of toll-like receptor signaling pathway",100.2,80.6,90.4,121.2,127,28.6,0.9797687861271679,-0.02948676450038036,0.956787445040826,0.01918453212788823,0.971137263686071,0.012719381164816575,7201]
["O14548","Cytochrome c oxidase subunit 7A-related protein, mitochondrial [OS=Homo sapiens]",11,1,1,1,114,12.6,9.42,3.72,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion;nucleus","transporter activity","COX7A2L","ENSG00000115944","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease",100.3,83.6,71.9,131,132,109,0.6876344086021505,-0.5402863571137568,0.02546797160864093,1.5940056429536902,0.16830506734860445,0.7739028080383967,1106]
["O14561","Acyl carrier protein, mitochondrial [OS=Homo sapiens]",13,2,3,2,156,17.4,4.93,8.5,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;nucleus","other molecular function","NDUFAB1","ENSG00000004779","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Glyoxylate metabolism and glycine degradation; Mitochondrial Fatty Acid Beta-Oxidation; Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",229.8,251.8,212,237.4,356.7,597,0.5823188649147848,-0.780118737529451,0.19400772553956924,0.7121809757790459,0.4345701703857529,0.3619400876829479,3263]
["O14562","Ubiquitin domain-containing protein UBFD1 [OS=Homo sapiens]",19,4,13,4,309,33.4,5.77,35.8,"","","","UBFD1","ENSG00000103353","","","",1484.4,1291.3,1250.1,1890.3,1816.8,1556.1,0.7648958808329533,-0.3866647162704256,0.02956082453711519,1.5292834563758217,0.1818687428802819,0.7402419351370235,1188]
["O14576-1","cytoplasmic dynein 1 intermediate chain 1 [OS=Homo sapiens]",6,3,4,3,645,72.9,5.12,8.9,"transport;other biological processes","cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","DNCI1; DYNC1I1","ENSG00000158560; ENSGGOG00000000228; ENSPTRG00000019422","Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection","Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Intraflagellar transport proteins binding to dynein",174,205.9,210.8,227.8,215.2,327.7,0.7664460879719734,-0.38374377899926343,0.1840111169364243,0.735155938521439,0.42791513003128384,0.36864235765504605,3143]
["O14578-4","Isoform 4 of Citron Rho-interacting kinase [OS=Homo sapiens]",5,9,11,9,2069,236.5,6.67,18.9,"","","","CIT","","","","",682.6,636.3,678.8,653.9,668.8,616.2,1.0303264737737894,0.043101548539218645,0.414913254920807,0.38204269087116277,0.5946276431796428,0.2257549050851262,5100]
["O14579-1","coatomer subunit epsilon [OS=Homo sapiens]",36,11,48,11,308,34.5,5.12,138.59,"transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","COPE","ENSG00000105669; ENSPTRG00000010723","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport","",5831.8,5816,6150,5904.8,5629.1,4351.1,1.1204154863078373,0.164033829497132,0.2637495156404856,0.578808329248213,0.4992865086289327,0.3016501689882892,3861]
["O14593","DNA-binding protein RFXANK [OS=Homo sapiens]",4,1,1,1,260,28.1,4.55,0,"signal transduction;other biological processes","non-structural extracellular;cytosol;nucleus","nucleic acid binding activity;other molecular function","RFXANK","ENSG00000064490","Antigen processing and presentation; Tuberculosis; Primary immunodeficiency","","",67.4,71.4,62.3,97.1,92.3,180.7,0.543366657660092,-0.8800020539948685,0.122307834709226,0.9125457223422747,0.35333911616194974,0.4518082816341197,2530]
["O14617-5","Isoform 5 of AP-3 complex subunit delta-1 [OS=Homo sapiens]",36,40,125,40,1215,136.6,7.64,411.02,"","","","AP3D1","","","","",12483.8,12430.1,12647,12059.2,12303.9,11535.3,1.0463112562119763,0.06531208771828656,0.07858550298980518,1.104657562767445,0.2887790052048698,0.5394343840079078,1989]
["O14618","copper chaperone for superoxide dismutase [OS=Homo sapiens]",16,5,19,5,274,29,5.58,36.89,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","CCS","ENSG00000173992","Amyotrophic lateral sclerosis; Pathways of neurodegeneration","Detoxification of Reactive Oxygen Species","Amyotrophic lateral sclerosis (ALS); Copper homeostasis",1868.6,1805.9,1814.2,1892.3,1917,3252.6,0.7772270918591314,-0.36359190496563587,0.3084535052453867,0.5108102900979742,0.5348722822867217,0.27174990717476233,4215]
["O14628-1","Zinc finger protein 195 [OS=Homo sapiens]",7,3,4,1,629,72.3,8.09,5.49,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF195","ENSG00000005801","Herpes simplex virus 1 infection","Generic Transcription Pathway","",24.3,18,37.2,25.6,36.6,9.4,1.1103351955307261,0.15099527290746112,0.7997108909321772,0.09706698946536799,0.8638910585018155,0.06354102103335676,6766]
["O14639-1","Actin-binding LIM protein 1 [OS=Homo sapiens]",7,5,6,5,778,87.6,8.59,12.99,"cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ABLIM1","ENSG00000099204","Axon guidance","DCC mediated attractive signaling","Male infertility",747.3,715.1,731.7,767.6,728.4,1006,0.8769384492406077,-0.18945250887822837,0.3046383240568807,0.5162154625250407,0.5319162710300385,0.27415672464373536,4186]
["O14641","Segment polarity protein dishevelled homolog DVL-2 [OS=Homo sapiens]",6,4,6,2,736,78.9,6.02,11.66,"cell-cell signaling;cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","DVL2","ENSG00000004975","mTOR signaling pathway; Wnt signaling pathway; Notch signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer","RHO GTPases Activate Formins; Asymmetric localization of PCP proteins; Degradation of DVL; Cargo recognition for clathrin-mediated endocytosis; WNT mediated activation of DVL; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Negative regulation of TCF-dependent signaling by DVL-interacting proteins; WNT5:FZD7-mediated leishmania damping; Signaling by Hippo; WNT5A-dependent internalization of FZD4","Alzheimer's disease and miRNA effects; Neural crest differentiation; Notch signaling; Wnt signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Type 2 papillary renal cell carcinoma; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Malignant pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)",163.9,173.2,161.2,252.2,264.8,468.8,0.5054777845404748,-0.9842804069876981,0.08186075996581392,1.0869242278384723,0.2928635803182251,0.533334632586947,2043]
["O14646","Chromodomain-helicase-DNA-binding protein 1 [OS=Homo sapiens]",13,18,26,15,1710,196.6,7.14,58.47,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CHD1","ENSG00000153922","","Estrogen-dependent gene expression","",2015.6,2091.7,2109.9,2481.4,2504.8,2489.5,0.831654560776917,-0.26594368544024904,1.4556071510089545E-4,3.836955819507827,0.020459678205239324,1.6891012012586535,52]
["O14647","Chromodomain-helicase-DNA-binding protein 2 [OS=Homo sapiens]",11,17,26,14,1828,211.2,8.1,66.08,"cell organization and biogenesis;stress response;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","CHD2","ENSG00000173575","","","Prion disease pathway; Male infertility",1395.3,1340.4,1414.7,1564.8,1646.3,1463,0.8879570398579403,-0.17143821547770813,0.038557869804447795,1.4138869674488874,0.2031863521274037,0.6921054666381993,1387]
["O14653-1","Golgi SNAP receptor complex member 2 [OS=Homo sapiens]",21,4,7,4,212,24.8,8.06,14.57,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","other molecular function","GOSR2","ENSG00000108433","SNARE interactions in vesicular transport","COPI-mediated anterograde transport; Intra-Golgi traffic; COPII-mediated vesicle transport; XBP1(S) activates chaperone genes; Cargo concentration in the ER","",555.4,625.9,588.1,641.8,730.6,596,0.8989026620605569,-0.15376319334724622,0.2099195040988351,0.6779472082542902,0.4504702452901896,0.3463338899968995,3406]
["O14656","Torsin-1A [OS=Homo sapiens]",20,6,14,6,332,37.8,6.99,37.88,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","TOR1A","ENSG00000136827","","Cargo recognition for clathrin-mediated endocytosis","",1345.4,1342.5,1336.9,1348,1279,1088.1,1.0833624936071709,0.11551605017341784,0.2550573473214213,0.593362161428265,0.49161765600534507,0.3083725282103207,3792]
["O14662-2","Isoform A of Syntaxin-16 [OS=Homo sapiens]",24,7,16,7,304,34.8,6.2,46.86,"","","","STX16","","","","",935.9,1034.1,997.4,834.2,976.3,1727.1,0.838817277250113,-0.25357151773235587,0.5323927884112327,0.27376783594420584,0.6752141055869686,0.17055849364158898,5763]
["O14672","Disintegrin and metalloproteinase domain-containing protein 10 [OS=Homo sapiens]",38,25,56,25,748,84.1,7.77,170.99,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ADAM10","ENSG00000137845","Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection","Amyloid fiber formation; Collagen degradation; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; NOTCH3 Activation and Transmission of Signal to the Nucleus; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant; Signaling by EGFR; EPH-ephrin mediated repulsion of cells; NOTCH4 Activation and Transmission of Signal to the Nucleus","Alzheimer's disease and miRNA effects; Copper homeostasis; Canonical and non-canonical Notch signaling; VEGFA-VEGFR2 signaling pathway; 3q29 copy number variation syndrome; Interactions of natural killer cells in pancreatic cancer; Alzheimer's disease; Hypertrophy model",3968.1,3931,4232.4,4325.1,4485.8,5928.8,0.8230493157934015,-0.28094921768030495,0.16899328369329578,0.7721305552259832,0.4098115164281018,0.38741584132062323,3014]
["O14681","Etoposide-induced protein 2.4 homolog [OS=Homo sapiens]",2,1,3,1,340,38.9,9.72,5.03,"other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus","other molecular function","EI24","ENSG00000149547","p53 signaling pathway","","miRNA regulation of p53 pathway in prostate cancer; Genotoxicity pathway",429.6,468,419.4,380.7,391.1,705.4,0.8915515840779855,-0.1656098220617366,0.6456236405944543,0.19002057557262358,0.7573203641638366,0.12072036494341222,6231]
["O14683","Tumor protein p53-inducible protein 11 [OS=Homo sapiens]",8,1,2,1,189,21,9.55,8.88,"other biological processes","other membranes","","TP53I11","ENSG00000175274","","","",121.1,145.5,155.5,133.4,139.1,273.4,0.7732185381938085,-0.3710518677887285,0.42836603973402065,0.36818496674012086,0.603959757796288,0.21899199771868486,5184]
["O14686-1","Histone-lysine N-methyltransferase 2D [OS=Homo sapiens]",4,13,15,12,5537,593,5.58,42.08,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","KMT2D","ENSG00000167548","Lysine degradation; Metabolic pathways; Cushing syndrome","Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","Histone modifications; 16p11.2 proximal deletion syndrome",576.3,574.7,607.2,707.1,728.6,1326.8,0.6364524886877828,-0.6518752742295157,0.1750616405548728,0.7568090059462728,0.41719123926167767,0.3796648200447853,3067]
["O14717-1","tRNA (cytosine(38)-C(5))-methyltransferase [OS=Homo sapiens]",2,1,2,1,391,44.6,6.09,5.15,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DNMT2; TRDMT1","ENSG00000107614","","tRNA modification in the nucleus and cytosol","",400.7,351.9,390.7,326.9,433.1,151.6,1.2541684949539271,0.3267311842680272,0.4068939958058231,0.3905187186196521,0.5910151461336965,0.22840138917289166,5032]
["O14730","serine/threonine-protein kinase RIO3 [OS=Homo sapiens]",12,6,7,6,519,59.1,5.76,17.24,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;other cell component","kinase activity;other molecular function","RIOK3","ENSG00000101782","","Major pathway of rRNA processing in the nucleolus and cytosol","",721,689.1,671.7,776.7,803.3,958,0.8202521670606777,-0.2858605946184455,0.05963019058837107,1.2245338025719936,0.25577292430188037,0.5921454311187019,1704]
["O14732-1","inositol monophosphatase 2 [OS=Homo sapiens]",7,2,2,2,288,31.3,6.61,5.48,"other metabolic processes;signal transduction","cytosol;other cell component","other molecular function","IMPA2","ENSG00000141401","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of IP2, IP, and Ins in the cytosol","",157.4,148.3,147.1,166.1,172.4,249.5,0.7700680272108845,-0.37694219689184416,0.17051576647550393,0.7682354584501434,0.4119999131138705,0.38510287555465805,3025]
["O14733","dual specificity mitogen-activated protein kinase kinase 7 [OS=Homo sapiens]",18,6,10,6,419,47.5,9.16,26.35,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","MAP2K7","ENSG00000076984","MAPK signaling pathway; ErbB signaling pathway; Protein processing in endoplasmic reticulum; Osteoclast differentiation; Tight junction; Toll-like receptor signaling pathway; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; TNF signaling pathway; Neurotrophin signaling pathway; GnRH signaling pathway; Relaxin signaling pathway; Alcoholic liver disease; Alzheimer disease; Huntington disease; Pathways of neurodegeneration; Salmonella infection; Yersinia infection; Hepatitis B; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Chemical carcinogenesis; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; Uptake and function of anthrax toxins","Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; MAPK signaling pathway; ERK pathway in Huntington's disease; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; MAPK cascade; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; IL-18 signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Malignant pleural mesothelioma; Alzheimer's disease; ErbB signaling pathway; Toll-like receptor signaling pathway",1197.9,1179.8,1205.6,1208.7,1302.9,933.7,1.0400545670913997,0.05665922221923225,0.6998820158397636,0.15497516596922492,0.7964249811260832,0.09885512609935272,6423]
["O14734","Acyl-coenzyme A thioesterase 8 [OS=Homo sapiens]",20,5,8,5,319,35.9,7.56,23.55,"cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle","other molecular function","ACOT8","ENSG00000101473","Primary bile acid biosynthesis; Metabolic pathways; Peroxisome","Peroxisomal protein import; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of pristanoyl-CoA; Beta-oxidation of very long chain fatty acids","",616.1,646.6,725.6,571,491.8,526,1.2514476334340383,0.3235979230153259,0.028859747406740084,1.5397074743630728,0.17951990961350067,0.7458873790868548,1175]
["O14735","CDP-diacylglycerol--inositol 3-phosphatidyltransferase [OS=Homo sapiens]",25,5,18,5,213,23.5,8.03,34.86,"other metabolic processes","plasma membrane;other membranes;ER/Golgi","other molecular function","CDIPT","ENSG00000103502","Inositol phosphate metabolism; Glycerophospholipid metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of PI","Glycerolipids and glycerophospholipids; 16p11.2 proximal deletion syndrome",1562.6,1587.4,1669.5,1314.8,1364.5,1431.9,1.1722854640980733,0.22932392427477516,0.007284599535078493,2.137594318222895,0.0964549601483491,1.015675434068121,552]
["O14744","Protein arginine N-methyltransferase 5 [OS=Homo sapiens]",37,21,49,21,637,72.6,6.29,162.74,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","PRMT5","ENSG00000100462","","snRNP Assembly; RMTs methylate histone arginines; Regulation of TP53 Activity through Methylation","Transcription co-factors SKI and SKIL protein partners; Nitric oxide metabolism in cystic fibrosis",6667.5,6831.7,6922,6239.4,6233.2,6015.1,1.1045830471069957,0.1435018905314341,3.5499042981668614E-3,2.4497833549275203,0.06864087437910474,1.1634171928807724,378]
["O14745","Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [OS=Homo sapiens]",69,21,108,21,358,38.8,5.77,328.28,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;transporter activity;cytoskeletal activity;other molecular function","SLC9A3R1","ENSG00000109062","Tight junction; Parathyroid hormone synthesis, secretion and action; Pathogenic Escherichia coli infection; Human papillomavirus infection","","",13673.7,11634.6,12736.4,14842,14667.6,15476.2,0.8457046445767331,-0.24177419301154315,0.02227813454880073,1.6521211774606146,0.15762912431479625,0.8023635370962622,1033]
["O14757","Serine/threonine-protein kinase Chk1 [OS=Homo sapiens]",4,2,2,2,476,54.4,8.25,5.21,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","CHEK1","ENSG00000149554","Cell cycle; p53 signaling pathway; Cellular senescence; Human T-cell leukemia virus 1 infection; Human immunodeficiency virus 1 infection; Viral carcinogenesis","Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Transcriptional Regulation by E2F6; Signaling by SCF-KIT; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex","miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; ATR signaling; ATM signaling in development and disease ; DNA repair pathways, full network; DNA damage response",178,191.3,186.9,468.5,406.6,199.1,0.517780673989946,-0.9495869768088472,0.10168237269259757,0.9927543283541281,0.3255350249716144,0.48740227796039043,2283]
["O14772","fucose-1-phosphate guanylyltransferase [OS=Homo sapiens]",3,1,1,1,594,66.6,6.48,3.55,"","","other molecular function","FPGT","ENSG00000254685","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars","","",34.1,36.7,35.2,39.5,25.4,45,0.964513193812557,-0.05212712149866946,0.8359929317973045,0.07779739444424252,0.8883792292100172,0.05140160404626424,6878]
["O14773","Tripeptidyl-peptidase 1 [OS=Homo sapiens]",32,10,45,10,563,61.2,6.48,142.15,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","TPP1","ENSG00000166340","Lysosome","XBP1(S) activates chaperone genes","VEGFA-VEGFR2 signaling pathway",5462.7,5590.5,5664.3,5407.2,5617.3,6027.4,{"$f":"AVERAGE(S194:U194)/AVERAGE(V194:X194)","v":0.9803892821327828},{"$f":"LOG(Y194,2)","v":-0.028573382508806786},{"$f":"TTEST(V194:X194,S194:U194,2,2)","v":0.591557248259782},0.2280032199282953,{"$f":"AA194*7309/AE194","v":0.7179827179559526},0.14388600922106284,6022]
["O14776-1","Transcription elongation regulator 1 [OS=Homo sapiens]",25,33,92,33,1098,123.8,8.65,229.28,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","TCERG1","ENSG00000113649; ENSGGOG00000003329; ENSPTRG00000017375","Spliceosome","","",13101,11782.9,12762.4,13546.6,13575.3,13963.2,0.916300556649491,-0.12610719911397747,0.051581968931281925,{"$f":"-LOG10(AA195)","v":1.2875020844611507},0.23801301194364874,{"$f":"-LOG10(AC195)","v":0.6233992998306525},1584]
["O14777","Kinetochore protein NDC80 homolog [OS=Homo sapiens]",29,18,37,18,642,73.9,5.6,94.67,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","NDC80","ENSG00000080986","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",4592.5,4503.5,4372.8,5123.2,5579.2,3890,0.9230010142265836,-0.11559586173044213,0.5023087536564844,0.299029253392149,0.6564231504515009,0.18281611083642424,5593]
["O14782","Kinesin-like protein KIF3C [OS=Homo sapiens]",3,3,5,1,793,89.4,8.22,10.83,"transport;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF3C","ENSG00000084731","","Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins","",397.8,351.7,312.9,329.1,273.9,497.8,0.9651162790697676,-0.05122532335517294,0.8669482301952841,0.062006835640052896,0.9098972737646944,0.041007636201373494,6964]
["O14787-2","Isoform 2 of Transportin-2 [OS=Homo sapiens]",30,19,68,11,887,100.3,4.98,205.82,"","","","TNPO2","","","","",1717,1779.6,1818.6,1506.4,1518.2,1350.3,1.2149306269857596,0.28087393773148217,0.007069051840248405,2.15063883346796,0.09515230184231233,1.0215807011728337,543]
["O14795","Protein unc-13 homolog B [OS=Homo sapiens]",14,16,28,16,1591,180.6,5.99,85.29,"cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","UNC13B","ENSG00000198722","Synaptic vesicle cycle","Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle","Synaptic vesicle pathway; 16p11.2 proximal deletion syndrome; Monoamine transport",1810.9,1811.9,1814.7,1847.4,1900.7,2540.4,0.8646736105589569,-0.209772435304158,0.2716405129658527,0.5660054580829653,0.5071316754195191,0.29487926259295455,3915]
["O14802","DNA-directed RNA polymerase III subunit RPC1 [OS=Homo sapiens]",22,26,44,25,1390,155.5,8.48,120,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR3A","ENSG00000148606","RNA polymerase; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","Pyrimidine metabolism; Cytosolic DNA-sensing pathway",4710.9,4681.5,4712.3,4610.6,4636.6,4556,1.0218427610988756,0.03117321463619081,0.01757905404811737,1.7550044985873892,0.14292025143235804,0.8449062284366449,899]
["O14818-1","Proteasome subunit alpha type-7 [OS=Homo sapiens]",63,16,110,16,248,27.9,8.46,348.28,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","HEL-S-276; PSMA7","ENSG00000101182","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease",11723.5,11969.2,12682,12164.8,11610.6,8384.4,1.1310611384399156,0.17767691495119564,0.31127813305587543,0.5068513869523311,0.5373481045123745,0.2697442787517513,4234]
["O14828","Secretory carrier-associated membrane protein 3 [OS=Homo sapiens]",56,13,79,13,347,38.3,7.64,296.69,"transport","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SCAMP3","ENSG00000116521; ENSG00000263290","","","",5541.7,5871.2,5379.1,5118.4,5874.1,5729.6,1.0041800969973866,0.006018035966129626,0.9361139148638051,0.028671299139568673,0.9580028848697216,0.01863318311235884,7142]
["O14832","Phytanoyl-CoA dioxygenase, peroxisomal [OS=Homo sapiens]",5,2,2,2,338,38.5,8.47,4.08,"other metabolic processes","cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","PHYH","ENSG00000107537","Peroxisome","TYSND1 cleaves peroxisomal proteins; Alpha-oxidation of phytanate","",188.6,187.7,176.6,169.8,191.3,148.7,1.084542958022754,0.11708719832966745,0.3274518475412202,0.48485255486201284,0.5458028628685926,0.2629641906800992,4385]
["O14836","Tumor necrosis factor receptor superfamily member 13B [OS=Homo sapiens]",7,1,1,1,293,31.8,7.94,4.71,"developmental processes;signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","TNFRSF13B","ENSG00000240505","Cytokine-cytokine receptor interaction; Intestinal immune network for IgA production; Primary immunodeficiency","TNFs bind their physiological receptors","",47.4,39.6,45.4,60.8,62.7,176.9,0.440745672436751,-1.1819816907070542,0.21907286434407208,0.6594114133816664,0.46051296102698386,0.33675814218095185,3477]
["O14867","Transcription regulator protein BACH1 [OS=Homo sapiens]",9,6,6,6,736,81.9,5.05,18.29,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","BACH1","ENSG00000156273","","Heme signaling; Regulation of HMOX1 expression and activity; Regulation of BACH1 activity","Integrated cancer pathway; Ferroptosis",241.2,207.8,240.9,314.9,280.4,374.4,0.711457151696401,-0.4911512234435112,0.034506925376224844,1.4620937353369128,0.19296948552014337,0.7145113610334842,1307]
["O14874","[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial [OS=Homo sapiens]",24,7,11,7,412,46.3,8.82,34.8,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","kinase activity;other molecular function","BCKDK","ENSG00000103507","","Branched-chain amino acid catabolism","Thiamine metabolic pathways",1253,1331.3,1233.2,1556.8,1344.9,1617.2,0.8447852353448848,-0.24334347453860042,0.05626940963960855,1.2497276412989187,0.24790422848456836,0.6057160654393063,1659]
["O14880","Microsomal glutathione S-transferase 3 [OS=Homo sapiens]",38,4,23,4,152,16.5,9.38,79.97,"other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","MGST3","ENSG00000143198","Glutathione metabolism; Metabolism of xenobiotics by cytochrome P450; Drug metabolism; Drug metabolism; Metabolic pathways; Platinum drug resistance; Pathways in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Chemical carcinogenesis; Hepatocellular carcinoma; Fluid shear stress and atherosclerosis","Aflatoxin activation and detoxification; Glutathione conjugation","Nuclear receptors meta-pathway; NRF2 pathway; Metapathway biotransformation Phase I and II",3464.3,3687,3433,3059.4,3020.6,1386.6,1.417552835293172,0.503402508567776,0.13550136036605562,0.8680563446677626,0.3709286303054309,0.4307096441483649,2670]
["O14893","Gem-associated protein 2 [OS=Homo sapiens]",14,3,6,3,280,31.6,5.58,17.9,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","","GEMIN2","ENSG00000092208","","snRNP Assembly","",365.1,504.4,549.7,461.3,546.8,1025.1,0.6980129844579973,-0.5186742211473804,0.32836973263627595,0.48363688064773697,0.545963233812225,0.2628366025152169,4396]
["O14920-1","Inhibitor of nuclear factor kappa-B kinase subunit beta [OS=Homo sapiens]",26,12,24,12,756,86.5,5.78,76.67,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","IKBKB","ENSG00000104365","Antifolate resistance; MAPK signaling pathway; Ras signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; FoxO signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; TNF signaling pathway; Neurotrophin signaling pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; Alcoholic liver disease; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Chagas disease; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Pancreatic cancer; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; CLEC7A (Dectin-1) signaling; IKK complex recruitment mediated by RIP1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation","Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNAs involvement in the immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Nonalcoholic fatty liver disease; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; Insulin signaling; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; T-cell receptor (TCR) signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway",1784.8,1727.6,1838.7,1795.6,1692.1,1936.7,0.9864869847356389,-0.019628078080664284,0.7691979925110792,0.11396185787414337,0.8436476781607861,0.07383888438890153,6664]
["O14929","histone acetyltransferase type B catalytic subunit [OS=Homo sapiens]",44,14,93,14,419,49.5,5.69,261.91,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","mitochondrion;nucleus;other cell component","other molecular function","HAT1","ENSG00000128708","Neutrophil extracellular trap formation; Alcoholism","HATs acetylate histones","Ethanol effects on histone modifications",10708,10750.3,11576.5,10441.6,9834.6,9981.5,1.0917815960895905,0.12668428322457073,0.05140276872100978,1.2890134878554593,0.23748599025402053,0.6243620051331441,1582]
["O14933","Ubiquitin/ISG15-conjugating enzyme E2 L6 [OS=Homo sapiens]",15,2,3,2,153,17.8,7.88,9.18,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","UBE2L6","ENSG00000156587","Ubiquitin mediated proteolysis; Parkinson disease; Pathways of neurodegeneration","Antigen processing: Ubiquitination & Proteasome degradation; Amyloid fiber formation; ISG15 antiviral mechanism; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling","Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway; 7q11.23 copy number variation syndrome",429.5,365,362.2,619.4,783.5,462.4,0.6201147268535891,-0.689392943015564,0.06826772143208673,1.1657845923290109,0.269130947112795,0.5700363602535162,1854]
["O14936","peripheral plasma membrane protein CASK [OS=Homo sapiens]",6,5,8,5,926,105.1,6.43,25.47,"cell adhesion;protein metabolism;other metabolic processes;transport;other biological processes","extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","CASK","ENSG00000147044","","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Assembly and cell surface presentation of NMDA receptors; Nephrin family interactions; Neurexins and neuroligins; Dopamine Neurotransmitter Release Cycle; Syndecan interactions","Parkin-ubiquitin proteasomal system pathway; Splicing factor NOVA regulated synaptic proteins",827,771,815.7,609.2,608.6,881.8,1.1495999237950083,0.20113187127412988,0.32120978430650665,0.49321123423518,0.541573774739621,0.26634237416343615,4335]
["O14949","Cytochrome b-c1 complex subunit 8 [OS=Homo sapiens]",30,4,17,4,82,9.9,10.08,40.67,"other metabolic processes;transport;developmental processes","other membranes;mitochondrion","","UQCRQ","ENSG00000164405","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly",3748.5,3402.9,3003.7,3560.8,4564.9,2446,0.9605929036957157,-0.05800294406845411,0.8409590927294002,0.07522512933167216,0.8918412665059758,0.04971243622369011,6892]
["O14950","Myosin regulatory light chain 12B [OS=Homo sapiens]",66,11,109,11,172,19.8,4.84,318.93,"other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYL12B","ENSG00000118680","Axon guidance; Focal adhesion; Tight junction; Platelet activation; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Shigellosis; Salmonella infection","RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs","Thyroid stimulating hormone (TSH) signaling pathway; Focal adhesion",8443.9,6542,7680.5,8901,9224.1,9556.3,0.8188314174861099,-0.28836163715006163,0.045830902288046996,1.3388415925727446,0.22451612923816053,0.6487524538254216,1492]
["O14964","Hepatocyte growth factor-regulated tyrosine kinase substrate [OS=Homo sapiens]",26,19,36,19,777,86.1,6.16,92.11,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","HGS","ENSG00000185359","Endocytosis; Phagosome","Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; Endosomal Sorting Complex Required For Transport (ESCRT); Ub-specific processing proteases; RHOU GTPase cycle; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Inhibition of membrane repair; Prevention of phagosomal-lysosomal fusion; RHOBTB3 ATPase cycle","TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway",4163.2,4292.2,4066.2,4465.3,4814.4,6327.4,0.8023015166174368,-0.3177835704522309,0.14828787190939333,0.82889436736821,0.385569568049006,0.41389725109167774,2811]
["O14965","Aurora kinase A [OS=Homo sapiens]",15,5,6,5,403,45.8,9.39,16.59,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","AURKA","ENSG00000087586","Oocyte meiosis; Progesterone-mediated oocyte maturation","APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; SUMOylation of DNA replication proteins; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Interaction between PHLDA1 and AURKA","Integrated breast cancer pathway; Gastric cancer network 1; EGF/EGFR signaling pathway",499.4,515.5,516.2,536.9,485.6,846.2,0.8193396478835554,-0.2874664662939184,0.3747702553167428,0.4262348854054589,0.5717377992298212,0.24280309437963127,4791]
["O14967","calmegin [OS=Homo sapiens]",22,10,25,9,610,70,4.69,63.37,"cell organization and biogenesis;stress response;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","CLGN","ENSG00000153132","","","",1646.6,1814.8,1692.6,1482,1599.7,1672.4,1.0841168675459076,0.11652028726452154,0.1493518781715201,0.8257893115640481,0.3865484693893911,0.41279604205984133,2824]
["O14972","Down syndrome critical region protein 3 [OS=Homo sapiens]",16,3,8,3,297,33,7.68,19.29,"transport","other cytoplasmic organelle","","VPS26C","ENSG00000157538","","","",524.5,532.9,571.1,534.5,480.3,399,1.1518602348281228,0.20396567272368465,0.16285604320658334,0.7881961211483778,0.4022692868526251,0.3954831244250378,2959]
["O14974","Protein phosphatase 1 regulatory subunit 12A [OS=Homo sapiens]",51,50,148,3,1030,115.2,5.4,403.41,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP1R12A","ENSG00000058272","cGMP-PKG signaling pathway; cAMP signaling pathway; Vascular smooth muscle contraction; Focal adhesion; Platelet activation; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Proteoglycans in cancer","Regulation of PLK1 Activity at G2/M Transition; RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs","Focal adhesion; Hippo-Merlin signaling dysregulation; Regulation of actin cytoskeleton",20176.6,19461.5,20431,22099,22183.2,14814.9,1.0164475075765138,0.023535711971143514,0.9015498701154805,0.04501024485180829,0.9337435171707591,0.029772400401969226,7057]
["O14974-4","Isoform 4 of Protein phosphatase 1 regulatory subunit 12A [OS=Homo sapiens]",53,48,152,1,971,109,5.41,415.41,"","","","PPP1R12A","","","","",546.3,580.1,594.8,615.7,604.8,512.4,0.9932483120780196,-0.009773658281755374,0.9184424301058131,0.03694806099230529,0.9458779373881059,0.024164904337219243,7097]
["O14975","very long-chain acyl-CoA synthetase [OS=Homo sapiens]",23,11,29,11,620,70.3,8.51,72.21,"other metabolic processes;transport","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","transporter activity;other molecular function","SLC27A2","ENSG00000140284","PPAR signaling pathway; Peroxisome; Insulin resistance","Peroxisomal protein import; Neutrophil degranulation; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Alpha-oxidation of phytanate; Synthesis of bile acids and bile salts via 24-hydroxycholesterol","PPAR signaling pathway",2511.8,2440.2,2560.7,2091.2,2281.9,3344.1,0.973500751567926,-0.03874600214322919,0.8701734182657477,0.060394187507136494,0.9121034725518931,0.0399558908280818,6973]
["O14976","Cyclin-G-associated kinase [OS=Homo sapiens]",23,22,59,22,1311,143.1,5.73,183.19,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;ER/Golgi;other cell component","kinase activity;other molecular function","GAK","ENSG00000178950","","Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis","",5133.4,5597.3,5218.7,5640.1,5590.7,6262.5,0.9117433531694994,-0.13330031788490546,0.1177981870686469,0.9288613933531733,0.3468924050301129,0.4598052086319113,2482]
["O14979-1","Heterogeneous nuclear ribonucleoprotein D-like [OS=Homo sapiens]",30,15,127,13,420,46.4,9.57,302.04,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","HNRNPDL; HNRPDL","ENSG00000152795; ENSPPAG00000043177; ENSPTRG00000016217","","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","",11930.3,12022.5,11833.2,12641.1,14005.7,8899.1,1.006754646808774,0.009712131248159494,0.9607249204356253,0.017400943900908544,0.9732416415057499,0.011779317446448584,7215]
["O14980","Exportin-1 [OS=Homo sapiens]",47,39,166,39,1071,123.3,6.06,503.63,"transport;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","XPO1","ENSG00000082898","Ribosome biogenesis in eukaryotes; Nucleocytoplasmic transport; Influenza A; Human T-cell leukemia virus 1 infection","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; MAPK6/MAPK4 signaling; Deactivation of the beta-catenin transactivating complex; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Heme signaling; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Downregulation of TGF-beta receptor signaling; HuR (ELAVL1) binds and stabilizes mRNA; Cyclin A/B1/B2 associated events during G2/M transition","eIF5A regulation in response to inhibition of the nuclear export system; 22q11.2 copy number variation syndrome",17042.8,18031.9,17598.1,16609.7,15939.8,14510.8,1.1192618831584158,0.16254763535801645,0.051726824261409184,1.2862841840321095,0.23823021961350957,0.6230031489029847,1587]
["O14981","TATA-binding protein-associated factor 172 [OS=Homo sapiens]",15,20,44,20,1849,206.8,6.52,146.79,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","BTAF1","ENSG00000095564","","","",3132.7,3174.9,3146,3293.8,3497.7,3862.9,0.8872953896981529,-0.17251362248195812,0.07453939391131509,1.1276141428679525,0.28025125005030965,0.5524524415742352,1944]
["O14986","Phosphatidylinositol 4-phosphate 5-kinase type-1 beta [OS=Homo sapiens]",5,2,3,1,540,61,6.86,6.4,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","kinase activity;other molecular function","PIP5K1B","ENSG00000107242","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Phospholipase D signaling pathway; Endocytosis; Focal adhesion; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Yersinia infection; Choline metabolism in cancer","Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; WNT mediated activation of DVL","B cell receptor signaling pathway; Wnt signaling pathway; Regulation of actin cytoskeleton",31.1,36.3,37.4,40,37.5,56.3,0.7832585949177878,-0.3524393991040105,0.19433203368109328,0.7114556044221423,0.4350299645253019,0.361480828149262,3265]
["O15014","zinc finger protein 609 [OS=Homo sapiens]",1,1,1,1,1411,151.1,8.03,2.25,"developmental processes;other biological processes","nucleus","other molecular function","ZNF609","ENSG00000180357","","","",115.1,102,111.2,191,173.3,185.5,0.5971262277191707,-0.7438921569399725,3.4545586645468582E-4,3.4616074278251725,0.02451395075647863,1.6105866906463717,103]
["O15015","Zinc finger protein 646 [OS=Homo sapiens]",1,1,1,1,1829,200.6,7.33,3.44,"","","","","","","","",93.2,96.8,95.4,117.5,116.3,257.6,0.5807895807895807,-0.7839125228864018,0.21711703014755046,0.6633061101750903,0.45811442648627204,0.33902603163642636,3464]
["O15020","Spectrin beta chain, non-erythrocytic 2 [OS=Homo sapiens]",13,30,70,16,2390,271.2,6.11,202.36,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SPTBN2","ENSG00000173898","Spinocerebellar ataxia; Pathways of neurodegeneration","MHC class II antigen presentation; COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins","",910.5,968.5,929.1,907,941.9,2017.4,0.7263016320513151,-0.46135927298756485,0.38840460830480766,0.4107156259589965,0.5803044321545051,0.23634411243927145,4892]
["O15027-5","Isoform 5 of Protein transport protein Sec16A [OS=Homo sapiens]",22,34,83,34,2201,235.6,5.67,232.92,"","","","","","","","",7125,6825.2,7353.7,7680.2,7940.7,10692,0.8096370981533773,-0.304652698017575,0.16214733242447896,0.7900901917511594,0.4016044909151192,0.39620143936714586,2951]
["O15031","Plexin-B2 [OS=Homo sapiens]",6,10,18,9,1838,205,6.24,46.43,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","PLXNB2","ENSG00000196576","Axon guidance","","",771.2,830.1,743.5,748.7,678.7,1592.7,0.7763981325121684,-0.3651314469783331,0.48768188707569166,0.31186337417910787,0.6469086955782632,0.18915701114691993,5510]
["O15037","protein KHNYN [OS=Homo sapiens]",7,4,4,4,678,74.5,7.02,12.78,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KHNYN","ENSG00000100441","","","",328.7,312.8,288.5,320.6,326.6,443.7,0.8525071042258684,-0.23021623824178455,0.2681807792985526,0.5715723515541563,0.5044089850471233,0.2972171859339471,3886]
["O15042-2","Isoform 2 of U2 snRNP-associated SURP motif-containing protein [OS=Homo sapiens]",31,24,78,1,1028,118.2,8.47,207.63,"","","","U2SURP","","","","",6855.5,6819,6857.1,7732.4,7754.8,5273.8,0.9889504359134915,-0.016029876889470347,0.9304734567518866,0.03129601130334562,0.953833169060244,0.02052757927123822,7130]
["O15047","Histone-lysine N-methyltransferase SETD1A [OS=Homo sapiens]",6,8,12,8,1707,185.9,5.14,36.58,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SETD1A","ENSG00000099381","Lysine degradation; Metabolic pathways","PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","Histone modifications",663.5,671.8,699,645.7,674.9,1386.3,0.7515238834090658,-0.4121091412070663,0.40732878578558085,0.3900548973873979,0.5912941599417697,0.22819641039306174,5035]
["O15050","TPR and ankyrin repeat-containing protein 1 [OS=Homo sapiens]",1,1,1,1,2925,336,6.76,0,"","","","TRANK1","ENSG00000168016","","","",27.1,31,36.6,30.9,24.4,35.5,1.0429515418502202,0.06067212817746994,0.7743897050761539,0.11104042927706113,0.8462940123208148,0.07247873182404811,6688]
["O15056","Synaptojanin-2 [OS=Homo sapiens]",3,4,4,4,1496,165.4,7.34,11.76,"cell organization and biogenesis;other metabolic processes;transport;developmental processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity;other molecular function","SYNJ2","ENSG00000078269","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane","",330.4,337,325.6,394.9,354,683.2,0.6933873332867817,-0.5282666130787459,0.2307481858849277,0.6368617046607176,0.4696570567064708,0.3282191479028177,3591]
["O15061-1","Synemin [OS=Homo sapiens]",4,5,5,5,1565,172.7,5.16,13.83,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SYNM","ENSG00000182253","","","",167.4,151.5,178.3,159.9,165.8,252.1,0.8605053651782621,-0.2167439075121309,0.4322512633110614,0.36426372876954904,0.6066291251037917,0.21707674244571165,5208]
["O15062","zinc finger and BTB domain-containing protein 5 [OS=Homo sapiens]",2,1,1,1,677,74.2,6.19,3.91,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB5","ENSG00000168795","","","",38.4,38.4,51.2,54.3,63.8,123.1,0.5306799336650083,-0.9140860970127225,0.16064156673394248,0.7941420688491451,0.3993636772987706,0.39863143737732937,2940]
["O15066","Kinesin-like protein KIF3B [OS=Homo sapiens]",18,11,14,9,747,85.1,7.69,41.08,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF3B","ENSG00000101350","","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins","",1162.8,1122.9,1154.2,1330.2,1336.7,1117.4,0.9089924160346694,-0.1376598372059512,0.19117785004928228,0.7185624266970279,0.43207139950841195,0.3644444803834372,3234]
["O15067","Phosphoribosylformylglycinamidine synthase [OS=Homo sapiens]",33,35,110,35,1338,144.6,5.76,331.34,"other metabolic processes;other biological processes","cytosol","other molecular function","PFAS","ENSG00000178921","Purine metabolism; Metabolic pathways","Purine ribonucleoside monophosphate biosynthesis","",13589.7,13889.5,13751,12803.2,13171.3,14186.5,1.0266228430566968,0.03790626696442298,0.4465182695034893,0.350160767050392,0.614267274948429,0.2116426210761562,5313]
["O15078-1","Centrosomal protein of 290 kDa [OS=Homo sapiens]",1,2,4,2,2479,290.2,5.95,10.65,"cell organization and biogenesis;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","CEP290","ENSG00000198707","","Neutrophil degranulation; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","Clear cell renal cell carcinoma pathways; Ciliary landscape; Joubert syndrome; Ciliopathies",1221.2,1127.4,1051.8,1358.8,1425.2,1782.5,0.744640315339976,-0.42538436807942837,0.05040447142353367,1.297530935212611,0.23570459477582062,0.6276319513478249,1563]
["O15084","serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A [OS=Homo sapiens]",14,11,22,9,1053,112.9,6.25,80.85,"","cytosol;nucleus","","ANKRD28","ENSG00000206560","","Telomere Extension By Telomerase; COPII-mediated vesicle transport","",1425.1,1492.2,1449.5,1468.1,1427.2,1690.3,0.9522854152128402,-0.0705340576993231,0.43454433811467785,0.3619659043335192,0.6082122878744122,0.21594480993647192,5222]
["O15085-1","Rho guanine nucleotide exchange factor 11 [OS=Homo sapiens]",1,2,2,2,1522,167.6,5.5,5.16,"cell organization and biogenesis;signal transduction;other biological processes","other membranes;cytosol;other cell component","signal transduction activity or receptor binding;enzyme regulator activity","ARHGEF11","ENSG00000132694","Vascular smooth muscle contraction; Parathyroid hormone synthesis, secretion and action; Pathogenic Escherichia coli infection; Human cytomegalovirus infection; Pathways in cancer","RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOB GTPase cycle; Sema4D induced cell migration and growth-cone collapse","",159,134,146.8,161.6,166.3,260.6,0.7473237043330502,-0.42019481107083845,0.20798522432899053,0.681967517057999,0.44922104155454834,0.347539909541012,3384]
["O15091","Mitochondrial ribonuclease P protein 3 [OS=Homo sapiens]",19,10,14,10,583,67.3,8.78,42.78,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus","other molecular function","PRORP","ENSG00000100890","","tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion","",1370.9,1317,1430,1204.9,1384.1,807.2,1.2125022083505093,0.2779873749067154,0.2380024644538942,0.6234185459132956,0.4758096314807201,0.3225667710911165,3656]
["O15111","Inhibitor of nuclear factor kappa-B kinase subunit alpha [OS=Homo sapiens]",8,4,5,4,745,84.6,6.73,16.69,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","CHUK","ENSG00000213341","Antifolate resistance; MAPK signaling pathway; Ras signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; FoxO signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; TNF signaling pathway; Adipocytokine signaling pathway; Alcoholic liver disease; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Chagas disease; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Chemical carcinogenesis; Pancreatic cancer; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Constitutive Signaling by AKT1 E17K in Cancer; IKK complex recruitment mediated by RIP1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; AKT phosphorylates targets in the cytosol","Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Canonical and non-canonical Notch signaling; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Chemokine signaling pathway; IL-4 signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNAs involvement in the immune response in sepsis; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - interferon induction; Neuroinflammation; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; T-cell receptor (TCR) signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway",379.7,383.1,402.6,363.1,333.5,503.5,0.9710857428547622,-0.04232940961358246,0.8376768199769088,0.07692350210016133,0.8897805373072557,0.05071709806258082,6881]
["O15116","U6 snRNA-associated Sm-like protein LSm1 [OS=Homo sapiens]",35,4,6,4,133,15.2,5.22,15.68,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","LSM1","ENSG00000175324","RNA degradation","mRNA decay by 5' to 3' exoribonuclease","",477.4,462.8,464.6,558.2,546.3,1157.9,0.620933521923621,-0.6874892752740407,0.2298694225061007,0.6385187952381938,0.4702254713397957,0.3276938495566607,3573]
["O15118","Niemann-Pick C1 protein [OS=Homo sapiens]",4,5,16,5,1278,142.1,5.36,47.77,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","NPC1","ENSG00000141458","Lysosome; Cholesterol metabolism","LDL clearance","Irinotecan pathway; Irinotecan pathway; Irinotecan pathway; Ebola virus pathway in host; Irinotecan pathway; Irinotecan pathway",1350.8,1365,1372.1,1239.9,1277.1,1189.6,1.1028705552258136,0.14126347062755826,0.008237954125241708,2.084180630831878,0.10102551459965041,0.9955689286881417,596]
["O15121","Sphingolipid delta(4)-desaturase DES1 [OS=Homo sapiens]",5,1,4,1,323,37.8,7.46,17.04,"cell organization and biogenesis;other metabolic processes;developmental processes","plasma membrane;other membranes;mitochondrion;ER/Golgi","other molecular function","DEGS1","ENSG00000143753","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway","Neutrophil degranulation; Sphingolipid de novo biosynthesis","Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway; Sphingolipid metabolism in senescence",277.2,255.2,302,240.3,276.3,244.9,1.0957321076822062,0.13189512114511115,0.24009348017805862,0.6196196332005207,0.4772486392769732,0.3212553011854101,3677]
["O15126-1","Secretory carrier-associated membrane protein 1 [OS=Homo sapiens]",12,4,6,4,338,37.9,7.42,21.87,"transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","SCAMP1","ENSG00000085365","","Neutrophil degranulation","",781.8,738.1,690.6,827.5,964.6,1194.7,0.7400897281371368,-0.4342279018607632,0.07889028277712282,1.1029764872363288,0.2888823030150254,0.5392790623037083,1996]
["O15127","Secretory carrier-associated membrane protein 2 [OS=Homo sapiens]",16,5,25,5,329,36.6,6.1,97.67,"transport","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","SCAMP2","ENSG00000140497","","","Serotonin transporter activity; Monoamine transport",2544.2,2594.8,2353.1,2190,2172.4,2220.4,1.1381327094853255,0.1866687897653876,0.015531967225486014,1.808773534544068,0.13482559198465235,0.8702276641597446,842]
["O15143","Actin-related protein 2/3 complex subunit 1B [OS=Homo sapiens]",51,17,75,16,372,40.9,8.35,254.53,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","ARPC1B","ENSG00000130429","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling","Pathogenic Escherichia coli infection; Microglia pathogen phagocytosis pathway",13393.4,13933.5,13117.7,12658,12872.7,9442.8,1.1564355869444007,0.20968491060542813,0.18332578246209816,0.7367764526940247,0.4272730051069756,0.36929454482245255,3136]
["O15144","Actin-related protein 2/3 complex subunit 2 [OS=Homo sapiens]",67,19,142,19,300,34.3,7.36,398.24,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity","ARPC2","ENSG00000163466","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling","Pathogenic Escherichia coli infection",20820.3,20899.8,22509.8,19720,17620.2,12857.7,1.2795336059875013,0.35561803917479545,0.09023640724579472,1.0446182044111278,0.30719045205380235,0.5125922869634035,2147]
["O15145","Actin-related protein 2/3 complex subunit 3 [OS=Homo sapiens]",31,6,26,6,178,20.5,8.59,47.95,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity","ARPC3","ENSG00000111229","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection","Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling","Pathogenic Escherichia coli infection",2321.9,1985.4,1734.1,2440.7,3381.1,1933.8,0.7789726133374594,-0.3603554871354256,0.27925449889537524,0.5539998215079758,0.5125743677615012,0.29024311531539343,3982]
["O15155","BET1 homolog [OS=Homo sapiens]",51,3,4,3,118,13.3,9.06,15.06,"cell organization and biogenesis;transport","other membranes;ER/Golgi","other molecular function","BET1","ENSG00000105829","SNARE interactions in vesicular transport","COPI-mediated anterograde transport; COPII-mediated vesicle transport","",222,223.6,223.5,209,215.8,338.3,0.8768182413838291,-0.18965028235507275,0.49725618774983693,0.30341980390209017,0.6537948329310233,0.18455851605667717,5559]
["O15156","Zinc finger and BTB domain-containing protein 7B [OS=Homo sapiens]",5,1,1,1,539,58,5.86,3.39,"RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZBTB7B","ENSG00000160685","","","Ectoderm differentiation; Ectoderm differentiation",18.1,19.3,17.9,14.9,15,26.6,0.9787610619469027,-0.030971387067842943,0.9234008747131215,0.03460971838905571,0.9492457093218292,0.022621357234849024,7110]
["O15160","DNA-directed RNA polymerases I and III subunit RPAC1 [OS=Homo sapiens]",37,9,25,9,346,39.2,5.5,78.2,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR1C","ENSG00000171453","RNA polymerase; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","Pyrimidine metabolism; Cytosolic DNA-sensing pathway",1459.4,1509.7,1529.2,1537.9,1599.4,1806.7,0.9098503236245955,-0.13629886290033646,0.15141113262836572,0.8198421918021205,0.3892592220825624,0.4097610896085897,2843]
["O15162","phospholipid scramblase 1 [OS=Homo sapiens]",3,1,1,1,318,35,4.94,2.06,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","extracellular matrix;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;transporter activity;nucleic acid binding activity;other molecular function","PLSCR1","ENSG00000188313","","","EGF/EGFR signaling pathway; Complement system in neuronal development and plasticity",34.6,38.5,35.6,35.3,25.5,18.6,1.3690176322418133,0.453141027884351,0.12162065357109741,0.9149926670838601,0.3524684206784897,0.45287978743694995,2522]
["O15164","Transcription intermediary factor 1-alpha [OS=Homo sapiens]",14,10,14,9,1050,116.8,7.11,36.53,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;kinase activity;other molecular function","TRIM24","ENSG00000122779","","Signaling by BRAF and RAF1 fusions; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease","",1070.2,1097.7,1075.2,1138,1105.9,2018.8,{"$f":"AVERAGE(S258:U258)/AVERAGE(V258:X258)","v":0.7608088770028388},{"$f":"LOG(Y258,2)","v":-0.394394015443277},{"$f":"TTEST(V258:X258,S258:U258,2,2)","v":0.3194509149438338},0.49559586366115965,{"$f":"AA258*7309/AE258","v":0.5408540044763681},0.26691995043345434,4317]
["O15173","Membrane-associated progesterone receptor component 2 [OS=Homo sapiens]",49,13,55,11,223,23.8,4.88,196.01,"transport;developmental processes;signal transduction","other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","PGRMC2","ENSG00000164040","","RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle","Ciliary landscape",5718.7,6044,5797.1,5516.9,5889.3,6640.6,0.9730146064676285,-0.03946663261453681,0.6622200201330971,{"$f":"-LOG10(AA259)","v":0.1789976938619596},0.768524313615879,{"$f":"-LOG10(AC259)","v":0.11434238827851179},6298]
["O15182","Centrin-3 [OS=Homo sapiens]",15,3,3,3,167,19.5,4.74,7.09,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","CETN3","ENSG00000153140","","","Breast cancer pathway",268.2,185.2,204.1,397.5,471.3,230.9,0.5978903337273802,-0.7420472082847734,0.12228858033289292,0.9126140967655857,0.3534231845208044,0.45170496422601747,2529]
["O15211","Ral guanine nucleotide dissociation stimulator-like 2 [OS=Homo sapiens]",3,2,2,2,777,83.5,6.18,5.85,"signal transduction;other biological processes","cytosol","enzyme regulator activity","RGL2","ENSG00000206282; ENSG00000224841; ENSG00000228736; ENSG00000237441; ENSG00000237825","Ras signaling pathway","RAF/MAP kinase cascade","Ras signaling",134,143.7,154.3,153.2,163.6,520.7,0.5158208955223881,-0.9550578780690286,0.3263377489183823,0.4863326865592803,0.5453138104354037,0.26335350337692565,4374]
["O15213","WD repeat-containing protein 46 [OS=Homo sapiens]",21,11,15,11,610,68,9.67,46.35,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","WDR46","ENSG00000204221; ENSG00000206284; ENSG00000226916; ENSG00000227057; ENSG00000236222","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",813.3,779.6,843.2,1603.9,1703,2132.8,0.447837196904241,-1.1589537329304536,0.00359131000172205,2.4447471049751845,0.06871435812195409,1.1629525060029202,382]
["O15226","NF-kappa-B-repressing factor [OS=Homo sapiens]",32,22,55,22,690,77.6,8.79,152.72,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","NKRF","ENSG00000186416","","","Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Network map of SARS-CoV-2 signaling pathway",5333.8,5113.7,5094.4,5878.1,5708.8,5687.8,0.8996914562915709,-0.15249777210883234,0.00408231151239162,2.3890938582797174,0.07331109298297384,1.1348303056209648,407]
["O15228","Dihydroxyacetone phosphate acyltransferase [OS=Homo sapiens]",23,14,32,14,680,77.1,6.57,82.48,"cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;other cytoplasmic organelle","other molecular function","GNPAT","ENSG00000116906","Glycerophospholipid metabolism; Peroxisome","Peroxisomal protein import; Plasmalogen biosynthesis; Synthesis of PA","Triacylglyceride synthesis",3309.6,3358,3478.9,3477.7,2936.5,2952.2,1.0832870686709941,0.11541560459761271,0.23220395412217243,0.6341303890814289,0.4710459896416759,0.3269366893200245,3603]
["O15229","Kynurenine 3-monooxygenase [OS=Homo sapiens]",8,3,4,3,486,55.8,9.03,13.58,"other metabolic processes;stress response;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion","other molecular function","KMO","ENSG00000117009","Tryptophan metabolism; Metabolic pathways; Biosynthesis of cofactors","Tryptophan catabolism","Selenium micronutrient network; NAD biosynthesis II (from tryptophan)",246.8,245.3,232.1,243,241.8,478.7,0.751634665282823,-0.4118964897069059,0.3692422612334432,0.43268859808461646,0.5682863102453647,0.24543280578266177,4749]
["O15230","Laminin subunit alpha-5 [OS=Homo sapiens]",0,1,1,1,3695,399.5,7.02,3.56,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;other cell component","signal transduction activity or receptor binding;extracellular structural activity","LAMA5","ENSG00000130702","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Toxoplasmosis; Amoebiasis; Human papillomavirus infection; Pathways in cancer; Small cell lung cancer","Degradation of the extracellular matrix; ECM proteoglycans; Non-integrin membrane-ECM interactions; Interleukin-4 and Interleukin-13 signaling; Laminin interactions; MET activates PTK2 signaling","Alpha 6 beta 4 signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Complement system; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Inflammatory response pathway; Small cell lung cancer; Malignant pleural mesothelioma",15.7,16.6,18.3,14.3,20.3,64.6,0.5100806451612903,-0.9712027356925653,0.3653318185366667,0.4373125013081663,0.566682992717423,0.24665982120323854,4712]
["O15234","Protein CASC3 [OS=Homo sapiens]",17,9,11,9,703,76.2,6.48,19.86,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","CASC3","ENSG00000108349","Nucleocytoplasmic transport; mRNA surveillance pathway","Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","",1366.6,1405.8,1478.2,2220.8,2193.9,2484.5,0.616100417439703,-0.6987625817343863,8.5068514042608754E-4,3.070231153285749,0.03636057129458639,1.43936930179393,171]
["O15235","28S ribosomal protein S12, mitochondrial [OS=Homo sapiens]",30,3,14,3,138,15.2,10.29,40.07,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPS12","ENSG00000128626; ENSG00000283018","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1538.5,1511,1442.5,1434.4,1475.1,1304.3,1.066021168541459,0.09223608673363823,0.19043277486474547,0.7202583042816322,0.43212454252916005,0.3643910672173507,3221]
["O15243","Leptin receptor gene-related protein [OS=Homo sapiens]",17,2,4,2,131,14.2,6.51,9.3,"transport;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","signal transduction activity or receptor binding","LEPROT","ENSG00000213625","","","",394.4,398.8,425.7,398.2,378.5,603.9,0.8828770099956541,-0.17971561899300156,0.49981340425663884,0.30119210091738996,0.6550360716714674,0.183734783524978,5577]
["O15247","Chloride intracellular channel protein 2 [OS=Homo sapiens]",57,13,57,11,247,28.3,5.59,218.71,"other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","transporter activity;other molecular function","CLIC2","ENSG00000155962","","Stimuli-sensing channels; Ion homeostasis","",3276.4,2973.4,2745.8,3318.9,3663.7,3649.4,0.8460872836719338,-0.24112159321449758,0.04579958999658884,1.339138409834909,0.22451321481225206,0.6487580914039307,1491]
["O15254","Peroxisomal acyl-coenzyme A oxidase 3 [OS=Homo sapiens]",24,12,20,12,700,77.6,7.25,66.46,"other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle","other molecular function","ACOX3","ENSG00000087008","Fatty acid degradation; beta-Alanine metabolism; alpha-Linolenic acid metabolism; Propanoate metabolism; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Carbon metabolism; Fatty acid metabolism; PPAR signaling pathway; cAMP signaling pathway; Peroxisome; Alcoholic liver disease","Peroxisomal protein import; Beta-oxidation of pristanoyl-CoA","PPAR signaling pathway; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Omega-3 / omega-6 fatty acid synthesis",1156.3,1277.1,1243.3,1130.5,1084.8,1461.4,0.9999999999999998,-3.2034265038149176E-16,1,0,1,0,7309]
["O15258","Protein RER1 [OS=Homo sapiens]",24,4,18,4,196,22.9,9.54,56.74,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding","RER1","ENSG00000157916","","","",2363.4,2744.3,2445.9,2359.5,2446.1,1686.1,1.1635781074294869,0.21856805768695445,0.25499847027240546,0.5934624248768128,0.49176354069155975,0.3082436729609122,3790]
["O15260-1","surfeit locus protein 4 [OS=Homo sapiens]",21,5,34,5,269,30.4,7.78,61.06,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","","SURF4","ENSG00000148248; ENSG00000280951; ENSGGOG00000014456; ENSNLEG00000013096; ENSPTRG00000021519","","COPI-dependent Golgi-to-ER retrograde traffic; Neutrophil degranulation","",2680.3,2602,2712.3,2093.7,2134.9,1342.3,1.4350643522590603,0.5211154327918122,0.0358337121627143,1.4457081991385479,0.19560015100618283,0.7086308142665839,1339]
["O15264","Mitogen-activated protein kinase 13 [OS=Homo sapiens]",28,7,19,6,365,42.1,8.38,64.93,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","MAPK13","ENSG00000156711","Endocrine resistance; MAPK signaling pathway; Rap1 signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Oocyte meiosis; Cellular senescence; Adrenergic signaling in cardiomyocytes; VEGF signaling pathway; Osteoclast differentiation; Signaling pathways regulating pluripotency of stem cells; Platelet activation; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; TNF signaling pathway; Leukocyte transendothelial migration; Thermogenesis; Neurotrophin signaling pathway; Retrograde endocannabinoid signaling; Dopaminergic synapse; Inflammatory mediator regulation of TRP channels; GnRH signaling pathway; Progesterone-mediated oocyte maturation; Prolactin signaling pathway; Relaxin signaling pathway; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Alcoholic liver disease; Amyotrophic lateral sclerosis; Prion disease; Pathways of neurodegeneration; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Yersinia infection; Leishmaniasis; Chagas disease; Toxoplasmosis; Tuberculosis; Hepatitis B; Human cytomegalovirus infection; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Proteoglycans in cancer; Chemical carcinogenesis; PD-L1 expression and PD-1 checkpoint pathway in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","VEGFA-VEGFR2 Pathway; NOD1/2 Signaling Pathway; p38MAPK events; DSCAM interactions","Regulation of toll-like receptor signaling pathway; Parkinson's disease pathway; Retinoblastoma gene in cancer; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Angiopoietin-like protein 8 regulatory pathway; Oxidative damage response; Epithelial to mesenchymal transition in colorectal cancer; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Regulatory circuits of the STAT3 signaling pathway; Hepatitis B infection; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - apoptosis; Host-pathogen interaction of human coronaviruses - MAPK signaling; Toll-like receptor signaling pathway",1466.4,1493.5,1593.3,1598.6,1390.7,1556.8,1.0015617782274917,2.2514120578749595E-3,0.9761139820550189,0.010499466260330898,0.9832438113065234,0.007338778428396729,7256]
["O15269","serine palmitoyltransferase 1 [OS=Homo sapiens]",18,8,16,8,473,52.7,6.01,50.1,"other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","SPTLC1","ENSG00000090054","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway","Sphingolipid de novo biosynthesis","Sphingolipid pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway",1095.5,1139.3,1141.6,1210.2,1157.6,1512.7,0.8700940600438088,-0.2007567253930338,0.20680333367074696,0.6844424646925023,0.4481249824487073,0.3486008439977307,3373]
["O15270","Serine palmitoyltransferase 2 [OS=Homo sapiens]",11,5,12,5,562,62.9,7.78,29.59,"other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","SPTLC2","ENSG00000100596","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway","Sphingolipid de novo biosynthesis","Sphingolipid pathway; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway",585.8,587,598.4,586.7,582.6,993.7,0.8188626907073508,-0.2883065380677889,0.3925916931747135,0.4060588938510161,0.5825117103966668,0.23469533947012758,4926]
["O15287","Fanconi anemia group G protein [OS=Homo sapiens]",2,1,1,1,622,68.5,5.47,2.22,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus","nucleic acid binding activity","FANCG","ENSG00000221829","Fanconi anemia pathway","Fanconi Anemia Pathway","Retinoblastoma gene in cancer; DNA repair pathways, full network",25.4,24.1,29,26.2,31.8,37,0.8263157894736842,-0.27523485943932086,0.18567096550539175,0.7312560042120528,0.42931638306830383,0.36722253816765954,3161]
["O15294","UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit [OS=Homo sapiens]",12,12,22,12,1046,116.9,6.7,62.76,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component","other molecular function","OGT","ENSG00000147162","Other types of O-glycan biosynthesis; Insulin resistance","UCH proteinases; Regulation of necroptotic cell death; HATs acetylate histones","Ectoderm differentiation; Ectoderm differentiation",2536.3,2619.6,2601.2,3685.8,3531.2,4889.2,0.6407543242305594,-0.6421567850850116,0.028001295031625448,1.5528218825119655,0.1779664916401308,0.7496617609816043,1150]
["O15297","protein phosphatase 1D [OS=Homo sapiens]",7,3,3,3,605,66.6,8.94,10.35,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus","kinase activity;other molecular function","PPM1D","ENSG00000170836","p53 signaling pathway","Transcriptional regulation by RUNX2","ATM signaling in development and disease ; Genotoxicity pathway",163.2,142,157.4,139.4,134.1,768.7,0.4438687392055268,-1.1717949887953585,0.4111572149765963,0.3859920843491715,0.5930823138472354,0.2268850267558697,5067]
["O15305","Phosphomannomutase 2 [OS=Homo sapiens]",44,12,65,11,246,28.1,6.77,167.72,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","PMM2","ENSG00000140650","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars","Defective PMM2 causes PMM2-CDG (CDG-1a); Synthesis of GDP-mannose","Nephrotic syndrome",8110.8,8119.7,7760.6,8350,8145.3,7184.9,1.0131291120852022,0.01881804136072135,0.7975926996435603,0.09821882977040702,0.8631337047223544,0.06392192418582682,6754]
["O15315-1","Isoform 2 of DNA repair protein RAD51 homolog 2 [OS=Homo sapiens]",3,1,1,1,350,38.2,6.1,2.84,"","","","RAD51B","","","","",22,22.6,29.8,28.4,18.4,95.2,0.523943661971831,-0.9325164032840132,0.40514364910325007,0.39239096455899425,0.5899969976679926,0.22915019835707823,5019]
["O15320","Endoplasmic reticulum export factor CTAGE5 [OS=Homo sapiens]",31,22,47,22,804,90.9,5.22,160.23,"","","","","","","","",5533.5,5269.6,5560.6,5428.3,5866.5,4146.1,1.0597633557629413,0.0837421482014983,0.5890309285899249,0.22986190086096747,0.7164631481217775,0.1448061429902332,6009]
["O15321-1","Transmembrane 9 superfamily member 1 [OS=Homo sapiens]",5,2,3,2,606,68.8,7.17,10.15,"other metabolic processes;other biological processes","other membranes;other cytoplasmic organelle;other cell component","","TM9SF1","ENSCANG00000029500; ENSCCAG00000032112; ENSG00000100926; ENSG00000285465; ENSPPAG00000042444; ENSPTRG00000032568; ENSRBIG00000029944; ENSRROG00000042511","","","",263.2,289.4,283.9,303.7,288.8,221.4,1.0277675390097063,0.03951399192269265,0.7906495301612354,0.10201598280618862,0.8586712356535616,0.06617308514619248,6730]
["O15344-1","E3 ubiquitin-protein ligase Midline-1 [OS=Homo sapiens]",10,6,6,6,667,75.2,6.8,19.65,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","MID1","ENSCANG00000031338; ENSCCAG00000029160; ENSCJAG00000000987; ENSCSAG00000015273; ENSG00000101871; ENSMFAG00000037182; ENSMLEG00000034816; ENSMMUG00000020179; ENSMNEG00000026727; ENSPANG00000006683; ENSPPAG00000038224; ENSRBIG00000037000; ENSTSYG00000003295","Ubiquitin mediated proteolysis","Interferon gamma signaling","",379,381.6,392.4,346.4,354.8,455.9,0.9964566588886008,-5.121038810783715E-3,0.9710721864946286,0.012748484787136158,0.9799208354396299,0.008809008103878992,7243]
["O15347","High mobility group protein B3 [OS=Homo sapiens]",23,4,6,3,200,23,8.37,19.09,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","HMGB3","ENSG00000029993","","","",544.7,532.3,541.3,480.5,412.6,797.5,0.9572341180645925,-0.06305627606633193,0.8489837697536659,0.07110061219868385,0.8969676746356668,0.04722320799305358,6918]
["O15355","Protein phosphatase 1G [OS=Homo sapiens]",51,23,124,23,546,59.2,4.36,418.89,"protein metabolism;other metabolic processes;other biological processes","other membranes;nucleus;other cell component","other molecular function","PPM1G","ENSG00000115241","","","VEGFA-VEGFR2 signaling pathway; mRNA processing",16602.6,17237.7,16520.7,16651.6,18717.2,16347.2,0.9737992110758759,-0.03830376308026281,0.5927671271297897,0.22711588887149614,0.7188543109659254,0.14335911845543484,6027]
["O15357","Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 [OS=Homo sapiens]",25,21,39,20,1258,138.5,6.54,114.09,"cell adhesion;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","INPPL1","ENSG00000165458","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; B cell receptor signaling pathway; Fc gamma R-mediated phagocytosis; Insulin signaling pathway","Synthesis of PIPs at the plasma membrane; Interleukin receptor SHC signaling; Synthesis of IP3 and IP4 in the cytosol","EGF/EGFR signaling pathway; Insulin signaling",2896.4,2819.2,2925.8,2912.5,2956.6,3269,0.9456451559952289,-0.08062916684342689,0.2287197375944864,0.6406963559070278,0.46984613886399695,0.3280443377709611,3558]
["O15360","Fanconi anemia group A protein [OS=Homo sapiens]",2,2,2,2,1455,162.7,6.6,5.6,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","","FANCA","ENSG00000187741","Fanconi anemia pathway","Fanconi Anemia Pathway","DNA repair pathways, full network",145.8,145.1,154.2,164.3,174.6,214.2,0.8047369372627011,-0.313410841263656,0.08075534128254538,1.0928287431415018,0.29248800269282665,0.5338919431584206,2018]
["O15371","Eukaryotic translation initiation factor 3 subunit D [OS=Homo sapiens]",58,23,96,23,548,63.9,6.05,317.05,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity","EIF3D","ENSG00000100353","","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","Translation factors; VEGFA-VEGFR2 signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell",8066.5,8206.3,8289.4,8291.1,8385.6,6068.7,1.0798754913081325,0.11086498051153464,0.47007113405232515,0.3278364169817007,0.6330845621500727,0.19853827667720392,5427]
["O15372","Eukaryotic translation initiation factor 3 subunit H [OS=Homo sapiens]",53,18,89,18,352,39.9,6.54,252.59,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3H","ENSG00000147677","Measles","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","Translation factors; VEGFA-VEGFR2 signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell",10793.6,10707.7,11103.6,11781.7,11401.3,13680.3,0.8844813133929952,-0.17709643174555706,0.11810810386378846,0.927720302703331,0.3471058026298472,0.4595381260892939,2487]
["O15379","Histone deacetylase 3 [OS=Homo sapiens]",11,5,13,5,428,48.8,5.16,34.32,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","HDAC3","ENSG00000171720","Neutrophil extracellular trap formation; Thyroid hormone signaling pathway; Alcoholism; Viral carcinogenesis","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Regulation of PTEN gene transcription; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Cytoprotection by HMOX1; Association of TriC/CCT with target proteins during biosynthesis; NR1D1 (REV-ERBA) represses gene expression; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RUNX2 regulates osteoblast differentiation; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; STAT3 nuclear events downstream of ALK signaling","Neural crest differentiation; Initiation of transcription and translation elongation at the HIV-1 LTR; Ethanol effects on histone modifications; Transcription co-factors SKI and SKIL protein partners; 22q11.2 copy number variation syndrome; IL-18 signaling pathway; 7q11.23 copy number variation syndrome; 16p11.2 proximal deletion syndrome",1261,1293.8,1320.5,1539.3,1480,1855,0.7950474939991383,-0.3308870491942599,0.047321594568753116,1.324940629624353,0.2282993628402749,0.641495300578704,1515]
["O15381-1","Nuclear valosin-containing protein-like [OS=Homo sapiens]",26,17,29,17,856,95,6.48,88.47,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","NVL","ENSG00000143748","Ribosome biogenesis in eukaryotes","","",2084.5,2077.2,2056,2484.4,2531,3403.3,0.7385582096998348,-0.43721646294836536,0.07013693748178801,1.1540532014399405,0.2720970679694207,0.5652761380128261,1884]
["O15382","Branched-chain-amino-acid aminotransferase, mitochondrial [OS=Homo sapiens]",49,14,34,14,392,44.3,8.65,113.66,"other metabolic processes;other biological processes","mitochondrion","other molecular function","BCAT2","ENSG00000105552","Cysteine and methionine metabolism; Valine, leucine and isoleucine degradation; Valine, leucine and isoleucine biosynthesis; Pantothenate and CoA biosynthesis; Metabolic pathways; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids; Biosynthesis of cofactors","Branched-chain amino acid catabolism","One-carbon metabolism and related pathways",4754.7,4603.4,4884.4,3826.9,4035.9,4161,1.1845256907134183,0.2443094889647299,0.004311894668384913,2.365331856703027,0.0748589979364022,1.1257559906547223,421]
["O15397-1","Importin-8 [OS=Homo sapiens]",10,8,19,7,1037,119.9,5.16,63.01,"transport;signal transduction","cytosol;nucleus","other molecular function","IPO8","ENSG00000133704","Nucleocytoplasmic transport","Transcriptional regulation by small RNAs","",1029.5,1036.4,994.2,1148.4,1290,1524.3,0.7722260075201253,-0.3729049517854253,0.0526791954467207,1.2783608665067197,0.24019478447915257,0.6194364269768916,1603]
["O15400","Syntaxin-7 [OS=Homo sapiens]",62,11,84,11,261,29.8,5.55,223.5,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","STX7","ENSG00000079950","SNARE interactions in vesicular transport; Phagosome","","",3890,3915.9,3867.4,4546.6,5216.7,6621.1,0.7124642953052903,-0.489110378654821,0.06207717072317346,1.2070680850377884,0.25794317272067924,0.5884759626112768,1759]
["O15427","Monocarboxylate transporter 4 [OS=Homo sapiens]",3,2,4,2,465,49.4,7.96,10.11,"transport","plasma membrane;other membranes;nucleus;other cell component","transporter activity","SLC16A3","ENSG00000141526","Central carbon metabolism in cancer","Pyruvate metabolism; Basigin interactions; Proton-coupled monocarboxylate transport","Metabolic reprogramming in colon cancer",445.6,465.3,413.3,476.6,468.5,567.5,0.8754462514875051,-0.19190948857892556,0.14870913068224317,0.8276623651486942,0.3858413333888943,0.41359125025049465,2817]
["O15439-1","multidrug resistance-associated protein 4 [OS=Homo sapiens]",8,7,13,6,1325,149.4,8.19,35.69,"cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes","transporter activity;other molecular function","ABCC4","ENSG00000125257","Antifolate resistance; ABC transporters; cAMP signaling pathway; Bile secretion","ABC-family proteins mediated transport; Platelet degranulation","Fluoropyrimidine activity; Drug induction of bile acid pathway; Ectoderm differentiation; Pregnane X receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; TYROBP causal network in microglia; Aspirin and miRNAs; Proximal tubule transport; FOXA2 pathway; Prostaglandin synthesis and regulation",538.2,499.4,521,425.6,426.8,604.3,1.069952632662868,0.09754692921052865,0.6040028062633279,0.2189610435943535,0.7270514675524808,0.13843484459780447,6072]
["O15446-1","DNA-directed RNA polymerase I subunit RPA34 [OS=Homo sapiens]",17,3,3,3,510,55,8.51,13.7,"RNA metabolism OR transcription;other metabolic processes;signal transduction","cytosol;mitochondrion;nucleus;other cell component","other molecular function","POLR1G","ENSG00000117877","RNA polymerase","B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","",55.3,53,56.7,66.1,46,54.9,0.9880239520958084,-0.017382078228236415,0.9156807864016686,0.03825589845630628,0.9439648614682363,0.025044171755399885,7090]
["O15498","Synaptobrevin homolog YKT6 [OS=Homo sapiens]",38,8,44,8,198,22.4,6.92,123.61,"cell organization and biogenesis;transport","plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","YKT6","ENSG00000106636","SNARE interactions in vesicular transport","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; COPI-mediated anterograde transport; RAC3 GTPase cycle; Intra-Golgi traffic; COPII-mediated vesicle transport","",7180.5,7731.7,7099.7,5781,6097,5020.4,1.3026026132651611,0.3813970261066015,0.01056871411099121,1.9759778498234053,0.11195178469164456,0.9509689786766876,690]
["O15504","nucleoporin-like protein 2 [OS=Homo sapiens]",7,2,4,2,423,44.8,9.19,8.16,"transport","other membranes;cytosol;nucleus","other molecular function","NUP42","ENSG00000136243","Nucleocytoplasmic transport","HCMV Early Events; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus","",168.1,165.8,157.8,204.4,190.6,228.6,0.7884862091084028,-0.3428425728771697,0.01892011914819284,1.7230761329849793,0.14727066118651913,0.8318837633671173,939]
["O15511-1","Actin-related protein 2/3 complex subunit 5 [OS=Homo sapiens]",58,9,39,9,151,16.3,5.67,142.68,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity","Arpc5; ARPC5","ENSDLEG00000020693; ENSG00000162704; ENSGGOG00000007894; ENSPCTG00005002795; ENSPPAG00000038421; ENSPPYG00000000425; ENSPTRG00000001767; ENSRNOG00000028062; ENSSBOG00000027275; ENSSSCG00000015560; ENSSSCG00070012419; ENSSTOG00000001001","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection","Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; EPHB-mediated forward signaling; Neutrophil degranulation; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling","Pathogenic Escherichia coli infection; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton",4101.2,3875,3818.5,4410.4,4453.8,3513.1,0.9529299604921913,-0.0695579136628208,0.5750024493610166,0.24033030532479024,0.7063349415764152,0.15098930916936687,5950]
["O15527-1","N-glycosylase/DNA lyase [OS=Homo sapiens]",3,1,1,1,345,38.8,8.6,3.08,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","OGG1","ENSG00000114026","Base excision repair","Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Displacement of DNA glycosylase by APEX1; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; Defective OGG1 Substrate Binding; Defective OGG1 Substrate Processing","Base excision repair; DNA repair pathways, full network",104,105.5,115.8,121,102,130.6,0.9199660633484162,-0.12034745235029978,0.36247004641591235,0.44072787657924767,0.5650018275226921,0.24795014743412405,4689]
["O15530-1","3-phosphoinositide-dependent protein kinase 1 [OS=Homo sapiens]",25,10,18,10,556,63.1,7.36,46.45,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function","PDPK1","ENSG00000140992","Platinum drug resistance; PPAR signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Apoptosis; Axon guidance; Focal adhesion; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; Neurotrophin signaling pathway; Insulin signaling pathway; Thyroid hormone signaling pathway; Insulin resistance; Aldosterone-regulated sodium reabsorption; Toxoplasmosis; Proteoglycans in cancer; Chemical carcinogenesis; Endometrial cancer; Prostate cancer; Non-small cell lung cancer; Choline metabolism in cancer; Lipid and atherosclerosis","Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of TP53 Degradation; PIP3 activates AKT signaling; GPVI-mediated activation cascade; CD28 dependent PI3K/Akt signaling; G beta:gamma signalling through PI3Kgamma; RHO GTPases activate PKNs; Activation of AKT2; Integrin signaling; RSK activation; VEGFR2 mediated vascular permeability; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ","MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac hypertrophic response; Focal adhesion; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; PPAR signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; EGF/EGFR signaling pathway; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Modulators of TCR signaling and T cell activation; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway",2031,2030.2,2086.2,1819.7,1788.2,2346.4,1.032430344456947,0.046044449832206055,0.7414334135098113,0.12992784590836604,0.8249561302090441,0.08356914589215134,6569]
["O15533-1","Tapasin [OS=Homo sapiens]",11,5,40,5,448,47.6,7.15,107.11,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;ER/Golgi","signal transduction activity or receptor binding;transporter activity;other molecular function","TAPBP","ENSG00000112493; ENSG00000206208; ENSG00000206281; ENSG00000231925; ENSG00000236490; ENSPPAG00000024524; ENSPTRG00000018043","Antigen processing and presentation; Human cytomegalovirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection","ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC","",4914.9,5065.1,4858.7,4419.3,4543.7,7375.9,0.9081823133748295,-0.13894615397942586,0.6324912169745824,0.19894550089674118,0.7482807227043093,0.12593544297820003,6178]
["O15534-1","period circadian protein homolog 1 [OS=Homo sapiens]",2,2,2,2,1290,136.1,6.09,0,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PER1","ENSG00000179094","Circadian rhythm; Circadian entrainment","Circadian Clock","Melatonin metabolism and effects; Exercise-induced circadian regulation",168.5,184.5,195.1,132.4,132.6,290.1,0.9873896595208072,-0.018308558412937645,0.9670560854892247,0.014548337796886692,0.9773524514436869,9.948793380220625E-3,7232]
["O15541","RING finger protein 113A [OS=Homo sapiens]",29,7,14,7,343,38.8,5.69,43.22,"protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus","other molecular function","RNF113A","ENSG00000125352","","","",1306.6,1358.9,1305.9,1317.8,1347.3,1185,1.0315056751772682,0.04475175872083747,0.4873514884054458,0.31215770323166414,0.6465877706943916,0.1893725137210126,5509]
["O15550","Lysine-specific demethylase 6A [OS=Homo sapiens]",3,4,5,4,1401,154.1,7.44,12.76,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","KDM6A","ENSG00000147050","Transcriptional misregulation in cancer","Activation of anterior HOX genes in hindbrain development during early embryogenesis; HDMs demethylate histones","Mesodermal commitment pathway; Mesodermal commitment pathway; Pathways affected in adenoid cystic carcinoma",593.8,575.1,601.3,676.6,656.1,724.5,0.8604899863892672,-0.2167696913152054,0.011635721489599429,1.9342066824900948,0.11714254596071931,0.9312853413062155,726]
["O15553","Pyrin [OS=Homo sapiens]",2,2,5,1,781,86.4,8.03,11.75,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","MEFV","ENSG00000103313","NOD-like receptor signaling pathway; Yersinia infection","The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection","Nucleotide-binding oligomerization domain (NOD) pathway",258.3,229.8,223.1,254.3,282.6,239.4,0.9161406672678087,-0.12635896338954425,0.2622375016916985,0.581305201230401,0.49784257139340893,0.30290796885492877,3850]
["O43143","Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 [OS=Homo sapiens]",41,32,171,32,795,90.9,7.46,501.7,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","DHX15","ENSG00000109606","Spliceosome","mRNA Splicing - Major Pathway","mRNA processing",19634.9,19312.2,19977.8,18872.9,18753.7,13842.8,1.144853058322032,0.1951624405631876,0.21056097222160827,0.6766221227968334,0.4511844461940003,0.34564588032025767,3411]
["O43148-1","mRNA cap guanine-N7 methyltransferase [OS=Homo sapiens]",41,18,47,18,476,54.8,6.61,140.64,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RNMT","ENSG00000101654","mRNA surveillance pathway","RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE","mRNA processing",5216.3,5189.3,5126,6097.7,6281.2,4832.5,0.9024018964174906,-0.14815799529201856,0.2869661563477063,0.542169319217656,0.5191672368181647,0.284692722444288,4040]
["O43149","Zinc finger ZZ-type and EF-hand domain-containing protein 1 [OS=Homo sapiens]",14,33,57,21,2961,330.9,5.95,161.32,"","","other molecular function","ZZEF1","ENSG00000074755","","","",4789.7,4777.5,4863.8,4537.7,4605.1,6038.2,0.9505961399117318,-0.0730955515908005,0.6368148209333377,0.19598683758404495,0.7520567985460924,0.12374935839288595,6189]
["O43149-3","Isoform 3 of Zinc finger ZZ-type and EF-hand domain-containing protein 1 [OS=Homo sapiens]",13,13,25,1,1085,119.9,5.67,74.37,"","","","ZZEF1","","","","",277.1,290.4,294.4,287.9,288.2,382.2,0.899405196702494,-0.15295687506182382,0.3696415940251794,0.4322191655924993,0.5684221356469674,0.2453290180032848,4753]
["O43150-1","Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 [OS=Homo sapiens]",4,3,4,3,1006,111.6,6.68,13.77,"other biological processes","plasma membrane;other membranes;ER/Golgi","enzyme regulator activity;other molecular function","ASAP2","ENSG00000151693","Endocytosis; Fc gamma R-mediated phagocytosis","","Vitamin D receptor pathway",117.2,101.6,111.2,96.9,128.8,152.6,0.8723235527359238,-0.19706475191619804,0.39122280495876804,0.40757583747572973,0.5817797520739849,0.23524139775991112,4915]
["O43156","TELO2-interacting protein 1 homolog [OS=Homo sapiens]",7,7,9,7,1089,122,5.97,19.69,"other biological processes","nucleus;other cell component","","TTI1","ENSG00000101407","mTOR signaling pathway","","Fragile X syndrome; Malignant pleural mesothelioma",1016.3,1007.5,1058.6,1082.4,997.3,1155.1,0.9528873500680102,-0.06962242545765637,0.351811251289439,0.453690275467582,0.5605817387561608,0.25136105371559164,4587]
["O43159","ribosomal rna-processing protein 8 [OS=Homo sapiens]",19,8,22,8,456,50.7,9.42,54.26,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","RRP8","ENSG00000132275","","SIRT1 negatively regulates rRNA expression","",1890.6,1871.3,1835.2,2255.8,2264.5,1651.7,0.9068535320803628,-0.14105853818521424,0.39963138223115324,0.39834041485378335,0.586291805043657,0.23188617617029808,4982]
["O43164","E3 ubiquitin-protein ligase Praja-2 [OS=Homo sapiens]",3,1,2,1,708,78.2,4.39,6.64,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component","other molecular function","PJA2","ENSG00000198961","","Antigen processing: Ubiquitination & Proteasome degradation","",45.5,39.1,45.7,84.8,77.9,81.1,0.5344544708777688,-0.9038610420520773,2.1162762044144628E-4,3.6744276512753795,0.023086362355321355,1.6366444920922332,67]
["O43166-1","Signal-induced proliferation-associated 1-like protein 1 [OS=Homo sapiens]",1,2,2,2,1804,199.9,8.19,0,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;enzyme regulator activity","SIPA1L1","ENSG00000197555","Rap1 signaling pathway","Neurexins and neuroligins","",90.4,88.3,94.8,92.2,93.8,278.1,0.5893126481361776,-0.7628948644902729,0.3615514833880063,0.44182985228553434,0.5647744800348233,0.24812493559374157,4679]
["O43169","Cytochrome b5 type B [OS=Homo sapiens]",55,5,29,5,146,16.3,4.97,98.99,"","other membranes","other molecular function","","","","","",2328,2609.8,3170.1,2621.4,2054.7,2395.4,1.1465601357562045,0.19731202459341182,0.3098135061608222,0.508899653319034,0.5357054451217056,0.2710739392640798,4227]
["O43172-1","U4/U6 small nuclear ribonucleoprotein Prp4 [OS=Homo sapiens]",43,19,56,1,522,58.4,7.42,166.66,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity","PRPF4","ENSG00000136875; ENSPTRG00000021274","Spliceosome","mRNA Splicing - Major Pathway","mRNA processing; mRNA Processing",153.4,156.5,155.8,171.4,201.6,210.2,0.7985253772290808,-0.32458983750660936,0.029418066832163258,1.531385869735915,0.18144865019095466,0.7412462581980649,1185]
["O43172-2","Isoform 2 of U4/U6 small nuclear ribonucleoprotein Prp4 [OS=Homo sapiens]",43,19,57,1,521,58.3,7.42,168.72,"","","","PRPF4","","","","",6857.9,6926.5,6912.5,7079.9,7108.6,7296.6,0.9633141107092823,-0.05392179622470193,0.020927909570505845,1.6792741499381645,0.15404037366649265,0.8123654365495727,993]
["O43175","D-3-phosphoglycerate dehydrogenase [OS=Homo sapiens]",43,18,195,18,533,56.6,6.71,658.6,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytosol","other molecular function","PHGDH","ENSG00000092621","Glycine, serine and threonine metabolism; Cysteine and methionine metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids","Serine biosynthesis","Trans-sulfuration and one-carbon metabolism; Clear cell renal cell carcinoma pathways; Neuroinflammation and glutamatergic signaling",14504.7,15352.2,14600.1,15590.3,16148.3,18313.5,0.8882144805113072,-0.1710200032135464,0.09940766474343704,1.002580128405039,0.322776819906611,0.49109766152158607,2251]
["O43181","NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [OS=Homo sapiens]",23,4,8,4,175,20.1,10.3,15.99,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity","NDUFS4","ENSG00000164258","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",1104.3,1122.1,1053.9,1026.4,1052,514.3,{"$f":"AVERAGE(S322:U322)/AVERAGE(V322:X322)","v":1.2652061557449763},{"$f":"LOG(Y322,2)","v":0.33937248028595385},{"$f":"TTEST(V322:X322,S322:U322,2,2)","v":0.263455949373344},0.5792919897241771,{"$f":"AA322*7309/AE322","v":0.49885998289372313},0.302021332511959,3860]
["O43182","Rho GTPase-activating protein 6 [OS=Homo sapiens]",7,6,7,6,974,105.9,7.36,16.39,"cell adhesion;cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","ARHGAP6","ENSG00000047648","","RHOA GTPase cycle; RAC3 GTPase cycle","",321.6,383,346,395,386,383.3,0.9023447565060552,-0.14824934935189032,0.10567444233401135,{"$f":"-LOG10(AA323)","v":0.9760300353551126},0.3316335332843663,{"$f":"-LOG10(AC323)","v":0.47934156200582023},2329]
["O43189-2","Isoform 1 of PHD finger protein 1 [OS=Homo sapiens]",18,5,10,5,457,49.6,7.93,27.84,"","","","PHF1","","","","",590.4,593.7,581.6,557.8,567.8,885,0.8781955635133791,-0.18738584864132513,0.4899140225084679,0.30988012982128627,0.6482225906072396,0.18827583784390697,5524]
["O43237","Cytoplasmic dynein 1 light intermediate chain 2 [OS=Homo sapiens]",18,7,14,7,492,54.1,6.38,47.14,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","DYNC1LI2","ENSG00000135720","Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection","Separation of Sister Chromatids; COPI-mediated anterograde transport; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Intraflagellar transport proteins binding to dynein",1228.6,1232.2,1238.5,1491.6,1411.1,1674.7,0.8081662078909426,-0.3072760659685381,0.019941062489721127,1.7002517055464386,0.15087911567015705,0.8213708700779591,966]
["O43242","26S proteasome non-ATPase regulatory subunit 3 [OS=Homo sapiens]",57,29,211,29,534,60.9,8.44,648.47,"protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","enzyme regulator activity","PSMD3","ENSG00000108344","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Interleukin-1 signaling; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease",19869.9,19888.1,20123,20029,19359.3,19592,1.0152712007229532,0.021865153692691906,0.23065587623978417,0.6370354767331285,0.4705173875067213,0.32742432301526625,3583]
["O43251-1","RNA binding protein fox-1 homolog 2 [OS=Homo sapiens]",2,1,1,1,390,41.3,7.27,2.16,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RBFOX2","ENSG00000100320; ENSG00000277564","","FGFR2 alternative splicing","Mammalian disorder of sexual development",49.9,48.8,52.1,70.1,58.5,752,0.17124687712923004,-2.5458504156682293,0.3484653311368445,0.457840423433759,0.5581707440892388,0.25323293032244687,4563]
["O43252","bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [OS=Homo sapiens]",52,24,106,22,624,70.8,6.86,321.71,"other metabolic processes;developmental processes","cytosol","kinase activity;other molecular function","PAPSS1","ENSG00000138801","Purine metabolism; Selenocompound metabolism; Sulfur metabolism; Metabolic pathways","Signaling by BRAF and RAF1 fusions; Transport and synthesis of PAPS; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se","Sulfation biotransformation reaction",11202.2,11337.6,11313.4,11694.8,11725.5,12200.6,0.9503746396076462,-0.07343175601345509,0.02517612307320901,1.599011147045706,0.16774137059442537,0.7753598127364443,1097]
["O43264","Centromere/kinetochore protein zw10 homolog [OS=Homo sapiens]",36,19,56,19,779,88.8,6.27,186.12,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","nucleic acid binding activity","ZW10","ENSG00000086827","","COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",3153.2,3211,3124.8,2982.9,3055.2,1988.2,1.1822383912886385,0.24152097566119612,0.23066978698612198,0.6370092854289933,0.4704144735160618,0.3275193245351079,3584]
["O43278","Kunitz-type protease inhibitor 1 [OS=Homo sapiens]",17,9,13,9,529,58.4,6.29,35.9,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes","enzyme regulator activity","SPINT1","ENSG00000166145","Transcriptional misregulation in cancer; Prostate cancer","MET Receptor Activation; Signaling by MST1","",1521.5,1504.3,1583.7,1451.6,1433.4,3188.7,0.7589278364094374,-0.39796538316466695,0.4493073913446123,0.3474564369739108,0.6170589483911633,0.20967334530530793,5322]
["O43283","Mitogen-activated protein kinase kinase kinase 13 [OS=Homo sapiens]",2,1,1,1,966,108.2,6.49,0,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;other cell component","kinase activity;other molecular function","MAP3K13","ENSG00000073803","MAPK signaling pathway","","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Insulin signaling",310.4,258.8,273.7,203.3,270.6,49.8,1.6095092610273056,0.6866208780269788,0.18806168804239162,0.7256996699811554,0.4307561510190662,0.36576851229069296,3191]
["O43290","U4/U6.U5 tri-snRNP-associated protein 1 [OS=Homo sapiens]",56,39,111,39,800,90.2,6.13,371.13,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","","SART1","ENSG00000175467","Spliceosome","mRNA Splicing - Major Pathway","",10868.4,10603.2,11091.4,11840.3,12343.4,13451.8,0.8652203371816504,-0.2088605183458105,0.02713720317690537,1.566434913766435,0.17460019191901527,0.7579552832574623,1136]
["O43291","Kunitz-type protease inhibitor 2 [OS=Homo sapiens]",13,3,3,3,252,28.2,8.29,4.49,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","enzyme regulator activity","SPINT2","ENSG00000167642","","MET Receptor Activation; Signaling by MST1","",442.7,435.8,429.2,385.9,378.6,1264.5,0.6445046821094135,-0.6337372555688677,0.45955134891026944,0.33766595478399253,0.6249043365925878,0.2041864614876625,5375]
["O43292-1","Glycosylphosphatidylinositol anchor attachment 1 protein [OS=Homo sapiens]",10,6,10,6,621,67.6,8.06,27.83,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi","cytoskeletal activity","GPAA1","ENSG00000197858","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways","Attachment of GPI anchor to uPAR","",1409,1458.9,1506.3,1107.1,1215.3,1366.1,1.1859021282364106,0.24598495007417767,0.04637247612821534,1.3337397136769922,0.22580708062699925,0.6462624440362895,1501]
["O43298","Zinc finger and BTB domain-containing protein 43 [OS=Homo sapiens]",2,1,1,1,467,52.6,5.76,2.49,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB43","ENSG00000169155","","","",66.2,64.3,56.3,37.7,57.2,0.6,1.9560209424083772,0.9679218167865511,0.14565317706296968,0.836680037875531,0.38198029104888603,0.4179590447048622,2787]
["O43299","AP-5 complex subunit zeta-1 [OS=Homo sapiens]",3,2,2,2,807,88.5,7.01,4.08,"DNA metabolism;stress response;transport","other membranes;nucleus;other cell component","","AP5Z1","ENSG00000242802","","","",92.4,96.9,99.5,143.6,110.1,1476.2,0.16694606624660385,-2.5825459953370595,0.34579497514223634,0.46118132188874356,0.5558424177071928,0.2550483142098788,4547]
["O43301","Heat shock 70 kDa protein 12A [OS=Homo sapiens]",2,1,4,1,675,74.9,6.77,0,"","nucleus;other cell component","other molecular function","HSPA12A","ENSG00000165868","","Regulation of HSF1-mediated heat shock response","",207.9,196.3,284.3,72.2,126.1,3.4,3.4134853743182942,1.771245570409365,0.022598091239648357,1.6459282422285488,0.15820828435880252,0.8007707790108193,1044]
["O43303","centriolar coiled-coil protein of 110 kDa [OS=Homo sapiens]",12,9,9,8,1012,113.4,8.65,21.8,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;other cell component","","CCP110","ENSG00000103540","","Ub-specific processing proteases; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; RHOV GTPase cycle","Genotoxicity pathway; Joubert syndrome",553.1,562.8,544.3,722.8,782.8,808.7,0.717365942185542,-0.47921884165545475,1.1054783011479417E-3,2.95644977753954,0.041864978772488626,1.3781491246633406,193]
["O43310","CBP80/20-dependent translation initiation factor [OS=Homo sapiens]",15,6,7,1,598,67.5,6.54,17.4,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity","CTIF","ENSG00000134030; ENSG00000282825","","","",371.3,395.7,389.1,489.9,442.7,1097.1,0.5695915652559491,-0.8120003124410449,0.2393659872824443,0.620937560633786,0.476320719043666,0.3221005270951068,3673]
["O43310-2","Isoform 2 of CBP80/20-dependent translation initiation factor [OS=Homo sapiens]",15,6,7,1,600,67.7,6.54,15.96,"","","","CTIF","","","","",24.3,25.4,26.1,38,23.5,210.6,0.27857405365674387,-1.8438672030785868,0.3374583985297998,0.47177975884053613,0.5512926765432067,0.25861777671717406,4474]
["O43314-1","inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 [OS=Homo sapiens]",15,16,30,13,1243,140.3,8.22,88.09,"other metabolic processes;other biological processes","cytosol","kinase activity;other molecular function","PPIP5K2","ENSG00000145725","Phosphatidylinositol signaling system","Synthesis of pyrophosphates in the cytosol","",2811.3,2921.1,2964.8,2710.5,2746.6,2651.8,1.0725499142917043,0.10104478938026167,0.02130513512010753,1.6715157070992468,0.154024958054269,0.8124089008062749,1011]
["O43318","mitogen-activated protein kinase kinase kinase 7 [OS=Homo sapiens]",3,2,2,2,606,67.2,7.11,3.79,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle","signal transduction activity or receptor binding;kinase activity;other molecular function","MAP3K7","ENSG00000135341","MAPK signaling pathway; NF-kappa B signaling pathway; Autophagy; AMPK signaling pathway; Wnt signaling pathway; Osteoclast differentiation; Adherens junction; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; IL-17 signaling pathway; T cell receptor signaling pathway; TNF signaling pathway; Alcoholic liver disease; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Leishmaniasis; Toxoplasmosis; Hepatitis B; Measles; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Ca2+ pathway; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; TNFR1-induced NFkappaB signaling pathway; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway","Regulation of toll-like receptor signaling pathway; IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; Fas ligand pathway and stress induction of heat shock proteins; Wnt signaling pathway; IL-6 signaling pathway; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Angiopoietin-like protein 8 regulatory pathway; Wnt signaling pathway and pluripotency; p38 MAPK signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; miRNAs involvement in the immune response in sepsis; Signal transduction through IL1R; Hepatitis B infection; IL-18 signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - interferon induction; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway",110.6,116.3,102.8,141.2,128.3,97.7,0.8978758169934641,-0.15541217174342062,0.4062454746740338,0.39121146376086524,0.5910127735653887,0.228403132606032,5024]
["O43324-1","Eukaryotic translation elongation factor 1 epsilon-1 [OS=Homo sapiens]",53,8,37,8,174,19.8,8.54,111.53,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","EEF1E1","ENSANAG00000036153; ENSG00000124802; ENSPTRG00000017709","","Selenoamino acid metabolism; Cytosolic tRNA aminoacylation","",4881.4,4496.4,4391.2,5300,5283.6,2630.4,1.0420009081277433,0.059356534958859564,0.847103859394925,0.07206333961391292,0.8954992924960237,0.04793475293632792,6914]
["O43353-1","Receptor-interacting serine/threonine-protein kinase 2 [OS=Homo sapiens]",10,4,5,4,540,61.2,7.09,10.76,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","RIPK2","ENSG00000104312","NOD-like receptor signaling pathway; Neurotrophin signaling pathway; Shigellosis; Salmonella infection; Tuberculosis","Downstream TCR signaling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; p75NTR recruits signalling complexes; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; activated TAK1 mediates p38 MAPK activation; Ovarian tumor domain proteases","Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Fas ligand pathway and stress induction of heat shock proteins; T-cell receptor (TCR) signaling pathway",220.7,230,244.5,260.4,227.8,276.2,0.9094714809000525,-0.13689969616305614,0.21912064546140414,0.6593167014554768,0.46048096540465866,0.33678831723819747,3478]
["O43379-4","Isoform 4 of WD repeat-containing protein 62 [OS=Homo sapiens]",7,10,16,10,1523,166.4,5.88,35.16,"","","","WDR62","","","","",1263.4,1284.4,1269.8,1240.3,1151.1,1239.4,1.0514487165363007,0.07237848563503776,0.10848240198443551,0.9646407073538821,0.335263372559932,0.47461389054373954,2365]
["O43390-1","heterogeneous nuclear ribonucleoprotein r [OS=Homo sapiens]",58,32,239,23,633,70.9,8.13,774.29,"RNA metabolism OR transcription;other metabolic processes;other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity","Hnrnpr; HNRNPR; LOC111154612","ENSAMEG00000009537; ENSCAFG00000013308; ENSCANG00000026442; ENSCATG00000035305; ENSFCAG00000019123; ENSG00000125944; ENSG00000282958; ENSGGOG00000013250; ENSLCNG00005013650; ENSMFAG00000039737; ENSMMUG00000010970; ENSMPUG00000015898; ENSNLEG00000008411; ENSRROG00000036942; ENSSSUG00005005658; ENSUAMG00000027050; ENSUMAG00000013292","","mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA","mRNA Processing; mRNA processing",25831.9,25943.1,25469,30181.9,28766.6,24215.1,0.9288198202098032,-0.10652933649385359,0.3359011422145898,0.4737885193597347,0.5503477804183897,0.2593627807173784,4461]
["O43395","U4/U6 small nuclear ribonucleoprotein Prp3 [OS=Homo sapiens]",42,24,72,24,683,77.5,9.5,192.25,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","other molecular function","PRPF3","ENSG00000117360","Spliceosome","mRNA Splicing - Major Pathway","mRNA processing",8391.2,7770.7,8212.2,9392.2,9415.7,8312.7,0.898730116590341,-0.15404014701423455,0.08817313220219426,1.0546637313528113,0.3041328094694846,0.5169367261796329,2119]
["O43396","Thioredoxin-like protein 1 [OS=Homo sapiens]",59,13,79,13,289,32.2,4.96,327.32,"","cytosol;nucleus;other cell component","other molecular function","TXNL1","ENSG00000091164","","RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle","",9236.9,9716.1,9375.9,8421.9,8617.9,6289.4,1.214310820773966,0.28013774794821045,0.09312813603420571,1.0309190893908324,0.3128095341332764,0.5047200185330017,2176]
["O43399","Tumor protein D54 [OS=Homo sapiens]",60,11,30,11,206,22.2,5.36,92.73,"other metabolic processes;other biological processes","other cell component","other molecular function","TPD52L2","ENSG00000101150","","","",2305.6,2436.3,2459.4,2426.5,2858.8,2903.4,0.8794191996287565,-0.1853770648307472,0.10792306368970156,0.9668857345310565,0.3345248823189265,0.47557157340615386,2358]
["O43402","ER membrane protein complex subunit 8 [OS=Homo sapiens]",29,5,10,5,210,23.8,6.4,41.53,"cell organization and biogenesis","other membranes;cytosol;ER/Golgi;other cell component","","EMC8","ENSG00000131148","","","",1189.8,1097.7,1118.4,1071.4,1102,659.6,1.2022237910342393,0.2657054752199966,0.25916490203027154,0.5864238140926512,0.49561388512277726,0.3048565349276723,3822]
["O43414-1","ERI1 exoribonuclease 3 [OS=Homo sapiens]",3,1,3,1,337,37.2,8.07,8.56,"RNA metabolism OR transcription;other metabolic processes","","nucleic acid binding activity;other molecular function","ERI3","ENSG00000117419; ENSMFAG00000044436; ENSMLEG00000012810; ENSMMUG00000011651; ENSMNEG00000035539; ENSNLEG00000014004; ENSPANG00000013867; ENSPPAG00000042776; ENSPTRG00000000655; ENSRBIG00000044795; ENSRROG00000036414","","","",608.6,647,628.5,629.2,593.6,494.2,1.0973209085614442,0.13398549974834295,0.25438305118681853,0.5945118278555725,0.491224761195365,0.3087197498076911,3785]
["O43422-1","52 kDa repressor of the inhibitor of the protein kinase [OS=Homo sapiens]",16,7,11,7,761,87.6,5.86,27.98,"other metabolic processes;signal transduction;other biological processes","","nucleic acid binding activity;kinase activity;other molecular function","THAP12","ENSG00000137492; ENSPTRG00000004091","","","",454.3,450.1,474.4,363.3,392,274.4,1.3390307856657282,0.42118913005483555,0.03240800822130756,1.48934765965204,0.18829104299645227,0.7251703388773171,1258]
["O43426","Synaptojanin-1 [OS=Homo sapiens]",7,9,12,9,1573,173,7.42,33.23,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity;other molecular function","SYNJ1","ENSG00000159082","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; Synthesis of IP3 and IP4 in the cytosol; Synthesis of IP2, IP, and Ins in the cytosol","VEGFA-VEGFR2 signaling pathway; EGF/EGFR signaling pathway",1025.4,982.8,1018.4,1013.9,1081.3,1042.3,0.9646533864541833,-0.051917440042160375,0.19189800162066287,0.716929547878587,0.4326287766333822,0.3638845965071101,3242]
["O43427","Acidic fibroblast growth factor intracellular-binding protein [OS=Homo sapiens]",23,9,17,9,364,41.9,6.48,41.38,"signal transduction","other membranes;mitochondrion;nucleus;other cell component","other molecular function","FIBP","ENSG00000172500","","","Modulators of TCR signaling and T cell activation",2219.4,2157.1,2162.7,2162.2,2092.2,1377.9,1.1610177014718677,0.2153899684403421,0.2954479877344445,0.5295189636088466,0.526048560865056,0.2789741631803332,4105]
["O43432","Eukaryotic translation initiation factor 4 gamma 3 [OS=Homo sapiens]",15,23,56,17,1585,176.5,5.38,136.67,"protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus","nucleic acid binding activity","EIF4G3","ENSG00000075151","Viral myocarditis","ISG15 antiviral mechanism","Translation factors; Translation inhibitors in chronically activated PDGFRA cells",2207.1,2235.2,2294.3,2511.6,2561.4,2319.5,0.9112749408183971,-0.13404169957386228,0.048835793700601815,1.3112617495446597,0.23208115484895883,0.634360123126099,1538]
["O43447","peptidyl-prolyl cis-trans isomerase H [OS=Homo sapiens]",47,8,66,7,177,19.2,8.07,156.88,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","PPIH","ENSG00000171960","Spliceosome","mRNA Splicing - Major Pathway","",6131.7,6001.9,5516,6010.3,6148.1,6364,0.9528786766293783,-0.06963555731825882,0.24519813521254888,0.6104828370491346,0.4820207558549004,0.3169342606010414,3718]
["O43463","Histone-lysine N-methyltransferase SUV39H1 [OS=Homo sapiens]",8,3,4,3,412,47.9,8.03,9.35,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SUV39H1","ENSG00000101945","Lysine degradation; Metabolic pathways","PKMTs methylate histone lysines; SIRT1 negatively regulates rRNA expression","Histone modifications; Retinoblastoma gene in cancer; Interactions between LOXL4 and oxidative stress pathway; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome",214.9,217.4,229.4,263.5,291.9,215.6,0.858236057068742,-0.2205535805856091,0.18391395851745393,0.7353853078633249,0.4278253096130079,0.36873352668330645,3142]
["O43464","Serine protease HTRA2, mitochondrial [OS=Homo sapiens]",30,9,36,9,458,48.8,10.07,113.17,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","HTRA2","ENSG00000115317","Apoptosis; Apoptosis; Parkinson disease; Pathways of neurodegeneration","","Parkinson's disease pathway; Nanomaterial induced apoptosis; Ciliary landscape; Complement system in neuronal development and plasticity",2034.5,2151.8,2099.4,1957.7,2058.9,1810.7,1.0786642184201947,0.10924583256244597,0.12747826947735627,0.8945638407233768,0.36127905064365917,0.44215722097734134,2579]
["O43488","aflatoxin B1 aldehyde reductase member 2 [OS=Homo sapiens]",39,11,37,11,359,39.6,7.17,96.56,"other metabolic processes","cytosol;ER/Golgi","other molecular function","AKR7A2","ENSG00000053371","Metabolism of xenobiotics by cytochrome P450","Aflatoxin activation and detoxification","Aflatoxin B1 metabolism; Metapathway biotransformation Phase I and II",5211.1,5318.9,5048.5,4891.3,5124.2,4580.6,1.0673056501394207,0.09397338777837325,0.13627466698346105,0.8655848705911992,0.37151493509217337,0.43002372269010575,2681]
["O43491-1","band 4.1-like protein 2 [OS=Homo sapiens]",48,43,149,40,1005,112.5,5.44,466.01,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","EPB41L2","ENSG00000079819","","Neurexins and neuroligins","Splicing factor NOVA regulated synaptic proteins",16266.5,16262.7,16144.4,15141.3,15325.6,14363.1,1.0857372295337944,0.11867498387942674,0.012604079732381554,1.899488858177837,0.12201750829665799,0.9135778479230523,755]
["O43493-1","Trans-Golgi network integral membrane protein 2 [OS=Homo sapiens]",37,16,34,2,480,51.1,5.73,98.24,"","","","","","","","",3837.4,3760.4,3586.8,5425.7,5494.7,3340.7,0.7842733029008984,-0.3505716037734047,0.22248785893099252,0.6526936833038989,0.4642203142810803,0.33327585873761834,3503]
["O43493-4","Isoform 4 of Trans-Golgi network integral membrane protein 2 [OS=Homo sapiens]",44,15,33,1,379,39.5,5.59,87.4,"","","","TGOLN2","","","","",514.2,496.7,446.6,741,712.3,783,0.6517461878996555,-0.6176178555068088,8.4341731622809835E-4,3.0739574867156185,0.03626198331947748,1.4405484462099194,170]
["O43502","DNA repair protein RAD51 homolog 3 [OS=Homo sapiens]",2,1,1,1,376,42.2,6.74,2.89,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","RAD51C","ENSG00000108384","Homologous recombination; Fanconi anemia pathway","Resolution of D-loop Structures through Holliday Junction Intermediates; Factors involved in megakaryocyte development and platelet production; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Meiotic recombination","DNA repair pathways, full network",25.4,25.6,18.7,32.7,29.1,33.7,0.7298429319371729,-0.45434207705468777,0.03199702799243662,1.4948903587559355,0.18724281633043977,0.727594835246098,1249]
["O43504","Ragulator complex protein LAMTOR5 [OS=Homo sapiens]",37,2,2,2,91,9.6,4.87,3.67,"cell organization and biogenesis;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","LAMTOR5","ENSG00000134248","mTOR signaling pathway","mTORC1-mediated signalling; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK","",51.7,58.5,49.5,67.9,78,54.8,0.7957149975087195,-0.32967630395138436,0.13217141724809897,0.8788624531223529,0.3674556442245551,0.4347950773447427,2629]
["O43513","Mediator of RNA polymerase II transcription subunit 7 [OS=Homo sapiens]",6,1,2,1,233,27.2,5.78,6.96,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","MED7","ENSG00000155868","","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Generic Transcription Pathway","",44.2,44.8,48.5,58,63,109.3,0.597047329570126,-0.7440827924934612,0.13208420372672972,0.8791491176202622,0.36735290907103024,0.43491651662403236,2628]
["O43521","Bcl-2-like protein 11 [OS=Homo sapiens]",15,2,2,2,198,22.2,8.21,4.69,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;other cell component","cytoskeletal activity;other molecular function","BCL2L11","ENSG00000153094","EGFR tyrosine kinase inhibitor resistance; FoxO signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Apoptosis; Non-alcoholic fatty liver disease; Epstein-Barr virus infection; Pathways in cancer; MicroRNAs in cancer; Colorectal cancer","NRAGE signals death through JNK; Signaling by BRAF and RAF1 fusions; Activation of BIM and translocation to mitochondria ; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; RUNX3 regulates BCL2L11 (BIM) transcription; FLT3 Signaling; FOXO-mediated transcription of cell death genes","Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Photodynamic therapy-induced unfolded protein response; BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Nonalcoholic fatty liver disease; EGFR tyrosine kinase inhibitor resistance; Host-pathogen interaction of human coronaviruses - apoptosis; Unfolded protein response; Galanin receptor pathway; ErbB signaling pathway; DNA damage response (only ATM dependent)",60.3,75.5,65.4,70.5,91,130.5,0.6890410958904111,-0.5373380639618522,0.17100503855752466,0.7669910932014593,0.4125002728768804,0.38457575981979136,3030]
["O43524","Forkhead box protein O3 [OS=Homo sapiens]",11,7,16,7,673,71.2,5.16,48.59,"RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","FOXO3","ENSG00000118689","EGFR tyrosine kinase inhibitor resistance; Chemokine signaling pathway; FoxO signaling pathway; Mitophagy; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Neurotrophin signaling pathway; Prolactin signaling pathway; Alcoholic liver disease; Shigellosis; Chemical carcinogenesis; Endometrial cancer; Non-small cell lung cancer","AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of localization of FOXO transcription factors; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; MAPK6/MAPK4 signaling; Signaling by NODAL; Interleukin-4 and Interleukin-13 signaling; FOXO-mediated transcription of cell cycle genes; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; RUNX3 regulates BCL2L11 (BIM) transcription; FLT3 Signaling; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation","IL-5 signaling pathway; Energy metabolism; Glioblastoma signaling pathways; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Kit receptor signaling pathway; Copper homeostasis; NAD metabolism, sirtuins and aging; Imatinib and chronic myeloid leukemia; Pathways affected in adenoid cystic carcinoma; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Non-small cell lung cancer; Overview of leukocyte-intrinsic Hippo pathway functions; Gastrin signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; DNA damage response (only ATM dependent)",1475.3,1502.7,1468.2,2468.2,2578.4,2778.4,0.5682044728434504,-0.815517906577673,2.4915708281621565E-4,3.603526762579711,0.024946426278133153,1.602991660816194,73]
["O43566","Regulator of G-protein signaling 14 [OS=Homo sapiens]",27,12,22,1,566,61.4,8.19,49.83,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","RGS14","ENSG00000169220","Rap1 signaling pathway","G alpha (i) signalling events","Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells",1508.7,1532.7,1559.3,1507.3,1661.7,2534.2,0.806687473698976,-0.3099182410536923,0.3148261487964457,0.5019292032304525,0.5386386520489751,0.26870248536697955,4272]
["O43566-5","Isoform 3 of Regulator of G-protein signaling 14 [OS=Homo sapiens]",36,12,24,1,414,44.8,9.2,56.83,"","","","RGS14","","","","",128.1,140,156.2,145.3,142.3,573.5,0.49274184183021713,-1.0210961096632933,0.3675660693876389,0.43466458585459156,0.5667806753489985,0.24658496564470367,4740]
["O43567","E3 ubiquitin-protein ligase RNF13 [OS=Homo sapiens]",8,2,5,2,381,42.8,4.98,13.39,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RNF13","ENSG00000082996","","","",990,839.1,916,954.4,1071.8,408.9,1.1273048334770646,0.1728776861222071,0.6466674156625325,0.18931902177203982,0.758179682559745,0.12022785782888787,6234]
["O43572","A-kinase anchor protein 10, mitochondrial [OS=Homo sapiens]",9,4,5,4,662,73.8,6.39,16.72,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;other cell component","other molecular function","AKAP10","ENSG00000108599","","Factors involved in megakaryocyte development and platelet production","G protein signaling pathways",200.4,202.6,191.3,251.1,230,339.8,0.7239615056645144,-0.46601510622991027,0.08925262059074905,1.0493790234914757,0.3062663868064717,0.5139006650462404,2130]
["O43583","density-regulated protein [OS=Homo sapiens]",22,5,11,5,198,22.1,5.3,35.13,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","","nucleic acid binding activity","DENR","ENSG00000139726","","","",982.9,980.4,863.8,1045.8,1092.6,855.3,0.9443498012492902,-0.08260674054393922,0.5378568385633301,0.26933330518062587,0.6786113642429449,0.16837887179571007,5793]
["O43592","Exportin-T [OS=Homo sapiens]",29,21,53,21,962,109.9,5.39,161.81,"transport","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","XPOT","ENSG00000184575","Nucleocytoplasmic transport","tRNA processing in the nucleus","",4125.3,4431.4,4763.4,4513.4,4113,6574.5,0.876270483984501,-0.19055183046031343,0.46897835439066293,0.32884720160395714,0.6328956411080789,0.19866789539707203,5416]
["O43598-1","2'-deoxynucleoside 5'-phosphate N-hydrolase 1 [OS=Homo sapiens]",68,8,60,8,174,19.1,5.05,166.11,"other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","C6orf108; DNPH1","ENSG00000112667","","Purine catabolism","",5433.2,4930.4,4838.9,5684.6,5691.1,6981.2,0.8281627072109123,-0.2720138563587964,0.08845011091409528,1.0533016181601444,0.3043699908997751,0.516598168685603,2124]
["O43615","Mitochondrial import inner membrane translocase subunit TIM44 [OS=Homo sapiens]",56,29,144,29,452,51.3,8.32,402.17,"cell organization and biogenesis;transport","other membranes;mitochondrion;nucleus","other molecular function","TIMM44","ENSG00000104980","","Mitochondrial protein import","",18185.4,18677.2,18364.1,17154.6,17212.4,17275.2,1.0694102884849988,0.09681546166484577,1.275033937261665E-3,2.8944782555678135,0.044166933874149335,1.354902748981533,211]
["O43617-1","Trafficking protein particle complex subunit 3 [OS=Homo sapiens]",47,9,26,9,180,20.3,4.96,60.57,"transport","other membranes;cytosol;ER/Golgi;other cell component","","TRAPPC3","ENSCANG00000028241; ENSCATG00000041647; ENSCSAG00000001096; ENSG00000054116; ENSGGOG00000004752; ENSMMUG00000022499; ENSMNEG00000014589; ENSPPAG00000041117; ENSPPYG00000001546; ENSRBIG00000043692; ENSRROG00000034420","","COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs","",5035.1,5035.3,4948.6,5092.8,5009.6,4117.2,1.0562181777265183,0.07890787580643638,0.44334329854485294,0.3532598518253564,0.6127829366611819,0.2126933364189673,5288]
["O43633","charged multivesicular body protein 2a [OS=Homo sapiens]",33,9,33,9,222,25.1,5.97,66.06,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle","other molecular function","CHMP2A","ENSG00000130724","Endocytosis; Necroptosis","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Lysosome Vesicle Biogenesis; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","",3387.8,3412.7,3410,3656.7,3612.8,3639.6,0.9359617200318999,-0.09547856876402512,1.0089250691018796E-4,3.9961410867699936,0.017557698404918186,1.755532415283921,42]
["O43639","Cytoplasmic protein NCK2 [OS=Homo sapiens]",22,8,11,7,380,42.9,6.95,32.89,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","NCK2","ENSG00000071051","ErbB signaling pathway; Axon guidance; T cell receptor signaling pathway; Pathogenic Escherichia coli infection","RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; Downstream signal transduction; VEGFA-VEGFR2 Pathway; Ephrin signaling; Activation of RAC1; Regulation of cortical dendrite branching","Pathogenic Escherichia coli infection; Brain-derived neurotrophic factor (BDNF) signaling pathway; EGF/EGFR signaling pathway; Genes controlling nephrogenesis; ErbB signaling pathway",955.4,937.2,926.5,1010.2,1007.6,874.6,0.9746577236896694,-0.03703242682590404,0.6201993285325249,0.2074687082934313,0.739846073485266,0.1308586267414123,6127]
["O43660-1","Pleiotropic regulator 1 [OS=Homo sapiens]",37,13,23,13,514,57.2,9.17,85.7,"RNA metabolism OR transcription;other metabolic processes;other biological processes","other membranes;nucleus;other cell component","","PLRG1","ENSG00000171566","Spliceosome","mRNA Splicing - Major Pathway","",2016.3,2114.9,2160.7,2478.4,2522.9,2725.3,0.8143167758134237,-0.296337971165983,0.005362531798382835,2.2706301195491765,0.08098087792227301,1.091617519309616,484]
["O43663-1","Protein regulator of cytokinesis 1 [OS=Homo sapiens]",25,12,17,12,620,71.6,6.68,47.23,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","PRC1","ENSG00000198901","","RHO GTPases activate CIT","",1163.6,1109.4,1215.6,1730.3,1321.3,1622.7,0.7463363498277815,-0.42210214152646525,0.03511397464782486,1.4545200087596752,0.19355055859800296,0.7132055709444567,1326]
["O43670-1","BUB3-interacting and GLEBS motif-containing protein ZNF207 [OS=Homo sapiens]",13,6,33,6,478,50.7,9.1,112.27,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","LOC111151255; Znf207; ZNF207","ENSAMEG00000005671; ENSANAG00000033773; ENSCANG00000036057; ENSCJAG00000014376; ENSECAG00000017464; ENSG00000010244; ENSGGOG00000024003; ENSMFAG00000001904; ENSMLEG00000018149; ENSMMUG00000016875; ENSMNEG00000041308; ENSNLEG00000005954; ENSOCUG00000008195; ENSPCOG00000020744; ENSPPAG00000032098; ENSPTRG00000008989; ENSRROG00000037743; ENSSBOG00000026038; ENSSTOG00000000712","","","",3610.8,3453.2,3367.8,3916.2,4030.8,4956,0.8084786483763465,-0.30671842173055996,0.07075260098011416,1.1502575901422154,0.27361415902838854,0.5628614324314867,1890]
["O43674-1","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [OS=Homo sapiens]",25,6,26,6,189,21.7,9.63,70.78,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB5","ENSG00000136521; ENSGGOG00000005222; ENSPTRG00000015649","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",3238.6,3110,3273.5,3228.6,3310.1,1843.9,1.1478658172881921,0.19895400434178134,0.4364268622101125,0.36008852629957594,0.6082845034122258,0.21589324743364965,5244]
["O43676","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [OS=Homo sapiens]",11,1,5,1,98,11.4,9.2,14.66,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity","NDUFB3","ENSG00000119013","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease",555.4,573.7,516.2,759.8,804.6,422.1,0.8282406242134407,-0.2718781279753781,0.4036824320566363,0.39396015033424164,0.58880760245499,0.23002659119274538,5011]
["O43678","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [OS=Homo sapiens]",29,2,3,2,99,10.9,9.57,10.45,"cell organization and biogenesis;other metabolic processes;transport;developmental processes","other membranes;mitochondrion","transporter activity","NDUFA2","ENSG00000131495","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",182.9,154.1,198.4,198.6,191.7,230.1,0.8629916183107673,-0.21258154739531293,0.18181308396086543,0.7403748665071167,0.42564760751760583,0.3709498033495425,3122]
["O43681","ATPase ASNA1 [OS=Homo sapiens]",50,11,55,11,348,38.8,4.91,159.62,"cell organization and biogenesis;transport","ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","GET3","ENSG00000198356","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",5756.5,6163.3,6185.1,5886.9,5263,4360.5,1.1672748607386014,0.22314431557290274,0.13609328949162183,0.8661632885263384,0.3712974441561269,0.4302780402505742,2679]
["O43683","Mitotic checkpoint serine/threonine-protein kinase BUB1 [OS=Homo sapiens]",14,13,24,13,1085,122.3,6.47,63.69,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","BUB1","ENSG00000169679","Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Cell cycle; ATM signaling in development and disease ; Regulation of sister chromatid separation at the metaphase-anaphase transition",1729.6,1699.5,1819.4,1320.6,1271.7,1747.3,{"$f":"AVERAGE(S386:U386)/AVERAGE(V386:X386)","v":1.2094432666605215},{"$f":"LOG(Y386,2)","v":0.27434309604193946},{"$f":"TTEST(V386:X386,S386:U386,2,2)","v":0.12279954504798199},0.9108032421811456,{"$f":"AA386*7309/AE386","v":0.3543394689126334},0.45058047008772056,2533]
["O43684","Mitotic checkpoint protein BUB3 [OS=Homo sapiens]",40,11,57,11,328,37.1,6.84,184.97,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","BUB3","ENSG00000154473","Cell cycle; Human T-cell leukemia virus 1 infection","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A","Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition",4106.1,4161.1,4150.2,4480.1,4289,4940.3,0.9057580929872935,-0.1428023036093266,0.0906415576489301,{"$f":"-LOG10(AA387)","v":1.042672639855576},0.3077097746660613,{"$f":"-LOG10(AC387)","v":0.5118587077950901},2153]
["O43707","Alpha-actinin-4 [OS=Homo sapiens]",72,59,636,38,911,104.8,5.44,2080.36,"transport;signal transduction;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function","ACTN4","ENSG00000130402; ENSG00000282844","Focal adhesion; Adherens junction; Tight junction; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Shigellosis; Amoebiasis; Viral carcinogenesis; Systemic lupus erythematosus","Platelet degranulation ; Nephrin family interactions","Arrhythmogenic right ventricular cardiomyopathy; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Striated muscle contraction pathway; Ebola virus pathway in host; Nephrotic syndrome",67503.3,68676.7,67881.1,64818.1,64268.4,78807.3,0.9815641447700701,-0.02684554465098881,0.8020665882075363,0.09578957474498248,0.8657959966340102,0.06258442665843397,6771]
["O43708","maleylacetoacetate isomerase [OS=Homo sapiens]",5,2,4,2,216,24.2,8.54,8.57,"other metabolic processes;other biological processes","cytosol;mitochondrion","other molecular function","GSTZ1","ENSG00000100577","Tyrosine metabolism; Metabolic pathways","Regulation of pyruvate dehydrogenase (PDH) complex; Glutathione conjugation; Tyrosine catabolism","Metapathway biotransformation Phase I and II",602.4,635.2,606.7,585.4,583,866.6,0.9062899262899262,-0.1419554460402593,0.5388240956939571,0.26855299128436066,0.67901126128054,0.16812302296332501,5800]
["O43709-1","Probable 18S rRNA (guanine-N(7))-methyltransferase [OS=Homo sapiens]",16,3,9,3,281,31.9,8.73,35.36,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","BUD23","ENSG00000071462; ENSGGOG00000001453","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","7q11.23 copy number variation syndrome",754.9,741.6,755.7,1116.2,1101.8,1123.9,0.6739280050270803,-0.5693336167416366,1.3574309317541782E-6,5.867282258771265,0.004960731340095645,2.304454292551273,2]
["O43719","HIV Tat-specific factor 1 [OS=Homo sapiens]",66,46,151,46,755,85.8,4.4,460.43,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","","HTATSF1","ENSG00000102241","","","",15805,15413.3,15720.4,14812.8,15296.4,16307.7,1.0112415951948537,0.016127711929819842,0.722395543597269,0.14122494181565368,0.8123060043311445,0.09028033657453625,6500]
["O43739","cytohesin-3 [OS=Homo sapiens]",18,6,17,2,400,46.3,5.47,57.64,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","CYTH3","ENSG00000008256","Phospholipase D signaling pathway; Endocytosis; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection","Intra-Golgi traffic","Insulin signaling",425.1,470.4,415.9,586.6,611.6,1137.7,0.5614110193073334,-0.8328707137158958,0.131397860672772,0.8814117055949102,0.3664200548101071,0.43602076465753764,2621]
["O43741","5'-AMP-activated protein kinase subunit beta-2 [OS=Homo sapiens]",4,1,1,1,272,30.3,6.46,2.61,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","PRKAB2","ENSG00000131791","FoxO signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Apelin signaling pathway; Tight junction; Circadian rhythm; Thermogenesis; Insulin signaling pathway; Adipocytokine signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Insulin resistance; Non-alcoholic fatty liver disease; Alcoholic liver disease; Hypertrophic cardiomyopathy","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Carnitine metabolism; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; AMPK inhibits chREBP transcriptional activation activity; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Lipophagy","AMP-activated protein kinase (AMPK) signaling; Target of rapamycin (TOR) signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Angiopoietin-like protein 8 regulatory pathway; Lipid metabolism pathway; Caloric restriction and aging; Genotoxicity pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; Malignant pleural mesothelioma",63.9,64.1,50.6,65.9,60.9,49.3,1.0141964792731402,0.020337171290014357,0.9062214179463686,0.04276567777148652,0.9375190861670216,0.028019882072090985,7065]
["O43747-1","AP-1 complex subunit gamma-1 [OS=Homo sapiens]",28,21,71,21,822,91.3,6.8,217.4,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","AP1G1","ENSCANG00000031796; ENSCCAG00000037984; ENSCJAG00000015028; ENSG00000166747; ENSGGOG00000004800; ENSMFAG00000037769; ENSMLEG00000040277; ENSMMUG00000010878; ENSMNEG00000034875; ENSPANG00000016832; ENSPPAG00000031149; ENSPTRG00000008327; ENSRBIG00000018408; ENSRROG00000025423; ENSSBOG00000025975","Lysosome; Human immunodeficiency virus 1 infection","MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression","",7106.1,7472.4,7752.2,7224.4,6492.4,4606,1.2187384024275767,0.285388490173156,0.17112132363957114,0.7666958691147746,0.4126445907230701,0.3844238435984239,3031]
["O43752","Syntaxin-6 [OS=Homo sapiens]",49,6,22,6,255,29.2,4.93,71.86,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","STX6","ENSG00000135823","SNARE interactions in vesicular transport","Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network","",1380.7,1405.5,1379.6,1251.7,1374.4,1315.7,1.0568268303820587,0.07973899884327451,0.1097166036480151,0.9597276447400882,0.3367990995646125,0.4726290782609951,2381]
["O43760","Synaptogyrin-2 [OS=Homo sapiens]",42,6,64,6,224,24.8,4.94,159.97,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","SYNGR2","ENSG00000108639","","","",4995.7,5494.8,5200.6,4717.2,4866.4,5040.2,1.0729837661893626,0.10162824886678226,0.10787769320473399,0.9670683488261737,0.33466810680534836,0.4753856730572647,2356]
["O43765","Small glutamine-rich tetratricopeptide repeat-containing protein alpha [OS=Homo sapiens]",39,11,76,11,313,34,4.87,190.79,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","SGTA","ENSG00000104969","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",9318.4,8666.5,8685.9,8752.8,9262,6439.7,1.0906295364861276,0.12516113224142142,0.4552471056550359,0.34175280665779245,0.6215955716855329,0.20649208815725104,5353]
["O43766-1","Lipoyl synthase, mitochondrial [OS=Homo sapiens]",4,2,2,2,372,41.9,8.59,4.94,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","mitochondrion","other molecular function","LIAS","ENSG00000121897","Lipoic acid metabolism; Metabolic pathways; Biosynthesis of cofactors","Glyoxylate metabolism and glycine degradation","",234.8,211.1,226.7,257.9,268.6,164.8,0.9729495154057572,-0.03956314678059704,0.8622053443340127,0.0643892895225183,0.9063510515946065,0.04270355702416108,6953]
["O43768","alpha-endosulfine [OS=Homo sapiens]",17,2,3,2,121,13.4,7.24,9.83,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","ENSA","ENSG00000143420","","MASTL Facilitates Mitotic Progression","",264.8,260.3,300.6,254.7,241.2,118.2,1.344569288389513,0.42714410213549736,0.19412567504626907,0.7119170210593415,0.4347011516278127,0.36180920925719207,3264]
["O43772","mitochondrial carnitine/acylcarnitine carrier protein [OS=Homo sapiens]",49,14,46,14,301,32.9,9.41,134.56,"transport;developmental processes","other membranes;cytosol;mitochondrion","transporter activity","SLC25A20","ENSG00000178537","Thermogenesis","Carnitine metabolism","Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation; Thermogenesis",7513.5,7678.4,7854.6,7116.8,6572.5,5849.2,1.1795429536556032,0.2382279560064526,0.037067248308052095,1.4310096526805771,0.19833420050040465,0.702602390142118,1366]
["O43776","Asparagine--tRNA ligase, cytoplasmic [OS=Homo sapiens]",44,27,177,26,548,62.9,6.25,523.97,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","NARS1","ENSG00000134440","Aminoacyl-tRNA biosynthesis","Cytosolic tRNA aminoacylation","Photodynamic therapy-induced unfolded protein response",20691.1,21623.3,20645.6,21624.7,21700,21522.9,0.9708917523547517,-0.04261764069140504,0.12298024646396584,0.910164640923562,0.35458091574166717,0.45028464270894375,2535]
["O43791","Speckle-type POZ protein [OS=Homo sapiens]",3,1,1,1,374,42.1,5.8,3.23,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","SPOP","ENSG00000121067","Hedgehog signaling pathway","Hedgehog 'on' state","mRNA processing; Hedgehog signaling pathway",50.7,45.9,53.5,101,83.8,49.2,0.6414529914529914,-0.6405845528500785,0.14339784517902707,0.8434573747064982,0.3790578120844516,0.4212945484632423,2765]
["O43795","Unconventional myosin-Ib [OS=Homo sapiens]",7,7,9,7,1136,131.9,9.38,22.07,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","MYO1B","ENSG00000128641","Pathogenic Escherichia coli infection","","",614.3,619.3,651.4,595,555.3,855.9,0.9395872794337555,-0.08990091327636054,0.6925140817942258,0.15957139109622367,0.7912436179199619,0.10168977992981337,6397]
["O43808","peroxisomal membrane protein PMP34 [OS=Homo sapiens]",8,3,6,3,307,34.5,10.08,14.39,"other metabolic processes;transport","other membranes;cytosol;other cytoplasmic organelle","transporter activity;other molecular function","SLC25A17","ENSG00000100372","Peroxisome","Class I peroxisomal membrane protein import; Alpha-oxidation of phytanate","",790.9,821.6,809.2,790.2,800.9,428.8,1.1989207386504281,0.2617362844937969,0.336070750381408,0.4735692843193685,0.5503789187850573,0.25933820927592505,4463]
["O43809","Cleavage and polyadenylation specificity factor subunit 5 [OS=Homo sapiens]",60,13,65,13,227,26.2,8.82,198.22,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","NUDT21","ENSG00000167005","mRNA surveillance pathway","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs","mRNA processing",8966.4,9283.2,8987.2,8855,9240.8,9662.8,0.9812022220140784,-0.0273775938851802,0.5322039648453308,0.27392189433924335,0.6752089531426008,0.17056180768179705,5761]
["O43813","LanC-like protein 1 [OS=Homo sapiens]",23,8,19,8,399,45.3,7.75,56.37,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","LANCL1","ENSG00000115365","Glutathione metabolism; Metabolic pathways","","",1629.8,1612.4,1676,1518.3,1540.6,1446.6,1.0915991565863943,0.12644318504065266,0.015711022501866203,1.8037955493669284,0.1355748092870603,0.8678209978136623,847]
["O43815","striatin [OS=Homo sapiens]",31,19,52,19,780,86.1,5.27,148.03,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","STRN","ENSG00000115808","","Extra-nuclear estrogen signaling; PIP3 activates AKT signaling; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins","",4947.8,4682.4,4798.5,5585.3,5696.3,6241.7,0.8234008434484373,-0.2803331684066419,0.008933247194423496,2.048990648358812,0.10582350687851107,0.9754178505080805,617]
["O43818","U3 small nucleolar RNA-interacting protein 2 [OS=Homo sapiens]",34,14,42,14,475,51.8,7.85,119.52,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","RRP9","ENSG00000114767","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",4887.8,5046,5144.1,5294.4,4605.5,7108.3,0.8865076845286389,-0.17379495797286432,0.439392626981145,0.3571472348262251,0.6098596108251403,0.2147701277123015,5266]
["O43819","Protein SCO2 homolog, mitochondrial [OS=Homo sapiens]",41,9,41,9,266,29.8,8.85,136.52,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","other membranes;cytoskeleton;mitochondrion","other molecular function","SCO2","ENSG00000284194","Central carbon metabolism in cancer","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","",2936.7,2867.8,2943.3,2897.6,2781.2,3879.4,0.9152141616622377,-0.12781871890544597,0.4822709524004458,0.31670889522533674,0.6426469263618703,0.1920275652520937,5485]
["O43823","A-kinase anchor protein 8 [OS=Homo sapiens]",30,12,37,12,692,76.1,5.15,125.45,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","mitochondrion;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","AKAP8","ENSG00000105127","","","G protein signaling pathways",3184.5,2914.8,3232.8,3875.2,4080.6,2723.5,0.8738494096054986,-0.1945434132554621,0.35900782858515135,0.4448960810198353,0.5644199223766124,0.24839766531894944,4649]
["O43824","Putative GTP-binding protein 6 [OS=Homo sapiens]",11,5,7,5,516,56.8,9.42,21.19,"","","","","","","","",672.4,671.7,674.2,715.5,642.9,1442.4,0.720615538417595,-0.4726983343850542,0.36463399896817106,0.43814283958706257,0.5662013805945108,0.24702907600968874,4707]
["O43826-1","Glucose-6-phosphate exchanger SLC37A4 [OS=Homo sapiens]",9,3,9,3,429,46.3,8.62,22.03,"other metabolic processes;transport;other biological processes","other membranes;ER/Golgi","transporter activity","SLC37A4","ENSG00000281500","Carbohydrate digestion and absorption","Gluconeogenesis; Glycogen storage disease type Ib (SLC37A4)","",879,891.9,895.3,777.8,803.8,690.5,1.1734518727168697,0.23075867320618199,0.019199679845300938,1.7167060130974092,0.14787192833435675,0.8301142636407289,949]
["O43829","Zinc finger and BTB domain-containing protein 14 [OS=Homo sapiens]",20,5,6,5,449,50.9,6.04,14.2,"developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB14","ENSG00000198081","","","",330.9,360,330.5,407,461.2,656,0.6701220312294974,-0.5775042563039826,0.09280150577796152,1.0324449769518902,0.3124303112533951,0.5052468385223372,2171]
["O43837-1","isocitrate dehydrogenase [NAD] subunit beta, mitochondrial [OS=Homo sapiens]",46,15,78,14,385,42.2,8.46,228.86,"other metabolic processes","mitochondrion","other molecular function","IDH3B","ENSG00000101365","Citrate cycle (TCA cycle); Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids","Citric acid cycle (TCA cycle)","TCA cycle (aka Krebs or citric acid cycle)",11711.6,11522.9,12212.4,10834.9,9659,8646,1.21643862882165,0.2826635359540177,0.034150805511504914,1.4665990482027718,0.1931952302504562,0.714003599977864,1292]
["O43847-1","Nardilysin [OS=Homo sapiens]",26,26,63,26,1150,131.5,5,183.22,"","","","","","","","",7053.7,7306.8,7540,7337.2,6665.7,5638.7,1.1150059058325188,0.15705135166371678,0.21640880082588798,0.6647250814933819,0.457942074474932,0.339189452840849,3454]
["O43852","Calumenin [OS=Homo sapiens]",71,22,218,6,315,37.1,4.64,726.76,"","non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","CALU","ENSG00000128595","","Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","NOTCH1 regulation of endothelial cell calcification; VEGFA-VEGFR2 signaling pathway",27238.5,24791.3,25139.7,26480.9,23816.2,18907.5,1.1150920603543695,0.1571628218353151,0.32100999617634834,0.49348144355576895,0.5417367956714223,0.2662116654016383,4331]
["O43852-4","Isoform 4 of Calumenin [OS=Homo sapiens]",59,17,159,1,323,38.1,4.58,498.58,"","","","CALU","","","","",444.2,344.7,413.6,353.2,365.9,218.7,1.282256344636383,0.35868470982394607,0.18727176835236908,0.7275276885772998,0.4305660128617382,0.3659602546080997,3179]
["O43861-1","Probable phospholipid-transporting ATPase IIB [OS=Homo sapiens]",9,8,12,8,1147,129.2,7.61,36.53,"cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ATP9B","ENSG00000166377","","Ion transport by P-type ATPases","",1385.4,1457.5,1344.6,1227,1412.9,1309.5,1.0602876386286524,0.08445569736404615,0.2768799612264045,0.5577084745314661,0.5100089809989392,0.2924221761296341,3968]
["O43865","S-adenosylhomocysteine hydrolase-like protein 1 [OS=Homo sapiens]",29,14,43,7,530,58.9,6.89,134.9,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","nucleic acid binding activity;other molecular function","AHCYL1","ENSG00000168710","Cysteine and methionine metabolism; Metabolic pathways","Role of phospholipids in phagocytosis; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Ion homeostasis; Regulation of insulin secretion; VEGFR2 mediated cell proliferation; PLC beta mediated events; DAG and IP3 signaling; CLEC7A (Dectin-1) induces NFAT activation","Trans-sulfuration and one-carbon metabolism; One-carbon metabolism and related pathways",3643.3,3601.9,3816,3186.4,2955.9,2999.9,1.209905711973048,0.2748946225667044,0.00267525472460602,2.572634860287977,0.059073827136390936,1.228604892179723,331]
["O43896","Kinesin-like protein KIF1C [OS=Homo sapiens]",9,10,10,4,1103,122.9,6.9,26.12,"transport;other biological processes","cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","KIF1C","ENSG00000129250","","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",289.7,304.5,275.7,279.9,332.3,632,0.6991641215238709,-0.516296941838999,0.3200427524867235,0.4947920031523406,0.540978833932808,0.2668197265496404,4324]
["O43903","Growth arrest-specific protein 2 [OS=Homo sapiens]",38,9,25,9,313,34.9,8.47,91.92,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton","cytoskeletal activity;other molecular function","GAS2","ENSG00000148935","","Caspase-mediated cleavage of cytoskeletal proteins","",3029.5,2737.1,2888.4,2971.8,3130.2,2280.9,1.0324589342590273,0.046084400028189164,0.7573005817564843,0.12073170955128328,0.8357405936974398,0.07792850271419847,6623]
["O43913","Origin recognition complex subunit 5 [OS=Homo sapiens]",19,9,17,9,435,50.3,7.74,48.42,"DNA metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ORC5","ENSG00000164815","Cell cycle","CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication","Cell cycle; G1 to S cell cycle control; DNA replication",2095.5,2071.5,2073.9,1984.5,2112.6,1643.4,1.087170107133525,0.12057769337107184,0.3000299229190557,0.5228354295784275,0.5285415055713131,0.2769209025234277,4149]
["O43920","NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [OS=Homo sapiens]",11,1,2,1,106,12.5,9.14,3.58,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity","NDUFS5","ENSG00000168653","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",59.9,55.5,53.4,60.2,62.7,76.1,0.848241206030151,-0.2374535267238257,0.13005654830719676,0.8858677763240441,0.36476719554002346,0.437984225816637,2606]
["O43924","Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [OS=Homo sapiens]",25,3,5,3,150,17.4,5.67,16.56,"other biological processes","other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","PDE6D","ENSG00000156973","Purine metabolism; Metabolic pathways","ARL13B-mediated ciliary trafficking of INPP5E; RAS processing","Phosphodiesterases in neuronal function; Joubert syndrome; Ciliopathies",565.9,536.2,542.3,564.2,523.5,529.5,1.0168191936680682,0.024063168292242615,0.5919728829714075,0.2276981869352117,0.7182486390501357,0.14372518824388292,6024]
["O43929","origin recognition complex subunit 4 [OS=Homo sapiens]",15,5,11,5,436,50.3,8,26.58,"DNA metabolism;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ORC4","ENSG00000115947","Cell cycle","CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication","Cell cycle; G1 to S cell cycle control; DNA replication",847.1,871.5,833.4,906,876.8,877.7,0.9592181920691598,-0.06006907441808854,0.06965296824185122,1.1570603715072192,0.2712272482044169,0.5666666822445925,1877]
["O43933","Peroxisome biogenesis factor 1 [OS=Homo sapiens]",8,11,16,11,1283,142.8,6.33,44.12,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","PEX1","ENSG00000127980","Peroxisome","Peroxisomal protein import","",1336.2,1299.6,1353.8,1321.8,1363.9,1689.4,0.9118877282804965,-0.13307188433908892,0.3346418522367752,0.47541974460844333,0.5496398422468741,0.2599217937054019,4450]
["O43934","UNC93-like protein MFSD11 [OS=Homo sapiens]",4,3,3,3,449,49.2,5.68,7.53,"","other membranes","","MFSD11","ENSG00000092931","","","",428.7,434.5,459.3,381,320.4,537,1.0679102067183461,0.09479034574433998,0.6893574878939309,0.16155550268374302,0.7888701861620074,0.10299445695775503,6387]
["O60216","Double-strand-break repair protein rad21 homolog [OS=Homo sapiens]",52,26,97,26,631,71.6,4.65,350.07,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","RAD21","ENSG00000164754","Cell cycle","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin","Cell cycle; Prion disease pathway; Regulation of sister chromatid separation at the metaphase-anaphase transition; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome",6773.1,6676.3,6853.5,8137,8262,7143.3,0.8624008699234995,-0.21356946151669612,0.039179325176847815,1.4069430485478973,0.20527719549647364,0.6876592942735407,1395]
["O60231","Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [OS=Homo sapiens]",23,21,45,21,1041,119.2,6.8,125.94,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","DHX16","ENSG00000204560; ENSG00000206486; ENSG00000226171; ENSG00000231377; ENSG00000233049; ENSG00000233418; ENSG00000233561","Spliceosome","mRNA Splicing - Major Pathway","mRNA processing",5702.2,5501.4,5873.5,6783.3,6634.3,6338.5,0.8643963130374922,-0.21023517629229058,0.006187020336467396,2.208518456470535,0.08849497385369902,1.0530813947212745,511]
["O60232","Sjoegren syndrome/scleroderma autoantigen 1 [OS=Homo sapiens]",27,3,5,3,199,21.5,5.24,24.01,"cell cycle OR cell proliferation;other biological processes","","","ZNRD2","ENSG00000173465","","","",347.1,322.6,316,469.7,479.7,702.2,0.5968152094938242,-0.7446437925688193,0.04400981527165851,1.3564504543561127,0.21926907963227812,0.6590226063154224,1467]
["O60234","glia maturation factor gamma [OS=Homo sapiens]",45,6,29,5,142,16.8,5.26,95.43,"protein metabolism;other metabolic processes;signal transduction;other biological processes","non-structural extracellular;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function","GMFG","ENSG00000130755","","Neutrophil degranulation","",2579.5,2323.1,2263.2,2702.7,2764.4,2701.4,0.8772479647426087,-0.18894339937779048,0.028067353414346182,1.5517985368395308,0.17807663724431966,0.749393054042751,1152]
["O60237","Protein phosphatase 1 regulatory subunit 12b [OS=Homo sapiens]",13,11,12,10,982,110.3,5.67,29.37,"signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP1R12B","ENSG00000077157","Vascular smooth muscle contraction; Focal adhesion; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Proteoglycans in cancer","RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs","Focal adhesion",606.8,566,637.2,706.3,721.5,854.8,0.7929554017348638,-0.33468836830905235,0.03766350406323301,1.424079277401318,0.19991470675248368,0.6991552557742687,1377]
["O60244","Mediator of RNA polymerase II transcription subunit 14 [OS=Homo sapiens]",6,7,13,6,1454,160.5,8.73,34.12,"other biological processes","nucleus","other molecular function","MED14","ENSG00000180182","Thyroid hormone signaling pathway","Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","Vitamin D in inflammatory diseases",832.6,783.3,791.1,763.9,785.9,1622.8,0.7586837294332724,-0.3984294965582693,0.41834863704641123,0.378461641580114,0.5965099859875574,0.22438228154436632,5126]
["O60256-1","Phosphoribosyl pyrophosphate synthase-associated protein 2 [OS=Homo sapiens]",34,10,27,9,369,40.9,7.44,112.72,"other metabolic processes;other biological processes","other cell component","enzyme regulator activity;other molecular function","PRPSAP2","ENSG00000141127","","","",2738,2755.7,2813.8,2837.7,2664.5,2649.7,1.0190875746758425,0.027278033958841204,0.466699329856582,0.3309628227270092,0.6306351269960728,0.20022184228510065,5409]
["O60264","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 [OS=Homo sapiens]",39,40,133,40,1052,121.8,8.09,366.57,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMARCA5","ENSG00000153147","","Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; NoRC negatively regulates rRNA expression","",13827.1,13793.7,13994.8,15770,16147.3,21682.8,0.7764089992369418,-0.3651112546832037,0.10492985039755061,0.9791009463270621,0.33057425713607647,0.48073096933398884,2320]
["O60266","Adenylate cyclase type 3 [OS=Homo sapiens]",4,4,8,4,1144,128.9,6.58,20.91,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","ADCY3","ENSG00000138031","Purine metabolism; Metabolic pathways; Endocrine resistance; Rap1 signaling pathway; Calcium signaling pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Phospholipase D signaling pathway; Oocyte meiosis; Longevity regulating pathway; Longevity regulating pathway; Adrenergic signaling in cardiomyocytes; Vascular smooth muscle contraction; Apelin signaling pathway; Gap junction; Platelet activation; Circadian entrainment; Thermogenesis; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; GABAergic synapse; Olfactory transduction; Inflammatory mediator regulation of TRP channels; Insulin secretion; GnRH signaling pathway; Ovarian steroidogenesis; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Melanogenesis; Thyroid hormone synthesis; Oxytocin signaling pathway; Regulation of lipolysis in adipocytes; Aldosterone synthesis and secretion; Relaxin signaling pathway; Cortisol synthesis and secretion; Parathyroid hormone synthesis, secretion and action; Cushing syndrome; Growth hormone synthesis, secretion and action; Vasopressin-regulated water reabsorption; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Bile secretion; Morphine addiction; Vibrio cholerae infection; Human cytomegalovirus infection; Human T-cell leukemia virus 1 infection; Pathways in cancer; Chemical carcinogenesis; Dilated cardiomyopathy","FCGR3A-mediated IL10 synthesis; Olfactory Signaling Pathway; G alpha (i) signalling events; G alpha (z) signalling events; Adenylate cyclase inhibitory pathway; ADORA2B mediated anti-inflammatory cytokines production; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Adenylate cyclase activating pathway; Hedgehog 'off' state","Thyroid stimulating hormone (TSH) signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; Phosphodiesterases in neuronal function; Thermogenesis; Envelope proteins and their potential roles in EDMD physiopathology; Neuroinflammation and glutamatergic signaling; Calcium regulation in cardiac cells",319.8,342.3,327.5,265.4,307.7,350.7,1.0712275384282313,0.099264954127333,0.4381157501676075,0.3584111337473497,0.6090125557198637,0.21537375363372066,5258]
["O60268-1","Uncharacterized protein KIAA0513 [OS=Homo sapiens]",9,3,3,3,411,46.6,5.06,9.16,"","other cell component","","KIAA0513","ENSG00000135709","","","",317.4,332.8,308.1,319.6,341.4,249,1.0530769230769232,0.07461082334208294,0.6059738952115851,0.21754608443066692,0.728224794492186,0.13773453835480728,6082]
["O60271","C-jun-amino-terminal kinase-interacting protein 4 [OS=Homo sapiens]",33,37,102,2,1321,146.1,5.15,305,"transport;other biological processes","other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","SPAG9","ENSG00000008294","","Myogenesis","",10277.6,9797.2,10079.9,10545.3,10468.9,9689.2,0.9821290150276518,-0.02601554171721028,0.5834034278069671,0.2340310234945785,0.7128210721900906,0.14701947030590493,5982]
["O60271-2","Isoform 2 of C-Jun-amino-terminal kinase-interacting protein 4 [OS=Homo sapiens]",32,36,103,1,1311,145,5.19,309.2,"","","","SPAG9","","","","",336.5,353.1,347.5,387.6,387.5,124.8,1.1524613845982887,0.20471841123432777,0.6296488250003258,0.20090160274862764,0.7468522008970109,0.12676533484557656,6162]
["O60281-1","zinc finger protein 292 [OS=Homo sapiens]",2,5,5,5,2723,304.6,7.39,7.84,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF292","ENSG00000188994","","","",81.2,73.2,91.3,107.8,100.7,461,0.3669902912621359,-1.446186197849508,0.30103792544689645,0.5213787875465156,0.529296655542787,0.2763008501687575,4157]
["O60285","NUAK family SNF1-like kinase 1 [OS=Homo sapiens]",2,1,1,1,661,74.3,8.82,2.03,"cell adhesion;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","NUAK1","ENSG00000074590","","Regulation of TP53 Activity through Phosphorylation","",57.9,61.6,69.8,82.8,80.8,156,0.5923028785982477,-0.7555929972242719,0.15718308554714022,0.8035941901590183,0.39492993202614224,0.4034799495221046,2909]
["O60287","nucleolar pre-ribosomal-associated protein 1 [OS=Homo sapiens]",8,14,26,14,2271,254.2,6.47,81.68,"RNA metabolism OR transcription;other metabolic processes","nucleus","","URB1","ENSG00000142207","","","",2758.7,3011,2969.7,3446.5,3317.7,10983.1,0.49243546905726504,-1.0219934151321979,0.3018211977018871,0.5202502618378692,0.5299089920737672,0.27579871084067353,4163]
["O60291-1","E3 ubiquitin-protein ligase MGRN1 [OS=Homo sapiens]",6,2,2,2,552,60.7,5.15,7.27,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MGRN1","ENSG00000102858","Ubiquitin mediated proteolysis; Hedgehog signaling pathway","Antigen processing: Ubiquitination & Proteasome degradation","",103.6,112.5,142.6,130,115.8,163.8,0.875732421875,-0.19143797004247548,0.41075919777723,0.38641270300142594,0.5934451426277474,0.22661942052602035,5059]
["O60292","Signal-induced proliferation-associated 1-like protein 3 [OS=Homo sapiens]",1,1,1,1,1781,194.5,8.32,2.87,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","enzyme regulator activity","SIPA1L3","ENSG00000105738","Rap1 signaling pathway","","",29,16.3,25,21.3,21.1,16.5,1.193548387096774,0.25525705524207437,0.4026531535420618,0.39506889520423083,0.588245432588233,0.230441436203667,5003]
["O60293","Zinc finger C3H1 domain-containing protein [OS=Homo sapiens]",8,11,13,11,1989,226.2,8.13,35.99,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","other molecular function","ZFC3H1","ENSG00000133858","","","",592.6,624,582.7,830.6,884.6,868.4,0.6964313361201425,-0.5219469759764193,2.0847598165178998E-4,3.6809439725220923,0.023087135604438376,1.6366299461799878,66]
["O60294","tRNA wybutosine-synthesizing protein 4 [OS=Homo sapiens]",5,3,3,3,686,75.6,6.73,3.98,"RNA metabolism OR transcription;other metabolic processes","other cell component","other molecular function","LCMT2","ENSG00000168806","","Synthesis of wybutosine at G37 of tRNA(Phe)","",334.8,362.9,365.2,354.7,347.9,191.8,1.1883944543828269,0.24901377799628,0.3577563761951252,0.4464126171861277,0.5640296276122023,0.24869808259371307,4636]
["O60306","Intron-binding protein aquarius [OS=Homo sapiens]",14,20,39,19,1485,171.2,6.37,107.07,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","AQR","ENSG00000021776","Spliceosome","mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER","",3697,3681,3902.8,4478,4610.9,4476.3,0.8315985020493615,-0.26604093540188284,8.2799512662710126E-4,3.0819722193566497,0.03645672518384026,1.4382223455127319,166]
["O60307","Microtubule-associated serine/threonine-protein kinase 3 [OS=Homo sapiens]",3,4,6,2,1309,143,8.06,12.05,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction","","kinase activity;other molecular function","MAST3","ENSG00000099308","","","",145.5,144,149.4,205.7,198.1,274.2,0.6473451327433628,-0.6273930031640632,0.030324192941438198,1.5182107487711702,0.1837807016658141,0.7357000946913297,1206]
["O60308","Centrosomal protein of 104 kDa [OS=Homo sapiens]",2,2,3,2,925,104.4,7.62,7.45,"","cytoskeleton;other cell component","other molecular function","CEP104","ENSG00000116198","","","Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies",283.3,241.9,320.6,293,235.7,337.8,0.9761107905366417,-0.03488318901873021,0.8621601789885034,0.06441203998936207,0.906433939618379,0.04266384154599918,6952]
["O60313-2","Isoform 2 of Dynamin-like 120 kDa protein, mitochondrial [OS=Homo sapiens]",41,39,101,39,997,115.8,7.87,303.65,"","","","OPA1","","","","",12456.5,12591.9,12822.1,12934.5,12496.6,10329.4,{"$f":"AVERAGE(S450:U450)/AVERAGE(V450:X450)","v":1.0590036492778345},{"$f":"LOG(Y450,2)","v":0.0827075607995257},{"$f":"TTEST(V450:X450,S450:U450,2,2)","v":0.4354693868272701},0.3610423701610209,{"$f":"AA450*7309/AE450","v":0.6079934571767941},0.2161010942919091,5235]
["O60318","Germinal-center associated nuclear protein [OS=Homo sapiens]",12,13,21,13,1980,218.3,6.39,81.22,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","MCM3AP","ENSG00000160294","","","",1214.7,1240,1264.9,1281.1,1266.5,1720,0.8715905895585339,-0.19827747492565675,0.28883673433928186,{"$f":"-LOG10(AA451)","v":0.5393475738921604},0.5208753247682731,{"$f":"-LOG10(AC451)","v":0.2832662157498805},4053]
["O60331","Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [OS=Homo sapiens]",9,6,10,5,668,73.2,5.29,22.5,"cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","PIP5K1C","ENSG00000186111","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Phospholipase D signaling pathway; Endocytosis; Focal adhesion; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Yersinia infection; Choline metabolism in cancer","Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion","B cell receptor signaling pathway; Focal adhesion; Regulation of actin cytoskeleton",964.5,984.8,1018.6,882.3,877.3,1325.8,0.9619174175147471,-0.056015053756962425,0.8062824548726374,0.09351279057259562,0.868935190602198,0.06101261413069013,6782]
["O60333","Kinesin-like protein KIF1B [OS=Homo sapiens]",15,21,28,9,1816,204.3,5.6,85.55,"cell-cell signaling;transport;other biological processes","other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","KIF1B","ENSG00000054523","","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","Intracellular trafficking proteins involved in CMT neuropathy",2040.5,2193.2,2217.2,2461.7,2460.7,3108.3,0.8032799133325861,-0.31602529368425863,0.07725949502050616,1.112048134794931,0.28664449193141095,0.5426563990725508,1970]
["O60333-3","Isoform 3 of Kinesin-like protein KIF1B [OS=Homo sapiens]",13,13,18,1,1153,130.3,8.43,47.74,"","","","KIF1B","","","","",47.8,32.9,42.5,47,43.7,28.9,1.0301003344481605,0.0427848664967963,0.8734648324835896,0.0587545759309389,0.9142423686986334,0.038938656087982436,6983]
["O60337","E3 ubiquitin-protein ligase MARCH6 [OS=Homo sapiens]",2,2,2,2,910,102.5,6.28,5.33,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","other molecular function","MARCHF6","ENSG00000145495","Protein processing in endoplasmic reticulum","ER Quality Control Compartment (ERQC)","",207.7,211.7,209.4,282.2,288.9,535.9,0.5680216802168021,-0.8159820994103083,0.12883067116048752,0.8899807306872255,0.36258119965806823,0.4405947184325552,2597]
["O60341","Lysine-specific histone demethylase 1A [OS=Homo sapiens]",20,13,20,13,852,92.8,6.52,66.77,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KDM1A","ENSG00000004487","Thermogenesis","Estrogen-dependent gene expression; Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; Factors involved in megakaryocyte development and platelet production; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3","Androgen receptor signaling pathway; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; Thermogenesis; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects",1802,1778.6,1845.8,2261.8,2179,2059,0.8348564571217576,-0.2603999289182671,4.496178304227199E-3,2.347156474350359,0.07537286060916651,1.1227850017349723,436]
["O60343-1","TBC1 domain family member 4 [OS=Homo sapiens]",1,1,1,1,1298,146.5,7.01,0,"transport;other biological processes","cytosol;other cell component","enzyme regulator activity","TBC1D4","ENSG00000136111","Thyroid hormone signaling pathway; Insulin resistance; Diabetic cardiomyopathy","Translocation of SLC2A4 (GLUT4) to the plasma membrane","Ciliary landscape; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling",36.5,27.3,37.5,23.3,23.9,18.5,1.541856925418569,0.6246688984788084,0.031831567912687084,1.4971419690114958,0.1874753665381385,0.7270557886262526,1241]
["O60344-1","Endothelin-converting enzyme 2 [OS=Homo sapiens]",5,4,10,4,883,99.7,5.1,26.93,"protein metabolism;other metabolic processes;developmental processes","plasma membrane;other membranes;ER/Golgi","other molecular function","EEF1AKMT4-ECE2","ENSG00000284917","","","",1223.7,1261.3,1265.1,1393.1,1286.6,2842.5,0.6790952881098112,-0.5583140726437572,0.3045599510969434,0.5163272059281564,0.5320336239406213,0.27406091990340126,4184]
["O60353-1","Frizzled-6 [OS=Homo sapiens]",6,3,3,3,706,79.2,7.96,6.58,"cell-cell signaling;cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","FZD6","ENSG00000164930","mTOR signaling pathway; Wnt signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Proteoglycans in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer","Class B/2 (Secretin family receptors); Ca2+ pathway; PCP/CE pathway; Regulation of FZD by ubiquitination; Signaling by RNF43 mutants","Alzheimer's disease and miRNA effects; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Osteoblast differentiation and related diseases; Malignant pleural mesothelioma; Alzheimer's disease",95.5,99.4,97.4,115.1,126.5,246.4,0.5989754098360657,-0.7394313186441956,0.19543418010803765,0.708999478825238,0.4358951548396848,0.36061795832364085,3277]
["O60361","putative nucleoside diphosphate kinase [OS=Homo sapiens]",66,8,139,1,137,15.5,8.57,432.69,"other metabolic processes;other biological processes","","kinase activity;other molecular function","NME2P1","","","Interconversion of nucleotide di- and triphosphates","",988.3,613.4,854.6,692.4,652.8,165.6,1.6258273762245168,0.701174086019598,0.19337718889683975,0.7135947573497773,0.43408902753286294,0.3624211916829679,3256]
["O60381-1","HMG box-containing protein 1 [OS=Homo sapiens]",5,2,2,2,514,57.6,6.19,7.78,"cell-cell signaling;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HBP1","ENSG00000105856; ENSG00000283847; ENSPPAG00000042116; ENSPTRG00000019575","","","",161.3,172.8,167.5,154.4,152.8,222,0.9478458049886622,-0.07727571347663768,0.7101347576962737,0.1486592301955395,0.8035880080511014,0.09496655285471617,6459]
["O60427","Fatty acid desaturase 1 [OS=Homo sapiens]",2,1,1,1,444,51.9,8.87,2.12,"cell-cell signaling;other metabolic processes;stress response;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","FADS1","ENSG00000149485","Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism","PPARA activates gene expression; alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Linoleic acid metabolism affected by coronavirus infection",269.2,261.1,247.9,367,389,419.4,0.6620724859622256,-0.5949389180158876,1.2819253105549758E-3,2.892137277593149,0.044196189126633575,1.3546151766379273,212]
["O60447","Ecotropic viral integration site 5 protein homolog [OS=Homo sapiens]",3,2,2,2,810,92.9,6.1,6.74,"cell cycle OR cell proliferation;transport;other biological processes","cytosol;cytoskeleton;nucleus","enzyme regulator activity;other molecular function","EVI5","ENSG00000067208","","","",76.7,81.1,86,96.1,89.2,93.6,0.8741484403011833,-0.19404980840809988,0.02527652924319856,1.5972825598995033,0.16764623615112367,0.7756061925312965,1102]
["O60449","Lymphocyte antigen 75 [OS=Homo sapiens]",7,11,15,11,1722,198.2,6.67,42.58,"stress response;transport;other biological processes","plasma membrane;other membranes","other molecular function","LY75","ENSG00000054219","","","",1619.9,1573,1534.5,1687.8,1741.2,1922.4,0.883394999439399,-0.1788694290300109,0.050474086887852654,1.2969315290094634,0.23587922062871805,0.6273103158493196,1564]
["O60476","mannosyl-oligosaccharide 1,2-alpha-mannosidase IB [OS=Homo sapiens]",7,4,10,4,641,73,7.61,26.26,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","MAN1A2","ENSG00000198162","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum","Intra-Golgi traffic; Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2","",753.3,764.2,794.5,758.6,743.5,1118.5,0.8822407082347554,-0.18075576427650394,0.45063812326180736,0.3461720704420165,0.617957606551698,0.20904131758461575,5330]
["O60486","Plexin-C1 [OS=Homo sapiens]",24,30,84,29,1568,175.6,7.61,247.2,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","PLXNC1","ENSG00000136040","Axon guidance","Other semaphorin interactions","",8643.8,8985.8,8919.5,7173.7,7596.6,6837.2,1.228698368622006,0.2971307940649333,2.4862492548535656E-3,2.604455334028607,0.057324907898185215,1.2416566343623858,317]
["O60488-1","Long-chain-fatty-acid--CoA ligase 4 [OS=Homo sapiens]",42,23,70,20,711,79.1,8.38,174.26,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ACSL4","ENSG00000068366","Fatty acid biosynthesis; Fatty acid degradation; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; Peroxisome; Ferroptosis; Thermogenesis; Adipocytokine signaling pathway","Synthesis of very long-chain fatty acyl-CoAs; Intracellular metabolism of fatty acids regulates insulin secretion","Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters",8773.3,8581,9025,8245.1,8046.9,7127.4,1.126386670879698,0.17170216702682403,0.054973531146136526,1.2598463658534818,0.2445535843865562,0.6116259674045704,1643]
["O60493-1","sorting nexin-3 [OS=Homo sapiens]",15,2,3,2,162,18.8,8.66,9.39,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","LOC111158258; Snx3; SNX3; Snx3_1","ENSAMEG00000008145; ENSANAG00000028701; ENSBIXG00000016466; ENSBIXG00005007963; ENSBMUG00000010256; ENSBTAG00000018801; ENSCANG00000036155; ENSCATG00000029122; ENSCCAG00000022069; ENSCGRG00015001325; ENSCHIG00000003391; ENSCJAG00000005955; ENSCSAG00000015156; ENSDLEG00000017815; ENSFCAG00000024997; ENSG00000112335; ENSLCNG00005012116; ENSMFAG00000039300; ENSMMNG00015010894; ENSMMUG00000020366; ENSMNEG00000027766; ENSMPUG00000009812; ENSMUSG00000019804; ENSNVIG00000004406; ENSOARG00000010805; ENSPANG00000017995; ENSPCOG00000020531; ENSPCTG00005013214; ENSPPAG00000032382; ENSPPYG00000016894; ENSPTRG00000018473; ENSPTRG00000046352; ENSRFEG00010011106; ENSRROG00000037899; ENSSBOG00000028606; ENSSSCG00000004385; ENSSSCG00070023370; ENSSSUG00005019212; ENSSTOG00000007274; ENSTSYG00000035289; ENSTTRG00000008868; ENSUAMG00000027552","Endocytosis","Ub-specific processing proteases; WNT ligand biogenesis and trafficking; Ub-specific processing proteases; WNT ligand biogenesis and trafficking; WNT ligand biogenesis and trafficking; Ub-specific processing proteases; WNT ligand biogenesis and trafficking","",301.6,333.4,281.1,470.7,471.2,662.4,0.5710278626192109,-0.8083669530087764,0.02497159234673142,1.602553763401574,0.16683488890517362,0.777713123515013,1094]
["O60496","Docking protein 2 [OS=Homo sapiens]",43,11,20,11,412,45.4,6.02,62.11,"signal transduction","cytosol","signal transduction activity or receptor binding","DOK2","ENSG00000147443","","RET signaling; Tie2 Signaling","RAC1/PAK1/p38/MMP2 pathway; IL-4 signaling pathway; EGF/EGFR signaling pathway",1697.7,1612,1665.6,1788.8,1798.2,2269.3,0.8495637177057185,-0.23520594056703434,0.14142806707062364,0.8494643941862517,0.3773996868270128,0.4231984645562402,2739]
["O60499","Syntaxin-10 [OS=Homo sapiens]",19,2,3,2,249,28.1,4.89,9.32,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","STX10","ENSG00000104915","Salmonella infection","Retrograde transport at the Trans-Golgi-Network","",23.7,21.1,23.4,21.3,24.2,23.3,0.9912790697674417,-0.012636825677925657,0.8743693531514003,0.05830507291389672,0.9145342876622188,0.03880000734081709,6988]
["O60502","protein O-GlcNAcase [OS=Homo sapiens]",33,27,59,27,916,102.8,4.91,160.99,"protein metabolism;other metabolic processes","cytosol;nucleus","other molecular function","OGA","ENSG00000198408","Insulin resistance","","",6395.2,6409.6,6308.9,8554.2,8713.5,6651.8,0.7990844290223457,-0.323580152564131,0.07307163604631518,1.136251168856609,0.2774444612272819,0.5568239408171556,1925]
["O60506","Heterogeneous nuclear ribonucleoprotein Q [OS=Homo sapiens]",58,32,270,2,623,69.6,8.59,831.37,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity","SYNCRIP","ENSG00000135316","","","",15699.2,16001.6,15385.8,18221.6,17923,15128.9,0.9183418335007363,-0.12289682828486306,0.2356336871253879,0.6277626209866913,0.4739258720967144,0.32428958207473385,3634]
["O60506-3","Isoform 3 of Heterogeneous nuclear ribonucleoprotein Q [OS=Homo sapiens]",56,29,255,1,562,62.6,7.56,769.42,"","","","SYNCRIP","","","","",403.1,394.6,387.2,565.7,581.9,1295,0.4850978465569476,-1.043652319742404,0.1562432709454449,0.8061986776907114,0.39419470740084805,0.40428921101050025,2897]
["O60508","pre-mRNA-processing factor 17 [OS=Homo sapiens]",21,10,17,10,579,65.5,7.06,44.75,"RNA metabolism OR transcription;other metabolic processes","nucleus","","CDC40","ENSG00000168438","Spliceosome","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway","mRNA processing",1342.3,1290.8,1468.9,1884.7,2035.2,1401.4,0.7708642624922482,-0.3754512491043031,0.10983523314239509,0.9592583237763727,0.33702171244238693,0.4723421190391584,2382]
["O60512","beta-1,4-galactosyltransferase 3 [OS=Homo sapiens]",22,6,13,6,393,43.9,9.25,41.19,"protein metabolism;other metabolic processes","other membranes;cytosol;ER/Golgi","other molecular function","B4GALT3","ENSG00000158850","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Other types of O-glycan biosynthesis; Mannose type O-glycan biosynthesis; Glycosaminoglycan biosynthesis; Glycosphingolipid biosynthesis; Metabolic pathways","N-Glycan antennae elongation; Keratan sulfate biosynthesis","",466.5,497.1,499.3,592,681.3,877.6,0.6801338974382817,-0.5561092982978826,0.05422913762623413,1.2657673018368252,0.24406451164417814,0.6124953648580087,1624]
["O60518","ran-binding protein 6 [OS=Homo sapiens]",7,6,30,3,1105,124.6,5.01,74.1,"transport","nucleus;other cell component","other molecular function","RANBP6","ENSG00000137040","","","",179.1,188.8,173.5,196.5,195.8,258,0.8325388282331232,-0.26441053622529326,0.16042518590348034,0.7947274487685226,0.39909723749780046,0.3989212783387874,2938]
["O60524","nuclear export mediator factor NEMF [OS=Homo sapiens]",16,16,29,16,1076,122.9,6.35,83.71,"protein metabolism;other metabolic processes;transport","nucleus;other cell component","translation activity;nucleic acid binding activity","NEMF","ENSG00000165525","","","",3502.2,3418.1,3510.5,3779.2,3725.1,3271.4,0.9679927986116911,-0.046931780286094536,0.5211891643017273,0.28300462199415266,0.6697207457597266,0.1741062478318896,5688]
["O60547-1","GDP-mannose 4,6 dehydratase [OS=Homo sapiens]",32,11,32,11,372,41.9,7.31,83.54,"other metabolic processes;signal transduction","cytosol;other cell component","other molecular function","GMDS","ENSG00000112699; ENSPPAG00000026874; ENSPPYG00000016168; ENSPTRG00000017663","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars","GDP-fucose biosynthesis","",3950.5,3969.2,4221.2,3581.9,3324.7,3696.9,1.1449898618380723,0.19533482422554685,0.021792598134364443,1.661690989664105,0.15570097728648066,0.8077086614922921,1023]
["O60551","Glycylpeptide N-tetradecanoyltransferase 2 [OS=Homo sapiens]",20,8,34,4,498,56.9,7.58,109.02,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","NMT2","ENSG00000152465","","Membrane binding and targetting of GAG proteins; Inactivation, recovery and regulation of the phototransduction cascade","",462.4,459.4,449.6,414.8,367.4,2429.6,0.4269879818170496,-1.2277326311702854,0.4177663448900734,0.3790665495573672,0.5966108274328931,0.22430886922456086,5118]
["O60563","Cyclin-T1 [OS=Homo sapiens]",18,11,17,11,726,80.6,8.78,48.91,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","CCNT1","ENSG00000129315","Transcriptional misregulation in cancer","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interactions of Tat with host cellular proteins","Initiation of transcription and translation elongation at the HIV-1 LTR; Male infertility",1712.6,1830.8,1778.8,1881.5,1950,1825.1,0.9408832160661881,-0.08791243044360432,0.08851932482929167,1.0529619072620777,0.3043216110899778,0.5166672055653828,2126]
["O60566","Mitotic checkpoint serine/threonine-protein kinase BUB1 beta [OS=Homo sapiens]",20,18,29,18,1050,119.5,5.27,70.87,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","BUB1B","ENSG00000156970","Cell cycle; Human T-cell leukemia virus 1 infection","Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A","Regulation of sister chromatid separation at the metaphase-anaphase transition",2823.3,2697,2902.3,3456.6,3177.8,3709.4,0.8142655503780043,-0.29642872823792554,0.017734748774289853,1.7511749592479962,0.1430720516460094,0.8444451950408363,906]
["O60568","Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 [OS=Homo sapiens]",28,18,49,18,738,84.7,6.05,140.33,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;other membranes;ER/Golgi","other molecular function","PLOD3","ENSG00000106397","Lysine degradation; Other types of O-glycan biosynthesis; Metabolic pathways","Collagen biosynthesis and modifying enzymes","VEGFA-VEGFR2 signaling pathway; IL-18 signaling pathway",5724.4,5687.3,5954.7,5670.6,5357.1,7017.2,0.9623993482923152,-0.05529242932242039,0.6838214223870787,0.1650572979840476,0.7845002003181852,0.10540694118211608,6371]
["O60573","eukaryotic translation initiation factor 4E type 2 [OS=Homo sapiens]",27,6,12,6,245,28.3,8.88,35.32,"protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF4E2","ENSG00000135930","EGFR tyrosine kinase inhibitor resistance; HIF-1 signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Longevity regulating pathway; Insulin signaling pathway","ISG15 antiviral mechanism","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; EGFR tyrosine kinase inhibitor resistance",1536,1506.6,1500.7,2053.8,2003.7,1392.3,0.8336636206833278,-0.26246271441349156,0.22886285259349648,0.6404246932270785,0.4697440577382381,0.32813870501735914,3561]
["O60583-2","Isoform 2 of Cyclin-T2 [OS=Homo sapiens]",4,2,2,2,663,73.6,9.14,4.4,"","","","CCNT2","","","","",22.4,41.4,25.2,36.3,33,33.6,0.8649173955296403,-0.20936574104020858,0.483648039194592,0.3154705686033312,0.643543331234894,0.19142220574071714,5493]
["O60610-1","Protein diaphanous homolog 1 [OS=Homo sapiens]",51,64,287,62,1272,141.3,5.41,788.76,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","DIAPH1","ENSG00000131504","Focal adhesion; Regulation of actin cytoskeleton; AGE-RAGE signaling pathway in diabetic complications; Shigellosis","RHOA GTPase cycle; RHOC GTPase cycle; RHO GTPases Activate Formins; RHOB GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; ERBB2 Regulates Cell Motility","Microtubule cytoskeleton regulation; AGE/RAGE pathway; Focal adhesion; Type 2 papillary renal cell carcinoma; Regulation of actin cytoskeleton; G13 signaling pathway",31209.2,31255.2,31916.5,30399,29739.8,31001.7,1.0355538975537768,0.050402643572894486,0.06596578464040695,1.1806812674111704,0.26564403302299416,0.5756999348993287,1815]
["O60613-1","selenoprotein F [OS=Homo sapiens]",30,4,18,4,162,17.8,5.03,52.18,"","","","","","","","",1828.8,1756.5,1700.6,1766.6,1898.4,2401,0.8713979558193207,-0.1985963659959845,0.2569343279279566,0.5901778675759438,0.493673239438863,0.3065604139573472,3804]
["O60637","Tetraspanin-3 [OS=Homo sapiens]",6,2,4,2,253,28,5.81,9.72,"","plasma membrane;other membranes","","TSPAN3","ENSG00000140391","","","",782.9,790.3,742.6,749.3,750.9,1351.9,0.8119631148977946,-0.30051390339155737,0.424361817257294,0.3722636994654704,0.6006313947198997,0.22139197117588008,5164]
["O60645","exocyst complex component 3 [OS=Homo sapiens]",18,12,32,12,756,86.8,6.11,85.84,"","","","","","","","",3151,3093.1,3229,3159.2,2964.1,2478.7,1.1012671471750757,0.13916448266610162,0.23167886023886,0.6351135920212385,0.47050313683962985,0.3274374767901768,3599]
["O60664-1","Perilipin-3 [OS=Homo sapiens]",58,23,80,23,434,47,5.44,261.45,"transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","PLIN3","ENSG00000105355","","RHOBTB3 ATPase cycle; Late endosomal microautophagy; Triglyceride catabolism; Retrograde transport at the Trans-Golgi-Network; Lipophagy; Chaperone Mediated Autophagy","",10250.1,10617.6,10348.1,10852.4,10944.6,10650.6,0.9620372539109211,-0.05583533291710121,0.04271861907670207,1.3693827947683932,0.21547990809635295,0.6665932183555949,1449]
["O60669","monocarboxylate transporter 2 [OS=Homo sapiens]",5,3,6,3,478,52.2,9.31,15.05,"transport","plasma membrane;other membranes;nucleus","transporter activity","SLC16A7","ENSG00000118596","","Proton-coupled monocarboxylate transport","Male infertility",833.8,929.5,876.7,772.5,884.6,792.5,1.077726975832789,0.10799174163339022,0.22475202665181176,0.6482963834224078,0.4664146969898047,0.33122777316969293,3522]
["O60671-1","Cell cycle checkpoint protein RAD1 [OS=Homo sapiens]",20,4,10,4,282,31.8,4.83,32.83,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RAD1","ENSCCAG00000029737; ENSG00000113456; ENSGGOG00000004219; ENSMFAG00000012657; ENSMMUG00000045918; ENSPANG00000024799; ENSPPAG00000028406; ENSPPYG00000015389; ENSPTRG00000016783","Cellular senescence","Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA)","miRNA regulation of DNA damage response; ATR signaling; DNA damage response",862.2,901.4,1017.6,959.4,843,813.7,1.0631092083635945,0.08828980596768492,0.44144262402737966,0.35512573531989083,0.6113118868920269,0.21373715931994874,5278]
["O60674","Tyrosine-protein kinase JAK2 [OS=Homo sapiens]",2,2,2,2,1132,130.6,7.21,5.57,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","JAK2","ENSG00000096968","EGFR tyrosine kinase inhibitor resistance; Chemokine signaling pathway; PI3K-Akt signaling pathway; Necroptosis; Signaling pathways regulating pluripotency of stem cells; JAK-STAT signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; Cholinergic synapse; Prolactin signaling pathway; Adipocytokine signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Leishmaniasis; Toxoplasmosis; Tuberculosis; Hepatitis B; Influenza A; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Pathways in cancer; Chemical carcinogenesis; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis","RMTs methylate histone arginines; Potential therapeutics for SARS; Signaling by BRAF and RAF1 fusions; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Signaling by SCF-KIT; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Interleukin-4 and Interleukin-13 signaling; Cyclin D associated events in G1; Factors involved in megakaryocyte development and platelet production; Growth hormone receptor signaling; Interleukin-6 signaling; Signaling by Leptin; Regulation of IFNG signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; RAF activation; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; Prolactin receptor signaling; IL-6-type cytokine receptor ligand interactions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-12 signaling; Interleukin-23 signaling; Interleukin-27 signaling; Erythropoietin activates Phospholipase C gamma (PLCG); Erythropoietin activates STAT5; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants","IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Mesodermal commitment pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Mesodermal commitment pathway; IL-6 signaling pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; PI3K-Akt signaling pathway; Immune response to tuberculosis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; EGF/EGFR signaling pathway; Overview of interferons-mediated signaling pathway; Gastrin signaling pathway; Hepatitis B infection; EGFR tyrosine kinase inhibitor resistance; mBDNF and proBDNF regulation of GABA neurotransmission; 16p11.2 distal deletion syndrome; CCL18 signaling pathway; EPO receptor signaling; Notch signaling pathway (Netpath); Type II interferon signaling (IFNG); Serotonin receptor 2 and STAT3 signaling",32.3,40.2,37.4,39.7,33.7,33.3,1.029990627928772,0.04263121012480589,0.748386005099958,0.12587434245034335,0.8297866066862247,0.08103357925542974,6592]
["O60678","protein arginine N-methyltransferase 3 [OS=Homo sapiens]",7,3,4,3,531,59.8,5.35,11.5,"","","","","","","","",186.1,180.1,194.1,186.8,189.4,173.7,1.0189125295508272,0.027030205969148128,0.6129619717830705,0.21256646831530168,0.733487074617299,0.1346075348157123,6108]
["O60683-1","Peroxisome biogenesis factor 10 [OS=Homo sapiens]",11,2,2,2,326,37,9.99,7.37,"cell organization and biogenesis;transport","other membranes;other cytoplasmic organelle","other molecular function","PEX10","ENSG00000157911","Peroxisome","E3 ubiquitin ligases ubiquitinate target proteins; Peroxisomal protein import","Male infertility",262.9,250.1,238.8,233.5,222.1,712.8,0.6434440260184867,-0.6361134427861622,0.4392639681881146,0.35727441945004285,0.6099126792338392,0.21473233817196896,5264]
["O60684","Importin subunit alpha-7 [OS=Homo sapiens]",40,20,64,15,536,60,4.98,212.03,"transport;other biological processes","nucleus;other cell component","other molecular function","KPNA6","ENSG00000025800","Nucleocytoplasmic transport; Influenza A; Chemical carcinogenesis","Assembly of the ORC complex at the origin of replication","",6984.8,6965.5,6996.8,7048.3,7090.5,5137.5,1.0866763849908954,0.11992236605005202,0.43602378267381703,0.3604898217352847,0.608186608313536,0.2159631468350384,5240]
["O60701","UDP-glucose 6-dehydrogenase [OS=Homo sapiens]",27,10,21,10,494,55,7.12,73.03,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes","cytosol;nucleus","other molecular function","UGDH","ENSG00000109814","Pentose and glucuronate interconversions; Ascorbate and aldarate metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars","Formation of the active cofactor, UDP-glucuronate","Glucuronidation",2066.7,2165.8,2024.2,2047.8,1980.8,2457.5,0.9646320593268682,-0.051949336349554794,0.647196512142818,0.18896383187972945,0.7583134509861906,0.12015124041688145,6238]
["O60704","Protein-tyrosine sulfotransferase 2 [OS=Homo sapiens]",7,2,2,2,377,41.9,9.09,6.91,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","TPST2","ENSG00000128294","","Cytosolic sulfonation of small molecules; Gamma carboxylation, hypusine formation and arylsulfatase activation; Defective F8 sulfation at Y1699","",237.8,255.1,287,266.2,271.7,232.7,1.0120685180378926,0.01730696521726337,0.8774920979933067,0.056756785760548385,0.9157038469778811,0.03824496128798393,7004]
["O60711-1","Leupaxin [OS=Homo sapiens]",36,11,87,11,386,43.3,6.01,336.59,"cell adhesion;cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","LPXN","ENSG00000110031","","","",7813.2,8089.4,7625,7934.7,7964.5,9958.9,0.9098735019200946,-0.13626211093665355,0.319049372741916,0.4961421048732537,0.540675136881675,0.2670636011352324,4313]
["O60725","protein-s-isoprenylcysteine O-methyltransferase [OS=Homo sapiens]",6,2,3,2,284,31.9,7.96,7.07,"protein metabolism;other metabolic processes;transport","other membranes;ER/Golgi","other molecular function","ICMT","ENSG00000116237","Terpenoid backbone biosynthesis","RAS processing; Gamma carboxylation, hypusine formation and arylsulfatase activation","Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome",596,634.2,549.7,503.6,502.5,1101.3,0.8445952358356269,-0.24366798563081388,0.6157412892195744,0.21060172333072813,0.7363306745592064,0.13292710701438865,6112]
["O60733","85/88 kDa calcium-independent phospholipase A2 [OS=Homo sapiens]",1,1,1,1,806,89.8,7.27,2.59,"other metabolic processes;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component","other molecular function","PLA2G6","ENSG00000184381","Glycerophospholipid metabolism; Ether lipid metabolism; Arachidonic acid metabolism; Linoleic acid metabolism; alpha-Linolenic acid metabolism; Metabolic pathways; Ras signaling pathway; Vascular smooth muscle contraction; Fc gamma R-mediated phagocytosis; Inflammatory mediator regulation of TRP channels","Role of phospholipids in phagocytosis; COPI-independent Golgi-to-ER retrograde traffic; Acyl chain remodelling of PC; Acyl chain remodelling of PE; Acyl chain remodeling of CL","Eicosanoid synthesis; Spinal cord injury; Ras signaling; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Eicosanoid metabolism via cyclooxygenases (COX); Omega-3 / omega-6 fatty acid synthesis",177.7,170.7,181.5,191.3,201.7,76.9,1.1276867418599703,0.17336635964222025,0.644169797030521,0.19099964165616404,0.7563433006419402,0.12128103553996505,6225]
["O60749","Sorting nexin-2 [OS=Homo sapiens]",43,20,66,18,519,58.4,5.12,199.82,"cell organization and biogenesis;transport","other membranes;cytosol;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","SNX2","ENSG00000205302","Endocytosis","Golgi Associated Vesicle Biogenesis","",7693.3,7753,7979.2,7414.6,7304.2,6584.4,1.0996235307371665,0.13700968438492472,0.06149222716792186,1.2111797770932224,0.2575625721320005,0.5891172465044483,1745]
["O60759","cytohesin-interacting protein [OS=Homo sapiens]",12,2,3,2,359,40,6.99,8.96,"other biological processes","cytosol;nucleus;other cytoplasmic organelle;other cell component","","CYTIP","ENSG00000115165","","","Amplification and expansion of oncogenic pathways as metastatic traits",202.7,211.2,205.8,227.7,247.2,187.2,0.9359613351457486,-0.09547916202915983,0.47266173246456517,0.3254495575283205,0.6359875925227368,0.19655135691679285,5432]
["O60762","Dolichol-phosphate mannosyltransferase subunit 1 [OS=Homo sapiens]",47,10,50,10,260,29.6,9.57,123.59,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","DPM1","ENSG00000000419","N-Glycan biosynthesis; Metabolic pathways","Synthesis of dolichyl-phosphate mannose; Defective DPM1 causes DPM1-CDG (CDG-1e); Defective DPM3 causes DPM3-CDG (CDG-1o); Defective DPM2 causes DPM2-CDG (CDG-1u)","VEGFA-VEGFR2 signaling pathway",7109.4,7312.5,7037.9,7693.1,6668,5618.6,1.074080191394265,0.103101709718035,0.4602186174515234,0.337035816582371,0.6252300882812611,0.20396013036478716,5380]
["O60763-1","General vesicular transport factor p115 [OS=Homo sapiens]",48,41,195,41,962,107.8,4.91,605.23,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","","USO1","ENSG00000138768","","COPI-mediated anterograde transport; COPII-mediated vesicle transport; Golgi Cisternae Pericentriolar Stack Reorganization","",21212.4,20979,21244.7,21250.5,21834.1,16130,1.071291539586521,0.09935114626877128,0.4811937578639927,0.3176800150454233,0.6419137025420556,0.19252335359616013,5479]
["O60783","28S ribosomal protein S14, mitochondrial [OS=Homo sapiens]",12,1,3,1,128,15.1,11.41,11.73,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus","other molecular function","MRPS14","ENSG00000120333","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",31.5,41.5,34.8,31.4,43.4,77.3,0.7087442472057857,-0.49666297497199124,0.3527103383135312,0.452581810514771,0.5614024091318814,0.25072572802071513,4592]
["O60784","Target of Myb protein 1 [OS=Homo sapiens]",57,19,81,19,492,53.8,4.7,205.96,"transport;signal transduction","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","TOM1","ENSG00000100284","","Neutrophil degranulation","",4387.2,4382.5,4532.8,4893,4972.1,6049.1,0.8358887031707531,-0.2586172316155967,0.08162610252713699,1.0881709396437549,0.2933162160131978,0.5326639263465076,2034]
["O60825-1","6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 [OS=Homo sapiens]",46,19,72,1,505,58.4,8.38,198.67,"other metabolic processes;other biological processes","cytosol;nucleus","kinase activity;other molecular function","PFKFB2","ENSG00000123836; ENSGGOG00000012227; ENSPPAG00000041619; ENSPTRG00000001925","Fructose and mannose metabolism; Metabolic pathways; AMPK signaling pathway; Thyroid hormone signaling pathway","Regulation of glycolysis by fructose 2,6-bisphosphate metabolism","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Thyroid hormones production and peripheral downstream signaling effects",4979.9,4991.4,5228.5,5229.1,4670.4,5312.8,0.9991782965100608,-1.1859548684003299E-3,0.9856203366302199,6.2903441455926514E-3,0.9895465714876753,0.004563761574656908,7280]
["O60825-2","Isoform 2 of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 [OS=Homo sapiens]",50,19,71,1,471,54.4,7.56,198.67,"","","","PFKFB2","","","","",144.9,138.7,133.8,125.4,114.2,134.1,1.116938720899117,0.15955003677909066,0.09174102620507699,1.0374364062063297,0.31014577267942073,0.5084341339396484,2162]
["O60826","Coiled-coil domain-containing protein 22 [OS=Homo sapiens]",26,14,30,14,627,70.7,6.74,85.37,"transport;other biological processes","cytosol;nucleus;other cytoplasmic organelle","other molecular function","CCDC22","ENSG00000101997","","Neddylation","",2477.2,2489.3,2362.4,2573.7,2576.3,2127.6,1.0070490271518082,0.010133921186818705,0.9172118318635308,0.03753035158721542,0.945010047799626,0.02456357383916638,7094]
["O60828","Polyglutamine-binding protein 1 [OS=Homo sapiens]",19,4,9,4,265,30.5,6.33,27.86,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","PQBP1","ENSG00000102103","Spliceosome","mRNA Splicing - Major Pathway","",675.4,663.1,746.4,937,943.8,1001.3,0.7233961347628466,-0.46714220545514995,1.2933676802400875E-3,2.8882779957692644,0.04417394567698505,1.3548338072344819,214]
["O60830-1","Mitochondrial import inner membrane translocase subunit Tim17-B [OS=Homo sapiens]",30,5,15,5,172,18.3,9.03,43.72,"cell organization and biogenesis;transport","other membranes;mitochondrion","transporter activity","TIMM17B","ENSG00000126768; ENSGGOG00000011427; ENSNLEG00000007902; ENSPPAG00000036547; ENSPPYG00000020323; ENSPTRG00000021872","","Mitochondrial protein import","",1894.1,1988.6,1984.6,1912.9,2016.6,1980.8,0.992724565588887,-0.010534601684929782,0.7573588732549411,0.12069828200286584,0.8356787446588715,0.0779606438957166,6624]
["O60831","PRA1 family protein 2 [OS=Homo sapiens]",22,3,7,3,178,19.2,9.19,15.69,"transport","other membranes;other cytoplasmic organelle","","PRAF2","ENSG00000243279","","","",364,379.1,383.1,325.1,345,536.4,0.9334438458350601,-0.09936485955108317,0.7123997278595868,0.1472762551115205,0.805901503006612,0.09371803426771644,6461]
["O60832-1","H/ACA ribonucleoprotein complex subunit 4 [OS=Homo sapiens]",53,27,113,27,514,57.6,9.42,378.31,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DKC1","ENSG00000130826; ENSGGOG00000001045; ENSPTRG00000022449","Ribosome biogenesis in eukaryotes","rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase","",17166.2,17167.2,17122.9,17538.2,16910.5,17734.1,0.9860777880834299,-0.020226634840364154,0.3855608061091668,0.4139071204010724,0.5780643962773129,0.23802377855165507,4875]
["O60841","Eukaryotic translation initiation factor 5B [OS=Homo sapiens]",41,55,214,54,1220,138.7,5.49,606.45,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","EIF5B","ENSG00000158417","","GTP hydrolysis and joining of the 60S ribosomal subunit","Translation factors; Ciliary landscape",28234.9,26822.5,28256.1,28722.6,29131.3,18313.4,{"$f":"AVERAGE(S514:U514)/AVERAGE(V514:X514)","v":1.0938224146057431},{"$f":"LOG(Y514,2)","v":0.12937853121634252},{"$f":"TTEST(V514:X514,S514:U514,2,2)","v":0.5412934085423218},0.26656726138321685,{"$f":"AA514*7309/AE514","v":0.6807146460832467},0.16703490512522778,5812]
["O60861-1","Isoform 1 of Growth arrest-specific protein 7 [OS=Homo sapiens]",7,2,3,2,412,47.2,7.58,8.59,"","","","GAS7","","","","",310.3,255.4,266.4,580.2,576.6,168,0.6280948067632849,-0.6709457540444994,0.29929205286081795,{"$f":"-LOG10(AA515)","v":0.5239048148822142},0.5287709969445779,{"$f":"-LOG10(AC515)","v":0.2767323738937534},4137]
["O60869-1","Endothelial differentiation-related factor 1 [OS=Homo sapiens]",10,1,1,1,148,16.4,9.95,2.52,"developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","EDF1; LOC101354658; LOC113248658","ENSBIXG00000009641; ENSBIXG00005005090; ENSBTAG00000030302; ENSCATG00000040060; ENSCCAG00000020655; ENSCJAG00000011166; ENSCSAG00000016077; ENSECAG00000012630; ENSFCAG00000000388; ENSG00000107223; ENSLCNG00005013346; ENSPANG00000026162; ENSPCOG00000009350; ENSRFEG00010005371","","","",248.7,241.6,246.5,225.5,236.7,207.8,1.0997014925373134,0.13711196585883845,0.06210400446522687,1.2068803956192222,0.2579080503615586,0.588535101549399,1760]
["O60870","DNA/RNA-binding protein KIN17 [OS=Homo sapiens]",13,5,13,5,393,45.3,8.95,36.4,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response","nucleus;other cell component","nucleic acid binding activity;other molecular function","KIN","ENSG00000151657","","Protein methylation","",701.6,767.9,711.5,1031.1,998.5,1108,0.6951172870984192,-0.524671670664036,1.156822655290937E-3,2.936733214714573,0.04227608393760729,1.3739052484945815,200]
["O60879-2","Isoform 2 of Protein diaphanous homolog 2 [OS=Homo sapiens]",18,20,36,18,1096,124.7,6.43,109.53,"","","","DIAPH2","","","","",3807.1,3797.4,3892.5,3666.3,3801.7,2043.3,1.2087727229716234,0.2735430102897865,0.3069574136257145,0.5129218730904688,0.5345608139600542,0.2720028804179858,4197]
["O60884","DnaJ homolog subfamily A member 2 [OS=Homo sapiens]",37,14,52,14,412,45.7,6.48,156.08,"stress response;other biological processes","other membranes;cytosol","other molecular function","DNAJA2","ENSG00000069345","Protein processing in endoplasmic reticulum","HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand","",6518.9,6363.9,6285.6,6382.7,6463.7,6425.5,0.9946294864543714,-0.0077688934561929,0.6587077790153719,0.18130720772365697,0.7666393561820627,0.11540888957688009,6280]
["O60885-1","Bromodomain-containing protein 4 [OS=Homo sapiens]",4,5,6,5,1362,152.1,9.19,12.26,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","kinase activity;other molecular function","BRD4","ENSG00000141867; ENSPTRG00000010619","","Potential therapeutics for SARS","VEGFA-VEGFR2 signaling pathway; 7q11.23 copy number variation syndrome",323,318.6,309.7,2149.6,2182.1,1282.2,0.16945438999625928,-2.561031082179984,6.197889915705369E-3,2.207756141782809,0.08847729959744247,1.0531681408746667,512]
["O60888-1","Protein CutA [OS=Homo sapiens]",47,5,48,5,179,19.1,5.5,156.55,"other biological processes","other membranes","other molecular function","CUTA","ENSG00000112514; ENSG00000226492","","","",2632.9,2362.9,2299.5,2634.6,3118.3,2518.3,0.8820122835864203,-0.18112934687575605,0.19669395951229088,0.7062089770952099,0.4373702920825476,0.35915071929286135,3287]
["O60906","Sphingomyelin phosphodiesterase 2 [OS=Homo sapiens]",6,2,3,2,423,47.6,6.98,6.62,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","SMPD2","ENSG00000135587","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway","Glycosphingolipid metabolism; Ceramide signalling; TNFR1-mediated ceramide production","TNF-alpha signaling pathway; S1P receptor signal transduction",71.6,58.4,71,55.9,68.3,219.4,0.5849825378346915,-0.7735345350721727,0.41833160268074754,0.3784793255904688,0.5966020846816749,0.22431523343428778,5125]
["O60907","F-box-like/WD repeat-containing protein TBL1X [OS=Homo sapiens]",14,7,25,2,577,62.5,6.55,91.11,"protein metabolism;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","TBL1X","ENSG00000101849","Wnt signaling pathway","Heme signaling; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; RORA activates gene expression","Ectoderm differentiation; Ectoderm differentiation; Rett syndrome causing genes",56.6,62.6,57.5,63.8,61,102.8,0.7763620386643234,-0.365198517754965,0.2808405512155757,0.5515401832315517,0.5144520272768528,0.28865511703432706,3990]
["O60921","checkpoint protein HUS1 [OS=Homo sapiens]",20,4,9,4,280,31.7,6.84,31.78,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","","HUS1","ENSG00000136273","Cellular senescence","Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA)","ATR signaling",375.5,379.7,389.7,358.7,362,307.9,1.113066303713786,0.15453953444983703,0.09768892652376886,1.0101546627109268,0.3200396073340325,0.4947962711107915,2231]
["O60925","prefoldin subunit 1 [OS=Homo sapiens]",8,1,1,1,122,14.2,6.81,3.51,"other biological processes","other cell component","other molecular function","PFDN1","ENSG00000113068","","Prefoldin mediated transfer of substrate  to CCT/TriC","Cellular proteostasis",131.7,133.7,104.7,134.5,170.2,154.9,0.8052654482158397,-0.3124636623458931,0.09910513579831297,1.0039038390457675,0.3225108804763444,0.49145562908723356,2246]
["O60927","Protein phosphatase 1 regulatory subunit 11 [OS=Homo sapiens]",12,1,2,1,126,13.9,7.01,8.98,"protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","enzyme regulator activity;other molecular function","PPP1R11","ENSG00000204619; ENSG00000206501; ENSG00000227720; ENSG00000233314; ENSG00000234058; ENSG00000236560; ENSG00000237403; ENSG00000237829","","","",97.3,111.5,108.1,154.3,154.1,211.2,0.6098922247882987,-0.7133737710656474,0.025603032310607277,1.5917085957125168,0.16889220501645177,0.7723903942209548,1108]
["O60930","Ribonuclease H1 [OS=Homo sapiens]",7,2,3,2,286,32,9.16,10.07,"RNA metabolism OR transcription;other metabolic processes","other cell component","nucleic acid binding activity;other molecular function","RNASEH1","ENSG00000171865","DNA replication","","",400.3,405.1,401.9,415.2,389.8,467.9,0.9484641370099773,-0.07633487089322599,0.39638669611693966,0.40188093012006143,0.5849364752511027,0.2328912962185446,4953]
["O60934","Nibrin [OS=Homo sapiens]",12,7,14,7,754,84.9,6.9,28.06,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NBN","ENSG00000104320","Homologous recombination; Cellular senescence","Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks","miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM signaling in development and disease ; Breast cancer pathway; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; DNA damage response",1243.8,1204.5,1195.5,1486.5,1639.8,1418.9,0.8016808941300713,-0.3189000029311276,0.010956852170581573,1.9603141977955105,0.11489760762522341,0.939689014009547,697]
["O60942-1","mRNA-capping enzyme [OS=Homo sapiens]",19,10,25,10,597,68.5,8.13,62.35,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","RNGTT","ENSG00000111880; ENSGGOG00000007863; ENSNLEG00000013064; ENSPPAG00000024828; ENSPTRG00000018413","mRNA surveillance pathway","RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE","mRNA processing; Ciliary landscape; mRNA Processing",1828.3,1846.7,1844.8,1834.7,1902.7,2316.3,0.9118060029403504,-0.13320118756693264,0.30277036604236984,0.5188866341061812,0.5306831188018419,0.27516472719596585,4170]
["O75027-1","ATP-binding cassette sub-family B member 7, mitochondrial [OS=Homo sapiens]",26,17,33,16,752,82.6,9.33,94.31,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","ABCB7","ENSG00000131269","ABC transporters","Mitochondrial ABC transporters; Cytosolic iron-sulfur cluster assembly","",3478.5,3510.6,3519.8,2939,3176.3,3174.4,1.1312421283787422,0.1779077533994114,7.0098157292369295E-3,2.1542933984138597,0.09487915400924576,1.0228291963528555,540]
["O75037","Kinesin-like protein KIF21B [OS=Homo sapiens]",8,10,15,9,1637,182.5,7.08,40.29,"other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF21B","ENSG00000116852","","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",857.5,851.2,848.3,1111.7,1013.6,2361,0.5699574259411988,-0.8110739364475965,0.2122802700183209,0.6730903686241849,0.45353887563984435,0.3433854809252745,3421]
["O75044","SLIT-ROBO Rho GTPase-activating protein 2 [OS=Homo sapiens]",31,28,60,28,1071,120.8,6.7,171.11,"","","","","","","","",7317.1,7348,7450.2,6965.9,6721.1,6491.6,1.0959779171994093,0.13221872980586752,0.010632999064586668,1.973344224329001,0.11246973974394205,0.9489643098192263,691]
["O75052","Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein [OS=Homo sapiens]",12,5,15,4,506,56.1,6.3,29.74,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","NOS1AP","ENSG00000198929","Circadian entrainment","","Sudden infant death syndrome (SIDS) susceptibility pathways",382.1,362.5,411.4,401.4,400,780.2,0.7309054122407689,-0.45224337834116674,0.3275242303146195,0.4847565652823535,0.5457990422639203,0.2629672307398846,4386]
["O75063","Glycosaminoglycan xylosylkinase [OS=Homo sapiens]",15,5,12,5,409,46.4,6.87,36.6,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;nucleus","kinase activity;other molecular function","FAM20B","ENSG00000116199","","","",840.5,854.5,890.5,863.6,888.8,1116.4,0.9012479085331846,-0.15000408849762353,0.31240940598193656,0.5052758989158752,0.5379034978379209,0.26929563161187375,4245]
["O75064","DENN domain-containing protein 4B [OS=Homo sapiens]",4,5,8,5,1496,163.7,7.21,29.61,"other biological processes","cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity","DENND4B","ENSG00000198837","","RAB GEFs exchange GTP for GDP on RABs","",504.8,520.6,605.3,523.3,483.8,1231.7,0.7283812756834018,-0.4572342590991235,0.45450677659644084,0.3424596371581849,0.6209327159146516,0.2069554572954404,5350]
["O75071","EF-hand calcium-binding domain-containing protein 14 [OS=Homo sapiens]",3,2,2,2,495,55,6.32,2.24,"","","other molecular function","EFCAB14","ENSG00000159658","","","",188.8,200.5,196.6,210.3,222.6,379.4,0.7212852394435553,-0.47135819443459404,0.23866512642032153,0.6222110351603275,0.47648276673207596,0.32195280215788563,3661]
["O75083","WD repeat-containing protein 1 [OS=Homo sapiens]",66,28,263,28,606,66.2,6.65,1018.95,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity","WDR1","ENSG00000071127","","Platelet degranulation","Hypertrophy model",28681.6,30479.5,30141,28306.9,25728,25594,1.1214785084309844,0.1654019734539409,0.036309889363631824,1.4399750743819961,0.1962936252653735,0.7070938041036403,1352]
["O75093-1","Slit homolog 1 protein [OS=Homo sapiens]",1,1,1,1,1534,167.8,6.57,1.87,"cell organization and biogenesis;transport;developmental processes;other biological processes","non-structural extracellular","signal transduction activity or receptor binding;other molecular function","SLIT1","ENSG00000187122","Axon guidance","Regulation of expression of SLITs and ROBOs; Netrin-1 signaling; Regulation of cortical dendrite branching; Regulation of commissural axon pathfinding by SLIT and ROBO","Spinal cord injury",246.4,237.8,200.1,273.9,262.7,391.5,0.7373127895700896,-0.4396513124336943,0.13563955783423448,0.867613634630202,0.3708902088329292,0.43075463150276627,2673]
["O75113","NEDD4-binding protein 1 [OS=Homo sapiens]",19,12,17,12,896,100.3,5.36,60.04,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","N4BP1","ENSG00000102921","","","",861.7,786,869,937.6,904.2,834.9,0.9402249037994543,-0.0889222010902945,0.25561916685442365,0.5924065849931905,0.492051748890962,0.3079892202490147,3797]
["O75116","Rho-associated protein kinase 2 [OS=Homo sapiens]",29,34,65,28,1388,160.8,6.02,166.7,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;kinase activity;other molecular function","ROCK2","ENSG00000134318","cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Vascular smooth muscle contraction; Wnt signaling pathway; Axon guidance; Focal adhesion; Tight junction; Platelet activation; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Human cytomegalovirus infection; Pathways in cancer; Proteoglycans in cancer; Lipid and atherosclerosis","RHOA GTPase cycle; RHOB GTPase cycle; RHOC GTPase cycle; G alpha (12/13) signalling events; Potential therapeutics for SARS; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHOBTB1 GTPase cycle; RHOH GTPase cycle","Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Pathogenic Escherichia coli infection; Spinal cord injury; Focal adhesion; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; Wnt signaling; Airway smooth muscle cell contraction; Regulation of actin cytoskeleton; G13 signaling pathway",5278.9,4700.7,5266.4,5494.7,5485.7,4088.7,1.0117392545009323,0.016837526486416406,0.9126031924588534,0.03971801631632897,0.9415890363751778,0.02613860695039314,7084]
["O75122","CLIP-associating protein 2 [OS=Homo sapiens]",29,29,71,1,1294,141,8.47,187.27,"","","","","","","","",18.6,15.1,18.7,16,21.4,30.2,0.775147928994083,-0.3674564347447337,0.304392423097341,0.516566162177316,0.53186808998768,0.27419606487397324,4183]
["O75122-3","Isoform 3 of CLIP-associating protein 2 [OS=Homo sapiens]",24,29,71,1,1515,165.8,8.37,188.79,"","","","","","","","",5389.4,5375,5287.6,5824.7,5843.1,7082.7,0.8560838377643263,-0.22417600573278054,0.09749706279497575,1.0110084676978597,0.3199847471793793,0.4948707228479249,2227]
["O75127","pentatricopeptide repeat-containing protein 1, mitochondrial [OS=Homo sapiens]",15,8,17,8,700,78.8,8.59,43.17,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","nucleic acid binding activity","PTCD1","ENSG00000106246","","","",1484.5,1443,1483,1658.4,1671.1,1816.2,0.8571234234409313,-0.2224251314302219,0.009475578094609817,2.0233942847223854,0.10720897878251262,0.9697688408334963,646]
["O75131","Copine-3 [OS=Homo sapiens]",46,20,84,19,537,60.1,5.85,274.59,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","CPNE3","ENSG00000085719","","Neutrophil degranulation; Glycerophospholipid biosynthesis","",10428.7,10460,10650,9807.3,9514,11112.7,1.0362982190970624,0.05143923207927713,0.4992396560600227,0.30169092467977754,0.6545188602946557,0.18407783451600293,5575]
["O75132","Zinc finger BED domain-containing protein 4 [OS=Homo sapiens]",2,2,2,2,1171,130.2,6.83,7.41,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBED4","ENSG00000100426","","","",119.8,121.3,131.9,140.7,137,218.8,0.7512588116817723,-0.41261808727313626,0.20123775983624614,0.6962905258532062,0.44262617714207736,0.3539629052479442,3323]
["O75140-1","Isoform 1 of GATOR complex protein DEPDC5 [OS=Homo sapiens]",8,9,10,9,1572,177.8,6.73,33.77,"","","","DEPDC5","","","","",651.1,633.6,662.4,700.4,665.7,851.7,0.877942104788529,-0.18780228939600002,0.19298261313134757,0.7144818172163697,0.43386955379176234,0.36264082482852344,3251]
["O75143-1","Autophagy-related protein 13 [OS=Homo sapiens]",17,5,9,5,517,56.5,5.12,27.52,"cell organization and biogenesis;other metabolic processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cell component","other molecular function","ATG13","ENSG00000175224","Autophagy; Autophagy; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration","Macroautophagy","Alzheimer's disease and miRNA effects; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Host-pathogen interaction of human coronaviruses - autophagy; Autophagy; Malignant pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; Senescence and autophagy in cancer",679.6,744.4,675.2,939.2,911.7,1145.8,0.700503887609704,-0.5135350376364402,0.0179063541484784,1.74699283036422,0.14366360315173285,0.842653245453245,911]
["O75144-1","ICOS ligand [OS=Homo sapiens]",4,1,1,1,302,33.3,5.31,2.94,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","ICOSLG","ENSG00000160223","Cell adhesion molecules; Intestinal immune network for IgA production","Costimulation by the CD28 family","",73.4,91.1,84,88.8,92.6,147,0.7566991473812424,-0.40220827532815623,0.24354155973847472,0.6134269168929625,0.4810933135482464,0.31777067907598455,3700]
["O75145-1","Liprin-alpha-3 [OS=Homo sapiens]",1,2,2,1,1194,133.4,5.68,4.59,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","non-structural extracellular;cytosol;other cell component","","PPFIA3","ENSG00000177380","","Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Receptor-type tyrosine-protein phosphatases","",243.8,278.7,288,330,301.1,639.1,0.6380884900015745,-0.6481715843238417,0.23251806697170632,0.6335432961879137,0.47129077967171423,0.3267110566903239,3606]
["O75146","Huntingtin-interacting protein 1-related protein [OS=Homo sapiens]",25,25,37,25,1068,119.3,6.67,110.28,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component","cytoskeletal activity;other molecular function","HIP1R","ENSG00000130787","","Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis","",3458.2,3433.9,3512.7,3500.6,3424.6,5411.7,0.8433885335862331,-0.24573068751116364,0.3781820229565226,0.4222991193734292,0.5737095072206774,0.2413079531517808,4818]
["O75150","E3 ubiquitin-protein ligase BRE1B [OS=Homo sapiens]",39,36,87,33,1001,113.6,6.23,274.24,"protein metabolism;other metabolic processes","nucleus","other molecular function","RNF40","","","","",7278.4,6851.5,7454.9,7649.3,7730.5,8338.4,0.9100521962037592,-0.13597880117519207,0.06505453737552712,1.1867224071972193,0.26386438050928285,0.5786192319562905,1802]
["O75151","lysine-specific demethylase phf2 [OS=Homo sapiens]",7,6,6,6,1096,120.7,9.17,14.18,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","other molecular function","PHF2","ENSG00000197724","","HDMs demethylate histones","",301.9,264.7,284.6,321.9,347,450.6,0.7603394372487716,-0.39528447223877056,0.09364517280052628,1.0285146046221831,0.313681286892322,0.5035113889905333,2182]
["O75152","Zinc finger CCCH domain-containing protein 11A [OS=Homo sapiens]",35,26,48,26,810,89.1,8.37,125.72,"other metabolic processes;transport","nucleus","nucleic acid binding activity;other molecular function","ZC3H11A","ENSG00000058673","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","",5959.1,5764.5,6023.8,6431.8,6612.9,5477.3,0.958179462261095,-0.06163220399231669,0.5137347744501551,0.28926103610422665,0.6649349152569832,0.17722086195713285,5647]
["O75153","Clustered mitochondria protein homolog [OS=Homo sapiens]",24,22,46,22,1309,146.6,6.13,135.35,"cell organization and biogenesis","other cell component","nucleic acid binding activity","CLUH","ENSG00000132361","","","Translation factors",4786.9,4762.9,4667.6,6413.4,6103.6,4640.8,0.8286260476284838,-0.2712069231415735,0.14809220194845185,0.8294678094053302,0.38547218804887273,0.4140069509791249,2808]
["O75157","TSC22 domain family protein 2 [OS=Homo sapiens]",6,5,11,3,780,79.2,5.02,19.03,"stress response;other biological processes","","","TSC22D2","ENSG00000196428","","","",583.1,596.6,598.2,571.1,605.2,538.3,1.0369182316575294,0.05230213192035782,0.34875289600047304,0.4574821773762584,0.5581420882127124,0.25325522709928605,4567]
["O75164-1","Lysine-specific demethylase 4A [OS=Homo sapiens]",12,9,18,9,1064,120.6,5.85,58.62,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","KDM4A","ENSG00000066135","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux","",919.1,886.6,942.8,1137.1,1113.6,1404.9,0.7518601597548966,-0.41146373828850363,0.03327346259467468,1.4779020020313272,0.1901452213483012,0.7209145846260082,1279]
["O75165","DnaJ homolog subfamily C member 13 [OS=Homo sapiens]",30,57,155,57,2243,254.3,6.74,473.49,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","","DNAJC13","ENSG00000138246","","Neutrophil degranulation","",14664,15087.4,14868.7,14905.2,14569.8,18052.4,0.9388289702361166,-0.09106573388363212,0.43415669959491987,0.36235349286851576,0.6081355533421368,0.2159996057487447,5218]
["O75167","Phosphatase and actin regulator 2 [OS=Homo sapiens]",2,2,2,1,634,69.7,8.16,3.9,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes","enzyme regulator activity;cytoskeletal activity","PHACTR2","ENSG00000112419","","Platelet degranulation","",43.8,45.2,48.1,52.1,47.1,204.9,0.45083853995396245,-1.149317245251572,0.3430555256138645,0.4646355810765763,0.554610227098371,0.2560121262268976,4521]
["O75170","Serine/threonine-protein phosphatase 6 regulatory subunit 2 [OS=Homo sapiens]",25,14,27,14,966,104.9,4.87,59.4,"other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP6R2","ENSG00000100239","","","",986.5,1026.4,1004.1,1037.9,1065.8,952.8,0.9870767217405528,-0.018765870618143794,0.7323209038357732,0.13529856890704414,0.8193071308947905,0.08655326521288373,6533]
["O75175","CCR4-NOT transcription complex subunit 3 [OS=Homo sapiens]",7,5,14,5,753,81.8,6.2,35.81,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","","CNOT3","ENSG00000088038; ENSG00000273943; ENSG00000274176; ENSG00000274616; ENSG00000274941; ENSG00000275979; ENSG00000276082; ENSG00000277114; ENSG00000277600; ENSG00000277615","RNA degradation","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","",892.5,779.6,883.9,1192.6,1226.6,1051.6,0.7364296415811917,-0.4413803979910302,0.009221354228639605,2.0352052946907047,0.10681280199227712,0.9713766920508661,631]
["O75177","Calcium-responsive transactivator [OS=Homo sapiens]",6,2,2,2,396,43,6.44,5.82,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","SS18L1","ENSG00000184402","","","",166.2,181.1,177.8,218.1,211.6,225.2,0.8018018018018017,-0.3186824353837084,1.9441478036463682E-3,2.711270720959163,0.052434598881370136,1.2803820499495957,271]
["O75179-1","Ankyrin repeat domain-containing protein 17 [OS=Homo sapiens]",14,29,48,17,2603,274.1,6.52,133.09,"stress response;developmental processes;other biological processes","other membranes;nucleus;other cell component","other molecular function","ANKRD17","ENSG00000132466","","","",3868.9,3881.2,3964,4840.6,4741.1,4272.8,0.8455086794904183,-0.2421085303248268,0.01589581412120196,1.7987172243210066,0.13572722594844056,0.8673330271141869,856]
["O75182-2","Isoform 2 of Paired amphipathic helix protein Sin3b [OS=Homo sapiens]",8,6,10,5,1130,129.3,6.98,26.85,"","","","SIN3B","","","","",170.4,167.2,186.9,191.9,203.3,184.1,0.9054030726739167,-0.14336789220717666,0.09165353198677445,1.0378507942826691,0.3101368820793215,0.5084465835496271,2160]
["O75190","DnaJ homolog subfamily B member 6 [OS=Homo sapiens]",30,8,18,7,326,36.1,9.16,53.64,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","DNAJB6","ENSG00000105993","","Regulation of HSF1-mediated heat shock response","",1578.5,1590.6,1557.8,1596.8,1618.9,1495.7,1.0032898926009255,4.7385213940666715E-3,0.9012896491548865,0.045135616552215756,0.933606298989947,0.0298362267920061,7056]
["O75191","xylulose kinase [OS=Homo sapiens]",4,2,2,2,536,58.3,5.86,6.13,"other metabolic processes","cytosol","kinase activity;other molecular function","XYLB","ENSG00000093217","Pentose and glucuronate interconversions; Metabolic pathways","Formation of xylulose-5-phosphate","",151.1,154.8,183.3,161.6,138.9,299.8,0.8149258703981342,-0.29525926409951075,0.510285002560217,0.2921871955342266,0.6621113232225503,0.1790689848856045,5633]
["O75208-1","Ubiquinone biosynthesis protein COQ9, mitochondrial [OS=Homo sapiens]",18,4,13,4,318,35.5,5.94,59.67,"other metabolic processes","other membranes;mitochondrion","other molecular function","COQ9","ENSG00000088682","","Ubiquinol biosynthesis","",839,830.6,853.3,644.7,741.2,613.2,1.2620179080586262,0.33573238233636166,0.011085755332440423,1.9552347107105064,0.1150934456318282,0.9389494079686456,704]
["O75223-1","gamma-glutamylcyclotransferase [OS=Homo sapiens]",54,9,45,9,188,21,5.14,115.66,"cell organization and biogenesis;signal transduction","cytosol","other molecular function","C7orf24; GGCT","ENSG00000006625; ENSGGOG00000024930; ENSPPAG00000031715; ENSPTRG00000019041","Glutathione metabolism; Metabolic pathways","Glutathione synthesis and recycling","Gamma-glutamyl cycle for the biosynthesis and degradation of glutathione, including diseases",5110.5,5411.7,5503.4,5184.2,4634.5,3910,1.1673064456212168,0.22318335242580215,0.11943735675354737,0.9228598164689913,0.34904743722977916,0.4571155463155209,2501]
["O75251","NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [OS=Homo sapiens]",14,3,27,3,213,23.5,9.99,53.49,"cell organization and biogenesis;other metabolic processes;transport","plasma membrane;other membranes;mitochondrion;other cell component","transporter activity;other molecular function","NDUFS7","ENSG00000115286","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",2690,2824.2,2832.7,2800.9,2771.1,5203.5,0.774618347176465,-0.36844242224944174,0.3726634989022833,0.42868314280192016,0.5704287986338824,0.24379855683771237,4775]
["O75306-1","NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [OS=Homo sapiens]",47,17,73,17,463,52.5,7.55,235.08,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion;nucleus","transporter activity;other molecular function","NDUFS2","ENSG00000158864","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",7438.2,7553.2,7916.4,7397.9,6906.8,7210.3,1.0647362305368346,0.09049607267794331,0.08420898156918297,1.0746415850097344,0.2974787077279644,0.526544113791496,2069]
["O75312","Zinc finger protein ZPR1 [OS=Homo sapiens]",45,15,37,15,459,50.9,4.73,120.57,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ZPR1","ENSG00000109917","","","",3638.6,3575.3,3501.3,3652.9,4076.2,4109.1,0.9051376053791962,-0.143790957379916,0.06967507224982779,1.156922572271131,0.2711688514770987,0.5667601983172501,1878]
["O75323-1","Protein NipSnap homolog 2 [OS=Homo sapiens]",24,6,16,5,286,33.7,9.36,44.31,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;mitochondrion","","NIPSNAP2","ENSG00000146729","","RHOJ GTPase cycle; RHOH GTPase cycle","",1495.2,1435.9,1462.4,1410.5,1400.6,1710.6,0.9716478315677731,-0.041494583230691266,0.6999436959669769,0.15493689357762183,0.7963711821019045,0.09888446396427338,6424]
["O75330-1","Hyaluronan mediated motility receptor [OS=Homo sapiens]",36,25,38,24,724,84,5.83,108.57,"","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","HMMR","ENSG00000072571","ECM-receptor interaction","AURKA Activation by TPX2; Hyaluronan uptake and degradation","",4017,3788.6,3921.9,3954.1,4134.7,4218.1,0.9529207192713031,-0.06957190454226253,0.13197095733949035,0.8795216328469319,0.36717766547176817,0.43512374374902923,2627]
["O75335-1","Isoform 1 of Liprin-alpha-4 [OS=Homo sapiens]",1,1,1,1,701,78,7.28,2.27,"","","","PPFIA4","","","","",191.1,171.2,228.7,176.2,171,354.6,0.8421202621829582,-0.24790181733727168,0.5872730340843861,0.2311599402726871,0.7157543115095512,0.14523602722649354,5997]
["O75340","programmed cell death protein 6 [OS=Homo sapiens]",40,6,30,6,191,21.9,5.4,63.06,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PDCD6","ENSG00000249915","","","Epithelial to mesenchymal transition in colorectal cancer",4686.9,4361.7,4405.1,4434.6,4718.8,5267,0.9329630246040331,-0.10010818988477344,0.29038219151646566,0.5370300214543248,0.5221164668619551,0.2822326095004388,4065]
["O75347","Tubulin-specific chaperone A [OS=Homo sapiens]",34,5,6,5,108,12.8,5.29,13.87,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","TBCA","ENSG00000171530","","Post-chaperonin tubulin folding pathway","VEGFA-VEGFR2 signaling pathway",705.1,682.9,825.2,662.4,642.2,1172.1,0.8936084305729397,-0.16228529817938625,0.6491886704385708,0.1876290680339537,0.7590657482379641,0.119720605052784,6251]
["O75348","V-type proton ATPase subunit G 1 [OS=Homo sapiens]",7,1,1,1,118,13.7,8.79,1.8,"transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle","transporter activity;other molecular function","ATP6V1G1","ENSG00000136888","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis","Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Osteoclast signaling; Proximal tubule transport",150.9,158.9,183.2,155.7,174,213.7,0.9072506440927495,-0.14042691895670087,0.4414405987080703,0.3551277278484099,0.6114249262757789,0.21365686014156066,5277]
["O75351","Vacuolar protein sorting-associated protein 4B [OS=Homo sapiens]",58,20,82,16,444,49.3,7.23,209.91,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","VPS4B","ENSG00000119541","Endocytosis; Necroptosis","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)","",8744.4,8803,8749.1,9435,9482.8,7210.3,1.0064451682288418,0.009268575459298808,0.9439243221154558,0.025062823292119615,0.9627606573181505,0.01648166523823845,7166]
["O75352","Mannose-P-dolichol utilization defect 1 protein [OS=Homo sapiens]",10,2,24,2,247,26.6,8.94,56.6,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","","MPDU1","ENSG00000129255","","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective MPDU1 causes CDG-1f","",1632.9,1717.9,1654.8,1346.7,1400.8,1769.4,{"$f":"AVERAGE(S578:U578)/AVERAGE(V578:X578)","v":1.1081936726515975},{"$f":"LOG(Y578,2)","v":0.14821003495849247},{"$f":"TTEST(V578:X578,S578:U578,2,2)","v":0.2947418630528927},0.5305581756476556,{"$f":"AA578*7309/AE578","v":0.5253031643632267},0.27958998305116733,4101]
["O75354-1","Ectonucleoside triphosphate diphosphohydrolase 6 [OS=Homo sapiens]",2,1,2,1,484,53.2,9.26,6.59,"other metabolic processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","ENTPD6","ENSG00000197586","Purine metabolism; Pyrimidine metabolism; Metabolic pathways","Phosphate bond hydrolysis by NTPDase proteins","",98.8,86.6,97.8,107.4,101.6,173.9,0.7396186993993209,-0.4351463947671634,0.23055508368030483,{"$f":"-LOG10(AA579)","v":0.6372252972573557},0.47044307834152654,{"$f":"-LOG10(AC579)","v":0.3274929168863954},3582]
["O75362","zinc finger protein 217 [OS=Homo sapiens]",5,5,5,4,1048,115.2,8.48,14.96,"other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","ZNF217","ENSG00000171940","","Estrogen-dependent gene expression","",215.1,223.9,214.2,679.9,793.7,323,0.3635756428809975,-1.4596725429676558,0.05480881217837619,1.2611496098958093,0.24411798184750247,0.6124002290649294,1641]
["O75367-1","Core histone macro-H2A.1 [OS=Homo sapiens]",48,16,177,16,372,39.6,9.79,596.35,"cell organization and biogenesis;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","H2afy; H2AFY; LOC100466888; LOC101338325; LOC101381952; LOC101564704; LOC102987354; LOC103079324; LOC103663804; LOC106989149; LOC109250833; LOC110591142; LOC111141291; LOC111182462; LOC112404331; LOC112815157; LOC112861289; LOC112917035; LOC113261754; LOC113928700; LOC115516119; LOC116529369; MACROH2A1","ENSAMEG00000017887; ENSCAFG00000001076; ENSCANG00000022762; ENSCJAG00000005818; ENSFCAG00000013924; ENSG00000113648; ENSGGOG00000001707; ENSLCNG00005003680; ENSMLEG00000037795; ENSMNEG00000031666; ENSMPUG00000010011; ENSPCOG00000013464; ENSPCTG00005011747; ENSPPAG00000029258; ENSPTRG00000017256; ENSRBIG00000034425; ENSRROG00000045755; ENSSBOG00000034640; ENSSSUG00005001976; ENSVVUG00000017487","Necroptosis; Neutrophil extracellular trap formation; Alcoholism; Systemic lupus erythematosus","","H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma",28777.8,29396.5,27953.1,24213.7,25486.6,17375.4,1.2840328166534227,0.36068207459272705,0.06766582187291056,1.169630638849162,0.2687877674288605,0.5705904999747256,1840]
["O75368","SH3 domain-binding glutamic acid-rich-like protein [OS=Homo sapiens]",29,5,14,5,114,12.8,5.25,36.43,"","nucleus;other cell component","other molecular function","SH3BGRL","ENSG00000131171","","","",2602.6,2613.5,2651.9,2685.8,2709.4,3673.7,0.8675804121778825,-0.20493061399893703,0.2865160581222263,0.5428510324804051,0.5192526329817386,0.2846212926040508,4033]
["O75369-1","Filamin-B [OS=Homo sapiens]",14,31,65,20,2602,278,5.73,163.33,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","FLNB","ENSG00000136068","MAPK signaling pathway; Focal adhesion; Salmonella infection; Proteoglycans in cancer","ISG15 antiviral mechanism","Focal adhesion; MAPK signaling pathway; VEGFA-VEGFR2 signaling pathway; Ebola virus pathway in host",1826.2,1817.2,1840.4,1703.7,1659.4,6930.7,0.5327284384775303,-0.9085277969892572,0.41135104975237446,0.3857873900532241,0.5931278008759331,0.2268517193926529,5069]
["O75376-1","Nuclear receptor corepressor 1 [OS=Homo sapiens]",8,21,29,21,2440,270,7.11,79.66,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","NCOR1","ENSG00000141027","Endocrine resistance; Thyroid hormone signaling pathway; Transcriptional misregulation in cancer","HDACs deacetylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Transcriptional activation of mitochondrial biogenesis; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Nuclear Receptor transcription pathway; Cytoprotection by HMOX1; Nuclear signaling by ERBB4; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NR1D1 (REV-ERBA) represses gene expression; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis","Androgen receptor signaling pathway; Adipogenesis; Ovarian infertility; MECP2 and associated Rett syndrome; Pathways affected in adenoid cystic carcinoma; Rett syndrome causing genes; 22q11.2 copy number variation syndrome; Notch signaling pathway (Netpath)",3188.3,3047.2,3280.8,3943.6,3983.5,6022,0.6822160569499107,-0.5516993836044835,0.0987885684736469,1.0052933078015538,0.3223418066847702,0.49168336425174364,2240]
["O75379-1","Vesicle-associated membrane protein 4 [OS=Homo sapiens]",32,3,4,3,141,16.4,7.34,8.97,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","VAMP4","ENSCATG00000035773; ENSG00000117533; ENSGGOG00000023200; ENSMFAG00000031870; ENSMLEG00000033096; ENSMMUG00000023203; ENSMNEG00000025169; ENSNLEG00000015204; ENSPANG00000022546; ENSPPAG00000028975; ENSPTRG00000001680; ENSRBIG00000031656; ENSRROG00000036404","SNARE interactions in vesicular transport","Retrograde transport at the Trans-Golgi-Network; Cargo recognition for clathrin-mediated endocytosis","",145.8,131.4,123.7,160.8,199,176,0.7482269503546101,-0.41845216369160815,0.024939150873061464,1.6031183374421483,0.1667705889581027,0.777880537507878,1093]
["O75380","NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [OS=Homo sapiens]",29,3,4,3,124,13.7,8.28,14.58,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity;other molecular function","NDUFS6","ENSG00000145494","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",98.8,100.8,90.5,120.1,111.9,121.9,0.8197230856174061,-0.2867914662272329,0.00848251014722544,2.0714756121565987,0.1024771349852409,0.9893730249250948,605]
["O75381-1","Peroxisomal membrane protein PEX14 [OS=Homo sapiens]",41,12,27,12,377,41.2,4.94,82.63,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","PEX14","ENSG00000142655; ENSMFAG00000032533; ENSMMUG00000019979; ENSPANG00000017539; ENSPPAG00000038193; ENSPTRG00000000132","Peroxisome","Peroxisomal protein import; E3 ubiquitin ligases ubiquitinate target proteins; Class I peroxisomal membrane protein import","",2857.6,2832.9,2821.7,3134.3,3222.8,3408.4,0.8716604372535969,-0.198161864584072,0.006844823003682324,2.164637777554524,0.09386268542948238,1.027507024697123,533]
["O75385","Serine/threonine-protein kinase ULK1 [OS=Homo sapiens]",2,2,2,2,1050,112.6,8.79,1.95,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","ULK1","ENSG00000177169","Mitophagy; Autophagy; mTOR signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration","RAB GEFs exchange GTP for GDP on RABs; Macroautophagy; TBC/RABGAPs; Receptor Mediated Mitophagy","Target of rapamycin (TOR) signaling; Alzheimer's disease and miRNA effects; Nanoparticle triggered autophagic cell death; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; 7q11.23 copy number variation syndrome; p53 transcriptional gene network; Malignant pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; Senescence and autophagy in cancer",272.5,252,276,242.8,233.8,384.4,0.9297328687572589,-0.10511183488058717,0.7036766185343082,0.15262687928414448,0.7993740138121322,0.0972499739661225,6434]
["O75386","Tubby-related protein 3 [OS=Homo sapiens]",2,1,2,1,442,49.6,7.74,4.86,"developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","TULP3","ENSG00000078246","","Hedgehog 'off' state","H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Genes related to primary cilium development (based on CRISPR)",277.3,242.8,257.7,268.5,277.5,169.8,1.086616373288628,0.11984269101782405,0.5958235239046741,0.2248823542590861,0.7208862996555642,0.1421332281045795,6041]
["O75390","citrate synthase, mitochondrial [OS=Homo sapiens]",41,17,151,17,466,51.7,8.32,428.26,"other metabolic processes","mitochondrion","other molecular function","CS","ENSG00000062485","Citrate cycle (TCA cycle); Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids","Citric acid cycle (TCA cycle); Mitochondrial protein import","TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Fluoroacetic acid toxicity; TCA cycle (aka Krebs or citric acid cycle)",20864.9,20980.3,20026.1,19051.1,18924.2,21812.9,1.0348413232042442,0.04940956987312932,0.5214328001755418,0.2828016534760853,0.6696806073595213,0.1741322772004373,5691]
["O75396","Vesicle-trafficking protein SEC22b [OS=Homo sapiens]",38,7,51,7,215,24.6,6.92,195.73,"","","","","","","","",4601,4639.9,4672.6,4298,4549.9,4692.3,1.0275697552473373,0.03923633272308956,0.3479267051988525,0.4585122355944985,0.5579193260856544,0.2534285945548823,4558]
["O75398","Deformed epidermal autoregulatory factor 1 homolog [OS=Homo sapiens]",1,1,1,1,565,59.3,5.34,2.35,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;nucleus;other cell component","nucleic acid binding activity;other molecular function","DEAF1","ENSG00000177030","","","Sudden infant death syndrome (SIDS) susceptibility pathways",67,53.3,67.9,75.4,76.4,45.1,0.9558151345860841,-0.06519648317301718,0.8101994620390385,0.09140804951771647,0.8716143461941908,0.05967563016775267,6794]
["O75400","pre-mRNA-processing factor 40 homolog A [OS=Homo sapiens]",30,24,56,1,957,108.7,7.56,145.1,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","","PRPF40A","ENSG00000196504","Spliceosome","mRNA Splicing - Major Pathway","mRNA processing",89.6,105.1,119.2,106.6,107.9,152,0.8564802182810367,-0.22350816943905924,0.3655708342534963,0.4370284601702359,0.5669334240523667,0.24646793804589873,4713]
["O75400-3","Isoform 3 of Pre-mRNA-processing factor 40 homolog A [OS=Homo sapiens]",29,24,60,1,939,106.8,7.43,150.08,"","","","PRPF40A","","","","",8049.3,8208.8,8231.8,8218.2,7747.9,4604.7,1.1905176269274893,0.25158898145882436,0.31412902799257547,0.5028919295215865,0.5382018437875608,0.26905481875102344,4266]
["O75410-1","Transforming acidic coiled-coil-containing protein 1 [OS=Homo sapiens]",52,30,97,27,805,87.7,4.88,317.53,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","TACC1","ENSG00000147526","","","",9185.5,8650.2,8967.9,9714.8,10183.4,9163,0.9223156648727513,-0.11666749368468739,0.0869171169758022,1.0608946875777638,0.30265707859749325,0.5190491642761913,2099]
["O75414","Nucleoside diphosphate kinase 6 [OS=Homo sapiens]",17,3,7,3,186,21.1,8.32,21.18,"other metabolic processes;other biological processes","mitochondrion","kinase activity;other molecular function","NME6","ENSG00000172113","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors","","Pyrimidine metabolism",557.5,585.7,640,571.2,530.7,2026,0.570094951884651,-0.8107258682334803,0.4141711031530916,0.38282020524687865,0.594379853317484,0.22593591953908393,5093]
["O75419","Cell division control protein 45 homolog [OS=Homo sapiens]",3,2,2,2,566,65.5,5.53,4.77,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","CDC45","ENSG00000093009","Cell cycle","Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA; G1/S-Specific Transcription","Cell cycle; Retinoblastoma gene in cancer; G1 to S cell cycle control; 22q11.2 copy number variation syndrome; DNA replication",178.7,190.3,191.8,218.6,205.9,347.2,0.7267072696643773,-0.4605537563974396,0.19581404020076665,0.708156171761129,0.4364760048268995,0.3600396265465212,3279]
["O75420","GRB10-interacting GYF protein 1 [OS=Homo sapiens]",8,6,8,6,1035,114.5,5.39,22.65,"signal transduction","cytosol;other cell component","","GIGYF1","ENSG00000146830","","","",274.1,296.6,271.3,366.4,385.5,676.8,0.5893469587737105,-0.7628108711365646,0.12422871789456467,0.9057779969013521,0.35677316270780873,0.44760782169015667,2545]
["O75427","Leucine-rich repeat and calponin homology domain-containing protein 4 [OS=Homo sapiens]",29,13,29,13,683,73.4,8.22,97.56,"developmental processes","nucleus","","LRCH4","ENSG00000077454","","","",1637.4,1684.5,1697.5,1491.8,1598.6,1369.7,1.1254007757673596,0.1704388629948119,0.053115349470472535,1.2747799567523657,0.2417310643086449,0.6166675358110549,1606]
["O75431","Metaxin-2 [OS=Homo sapiens]",39,7,29,7,263,29.7,6.29,115.23,"cell organization and biogenesis;transport","other membranes;mitochondrion;nucleus;other cell component","","MTX2","ENSG00000128654","","Mitochondrial protein import; Cristae formation","",1530,1603.3,1578.4,1666.1,1478.8,2193.3,0.8826383425124575,-0.18010567439074981,0.3863449634851948,0.4130247449819011,0.5788838331515558,0.23740857907563995,4878]
["O75436-1","Vacuolar protein sorting-associated protein 26A [OS=Homo sapiens]",51,14,42,12,327,38.1,6.57,115.45,"transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","VPS26A","ENSANAG00000022406; ENSCATG00000037809; ENSCCAG00000021117; ENSCJAG00000012907; ENSCSAG00000007798; ENSG00000122958; ENSMFAG00000042937; ENSMMUG00000004101; ENSMNEG00000039163; ENSNLEG00000011548; ENSPANG00000022152; ENSPPAG00000041182; ENSPPYG00000002386; ENSPTRG00000002567; ENSRBIG00000023684; ENSRROG00000006745; ENSSBOG00000030031","Endocytosis","WNT ligand biogenesis and trafficking","",3806.8,4011.7,4328,3823.6,3271.8,3597.8,1.1359088018553847,0.18384701055339994,0.09299933871374573,1.0315201395535085,0.31266429009142943,0.5049217174198112,2174]
["O75438","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [OS=Homo sapiens]",19,1,3,1,58,7,8.92,7.18,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB1","ENSG00000183648","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",317.5,200.9,242.9,266.8,521.1,816.7,0.47444846067555774,-1.0756767190556393,0.15872803420207418,0.7993463623186727,0.39663015452408895,0.401614270852899,2925]
["O75439","mitochondrial-processing peptidase subunit beta [OS=Homo sapiens]",42,17,69,16,489,54.3,6.83,218.05,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport","other membranes;mitochondrion","other molecular function","PMPCB","ENSG00000105819","","Mitochondrial protein import; Processing of SMDT1","",6760.8,6666,7204.3,6338.3,5830.4,6872,1.0835263409433475,0.11573422633090821,0.19756626546489023,0.7042872094102607,0.43824334879601906,0.3582846664563164,3295]
["O75448","Mediator of RNA polymerase II transcription subunit 24 [OS=Homo sapiens]",14,10,14,10,989,110.2,6.95,41.37,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","MED24","ENSG00000008838","Thyroid hormone signaling pathway","Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","",964.4,1015.7,973.1,891.1,956.1,840,1.0989877939863055,0.1361753629448176,0.07541777694923388,1.122526273215333,0.2826812983189489,0.548702922693878,1950]
["O75449-1","Katanin p60 ATPase-containing subunit A1 [OS=Homo sapiens]",15,8,11,7,491,55.9,6.9,16.05,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KATNA1","ENSG00000186625","","","",1332.2,1219.8,1420.3,1414.4,1283.5,1140.5,1.0348843268028345,0.04946952088976321,0.672703831881332,0.1721760984652905,0.7757640118682007,0.11027037143559923,6338]
["O75460","Serine/threonine-protein kinase/endoribonuclease IRE1 [OS=Homo sapiens]",22,15,31,15,977,109.7,6.42,111.1,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","ERN1","ENSG00000178607","Autophagy; Protein processing in endoplasmic reticulum; Apoptosis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Lipid and atherosclerosis","IRE1alpha activates chaperones","Alzheimer's disease and miRNA effects; Corticotropin-releasing hormone signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling pathway; Nonalcoholic fatty liver disease; Unfolded protein response; Alzheimer's disease",2107.4,2135,2069.7,2940.8,3198.4,4318.1,0.603607049620839,-0.728318439464063,0.030931459757030762,1.5095995837322327,0.18530986833126054,0.7321014525230081,1220]
["O75475-1","PC4 and SFRS1-interacting protein [OS=Homo sapiens]",51,28,82,27,530,60.1,9.13,247.61,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PSIP1","ENSG00000164985; ENSGGOG00000016152; ENSPTRG00000020786","","Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection","MECP2 and associated Rett syndrome",11771.2,11814.7,11594.6,11971.4,12573.7,10714.8,0.9977481501649185,-3.252395919417379E-3,0.9640379670431332,0.015905861789462742,0.9752461593243267,0.010885751334075246,7225]
["O75477","erlin-1 [OS=Homo sapiens]",27,10,23,7,346,38.9,7.87,65.26,"","","","","","","","",1799.7,1837.8,1890.5,1796.5,1707.4,2433.8,0.9310002189399935,-0.10314658782981775,0.5849992789503973,0.23284466921364286,0.7138163155005766,0.14641352971898128,5990]
["O75487","Glypican-4 [OS=Homo sapiens]",10,4,7,4,556,62.4,6.68,26.89,"cell adhesion;cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes","extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","GPC4","ENSG00000076716","Wnt signaling pathway","A tetrasaccharide linker sequence is required for GAG synthesis; HS-GAG biosynthesis; HS-GAG degradation; Defective B4GALT7 causes EDS, progeroid type; Defective B3GAT3 causes JDSSDHD; Defective EXT2 causes exostoses 2; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Defective B3GALT6 causes EDSP2 and SEMDJL1; Retinoid metabolism and transport","Wnt signaling",734.9,776.6,709.9,775.3,921.1,793.6,0.892128514056225,-0.16467654479027635,0.1466749324561714,0.8336441031042594,0.3835588841939737,0.41616795344272856,2795]
["O75489","NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [OS=Homo sapiens]",63,16,72,16,264,30.2,7.5,211.44,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion;nucleus","transporter activity;other molecular function","NDUFS3","ENSG00000213619; ENSG00000285387","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","RHOG GTPase cycle; Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",8435.2,8454.2,8158.9,8658.4,8690.6,6648.9,1.043770496585118,0.06180452815566318,0.6347197216275977,0.19741800734072243,0.7503099539667009,0.1247592919556248,6183]
["O75494-1","Serine/arginine-rich splicing factor 10 [OS=Homo sapiens]",30,10,43,10,262,31.3,11.27,118.09,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","Srsf10; SRSF10","ENSCATG00000031598; ENSCCAG00000022497; ENSCPOG00000034102; ENSG00000188529; ENSGGOG00000000392; ENSMLEG00000016013; ENSMNEG00000041500; ENSMUSG00000028676; ENSNLEG00000027520; ENSPANG00000021680; ENSPCOG00000022379; ENSPCTG00005007467; ENSPPAG00000032557; ENSPPYG00000001726; ENSPTRG00000044753; ENSRBIG00000028456; ENSRFEG00010001865; ENSRROG00000043248; ENSSBOG00000019550; ENSSSCG00070027414; ENSSTOG00000000956; ENSTSYG00000009439","Spliceosome","mRNA Splicing - Major Pathway; mRNA Splicing - Major Pathway","mRNA processing; mRNA processing; mRNA Processing",6968.5,7103,6786.5,6696.7,7399.6,7740.8,0.9551634603495887,-0.06618044733483805,0.3664680610482209,0.4359638696311661,0.5671215452469716,0.24632385332389303,4723]
["O75503","Ceroid-lipofuscinosis neuronal protein 5 [OS=Homo sapiens]",13,3,4,3,358,41.5,7.4,11.35,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CLN5","ENSG00000102805","Lysosome","","",125.3,106.2,115.7,90.4,99.1,128.5,1.0918238993710692,0.1267401822727616,0.4886530449569714,0.3109993906542715,0.6470226640562508,0.18908050649949742,5520]
["O75521","Enoyl-CoA delta isomerase 2, mitochondrial [OS=Homo sapiens]",48,13,45,13,394,43.6,9,154.73,"other metabolic processes","cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","ECI2","ENSG00000198721","Fatty acid degradation; Peroxisome","","",3865.4,3878.2,3878.4,3618.1,3693.1,3085.9,1.11781169749257,0.16067717747085125,0.09956781234645297,1.001881034865317,0.32286652193443865,0.490976984691432,2254]
["O75525-1","KH domain-containing, RNA-binding, signal transduction-associated protein 3 [OS=Homo sapiens]",9,4,17,2,346,38.8,7.61,34.39,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KHDRBS3","ENSCCAG00000031191; ENSG00000131773; ENSGGOG00000000940; ENSRBIG00000036854; ENSRROG00000044792","","PTK6 Regulates Proteins Involved in RNA Processing","",98.5,90.4,91.7,126.9,130.9,228.7,0.5767728674203495,-0.7939247960485746,0.10894079485496651,0.962809460347387,0.3359697340063081,0.473699844473518,2370]
["O75530","Polycomb protein EED [OS=Homo sapiens]",20,7,11,7,441,50.2,7.03,34.57,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","EED","ENSG00000074266","","Transcriptional Regulation by E2F6; HCMV Early Events; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; PKMTs methylate histone lysines; PRC2 methylates histones and DNA; Defective pyroptosis","Histone modifications; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Malignant pleural mesothelioma",1116.9,1062.9,1174,1224,1058,1029.6,1.012743084913637,0.01826823422715101,0.8475125287818471,0.07185387289998055,0.8958017458953754,0.04778809546133695,6915]
["O75531","Barrier-to-autointegration factor [OS=Homo sapiens]",30,3,4,3,89,10.1,6.09,5.01,"cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","BANF1","ENSG00000175334","","Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Nuclear Envelope Breakdown; Initiation of Nuclear Envelope (NE) Reformation","Envelope proteins and their potential roles in EDMD physiopathology; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy",239.5,252.2,257.4,227.2,247.3,164.6,1.172117039586919,0.2291166346075421,0.2232917213412906,0.6511273783277759,0.46483599865664854,0.33270024590915415,3511]
["O75533-1","splicing factor 3B subunit 1 [OS=Homo sapiens]",49,53,229,53,1304,145.7,7.09,699.58,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","LOC101357717; LOC111145177; Sf3b1; SF3B1","ENSANAG00000021577; ENSCANG00000029415; ENSCATG00000035735; ENSCCAG00000020506; ENSCGRG00001016990; ENSCGRG00015028775; ENSCJAG00000003902; ENSCSAG00000011505; ENSDLEG00000016863; ENSFCAG00000005038; ENSG00000115524; ENSLAFG00000001956; ENSLCNG00005009987; ENSMMNG00015005194; ENSMMUG00000022430; ENSMNEG00000042333; ENSMPUG00000007799; ENSMUSG00000025982; ENSNLEG00000006861; ENSPANG00000013417; ENSPCTG00005000567; ENSPPAG00000035007; ENSRNOG00000013516; ENSRROG00000031308; ENSSBOG00000020080; ENSSSCG00000016075; ENSSSCG00070023758; ENSSSUG00005005995; ENSSTOG00000011034; ENSUMAG00000020945","Spliceosome","B-WICH complex positively regulates rRNA expression; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; mRNA Splicing - Major Pathway; B-WICH complex positively regulates rRNA expression; mRNA Splicing - Minor Pathway; mRNA Splicing - Major Pathway; B-WICH complex positively regulates rRNA expression; mRNA Splicing - Minor Pathway","mRNA processing; mRNA processing; mRNA processing",25794.3,25271.9,26415.2,30282.9,29921.9,30516.4,0.8540605723910175,-0.22758970140087234,2.9199421291204022E-4,3.5346257558299135,0.0251080670844012,1.600186719660233,85]
["O75534","cold shock domain-containing protein E1 [OS=Homo sapiens]",39,32,122,32,798,88.8,6.25,346.46,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","nucleic acid binding activity","CSDE1","ENSG00000009307","","","",18773.8,18786.5,18691.5,22128.8,21274.5,18451.9,0.9094110115236876,-0.13699562195243806,0.16812993599790144,0.7743549523475914,0.4089390023988891,0.3883414668023768,3005]
["O75554","WW domain-binding protein 4 [OS=Homo sapiens]",5,2,2,2,376,42.5,5.57,5.48,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","WBP4","ENSG00000120688","","mRNA Splicing - Major Pathway","",304,280.7,287.1,347.1,344.6,448.2,0.7648039301693131,-0.3868381578380401,0.06223007179517992,1.2059996979672813,0.2574078068766101,0.5893782855900725,1767]
["O75558","syntaxin-11 [OS=Homo sapiens]",5,1,4,1,287,33.2,6.55,17.41,"cell-cell signaling;cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","STX11","ENSG00000135604","SNARE interactions in vesicular transport","","",252.1,217.5,203.2,201.2,219,241.1,1.017389989414789,0.024872804018612953,0.8463316447294348,0.07245942035096603,0.895071334297126,0.04814235143596197,6911]
["O75569-1","Interferon-inducible double-stranded RNA-dependent protein kinase activator A [OS=Homo sapiens]",29,8,30,8,313,34.4,8.41,86.74,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;kinase activity;other molecular function","PRKRA","ENSCATG00000032736; ENSG00000180228; ENSMNEG00000031681; ENSPANG00000001046; ENSPTRG00000012688","","MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis","VEGFA-VEGFR2 signaling pathway; Ebola virus pathway in host",3736.5,3766.6,3739.4,3353.5,3310.7,3951.7,1.0590246705413577,0.08273619806783356,0.3703050748211919,0.43144033615002225,0.5687244782240158,0.24509807906480682,4759]
["O75570","Peptide chain release factor 1, mitochondrial [OS=Homo sapiens]",6,2,3,2,445,52.3,8.5,7.44,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","mitochondrion","nucleic acid binding activity","MTRF1","ENSG00000120662","","","",188.6,193.6,209.8,159,187.2,79.5,1.3906506929762743,0.4757600857346045,0.16702052658169572,0.7772301514072325,0.4071891356856618,0.3902038180355202,2998]
["O75582-1","Ribosomal protein S6 kinase alpha-5 [OS=Homo sapiens]",3,2,2,2,802,89.8,7.11,4.81,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","kinase activity;other molecular function","RPS6KA5","ENSG00000100784; ENSGGOG00000004254; ENSPPAG00000038077; ENSPTRG00000006631","MAPK signaling pathway; Adrenergic signaling in cardiomyocytes; TNF signaling pathway; Circadian entrainment; Neurotrophin signaling pathway; Shigellosis; Pathways in cancer; MicroRNAs in cancer; Bladder cancer","Recycling pathway of L1; NCAM signaling for neurite out-growth; ERK/MAPK targets; CREB phosphorylation; CD209 (DC-SIGN) signaling","Brain-derived neurotrophic factor (BDNF) signaling pathway; Interleukin-1 (IL-1) structural pathway; Bladder cancer; MAPK signaling pathway; ERK pathway in Huntington's disease; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; p38 MAPK signaling pathway; EGF/EGFR signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Insulin signaling; Malignant pleural mesothelioma; Interferon type I signaling pathways; Serotonin receptor 4/6/7 and NR3C signaling; EGFR1 signaling pathway; MAPK signaling pathway; p38 MAPK signaling pathway",99.7,108.1,89.1,96.9,107.3,78.4,1.0506015569709835,0.07121562765271575,0.6609978638314613,0.17979994403585425,0.7678374740534251,0.11473069610313054,6292]
["O75586","Mediator of RNA polymerase II transcription subunit 6 [OS=Homo sapiens]",13,4,4,4,246,28.4,8.62,8.85,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MED6","ENSG00000133997","","Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","",718.1,729.3,744.3,761.2,780.3,433.3,1.1098339072311119,0.15034378545517715,0.5566752294592119,0.254398103191928,0.6929051859872922,0.15932618821596917,5872]
["O75592-1","E3 ubiquitin-protein ligase MYCBP2 [OS=Homo sapiens]",18,71,138,1,4640,509.8,7.03,376.42,"","","","","","","","",88.2,97.1,95,92.7,85.7,60.1,1.1752620545073376,0.23298247813962006,0.24623281389565999,0.6086540718587672,0.4830154688039127,0.316038960535018,3726]
["O75592-2","Isoform 2 of E3 ubiquitin-protein ligase MYCBP2 [OS=Homo sapiens]",18,71,138,1,4637,509.4,7.03,374.77,"","","","","","","","",14130.1,14076.8,14088.1,14164.2,14023.6,17951.4,0.91668256059923,-0.12550586764869412,0.3756316316282169,0.42523784328781516,0.5719774157438828,0.24262111877942935,4800]
["O75607","Nucleoplasmin-3 [OS=Homo sapiens]",44,5,34,5,178,19.3,4.63,111.29,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","NPM3","ENSG00000107833","","","",2498.4,2455.6,2507.9,2851.6,2587.8,2784.3,0.907365297858628,-0.14024460994480673,0.03469951485143861,1.4596765972211156,0.19315975175107752,0.7140833614266221,1313]
["O75608","Acyl-protein thioesterase 1 [OS=Homo sapiens]",49,8,37,8,230,24.7,6.77,117.04,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","LYPLA1","ENSG00000120992","Glycerophospholipid metabolism; Choline metabolism in cancer","RAS processing; eNOS activation","",4833.3,4864.9,4723.6,4325.1,4437.5,4005.5,1.129518095879575,0.17570738416755766,0.015549278215231933,1.8082897657636534,0.13465601241129171,0.8707742505053354,844]
["O75616-1","GTPase Era, mitochondrial [OS=Homo sapiens]",24,7,15,7,437,48.3,8.84,51.11,"cell organization and biogenesis","other membranes;cytosol;mitochondrion","translation activity;nucleic acid binding activity;other molecular function","ERAL1","ENSG00000132591","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Integrated breast cancer pathway",1261.7,1269.3,1326.6,1177.6,1257.3,1558,0.9661148538656116,-0.049733384860871886,0.7209078451888066,0.14212024829573372,0.8113821127941158,0.09077457070174338,6494]
["O75626-1","PR domain zinc finger protein 1 [OS=Homo sapiens]",5,4,9,3,825,91.7,8.48,18.45,"cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","PRDM1","ENSG00000057657","","STAT3 nuclear events downstream of ALK signaling; Regulation of TP53 Expression","Nucleotide-binding oligomerization domain (NOD) pathway; Vitamin D receptor pathway; IL-6 signaling pathway; Overview of leukocyte-intrinsic Hippo pathway functions",261.6,274.6,262.8,561.4,636.4,576.9,0.4502169380740407,-1.1513077599617085,1.5104171079825219E-4,3.8209031039117853,0.02044377526341528,1.6894389018507807,54]
["O75643-1","U5 small nuclear ribonucleoprotein 200 kDa helicase [OS=Homo sapiens]",42,80,293,79,2136,244.4,6.06,888.7,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","SNRNP200","ENSCATG00000015790; ENSG00000144028; ENSGGOG00000005174; ENSMLEG00000019083; ENSPPAG00000041559; ENSPPYG00000012068; ENSPTRG00000012230; ENSRBIG00000044690; ENSRROG00000037952","Spliceosome","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","",34222.5,33731.9,34857.4,35500,35005.1,29160.1,1.0315717020584916,0.04484410295880926,0.6377183338635045,0.1953710972337011,0.752515870553496,0.12348433637049613,6194]
["O75648-1","Mitochondrial tRNA-specific 2-thiouridylase 1 [OS=Homo sapiens]",33,12,22,12,421,47.7,8.03,61.55,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","nucleic acid binding activity;other molecular function","TRMU","ENSG00000100416","","tRNA modification in the mitochondrion","",1739,1791.8,1885.4,1629.2,1459.8,1880,1.0899979875226407,0.12432547133817734,0.3133178290175432,0.504014891349933,0.537568078002165,0.2695665285686791,4260]
["O75663","TIP41-like protein [OS=Homo sapiens]",33,9,38,9,272,31.4,5.91,107.7,"stress response;signal transduction;other biological processes","cytosol","","TIPRL","ENSG00000143155","","","Ciliary landscape",5278.8,5480.3,5109.6,5484.6,5165.1,4674,1.0355658228756761,0.05041925739062373,0.5216275009603465,0.2826395200359517,0.6696953108236734,0.1741227419635263,5693]
["O75665","Oral-facial-digital syndrome 1 protein [OS=Homo sapiens]",4,4,4,4,1012,116.6,6.1,14.19,"cell organization and biogenesis;transport;developmental processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","OFD1","ENSG00000046651","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Hedgehog 'off' state","Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies",282.7,270.9,316.9,387.9,309.6,310.8,0.8633343251016562,-0.21200874549069462,0.19258477621751235,0.7153780467340394,0.43364206080523654,0.3628686003402795,3246]
["O75674","TOM1-like protein 1 [OS=Homo sapiens]",5,1,2,1,476,53,5.24,10.18,"protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","TOM1L1","ENSG00000141198","","","",44.1,48,51.5,43.3,65.3,97.7,0.696073679108095,-0.5226880720634333,0.2600841010964211,0.5848861953517367,0.49620326152799316,0.3043403854508415,3831]
["O75676","Ribosomal protein S6 kinase alpha-4 [OS=Homo sapiens]",9,7,8,7,772,85.6,8.28,21.95,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","RPS6KA4","ENSG00000162302","MAPK signaling pathway; TNF signaling pathway","Recycling pathway of L1","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Translation inhibitors in chronically activated PDGFRA cells; Insulin signaling; Interferon type I signaling pathways",707.6,732,716.2,628.6,711.3,819,0.9985640835610728,-2.0730782656065727E-3,0.9860577967572626,0.00609762859113404,0.9898498058644186,0.004430697758758266,7281]
["O75683","Surfeit locus protein 6 [OS=Homo sapiens]",17,3,6,3,361,41.4,10.64,16.61,"other biological processes","nucleus;other cell component","nucleic acid binding activity","SURF6","ENSG00000148296; ENSG00000281309","","","",49.8,41.7,52.1,107.4,111.5,148,0.39138729899155084,-1.3533311554254914,0.004982053798760754,2.302591587040625,0.07797394264484443,1.108050505722764,467]
["O75688","Protein phosphatase 1B [OS=Homo sapiens]",30,12,32,1,479,52.6,5.05,85.91,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;nucleus","other molecular function","PPM1B","ENSG00000138032","MAPK signaling pathway","ISG15 antiviral mechanism; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants","MAPK signaling pathway",2649.4,2727.6,2638.9,2757.5,2841.6,2556.3,0.9828947691100375,-0.024891128178770136,0.6294840352326162,0.20101527985047976,0.7467779278550872,0.12680852675991633,6161]
["O75688-2","Isoform Beta-2 of Protein phosphatase 1B [OS=Homo sapiens]",36,12,32,1,387,42.7,5.2,78.89,"","","","PPM1B","","","","",177.7,197.6,180,193.8,197.4,280.3,0.8269545793000744,-0.2741200037230745,0.25181978566545465,0.5989101500512405,0.4884688995299385,0.3111630822881072,3768]
["O75691","Small subunit processome component 20 homolog [OS=Homo sapiens]",11,23,31,23,2785,318.2,7.39,92.85,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;nucleus;other cell component","","UTP20","ENSG00000120800","","rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol","",2715.7,2876.4,2840.2,5034.3,5337.5,4439.7,0.5693076325827903,-0.8127196531320849,1.3687088913081626E-3,2.863688911502476,0.04387672494110246,1.357765796618957,228]
["O75694","nuclear pore complex protein nup155 [OS=Homo sapiens]",25,26,67,26,1391,155.1,6.16,198.87,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus","other molecular function","NUP155","ENSG00000113569","Nucleocytoplasmic transport; Amyotrophic lateral sclerosis","HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation","",5991.2,6013.5,6260,5660,5298.9,4918.9,1.1503293907216368,0.2020470284019477,0.02606340666647286,1.5839688196381518,0.1702389985033513,0.768940944282529,1119]
["O75695","Protein XRP2 [OS=Homo sapiens]",31,9,25,9,350,39.6,5.12,60.43,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","RP2","ENSG00000102218","","Trafficking of myristoylated proteins to the cilium","Joubert syndrome; Ciliopathies",2611,2777.2,2584,2028.4,2125.4,2211,{"$f":"AVERAGE(S642:U642)/AVERAGE(V642:X642)","v":1.2525452488687783},{"$f":"LOG(Y642,2)","v":0.32486272249388476},{"$f":"TTEST(V642:X642,S642:U642,2,2)","v":2.6089293778906496E-3},2.583537676824466,{"$f":"AA642*7309/AE642","v":0.05831395970337235},1.234227467600779,327]
["O75717","WD repeat and HMG-box DNA-binding protein 1 [OS=Homo sapiens]",16,12,13,12,1129,125.9,5.62,27.54,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response","nucleus;other cell component","nucleic acid binding activity;other molecular function","WDHD1","ENSG00000198554","","","Mesodermal commitment pathway",1208.4,1284,1343.7,1235.9,1365.9,1920.1,0.8483380879718703,-0.23728875859596255,0.3444097251889563,{"$f":"-LOG10(AA643)","v":0.4629245937565152},0.5552030616246321,{"$f":"-LOG10(AC643)","v":0.25554814766304074},4534]
["O75718","Cartilage-associated protein [OS=Homo sapiens]",17,6,7,6,401,46.5,5.73,22.1,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;ER/Golgi;other cell component","","CRTAP","ENSG00000170275","","Collagen biosynthesis and modifying enzymes","Type I collagen synthesis in the context of osteogenesis imperfecta",418.4,423.7,448.3,425.9,421.3,758.5,0.8036370430341906,-0.3153840293601746,0.401250101524709,0.39658484470142585,0.5871345329417614,0.23126237537945396,4995]
["O75746","Calcium-binding mitochondrial carrier protein Aralar1 [OS=Homo sapiens]",27,17,28,12,678,74.7,8.38,83.01,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","SLC25A12","ENSG00000115840","","Mitochondrial protein import; Gluconeogenesis; Aspartate and asparagine metabolism","",3761,3769.7,3931.3,3441.1,3498,5925.1,0.8909998289827583,-0.1665029400489756,0.5994027360618428,0.22228127898488775,0.723898644725051,0.1403222364520639,6052]
["O75787","Renin receptor [OS=Homo sapiens]",12,3,6,3,350,39,6.1,20.4,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ATP6AP2","ENSG00000182220","Renin-angiotensin system","Neutrophil degranulation; Metabolism of Angiotensinogen to Angiotensins","ACE inhibitor pathway; Oxidative phosphorylation",238.7,249.7,245.7,217.2,219.8,699.8,0.6457600281491906,-0.6309299524422346,0.44992773498701155,0.34685723470605734,0.617562782163393,0.2093188849328597,5325]
["O75792","Ribonuclease H2 subunit A [OS=Homo sapiens]",25,7,14,7,299,33.4,5.25,47.15,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RNASEH2A","ENSG00000104889","DNA replication","","",1187.5,1189.2,1136.3,1261.8,1300.3,1489,0.8671718792426749,-0.2056101213308766,0.06818755279537606,1.166294895807541,0.26925057989270856,0.5698433526764721,1851]
["O75794","Cell division cycle protein 123 homolog [OS=Homo sapiens]",24,6,16,6,336,39.1,4.81,41.87,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","other cell component","","CDC123","ENSG00000151465","","","",799.9,816.9,824.2,1634.7,1621,1726.7,0.4899245343609505,-1.0293685544105209,1.5328105568454138E-5,4.81451151716172,0.01120331235998313,1.950653555277747,10]
["O75795","UDP-glucuronosyltransferase 2B17 [OS=Homo sapiens]",11,6,14,6,530,61.1,8.54,31.24,"other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","UGT2B17","ENSG00000197888","Pentose and glucuronate interconversions; Ascorbate and aldarate metabolism; Steroid hormone biosynthesis; Retinol metabolism; Porphyrin and chlorophyll metabolism; Metabolism of xenobiotics by cytochrome P450; Drug metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors; Bile secretion; Chemical carcinogenesis; Chemical carcinogenesis","Glucuronidation","Glucuronidation; Metapathway biotransformation Phase I and II",1063.3,1092.1,1095.8,1013,962.9,3682.9,0.5745387714709833,-0.7995238416651733,0.42223182073223475,0.37444903998226275,0.5994740438484661,0.22222961633063887,5148]
["O75808-1","Calpain-15 [OS=Homo sapiens]",5,3,3,3,1086,117.2,6.71,12.14,"protein metabolism","other cell component","other molecular function","CAPN15","ENSG00000103326","","Degradation of the extracellular matrix","",110.3,111.8,134.7,138.4,142.6,210.4,0.7260887260887261,-0.46178224244186006,0.14262167073949628,0.8458144803219586,0.3781000331646639,0.4223932845437593,2757]
["O75817","Ribonuclease P protein subunit p20 [OS=Homo sapiens]",11,1,3,1,140,15.6,8.94,12.21,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POP7","ENSG00000172336","Ribosome biogenesis in eukaryotes","tRNA processing in the nucleus","",262.6,258,244.7,335.9,323.8,584.1,0.6152918475639169,-0.7006572175069429,0.13379723628074977,0.8735528572738475,0.3688887212282158,0.4331046231229679,2651]
["O75818-1","Ribonuclease P protein subunit p40 [OS=Homo sapiens]",8,2,3,2,363,41.8,6.67,14.23,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RPP40","ENSG00000124787","Ribosome biogenesis in eukaryotes","tRNA processing in the nucleus; Major pathway of rRNA processing in the nucleolus and cytosol","",474,429.8,461.3,446.8,487,501,0.9514218009478672,-0.07184301118987078,0.328446582554528,0.4835352525522954,0.545966811892437,0.26283375628802863,4397]
["O75820-1","Zinc finger protein 189 [OS=Homo sapiens]",7,3,6,1,626,72.9,8.5,8.26,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF189","ENSG00000136870; ENSGGOG00000003650; ENSPPAG00000034345; ENSPPYG00000019452; ENSPTRG00000021200","Herpes simplex virus 1 infection","Generic Transcription Pathway","",14.9,16.2,17.1,18.5,15.2,19.3,0.9094339622641509,-0.13695921322060006,0.31924040039444185,0.4958821531668299,0.5407481081072943,0.2670049913340854,4315]
["O75821","Eukaryotic translation initiation factor 3 subunit G [OS=Homo sapiens]",57,20,77,20,320,35.6,6.13,246.58,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity","EIF3G","ENSG00000130811","","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell",8792.4,9107.9,9014.5,10523.9,10441.8,9435.6,0.8853174041899526,-0.17573331160736796,0.032626490190783355,1.4864296431217332,0.1888099895522055,0.723975031793091,1263]
["O75822","Eukaryotic translation initiation factor 3 subunit J [OS=Homo sapiens]",32,9,27,9,258,29,4.83,70.19,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3J","ENSG00000104131","","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell",5051.9,2530.4,5256,4235.1,2742.7,1239.7,1.5623121387283239,0.6436827223704032,0.2791153454454192,0.5542162858364753,0.512834102529052,0.29002310274091914,3978]
["O75828","Carbonyl reductase [NADPH] 3 [OS=Homo sapiens]",43,10,31,6,277,30.8,6.18,97.68,"other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","CBR3","ENSG00000159231","Arachidonic acid metabolism; Metabolism of xenobiotics by cytochrome P450; Metabolic pathways","Phase I - Functionalization of compounds","Nuclear receptors meta-pathway; NRF2 pathway",1084.5,1080,1116.9,986.2,1054.3,967.3,1.0909634949132256,0.12560282797794636,0.034192556932421986,1.466068421282374,0.1931324564289585,0.7141447357310827,1294]
["O75832","26S proteasome non-ATPase regulatory subunit 10 [OS=Homo sapiens]",54,9,38,9,226,24.4,6.1,130.27,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","PSMD10","ENSG00000101843","","Degradation of DVL; Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Parkin-ubiquitin proteasomal system pathway",3765.9,3557.4,3558.3,3896.7,3581.6,7583.3,0.7224730440325067,-0.4689843342167561,0.339704417180465,0.4688988059570864,0.5527381088984904,0.25748059166253356,4492]
["O75843","AP-1 complex subunit gamma-like 2 [OS=Homo sapiens]",5,4,6,4,785,87.1,6.55,14.17,"transport","other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","AP1G2","ENSG00000213983","Lysosome; Human immunodeficiency virus 1 infection","Lysosome Vesicle Biogenesis","",519.5,489.4,492.1,534.2,524.9,860.7,0.7818522762787791,-0.355032045426739,0.2763178227378376,0.5585911018114605,0.5097443125671013,0.2926476111300158,3962]
["O75844","caax prenyl protease 1 homolog [OS=Homo sapiens]",31,14,57,14,475,54.8,7.49,155.37,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZMPSTE24","ENSG00000084073","Terpenoid backbone biosynthesis","","Adipogenesis; Lamin A-processing pathway; Nephrotic syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy",7468.3,7443.5,7622.6,5900.9,6486.7,3979.5,1.3768107972701336,0.46133031648479594,0.05367751178997956,1.2702076240038775,0.24307864539836468,0.6142531925059561,1614]
["O75865-1","Trafficking protein particle complex subunit 6A [OS=Homo sapiens]",6,1,1,1,159,17.6,5.26,2.3,"cell organization and biogenesis;transport;other biological processes","cytosol;ER/Golgi;other cell component","","TRAPPC6A","ENSG00000007255","","RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport","",34.3,30.2,39,32.7,26.5,20.4,1.300251256281407,0.37879043184303873,0.14217055736047474,0.8471903339847197,0.37772613731287163,0.4228229624904303,2751]
["O75874","Isocitrate dehydrogenase [NADP] cytoplasmic [OS=Homo sapiens]",52,22,138,21,414,46.6,7.01,357.16,"other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","IDH1","ENSG00000138413","Citrate cycle (TCA cycle); Glutathione metabolism; Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids; Peroxisome; Central carbon metabolism in cancer","Peroxisomal protein import; Neutrophil degranulation; Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate; NADPH regeneration","Glutathione metabolism; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism",17227.1,17258.2,16765.4,16471.9,16563,15304.6,1.060224040381055,0.08436915893338932,0.08970650729761716,1.0471760521516391,0.3068155647348076,0.5131226124317356,2137]
["O75879","Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial [OS=Homo sapiens]",11,5,11,5,557,61.8,8.63,26.29,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","other molecular function","GATB","ENSG00000059691","Aminoacyl-tRNA biosynthesis; Metabolic pathways","","",789.1,823.6,813.9,777.3,836.9,765.8,1.0195798319327731,0.027974741146011665,0.5576230141727542,0.2536593103727892,0.6929048980939578,0.15932636865986685,5882]
["O75880","Protein SCO1 homolog, mitochondrial [OS=Homo sapiens]",5,2,5,2,301,33.8,8.88,12.22,"cell organization and biogenesis;other biological processes","other membranes;cytoskeleton;mitochondrion","other molecular function","SCO1","ENSG00000133028","","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis",948.1,888.5,870.2,968.9,1023.5,703.3,1.0041176688800684,0.005928343354977652,0.9727093696728796,0.012016900740503964,0.9811665447059174,0.008257268555049005,7246]
["O75882-1","Attractin [OS=Homo sapiens]",1,3,3,3,1429,158.4,7.31,6.16,"cell adhesion;stress response;developmental processes;other biological processes","extracellular matrix;plasma membrane;other membranes;other cell component","other molecular function","ATRN","ENSG00000088812","","","",447.2,451.4,468.5,502.7,528.6,399.5,0.9554794520547945,-0.06570324705082976,0.6233569883299717,0.20526316737099676,0.7417968459302773,0.12971501759407386,6142]
["O75884-1","Putative hydrolase RBBP9 [OS=Homo sapiens]",16,3,3,3,186,21,6.2,8.55,"other biological processes","nucleus","other molecular function","RBBP9","ENSG00000089050; ENSPPAG00000038694; ENSPTRG00000013289","","","",446.2,684.1,469.6,629.3,542.8,1616.2,0.5737904816554891,-0.8014040587820402,0.32400370645765886,0.48945002163011153,0.5441505263095194,0.2642809464362621,4352]
["O75886","Signal transducing adapter molecule 2 [OS=Homo sapiens]",17,8,15,7,525,58.1,5.07,44.99,"cell organization and biogenesis;other metabolic processes;transport;signal transduction","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","STAM2","ENSG00000115145","Endocytosis; JAK-STAT signaling pathway","Ub-specific processing proteases; Endosomal Sorting Complex Required For Transport (ESCRT); RHOU GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell","EGF/EGFR signaling pathway",1105.7,1155,1100.2,1165.2,1212,1007.9,0.9928510236034387,-0.010350835978185504,0.905986647843862,0.042878202776235816,0.9374088914341431,0.02807093146177505,7064]
["O75907","Diacylglycerol O-acyltransferase 1 [OS=Homo sapiens]",9,3,6,3,488,55.2,9.32,23.89,"cell organization and biogenesis;other metabolic processes;other biological processes","plasma membrane;other membranes;ER/Golgi","other molecular function","DGAT1","ENSG00000185000; ENSG00000285482","Glycerolipid metabolism; Retinol metabolism; Metabolic pathways; Fat digestion and absorption","Neutrophil degranulation; Acyl chain remodeling of DAG and TAG; Triglyceride biosynthesis","Triacylglyceride synthesis; Statin inhibition of cholesterol production; Glycerolipids and glycerophospholipids; Congenital generalized lipodystrophy (CGL); Vitamin A and carotenoid metabolism",438.2,496,491,416.8,415.5,494.6,1.0740824478106865,0.10310474051348972,0.36412191259733717,0.4387531847470415,0.5657668067971806,0.2473625359311506,4704]
["O75909","Cyclin-K [OS=Homo sapiens]",12,5,9,5,580,64.2,8.41,32.68,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","CCNK","ENSG00000090061","","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; RNA polymerase II transcribes snRNA genes","Male infertility",612.8,636.2,664.5,628.6,647.2,576.7,1.032928475033738,0.046740358475299205,0.47556137334079296,0.32279342744738276,0.6373080450582793,0.19565059916902094,5454]
["O75915","PRA1 family protein 3 [OS=Homo sapiens]",28,6,74,6,188,21.6,9.77,239.08,"other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi","","ARL6IP5","ENSG00000144746","","Glutamate Neurotransmitter Release Cycle","",7189.6,7113.9,6862.5,6170.4,6535.6,8579.9,0.9943671632395152,-0.008149439500285661,0.9603861012445969,0.01755413370086455,0.9730332705845243,0.011872309799235934,7214]
["O75925","E3 SUMO-protein ligase PIAS1 [OS=Homo sapiens]",4,2,4,1,651,71.8,7.3,11.56,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PIAS1","ENSG00000033800","Ubiquitin mediated proteolysis; JAK-STAT signaling pathway; Hepatitis C","SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of transcription cofactors; SUMOylation of intracellular receptors; Regulation of IFNG signaling; SUMOylation of transcription factors; Formation of Incision Complex in GG-NER","Androgen receptor signaling pathway; Interleukin-11 signaling pathway; Mesodermal commitment pathway; TGF-beta signaling pathway; Immune response to tuberculosis; Interferon type I signaling pathways",401.7,399.4,382.4,470.5,467,382.3,0.8967267767843613,-0.15725961679195724,0.198005689483661,0.7033223305674638,0.4385526013442662,0.35797830856137824,3300]
["O75928-1","E3 SUMO-protein ligase PIAS2 [OS=Homo sapiens]",4,2,4,1,621,68.2,7.52,10.58,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PIAS2","ENSG00000078043; ENSPTRG00000009998","Ubiquitin mediated proteolysis; JAK-STAT signaling pathway","Activation of anterior HOX genes in hindbrain development during early embryogenesis","Androgen receptor signaling pathway; TGF-beta signaling pathway",59.7,72.3,74.4,65.8,72.4,40.1,1.1575995513180033,0.21113626779825911,0.43742448151545094,0.35909691428069673,0.6089781972183678,0.21539825580268065,5250]
["O75934","Pre-mRNA-splicing factor spf27 [OS=Homo sapiens]",31,7,15,7,225,26.1,5.66,52.21,"RNA metabolism OR transcription;other metabolic processes","cytoskeleton;nucleus;other cell component","","BCAS2","ENSG00000116752","Spliceosome","mRNA Splicing - Major Pathway","",1217.9,1048.3,1006.8,1514.6,1671.1,2946.4,0.5337486342362322,-0.9057676217385636,0.10592760382544154,0.9749908517251559,0.331858061020211,0.4790476286349355,2333]
["O75935","Dynactin subunit 3 [OS=Homo sapiens]",45,7,19,7,186,21.1,5.47,63.76,"cell cycle OR cell proliferation;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","DCTN3","ENSG00000137100","Amyotrophic lateral sclerosis; Huntington disease; Pathways of neurodegeneration; Salmonella infection","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic","",2725,2438.8,2449.5,2600.6,2898.2,2779.9,0.919625061905855,-0.1208823115252546,0.15692184008108495,0.8043166079324071,0.3949523860718491,0.40345525807649024,2904]
["O75937","DnaJ homolog subfamily C member 8 [OS=Homo sapiens]",12,3,7,3,253,29.8,9.06,20.11,"","non-structural extracellular;cytosol;nucleus","other molecular function","DNAJC8","ENSG00000126698; ENSG00000285317","","mRNA Splicing - Major Pathway","mRNA processing",1042.3,742,1233.4,947.1,826.4,502,1.326170072511536,0.40726580338054474,0.2738374502339397,0.5625071576712513,0.5083764093878246,0.29381461057750774,3937]
["O75940","Survival of motor neuron-related-splicing factor 30 [OS=Homo sapiens]",29,4,9,4,238,26.7,7.24,25.68,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","SMNDC1","ENSG00000119953","Spliceosome","mRNA Splicing - Major Pathway","",310.5,313.4,301.5,424.6,410.3,895.7,0.534727840055472,-0.9031233037607391,0.16773269636801982,0.7753822715136467,0.4083805055808984,0.3889349975369253,3002]
["O75943-1","cell cycle checkpoint protein RAD17 [OS=Homo sapiens]",5,3,6,3,681,77,7.06,17.38,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","other molecular function","RAD17","ENSG00000152942; ENSG00000276618","","Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA)","miRNA regulation of DNA damage response; Gastric cancer network 2; DNA damage response",456.5,476.4,472.2,485,449.7,308.9,1.129864908330653,0.17615028792162324,0.37626468903089977,0.4245065366059664,0.572464323923157,0.24225157345286186,4804]
["O75947-1","ATP synthase subunit d, mitochondrial [OS=Homo sapiens]",41,6,30,6,161,18.5,5.3,46.16,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","ATP5PD","ENSG00000167863; ENSGGOG00000013716; ENSPTRG00000009628","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",1872,1854.7,1750.3,2101.4,2263.5,1748.1,0.8959594307214134,-0.15849468673630862,0.2478386322520228,0.6058309963208206,0.4846047520412078,0.3146123314796609,3738]
["O75955","Flotillin-1 [OS=Homo sapiens]",43,17,73,16,427,47.3,7.49,227.45,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","FLOT1","ENSG00000137312; ENSG00000206379; ENSG00000206480; ENSG00000230143; ENSG00000232280","Insulin signaling pathway","RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Regulation of necroptotic cell death; Synaptic adhesion-like molecules","Angiopoietin-like protein 8 regulatory pathway; Insulin signaling",5574.3,5721,6038,5138.6,4898,5841.8,1.091627619911326,0.12648080266074646,0.19790657081909754,0.7035397862731294,0.43873191571634335,0.3578007715323094,3297]
["O75962-1","Triple functional domain protein [OS=Homo sapiens]",4,7,9,6,3097,346.7,6.37,31.13,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;other cell component","enzyme regulator activity;kinase activity;other molecular function","TRIO","ENSG00000038382","","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; G alpha (q) signalling events; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; DCC mediated attractive signaling","Microtubule cytoskeleton regulation; Cell migration and invasion through p75NTR; Neural crest cell migration during development; Neural crest cell migration in cancer",333,325.3,332.7,345.4,310.9,370.8,0.9648524973225587,-0.051619688927922056,0.5303735982844249,0.27541810301348496,0.6732373445399203,0.17183180167157522,5758]
["O75962-3","Isoform 3 of Triple functional domain protein [OS=Homo sapiens]",4,2,2,1,596,66.2,7.08,5.3,"","","","TRIO","","","","",215.9,192.6,189.3,190.7,183.2,353.7,0.8216052776250687,-0.28348264597339184,0.4846990184218532,0.3145278597787971,0.6442380661293554,0.19095361757670318,5499]
["O75964","ATP synthase subunit g, mitochondrial [OS=Homo sapiens]",30,3,27,3,103,11.4,9.64,83.87,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","ATP5MG","ENSG00000167283","Oxidative phosphorylation; Metabolic pathways; Thermogenesis","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",3196.4,3114.8,3263.6,2797.8,2748.8,1744.5,1.313217484330211,0.3931058633608496,0.09258409895996715,1.0334635956823026,0.3119857903634854,0.5058651858125229,2169]
["O75976","Carboxypeptidase D [OS=Homo sapiens]",11,11,15,11,1380,152.8,6.05,44.86,"protein metabolism;other metabolic processes","non-structural extracellular;plasma membrane;other membranes","other molecular function","CPD","ENSG00000108582","","Golgi Associated Vesicle Biogenesis; RND3 GTPase cycle; RND1 GTPase cycle","",1225.6,1210.1,1268,1315.8,1350.9,1142,0.9724315383201617,-0.040331410652511425,0.6283078323341951,0.20182752643984642,0.7459879705215451,0.1272681757153146,6156]
["O75995","SAM and SH3 domain-containing protein 3 [OS=Homo sapiens]",59,12,44,12,380,41.6,5.27,179.05,"other biological processes","nucleus;other cell component","","SASH3","ENSG00000122122","","","",3432.9,3090.8,3199.8,3914.9,3524.3,4284.5,0.8293883330347928,-0.2698803418214873,0.05084386177666028,1.2937614706160718,0.23654855870503502,0.6260796937720722,1571]
["O76003","glutaredoxin-3 [OS=Homo sapiens]",36,11,63,11,335,37.4,5.39,205.95,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","GLRX3","ENSG00000108010","","Iron uptake and transport","",9243,9399,8958.3,9436.3,9781.2,9935.1,0.9467526052564781,-0.07894060879041681,0.057531985584200654,1.240090637040364,0.2507461434913074,0.6007657377624768,1677]
["O76021","Ribosomal L1 domain-containing protein 1 [OS=Homo sapiens]",44,21,75,21,490,54.9,10.13,204.17,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","RSL1D1","ENSG00000171490","","","Senescence and autophagy in cancer",8483.2,8533,8362,17856.3,17706.9,16358.4,0.4887792363871683,-1.0327450949138595,5.0572142316738631E-5,4.296088648569724,0.014216607238193948,1.8472040346565695,26]
["O76024","Wolframin [OS=Homo sapiens]",18,13,34,13,890,100.2,8.05,95.23,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","WFS1","ENSG00000109501","Protein processing in endoplasmic reticulum","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; XBP1(S) activates chaperone genes","CAMKK2 pathway",3044.2,3014.4,3094.5,2999.6,3124.4,3463.7,0.9546710889994472,-0.06692432509231674,0.3611249192360068,0.44234254227577846,0.5645908095606361,0.24826619560034208,4675]
["O76031","ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial [OS=Homo sapiens]",46,25,57,25,633,69.2,7.58,171.36,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","CLPX","ENSG00000166855","","","",6738.8,6762,6620,7453.4,7718.1,7069.6,0.9046674849715167,-0.14454047499333328,0.021659160353355005,1.6643583833973434,0.1555076650517404,0.8082481995141103,1018]
["O76039-1","Cyclin-dependent kinase-like 5 [OS=Homo sapiens]",2,2,4,1,1030,115.5,9.54,11.44,"","","","CDKL5","","","","",241.6,218.8,239,219.9,161.5,103.8,1.441467436108821,0.5275382455772061,0.10569121580807012,0.9759611062082928,0.3315438181721822,0.47945906535033883,2330]
["O76062","Delta(14)-sterol reductase [OS=Homo sapiens]",16,4,8,4,418,46.4,8.87,24.51,"other metabolic processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","other molecular function","TM7SF2","ENSG00000149809","Steroid biosynthesis; Metabolic pathways","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways",642.9,652.8,694.8,582.3,511.7,578,1.1904904306220092,0.25155602401046634,0.018890588857996906,1.7237545040266733,0.14735465737790757,0.8316361330304785,937]
["O76071","Probable cytosolic iron-sulfur protein assembly protein Ciao1 [OS=Homo sapiens]",43,10,29,10,339,37.8,4.97,123.12,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;other cell component","","CIAO1","ENSG00000144021","","Cytosolic iron-sulfur cluster assembly","",3287.3,3428.2,3306.6,3328.8,3171.5,2221.2,1.1491257237860462,0.20053664929821172,0.2817461899591132,0.5501419481866331,0.5155941167779565,0.2876920468373439,3994]
["O76074","cGMP-specific 3',5'-cyclic phosphodiesterase [OS=Homo sapiens]",18,14,21,14,875,99.9,6.09,54.97,"other metabolic processes;signal transduction","cytosol","other molecular function","PDE5A","ENSG00000138735","Purine metabolism; Metabolic pathways; cGMP-PKG signaling pathway","cGMP effects; RHOBTB1 GTPase cycle","Phosphodiesterases in neuronal function",1252.4,1238.5,1221.7,1482,1500.7,1847,0.7687019897716216,-0.3795036920279095,0.03521856589103985,1.4532283325904476,0.19383471242289932,0.7125684457384733,1328]
["O76075","DNA fragmentation factor subunit beta [OS=Homo sapiens]",12,3,6,3,338,39.1,9,17.17,"cell organization and biogenesis;DNA metabolism;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DFFB","ENSG00000169598","Apoptosis","Apoptosis induced DNA fragmentation","Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis",486.9,449.9,485.7,508.8,422.7,3393.7,0.3288865254785906,-1.6043381928965712,0.3777916961208183,0.4227475921223386,0.5734744562714561,0.24148592169891894,4815]
["O76080","AN1-type zinc finger protein 5 [OS=Homo sapiens]",8,1,1,1,213,23.1,8.51,4.43,"developmental processes;signal transduction;other biological processes","other cell component","nucleic acid binding activity;other molecular function","ZFAND5","ENSG00000107372","","","",71.5,58.7,69.4,108.3,110.2,108.1,0.6111451316595223,-0.7104130702244345,4.5962667328981543E-4,3.337594776053273,0.02871291756474582,1.5419226759154614,117]
["O76094","Signal recognition particle subunit SRP72 [OS=Homo sapiens]",38,21,73,21,671,74.6,9.26,247.63,"transport","cytosol;ER/Golgi;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","SRP72","ENSG00000174780","Protein export","SRP-dependent cotranslational protein targeting to membrane","",9456.2,9390.9,10401,10519.1,9201.6,8103.1,1.0511899884271738,0.0720234405567001,0.5712973475165437,0.24313779232594254,0.7028467114961148,0.15313938281865658,5941]
["O76095-1","Protein JTB [OS=Homo sapiens]",9,1,1,1,146,16.3,8.28,3.64,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion;other cell component","other molecular function","JTB","ENSG00000143543; ENSGGOG00000005608; ENSPPAG00000028370; ENSPTRG00000001369","","","",57.1,60.8,58.3,71.7,76.3,67.8,0.8164967562557923,-0.29248094056760343,0.00797627857371314,2.0981996865778307,0.09948569982127872,1.0022393407119488,586]
["O77932","Decapping and exoribonuclease protein [OS=Homo sapiens]",5,2,3,2,396,44.9,7.69,7.27,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus","nucleic acid binding activity;other molecular function","DXO","ENSG00000204348; ENSG00000206346; ENSG00000224313; ENSG00000225682; ENSG00000234798; ENSG00000236765","","","",371.5,372.8,371.6,384.9,367.5,363.2,1.0002689135891003,3.879081468739567E-4,0.9887171969333111,4.927912017327148E-3,0.9917022083690916,3.6187196581471655E-3,7287]
["O94760-1","N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 [OS=Homo sapiens]",33,8,25,7,285,31.1,5.81,85.27,"other metabolic processes;signal transduction;other biological processes","cytosol","other molecular function","DDAH1","ENSG00000153904; ENSMFAG00000037521; ENSMMUG00000014573; ENSMNEG00000044101; ENSRBIG00000034663; ENSRROG00000009892","","eNOS activation","Mesodermal commitment pathway; Nitric oxide metabolism in cystic fibrosis",3056.4,3221.9,3053.1,2876.7,2912.8,2412.7,1.137670381117261,0.18608262406783782,0.09172402874314711,1.0375168782498556,0.3102318029077567,0.508313683249124,2161]
["O94761","ATP-dependent DNA helicase Q4 [OS=Homo sapiens]",7,6,8,6,1208,133,8.09,22.05,"","","","","","","","",482.7,445.7,501,461.1,447.4,518,1.0020329477742727,0.002929946466323569,0.9732059220089133,0.0117952570285519,0.9815319558387122,0.008095556462857182,7247]
["O94762-1","ATP-dependent DNA helicase Q5 [OS=Homo sapiens]",6,5,7,5,991,108.8,8.56,19.38,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RECQL5","ENSG00000108469","","","",597.1,609.7,650.4,760.7,768.6,1122.2,0.7004337167640958,-0.5136795624614466,0.09253329597081462,1.0337019682935344,0.3121023812878099,0.5057029177293794,2167]
["O94763-1","Unconventional prefoldin RPB5 interactor 1 [OS=Homo sapiens]",10,5,6,5,535,59.8,5.05,19.81,"other biological processes","cytosol;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","URI1","ENSG00000105176","","","",691.8,679,698.7,787.8,830.6,502.8,0.9756270035828776,-0.03559840502309296,0.8752885729886528,0.05784874126901917,0.914710348866752,0.03871640735827217,6994]
["O94766","Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 [OS=Homo sapiens]",18,4,7,4,335,37.1,8.27,23.83,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","enzyme regulator activity;other molecular function","B3GAT3","ENSG00000149541","Glycosaminoglycan biosynthesis; Glycosaminoglycan biosynthesis; Metabolic pathways","A tetrasaccharide linker sequence is required for GAG synthesis; Defective B3GAT3 causes JDSSDHD","Proteoglycan biosynthesis",595.6,602.9,563.9,565.6,560.6,748,0.9403478817628855,-0.08873351421829911,0.5848388096001217,0.23296381553732384,0.7137396659487877,0.14646016673755965,5989]
["O94768","Serine/threonine-protein kinase 17B [OS=Homo sapiens]",16,5,12,5,372,42.3,5.25,31.11,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus","kinase activity;other molecular function","STK17B","ENSG00000081320","","","",865.2,828.3,812.4,922.7,877.1,2321,0.6081100757134537,-0.7175956012972469,0.3196565986258825,0.49531632605811576,0.5408264072584665,0.2669421109890549,4320]
["O94776","Metastasis-associated protein MTA2 [OS=Homo sapiens]",41,28,99,27,668,75,9.66,247.68,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MTA2","ENSG00000149480","","Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation","Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome",10516.2,10554.1,10606.4,11132,10996.7,10456,0.9721341611246996,-0.04077266559044804,0.2196182889347872,0.6583314964044269,0.46099657490647894,0.3363023013017663,3482]
["O94788-1","retinal dehydrogenase 2 [OS=Homo sapiens]",3,2,5,1,518,56.7,6.05,11.85,"cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;other cell component","other molecular function","ALDH1A2","ENSG00000128918","Retinol metabolism; Metabolic pathways","RA biosynthesis pathway","Ethanol effects on histone modifications; Tryptophan metabolism; 22q11.2 copy number variation syndrome; Vitamin A and carotenoid metabolism",794,801.6,784.5,778.3,781,1723.3,0.7250654968622433,-0.46381677185581494,0.39308743317823275,0.4055108401498618,0.5825377228507103,0.2346759461895829,4932]
["O94804","Serine/threonine-protein kinase 10 [OS=Homo sapiens]",35,32,105,30,968,112.1,6.95,298.67,"cell adhesion;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol","kinase activity;other molecular function","STK10","ENSG00000072786","Progesterone-mediated oocyte maturation","RHOA GTPase cycle; RHOB GTPase cycle; Neutrophil degranulation; RHOC GTPase cycle","",10425.3,9578,10504.3,11283,10993.2,8945.6,0.9771249575617035,-0.03338502488713672,0.7790005164480023,0.10846225440645578,0.8495545769499327,0.07080871602173547,6702]
["O94806","Serine/threonine-protein kinase D3 [OS=Homo sapiens]",18,12,29,9,890,100.4,6.87,95.06,"protein metabolism;other metabolic processes;signal transduction","other membranes;cytosol;nucleus","kinase activity;other molecular function","PRKD3","ENSG00000115825","Rap1 signaling pathway; Aldosterone synthesis and secretion; Chemical carcinogenesis","Sphingolipid de novo biosynthesis","G protein signaling pathways; Hippo signaling regulation pathways",2324,2397.4,2301.4,2691.5,2633.2,3264.2,{"$f":"AVERAGE(S706:U706)/AVERAGE(V706:X706)","v":0.8176600030271628},{"$f":"LOG(Y706,2)","v":-0.29042702423147915},{"$f":"TTEST(V706:X706,S706:U706,2,2)","v":0.06220304697528594},1.2061883411589798,{"$f":"AA706*7309/AE706","v":0.257587575264796},0.5890750889988482,1765]
["O94811","Tubulin polymerization-promoting protein [OS=Homo sapiens]",24,4,5,4,219,23.7,9.44,10.69,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","TPPP","ENSG00000171368","","","Microtubule cytoskeleton regulation; Glial cell differentiation; Sudden infant death syndrome (SIDS) susceptibility pathways",483.4,415,495.2,435.5,410.6,309.8,1.2056406263517605,0.26979993721815837,0.15899747878750795,{"$f":"-LOG10(AA707)","v":0.7986097622037889},0.3970319687249387,{"$f":"-LOG10(AC707)","v":0.40117452275360793},2927]
["O94813","Slit homolog 2 protein [OS=Homo sapiens]",0,1,1,1,1529,169.8,7.06,1.9,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;other membranes;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","SLIT2","ENSG00000145147","Axon guidance","Regulation of expression of SLITs and ROBOs; Netrin-1 signaling; Inactivation of CDC42 and RAC1; Activation of RAC1; Regulation of commissural axon pathfinding by SLIT and ROBO; Role of ABL in ROBO-SLIT signaling; SLIT2:ROBO1 increases RHOA activity","Spinal cord injury; Robo4 and VEGF signaling pathways crosstalk; Genes controlling nephrogenesis; GDNF/RET signaling axis; Development of ureteric collection system",154.2,154.7,158.8,172.1,165.3,13.5,1.3328583642063268,0.4145234810167745,0.49402176967592665,0.30625391293502974,0.6509473795856044,0.18645411692989228,5547]
["O94822","E3 ubiquitin-protein ligase listerin [OS=Homo sapiens]",20,28,49,28,1766,200.4,6.25,119.14,"protein metabolism;other metabolic processes","cytosol;other cell component","translation activity;other molecular function","LTN1","ENSG00000198862","","Antigen processing: Ubiquitination & Proteasome degradation","",4153.1,4473.1,4341.2,4862.3,4536.2,4651.4,0.9229531882789203,-0.11567061792693019,0.053573794925647324,1.2710475890780653,0.24290996719079175,0.6145546646631641,1612]
["O94826","Mitochondrial import receptor subunit TOM70 [OS=Homo sapiens]",57,28,155,28,608,67.4,7.12,436.56,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","TOMM70","ENSG00000154174","","Mitochondrial protein import; Ub-specific processing proteases; DDX58/IFIH1-mediated induction of interferon-alpha/beta; PINK1-PRKN Mediated Mitophagy","Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation",20795.5,20629.6,20883.3,18930.9,19424.1,14765.8,1.1729567325793284,0.23014979696018928,0.10720114339004772,0.969800582503881,0.3335603052523877,0.47682563739751394,2349]
["O94829","Importin-13 [OS=Homo sapiens]",13,11,22,11,963,108.1,5.3,61.34,"transport","nucleus;other cell component","other molecular function","IPO13","ENSG00000117408","Nucleocytoplasmic transport","","",1583.3,1623.3,1648.2,1528.8,1463.9,2174.7,0.9395053605294733,-0.09002670164306949,0.6709499568318811,0.17330987071364917,0.774474610626061,0.11099281501999453,6332]
["O94830","Phospholipase DDHD2 [OS=Homo sapiens]",5,3,3,3,711,81,5.39,2.46,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","DDHD2","ENSG00000085788","","Synthesis of PA","",82.5,72.6,78.2,85.4,77.2,94.5,0.9074290159471022,-0.14014330284945686,0.2404641418263896,0.6189496767454551,0.4777255810299216,0.3208215026926092,3679]
["O94832","Unconventional myosin-Id [OS=Homo sapiens]",39,37,92,37,1006,116.1,9.39,237.91,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","MYO1D","ENSG00000176658","Pathogenic Escherichia coli infection","","",10935.2,11112.8,11275.5,9151.4,8683.2,9277.3,1.2291097267251652,0.2976137156584637,5.4820343900620209E-4,3.2610582443588476,0.03058640408928497,1.514471578130639,131]
["O94842","TOX high mobility group box family member 4 [OS=Homo sapiens]",11,5,6,4,621,66.2,5.06,17.83,"other biological processes","nucleus;other cell component","nucleic acid binding activity","TOX4","ENSG00000092203","","","",568.7,522.2,519.5,648.7,697,598.9,0.8281394631286642,-0.2720543491176567,0.026623092579974122,1.5747414976063907,0.17250725502396352,0.7631926353697414,1128]
["O94854","Uncharacterized protein KIAA0754 [OS=Homo sapiens]",2,1,1,1,1291,135.1,4.21,2.88,"","","","KIAA0754","","","","",15.4,8.5,13.9,17.9,16.3,5.2,0.9593908629441623,-0.0598093952353038,0.9115606360545596,0.04021443723607191,0.9410447300738385,0.026389733041867952,7080]
["O94855","Protein transport protein Sec24D [OS=Homo sapiens]",22,19,48,18,1032,112.9,7.25,143.74,"cell organization and biogenesis;transport;developmental processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","SEC24D","ENSG00000150961","Protein processing in endoplasmic reticulum; Pathogenic Escherichia coli infection","MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Sterol regulatory element-binding proteins (SREBP) signaling",3453.5,3645.7,3767.6,4096.1,3868.7,3572,0.9419249705290895,-0.08631594901599957,0.2759424051813136,0.5591815546091806,0.5098238219085492,0.2925798756503495,3956]
["O94864-1","STAGA complex 65 subunit gamma [OS=Homo sapiens]",17,3,4,3,414,46.2,5.12,5.49,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","SUPT7L","ENSG00000119760; ENSPTRG00000011777","","HATs acetylate histones","",379.9,358.5,337.1,410.9,490.8,375.1,0.8423402255639096,-0.24752503191192274,0.13874030757015435,0.8577973470581043,0.3751583085572542,0.42578543087285675,2703]
["O94868","F-BAR and double SH3 domains protein 2 [OS=Homo sapiens]",13,8,12,8,740,84.2,5.77,33.34,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","FCHSD2","ENSG00000137478","","","",773.1,858.7,845.4,1063.9,1058.2,1040.8,0.7832052862879003,-0.35253759236199456,1.1426217356259672E-3,2.9420975187905807,0.04217890033176866,1.3749047471681388,198]
["O94874-1","E3 UFM1-protein ligase 1 [OS=Homo sapiens]",51,38,145,15,794,89.5,6.79,367.15,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","UFL1","ENSG00000014123","","Antigen processing: Ubiquitination & Proteasome degradation","",14498.6,14620.9,15467.4,13778.2,13336.4,12167.2,1.1350523652174798,0.18275885724912339,0.03594600662811897,1.4443493499460038,0.195920479078987,0.7079201659136298,1341]
["O94874-3","Isoform 3 of E3 UFM1-protein ligase 1 [OS=Homo sapiens]",52,23,71,1,509,57.5,6.3,196.23,"","","","UFL1","","","","",35.8,49.5,56.5,51.3,34.9,11.4,1.4528688524590168,0.5389044796766302,0.32291887183215584,0.4909065734620173,0.543202309371974,0.26503839236272964,4345]
["O94876","Transmembrane and coiled-coil domains protein 1 [OS=Homo sapiens]",11,5,7,5,653,72,6.55,21.85,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","TMCC1","ENSG00000172765","","","",189.4,167.9,197.6,177.2,164.3,316,0.8439543726235742,-0.2447630914158953,0.526521998637746,0.2785834788234253,0.67149699669225,0.17295592539720192,5731]
["O94880","PHD finger protein 14 [OS=Homo sapiens]",9,7,14,7,888,100,5.33,29.98,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","PHF14","ENSG00000106443","","","",1562.2,1514.7,1563.6,1787.5,1894.9,2230.1,0.784862579281184,-0.34948801864713164,0.03424398031573845,1.4654157612643124,0.19297552207226856,0.7144977754644195,1297]
["O94886","CSC1-like protein 1 [OS=Homo sapiens]",18,10,23,10,807,92.1,7.27,71.54,"transport","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","transporter activity;nucleic acid binding activity","TMEM63A","ENSG00000196187","","Neutrophil degranulation","",1995.3,2064.3,2100.5,1983.4,1961.1,2328.4,0.982017886463996,-0.026178792874989427,0.7747889491327564,0.11081658228035396,0.8466037418465118,0.07231981634901428,6689]
["O94887-1","FERM, RhoGEF and pleckstrin domain-containing protein 2 [OS=Homo sapiens]",11,7,7,7,1054,119.8,8.79,30.06,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity","FARP2","ENSG00000006607","Rap1 signaling pathway; Adherens junction","RAC1 GTPase cycle; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion","",564.3,526.2,576.8,500.7,469,1188.4,0.7725777304110095,-0.37224800246978784,0.5249685948092374,0.2798666766112033,0.6713902816204228,0.17302494945853084,5715]
["O94888","UBX domain-containing protein 7 [OS=Homo sapiens]",42,16,38,15,489,54.8,5.16,97.06,"","other membranes;cytosol;ER/Golgi;nucleus","other molecular function","UBXN7","ENSG00000163960","","Neddylation","3q29 copy number variation syndrome",3721.9,3627.7,3570.2,4127.1,4283.4,6674,0.7239086479498822,-0.46612044380126116,0.16785701462160416,0.7750605051886778,0.4085470928635714,0.38875787550368585,3003]
["O94901-9","Isoform 9 of SUN domain-containing protein 1 [OS=Homo sapiens]",21,14,35,13,916,101.9,7.31,101.23,"","","","SUN1","","","","",1995.6,1959.9,2067.4,1782,1924.9,2456.9,0.9771407248775106,-0.033361745116604044,0.8322308742776475,0.07975617669532363,0.8864435237678994,0.05234892853150526,6862]
["O94903","Pyridoxal phosphate homeostasis protein [OS=Homo sapiens]",43,11,42,11,275,30.3,7.5,111.97,"","cytosol;other cell component","other molecular function","PLPBP","ENSG00000147471","","","",4493.3,4638.3,4429.5,4418.8,4563.5,4315.3,1.0198156058236074,0.028308320223708706,0.4068582475165058,0.39055687589645316,0.5910806859666351,0.22835323133822832,5031]
["O94905-1","Erlin-2 [OS=Homo sapiens]",32,10,32,7,339,37.8,5.62,86.04,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","ERLIN2","ENSG00000147475; ENSGGOG00000012855; ENSPPAG00000034728; ENSPTRG00000020158","","ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Signaling by FGFR1 in disease; Signaling by plasma membrane FGFR1 fusions","",2910.5,2989.6,3200.5,2778.5,2740.5,2371.1,1.153420108743869,0.2059180796943965,0.061031472209309115,1.214446153807661,0.25740278729246413,0.5893867546376049,1733]
["O94906-1","Pre-mRNA-processing factor 6 [OS=Homo sapiens]",54,49,151,49,941,106.9,8.25,459.51,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PRPF6","ENSG00000101161; ENSGGOG00000016876; ENSPPAG00000008686; ENSPTRG00000013765","Spliceosome","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","mRNA processing; mRNA Processing",18896.3,18915.1,19304.4,18138.1,17969.8,17196.7,1.0714985198275573,0.09962985707100022,0.01635282316209536,1.7864072596472735,0.13785788292013262,0.8605683952395108,867]
["O94913","Pre-mRNA cleavage complex 2 protein Pcf11 [OS=Homo sapiens]",9,13,22,13,1555,172.9,8.48,58.17,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","PCF11","ENSG00000165494","mRNA surveillance pathway","RNA polymerase II transcribes snRNA genes; mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs","",2668.5,2604.1,2754.9,2663.5,2816.9,2522.7,1.0030488185827993,4.391823909566198E-3,0.9362410193716562,0.02861233512002281,0.9579988255057308,0.01863502336059214,7143]
["O94915-1","protein furry homolog-like [OS=Homo sapiens]",9,26,41,20,3013,339.4,5.58,118.14,"cell organization and biogenesis;developmental processes;other biological processes","other cell component","","FRYL","ENSG00000075539","","","",3861,3995,4005.2,3780.5,3708.1,3843.5,1.0466903751290582,0.0658347370840328,0.04394731749933345,1.3570676286855798,0.21925661679360284,0.6590472914917352,1465]
["O94915-2","Isoform 2 of Protein furry homolog-like [OS=Homo sapiens]",19,7,12,1,403,45.6,4.5,39.26,"","","","FRYL","","","","",269.8,264.1,316.8,300.7,286.7,341.2,0.9161102735300453,-0.12640682680581886,0.3286848400616505,0.48322032643070606,0.5458662794843453,0.2629137331096782,4401]
["O94916","nuclear factor of activated T-cells 5 [OS=Homo sapiens]",2,2,2,2,1531,165.7,5.24,2.25,"RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NFAT5","ENSG00000102908","","","Cancer immunotherapy by PD-1 blockade",82.6,87.5,91.6,100.1,112.7,130.2,0.7629737609329447,-0.3902946520121398,0.04090991965871239,1.3881713733936365,0.20953791365489058,0.6787373846243104,1427]
["O94919","endonuclease domain-containing 1 protein [OS=Homo sapiens]",25,8,25,8,500,55,5.71,78.53,"other metabolic processes","non-structural extracellular;cytosol","nucleic acid binding activity;other molecular function","ENDOD1","ENSG00000149218","","Platelet degranulation","",1508.3,1491.6,1526.1,1378.2,1398.8,1541.6,1.04802482285926,0.06767288805078642,0.2570127808529376,0.590045279330613,0.49369419586179264,0.3065419785532317,3805]
["O94921-1","Cyclin-dependent kinase 14 [OS=Homo sapiens]",14,6,12,4,469,53,8.92,26.99,"cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","CDK14","ENSCATG00000032271; ENSCSAG00000012501; ENSG00000058091; ENSGGOG00000003585; ENSMLEG00000038830; ENSMNEG00000032203; ENSPANG00000022338","Transcriptional misregulation in cancer","","",561.9,669.1,620.9,673,615.8,607.9,0.9763800284705016,-0.03448530931483651,0.7083992196196881,0.14972192590524055,0.8027426195659381,0.09542367865653535,6450]
["O94923","D-glucuronyl C5-epimerase [OS=Homo sapiens]",5,2,2,2,617,70.1,8.97,5.72,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","GLCE","ENSG00000138604","Glycosaminoglycan biosynthesis; Metabolic pathways","HS-GAG biosynthesis","",150.7,154.7,168.6,154.5,191.8,246.1,0.800135043889264,-0.3216845815032262,0.21959472921890366,0.6583780881682879,0.46107953917292926,0.3362241495686033,3481]
["O94925-1","Glutaminase kidney isoform, mitochondrial [OS=Homo sapiens]",49,24,114,5,669,73.4,7.77,364.69,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;mitochondrion;other cell component","other molecular function","GLS","ENSG00000115419; ENSGGOG00000007590; ENSPTRG00000012747","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; D-Amino acid metabolism; Metabolic pathways; Glutamatergic synapse; GABAergic synapse; Proximal tubule bicarbonate reclamation; MicroRNAs in cancer; Central carbon metabolism in cancer","Glutamate Neurotransmitter Release Cycle; TP53 Regulates Metabolic Genes; Glutamate and glutamine metabolism","Amino acid metabolism; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling",12864.6,13664.6,13325.9,12737.1,12722.9,9590.2,1.137086236312489,0.18534167198085597,0.20945758815001173,0.6789039015620918,0.45013981528622043,0.34665257161084095,3401]
["O94925-3","Isoform 3 of Glutaminase kidney isoform, mitochondrial [OS=Homo sapiens]",50,22,119,3,598,65.4,7.88,372.88,"","","","GLS","","","","",2469.8,2521.7,2489.9,2522.8,2554.2,1950,1.0646648640956309,0.09039936942076117,0.48476451464207115,0.31446917856779877,0.6442079704579815,0.1909739061780696,5500]
["O94927","HAUS augmin-like complex subunit 5 [OS=Homo sapiens]",6,3,5,3,633,71.6,8.51,15.7,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","","HAUS5","ENSG00000249115","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",213.5,219.6,234.2,232.9,213,223.9,0.9962675425500149,-0.00539487219369848,0.9258809580526879,0.03344484764227433,0.9504584160684123,0.022066879395157744,7120]
["O94941-1","RING finger protein 37 [OS=Homo sapiens]",3,1,4,1,541,58.9,7.56,12.59,"protein metabolism;other metabolic processes","nucleus;other cell component","other molecular function","UBOX5","ENSG00000185019","Ubiquitin mediated proteolysis","Antigen processing: Ubiquitination & Proteasome degradation","",37.6,42.3,28.4,40.5,35.9,63.2,0.7757879656160458,-0.36626569860132513,0.32807765457971727,0.4840233484716309,0.5459744028513556,0.26282771802969346,4392]
["O94953","lysine-specific demethylase 4B [OS=Homo sapiens]",8,6,13,6,1096,121.8,7.09,46.78,"cell organization and biogenesis;protein metabolism;other metabolic processes","nucleus","other molecular function","KDM4B","ENSG00000127663","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Estrogen-dependent gene expression; HDMs demethylate histones","",407.4,412,426.8,454.6,461.1,446.6,0.9147764809513322,-0.12850882057968652,0.005787268149270556,2.2375263944205317,0.08476782144893485,1.0717689781599486,499]
["O94964-2","Isoform 2 of Protein SOGA1 [OS=Homo sapiens]",3,5,5,3,1661,183.7,6.52,15.95,"","","","SOGA1","","","","",234.4,204,198.4,290.8,299.1,1118.2,0.3728118962590012,-1.4234801984143841,0.2633966271660895,0.5793897905455871,0.49900620735016804,0.30189405196947994,3858]
["O94966-5","Isoform 5 of Ubiquitin carboxyl-terminal hydrolase 19 [OS=Homo sapiens]",14,12,20,12,1419,155.9,6.38,58.78,"","","","USP19","","","","",789,817.9,864.6,926.5,885.7,838.2,0.9325007546030788,-0.10082320205387926,0.15157388454264623,0.8193756191263528,0.3892668735496139,0.4097525529906454,2846]
["O94973","AP-2 complex subunit alpha-2 [OS=Homo sapiens]",37,28,67,18,939,103.9,6.96,194.09,"transport","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","AP2A2","ENSG00000183020","Endocytosis; Synaptic vesicle cycle; Endocrine and other factor-regulated calcium reabsorption; Huntington disease","Neutrophil degranulation; MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; Recycling pathway of L1; Potential therapeutics for SARS; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation","Synaptic vesicle pathway; GABA receptor signaling; mBDNF and proBDNF regulation of GABA neurotransmission",3464.1,3395,3540.8,3156.2,3140.9,3008.8,1.1175598276362306,0.16035206695553583,4.413928112619878E-3,2.355174744247934,0.07520139994204822,1.1237740745486853,429]
["O94979","Protein transport protein Sec31A [OS=Homo sapiens]",41,39,144,39,1220,132.9,6.89,421.07,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","SEC31A","ENSG00000138674","Protein processing in endoplasmic reticulum","Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Signaling by ALK fusions and activated point mutants; MHC class II antigen presentation; COPII-mediated vesicle transport; XBP1(S) activates chaperone genes","Sterol regulatory element-binding proteins (SREBP) signaling",17620.1,17771.6,18310.9,17881,16696.8,16012.8,1.0615134036757814,0.08612258819523853,0.15065197617517043,0.822025167101525,0.3884004563895311,0.4107202684464774,2835]
["O94986-1","Isoform 1 of Centrosomal protein of 152 kDa [OS=Homo sapiens]",6,6,6,6,1275,147.3,5.43,14.01,"","","","CEP152","","","","",370.1,350,374.5,434.1,455.4,1351.4,0.4884644562452585,-1.033674508465123,0.2749782915404966,0.5607015906654088,0.5092009964199365,0.2931107551769511,3947]
["O94992","Protein HEXIM1 [OS=Homo sapiens]",4,2,2,2,359,40.6,4.89,2.06,"stress response;developmental processes;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","HEXIM1","ENSG00000186834","","","Initiation of transcription and translation elongation at the HIV-1 LTR",225.8,195.1,217.7,271.4,191,152,1.0393880208333333,0.05573433684893731,0.8351688587658771,0.07822570773056049,0.8877616621174804,0.05170361386160236,6876]
["O95067","G2/mitotic-specific cyclin-B2 [OS=Homo sapiens]",12,3,3,3,398,45.3,8.9,12.41,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity","CCNB2","ENSG00000157456","FoxO signaling pathway; Cell cycle; Oocyte meiosis; p53 signaling pathway; Cellular senescence; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection; Human immunodeficiency virus 1 infection","Resolution of Sister Chromatid Cohesion; Initiation of Nuclear Envelope (NE) Reformation; The role of GTSE1 in G2/M progression after G2 checkpoint; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; Cyclin A/B1/B2 associated events during G2/M transition; Golgi Cisternae Pericentriolar Stack Reorganization; Polo-like kinase mediated events; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint","miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; TGF-beta signaling pathway; IL-18 signaling pathway; DNA damage response",402.9,392.6,417,364.3,327.7,299.4,1.223017954407908,0.2904455833788881,0.021361394448286934,1.6703704004529665,0.15397478503208006,0.8125503935663106,1014]
["O95070","protein YIF1A [OS=Homo sapiens]",2,1,3,1,293,32,8.95,3.54,"transport","other membranes;ER/Golgi;other cell component","","YIF1A","ENSG00000174851","","XBP1(S) activates chaperone genes","",220.9,238.6,264.9,215.1,237.3,832.4,0.5638231631382317,-0.8266853465671465,0.40864119987246106,0.38865784921791263,0.5916716580562238,0.2279192335700176,5048]
["O95071","E3 ubiquitin-protein ligase UBR5 [OS=Homo sapiens]",17,37,75,37,2799,309.2,5.85,229.82,"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","UBR5","ENSG00000104517","Ubiquitin mediated proteolysis","","Mesodermal commitment pathway",7327.5,7346.6,7332.2,7174.1,7110.2,7044.9,1.031745213135045,0.04508674486071954,3.9284483814768754E-3,2.4057789489686314,0.07124821146455207,1.1472260332257678,403]
["O95081","Arf-GAP domain and FG repeat-containing protein 2 [OS=Homo sapiens]",2,1,1,1,481,48.9,9.11,3.14,"","","enzyme regulator activity;other molecular function","AGFG2","ENSG00000106351","","","",74.5,88,72,55.8,67.2,77.5,1.1695760598503742,0.22598568606045638,0.22943949611945527,0.6393318197813856,0.4700037211707115,0.32789870360149814,3568]
["O95104","Splicing factor, arginine/serine-rich 15 [OS=Homo sapiens]",16,15,30,14,1147,125.8,9.55,88.37,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","SCAF4","ENSG00000156304","","","",2215.6,2261.1,2313.2,2597.2,2561.5,2973,0.8349914532016675,-0.26016666435058317,0.029302934741461787,1.5330888820965152,0.1813506774135006,0.7414808178260569,1181]
["O95136","Sphingosine 1-phosphate receptor 2 [OS=Homo sapiens]",3,1,1,1,353,38.8,8.97,2.94,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","S1PR2","ENSG00000267534","Sphingolipid signaling pathway; Neuroactive ligand-receptor interaction","G alpha (i) signalling events; Lysosphingolipid and LPA receptors","Small ligand GPCRs; S1P receptor signal transduction; Sphingolipid metabolism in senescence",30.4,40.5,35.2,42.9,34.1,57.1,0.7912005965697242,-0.33788458098970897,0.2706273150888993,0.5676283711024352,0.5058862010191215,0.29594716661432907,3910]
["O95139","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [OS=Homo sapiens]",31,4,13,4,128,15.5,9.63,34.02,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB6","ENSG00000165264","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",1003.7,883.9,844.4,1164.8,1474.7,1949.2,0.5953755965741931,-0.7481280056978991,0.05665771810284977,1.2467409207315185,0.2490145890641786,0.6037752080670648,1663]
["O95140","Mitofusin-2 [OS=Homo sapiens]",18,12,18,12,757,86.3,6.98,52.88,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion","other molecular function","MFN2","ENSG00000116688","Mitophagy; NOD-like receptor signaling pathway; Parkinson disease; Pathways of neurodegeneration","Factors involved in megakaryocyte development and platelet production; PINK1-PRKN Mediated Mitophagy; RHOT2 GTPase cycle","Intracellular trafficking proteins involved in CMT neuropathy",1157.4,1183.7,1284.4,1250.4,1203.6,3013.7,0.6630758819979152,-0.5927541139646667,0.3617849841354602,0.4415494624691349,0.5646565127153701,0.2482156583672419,4683]
["O95149","Snurportin-1 [OS=Homo sapiens]",5,2,5,2,360,41.1,6.64,11.37,"transport","cytosol;nucleus","nucleic acid binding activity;other molecular function","SNUPN","ENSG00000169371","Nucleocytoplasmic transport","snRNP Assembly","",585.6,578.2,543.3,648.7,679.4,706.4,0.8390759400344067,-0.2531267081160168,0.006714525469374613,2.1729846744791392,0.09277214868744621,1.0325823846303521,529]
["O95155","Ubiquitin conjugation factor E4 B [OS=Homo sapiens]",21,21,35,20,1302,146.1,6.55,90.04,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","other molecular function","UBE4B","ENSG00000130939","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum","","",2591.1,2676.3,2606.1,2872.2,2844,2285.2,0.9840152973229686,-0.02324735127361801,0.8359355871104479,0.0778271857670131,0.8884474634564873,0.05136824822506271,6877]
["O95159","Zinc finger protein-like 1 [OS=Homo sapiens]",12,3,9,3,310,34.1,8.07,41.08,"transport;other biological processes","other membranes;ER/Golgi;nucleus","nucleic acid binding activity;other molecular function","ZFPL1","ENSG00000162300","","","",917.9,1006.3,860.5,1088.1,1111.3,1463.7,0.7602031066582949,-0.3955431739345795,0.08525730688095152,1.069268390023563,0.29958925768888206,0.5234737631023516,2080]
["O95163","Elongator complex protein 1 [OS=Homo sapiens]",21,22,60,22,1332,150.2,5.94,211.47,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","ELP1","ENSG00000070061","","HATs acetylate histones","",5595.2,5827.9,5793.5,5656.9,5616.5,4565.4,1.0869889133015127,0.12033722573183118,0.276256767791494,0.5586870737466609,0.5097603422842791,0.29263395426698086,3961]
["O95166","Gamma-aminobutyric acid receptor-associated protein [OS=Homo sapiens]",6,1,1,1,117,13.9,8.79,2.91,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","GABARAP","ENSG00000170296","FoxO signaling pathway; Autophagy; Mitophagy; Autophagy; NOD-like receptor signaling pathway; GABAergic synapse","Macroautophagy; TBC/RABGAPs","Senescence and autophagy in cancer",127.9,113.9,98.8,233.3,245.6,81.6,0.6076717216770741,-0.7186359380142466,0.24180101528389847,0.6165418799381545,0.4793391973718508,0.319357055660298,3687]
["O95167","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [OS=Homo sapiens]",49,3,11,3,84,9.3,8.46,20.56,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity","NDUFA3","ENSG00000170906; ENSG00000273642; ENSG00000274359; ENSG00000275605; ENSG00000275724; ENSG00000276061; ENSG00000276220; ENSG00000276766; ENSG00000277722; ENSG00000278365","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",1133.8,955.2,1027.3,1248.2,1493.8,758,0.8903714285714285,-0.16752079659165786,0.5960596094098356,0.2247103061268086,0.721052579473103,0.14203306518009728,6042]
["O95168-1","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [OS=Homo sapiens]",14,1,1,1,129,15.2,9.85,5.37,"cell organization and biogenesis;other metabolic processes;stress response;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB4","ENSG00000065518; ENSGGOG00000013923; ENSPPAG00000027750; ENSPTRG00000015270","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",53.5,57.8,54.6,54.2,68,286,0.40641842234198927,-1.2989622960768556,0.342621382255788,0.4651855371500539,0.5541535036307932,0.25636991659728264,4519]
["O95169","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [OS=Homo sapiens]",28,4,7,4,186,21.8,6.8,13.42,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;ER/Golgi","transporter activity","NDUFB8","ENSG00000166136","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Mitochondrial protein import; Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",742.7,782.5,731.8,726.9,834.8,1961.3,0.6406471757025264,-0.6423980563031274,0.34556399882578304,0.4614715090337586,0.5557155703889215,0.2551474347077719,4545]
["O95182","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [OS=Homo sapiens]",5,1,1,1,113,12.5,10.18,0,"protein metabolism;other metabolic processes;transport","other membranes;mitochondrion;translational apparatus","transporter activity;other molecular function","NDUFA7","ENSG00000267855","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",103.7,114,103,103.3,107.3,181.8,0.8172782874617738,-0.29110068777759185,0.40623839040112175,0.3912190372297459,0.5911201265064302,0.22832425350532223,5023]
["O95183","vesicle-associated membrane protein 5 [OS=Homo sapiens]",16,2,2,1,116,12.8,7.85,5.66,"transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","VAMP5","ENSG00000168899","SNARE interactions in vesicular transport","","",55.7,45.7,63.7,38.7,38,81.8,1.041640378548896,0.05885727988648842,0.893256439006715,0.04902384451818264,0.9267297817885138,0.033046880079584916,7045]
["O95197","Reticulon-3 [OS=Homo sapiens]",3,4,20,4,1032,112.5,4.96,41.5,"cell organization and biogenesis;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","","RTN3","ENSG00000133318","Alzheimer disease","Synaptic adhesion-like molecules","Alzheimer's disease and miRNA effects; Alzheimer's disease",3827.5,3968,3783.4,3711.6,3401.7,5506,0.9175548564500408,-0.1241336821493402,0.6261717904137853,0.203306501624231,0.7440561886090648,0.12839426676400578,6151]
["O95202-1","mitochondrial proton/calcium exchanger protein [OS=Homo sapiens]",48,34,143,34,739,83.3,6.7,456.4,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity;translation activity;other molecular function","LETM1","ENSG00000168924","","RHOG GTPase cycle; Mitochondrial calcium ion transport","",14998.4,13946.2,14735.1,12055.3,13086.7,8128.8,1.312853913942556,0.3927063912071373,0.08779246525742294,1.0565427555920905,0.30310587083916124,0.5184056517275296,2117]
["O95208-1","epsin-2 [OS=Homo sapiens]",7,5,7,4,641,68.4,7.52,20.07,"transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","EPN2","ENSG00000072134","Endocytosis","Cargo recognition for clathrin-mediated endocytosis","",486.6,548.4,455.4,578.9,661.9,950,0.6802994339967134,-0.5557582060868999,0.11382376631882758,0.9437670481037096,0.34236127902235014,0.4655153598180488,2430]
["O95210","Starch-binding domain-containing protein 1 [OS=Homo sapiens]",39,15,34,15,358,39,5.73,84.87,"other metabolic processes;transport","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","STBD1","ENSG00000118804","","Neutrophil degranulation; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle","Exercise-induced circadian regulation",4615.6,4747.6,4753.9,4578.3,4673.6,5107.1,0.983153422940316,-0.024511525479394232,0.6579097228431738,0.18183369538433583,0.765954470254979,0.11579704486438647,6278]
["O95218-1","Zinc finger Ran-binding domain-containing protein 2 [OS=Homo sapiens]",35,13,50,13,330,37.4,10.01,133.31,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","ZRANB2","ENSANAG00000018241; ENSCANG00000036472; ENSCATG00000025001; ENSG00000132485; ENSGGOG00000023501; ENSMFAG00000003326; ENSMLEG00000036639; ENSMNEG00000042080; ENSNLEG00000009455; ENSPANG00000013398; ENSPPAG00000037049; ENSPTRG00000000856; ENSSBOG00000013268","","","",8452.2,8126.9,8106.7,7434.9,8154.6,6001,{"$f":"AVERAGE(S770:U770)/AVERAGE(V770:X770)","v":1.1433639795280333},{"$f":"LOG(Y770,2)","v":0.19328474552000133},{"$f":"TTEST(V770:X770,S770:U770,2,2)","v":0.18374335911508083},0.73578834830795,{"$f":"AA770*7309/AE770","v":0.4279732988438897},0.36858332567489493,3138]
["O95219","sorting nexin-4 [OS=Homo sapiens]",11,5,6,5,450,51.9,5.99,13.91,"transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","SNX4","ENSG00000114520","Endocytosis","","",360.7,359.3,390.8,334.1,334.5,251.1,1.2077851473306513,0.27236383674169135,0.09756495021634433,{"$f":"-LOG10(AA771)","v":1.0107061727176507},0.3197767807763501,{"$f":"-LOG10(AC771)","v":0.4951530738818384},2230]
["O95229","ZW10 interactor [OS=Homo sapiens]",8,2,2,2,277,31.3,5.15,5.15,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","ZWINT","ENSG00000122952","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",178.3,167.8,161.2,325.7,411.9,405.6,0.44375437368789367,-1.172166755964677,0.001673759762087741,2.7763068769800996,0.048739084068124695,1.3121226365771645,251]
["O95232-1","Luc7-like protein 3 [OS=Homo sapiens]",49,22,71,22,432,51.4,9.79,189.39,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity","LUC7L3","ENSCANG00000028098; ENSCATG00000034891; ENSG00000108848; ENSGGOG00000024399; ENSMLEG00000034172; ENSMMUG00000010117; ENSPPAG00000025115; ENSPTRG00000009409; ENSRROG00000039925","","","",7411.9,7597.1,7576.8,7671.2,8059.8,11482.6,0.8299453214569187,-0.2689118030801211,0.2721554877535617,0.5651829041282367,0.5075744985942288,0.2945002057223663,3919]
["O95235","kinesin-like protein KIF20A [OS=Homo sapiens]",19,14,24,14,890,100.2,6.92,75.44,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","KIF20A","ENSG00000112984","","COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Mitotic Telophase/Cytokinesis","",1517,1511.9,1546.2,1083.2,1061.5,1186.7,1.373326529387045,0.4576746890825671,4.9298957498667036E-4,3.3071622644421073,0.029294803281118484,1.533209413997532,123]
["O95236-1","Apolipoprotein L3 [OS=Homo sapiens]",24,10,18,10,402,44.3,8.16,43.95,"protein metabolism;other metabolic processes;stress response;transport","non-structural extracellular;other cell component","transporter activity;other molecular function","APOL3","ENSG00000128284","","","",1302.3,1260.1,1263.1,1437.7,1525.3,1517.7,0.8537728479925011,-0.2280758127064076,2.1771674087031575E-3,2.6621081755153155,0.05431029552973166,1.265117833985452,293]
["O95239-1","Chromosome-associated kinesin KIF4A [OS=Homo sapiens]",32,33,76,33,1232,139.8,6.27,222.16,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","KIF4A","ENSG00000090889; ENSGGOG00000006631; ENSPTRG00000021996","","MHC class II antigen presentation; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","Retinoblastoma gene in cancer",6663.1,6432.2,6788.6,5325.5,5550,5923.6,1.1836288848807377,0.2432168091180418,7.1883266601739035E-3,2.143372195407318,0.09587496269929026,1.0182947920077143,548]
["O95243","Methyl-CpG-binding domain protein 4 [OS=Homo sapiens]",24,11,15,1,580,66,8.82,29.4,"DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus","nucleic acid binding activity;other molecular function","MBD4","ENSG00000129071","Base excision repair","Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Displacement of DNA glycosylase by APEX1","Base excision repair; DNA repair pathways, full network",1654.7,1696.5,1719.3,2233.3,2174.8,2735.7,0.7097763095271424,-0.49456367306400456,0.01814063135655014,1.7413476020667547,0.14474877138103162,0.8393851138506321,916]
["O95243-2","Isoform 2 of Methyl-CpG-binding domain protein 4 [OS=Homo sapiens]",24,11,15,1,574,65.3,8.84,29.64,"","","","MBD4","","","","",174,167.2,176.4,164.8,192.8,122.9,1.0772112382934445,0.10730118633139495,0.5788231647840837,0.2374540965291758,0.7088837988282285,0.1494249491098152,5968]
["O95248-1","Myotubularin-related protein 5 [OS=Homo sapiens]",26,36,70,36,1867,208.2,6.9,212.66,"","","","","","","","",5681.1,5739.2,5921.4,5126.6,5074.6,8227.3,0.941026128008248,-0.08769331430908994,0.7462764499543282,0.12710026307779287,0.8282014231272676,0.08186402756970888,6586]
["O95249-1","Golgi SNAP receptor complex member 1 [OS=Homo sapiens]",24,7,11,7,250,28.6,9.42,33.73,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","GOSR1","ENSG00000108587","SNARE interactions in vesicular transport","Intra-Golgi traffic; COPI-mediated anterograde transport","",1580.4,1636.2,1495.5,1982.7,1958.6,1478.4,0.8694392678561543,-0.20184283908962994,0.23587473836241438,0.6273185685559903,0.47401937384957016,0.3242039077267293,3637]
["O95251-1","Histone acetyltransferase KAT7 [OS=Homo sapiens]",9,7,13,7,611,70.6,8.85,30.93,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","KAT7","ENSAMEG00000012243; ENSANAG00000032052; ENSCANG00000040077; ENSCATG00000030056; ENSCJAG00000007037; ENSDLEG00000005028; ENSECAG00000010150; ENSG00000136504; ENSGGOG00000007469; ENSMLEG00000043692; ENSMNEG00000044419; ENSPANG00000022824; ENSPCTG00005022544; ENSPPAG00000041097; ENSPPYG00000008925; ENSPTRG00000009383; ENSRFEG00010021504","","HATs acetylate histones","Androgen receptor signaling pathway; Androgen receptor signaling pathway",1506.9,1493.9,1422.6,1739,1705.1,1827.9,0.8390364188163884,-0.2531946619272795,3.2782781383902536E-3,2.484354202430042,0.0663737809238071,1.1780034424517267,361]
["O95260","Arginyl-tRNA--protein transferase 1 [OS=Homo sapiens]",22,8,18,8,518,59.1,7.93,49.56,"protein metabolism;other metabolic processes","nucleus;other cell component","other molecular function","ATE1","ENSG00000107669","","","",936,940.4,908.2,944.3,990.5,965.2,0.9602068965517243,-0.05858279689831088,0.08305441756107437,1.0806372630154133,0.2953988992476363,0.5295911273435283,2055]
["O95263-4","Isoform 4 of High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [OS=Homo sapiens]",1,1,2,1,865,96.7,6.83,1.82,"","","","PDE8B","","","","",156.5,128.8,176.3,138.1,132.6,46.3,1.4561514195583596,0.5421603836187129,0.21520184111282437,0.6671540174772106,0.456577723278268,0.3404852818368822,3445]
["O95271","Tankyrase-1 [OS=Homo sapiens]",1,1,1,1,1327,142,7.05,0,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","TNKS","ENSG00000173273","","Degradation of AXIN; Ub-specific processing proteases; Regulation of PTEN stability and activity; XAV939 stabilizes AXIN","NAD+ biosynthetic pathways; Regulation of Wnt / B-catenin signaling by small molecule compounds",55,59.2,43.6,44,56,77.3,0.8900169204737732,-0.16809533088523015,0.5795506936954957,0.2369085700035499,0.7095370218124586,0.14902493924894608,5970]
["O95273-1","Cyclin-D1-binding protein 1 [OS=Homo sapiens]",8,3,8,3,360,40.2,4.82,20.1,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","","CCNDBP1","ENSG00000166946","","","",617.8,575.6,566.8,509.4,526,410.2,1.2176258992805755,0.2840709508514893,0.05641611219684207,1.248596845682159,0.24825127275539954,0.6051085162495806,1661]
["O95292","Vesicle-associated membrane protein-associated protein B/C [OS=Homo sapiens]",44,10,36,9,243,27.2,7.3,130.67,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","VAPB","ENSG00000124164","Cholesterol metabolism; Amyotrophic lateral sclerosis; Pathways of neurodegeneration","RHOA GTPase cycle; Sphingolipid de novo biosynthesis; RHOC GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOD GTPase cycle","Ciliary landscape",5083.4,5275.3,5043,5028,5651.5,3906.3,1.0559379670638567,0.07852508352396723,0.6257630337959366,0.20359009586004637,0.7438123294868272,0.12853662702072174,6149]
["O95295","SNARE-associated protein Snapin [OS=Homo sapiens]",14,2,4,2,136,14.9,9.31,12.19,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SNAPIN","ENSG00000143553","","Golgi Associated Vesicle Biogenesis","",124.4,118.4,127.5,138.7,204.6,292,0.582874232645994,-0.7787434696291585,0.11799501584610783,0.9281363370688597,0.3469129407961392,0.4597794994905127,2486]
["O95297-1","Myelin protein zero-like protein 1 [OS=Homo sapiens]",3,1,2,1,269,29.1,8.72,4.69,"cell-cell signaling;signal transduction","plasma membrane;other membranes","other molecular function","MPZL1","ENSG00000197965","Cell adhesion molecules","","",409.8,353.5,440,391.6,390,223.7,1.1969561324977618,0.25937027961003783,0.34151728217369315,0.46658731434625195,0.5539613438543106,0.25652053985009093,4506]
["O95298-1","NADH dehydrogenase [ubiquinone] 1 subunit C2 [OS=Homo sapiens]",30,5,22,5,119,14.2,8.98,49.67,"cell organization and biogenesis;other metabolic processes;transport","plasma membrane;other membranes;mitochondrion;other cytoplasmic organelle;other cell component","transporter activity","NDUFC2","ENSG00000151366; ENSGGOG00000041901","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Neutrophil degranulation; Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",3009,2536.2,2366.9,2414.3,3329.6,2422.1,0.9689076659319129,-0.045568907316345345,0.8254286916588528,0.08332043924761422,0.8812530393418865,0.054899372165499546,6846]
["O95299","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [OS=Homo sapiens]",35,10,24,10,355,40.7,8.48,57.68,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;other cell component","transporter activity","NDUFA10","ENSG00000130414","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",2380.5,2337.9,2361.1,2313.7,2151,1836.9,1.1234448394058654,0.167929290633311,0.1386497855346229,0.858080797858221,0.37505228810975527,0.42590818066025987,2702]
["O95319-1","CUGBP Elav-like family member 2 [OS=Homo sapiens]",17,9,36,8,508,54.3,8.76,79.13,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","CELF2","ENSANAG00000024646; ENSCATG00000032144; ENSG00000048740; ENSPANG00000023401; ENSPPYG00000002083; ENSSBOG00000028844","","","mRNA processing",4534.7,4512.6,4802.7,4932.1,4745.6,3931.1,1.0177238257598025,0.02534611813023468,0.8146586301406011,0.08902433739972586,0.8744808235713987,0.05824970969409592,6809]
["O95336","6-phosphogluconolactonase [OS=Homo sapiens]",38,6,21,6,258,27.5,6.05,60.85,"other metabolic processes","cytosol;other cell component","other molecular function","PGLS","ENSG00000130313","Pentose phosphate pathway; Metabolic pathways; Carbon metabolism","Pentose phosphate pathway","Pentose phosphate metabolism",1410.5,1437.3,1408.5,1278.8,1449.5,1581.1,0.9876780990393096,-0.017887175132192262,0.8504068638709923,0.0703732431587173,0.8979520034719853,0.04674687623285326,6922]
["O95340","bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [OS=Homo sapiens]",29,15,34,13,614,69.5,8.03,114.36,"other metabolic processes;developmental processes","cytosol","kinase activity;other molecular function","PAPSS2","ENSG00000198682","Purine metabolism; Selenocompound metabolism; Sulfur metabolism; Metabolic pathways","Transport and synthesis of PAPS; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se; Defective PAPSS2 causes SEMD-PA","RANKL/RANK signaling pathway; Proteoglycan biosynthesis; Sulfation biotransformation reaction",3356.7,3255.7,3277,3110.3,3173.4,3454.9,1.0154847719384716,0.02216860535186617,0.6722232082550338,0.17248649775302877,0.7753320860243084,0.11051224299429538,6337]
["O95347-1","structural maintenance of chromosomes protein 2 [OS=Homo sapiens]",48,65,205,65,1197,135.6,8.43,553.65,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMC2; SMC2L1","ENSG00000136824","","Condensation of Prophase Chromosomes; Condensation of Prometaphase Chromosomes","Retinoblastoma gene in cancer",26230.5,25651.2,25856.5,25197.5,25235.8,21413.2,1.082003994627435,0.11370582542956402,0.19950378485853815,0.700048860741214,0.44026967497918335,0.35628122697008363,3312]
["O95352","Ubiquitin-like modifier-activating enzyme ATG7 [OS=Homo sapiens]",6,3,3,3,703,77.9,6.24,2.83,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;cytosol;cytoskeleton;other cell component","other molecular function","ATG7","ENSG00000197548","Autophagy; Autophagy; Ferroptosis; Neutrophil extracellular trap formation","Neutrophil degranulation; Antigen processing: Ubiquitination & Proteasome degradation; Signaling by BRAF and RAF1 fusions; Macroautophagy","Nanoparticle triggered autophagic cell death; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Senescence and autophagy in cancer",63.7,50.2,52.4,55.8,66.6,49.9,0.9651770168311087,-0.0511345329376789,0.7714385531625313,0.11269866076767165,0.8447107692981185,0.07329196892031153,6675]
["O95359","Transforming acidic coiled-coil-containing protein 2 [OS=Homo sapiens]",1,4,12,1,2948,309.2,4.79,28.04,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","TACC2","ENSG00000138162","","","",60.8,59.9,66,62.6,57,34,1.2154947916666667,0.2815437115050459,0.28537967947534837,0.544576954157302,0.5173214477394149,0.2862395157107979,4032]
["O95363","phenylalanine--tRNA ligase, mitochondrial [OS=Homo sapiens]",7,3,6,3,451,52.3,7.46,19.74,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","FARS2","ENSG00000145982","Aminoacyl-tRNA biosynthesis","Mitochondrial tRNA aminoacylation","",958.2,1006.8,981.5,986,922.1,1049,0.9964154069865747,-0.005180765589544733,0.932562225386239,0.03032218017314886,0.9555723125400282,0.019736442309859124,7133]
["O95365","Zinc finger and BTB domain-containing protein 7A [OS=Homo sapiens]",11,3,4,3,584,61.4,5.19,20.38,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB7A","ENSG00000178951","","","IL-18 signaling pathway",89.9,81.6,101.3,110.5,105,441.6,0.4151575102724091,-1.268269297762062,0.3144103183081023,0.5025032097358775,0.5383052275741204,0.26897140265585123,4269]
["O95372","acyl-protein thioesterase 2 [OS=Homo sapiens]",29,5,22,5,231,24.7,7.23,67.04,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes","cytosol;ER/Golgi;other cell component","other molecular function","LYPLA2","ENSG00000011009","Glycerophospholipid metabolism","L1CAM interactions","",2832.1,2738.7,2919.6,2578.5,2839.4,3622.7,0.939141207441984,-0.09058599988360261,0.5951064199299361,0.22540536459807506,0.7204957467728843,0.14236857856757507,6037]
["O95373","Importin-7 [OS=Homo sapiens]",36,27,146,26,1038,119.4,4.82,481.3,"stress response;transport;signal transduction;other biological processes","cytosol;nucleus","transporter activity;enzyme regulator activity;other molecular function","IPO7","ENSG00000205339","Nucleocytoplasmic transport","","",13764.5,14369.6,14526.9,13352.1,12832.8,13001.7,1.0886629613184098,0.12255737986309453,0.014111555683338422,1.8504251061997943,0.12892670061190065,0.8896571313077649,800]
["O95376","E3 ubiquitin-protein ligase ARIH2 [OS=Homo sapiens]",25,9,23,9,493,57.8,5.63,62.16,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","other molecular function","ARIH2","ENSG00000177479","","Antigen processing: Ubiquitination & Proteasome degradation","Modulators of TCR signaling and T cell activation",1271.2,1265.5,1340.6,1311.3,1263.7,1596.6,0.929451529389203,-0.10554846388264204,0.40995963536686225,0.38725890181786515,0.5931106442787799,0.22686428181718538,5052]
["O95379","Tumor necrosis factor alpha-induced protein 8 [OS=Homo sapiens]",24,4,10,4,198,23,7.93,27.88,"other biological processes","nucleus;other cell component","enzyme regulator activity","TNFAIP8","ENSG00000145779","","PI Metabolism","",235.5,221.8,207.8,246.4,301.5,73.8,1.0698085893517775,0.09735269205101797,0.8442905388111305,0.07350807743901552,0.8935591584376705,0.04887668956847799,6906]
["O95391","Pre-mRNA-splicing factor SLU7 [OS=Homo sapiens]",16,8,13,8,586,68.3,7.14,34.85,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SLU7","ENSG00000164609","Spliceosome","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway","",634.1,655.5,604.4,971.9,921.8,1091.9,0.6343783494105039,-0.6565845604960111,2.2909511211924205E-3,2.639984176643368,0.05508079521314277,1.258999798368149,304]
["O95394","phosphoacetylglucosamine mutase [OS=Homo sapiens]",23,14,33,14,542,59.8,6.25,91.25,"protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol","other molecular function","PGM3","ENSG00000013375","Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars","Synthesis of UDP-N-acetyl-glucosamine","Glucuronidation",4828,5234.1,5696.6,5312,4315.6,2833,1.2646822785419642,0.3387749874926907,0.2228931983882641,0.6519031838639248,0.4642708426958741,0.33322859019535805,3509]
["O95396","Adenylyltransferase and sulfurtransferase MOCS3 [OS=Homo sapiens]",14,6,11,6,460,49.6,6.21,33.72,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;other cell component","other molecular function","MOCS3","ENSG00000124217","Sulfur relay system","Molybdenum cofactor biosynthesis","",1101.8,1080.2,1099.6,1097.1,1073.9,956,1.0494403581707707,0.06962017766744925,0.3086084858102438,0.5105921363095038,0.535014094588964,0.271634776630021,4216]
["O95400","CD2 antigen cytoplasmic tail-binding protein 2 [OS=Homo sapiens]",50,10,33,10,341,37.6,4.61,102.7,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","CD2BP2","ENSG00000169217","","mRNA Splicing - Major Pathway","mRNA processing; Ciliary landscape",2089.4,2041.6,1866.9,2214,2251.9,2548.7,0.8550594474382004,-0.22590336899075025,0.05416735148498837,1.2662623987412953,0.24423761382096237,0.6121874517058372,1621]
["O95425","Supervillin [OS=Homo sapiens]",1,2,2,2,2214,247.6,6.98,2.04,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","SVIL","ENSG00000197321","","","",268.9,242.7,265.7,238.3,246.5,64,1.416362973760933,0.5021910347284382,0.2736798734434712,0.562757139651753,0.5084713256223516,0.2937335333510979,3934]
["O95427","GPI ethanolamine phosphate transferase 1 [OS=Homo sapiens]",2,2,2,2,931,105.7,8.65,5.83,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;ER/Golgi","other molecular function","PIGN","ENSG00000197563","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways","Synthesis of glycosylphosphatidylinositol (GPI)","",224,234.8,255.4,227.5,234.3,316.6,0.9175231243576567,-0.12418357619504598,0.5160890183961563,0.28727538196994873,0.6662124047081431,0.17638728511505994,5662]
["O95433","activator of 90 kDa heat shock protein ATPase homolog 1 [OS=Homo sapiens]",71,19,101,19,338,38.3,5.53,313.06,"other biological processes","cytosol;ER/Golgi","other molecular function","AHSA1","ENSG00000100591","","","T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection",11988.6,12412.7,12664.8,12479.5,11762.3,13363.3,0.9856668377427532,-0.02082800686325695,0.7391381016123224,0.13127440982607777,0.8235305464458025,0.0843202873177651,6560]
["O95453","poly(A)-specific ribonuclease PARN [OS=Homo sapiens]",26,16,30,16,639,73.4,6.2,64.2,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PARN","ENSG00000140694; ENSG00000274829","RNA degradation","Deadenylation of mRNA; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA","Lung fibrosis",2404.2,2710,2403.6,2446.3,2346.3,2285.3,1.0621512030404496,0.08698915630137372,0.2617070953304593,0.5821845027285045,0.49761112376959604,0.30310991984103935,3844]
["O95456","Proteasome assembly chaperone 1 [OS=Homo sapiens]",48,9,19,9,288,32.8,7.17,59.26,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes","cytosol;ER/Golgi;nucleus;other cell component","other molecular function","PSMG1","ENSG00000183527","","","",1544.9,1608.4,1705.6,1557.1,1473.4,791.7,1.2712312280885354,0.3462264703710474,0.23413274401547476,0.6305378449501022,0.4723367998921074,0.32574821710066604,3623]
["O95461-1","LARGE xylosyl- and glucuronyltransferase 1 [OS=Homo sapiens]",5,4,6,3,756,88,7.84,7.11,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","LARGE; LARGE1","ENSG00000133424; ENSPTRG00000014294","Mannose type O-glycan biosynthesis; Metabolic pathways","Defective LARGE causes MDDGA6 and MDDGB6; O-linked glycosylation","",138.8,113.2,121.3,115.9,116.4,174,0.9187792271720404,-0.12220985592801809,0.6234550518466215,0.20519485162993467,0.7417927680200157,0.12971740506552507,6143]
["O95466-2","Isoform 2 of Formin-like protein 1 [OS=Homo sapiens]",42,47,196,5,1104,122.3,5.83,583.57,"","","","FMNL1","","","","",23719.7,23194.1,23225.9,21633.8,22308.1,22747.6,1.051735280666372,0.07277162732160329,0.034734697471537,1.459236479343657,0.19320845039533024,0.7139738826834459,1314]
["O95470","sphingosine-1-phosphate lyase 1 [OS=Homo sapiens]",5,3,8,3,568,63.5,9.16,14.54,"other metabolic processes;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","SGPL1","ENSG00000166224","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway","Sphingolipid de novo biosynthesis","Sphingolipid pathway; Kennedy pathway from sphingolipids; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway",636.2,659.1,678.8,597.9,558.2,338.6,1.3207332575098685,0.40133912144766365,0.12168438422703229,0.9147651512618774,0.35251334297082004,0.45282443989547905,2523]
["O95476","CTD nuclear envelope phosphatase 1 [OS=Homo sapiens]",4,1,1,1,244,28.4,9.76,3.48,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","CTDNEP1","ENSG00000175826; ENSG00000288307","","Depolymerisation of the Nuclear Lamina","Development of ureteric collection system",161.6,160.2,164.6,144.7,164.4,125,1.1204791522690623,0.16411580619070448,0.20245367453659238,0.6936743363740397,0.44369832299488865,0.35291221274263457,3335]
["O95478","Ribosome biogenesis protein NSA2 homolog [OS=Homo sapiens]",26,6,10,6,260,30,10.27,28.21,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","NSA2","ENSG00000164346","","","",834.2,831.9,892.6,2118.4,1893.5,2250.7,0.40856832625427136,-1.2913507296000903,3.1216566270748491E-4,3.505614869745087,0.024800204660097903,1.6055447352066694,92]
["O95479","GDH/6PGL endoplasmic bifunctional protein [OS=Homo sapiens]",3,2,2,2,791,88.8,7.3,6.86,"other metabolic processes;other biological processes","mitochondrion;ER/Golgi","other molecular function","H6PD","ENSG00000049239","Pentose phosphate pathway; Metabolic pathways; Carbon metabolism","","Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism",93.6,109.2,125,78.6,87.6,236.5,0.8140054631239136,-0.29688961784629514,0.6561849913119748,0.18297370730098225,0.7644335514024903,0.11666025977873554,6274]
["O95486-1","Protein transport protein Sec24A [OS=Homo sapiens]",9,9,26,9,1093,119.7,7.66,77.11,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi","other molecular function","SEC24A","ENSG00000113615","Protein processing in endoplasmic reticulum; Pathogenic Escherichia coli infection","MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Sterol regulatory element-binding proteins (SREBP) signaling",1979.8,2103.8,2092.8,2292.8,2132.7,2255.6,0.9244585472452143,-0.11331946430552796,0.054639768407079126,1.2624911500977671,0.24425814512987237,0.6121509452100992,1635]
["O95487-1","Protein transport protein Sec24B [OS=Homo sapiens]",13,13,27,13,1268,137.3,6.67,85.07,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","SEC24B","ENSG00000138802","Protein processing in endoplasmic reticulum; Pathogenic Escherichia coli infection","COPII-mediated vesicle transport; MHC class II antigen presentation; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Sterol regulatory element-binding proteins (SREBP) signaling",2106.4,2216.5,2236,2329.4,2196.8,2879.7,0.8856317260562522,-0.1752211900621805,0.2554974362042995,0.5926134534467318,0.49220631555540983,0.30785281811540255,3794]
["O95503","Chromobox protein homolog 6 [OS=Homo sapiens]",2,1,1,1,412,43.9,10.01,2.47,"cell organization and biogenesis;other biological processes","nucleus;other cell component","","CBX6","ENSG00000183741","","Regulation of PTEN gene transcription; Oxidative Stress Induced Senescence; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","",53.2,52.9,49.9,250.5,265.5,195.1,0.21937842778793418,-2.188506427184038,9.9028448175791212E-4,3.0042400265036084,0.03933689824548141,1.4051998876291723,184]
["O95544","NAD kinase [OS=Homo sapiens]",7,2,3,2,446,49.2,6.47,11.27,"other metabolic processes;other biological processes","cytosol","kinase activity;other molecular function","NADK","ENSG00000008130","Nicotinate and nicotinamide metabolism; Metabolic pathways; Biosynthesis of cofactors","Nicotinate metabolism","NAD+ metabolism",202.4,211.2,254.9,266,220.1,432.5,0.7277378619638581,-0.45850922324022875,0.2784678505300809,0.5552249374501655,0.5120305709495249,0.2907041085586816,3975]
["O95551-1","Tyrosyl-DNA phosphodiesterase 2 [OS=Homo sapiens]",21,5,10,5,362,40.9,5.1,40.15,"DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TDP2","ENSG00000111802","","Nonhomologous End-Joining (NHEJ)","Oxidative damage response",846.5,854.3,764.4,1262.3,1310.1,1721.3,0.5741435125882106,-0.8005166976715087,0.014799605083665391,1.8297498732721522,0.13191501653232968,0.8797057637718959,820]
["O95562","Vesicle transport protein SFT2B [OS=Homo sapiens]",17,2,2,2,160,17.8,9.13,7.37,"transport","other membranes","","SFT2D2","ENSG00000213064","","","TYROBP causal network in microglia",199.6,211.7,174.2,210.4,178.2,136.5,1.1150257093886877,0.15707697506033827,0.45008523704737324,0.34670523183826063,0.6174311181642739,0.2094114861165323,5328]
["O95563","Mitochondrial pyruvate carrier 2 [OS=Homo sapiens]",28,4,16,4,127,14.3,10.43,39.48,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MPC2","ENSG00000143158","Diabetic cardiomyopathy","Pyruvate metabolism","Glycolysis and gluconeogenesis",2552.3,2403.2,2365.5,1886.3,2199,1261.4,1.3692558026446218,0.4533919942454947,0.07953544622798281,1.0994392780052238,0.2896485184256733,0.5381286886087363,2007]
["O95568","histidine protein methyltransferase 1 homolog [OS=Homo sapiens]",8,2,3,2,372,42.1,6.76,10.13,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","METTL18","ENSG00000171806","","","",119.8,122.3,130.9,151.2,167,193.2,0.7293703558858037,-0.4552765300990487,0.022113417388163276,1.6553441367457509,0.1572246767413282,0.8034792895210348,1028]
["O95571","Persulfide dioxygenase ETHE1, mitochondrial [OS=Homo sapiens]",20,4,16,4,254,27.9,6.83,64.11,"other metabolic processes","mitochondrion;nucleus;other cell component","other molecular function","ETHE1","ENSG00000105755","Sulfur metabolism; Metabolic pathways","Sulfide oxidation to sulfate","",2388.4,2519.2,2369.2,2091.7,2255.7,2730.3,1.0281306074007093,0.040023547294940336,0.7533664755055277,0.12299370962637875,0.8331601708987595,0.07927149961283589,6609]
["O95573","long-chain-fatty-acid--CoA ligase 3 [OS=Homo sapiens]",27,15,45,12,720,80.4,8.38,138.07,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ACSL3","ENSG00000123983","Fatty acid biosynthesis; Fatty acid degradation; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; Peroxisome; Ferroptosis; Thermogenesis; Adipocytokine signaling pathway","Synthesis of very long-chain fatty acyl-CoAs; Intracellular metabolism of fatty acids regulates insulin secretion","Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Ciliary landscape; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters",4275.7,4337.7,4307.4,3863.6,3917.7,4242.2,1.0746288518318292,0.10383847741778887,0.06665745772603218,1.1761512540809824,0.26710491146906207,0.5733181261894067,1824]
["O95602","DNA-directed RNA polymerase I subunit RPA1 [OS=Homo sapiens]",21,29,61,28,1720,194.7,7.03,192.23,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POLR1A","ENSG00000068654","RNA polymerase","B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","Pyrimidine metabolism; Eukaryotic transcription initiation",4279.1,4334.2,4451.1,4977.8,4693.8,5136.2,0.8822647523602426,-0.18071644635839074,0.013907258489331373,1.8567584731927373,0.12818178095652333,0.8921736986263681,793]
["O95613","Pericentrin [OS=Homo sapiens]",23,67,104,67,3336,377.8,5.55,318.42,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton","other molecular function","PCNT","ENSG00000160299","","Late endosomal microautophagy; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Chaperone Mediated Autophagy","",9239.5,8738.5,9235.3,10737.7,10715.2,9884,0.8684107234602019,-0.20355055388670584,0.013577556262652115,1.8671783889029485,0.1269032720252229,0.8965271800788236,782]
["O95619","YEATS domain-containing protein 4 [OS=Homo sapiens]",22,5,8,5,227,26.5,8.41,21.32,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","other membranes;nucleus","cytoskeletal activity;other molecular function","YEATS4","ENSG00000127337","","HATs acetylate histones; Activation of the TFAP2 (AP-2) family of transcription factors","",777,819.8,781.6,1176.8,1013.7,851.9,0.7817512490139364,-0.35521847572294674,0.07976494944018739,1.0981879057511714,0.29005075395936797,0.5375260012876873,2010]
["O95620","tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like [OS=Homo sapiens]",7,1,1,1,317,35.8,7.33,4.6,"RNA metabolism OR transcription;other metabolic processes","","other molecular function","DUS4L","ENSG00000105865; ENSG00000284103","","","",17.5,13.7,17.4,11.4,11.8,26.7,0.9739478957915829,-0.03808350173148,0.9374414154226165,0.028055863604172497,0.9585561423228741,0.01838244555380615,7148]
["O95625","Zinc finger and BTB domain-containing protein 11 [OS=Homo sapiens]",3,3,4,3,1053,119.3,8.66,12.07,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZBTB11","ENSG00000066422","","","",425.6,420.3,406.3,469.2,517.3,587.7,0.7954516579850083,-0.33015383862958453,0.03705591207157793,1.4311424928066445,0.1984187995100096,0.7024171822994463,1365]
["O95628-6","Isoform 6 of CCR4-NOT transcription complex subunit 4 [OS=Homo sapiens]",14,7,14,7,767,84.7,7.3,39.71,"","","","CNOT4","","","","",900.6,860.9,873.4,1032.5,979.5,1323.2,0.7900275845526505,-0.3400250676703471,0.09559918346244374,1.0195458171304834,0.31703014152767756,0.4988994454262579,2204]
["O95630","STAM-binding protein [OS=Homo sapiens]",21,10,22,10,424,48,6.29,53.17,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle","other molecular function","STAMBP","ENSG00000124356","Endocytosis","Metalloprotease DUBs","EGF/EGFR signaling pathway",3346.2,3727.8,3319.8,4026.2,3963,4309.2,{"$f":"AVERAGE(S834:U834)/AVERAGE(V834:X834)","v":0.8451343264164445},{"$f":"LOG(Y834,2)","v":-0.2427474320093376},{"$f":"TTEST(V834:X834,S834:U834,2,2)","v":0.019997794378811946},1.6990179014326956,{"$f":"AA834*7309/AE834","v":0.15115189153540487},0.8205864136317244,967]
["O95639","Cleavage and polyadenylation specificity factor subunit 4 [OS=Homo sapiens]",18,5,10,5,269,30.2,8.31,21.81,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CPSF4","ENSG00000160917","mRNA surveillance pathway; Influenza A","mRNA Splicing - Major Pathway; Transport of Mature mRNA Derived from an Intronless Transcript; tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Inhibition of Host mRNA Processing and RNA Silencing","mRNA processing",1090.1,1106.3,1063.1,1235.5,1197.8,788.6,1.0116701325304942,0.01673895827313697,0.9346673949119753,{"$f":"-LOG10(AA835)","v":0.029342907044732067},0.9567904747075109,{"$f":"-LOG10(AC835)","v":0.01918315693693346},7140]
["O95671-1","N-acetylserotonin O-methyltransferase-like protein [OS=Homo sapiens]",24,12,24,12,621,68.8,6.07,76.91,"other metabolic processes","cytosol","other molecular function","ASMTL","ENSG00000169093","Pyrimidine metabolism","","",2564.8,2586.6,2561.1,2241,2038.3,2061.1,1.2164059049902214,0.28262472499946006,2.1003495308756512E-3,2.6777084258856223,0.05405441803228921,1.2671688040486868,284]
["O95674-1","phosphatidate cytidylyltransferase 2 [OS=Homo sapiens]",31,9,25,8,445,51.4,7.09,87.87,"cell organization and biogenesis;other metabolic processes","other membranes;mitochondrion;ER/Golgi","other molecular function","CDS2","ENSG00000101290","Glycerophospholipid metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of PG","",1876.5,1998.7,1974.7,1898.8,1987.2,2023.5,0.9899145443776969,-0.01462410678984923,0.7249302201157182,0.13970379546650355,0.8141541147550375,0.08929337784735178,6508]
["O95684","FGFR1 oncogene partner [OS=Homo sapiens]",34,7,10,7,399,43,4.81,32.64,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","CEP43","ENSG00000213066","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease","Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome",582.7,449.1,472.1,431.5,506.1,464.4,1.072681883024251,0.10122229060551477,0.5059798477932252,0.2958667799319117,0.6593344103263832,0.18089425805745546,5609]
["O95696","Bromodomain-containing protein 1 [OS=Homo sapiens]",5,4,5,4,1058,119.4,8.6,10.81,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","other molecular function","BRD1","ENSG00000100425","","HATs acetylate histones; Regulation of TP53 Activity through Acetylation","Pathways affected in adenoid cystic carcinoma",375.7,392.9,385.7,396.5,423.5,528.8,0.8557977461447213,-0.22465821544701103,0.18610324414757995,0.7302460561915742,0.4296363270608534,0.3668990048339384,3166]
["O95707","Ribonuclease P protein subunit p29 [OS=Homo sapiens]",12,2,3,2,220,25.4,10.07,9.23,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POP4","ENSG00000105171","Ribosome biogenesis in eukaryotes","tRNA processing in the nucleus","",138.3,150.6,167.8,164.1,156.1,164.4,0.9424267437061493,-0.08554761507299241,0.35870081161692563,0.44526764066344393,0.5644228702062668,0.24839539710913155,4645]
["O95714","E3 ubiquitin-protein ligase HERC2 [OS=Homo sapiens]",4,14,22,14,4834,526.9,6.28,62.99,"protein metabolism;DNA metabolism;other metabolic processes;stress response;transport","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","HERC2","ENSG00000128731","Ubiquitin mediated proteolysis","SUMOylation of DNA damage response and repair proteins; Antigen processing: Ubiquitination & Proteasome degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)","Prader-Willi and Angelman syndrome",1250,1204,1250.8,1443.4,1392.7,1602.6,0.8346587964944691,-0.260741541859488,0.01981071044568092,1.7030999496453794,0.1503597950648825,0.8228682748859408,963]
["O95716","ras-related protein Rab-3D [OS=Homo sapiens]",31,7,25,4,219,24.3,4.93,56.46,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB3D","ENSG00000105514","Pancreatic secretion","Neutrophil degranulation; RAB geranylgeranylation","",1052.9,1123.4,1098.2,1021.7,1067.2,958.1,1.07466360354447,0.10388513102546182,0.11507688001885748,0.9390119212773844,0.3437257523734488,0.4637879287452006,2447]
["O95721","Synaptosomal-associated protein 29 [OS=Homo sapiens]",22,6,7,6,258,29,5.81,17.87,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","SNAP29","ENSG00000099940","SNARE interactions in vesicular transport; Autophagy","Intra-Golgi traffic; Neutrophil degranulation","Ciliary landscape; 22q11.2 copy number variation syndrome",1006.2,917.8,956.3,1131.8,1162.4,1261.6,0.81002868552787,-0.30395509585797525,0.008572721842820328,2.0668812675001447,0.10288673883279766,0.9876405982490469,609]
["O95747","Serine/threonine-protein kinase OSR1 [OS=Homo sapiens]",31,13,59,11,527,58,6.43,200.91,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol","kinase activity;other molecular function","OXSR1","ENSG00000172939","","","",4786.7,4814.4,4758.6,4489.1,4383.1,4095.8,1.1073180135718692,0.14706961300949403,0.017366117681441327,1.7602972603081903,0.14229703378212405,0.8468041528003405,892]
["O95749","geranylgeranyl pyrophosphate synthase [OS=Homo sapiens]",12,4,7,4,300,34.8,6.14,18.08,"other metabolic processes","cytosol","other molecular function","GGPS1","ENSG00000152904","Terpenoid backbone biosynthesis; Metabolic pathways","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways",1050.7,966.4,1006.4,997.2,1042.3,557.9,1.164048664048664,0.21915137260540382,0.4151855952187623,0.3817577226584598,0.5947846953065334,0.2256402150482581,5102]
["O95757","Heat shock 70 kDa protein 4L [OS=Homo sapiens]",56,41,192,36,839,94.5,5.88,590.57,"stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","HSPA4L","ENSG00000164070","Protein processing in endoplasmic reticulum","Regulation of HSF1-mediated heat shock response","",17419.4,17383.7,17684.1,18043.3,18086.7,13930.3,1.0484795336823791,0.06829870030611725,0.5896195879452217,0.22942809707028344,0.716821285477649,0.144589107101181,6012]
["O95758-1","Isoform 1 of Polypyrimidine tract-binding protein 3 [OS=Homo sapiens]",17,8,57,3,521,56.5,9.22,133.39,"","","","PTBP3","","","","",1173.3,1203.4,1149,1111,1324.3,3166,0.6294431649795583,-0.6678519779500431,0.3488077872298533,0.4574138278873981,0.5581077313623024,0.2532819612412168,4568]
["O95772-1","STARD3 N-terminal-like protein [OS=Homo sapiens]",7,2,3,2,234,26.6,4.81,4.26,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","STARD3NL","ENSCANG00000042172; ENSCATG00000036966; ENSCSAG00000015104; ENSG00000010270; ENSGGOG00000013471; ENSMFAG00000043802; ENSMLEG00000030425; ENSMMUG00000023659; ENSMNEG00000034363; ENSPANG00000016262; ENSPPAG00000039214; ENSPTRG00000019094; ENSRBIG00000036179; ENSRROG00000026971","","Pregnenolone biosynthesis","",551.9,554.2,576.4,562,544.8,501.1,1.0463959201442876,0.06542882094951388,0.27622586340009997,0.5587356602755589,0.50983202918973,0.2925728843170982,3960]
["O95777","U6 snRNA-associated Sm-like protein LSm8 [OS=Homo sapiens]",59,4,23,4,96,10.4,4.48,78.7,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","LSM8","ENSG00000128534","RNA degradation; Spliceosome","mRNA Splicing - Major Pathway","",952.7,910.4,938,949.3,944.4,574.8,1.1347376949564512,0.18235884384173826,0.4240086831338732,0.37262524954284854,0.6003640962854474,0.2215852878667256,5162]
["O95782","AP-2 complex subunit alpha-1 [OS=Homo sapiens]",38,32,95,22,977,107.5,7.03,261.06,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","AP2A1","ENSG00000196961","Endocytosis; Synaptic vesicle cycle; Endocrine and other factor-regulated calcium reabsorption; Huntington disease","MHC class II antigen presentation; Recycling pathway of L1; Potential therapeutics for SARS; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Trafficking of GluR2-containing AMPA receptors; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation","Synaptic vesicle pathway; VEGFA-VEGFR2 signaling pathway; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; mBDNF and proBDNF regulation of GABA neurotransmission",10845.8,11033.3,11374,10116.4,10056.4,11456.9,1.0513251785505398,0.07220896894088422,0.32492585630410886,0.48821572785663137,0.5444482080987463,0.26404342721533997,4362]
["O95785-3","Isoform 3 of Protein Wiz [OS=Homo sapiens]",14,8,13,8,965,102.9,9.52,28.55,"","","","WIZ","","","","",505.8,462.5,515.3,553.4,560.3,717.5,0.8101791175185671,-0.30368719505267694,0.10733084809709623,0.9692754389574937,0.3336797825358045,0.47667010619846006,2351]
["O95793","double-stranded RNA-binding protein Staufen homolog 1 [OS=Homo sapiens]",12,6,9,6,577,63.1,9.44,22.2,"cell organization and biogenesis;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","nucleic acid binding activity;other molecular function","STAU1","ENSG00000124214","","","",653.6,610,608.7,764.5,765.9,685.8,0.8448244743254221,-0.24327646511942294,0.019389888480773408,1.712424688720367,0.14871006810700194,0.8276596274747203,953]
["O95801","Tetratricopeptide repeat protein 4 [OS=Homo sapiens]",36,10,23,10,387,44.7,5.6,68.81,"stress response","nucleus;other cell component","other molecular function","TTC4","ENSG00000243725","","","",2248.3,2260.4,2258.9,3270.8,3444.9,2597.3,0.7266831311070546,-0.46060167824545556,0.030427897890806493,1.5167280498093445,0.1841038954336959,0.7349370222104845,1208]
["O95816","BAG family molecular chaperone regulator 2 [OS=Homo sapiens]",33,8,15,8,211,23.8,6.7,43.88,"protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","BAG2","ENSG00000112208","Protein processing in endoplasmic reticulum","Regulation of HSF1-mediated heat shock response","Malignant pleural mesothelioma",1535.3,1389.2,1383.8,1806.5,1986.7,1400.3,0.8295561759892174,-0.26958841379435244,0.17721970771097917,0.7514879840617632,0.4193262685851559,0.37744793047924097,3089]
["O95817","BAG family molecular chaperone regulator 3 [OS=Homo sapiens]",4,2,3,2,575,61.6,6.95,7.24,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","BAG3","ENSG00000151929","","Regulation of HSF1-mediated heat shock response","",158.9,135.1,179.7,142.6,86.3,252.2,0.9846185824152984,-0.022363127500828382,0.96329993462576,0.016238469187179444,0.9749043508972142,0.01103799139401425,7222]
["O95819","Mitogen-activated protein kinase kinase kinase kinase 4 [OS=Homo sapiens]",7,7,7,4,1239,142,7.46,21.82,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","other cell component","cytoskeletal activity;kinase activity;other molecular function","MAP4K4","ENSG00000071054","MAPK signaling pathway","Oxidative Stress Induced Senescence","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Insulin signaling; Malignant pleural mesothelioma",241.3,235.9,238.4,234.4,248,323.2,0.8882820258192652,-0.1709102959548764,0.3390655953147045,0.469716275462296,0.5524365662405651,0.25771758282527196,4486]
["O95822","Malonyl-CoA decarboxylase, mitochondrial [OS=Homo sapiens]",18,6,6,6,493,55,8.95,22.43,"other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","MLYCD","ENSG00000103150","beta-Alanine metabolism; Propanoate metabolism; Metabolic pathways; Peroxisome; AMPK signaling pathway; Alcoholic liver disease","","",501.2,467.4,458.3,450,466.9,891.2,0.7891709529340191,-0.3415902392177471,0.43009910179223637,0.3664314644142473,0.6047699759521846,0.21840977769526812,5198]
["O95825-1","Quinone oxidoreductase-like protein 1 [OS=Homo sapiens]",11,2,3,2,349,38.7,5.78,10.21,"other metabolic processes","","other molecular function","CRYZL1","ENSG00000205758","","","",226.3,254.6,265.7,236.9,234,141.4,1.2193369263432956,0.2860968255491943,0.25219354566817664,0.5982660324202101,0.4888047269394598,0.31086460294185747,3771]
["O95831-1","Apoptosis-inducing factor 1, mitochondrial [OS=Homo sapiens]",47,23,87,23,613,66.9,8.95,288.87,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","AIFM1","ENSG00000156709","Apoptosis; Necroptosis","","Apoptosis modulation and signaling; Nanomaterial induced apoptosis; Apoptosis modulation by HSP70",9754.5,9784.8,9910.7,9088.5,8936.1,7357.7,1.1602573446850757,0.21444483011504087,0.07109094038169539,1.1481857409429534,0.2741971943270774,0.5619369933630717,1895]
["O95834-3","Isoform 3 of Echinoderm microtubule-associated protein-like 2 [OS=Homo sapiens]",14,12,29,12,850,92,7.06,75.05,"","","","EML2","","","","",3338.6,3490,3527.4,3489,3410.4,3541.9,0.9918305191882238,-0.011834476307421916,0.7022778602493884,0.1534910227742043,0.7982813189055645,0.09784403381445342,6430]
["O95835","Serine/threonine-protein kinase LATS1 [OS=Homo sapiens]",1,1,1,1,1130,126.8,8.7,3.38,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","LATS1","ENSG00000131023","Hippo signaling pathway; Hippo signaling pathway","Signaling by Hippo","Mesodermal commitment pathway; Transcription co-factors SKI and SKIL protein partners; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Overview of leukocyte-intrinsic Hippo pathway functions; Malignant pleural mesothelioma",21.9,21.5,22.6,27.8,21.3,48.6,0.67553735926305,-0.5658925377225698,0.2689687641440666,0.5702981525163136,0.5049814274669877,0.2967245943505024,3893]
["O95841","Angiopoietin-related protein 1 [OS=Homo sapiens]",2,1,1,1,491,56.7,8.21,0,"developmental processes;signal transduction","non-structural extracellular;extracellular matrix","signal transduction activity or receptor binding","ANGPTL1","ENSG00000116194","","","RAC1/PAK1/p38/MMP2 pathway",56.6,56.1,54,54.7,48.9,58,1.031559405940594,0.04482690623462186,0.5734451704521916,0.2415081005323978,0.7050144240260838,0.1518019976031352,5945]
["O95848","uridine diphosphate glucose pyrophosphatase [OS=Homo sapiens]",7,1,1,1,222,24.1,5.05,3.49,"protein metabolism;other metabolic processes","cytosol","other molecular function","NUDT14","ENSG00000183828","","Synthesis of dolichyl-phosphate-glucose","",32.2,38.3,41.1,42,36.2,57.5,0.8224023581429625,-0.2820836935896665,0.3077628498051938,0.5117838052269104,0.5348166117988972,0.2717951116932397,4206]
["O95861-1","3'(2'),5'-bisphosphate nucleotidase 1 [OS=Homo sapiens]",60,14,59,13,308,33.4,5.69,154.82,"other metabolic processes;developmental processes","cytosol","other molecular function","BPNT1; HEL20","ENSG00000162813; ENSPTRG00000001996","Sulfur metabolism; Metabolic pathways","Cytosolic sulfonation of small molecules","",6257.9,6138.2,6312.2,5863,5608.1,4592.2,1.1646610596826306,0.21991016203763633,0.08747329829829516,1.0581244975086608,0.30329332887203003,0.5181371421651968,2108]
["O95865","N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 [OS=Homo sapiens]",53,12,36,11,285,29.6,6.01,135.24,"other metabolic processes;signal transduction;other biological processes","cytosol;mitochondrion","other molecular function","DDAH2","ENSG00000206395; ENSG00000213722; ENSG00000225635; ENSG00000226634; ENSG00000227317; ENSG00000228128; ENSG00000233076","","eNOS activation","Nitric oxide metabolism in cystic fibrosis",3626.6,3777.6,3718.1,3466.9,3500.3,5286.7,0.9076538897820284,-0.13978582676160484,0.5653587052844951,0.24767591626041197,0.6985979335459634,0.15577270334038826,5915]
["O95870-1","Protein ABHD16A [OS=Homo sapiens]",26,11,30,11,558,63.2,8.13,82.31,"other metabolic processes","other membranes","other molecular function","ABHD16A","ENSG00000204427; ENSG00000206403; ENSG00000224552; ENSG00000230475; ENSG00000231488; ENSG00000235676; ENSG00000236063; ENSGGOG00000009970","","","IL-18 signaling pathway",1901.6,1968.4,2014.5,1722.3,1820.7,2555.7,0.9648777608342762,-0.051581914173737316,0.8009042293690358,0.09641941293354397,0.8649244994766967,0.0630218010805381,6768]
["O95873","Uncharacterized protein C6orf47 [OS=Homo sapiens]",10,3,5,3,294,31.7,6.37,5.67,"","","","C6orf47","ENSG00000203623; ENSG00000204439; ENSG00000226103; ENSG00000226531; ENSG00000228177; ENSG00000228435; ENSG00000235360","","","",506,533.4,555.9,644.5,723.6,993.3,0.6755738121453377,-0.5658146901055443,0.07464857980179027,1.126978450365116,0.2805174651780386,0.5520400941428695,1945]
["O95881","Thioredoxin domain-containing protein 12 [OS=Homo sapiens]",30,5,11,5,172,19.2,5.4,26.41,"other biological processes","ER/Golgi","other molecular function","TXNDC12","ENSG00000117862","Glutathione metabolism; Metabolic pathways","","",1573,1448.3,1458.1,1593.5,1638,1454.6,0.9558908260600497,-0.06508223996152677,0.36960629045249055,0.4322606459866778,0.5684874530549775,0.24527911607584202,4752]
["O95900","Mitochondrial mRNA pseudouridine synthase TRUB2 [OS=Homo sapiens]",12,4,9,3,331,36.7,8.98,19.47,"RNA metabolism OR transcription;other metabolic processes;other biological processes","mitochondrion;other cell component","other molecular function","TRUB2","ENSG00000167112","","","",223.9,263.1,264.3,292.1,270.8,240.2,0.9354999377412524,-0.0961905374345466,0.4382209891070592,0.3583068252347504,0.6090430137637376,0.21535203416423476,5259]
["O95905","Protein ecdysoneless homolog [OS=Homo sapiens]",15,6,10,6,644,72.7,4.87,14.3,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","ECD","ENSG00000122882","","","",561.1,549,533.2,683.1,740.1,818.3,0.7331251394155699,-0.4478686173944588,0.007578683198988205,2.120406246754822,0.09769417196014954,1.0101313437637556,567]
["O95983-1","methyl-CpG-binding domain protein 3 [OS=Homo sapiens]",6,2,3,2,291,32.8,5.34,7.15,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MBD3","ENSG00000071655; ENSPTRG00000010209","","Potential therapeutics for SARS; HDACs deacetylate histones; Regulation of PTEN gene transcription; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation","Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome",359,298.8,310.9,424.9,477.5,172.1,0.9015355979525359,-0.1495436359800091,0.7320675202477911,0.13544886112918123,0.8193999242712259,0.0865040805202822,6530]
["O95985","DNA topoisomerase 3-beta-1 [OS=Homo sapiens]",14,8,10,8,862,96.6,8.12,22.94,"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TOP3B","ENSG00000100038","Homologous recombination; Fanconi anemia pathway","","",494.6,525.4,529.5,477.9,512.6,783.3,0.8735483143533657,-0.1950405967248355,0.4845241427643013,0.3146845781424507,0.6441227645442484,0.19103135176592745,5498]
["O95989","Diphosphoinositol polyphosphate phosphohydrolase 1 [OS=Homo sapiens]",33,5,11,5,172,19.5,6.34,27.02,"cell-cell signaling;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","NUDT3","ENSG00000272325","","Synthesis of pyrophosphates in the cytosol","",1018.3,1020.4,1036.9,1091.1,987.9,1159,0.9498455836936381,-0.07423510117719445,0.34061038540064936,0.46774211429052714,0.5532269570874103,0.2570966661818978,4500]
["O95997","Securin [OS=Homo sapiens]",11,2,2,2,202,22,6.6,5.51,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PTTG1","ENSG00000164611","Cell cycle; Oocyte meiosis; Human T-cell leukemia virus 1 infection","APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids","Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition",132.7,124.7,140.1,109.4,116.7,138.3,1.0908342480790338,0.12543190125702908,0.321019013599828,0.493469244053258,0.5416269553095898,0.2662997301225677,4332]
["O95999","B-cell lymphoma/leukemia 10 [OS=Homo sapiens]",3,1,1,1,233,26.2,5.74,2.09,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","BCL10","ENSG00000142867","NF-kappa B signaling pathway; C-type lectin receptor signaling pathway; T cell receptor signaling pathway; B cell receptor signaling pathway; Shigellosis; Tuberculosis","E3 ubiquitin ligases ubiquitinate target proteins; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling","B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Modulators of TCR signaling and T cell activation; T-cell receptor (TCR) signaling pathway",64.6,60.1,57.1,71.9,47.3,372.4,0.3698128559804719,-1.4351327161785548,0.3791249946480414,0.42121758281204463,0.5740676581484431,0.2410369197467636,4827]
["O96000","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [OS=Homo sapiens]",26,4,6,4,172,20.8,8.48,9.51,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity","NDUFB10","ENSG00000140990","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Modulators of TCR signaling and T cell activation; Oxidative phosphorylation",247,208.2,231.9,345.3,311.7,298.7,0.718949461127969,-0.4760377355478077,0.007474334088023174,2.1264274939439396,0.0975534068738596,1.010757559066167,560]
["O96005-1","Cleft lip and palate transmembrane protein 1 [OS=Homo sapiens]",33,14,54,14,669,76,6.3,171.56,"developmental processes;other biological processes","plasma membrane;other membranes;other cell component","","CLPTM1","ENSG00000104853","","","",3755,3923.3,3830.4,3384.4,3465.6,5415.3,0.9383137795243494,-0.09185764286736352,0.7240231600285395,0.14024754138334775,0.8138857700167018,0.08943654465948267,6502]
["O96006","zinc finger BED domain-containing protein 1 [OS=Homo sapiens]",1,1,1,1,694,78.1,6.1,2.51,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBED1","ENSG00000214717","","SUMOylation of chromatin organization proteins","",38.2,33.2,36,52.4,46.8,30.5,0.8280647648419431,-0.27218448626628655,0.3310983206701349,0.4800430219828856,0.5476346743104811,0.261509061661206,4419]
["O96007","molybdopterin synthase catalytic subunit [OS=Homo sapiens]",20,4,5,4,188,20.9,5.44,12.16,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","MOCS2","ENSG00000164172","Folate biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Sulfur relay system","Molybdenum cofactor biosynthesis","",386.1,428.2,421.8,500.4,472.2,245.9,1.0144439885104635,0.0206892103592364,0.946138876246853,0.024045112265214566,0.9640776587882682,0.01588798121667886,7173]
["O96008","Mitochondrial import receptor subunit TOM40 homolog [OS=Homo sapiens]",50,14,97,14,361,37.9,7.25,383.07,"cell organization and biogenesis;transport","other membranes;cytosol;mitochondrion;other cell component","transporter activity","TOMM40","ENSG00000130204","Amyotrophic lateral sclerosis; Pathways of neurodegeneration","Mitochondrial protein import; PINK1-PRKN Mediated Mitophagy","IL-18 signaling pathway",6003.4,6170,6702.2,5441.5,5074.6,5515.4,1.177406980008109,0.23561308550088625,0.019476752773998688,1.7104834483756888,0.14906344086403814,0.826628858075462,955]
["O96011-1","Peroxisomal membrane protein 11B [OS=Homo sapiens]",31,8,22,8,259,28.4,9.85,65.56,"cell organization and biogenesis;signal transduction","other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PEX11B","ENSG00000131779; ENSPPAG00000024465; ENSPTRG00000001203","Peroxisome","Class I peroxisomal membrane protein import","",2564.9,2726.1,2691.7,2543.1,2369.1,3112.4,0.994778555940483,-0.007552686620611115,0.9544417758110528,0.020250559900211566,0.9695642723284205,0.013423396288862598,7195]
["O96013-1","serine/threonine-protein kinase PAK 4 [OS=Homo sapiens]",2,1,1,1,591,64,9.73,4.48,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;ER/Golgi;other cell component","kinase activity;other molecular function","PAK4","ENSG00000130669","ErbB signaling pathway; Ras signaling pathway; Axon guidance; Focal adhesion; T cell receptor signaling pathway; Regulation of actin cytoskeleton; Human immunodeficiency virus 1 infection; MicroRNAs in cancer; Renal cell carcinoma","CDC42 GTPase cycle; RAC3 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; Activation of RAC1; RHOH GTPase cycle","Integrin-mediated cell adhesion; Focal adhesion; Ras signaling; Pancreatic adenocarcinoma pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; 22q11.2 copy number variation syndrome; Malignant pleural mesothelioma; Regulation of actin cytoskeleton; ErbB signaling pathway",127,130.2,125.9,151.7,172,269.7,0.6456016177957533,-0.631283901056387,0.1267854465521655,0.896930595388285,0.3604336168221617,0.44317471014717263,2571]
["O96017-1","Serine/threonine-protein kinase Chk2 [OS=Homo sapiens]",25,10,20,10,543,60.9,5.91,64.49,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","CHEK2","ENSG00000183765","Cell cycle; p53 signaling pathway; Cellular senescence; Human T-cell leukemia virus 1 infection","Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Regulation of TP53 Activity through Methylation; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Stabilization of p53","miRNA regulation of DNA damage response; Cell cycle; ATM signaling in development and disease ; miRNA regulation of p53 pathway in prostate cancer; DNA damage response",1144.4,1172.7,1186.1,1221.8,1123,1203.8,0.9872062221721242,-0.018576607340288962,0.6682493193394184,0.17506147493174715,0.7728218789638939,0.11192059133015922,6320]
["O96018","amyloid-beta A4 precursor protein-binding family A member 3 [OS=Homo sapiens]",14,5,7,5,575,61.4,4.94,15.3,"cell-cell signaling;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","enzyme regulator activity;other molecular function","APBA3","ENSG00000011132","","Neurexins and neuroligins","",560.6,565.2,588.1,629.5,584.2,574.5,0.9584498378257466,-0.06122516702500097,0.2615861241428716,0.5823852969227324,0.4977695863994398,0.30297164220393563,3841]
["O96019-1","Actin-like protein 6A [OS=Homo sapiens]",37,12,55,12,429,47.4,5.6,163.76,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;nucleus","other molecular function","ACTL6A","ENSCANG00000034249; ENSCATG00000017467; ENSCCAG00000029449; ENSCJAG00000013036; ENSCSAG00000013017; ENSG00000136518; ENSGGOG00000015710; ENSMFAG00000030153; ENSMMUG00000009742; ENSPANG00000024431; ENSPPAG00000031814; ENSPTRG00000023973; ENSRBIG00000036584; ENSRROG00000035215","Thermogenesis; Hepatocellular carcinoma","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines; UCH proteinases; HATs acetylate histones; DNA Damage Recognition in GG-NER","Gastric cancer network 1; Tumor suppressor activity of SMARCB1; Thermogenesis",7886.4,8490.3,7846.8,9685.1,10079.6,8348.3,0.8616476363248319,-0.21483008317859553,0.0829549896730299,1.0811574864052522,0.2954766176998906,0.529476880961058,2052]
["O96028-1","Histone-lysine N-methyltransferase NSD2 [OS=Homo sapiens]",13,14,20,14,1365,152.2,8.69,51.59,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NSD2","ENSG00000109685","Lysine degradation; Metabolic pathways; Transcriptional misregulation in cancer","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; PKMTs methylate histone lysines; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)","",1199.2,1236.1,1237.6,1394.4,1516.1,1245.2,0.8838222200832591,-0.17817189268930503,0.11240532987134957,0.9492130955388689,0.3396323092309607,0.4689910020167757,2419]
["P00156","cytochrome b [OS=Homo sapiens]",2,1,1,1,380,42.7,8.05,2.39,"other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MT-CYB","ENSG00000198727","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly",220.1,225.9,273.3,164.5,181.3,105.5,1.5938400177265675,0.6725068255544051,0.03502925255167554,1.455569129486363,0.19352139599410167,0.713271011789891,1323]
["P00167-1","Cytochrome b5 [OS=Homo sapiens]",49,5,12,5,134,15.3,4.96,47.76,"other metabolic processes;transport;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cell component","transporter activity;other molecular function","CYB5A","ENSG00000166347; ENSPTRG00000010111","","Vitamin C (ascorbate) metabolism","Oxidation by cytochrome P450",1672.8,1573.9,1428.6,2164.5,2172.5,1578.4,0.7903607532880278,-0.3394167856703858,0.1192341556173087,0.9235993195008438,0.34859297736276373,0.4576813662889085,2500]
["P00338-1","L-lactate dehydrogenase A chain [OS=Homo sapiens]",66,23,487,21,332,36.7,8.27,1452.1,"other metabolic processes;stress response;developmental processes;other biological processes","cytosol;other cell component","other molecular function","HEL-S-133P; LDHA","ENSG00000134333; ENSG00000288299","Glycolysis / Gluconeogenesis; Cysteine and methionine metabolism; Pyruvate metabolism; Propanoate metabolism; Metabolic pathways; HIF-1 signaling pathway; Glucagon signaling pathway; Central carbon metabolism in cancer","Pyruvate metabolism","Cori cycle; HIF1A and PPARG regulation of glycolysis; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling pathway; Amino acid metabolism; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - VitD3 signaling; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Orexin receptor pathway; CCL18 signaling pathway; Glycolysis and gluconeogenesis",49363.4,52509.7,52132.8,51375.8,45637.8,33748.3,1.1777582002096942,0.23604337688859797,0.21650502541659694,0.6645320185467941,0.45788056445888514,0.3392477904696768,3456]
["P00367","Glutamate dehydrogenase 1, mitochondrial [OS=Homo sapiens]",47,24,162,24,558,61.4,7.8,471.84,"other metabolic processes;other biological processes","mitochondrion;ER/Golgi;other cell component","other molecular function","GLUD1","ENSG00000148672","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Nitrogen metabolism; Metabolic pathways; Carbon metabolism; Necroptosis; Proximal tubule bicarbonate reclamation","Transcriptional activation of mitochondrial biogenesis; Glutamate and glutamine metabolism","VEGFA-VEGFR2 signaling pathway; Amino acid metabolism; Metabolic reprogramming in colon cancer; 22q11.2 copy number variation syndrome; Amino acid metabolism pathway excerpt: histidine catabolism extension",17677.4,17041.2,17644.7,15392.9,15169.1,18358.2,1.07038196900258,0.09812571854188039,0.33512458859342603,0.47479370615852934,0.5498149535419419,0.25978345264744995,4455]
["P00374","dihydrofolate reductase [OS=Homo sapiens]",41,7,22,7,187,21.4,7.42,58.4,"cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;mitochondrion","nucleic acid binding activity;other molecular function","DHFR","ENSG00000228716","One carbon pool by folate; Folate biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Antifolate resistance","G1/S-Specific Transcription; Metabolism of folate and pterines; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation","Fluoropyrimidine activity; Folate metabolism; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration and one-carbon metabolism; Ethanol effects on histone modifications; Nucleotide metabolism",2443,2423.8,2297.2,2935.6,2891.6,1746.5,0.9459049077729511,-0.08023293878569214,0.7450643476246454,0.12780621770607045,0.8273587536901448,0.08230613378045225,6582]
["P00387","NADH-cytochrome b5 reductase 3 [OS=Homo sapiens]",45,12,80,12,301,34.2,7.59,261.81,"other metabolic processes;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CYB5R3","ENSG00000100243","Amino sugar and nucleotide sugar metabolism","Neutrophil degranulation; Phase I - Functionalization of compounds; Vitamin C (ascorbate) metabolism","Oxidation by cytochrome P450",7927.3,8517.4,8211.6,7180,7109.5,8334.2,1.0898438363309275,0.12412142611088721,0.19189137652726354,0.7169445417354758,0.4327473221344552,0.3637656108837128,3241]
["P00390","Glutathione reductase, mitochondrial [OS=Homo sapiens]",47,18,83,18,522,56.2,8.5,280.8,"other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion","other molecular function","GSR","ENSG00000104687","Glutathione metabolism; Metabolic pathways; Thyroid hormone synthesis; Diabetic cardiomyopathy","","Glutathione metabolism; Selenium micronutrient network; Nuclear receptors meta-pathway; NRF2 pathway; Amino acid metabolism; One-carbon metabolism and related pathways; Oxidative stress response; Vitamin D-sensitive calcium signaling in depression; Sulfation biotransformation reaction; Metapathway biotransformation Phase I and II",9382.7,9421.4,9606.5,9536.3,8739.1,9030.8,1.040445027136694,0.05720074097673462,0.20420525103553425,0.6899330944409027,0.44500184252197966,0.3516381908269966,3354]
["P00395","Cytochrome c oxidase subunit 1 [OS=Homo sapiens]",2,1,2,1,513,57,6.7,6.58,"other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MT-CO1","ENSG00000198804","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Electron transport chain: OXPHOS system in mitochondria; Effects of nitric oxide; Nonalcoholic fatty liver disease; Neuroinflammation; Mitochondrial complex IV assembly",302.7,374.5,327.5,362,315,707.4,0.7257295579312337,-0.4624960647375758,0.3702392348027269,0.4315175603117949,0.5687428682583293,0.24508403612906937,4758]
["P00403","Cytochrome c oxidase subunit 2 [OS=Homo sapiens]",31,6,33,6,227,25.5,4.82,81.38,"other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MT-CO2","ENSG00000198712","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Cytoprotection by HMOX1; Respiratory electron transport; TP53 Regulates Metabolic Genes","Electron transport chain: OXPHOS system in mitochondria; Endothelin pathways; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Neuroinflammation; Mitochondrial complex IV assembly; CCL18 signaling pathway",4918.8,5139.9,5024.3,4048.8,4186.1,5395.3,1.1065868439201185,0.14611667696491948,0.3255628485997055,0.4873651601977795,0.5452655500493234,0.26339194023011087,4364]
["P00439","phenylalanine-4-hydroxylase [OS=Homo sapiens]",2,1,1,1,452,51.8,6.6,0,"other metabolic processes","cytosol","other molecular function","PAH","ENSG00000171759","Phenylalanine metabolism; Phenylalanine, tyrosine and tryptophan biosynthesis; Folate biosynthesis; Metabolic pathways; Biosynthesis of amino acids","Phenylketonuria; Phenylalanine metabolism","Biogenic amine synthesis; Sudden infant death syndrome (SIDS) susceptibility pathways",39.2,64.7,72.2,53,42.1,26.4,1.449382716049383,0.5354385953380655,0.2228249801982612,0.652036123398987,0.4642610548087489,0.3332377462090169,3508]
["P00441","Superoxide dismutase [Cu-Zn] [OS=Homo sapiens]",97,16,152,16,154,15.9,6.13,551.15,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","SOD1","ENSG00000142168","Peroxisome; Longevity regulating pathway; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Platelet degranulation ; Detoxification of Reactive Oxygen Species","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; AGE/RAGE pathway; Dopamine metabolism; Amyotrophic lateral sclerosis (ALS); Copper homeostasis; Physico-chemical features and toxicity-associated pathways; One-carbon metabolism and related pathways; Oxidative stress response; Extracellular vesicles in the crosstalk of cardiac cells",18375.7,18716,17990.2,18055.1,17869.9,29445.5,0.8426109636609784,-0.24706140718987726,0.4215863794230203,0.3751134287181326,0.5991395775234019,0.22247199115524965,5143]
["P00450","Ceruloplasmin [OS=Homo sapiens]",1,1,1,1,1065,122.1,5.72,2.11,"transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi","other molecular function","CP","ENSG00000047457","Porphyrin and chlorophyll metabolism; Ferroptosis","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Metal ion SLC transporters; Iron uptake and transport; Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages); Defective CP causes aceruloplasminemia (ACERULOP)","Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway",67.5,53.8,65.5,39.3,43,64.3,{"$f":"AVERAGE(S898:U898)/AVERAGE(V898:X898)","v":1.2742155525238745},{"$f":"LOG(Y898,2)","v":0.3496093515758501},{"$f":"TTEST(V898:X898,S898:U898,2,2)","v":0.2060021025051777},0.686128347098142,{"$f":"AA898*7309/AE898","v":0.44691877922539147},0.34977139619528924,3369]
["P00488","Coagulation factor XIII A chain [OS=Homo sapiens]",1,1,2,1,732,83.2,6.09,2.76,"protein metabolism;other metabolic processes;stress response","non-structural extracellular;other cell component","other molecular function","F13A1","ENSG00000124491","Complement and coagulation cascades; Coronavirus disease","Platelet degranulation ; Interleukin-4 and Interleukin-13 signaling; Common Pathway of Fibrin Clot Formation","Complement system",69.7,76.5,150.1,66.3,70.2,52.8,1.5652403592181718,0.6463842152575768,0.24619136636924444,{"$f":"-LOG10(AA899)","v":0.6087271813151047},0.48306381121954567,{"$f":"-LOG10(AC899)","v":0.3159954965154434},3725]
["P00491","purine nucleoside phosphorylase [OS=Homo sapiens]",66,15,60,15,289,32.1,6.95,220.04,"other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","PNP","ENSG00000198805","Purine metabolism; Pyrimidine metabolism; Nicotinate and nicotinamide metabolism; Metabolic pathways","Neutrophil degranulation; Purine catabolism; Purine salvage","VEGFA-VEGFR2 signaling pathway",6261.3,6382.8,6955.7,5834.4,5076.4,5116.8,1.2228780353889541,0.29028052282371064,0.021783654251885703,1.6618692646946158,0.15578936294230195,0.8074621986093368,1022]
["P00492","Hypoxanthine-guanine phosphoribosyltransferase [OS=Homo sapiens]",62,10,57,10,218,24.6,6.68,199.36,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","other molecular function","HPRT1","ENSG00000165704","Purine metabolism; Drug metabolism; Metabolic pathways","Purine salvage","Mesodermal commitment pathway; Nucleotide metabolism",6551.7,7126.9,6466.7,6218.4,6605.2,3693.7,1.2196484897652764,0.2864654140641484,0.2660032520864831,0.5751130537652464,0.5022520716869298,0.29907826320022846,3871]
["P00505","Aspartate aminotransferase, mitochondrial [OS=Homo sapiens]",51,22,164,22,430,47.5,9.01,475.51,"other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;other cell component","other molecular function","GOT2","ENSG00000125166","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Cysteine and methionine metabolism; Arginine and proline metabolism; Tyrosine metabolism; Phenylalanine metabolism; Phenylalanine, tyrosine and tryptophan biosynthesis; Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids; Fat digestion and absorption","Gluconeogenesis; Glyoxylate metabolism and glycine degradation; Aspartate and asparagine metabolism; Glutamate and glutamine metabolism; Degradation of cysteine and homocysteine","Alanine and aspartate metabolism; Amino acid metabolism; Metabolic reprogramming in colon cancer; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis and gluconeogenesis",24180.8,25007.6,25096.6,21795,20893.5,16135.4,1.2628370441266221,0.3366684864745816,0.044304800015634485,1.353549219434394,0.2201385338642233,0.6573039302779513,1471]
["P00519","Tyrosine-protein kinase ABL1 [OS=Homo sapiens]",1,1,1,1,1130,122.8,8.66,0,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;kinase activity;other molecular function","ABL1","ENSG00000097007","ErbB signaling pathway; Ras signaling pathway; Cell cycle; Axon guidance; Neurotrophin signaling pathway; Pathogenic Escherichia coli infection; Pathways in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chronic myeloid leukemia; Viral myocarditis","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Factors involved in megakaryocyte development and platelet production; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RHO GTPases Activate WASPs and WAVEs; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Myogenesis; Cyclin D associated events in G1; RUNX2 regulates osteoblast differentiation; HDR through Single Strand Annealing (SSA); Role of ABL in ROBO-SLIT signaling","miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; TP53 network; Cell cycle; Integrated breast cancer pathway; Microtubule cytoskeleton regulation; Pathogenic Escherichia coli infection; Retinoblastoma gene in cancer; ATM signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Imatinib and chronic myeloid leukemia; VEGFA-VEGFR2 signaling pathway; Ras signaling; Acute viral myocarditis; EGF/EGFR signaling pathway; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)",25.3,21.9,21.6,32.6,41,44.8,0.5810810810810813,-0.7831886109268514,0.012089728680345928,1.9175834455371432,0.11892843462267617,0.9247142974137457,743]
["P00558","phosphoglycerate kinase 1 [OS=Homo sapiens]",76,29,692,24,417,44.6,8.1,2197.3,"protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;other membranes;cytosol","kinase activity;other molecular function","PGK1","ENSG00000102144","Glycolysis / Gluconeogenesis; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; HIF-1 signaling pathway","Glycolysis; Gluconeogenesis; Manipulation of host energy metabolism","Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Glycolysis and gluconeogenesis",100921.6,102559.4,98670.1,96243.4,92534.9,93015.5,1.07224183072871,0.10063032430914218,0.013841423940090658,1.8588192294230954,0.1282217586541478,0.8920382707485427,789]
["P00568","Adenylate kinase isoenzyme 1 [OS=Homo sapiens]",39,6,16,6,194,21.6,8.63,37.83,"other metabolic processes","cytosol;cytoskeleton;other cell component","kinase activity;other molecular function","AK1","ENSG00000106992","Purine metabolism; Thiamine metabolism; Metabolic pathways; Biosynthesis of cofactors","Interconversion of nucleotide di- and triphosphates","",1234.6,1202,1204.3,1145.7,1171.7,983.2,1.1031024662182631,0.1415668078277097,0.13122377657401138,0.8819874675568323,0.3662140446656927,0.4362650040980915,2619]
["P00734","Prothrombin [OS=Homo sapiens]",6,3,3,3,622,70,5.9,10.7,"protein metabolism;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi","signal transduction activity or receptor binding;other molecular function","F2","ENSG00000180210","Phospholipase D signaling pathway; Neuroactive ligand-receptor interaction; Complement and coagulation cascades; Platelet activation; Regulation of actin cytoskeleton; Pathogenic Escherichia coli infection; Coronavirus disease; Pathways in cancer","Cell surface interactions at the vascular wall; Regulation of Complement cascade; G alpha (q) signalling events; Peptide ligand-binding receptors; Thrombin signalling through proteinase activated receptors (PARs); Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Intrinsic Pathway of Fibrin Clot Formation; Common Pathway of Fibrin Clot Formation; Defective F8 cleavage by thrombin; Gamma-carboxylation of protein precursors; Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus; Removal of aminoterminal propeptides from gamma-carboxylated proteins; Platelet Aggregation (Plug Formation); Defective factor XII causes hereditary angioedema","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Blood clotting cascade; IL1 and megakaryocytes in obesity; Regulation of actin cytoskeleton; Complement and coagulation cascades",220.5,224.2,245,230,200.1,159.6,1.1695777513990164,0.22598777261742056,0.20061585078461935,0.6976347560796291,0.44152401487045556,0.3550456697940414,3321]
["P00747","Plasminogen [OS=Homo sapiens]",4,3,9,3,810,90.5,7.24,19.13,"cell organization and biogenesis;protein metabolism;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","PLG","ENSG00000122194","Neuroactive ligand-receptor interaction; Complement and coagulation cascades; Staphylococcus aureus infection; Influenza A","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Signaling by PDGF; Platelet degranulation ; Activation of Matrix Metalloproteinases; Dissolution of Fibrin Clot","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Blood clotting cascade; Complement system; Fibrin complement receptor 3 signaling pathway; Complement and coagulation cascades",1435.6,1432.7,1358.9,1165.8,1215.3,1320,1.1421469292912918,0.19174825536346993,0.027851160507480738,1.55515670384772,0.17747526778480968,0.7508621598650149,1147]
["P00813","adenosine deaminase [OS=Homo sapiens]",69,19,119,19,363,40.7,5.95,352.3,"cell adhesion;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","ADA","ENSG00000196839","Purine metabolism; Metabolic pathways; Primary immunodeficiency","Purine salvage","",10391.3,10497.8,10770.6,10040.6,9749.2,8942.4,1.1018891696424218,0.13997912186891784,0.04834103494457877,1.3156840559162006,0.2304792070514848,0.6373682488866029,1533]
["P00846","ATP synthase subunit A [OS=Homo sapiens]",4,1,5,1,226,24.8,10.1,16.69,"other metabolic processes;stress response;transport;other biological processes","other membranes;mitochondrion","transporter activity","MT-ATP6","ENSG00000198899","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation",817.1,1059.1,827.8,723.5,859.9,969,1.0593950791412003,0.08324071248771807,0.6589739347359509,0.18113176328796338,0.7668270162370745,0.11530259480806353,6281]
["P00918","Carbonic anhydrase 2 [OS=Homo sapiens]",26,5,6,5,260,29.2,7.4,18.9,"other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","CA2","ENSG00000104267","Nitrogen metabolism; Metabolic pathways; Proximal tubule bicarbonate reclamation; Collecting duct acid secretion; Gastric acid secretion; Pancreatic secretion; Bile secretion","Reversible hydration of carbon dioxide; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide","Proximal tubule transport",296.8,279.6,304.2,295.9,269.3,1146.1,0.5145795593992872,-0.9585339447316596,0.39080989657621285,0.40803444706683034,0.5815206706179845,0.2354348433159686,4912]
["P00966","Argininosuccinate synthase [OS=Homo sapiens]",5,3,3,3,412,46.5,8.02,6.49,"other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","ASS1","ENSG00000130707","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Metabolic pathways; Biosynthesis of amino acids; Fluid shear stress and atherosclerosis","Urea cycle","Alanine and aspartate metabolism; Amino acid metabolism",399.5,432.1,438.3,416.4,386.2,712.9,0.8379412735070934,-0.25507895763211486,0.4788373349793132,0.31981199497539453,0.6398212214559049,0.19394135942485236,5470]
["P00973-1","2'-5'-oligoadenylate synthase 1 [OS=Homo sapiens]",18,6,13,6,400,46,8.22,35.48,"cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component","nucleic acid binding activity;other molecular function","OAS1","ENSG00000089127","NOD-like receptor signaling pathway; Hepatitis C; Measles; Influenza A; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease","OAS antiviral response; Interferon gamma signaling; Interferon alpha/beta signaling","Immune response to tuberculosis; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; Type II interferon signaling (IFNG)",842.8,830.6,931.1,941.5,876.9,728.7,1.022535432452593,0.03215083567359534,0.7995199278978848,0.09717070706692785,0.8639401468074572,0.063516344108659,6764]
["P01008","Antithrombin-III [OS=Homo sapiens]",2,1,2,1,464,52.6,6.71,2.3,"stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi","enzyme regulator activity;other molecular function","SERPINC1","ENSG00000117601","Complement and coagulation cascades","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Intrinsic Pathway of Fibrin Clot Formation; Common Pathway of Fibrin Clot Formation","Complement and coagulation cascades",280,251.9,280,228.8,251,486.2,0.8404761904761905,-0.25072114439494236,0.5689714484365762,0.24490952639501035,0.7014019761549899,0.15403301485600115,5929]
["P01023","alpha-2-macroglobulin [OS=Homo sapiens]",1,2,4,2,1474,163.2,6.46,8.32,"other biological processes","non-structural extracellular;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","A2M","ENSG00000175899","Complement and coagulation cascades","Platelet degranulation ; Intrinsic Pathway of Fibrin Clot Formation; Degradation of the extracellular matrix; HDL assembly","Complement system; Complement and coagulation cascades",795.7,733.5,1981.6,855.8,697,913.6,1.4234511839117743,0.5093930178880476,0.44487628879415714,0.3517607408473165,0.6135095839238669,0.21217864856413263,5300]
["P01024","Complement C3 [OS=Homo sapiens]",1,1,1,1,1663,187,6.4,3.6,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity","C3","ENSG00000125730","Neuroactive ligand-receptor interaction; Phagosome; Complement and coagulation cascades; Neutrophil extracellular trap formation; Alcoholic liver disease; Shigellosis; Pertussis; Legionellosis; Leishmaniasis; Chagas disease; Staphylococcus aureus infection; Tuberculosis; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Coronavirus disease; Viral carcinogenesis; Systemic lupus erythematosus","Purinergic signaling in leishmaniasis infection; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; G alpha (i) signalling events; Neutrophil degranulation; Peptide ligand-binding receptors; Alternative complement activation; Activation of C3 and C5","Allograft Rejection; Complement system; TYROBP causal network in microglia; Cells and molecules involved in local acute inflammatory response ; 16p11.2 distal deletion syndrome; Complement system in neuronal development and plasticity; Acquired partial lipodystrophy / Barraquer-Simons syndrome; Complement activation; Complement and coagulation cascades",89.7,88.5,104.6,75.1,71,60.7,1.3675048355899417,0.451545934494464,0.019609865314779432,1.7075253891598017,0.14945621020409058,0.8254860344464924,959]
["P01111","GTPase NRas [OS=Homo sapiens]",61,8,33,4,189,21.2,5.17,92.25,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi","other molecular function","NRAS","ENSG00000213281","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; Chemokine signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Mitophagy; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Apelin signaling pathway; Gap junction; Signaling pathways regulating pluripotency of stem cells; C-type lectin receptor signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Thermogenesis; Long-term potentiation; Neurotrophin signaling pathway; Cholinergic synapse; Serotonergic synapse; Long-term depression; Regulation of actin cytoskeleton; Insulin signaling pathway; GnRH signaling pathway; Estrogen signaling pathway; Melanogenesis; Prolactin signaling pathway; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Relaxin signaling pathway; GnRH secretion; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Alzheimer disease; Pathways of neurodegeneration; Alcoholism; Hepatitis C; Hepatitis B; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Endometrial cancer; Glioma; Prostate cancer; Thyroid cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis","Neutrophil degranulation; Tie2 Signaling; FCERI mediated MAPK activation; Regulation of RAS by GAPs; Signaling by BRAF and RAF1 fusions; Signaling by SCF-KIT; Downstream signal transduction; DAP12 signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; GRB2 events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; GRB2 events in EGFR signaling; SHC1 events in EGFR signaling; NCAM signaling for neurite out-growth; Signaling by FGFR1 in disease; p38MAPK events; SHC-mediated cascade:FGFR1; FRS-mediated FGFR1 signaling; SHC-mediated cascade:FGFR2; FRS-mediated FGFR2 signaling; Signaling by FGFR2 in disease; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ; SHC-mediated cascade:FGFR3; FRS-mediated FGFR3 signaling; FRS-mediated FGFR4 signaling; SHC-mediated cascade:FGFR4; Signaling by FGFR3 point mutants in cancer; FLT3 Signaling; Activated NTRK2 signals through FRS2 and FRS3; RAS processing; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; CD209 (DC-SIGN) signaling; Activation of RAS in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; SOS-mediated signalling; SHC-related events triggered by IGF1R; Signaling by FGFR4 in disease; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants; RAS signaling downstream of NF1 loss-of-function variants; Insulin receptor signalling cascade; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; MET activates RAS signaling; Signaling by FGFR3 fusions in cancer; Activated NTRK2 signals through RAS; Activated NTRK3 signals through RAS; Constitutive Signaling by Overexpressed ERBB2; RAS GTPase cycle mutants; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants","Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; RalA downstream regulated genes; TNF-alpha signaling pathway; Aryl hydrocarbon receptor Netpath; Bladder cancer; Extracellular vesicle-mediated signaling in recipient cells; RAC1/PAK1/p38/MMP2 pathway; G protein signaling pathways; BDNF-TrkB signaling; MAPK signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MAPK cascade; Ras signaling; Non-small cell lung cancer; Breast cancer pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Synaptic signaling pathways associated with autism spectrum disorder; Hippo-Merlin signaling dysregulation; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; EGFR tyrosine kinase inhibitor resistance; Kisspeptin/kisspeptin receptor system in the ovary; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; ErbB signaling pathway; DNA damage response (only ATM dependent); Serotonin receptor 2 and ELK-SRF/GATA4 signaling",1673,1728.9,1800.6,1441.5,1523.1,1400.7,1.1917852152200306,0.2531242552147597,0.005645331874687033,2.24831052192172,0.08369519406102946,1.077299479314977,493]
["P01116-2","Isoform 2B of GTPase KRas [OS=Homo sapiens]",61,8,40,4,188,21.4,8.12,99.1,"","","","KRAS","","","","",1412,1417.1,1437.2,1359.6,1405.8,1656.1,0.9648987900033926,-0.05155047148884588,0.6055208126060947,0.2178709249492675,0.7282790224350743,0.13770219941261092,6077]
["P01130","Low-density lipoprotein receptor [OS=Homo sapiens]",20,16,21,16,860,95.3,5.05,57.91,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","LDLR","ENSG00000130164","Endocytosis; Ovarian steroidogenesis; Aldosterone synthesis and secretion; Cortisol synthesis and secretion; Cushing syndrome; Bile secretion; Cholesterol metabolism; Toxoplasmosis; Hepatitis C; Lipid and atherosclerosis","Retinoid metabolism and transport; Cargo recognition for clathrin-mediated endocytosis; LDL clearance; Chylomicron clearance","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Oncostatin M signaling pathway; PCSK9-mediated LDL receptor degradation; Evolocumab mechanism to reduce LDL cholesterol; Lipid particles composition; Wnt signaling pathway and pluripotency; Statin inhibition of cholesterol production; Bile acids synthesis and enterohepatic circulation ; Metabolic pathway of LDL, HDL and TG, including diseases; Orexin receptor pathway; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5; DNA damage response (only ATM dependent)",2392.9,2483.1,2508.9,3481.6,4009.7,2908,0.7101343359649208,-0.49383613013181177,0.034867953010335025,1.4575735479612937,0.19336105352999902,0.7136309963353118,1318]
["P01591","Immunoglobulin J chain [OS=Homo sapiens]",38,3,20,3,159,18.1,5.24,60.44,"cell organization and biogenesis;stress response;other biological processes","non-structural extracellular","signal transduction activity or receptor binding;other molecular function","JCHAIN","ENSG00000132465","","Cell surface interactions at the vascular wall; Scavenging of heme from plasma","",1154.8,1117.5,1162.3,1289,1348.9,1275,0.8777632957652893,-0.1880961506461899,3.877111693400014E-3,2.4114916874816816,0.0715601246642947,1.1453289115232208,396]
["P01834","immunoglobulin kappa constant [OS=Homo sapiens]",19,1,1,1,107,11.8,6.52,5.11,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","IGKC","","","Initial triggering of complement; Classical antibody-mediated complement activation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; Scavenging of heme from plasma; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Regulation of Complement cascade; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers","",20,16.1,12.3,16.3,26.6,23.5,0.7289156626506025,-0.4561761940723301,0.18715000350212807,0.7278101604226297,0.4305569328287863,0.36596941336580413,3177]
["P01854","immunoglobulin heavy constant epsilon [OS=Homo sapiens]",4,1,1,1,428,47,8.06,2.5,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","IGHE","ENSG00000211891; ENSG00000276192","","FCERI mediated NF-kB activation; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; Interleukin-4 and Interleukin-13 signaling","",140.2,167.7,153.7,170.6,157.6,79.9,1.131095319774565,0.1777205133873819,0.5769773059040737,0.2388412684984457,0.7075716659149119,0.1502295663547091,5960]
["P01857","Immunoglobulin heavy constant gamma 1 [OS=Homo sapiens]",11,2,6,2,330,36.1,8.19,24.71,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","IGHG1","ENSG00000211896; ENSG00000277633","","Initial triggering of complement; Classical antibody-mediated complement activation; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Regulation of Complement cascade; Interleukin-4 and Interleukin-13 signaling","Interactions of natural killer cells in pancreatic cancer",385,364.1,378.4,438.1,478.4,278.6,0.9434356957576773,-0.08400390729276891,0.731859761568157,0.1355721301601763,0.8194183513023375,0.08649431402200809,6528]
["P01889","HLA class I histocompatibility antigen, B-7 alpha chain [OS=Homo sapiens]",43,13,95,3,362,40.4,5.85,312.16,"stress response;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","HLA-B","ENSG00000234745","Endocytosis; Phagosome; Cellular senescence; Cell adhesion molecules; Antigen processing and presentation; Natural killer cell mediated cytotoxicity; Type I diabetes mellitus; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Viral carcinogenesis; Autoimmune thyroid disease; Allograft rejection; Graft-versus-host disease; Viral myocarditis","DAP12 interactions; Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ER-Phagosome pathway; Interferon gamma signaling; Interferon alpha/beta signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Endosomal/Vacuolar pathway","Proteasome degradation; Allograft Rejection; Ebola virus pathway in host; Type II interferon signaling (IFNG)",3935.1,4121.7,3782.6,2784,3336.8,5387.5,1.0287705395236482,0.04092123450896816,0.8966821629793724,0.04736146924705605,0.929360455078876,0.031815810990367475,7052]
["P01903","HLA class II histocompatibility antigen, DR alpha chain [OS=Homo sapiens]",26,5,14,5,254,28.6,5,51.51,"other biological processes","plasma membrane;other membranes;other cytoplasmic organelle","","HLA-DRA","","","","",1283.1,1335.4,1313.1,1142.2,1217.1,1160.1,1.1171222367448996,0.15978705573806282,0.007218702685676839,2.1415408449616913,0.0959299962356582,1.0180455725719622,550]
["P01911","HLA class II histocompatibility antigen, DRB1-15 beta chain [OS=Homo sapiens]",23,6,13,2,266,29.9,7.74,31.26,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","HLA-DRB1","ENSG00000196126","Phagosome; Cell adhesion molecules; Antigen processing and presentation; Hematopoietic cell lineage; Th1 and Th2 cell differentiation; Th17 cell differentiation; Intestinal immune network for IgA production; Type I diabetes mellitus; Leishmaniasis; Toxoplasmosis; Staphylococcus aureus infection; Tuberculosis; Influenza A; Human T-cell leukemia virus 1 infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Asthma; Autoimmune thyroid disease; Inflammatory bowel disease; Systemic lupus erythematosus; Rheumatoid arthritis; Allograft rejection; Graft-versus-host disease; Viral myocarditis","Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling","Allograft Rejection; Vitamin D receptor pathway; Ebola virus pathway in host; Cancer immunotherapy by PD-1 blockade; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Genes associated with the development of rheumatoid arthritis; Network map of SARS-CoV-2 signaling pathway; Cytokines and inflammatory response",436.1,485.6,432.6,399.2,444.3,699.3,0.8778195488721806,-0.18800369579152743,0.54443893615774,0.26405082330379026,0.6832596470427407,0.16541422772479805,5824]
["P02042","Hemoglobin subunit delta [OS=Homo sapiens]",13,2,25,1,147,16,8.05,63.89,"other metabolic processes;transport;other biological processes","cytosol;other cell component","other molecular function","HBD","ENSG00000223609","","Factors involved in megakaryocyte development and platelet production","VEGFA-VEGFR2 signaling pathway",1071.1,952,948.5,710.8,844.7,685.9,1.3257785312750958,0.4068397961770766,0.018743134533294847,1.7271577775530083,0.14698880933889705,0.8327157280230167,932]
["P02533","Keratin, type I cytoskeletal 14 [OS=Homo sapiens]",42,19,57,6,472,51.5,5.16,160.3,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KRT14","ENSG00000186847","Estrogen signaling pathway; Staphylococcus aureus infection","Formation of the cornified envelope; Type I hemidesmosome assembly","Corticotropin-releasing hormone signaling pathway",2041.8,2098.5,3980,2558.6,3424,8519.1,0.5599550397539599,-0.8366171008027922,0.340026634898942,0.46848706255604633,0.5528931422639304,0.25735879674132095,4495]
["P02538","Keratin, type II cytoskeletal 6A [OS=Homo sapiens]",33,23,73,4,564,60,8,179.44,"cell organization and biogenesis;stress response;other biological processes","cytosol;cytoskeleton","cytoskeletal activity","KRT6A","ENSG00000205420","","Formation of the cornified envelope","Ectoderm differentiation; Ectoderm differentiation",1666.9,1620.5,4534.5,2384.4,3413.9,15991.8,0.35896576885833476,-1.4780818203458395,0.35728334214867175,0.446987231716835,0.5642575513752467,0.24852262011257403,4628]
["P02545","Prelamin-A/C [OS=Homo sapiens]",66,46,249,43,664,74.1,7.02,742.27,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","LMNA","ENSG00000160789","Apoptosis; Hypertrophic cardiomyopathy; Arrhythmogenic right ventricular cardiomyopathy; Dilated cardiomyopathy","Signaling by BRAF and RAF1 fusions; XBP1(S) activates chaperone genes","Arrhythmogenic right ventricular cardiomyopathy; Adipogenesis; Fas ligand pathway and stress induction of heat shock proteins; Lamin A-processing pathway; Nephrotic syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome",25664.1,25531.2,26009.5,26818.7,26635.8,27545.9,0.9531409721433476,-0.06923848644872889,0.015470670589948592,1.8104908610128294,0.13461325159754078,0.870912185190738,840]
["P02647","Apolipoprotein A-I [OS=Homo sapiens]",8,2,13,1,267,30.8,5.76,31.99,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;other molecular function","APOA1","ENSG00000118137","PPAR signaling pathway; Fat digestion and absorption; Vitamin digestion and absorption; Cholesterol metabolism; African trypanosomiasis; Lipid and atherosclerosis","PPARA activates gene expression; Platelet degranulation ; Scavenging of heme from plasma; Amyloid fiber formation; Scavenging by Class B Receptors; Heme signaling; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Retinoid metabolism and transport; HDL clearance; Defective ABCA1 causes TGD; HDL assembly; Scavenging by Class A Receptors; ABC transporters in lipid homeostasis; Chylomicron assembly; Chylomicron remodeling; HDL remodeling","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Complement system; PPAR-alpha pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Statin inhibition of cholesterol production; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5",444.9,380.9,404.1,335.9,388.3,191,1.3438592657342658,0.42638206128759093,0.16538264900643374,0.7815100560654252,0.4056314703315517,0.39186835825770744,2980]
["P02649","Apolipoprotein E [OS=Homo sapiens]",5,2,4,2,317,36.1,5.73,10.12,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;cytoskeletal activity;other molecular function","APOE","ENSG00000130203","Cholesterol metabolism; Alzheimer disease","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Amyloid fiber formation; Retinoid metabolism and transport; Nuclear signaling by ERBB4; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Chylomicron clearance; Scavenging by Class A Receptors; Chylomicron assembly; Chylomicron remodeling; HDL remodeling; Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors","Vitamin B12 metabolism; Alzheimer's disease and miRNA effects; Apoptosis-related network due to altered Notch3 in ovarian cancer; ApoE and miR-146 in inflammation and atherosclerosis; Statin inhibition of cholesterol production; Familial hyperlipidemia type 3; Alzheimer's disease",467.1,463.3,459.8,381.4,406.5,448.1,1.1247572815533982,0.1696137067942412,0.058351867540331614,1.2339452398845636,0.25281197383063647,0.597202360589716,1687]
["P02656","Apolipoprotein C-III [OS=Homo sapiens]",16,1,2,1,99,10.8,5.41,10.27,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","non-structural extracellular;other cytoplasmic organelle","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","APOC3","ENSG00000110245","PPAR signaling pathway; Cholesterol metabolism","Retinoid metabolism and transport; Chylomicron assembly; Chylomicron remodeling; HDL remodeling","PPAR-alpha pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Statin inhibition of cholesterol production",91.5,89.4,85.9,70.3,76.5,148.2,0.904406779661017,-0.14495628795198084,0.7265331642929995,0.13874455653359885,0.8153279437766825,0.0886676728237084,6513]
["P02671-1","Fibrinogen alpha chain [OS=Homo sapiens]",1,1,1,1,866,94.9,6.01,2.72,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGA","ENSG00000171560","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Coronavirus disease","ER-Phagosome pathway; Signaling by BRAF and RAF1 fusions; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Amyloid fiber formation; Integrin cell surface interactions; Platelet degranulation ; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Common Pathway of Fibrin Clot Formation; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway",125.7,103.3,499.5,152.1,110.1,101.3,2.0041265474552956,1.002973608144918,0.40049171982264664,0.39740645853731543,0.5867296011592953,0.2315620005925242,4989]
["P02675","Fibrinogen beta chain [OS=Homo sapiens]",7,4,12,4,491,55.9,8.27,24.85,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGB","ENSG00000171564","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Coronavirus disease","ER-Phagosome pathway; Platelet degranulation ; Common Pathway of Fibrin Clot Formation; Integrin cell surface interactions; Signaling by BRAF and RAF1 fusions; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway; Complement and coagulation cascades",1515.1,1317.4,7359.8,1798.2,1322.1,1446.4,2.2318742198962047,1.1582557245483005,0.3987688691708024,0.39927875325671364,0.5860851929960577,0.2320392506049656,4973]
["P02679","Fibrinogen gamma chain [OS=Homo sapiens]",2,1,2,1,453,51.5,5.62,5.09,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGG","ENSG00000171557","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Staphylococcus aureus infection; Coronavirus disease","ER-Phagosome pathway; Platelet degranulation ; Integrin cell surface interactions; Signaling by BRAF and RAF1 fusions; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Common Pathway of Fibrin Clot Formation; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway",129.7,115,930.6,196.3,118.6,109,2.772587874498703,1.4712331859395387,0.4074595957272357,0.38991545004716605,0.5911318350874089,0.22831565132528733,5038]
["P02686-1","myelin basic protein [OS=Homo sapiens]",3,1,1,1,304,33.1,9.79,2,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","MBP","ENSG00000197971; ENSGGOG00000009590","","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Neural crest differentiation; Glial cell differentiation; Spinal cord injury; Interleukin-1 (IL-1) structural pathway; MECP2 and associated Rett syndrome; MAPK cascade; Complement system in neuronal development and plasticity",27.5,23.4,25,36.9,28.5,66.2,0.5767477203647415,-0.7939876983197754,0.18139162275707568,0.7413827739153167,0.4249331316447007,0.3716794060497865,3120]
["P02749","Beta-2-glycoprotein 1 [OS=Homo sapiens]",4,2,5,2,345,38.3,7.97,7.37,"protein metabolism;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;other cell component","enzyme regulator activity;other molecular function","APOH","ENSG00000091583","Cholesterol metabolism","Platelet degranulation","",646.9,685.8,722.8,494.6,717.9,548.3,1.1673671058609723,0.2232583215597425,0.23743284864953013,0.6244591969217002,0.47506068731985096,0.3232509072496439,3653]
["P02751","fibronectin [OS=Homo sapiens]",12,20,36,20,2386,262.5,5.71,113.49,"","","","","","","","",2386.1,2176.4,7171.3,2711.6,2191.2,2600,1.5639228021538627,0.6451693005618113,0.43798884301080526,0.3585369522368951,0.6090678184105738,0.21533434690464645,5256]
["P02753","Retinol-binding protein 4 [OS=Homo sapiens]",4,1,1,1,201,23,6.07,1.83,"other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;other cell component","transporter activity;other molecular function","RBP4","ENSG00000138207","","Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision); Retinoid cycle disease events; Retinoid metabolism disease events","Sterol regulatory element-binding proteins (SREBP) signaling; Vitamin A and carotenoid metabolism",169,154.7,174.8,127,195.8,188,0.9759201252936569,-0.035165020417165696,0.8645993438192288,0.06318509840657273,0.9079535350538424,0.041936376133161896,6960]
["P02760","Protein AMBP [OS=Homo sapiens]",2,1,2,1,352,39,6.25,1.84,"cell adhesion;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","enzyme regulator activity;other molecular function","AMBP","ENSG00000106927","","Scavenging of heme from plasma","",421.8,396,406,404.6,452.5,286.5,1.0701294158796784,0.09778527920365937,0.6205153501647276,0.20724747055625903,0.7399815131920369,0.1307791300243961,6129]
["P02765","Alpha-2-HS-glycoprotein [OS=Homo sapiens]",5,3,23,3,367,39.3,5.72,66.88,"","","","","","","","",4451.2,4663.4,4137.9,3233.2,5121.5,1528.1,1.3409661229611038,0.42327279067015045,0.3445585557431024,0.4627369616370155,0.5551980784670052,0.2555520456378927,4536]
["P02766","Transthyretin [OS=Homo sapiens]",4,1,2,1,147,15.9,5.76,2.01,"other metabolic processes;transport;signal transduction","non-structural extracellular;other cytoplasmic organelle","signal transduction activity or receptor binding;other molecular function","TTR","ENSG00000118271","Thyroid hormone synthesis","Neutrophil degranulation; Amyloid fiber formation; Retinoid metabolism and transport; Non-integrin membrane-ECM interactions; The canonical retinoid cycle in rods (twilight vision); Retinoid cycle disease events","",132.1,117.6,113.1,147.9,165.1,106.3,0.8652516098259001,-0.20880837431786767,0.36324790669054957,0.4397968797563352,0.5648891382981334,0.24803677580807967,4700]
["P02768-1","Serum albumin [OS=Homo sapiens]",12,9,57,9,609,69.3,6.28,144.76,"stress response;other biological processes","non-structural extracellular;ER/Golgi;other cell component","nucleic acid binding activity;other molecular function","ALB","ENSG00000163631","Thyroid hormone synthesis","Cytoprotection by HMOX1; Scavenging of heme from plasma; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Recycling of bile acids and salts; Heme degradation; HDL remodeling; Heme biosynthesis","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Complement system; VEGFA-VEGFR2 signaling pathway",10508.8,9977.1,9692.1,9218.8,11913.2,8098.5,1.0324147722413233,0.046022689402743684,0.7983935753577368,0.0977829664575457,0.863488997083412,0.06374319201245025,6758]
["P02771","Alpha-fetoprotein [OS=Homo sapiens]",3,2,5,2,609,68.6,5.68,14.64,"other metabolic processes;developmental processes;signal transduction","non-structural extracellular;ER/Golgi;other cell component","other molecular function","AFP","ENSG00000081051","Hippo signaling pathway","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",1006.5,1042.4,1067.2,1049.3,1271.3,2405.2,0.6593804223623515,-0.6008170422437084,0.2707694096513636,0.5674004019146524,0.506022402235187,0.2958302559828101,3911]
["P02774","vitamin D-binding protein [OS=Homo sapiens]",8,2,7,2,474,52.9,5.54,29.89,"transport","non-structural extracellular","transporter activity;cytoskeletal activity;other molecular function","HEL-S-51","","","","",403.7,384.7,405.2,380,450.5,1837.1,0.44744339481181583,-1.1602229134929085,0.35887819161045875,0.44505293216831227,0.56445894178628,0.24836764276320772,4647]
["P02786","Transferrin receptor protein 1 [OS=Homo sapiens]",34,25,82,25,760,84.8,6.61,240.32,"protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","TFRC","ENSG00000072274","HIF-1 signaling pathway; Endocytosis; Phagosome; Ferroptosis; Hematopoietic cell lineage","RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; RHOC GTPase cycle; RND2 GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RND1 GTPase cycle; Transferrin endocytosis and recycling; RHOH GTPase cycle","Iron metabolism in placenta; Ferroptosis; 3q29 copy number variation syndrome",9681.2,9650.2,10405.2,9305.5,8895.7,9027,1.0921250762077552,0.127138091139984,0.03824339201884919,1.4174435946978068,0.20225828673355187,0.6940936758520135,1382]
["P02787","Serotransferrin [OS=Homo sapiens]",2,1,2,1,698,77,7.12,2.06,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","TF","ENSG00000091513","HIF-1 signaling pathway; Ferroptosis; Mineral absorption","Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cargo recognition for clathrin-mediated endocytosis; Transferrin endocytosis and recycling","Iron metabolism in placenta; Pluripotent stem cell differentiation pathway; Ferroptosis; IL-18 signaling pathway; 3q29 copy number variation syndrome; Sudden infant death syndrome (SIDS) susceptibility pathways",210.8,191,188,147,169.1,386.6,0.8393339974384516,-0.25268307616210395,0.649716053232821,0.1872764025215331,0.7593179777868067,0.11957631754447456,6254]
["P02788","Lactotransferrin [OS=Homo sapiens]",1,1,1,1,710,78.1,8.12,2.05,"protein metabolism;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","LTF","ENSG00000012223","","Neutrophil degranulation; Amyloid fiber formation; Mtb iron assimilation by chelation; Metal sequestration by antimicrobial proteins","Male infertility",204.9,186.1,188.4,164,183.7,136.2,1.1973548253771442,0.2598507453936047,0.10103394024101822,0.9955327095509818,0.3251682383186271,0.4878918818867441,2271]
["P02792","Ferritin light chain [OS=Homo sapiens]",62,11,90,11,175,20,5.78,266.59,"transport;other biological processes","non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component","other molecular function","FTL","ENSG00000087086","Ferroptosis; Necroptosis; Mineral absorption","Neutrophil degranulation; Scavenging by Class A Receptors; Golgi Associated Vesicle Biogenesis; Iron uptake and transport","Nuclear receptors meta-pathway; NRF2 pathway; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway",15717.7,14315.5,12322.2,10647.9,12880.8,14601.4,1.110812717511887,0.15161559954190523,0.4037760161727051,0.39385948121504777,0.5887091366858771,0.23009922394412852,5013]
["P02794","Ferritin heavy chain [OS=Homo sapiens]",43,5,13,5,183,21.2,5.55,47.17,"transport;other biological processes","non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component","other molecular function","FTH1","ENSG00000167996","Ferroptosis; Necroptosis; Mineral absorption","Neutrophil degranulation; Scavenging by Class A Receptors; Golgi Associated Vesicle Biogenesis; Iron uptake and transport","Iron metabolism in placenta; Nuclear receptors meta-pathway; NRF2 pathway; Ferroptosis",769.5,751.5,723.6,780.4,734,2290,0.5900010514141519,-0.7612105694491015,0.3666987953335189,0.43569051676659837,0.5668784888097905,0.24651002275582437,4728]
["P03891","NADH-ubiquinone oxidoreductase chain 2 [OS=Homo sapiens]",5,2,8,2,347,38.9,9.83,14.21,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;other cell component","signal transduction activity or receptor binding;transporter activity;other molecular function","MT-ND2","ENSG00000198763","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",736.3,849.5,849.1,654.9,639.3,481.9,1.3709250605258714,0.45514971060466486,0.030384758507743664,1.5173442109925288,0.18399519464216937,0.735193519205905,1207]
["P03897","NADH-ubiquinone oxidoreductase chain 3 [OS=Homo sapiens]",13,1,4,1,115,13.2,4.44,10.89,"other metabolic processes;stress response;transport;other biological processes","other membranes;mitochondrion","transporter activity","MT-ND3","ENSG00000198840","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",129.1,137.7,133.8,124,134.2,832.5,0.3672870633538095,-1.4450200127682076,0.38215361391023933,0.41776202906905335,0.5757907161554194,0.23973534181114392,4851]
["P03905","NADH-ubiquinone oxidoreductase chain 4 [OS=Homo sapiens]",7,3,13,3,459,51.5,9.35,35.17,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MT-ND4","ENSG00000198886","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",1175.2,1327.1,1404.5,1037.2,961,785.8,1.4033045977011493,0.4888281906380902,0.020319014481904693,1.6920973601405813,0.15216360332811618,0.8176892159233001,976]
["P03923","NADH-ubiquinone oxidoreductase chain 6 [OS=Homo sapiens]",8,1,2,1,174,18.6,4.22,9.21,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","other membranes;mitochondrion","transporter activity","MT-ND6","ENSG00000198695","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",195.2,205.2,219.3,154,154.7,186.6,1.2511609125782357,0.3232673473371961,0.031873777245453434,1.4965664668164376,0.18742191302254158,0.7271796335741092,1243]
["P03928","ATP synthase protein 8 [OS=Homo sapiens]",13,1,2,1,68,8,9.91,5.52,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","MT-ATP8","ENSG00000228253","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome",1415.9,899,870.8,605.9,1450.1,69.7,1.4986592651832338,0.5836724097644098,0.4661266406571317,0.3314960750125939,0.6302108058755042,0.20051415449132762,5406]
["P04004","Vitronectin [OS=Homo sapiens]",9,2,18,2,478,54.3,5.8,74.16,"cell adhesion;transport;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;extracellular structural activity;other molecular function","VTN","ENSG00000109072","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Complement and coagulation cascades; Human papillomavirus infection; Proteoglycans in cancer","Regulation of Complement cascade; Integrin cell surface interactions; ECM proteoglycans; Syndecan interactions; Molecules associated with elastic fibres","Primary focal segmental glomerulosclerosis (FSGS); Complement system; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; Inflammatory response pathway; Complement system in neuronal development and plasticity; Senescence and autophagy in cancer",1358.3,1335.9,1309.6,1039.9,1138.2,1014.6,1.2540482976790803,0.3265929123188146,2.554854274387717E-3,2.5926338664232724,0.057992018296583306,1.2366317762351304,322]
["P04040","catalase [OS=Homo sapiens]",49,20,80,20,527,59.7,7.39,257.61,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CAT","ENSG00000121691","Tryptophan metabolism; Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism; FoxO signaling pathway; Peroxisome; Longevity regulating pathway; Longevity regulating pathway; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Chemical carcinogenesis","Neutrophil degranulation; Peroxisomal protein import; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Detoxification of Reactive Oxygen Species","Selenium micronutrient network; Folate metabolism; Amyotrophic lateral sclerosis (ALS); Oxidative stress response; Tryptophan metabolism; Male infertility; DNA damage response (only ATM dependent)",7327.1,7553.2,7340.6,6944.4,6996.2,5750.6,1.1284685544811897,0.1743662174432441,0.11096119097826104,0.9548288905026248,0.3380639203251813,0.47100117658648244,2399]
["P04049","RAF proto-oncogene serine/threonine-protein kinase [OS=Homo sapiens]",18,10,19,7,648,73,9.2,53.28,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","RAF1","ENSG00000132155","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Cellular senescence; Vascular smooth muscle contraction; Axon guidance; VEGF signaling pathway; Apelin signaling pathway; Focal adhesion; Gap junction; Signaling pathways regulating pluripotency of stem cells; Neutrophil extracellular trap formation; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Long-term potentiation; Neurotrophin signaling pathway; Serotonergic synapse; Long-term depression; Regulation of actin cytoskeleton; Insulin signaling pathway; GnRH signaling pathway; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Melanogenesis; Prolactin signaling pathway; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Relaxin signaling pathway; Parathyroid hormone synthesis, secretion and action; GnRH secretion; Growth hormone synthesis, secretion and action; Alzheimer disease; Pathways of neurodegeneration; Alcoholism; Salmonella infection; Tuberculosis; Hepatitis C; Hepatitis B; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer","Signaling by BRAF and RAF1 fusions; Stimuli-sensing channels; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; CD209 (DC-SIGN) signaling; Rap1 signalling; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GP1b-IX-V activation signalling; Negative feedback regulation of MAPK pathway","IL-5 signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Endothelin pathways; Pilocytic astrocytoma; Glioblastoma signaling pathways; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Retinoblastoma gene in cancer; Aryl hydrocarbon receptor Netpath; Common pathways underlying drug addiction; Cardiac hypertrophic response; Bladder cancer; IL-3 signaling pathway; Extracellular vesicle-mediated signaling in recipient cells; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; Pathways affected in adenoid cystic carcinoma; TGF-beta signaling pathway; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; ERK pathway in Huntington's disease; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway; Fragile X syndrome; 22q11.2 copy number variation syndrome; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; Netrin-UNC5B signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Regucalcin in proximal tubule epithelial kidney cells; Kisspeptin/kisspeptin receptor system in the ovary; CAMKK2 pathway; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Angiotensin II receptor type 1 pathway; Malignant pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; EPO receptor signaling; Senescence and autophagy in cancer; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling",1691.6,1707.4,1709.6,1874.2,1826.1,2988.4,0.763765754182427,-0.388797861204507,0.2376978265128977,0.6239747894025334,0.47546070442878197,0.3228853705350794,3654]
["P04053","DNA nucleotidylexotransferase [OS=Homo sapiens]",3,1,1,1,509,58.5,8.43,2.25,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DNTT","ENSG00000107447","Non-homologous end-joining; Hematopoietic cell lineage","","",2.6,15,14.6,7.4,8.3,10.3,1.2384615384615387,0.3085490650861628,0.6452117587609638,0.1902977263443504,0.7569587070279108,0.12092781111954709,6230]
["P04062","glucosylceramidase [OS=Homo sapiens]",21,10,25,10,536,59.7,7.61,73.39,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","signal transduction activity or receptor binding;other molecular function","GBA","ENSG00000177628","Other glycan degradation; Sphingolipid metabolism; Metabolic pathways; Lysosome","Glycosphingolipid metabolism; Association of TriC/CCT with target proteins during biosynthesis","Sphingolipid pathway",3169.9,3249.7,3417.4,2972.1,3108.7,4172.5,0.959398437576195,-0.05979800484025913,0.7376341197215246,0.1321590029304725,0.8226072293324113,0.08480747809285652,6554]
["P04066","tissue alpha-L-fucosidase [OS=Homo sapiens]",21,9,25,9,466,53.7,6.84,71.08,"other metabolic processes","non-structural extracellular;other cytoplasmic organelle;other cell component","other molecular function","FUCA1","ENSG00000179163","Other glycan degradation; Lysosome","Neutrophil degranulation; Reactions specific to the complex N-glycan synthesis pathway","p53 transcriptional gene network",3322.5,3372.6,3367.4,2821,2693.4,2298.4,1.2879505426991604,0.36507719502660285,0.009017651502082112,2.0449065525343517,0.1057945663382314,0.9755366373095484,623]
["P04075","fructose-bisphosphate aldolase A [OS=Homo sapiens]",77,29,534,21,364,39.4,8.09,1806.83,"cell organization and biogenesis;other metabolic processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ALDOA","ENSG00000149925","Glycolysis / Gluconeogenesis; Pentose phosphate pathway; Fructose and mannose metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; HIF-1 signaling pathway","Neutrophil degranulation; Glycolysis; Platelet degranulation ; Gluconeogenesis","VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; 16p11.2 proximal deletion syndrome; Glycolysis and gluconeogenesis; Sudden infant death syndrome (SIDS) susceptibility pathways",59025.3,62377.4,59063.1,59033.5,57098.5,60892.3,{"$f":"AVERAGE(S962:U962)/AVERAGE(V962:X962)","v":1.0194408338290282},{"$f":"LOG(Y962,2)","v":0.02777804684208069},{"$f":"TTEST(V962:X962,S962:U962,2,2)","v":0.5029534628410883},0.29847219738208747,{"$f":"AA962*7309/AE962","v":0.6564440821259848},0.18280226250431486,5600]
["P04080","Cystatin-B [OS=Homo sapiens]",52,4,24,4,98,11.1,7.56,83.31,"other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","CSTB","ENSG00000160213","","Neutrophil degranulation","",3455.7,3596.5,3407,3610.7,3643.5,3212.9,0.9992452541773749,-1.0892791716128874E-3,0.9867989925985403,{"$f":"-LOG10(AA963)","v":0.005771302543791569},0.990185864484175,{"$f":"-LOG10(AC963)","v":4.2832777827010405E-3},7284]
["P04114","apolipoprotein B-100 [OS=Homo sapiens]",1,2,2,2,4563,515.3,7.05,5.51,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;other molecular function","APOB","ENSG00000084674","Fat digestion and absorption; Vitamin digestion and absorption; Cholesterol metabolism; Lipid and atherosclerosis","Heme signaling; Cell surface interactions at the vascular wall; Scavenging by Class B Receptors; Regulation of TLR by endogenous ligand; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Retinoid metabolism and transport; Cargo recognition for clathrin-mediated endocytosis; LDL clearance; Chylomicron clearance; Scavenging by Class A Receptors; Chylomicron assembly; Chylomicron remodeling; VLDL assembly; VLDL clearance; Scavenging by Class F Receptors; Scavenging by Class H Receptors; Platelet sensitization by LDL; LDL remodeling","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Statin inhibition of cholesterol production; Male infertility; Familial hyperlipidemia type 2",229,260.1,295.9,201.1,184.1,460.9,0.9277863136745067,-0.10813553059178085,0.8349901079985348,0.07831866950693504,0.8878298951645753,0.05167023542416857,6874]
["P04150","Glucocorticoid receptor [OS=Homo sapiens]",27,15,26,15,777,85.6,6.38,70.1,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","NR3C1","ENSG00000113580","Neuroactive ligand-receptor interaction","Potential therapeutics for SARS; Regulation of RUNX2 expression and activity; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Circadian Clock; SUMOylation of intracellular receptors; PTK6 Expression","Nuclear receptors; Adipogenesis; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Endoderm differentiation; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Transcription factor regulation in adipogenesis; White fat cell differentiation; Vitamin D in inflammatory diseases; 16p11.2 proximal deletion syndrome; Sudden infant death syndrome (SIDS) susceptibility pathways; Serotonin receptor 4/6/7 and NR3C signaling",1757,1738.2,1759.3,1932.4,1955.2,1829.2,0.9191330814441645,-0.1216543301746888,0.01728183168555945,1.762410228942028,0.1424046311045705,0.8464758868897815,887]
["P04156-1","Major prion protein [OS=Homo sapiens]",20,5,16,5,253,27.6,9,32.24,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function","PRNP","ENSG00000171867","Ferroptosis; Prion disease; Pathways of neurodegeneration","NCAM1 interactions; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","Complement system; Copper homeostasis; Prion disease pathway; Ferroptosis",1433.5,1431.6,1429.2,1452.4,1590.8,1661.7,0.9127292822376671,-0.13174107814826377,0.08995658869612617,1.0459670220952184,0.306523406424236,0.5135363567319885,2145]
["P04179","Superoxide dismutase [Mn], mitochondrial [OS=Homo sapiens]",39,7,31,7,222,24.7,8.25,102.06,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","mitochondrion","other molecular function","SOD2","ENSPPAG00000038347","FoxO signaling pathway; Peroxisome; Longevity regulating pathway; Longevity regulating pathway; Huntington disease; Chemical carcinogenesis; Lipid and atherosclerosis","","",4237.4,4088.5,3955.6,3830.3,3969.7,4373,1.0089131684876367,0.012802015095579634,0.8521286405085484,0.06949483757392265,0.8993802503215856,0.04605665342643584,6925]
["P04181-1","Ornithine aminotransferase, mitochondrial [OS=Homo sapiens]",51,15,92,15,439,48.5,7.03,291.77,"other metabolic processes;other biological processes","mitochondrion;nucleus;other cell component","other molecular function","OAT","ENSG00000065154; ENSPPAG00000034558; ENSPTRG00000003028","Arginine and proline metabolism; Metabolic pathways","Glutamate and glutamine metabolism","Amino acid metabolism; 22q11.2 copy number variation syndrome",9219.8,8982.7,9838.5,8646.5,7964.1,6560.2,1.2101869594489618,0.2752299438916944,0.07112320105992065,1.1479887051962412,0.2738880276854373,0.562426951403542,1898]
["P04183","Thymidine kinase, cytosolic [OS=Homo sapiens]",43,9,38,9,234,25.5,8.51,104.68,"cell organization and biogenesis;DNA metabolism;other metabolic processes","cytosol","kinase activity;other molecular function","TK1","ENSG00000167900","Pyrimidine metabolism; Drug metabolism; Metabolic pathways","Pyrimidine salvage; G1/S-Specific Transcription","Fluoropyrimidine activity; Pyrimidine metabolism",2885.6,2921.7,3393.1,2661.7,2327.1,1782.2,1.3587948604342048,0.4423276664265221,0.05616574387322211,1.250528484836812,0.24774618103161158,0.6059930313721756,1657]
["P04233-2","Isoform 2 of HLA class II histocompatibility antigen gamma chain [OS=Homo sapiens]",48,10,116,10,232,26.4,9.14,330.43,"","","","CD74","","","","",15466.5,15140.8,14862.2,12989.7,15204.5,13950.3,1.0788952295080023,0.1095547728814384,0.17069723438229742,0.7677735152194035,0.41189372271383684,0.3852148266682864,3029]
["P04259","keratin, type II cytoskeletal 6B [OS=Homo sapiens]",31,21,79,2,564,60,8,188.7,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","cytoskeletal activity","KRT6B","ENSG00000185479","","Formation of the cornified envelope","",225.4,187.6,822,194.8,259.3,578.2,1.1963576479705509,0.25864874390126463,0.7898905619161628,0.10243307535292269,0.8582295402178138,0.06639654115175195,6727]
["P04264","Keratin, type II cytoskeletal 1 [OS=Homo sapiens]",52,37,272,31,644,66,8.12,762.82,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","bone, tooth or skin structural activity;other molecular function","KRT1","ENSG00000167768","","Neutrophil degranulation; Formation of the cornified envelope","Corticotropin-releasing hormone signaling pathway",26698,24823.2,27864.3,27217.1,41089.7,33969.5,0.7761866629903507,-0.365524450997432,0.13637423654257588,0.8652676676870081,0.3713708252197046,0.43019221729998963,2684]
["P04406-1","glyceraldehyde-3-phosphate dehydrogenase [OS=Homo sapiens]",79,22,1504,22,335,36,8.46,5838.71,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","GAPDH; HEL-S-162eP; LOC117800120","ENSAMEG00000025937; ENSG00000111640; ENSGGOG00000009553; ENSPPAG00000039909; ENSPTRG00000004577","Glycolysis / Gluconeogenesis; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; HIF-1 signaling pathway; Alzheimer disease; Pathogenic Escherichia coli infection; Salmonella infection; Diabetic cardiomyopathy","Glycolysis; Gluconeogenesis","Cori cycle; Alzheimer's disease and miRNA effects; HIF1A and PPARG regulation of glycolysis; VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; 7q11.23 copy number variation syndrome; Glycolysis in senescence; Alzheimer's disease; Glycolysis and gluconeogenesis; Sudden infant death syndrome (SIDS) susceptibility pathways",133532.1,139804,134105.1,125776.7,120659.5,111905.4,1.1370189785389135,0.1852563351584494,0.02230281322273079,1.6516403526446761,0.15734677784260556,0.8031421461699174,1036]
["P04424","argininosuccinate lyase [OS=Homo sapiens]",19,8,21,8,464,51.6,6.48,62.06,"other metabolic processes","cytosol;other cell component","other molecular function","ASL","ENSG00000126522","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Metabolic pathways; Biosynthesis of amino acids","Urea cycle","Alanine and aspartate metabolism",1916.3,1993.2,2006.1,1753.1,1764.7,2077.2,1.057301161751564,0.08038637263384163,0.385491557316542,0.413985129029339,0.578079153144564,0.2380126919940716,4874]
["P04632","Calpain small subunit 1 [OS=Homo sapiens]",77,12,90,12,268,28.3,5.2,324.41,"protein metabolism;other biological processes","plasma membrane;other membranes;cytosol","other molecular function","CAPNS1","ENSG00000126247","Shigellosis","Formation of the cornified envelope; Degradation of the extracellular matrix; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models","Integrin-mediated cell adhesion",8474.7,8463.2,8631.4,8200,8346.5,5359.8,1.1672121718409774,0.22306683305920222,0.27808445223081707,0.5558232919669092,0.5114542680812888,0.29119319285673256,3974]
["P04637","Cellular tumor antigen p53 [OS=Homo sapiens]",6,3,3,3,393,43.6,6.79,7.18,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function","TP53","ENSG00000141510","Endocrine resistance; Platinum drug resistance; MAPK signaling pathway; Sphingolipid signaling pathway; Cell cycle; p53 signaling pathway; Mitophagy; PI3K-Akt signaling pathway; Apoptosis; Longevity regulating pathway; Ferroptosis; Cellular senescence; Wnt signaling pathway; Neurotrophin signaling pathway; Thyroid hormone signaling pathway; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Shigellosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Pathways in cancer; Transcriptional misregulation in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Colorectal cancer; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Thyroid cancer; Basal cell carcinoma; Melanoma; Bladder cancer; Chronic myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","TP53 Regulates Transcription of DNA Repair Genes; Autodegradation of the E3 ubiquitin ligase COP1; Ub-specific processing proteases; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of PTEN gene transcription; Factors involved in megakaryocyte development and platelet production; Interleukin-4 and Interleukin-13 signaling; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; TP53 Regulates Transcription of Death Receptors and Ligands; Oxidative Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Association of TriC/CCT with target proteins during biosynthesis; Pre-NOTCH Transcription and Translation; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; TP53 Regulates Transcription of Caspase Activators and Caspases; Regulation of TP53 Activity through Methylation; G2/M DNA damage checkpoint; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Activation of PUMA and translocation to mitochondria; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; Regulation of TP53 Activity through Association with Co-factors; Ovarian tumor domain proteases; Pyroptosis; SUMOylation of transcription factors; Regulation of TP53 Expression; RUNX3 regulates CDKN1A transcription; Activation of NOXA and translocation to mitochondria; Formation of Senescence-Associated Heterochromatin Foci (SAHF); PI5P Regulates TP53 Acetylation; Transcriptional  activation of  cell cycle inhibitor p21 ; Loss of function of TP53 in cancer due to loss of tetramerization ability","AMP-activated protein kinase (AMPK) signaling; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Fluoropyrimidine activity; TP53 network; Folate metabolism; Apoptosis modulation and signaling; Cell cycle; Metastatic brain tumor; Glioblastoma signaling pathways; Gastric cancer network 2; Oncostatin M signaling pathway; Spinal cord injury; Retinoblastoma gene in cancer; Amyotrophic lateral sclerosis (ALS); ATM signaling pathway; Apoptosis; Mammary gland development pathway - Involution (Stage 4 of 4); Bladder cancer; Copper homeostasis; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced HIF-1 survival signaling; Hepatitis C and hepatocellular carcinoma; Pathways affected in adenoid cystic carcinoma; TGF-beta signaling pathway; lncRNA-mediated mechanisms of therapeutic resistance; MAPK signaling pathway; miRNA regulation of p53 pathway in prostate cancer; Wnt signaling pathway and pluripotency; Endometrial cancer; PI3K-Akt signaling pathway; Caloric restriction and aging; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer; Ferroptosis; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; MicroRNA network associated with chronic lymphocytic leukemia; G1 to S cell cycle control; 22q11.2 copy number variation syndrome; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Unfolded protein response; 16p11.2 proximal deletion syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis in senescence; TCA cycle in senescence; Malignant pleural mesothelioma; Senescence and autophagy in cancer; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)",422.5,392.8,431.3,230.8,246.5,335.4,1.533899347852836,0.6172038184877137,0.01389888755480934,1.857019958605016,0.12826637517437053,0.8918871783105365,792]
["P04792","Heat shock protein beta-1 [OS=Homo sapiens]",29,5,7,5,205,22.8,6.4,25.69,"stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","HSPB1","ENSG00000106211","MAPK signaling pathway; VEGF signaling pathway; Amoebiasis","AUF1 (hnRNP D0) binds and destabilizes mRNA; MAPK6/MAPK4 signaling; Extra-nuclear estrogen signaling; VEGFA-VEGFR2 Pathway","Apoptosis-related network due to altered Notch3 in ovarian cancer; Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; ATM signaling in development and disease ; VEGFA-VEGFR2 signaling pathway; p38 MAPK signaling pathway; Extracellular vesicles in the crosstalk of cardiac cells; Ferroptosis; IL-18 signaling pathway; Intracellular trafficking proteins involved in CMT neuropathy",800.5,810.5,881.9,783.3,757.3,814.9,1.0583315644236893,0.08179167982572227,0.20838550799665143,0.6811324869844588,0.44955421427022585,0.3472179267591552,3388]
["P04818","thymidylate synthase [OS=Homo sapiens]",15,5,6,5,313,35.7,7.01,3.92,"DNA metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","TYMS","ENSG00000176890","Pyrimidine metabolism; One carbon pool by folate; Metabolic pathways; Antifolate resistance","Interconversion of nucleotide di- and triphosphates; G1/S-Specific Transcription","Fluoropyrimidine activity; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration and one-carbon metabolism; One-carbon metabolism and related pathways; Ethanol effects on histone modifications; Pyrimidine metabolism",312.2,292.5,326.9,583.7,632.5,590.8,0.5155506364139458,-0.9558139615410957,8.837598622785579E-5,4.0536657266782035,0.016998423245773633,1.7695913614110408,38]
["P04839","Cytochrome b-245 heavy chain [OS=Homo sapiens]",4,2,4,2,570,65.3,8.63,5.85,"other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","CYBB","ENSG00000165168","HIF-1 signaling pathway; Phagosome; Ferroptosis; Necroptosis; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Leukocyte transendothelial migration; AGE-RAGE signaling pathway in diabetic complications; Alzheimer disease; Prion disease; Pathways of neurodegeneration; Leishmaniasis; Coronavirus disease; Diabetic cardiomyopathy; Lipid and atherosclerosis","Neutrophil degranulation; RAC2 GTPase cycle; RAC3 GTPase cycle; RAC1 GTPase cycle; Detoxification of Reactive Oxygen Species; VEGFA-VEGFR2 Pathway; ROS and RNS production in phagocytes; Cross-presentation of particulate exogenous antigens (phagosomes); RHO GTPases Activate NADPH Oxidases","Alzheimer's disease and miRNA effects; VEGFA-VEGFR2 signaling pathway; Microglia pathogen phagocytosis pathway; Oxidative stress response; Ferroptosis; Alzheimer's disease; Type II interferon signaling (IFNG)",573.7,626.6,593.1,525.6,510.7,422.4,1.2294508809213687,0.2980140974661518,0.035410392134844926,1.4508692638361744,0.19459741061171545,0.7108629429192874,1330]
["P04843","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [OS=Homo sapiens]",63,36,375,36,607,68.5,6.38,1108.82,"protein metabolism;other metabolic processes","other membranes;cytosol;ER/Golgi;other cell component","","RPN1","ENSG00000163902","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum","SRP-dependent cotranslational protein targeting to membrane; Asparagine N-linked glycosylation; Maturation of spike protein","Proteasome degradation",45279.5,46889.7,46598.8,41985.2,41427.5,36981.5,1.1526136641133875,0.20490902793611745,0.020981056006674475,1.6781726569274973,0.15412114407314947,0.8121377757892498,995]
["P04844-1","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [OS=Homo sapiens]",52,22,187,1,631,69.2,5.69,634.88,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus;other cytoplasmic organelle","translation activity","RPN2","ENSG00000118705","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum","SRP-dependent cotranslational protein targeting to membrane; Asparagine N-linked glycosylation; Maturation of spike protein","Proteasome degradation",495.6,534.7,571,395.3,382.7,127.3,1.7688059206892748,0.8227757593795985,0.06143911684676342,1.2115550356740372,0.25763540162535503,0.5889944609000575,1743]
["P04844-2","Isoform 2 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [OS=Homo sapiens]",49,22,161,1,615,67.7,6.06,563.89,"","","","RPN2","","","","",13005.7,13516.5,14611.4,11247,10539,9175.7,1.3285317020706224,0.4098326545309986,0.011689938422648283,1.9321877765006488,0.11720406026218971,0.9310573429346505,729]
["P04899-1","guanine nucleotide-binding protein G(i) subunit alpha-2 [OS=Homo sapiens]",60,16,67,9,355,40.4,5.54,231.53,"cell-cell signaling;cell cycle OR cell proliferation;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","GNAI2","ENSCANG00000029469; ENSCATG00000043630; ENSCSAG00000014329; ENSG00000114353; ENSMFAG00000032665; ENSMMUG00000056280; ENSMNEG00000033996; ENSNLEG00000006962; ENSPANG00000023235; ENSPTRG00000014951; ENSRBIG00000038900; ENSRROG00000029350; ENSTSYG00000005938","Rap1 signaling pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Adrenergic signaling in cardiomyocytes; Axon guidance; Apelin signaling pathway; Gap junction; Platelet activation; Leukocyte transendothelial migration; Circadian entrainment; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; GABAergic synapse; Dopaminergic synapse; Long-term depression; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Melanogenesis; Oxytocin signaling pathway; Regulation of lipolysis in adipocytes; Renin secretion; Relaxin signaling pathway; Parathyroid hormone synthesis, secretion and action; Cushing syndrome; Growth hormone synthesis, secretion and action; Gastric acid secretion; Parkinson disease; Cocaine addiction; Morphine addiction; Alcoholism; Pertussis; Chagas disease; Toxoplasmosis; Human cytomegalovirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Chemical carcinogenesis","G alpha (i) signalling events; G alpha (z) signalling events; Adenylate cyclase inhibitory pathway; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; ADORA2B mediated anti-inflammatory cytokines production; Adrenaline,noradrenaline inhibits insulin secretion","Thyroid stimulating hormone (TSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; S1P receptor signal transduction; Complement system; G protein signaling pathways; Chemokine signaling pathway; Hippo signaling regulation pathways; Purinergic signaling; Calcium regulation in cardiac cells; Calcium regulation in cardiac cells",8111.6,8870.2,8689.5,7375.3,6896.3,7728.2,1.1668878807989165,0.22266594786092878,0.021158546034881317,1.674514179298632,0.15403168622405133,0.8123899302236596,1004]
["P04920-1","Anion exchange protein 2 [OS=Homo sapiens]",26,23,59,23,1241,136.9,6.29,248.64,"transport;developmental processes;other biological processes","plasma membrane;other membranes","transporter activity;other molecular function","SLC4A2","ENSG00000164889","Salivary secretion; Gastric acid secretion; Pancreatic secretion; Bile secretion","Bicarbonate transporters","Proximal tubule transport",4157.9,3878.3,4132.6,3627.6,3698.9,4072.9,1.06749478042704,0.09422901572826252,0.1938602546295239,0.7125112211657992,0.4346394481862546,0.3618708593497653,3260]
["P04921-1","Glycophorin-C [OS=Homo sapiens]",27,2,4,2,128,13.8,4.84,19.82,"","plasma membrane;other membranes;cytoskeleton","","GYPC","ENSG00000136732","Malaria","Cell surface interactions at the vascular wall","",368.4,407.5,366.4,441.9,473,758.7,0.6825406309751434,-0.5510131640760122,0.15658567929316583,0.8052479593173308,0.39464990688060314,0.40378799533231396,2900]
["P05023","Sodium/potassium-transporting ATPase subunit alpha-1 [OS=Homo sapiens]",46,42,245,42,1023,112.8,5.49,823.18,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;cytoskeletal activity;other molecular function","ATP1A1","ENSG00000163399","cGMP-PKG signaling pathway; cAMP signaling pathway; Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Insulin secretion; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Aldosterone synthesis and secretion; Aldosterone-regulated sodium reabsorption; Endocrine and other factor-regulated calcium reabsorption; Proximal tubule bicarbonate reclamation; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Carbohydrate digestion and absorption; Protein digestion and absorption; Bile secretion; Mineral absorption","Ion homeostasis; Ion transport by P-type ATPases; Potential therapeutics for SARS","Pre-implantation embryo; Proximal tubule transport",26198.7,26957.6,26248.1,20977.8,21878.1,23742.2,1.1922922726023715,0.2537379342463484,0.007378632044540308,2.1320241463849743,0.09717193083521641,1.0124591676236774,555]
["P05026","Sodium/potassium-transporting ATPase subunit beta-1 [OS=Homo sapiens]",8,3,5,3,303,35,8.53,5.59,"cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","transporter activity;other molecular function","ATP1B1","ENSG00000143153","cGMP-PKG signaling pathway; cAMP signaling pathway; Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Insulin secretion; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Aldosterone synthesis and secretion; Aldosterone-regulated sodium reabsorption; Endocrine and other factor-regulated calcium reabsorption; Proximal tubule bicarbonate reclamation; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Carbohydrate digestion and absorption; Protein digestion and absorption; Bile secretion; Mineral absorption","Ion homeostasis; Ion transport by P-type ATPases; Potential therapeutics for SARS; Basigin interactions","Proximal tubule transport; Calcium regulation in cardiac cells",616.8,654.4,601.2,505,511.5,626.3,1.1397613830046263,0.18873181773289838,0.14568030129328247,0.8365991690124589,0.38177745505650823,0.4181897213945358,2789]
["P05062","fructose-bisphosphate aldolase B [OS=Homo sapiens]",6,3,32,1,364,39.4,7.87,72.4,"cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;cytoskeleton","cytoskeletal activity;other molecular function","ALDOB","ENSG00000136872","Glycolysis / Gluconeogenesis; Pentose phosphate pathway; Fructose and mannose metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; HIF-1 signaling pathway","Glycolysis; Gluconeogenesis; Fructose catabolism; Hereditary fructose intolerance","Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Glycolysis and gluconeogenesis; Polyol pathway",60,37,33.7,37,39.8,83.7,0.8143302180685358,-0.29631415621423235,0.595281991345731,0.2252772556600338,0.720588949113274,0.1423124024631397,6038]
["P05067-1","Amyloid-beta A4 protein [OS=Homo sapiens]",13,8,19,8,770,86.9,4.82,63.9,"cell adhesion;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function","APP","ENSG00000142192","Serotonergic synapse; Alzheimer disease; Pathways of neurodegeneration","Amyloid fiber formation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Platelet degranulation ; G alpha (q) signalling events; G alpha (i) signalling events; ECM proteoglycans; Lysosome Vesicle Biogenesis; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; TRAF6 mediated NF-kB activation; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Formyl peptide receptors bind formyl peptides and many other ligands; Advanced glycosylation endproduct receptor signaling","Alzheimer's disease and miRNA effects; Endoderm differentiation; Apoptosis-related network due to altered Notch3 in ovarian cancer; Copper homeostasis; TGF-beta signaling pathway; Fragile X syndrome; Inclusion body myositis; Alzheimer's disease",2000.3,2038.3,2048.6,2191.8,2379.7,2105.2,0.9117078796411401,-0.13335645043458094,0.07545969228636255,1.122284970121072,0.2826934346084182,0.548684277631617,1951]
["P05089","Arginase-1 [OS=Homo sapiens]",7,2,2,2,322,34.7,7.21,2.25,"other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","ARG1","ENSG00000118520","Arginine biosynthesis; Arginine and proline metabolism; Metabolic pathways; Biosynthesis of amino acids; Amoebiasis","Neutrophil degranulation; Urea cycle","Spinal cord injury; Amino acid metabolism; IL-18 signaling pathway",140.7,138.1,163.8,165.7,189,171.5,0.8411250475104523,-0.24960779736487773,0.060680034333705626,1.2169541821546763,0.25621627437611466,0.5913932881460972,1731]
["P05091","Aldehyde dehydrogenase, mitochondrial [OS=Homo sapiens]",4,2,2,1,517,56.3,7.05,6.5,"other metabolic processes","mitochondrion","other molecular function","ALDH2","ENSG00000111275","Glycolysis / Gluconeogenesis; Ascorbate and aldarate metabolism; Fatty acid degradation; Valine, leucine and isoleucine degradation; Lysine degradation; Arginine and proline metabolism; Histidine metabolism; Tryptophan metabolism; beta-Alanine metabolism; Glycerolipid metabolism; Pyruvate metabolism; Pantothenate and CoA biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Alcoholic liver disease","Ethanol oxidation; Metabolism of serotonin","Fatty acid omega-oxidation; Ethanol effects on histone modifications; Tryptophan metabolism; Fluoroacetic acid toxicity",62.8,64.9,68,84,84.5,61.8,0.849761181068172,-0.23487065516604164,0.2054428430787466,0.6873089834629365,0.4466334741411538,0.3500487306824157,3362]
["P05114","Non-histone chromosomal protein HMG-14 [OS=Homo sapiens]",51,6,23,6,100,10.7,9.6,67.88,"cell organization and biogenesis;DNA metabolism;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HMGN1","ENSG00000205581","","Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER","ATM signaling in development and disease ; p38 MAPK signaling pathway; Malignant pleural mesothelioma; Nucleotide excision repair in xeroderma pigmentosum",3163.4,3445.6,3457.5,2531,2860.3,1567.3,1.4466271951254563,0.5326931782341028,0.06055344368723997,1.2178611533989125,0.25582954908094624,0.5920492946437349,1730]
["P05141","ADP/ATP translocase 2 [OS=Homo sapiens]",52,18,249,5,298,32.8,9.69,692.48,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion","transporter activity;other molecular function","SLC25A5","ENSG00000005022","Calcium signaling pathway; cGMP-PKG signaling pathway; Necroptosis; Cellular senescence; Neutrophil extracellular trap formation; Alzheimer disease; Parkinson disease; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Influenza A; Human T-cell leukemia virus 1 infection; Chemical carcinogenesis; Diabetic cardiomyopathy","Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization","Electron transport chain: OXPHOS system in mitochondria; Alzheimer's disease and miRNA effects; Alzheimer's disease",38765.1,38614.3,38500.8,35261.3,33767.1,49370.8,0.9787245184089081,-0.03102525329457444,0.8740761429778233,0.058450733229757856,0.9144893399692113,0.03882135264741285,6986]
["P05161","Ubiquitin-like protein ISG15 [OS=Homo sapiens]",10,2,3,2,165,17.9,7.44,6.18,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;cytosol;translational apparatus;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ISG15","ENSG00000187608","RIG-I-like receptor signaling pathway; Human papillomavirus infection; Epstein-Barr virus infection; Coronavirus disease","Interferon alpha/beta signaling; ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling","Novel intracellular components of RIG-I-like receptor (RLR) pathway; Non-genomic actions of 1,25 dihydroxyvitamin D3; Cytosolic DNA-sensing pathway; p53 transcriptional gene network; Type II interferon signaling (IFNG)",344.4,303.2,358.1,298.1,264.3,156.3,1.3993321274523443,0.48473842266026473,0.1051554445562612,0.9781682362489292,0.3308571434617792,0.48035948416519175,2323]
["P05165-1","Propionyl-CoA carboxylase alpha chain, mitochondrial [OS=Homo sapiens]",28,16,30,16,728,80,7.52,89.32,"other metabolic processes","cytosol;mitochondrion","other molecular function","PCCA","ENSG00000175198","Valine, leucine and isoleucine degradation; Glyoxylate and dicarboxylate metabolism; Propanoate metabolism; Metabolic pathways; Carbon metabolism","Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency; Propionyl-CoA catabolism","",2484.8,2614.2,2617.7,2367.7,2313.9,2650.3,1.0524829853107651,0.07379691053043934,0.32019574363724485,0.4945844454558935,0.5409872145734218,0.26681299867499314,4326]
["P05166-1","propionyl-CoA carboxylase beta chain, mitochondrial [OS=Homo sapiens]",21,9,15,9,539,58.2,7.64,54.36,"other metabolic processes","cytosol;mitochondrion","other molecular function","PCCB","ENSG00000114054","Valine, leucine and isoleucine degradation; Glyoxylate and dicarboxylate metabolism; Propanoate metabolism; Metabolic pathways; Carbon metabolism","Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency; Propionyl-CoA catabolism","",1650.4,1630.9,1673,1562.6,1517.8,1395.8,1.106809347214155,0.14640673294428264,0.035998660260202486,1.443713661800161,0.1960612577062742,0.7076082157491611,1342]
["P05198","Eukaryotic translation initiation factor 2 subunit 1 [OS=Homo sapiens]",66,20,221,20,315,36.1,5.08,697.51,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;translational apparatus;nucleus;other cell component","translation activity;nucleic acid binding activity","EIF2S1","ENSG00000134001","Autophagy; Protein processing in endoplasmic reticulum; Apoptosis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Prion disease; Pathways of neurodegeneration; Hepatitis C; Measles; Influenza A; Herpes simplex virus 1 infection; Lipid and atherosclerosis","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency","Translation factors; Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; Ebola virus pathway in host; Nonalcoholic fatty liver disease; Unfolded protein response; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; Alzheimer's disease",19153.2,18780.2,19945.3,17837,17392,15061,1.1508987870351959,0.2027609647795536,0.05248032791252943,1.2800034600242185,0.24003674387526758,0.619722273118218,1598]
["P05204","Non-histone chromosomal protein HMG-17 [OS=Homo sapiens]",16,2,9,2,90,9.4,9.99,21.42,"cell organization and biogenesis;other biological processes","non-structural extracellular;nucleus;other cell component","nucleic acid binding activity;other molecular function","HMGN2","ENSG00000198830","","","",1436.1,1639.2,1817,1221.9,1158.2,975.8,1.457820554843708,0.5438131472576656,0.018051530592062045,1.743485968301004,0.14435299463608475,0.8405742021508625,914]
["P05362","Intercellular adhesion molecule 1 [OS=Homo sapiens]",24,9,19,9,532,57.8,7.99,72.98,"cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","ICAM1","ENSG00000090339","NF-kappa B signaling pathway; Cell adhesion molecules; Natural killer cell mediated cytotoxicity; TNF signaling pathway; Leukocyte transendothelial migration; AGE-RAGE signaling pathway in diabetic complications; African trypanosomiasis; Malaria; Staphylococcus aureus infection; Influenza A; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Rheumatoid arthritis; Viral myocarditis; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","Interleukin-4 and Interleukin-13 signaling; Interferon gamma signaling; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Integrin cell surface interactions; Interleukin-10 signaling","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; RANKL/RANK signaling pathway; Interleukin-11 signaling pathway; Spinal cord injury; Complement system; IL1 and megakaryocytes in obesity; Photodynamic therapy-induced NF-kB survival signaling; VEGFA-VEGFR2 signaling pathway; miRNAs involvement in the immune response in sepsis; Cells and molecules involved in local acute inflammatory response ; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; CAMKK2 pathway; p53 transcriptional gene network; Orexin receptor pathway; Type II interferon signaling (IFNG)",2255.2,2131.2,2153.8,2336.2,2363.9,1999.8,0.9761638233406468,-0.0348048084847444,0.6876646385832037,0.16262330758037752,0.7880434059900653,0.10344986060334489,6378]
["P05386","60S acidic ribosomal protein P1 [OS=Homo sapiens]",57,3,24,3,114,11.5,4.32,86.06,"protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus","enzyme regulator activity;other molecular function","RPLP1","ENSG00000137818","Ribosome; Coronavirus disease","L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",2721.9,2248.6,2251.9,3507.1,3955.9,3739.2,0.6447304993661959,-0.6332318622247831,0.0028714991558258,2.541891307058333,0.061367799210323905,1.212059451230495,342]
["P05455","Lupus La protein [OS=Homo sapiens]",70,34,273,34,408,46.8,7.12,717.54,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","nucleus;other cell component","nucleic acid binding activity","SSB","ENSG00000138385","Systemic lupus erythematosus","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination","",38723.5,36963.8,38106,38798.5,38169.2,27350.4,1.0908298751606862,0.12542611779334448,0.44719751026434224,0.34950062301400237,0.6149701980286129,0.21114592998934498,5315]
["P06213-1","insulin receptor [OS=Homo sapiens]",10,12,19,11,1382,156.2,6.2,54.6,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","INSR","ENSG00000171105","MAPK signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cGMP-PKG signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Phospholipase D signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Adherens junction; Insulin signaling pathway; Ovarian steroidogenesis; Regulation of lipolysis in adipocytes; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; Aldosterone-regulated sodium reabsorption; Alzheimer disease; Diabetic cardiomyopathy","PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Insulin receptor recycling; IRS activation; Signal attenuation","AMP-activated protein kinase (AMPK) signaling; Selenium micronutrient network; Vitamin B12 metabolism; Type II diabetes mellitus; Folate metabolism; Alzheimer's disease and miRNA effects; AGE/RAGE pathway; Nanoparticle triggered autophagic cell death; Transcription factor regulation in adipogenesis; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; PI3K-Akt signaling pathway; Ras signaling; NRF2-ARE regulation; Nonalcoholic fatty liver disease; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Male infertility; Insulin signaling; 16p11.2 distal deletion syndrome; Neuroinflammation and glutamatergic signaling; Malignant pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)",1766,1788.1,1837,1830.5,1811.1,1720.2,1.0054645827893618,0.007862264006204057,0.8188869111680664,0.08677607045795238,0.8770874023633349,0.056957126733446044,6824]
["P06396","Gelsolin [OS=Homo sapiens]",10,8,12,8,782,85.6,6.28,27.52,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","GSN","ENSG00000148180","Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Viral carcinogenesis","Neutrophil degranulation; Amyloid fiber formation; Sensory processing of sound by outer hair cells of the cochlea; Caspase-mediated cleavage of cytoskeletal proteins","Ebola virus pathway in host; Regulation of actin cytoskeleton; Senescence and autophagy in cancer",1780.3,1686,1709.5,1461.6,1570.1,1354.6,1.1799922485922079,0.23877738250719113,0.01830818257619565,1.7373547652725438,0.14560882094604355,0.8368123147746821,919]
["P06737-1","Glycogen phosphorylase, liver form [OS=Homo sapiens]",8,7,11,4,847,97.1,7.17,27.47,"other metabolic processes;other biological processes","non-structural extracellular;cytosol;other cell component","other molecular function","PYGL","ENSG00000100504; ENSPPAG00000035478; ENSPTRG00000006337","Starch and sucrose metabolism; Metabolic pathways; Necroptosis; Insulin signaling pathway; Glucagon signaling pathway; Insulin resistance","Neutrophil degranulation; Glycogen breakdown (glycogenolysis)","TNF-alpha signaling pathway; Glycogen synthesis and degradation; Glycogen metabolism",148.8,140.5,149.8,136.8,136.6,233.9,0.8655627833629017,-0.20828962600459786,0.5231974436846987,0.2813343866186927,0.6706506692198286,0.1735036377081609,5702]
["P06858","lipoprotein lipase [OS=Homo sapiens]",1,1,1,1,475,53.1,8.15,1.76,"cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","LPL","ENSG00000175445","Glycerolipid metabolism; PPAR signaling pathway; Cholesterol metabolism; Alzheimer disease","Transcriptional regulation of white adipocyte differentiation; Retinoid metabolism and transport; Assembly of active LPL and LIPC lipase complexes; Chylomicron remodeling","Fatty acid beta-oxidation; Sterol regulatory element-binding proteins (SREBP) signaling; Alzheimer's disease and miRNA effects; Adipogenesis; Aryl hydrocarbon receptor Netpath; Triacylglyceride synthesis; Lipid particles composition; Angiopoietin-like protein 8 regulatory pathway; PPAR signaling pathway; Statin inhibition of cholesterol production; Metabolic pathway of LDL, HDL and TG, including diseases; Overview of leukocyte-intrinsic Hippo pathway functions; Orexin receptor pathway; Familial partial lipodystrophy (FPLD); Familial  hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5; Alzheimer's disease; Vitamin A and carotenoid metabolism",68.5,67.2,62.5,78.7,91.2,91,0.7596780375622845,-0.3965399816309638,0.009834251458683448,2.007258691132044,0.10907214554099744,0.9622861438420809,659]
["P07099","epoxide hydrolase 1 [OS=Homo sapiens]",39,15,66,15,455,52.9,7.25,209.82,"other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","EPHX1","ENSG00000143819","Metabolism of xenobiotics by cytochrome P450; Bile secretion; Chemical carcinogenesis; Chemical carcinogenesis; Chemical carcinogenesis","Phase I - Functionalization of compounds","Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Benzene metabolism; Benzo(a)pyrene metabolism; Aflatoxin B1 metabolism; Metapathway biotransformation Phase I and II",7630.5,7904.8,7576.1,6094.4,6182.6,6299.1,1.2441470491653255,0.3151570116453346,2.1205060374451017E-4,3.673560486691487,0.02279232151130331,1.6422114375137502,68]
["P07311","Acylphosphatase-1 [OS=Homo sapiens]",26,3,5,3,99,11.3,9.31,14.66,"other metabolic processes","","other molecular function","ACYP1","ENSG00000119640","Pyruvate metabolism; Metabolic pathways","","",792.8,849.1,772.7,783.2,854.7,1004.2,0.9138942507853601,-0.12990085815324115,0.3334982798434011,0.4769064017967442,0.5488716341759555,0.26052921308644716,4441]
["P07384","Calpain-1 catalytic subunit [OS=Homo sapiens]",57,35,159,34,714,81.8,5.67,466.75,"protein metabolism;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","CAPN1","ENSG00000014216","Protein processing in endoplasmic reticulum; Apoptosis; Necroptosis; Cellular senescence; Alzheimer disease; Pathways of neurodegeneration; Shigellosis","Degradation of the extracellular matrix; Neutrophil degranulation; Formation of the cornified envelope; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models","Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Alzheimer's disease",16699,16429,17338.4,15734.6,15584.8,15426,1.079601415326428,0.11049877325037775,0.011990238442692223,1.9211721802609667,0.11842790915896954,0.9265459381079698,740]
["P07741-1","Adenine phosphoribosyltransferase [OS=Homo sapiens]",74,12,84,12,180,19.6,6.02,249.53,"other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","APRT","ENSG00000198931; ENSPPAG00000005769; ENSPTRG00000008466","Purine metabolism; Metabolic pathways","Neutrophil degranulation; Purine salvage","",10166.6,10367.1,9972.7,9085.2,8850.8,9965.6,1.093356653381885,0.1287640854876954,0.07231341497535623,1.1407811285790677,0.2765770539271998,0.5581838537501075,1911]
["P07992-1","DNA excision repair protein ERCC-1 [OS=Homo sapiens]",15,3,3,3,297,32.5,6.25,10.09,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ERCC1","ENSG00000012061; ENSPPAG00000043568; ENSPTRG00000011152","Platinum drug resistance; Nucleotide excision repair; Fanconi anemia pathway","HDR through Single Strand Annealing (SSA); Fanconi Anemia Pathway; Dual incision in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER","Male infertility; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum",265.3,234.7,260.5,246.1,246.8,166.7,1.1529714978775016,0.20535684917439212,0.299370651260718,0.5237907778749841,0.5287820420649076,0.2767233023207269,4138]
["P08069","Insulin-like growth factor 1 receptor [OS=Homo sapiens]",3,4,5,3,1367,154.7,5.8,12.45,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;transporter activity;kinase activity;other molecular function","IGF1R","ENSG00000140443","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; Ras signaling pathway; Rap1 signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Oocyte meiosis; Autophagy; Endocytosis; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Focal adhesion; Adherens junction; Signaling pathways regulating pluripotency of stem cells; Long-term depression; Ovarian steroidogenesis; Progesterone-mediated oocyte maturation; Pathways in cancer; Transcriptional misregulation in cancer; Proteoglycans in cancer; Glioma; Prostate cancer; Melanoma; Breast cancer; Hepatocellular carcinoma","Extra-nuclear estrogen signaling; IRS-related events triggered by IGF1R; Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R); SHC-related events triggered by IGF1R","MicroRNAs in cardiomyocyte hypertrophy; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Apoptosis; Focal adhesion; MECP2 and associated Rett syndrome; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Ebola virus pathway in host; Ras signaling; Breast cancer pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Head and neck squamous cell carcinoma; Endochondral ossification; EGFR tyrosine kinase inhibitor resistance; Endochondral ossification with skeletal dysplasias; Insulin signaling; Malignant pleural mesothelioma; Senescence and autophagy in cancer",279.8,282.1,255,268.1,282.5,241.7,1.0310488451344189,0.044112680876703225,0.6082201116462483,0.21593922340172078,0.729964005915013,0.13669855415062318,6090]
["P08237","ATP-dependent 6-phosphofructokinase, muscle type [OS=Homo sapiens]",48,27,99,24,780,85.1,7.99,319.74,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus","kinase activity;other molecular function","PFKM","ENSG00000152556","Glycolysis / Gluconeogenesis; Pentose phosphate pathway; Fructose and mannose metabolism; Galactose metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; RNA degradation; HIF-1 signaling pathway; AMPK signaling pathway; Thyroid hormone signaling pathway; Glucagon signaling pathway; Central carbon metabolism in cancer","Glycolysis","Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Insulin signaling; Glycolysis and gluconeogenesis",10525.6,10657.4,10605,10073.3,9877,9264.2,1.08808981841209,0.1217976514681419,0.025402107922960077,1.5951302431704018,0.1681739192109739,0.7742413546796088,1104]
["P08582-1","Melanotransferrin [OS=Homo sapiens]",10,5,7,5,738,80.2,5.94,23.52,"transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","MELTF","ENSG00000163975","","Post-translational modification: synthesis of GPI-anchored proteins; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","3q29 copy number variation syndrome",512.2,610.8,492.2,398.5,444.5,603.6,1.1165491497304023,0.15904675900779094,0.47948808965249423,0.31922217611050574,0.6404565875859065,0.19351030293859256,5472]
["P08670","Vimentin [OS=Homo sapiens]",82,44,1256,40,466,53.6,5.12,3152.9,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","VIM","ENSG00000026025","Epstein-Barr virus infection; MicroRNAs in cancer","Aggrephagy; Interleukin-4 and Interleukin-13 signaling; Chaperone Mediated Autophagy; Late endosomal microautophagy; Striated Muscle Contraction; RHOBTB1 GTPase cycle; Caspase-mediated cleavage of cytoskeletal proteins","Allograft Rejection; Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Mammary gland development pathway - Puberty (Stage 2 of 4); Apoptosis-related network due to altered Notch3 in ovarian cancer; Striated muscle contraction pathway; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Ciliary landscape; Burn wound healing; CCL18 signaling pathway; T-cell receptor (TCR) signaling pathway",119109.6,121752.9,116364,130907,135923,127700.4,0.9054473368845595,-0.14329736207740032,0.012091844024539332,1.9175074635219058,0.11878936555827684,0.9252224371838116,744]
["P08887-1","Interleukin-6 receptor subunit alpha [OS=Homo sapiens]",2,1,1,1,468,51.5,8.22,2.3,"other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","other molecular function","IL6R","ENSG00000160712","EGFR tyrosine kinase inhibitor resistance; Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor; HIF-1 signaling pathway; PI3K-Akt signaling pathway; JAK-STAT signaling pathway; Hematopoietic cell lineage; Th17 cell differentiation; Non-alcoholic fatty liver disease; Human cytomegalovirus infection; Coronavirus disease; Pathways in cancer","Transcriptional regulation of granulopoiesis; Potential therapeutics for SARS; Interleukin-4 and Interleukin-13 signaling; Interleukin-6 signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation","Pluripotent stem cell differentiation pathway; IL-6 signaling pathway; Hepatitis C and hepatocellular carcinoma; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Nonalcoholic fatty liver disease; Regulatory circuits of the STAT3 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Neuroinflammation and glutamatergic signaling; Senescence and autophagy in cancer; Sudden infant death syndrome (SIDS) susceptibility pathways",101.8,77.5,93.2,154.7,185.5,598.3,0.2903569525839105,-1.7841005151665859,0.19597681117971225,0.707795313196984,0.43643952252057183,0.36007592803008537,3282]
["P09001","39S ribosomal protein L3, mitochondrial [OS=Homo sapiens]",47,10,38,10,348,38.6,9.48,101.96,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL3","ENSG00000114686","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",3560.8,3709.6,3487.2,3648.6,3500.9,4087.2,0.9573629268379504,-0.06286215503253878,0.44306277623904256,{"$f":"-LOG10(AA1091)","v":0.35353473553158815},0.612858787193634,{"$f":"-LOG10(AC1091)","v":0.2126395825901048},5284]
["P09493-1","Tropomyosin alpha-1 chain [OS=Homo sapiens]",28,10,53,1,284,32.7,4.74,127.27,"cell organization and biogenesis;stress response;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","TPM1","ENSG00000140416; ENSGGOG00000009130; ENSPPAG00000004536; ENSPTRG00000007141","Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; MicroRNAs in cancer; Hypertrophic cardiomyopathy; Dilated cardiomyopathy","Smooth Muscle Contraction; Striated Muscle Contraction","Vitamin D receptor pathway; Striated muscle contraction pathway",71.2,72.9,63.3,76.2,86.4,75.3,0.8717948717948718,-0.1979393776119089,0.09298342267832548,1.0315944716724847,0.312754641673208,0.5047962361090362,2173]
["P09543-1","2',3'-cyclic-nucleotide 3'-phosphodiesterase [OS=Homo sapiens]",47,20,86,19,421,47.5,9.07,280.98,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;mitochondrion;other cell component","nucleic acid binding activity;other molecular function","CNP","ENSG00000173786; ENSPTRG00000009187","","","Glial cell differentiation; MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation",9568.7,9549.6,9886.6,7974.1,7824.9,8818.6,1.178218022877941,0.23660652679231134,0.011185534634751809,1.9513432531074952,0.11514798964140982,0.9387436399425977,710]
["P09651-1","Heterogeneous nuclear ribonucleoprotein A1 [OS=Homo sapiens]",68,24,322,1,372,38.7,9.13,982.14,"RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HNRNPA1; HNRPA1","ENSCANG00000041992; ENSCATG00000043560; ENSG00000135486; ENSMFAG00000031561; ENSMLEG00000044414; ENSMMUG00000012989; ENSMNEG00000042992; ENSPANG00000010434; ENSPPAG00000018027; ENSPTRG00000049417; ENSRBIG00000029387; ENSRROG00000030782","Spliceosome; Amyotrophic lateral sclerosis","mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA","mRNA processing; mRNA Processing",24432.9,24295,22092.1,27543.6,30740.5,37046.8,0.7428860946450733,-0.4287870729368159,0.04762704515606671,1.3221463618481037,0.22901715331953393,0.6401319879089034,1520]
["P09960-1","leukotriene A-4 hydrolase [OS=Homo sapiens]",49,28,124,28,611,69.2,6.18,365.67,"protein metabolism;other metabolic processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","LTA4H","ENSG00000111144; ENSPTRG00000005321","Arachidonic acid metabolism; Metabolic pathways","Neutrophil degranulation; Biosynthesis of protectins; Synthesis of Leukotrienes (LT) and Eoxins (EX); Biosynthesis of D-series resolvins; Biosynthesis of E-series 18(S)-resolvins; Biosynthesis of aspirin-triggered D-series resolvins; Biosynthesis of E-series 18(R)-resolvins","Eicosanoid synthesis; Eicosanoid metabolism via lipooxygenases (LOX); Prostaglandin and leukotriene metabolism in senescence",16792.5,16866.7,17363.3,15498.6,14364.9,10633.3,1.2599143636040377,0.33332567705659516,0.0768467101868314,1.1143747199441656,0.28540274631887735,0.5445418521555153,1968]
["P0CAP2-1","DNA-directed RNA polymerase II subunit GRINL1A [OS=Homo sapiens]",22,5,6,5,368,41.7,6.39,18.32,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction","nucleus;other cell component","other molecular function","POLR2M","ENSG00000255529","RNA polymerase","","",406.5,366.4,370.8,453.7,443.1,391.5,0.8877590623302026,-0.17175991239570765,0.10446912149676003,0.9810120573544406,0.32983361080769724,0.48170509082443963,2315]
["P0CG08","Golgi pH regulator B [OS=Homo sapiens]",11,3,12,3,455,52.9,9.28,50.47,"transport;developmental processes;other biological processes","other membranes;ER/Golgi","transporter activity","GPR89B","ENSG00000188092","","","",459.3,440.6,431.9,365.1,387.5,180.3,1.4275913817129382,0.513583097058879,0.114781999903502,0.9401262125957808,0.3434063189908703,0.4641917176852445,2443]
["P0DMV8","heat shock 70 kDa protein 1A [OS=Homo sapiens]",57,32,354,17,641,70,5.66,921,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","HSPA1A","ENSG00000204389; ENSG00000215328; ENSG00000234475; ENSG00000235941; ENSG00000237724","Spliceosome; MAPK signaling pathway; Protein processing in endoplasmic reticulum; Endocytosis; Longevity regulating pathway; Antigen processing and presentation; Estrogen signaling pathway; Prion disease; Legionellosis; Toxoplasmosis; Measles; Lipid and atherosclerosis","AUF1 (hnRNP D0) binds and destabilizes mRNA; Neutrophil degranulation; Regulation of HSF1-mediated heat shock response; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase; Viral RNP Complexes in the Host Cell Nucleus","Apoptosis modulation and signaling; Parkin-ubiquitin proteasomal system pathway; Nuclear receptors meta-pathway; NRF2 pathway; MAPK signaling pathway; Apoptosis modulation by HSP70; VEGFA-VEGFR2 signaling pathway",18302.5,18594.9,17933.2,17641.2,18213.1,12665.8,1.1300595011139714,0.17639873697859781,0.30085564406744286,0.5216418367089597,0.5292307827891553,0.27635490294511644,4155]
["P10114","Ras-related protein Rap-2a [OS=Homo sapiens]",50,8,41,4,183,20.6,4.82,124.75,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","RAP2A","ENSG00000125249","","","",624.6,618.2,645.1,533.1,554.3,508.7,1.1828206252741056,0.24223130558916586,0.00327019109161303,2.4854268688662295,0.06657890442506863,1.1766633555605757,359]
["P10412","Histone H1.4 [OS=Homo sapiens]",45,17,408,3,219,21.9,11.03,1195.29,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","H1-4","ENSG00000168298","","Formation of Senescence-Associated Heterochromatin Foci (SAHF); Apoptosis induced DNA fragmentation","Pathways affected in adenoid cystic carcinoma; Genotoxicity pathway",21357.8,20543,20135.6,19487.2,20849.3,63072.8,0.5999112265531242,-0.737179064977996,0.38979949727056545,0.4091587253332258,0.580963402436901,0.23585122495961144,4904]
["P10747-1","T-cell-specific surface glycoprotein CD28 [OS=Homo sapiens]",8,2,6,2,220,25.1,9.39,14.27,"developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","CD28","ENSG00000178562; ENSGGOG00000041735; ENSPPAG00000034998; ENSPTRG00000012833","Cell adhesion molecules; T cell receptor signaling pathway; Intestinal immune network for IgA production; Type I diabetes mellitus; Measles; PD-L1 expression and PD-1 checkpoint pathway in cancer; Autoimmune thyroid disease; Systemic lupus erythematosus; Rheumatoid arthritis; Allograft rejection; Graft-versus-host disease; Viral myocarditis","PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; CD28 dependent PI3K/Akt signaling; CD28 dependent Vav1 pathway; Nef mediated downregulation of CD28 cell surface expression","Allograft Rejection; T cell receptor and co-stimulatory signaling; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Control of immune tolerance by vasoactive intestinal peptide; Selective expression of chemokine receptors during T-cell polarization; Inflammatory response pathway; Cancer immunotherapy by CTLA4 blockade; Modulators of TCR signaling and T cell activation; Prostaglandin signaling; T-cell receptor (TCR) signaling pathway",742.3,810.4,859.9,745,787.5,578.1,1.1430872737610158,0.1929355563219058,0.23692291893106546,0.6253929254155033,0.4743000861317878,0.32394679648125785,3651]
["P10909-1","Clusterin [OS=Homo sapiens]",14,5,10,5,449,52.5,6.27,34.37,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","CLU","ENSG00000120885","Complement and coagulation cascades","Platelet degranulation ; Regulation of Complement cascade; Antimicrobial peptides; Terminal pathway of complement","Male infertility; Complement system in neuronal development and plasticity; Complement and coagulation cascades",755.2,706.1,688.9,558.1,559.1,681.8,1.1952195664257923,0.2572756711735225,0.06223099532507191,1.2059932528363622,0.25726603214420285,0.5896175516294434,1768]
["P11169","Solute carrier family 2, facilitated glucose transporter member 3 [OS=Homo sapiens]",4,2,2,2,496,53.9,7.2,4.48,"other metabolic processes;transport","plasma membrane;other membranes;other cell component","transporter activity;other molecular function","SLC2A3","ENSG00000059804","","Neutrophil degranulation; Cellular hexose transport; Vitamin C (ascorbate) metabolism; MECP2 regulates neuronal receptors and channels","Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced HIF-1 survival signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K/AKT/mTOR - VitD3 signaling; Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis",120.9,137.1,115.2,124.1,138,223.9,0.7679012345679012,-0.3810073276413847,0.3037320030319064,0.5175094457903027,0.5313492604500248,0.2746199195506195,4178]
["P11277","Spectrin beta chain, erythrocytic [OS=Homo sapiens]",9,19,54,9,2137,246.3,5.27,150.96,"cell organization and biogenesis","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity","SPTB","ENSG00000070182","","COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins","",924.3,883.9,882.7,1072.7,1069,1293.3,0.783377001455604,-0.3522213209170513,0.030236840788233705,1.5194635868451378,0.18340337703004164,0.736592671872052,1205]
["P11279","Lysosome-associated membrane glycoprotein 1 [OS=Homo sapiens]",19,8,56,8,417,44.9,8.75,149.71,"transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","LAMP1","ENSG00000185896","Autophagy; Lysosome; Phagosome; Tuberculosis","Neutrophil degranulation","Senescence and autophagy in cancer",6361.1,6378.5,6555.4,5392.4,5142.9,3420.5,1.3825792860316142,0.4673622162898233,0.04608519983281705,1.3364385249994746,0.22500783271747482,0.6478023634585541,1497]
["P11717","Cation-independent mannose-6-phosphate receptor [OS=Homo sapiens]",37,74,213,74,2491,274.2,5.94,668.87,"protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","IGF2R","ENSG00000197081","Lysosome; Endocytosis","Neutrophil degranulation; Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; Retrograde transport at the Trans-Golgi-Network","",21444,21868.5,22306.3,21247.2,20754,25221,0.9761477607100036,-0.034828548012555756,0.728582137607348,0.13752148040903014,0.8167495159159672,0.08791111425697741,6520]
["P11908","ribose-phosphate pyrophosphokinase 2 [OS=Homo sapiens]",54,16,99,7,318,34.7,6.61,304.64,"other metabolic processes","other cell component","kinase activity;other molecular function","PRPS2","ENSG00000101911","Pentose phosphate pathway; Purine metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids","5-Phosphoribose 1-diphosphate biosynthesis","Nucleotide metabolism",6708.4,6508,6890.6,5733.5,5548.9,3222.2,1.3862498793486207,0.47118733482294256,0.0838890327894761,1.0762948128345124,0.2969224894228963,0.5273569069429592,2065]
["P12259","Coagulation factor V [OS=Homo sapiens]",2,4,10,4,2224,251.5,6.05,25.4,"stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","F5","ENSG00000198734","Complement and coagulation cascades","COPII-mediated vesicle transport; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Common Pathway of Fibrin Clot Formation; Cargo concentration in the ER","Blood clotting cascade; Complement and coagulation cascades",1247.9,1158.4,1200.4,849.8,919,901.3,1.3507733792741845,0.4337856524417698,7.0887263893277966E-4,3.1494317862235577,0.0340865139339453,1.4674174122843575,152]
["P12956","X-ray repair cross-complementing protein 6 [OS=Homo sapiens]",67,39,511,39,609,69.8,6.64,1565.56,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","XRCC6","ENSG00000196419","Non-homologous end-joining","Neutrophil degranulation; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation; IRF3-mediated induction of type I IFN","Non-homologous end joining; DNA repair pathways, full network",52588.7,54247.3,53032.5,51563.2,50782.5,39669.3,1.12571559342323,0.17084238355917314,0.19920470333474694,0.7007004118550254,0.44040749445664407,0.35614529920648114,3306]
["P13073","Cytochrome c oxidase subunit 4 isoform 1, mitochondrial [OS=Homo sapiens]",36,7,70,7,169,19.6,9.51,154.87,"other metabolic processes;transport;other biological processes","other membranes;cytosol;mitochondrion;nucleus","transporter activity","COX4I1","ENSG00000131143","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly",7994.8,7644.8,7112.5,8249.7,9117.7,8181.7,0.890524519454697,-0.16727276024918017,0.07798981836990417,1.1079620910837658,0.2878927184169846,0.5407693194613239,1980]
["P13598","Intercellular adhesion molecule 2 [OS=Homo sapiens]",8,2,2,2,275,30.6,7.43,7.3,"cell adhesion","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding","ICAM2","ENSG00000108622","Cell adhesion molecules; Natural killer cell mediated cytotoxicity","Integrin cell surface interactions; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; CD209 (DC-SIGN) signaling","Complement system; Ebola virus pathway in host",393.2,412.1,398.9,396.1,407.2,325.5,1.066796598157335,0.09328512948650891,0.39157226528335887,0.40718807647296995,0.5821809778185659,0.23494198880341347,4916]
["P13747","HLA class I histocompatibility antigen, alpha chain E [OS=Homo sapiens]",38,11,40,9,358,40.1,5.95,128.11,"other biological processes","plasma membrane;other membranes","","HLA-E","","","","",1602.9,1621.2,1623.4,1898.5,1966.6,1759.2,0.8618850345820813,-0.21443265144272342,0.013494085263775046,1.8698565500373996,0.1264464989652972,0.8980931908439072,780]
["P13796","Plastin-2 [OS=Homo sapiens]",79,45,1261,36,627,70.2,5.43,3790.82,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","LCP1","ENSG00000136167","","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","",142964.3,149672.7,141363.8,137380.8,136450.6,145636.5,1.0346460360852403,0.04913729011485204,0.2791825466166916,0.5541117355653138,0.5126998073420601,0.2901368457550287,3980]
["P13995","Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [OS=Homo sapiens]",38,9,47,9,350,37.9,8.73,177.98,"other metabolic processes","mitochondrion","other molecular function","MTHFD2","ENSG00000065911","One carbon pool by folate; Metabolic pathways; Biosynthesis of cofactors","Metabolism of folate and pterines","Folate metabolism; One-carbon metabolism; Trans-sulfuration and one-carbon metabolism; Nucleotide metabolism",4645.2,4699.7,4604.6,4830.6,5119,3691.1,1.0226381344065918,0.03229573056393533,0.8252729554551539,0.08340238667187216,0.8813442477238047,0.0548544256569619,6844]
["P14174","Macrophage Migration inhibitory factor [OS=Homo sapiens]",32,3,25,3,115,12.5,7.88,55.83,"cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","MIF","ENSG00000240972; ENSG00000276701","Tyrosine metabolism; Phenylalanine metabolism; Metabolic pathways","Neutrophil degranulation; Cell surface interactions at the vascular wall; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","Adipogenesis; Spinal cord injury",2725.7,2358.3,2267.4,3106.4,3011.1,2404.9,0.8625973904064583,-0.2132407433562846,0.20846334593878704,0.6809702958745352,0.4495894350742386,0.34718390282794037,3389]
["P14373","Zinc finger protein RFP [OS=Homo sapiens]",13,5,6,5,513,58.5,6.21,17.27,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","TRIM27","ENSG00000204713; ENSG00000215641; ENSG00000229006; ENSG00000234495; ENSG00000237071","","Regulation of PTEN stability and activity; SUMOylation of ubiquitinylation proteins; Suppression of apoptosis","",396.2,346.9,379.8,445,486.3,537,0.764761969624736,-0.38691731267484425,0.019100513072091072,1.7189549667111612,0.1478873411482136,0.8300689991252572,944]
["P14678-1","Small nuclear ribonucleoprotein-associated proteins B and B' [OS=Homo sapiens]",22,7,33,7,240,24.6,11.19,98.36,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","Snrpb; SNRPB; SNRPN","ENSANAG00000024443; ENSCANG00000019461; ENSCCAG00000026002; ENSG00000125835; ENSLCNG00005019999; ENSMLEG00000022346; ENSMMUG00000010050; ENSNLEG00000029067; ENSOGAG00000016149; ENSPANG00000020362; ENSRROG00000036094; ENSSBOG00000027310","Spliceosome; Systemic lupus erythematosus","snRNP Assembly; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs","mRNA processing",3671,3316.6,3774.3,4194.5,3615.8,2313.5,1.0630296924079894,0.08818189460325353,0.7294156258554136,0.13702493727930914,0.8175584740649008,0.08748117560279577,6521]
["P14927","Cytochrome b-c1 complex subunit 7 [OS=Homo sapiens]",22,2,4,2,111,13.5,8.78,11.24,"other metabolic processes","other membranes;mitochondrion","","UQCRB","ENSG00000156467","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly",184.8,156.6,196.4,158.4,140.6,164.2,1.161053540587219,0.2154345018836361,0.14561359348248332,0.8367980803879181,0.38201355160210715,0.41792123059188985,2786]
["P15121","aldose reductase [OS=Homo sapiens]",72,18,128,16,316,35.8,6.98,425.69,"other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","AKR1B1","ENSG00000085662","Pentose and glucuronate interconversions; Fructose and mannose metabolism; Galactose metabolism; Glycerolipid metabolism; Folate biosynthesis; Metabolic pathways","Pregnenolone biosynthesis; Fructose biosynthesis","Eicosanoid metabolism via cyclooxygenases (COX); Polyol pathway; Metapathway biotransformation Phase I and II",17433.9,18269.8,18587.7,17357.7,15029.1,12368.3,1.2130773922971905,0.27867159491154087,0.09852285971418194,1.0064629908639495,0.321762100827058,0.49246511117230785,2238]
["P15374","Ubiquitin carboxyl-terminal hydrolase isozyme L3 [OS=Homo sapiens]",45,9,42,9,230,26.2,4.92,127.2,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","UCHL3","ENSG00000118939","","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; UCH proteinases; Neddylation","Proteasome degradation",4394,4991.9,4151.8,4776.4,5126.4,5348.8,0.8876249049280077,-0.17197794773091735,0.1297228101865746,0.8869836517713198,0.3641106066258348,0.4387666697835012,2604]
["P15498-1","Proto-oncogene vav [OS=Homo sapiens]",45,38,162,36,845,98.3,6.62,478.58,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","enzyme regulator activity;other molecular function","VAV1","ENSG00000141968; ENSPTRG00000010378","Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Focal adhesion; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Yersinia infection; Proteoglycans in cancer; Lipid and atherosclerosis","RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC1 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated phagocytosis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; NRAGE signals death through JNK; G alpha (12/13) signalling events; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Regulation of signaling by CBL; GPVI-mediated activation cascade; Signaling by SCF-KIT; VEGFR2 mediated vascular permeability; Erythropoietin activates RAS; CD28 dependent Vav1 pathway","Prolactin signaling pathway; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL-6 signaling pathway; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; EGF/EGFR signaling pathway; Modulators of TCR signaling and T cell activation; Regulation of actin cytoskeleton; Interferon type I signaling pathways; T-cell receptor (TCR) signaling pathway; EGFR1 signaling pathway; Kit receptor signaling pathway",22504.6,22417.1,23017.1,21633.1,20300.9,16884.7,1.1550544299687002,0.20796083778478935,0.10006466921691581,0.9997192359336244,0.32390286417468456,0.48958521163860047,2258]
["P15924-1","Desmoplakin [OS=Homo sapiens]",30,80,151,80,2871,331.6,6.81,424.21,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","DSP","ENSG00000096696","Arrhythmogenic right ventricular cardiomyopathy","Neutrophil degranulation; Formation of the cornified envelope; RND3 GTPase cycle; RND1 GTPase cycle; Apoptotic cleavage of cell adhesion  proteins","Arrhythmogenic right ventricular cardiomyopathy; Lung fibrosis; Epithelial to mesenchymal transition in colorectal cancer",15675.2,14989.5,16895.8,15221.4,15465.3,16655.7,{"$f":"AVERAGE(S1282:U1282)/AVERAGE(V1282:X1282)","v":1.0046068640373114},{"$f":"LOG(Y1282,2)","v":6.631037457398032E-3},{"$f":"TTEST(V1282:X1282,S1282:U1282,2,2)","v":0.9235974634518559},0.03451726849021725,{"$f":"AA1282*7309/AE1282","v":0.9490473584098994},0.022712115304094897,7113]
["P16035","Metalloproteinase inhibitor 2 [OS=Homo sapiens]",10,2,3,2,220,24.4,7.49,10.74,"developmental processes;other biological processes","non-structural extracellular;extracellular matrix;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","TIMP2","ENSG00000035862","","Neutrophil degranulation; Activation of Matrix Metalloproteinases","Matrix metalloproteinases; Angiogenesis; IL1 and megakaryocytes in obesity; Vitamin D receptor pathway; Burn wound healing; CCL18 signaling pathway",193.5,193.9,246.2,240.2,230.6,427.5,0.7053322943337413,-0.5036249984497415,0.2548808679309399,0.5936627626627802,0.49166647234289773,0.30832940605380044,3789]
["P16219","Short-chain specific acyl-CoA dehydrogenase, mitochondrial [OS=Homo sapiens]",6,2,5,2,412,44.3,7.99,12.11,"other metabolic processes","cytoskeleton;mitochondrion;nucleus","other molecular function","ACADS","ENSG00000122971","Fatty acid degradation; Valine, leucine and isoleucine degradation; beta-Alanine metabolism; Propanoate metabolism; Butanoate metabolism; Metabolic pathways; Carbon metabolism; Fatty acid metabolism","Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA","Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation; IL-18 signaling pathway",195.1,191.6,212.7,164.7,150.3,395.4,0.84375,-0.24511249783653147,0.6665275535689378,0.17618189258829994,0.771440995888419,0.11269728559567657,6315]
["P16402","Histone H1.3 [OS=Homo sapiens]",47,17,377,5,221,22.3,11.02,1091.22,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity","H1-3","ENSG00000124575","","Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)","",13019.5,12940.5,12624.7,11628.8,12293.5,17280.9,0.9364491107486796,-0.09472749835319923,0.650928751081379,0.1864665455418027,0.7602489999446786,0.11904414246800428,6258]
["P16619","C-C motif chemokine 3-like 1 [OS=Homo sapiens]",24,2,10,2,93,10.2,4.89,30.53,"stress response;signal transduction;other biological processes","non-structural extracellular","signal transduction activity or receptor binding","CCL3L1; CCL3L3","ENSG00000276085; ENSG00000277336; ENSG00000277768; ENSG00000277796","Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor; Chemokine signaling pathway; Toll-like receptor signaling pathway; Chagas disease; Human cytomegalovirus infection; Rheumatoid arthritis; Lipid and atherosclerosis","Chemokine receptors bind chemokines; Interleukin-10 signaling","Overview of proinflammatory and profibrotic mediators",1069.5,1099.5,940.5,1691.6,2014.3,2191.2,0.5272930762578217,-0.9233230416820106,3.819210098493593E-3,2.4180264500040978,0.07084925535504992,1.149664709945699,394]
["P16949-1","Stathmin [OS=Homo sapiens]",36,6,9,6,149,17.3,5.97,21.91,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity","LOC101348598; Stathmin; STMN1","ENSAMEG00000010298; ENSANAG00000030242; ENSBIXG00000025259; ENSBTAG00000013761; ENSCAFG00000029191; ENSCATG00000016402; ENSCCAG00000028161; ENSCHIG00000023552; ENSCJAG00000009462; ENSCSAG00000000960; ENSFCAG00000040721; ENSG00000117632; ENSGGOG00000026648; ENSLCNG00005009740; ENSMFAG00000041588; ENSMLEG00000037590; ENSMLUG00000010762; ENSMMUG00000000653; ENSMNEG00000044643; ENSNLEG00000009154; ENSOARG00000005764; ENSOGAG00000002109; ENSPANG00000010315; ENSPCTG00005008718; ENSPPAG00000038785; ENSPPYG00000001700; ENSPTRG00000000369; ENSRBIG00000033291; ENSRFEG00010003199; ENSRROG00000019821; ENSSBOG00000029102; ENSSSCG00000026257; ENSSSCG00005028094; ENSSSCG00015059883; ENSSSCG00055018660; ENSSSCG00070026240; ENSSSUG00005019081; ENSTTRG00000012495; ENSUAMG00000025721; ENSUMAG00000012809; ENSVVUG00000011613","MAPK signaling pathway; MicroRNAs in cancer","Nuclear signaling by ERBB4","MAPK signaling pathway; Microtubule cytoskeleton regulation; Retinoblastoma gene in cancer; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; EGF/EGFR signaling pathway; IL-18 signaling pathway; MAPK signaling pathway; MAPK signaling pathway",976.1,1071.4,1269.1,907.4,893.1,1262.4,1.082829997714584,0.11480676029998275,0.5993533746368873,0.22231704504989105,0.7239586539780217,0.14028623609834595,6051]
["P17096-1","High mobility group protein HMG-I/HMG-Y [OS=Homo sapiens]",48,4,8,4,107,11.7,10.32,24.83,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","HMGA1; LOC111152215","ENSAMEG00000001061; ENSCAFG00030004107; ENSCAFG00040011381; ENSCANG00000029050; ENSCATG00000042051; ENSCCAG00000024304; ENSCSAG00000009775; ENSECAG00000000734; ENSFCAG00000044104; ENSG00000137309; ENSGGOG00000025804; ENSMLEG00000042857; ENSMMUG00000019529; ENSMNEG00000005671; ENSPCTG00005015441; ENSPTRG00000040884; ENSRBIG00000030072; ENSRFEG00010017624; ENSUAMG00000015725; ENSUMAG00000010910","","Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Formation of Senescence-Associated Heterochromatin Foci (SAHF)","Adipogenesis; Adipogenesis; Pre-implantation embryo; Male infertility; 7q11.23 copy number variation syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Orexin receptor pathway; Senescence and autophagy in cancer; Adipogenesis",1211.2,1349.4,1348.5,762.8,836.2,978.3,1.5167423272416871,0.6009760132146623,0.004743254345831143,2.323923586706066,0.07653078590216297,1.116163826834925,453]
["P17152","Transmembrane protein 11, mitochondrial [OS=Homo sapiens]",14,3,9,3,192,21.5,7.36,21.08,"cell organization and biogenesis","plasma membrane;other membranes;mitochondrion","","TMEM11","ENSG00000178307","","Cristae formation","",1299.4,1334.6,1336.6,1303.4,1190.6,847.1,1.1884110023644907,0.24903386688577303,0.20235618743611086,0.6938835116664005,0.4436176886534296,0.3529911452744141,3334]
["P17612","cAMP-dependent protein kinase catalytic subunit alpha [OS=Homo sapiens]",37,15,43,9,351,40.6,8.79,135.85,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","kinase activity;other molecular function","PRKACA","ENSG00000072062; ENSG00000288516","Endocrine resistance; MAPK signaling pathway; Ras signaling pathway; Calcium signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Oocyte meiosis; Autophagy; Longevity regulating pathway; Longevity regulating pathway; Adrenergic signaling in cardiomyocytes; Vascular smooth muscle contraction; Wnt signaling pathway; Hedgehog signaling pathway; Apelin signaling pathway; Tight junction; Gap junction; Platelet activation; Circadian entrainment; Thermogenesis; Long-term potentiation; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; GABAergic synapse; Dopaminergic synapse; Olfactory transduction; Taste transduction; Inflammatory mediator regulation of TRP channels; Insulin signaling pathway; Insulin secretion; GnRH signaling pathway; Ovarian steroidogenesis; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Melanogenesis; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Regulation of lipolysis in adipocytes; Renin secretion; Aldosterone synthesis and secretion; Relaxin signaling pathway; Cortisol synthesis and secretion; Parathyroid hormone synthesis, secretion and action; Cushing syndrome; Growth hormone synthesis, secretion and action; Endocrine and other factor-regulated calcium reabsorption; Vasopressin-regulated water reabsorption; Salivary secretion; Gastric acid secretion; Bile secretion; Parkinson disease; Prion disease; Cocaine addiction; Amphetamine addiction; Morphine addiction; Alcoholism; Vibrio cholerae infection; Amoebiasis; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; Chemical carcinogenesis; Dilated cardiomyopathy","Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; MAPK6/MAPK4 signaling; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Interleukin-3, Interleukin-5 and GM-CSF signaling; Factors involved in megakaryocyte development and platelet production; VEGFA-VEGFR2 Pathway; RET signaling; ROBO receptors bind AKAP5; FCGR3A-mediated IL10 synthesis; Triglyceride catabolism; ADORA2B mediated anti-inflammatory cytokines production; Ion homeostasis; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; Regulation of MECP2 expression and activity; PKA activation; PKA activation in glucagon signalling; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; CD209 (DC-SIGN) signaling; Rap1 signalling; HDL assembly; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase; Loss of phosphorylation of MECP2 at T308; PKA-mediated phosphorylation of key metabolic factors","Nicotine effect on dopaminergic neurons; Sterol regulatory element-binding proteins (SREBP) signaling; Follicle stimulating hormone (FSH) signaling pathway; Microtubule cytoskeleton regulation; Dopamine metabolism; Common pathways underlying drug addiction; Complement system; Mesodermal commitment pathway; IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Mesodermal commitment pathway; G protein signaling pathways; MAPK signaling pathway; Cannabinoid receptor signaling; Lipid metabolism pathway; Ras signaling; Hedgehog signaling pathway; Thermogenesis; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Neuroinflammation and glutamatergic signaling; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways; Estrogen signaling pathway",5674.4,5979.2,5778.5,5135,5190.1,3977.9,1.2187722855345031,0.28542859911756163,0.0617094526743048,1.2096483054991343,0.2575867444868611,0.5890764896986074,1751]
["P17931","Galectin-3 [OS=Homo sapiens]",6,1,1,1,250,26.1,8.56,3.66,"RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","LGALS3","ENSG00000131981","","Neutrophil degranulation; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; Advanced glycosylation endproduct receptor signaling; RUNX2 regulates genes involved in differentiation of myeloid cells","AGE/RAGE pathway; Spinal cord injury",67.5,70.5,82.7,87.1,78.4,143.9,0.7133160956690369,-0.4873865671694217,0.2329594968722551,0.6327195803213806,0.4720546056665684,0.32600776075577076,3607]
["P18031","Tyrosine-protein phosphatase non-receptor type 1 [OS=Homo sapiens]",46,18,62,18,435,49.9,6.27,198.79,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","PTPN1","ENSG00000196396","Adherens junction; Insulin signaling pathway; Insulin resistance; Chemical carcinogenesis","MECP2 regulates neuronal receptors and channels; Growth hormone receptor signaling; Regulation of IFNG signaling; Regulation of IFNA signaling; Negative regulation of MET activity; Integrin signaling; PTK6 Down-Regulation","Leptin signaling pathway; Prolactin signaling pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Insulin signaling",8162.1,8079.8,8147.7,7986.6,8039.4,9097.7,0.9707805777015328,-0.042782849947945276,0.5369569204661553,0.2700605559286051,0.6780611837745558,0.168731116491632,5788]
["P18583-5","Isoform D of Protein SON [OS=Homo sapiens]",24,37,125,6,2459,266.9,5.73,394.66,"","","","SON","","","","",11978.2,12078,12112.8,15412.3,15806,14191.3,0.7965055847221734,-0.32824361760289394,0.003216149802166123,2.4926637308380903,0.06584548712614059,1.1814739850663105,357]
["P18827","syndecan-1 [OS=Homo sapiens]",16,5,34,5,310,32.4,4.63,131.88,"cell-cell signaling;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SDC1","ENSG00000115884","ECM-receptor interaction; Cell adhesion molecules; Malaria; Proteoglycans in cancer; Fluid shear stress and atherosclerosis","Cell surface interactions at the vascular wall; A tetrasaccharide linker sequence is required for GAG synthesis; HS-GAG biosynthesis; HS-GAG degradation; Defective B4GALT7 causes EDS, progeroid type; Defective B3GAT3 causes JDSSDHD; Defective EXT2 causes exostoses 2; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Defective B3GALT6 causes EDSP2 and SEMDJL1; Retinoid metabolism and transport; Syndecan interactions; Other interleukin signaling","",3997.3,4155.6,3896.3,4475.8,5044,2149.4,1.0325643574538101,0.0462317044397668,0.8935523612715432,0.048879993191905086,0.9269052240326013,0.03296467015315586,7046]
["P18850","Cyclic AMP-dependent transcription factor ATF-6 alpha [OS=Homo sapiens]",2,1,1,1,670,74.5,8.22,0,"stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","ATF6","ENSG00000118217","Protein processing in endoplasmic reticulum; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Lipid and atherosclerosis","ATF4 activates genes in response to endoplasmic reticulum  stress; ATF6 (ATF6-alpha) activates chaperone genes","Sterol regulatory element-binding proteins (SREBP) signaling; Alzheimer's disease and miRNA effects; Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling pathway; Unfolded protein response; Alzheimer's disease",31,27.6,31,36.4,37.6,85,0.5635220125786163,-0.8274561281141136,0.22279053745194596,0.6521032588289871,0.4643216533322706,0.3331810628265167,3507]
["P19388","DNA-directed RNA polymerases I, II, and III subunit RPABC1 [OS=Homo sapiens]",21,4,11,4,210,24.5,5.95,29.4,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR2E","ENSG00000099817","RNA polymerase; Cytosolic DNA-sensing pathway; Huntington disease","mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; RNA Polymerase I Promoter Escape; Inhibition of DNA recombination at telomere; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Viral Messenger RNA Synthesis; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM","Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway",1138.9,961.1,1001.5,1571.6,1482.2,1502.5,0.6807058358756007,-0.5548966164873831,1.2922517215536904E-3,2.888652880587418,0.044343041468713255,1.3531745221421827,213]
["P19397","Leukocyte surface antigen CD53 [OS=Homo sapiens]",13,4,10,4,219,24.3,7.52,23.32,"signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","CD53","ENSG00000143119","","Neutrophil degranulation","",1091.6,1164.9,1171.3,1157.8,981.6,2309.8,0.7704306392160388,-0.37626301610101864,0.4603338577450684,0.3369270813930375,0.625270426734567,0.20393211155555846,5381]
["P19784","casein kinase II subunit alpha' [OS=Homo sapiens]",51,14,25,13,350,41.2,8.56,89.99,"cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","CSNK2A2","ENSG00000070770","Ribosome biogenesis in eukaryotes; NF-kappa B signaling pathway; Mitophagy; Wnt signaling pathway; Adherens junction; Alzheimer disease; Prion disease; Pathways of neurodegeneration; Measles; PD-L1 expression and PD-1 checkpoint pathway in cancer","ROS sensing by NFE2L2; Regulation of PTEN stability and activity; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of TP53 Activity through Phosphorylation; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Receptor Mediated Mitophagy; Condensation of Prometaphase Chromosomes; Synthesis of PC","Alzheimer's disease and miRNA effects; Allograft Rejection; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Malignant pleural mesothelioma; Alzheimer's disease",2150.6,2247.1,2205.4,1917.2,1925.8,2333.4,1.0690855514539215,0.09637730649130787,0.36752505422291276,0.4347130496685631,0.5668370165256952,0.24654179648399127,4739]
["P20036","HLA class II histocompatibility antigen, DP alpha 1 chain [OS=Homo sapiens]",18,3,4,3,260,29.4,5.21,16,"stress response;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","HLA-DPA1","ENSG00000168384; ENSG00000206291; ENSG00000224103; ENSG00000228163; ENSG00000229685; ENSG00000231389; ENSG00000235844; ENSG00000236177","Phagosome; Cell adhesion molecules; Antigen processing and presentation; Hematopoietic cell lineage; Th1 and Th2 cell differentiation; Th17 cell differentiation; Intestinal immune network for IgA production; Type I diabetes mellitus; Leishmaniasis; Toxoplasmosis; Staphylococcus aureus infection; Tuberculosis; Influenza A; Human T-cell leukemia virus 1 infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Asthma; Autoimmune thyroid disease; Inflammatory bowel disease; Systemic lupus erythematosus; Rheumatoid arthritis; Allograft rejection; Graft-versus-host disease; Viral myocarditis","Downstream TCR signaling; Generation of second messenger molecules; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling","Allograft Rejection; Ebola virus pathway in host",384.5,371.3,375.6,298.3,325,639.9,0.8956618112729579,-0.15897400021646188,0.7094072504108826,0.14910437718724104,0.8032622142917337,0.09514266190570718,6455]
["P20073-1","Annexin A7 [OS=Homo sapiens]",34,16,117,16,488,52.7,5.68,287.16,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ANXA7","ENSG00000138279","Amyotrophic lateral sclerosis","","",10632,10824.2,11060.6,11141.7,9707.5,10186.5,1.0477224615523415,0.06725660201828706,0.3240636657048742,0.4893696597066525,0.5441261963328569,0.26430036498007786,4353]
["P20340-2","Isoform 2 of Ras-related protein Rab-6A [OS=Homo sapiens]",45,11,48,1,208,23.5,5.54,102.09,"","","","RAB6A","","","","",202.9,186.4,218,178.9,162.4,257,1.0150426207588166,0.02154030619511729,0.9265422317751348,0.03313478076072974,0.9510036753327427,0.02181780464655565,7121]
["P20701-1","Integrin alpha-L [OS=Homo sapiens]",11,8,11,8,1170,128.7,5.63,35.18,"cell adhesion;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","ITGAL","ENSG00000005844","Rap1 signaling pathway; Cell adhesion molecules; Neutrophil extracellular trap formation; Natural killer cell mediated cytotoxicity; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Malaria; Staphylococcus aureus infection; Human T-cell leukemia virus 1 infection; Epstein-Barr virus infection; Rheumatoid arthritis; Viral myocarditis","Neutrophil degranulation; Integrin cell surface interactions; Cell surface interactions at the vascular wall; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; RUNX3 Regulates Immune Response and Cell Migration","Integrin-mediated cell adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Acute viral myocarditis; Cells and molecules involved in local acute inflammatory response ; Overview of leukocyte-intrinsic Hippo pathway functions; CCL18 signaling pathway",1314.3,1431.2,1397.6,1152.1,1154.8,626.2,1.4125328151102934,0.4982843837380693,0.08751671560567481,1.0579089892407278,0.3031562437734015,0.5183334826544476,2110]
["P20810-6","Isoform 6 of Calpastatin [OS=Homo sapiens]",65,41,192,1,791,84.9,5.36,471.87,"","","","CAST","","","","",18579.7,18288.2,19022.8,21697.8,22478.2,21107.5,0.8561229100768187,-0.22411016154480526,2.2566827879655937E-3,2.646529483508895,0.0551641956429449,1.2583427099493514,299]
["P21333-2","Isoform 2 of Filamin-A [OS=Homo sapiens]",58,114,509,103,2639,279.8,6.05,1811.48,"","","","FLNA","","","","",59830.7,61535.2,58959.2,48158.1,49246.1,54612.5,1.1862190140951616,0.24637040227685741,0.011487731266062676,1.939765732488193,0.11661642753285013,0.9332402670354885,720]
["P21359-1","Neurofibromin [OS=Homo sapiens]",3,6,6,6,2839,319.2,7.39,17.78,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","NF1","ENSG00000196712","EGFR tyrosine kinase inhibitor resistance; MAPK signaling pathway; Ras signaling pathway","Regulation of RAS by GAPs; RAS signaling downstream of NF1 loss-of-function variants","Pilocytic astrocytoma; Glioblastoma signaling pathways; Aryl hydrocarbon receptor Netpath; MECP2 and associated Rett syndrome; MAPK signaling pathway; Ras signaling; Transcription co-factors SKI and SKIL protein partners; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Melanoma; EGFR tyrosine kinase inhibitor resistance",294.2,300.2,325.2,286.4,312.5,522.7,0.8199001426533524,-0.28647988329244306,0.4223036192879674,0.37437519650533846,0.5994595364878139,0.22224012644860017,5149]
["P21964-1","Catechol O-methyltransferase [OS=Homo sapiens]",44,9,29,9,271,30,5.47,77.17,"other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","COMT","ENSG00000093010","Steroid hormone biosynthesis; Tyrosine metabolism; Metabolic pathways; Dopaminergic synapse","Potential therapeutics for SARS; Methylation; Enzymatic degradation of dopamine by COMT; Enzymatic degradation of Dopamine by monoamine oxidase","Dopamine metabolism; MTHFR deficiency; 22q11.2 copy number variation syndrome; Biogenic amine synthesis; Estrogen metabolism; Metapathway biotransformation Phase I and II; Methylation pathways",3170.7,3341.8,3369.2,3229.1,3047.8,2946,1.0714308948378495,0.09953880205382949,0.10113519580363874,0.9950976803804031,0.3252077193703456,0.48783915422140095,2273]
["P22304","iduronate 2-sulfatase [OS=Homo sapiens]",9,3,6,3,550,61.8,5.45,24.23,"other metabolic processes","other cytoplasmic organelle","other molecular function","IDS","ENSG00000010404","Glycosaminoglycan degradation; Metabolic pathways; Lysosome","HS-GAG degradation; CS/DS degradation; MPS II - Hunter syndrome","Glycosaminoglycan degradation",233.9,236.6,223,212.4,249.1,432.3,0.775900648914746,-0.3660561621840451,0.38264415500321725,0.4172049162538732,0.5761734917425865,0.23944672636581618,4854]
["P22392-2","Isoform 3 of Nucleoside diphosphate kinase B [OS=Homo sapiens]",81,15,248,2,267,30.1,8.92,730.63,"","","","NME2","","","","",39417.3,40152.2,36981,42051.2,38268.9,30943.6,1.0475159463508763,0.06697220625992086,0.6314288645429222,0.19967556906213121,0.7475078670139648,0.12638423232423485,6174]
["P22695","Cytochrome b-c1 complex subunit 2, mitochondrial [OS=Homo sapiens]",48,17,119,17,453,48.4,8.63,367.02,"protein metabolism;other metabolic processes;other biological processes","other membranes;mitochondrion;nucleus","other molecular function","UQCRC2","ENSG00000140740","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly",13463.6,13666.5,14070.8,12580.4,11553.9,12864,1.1135890027379634,0.15521686901682175,0.03252637597241646,1.4877643222963437,0.1885291688995971,0.7246214469854524,1261]
["P23229-1","integrin alpha-6 [OS=Homo sapiens]",2,2,2,2,1130,126.5,6.61,6.6,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","ITGA6","ENSG00000091409","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Cell adhesion molecules; Hematopoietic cell lineage; Regulation of actin cytoskeleton; Toxoplasmosis; Human papillomavirus infection; Pathways in cancer; Small cell lung cancer; Hypertrophic cardiomyopathy; Arrhythmogenic right ventricular cardiomyopathy; Dilated cardiomyopathy","Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; Syndecan interactions; Laminin interactions; Basigin interactions; Type I hemidesmosome assembly","Integrin-mediated cell adhesion; Arrhythmogenic right ventricular cardiomyopathy; Alpha 6 beta 4 signaling pathway; Mammary gland development pathway - Embryonic development (Stage 1 of 4); Focal adhesion; Regulation of apoptosis by parathyroid hormone-related protein; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ebola virus pathway in host; Small cell lung cancer; Malignant pleural mesothelioma",115,131.9,124.9,127.8,131.9,155.5,0.8954720616570327,-0.15927967343839924,0.21875096295475635,0.6600500265112879,0.4602333875176495,0.33702187873839473,3474]
["P23284","peptidyl-prolyl cis-trans isomerase B [OS=Homo sapiens]",64,18,453,16,216,23.7,9.41,1131.48,"protein metabolism;other metabolic processes;developmental processes;other biological processes","ER/Golgi;nucleus;other cell component","other molecular function","PPIB","ENSG00000166794","","Collagen biosynthesis and modifying enzymes","Prolactin signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta",71499.7,72512.8,70027.1,68583.8,66200.7,65807.1,1.0670416906789717,0.09361654519774533,0.016501323179068345,1.7824812299480421,0.13847091976556894,0.8586414230717324,871]
["P23434","Glycine cleavage system H protein, mitochondrial [OS=Homo sapiens]",39,3,11,3,173,18.9,4.88,37.11,"protein metabolism;other metabolic processes","mitochondrion;other cell component","other molecular function","GCSH","ENSG00000140905","Glycine, serine and threonine metabolism; Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism","Glycine degradation","",965.4,922.8,910.7,931.4,933.5,597,1.1368861448474754,0.18508778062541478,0.37660123876706414,0.424118255777624,0.5726187755665637,0.24213441602229796,4807]
["P23468-1","Receptor-type tyrosine-protein phosphatase delta [OS=Homo sapiens]",2,2,2,2,1912,214.6,6.57,8.19,"cell adhesion;cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","PTPRD","ENSG00000153707; ENSG00000282932","","Synaptic adhesion-like molecules; Receptor-type tyrosine-protein phosphatases","",46.7,38.7,44.1,32.4,41.1,51,1.040160642570281,0.05680635561847272,0.7904498879011804,0.10212565779735851,0.858581992966225,0.06621822421601573,6729]
["P23634-1","Plasma membrane calcium-transporting ATPase 4 [OS=Homo sapiens]",21,20,33,10,1241,137.8,6.6,122.21,"stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","transporter activity;enzyme regulator activity;other molecular function","ATP2B4","ENSG00000058668","Calcium signaling pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Adrenergic signaling in cardiomyocytes; Aldosterone synthesis and secretion; Endocrine and other factor-regulated calcium reabsorption; Salivary secretion; Pancreatic secretion; Mineral absorption","Ion homeostasis; Ion transport by P-type ATPases; Reduction of cytosolic Ca++ levels","Vitamin D-sensitive calcium signaling in depression",906.3,931.7,912.9,769.9,845.3,698.4,1.1890127939142463,0.24976423873145165,0.027709605773081427,1.5573696529183552,0.1768816668955914,0.7523171777102889,1145]
["P24539","ATP synthase F(0) complex subunit B1, mitochondrial [OS=Homo sapiens]",43,12,65,12,256,28.9,9.36,184.57,"other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","ATP5PB","ENSG00000116459","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation",8089.7,7492.1,7319.6,6015.5,6791.4,6791.5,1.1685341660543718,0.2246999168135961,0.03416091561254144,1.4664704974635585,0.19310296381443573,0.7142110604599796,1293]
["P24752","Acetyl-CoA acetyltransferase, mitochondrial [OS=Homo sapiens]",64,25,217,25,427,45.2,8.85,726.81,"other metabolic processes;stress response;developmental processes;other biological processes","mitochondrion","other molecular function","ACAT1","ENSG00000075239","Fatty acid degradation; Valine, leucine and isoleucine degradation; Lysine degradation; Tryptophan metabolism; Pyruvate metabolism; Glyoxylate and dicarboxylate metabolism; Butanoate metabolism; Terpenoid backbone biosynthesis; Metabolic pathways; Carbon metabolism; Fatty acid metabolism; Fat digestion and absorption","Branched-chain amino acid catabolism; Utilization of Ketone Bodies; Synthesis of Ketone Bodies","Fatty acid beta-oxidation; Ketone bodies synthesis and degradation; Tryptophan metabolism; SARS-CoV-2 and COVID-19 pathway",26691.2,28941,27138.3,25531.4,24854.7,34794.1,0.9717105618441844,-0.04140144481728248,0.818550576770497,0.08695448114668869,0.8768556596241481,0.05707189054262192,6823]
["P25440-1","Bromodomain-containing protein 2 [OS=Homo sapiens]",3,2,2,2,801,88,9.09,5.99,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","kinase activity;other molecular function","BRD2","ENSG00000204256; ENSG00000215077; ENSG00000234507; ENSG00000234704; ENSG00000235307; ENSGGOG00000043461","","RUNX3 regulates p14-ARF","",144.3,147.4,164.2,679.3,697.2,375.8,0.26017234491810765,-1.942460476297842,0.014414145501752225,1.8412110983242274,0.13038736320830077,0.8847644972148404,808]
["P25786-1","Proteasome subunit alpha type-1 [OS=Homo sapiens]",64,17,151,17,263,29.5,6.61,439.06,"protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","PSMA1","ENSCANG00000029071; ENSCATG00000014932; ENSCJAG00000009850; ENSCPOG00000015226; ENSG00000129084; ENSGGOG00000001416; ENSHGLG00000008245; ENSMFAG00000036829; ENSMLEG00000030594; ENSMMUG00000016446; ENSMNEG00000005235; ENSOCUG00000000439; ENSPANG00000016448; ENSPPYG00000003466; ENSPTRG00000003385; ENSRBIG00000037598; ENSRROG00000037748; ENSSSCG00000013391; ENSSTOG00000006270; ENSTSYG00000003869","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration","ER-Phagosome pathway; MAPK6/MAPK4 signaling; Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Downstream TCR signaling; UCH proteinases; Regulation of expression of SLITs and ROBOs; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease",15589.4,15843.7,15434,16137.9,16086.5,14506.1,1.0029231444131776,0.004211054183106646,0.9378537342886523,0.027864888000980623,0.9587095026455608,0.01831296791808827,7150]
["P26006","Integrin alpha-3 [OS=Homo sapiens]",1,1,1,1,1051,116.5,6.77,1.82,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","ITGA3","ENSG00000005884","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Hematopoietic cell lineage; Regulation of actin cytoskeleton; Human papillomavirus infection; Pathways in cancer; Small cell lung cancer; Hypertrophic cardiomyopathy; Arrhythmogenic right ventricular cardiomyopathy; Dilated cardiomyopathy","Integrin cell surface interactions; Laminin interactions; MET activates PTK2 signaling; Basigin interactions","Integrin-mediated cell adhesion; Arrhythmogenic right ventricular cardiomyopathy; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ebola virus pathway in host; Small cell lung cancer; Nephrotic syndrome; Genes controlling nephrogenesis; Malignant pleural mesothelioma",79.6,73.7,70.1,65.1,65.7,93.6,0.9955436720142603,-0.006443490125477907,0.9744983017154814,0.011218913402427312,0.9820223476131881,0.007878628980200662,7253]
["P26358-1","DNA (cytosine-5)-methyltransferase 1 [OS=Homo sapiens]",36,45,110,1,1616,183.1,7.75,300.92,"cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DNMT1","ENSG00000130816","Cysteine and methionine metabolism; Metabolic pathways; MicroRNAs in cancer","NoRC negatively regulates rRNA expression; PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; SUMOylation of DNA methylation proteins","Trans-sulfuration pathway; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration and one-carbon metabolism; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; MTHFR deficiency",402.7,389.3,374.5,622.5,699,270,0.7329563305058121,-0.4482008496517218,0.34476318037040604,0.4624791216634472,0.5552829628310485,0.25548565132839135,4538]
["P26373-1","60S ribosomal protein L13 [OS=Homo sapiens]",39,10,37,10,211,24.2,11.65,99.04,"protein metabolism;other metabolic processes;developmental processes","cytosol;ER/Golgi;translational apparatus;nucleus","other molecular function","RPL13","ENSG00000167526","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",6225.3,5107.8,5194.8,5994.4,6414.3,5247.7,0.9360854987426656,-0.09528778839197197,0.48974396442951756,0.31003090751517076,0.6481149078427202,0.18834798885487497,5523]
["P26885","Peptidyl-prolyl cis-trans isomerase FKBP2 [OS=Homo sapiens]",44,4,14,4,142,15.6,9.13,41.59,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","FKBP2","ENSG00000173486","","","Complement system",1612.1,1560.7,1562.2,1422,1491.2,2248,0.9174223048903356,-0.124342111422696,0.6204323229606286,0.20730558462089327,0.7400032389881257,0.13076637936146782,6128]
["P27540","Aryl hydrocarbon receptor nuclear translocator [OS=Homo sapiens]",4,3,4,3,789,86.6,6.54,8.99,"stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","ARNT","ENSG00000143437","HIF-1 signaling pathway; Cushing syndrome; Pathways in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Renal cell carcinoma","PPARA activates gene expression; Endogenous sterols; Xenobiotics; Aryl hydrocarbon receptor signalling; Regulation of gene expression by Hypoxia-inducible Factor","Angiogenesis; Aryl hydrocarbon receptor Netpath; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; Type 2 papillary renal cell carcinoma",373,360.5,343.9,386.6,382.1,407.9,0.9156892741798404,-0.12706997107420942,0.04626184416450774,1.3347770586707686,0.22556892528244635,0.646720729635075,1499]
["P27695","DNA-(apurinic or apyrimidinic site) lyase [OS=Homo sapiens]",61,17,74,17,318,35.5,8.12,255.72,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytoskeleton;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component","nucleic acid binding activity;other molecular function","APEX1","ENSG00000100823","Base excision repair","Displacement of DNA glycosylase by APEX1; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Abasic sugar-phosphate removal via the single-nucleotide replacement pathway","Thyroid stimulating hormone (TSH) signaling pathway; Spinal cord injury; Base excision repair; DNA repair pathways, full network",9178.6,8833.6,8380.1,8739.9,9806.9,6166.9,1.0679218409222417,0.09480606290551244,0.6391779808610532,0.19437819451267266,0.7529011864808118,0.12326201846344832,6205]
["P27986","Phosphatidylinositol 3-kinase regulatory subunit alpha [OS=Homo sapiens]",16,10,16,9,724,83.5,6.16,43.18,"cell adhesion;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","PIK3R1","ENSG00000145675","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; Platinum drug resistance; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Phosphatidylinositol signaling system; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Osteoclast differentiation; Focal adhesion; Signaling pathways regulating pluripotency of stem cells; Platelet activation; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; TNF signaling pathway; Leukocyte transendothelial migration; Neurotrophin signaling pathway; Cholinergic synapse; Inflammatory mediator regulation of TRP channels; Regulation of actin cytoskeleton; Insulin signaling pathway; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Prolactin signaling pathway; Thyroid hormone signaling pathway; Regulation of lipolysis in adipocytes; Relaxin signaling pathway; GnRH secretion; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Aldosterone-regulated sodium reabsorption; Carbohydrate digestion and absorption; Alzheimer disease; Spinocerebellar ataxia; Prion disease; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection; Chagas disease; Amoebiasis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Signaling by FGFR1 in disease; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; G alpha (q) signalling events; RAC1 GTPase cycle; VEGFA-VEGFR2 Pathway; RHOC GTPase cycle; CDC42 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; RAF/MAP kinase cascade; PI3K Cascade; PI-3K cascade:FGFR4; Signaling by FGFR4 in disease; Downstream TCR signaling; RND2 GTPase cycle; RHOF GTPase cycle; Extra-nuclear estrogen signaling; RHOV GTPase cycle; Signaling by ALK fusions and activated point mutants; RHOU GTPase cycle; Synthesis of PIPs at the plasma membrane; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Regulation of signaling by CBL; Nephrin family interactions; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; Costimulation by the CD28 family; CD28 dependent PI3K/Akt signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; RND3 GTPase cycle; RND1 GTPase cycle; Interleukin-4 and Interleukin-13 signaling; PI3K events in ERBB4 signaling; PI3K events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; GAB1 signalosome; Signaling by cytosolic FGFR1 fusion mutants; PI-3K cascade:FGFR1; PI-3K cascade:FGFR2; Signaling by FGFR2 in disease; PI-3K cascade:FGFR3; Signaling by FGFR3 point mutants in cancer; FLT3 Signaling; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FGFR3 fusions in cancer; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants; GP1b-IX-V activation signalling; MET activates PI3K/AKT signaling; Activated NTRK3 signals through PI3K; Activated NTRK2 signals through PI3K","IL-5 signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase (AMPK) signaling; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Apoptosis; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; IL-6 signaling pathway; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Ebola virus pathway in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Overview of interferons-mediated signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; IL-18 signaling pathway; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; Modulators of TCR signaling and T cell activation; Orexin receptor pathway; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; Interferon type I signaling pathways; Notch signaling pathway (Netpath); ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway",1710.4,1529.4,1696.6,1477,1613.2,1440.8,1.0894725226219377,0.12362981097703421,0.1596517571963692,0.7968262970651124,0.3981216968093697,0.39998415361957496,2931]
["P28072","Proteasome subunit beta type-6 [OS=Homo sapiens]",31,7,35,7,239,25.3,4.92,93.1,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","PSMB6","ENSG00000142507","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease",3224.3,3418.6,3720.8,3397.3,3005.1,2059.3,1.224777526974485,0.2925197166734687,0.2079165346096497,0.6821109719278248,0.449338247031913,0.3474266133055748,3382]
["P28288","ATP-binding cassette sub-family D member 3 [OS=Homo sapiens]",22,11,28,11,659,75.4,9.36,86.64,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ABCD3","ENSG00000117528","ABC transporters; Peroxisome","RHOA GTPase cycle; RHOC GTPase cycle; Class I peroxisomal membrane protein import; ABC transporters in lipid homeostasis","Nuclear receptors in lipid metabolism and toxicity; Fragile X syndrome",1928.1,1946.6,1914,1780.8,1746.5,2376,0.980587129232802,-0.028282269337463993,0.8609613585811806,0.06501633998833999,0.9058250424456383,0.04295567697872229,6947]
["P28347","Transcriptional enhancer factor TEF-1 [OS=Homo sapiens]",10,2,2,2,426,47.9,8.15,5.03,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TEAD1","ENSG00000187079","Hippo signaling pathway; Hippo signaling pathway","YAP1- and WWTR1 (TAZ)-stimulated gene expression; EGR2 and SOX10-mediated initiation of Schwann cell myelination; RUNX3 regulates YAP1-mediated transcription","Mesodermal commitment pathway; Mesodermal commitment pathway; miR-509-3p alteration of YAP1/ECM axis; Transcription co-factors SKI and SKIL protein partners; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Overview of leukocyte-intrinsic Hippo pathway functions; Malignant pleural mesothelioma",82.6,81.6,103.4,75.2,89.3,51.8,1.2371705963938973,0.3070444506794821,0.2599966734691922,0.5850322085800118,0.4964252054300746,0.30414617580084485,3828]
["P28702","Retinoic acid receptor RXR-beta [OS=Homo sapiens]",12,4,6,4,533,56.9,8.18,23.05,"signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RXRB","ENSG00000204231; ENSG00000206289; ENSG00000227322; ENSG00000228333; ENSG00000231321; ENSG00000235712","PPAR signaling pathway; Th17 cell differentiation; Thyroid hormone signaling pathway; Adipocytokine signaling pathway; Parathyroid hormone synthesis, secretion and action; Pathways in cancer; Transcriptional misregulation in cancer; Chemical carcinogenesis; Thyroid cancer; Small cell lung cancer; Non-small cell lung cancer; Gastric cancer; Lipid and atherosclerosis","NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; PPARA activates gene expression; Nuclear Receptor transcription pathway; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis; Signaling by Retinoic Acid; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose; NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake ; NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis","Vitamin D metabolism; Nuclear receptors; PPAR signaling pathway; Non-small cell lung cancer; Non-genomic actions of 1,25 dihydroxyvitamin D3; Small cell lung cancer; IL-18 signaling pathway; Vitamin A and carotenoid metabolism",506,518.1,492.3,627.3,661.4,618.3,0.7951756685894075,-0.3306544820294744,9.9318541025573883E-4,3.0029696687912186,0.03923887655977943,1.4062834353102596,185]
["P29218-1","Inositol monophosphatase 1 [OS=Homo sapiens]",35,8,29,8,277,30.2,5.26,96.42,"other metabolic processes;signal transduction","cytosol;other cell component","other molecular function","IMPA1","ENSG00000133731","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of IP2, IP, and Ins in the cytosol","Integrated breast cancer pathway",2215.8,2208.4,2186.6,2174.2,2075.2,1677.9,1.1153138865925467,0.15744978987828556,0.20803568344425347,0.6818621660286712,0.4490646220596718,0.34769115791761473,3386]
["P29466-1","caspase-1 [OS=Homo sapiens]",45,15,58,15,404,45.1,5.91,200.9,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;other cell component","enzyme regulator activity;other molecular function","CASP1","ENSG00000137752","Necroptosis; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; Amyotrophic lateral sclerosis; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Legionellosis; Yersinia infection; Influenza A; Coronavirus disease; Lipid and atherosclerosis","The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; NOD1/2 Signaling Pathway; TP53 Regulates Transcription of Caspase Activators and Caspases; The AIM2 inflammasome; Pyroptosis; Interleukin-37 signaling; Interleukin-1 processing; The IPAF inflammasome","Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis modulation and signaling; Parkin-ubiquitin proteasomal system pathway; Amyotrophic lateral sclerosis (ALS); Apoptosis; Cytosolic DNA-sensing pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Malignant pleural mesothelioma; Prostaglandin signaling",5491.6,5487.9,5350.6,5615.7,5708.6,4189.2,1.0526380249460148,0.07400941604649329,0.6108838889774008,0.21404132849457075,0.7318390992518968,0.13558439160298524,6101]
["P29597","Non-receptor tyrosine-protein kinase TYK2 [OS=Homo sapiens]",4,6,7,5,1187,133.6,7.15,21.06,"protein metabolism;other metabolic processes;stress response;signal transduction","other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","TYK2","ENSG00000105397","Necroptosis; Osteoclast differentiation; NOD-like receptor signaling pathway; JAK-STAT signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease","Potential therapeutics for SARS; Interleukin-4 and Interleukin-13 signaling; Interleukin-10 signaling; Interleukin-6 signaling; Regulation of IFNA signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; IL-6-type cytokine receptor ligand interactions; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-12 signaling; Interleukin-23 signaling; Interleukin-27 signaling; Other interleukin signaling","Type III interferon signaling; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; IL-6 signaling pathway; IL-4 signaling pathway; Immune response to tuberculosis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Overview of interferons-mediated signaling pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Interferon type I signaling pathways",677.3,676.2,620.1,705.7,732.4,1347.3,0.7085517340417894,-0.4970549012772742,0.2678137904912146,0.5721670636943017,0.5042377626739536,0.2973646328626727,3882]
["P30041","Peroxiredoxin-6 [OS=Homo sapiens]",73,18,185,18,224,25,6.38,666,"other metabolic processes;stress response;other biological processes","non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PRDX6","ENSG00000117592","Glutathione metabolism; Metabolic pathways","Neutrophil degranulation; Detoxification of Reactive Oxygen Species","Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling pathway",24292.5,23548.6,22205.6,23336.3,23487.2,18963.7,1.0647466376437968,0.0905101740185353,0.42608972056346467,0.370498943049992,0.6022606396438529,0.22021551893808877,5171]
["P30085-1","UMP-CMP kinase [OS=Homo sapiens]",47,10,43,10,196,22.2,5.57,139.27,"other metabolic processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","CMPK1","ENSG00000162368","Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors","Interconversion of nucleotide di- and triphosphates","Pyrimidine metabolism",6644,5781,5739.5,6616.8,6732.5,5424.5,0.9675451959645889,-0.04759904089537632,0.711623102081911,0.14774996145399838,0.8051475624019641,0.0941245175651095,6460]
["P30154","Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [OS=Homo sapiens]",26,13,56,6,601,66.2,4.94,165.5,"protein metabolism;other metabolic processes;other biological processes","other membranes;other cell component","enzyme regulator activity","PPP2R1B","ENSG00000137713","mRNA surveillance pathway; Sphingolipid signaling pathway; Oocyte meiosis; PI3K-Akt signaling pathway; AMPK signaling pathway; Adrenergic signaling in cardiomyocytes; TGF-beta signaling pathway; Hippo signaling pathway; Tight junction; Dopaminergic synapse; Long-term depression; Chagas disease; Hepatitis C; Human papillomavirus infection","Regulation of TP53 Degradation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; DARPP-32 events; Cyclin A/B1/B2 associated events during G2/M transition; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Cyclin D associated events in G1; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; S33 mutants of beta-catenin aren't phosphorylated; S37 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; T41 mutants of beta-catenin aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; MASTL Facilitates Mitotic Progression; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Netrin-UNC5B signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome",1183.1,1199.5,1250,1388.8,1393.9,1137.8,0.9265654890957786,-0.11003514620663953,0.3313772387192625,{"$f":"-LOG10(AA1603)","v":0.4796773252410817},0.547724160515398,{"$f":"-LOG10(AC1603)","v":0.26143810159980385},4422]
["P30414","NK-tumor recognition protein [OS=Homo sapiens]",8,12,20,12,1462,165.6,9.99,53.52,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","NKTR","ENSG00000114857","","","",2095.4,2185.8,2204.6,2093.4,2149.7,2438.8,0.9706520600428024,-0.042973855070227905,0.5913522486152898,0.22815374744628644,0.7179723563337463,0.14389227682013803,6020]
["P30479","HLA class I histocompatibility antigen, B-41 alpha chain [OS=Homo sapiens]",40,12,106,2,362,40.5,6.54,299.71,"other biological processes","plasma membrane;other membranes","","HLA-B","","","","",3444.7,3631.3,3596,2762.2,2901.7,4118.5,1.0909388289172393,0.12557020918497752,0.5324355544680514,0.2737329513308815,0.6750340793767541,0.17067430107762638,5765]
["P30622-2","Isoform 3 of CAP-Gly domain-containing linker protein 1 [OS=Homo sapiens]",28,35,54,1,1392,156.7,5.36,147.85,"","","","CLIP1","","","","",329.9,308.1,319,371.3,389,479.7,0.7717741935483872,-0.3737492907882119,0.05076691395153935,1.2944192359365922,0.2364916342076489,0.6261842176395559,1569]
["P31146","Coronin-1A [OS=Homo sapiens]",62,30,362,27,461,51,6.68,1038.25,"cell adhesion;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","CORO1A","ENSG00000102879","Phagosome; Tuberculosis","Prevention of phagosomal-lysosomal fusion","16p11.2 proximal deletion syndrome",42668.1,42684.7,41947.6,40321.8,39726.6,42214.9,1.0411987898249109,0.05824554002541357,0.10028886977500542,0.9987472630266294,0.3239113341517961,0.48957385509738505,2263]
["P31153","S-adenosylmethionine synthase isoform type-2 [OS=Homo sapiens]",59,18,128,14,395,43.6,6.48,410.75,"cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;other cell component","other molecular function","MAT2A","ENSG00000168906","Cysteine and methionine metabolism; Metabolic pathways; Biosynthesis of amino acids; Biosynthesis of cofactors","Methylation","Trans-sulfuration and one-carbon metabolism; Methionine de novo and salvage pathway; One-carbon metabolism and related pathways; Methylation pathways",13670,13842.9,14140.3,14292,13405.7,13677.3,1.0067238670694865,0.009668022729566027,0.7696886565238296,0.11368491391526153,0.8436794226953614,0.0738225431872563,6668]
["P31641","Sodium- and chloride-dependent taurine transporter [OS=Homo sapiens]",1,1,1,1,620,69.8,7.39,0,"transport;other biological processes","plasma membrane;other membranes;other cell component","transporter activity","SLC6A6","ENSG00000131389","","Na+/Cl- dependent neurotransmitter transporters; Amino acid transport across the plasma membrane","Nuclear receptors meta-pathway; NRF2 pathway",79.9,69.4,68.2,74.7,69.1,114.8,0.8410672853828306,-0.24970687418680138,0.4088260585840139,0.38846143004907835,0.591822076092406,0.22780883886059158,5049]
["P31943","Heterogeneous nuclear ribonucleoprotein H [OS=Homo sapiens]",56,20,433,8,449,49.2,6.3,1435.7,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","HNRNPH1","ENSG00000169045; ENSG00000284254","","mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA","MECP2 and associated Rett syndrome; mRNA processing; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells",31513,32367.7,30453.7,32126.9,33206.3,36018.8,0.930760123135212,-0.10351869268240128,0.14289442126576415,0.8449847261480675,0.3784113496490834,0.42203584632931224,2760]
["P31947-1","14-3-3 protein sigma [OS=Homo sapiens]",62,15,140,11,248,27.8,4.74,392.51,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;nucleus","enzyme regulator activity;other molecular function","SFN","ENSG00000175793; ENSGGOG00000011493; ENSNLEG00000018582; ENSPPAG00000013397; ENSPTRG00000030723","Cell cycle; p53 signaling pathway; Aldosterone-regulated sodium reabsorption","TP53 Regulates Metabolic Genes; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; Activation of BAD and translocation to mitochondria ; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest","miRNA regulation of DNA damage response; Cell cycle; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells; DNA damage response; Calcium regulation in cardiac cells",2052,2039.3,2177.1,2237,2133,2660.6,0.8915882001536142,-0.16555057170884688,0.20333039469546382,0.6917976963159449,0.4440220659782328,0.3525954467897491,3347]
["P32246","C-C chemokine receptor type 1 [OS=Homo sapiens]",3,1,1,1,355,41.1,8.16,1.86,"cell adhesion;cell-cell signaling;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","CCR1","ENSG00000163823","Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor; Chemokine signaling pathway; Human cytomegalovirus infection; Kaposi sarcoma-associated herpesvirus infection","G alpha (i) signalling events; Chemokine receptors bind chemokines; Interleukin-10 signaling","Peptide GPCRs; Chemokine signaling pathway; Selective expression of chemokine receptors during T-cell polarization; GPCRs, class A rhodopsin-like; CCL18 signaling pathway",121.3,124.9,119.2,258.2,272.4,240.4,0.47392996108949426,-1.0772542261749078,1.3610915699884714E-4,3.8661126558378656,0.019896436570091477,1.7012246982899115,50]
["P32455","Guanylate-binding protein 1 [OS=Homo sapiens]",35,18,53,16,592,67.9,6.32,161.45,"stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","GBP1","ENSG00000117228","NOD-like receptor signaling pathway","Interferon gamma signaling","Type II interferon signaling (IFNG)",5790.6,5957.7,5762,5838.2,5614.4,7399.3,0.9288347593611255,-0.10650613235271224,0.472723356482088,0.32539293939225367,0.6359534350317654,0.19657468254200153,5433]
["P33121","Long-chain-fatty-acid--CoA ligase 1 [OS=Homo sapiens]",8,7,12,6,698,77.9,7.15,31.55,"other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle","other molecular function","ACSL1","ENSG00000151726","Fatty acid biosynthesis; Fatty acid degradation; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; Peroxisome; Ferroptosis; Thermogenesis; Adipocytokine signaling pathway","PPARA activates gene expression; Synthesis of very long-chain fatty acyl-CoAs; alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism","Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters",947.5,947,1026.6,954.5,881.7,1926.4,0.7763514590974325,-0.36521817764548625,0.45300673824475807,0.3438953380296586,0.6194623479571444,0.20798508569048246,5345]
["P33981","Dual specificity protein kinase TTK [OS=Homo sapiens]",6,5,6,5,857,97,8.16,15.62,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","TTK","ENSG00000112742","Cell cycle","","Cell cycle; Retinoblastoma gene in cancer",566.5,535.7,577.1,596.3,551.9,437.3,1.0591611479028702,0.0829221073598377,0.5578616571670243,0.25347348740309644,0.6930836056831176,0.15921437390656998,5883]
["P33993-1","DNA replication licensing factor MCM7 [OS=Homo sapiens]",68,42,230,42,719,81.3,6.46,689.22,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","MCM7","ENSG00000166508","DNA replication; Cell cycle","Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Assembly of the pre-replicative complex; Unwinding of DNA","miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication",25227.6,25465.5,26377,24061.8,23234.6,20324.3,1.1397412330839523,0.18870631200158114,0.05667660861594493,1.2465961447239127,0.24894791609010908,0.6038915047946448,1664]
["P34932","Heat shock 70 kDa protein 4 [OS=Homo sapiens]",77,56,447,51,840,94.3,5.19,1386.98,"cell organization and biogenesis;stress response;transport","non-structural extracellular;cytosol;mitochondrion;nucleus","other molecular function","HSPA4","ENSG00000170606","Tight junction; Antigen processing and presentation; Lipid and atherosclerosis","Regulation of HSF1-mediated heat shock response","Parkin-ubiquitin proteasomal system pathway",51930.8,51215.4,53464.6,50395.3,50025.7,42113.3,1.0987586847516706,0.13587456868940662,0.16689006351745045,0.7775695200493604,0.407006831581263,0.3903983011110323,2997]
["P35236","Tyrosine-protein phosphatase non-receptor type 7 [OS=Homo sapiens]",31,8,27,8,360,40.5,6.79,80.38,"protein metabolism;other metabolic processes;signal transduction","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","PTPN7","ENSG00000143851","MAPK signaling pathway","Interleukin-37 signaling; Negative regulation of MAPK pathway","MAPK signaling pathway; IL-18 signaling pathway",2980.9,3015.1,3032.9,3030.4,2828.2,2957.7,1.0241144244184068,0.034376916820794724,0.31041494089926,0.5080573834385191,0.5364915590051292,0.2704371067014465,4229]
["P35241-1","radixin [OS=Homo sapiens]",55,38,230,19,583,68.5,6.37,622.21,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","RDX","ENSG00000137710; ENSPPAG00000040677; ENSRBIG00000033138; ENSRROG00000036137","Tight junction; Regulation of actin cytoskeleton; Proteoglycans in cancer; MicroRNAs in cancer","Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea","Regulation of actin cytoskeleton",8837.7,8702.8,8550,9634.7,9424,10184.9,0.8921781176052197,-0.16459633122956452,0.012148866447711232,1.915464242104361,0.11902957756879544,0.924345107693057,746]
["P35556","Fibrillin-2 [OS=Homo sapiens]",0,1,1,1,2912,314.6,4.86,0,"developmental processes;other biological processes","non-structural extracellular;extracellular matrix","extracellular structural activity;other molecular function","FBN2","ENSG00000138829","","Degradation of the extracellular matrix; Molecules associated with elastic fibres","Hypothesized pathways in pathogenesis of cardiovascular disease",44.3,76.3,31.1,142.3,61.3,142.3,0.43856605955478456,-1.1891339281258948,0.09831365750353319,1.0073861468024998,0.3212224062106947,0.49319416901515645,2237]
["P35568","Insulin receptor substrate 1 [OS=Homo sapiens]",3,3,5,3,1242,131.5,8.54,11.72,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","IRS1","ENSG00000169047","cGMP-PKG signaling pathway; FoxO signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Neurotrophin signaling pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Regulation of lipolysis in adipocytes; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; Growth hormone synthesis, secretion and action; Aldosterone-regulated sodium reabsorption; Alzheimer disease; MicroRNAs in cancer; Diabetic cardiomyopathy","RAF/MAP kinase cascade; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by ALK fusions and activated point mutants; PI3K Cascade; Interleukin-7 signaling; PI3K/AKT activation; Signaling by ALK; Growth hormone receptor signaling; Signaling by Leptin; SOS-mediated signalling; IRS activation; Signal attenuation; Activated NTRK3 signals through PI3K","Type II diabetes mellitus; Integrated breast cancer pathway; Leptin signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; AGE/RAGE pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Transcription factor regulation in adipogenesis; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; PI3K-Akt signaling pathway; Nonalcoholic fatty liver disease; Gastrin signaling pathway; Insulin signaling; FOXA2 pathway; Neuroinflammation and glutamatergic signaling; Congenital generalized lipodystrophy (CGL); Alzheimer's disease; EPO receptor signaling; Interferon type I signaling pathways; DNA damage response (only ATM dependent)",337.5,343.1,336.1,538.4,529.7,623.2,0.6011352214273045,-0.734238542653737,1.6732437871810038E-3,2.7764407788737024,0.04891895536202383,1.3105228256617671,250]
["P35612-1","Beta-adducin [OS=Homo sapiens]",17,9,14,9,726,80.8,5.92,31.34,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ADD2","ENSG00000075340","","Miscellaneous transport and binding events","",888.4,837.4,908.5,951.9,917.1,1201.3,0.8579943328013548,-0.2209599763774402,0.1891940899315694,0.7230924342671873,0.43132239654081117,0.3651979904013404,3206]
["P35813","Protein phosphatase 1A [OS=Homo sapiens]",39,13,32,12,382,42.4,5.36,89.7,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus","other molecular function","PPM1A","ENSG00000100614","MAPK signaling pathway","Energy dependent regulation of mTOR by LKB1-AMPK; Downregulation of SMAD2/3:SMAD4 transcriptional activity","TGF-beta signaling pathway; MAPK signaling pathway",3272.9,3244,3335.4,3348.5,3301.5,4933.9,0.8505166653717661,-0.23358858996443366,0.3430704097678233,0.4646167387457452,0.5545116375482134,0.2560893348711131,4522]
["P35998","26S proteasome regulatory subunit 7 [OS=Homo sapiens]",67,25,125,25,433,48.6,5.95,394.41,"protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","PSMC2","ENSG00000161057","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection","Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of expression of SLITs and ROBOs; Downstream TCR signaling; Interleukin-1 signaling; Neutrophil degranulation; AUF1 (hnRNP D0) binds and destabilizes mRNA; MAPK6/MAPK4 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Orc1 removal from chromatin; SCF(Skp2)-mediated degradation of p27/p21; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease",11714,11626.5,11923,12173,11663.1,9645.7,1.0532139849112054,0.07479858318868651,0.4870581719590018,0.31241916557788524,0.6463159366100842,0.18955513527879836,5508]
["P36551","Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial [OS=Homo sapiens]",43,18,69,18,454,50.1,8.25,212.4,"other metabolic processes","cytosol;mitochondrion;other cell component","other molecular function","CPOX","ENSG00000080819","Porphyrin and chlorophyll metabolism; Metabolic pathways; Biosynthesis of cofactors","Heme biosynthesis","Heme biosynthesis",7066,7263.1,7183.2,7153.6,6752.8,8091.3,0.9779340567422957,-0.03219090907423487,0.7070385040379681,0.15055693466719558,0.8016978631730545,0.09598927395953827,6446]
["P36969","Phospholipid hydroperoxide glutathione peroxidase, mitochondrial [OS=Homo sapiens]",38,8,39,8,197,22.2,8.37,102.9,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","GPX4","ENSG00000167468","Glutathione metabolism; Metabolic pathways; Ferroptosis","Synthesis of 15-eicosatetraenoic acid derivatives; Synthesis of 12-eicosatetraenoic acid derivatives; Synthesis of 5-eicosatetraenoic acids","Glutathione metabolism; Selenium micronutrient network; Folate metabolism; One-carbon metabolism and related pathways; Ferroptosis; Metapathway biotransformation Phase I and II",3471.9,3383.2,3621.3,3059.1,2700.2,3102.3,1.1822244289970212,0.2415039372635498,0.020684417023297878,1.6843567149005785,0.15332901016560263,0.8143756679578166,986]
["P37235","Hippocalcin-like protein 1 [OS=Homo sapiens]",52,10,18,10,193,22.3,5.35,42.62,"","other membranes","other molecular function","HPCAL1","ENSG00000115756","","","",2044.6,2081.9,1995.9,2692.4,2662.7,3285.2,0.708586507412937,-0.4969841003227134,0.014743138823648272,1.8314100450611241,0.1315721632015204,0.8808359849375696,819]
["P38432","coilin [OS=Homo sapiens]",16,10,16,10,576,62.6,9.07,42.12,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","COIL","ENSG00000121058","","","Genotoxicity pathway",1422.9,1491.8,1502.3,1873.8,2051.8,2588.2,0.6780988056126991,-0.5604325914641647,0.031865754922758525,1.4966757883121664,0.18752560606315785,0.7269394222687547,1242]
["P38606","V-type proton ATPase catalytic subunit A [OS=Homo sapiens]",66,30,212,30,617,68.3,5.52,604.83,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ATP6V1A","ENSG00000114573","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis","Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Proximal tubule transport",20141.1,20244.7,20002.8,19573.5,18777,16701.5,1.096937440964906,0.13348125027779298,0.10709778560624708,0.9702195087099726,0.3335226736242266,0.47687463642459227,2347]
["P39210","Protein Mpv17 [OS=Homo sapiens]",16,2,3,2,176,19.7,9.47,5.65,"cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","transporter activity","MPV17","ENSG00000115204","Peroxisome","Peroxisomal protein import","",332.3,282.2,617.6,280,369.3,340.7,1.2445454545454546,0.3156189228458777,0.49542163141325885,0.30502503489527893,0.6519691580841752,0.1857729484255447,5554]
["P40306","Proteasome subunit beta type-10 [OS=Homo sapiens]",27,6,23,6,273,28.9,7.81,77.74,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PSMB10","ENSG00000205220","Proteasome","Regulation of PTEN stability and activity; FCERI mediated NF-kB activation; Downstream TCR signaling; Regulation of expression of SLITs and ROBOs; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; MAPK6/MAPK4 signaling; Degradation of beta-catenin by the destruction complex; ER-Phagosome pathway; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; CDT1 association with the CDC6:ORC:origin complex; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation",2706.4,2676,2632.5,2768.7,2808.6,3426.3,0.8901883690968059,-0.16781744374442648,0.19829280653710935,0.7026930403983515,0.4387896224582901,0.3577436522057927,3303]
["P40616","ADP-ribosylation factor-like protein 1 [OS=Homo sapiens]",64,9,33,9,181,20.4,5.72,97.08,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","ARL1","ENSG00000120805","","Retrograde transport at the Trans-Golgi-Network","",2256.6,2359.2,2408.9,2187.3,2186.1,1673.5,1.1617026906348706,0.21624089350263925,0.13910846391726142,0.8566464449847081,0.37518220028459914,0.42575777397514086,2710]
["P40937-1","Replication factor C subunit 5 [OS=Homo sapiens]",45,13,39,13,340,38.5,7.2,117.6,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RFC5","ENSG00000111445","DNA replication; Nucleotide excision repair; Mismatch repair","Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER","Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair",4411.7,4420.5,4658.7,4415,3909.8,4728.2,1.033547843407646,0.04760517332974822,0.5931531429617798,0.22683316404435705,0.7190838152110879,0.14322048602573667,6029]
["P41226","ubiquitin-like modifier-activating enzyme 7 [OS=Homo sapiens]",8,7,9,7,1012,111.6,6.04,25.58,"protein metabolism;other metabolic processes;stress response","cytosol;nucleus;other cell component","other molecular function","UBA7","ENSG00000182179","Ubiquitin mediated proteolysis; Parkinson disease; Pathways of neurodegeneration","Termination of translesion DNA synthesis; Antigen processing: Ubiquitination & Proteasome degradation; ISG15 antiviral mechanism; Negative regulators of DDX58/IFIH1 signaling","Proteasome degradation; Parkinson's disease pathway",1018.4,996.9,1130.5,1052.4,967.9,1962.7,0.7898066783831283,-0.34042852801403695,0.43387974110835587,0.3626306276542747,0.60798064182534,0.21611024849416546,5216]
["P41227-1","N-alpha-acetyltransferase 10 [OS=Homo sapiens]",47,12,58,12,235,26.4,5.64,151.74,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","translation activity;other molecular function","NAA10","ENSCATG00000038709; ENSCSAG00000006823; ENSG00000102030; ENSGGOG00000009788; ENSMFAG00000044161; ENSMMUG00000000322; ENSMNEG00000034261; ENSPPYG00000020861; ENSPTRG00000022419; ENSRROG00000041881","","","",5225,4773.8,4999.6,5753.6,5395,7997,{"$f":"AVERAGE(S1794:U1794)/AVERAGE(V1794:X1794)","v":0.7833862610730403},{"$f":"LOG(Y1794,2)","v":-0.35220426817593126},{"$f":"TTEST(V1794:X1794,S1794:U1794,2,2)","v":0.1689280652992529},0.7722981918022903,{"$f":"AA1794*7309/AE1794","v":0.4099253749243823},0.38729519744698027,3012]
["P41567","eukaryotic translation initiation factor 1 [OS=Homo sapiens]",39,4,6,4,113,12.7,7.44,21.11,"protein metabolism;other metabolic processes;other biological processes","translational apparatus;nucleus;other cell component","translation activity;nucleic acid binding activity","EIF1","ENSG00000173812","","","Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell",246.5,267.7,248.6,293.4,302.3,274.4,0.8766808412826111,-0.18987637479733294,0.028254084268388567,1.5489187638794604,0.17833255778726428,0.7487693613869049,1158]
["P42167-2","Isoform Gamma of Lamina-associated polypeptide 2, isoforms beta/gamma [OS=Homo sapiens]",54,18,162,2,345,38.7,9.16,512.19,"","","","TMPO","","","","",544.2,508.8,454.6,585.6,606.7,486.7,0.8979154258487193,-0.15534853016003608,0.2752604251775181,0.560256223632036,0.509465294409339,0.29288539548460724,3949]
["P42285","Superkiller viralicidic activity 2-like 2 [OS=Homo sapiens]",29,28,77,28,1042,117.7,6.52,226.12,"RNA metabolism OR transcription;other metabolic processes;stress response","nucleus","other molecular function","MTREX","ENSG00000039123","RNA degradation","Major pathway of rRNA processing in the nucleolus and cytosol; mRNA Splicing - Major Pathway","",7334.6,7321.6,7413.8,9534.3,9726.6,7600.9,0.8216128479848707,-0.28346935288664477,0.07843045064436022,1.1055152896208327,0.28864459403808096,0.5396365718962222,1986]
["P42574","Caspase-3 [OS=Homo sapiens]",50,10,57,9,277,31.6,6.54,162.65,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","CASP3","ENSG00000164305","Platinum drug resistance; MAPK signaling pathway; p53 signaling pathway; Apoptosis; Apoptosis; Natural killer cell mediated cytotoxicity; IL-17 signaling pathway; TNF signaling pathway; Serotonergic synapse; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Alcoholic liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Salmonella infection; Pertussis; Legionellosis; Toxoplasmosis; Amoebiasis; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Colorectal cancer; Small cell lung cancer; Viral myocarditis; Lipid and atherosclerosis","Caspase-mediated cleavage of cytoskeletal proteins; Degradation of the extracellular matrix; Other interleukin signaling; Apoptosis induced DNA fragmentation; Signaling by Hippo; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Caspase activation via Dependence Receptors in the absence of ligand; Pyroptosis; NADE modulates death signalling; Apoptotic cleavage of cell adhesion  proteins; Stimulation of the cell death response by PAK-2p34","miRNA regulation of DNA damage response; Integrated breast cancer pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; AGE/RAGE pathway; Allograft Rejection; Corticotropin-releasing hormone signaling pathway; Parkinson's disease pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Copper homeostasis; Hepatitis C and hepatocellular carcinoma; MAPK signaling pathway; Apoptosis modulation by HSP70; ERK pathway in Huntington's disease; Oxidative damage response; miRNA regulation of p53 pathway in prostate cancer; Prion disease pathway; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; MTHFR deficiency; Acute viral myocarditis; Nonalcoholic fatty liver disease; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; Peroxiredoxin 2 induced ovarian failure; Complement system in neuronal development and plasticity; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; Sudden infant death syndrome (SIDS) susceptibility pathways; DNA damage response",6314.1,6598.8,6331.4,7027.1,6930.9,6633.7,0.9345658687723695,-0.09763174530715578,0.04019990393500357,1.3957749847400998,0.20779427005724266,0.6823664323170072,1414]
["P42680","Tyrosine-protein kinase Tec [OS=Homo sapiens]",8,5,9,5,631,73.5,8.44,26.54,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton","kinase activity;other molecular function","TEC","ENSG00000135605","Osteoclast differentiation; T cell receptor signaling pathway","FCERI mediated Ca+2 mobilization; Interleukin-3, Interleukin-5 and GM-CSF signaling; Signaling by SCF-KIT","Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; Kit receptor signaling pathway",960.7,947,1056.3,893.9,946.5,1255.9,0.9572715822110259,-0.06299981309704454,0.7276640359880899,0.1380690890855412,0.8160958169459797,0.08825884819716767,6517]
["P42766","60S ribosomal protein L35 [OS=Homo sapiens]",28,4,12,4,123,14.5,11.05,22.64,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;translational apparatus;nucleus","nucleic acid binding activity;other molecular function","RPL35","ENSG00000136942","Ribosome; Coronavirus disease","Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",2833.7,2340.7,2270.3,2417.4,2643.8,2010.2,1.0527901122832817,0.07421784457820975,0.652919711581072,0.1851402198904585,0.761722294005755,0.11820333333665438,6265]
["P43243","Matrin-3 [OS=Homo sapiens]",46,44,247,44,847,94.6,6.25,724.57,"stress response;developmental processes;other biological processes","other membranes;nucleus","nucleic acid binding activity;other molecular function","MATR3","ENSG00000015479","Amyotrophic lateral sclerosis","","",31192.8,31701.4,31747.2,34868.3,35524.9,29746.6,0.9450927603210708,-0.08147215890014067,0.3744505834964142,0.426605488327378,0.571608044021573,0.24290166817777809,4788]
["P43246-1","DNA mismatch repair protein MSH2 [OS=Homo sapiens]",46,34,131,34,934,104.7,5.77,390.5,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MSH2","ENSG00000095002","Platinum drug resistance; Mismatch repair; Pathways in cancer; Colorectal cancer","TP53 Regulates Transcription of DNA Repair Genes; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MSH3; Defective Mismatch Repair Associated With MSH2; Defective Mismatch Repair Associated With MSH6","RAC1/PAK1/p38/MMP2 pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ciliary landscape; DNA repair pathways, full network; p53 transcriptional gene network; DNA mismatch repair",15640.3,15534.9,15859.4,15945.3,15454.3,16052.4,0.991203742729495,-0.01274645986336012,0.5391705972771579,0.2682737993148294,0.6790966561259257,0.16806840799538683,5803]
["P43490","nicotinamide phosphoribosyltransferase [OS=Homo sapiens]",64,26,133,26,491,55.5,7.15,417.93,"cell-cell signaling;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","NAMPT","ENSG00000105835","Nicotinate and nicotinamide metabolism; Metabolic pathways; NOD-like receptor signaling pathway","BMAL1:CLOCK,NPAS2 activates circadian gene expression; Nicotinamide salvaging","Adipogenesis; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; Caloric restriction and aging; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence",15224.3,15547,15326.1,15764.1,14495.6,14702.5,1.0252478748815672,0.03597275327156489,0.4022874610644371,0.39546350378317585,0.5881814468733688,0.23048867865179312,4999]
["P45880","Voltage-dependent anion-selective channel protein 2 [OS=Homo sapiens]",65,14,219,13,294,31.5,7.56,684.41,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","transporter activity;other molecular function","VDAC2","ENSG00000165637","Calcium signaling pathway; cGMP-PKG signaling pathway; Ferroptosis; Necroptosis; Cellular senescence; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Cholesterol metabolism; Alzheimer disease; Parkinson disease; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Human T-cell leukemia virus 1 infection; Chemical carcinogenesis; Diabetic cardiomyopathy","Ub-specific processing proteases; Mitochondrial calcium ion transport","Alzheimer's disease and miRNA effects; Ferroptosis; Alzheimer's disease",19245.5,19627.3,20444.3,16009.5,15971.1,11325.8,1.3697074797258606,0.453867818288327,0.028650670799583354,1.542865205419206,0.1791340914235712,0.746821754697073,1169]
["P46013","Proliferation marker protein Ki-67 [OS=Homo sapiens]",54,140,476,13,3256,358.5,9.45,1457.52,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MKI67","ENSG00000148773","","","Primary focal segmental glomerulosclerosis (FSGS)",55498.7,55059.3,54979.6,58365.7,60126.3,61058.2,0.9219572019412955,-0.1172283138424545,4.4034549502735415E-3,2.3562064423655453,0.07519825287745167,1.1237922494947445,428]
["P46108-1","Adapter molecule crk [OS=Homo sapiens]",21,4,6,4,304,33.8,5.55,20.67,"cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","Crk; CRK","ENSANAG00000030093; ENSBTAG00000005665; ENSCANG00000032179; ENSCATG00000041862; ENSCCAG00000032085; ENSG00000167193; ENSGGOG00000006758; ENSLAFG00000010559; ENSMFAG00000000502; ENSMMUG00000040390; ENSMNEG00000039514; ENSPPAG00000029995; ENSPTRG00000045379; ENSRBIG00000006454; ENSRROG00000035466","MAPK signaling pathway; ErbB signaling pathway; Rap1 signaling pathway; Chemokine signaling pathway; Focal adhesion; Fc gamma R-mediated phagocytosis; Neurotrophin signaling pathway; Regulation of actin cytoskeleton; Insulin signaling pathway; Growth hormone synthesis, secretion and action; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection; Human cytomegalovirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; MicroRNAs in cancer; Renal cell carcinoma; Chronic myeloid leukemia","Regulation of signaling by CBL; ARMS-mediated activation; FCGR3A-mediated phagocytosis; Regulation of signaling by CBL; Regulation of actin dynamics for phagocytic cup formation; Downstream signal transduction; VEGFA-VEGFR2 Pathway; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; ARMS-mediated activation; p130Cas linkage to MAPK signaling for integrins; MET activates RAP1 and RAC1; MET receptor recycling","Kit receptor signaling pathway; TCR signaling pathway; B cell receptor signaling pathway; ErbB signaling pathway; Hepatocyte growth factor receptor signaling; Actin cytoskeleton regulation; Integrin-mediated cell adhesion; Integrin-mediated cell adhesion; B cell receptor signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; Focal adhesion; Interferon type I signaling pathways; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Rett syndrome causing genes; EGF/EGFR signaling pathway; Gastrin signaling pathway; Insulin signaling; Regulation of actin cytoskeleton; Interferon type I signaling pathways; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; EGFR1 signaling pathway; MAPK signaling pathway; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; Integrin-mediated cell adhesion; Insulin signaling; EGF/EGFR signaling pathway; MAPK signaling pathway",468.8,455.5,452,492.2,510.6,363.9,1.0070242189214897,0.010098380561942939,0.9483526087023638,0.02303015681669192,0.9656602419901891,0.01517564892994,7178]
["P46736","Lys-63-specific deubiquitinase BRCC36 [OS=Homo sapiens]",27,8,28,1,316,36,5.92,93.21,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","BRCC3","ENSG00000185515","Homologous recombination; NOD-like receptor signaling pathway","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs","",2023.5,1889.2,1972.2,1942.2,1926.3,1714.7,1.054037111334002,0.07592566336504215,0.2928952600585387,0.5332876564750342,0.5234160038552224,0.281153002598403,4090]
["P46777","60S ribosomal protein L5 [OS=Homo sapiens]",64,20,365,20,297,34.3,9.72,1037.11,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;ER/Golgi;translational apparatus;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","RPL5","ENSG00000122406","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; SRP-dependent cotranslational protein targeting to membrane; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","VEGFA-VEGFR2 signaling pathway; Cytoplasmic ribosomal proteins",46795.7,46652.3,45862.9,46480.4,47979.2,46094.6,0.99115430204149,-0.012818422479402972,0.5548065990738916,0.2558583819096171,0.6918753510716728,0.15997214140726299,5861]
["P46940","Ras GTPase-activating-like protein IQGAP1 [OS=Homo sapiens]",63,84,618,82,1657,189.1,6.48,2180.23,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","IQGAP1","ENSG00000140575","Adherens junction; Regulation of actin cytoskeleton; Proteoglycans in cancer","Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; RHOV GTPase cycle; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHO GTPases activate IQGAPs; RAC2 GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants","VEGFA-VEGFR2 signaling pathway; Ebola virus pathway in host; Ciliary landscape; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway",63103.8,63620.7,63478.5,56989,56244.8,43318.6,1.2149478385511816,0.28089437582370186,0.06494370028591613,1.1874629702838901,0.26356108017199387,0.5791187212194505,1801]
["P46976-2","Isoform GN-1 of Glycogenin-1 [OS=Homo sapiens]",39,10,56,10,333,37.5,5.4,196.35,"","","","GYG1","","","","",5199,5299,5167.9,4948.4,5270.3,4639,1.0543960370716867,0.07641685312574088,0.22208972926074164,0.6534715253260145,0.46378680890478874,0.3336816077923172,3500]
["P47985","cytochrome b-c1 complex subunit Rieske, mitochondrial [OS=Homo sapiens]",37,10,82,10,274,29.6,8.32,229.58,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity;other molecular function","UQCRFS1","ENSG00000169021","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly",7559.8,7259.7,7700.2,7146.1,6960.7,5919.7,1.1244950440666117,0.16927730280867956,0.1082931012869598,0.9653992088265227,0.3353874056383005,0.4744532499126564,2360]
["P48163","NADP-dependent malic enzyme [OS=Homo sapiens]",31,13,54,13,572,64.1,6.13,156.68,"other metabolic processes;other biological processes","cytosol;mitochondrion","other molecular function","ME1","ENSG00000065833","Pyruvate metabolism; Metabolic pathways; Carbon metabolism; PPAR signaling pathway","PPARA activates gene expression; Pyruvate metabolism","Nuclear receptors meta-pathway; NRF2 pathway; PPAR signaling pathway; Clear cell renal cell carcinoma pathways; TCA cycle in senescence",5179,5277.6,5395.8,5523.8,5140.7,4519.9,1.0439925186375494,0.06211137343731893,0.49800583406141385,0.302765569517716,0.6537220979085621,0.18460683423624874,5568]
["P48431","Transcription factor SOX-2 [OS=Homo sapiens]",3,1,1,1,317,34.3,9.74,1.83,"cell organization and biogenesis;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SOX2","ENSG00000181449","Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells","Interleukin-4 and Interleukin-13 signaling; POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation; Transcriptional Regulation by MECP2; Deactivation of the beta-catenin transactivating complex; POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation","Cell differentiation - expanded index; Cardiac progenitor differentiation; Endoderm differentiation; Dopaminergic neurogenesis; Mesodermal commitment pathway; Ectoderm differentiation; let-7 inhibition of ES cell reprogramming; Pre-implantation embryo; Wnt signaling pathway and pluripotency; Sudden infant death syndrome (SIDS) susceptibility pathways",169.6,184.6,163,308.6,311.1,659.5,0.4043151969981238,-1.306447663670078,0.09516789398296618,1.0215095412979416,0.31674960706807825,0.4992839151920229,2196]
["P48553","Trafficking protein particle complex subunit 10 [OS=Homo sapiens]",3,4,7,4,1259,142.1,6.04,17.74,"transport","cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","TRAPPC10","ENSG00000160218","","COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs","",592.8,620.2,609.1,785.4,660.6,932,0.7662321278385198,-0.3841465761713018,0.07846977581577516,1.1052975881466112,0.2886439815991448,0.5396374933724534,1987]
["P48723","Heat shock 70 kDa protein 13 [OS=Homo sapiens]",22,9,30,9,471,51.9,5.76,85.01,"stress response;other biological processes","mitochondrion;ER/Golgi;other cell component","other molecular function","HSPA13","ENSG00000155304","","Regulation of HSF1-mediated heat shock response","",3024.1,3086.2,2983.5,3625.2,3624.9,6151.5,0.6785607688634193,-0.5594500721510147,0.1635846535780412,0.7862574413675721,0.40297951904344564,0.39471702580044093,2967]
["P48729-3","Isoform 3 of Casein kinase I isoform alpha [OS=Homo sapiens]",24,8,14,1,325,37.5,9.48,22.4,"","","","CSNK1A1","","","","",65.1,61.3,58.7,71.2,71.7,78.4,0.8364211477632173,-0.2576985559304376,0.015371426959409996,1.8132858142288275,0.13422910352010475,0.8721533103381145,837]
["P49116-1","Nuclear receptor subfamily 2 group C member 2 [OS=Homo sapiens]",8,4,8,4,596,65.4,6.28,19.2,"developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NR2C2","ENSCANG00000032916; ENSG00000177463; ENSMLEG00000044042; ENSMMUG00000005156; ENSPPAG00000023138","","Nuclear Receptor transcription pathway","Androgen receptor signaling pathway; Nuclear receptors; Hypothesized pathways in pathogenesis of cardiovascular disease; Epithelial to mesenchymal transition in colorectal cancer; Androgen receptor signaling pathway; Nuclear receptors",710.5,735.6,756,819.6,786.9,727.9,0.9433259081562714,-0.0841718034678337,0.214065627831852,0.6694530610630918,0.4554892791333352,0.3415218405746881,3435]
["P49137","MAP kinase-activated protein kinase 2 [OS=Homo sapiens]",17,7,14,5,400,45.5,8.68,31.3,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","MAPKAPK2","ENSG00000162889","MAPK signaling pathway; Cellular senescence; VEGF signaling pathway; C-type lectin receptor signaling pathway; Neurotrophin signaling pathway; Kaposi sarcoma-associated herpesvirus infection; Viral carcinogenesis","VEGFA-VEGFR2 Pathway; Oxidative Stress Induced Senescence; activated TAK1 mediates p38 MAPK activation; Regulation of HSF1-mediated heat shock response; p38MAPK events; CREB phosphorylation; Synthesis of Leukotrienes (LT) and Eoxins (EX); Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA","IL-1 signaling pathway; Microtubule cytoskeleton regulation; Interleukin-1 (IL-1) structural pathway; Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; VEGFA-VEGFR2 signaling pathway; p38 MAPK signaling pathway; Malignant pleural mesothelioma; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling",1310.6,1226.9,1317.9,1280.7,1331.5,1593.3,0.9167518725478542,-0.12539678711350377,0.31287098747159003,0.5046347071164293,0.5374322085616573,0.26967630965306294,4255]
["P49356","protein farnesyltransferase subunit beta [OS=Homo sapiens]",5,2,6,2,437,48.7,5.82,28.73,"protein metabolism;other metabolic processes","cytosol;cytoskeleton;other cell component","other molecular function","FNTB","ENSG00000257365","Terpenoid backbone biosynthesis","RAS processing; Potential therapeutics for SARS; Inactivation, recovery and regulation of the phototransduction cascade","",494.7,467.5,484.7,482.9,463.5,440.3,1.0434124179707218,0.06130950853596104,0.24271918551699198,0.614895893899424,0.4801175986315817,0.31865237474629554,3695]
["P49406","39S ribosomal protein L19, mitochondrial [OS=Homo sapiens]",34,9,28,9,292,33.5,9.5,78.73,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus","other molecular function","MRPL19","ENSG00000115364","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Cytoplasmic ribosomal proteins",3424.2,3393.5,3530.3,3326.3,3109,2288.6,1.1861667373537066,0.24630682122085318,0.16458914285885318,0.7835988164627837,0.4042278377538165,0.39337378145265184,2976]
["P49454","Centromere protein F [OS=Homo sapiens]",19,55,69,54,3210,367.5,5.07,183.38,"","","","","","","","",5225.4,5060.5,5301,5651.7,5906.9,7448.6,0.8200524011953366,-0.2862119942673506,0.1141257983971789,0.9426161712252126,0.34284646957870146,0.4649003182720581,2433]
["P49642","DNA primase small subunit [OS=Homo sapiens]",20,5,8,5,420,49.9,8.21,27.68,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","PRIM1","ENSG00000198056","DNA replication","Activation of the pre-replicative complex; Removal of the Flap Intermediate; Polymerase switching on the C-strand of the telomere; Polymerase switching; Defective pyroptosis; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Telomere C-strand synthesis initiation; DNA replication initiation","Retinoblastoma gene in cancer; Pyrimidine metabolism; G1 to S cell cycle control; DNA replication",445.6,432.5,475.9,471.3,484.7,421.6,0.9828687572590011,-0.02492930893448492,0.750571857727257,0.12460772324679308,0.8308238237359565,0.08049105863583055,6603]
["P49736","DNA replication licensing factor mcm2 [OS=Homo sapiens]",53,38,216,38,904,101.8,5.52,634.35,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MCM2","ENSG00000073111","DNA replication; Cell cycle","Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Assembly of the pre-replicative complex; Unwinding of DNA","Cell cycle; Ciliary landscape; G1 to S cell cycle control; DNA replication",21431.9,21434.6,22162.5,21544.8,21171.9,19868.8,1.0390425897372395,0.05525479066504528,0.22166388951998878,0.6543050505009173,0.46369243517504233,0.3337699892638564,3494]
["P49750-4","Isoform 4 of YLP motif-containing protein 1 [OS=Homo sapiens]",19,36,59,35,2146,241.5,6.55,155.29,"other biological processes","cytosol;nucleus","","YLPM1","ENSG00000119596","","","",7051.7,6515.5,6953.4,7504.5,7360.1,8231.2,0.8884992076481436,-0.1705576052092148,0.053151354864370705,1.2744856605363502,0.24159406262667008,0.6169137430648095,1608]
["P49770","Translation initiation factor eIF-2B subunit beta [OS=Homo sapiens]",27,8,18,8,351,39,6.16,55.22,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF2B2","ENSG00000119718","Herpes simplex virus 1 infection","Recycling of eIF2:GDP","Translation factors; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Rett syndrome causing genes",1246.6,1349.7,1229.2,1291.8,1320.8,2237.3,0.7887791500855689,-0.3423066776361736,0.3362187672670332,{"$f":"-LOG10(AA1987)","v":0.4733780485020407},0.550251448713557,{"$f":"-LOG10(AC1987)","v":0.2594388053534869},4466]
["P49773","Histidine triad nucleotide-binding protein 1 [OS=Homo sapiens]",48,4,23,4,126,13.8,6.95,82.96,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","HINT1","ENSG00000169567","","","",3433.7,3753.4,3298.8,3644.3,3872.2,3459.9,0.955313217448344,-0.065954269411113,0.4150063326453739,0.3819452762711398,0.594644439385422,0.22574263791835378,5101]
["P49840","Glycogen synthase kinase-3 alpha [OS=Homo sapiens]",35,10,22,7,483,50.9,8.75,54.73,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function","GSK3A","ENSG00000105723","Chemokine signaling pathway; Dopaminergic synapse; Non-alcoholic fatty liver disease; Shigellosis","XBP1(S) activates chaperone genes; Constitutive Signaling by AKT1 E17K in Cancer; AKT phosphorylates targets in the cytosol; Suppression of apoptosis; Maturation of nucleoprotein; Maturation of nucleoprotein","IL-5 signaling pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; Wnt signaling pathway; Regulation of apoptosis by parathyroid hormone-related protein; Angiopoietin-like protein 8 regulatory pathway; Nonalcoholic fatty liver disease; Insulin signaling; Glycogen synthesis and degradation",1516.3,1600,1698.8,1435.5,1391.3,1338.7,1.155947665346297,0.20907608239351613,0.022224179408523025,1.6531742656751665,0.15755240280979124,0.8025749690747102,1031]
["P49916-1","DNA ligase 3 [OS=Homo sapiens]",32,28,62,28,1009,112.8,9.01,209.66,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","LIG3","ENSG00000005156","Base excision repair","HDR through MMEJ (alt-NHEJ); Gap-filling DNA repair synthesis and ligation in TC-NER; Gap-filling DNA repair synthesis and ligation in GG-NER; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; Resolution of AP sites via the single-nucleotide replacement pathway","Base excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum",7592.3,7515.1,7498.8,7530.7,7751.9,9904.9,0.8975166253101737,-0.15598943168382717,0.31960057316425966,0.4953924505036908,0.5408568162207857,0.2669176926672164,4319]
["P50336","protoporphyrinogen oxidase [OS=Homo sapiens]",31,11,24,11,477,50.7,8.16,62.92,"other metabolic processes;other biological processes","other membranes;mitochondrion","other molecular function","PPOX","ENSG00000143224","Porphyrin and chlorophyll metabolism; Metabolic pathways; Biosynthesis of cofactors","Heme biosynthesis","Orexin receptor pathway; Heme biosynthesis",1654.5,1672.5,1756.5,1556,1514.5,2134.4,0.9766758247036448,-0.034048308231392266,0.851378859122567,0.06987713813868456,0.8987186714799021,0.04637623545806786,6924]
["P50443","sulfate transporter [OS=Homo sapiens]",1,1,1,1,739,81.6,8.38,2.85,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes","transporter activity","SLC26A2","ENSG00000155850","Chemical carcinogenesis","Transport and synthesis of PAPS; Multifunctional anion exchangers; Defective SLC26A2 causes chondrodysplasias","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Proteoglycan biosynthesis",46.7,39.6,44.9,45.2,45.3,71.4,0.8103767757875233,-0.30333526568448194,0.3177633480123441,0.49789619735507273,0.54037513043793,0.2673046466265243,4298]
["P50570-1","Dynamin-2 [OS=Homo sapiens]",44,37,151,2,870,98,7.44,464.51,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","DNM2","ENSG00000079805; ENSGGOG00000005968; ENSPTRG00000034439","Phospholipase D signaling pathway; Endocytosis; Fc gamma R-mediated phagocytosis; Synaptic vesicle cycle; Endocrine and other factor-regulated calcium reabsorption; Bacterial invasion of epithelial cells; Salmonella infection","MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Recycling pathway of L1; Clathrin-mediated endocytosis; NGF-stimulated transcription; Toll Like Receptor 4 (TLR4) Cascade; NOSTRIN mediated eNOS trafficking; Retrograde neurotrophin signalling; Formation of annular gap junctions","Synaptic vesicle pathway; Fragile X syndrome; Intracellular trafficking proteins involved in CMT neuropathy",18317.9,18270.9,19065.5,16611.5,16131.8,18262,1.0911473905652942,0.12584599192316473,0.08951038710877049,1.0481265646587055,0.3062881176863312,0.5138698511312514,2136]
["P50579-2","Isoform 2 of Methionine aminopeptidase 2 [OS=Homo sapiens]",35,13,57,1,455,50.5,5.35,180.07,"","","","METAP2","","","","",72.3,78.7,84.1,83.8,88.2,93.6,0.8851656626506023,-0.17598060769390367,0.08360077134214754,1.0777897155263791,0.2963327050144308,0.5282204145899039,2062]
["P50897","Palmitoyl-protein thioesterase 1 [OS=Homo sapiens]",20,5,15,5,306,34.2,6.52,51.73,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PPT1","ENSG00000131238","Fatty acid elongation; Metabolic pathways; Fatty acid metabolism; Lysosome","Fatty acyl-CoA biosynthesis","",1340.9,1375.7,1394.8,1611.1,1493.8,1505.9,0.8916890778172988,-0.16538734896487173,0.014669535485743254,1.83358363797488,0.13139661135453118,0.881415834844768,816]
["P50914","60S ribosomal protein L14 [OS=Homo sapiens]",29,6,40,6,215,23.4,10.93,109.32,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","other molecular function","RPL14","ENSG00000188846","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",4922.4,4689.2,4402.6,5218,5207.7,6522.8,0.8268696344809274,-0.274268205047519,0.10157328425561613,0.9932205049071532,0.3254709051399817,0.48748782829982873,2281]
["P51151","Ras-related protein Rab-9A [OS=Homo sapiens]",47,7,8,7,201,22.8,5.47,21.06,"transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","RAB9A","ENSG00000123595","Salmonella infection; Measles","RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Retrograde transport at the Trans-Golgi-Network; RHOBTB3 ATPase cycle","Ebola virus pathway in host",753.7,795.1,766.5,673.1,749.6,1054.9,0.9344930577978688,-0.0977441484319521,0.6685255631069296,0.1748819815149073,0.773019038245301,0.11180980995869698,6321]
["P51532-4","Isoform 4 of Transcription activator BRG1 [OS=Homo sapiens]",22,35,82,18,1617,181.6,8.07,239.68,"","","","SMARCA4","","","","",3637.2,3578,3795.3,4220.1,4276.1,4964.5,0.8179738052255825,-0.28987345181355717,0.03011464064421529,1.5212223148664872,0.18296584245101374,0.737629980322359,1203]
["P51571","translocon-associated protein subunit delta [OS=Homo sapiens]",36,5,27,5,173,19,6.15,88.66,"","other membranes;ER/Golgi;other cell component","","SSR4","ENSG00000180879","Protein processing in endoplasmic reticulum","SRP-dependent cotranslational protein targeting to membrane","VEGFA-VEGFR2 signaling pathway",3566.4,4016.7,4100.4,4479.7,3627.5,4815.3,0.9041207196749855,-0.14541267838766694,0.34985895597413924,0.45610700418612776,0.5592998926541959,0.25235526402539893,4572]
["P51648","Fatty aldehyde dehydrogenase [OS=Homo sapiens]",14,7,18,7,485,54.8,7.88,52.73,"other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ALDH3A2","ENSG00000072210","Glycolysis / Gluconeogenesis; Ascorbate and aldarate metabolism; Fatty acid degradation; Valine, leucine and isoleucine degradation; Lysine degradation; Arginine and proline metabolism; Histidine metabolism; Tryptophan metabolism; beta-Alanine metabolism; Glycerolipid metabolism; Pyruvate metabolism; Pantothenate and CoA biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Alcoholic liver disease","RND2 GTPase cycle; RND1 GTPase cycle","Fragile X syndrome; Tryptophan metabolism; Fluoroacetic acid toxicity",1708.3,1668.7,1822,1589.3,1572.7,1107,1.2178496134926213,0.2843359926336874,0.1327909967346145,0.8768313692528272,0.3680581703197942,0.43408353716228865,2637]
["P51692","Signal transducer and activator of transcription 5B [OS=Homo sapiens]",10,8,12,8,787,89.8,6.05,26.85,"other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","STAT5B","ENSG00000173757","ErbB signaling pathway; Chemokine signaling pathway; Necroptosis; JAK-STAT signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; Prolactin signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Hepatitis B; Measles; Human T-cell leukemia virus 1 infection; Pathways in cancer; Viral carcinogenesis; Chemical carcinogenesis; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer","Interleukin-3, Interleukin-5 and GM-CSF signaling; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Growth hormone receptor signaling; Signaling by Leptin; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Signaling by cytosolic FGFR1 fusion mutants; Prolactin receptor signaling; Interleukin-20 family signaling; Erythropoietin activates STAT5; Signaling by FLT3 fusion proteins; Interleukin-2 signaling; STAT5 activation downstream of FLT3 ITD mutants; Interleukin-15 signaling; Interleukin-9 signaling; Interleukin-21 signaling; STAT5 Activation","IL-5 signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; AGE/RAGE pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Chemokine signaling pathway; IL-4 signaling pathway; White fat cell differentiation; Non-small cell lung cancer; EGF/EGFR signaling pathway; Hepatitis B infection; Endochondral ossification; Endochondral ossification with skeletal dysplasias; IL-2 signaling pathway; 3q29 copy number variation syndrome; FOXP3 in COVID-19; Familial partial lipodystrophy (FPLD); EPO receptor signaling; ErbB signaling pathway",1238.9,1261.6,1360.7,1425.5,1253.5,2078.6,0.8115856734487976,-0.3011846968046195,0.30481654646106265,0.5159614617363414,0.5319732898958709,0.2741101728591731,4188]
["P51795-2","Isoform 2 of H(+)/Cl(-) exchange transporter 5 [OS=Homo sapiens]",4,5,9,4,816,90.7,6.19,13.15,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","CLCN5","ENSG00000171365; ENSPPAG00000029912; ENSPTRG00000021899","Neutrophil extracellular trap formation","Stimuli-sensing channels","",748.9,753.1,762.8,820.8,782.3,1491.8,0.7317845487737893,-0.45050914059703007,0.29599850388282917,0.5287104840663103,0.5261315819259724,0.27890562816955655,4112]
["P51946","Cyclin-H [OS=Homo sapiens]",5,2,3,2,323,37.6,7.15,2.43,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","enzyme regulator activity","CCNH","ENSG00000134480","Basal transcription factors; Nucleotide excision repair; Cell cycle","RUNX1 regulates transcription of genes involved in differentiation of HSCs; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Formation of Incision Complex in GG-NER; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry","Cell cycle; Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum",263,274,278.5,285.1,349.3,195.6,0.9825301204819276,-0.02542645952240298,0.9192919516039793,0.0365465421124678,0.9464861070958565,0.023885756402655473,7099]
["P51948-1","CDK-activating kinase assembly factor MAT1 [OS=Homo sapiens]",20,4,5,4,309,35.8,6.09,14,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","nucleus","enzyme regulator activity;kinase activity;other molecular function","MNAT1","ENSCANG00000033478; ENSCATG00000030975; ENSCSAG00000014164; ENSG00000020426; ENSMFAG00000000901; ENSMMUG00000001642; ENSNLEG00000013781; ENSPPAG00000033622; ENSPTRG00000006412; ENSRROG00000035712","Basal transcription factors; Nucleotide excision repair","RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of Incision Complex in GG-NER; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry","Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; Eukaryotic transcription initiation; G1 to S cell cycle control",181.9,173.8,170.9,215.9,220.4,250.3,0.7669676667637635,-0.3827623359111938,0.009132971658642417,2.039387890048829,0.10663400934986808,0.9721042613752857,626]
["P52272","Heterogeneous nuclear ribonucleoprotein M [OS=Homo sapiens]",64,43,419,43,730,77.5,8.7,1152.55,"RNA metabolism OR transcription;other metabolic processes;stress response","nucleus;other cell component","nucleic acid binding activity;other molecular function","HNRNPM","ENSG00000099783","Spliceosome","mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA","mRNA processing",51900.2,52481.3,53330.4,52427.7,50947.1,50203.6,1.0269145921561886,0.03831619860203046,0.14983636963092845,0.8243827579790225,0.3873908827847386,0.4118506045845691,2827]
["P52429","Diacylglycerol kinase epsilon [OS=Homo sapiens]",8,6,11,6,567,63.9,7.74,27.76,"other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","DGKE","ENSG00000153933","Glycerolipid metabolism; Glycerophospholipid metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Phospholipase D signaling pathway; Choline metabolism in cancer","Effects of PIP2 hydrolysis","Ciliary landscape",1794.7,1895.8,1844.9,1676.9,1800.3,1397.8,1.1354666666666666,0.18328535418168834,0.14694756291122,0.8328376121976006,0.38344867451556836,0.4162927591371958,2801]
["P52565-1","rho GDP-dissociation inhibitor 1 [OS=Homo sapiens]",40,9,172,9,204,23.2,5.11,548.54,"signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","ARHGDIA; HEL-S-47e","ENSCATG00000044701; ENSG00000141522; ENSGGOG00000011564; ENSMLEG00000000660; ENSMMUG00000009949; ENSMNEG00000037888; ENSPPAG00000035710; ENSPPYG00000008748; ENSPTRG00000009773; ENSRBIG00000034513; ENSRROG00000034509","Neurotrophin signaling pathway; Vasopressin-regulated water reabsorption","CDC42 GTPase cycle; RAC1 GTPase cycle; RHOC GTPase cycle; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOH GTPase cycle; Axonal growth stimulation; Axonal growth inhibition (RHOA activation)","Ciliary landscape; Nephrotic syndrome",30163.1,31403.2,31715.8,28457.1,27496.4,17242,1.2744239741514165,0.3498453118566132,0.13806768767556804,0.8599079485478469,0.37389282297915033,0.42725287122039063,2699]
["P52739","Zinc finger protein 131 [OS=Homo sapiens]",10,5,6,5,623,71.4,5.19,18.71,"other biological processes","cytoskeleton;nucleus","nucleic acid binding activity;other molecular function","ZNF131","ENSG00000172262","","SUMOylation of transcription cofactors","",328.5,319.4,326.8,293.3,339.5,332.8,{"$f":"AVERAGE(S2114:U2114)/AVERAGE(V2114:X2114)","v":1.0094241922120963},{"$f":"LOG(Y2114,2)","v":0.013532568295618394},{"$f":"TTEST(V2114:X2114,S2114:U2114,2,2)","v":0.8464098451565752},0.07241929371117294,{"$f":"AA2114*7309/AE2114","v":0.8950245309967315},0.04816506129803687,6912]
["P52815","39S ribosomal protein L12, mitochondrial [OS=Homo sapiens]",39,5,53,5,198,21.3,8.87,149.17,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL12","ENSG00000262814","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",3585,2923.6,2921.2,3429.4,4231.8,3108.5,0.8755861351755387,-0.19167898512851106,0.3272106242574431,0.48517260359034253,0.5457741790729465,0.2629870149310561,4382]
["P52907","F-actin-capping protein subunit alpha-1 [OS=Homo sapiens]",69,14,178,11,286,32.9,5.69,709.15,"cell organization and biogenesis","non-structural extracellular;cytosol;cytoskeleton;other cell component","cytoskeletal activity","CAPZA1","ENSG00000116489","Endocytosis","MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Sensory processing of sound by inner hair cells of the cochlea; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Factors involved in megakaryocyte development and platelet production; Advanced glycosylation endproduct receptor signaling","",15576.6,16125,15986.4,15009.1,14704.6,16070,1.041593405513316,0.05879221972279817,0.22721645985693306,0.643560210962286,0.4692639460566046,0.328582811715828,3539]
["P53365","Arfaptin-2 [OS=Homo sapiens]",23,4,6,3,341,37.8,6.04,24.62,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","ARFIP2","ENSG00000132254","","Retrograde transport at the Trans-Golgi-Network","",507.3,497.7,470,423.4,474.8,216.9,1.3227513227513226,0.40354186044101426,0.20625224009917395,0.6856013258935426,0.44719597237759195,0.3495021165305416,3371]
["P53370","Nucleoside diphosphate-linked moiety X motif 6 [OS=Homo sapiens]",3,1,2,1,316,35.7,8,4.1,"other biological processes","mitochondrion;nucleus;other cell component","other molecular function","NUDT6","ENSG00000170917","","","",137,149.7,156.2,128.2,127.2,96.3,1.2593119135626953,0.3326356622600093,0.06288289953023189,1.2014674411902233,0.2587900409158023,0.5870524407488327,1776]
["P53621-1","coatomer subunit alpha [OS=Homo sapiens]",54,57,294,57,1224,138.3,7.66,894.15,"transport;signal transduction","non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","COPA","ENSG00000122218","","COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic","",33217.8,33664.6,34638.5,32776.4,32277.1,28380.5,1.0865520046235844,0.11975722653672985,0.13685304746783666,0.8637455271999359,0.3723972166576389,0.4289935736486595,2686]
["P53701","Cytochrome c-type heme lyase [OS=Homo sapiens]",65,16,41,16,268,30.6,6.68,118.25,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes","other membranes;mitochondrion","other molecular function","HCCS","ENSG00000004961","Porphyrin and chlorophyll metabolism; Metabolic pathways","","",3829.7,3595.1,3609.2,4182.2,4152.7,4524.2,0.8580693827717338,-0.22083378733309283,0.012609868319997258,1.8992894485734024,0.1219120734799735,0.9139532821906359,756]
["P53801","pituitary tumor-transforming gene 1 protein-interacting protein [OS=Homo sapiens]",8,2,6,2,180,20.3,8.79,13.57,"transport;other biological processes","other membranes;nucleus;other cell component","other molecular function","PTTG1IP","ENSG00000183255","","","",999.3,1032.7,983.3,781.5,865.6,472.3,1.4227139756534868,0.5086456496486856,0.06827057086721224,1.165766465634574,0.26899709027949015,0.5702524177016657,1855]
["P54105","Methylosome subunit pICln [OS=Homo sapiens]",35,5,13,5,237,26.2,4.11,50.27,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","","CLNS1A","ENSG00000074201","","snRNP Assembly","",543.1,557.2,568.1,615,667.2,974.6,0.7392768521800779,-0.43581335369634605,0.15597848960288507,0.8069352894076547,0.3939346166231814,0.40457585430670034,2894]
["P54274-1","telomeric repeat-binding factor 1 [OS=Homo sapiens]",3,1,1,1,439,50.2,6.37,2.11,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","TERF1","ENSG00000147601","","Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Meiotic synapsis; Inhibition of DNA recombination at telomere; Packaging Of Telomere Ends; DNA Damage/Telomere Stress Induced Senescence; Telomere Extension By Telomerase; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; Removal of the Flap Intermediate from the C-strand","",55.2,57.5,55.9,87.5,86.9,61.5,0.7147096227214921,-0.4845708822973805,0.05942501676243046,1.2260306870952802,0.2551923898452434,0.5931322809598764,1702]
["P54296","Myomesin-2 [OS=Homo sapiens]",6,7,9,7,1465,164.8,6.19,23.9,"cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYOM2","ENSG00000036448; ENSG00000274137","","","",319.1,298,336.9,390.1,376,386.4,0.8277657266811279,-0.2727055793111889,0.005294265980398565,2.276194243820905,0.08078453037731338,1.0926717953514955,479]
["P54802","alpha-N-acetylglucosaminidase [OS=Homo sapiens]",19,10,20,10,743,82.2,6.65,57.38,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;other cytoplasmic organelle","other molecular function","NAGLU","ENSG00000108784","Glycosaminoglycan degradation; Metabolic pathways; Lysosome","HS-GAG degradation; MPS IIIB - Sanfilippo syndrome B","Glycosaminoglycan degradation",1688.8,1767.4,1781.2,1615,1596.3,1945.3,1.015669239421324,0.022430653745990587,0.8291465125696138,{"$f":"-LOG10(AA2179)","v":0.0813687215867409},0.8840600817463614,{"$f":"-LOG10(AC2179)","v":0.05351821882829938},6855]
["P54852","Epithelial membrane protein 3 [OS=Homo sapiens]",10,1,3,1,163,18.4,7.96,10.84,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes","","EMP3","ENSG00000142227","","","",206.8,211.6,227,182.8,180.6,253.8,1.045690213869086,0.06445551591620689,0.7239440451193861,0.14029499987328262,0.8139220159633277,0.08941720402879007,6501]
["P55039","Developmentally-regulated GTP-binding protein 2 [OS=Homo sapiens]",35,11,41,10,364,40.7,8.88,108.5,"protein metabolism;other metabolic processes;signal transduction","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DRG2","ENSG00000108591","","","",4048.6,4052.6,4118.1,3781.7,3744.8,3507.2,1.1074526224204029,0.1472449806212209,0.011292402068001892,1.9472136671168718,0.11527397585897461,0.9382687275407544,716]
["P55145","Mesencephalic astrocyte-derived neurotrophic factor [OS=Homo sapiens]",25,6,18,6,182,20.7,8.69,39.71,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","MANF","ENSG00000145050","","Platelet degranulation","Orexin receptor pathway",1351.2,1446.3,1450.9,1561.8,1638.9,1445.8,0.914322608414936,-0.12922480111316423,0.110146773179824,0.958028221261499,0.33712846112702416,0.4722045818348575,2388]
["P55197-1","Isoform 1 of Protein AF-10 [OS=Homo sapiens]",3,3,3,2,1027,109,8.38,6.62,"","","","MLLT10","","","","",215,256.5,238.1,299.4,316.5,265,0.8055397888523101,-0.3119722436809061,0.04177501634762441,1.379083371484082,0.2123321241201577,0.6729842956469728,1438]
["P55209-3","Isoform 3 of Nucleosome assembly protein 1-like 1 [OS=Homo sapiens]",47,11,262,1,323,37.3,4.67,864.92,"","","","NAP1L1","","","","",21.9,20.1,26.8,12.9,18.7,41.5,0.9411764705882354,-0.08746284125033926,0.8805968235559427,0.05522288543862592,0.9181572301526941,0.03708294152131158,7010]
["P55769","NHP2-like protein 1 [OS=Homo sapiens]",38,5,20,5,128,14.2,8.46,56.04,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SNU13","ENSG00000100138","Ribosome biogenesis in eukaryotes; Spliceosome","mRNA Splicing - Major Pathway; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; mRNA Splicing - Minor Pathway","mRNA processing",2600.1,2296.9,2113.3,2783.5,3096.2,2835.1,0.8044131821728555,-0.3139913711511337,0.029730115673308705,1.5268034010479399,0.18229648947668903,0.7392216945681847,1192]
["P55795","heterogeneous nuclear ribonucleoprotein H2 [OS=Homo sapiens]",48,18,271,7,449,49.2,6.3,653.89,"other biological processes","cytosol;nucleus;other cell component","","HNRNPH2","ENSG00000126945","","mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA","mRNA processing",7046.8,7240.4,6862.5,6924.6,7277,5944.9,1.0497952497952499,0.0701079746442382,0.46370512327456603,0.3337581057484016,0.6282151521805011,0.20189159288335806,5395]
["P56181-2","Isoform 2 of NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [OS=Homo sapiens]",22,7,14,7,473,51,9.17,48.09,"","","","NDUFV3","","","","",2033.8,1700,1883,2229,1452.9,1493.4,1.085309064208838,0.11810593843734303,0.6147471883263572,0.21130344892050254,0.7355028972789891,0.13341561216853917,6109]
["P56270-2","Isoform 2 of Myc-associated zinc finger protein [OS=Homo sapiens]",10,5,11,4,493,51,9.1,40.42,"","","","MAZ","","","","",846.6,865.4,839.7,943.9,1055.7,1098.9,0.8235275133128933,-0.28011124498794454,0.017642430116002448,1.7534415941882664,0.14295844979807304,0.8447901698462352,902]
["P56937-1","3-keto-steroid reductase [OS=Homo sapiens]",21,6,13,6,341,38.2,8.1,39.26,"other metabolic processes","other membranes;ER/Golgi","other molecular function","HSD17B7","ENSG00000132196","Steroid biosynthesis; Steroid hormone biosynthesis; Metabolic pathways; Ovarian steroidogenesis","Cholesterol biosynthesis","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Steroid biosynthesis",1124.5,1208,1117.8,1161.9,1221.3,1879.9,0.8093406206750956,-0.3051810889737433,0.3075526148795855,0.5120805761578822,0.5349600338302929,0.2716786623438429,4202]
["P57678","Gem-associated protein 4 [OS=Homo sapiens]",10,10,21,10,1058,120,6.04,54.82,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","GEMIN4","ENSG00000179409","","snRNP Assembly","",2103.4,2083.1,2090.6,2318.4,2202.4,2392.4,0.9079876178904126,-0.13925547108251435,0.018893450954238552,1.7236887094418178,0.14721986463169465,0.8320335859369095,938]
["P57737","Coronin-7 [OS=Homo sapiens]",52,34,178,1,925,100.5,5.8,561.51,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cell component","cytoskeletal activity","CORO7","ENSG00000262246; ENSG00000282725","","","",318.1,285.5,303.8,305.9,301.9,474.4,0.8384771761227132,-0.25415658163170674,0.36912935160273586,0.432821420173385,0.5682321884718611,0.24547416857196566,4748]
["P58005-1","sestrin-3 [OS=Homo sapiens]",5,2,3,2,492,57.3,6.25,5.58,"stress response;signal transduction;other biological processes","nucleus;other cell component","other molecular function","SESN3","ENSG00000149212","p53 signaling pathway; Longevity regulating pathway","TP53 Regulates Metabolic Genes","Angiopoietin-like protein 8 regulatory pathway; miRNA regulation of p53 pathway in prostate cancer",122,135.8,143.2,97.3,104.8,164.7,1.093238822246456,0.12860859774722844,0.6348498687643285,0.19732896585147533,0.7502211302826962,0.12481070793264189,6185]
["P60468","protein transport protein Sec61 subunit beta [OS=Homo sapiens]",36,4,39,4,96,10,11.56,58.02,"protein metabolism;other metabolic processes;stress response;transport","other membranes;cytosol;ER/Golgi","translation activity;other molecular function","SEC61B","ENSG00000106803","Protein export; Protein processing in endoplasmic reticulum; Phagosome; Vibrio cholerae infection","ER-Phagosome pathway; SRP-dependent cotranslational protein targeting to membrane; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",4747,5015,4682,4022.2,4432.7,3268.9,1.232023746566813,0.3010300634386706,0.06335993380637542,1.1981852851360646,0.259729532356028,0.5854786664274463,1783]
["P60520","Gamma-aminobutyric acid receptor-associated protein-like 2 [OS=Homo sapiens]",35,5,6,5,117,13.7,8.1,15.85,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","GABARAPL2","ENSG00000034713","FoxO signaling pathway; Autophagy; Mitophagy; Autophagy; NOD-like receptor signaling pathway; GABAergic synapse","TBC/RABGAPs; Macroautophagy","Network map of SARS-CoV-2 signaling pathway; Senescence and autophagy in cancer",766.9,756.5,729.6,1131.2,1150,1962.8,0.5308671065032987,-0.9135773426793371,0.07283469107943236,1.1376617174478783,0.27726497765602665,0.5571049842674549,1920]
["P60891","ribose-phosphate pyrophosphokinase 1 [OS=Homo sapiens]",58,17,100,8,318,34.8,6.98,299.06,"other metabolic processes;developmental processes","cytosol;other cell component","kinase activity;other molecular function","PRPS1","ENSG00000147224","Pentose phosphate pathway; Purine metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids","5-Phosphoribose 1-diphosphate biosynthesis","Nucleotide metabolism",14004.7,13803.4,14559.9,12683.6,11950.9,10499,1.2059145829478988,0.27012772222829917,0.023946798948562158,1.6207525320150946,0.16388310254217306,0.7854658228236593,1068]
["P60953","Cell division control protein 42 homolog [OS=Homo sapiens]",48,8,143,2,191,21.2,6.55,517.75,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","CDC42","ENSG00000070831","MAPK signaling pathway; Ras signaling pathway; Rap1 signaling pathway; Chemokine signaling pathway; Endocytosis; Axon guidance; VEGF signaling pathway; Focal adhesion; Adherens junction; Tight junction; T cell receptor signaling pathway; Fc gamma R-mediated phagocytosis; Leukocyte transendothelial migration; Neurotrophin signaling pathway; Regulation of actin cytoskeleton; GnRH signaling pathway; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Bacterial invasion of epithelial cells; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Human papillomavirus infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; Renal cell carcinoma; Pancreatic cancer; Lipid and atherosclerosis","RHO GTPases Activate Formins; MAPK6/MAPK4 signaling; RHO GTPases activate IQGAPs; RAC1 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; GPVI-mediated activation cascade; CDC42 GTPase cycle; RHOG GTPase cycle; RAC3 GTPase cycle; RHOQ GTPase cycle; RAC2 GTPase cycle; RHOJ GTPase cycle; EPHB-mediated forward signaling; DCC mediated attractive signaling; Myogenesis; G beta:gamma signalling through CDC42; EGFR downregulation; RHO GTPases activate PAKs; Inactivation of CDC42 and RAC1; CD28 dependent Vav1 pathway; RHO GTPases activate KTN1","Androgen receptor signaling pathway; Target of rapamycin (TOR) signaling; Integrin-mediated cell adhesion; Integrated breast cancer pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; Microtubule cytoskeleton regulation; Metastatic brain tumor; Pathogenic Escherichia coli infection; RalA downstream regulated genes; B cell receptor signaling pathway; AGE/RAGE pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Focal adhesion; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; Oxidative damage response; p38 MAPK signaling pathway; Ebola virus pathway in host; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Hippo signaling regulation pathways; 22q11.2 copy number variation syndrome; Gastrin signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent)",13492.8,14212,13160.9,11551.8,12429.2,6408.7,1.34472206043495,0.4273080140691535,0.14044433225115266,0.8524957824269167,0.3768383349572962,0.42384492378369126,2724]
["P61020","Ras-related protein Rab-5B [OS=Homo sapiens]",66,9,33,6,215,23.7,8.13,109.45,"transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","RAB5B","ENSG00000111540","Ras signaling pathway; Endocytosis; Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection; Amoebiasis; Tuberculosis","RAB geranylgeranylation; Neutrophil degranulation; Clathrin-mediated endocytosis; RAB GEFs exchange GTP for GDP on RABs; TBC/RABGAPs","Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells",1250.4,1426.6,1369.7,1114.8,1176.2,1743.8,1.0029493407356,0.004248736842129381,0.9856180703446523,0.006291342741513792,0.9896802412624075,4.505100237535033E-3,7279]
["P61160-1","Actin-related protein 2 [OS=Homo sapiens]",36,11,110,11,394,44.7,6.74,332.6,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","Actr2; ACTR2; LOC111147990","ENSAMEG00000015749; ENSANAG00000038066; ENSBIXG00000015264; ENSBIXG00005008678; ENSBTAG00000009761; ENSCAFG00000003197; ENSCATG00000036025; ENSCCAG00000030047; ENSCHIG00000014272; ENSCJAG00000006722; ENSCPOG00000025808; ENSDLEG00000013424; ENSECAG00000009219; ENSFCAG00000004960; ENSG00000138071; ENSHGLG00000013085; ENSLAFG00000010273; ENSLCNG00005006073; ENSMFAG00000044097; ENSMLEG00000038155; ENSMLUG00000005227; ENSMMUG00000002263; ENSMNEG00000044163; ENSMPUG00000006176; ENSMUSG00000020152; ENSNLEG00000009948; ENSOANG00000039143; ENSOCUG00000004906; ENSPANG00000007073; ENSPCOG00000025808; ENSPCTG00005007920; ENSPPAG00000030634; ENSPPYG00000012359; ENSPTRG00000011990; ENSRBIG00000040326; ENSRFEG00010007536; ENSRROG00000043956; ENSSBOG00000028028; ENSSSUG00005000856; ENSSTOG00000012608; ENSTSYG00000034470; ENSVURG00010013014; ENSVVUG00000027598","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Salmonella infection; Yersinia infection; Pathogenic Escherichia coli infection; Shigellosis","Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; EPHB-mediated forward signaling; Regulation of actin dynamics for phagocytic cup formation; Neutrophil degranulation; EPHB-mediated forward signaling; Clathrin-mediated endocytosis; RHO GTPases Activate WASPs and WAVEs","ESC pluripotency pathways; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways",14416.3,14397,14434.9,13217.8,13253.1,13396.9,1.0847902317158207,0.11741609251149455,3.5639649650443035E-5,4.4480665738727385,0.013710010489215167,1.8629622129415944,19]
["P61201-1","COP9 signalosome complex subunit 2 [OS=Homo sapiens]",44,17,60,1,443,51.6,5.53,181.37,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","Cops2; COPS2; LOC101356833; LOC111162519","ENSACCG00020011181; ENSANAG00000033255; ENSBIXG00000019496; ENSBIXG00005014970; ENSCHIG00000021490; ENSCPOG00000003447; ENSCSAG00000010648; ENSDLEG00000002228; ENSG00000166200; ENSGALG00000000404; ENSLSDG00000017105; ENSMMUG00000009838; ENSMPUG00000012327; ENSMUSG00000027206; ENSOARG00000021006; ENSPPYG00000006460; ENSPSIG00000010252; ENSRNOG00000008744; ENSSHBG00005020299; ENSSSCG00000004652; ENSSSCG00070002171; ENSSTOG00000005348; ENSUMAG00000014609","","Cargo recognition for clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER; Formation of TC-NER Pre-Incision Complex; RHOBTB1 GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; Neddylation; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER; RHOBTB1 GTPase cycle; Neddylation; DNA Damage Recognition in GG-NER; Formation of TC-NER Pre-Incision Complex; Cargo recognition for clathrin-mediated endocytosis; RHOBTB1 GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; Neddylation; Formation of TC-NER Pre-Incision Complex; RHOBTB1 GTPase cycle; DNA Damage Recognition in GG-NER","Ciliary landscape",5474.9,5620.4,5262.2,5809.3,5670.5,4886.1,0.9994867376679559,-7.4067111667166358E-4,0.9931294576852181,2.9941361030474322E-3,0.9953082690554311,2.0423877820726372E-3,7293]
["P61313-1","60S ribosomal protein L15 [OS=Homo sapiens]",50,12,68,12,204,24.1,11.62,207.71,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;cytoskeleton;translational apparatus;nucleus","nucleic acid binding activity;other molecular function","LOC111155115; NR1D2; Rpl15; RPL15","ENSAMEG00000003497; ENSAMEG00000024645; ENSBIXG00000012476; ENSBIXG00005007092; ENSBMUG00000012295; ENSBTAG00000033080; ENSCAFG00000005764; ENSCAFG00030022972; ENSCAFG00040022162; ENSCANG00000040764; ENSCATG00000039291; ENSCGRG00001021972; ENSCGRG00015016653; ENSCJAG00000043224; ENSCPOG00000030042; ENSCSAG00000009762; ENSECAG00000010157; ENSFCAG00000026237; ENSG00000174748; ENSGGOG00000024274; ENSHGLG00000000795; ENSLCNG00005011910; ENSMFAG00000043886; ENSMLEG00000031741; ENSMLUG00000013809; ENSMMUG00000006353; ENSMPUG00000012148; ENSMUSG00000012405; ENSNLEG00000003580; ENSOANG00000045456; ENSOCUG00000010961; ENSOGAG00000013056; ENSPANG00000015926; ENSPPAG00000032386; ENSPPYG00000014065; ENSPTRG00000014695; ENSRBIG00000024014; ENSRBIG00000033415; ENSRFEG00010011144; ENSRNOG00000008140; ENSRROG00000001983; ENSRROG00000015533; ENSRROG00000027506; ENSRROG00000028991; ENSRROG00000037650; ENSSHAG00000031281; ENSSSCG00000037030; ENSSSCG00070018008; ENSSSUG00005002593; ENSSTOG00000011153; ENSUAMG00000015536; ENSVURG00010022414; ENSVVUG00000028235","Ribosome; Coronavirus disease","L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Formation of a pool of free 40S subunits; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins; Cytoplasmic ribosomal proteins; Cytoplasmic ribosomal proteins",12266.2,11557.6,10183.7,12974.8,14214.9,14247.5,0.8206997577056365,-0.28507356751533697,0.02878479963906099,1.5408367891705648,0.17935899451142095,0.7462768394021212,1173]
["P61626","lysozyme c [OS=Homo sapiens]",6,1,1,1,148,16.5,9.16,2.6,"other metabolic processes;stress response;other biological processes","non-structural extracellular;other cytoplasmic organelle;other cell component","other molecular function","LYZ","ENSG00000090382","Salivary secretion","Neutrophil degranulation; Amyloid fiber formation; Antimicrobial peptides","Macrophage markers",83.8,79.3,116.7,182,101.8,59.1,0.815981335666375,-0.2933919417708812,0.6085241963350445,0.2157221485335523,0.7302090545087573,0.13655278615100055,6091]
["P61769","Beta-2-microglobulin [OS=Homo sapiens]",8,1,2,1,119,13.7,6.52,6.3,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","B2M","ENSG00000166710; ENSG00000273686","Antigen processing and presentation; Human cytomegalovirus infection; Human T-cell leukemia virus 1 infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection","ER-Phagosome pathway; Neutrophil degranulation; DAP12 signaling; Amyloid fiber formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Modulation by Mtb of host immune system; Nef mediated downregulation of MHC class I complex cell surface expression; Endosomal/Vacuolar pathway","IL-18 signaling pathway",173.9,228.2,210.7,195.3,155.6,152.7,1.2168387609213662,0.28313801420594065,0.15947993444289316,0.7972939515341955,0.39796478007617136,0.4001553613318212,2929]
["P61962","DDB1- and CUL4-associated factor 7 [OS=Homo sapiens]",17,5,9,5,342,38.9,5.52,25.48,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","DCAF7","ENSG00000136485","","Neddylation; Association of TriC/CCT with target proteins during biosynthesis","Ciliary landscape",1023.7,1136.6,1054.6,945.7,1042,1795.7,0.8497383306021039,-0.2349094504158832,0.5226656229256669,0.28177606363796986,0.6702040417480174,0.17379295742648831,5700]
["P61970","nuclear transport factor 2 [OS=Homo sapiens]",74,6,40,6,127,14.5,5.38,113.91,"transport;other biological processes","other membranes;cytosol;nucleus","other molecular function","NUTF2","ENSG00000102898","","","",6383.4,6690.2,5965.4,5978.4,6305.2,5754.3,1.0554998087360503,0.077926317258658,0.27489377173418594,0.5608350998513919,0.5091734864686176,0.2931342188835913,3946]
["P62136-1","serine/threonine-protein phosphatase PP1-alpha catalytic subunit [OS=Homo sapiens]",59,15,107,4,330,37.5,6.33,384.55,"cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","LOC111149674; Ppp1ca; PPP1CA","ENSAMEG00000000758; ENSANAG00000023829; ENSBIXG00000010347; ENSBIXG00005003445; ENSBTAG00000012146; ENSCAFG00000041420; ENSCATG00000031120; ENSCCAG00000020614; ENSCHIG00000012800; ENSCJAG00000000983; ENSCPOG00000032835; ENSCSAG00000008548; ENSECAG00000010532; ENSFCAG00000028502; ENSG00000172531; ENSGGOG00000009981; ENSHGLG00000013028; ENSLCNG00005013643; ENSMLUG00000005112; ENSMMUG00000017278; ENSMNEG00000042253; ENSMPUG00000003801; ENSNLEG00000006360; ENSOARG00000011318; ENSOGAG00000033516; ENSPANG00000009836; ENSPCOG00000026258; ENSPCTG00005022585; ENSPPYG00000002995; ENSRFEG00010000614; ENSRNOG00000018708; ENSSHAG00000030720; ENSSSCG00000012913; ENSSSCG00070006658; ENSVURG00010024750; ENSVVUG00000010423","mRNA surveillance pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Oocyte meiosis; Cellular senescence; Adrenergic signaling in cardiomyocytes; Vascular smooth muscle contraction; Hippo signaling pathway; Focal adhesion; Platelet activation; Long-term potentiation; Dopaminergic synapse; Inflammatory mediator regulation of TRP channels; Regulation of actin cytoskeleton; Insulin signaling pathway; Oxytocin signaling pathway; Insulin resistance; Amphetamine addiction; Alcoholism; Herpes simplex virus 1 infection; Proteoglycans in cancer; Diabetic cardiomyopathy","DARPP-32 events; Circadian Clock; Triglyceride catabolism; Downregulation of TGF-beta receptor signaling; DARPP-32 events; DARPP-32 events","Sphingolipid pathway; Nicotine effect on dopaminergic neurons; Common pathways underlying drug addiction; Vascular smooth muscle contraction; Focal adhesion; VEGFA-VEGFR2 signaling pathway; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Netrin-UNC5B signaling pathway; Neuroinflammation and glutamatergic signaling",3245.9,3253.6,3176,3137.1,3261,2542.7,1.0821738546886186,0.11393229135379057,0.3338892146733359,0.4763976093478653,0.5490205331940184,0.2604114127701248,4445]
["P62256","ubiquitin-conjugating enzyme E2 H [OS=Homo sapiens]",28,6,8,6,183,20.6,4.67,23.56,"protein metabolism;other metabolic processes","cytosol;nucleus","other molecular function","UBE2H","ENSG00000186591","Ubiquitin mediated proteolysis","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation","Ciliary landscape",1578.2,1468.7,1528.4,1962.5,1783.9,832,0.9993229075659621,-9.7716875093884653E-4,0.997800174734671,9.5642434322241847E-4,0.9984832252376383,6.5922698549197465E-4,7304]
["P62266","40S ribosomal protein S23 [OS=Homo sapiens]",52,7,57,7,143,15.8,10.49,177.3,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytosol;ER/Golgi;translational apparatus;nucleus;other cell component","other molecular function","RPS23","ENSG00000186468","Ribosome; Coronavirus disease","Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",7931.1,8139.9,7227.5,8889.7,8621.3,8194.3,0.9063695035654127,-0.141828774985681,0.0790544484795579,1.102073686822634,0.28876010191758555,0.5394628135748725,2001]
["P62312","U6 snRNA-associated Sm-like protein LSm6 [OS=Homo sapiens]",43,4,6,4,80,9.1,9.58,13.28,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","LSM6","ENSG00000164167","RNA degradation; Spliceosome","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease","",1379.9,1279.5,1304.5,1337.1,1379.1,1448.8,0.9517166866746699,-0.07139592845589349,0.20564034593646638,0.6868916742167326,0.44653157707951063,0.35014782397256466,3366]
["P62487","DNA-directed RNA polymerase II subunit rpb7 [OS=Homo sapiens]",38,5,9,5,172,19.3,5.54,24.31,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POLR2G","ENSG00000168002","RNA polymerase; Huntington disease","FGFR2 alternative splicing; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere","Pyrimidine metabolism; Eukaryotic transcription initiation",789.7,840,811.7,996.7,965.9,1294.6,0.7495394817634778,-0.415923621191653,0.06198951789270056,1.2076817412472975,0.2581660320670931,0.5881009001651675,1755]
["P62633-1","Cellular nucleic acid-binding protein [OS=Homo sapiens]",50,9,54,1,177,19.5,7.71,136.79,"DNA metabolism;other metabolic processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","Cnbp; CNBP; LOC101344172; LOC111159043; LOC113917796","ENSAMEG00000015334; ENSBIXG00000009042; ENSBMUG00000014129; ENSCAFG00000004320; ENSCANG00000042967; ENSCATG00000020089; ENSCCAG00000034056; ENSCGRG00001000923; ENSCJAG00000017430; ENSCPOG00000032294; ENSCSAG00000008817; ENSDLEG00000010302; ENSECAG00000009512; ENSFCAG00000042197; ENSG00000169714; ENSHGLG00000002069; ENSLAFG00000002502; ENSLCNG00005005148; ENSMFAG00000030262; ENSMLEG00000041892; ENSMMUG00000058753; ENSMNEG00000028473; ENSMPUG00000017315; ENSNLEG00000035879; ENSOCUG00000008696; ENSPANG00000007815; ENSPCTG00005021559; ENSPPYG00000013423; ENSPTRG00000015369; ENSRBIG00000030361; ENSRNOG00000010239; ENSRROG00000045469; ENSSBOG00000023735; ENSSSCG00070013675; ENSSTOG00000000173; ENSTSYG00000004344; ENSTTRG00000015266; ENSVVUG00000018264","","","",5191.8,5525.3,5043,8275.2,7904.2,6269.5,0.702043307244453,-0.5103680654690956,0.02432626173085668,1.6139246249121137,0.1647828053668503,0.7830881077110514,1079]
["P62753","40S RIBOSOMAL PROTEIN S6 [OS=Homo sapiens]",43,13,163,13,249,28.7,10.84,526.71,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;ER/Golgi;translational apparatus;nucleus;other cell component","other molecular function","RPS6","ENSG00000137154","EGFR tyrosine kinase inhibitor resistance; Ribosome; HIF-1 signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Apelin signaling pathway; Thermogenesis; Insulin signaling pathway; Coronavirus disease; Proteoglycans in cancer","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); mTORC1-mediated signalling; rRNA modification in the nucleus and cytosol; Nuclear events stimulated by ALK signaling in cancer","IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Thermogenesis; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Cytoplasmic ribosomal proteins; EGFR tyrosine kinase inhibitor resistance; IL-2 signaling pathway; Malignant pleural mesothelioma; Interferon type I signaling pathways",18605.8,17572.7,16894.7,18514.7,17848.3,17554.3,0.9843445424752351,-0.022764715585531312,0.6490603608770147,0.18771491309664434,0.759037148424016,0.1197369685567466,6250]
["P62826","GTP-binding nuclear protein RAN [OS=Homo sapiens]",66,10,91,10,216,24.4,7.49,277.36,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;other biological processes","cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RAN","ENSG00000132341","Ribosome biogenesis in eukaryotes; Nucleocytoplasmic transport; Human T-cell leukemia virus 1 infection","Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Nuclear import of Rev protein; Transcriptional regulation by small RNAs; tRNA processing in the nucleus; Regulation of cholesterol biosynthesis by SREBP (SREBF); MicroRNA (miRNA) biogenesis; Postmitotic nuclear pore complex (NPC) reformation","Androgen receptor signaling pathway; miRNA biogenesis; 22q11.2 copy number variation syndrome",12623.1,12604.6,12900.5,11756.3,11128.9,11932.9,1.0950683696123569,0.13102094601045777,0.013580884292409404,1.8670719509089477,0.12677226474229927,0.8969757510829183,783]
["P62854","40S ribosomal protein S26 [OS=Homo sapiens]",21,2,7,2,115,13,11,24.57,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;translational apparatus;nucleus","nucleic acid binding activity;other molecular function","RPS26","ENSG00000197728","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Peptide chain elongation; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",707.1,598.3,686.4,719.6,669.4,815.8,0.9033925979680697,-0.1465750019205535,0.26172995378447084,0.5821465715179984,0.49752515792215796,0.3031849537714753,3845]
["P62913","60S ribosomal protein L11 [OS=Homo sapiens]",49,8,53,8,178,20.2,9.6,142.44,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;translational apparatus;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","RPL11","ENSG00000142676","Ribosome; Coronavirus disease","Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",8347.7,7982.2,7737.3,9705.4,9531.4,4948.7,0.9951086394740651,-0.00707405659329778,0.9811341710689448,0.008271598358615347,0.9865331759998511,5.88830533181103E-3,7269]
["P62937-2","Isoform 2 of Peptidyl-prolyl cis-trans isomerase A [OS=Homo sapiens]",90,12,899,1,105,11.4,7.9,1952.98,"","","","PPIA","","","","",606.5,463.5,786.2,461.9,292.7,159.7,2.0301870283276826,1.0216126399286,0.07010482274797232,1.1542521044186949,0.2721169142139828,0.5652444625513868,1883]
["P63027","Vesicle-associated membrane protein 2 [OS=Homo sapiens]",34,4,16,1,116,12.7,8.13,54.84,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","VAMP2","ENSG00000220205","SNARE interactions in vesicular transport; Synaptic vesicle cycle; Insulin secretion; Vasopressin-regulated water reabsorption; Salivary secretion","Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; GABA synthesis, release, reuptake and degradation; Cargo recognition for clathrin-mediated endocytosis; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Sensory processing of sound by inner hair cells of the cochlea; Lysosome Vesicle Biogenesis; trans-Golgi Network Vesicle Budding; Golgi Associated Vesicle Biogenesis; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; Regulation of insulin secretion; Insulin processing; Other interleukin signaling; Toxicity of tetanus toxin (tetX); Toxicity of botulinum toxin type B (botB); Toxicity of botulinum toxin type D (botD); Toxicity of botulinum toxin type G (botG); Toxicity of botulinum toxin type F (botF)","Synaptic vesicle pathway; Insulin signaling; 7q11.23 copy number variation syndrome; Galanin receptor pathway; Sudden infant death syndrome (SIDS) susceptibility pathways",1149.1,1386.4,1155.7,1288,1639.9,2775.2,0.6472269467482595,-0.6276564204773406,0.21489314794199801,0.6677774321512864,0.45658547043839054,0.3404779128388436,3440]
["P63208","s-phase kinase-associated protein 1 [OS=Homo sapiens]",63,10,50,10,163,18.6,4.54,140.14,"protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","SKP1","ENSG00000113558","Cell cycle; Oocyte meiosis; Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum; Wnt signaling pathway; TGF-beta signaling pathway; Circadian rhythm; Shigellosis; Salmonella infection; Human immunodeficiency virus 1 infection; Pathways in cancer","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Regulation of RUNX2 expression and activity; Circadian Clock; Antigen processing: Ubiquitination & Proteasome degradation; Nuclear events stimulated by ALK signaling in cancer; SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Neddylation; SCF(Skp2)-mediated degradation of p27/p21; Negative regulation of NOTCH4 signaling; Regulation of PLK1 Activity at G2/M Transition; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Cyclin D associated events in G1; Regulation of BACH1 activity; MAP3K8 (TPL2)-dependent MAPK1/3 activation; NOTCH1 Intracellular Domain Regulates Transcription; Prolactin receptor signaling; Iron uptake and transport; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling","Cell cycle; TNF-alpha signaling pathway; TGF-beta signaling pathway; Breast cancer pathway; Small cell lung cancer; Notch signaling pathway (Netpath)",4175.2,3427.2,3528.1,5491.8,6301.1,4832,0.6695077865130015,-0.5788272604007064,0.019521373770137466,1.7094896231551502,0.14893707816903418,0.8269971703497218,958]
["P63279","SUMO-conjugating enzyme ubc9 [OS=Homo sapiens]",25,2,5,2,158,18,8.66,15.5,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","UBE2I","ENSG00000103275","Nucleocytoplasmic transport; NF-kappa B signaling pathway; Ubiquitin mediated proteolysis; MicroRNAs in cancer","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; Formation of Incision Complex in GG-NER; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; SUMOylation of intracellular receptors; Vitamin D (calciferol) metabolism; SUMOylation of transcription factors; Postmitotic nuclear pore complex (NPC) reformation; Negative regulation of activity of TFAP2 (AP-2) family transcription factors; Maturation of nucleoprotein; SUMOylation of immune response proteins; Maturation of nucleoprotein; SUMO is transferred from E1 to E2 (UBE2I, UBC9)","Androgen receptor signaling pathway; TGF-beta signaling pathway",630.7,585.3,507.6,740,735.9,271.4,0.9864362158759227,-0.019702327278136995,0.9628995735769615,0.016419005622814103,0.9749041395309617,0.011038085552181652,7219]
["P67936","Tropomyosin alpha-4 chain [OS=Homo sapiens]",59,19,105,8,248,28.5,4.69,249.85,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","cytoskeletal activity;other molecular function","TPM4","ENSG00000167460","Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Hypertrophic cardiomyopathy; Dilated cardiomyopathy","Smooth Muscle Contraction; Striated Muscle Contraction; RHOV GTPase cycle; Signaling by ALK fusions and activated point mutants","Striated muscle contraction pathway",5085,4052.9,3889.1,5573.3,7100.9,6903,0.6654169135524998,-0.5876695578096561,0.022989248417974104,1.6384752267847478,0.15926864140945282,0.7978697245344862,1055]
["P68133","Actin, alpha skeletal muscle [OS=Homo sapiens]",40,18,1223,3,377,42,5.39,3506.87,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ACTA1","ENSG00000143632","","Striated Muscle Contraction","Myometrial relaxation and contraction pathways; Fas ligand pathway and stress induction of heat shock proteins; Physico-chemical features and toxicity-associated pathways; Striated muscle contraction pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; IL-18 signaling pathway; Malignant pleural mesothelioma",43607.8,43511.3,41183.7,36132.3,36751.4,30290.6,1.2435538695198316,0.3144690050262903,0.01913820156039006,1.7180988758118239,0.1478658723096099,0.8301320503296437,946]
["P69905","Hemoglobin subunit alpha [OS=Homo sapiens]",22,3,75,3,142,15.2,8.68,198.38,"other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;cytosol;translational apparatus;other cell component","other molecular function","HBA1; HBA2","ENSG00000188536; ENSG00000206172","African trypanosomiasis; Malaria","Heme signaling; Scavenging of heme from plasma; Cytoprotection by HMOX1; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Effects of nitric oxide",9782.2,9219.7,8892.2,7865.2,8607.6,9512.5,1.0734569160255993,0.10226428874344734,0.30601015214158445,0.5142641651983796,0.5335468039128913,0.2728274772900769,4192]
["P78345","Ribonuclease P protein subunit p38 [OS=Homo sapiens]",18,4,6,4,283,31.8,9.92,14.17,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RPP38","ENSG00000152464","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus","Integrated breast cancer pathway; Sphingolipid metabolism in senescence",305.6,289.8,277.7,354.4,394.1,646.7,0.6257884174311927,-0.6762531385603968,0.1311622307644053,0.8821912056010788,0.3663220269992504,0.43613696635698684,2617]
["P78356","Phosphatidylinositol 5-phosphate 4-kinase type-2 beta [OS=Homo sapiens]",31,11,34,6,416,47.3,7.33,83,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle","kinase activity;other molecular function","PIP4K2B","ENSG00000276293; ENSG00000277292","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Regulation of actin cytoskeleton","Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs in the nucleus","Regulation of actin cytoskeleton",1361.7,1422,1419.6,1416.7,1369,1797.6,0.9170903061113171,-0.12486429153138288,0.4076485919248847,0.38971405345109705,0.5908196625776289,0.22854505972625747,5043]
["P78410-1","Butyrophilin subfamily 3 member A2 [OS=Homo sapiens]",25,6,11,4,334,36.4,5.33,34.54,"signal transduction;other biological processes","plasma membrane;other membranes","signal transduction activity or receptor binding","BTN3A2","ENSG00000186470","","Butyrophilin (BTN) family interactions","",1052,1087.5,1066.6,1023.1,1030.7,2349.8,0.7280634026705423,-0.4578640033432851,0.41666958603788123,0.3802081988419241,0.5959761260960614,0.22477113709266383,5110]
["P80297","metallothionein-1X [OS=Homo sapiens]",20,1,1,1,61,6.1,7.96,2.54,"stress response;other biological processes","nucleus;other cell component","other molecular function","MT1X","ENSG00000187193","Mineral absorption","Metallothioneins bind metals","Copper homeostasis; Zinc homeostasis; Oxidative stress response",54.3,55.5,58.2,37.4,43.8,45.9,1.3217938630999213,0.40249720266116373,0.008270470068069302,2.0824698057839788,0.10091630338483895,0.996038666289317,599]
["P80303","Nucleobindin-2 [OS=Homo sapiens]",8,3,4,3,420,50.2,5.12,11.01,"","","","","","","","",334.6,279.2,358,549.9,675.7,1040.7,0.42880465957728453,-1.2216075120568892,0.04431960438421569,1.3534041249610103,0.22006249214961446,0.6574539730785173,1472]
["P82673-1","28S ribosomal protein S35, mitochondrial [OS=Homo sapiens]",30,9,16,8,323,36.8,8.24,39.55,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPS35","ENSG00000061794","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1777,1555.9,1576.3,2088.7,2153.6,1718,0.8236498162844152,-0.27989700467798584,0.08375810922108998,1.0769731351032774,0.29660272301208657,0.5278248661744781,2064]
["P82912-1","28S ribosomal protein S11, mitochondrial [OS=Homo sapiens]",34,4,10,4,194,20.6,10.81,31.36,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes","other membranes;cytosol;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPS11","ENSG00000181991","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",874.9,998.9,1015.4,924.6,883.1,973.7,1.0387574602718055,0.05485883835156518,0.5237304960905219,0.280892137005087,0.6708633361243647,0.17336594244217157,5706]
["P82987-1","ADAMTS-like protein 3 [OS=Homo sapiens]",1,1,1,1,1691,188.6,7.83,0,"cell organization and biogenesis;protein metabolism","non-structural extracellular;extracellular matrix;other cell component","other molecular function","ADAMTSL3","ENSG00000156218","","Defective B3GALTL causes PpS; O-glycosylation of TSR domain-containing proteins","",28.9,19.6,21.2,24.2,24.2,2.5,1.369351669941061,0.45349299979272795,0.4658116344181731,0.331789668440858,0.6300179933313151,0.20064704690687804,5404]
["P84077","ADP-ribosylation factor 1 [OS=Homo sapiens]",73,11,196,5,181,20.7,6.8,662.51,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","ARF1","ENSG00000143761","Phospholipase D signaling pathway; Endocytosis; Vibrio cholerae infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Legionellosis","COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; COPI-mediated anterograde transport; Synthesis of PIPs at the plasma membrane; Intra-Golgi traffic; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis; trans-Golgi Network Vesicle Budding; Synthesis of PIPs at the Golgi membrane; Nef Mediated CD4 Down-regulation","Cell migration and invasion through p75NTR; Neural crest cell migration during development; Neural crest cell migration in cancer; Insulin signaling",16482.6,17503.1,15859.9,14093.5,15437.3,15953.2,1.09589306129628,0.1321070250642135,0.11817458910784978,0.9274758990610437,0.3471616044169108,0.4594683131958518,2488]
["P84095","Rho-related GTP-binding protein RhoG [OS=Homo sapiens]",60,8,48,7,191,21.3,8.12,179.23,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","RHOG","ENSG00000177105","Bacterial invasion of epithelial cells; Salmonella infection; Yersinia infection","Neutrophil degranulation; RHOG GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; RHO GTPases activate KTN1","Brain-derived neurotrophic factor (BDNF) signaling pathway",3543.9,3537.6,3504.5,2939.9,2946.6,2889.9,1.2061893259195113,0.2704563733472842,9.8965978439703687E-6,5.004514077273954,0.018083558410394857,1.7427161067179433,4]
["P98155-1","very low-density lipoprotein receptor [OS=Homo sapiens]",1,1,1,1,873,96,4.79,1.97,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","VLDLR","ENSG00000147852","Spinocerebellar ataxia; Lipid and atherosclerosis","VLDLR internalisation and degradation; Reelin signalling pathway; VLDL clearance","Familial hyperlipidemia type 3",29.5,21.4,21.3,30.1,24,29.4,0.8646706586826347,-0.2097773604742436,0.3213487739009897,{"$f":"-LOG10(AA2499)","v":0.4930233527912357},0.5416831615411287,{"$f":"-LOG10(AC2499)","v":0.2662546644375932},4336]
["P99999","cytochrome c [OS=Homo sapiens]",41,4,26,4,105,11.7,9.57,56.92,"other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus","other molecular function","CYCS","ENSG00000172115","Oxidative phosphorylation; Metabolic pathways; Platinum drug resistance; p53 signaling pathway; Apoptosis; Apoptosis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Legionellosis; Toxoplasmosis; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Colorectal cancer; Small cell lung cancer; Viral myocarditis; Lipid and atherosclerosis","Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Respiratory electron transport; TP53 Regulates Metabolic Genes; Detoxification of Reactive Oxygen Species; Formation of apoptosome; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity; Release of apoptotic factors from the mitochondria; Pyroptosis","miRNA regulation of DNA damage response; Alzheimer's disease and miRNA effects; AGE/RAGE pathway; Parkinson's disease pathway; Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; VEGFA-VEGFR2 signaling pathway; Oxidative damage response; NO/cGMP/PKG mediated neuroprotection; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Acute viral myocarditis; Nonalcoholic fatty liver disease; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Malignant pleural mesothelioma; Complement system in neuronal development and plasticity; Alzheimer's disease; DNA damage response",2505.9,2574.8,2430.5,2887.8,2643.8,1661.9,1.0441648710641551,0.062349527891518805,0.7926941474934426,0.1008943482159433,0.8597420276049224,0.06563184270367269,6739]
["Q00013-1","55 kDa erythrocyte membrane protein [OS=Homo sapiens]",25,11,13,11,466,52.3,7.37,29.49,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","kinase activity","MPP1","ENSG00000130830; ENSGGOG00000001049; ENSPPAG00000040588; ENSPTRG00000022450; ENSPTRG00000051407","","Sensory processing of sound by outer hair cells of the cochlea","MECP2 and associated Rett syndrome",1344.1,1328.5,1358.5,1307,1263,1872.7,0.9073536363022487,-0.14026315173575943,0.5235063006896858,0.28107808697788783,0.6706936988152347,0.17347577384814833,5705]
["Q00577","Transcriptional activator protein Pur-alpha [OS=Homo sapiens]",43,9,24,9,322,34.9,6.44,87.56,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","PURA","ENSG00000185129","","","Exercise-induced circadian regulation",3077.6,3051.1,3051.7,3082,3126.9,1980.6,1.120996397826485,0.1647816422412735,0.4281035877205271,0.3684511325471469,0.6039392245993693,0.21900676295029514,5181]
["Q00653-1","Nuclear factor NF-kappa-B p100 subunit [OS=Homo sapiens]",34,22,60,21,900,96.7,6.25,196.7,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NFKB2","ENSG00000077150","MAPK signaling pathway; NF-kappa B signaling pathway; Osteoclast differentiation; C-type lectin receptor signaling pathway; Legionellosis; Human T-cell leukemia virus 1 infection; Epstein-Barr virus infection; Pathways in cancer; Viral carcinogenesis; Breast cancer","Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; PKMTs methylate histone lysines; RIP-mediated NFkB activation via ZBP1; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; Interleukin-1 processing; DEx/H-box helicases activate type I IFN and inflammatory cytokines production ; SUMOylation of immune response proteins","Regulation of toll-like receptor signaling pathway; Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Neural crest differentiation; Thymic stromal lymphopoietin (TSLP) signaling pathway; TNF-alpha signaling pathway; Ebstein-Barr virus LMP1 signaling; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Toll-like receptor signaling related to MyD88; ApoE and miR-146 in inflammation and atherosclerosis; Ebola virus pathway in host; Breast cancer pathway; Acute viral myocarditis; miRNAs involvement in the immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Interactions between immune cells and microRNAs in tumor microenvironment; Head and neck squamous cell carcinoma; IL-18 signaling pathway; FGF23 signaling in hypophosphatemic rickets and related disorders; Mitochondrial immune response to SARS-CoV-2; Neuroinflammation and glutamatergic signaling; Network map of SARS-CoV-2 signaling pathway; Inclusion body myositis; Sudden infant death syndrome (SIDS) susceptibility pathways",6477.9,6584.7,6369.8,8031,7792.6,7409.6,0.8364065217017026,-0.2577237838087191,2.6975513510338134E-3,2.569030279264753,0.05920841689100944,1.2276165508870995,333]
["Q00987-1","E3 ubiquitin-protein ligase Mdm2 [OS=Homo sapiens]",14,6,9,6,491,55.2,4.69,20.89,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","MDM2","ENSG00000135679","Endocrine resistance; Platinum drug resistance; FoxO signaling pathway; Cell cycle; p53 signaling pathway; Ubiquitin mediated proteolysis; Endocytosis; PI3K-Akt signaling pathway; Cellular senescence; C-type lectin receptor signaling pathway; Thyroid hormone signaling pathway; Shigellosis; Human cytomegalovirus infection; Human papillomavirus infection; Epstein-Barr virus infection; Pathways in cancer; Transcriptional misregulation in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Glioma; Prostate cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia","Ub-specific processing proteases; Oxidative Stress Induced Senescence; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of RUNX3 expression and activity; SUMOylation of ubiquitinylation proteins; SUMOylation of transcription factors; Regulation of TP53 Degradation; Regulation of TP53 Activity through Phosphorylation; Oncogene Induced Senescence; Regulation of TP53 Activity through Methylation; AKT phosphorylates targets in the cytosol; Stabilization of p53; Trafficking of AMPA receptors","Androgen receptor signaling pathway; miRNA regulation of DNA damage response; TP53 network; Cell cycle; Glioblastoma signaling pathways; Retinoblastoma gene in cancer; Apoptosis; Bladder cancer; Copper homeostasis; VEGFA-VEGFR2 signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of p53 pathway in prostate cancer; PI3K-Akt signaling pathway; Genotoxicity pathway; G1 to S cell cycle control; Male infertility; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; Malignant pleural mesothelioma; Senescence and autophagy in cancer; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)",700.6,745,702.1,530,545.9,1817.5,0.7422755236054468,-0.4299732978564227,0.5915406865571822,0.22801537894884435,0.7180818598316633,0.14382604427201937,6021]
["Q01167","Forkhead box protein K2 [OS=Homo sapiens]",8,5,12,4,660,69,9.54,25.47,"other metabolic processes;stress response;other biological processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","FOXK2","ENSG00000141568","","UCH proteinases","",534.3,531,527.3,582.5,557,677.6,0.8764514886357384,-0.19025385449181917,0.1114247270057261,0.9530184212763562,0.3380669695661487,0.47099725939072656,2409]
["Q01518-1","adenylyl cyclase-associated protein 1 [OS=Homo sapiens]",53,23,275,1,475,51.9,8.06,908.04,"cell organization and biogenesis;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","CAP1","ENSG00000131236","","Neutrophil degranulation; Platelet degranulation ; Role of ABL in ROBO-SLIT signaling","Angiopoietin-like protein 8 regulatory pathway; Insulin signaling; Complement system in neuronal development and plasticity",552.8,616.5,565.9,597.1,577.2,848.1,0.8579905063291139,-0.220966410504829,0.34412288627527754,0.4632864431810398,0.5553530968836395,0.25543080198002405,4529]
["Q01581","hydroxymethylglutaryl-CoA synthase, cytoplasmic [OS=Homo sapiens]",20,9,22,9,520,57.3,5.41,67.63,"other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","other molecular function","HMGCS1","ENSG00000112972","Valine, leucine and isoleucine degradation; Butanoate metabolism; Terpenoid backbone biosynthesis; Metabolic pathways; PPAR signaling pathway","PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Endochondral ossification; Endochondral ossification with skeletal dysplasias",2620.3,2758.7,2660.3,5696.1,5759.4,3125.9,0.5513393775631971,-0.8589874501309785,0.06598511363054371,1.1805540310842153,0.2655755481969405,0.5758119133853088,1816]
["Q01974","Tyrosine-protein kinase transmembrane receptor ROR2 [OS=Homo sapiens]",3,3,3,3,943,104.7,6.55,6.43,"cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","ROR2","ENSG00000169071","Wnt signaling pathway","WNT5A-dependent internalization of FZD2, FZD5 and ROR2","Cardiac progenitor differentiation; Ectoderm differentiation; Wnt signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Malignant pleural mesothelioma",349.1,371.4,674.1,382,433.9,580.4,0.9987824965981521,-1.7575562527062376E-3,0.996472394016429,1.5347283658042105E-3,0.9975642689859032,1.059114922618934E-3,7301]
["Q02040-1","A-kinase anchor protein 17A [OS=Homo sapiens]",16,12,23,12,695,80.7,9.73,49.25,"RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus","other molecular function","AKAP17A","ENSG00000197976","","","",2592.1,2530.6,2544.1,2736.8,2832,2643.9,0.9335297770526134,-0.09923205366674778,0.03388574590279598,1.4699829501035497,0.1922910844747949,0.71604085124337,1288]
["Q02241-1","Kinesin-like protein KIF23 [OS=Homo sapiens]",27,19,31,19,960,110,8.51,90.01,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KIF23","ENSG00000137807","MicroRNAs in cancer","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; MHC class II antigen presentation; Mitotic Telophase/Cytokinesis","Malignant pleural mesothelioma",2465,2430.1,2413.2,1867.2,1940.4,1736.3,1.3182597088692074,0.3986346220815824,6.7279612420093255E-4,3.1721165190576417,0.033226127512058216,1.4785202725686262,148]
["Q02383","Semenogelin-2 [OS=Homo sapiens]",1,1,2,1,582,65.4,9.07,4.54,"stress response;other biological processes","non-structural extracellular","other molecular function","SEMG2","ENSG00000124157","","","Genotoxicity pathway",339.6,358.3,313.8,377.9,362.2,513.4,0.8071001196649382,-0.3091804459384502,0.180187907363912,0.7442743584254742,0.4230624525932646,0.37359551722401657,3113]
["Q02556","Interferon regulatory factor 8 [OS=Homo sapiens]",2,1,2,1,426,48.3,6.77,2.2,"other metabolic processes;stress response;transport;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","IRF8","ENSG00000140968","Pertussis","Interferon gamma signaling; Interferon alpha/beta signaling","Vitamin D receptor pathway; Development of pulmonary dendritic cells and macrophage subsets; Type II interferon signaling (IFNG)",58.6,62.2,60.2,80.7,51.5,4163.5,0.042135158414228185,-4.568831640523949,0.37210040009393475,0.4293398630112671,0.5701639044625931,0.24400028016740802,4770]
["Q03001-7","dystonin [OS=Homo sapiens]",12,83,135,79,7570,860.1,5.25,375.37,"cell adhesion;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","DST","ENSG00000151914","","RND1 GTPase cycle; RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; Type I hemidesmosome assembly","",11395.9,11244,11708.4,13901.4,13249.9,12874.6,0.8581518466792752,-0.2206951452180644,0.004561113414662432,2.340929128647096,0.0755945078180674,1.1215097562309617,441]
["Q03252","Lamin-B2 [OS=Homo sapiens]",64,48,309,41,620,69.9,5.59,891.24,"","other membranes;cytoskeleton;nucleus","other molecular function","LMNB2","ENSG00000176619","Apoptosis","","Gastric cancer network 2; Fas ligand pathway and stress induction of heat shock proteins; IL-18 signaling pathway; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome",33494.4,33134.2,34897.7,37355.7,34099.4,36810.3,0.9377538899777768,-0.09271875242049707,0.12048369243553786,0.9190717312180262,0.35084275219575545,0.4548874908150914,2510]
["Q03468","DNA excision repair protein ERCC-6 [OS=Homo sapiens]",3,4,4,4,1493,168.3,8.09,11.65,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","ERCC6","ENSG00000225830","Nucleotide excision repair","Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; B-WICH complex positively regulates rRNA expression; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression","Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum",392.7,366.4,397.7,445.7,415.7,379,0.9326023863269911,-0.1006659736615049,0.26639528183449596,0.5744734712862287,0.5024730619169887,0.2988872162445848,3875]
["Q04656-1","copper-transporting ATPase 1 [OS=Homo sapiens]",8,8,15,8,1500,163.3,6.24,40.93,"","","","","","","","",1109.5,1112.5,1187.1,1178.6,1128.2,1399.4,0.9198370298418864,-0.12054981748488765,0.31884465747468643,0.49642085560538146,0.5407043158892072,0.2670401638821401,4310]
["Q04695","Keratin, type I cytoskeletal 17 [OS=Homo sapiens]",27,12,31,3,432,48.1,5.02,86.77,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","other molecular function","KRT17","ENSG00000128422","Estrogen signaling pathway; Staphylococcus aureus infection","Formation of the cornified envelope","",221.8,202.7,594.3,287.3,360.6,1769.8,0.4213922322868842,-1.2467643743355539,0.402939457724328,0.3947602023736361,0.5881934285015206,0.23047983188857227,5007]
["Q05469-1","hormone-sensitive lipase [OS=Homo sapiens]",9,7,14,7,1076,116.5,6.7,42.9,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","LIPE","ENSG00000079435","cAMP signaling pathway; AMPK signaling pathway; Apelin signaling pathway; Thermogenesis; Insulin signaling pathway; Regulation of lipolysis in adipocytes; Aldosterone synthesis and secretion","Triglyceride catabolism","AMP-activated protein kinase (AMPK) signaling; Fatty acid beta-oxidation; Adipogenesis; Triacylglyceride synthesis; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Lipid metabolism pathway; Thermogenesis; Insulin signaling; Orexin receptor pathway; Familial partial lipodystrophy (FPLD)",689.6,705.7,699.1,682.7,678.1,921.7,0.9175903614457831,-0.124077857813706,0.4799623321073916,0.3187928451240401,0.6407387553192557,0.1933190067522231,5475]
["Q05519","serine/arginine-rich splicing factor 11 [OS=Homo sapiens]",18,10,38,10,484,53.5,10.52,76.07,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","SRSF11","ENSG00000116754","","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript","",4604.2,4457.5,4468.4,4569.3,4557.2,3760.7,1.0498867092929418,0.07023365859677656,0.4743369566352265,0.32391303719193093,0.637185961412768,0.19573380121386255,5441]
["Q06124-2","Isoform 2 of Tyrosine-protein phosphatase non-receptor type 11 [OS=Homo sapiens]",39,21,47,21,593,68,7.3,127.47,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","PTPN11","ENSG00000179295; ENSMMUG00000013253; ENSRROG00000031729","Ras signaling pathway; Phospholipase D signaling pathway; Axon guidance; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; Leukocyte transendothelial migration; Neurotrophin signaling pathway; Adipocytokine signaling pathway; Insulin resistance; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Herpes simplex virus 1 infection; Proteoglycans in cancer; Chemical carcinogenesis; Renal cell carcinoma; Chronic myeloid leukemia; PD-L1 expression and PD-1 checkpoint pathway in cancer","PIP3 activates AKT signaling; GPVI-mediated activation cascade; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by SCF-KIT; RET signaling; Platelet sensitization by LDL; CTLA4 inhibitory signaling; FLT3 Signaling; Interleukin-3, Interleukin-5 and GM-CSF signaling; PD-1 signaling; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; Signal regulatory protein family interactions; PI3K Cascade; Downstream signal transduction; Tie2 Signaling; Interleukin-6 signaling; Signaling by Leptin; Regulation of IFNG signaling; Regulation of IFNA signaling; Signaling by CSF3 (G-CSF); GAB1 signalosome; PI-3K cascade:FGFR1; FRS-mediated FGFR1 signaling; PI-3K cascade:FGFR2; FRS-mediated FGFR2 signaling; FRS-mediated FGFR3 signaling; PI-3K cascade:FGFR3; FRS-mediated FGFR4 signaling; PI-3K cascade:FGFR4; Activated NTRK2 signals through FRS2 and FRS3; Spry regulation of FGF signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; Prolactin receptor signaling; Interleukin-20 family signaling; Netrin mediated repulsion signals; Interleukin-37 signaling; Signaling by FLT3 ITD and TKD mutants; PECAM1 interactions; MET activates PTPN11; STAT5 activation downstream of FLT3 ITD mutants; Regulation of RUNX1 Expression and Activity; STAT5 Activation","IL-5 signaling pathway; Heart development; IL-1 signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Pilocytic astrocytoma; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL-6 signaling pathway; Hepatitis C and hepatocellular carcinoma; VEGFA-VEGFR2 signaling pathway; Embryonic stem cell pluripotency pathways; IL-4 signaling pathway; Ras signaling; EGF/EGFR signaling pathway; Fragile X syndrome; Cancer immunotherapy by CTLA4 blockade; Cancer immunotherapy by PD-1 blockade; Gastrin signaling pathway; Netrin-UNC5B signaling pathway; Insulin signaling; IL-2 signaling pathway; Angiotensin II receptor type 1 pathway; Kallmann syndrome; Interferon type I signaling pathways; Type II interferon signaling (IFNG); T-cell receptor (TCR) signaling pathway",5759.8,5759.6,5973.3,5829.4,5349.3,5228,{"$f":"AVERAGE(S2626:U2626)/AVERAGE(V2626:X2626)","v":1.0661924701493901},{"$f":"LOG(Y2626,2)","v":0.09246789838356477},{"$f":"TTEST(V2626:X2626,S2626:U2626,2,2)","v":0.13990372190802275},0.8541707316653178,{"$f":"AA2626*7309/AE2626","v":0.3759398174359332},0.42488167381554354,2720]
["Q06481","Amyloid-like protein 2 [OS=Homo sapiens]",4,4,4,4,763,86.9,4.79,8.09,"signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","APLP2","ENSG00000084234","","Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","Splicing factor NOVA regulated synaptic proteins",553,577.5,579.5,455,450.7,610.3,1.1279683377308707,0.17372657160216848,0.29087594754772916,0.5362921889597737,0.522490120576641,0.281921916929086,4069]
["Q07020","60S ribosomal protein L18 [OS=Homo sapiens]",46,8,48,8,188,21.6,11.72,150.29,"protein metabolism;other metabolic processes","cytosol;ER/Golgi;translational apparatus;nucleus","nucleic acid binding activity;other molecular function","RPL18","ENSG00000063177","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis","Cytoplasmic ribosomal proteins",6429.4,6473.8,5902,6706,7625.6,6459.6,0.9044788179614452,-0.14484137819873452,0.17285773071521351,0.7623111927378277,0.41464297794469823,0.38232568507652825,3047]
["Q07157","Tight junction protein ZO-1 [OS=Homo sapiens]",18,28,46,26,1748,195.3,6.7,137.15,"cell adhesion;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","TJP1","ENSG00000104067; ENSG00000277401","Adherens junction; Tight junction; Gap junction; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection","RUNX1 regulates expression of components of tight junctions; Signaling by Hippo; Apoptotic cleavage of cell adhesion  proteins; Regulation of gap junction activity","Epithelial to mesenchymal transition in colorectal cancer; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; Disruption of postsynaptic signaling by CNV; 1q21.1 copy number variation syndrome",4170.4,4080.4,4169.6,5215.9,4976.2,7524.5,0.7010600228034725,-0.5123901258386108,0.09564880466920658,1.0193204530157904,0.3170508450463632,0.4988710849356747,2205]
["Q07866-6","Isoform N of Kinesin light chain 1 [OS=Homo sapiens]",38,25,77,21,628,71,6.67,227.5,"","","","KLC1","","","","",9367.5,9491.2,8957.4,9975.5,10145.3,6531.6,1.0436621092284373,0.06165470784368436,0.76046045878075,0.11892336278097013,0.8379625347849392,0.0767753981953735,6633]
["Q07889","Son of sevenless homolog 1 [OS=Homo sapiens]",7,8,10,8,1333,152.4,6.84,23.92,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","SOS1","ENSG00000115904","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Chemokine signaling pathway; FoxO signaling pathway; Phospholipase D signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Focal adhesion; Gap junction; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Thermogenesis; Neurotrophin signaling pathway; Regulation of actin cytoskeleton; Insulin signaling pathway; GnRH signaling pathway; Estrogen signaling pathway; Prolactin signaling pathway; Relaxin signaling pathway; Growth hormone synthesis, secretion and action; Alcoholism; Hepatitis C; Hepatitis B; Human cytomegalovirus infection; Human papillomavirus infection; Pathways in cancer; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Endometrial cancer; Glioma; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Choline metabolism in cancer","RAC1 GTPase cycle; Role of LAT2/NTAL/LAB on calcium mobilization; RET signaling; FLT3 Signaling; Downstream signal transduction; Tie2 Signaling; FRS-mediated FGFR1 signaling; FRS-mediated FGFR2 signaling; FRS-mediated FGFR3 signaling; FRS-mediated FGFR4 signaling; Activated NTRK2 signals through FRS2 and FRS3; Signaling by FLT3 ITD and TKD mutants; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; NRAGE signals death through JNK; G alpha (12/13) signalling events; Interleukin receptor SHC signaling; RAF/MAP kinase cascade; DAP12 signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; Regulation of KIT signaling; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; GRB2 events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; GRB2 events in EGFR signaling; SHC1 events in EGFR signaling; NCAM signaling for neurite out-growth; Signaling by FGFR1 in disease; SHC-mediated cascade:FGFR1; SHC-mediated cascade:FGFR2; Signaling by FGFR2 in disease; SHC-mediated cascade:FGFR3; SHC-mediated cascade:FGFR4; Signaling by FGFR3 point mutants in cancer; Activation of RAC1; Erythropoietin activates RAS; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; SOS-mediated signalling; Signalling to RAS; SHC-related events triggered by IGF1R; Signaling by FGFR4 in disease; MET activates RAS signaling; Signaling by FGFR3 fusions in cancer; Activated NTRK2 signals through RAS; Activated NTRK3 signals through RAS; Constitutive Signaling by Overexpressed ERBB2; Signaling by FLT3 fusion proteins; Signal attenuation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Interleukin-15 signaling","IL-5 signaling pathway; Integrin-mediated cell adhesion; Leptin signaling pathway; Prolactin signaling pathway; Pilocytic astrocytoma; B cell receptor signaling pathway; TNF-alpha signaling pathway; Oncostatin M signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL-6 signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Acute viral myocarditis; Thermogenesis; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Malignant pleural mesothelioma; Regulation of actin cytoskeleton; EPO receptor signaling; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent)",746.3,763.7,813.2,809.9,795.5,843.6,0.9486320947325438,-0.07607941545558987,0.16335622634573768,0.7868643076772939,0.40323223855487905,0.39444475318261996,2961]
["Q08378","Golgin subfamily A member 3 [OS=Homo sapiens]",27,31,49,31,1498,167.3,5.44,179.93,"other biological processes","other membranes;cytosol;ER/Golgi;nucleus","","GOLGA3","ENSG00000090615","","RND2 GTPase cycle","",3839.5,3690.1,3845.2,4138.6,4304.2,5305.8,0.8273424203191599,-0.27344353955095996,0.0980469321547386,1.0085659906663902,0.3207811222555884,0.4937911975620075,2234]
["Q08752","peptidyl-prolyl cis-trans isomerase D [OS=Homo sapiens]",59,23,87,22,370,40.7,7.21,264.19,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","PPID","ENSG00000171497","Necroptosis; Cellular senescence; Alzheimer disease; Pathways of neurodegeneration; Shigellosis","ESR-mediated signaling","Alzheimer's disease and miRNA effects; NO/cGMP/PKG mediated neuroprotection; Alzheimer's disease",11843.8,11969.5,11528.8,12414,12837.2,11379.6,0.964819223167389,-0.05166944294374576,0.39605819526816716,0.4022409958246814,0.5846878103847776,0.23307596027219257,4951]
["Q08AD1","Calmodulin-regulated spectrin-associated protein 2 [OS=Homo sapiens]",8,9,11,9,1489,168,6.8,30.42,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi","cytoskeletal activity;other molecular function","CAMSAP2","ENSG00000118200","","","",885.6,841.8,906.9,1041.6,1035.4,2342.4,0.5960763904602435,-0.7464308630657409,0.24320924220669654,0.6140199254391756,0.48082671119522447,0.3180114141283095,3697]
["Q09327","Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase [OS=Homo sapiens]",8,3,3,3,533,61.3,8.28,8.11,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi","other molecular function","MGAT3","ENSG00000128268","N-Glycan biosynthesis; Metabolic pathways","Reactions specific to the hybrid N-glycan synthesis pathway","",139.4,140.4,135.6,235.5,286.9,183.4,0.5885519977330689,-0.7647582139350765,0.031795441496183206,1.4976351402345447,0.18741361443193796,0.7271988635128068,1240]
["Q0P6H9","Transmembrane protein 62 [OS=Homo sapiens]",11,5,7,5,643,73.1,9.26,26.35,"","other membranes","other molecular function","TMEM62","ENSG00000137842","","","",413.7,491.1,481.9,481.6,412.6,618.7,{"$f":"AVERAGE(S2690:U2690)/AVERAGE(V2690:X2690)","v":0.9165840438892193},{"$f":"LOG(Y2690,2)","v":-0.1256609237313893},{"$f":"TTEST(V2690:X2690,S2690:U2690,2,2)","v":0.5545416853793408},0.2560658019949471,{"$f":"AA2690*7309/AE2690","v":0.6916629997333792},0.16010545612906477,5860]
["Q0VDG4-1","secernin-3 [OS=Homo sapiens]",26,9,16,9,424,48.5,5.55,46.04,"protein metabolism","","other molecular function","SCRN3","ENSG00000144306","","","",1430.1,1530.2,1483.3,1498.9,1465.6,1103.5,1.092330383480826,0.1274092761479237,0.3896351754176276,0.40934184286069775,0.5809554257705916,0.23585718789278398,4902]
["Q11201","CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 [OS=Homo sapiens]",15,4,7,4,340,39.1,9.09,28.5,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","ST3GAL1","ENSG00000008513","Mucin type O-glycan biosynthesis; Glycosaminoglycan biosynthesis; Glycosphingolipid biosynthesis; Glycosphingolipid biosynthesis; Metabolic pathways","Maturation of spike protein; Sialic acid metabolism; Keratan sulfate biosynthesis; Maturation of protein 3a; Maturation of protein 3a; Termination of O-glycan biosynthesis","Ganglio sphingolipid metabolism; Globo sphingolipid metabolism",575.5,636.4,601.9,760,842.4,894.8,0.7263334935127344,-0.46129598610762734,0.00610350386415364,2.2144207761373065,0.08747158773156657,1.0581329903512702,510]
["Q12765","Secernin-1 [OS=Homo sapiens]",3,1,1,1,414,46.4,4.75,2.14,"protein metabolism;transport","other membranes;nucleus;other cell component","other molecular function","SCRN1","ENSG00000136193","","","",38.8,38.6,34.7,49.1,27.6,96.7,0.6464821222606689,-0.6293176204164084,0.3744572250920103,0.4265977853543674,0.571498821924724,0.2429846605130021,4789]
["Q12792-2","Twinfilin-1 [OS=Homo sapiens]",40,12,33,9,350,40.3,6.96,94.03,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","TWF1","ENSG00000151239","","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHOBTB2 GTPase cycle","",1882.2,1898.1,1986.9,2219.2,2014.8,2623.6,0.8409939337377509,-0.24983270082552497,0.11624372354731584,0.934630487060412,0.34551662277646666,0.4615310539151561,2459]
["Q12824-1","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 [OS=Homo sapiens]",37,10,52,10,385,44.1,6.23,155.01,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","LOC101347788; LOC111142756; Smarcb1; SMARCB1","ENSCAFG00000014105; ENSCATG00000029590; ENSCCAG00000036123; ENSCHIG00000019816; ENSCSAG00000011285; ENSDLEG00000015913; ENSECAG00000007797; ENSG00000099956; ENSG00000275837; ENSHGLG00000019077; ENSMFAG00000040790; ENSMLUG00000004975; ENSMMUG00000009098; ENSMNEG00000033936; ENSMUSG00000000902; ENSPANG00000026464; ENSPPAG00000028391; ENSRBIG00000027964; ENSRFEG00010017090; ENSRROG00000030710; ENSSBOG00000031674; ENSSSCG00000010070; ENSSSCG00070020965; ENSSSUG00005014167; ENSSTOG00000012408; ENSTSYG00000008262; ENSUAMG00000010813","Thermogenesis; Hepatocellular carcinoma","RMTs methylate histone arginines; RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines","TNF-alpha NF-kB signaling pathway; Tumor suppressor activity of SMARCB1; Thermogenesis; Modulators of TCR signaling and T cell activation",2646.6,2625.8,2731,2911.4,2810.9,2680.2,0.9525022314787264,-0.07020562239739078,0.14769634580626836,0.8306302495479384,0.3845787643384452,0.4150147002984045,2807]
["Q12851","Mitogen-activated protein kinase kinase kinase kinase 2 [OS=Homo sapiens]",13,8,11,8,820,91.5,6.34,30,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi","kinase activity;other molecular function","MAP4K2","ENSG00000168067","MAPK signaling pathway","","TNF-alpha signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Insulin signaling; Malignant pleural mesothelioma",588.7,628.3,620.7,629.5,640.7,731.2,0.918207254921555,-0.1231082637976585,0.18793665232739984,0.7259885134000388,0.4307397277707637,0.365785070759025,3189]
["Q12893","Transmembrane protein 115 [OS=Homo sapiens]",15,4,8,4,351,38.2,8.16,28.67,"transport;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","TMEM115","ENSG00000126062","","COPI-mediated anterograde transport","",412.9,411.8,407.7,405.9,346.6,449.4,1.0253764872285547,0.03615372097961286,0.7504227797382292,0.12469399104096747,0.8310363783495027,0.08037996469886313,6600]
["Q12907","Vesicular integral-membrane protein VIP36 [OS=Homo sapiens]",42,13,93,13,356,40.2,6.95,303.48,"cell organization and biogenesis;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","LMAN2","ENSG00000169223","Protein processing in endoplasmic reticulum","COPII-mediated vesicle transport; Cargo concentration in the ER","",13591.8,14288.5,14304.3,12068.5,12275,12963.1,1.1307543437354248,0.1772855380197506,0.0105037602235395,1.9786552007401916,0.11174961204345009,0.9517539759157692,687]
["Q12931","heat shock protein 75 kDa, mitochondrial [OS=Homo sapiens]",50,30,194,29,704,80.1,8.21,663.74,"other biological processes","other membranes;mitochondrion;nucleus","signal transduction activity or receptor binding;other molecular function","TRAP1","ENSG00000126602","Parkinson disease; Pathways of neurodegeneration","Respiratory electron transport","TNF-alpha signaling pathway; TGF-beta signaling pathway",17039.4,17026.1,17306.6,15818.5,15338.3,15506.9,1.1009007001159359,0.13868434545903152,7.263787023010775E-4,3.138836897979148,0.034474687890380364,1.4624996569316377,154]
["Q12979","active breakpoint cluster region-related protein [OS=Homo sapiens]",17,15,38,15,859,97.5,6.55,106.76,"signal transduction;other biological processes","cytosol;other cell component","enzyme regulator activity","ABR","ENSG00000159842; ENSG00000276016; ENSG00000278741","","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC3 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOC GTPase cycle; RAC2 GTPase cycle; RHOB GTPase cycle","",4809.8,5000.3,4902.9,4838.1,4608.3,3004.6,1.181672154847,0.24082982723911925,0.26297174696303754,0.5800909085336753,0.4985889749812818,0.30225732903667807,3855]
["Q12982","BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 [OS=Homo sapiens]",13,5,6,5,314,36,4.81,16.43,"other metabolic processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","BNIP2","ENSG00000140299","","Myogenesis","Acute viral myocarditis",838,915.1,872.5,896.2,992.8,623.9,1.0448485813203867,0.06329388316138472,0.7555681013258543,0.12172638546511949,0.8348370752215675,0.07839827210466631,6615]
["Q13033-2","Isoform Alpha of Striatin-3 [OS=Homo sapiens]",11,6,9,1,713,77.7,5.26,23.04,"","","","STRN3","","","","",34.4,35.9,34.6,29.7,41.2,39.5,0.9501811594202898,-0.07372549420090155,0.6386867172871225,0.19471211573318714,0.7525650840966593,0.1234559350141806,6203]
["Q13085-1","Acetyl-CoA carboxylase 1 [OS=Homo sapiens]",18,34,70,29,2346,265.4,6.37,209.21,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","ACACA","ENSG00000275176; ENSG00000278540","Fatty acid biosynthesis; Pyruvate metabolism; Propanoate metabolism; Metabolic pathways; Fatty acid metabolism; AMPK signaling pathway; Insulin signaling pathway; Glucagon signaling pathway; Alcoholic liver disease","Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency; ChREBP activates metabolic gene expression; Carnitine metabolism; Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis","AMP-activated protein kinase (AMPK) signaling; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; Corticotropin-releasing hormone signaling pathway; Mesodermal commitment pathway; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin and adiponectin; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Mitochondrial fatty acid synthesis pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; 7q11.23 copy number variation syndrome",6688.7,6557,6895.3,6580.9,6338.7,7368.5,0.9927494442554996,-0.010498446762961678,0.8877499709898811,0.051709333218332015,0.9229821533378436,0.03480669635418302,7030]
["Q13107-1","Ubiquitin carboxyl-terminal hydrolase 4 [OS=Homo sapiens]",25,18,30,17,963,108.5,5.71,84.23,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","USP4","ENSG00000114316","","Ub-specific processing proteases; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; TNFR1-induced proapoptotic signaling","",2395,2270.7,2392,2510.5,2349.7,2009,1.027441332323997,0.03905601728245649,0.7030950651685187,0.1529859502478382,0.7989617275057063,0.09747402410426013,6432]
["Q13144","Translation initiation factor eIF-2B subunit epsilon [OS=Homo sapiens]",25,14,54,14,721,80.3,5.08,172.66,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;translational apparatus;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","EIF2B5","ENSG00000145191","Herpes simplex virus 1 infection","Recycling of eIF2:GDP","Translation factors; MicroRNAs in cardiomyocyte hypertrophy",4770.6,4921.9,4963.5,4725.6,4582.1,6262.7,0.9412731850177257,-0.08731459884978916,0.6032880789235032,0.2194752563326795,0.7264304067301293,0.13880598552396417,6070]
["Q13164-1","Mitogen-activated protein kinase 7 [OS=Homo sapiens]",8,4,10,4,816,88.3,5.88,27.2,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","MAPK7","ENSG00000166484","MAPK signaling pathway; Gap junction; IL-17 signaling pathway; Neurotrophin signaling pathway; GnRH signaling pathway; Oxytocin signaling pathway; MicroRNAs in cancer; Fluid shear stress and atherosclerosis","Senescence-Associated Secretory Phenotype (SASP); Gastrin-CREB signalling pathway via PKC and MAPK; ERKs are inactivated; RET signaling; Signalling to ERK5","MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Brain-derived neurotrophic factor (BDNF) signaling pathway; S1P receptor signal transduction; Cardiac hypertrophic response; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Osteoblast differentiation and related diseases; Insulin signaling; Malignant pleural mesothelioma",248.8,220.7,243.9,256.1,273.9,513.5,0.6836607570675611,-0.5486474795803853,0.2577166629667768,0.5888575007328678,0.49413722183215414,0.30615243081518373,3812]
["Q13188","serine/threonine-protein kinase 3 [OS=Homo sapiens]",22,10,38,6,491,56.3,5.24,113.73,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","STK3","ENSG00000104375","MAPK signaling pathway; Hippo signaling pathway; Hippo signaling pathway","Signaling by Hippo","MAPK signaling pathway; Transcription co-factors SKI and SKIL protein partners; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Overview of leukocyte-intrinsic Hippo pathway functions; Malignant pleural mesothelioma",1094.4,1014.8,1099,957.6,1044.5,679.1,1.1965537818887064,0.2588852436130182,0.19675469289438322,0.7060749002709118,0.43737227809155926,0.35914874725495166,3288]
["Q13232","Nucleoside diphosphate kinase 3 [OS=Homo sapiens]",37,6,24,6,169,19,7.84,62.61,"other metabolic processes;other biological processes","cytosol","kinase activity;other molecular function","NME3","ENSG00000103024","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors","Interconversion of nucleotide di- and triphosphates","Pyrimidine metabolism",3231.9,3345.1,3223.7,3073,3146.3,3209.7,1.0394209354120267,0.05578002233563423,0.08987697692103472,1.0463515438251498,0.30682429907325676,0.5131102492356151,2141]
["Q13243-1","Serine/arginine-rich splicing factor 5 [OS=Homo sapiens]",30,9,51,8,272,31.2,11.59,160.37,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","SFRS5; SRSF5","ENSCANG00000030560; ENSCCAG00000029002; ENSCJAG00000014884; ENSCSAG00000013041; ENSG00000100650; ENSGGOG00000016462; ENSMFAG00000002393; ENSMMUG00000022407; ENSMNEG00000030872; ENSNLEG00000001615; ENSPPAG00000029921; ENSPPYG00000005945; ENSPTRG00000006488; ENSRBIG00000013003; ENSRROG00000043407; ENSSBOG00000030784","Spliceosome; Herpes simplex virus 1 infection","mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","mRNA processing; mRNA Processing",5878.5,5796.7,5813.3,5863.6,6091,6165.1,0.9651649861752677,-0.05115251583137716,0.08897905154019436,1.050712227864837,0.30575829229303275,0.5146217558835929,2127]
["Q13303-2","Isoform 2 of Voltage-gated potassium channel subunit beta-2 [OS=Homo sapiens]",48,13,60,13,353,39.3,8.62,152.58,"","","","KCNAB2","","","","",6241.8,6425.6,6531.8,5938.5,5925.7,5065.1,1.1340811492501164,0.1815238761108381,0.06590125721712657,1.1811063001669542,0.2655304790518071,0.5758856210070578,1814]
["Q13325","Interferon-induced protein with tetratricopeptide repeats 5 [OS=Homo sapiens]",21,9,16,9,482,55.8,7.4,47.35,"stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity","IFIT5","ENSG00000152778","","Interferon alpha/beta signaling","",1384.8,1346.4,1417.6,1588.6,1413.3,981.1,1.0416269143861412,0.05883863160174637,0.7761576227222949,0.11005007290788277,0.8478457726015923,0.07168314090334064,6691]
["Q13395","Probable methyltransferase TARBP1 [OS=Homo sapiens]",2,3,3,3,1621,181.6,7.05,7.9,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","TARBP1","ENSG00000059588","","","",275.4,255.9,285.7,285.2,281.5,464.3,0.7924345295829291,-0.335636349222425,0.30686692428599815,0.5130499195648991,0.5346580094413255,0.2719239228456452,4195]
["Q13423","NAD(P) transhydrogenase, mitochondrial [OS=Homo sapiens]",42,39,277,39,1086,113.8,8.09,854.59,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","NNT","ENSG00000112992","Nicotinate and nicotinamide metabolism; Metabolic pathways","Citric acid cycle (TCA cycle)","",40791.9,42433.9,42250.4,34477,35727.9,32138,1.2260371750263088,0.29400272406376243,0.002774086808238885,2.556879952870068,0.06034464428993455,1.219361268375939,336]
["Q13433-1","Zinc transporter ZIP6 [OS=Homo sapiens]",3,2,3,2,755,85,6.95,8.51,"transport;other biological processes","plasma membrane;other membranes;ER/Golgi","transporter activity","SLC39A6","ENSG00000141424","Alzheimer disease; Parkinson disease","Zinc influx into cells by the SLC39 gene family","Nuclear receptors meta-pathway; NRF2 pathway; Zinc homeostasis",534.5,524,571.8,508.5,501.1,549.7,1.0455332521003011,0.06423894607606753,0.3217760621484835,0.49244626745734277,0.5421533513700474,0.2658778532515443,4338]
["Q13439-1","Golgin subfamily A member 4 [OS=Homo sapiens]",23,44,60,42,2230,261,5.39,181.85,"cell organization and biogenesis;transport;developmental processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","GOLGA4","ENSG00000144674","","Retrograde transport at the Trans-Golgi-Network; Signaling by membrane-tethered fusions of PDGFRA or PDGFRB","",4544.4,4090.8,4434.8,5062.7,4901,5392,0.851149735928678,-0.23251513891147935,0.018594729048225397,1.7306101455501228,0.14629588225347623,0.8347678976597916,929]
["Q13464","Rho-associated protein kinase 1 [OS=Homo sapiens]",36,47,75,41,1354,158.1,5.9,189.39,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function","ROCK1","ENSG00000067900","cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Vascular smooth muscle contraction; TGF-beta signaling pathway; Axon guidance; Focal adhesion; Tight junction; Platelet activation; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Pathogenic Escherichia coli infection; Shigellosis; Yersinia infection; Human cytomegalovirus infection; Pathways in cancer; Proteoglycans in cancer; MicroRNAs in cancer","Neutrophil degranulation; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHOB GTPase cycle; Sema4D induced cell migration and growth-cone collapse; RND3 GTPase cycle; RHOBTB1 GTPase cycle; EPHB-mediated forward signaling; Potential therapeutics for SARS; VEGFA-VEGFR2 Pathway; Apoptotic cleavage of cellular proteins; EPHA-mediated growth cone collapse; RHO GTPases Activate ROCKs; RHOH GTPase cycle","Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Microtubule cytoskeleton regulation; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Focal adhesion; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; EGF/EGFR signaling pathway; Gastrin signaling pathway; mBDNF and proBDNF regulation of GABA neurotransmission; MAP3K1 role in promoting and blocking gonadal determination; Airway smooth muscle cell contraction; RAS and bradykinin pathways in COVID-19; Regulation of actin cytoskeleton; G13 signaling pathway",8219.6,7616.8,8259.3,8906.5,8483,7989,0.9494532773804599,-0.0748310878248783,0.27317828322950455,0.5635538285939695,0.507797576837347,0.2943093758700946,3932]
["Q13480-1","GRB2-associated-binding protein 1 [OS=Homo sapiens]",26,13,23,13,694,76.6,5.96,75.05,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;other cell component","","GAB1","ENSG00000109458","EGFR tyrosine kinase inhibitor resistance; ErbB signaling pathway; Ras signaling pathway; Phospholipase D signaling pathway; Neurotrophin signaling pathway; Bacterial invasion of epithelial cells; Proteoglycans in cancer; Renal cell carcinoma; Hepatocellular carcinoma; Gastric cancer","Signaling by ERBB2 KD Mutants; Signaling by FGFR1 in disease; Signaling by FGFR2 in disease; Signaling by FGFR3 point mutants in cancer; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FGFR4 in disease; Signaling by FGFR3 fusions in cancer; RET signaling; PIP3 activates AKT signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Constitutive Signaling by Aberrant PI3K in Cancer; MET activates RAP1 and RAC1; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); PI3K Cascade; PI3K events in ERBB2 signaling; GAB1 signalosome; PI-3K cascade:FGFR1; PI-3K cascade:FGFR2; PI-3K cascade:FGFR3; PI-3K cascade:FGFR4; MET activates PI3K/AKT signaling; MET activates PTPN11; MET receptor recycling; Activated NTRK2 signals through PI3K","Glioblastoma signaling pathways; B cell receptor signaling pathway; Alpha 6 beta 4 signaling pathway; Hepatocyte growth factor receptor signaling; IL-6 signaling pathway; BDNF-TrkB signaling; VEGFA-VEGFR2 signaling pathway; Embryonic stem cell pluripotency pathways; Ras signaling; EGF/EGFR signaling pathway; Fragile X syndrome; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; ErbB signaling pathway",2138.4,2106.5,2143.2,2221.9,2218,2830.7,0.8786207465683711,-0.18668752919453577,0.22259765893019762,0.6524794074723047,0.46418439061934785,0.3333094678910093,3505]
["Q13510","Acid ceramidase [OS=Homo sapiens]",39,14,67,14,395,44.6,7.62,179.54,"other metabolic processes;developmental processes;other biological processes","non-structural extracellular;nucleus;other cytoplasmic organelle;other cell component","other molecular function","ASAH1","ENSG00000104763","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway; Lysosome","Neutrophil degranulation; Glycosphingolipid metabolism","Sphingolipid pathway; S1P receptor signal transduction; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway; Sphingolipid metabolism in senescence",7597.9,7501.6,7398.8,6810.9,7121.3,6359.6,1.1087385052090006,0.14891914753519173,0.03230986429914313,1.4906648660076451,0.1881695602887945,0.7254506299407291,1255]
["Q13555-8","Isoform 8 of Calcium/calmodulin-dependent protein kinase type II subunit gamma [OS=Homo sapiens]",27,11,24,9,556,62.1,7.42,70.38,"protein metabolism;other metabolic processes;other biological processes","other cell component","kinase activity;other molecular function","CAMK2G; LOC111145432","ENSCATG00000041481; ENSECAG00000000031; ENSFCAG00000018407; ENSG00000148660; ENSLCNG00005022562; ENSMPUG00000003376; ENSPANG00000022457; ENSPTRG00000002643","ErbB signaling pathway; Calcium signaling pathway; cAMP signaling pathway; HIF-1 signaling pathway; Oocyte meiosis; Necroptosis; Adrenergic signaling in cardiomyocytes; Wnt signaling pathway; Axon guidance; Circadian entrainment; Long-term potentiation; Neurotrophin signaling pathway; Cholinergic synapse; Dopaminergic synapse; Olfactory transduction; Inflammatory mediator regulation of TRP channels; Insulin secretion; GnRH signaling pathway; Melanogenesis; Oxytocin signaling pathway; Glucagon signaling pathway; Aldosterone synthesis and secretion; Cushing syndrome; Gastric acid secretion; Parkinson disease; Pathways of neurodegeneration; Amphetamine addiction; Tuberculosis; Pathways in cancer; Proteoglycans in cancer; Glioma; Diabetic cardiomyopathy; Lipid and atherosclerosis","","Energy metabolism; Myometrial relaxation and contraction pathways; NO/cGMP/PKG mediated neuroprotection; Splicing factor NOVA regulated synaptic proteins; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Disruption of postsynaptic signaling by CNV; Neuroinflammation and glutamatergic signaling; Calcium regulation in cardiac cells; ErbB signaling pathway; Calcium regulation in cardiac cells",2180.6,2111,2316.9,1871.5,1771.1,1723.9,1.2314357588744993,0.3003413677714272,0.005133734227271773,2.2895666184493417,0.07916131533149659,1.101486998239454,474]
["Q13564-1","NEDD8-activating enzyme E1 regulatory subunit [OS=Homo sapiens]",54,17,64,17,534,60.2,5.4,215.51,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","NAE1","ENSG00000159593","Alzheimer disease","Neddylation","Alzheimer's disease and miRNA effects; Hijack of ubiquitination by SARS-CoV-2; Alzheimer's disease",5721.8,5799,5765.2,5694.2,5645.9,6678.4,0.9593473374587229,-0.05987484866922542,0.5090247690409613,0.2932610844685671,0.6612979091575517,0.17960285041377624,5626]
["Q13576-1","Ras GTPase-activating-like protein IQGAP2 [OS=Homo sapiens]",47,62,224,61,1575,180.5,5.64,738.75,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","IQGAP2","ENSG00000145703","Regulation of actin cytoskeleton","CDC42 GTPase cycle; RAC1 GTPase cycle; Neutrophil degranulation; RHOG GTPase cycle; RHO GTPases activate IQGAPs","Ciliary landscape; G13 signaling pathway",23826.5,23847.4,24536.9,21279.9,21419.5,18646.7,1.1771049830388565,0.23524299646406552,0.017729247792549283,1.7513096900321952,0.14318571504501956,0.8441003073534254,905]
["Q13614-1","Myotubularin-related protein 2 [OS=Homo sapiens]",8,3,3,3,643,73.3,7.4,11.38,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MTMR2","ENSG00000087053; ENSGGOG00000010339; ENSPPAG00000042525; ENSPTRG00000004195","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; Synthesis of PIPs at the ER membrane","Intracellular trafficking proteins involved in CMT neuropathy",77.9,80.5,89.5,86.8,87,158,0.7471368294153105,-0.420555614869141,0.3079421201135916,0.5115309045302776,0.5348738013094679,0.2717486737919873,4208]
["Q13617-1","Cullin-2 [OS=Homo sapiens]",37,25,81,25,745,86.9,6.92,223.45,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction","cytosol;nucleus;other cell component","other molecular function","CUL2","ENSCANG00000032700; ENSCATG00000031722; ENSCCAG00000022671; ENSG00000108094; ENSMFAG00000044478; ENSMMUG00000002469; ENSMNEG00000040111; ENSPANG00000022742; ENSPPYG00000019905","HIF-1 signaling pathway; Ubiquitin mediated proteolysis; Pathways in cancer; Renal cell carcinoma","Antigen processing: Ubiquitination & Proteasome degradation; Regulation of expression of SLITs and ROBOs; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Neddylation","Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2",9127.2,9207.8,9672.1,9142.9,8258.9,7409.4,1.1288087637840973,0.17480109380860162,0.11404147802114897,0.9429371627036026,0.3427340307798429,0.465042771420327,2432]
["Q13636","ras-related protein rab-31 [OS=Homo sapiens]",8,1,1,1,194,21.6,7.06,4.1,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","RAB31","ENSG00000168461","Endocytosis","Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation","",26.2,24.8,25.8,22.4,22.6,33.1,0.9833546734955185,-0.02421623742082319,0.908943970764397,0.04146288678662099,0.9392720885503998,0.027208582985095153,7073]
["Q13642-1","Isoform 1 of Four and a half LIM domains protein 1 [OS=Homo sapiens]",58,14,55,14,280,31.9,8.32,169.98,"","","","FHL1","","","","",11221.4,11250.5,11076.5,10559.4,10081.4,9983.4,1.0954865759758625,0.13157180574145258,0.006324545962458319,2.1989706469231685,0.08941219814237496,1.0486032281331379,517]
["Q13813","Spectrin alpha chain, non-erythrocytic 1 [OS=Homo sapiens]",71,168,1089,1,2472,284.4,5.35,3590.42,"cell organization and biogenesis","non-structural extracellular;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SPTAN1","ENSG00000197694","Apoptosis","Neutrophil degranulation; COPI-mediated anterograde transport; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Interaction between L1 and Ankyrins; RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Caspase-mediated cleavage of cytoskeletal proteins","Fas ligand pathway and stress induction of heat shock proteins",887.4,810.4,880.8,902.9,931,549.1,1.0820814099874108,0.11380904386607789,0.6303736002607053,0.20040198317899569,0.7469845402570517,0.1266883863379233,6168]
["Q13868","Exosome complex component Rrp4 [OS=Homo sapiens]",25,6,17,6,293,32.8,7.5,62.26,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","EXOSC2","ENSG00000130713","RNA degradation","ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; Major pathway of rRNA processing in the nucleolus and cytosol; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease","Ciliary landscape",1272.6,1253.2,1458.4,1268,1095.9,764.6,1.2735176602205531,0.34881896600076473,0.15222596319362464,0.8175112693125085,0.39025589792430815,0.40865052473799546,2851]
["Q13948","Protein CASP [OS=Homo sapiens]",35,22,48,5,678,77.4,5.44,118.09,"transport","other membranes;ER/Golgi;nucleus","","CUX1","ENSG00000257923","","Intra-Golgi traffic","",516.2,503.6,478.7,496.7,533.6,349.8,1.0857908847184987,0.11874627751674938,0.528205011996623,0.27719748220491897,0.6717679541818892,0.17278071745464363,5747]
["Q13951-2","Isoform 2 of Core-binding factor subunit beta [OS=Homo sapiens]",29,5,16,5,187,22,5.58,50.61,"","","","CBFB","","","","",1420.1,1288.3,1312.4,1534.1,1666.9,1018.2,0.9529768676526357,-0.06948689998390464,0.759738455100577,0.11933589068758327,0.8374194493032902,0.0770569567156192,6631]
["Q14061","cytochrome C oxidase copper chaperone [OS=Homo sapiens]",32,2,7,2,63,6.9,7.24,22.8,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","mitochondrion;other cell component","other molecular function","COX17","ENSG00000138495","Oxidative phosphorylation; Metabolic pathways; Thermogenesis","Mitochondrial protein import","Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis; IL-18 signaling pathway; Mitochondrial complex IV assembly",687.7,634,576,544.4,616.7,614.4,1.0688256829062237,0.09602657998698202,0.3665274939091904,0.4358934425639219,0.5668534602163082,0.24652919797629913,4726]
["Q14108-1","Lysosome membrane protein 2 [OS=Homo sapiens]",27,12,78,12,478,54.3,5.14,208.67,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SCARB2","ENSG00000138760","Lysosome","Cargo recognition for clathrin-mediated endocytosis","Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome",9747.6,10262.6,10006.8,8424.2,8813.4,6991.2,1.2388975104008453,0.30905684336851247,0.028215537141158816,1.5495116776207412,0.17839737107675588,0.7486115498212784,1156]
["Q14141-1","Septin-6 [OS=Homo sapiens]",47,19,85,9,434,49.7,6.67,271.65,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component","other molecular function","SEPTIN6","ENSCANG00000016430; ENSCATG00000036060; ENSG00000125354; ENSMLEG00000030428; ENSMMUG00000017669; ENSMNEG00000026932; ENSPANG00000000899; ENSPPAG00000040865; ENSRBIG00000044672; ENSRROG00000038667","Bacterial invasion of epithelial cells; Shigellosis","","",12771.5,12860.4,11918.9,13888.8,13526.6,11628.1,0.9617682840933831,-0.056238743154543185,0.5496904285502676,0.2598818250935611,0.6873716582162371,0.16280837870744705,5845]
["Q14147","Probable ATP-dependent RNA helicase DHX34 [OS=Homo sapiens]",9,6,8,6,1143,128,7.56,16.79,"RNA metabolism OR transcription;other metabolic processes;other biological processes","","other molecular function","DHX34","ENSG00000134815","","","",434.7,487.5,469.8,500,514.5,436.4,{"$f":"AVERAGE(S2946:U2946)/AVERAGE(V2946:X2946)","v":0.9594045075470397},{"$f":"LOG(Y2946,2)","v":-0.05978887715275148},{"$f":"TTEST(V2946:X2946,S2946:U2946,2,2)","v":0.529667635285803},0.27599656330417466,{"$f":"AA2946*7309/AE2946","v":0.6726917022248364},0.17218392938601235,5755]
["Q14164","Inhibitor of nuclear factor kappa-B kinase subunit epsilon [OS=Homo sapiens]",6,4,5,3,716,80.4,7.84,15.39,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","IKBKE","ENSG00000263528","Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Alcoholic liver disease; Hepatitis C; Hepatitis B; Measles; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease; Chemical carcinogenesis; Lipid and atherosclerosis","Negative regulators of DDX58/IFIH1 signaling; SUMOylation of immune response proteins; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; TICAM1-dependent activation of IRF3/IRF7","Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Cardiac hypertrophic response; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Ebola virus pathway in host; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; STING pathway in Kawasaki-like disease and COVID-19; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Toll-like receptor signaling pathway",345.2,351.3,358.4,353.5,377.3,376.7,0.9525056433408579,-0.07020045467431482,0.11453474758622081,0.941062736943173,0.3433693478702575,0.46423847634156323,2438]
["Q14197","Peptidyl-tRNA hydrolase ICT1, mitochondrial [OS=Homo sapiens]",8,2,3,2,206,23.6,10.07,7.23,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL58","ENSG00000167862","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",611.6,558,626.9,678.9,597.1,447.5,1.0423556715984914,0.05984763663489466,0.7487080082873114,0.12568752157158916,0.8300177206995237,0.08091263543131881,6593]
["Q14204","Cytoplasmic dynein 1 heavy chain 1 [OS=Homo sapiens]",44,185,631,185,4646,532.1,6.4,1919.08,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","DYNC1H1","ENSG00000197102","Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection","Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; COPI-mediated anterograde transport; Neutrophil degranulation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; HCMV Early Events; COPI-independent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Aggrephagy","Ciliary landscape; Intraflagellar transport proteins binding to dynein",68670.3,68702.6,69853.8,64816.8,62724.8,66577,1.067526244265104,0.09427153776680017,0.02075392900609029,1.682899673210358,0.15322269404597366,0.814676905923935,990]
["Q14247-1","Src substrate cortactin [OS=Homo sapiens]",4,2,2,2,550,61.5,5.4,3.99,"cell adhesion;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","CTTN","ENSG00000085733; ENSG00000288401","Tight junction; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Proteoglycans in cancer","Clathrin-mediated endocytosis; RHO GTPases activate PAKs","Pathogenic Escherichia coli infection; Hepatitis C and hepatocellular carcinoma",113.5,110.7,112.6,104,124.9,147.4,0.8950305607228274,-0.1599911510014854,0.35360967823159856,0.4514758569365186,0.5616108514112894,0.2505645093851702,4602]
["Q14331","Protein FRG1 [OS=Homo sapiens]",24,6,20,6,258,29.2,9.01,52.02,"RNA metabolism OR transcription;other metabolic processes;developmental processes","cytoskeleton;nucleus","cytoskeletal activity","FRG1","ENSG00000109536; ENSG00000275145; ENSG00000283153; ENSG00000283630","","","",2995.4,3049.4,3025.5,3293.6,3663.9,2507.4,0.9583091210683683,-0.06143699477461163,0.7195901061003197,0.142914816554356,0.8108979471919884,0.09103379900733703,6486]
["Q14376","UDP-glucose 4-epimerase [OS=Homo sapiens]",40,12,41,12,348,38.3,6.73,131.26,"other metabolic processes","cytosol","other molecular function","GALE","ENSG00000117308","Galactose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars","Galactose catabolism; Defective GALE can cause Epimerase-deficiency galactosemia (EDG)","",4078.5,4128.6,4184.9,3726.5,3343.9,2820,1.2529321362128936,0.3253082746752755,0.03444031214104885,1.4629329210824717,0.19274444214312864,0.715018136137554,1306]
["Q14498-1","RNA-binding protein 39 [OS=Homo sapiens]",31,13,35,13,530,59.3,10.1,115.7,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","LOC101348913; LOC111141906; LOC112827340; Rbm39; RBM39","ENSAMEG00000009940; ENSANAG00000024610; ENSBIXG00000021585; ENSBIXG00005010311; ENSBMUG00000009739; ENSCAFG00000008327; ENSCCAG00000031689; ENSDLEG00000014321; ENSECAG00000013423; ENSFCAG00000003233; ENSG00000131051; ENSGGOG00000003950; ENSHGLG00000017871; ENSLAFG00000010346; ENSLCNG00005002645; ENSMMUG00000031284; ENSMNEG00000040217; ENSMPUG00000017786; ENSOCUG00000007050; ENSPCOG00000027976; ENSPCTG00005007206; ENSPPAG00000029710; ENSPPYG00000010963; ENSPTRG00000049720; ENSRBIG00000044413; ENSRFEG00010016851; ENSRROG00000037484; ENSSSCG00000007309; ENSSSCG00070008152; ENSSSUG00005008586; ENSTTRG00000017039; ENSUAMG00000010443; ENSUMAG00000004302; ENSVVUG00000001290","","","mRNA Processing; VEGFA-VEGFR2 signaling pathway; mRNA processing; mRNA Processing",5578.1,5517.9,5538.6,5212.6,6166.1,4166.8,1.070058859477019,0.09769015544896127,0.563781934136248,0.24888884480113926,0.6974749757281377,0.1564713695570781,5908]
["Q14554","Protein disulfide-isomerase A5 [OS=Homo sapiens]",40,16,47,16,519,59.6,7.91,140.49,"other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","PDIA5","ENSG00000065485","","XBP1(S) activates chaperone genes","",4309.2,4393.9,4583.3,4043,3801.8,3816.4,1.139368161081192,0.18823399668888768,0.008558334415503611,2.0676107475353844,0.10305249792902124,0.9869414767266692,607]
["Q14596-1","Next to BRCA1 gene 1 protein [OS=Homo sapiens]",7,4,4,4,966,107.3,5.12,7.5,"other metabolic processes;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","NBR1","ENSG00000188554","Mitophagy","Pexophagy","",180.1,159.2,167.7,229.7,259.2,444.7,0.5430591259640102,-0.8808188138166455,0.10310864769890611,0.9867049090092186,0.3278038738718159,0.4843859183945246,2299]
["Q14671-3","Isoform 3 of Pumilio homolog 1 [OS=Homo sapiens]",12,12,15,8,1188,126.6,6.84,37.44,"","","","PUM1","","","","",1027,1060.3,1040.3,1799.8,1716.3,1951.3,{"$f":"AVERAGE(S3010:U3010)/AVERAGE(V3010:X3010)","v":0.5720452134469768},{"$f":"LOG(Y3010,2)","v":-0.8057989153000163},{"$f":"TTEST(V3010:X3010,S3010:U3010,2,2)","v":3.5821939723051119E-4},3.4458509012282144,{"$f":"AA3010*7309/AE3010","v":0.024935481660550537},1.6031822384141796,105]
["Q14677-1","Clathrin interactor 1 [OS=Homo sapiens]",31,20,83,20,625,68.2,6.42,237.51,"cell organization and biogenesis;transport","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","CLINT1","ENSG00000113282","","Golgi Associated Vesicle Biogenesis","",9339.3,9557.1,9352.6,10207.1,10175.5,16984.9,0.75597778818492,-0.4035842484651213,0.25083973234097606,0.6006036713112115,0.48708491064829806,0.3123953241824579,3764]
["Q14692","ribosome biogenesis protein BMS1 homolog [OS=Homo sapiens]",16,16,27,16,1282,145.7,6.44,68.05,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","BMS1","ENSG00000165733","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",1435.1,1475,1482.6,3833.4,3706.4,4388.9,0.36824633027907483,-1.4412569465836307,2.8031475795706282E-4,3.552354036986072,0.025294081060594716,1.596981093980749,81]
["Q14764","major vault protein [OS=Homo sapiens]",62,42,250,42,893,99.3,5.48,824.62,"transport;signal transduction;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","MVP","ENSG00000013364","","Neutrophil degranulation","16p11.2 proximal deletion syndrome",27304.9,27692.8,28198.2,28437.7,28053.5,26598.7,1.0012757266526977,1.839311535297103E-3,0.9570715911429654,0.01905557478799322,0.9711559433102782,0.01271102768071001,7203]
["Q14790-4","Isoform 4 of Caspase-8 [OS=Homo sapiens]",50,20,54,9,496,57.7,5.43,187.15,"","","","CASP8","","","","",5181.3,5461.4,5300.3,5193.2,5170.8,4414.9,1.0787677026030353,0.10938423425758578,0.22170915224440016,0.6542163786617913,0.46352179455215126,0.3339298407401838,3496]
["Q14849-1","StAR-related lipid transfer protein 3 [OS=Homo sapiens]",13,4,8,4,445,50.5,8.37,16.7,"cell organization and biogenesis;other metabolic processes;transport","other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","STARD3","ENSG00000131748","Cholesterol metabolism","Pregnenolone biosynthesis","",314.3,312.4,350.2,281.3,258.6,314.9,1.142840430510061,0.19262398082041618,0.11755515728962078,0.9297583130869606,0.34673553052051587,0.4600016532430322,2478]
["Q14966-1","Zinc finger protein 638 [OS=Homo sapiens]",19,29,48,29,1978,220.5,6.38,116.6,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF638","ENSG00000075292","","Transcriptional regulation of white adipocyte differentiation","",3840.2,3759.2,3940.6,4877,5079.3,5580.3,0.7427622517153046,-0.42902759766324655,3.4804173174993605E-3,2.4583686790933394,0.0683827155204377,1.1650536570912637,372]
["Q14999","Cullin-7 [OS=Homo sapiens]",2,3,3,1,1698,191,5.87,8.39,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","CUL7","ENSG00000044090","Ubiquitin mediated proteolysis","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; XBP1(S) activates chaperone genes","",34.6,29,32.1,45.8,42.9,94.5,0.5223799126637555,-0.9368286736109183,0.15785340589840885,0.801746043186225,0.39552641196827915,0.40282451042398465,2917]
["Q15006","ER membrane protein complex subunit 2 [OS=Homo sapiens]",34,8,35,8,297,34.8,6.57,87.91,"cell organization and biogenesis","other membranes;ER/Golgi;other cell component","","EMC2","ENSG00000104412","","","",2030.5,2043.1,2076.2,1963.4,1900.8,1417.7,1.1643158711827182,0.21948250495435462,0.16970270263254678,0.7703112411881855,0.410578303059015,0.38660400457749305,3021]
["Q15011-3","Isoform 3 of Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein [OS=Homo sapiens]",22,4,10,4,232,26.2,5.77,25.63,"","","","HERPUD1","","","","",715,730.9,692.5,1239.3,1190.9,1768.9,0.5092519825676931,-0.9735484031326027,0.02076796555811353,1.6826060451192106,0.15317160470661131,0.814821737720513,991]
["Q15022","Polycomb protein suz12 [OS=Homo sapiens]",9,5,9,5,739,83,8.81,24.37,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","SUZ12","ENSG00000178691","","HCMV Early Events; Oxidative Stress Induced Senescence; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PRC2 methylates histones and DNA; Defective pyroptosis; PKMTs methylate histone lysines; SUMOylation of chromatin organization proteins; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6","Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Malignant pleural mesothelioma",1239.8,1206,1211.5,1606.7,1532.8,1417.3,0.8026027036516854,-0.3172420788911721,5.906475478272227E-3,2.2286715947434397,0.08565561363232481,1.0672441693049919,504]
["Q15042-1","Rab3 GTPase-activating protein catalytic subunit [OS=Homo sapiens]",39,31,82,31,981,110.5,5.55,233.69,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","RAB3GAP1","ENSG00000115839","","RAB GEFs exchange GTP for GDP on RABs; COPI-independent Golgi-to-ER retrograde traffic","",7235.1,7373.1,7649.1,7642.9,7442.1,7011.4,1.00728172915045,0.010467250775207684,0.8213806850762236,0.08545551388002974,0.8788568917028428,0.05608183733086198,6831]
["Q15043","Zinc transporter ZIP14 [OS=Homo sapiens]",9,4,5,4,492,54.2,5.33,18.12,"other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle","transporter activity","SLC39A14","ENSG00000104635","Ferroptosis; Alzheimer disease; Parkinson disease","Zinc influx into cells by the SLC39 gene family","Nuclear receptors meta-pathway; NRF2 pathway; Zinc homeostasis; Ferroptosis",545.7,572.3,526.8,557,597.2,630.6,0.9215598386373822,-0.11785024905026263,0.1357881239620554,0.8671382118175637,0.3710188403882852,0.430604036290838,2675]
["Q15056-1","Eukaryotic translation initiation factor 4H [OS=Homo sapiens]",38,8,31,8,248,27.4,7.23,82.22,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","translation activity;nucleic acid binding activity","EIF4H","ENSG00000106682; ENSPTRG00000019287","","L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Ribosomal scanning and start codon recognition","Translation factors; 7q11.23 copy number variation syndrome",3297.9,2827.5,3197.7,3574,2889.1,2917.6,0.9938597332821643,-0.008885841065161463,0.9458281333711506,0.02418777217073698,0.9640298182693822,0.015909532788481878,7171]
["Q15061","WD repeat-containing protein 43 [OS=Homo sapiens]",30,17,45,17,677,74.8,5.57,106.65,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","WDR43","ENSG00000163811","Ribosome biogenesis in eukaryotes","rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol","",4046.4,4027.8,4044.6,4643.9,4496.7,5180.7,0.8462080956337764,-0.2409156069302378,0.0242163657822665,1.615891032090294,0.16464876046752172,0.7834415344579452,1075]
["Q15102","Platelet-activating factor acetylhydrolase IB subunit gamma [OS=Homo sapiens]",41,8,32,8,231,25.7,6.84,85.33,"other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","other molecular function","PAFAH1B3","ENSG00000079462","Ether lipid metabolism; Metabolic pathways","COPI-independent Golgi-to-ER retrograde traffic","",3819,3754,3654.1,3711.7,3616.1,4676.9,0.935225370063392,-0.09661402818268512,0.49091378128999014,0.3089947758973075,0.6488406559581442,0.18786194531803282,5530]
["Q15126","phosphomevalonate kinase [OS=Homo sapiens]",78,12,44,12,192,22,5.73,115.47,"other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle","kinase activity;other molecular function","PMVK","ENSG00000163344","Terpenoid backbone biosynthesis; Metabolic pathways; Peroxisome","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Cholesterol biosynthesis pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways",5967.3,5754,5547.7,6193.4,5898.1,4596.7,1.0348030344794525,0.049356189732546185,0.7210655193896042,0.14202527145732613,0.8114346237442058,0.09074646498239984,6495]
["Q15154-1","Pericentriolar material 1 protein [OS=Homo sapiens]",31,44,79,44,2024,228.4,5.02,213.04,"","","","","","","","",6290.3,6007.7,6105.4,8225.3,8400.7,8339,0.7371680352493492,-0.43993458005960734,2.337759854534866E-5,4.631200103613422,0.01314360521291949,1.8812854940362858,13]
["Q15185","Prostaglandin E synthase 3 [OS=Homo sapiens]",56,9,100,9,160,18.7,4.54,330.43,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","PTGES3","ENSG00000110958","Arachidonic acid metabolism; Metabolic pathways; Chemical carcinogenesis","HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Estrogen-dependent gene expression; Potential therapeutics for SARS; HSF1 activation; Aryl hydrocarbon receptor signalling; Synthesis of Prostaglandins (PG) and Thromboxanes (TX); Attenuation phase","Aryl hydrocarbon receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway",16104.9,14991.7,14622.6,15081.2,15758,10466.6,1.1068469803272178,0.14645578582111707,0.44087484522494647,0.35568467978935553,0.6112204559463456,0.213802119491336,5272]
["Q15291-1","Retinoblastoma-binding protein 5 [OS=Homo sapiens]",36,14,34,14,538,59.1,5.1,104.98,"protein metabolism;other metabolic processes;stress response;other biological processes","nucleus","nucleic acid binding activity;other molecular function","LOC101350636; RBBP5","ENSANAG00000037817; ENSBIXG00000017360; ENSBIXG00005000379; ENSBTAG00000015946; ENSCANG00000035291; ENSCHIG00000014205; ENSCJAG00000017172; ENSCSAG00000014601; ENSG00000117222; ENSGGOG00000014796; ENSLCNG00005015908; ENSMFAG00000038790; ENSMLEG00000013766; ENSMMUG00000018803; ENSMNEG00000044153; ENSNLEG00000014409; ENSPANG00000015342; ENSPPAG00000004153; ENSPPYG00000000310; ENSPTRG00000001894; ENSRBIG00000028065; ENSRFEG00010013463; ENSRROG00000045061; ENSSSCG00070019803; ENSSSUG00005002678; ENSTSYG00000000255","Cushing syndrome","Formation of the beta-catenin:TCF transactivating complex; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Neddylation; PKMTs methylate histone lysines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Neddylation; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","",2267.3,2366.4,2448,2166.4,2120.1,3806.2,0.8750725962904842,-0.19252538655524942,0.5777635588814343,0.23824985376180624,0.7079419701365303,0.15000233988419398,5965]
["Q15293","Reticulocalbin-1 [OS=Homo sapiens]",48,12,47,12,331,38.9,5,138.54,"","ER/Golgi","other molecular function","RCN1","ENSG00000049449","","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","VEGFA-VEGFR2 signaling pathway",6724.1,5018.9,6272.7,6474.4,3947.3,3689.5,1.276695107432394,0.35241403051104403,0.27280442667757754,0.5641485868526285,0.5077482950309178,0.29435152623907374,3927]
["Q15365","Poly(RC)-binding protein 1 [OS=Homo sapiens]",71,18,365,11,356,37.5,7.09,1369.44,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PCBP1","ENSG00000169564","Spliceosome; Ferroptosis","mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA","Ferroptosis",32402.9,32860.3,32493.4,34548,34031,31053.3,0.9811737759742574,-0.027419419672519242,0.5995026398069525,0.22220890021973025,0.723899685172479,0.14032161224830936,6053]
["Q15369-1","elongin-C [OS=Homo sapiens]",48,4,18,4,112,12.5,4.78,67.62,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","eloc; Eloc; ELOC; eloc.L; LOC101358566; LOC105890220; LOC107550711; LOC107664095; LOC107751353; LOC111156807; LOC113045545; LOC113937395; LOC115195324; Tceb1; TCEB1","ENSACCG00020004765; ENSACUG00000011303; ENSAMEG00000012854; ENSANAG00000026963; ENSBIXG00000018463; ENSBIXG00005018332; ENSBTAG00000050514; ENSCAFG00000008152; ENSCATG00000020385; ENSCATG00000034779; ENSCCAG00000008410; ENSCCAG00000023220; ENSCGRG00001001449; ENSCHIG00000015198; ENSCPOG00000032030; ENSCPRG00005018410; ENSCSAG00000013512; ENSDLEG00000009234; ENSECAG00000000064; ENSEGOG00005000341; ENSELUG00000027740; ENSFCAG00000032823; ENSG00000154582; ENSGAGG00000025908; ENSGALG00000035417; ENSGGOG00000002188; ENSHGLG00000016964; ENSHHUG00000007733; ENSLCNG00005018064; ENSLSDG00000013506; ENSMFAG00000038428; ENSMMDG00005018719; ENSMNEG00000033021; ENSMODG00000006970; ENSMPUG00000010207; ENSMUSG00000079658; ENSOCUG00000032655; ENSOMYG00000017295; ENSOMYG00000030379; ENSPANG00000016947; ENSPCOG00000017567; ENSPCTG00005011391; ENSPMRG00000007569; ENSPPAG00000004063; ENSPPYG00000018678; ENSPSIG00000003701; ENSPTRG00000045560; ENSPTRG00000046987; ENSPTXG00000006319; ENSRBIG00000038767; ENSRFEG00010008700; ENSRNOG00000031730; ENSRROG00000031208; ENSSANG00000000802; ENSSANG00000018252; ENSSBOG00000024839; ENSSFOG00015012880; ENSSFOG00015024826; ENSSGRG00000038413; ENSSGRG00000052876; ENSSHAG00000009970; ENSSHBG00005007386; ENSSRHG00000026121; ENSSRHG00000030142; ENSSSAG00000055027; ENSSSCG00070017636; ENSSSUG00005020214; ENSSTUG00000043851; ENSTMTG00000005512; ENSTSYG00000035894; ENSUAMG00000019951; ENSVURG00010016846; ENSVURG00010021344; ENSXETG00000011828","HIF-1 signaling pathway; Ubiquitin mediated proteolysis; Human immunodeficiency virus 1 infection; Pathways in cancer; Renal cell carcinoma","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Neddylation; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Inactivation of CSF3 (G-CSF) signaling; RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex ; TP53 Regulates Transcription of DNA Repair Genes; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Neddylation; Inactivation of CSF3 (G-CSF) signaling; Neddylation; Antigen processing: Ubiquitination & Proteasome degradation; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Inactivation of CSF3 (G-CSF) signaling; Neddylation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Antigen processing: Ubiquitination & Proteasome degradation; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Inactivation of CSF3 (G-CSF) signaling; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; TP53 Regulates Transcription of DNA Repair Genes; RNA Polymerase II Pre-transcription Events; RNA Polymerase II Transcription Elongation; Inactivation of CSF3 (G-CSF) signaling; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Inactivation of CSF3 (G-CSF) signaling; RNA Polymerase II Pre-transcription Events; Neddylation; Antigen processing: Ubiquitination & Proteasome degradation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA Polymerase II Transcription Elongation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Dual hijack model of Vif in HIV infection; VEGFA-VEGFR2 signaling pathway; Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2",1272.4,1249.2,1227.4,1690.6,1498.7,1803.2,0.7509263895843766,-0.41325660204324444,0.009925308730715265,2.0032559754504184,0.10892504731651333,0.9628722427367467,666]
["Q15393-1","Splicing factor 3B subunit 3 [OS=Homo sapiens]",41,40,162,40,1217,135.5,5.26,514.36,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","Sf3b3; SF3B3","ENSANAG00000028001; ENSBIXG00000000514; ENSBTAG00000010627; ENSCATG00000036562; ENSCCAG00000017736; ENSCJAG00000014773; ENSG00000189091; ENSGGOG00000003246; ENSHGLG00000010135; ENSMFAG00000045487; ENSMMUG00000017812; ENSMNEG00000033385; ENSPANG00000024075; ENSPPAG00000026807; ENSPTRG00000008308; ENSRBIG00000021904; ENSRROG00000045703; ENSSBOG00000029156; ENSSTOG00000007065; ENSTSYG00000007910","Spliceosome","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","mRNA Processing; mRNA processing; mRNA Processing",16833.1,16819.4,17500.1,17615.3,17328.4,16420.1,0.9958881546926044,-0.005944368388031281,0.8763381793599583,0.05732826701938193,0.9152837600660096,0.03844424328229658,6998]
["Q15435","Protein phosphatase 1 regulatory subunit 7 [OS=Homo sapiens]",44,13,38,13,360,41.5,4.91,122.15,"other biological processes","other cell component","enzyme regulator activity","PPP1R7","ENSG00000115685","","","",3798.7,3775.8,3828.5,3770.2,3464.7,2813.1,1.1348527070063694,0.18250506169149483,0.18530405444217568,0.7321150782385735,0.42887502657310383,0.367669242026876,3158]
["Q15438-1","Cytohesin-1 [OS=Homo sapiens]",32,13,35,9,398,46.4,5.54,109.11,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","CYTH1","ENSCATG00000038229; ENSG00000108669; ENSMFAG00000037544; ENSMMUG00000013313; ENSPANG00000019854; ENSPTRG00000009717","Phospholipase D signaling pathway; Endocytosis; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection","Intra-Golgi traffic","",2300.5,2397.9,2304.8,2761.8,2910.7,4420.9,0.6938395387084629,-0.5273260393981157,0.12435237919163875,0.9053459011064261,0.35684787574074894,0.4475168841860683,2547]
["Q15542","Transcription initiation factor TFIID subunit 5 [OS=Homo sapiens]",16,8,24,8,800,86.8,5.64,63.3,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","TAF5","ENSG00000148835","Basal transcription factors","RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Regulation of TP53 Activity through Phosphorylation","Eukaryotic transcription initiation",1048.7,1172.3,1171.2,1224.8,1114.7,790.2,1.0838738537239991,0.11619685890870472,0.5570627324943995,0.25409589487643097,0.6929155057524788,0.15931972011067694,5876]
["Q15633","RISC-loading complex subunit TARBP2 [OS=Homo sapiens]",2,1,1,1,366,39,6.54,2.9,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TARBP2","ENSG00000139546","","MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis","Fragile X syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies",88.3,64.3,76.1,105.2,99.5,154.4,0.6368699526594264,-0.6509292872529856,0.08134566563451791,1.089665582753681,0.293028817211775,0.5330896679030539,2029]
["Q15637-5","Isoform 5 of Splicing factor 1 [OS=Homo sapiens]",24,12,53,12,673,71.7,9.58,169.22,"","","","SF1","","","","",5778.2,5397.8,5694.1,6633.8,7174.9,6158.3,0.8448990834877547,-0.2431490617130203,0.030738272410609772,1.512320544891671,0.18460643635920035,0.7337531612377631,1217]
["Q15654-1","thyroid receptor-interacting protein 6 [OS=Homo sapiens]",3,1,1,1,476,50.3,7.37,2.8,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","TRIP6","ENSG00000087077","NOD-like receptor signaling pathway","","",20.5,20.2,24.1,20,19.7,23.4,1.0269413629160065,0.0383538079020759,0.7590930870449448,0.11970496361561829,0.8369605329931366,0.07729502074917555,6629]
["Q15696","U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 [OS=Homo sapiens]",10,4,6,4,482,58,9.72,17.05,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","ZRSR2","ENSG00000169249","","mRNA Splicing - Minor Pathway","",308.5,283.2,310.2,292.7,330.3,269.7,1.010305813823233,0.014792054665884237,0.8838466010978743,0.05362310385303673,0.9199707786135521,0.03622596709839617,7022]
["Q15771","Ras-related protein Rab-30 [OS=Homo sapiens]",55,11,24,9,203,23,4.97,71.5,"cell organization and biogenesis;signal transduction","other membranes;ER/Golgi;other cell component","other molecular function","RAB30","ENSG00000137502","","Intra-Golgi traffic; RAB geranylgeranylation","",2236.9,2350.1,2453.2,2138.6,2119.3,2121,1.1036699117402688,0.14230875191473213,0.024628976785490777,1.6085536306150532,0.16560551179866798,0.7809252128173748,1087]
["Q15811-8","Isoform 8 of Intersectin-1 [OS=Homo sapiens]",7,11,19,1,1716,194.7,7.77,55.22,"","","","ITSN1","","","","",1716.5,1524.8,1601.9,1830.6,1785,1324.4,0.9804048582995953,-0.028550461531888637,0.8595141413956436,0.0657469735673051,0.9048233990293474,0.04343617693988548,6943]
["Q15843","NEDD8 [OS=Homo sapiens]",36,4,24,4,81,9.1,8.43,57.78,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","NEDD8","ENSG00000129559; ENSG00000285246","","Cargo recognition for clathrin-mediated endocytosis; UCH proteinases; Neddylation; Iron uptake and transport; TGF-beta receptor signaling activates SMADs","EGF/EGFR signaling pathway",2866.7,2760.5,2600.5,3109.4,3023.6,4198.4,0.796378032018894,-0.32847466982909856,0.14338921167055815,0.8434835229234354,0.37917212304634934,0.4211635997416232,2764]
["Q15904","V-type proton ATPase subunit S1 [OS=Homo sapiens]",9,3,5,3,470,52,6.14,14.3,"transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","ATP6AP1","ENSG00000071553","Oxidative phosphorylation; Metabolic pathways; Lysosome; Phagosome; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Tuberculosis; Hepatitis B; Human papillomavirus infection; Rheumatoid arthritis","Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport; RHOA GTPase cycle","Hepatitis B infection; Oxidative phosphorylation",643,639.1,709.5,529.8,496.7,329.2,1.4690565759386294,0.5548899576738895,0.03277857625359919,1.4844099140551437,0.1893902085672383,0.7226424776830074,1265]
["Q16254","Transcription factor E2F4 [OS=Homo sapiens]",11,4,4,4,413,43.9,4.75,14.49,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","E2F4","ENSG00000205250","Cell cycle; Cellular senescence; TGF-beta signaling pathway","Cyclin D associated events in G1; G1/S-Specific Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest","Cell cycle; Adipogenesis; TGF-beta signaling pathway",414.1,376.7,356.7,512.9,538.4,462.5,0.7580261593341261,-0.39968045850892386,0.01195737972226834,1.9223639789458893,0.11890678692525074,0.9247933561461112,735]
["Q16401","26S proteasome non-ATPase regulatory subunit 5 [OS=Homo sapiens]",46,16,61,16,504,56.2,5.48,181.89,"cell organization and biogenesis","cytosol;nucleus;other cell component","","PSMD5","ENSG00000095261","","Degradation of DVL; Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Parkin-ubiquitin proteasomal system pathway",6945.1,7105.7,7184.1,6357.4,6393.7,5341.4,1.1736852286859196,0.23104554311268913,0.04090210772137873,1.388254311841587,0.20964481440081142,0.6785158754734608,1426]
["Q16540","39S ribosomal protein L23, mitochondrial [OS=Homo sapiens]",13,1,1,1,153,17.8,9.69,2.29,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus","nucleic acid binding activity;other molecular function","MRPL23","ENSG00000214026; ENSG00000288141","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",22.3,25.4,29.2,21.5,27,58.3,0.7200374531835206,-0.4738561437257274,0.4398696129620989,0.35667603888402755,0.6102898635421377,0.21446384328980073,5268]
["Q16563","Synaptophysin-like protein 1 [OS=Homo sapiens]",10,2,2,2,259,28.5,8.43,6.69,"cell-cell signaling","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","SYPL1","ENSG00000008282","","","",330.1,337.9,326.8,307,370.5,360.5,0.9583815028901733,-0.06132803102833672,0.5110593281616326,0.29152868030051743,0.6626454904263567,0.1787187532367325,5637]
["Q16629","serine/arginine-rich splicing factor 7 [OS=Homo sapiens]",37,11,91,10,238,27.4,11.82,225.6,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","nucleus;other cell component","other molecular function","SRSF7","ENSG00000115875","Spliceosome; Amyotrophic lateral sclerosis; Herpes simplex virus 1 infection","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Minor Pathway","mRNA processing",12401.4,13074.8,12734.5,11498.8,12349.7,12064.5,1.0639796174087377,0.08947051348478308,0.07290322647781362,1.1372532506874764,0.27723708757874077,0.5571486721360301,1922]
["Q16690","Dual specificity protein phosphatase 5 [OS=Homo sapiens]",6,1,1,1,384,42,8.35,3.41,"protein metabolism;other metabolic processes;developmental processes;signal transduction","nucleus;other cell component","other molecular function","DUSP5","ENSG00000138166","MAPK signaling pathway","Negative regulation of MAPK pathway; RAF-independent MAPK1/3 activation","Endoderm differentiation; VEGFA-VEGFR2 signaling pathway",15.9,22.2,15.1,34.1,31.9,62.5,0.4140077821011673,-1.272270208580051,0.06794994558477996,1.1678108867201442,0.268893422999002,0.5704198202764126,1847]
["Q16763","ubiquitin-conjugating enzyme E2 S [OS=Homo sapiens]",18,4,6,4,222,23.8,8.38,19.55,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","UBE2S","ENSG00000108106","Ubiquitin mediated proteolysis","APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; APC-Cdc20 mediated degradation of Nek2A; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; APC/C:Cdc20 mediated degradation of Securin; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","",617.2,491.3,539.1,533.5,584,2408.6,0.4672584441734494,-1.097707358670635,0.3681812664224848,0.43393831278018546,0.5673702037280078,0.24613347554808399,4743]
["Q16774-1","guanylate kinase [OS=Homo sapiens]",47,8,28,8,197,21.7,6.55,84.33,"other metabolic processes;transport","cytosol;other cell component","kinase activity;other molecular function","GUK1","ENSG00000143774","Purine metabolism; Metabolic pathways","Interconversion of nucleotide di- and triphosphates; Abacavir metabolism","",3627.3,3517.8,3438.7,3237.1,3625.1,1651.9,1.2430908727874936,0.3139317645543836,0.31850573960712036,0.4968827370892557,0.5407568991378496,0.2669979309949563,4305]
["Q16854","Deoxyguanosine kinase, mitochondrial [OS=Homo sapiens]",3,1,3,1,277,32,8.66,8.22,"protein metabolism;other metabolic processes;other biological processes","cytosol;mitochondrion;other cell component","kinase activity;other molecular function","DGUOK","ENSG00000114956","Purine metabolism; Metabolic pathways","Purine salvage","",163.8,154.3,188.1,151.5,140.2,163.8,1.1113062568605927,0.15225645342127098,0.2367597480354685,0.6256921308849445,0.47423321413845965,0.3240080323656198,3649]
["Q16864-1","V-type proton ATPase subunit F [OS=Homo sapiens]",33,3,7,3,119,13.4,5.52,19.7,"transport","other membranes;cytosol;other cytoplasmic organelle","transporter activity;other molecular function","ATP6V1F","ENSCATG00000033101; ENSG00000128524; ENSGGOG00000023527; ENSMLEG00000037581; ENSPPAG00000012238; ENSPPAG00000027671; ENSPTRG00000019672; ENSPTRG00000040903","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis","ROS and RNS production in phagocytes; Amino acids regulate mTORC1; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Proximal tubule transport",857.9,748.9,789.7,995.1,1154.3,1079.6,0.7421802415608548,-0.43015850099501796,0.007686677376147189,2.114261346678798,0.09770769555175618,1.0100712294844556,575]
["Q17RN3-1","Protein Fam98c [OS=Homo sapiens]",5,2,3,2,349,37.3,7.18,6.77,"","other cell component","","FAM98C","ENSG00000130244","","","",174.9,161.7,172.2,173.7,190.4,409.7,0.6575342465753424,-0.6048620581588612,0.31053288826495234,0.5078923973051102,0.5364417112570401,0.2704774607524318,4231]
["Q29963","HLA class I histocompatibility antigen, Cw-6 alpha chain [OS=Homo sapiens]",46,14,120,3,366,40.9,6,477.31,"other biological processes","plasma membrane;other membranes","","HLA-C","ENSG00000228299","","","",12732.4,13363.1,12886.5,10055.8,10727.7,17440.5,1.0198304730012557,0.028329352111238895,0.9200700491263075,0.03617910657737159,0.9464872609520312,0.02388522695688719,7105]
["Q2KHR3-1","Glutamine and serine-rich protein 1 [OS=Homo sapiens]",0,1,1,1,1735,189.9,7.08,0,"","","","QSER1","ENSG00000060749","","","",14,12.7,16.9,15.7,15.6,13.1,0.9819819819819819,-0.02623154157317966,0.8679550207417882,0.0615027802956113,0.9106923983063063,0.04062828853385581,6966]
["Q2NKX8","Dna excision repair protein ercc-6-like [OS=Homo sapiens]",23,21,34,21,1250,141,5.31,102.91,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","ERCC6L","ENSG00000186871","","RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",2544.6,2508,2623,2524.6,2567.5,5268.8,0.7408236736190871,-0.4327978930668255,0.3801862938766882,0.4200035439698345,0.5747221555211405,0.24054206050488197,4835]
["Q2TAL8","Glutamine-rich protein 1 [OS=Homo sapiens]",6,4,7,4,776,86.4,5.87,22.38,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cell component","nucleic acid binding activity","QRICH1","ENSG00000198218","","","",631.1,703.9,663.1,759.8,692.5,536.7,1.0045751633986928,0.006585512110757159,0.967207586427357,0.014480305684694472,0.9772353123026752,0.010000848226322433,7234]
["Q2TB10","zinc finger protein 800 [OS=Homo sapiens]",21,12,19,12,664,75.2,9.47,45.09,"","nucleus","nucleic acid binding activity;other molecular function","ZNF800","ENSG00000048405","","","",1309.7,1276.6,1366.3,1635.6,1579.6,1762.9,0.7939977099696672,-0.3327932485017098,0.004754024048633306,2.322938625686861,0.0765355986155525,1.1161365166599924,454]
["Q32MZ4-3","Isoform 3 of Leucine-rich repeat flightless-interacting protein 1 [OS=Homo sapiens]",52,30,133,27,752,82.6,4.61,441.23,"","","","LRRFIP1","","","","",11672.5,11491.7,11794.3,14100.8,14601.2,13843.5,0.8216732674430903,-0.28336326441919213,4.5274618134066245E-4,3.3441452040280897,0.028774972516686103,1.5409850824977283,115]
["Q32P28-1","Prolyl 3-hydroxylase 1 [OS=Homo sapiens]",4,3,6,3,736,83.3,5.14,16.19,"protein metabolism;other metabolic processes;developmental processes;other biological processes","ER/Golgi;nucleus;other cell component","other molecular function","P3H1","ENSG00000117385","","Collagen biosynthesis and modifying enzymes","Type I collagen synthesis in the context of osteogenesis imperfecta",729,689.9,663.4,687.9,732.5,557.1,1.0529962073324906,0.07450024009348598,0.5663971698553832,0.24687892537347955,0.6991719159724702,0.1554160245715068,5921]
["Q3B820-3","Isoform 3 of Protein FAM161A [OS=Homo sapiens]",5,3,4,2,716,83.4,8.66,10.04,"","","","FAM161A","","","","",62.7,57.2,65.9,86,83.5,90.5,0.7146153846153847,-0.48476112153316386,1.6249417820798499E-3,{"$f":"-LOG10(AA3331)","v":2.789162194177041},0.04808380358389321,{"$f":"-LOG10(AC3331)","v":1.3180011855527334},247]
["Q3MHD2","Protein LSM12 homolog [OS=Homo sapiens]",18,4,11,4,195,21.7,7.74,27.54,"","","","LSM12","ENSG00000161654","","","",840.9,744.4,719.7,1263.9,1260.4,1284.1,0.6052410461086021,-0.7244182636293099,0.0001852865739489,3.732156048955017,0.022200976540860822,1.653627922081811,61]
["Q3SXM5","Inactive hydroxysteroid dehydrogenase-like protein 1 [OS=Homo sapiens]",9,3,13,3,330,37,8.72,40.46,"","cytoskeleton;mitochondrion;other cell component","other molecular function","HSDL1","ENSG00000103160","","","",1103.3,1132.6,1225.3,1079.3,900.2,901.6,1.201346707854639,0.26465257195761593,0.05055602927494355,1.2962270433431562,0.23611119359141367,0.6268834233416505,1565]
["Q460N5-1","Isoform 1 of Poly [ADP-ribose] polymerase 14 [OS=Homo sapiens]",3,3,3,3,1720,193.6,7.97,6.48,"","","","PARP14","","","","",49,44.2,51.1,46.5,52.5,57.8,0.9202806122448979,-0.11985425962401022,0.34005154286180356,0.46845525035802327,0.5528106598703119,0.25742359103505497,4496]
["Q49MG5","Microtubule-associated protein 9 [OS=Homo sapiens]",2,2,3,2,647,74.2,7.8,3.64,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;other cell component","cytoskeletal activity","MAP9","ENSG00000164114","","","",468.4,473.2,455.4,672.8,630.8,260.3,0.8932796214591727,-0.16281624502034295,0.6932851535697105,0.1590880999480448,0.7917533105376584,0.10141011204795905,6400]
["Q4G0F5","Vacuolar protein sorting-associated protein 26B [OS=Homo sapiens]",25,9,32,7,336,39.1,7.36,93.1,"stress response;transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","VPS26B","ENSG00000151502","Endocytosis","","",2625.3,2655.9,2871.5,2717.9,2493.8,1622.7,1.1928918412735574,0.2544632407430496,0.2692635731899537,0.5698223953171749,0.5047569778008134,0.2969176686211877,3899]
["Q4KMP7","TBC1 domain family member 10B [OS=Homo sapiens]",21,13,41,13,808,87.1,9.19,100.53,"transport;other biological processes","plasma membrane;other membranes;cytosol","enzyme regulator activity","TBC1D10B","ENSG00000169221","","TBC/RABGAPs","",2616.8,2617.2,2760.3,2559.6,2741.8,4049.2,0.8549504844608904,-0.2260872279780999,0.39197647147765763,0.4067400008726377,0.5824265155580808,0.23475886154799605,4919]
["Q4KMQ1","Taperin [OS=Homo sapiens]",12,4,4,4,711,75.5,7.25,13.69,"cell organization and biogenesis;developmental processes;other biological processes","other cell component","other molecular function","TPRN","ENSG00000176058","","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea","",327.7,266.4,303.5,283.9,319.4,286.7,1.0085393258426965,0.012267339867670146,0.9104623618676516,0.040738003049788765,0.9403093687848899,0.026729236771073684,7077]
["Q504Q3","PAN2-PAN3 deadenylation complex catalytic subunit PAN2 [OS=Homo sapiens]",7,6,10,6,1202,135.3,5.99,31.96,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PAN2","ENSG00000135473","RNA degradation","Deadenylation of mRNA","Ectoderm differentiation; Ectoderm differentiation",446,471.5,516.8,459.6,526,485.4,0.9750509857239973,-0.03645043507334169,0.6880461943482625,0.1623824029315433,0.788233485030008,0.10334511976873265,6380]
["Q53EZ4-1","Centrosomal protein of 55 kDa [OS=Homo sapiens]",21,9,13,9,464,54.1,7.01,32.64,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cell component","other molecular function","CEP55","ENSG00000138180","","","",910.1,761.9,722.3,978.3,1000.4,1511.2,0.6860655033095505,-0.5435817680689133,0.11700339301627535,0.9318015438360694,0.3462258297797395,0.46064053521176224,2470]
["Q53FT3","Protein Hikeshi [OS=Homo sapiens]",15,3,8,3,197,21.6,5.45,23.91,"cell organization and biogenesis;stress response;transport;developmental processes","cytosol;nucleus","other molecular function","HIKESHI","ENSG00000149196","","Regulation of HSF1-mediated heat shock response","",789,874.1,872.1,712.9,786.5,662.9,1.1724552559774313,0.22953286669699166,0.052502349648775676,1.2798212600861694,0.23998728804434108,0.6198117619484311,1599]
["Q53H47","Histone-lysine N-methyltransferase SETMAR [OS=Homo sapiens]",6,4,5,4,684,78,7.14,13.3,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SETMAR","ENSG00000170364","Lysine degradation; Metabolic pathways","","Histone modifications",310.6,372.9,356.4,350.6,392.1,510.5,0.82979572294925,-0.26917187380193625,0.2387962670798189,0.6219724664844917,0.4762242608694124,0.3221884835776654,3665]
["Q53QZ3","Rho GTPase-activating protein 15 [OS=Homo sapiens]",23,10,14,10,475,54.5,9.39,36.96,"signal transduction;other biological processes","other membranes;cytosol;other cell component","enzyme regulator activity","ARHGAP15","ENSG00000075884","","RAC1 GTPase cycle; RAC3 GTPase cycle","Ectoderm differentiation; Ectoderm differentiation",983.3,1008.1,1006.7,1023.6,968.2,1111.1,0.9662251442199234,-0.04956869816230534,0.45596810629132695,0.3410655339717527,0.6219990460775119,0.20621028135996977,5358]
["Q53S33","BolA-like protein 3 [OS=Homo sapiens]",7,1,1,1,107,12.1,9.64,2.1,"","cytosol;mitochondrion;nucleus","","BOLA3","ENSG00000163170","","","",81.3,72.1,75.9,69.6,75.2,54.8,1.1487975951903804,0.20012463424353247,0.21050973075176488,0.6767278242267848,0.45120692729168604,0.34562424133530956,3410]
["Q567V2-1","Mpv17-like protein 2 [OS=Homo sapiens]",5,1,1,1,206,23.2,9.25,0,"cell organization and biogenesis;other biological processes","other membranes;mitochondrion;translational apparatus;other cell component","","FKSG24; MPV17L2","ENSG00000254858; ENSGGOG00000008883; ENSPPAG00000039781; ENSPTRG00000010696","Peroxisome","","",113.5,124.3,130.9,160,183.3,496.3,0.4391376846117199,-1.1872547501983364,0.22167993573332784,0.6542736131310265,0.46359331910583496,0.3338628313287537,3495]
["Q56VL3","OCIA domain-containing protein 2 [OS=Homo sapiens]",55,9,40,9,154,16.9,9.03,115.42,"transport;other biological processes","ER/Golgi;other cytoplasmic organelle","","OCIAD2","ENSG00000145247","","","",3926.2,4063.3,4058.5,4296.2,4016.7,3990,0.9792813076591699,-0.030204747960902296,0.4744139882739579,0.32384251411970416,0.6370552710443429,0.19582288655280497,5443]
["Q5BKT4","Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase [OS=Homo sapiens]",1,1,1,1,473,55.6,9.29,1.85,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","ALG10","ENSG00000139133","N-Glycan biosynthesis; Metabolic pathways","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein","",65.9,60.7,63.8,64.5,69.9,65.4,0.9529529529529529,-0.06952310448447489,0.2364900534170726,0.6261871206213934,0.4743429748697541,0.32390752703838105,3644]
["Q5F1R6","DnaJ homolog subfamily C member 21 [OS=Homo sapiens]",23,10,15,10,531,62,5.47,39.69,"other biological processes","cytosol;translational apparatus;nucleus","other molecular function","DNAJC21","ENSG00000168724","","","",1350.8,1335.4,1327.5,1381.4,1536.1,1555.5,0.8973172367538563,-0.15630997041297914,0.050947271153088135,1.2928790727938473,0.23672829298024234,0.6257498335331612,1573]
["Q5GJ75","Tumor necrosis factor alpha-induced protein 8-like protein 3 [OS=Homo sapiens]",10,2,2,2,292,32.6,8.59,4.37,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","transporter activity;other molecular function","TNFAIP8L3","ENSG00000183578","","PI Metabolism","",54.3,49.1,56.1,53.8,50.9,74,0.8925573587017348,-0.16398321038925875,0.44503276756515037,0.3516080109318446,0.6134938698856439,0.21218977244494622,5302]
["Q5HYK3-1","2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial [OS=Homo sapiens]",24,6,13,6,327,37.1,6.95,36.6,"other metabolic processes","other membranes;mitochondrion;other cell component","other molecular function","COQ5","ENSG00000110871","Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways; Biosynthesis of cofactors","Ubiquinol biosynthesis","",792.4,786.3,749.1,724.6,672.4,2468.3,0.6022300985693219,-0.7316132812592284,0.4342556813240657,0.36225449101200613,0.6080411445972407,0.21606703213029535,5220]
["Q5JRA6-1","Transport and Golgi organization protein 1 homolog [OS=Homo sapiens]",40,63,179,63,1907,213.6,4.84,539.69,"cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","MIA3","ENSG00000154305","","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cargo concentration in the ER","Type I collagen synthesis in the context of osteogenesis imperfecta",17089.8,15786.7,16923.6,17858.1,18942.9,17829.9,0.9115738528927768,-0.13356855120003938,0.042789875020101495,1.368658981993738,0.21554183082144854,0.666468432547501,1451]
["Q5JS54-1","Proteasome assembly chaperone 4 [OS=Homo sapiens]",30,3,5,3,123,13.8,6.52,15.87,"cell organization and biogenesis","other cell component","other molecular function","PSMG4","ENSG00000180822; ENSGGOG00000012606; ENSPTRG00000033938","","","",583.4,626.3,560.8,673.8,575.4,556.4,0.9805604785112981,-0.028321479913557598,0.7902324524130063,0.10224513915154482,0.8584733939783982,0.06627316005742764,6728]
["Q5JTJ3-1","Cytochrome c oxidase assembly factor 6 homolog [OS=Homo sapiens]",11,1,1,1,125,14.1,8.25,2.19,"cell organization and biogenesis;other metabolic processes","plasma membrane;other membranes;mitochondrion;nucleus","other molecular function","COA6","ENSG00000168275; ENSPTRG00000002122","Thermogenesis","Mitochondrial protein import","Mitochondrial complex IV assembly",15.1,20.8,23.9,15.8,17.9,30.8,0.9271317829457364,-0.10915367611251149,0.7842424523663832,0.10554965230685688,0.8536155002748913,0.06873770742761807,6715]
["Q5JTW2-1","Centrosomal protein of 78 kDa [OS=Homo sapiens]",9,5,5,5,689,76.3,8.18,17.8,"cell organization and biogenesis","cytosol;cytoskeleton","","CEP78","ENSG00000148019","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","Ciliopathies",380.5,420.5,433.2,551.9,547.2,519.7,0.762416604892513,-0.3913485544233337,2.411885912690218E-3,2.617643239094459,0.05705007810955599,1.2437437566353209,309]
["Q5JWF2-1","Guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas [OS=Homo sapiens]",17,14,58,1,1037,111,5.03,185.46,"cell adhesion;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","GNAS","ENSG00000087460","","G alpha (i) signalling events; G alpha (z) signalling events; G alpha (s) signalling events; ADORA2B mediated anti-inflammatory cytokines production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Prostacyclin signalling through prostacyclin receptor; Glucagon-type ligand receptors; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation in glucagon signalling; Hedgehog 'off' state","Thyroid stimulating hormone (TSH) signaling pathway; Endothelin pathways; Corticotropin-releasing hormone signaling pathway; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; G protein signaling pathways; Thermogenesis; Hippo signaling regulation pathways; Purinergic signaling; Prostaglandin and leukotriene metabolism in senescence ; Calcium regulation in cardiac cells; Estrogen signaling pathway; Serotonin receptor 4/6/7 and NR3C signaling",6024.4,6169.7,6299,5142.9,5283.6,4193.7,1.2649006169546242,0.33902403704668876,0.021308052742740453,1.6714562368988097,0.15389383151846836,0.812778787518617,1012]
["Q5MNZ9","WD repeat domain phosphoinositide-interacting protein 1 [OS=Homo sapiens]",7,1,4,1,446,48.6,6.6,18.58,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport","other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","WIPI1","ENSG00000070540","Autophagy; Autophagy; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis","XBP1(S) activates chaperone genes; Macroautophagy","Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Alzheimer's disease",50.2,42.8,51.5,41,42.5,145.1,0.632108486439195,-0.6617559108264373,0.4627739495851899,0.33463109628430676,0.6273024476109335,0.20252301792759722,5392]
["Q5PSV4","Breast cancer metastasis-suppressor 1-like protein [OS=Homo sapiens]",5,2,4,2,323,37.6,5.15,9.87,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","BRMS1L","ENSG00000100916","","","Genotoxicity pathway",431.1,422.5,431.2,420.3,470.5,1098.3,0.6459202654466845,-0.6305720100678068,0.342400074599217,0.46546614937448494,0.554163451117289,0.25636212074344217,4516]
["Q5RKV6","Exosome complex component MTR3 [OS=Homo sapiens]",42,12,34,12,272,28.2,6.28,112.9,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cytoplasmic organelle;other cell component","","EXOSC6","ENSG00000223496","RNA degradation","Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease","",3277.9,3368.5,3288.6,3278.4,3511.4,4961.6,0.845431182667597,-0.2422407695422577,0.3148866997273267,0.5018456828281027,0.5386161685717367,0.2687206137613263,4273]
["Q5SRD1","Putative mitochondrial import inner membrane translocase subunit Tim23B [OS=Homo sapiens]",14,2,6,2,257,28,9.39,26.68,"","","","","","","","",555.1,574.5,634.5,782.6,655.4,874.7,0.7627880831928049,-0.39064578984830584,0.05452234957355765,1.2634254370478555,0.2440317532352314,0.6125536599005507,1633]
["Q5SSJ5-1","Heterochromatin protein 1-binding protein 3 [OS=Homo sapiens]",48,24,119,24,553,61.2,9.67,300.56,"cell organization and biogenesis;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HP1BP3","ENSG00000127483; ENSPPAG00000040189; ENSPTRG00000000296","","","",22169.6,22095.8,22150.7,18053.8,18472,15989.1,1.2647096347893643,0.3388061939832744,3.8005451549432906E-3,2.4201541031720253,0.07086271565683805,1.1495822083085094,392]
["Q5SZL2","Centrosomal protein of 85 kDa-like [OS=Homo sapiens]",1,1,3,1,805,91.8,6.33,5.03,"developmental processes","cytoskeleton;other cell component","","CEP85L","ENSG00000111860","","","",705.1,519.3,547.5,550.5,695.9,240.7,1.1915136843520946,0.2527955207548187,0.5513922854363926,0.2585393144287265,0.6887927216295665,0.16191145065547183,5851]
["Q5T0D9","Tumor protein p63-regulated gene 1-like protein [OS=Homo sapiens]",31,3,10,3,272,30.2,7.34,53.52,"other biological processes","other membranes;ER/Golgi;other cell component","","TPRG1L","ENSG00000158109","","","",365.1,407.3,415,391.5,387.6,441.3,0.9729596853490659,-0.03954806680998805,0.660455983700255,0.1801561207793193,0.7676960535727042,0.11481069192669784,6288]
["Q5T3I0","G patch domain-containing protein 4 [OS=Homo sapiens]",36,16,26,16,446,50.4,9.63,81.55,"","","","GPATCH4","","","","",2425.8,2204,2416,2980.1,3238.9,3530.2,0.7227054527550978,-0.46852031552954576,6.6916161667031045E-3,2.1744689782690587,0.09280649442586905,1.0324216315976324,527]
["Q5T4S7-1","e3 ubiquitin-protein ligase UBR4 [OS=Homo sapiens]",24,98,284,98,5183,573.5,6.04,848.76,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus","other molecular function","UBR4","ENSG00000127481","Human papillomavirus infection; Viral carcinogenesis","Neutrophil degranulation; Antigen processing: Ubiquitination & Proteasome degradation","",25339.1,25516.6,25683.7,24102.5,23574.9,25234.9,1.0497460647929087,0.07004037991915832,0.07279815882908638,1.1378796044847594,0.2772703193756083,0.557096617336258,1919]
["Q5T5U3","rho GTPase-activating protein 21 [OS=Homo sapiens]",2,2,2,2,1957,217.2,7.8,7.72,"","","","","","","","",81.6,76.8,90.6,79.3,75,456.2,0.4078624078624078,-1.2938455529193225,0.3944817047212731,0.40397313370384424,0.5836572428760698,0.23384212074351826,4940]
["Q5T6V5","queuosine salvage protein [OS=Homo sapiens]",11,4,6,4,341,39,5.88,14.13,"RNA metabolism OR transcription;other metabolic processes","","","C9orf64","ENSG00000165118","","","",579,540.7,581.4,563.6,486.9,358.5,1.2073101490418736,0.2717963413840417,0.1872095805765886,0.7276719297160845,0.4305584721316193,0.36596786070347226,3178]
["Q5TAQ9-1","DDB1- and CUL4-associated factor 8 [OS=Homo sapiens]",20,12,20,12,597,66.8,5.39,49.73,"protein metabolism;other metabolic processes","cytosol;mitochondrion;nucleus;other cell component","","DCAF8","ENSG00000132716; ENSPPAG00000008803; ENSPTRG00000001546","","Neddylation","",2669.9,2679,2867.4,2433.9,2456.1,2119,1.1722499643315736,0.22928023516138854,0.03346452342344627,1.4754153555115574,0.19108765757966312,0.7187673632754528,1280]
["Q5TC12-1","ATP synthase mitochondrial F1 complex assembly factor 1 [OS=Homo sapiens]",14,4,11,4,328,36.4,7.96,31.61,"cell organization and biogenesis","mitochondrion","","ATPAF1","ENSG00000123472","","","7q11.23 copy number variation syndrome",880.7,849.2,902,792,827.2,515.8,1.2327400468384078,0.30186860454469894,0.17180527345881424,0.7649635098940982,0.4134753848239952,0.3835503399283904,3037]
["Q5TF39","Sodium-dependent glucose transporter 1 [OS=Homo sapiens]",6,2,2,2,518,56.2,5.43,6.55,"transport","plasma membrane;other membranes","transporter activity","MFSD4B","ENSG00000173214","","Cellular hexose transport","",219.7,219.8,216.5,206.2,205.9,270.3,0.9613130128956622,-0.05692183181284443,0.7025661857872638,0.1533127564503337,0.7984848782334181,0.09773330414912854,6431]
["Q5TGZ0","MICOS complex subunit Mic10 [OS=Homo sapiens]",10,1,2,1,78,8.8,8.5,5.26,"cell organization and biogenesis","mitochondrion","","MICOS10","ENSG00000173436","","Cristae formation","",409.3,411.1,408.5,350.9,305.7,184,1.461931953366643,0.5478761616151344,0.06025373760562583,1.2200160081530496,0.2555975439115027,0.5924433237171051,1723]
["Q5VIR6-4","Isoform 4 of Vacuolar protein sorting-associated protein 53 homolog [OS=Homo sapiens]",26,17,47,17,832,94.3,6.7,140.26,"transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","VPS53","ENSG00000141252; ENSG00000283883","","Retrograde transport at the Trans-Golgi-Network","",3870.8,3883.4,3951,3855.7,3837.7,3836.5,1.01520394799608,0.021769584755891094,0.0850727356465074,1.0702096015540945,0.2993724722389613,0.5237881362052206,2077]
["Q5VTE6-1","protein angel homolog 2 [OS=Homo sapiens]",11,5,8,5,544,62.3,7.81,15.84,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ANGEL2","ENSG00000174606; ENSPPAG00000031266; ENSPTRG00000001970","","","",579.6,566.4,580.2,566.8,553.2,427.7,1.1153324287652646,0.15747377458661327,0.25219587818112643,0.5982620156924393,0.48867965896761745,0.3109757378737571,3772]
["Q5VTY9-1","Protein-cysteine N-palmitoyltransferase HHAT [OS=Homo sapiens]",3,1,1,1,493,57.3,7.28,3.27,"protein metabolism;other metabolic processes;signal transduction","other membranes;ER/Golgi","other molecular function","HHAT","ENSG00000054392; ENSG00000280680","Hedgehog signaling pathway","Hedgehog ligand biogenesis; HHAT G278V doesn't palmitoylate Hh-Np","",69.5,71.5,88.3,51.6,65.1,56.5,1.3239030023094691,0.4047974248540689,0.059057995035544424,1.2287213010177367,0.2543635154477279,0.5945451814514395,1697]
["Q5VW32","BRO1 domain-containing protein BROX [OS=Homo sapiens]",27,10,25,10,411,46.4,7.65,66.72,"","other membranes","","BROX","ENSG00000162819","","","",4247.1,4353.9,4577.9,4128.8,3936.4,2853.4,1.2070137197076547,0.27144207480188504,0.13908052100102652,0.8567336911017568,0.3752453038008501,0.425684734250952,2709]
["Q5VYS8-1","terminal uridylyltransferase 7 [OS=Homo sapiens]",20,22,38,21,1495,171.1,6.83,111.51,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TUT7","ENSG00000083223","","Deadenylation of mRNA","",2962.1,3051.1,2999.5,3878.7,3931.4,3905.8,0.7692708199967565,-0.3784365098552241,7.2727331389284764E-6,5.138302347863336,0.01771880217080941,1.7515656406990254,3]
["Q5VZE5","N-alpha-acetyltransferase 35, NatC auxiliary subunit [OS=Homo sapiens]",10,5,5,5,725,83.6,7.05,14.31,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","","NAA35","ENSG00000135040","","Retrograde transport at the Trans-Golgi-Network","",180.1,179.3,185.4,170.3,173.1,273.2,0.8835549789166397,-0.17860818609510393,0.5191040819349447,0.2847455560665332,0.6683339325105709,0.17500648840797306,5677]
["Q5W0Z9-1","Probable palmitoyltransferase ZDHHC20 [OS=Homo sapiens]",5,1,2,1,365,42.3,7.71,5.62,"protein metabolism;other metabolic processes;transport","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","ZDHHC20","ENSG00000180776; ENSPPYG00000005201","","","",61.2,75.1,67.4,64.9,73.8,185.9,0.6275415896487986,-0.6722170195820834,0.36138535036377223,0.44202945660388787,0.564756366433357,0.24813886462841908,4677]
["Q5XKP0","MICOS complex subunit MIC13 [OS=Homo sapiens]",75,5,22,5,118,13.1,9.42,65.16,"cell organization and biogenesis","other membranes;mitochondrion;nucleus","","MICOS13","ENSG00000174917","","Cristae formation","",2737.9,2790.4,2713.7,2745.9,2400.8,4536.8,0.8511385346207466,-0.23253412520385291,0.5083810796151695,0.2938106209261167,0.6606965346563431,0.17999797105391135,5624]
["Q63ZY3-1","KN motif and ankyrin repeat domain-containing protein 2 [OS=Homo sapiens]",3,2,3,2,851,91.1,5.63,9.86,"developmental processes;other biological processes","mitochondrion;other cell component","","KANK2","ENSG00000197256","","","",168.8,177.6,175.3,179.5,205.8,246.4,0.8258667088807978,-0.2760191388526634,0.13525705915319328,0.8688400595206492,0.3706763574618259,0.43100511332655234,2667]
["Q66K14-1","TBC1 domain family member 9B [OS=Homo sapiens]",14,14,25,12,1250,140.4,5.25,84.37,"transport;other biological processes","other membranes","enzyme regulator activity;other molecular function","TBC1D9B","ENSG00000197226; ENSG00000284400","","","",1603.1,1620.9,1666.6,1432.5,1442.3,1248.5,1.1860888123590327,0.2462120405354997,0.017740629544215184,1.7510309728510998,0.14296169938111222,0.844780298027222,907]
["Q676U5","Autophagy-related protein 16-1 [OS=Homo sapiens]",12,6,7,6,607,68.2,6.64,17.74,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","ATG16L1","ENSG00000085978; ENSG00000281089","Autophagy; Autophagy; NOD-like receptor signaling pathway; Shigellosis","Macroautophagy","Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; LDLRAD4 and what we know about it; Autophagy; Senescence and autophagy in cancer",463.7,445.4,449.5,404.9,438.9,602,0.939687370314013,-0.08974723630664085,0.6589988764311773,0.18111532586146165,0.7667339681368155,0.11535529603997463,6282]
["Q68CZ6","HAUS augmin-like complex subunit 3 [OS=Homo sapiens]",4,3,4,3,603,69.6,5.55,2.05,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","non-structural extracellular;cytosol;cytoskeleton;mitochondrion;nucleus","","HAUS3","ENSG00000214367","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",286.3,256.6,274.9,238.9,259.9,73.6,1.4287211740041932,0.5147243907996983,0.24147437280969655,0.617128953268177,0.47895147649011455,0.3197084835792742,3685]
["Q68DQ2","very large A-kinase anchor protein [OS=Homo sapiens]",5,13,14,13,2970,330.4,5.2,33.18,"developmental processes;other biological processes","other cell component","other molecular function","CRYBG3","ENSG00000080200","","","",940.9,983.6,1009.1,1106.4,1246.4,1336.5,0.7951643943295477,-0.3306749371750988,0.022617055976722613,1.6455639270973532,0.1581895331424551,0.8008222556604531,1045]
["Q69YH5-1","cell division cycle-associated protein 2 [OS=Homo sapiens]",23,18,40,17,1023,112.6,8.4,106.03,"cell cycle OR cell proliferation;other biological processes","cytosol;nucleus;other cell component","","CDCA2","ENSG00000184661","","","",3911.3,3981.2,3992,2862.2,2915.8,4265.1,1.1833497625235234,0.24287655387926937,0.25268791507376626,{"$f":"-LOG10(AA3651)","v":0.597415527934773},0.4893736012915097,{"$f":"-LOG10(AC3651)","v":0.31035946187971264},3774]
["Q6BCY4","NADH-cytochrome b5 reductase 2 [OS=Homo sapiens]",4,1,1,1,276,31.4,8.5,2.31,"other metabolic processes;transport","other membranes;ER/Golgi","other molecular function","CYB5R2","ENSG00000166394","Amino sugar and nucleotide sugar metabolism","Erythrocytes take up carbon dioxide and release oxygen","Oxidation by cytochrome P450",73.6,57.7,65.4,74,60.3,48.6,1.0754510661563697,0.10494188252981382,0.6233169009785557,0.20529109723408182,0.7418699282286703,0.12967223273227693,6141]
["Q6DD87","Zinc finger protein 787 [OS=Homo sapiens]",14,3,5,3,383,40.5,7.84,20.81,"","","","","","","","",627.4,565.4,554.7,617.3,722.8,619.7,0.8916726196550668,-0.16541397744867115,0.16339945421540816,0.7867493984255887,0.4032027720663127,0.39447649072680535,2962]
["Q6DT37","Serine/threonine-protein kinase MRCK gamma [OS=Homo sapiens]",4,5,5,5,1551,172.4,6.28,16.18,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction","cytosol;cytoskeleton;other cell component","kinase activity;other molecular function","CDC42BPG","ENSG00000171219","","","",386.6,393.4,395.5,499.8,468.7,724.4,0.6943706066513083,-0.5262222164251239,0.0991018143643456,1.0039183943420675,0.32264372436035726,0.49127677779743656,2245]
["Q6IA69","glutamine-dependent NAD(+) synthetase [OS=Homo sapiens]",14,8,12,8,706,79.2,6.44,32.21,"other metabolic processes","cytosol;other cell component","other molecular function","NADSYN1","ENSG00000172890","Nicotinate and nicotinamide metabolism; Metabolic pathways; Biosynthesis of cofactors","Nicotinate metabolism","NAD biosynthesis II (from tryptophan); NAD+ biosynthetic pathways",773.9,817.5,847.9,792.5,839.6,724.2,1.0352247167168867,0.049943968211207265,0.525157826979286,0.2797101573837368,0.6713973338099706,0.17302038771403638,5717]
["Q6IAN0","Dehydrogenase/reductase SDR family member 7B [OS=Homo sapiens]",23,6,11,6,325,35.1,9.55,27.45,"other metabolic processes","other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","DHRS7B","ENSG00000109016","","Plasmalogen biosynthesis","",1112,1119.9,1139.6,1030.5,1020,1536.2,0.9400005576156355,-0.08926648227892407,0.6956458670747148,0.1576117907280752,0.7940770954941575,0.10013733066826981,6403]
["Q6IEG0-1","U11/U12 small nuclear ribonucleoprotein 48 kDa protein [OS=Homo sapiens]",2,1,1,1,339,39.9,6.95,1.64,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","other molecular function","SNRNP48","ENSG00000168566","","mRNA Splicing - Minor Pathway","",109.2,110.2,120.9,111.7,109.8,159.8,0.8924731182795699,-0.16411937976110666,0.4611459811808002,0.3361615718220587,0.6257920490996043,0.20356995901357733,5386]
["Q6JQN1","Acyl-CoA dehydrogenase family member 10 [OS=Homo sapiens]",2,2,2,2,1059,118.8,8.06,3.95,"other metabolic processes","mitochondrion","other molecular function","ACAD10","ENSG00000111271","","Mitochondrial Fatty Acid Beta-Oxidation","",115.3,123,143.1,123.2,133.3,186.3,0.8613369467028004,-0.215350378468796,0.3900368908275068,0.4088943141911524,0.5811987023564215,0.2356753640231468,4905]
["Q6KCM7-3","Isoform 3 of Calcium-binding mitochondrial carrier protein SCaMC-2 [OS=Homo sapiens]",14,6,14,6,515,56.8,8.46,36.72,"","","","SLC25A25","","","","",1099.9,1081.3,1128.4,1120.5,1208.3,2127.7,0.7426455738808482,-0.4292542432087964,0.3013165270789614,0.5209770468120505,0.5295317375379007,0.27610800529301105,4159]
["Q6NT16","MFS-type transporter SLC18B1 [OS=Homo sapiens]",2,1,1,1,456,48.8,5.22,2.8,"transport","other membranes","transporter activity","SLC18B1","ENSG00000146409","","","",83.7,76.2,83.2,71,63,59.7,1.2550335570469802,0.32772593942547545,0.016397720209343453,1.785216528130726,0.13791822440746984,0.8603783426954195,869]
["Q6NUK1","Calcium-binding mitochondrial carrier protein SCaMC-1 [OS=Homo sapiens]",32,14,38,14,477,53.3,6.33,111,"stress response;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","SLC25A24","ENSG00000085491; ENSG00000284468","","","",4709.6,4611.3,4721.2,3989.5,4226,3767.7,1.171815541758462,0.22874548961146635,0.00740919689097932,2.130228864182403,0.09704985676732589,1.0130051012360088,558]
["Q6NW29","RWD domain-containing protein 4 [OS=Homo sapiens]",11,2,3,2,188,21.2,5.31,8.35,"","","","RWDD4","ENSG00000182552","","","",289.3,274.3,287.7,378.6,393.2,504.5,0.6670061897672961,-0.5842279453138625,0.024055407140417078,1.6187872882172412,0.1644723767907469,0.7839070315420462,1069]
["Q6NXR4","TELO2-interacting protein 2 [OS=Homo sapiens]",24,10,19,10,508,56.9,7.09,61.94,"","cytosol;cytoskeleton;nucleus","","TTI2","ENSG00000129696","","","",1539.8,1480.9,1493.4,1596.3,1613.9,1698.2,0.919668323690001,-0.12081444463468931,0.02213052771546574,1.6550082299415965,0.15719341795173866,0.8035656428200565,1029]
["Q6P0N0","Mis18-binding protein 1 [OS=Homo sapiens]",3,3,3,3,1132,129,9.25,5.18,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","nucleic acid binding activity","MIS18BP1","ENSG00000129534","","Deposition of new CENPA-containing nucleosomes at the centromere","",158.5,163.9,160.8,202.9,206.1,571.1,0.4930109172533415,-1.0203085008341404,0.24680709130322,0.6076423662367939,0.4833636201326997,0.3157260394272832,3732]
["Q6P1L8","39S ribosomal protein L14, mitochondrial [OS=Homo sapiens]",13,1,1,1,145,15.9,10.24,5.95,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL14","ENSG00000180992","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",36.6,41.9,49.1,34.3,45.7,52.2,0.9652042360060514,-0.051093847742822315,0.8214237058612517,0.08543276778846562,0.87877427783078,0.056122663585441275,6832]
["Q6P1X5","Transcription initiation factor TFIID subunit 2 [OS=Homo sapiens]",6,6,9,6,1199,136.9,8.19,23.55,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","TAF2","ENSG00000064313","Basal transcription factors","Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation","",546.9,547.5,519.8,547,540.5,737.8,0.8843477784473787,-0.17731425969183068,0.3422084134149343,0.4657093172532388,0.5547130835328797,0.2559315906758364,4509]
["Q6P1X6","UPF0598 protein C8orf82 [OS=Homo sapiens]",24,4,5,4,216,23.9,9.14,16.32,"","","","C8orf82","ENSG00000213563","","","",257.2,248.8,266.8,283.5,230.3,341.8,0.9032258064516128,-0.14684138832927132,0.44508535059325843,0.3515566997215461,0.6134506557582737,0.21222036495613583,5303]
["Q6P3X3","tetratricopeptide repeat protein 27 [OS=Homo sapiens]",25,16,26,16,843,96.6,5.59,62.23,"","","","TTC27","ENSG00000018699","","","",2168.1,2233.2,2157.6,2135.3,2182.2,1707.7,1.0885779725154352,0.12244474839200703,0.3090199600562788,0.5100134679462419,0.5353465010787726,0.27136503144415,4219]
["Q6P4E1","Protein CASC4 [OS=Homo sapiens]",32,16,37,16,433,48.8,5.82,88.85,"","","","","","","","",3790.5,3703.3,3750.5,4092.6,4348.4,5297.2,0.8184696685155259,-0.28899914171029467,0.08635758892898812,1.063699491505168,0.30157076802769905,0.5206107579598817,2093]
["Q6P6C2-2","RNA demethylase ALKBH5 [OS=Homo sapiens]",24,6,10,6,394,44.2,9.09,30.01,"RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes","cytosol;ER/Golgi;nucleus","other molecular function","ALKBH5","ENSCSAG00000008183; ENSG00000091542; ENSMFAG00000001517; ENSMMUG00000018352; ENSMNEG00000037007; ENSPANG00000023682; ENSPPAG00000030479; ENSPTRG00000024216; ENSRBIG00000029698; ENSRROG00000033654","","Reversal of alkylation damage by DNA dioxygenases","",918.4,886.8,927.2,1064,1033.6,1287.4,0.8072082717872968,-0.3089871364919429,0.054815304883884364,1.2610981659936153,0.2439982115690078,0.6126133568930643,1642]
["Q6PD62","RNA polymerase-associated protein CTR9 homolog [OS=Homo sapiens]",14,15,24,15,1173,133.4,6.77,58.56,"cell-cell signaling;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","nucleus;other cell component","other molecular function","CTR9","ENSG00000198730","","E3 ubiquitin ligases ubiquitinate target proteins; RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex","Endoderm differentiation",2189.5,2047.8,2211.1,2809.9,2564.6,3508.2,0.7259504429959359,-0.4620570288760801,0.04760138648173061,1.3223803974350632,0.2290444593778598,0.6400802094138766,1519]
["Q6PGP7","Tetratricopeptide repeat protein 37 [OS=Homo sapiens]",26,38,67,38,1564,175.4,7.53,178.13,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","","TTC37","ENSG00000198677","RNA degradation","mRNA decay by 3' to 5' exoribonuclease","",6207.6,6275.1,6368.4,6128.1,5979.8,6596.4,1.0078484626529727,0.01127873545096484,0.810989242747119,0.09098490638878333,0.8722072359091662,0.05938031470181836,6796]
["Q6PII5-1","Hydroxyacylglutathione hydrolase-like protein [OS=Homo sapiens]",2,1,1,1,290,31.5,8.21,2.02,"","","other molecular function","HAGHL","ENSG00000103253","","","Orexin receptor pathway",178.9,199.5,214,201.9,185.8,367.2,0.784739700622599,-0.3497139057192944,0.40949471288365935,0.38775170118140184,0.5926726448448844,0.2271851174160903,5050]
["Q6PJG6-1","BRCA1-associated ATM activator 1 [OS=Homo sapiens]",23,12,25,12,821,88.1,5.27,67.16,"cell cycle OR cell proliferation;other metabolic processes;stress response;other biological processes","nucleus;other cell component","","BRAT1","ENSG00000106009","","","",1287.1,1343,1307.6,1502.1,1409,1604.8,0.871963506720698,-0.19766033806724945,0.030653057625450186,1.5135261983517845,0.18454958664284632,0.7338869232070504,1214]
["Q6PJI9-1","GATOR complex protein WDR59 [OS=Homo sapiens]",4,3,3,3,974,109.7,7.91,9.14,"stress response;other biological processes","other membranes;other cytoplasmic organelle;other cell component","","WDR59","ENSG00000103091","mTOR signaling pathway","Amino acids regulate mTORC1","",269.9,260.4,273.6,248.9,250.8,341,0.9562269537290352,-0.0645750225387596,0.7093739957450067,0.14912473595351206,0.8033490137744429,0.09509573513742521,6454]
["Q6Q0C0-1","E3 ubiquitin-protein ligase TRAF7 [OS=Homo sapiens]",2,1,1,1,670,74.6,7.15,3.82,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","TRAF7","ENSG00000131653","","Antigen processing: Ubiquitination & Proteasome degradation","",44.1,39.9,50.9,42.5,57.8,45.8,0.9233401779603013,-0.11506582985523055,0.5446292379517539,0.26389904764485084,0.6831465763153199,0.16548610385102794,5827]
["Q6QNY1","biogenesis of lysosome-related organelles complex 1 subunit 2 [OS=Homo sapiens]",21,1,3,1,142,16,4.86,11.69,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","BLOC1S2","ENSG00000196072","","","Genotoxicity pathway",45.1,47.5,46.3,83.3,114.1,26.1,0.6214765100671141,-0.6862282320892875,0.33564657912403945,0.4741177747419054,0.5503007731757749,0.2593998770021514,4458]
["Q6SZW1","Sterile alpha and TIR motif-containing protein 1 [OS=Homo sapiens]",8,4,6,4,724,79.3,6.55,17.3,"other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;other cell component","other molecular function","SARM1","ENSG00000004139","","","Regulation of toll-like receptor signaling pathway",334.9,327.4,345.2,316.3,305.4,528.7,0.8757823365785813,-0.1913557421366059,0.5489812918204123,0.26044245518123643,0.6871903171631091,0.16292296854855073,5839]
["Q6UW02","Cytochrome P450 20A1 [OS=Homo sapiens]",35,13,34,13,462,52.4,6.21,71.7,"","other membranes","other molecular function","CYP20A1","ENSG00000119004","","","Oxidation by cytochrome P450; Metapathway biotransformation Phase I and II",2989.7,3220,3195.6,2653.4,2775.9,2638.3,1.16581139372304,0.2213344065918451,0.006327588462519548,2.1987617744959764,0.08928251751458567,1.0492335723572364,518]
["Q6UWI2","Prostate androgen-regulated mucin-like protein 1 [OS=Homo sapiens]",7,1,3,1,310,32.3,4.68,13.41,"other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","","PARM1","ENSG00000169116","","","",85.9,104.5,78.5,123.1,111.3,254.9,0.5495605967708972,-0.8636495275601676,0.19057376743598173,0.7199368804126218,0.4317742300649691,0.3647432815815916,3226]
["Q6UWP7-1","Lysocardiolipin acyltransferase 1 [OS=Homo sapiens]",9,3,5,3,414,48.9,8.62,18.6,"other metabolic processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","LCLAT1","ENSG00000172954","Glycerolipid metabolism; Glycerophospholipid metabolism; Metabolic pathways","Synthesis of PA; Acyl chain remodeling of CL","",365.5,413.5,381.7,327,368.6,399,1.060387356111822,0.08459137295688479,0.431023467038319,0.3654990840671038,0.6059531680290583,0.2175609396167102,5199]
["Q6UXV4","MICOS complex subunit MIC27 [OS=Homo sapiens]",47,8,19,8,268,29.1,9.52,61.94,"cell organization and biogenesis","non-structural extracellular;other membranes;mitochondrion;other cell component","","APOOL","ENSG00000155008","","Platelet degranulation ; Cristae formation","",2148.6,2160.9,2110.6,1902.9,1916.6,1422.9,{"$f":"AVERAGE(S3842:U3842)/AVERAGE(V3842:X3842)","v":1.224649015717992},{"$f":"LOG(Y3842,2)","v":0.29236833221724634},{"$f":"TTEST(V3842:X3842,S3842:U3842,2,2)","v":0.0737259795986374},1.132379448257937,{"$f":"AA3842*7309/AE3842","v":0.27848226609118387},0.5552024557288942,1935]
["Q6V1X1","Dipeptidyl peptidase 8 [OS=Homo sapiens]",9,6,11,5,898,103.3,5.8,24.15,"protein metabolism;other biological processes","cytosol;other cell component","other molecular function","DPP8","ENSG00000074603","","","",384.4,369.9,385.2,426.3,409.7,484.3,0.8630614254336136,-0.21246485296304268,0.059865552271909615,{"$f":"-LOG10(AA3843)","v":1.222823006686788},0.2557319237611849,{"$f":"-LOG10(AC3843)","v":0.5922150543439153},1711]
["Q6Y1H2","Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 [OS=Homo sapiens]",9,2,10,2,254,28.4,9.55,22.85,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","HACD2","ENSG00000206527","Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism","Synthesis of very long-chain fatty acyl-CoAs","",1175.9,1244.3,1115.7,933.8,927,1353.2,1.100155569383945,0.13770754494028067,0.5024833160272204,0.2988783535643962,0.6565338857423944,0.18274285371593166,5594]
["Q6YHK3-1","CD109 antigen [OS=Homo sapiens]",2,2,2,2,1445,161.6,5.85,5.29,"developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol","enzyme regulator activity;other molecular function","CD109","ENSG00000156535","","Platelet degranulation ; Post-translational modification: synthesis of GPI-anchored proteins","",36.3,41.5,36.4,36.7,25.6,114.5,0.6459276018099547,-0.6305556240285889,0.4978252541625286,0.30292307585672373,0.6539548495100506,0.1844522352927596,5564]
["Q6ZMS4","Zinc finger protein 852 [OS=Homo sapiens]",18,7,10,3,543,62,8.12,25.13,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF852","ENSG00000178917; ENSG00000281626","","","",1273,1246.3,1251.4,1531.1,1638.5,658.2,0.9850828151941063,-0.021683078899534566,0.9540656597502678,0.02042173568797657,0.9695864720682296,0.01341345252917598,7192]
["Q6ZQN7","Solute carrier organic anion transporter family member 4C1 [OS=Homo sapiens]",5,2,2,2,724,78.9,7.53,6.93,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle","transporter activity","SLCO4C1","ENSG00000173930","","Neutrophil degranulation; Transport of organic anions","",94.6,101.7,108,117.3,143.8,202.2,0.6568098424347075,-0.6064523485186756,0.10499323064675226,0.9788387008113296,0.3306314186975925,0.4806558793832744,2321]
["Q6ZSR9","Uncharacterized protein FLJ45252 [OS=Homo sapiens]",15,4,6,4,355,38,5.26,18.58,"","","","","","","","",312.5,310.3,334.7,401.7,378.9,961.2,0.5497186818234011,-0.863234585648136,0.24202790960940232,0.6161345501746982,0.47926903043487445,0.3194206334863824,3691]
["Q6ZT07","TBC1 domain family member 9 [OS=Homo sapiens]",2,3,3,1,1266,143.1,5.31,4.78,"transport;other biological processes","","enzyme regulator activity;other molecular function","TBC1D9","ENSG00000109436","","","",59,51.7,56.4,68.7,77.2,94.5,0.6950915141430948,-0.5247251626499977,0.036276262163323136,1.4403774681795316,0.19625699493096138,0.7071748553175891,1351]
["Q6ZVF9","G protein-regulated inducer of neurite outgrowth 3 [OS=Homo sapiens]",23,13,20,13,776,82.4,7.56,69.33,"cell organization and biogenesis;developmental processes","plasma membrane;other membranes","","GPRIN3","ENSG00000185477","","","",1680.3,1646.8,1637.4,2739.6,2930.8,3050.3,0.5692776955978304,-0.8127955191013395,1.6460670855109014E-4,3.7835524690790976,0.020051840546665298,1.6978457575787684,60]
["Q6ZVK8-1","8-oxo-dGDP phosphatase NUDT18 [OS=Homo sapiens]",24,6,8,6,323,35.5,6.23,28.93,"other metabolic processes","cytosol","other molecular function","NUDT18","ENSG00000275074; ENSPTRG00000020049","","","",364.1,349.4,399,372.8,349.9,1518.9,0.49629728765167724,-1.0107235248023339,0.3849573369487708,0.4145873986847376,0.5777521921475495,0.23825839801539897,4870]
["Q70CQ3","ubiquitin carboxyl-terminal hydrolase 30 [OS=Homo sapiens]",2,1,1,1,517,58.5,8.27,2.23,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle","other molecular function","USP30","ENSG00000135093","Mitophagy","Ub-specific processing proteases; Pexophagy","",114.8,110.9,131.3,124.6,114.4,139.7,0.9426987060998151,-0.08513134696795742,0.49513880049956027,0.30527303977112824,0.6519491069809559,0.18578630521901593,5551]
["Q70IA6-1","MOB kinase activator 2 [OS=Homo sapiens]",8,2,5,2,237,26.9,6.79,14.96,"other metabolic processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","MOB2","ENSCATG00000043655; ENSCSAG00000009929; ENSG00000182208","","","",611.5,653.1,621.5,687.7,671.8,722.1,0.9060818601076094,-0.14228669821818093,0.028464566134075067,1.545695431455915,0.17873497755494389,0.7477904498858117,1164]
["Q71RC2","La-related protein 4 [OS=Homo sapiens]",8,5,8,5,724,80.5,6.61,23.37,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity","LARP4","ENSG00000161813","","","",722.8,693.4,733.9,1382.8,1445.9,1287.4,0.5223634022497022,-0.9368742723568296,1.616723124929349E-4,3.7913643496738065,0.02002818528831968,1.6983583994319775,59]
["Q76I76","Protein phosphatase Slingshot homolog 2 [OS=Homo sapiens]",3,2,2,2,1423,158.1,5.41,7.71,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SSH2","ENSG00000141298","Axon guidance; Regulation of actin cytoskeleton","","Regulation of actin cytoskeleton",100.2,91.7,104.5,90,90.1,236.6,0.7113030957523397,-0.491463652396715,0.4590508723542736,0.33813918296277423,0.624456137360392,0.20449806164749523,5373]
["Q7L014","probable ATP-dependent RNA helicase DDX46 [OS=Homo sapiens]",46,46,192,45,1031,117.3,9.29,604.08,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus","other molecular function","DDX46","ENSG00000145833","Spliceosome","mRNA Splicing - Major Pathway","",22397.6,22782.2,23762,22540.3,22738.4,19559.7,1.0632865709209358,0.08853047619944701,0.2836430427831347,0.547227864374792,0.5171232226744653,0.28640595874134067,4009]
["Q7L0Y3","Mitochondrial ribonuclease P protein 1 [OS=Homo sapiens]",38,16,56,16,403,47.3,9.36,174.21,"RNA metabolism OR transcription;other metabolic processes;other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","TRMT10C","ENSG00000174173","","tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion","",7947.6,7931.9,8102.3,6857,7254.7,5249.9,1.23862697297744,0.3087417683787058,0.06653902391248248,1.1769235742596813,0.2669230108541902,0.5736139850126877,1822]
["Q7L2J0-1","7SK snRNA methylphosphate capping enzyme [OS=Homo sapiens]",30,13,34,13,689,74.3,9.57,115.51,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MEPCE","ENSG00000146834","","","IL-18 signaling pathway",2140.9,2237.5,2157.4,2596.3,2620.8,3753.8,0.7285556633113732,-0.4568888932009375,0.10140643186041957,0.9939344983271272,0.32536418369965175,0.48763025618623573,2278]
["Q7L2Z9","Centromere protein Q [OS=Homo sapiens]",15,3,5,3,268,30.6,9.42,19.29,"cell cycle OR cell proliferation;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","","CENPQ","ENSG00000031691","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Deposition of new CENPA-containing nucleosomes at the centromere","",285.7,268.5,264.9,290.6,318.1,302.2,0.8992205511033043,-0.15325308709096175,0.0403315638845742,1.39435493759385,0.20788674219488917,0.6821732065569246,1418]
["Q7L5D6","Golgi to ER traffic protein 4 homolog [OS=Homo sapiens]",20,7,23,7,327,36.5,5.41,65.88,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","GET4","ENSG00000239857","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",1672.5,1728.1,1788.8,1651.8,1477.8,1927.7,1.026120657267712,0.03720038143930743,0.7610138887704816,0.11860741713042736,0.8384459621681415,0.07652492242991786,6634]
["Q7L8L6","FAST kinase domain-containing protein 5, mitochondrial [OS=Homo sapiens]",7,4,8,4,764,86.5,8.13,30.2,"RNA metabolism OR transcription;other metabolic processes;other biological processes","mitochondrion;other cell component","nucleic acid binding activity","FASTKD5","ENSG00000215251","","","",493.1,515.5,516.9,470,491.7,657.8,0.9419573942574868,-0.08626628821653047,0.6280699513348522,0.20199198399065899,0.7458266895705012,0.1273620793740211,6155]
["Q7LBC6-1","Lysine-specific demethylase 3B [OS=Homo sapiens]",14,15,21,15,1761,191.5,7.18,59.58,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KDM3B","ENSG00000120733","Thermogenesis","HDMs demethylate histones","Thermogenesis",1087.8,1136.7,1120.8,1460.1,1442.7,1951.7,0.6891131939437636,-0.537187114964499,0.03978271154273313,1.4003056192027008,0.20680785111368166,0.684432978002533,1406]
["Q7Z2E3-4","Isoform 4 of Aprataxin [OS=Homo sapiens]",33,7,22,7,254,29.1,8.59,61.07,"","","","APTX","","","","",1715.7,1673.2,1681.9,1682.1,1633.9,1614.5,1.028455531893317,0.040479416318943306,0.12216578620907231,0.913050405722756,0.35362761639687507,0.4514538262934632,2525]
["Q7Z2Z1","Treslin [OS=Homo sapiens]",0,1,2,1,1910,210.7,8.78,0,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","TICRR","ENSG00000140534","","","",72.8,70.7,74.9,88.5,92.2,69.6,0.8725529364762286,-0.19668543476847938,0.20872818507723412,0.6804189031289066,0.44962991592381496,0.3471448008900514,3393]
["Q7Z392","trafficking protein particle complex subunit 11 [OS=Homo sapiens]",8,8,9,8,1133,128.8,7.14,27.94,"cell organization and biogenesis;transport;other biological processes","cytosol;ER/Golgi;other cell component","","TRAPPC11","ENSG00000168538","","RAB GEFs exchange GTP for GDP on RABs","Genes related to primary cilium development (based on CRISPR)",588.8,583.8,666.1,610.9,579.4,871.1,0.8919666246240419,-0.16493836612094445,0.48334832787320753,0.3157397794952063,0.6433787886405524,0.19153326132061024,5491]
["Q7Z3K3-1","Pogo transposable element with ZNF domain [OS=Homo sapiens]",11,13,34,13,1410,155.2,7.4,119.03,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","POGZ","ENSG00000143442; ENSPTRG00000001289","","","",2757.3,2695.8,2947.6,2664,2700.4,2824.5,1.0258642796956858,0.036839877181192145,0.476751931858218,0.3217075384630495,0.6382014413830981,0.19504221928381374,5460]
["Q7Z3K6-1","Mesoderm induction early response protein 3 [OS=Homo sapiens]",5,2,2,2,550,61.4,4.51,6.44,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","MIER3","ENSG00000155545; ENSGGOG00000015237","","","",21,15.7,27.3,33.8,30,25,0.7207207207207207,-0.47248777146274373,0.12113644735012871,0.9167251673316223,0.35176253225351245,0.4537504209960121,2517]
["Q7Z434","Mitochondrial antiviral-signaling protein [OS=Homo sapiens]",40,11,31,11,540,56.5,5.52,126.96,"stress response;signal transduction;other biological processes","other membranes;mitochondrion;other cytoplasmic organelle","other molecular function","MAVS","ENSG00000088888","NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; Hepatitis C; Hepatitis B; Measles; Influenza A; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease","Ovarian tumor domain proteases; TRAF6 mediated NF-kB activation; Negative regulators of DDX58/IFIH1 signaling; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10","Novel intracellular components of RIG-I-like receptor (RLR) pathway; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation",1265.9,1315.5,1269.5,1411.2,1440.1,2001.7,0.7935091695858232,-0.3336812003214749,0.1583118906254863,0.8004864645495334,0.3961320125236835,0.4021600596391102,2921]
["Q7Z4G4","tRNA (guanine(10)-N2)-methyltransferase homolog [OS=Homo sapiens]",3,2,2,2,463,53.4,7.78,4.86,"RNA metabolism OR transcription;other metabolic processes","other cell component","nucleic acid binding activity;other molecular function","TRMT11","ENSG00000066651","","tRNA modification in the nucleus and cytosol","",315.3,329.4,359.1,352.9,323.1,356.1,0.9725801763395021,-0.04011090880957531,0.6011679978967284,0.22100414635988022,0.7249524660331939,0.13969046848591732,6061]
["Q7Z4H8","KDEL motif-containing protein 2 [OS=Homo sapiens]",2,1,1,1,507,58.5,8.24,0,"protein metabolism;other metabolic processes","ER/Golgi;other cell component","other molecular function","POGLUT3","ENSG00000178202","","","",168.1,183.3,152.1,197.2,201.5,103.9,1.001790688420215,2.5811070134917576E-3,0.9932005746752117,0.002963037830520893,0.9951066484305857,0.00213037217601833,7295]
["Q7Z5D8","NANOG neighbor homeobox [OS=Homo sapiens]",4,1,1,1,188,22.7,9.72,2.13,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NANOGNB","ENSG00000205857","","","Pre-implantation embryo",69.5,63.5,72.1,69,80.4,135.7,0.719396702911259,-0.4751405474581011,0.2682013483023217,0.5715390431928973,0.5043178941964674,0.2972956219401907,3887]
["Q7Z5U6","WD repeat-containing protein 53 [OS=Homo sapiens]",13,2,2,2,358,39,6.52,11.19,"","","","WDR53","ENSG00000185798","","","3q29 copy number variation syndrome",87.5,81.6,74,83.5,87.3,141.8,0.7776711452335252,-0.3627678849709357,0.2947828570621871,0.5304977762396278,0.5252481477980315,0.27963547038800235,4102]
["Q7Z5W3","Pre-miRNA 5'-monophosphate methyltransferase [OS=Homo sapiens]",3,1,1,1,292,33.2,6.7,2.56,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","BCDIN3D","ENSG00000186666","","MicroRNA (miRNA) biogenesis","",79.6,78.3,74.9,102.2,111.6,105.9,0.7281826712543008,-0.4576276858722367,7.0536294235421242E-4,3.1515873605940095,0.03414236917660224,1.466706346003206,151]
["Q7Z6K3","Protein prenyltransferase alpha subunit repeat-containing protein 1 [OS=Homo sapiens]",4,1,1,1,402,46.4,6.99,2.39,"protein metabolism;other metabolic processes","other cell component","other molecular function","PTAR1","ENSG00000188647","","","",89.1,89.1,105.7,116,103.8,96,0.8989867004433185,-0.15362832213584537,0.25605888129216625,0.5916601562510327,0.4923794694460519,0.3077000639701636,3801]
["Q7Z6L1-1","Tectonin beta-propeller repeat-containing protein 1 [OS=Homo sapiens]",9,6,7,6,1165,129.6,6.24,25,"cell organization and biogenesis;other metabolic processes","other membranes;nucleus;other cytoplasmic organelle;other cell component","other molecular function","TECPR1","ENSG00000205356","Shigellosis","","",335.8,345.5,322.3,298,373.1,370.7,0.9633326934152429,-0.05389396634152974,0.644315793409739,0.1909012231366028,0.7562717414536345,0.12132212697402983,6227]
["Q7Z7A3","Cytoplasmic tRNA 2-thiolation protein 1 [OS=Homo sapiens]",10,2,3,2,348,36.4,9.2,9.81,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol","nucleic acid binding activity;other molecular function","CTU1","ENSG00000142544","Sulfur relay system","tRNA modification in the nucleus and cytosol","",260.1,267.5,257.2,319.8,318.2,540.9,0.6657053185172617,-0.5870444004666022,0.1506529050018804,0.8220224895191824,0.3882658965651423,0.4108707541462384,2836]
["Q7Z7H8","39S ribosomal protein L10, mitochondrial [OS=Homo sapiens]",33,5,16,5,261,29.3,9.58,50.63,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus;other cell component","other molecular function","MRPL10","ENSG00000159111","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1282,1318.4,1404.4,1131.5,1042.9,1058.3,1.2388405976428374,0.3089905669904811,0.004786799378467486,2.3199547740326416,0.07622378356692561,1.1179094976859298,459]
["Q7Z7L1","Schlafen family member 11 [OS=Homo sapiens]",21,12,30,10,901,102.8,7.77,80.77,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SLFN11","ENSG00000172716","","","",2431.2,2321.3,2306.4,2455.9,2255.5,2785.8,0.9415381742517207,-0.08690850542527735,0.4115760173960281,0.38554993958506045,0.5932181248565508,0.22678558824896075,5071]
["Q86TG7-1","Retrotransposon-derived protein PEG10 [OS=Homo sapiens]",22,12,39,4,708,80.1,6.39,131.72,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PEG10","ENSG00000242265","","","",3461.9,3313,3345.4,1321.2,1361.4,2135.8,2.1003445127013114,1.0706259878916988,2.7742332378313354E-3,2.5568570293316,0.06016875589112532,1.220628968318966,337]
["Q86TU7","Histone-lysine N-methyltransferase setd3 [OS=Homo sapiens]",15,8,12,8,594,67.2,5.96,42.46,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","cytoskeletal activity;other molecular function","SETD3","ENSG00000183576","","PKMTs methylate histone lysines","Histone modifications",1109.8,1061.1,1104.7,1100.7,1092,1005.9,1.0240730319514786,0.03431860506169284,0.49199284469572685,0.3080412133541013,0.6497968380703049,0.18722240627506154,5534]
["Q86U38","Nucleolar protein 9 [OS=Homo sapiens]",16,9,15,9,636,69.4,7.28,32,"RNA metabolism OR transcription;other metabolic processes;transport","nucleus;other cell component","","NOP9","ENSG00000196943; ENSG00000285326","","","",932.8,969,905.1,1059.3,1056.1,1537.4,0.7684242225142357,-0.3800250980723982,0.15471252895153204,0.8104745147803595,0.3925004769547892,0.40615981117679945,2881]
["Q86UD5","Sodium/hydrogen exchanger 9B2 [OS=Homo sapiens]",3,1,1,1,537,57.5,6.71,2.37,"transport;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle","transporter activity;other molecular function","SLC9B2","ENSG00000164038","","Stimuli-sensing channels","",34.7,22.1,33.7,31.7,38.2,54,0.7304277643260694,-0.45318649017003393,0.2246154255314431,0.6485604217471108,0.4663960639799198,0.3312451233412688,3520]
["Q86UF1","Tetraspanin-33 [OS=Homo sapiens]",5,1,2,1,283,31.5,7.17,7.59,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","TSPAN33","ENSG00000158457","","Amyloid fiber formation","",57.4,54.8,45.8,57.5,46.6,26.1,1.2135176651305684,0.2791951098988298,0.40019929553876804,0.3977236801773062,0.5865363246626941,0.23170508651169627,4987]
["Q86UV5","Ubiquitin carboxyl-terminal hydrolase 48 [OS=Homo sapiens]",15,11,20,11,1035,119,6.05,67.89,"protein metabolism;other metabolic processes","cytosol;mitochondrion;nucleus","other molecular function","USP48","ENSG00000090686","","Ub-specific processing proteases","",1994.1,2006.9,2011.9,2196.3,2182.8,1684.5,0.9916386305165248,-0.012113620387850781,0.924925136588894,0.03389341761998949,0.950144458654705,0.02221036015631967,7115]
["Q86V42","Protein FAM124A [OS=Homo sapiens]",1,1,1,1,546,60.1,6.6,1.79,"","","","FAM124A","ENSG00000150510","","","",295.7,270.4,259.8,282.5,293.6,311.3,0.9306964164976333,-0.10361744250350682,0.20498087477833865,0.6882866578013422,0.446159980272447,0.35050938771939927,3358]
["Q86V85","Integral membrane protein GPR180 [OS=Homo sapiens]",5,2,3,2,440,49.4,7.39,6.67,"signal transduction;other biological processes","other membranes","","GPR180","ENSG00000152749","","","",106.1,123,125.5,108.7,99,951.6,0.3058742344518244,-1.7089895093842948,0.3963804134668056,0.4018878136555967,0.5850453235114867,0.2328104877836853,4952]
["Q86VQ1","Glucocorticoid-induced transcript 1 protein [OS=Homo sapiens]",20,8,12,8,547,58,9.44,39.59,"","other cell component","","GLCCI1","ENSG00000106415","","","",1171.8,1113.2,1225.4,1477.9,1567,2213.3,0.6676048838005401,-0.5829335862487917,0.0674795355342492,1.1708279153479808,0.2684855335981641,0.5710791097698161,1837]
["Q86VX9","Vacuolar fusion protein MON1 homolog A [OS=Homo sapiens]",12,4,4,4,555,62.1,6.3,15.8,"","","","","","","","",137.2,127.8,166.3,130,142.8,140.6,1.0432994678277698,0.061153327309053124,0.6515359091395695,0.18606164332607483,0.760350624285664,0.11898609314340965,6263]
["Q86W56","Poly(ADP-ribose) glycohydrolase [OS=Homo sapiens]",17,12,21,12,976,111,6.43,67.22,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","PARG","ENSG00000227345","","POLB-Dependent Long Patch Base Excision Repair","",1156.1,1107,1167.5,1229.4,1247.5,1182.3,0.9375273283777874,-0.09306735005497606,0.04707493213824398,1.3272102973762454,0.22771057511477516,0.6426167998312977,1511]
["Q86WN1-1","F-BAR and double SH3 domains protein 1 [OS=Homo sapiens]",9,6,7,6,690,76.9,5.34,16.03,"cell-cell signaling;cell organization and biogenesis","cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","FCHSD1","ENSG00000197948","","","",908.5,898.8,891.4,891.6,933.5,1271.5,0.8715042304462959,-0.19842042740492907,0.3323266210270578,0.47843486816432296,0.547930357114091,0.2612746375796845,4433]
["Q86WU2","Probable D-lactate dehydrogenase, mitochondrial [OS=Homo sapiens]",3,1,1,1,507,54.8,6.65,3.44,"other metabolic processes","other membranes;mitochondrion","other molecular function","LDHD","ENSG00000166816","Pyruvate metabolism; Metabolic pathways","Mitochondrial protein import","Clear cell renal cell carcinoma pathways",53.1,41.2,50.4,50.7,55.8,70.2,0.818902093944539,-0.28823711801989194,0.1949606438828831,0.7100530495069526,0.43523743009773747,0.36127376269890227,3274]
["Q86X95","Corepressor interacting with RBPJ 1 [OS=Homo sapiens]",8,4,5,4,450,52.3,9.86,9.3,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","CIR1","ENSG00000138433","Notch signaling pathway; Epstein-Barr virus infection","","Notch signaling pathway (Netpath)",256.3,248.6,279.8,367,392,259.9,0.7701442732358426,-0.37679935974900036,0.1337157781175574,0.873817344083608,0.36894247725980633,0.43304134049686605,2649]
["Q86Y07","serine/threonine-protein kinase VRK2 [OS=Homo sapiens]",6,3,5,3,508,58.1,8.84,10.03,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;mitochondrion;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","VRK2","ENSG00000028116","","RAC1 GTPase cycle; RAC3 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOD GTPase cycle","",260.8,272,235.6,254.3,270.1,312.7,0.9179309520965236,-0.1235424584753157,0.3264143665822643,0.4862307347524522,0.5453171669370902,0.2633508302268113,4375]
["Q86Y39-1","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [OS=Homo sapiens]",26,2,4,2,141,14.8,8.72,13.78,"cell organization and biogenesis","other membranes;mitochondrion","","NDUFA11","ENSG00000174886; ENSPPAG00000024786; ENSPTRG00000029161","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Nonalcoholic fatty liver disease; Oxidative phosphorylation",225.9,248.4,242.5,321.1,307.5,217.2,0.8474816741546464,-0.23874592297119782,0.26607863195938264,0.5749900010395383,0.5021349653992068,0.29917953614164805,3873]
["Q86YB8","ERO1-like protein beta [OS=Homo sapiens]",11,5,8,3,467,53.5,7.99,22.85,"other biological processes","other membranes;ER/Golgi","other molecular function","ERO1B","ENSG00000086619","Protein processing in endoplasmic reticulum","Insulin processing","",280.3,244.1,277.4,230.3,251.9,367,0.9441827602449364,-0.08286195375460705,0.7376128837290381,0.13217150615784212,0.8227090748016999,0.08475371223000785,6553]
["Q86YS6","Ras-related protein Rab-43 [OS=Homo sapiens]",39,7,20,6,212,23.3,5.64,58.4,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","RAB43","ENSG00000172780","","Retrograde transport at the Trans-Golgi-Network; RAB geranylgeranylation","",1563.5,1653,1632.8,1512.7,1567.4,1057.6,1.1719796021944557,0.2289474604862773,0.22126573457452153,0.6550858361288243,0.4631246431859043,0.33430210927838344,3492]
["Q86YV0","RAS protein activator like-3 [OS=Homo sapiens]",38,35,96,33,1011,111.8,8.75,290.2,"signal transduction;other biological processes","other membranes;cytosol;other cell component","enzyme regulator activity;other molecular function","RASAL3","ENSG00000105122","Ras signaling pathway","Regulation of RAS by GAPs","Ras signaling",10620.5,10603.1,10874.3,11074.1,10704.5,15522.9,0.8604989075506346,-0.21675473419920172,0.3259667653393197,0.4868266771269158,0.5454420988702123,0.26325134493962365,4368]
["Q8IU85-1","calcium/calmodulin-dependent protein kinase type 1D [OS=Homo sapiens]",29,11,29,8,385,42.9,7.21,95.13,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","kinase activity;other molecular function","CAMK1D","ENSCATG00000031901; ENSG00000183049; ENSGGOG00000016547; ENSMMUG00000011956; ENSMNEG00000040028; ENSPPYG00000002093; ENSPTRG00000002296; ENSRBIG00000041279; ENSRROG00000039467","Calcium signaling pathway; Oxytocin signaling pathway; Aldosterone synthesis and secretion; Glioma","","",3523,3492,3365.3,3671.2,3658.7,3088,0.9963908273260446,-0.005216354553233036,0.9526380921305758,0.021072056803684194,0.9684049812771041,0.013942985302593868,7190]
["Q8IUC8-1","Polypeptide N-acetylgalactosaminyltransferase 13 [OS=Homo sapiens]",3,2,2,1,556,64,6.83,4.33,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","GALNT13","ENSG00000144278; ENSGGOG00000034959; ENSMFAG00000043213; ENSMMUG00000055468; ENSPPAG00000035152; ENSPPYG00000012857; ENSPTRG00000012546","Mucin type O-glycan biosynthesis; Other types of O-glycan biosynthesis; Metabolic pathways","O-linked glycosylation of mucins","",121.2,106.5,120.2,109.7,130.6,110,0.9931487296602911,-0.009918309182172744,0.9285928512430819,0.03217466406595995,0.9524396786045025,0.021162520196983798,7126]
["Q8IUR0","Trafficking protein particle complex subunit 5 [OS=Homo sapiens]",32,5,14,5,188,20.8,9.66,29.55,"transport","cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","TRAPPC5","ENSG00000181029","","RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport","",1185,1279.1,1174.6,1397.6,1278.5,743.8,1.0639784789028919,0.08946896973564568,0.7384959597104694,0.1316518763577843,0.8230660215803327,0.0845653268071577,6558]
["Q8IV36","protein HID1 [OS=Homo sapiens]",3,2,2,2,788,88.7,6.06,5.21,"","other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","","HID1","ENSG00000167861","","","",134.7,141.2,129.9,181.7,155,280,0.6580184854872708,-0.603799981221359,0.1391360144530839,0.8565604411524641,0.3751180854435966,0.42583199684897666,2711]
["Q8IV53-1","DENN domain-containing protein 1C [OS=Homo sapiens]",11,5,11,5,801,87,5.67,41.56,"transport","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","DENND1C","ENSG00000205744","","RAB GEFs exchange GTP for GDP on RABs","",615.8,626.2,620.1,622.4,643,821.5,0.8922804159279313,-0.16443091939145726,0.30194639437925114,0.5200701520485255,0.5300014881167019,0.275722911003051,4164]
["Q8IVH4","methylmalonic aciduria type A protein, mitochondrial [OS=Homo sapiens]",10,4,5,4,418,46.5,9.29,14.05,"other metabolic processes","mitochondrion;other cell component","other molecular function","MMAA","ENSG00000151611","","Cobalamin (Cbl, vitamin B12) transport and metabolism; Propionyl-CoA catabolism; Defective MMAA causes MMA, cblA type; Defective MUT causes MMAM","",430.7,426.9,436.7,393.4,367.8,481.8,1.0412711182622687,0.058345755521952675,0.6475319821630408,0.18873877653796814,0.7584633425688566,0.12006540433641913,6240]
["Q8IW19","Aprataxin and PNK-like factor [OS=Homo sapiens]",5,2,2,2,511,56.9,5.08,6.3,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","APLF","ENSG00000169621","","","",81.5,80.5,72.1,46.5,67.9,49,1.4326805385556916,0.5187169509663294,0.03316174850299009,1.4793625786893,0.19025056499870846,0.7206740448046589,1274]
["Q8IW50","Protein FAM219A [OS=Homo sapiens]",9,1,2,1,185,20.4,4.73,6.09,"","","","FAM219A","ENSG00000164970","","","",163.8,176.5,184.7,178.8,195.6,109.2,1.08560794044665,0.11850317819172375,0.6378602464505604,0.19527446366729223,0.7524403714181965,0.12352791087048767,6196]
["Q8IWD4-1","Coiled-coil domain-containing protein 117 [OS=Homo sapiens]",11,3,3,3,279,30.5,5.07,4.93,"","","","CCDC117; FLJ33814","ENSG00000159873","","","",186.1,171.7,162.2,258.9,274.9,282.1,0.6373330064958942,-0.6498807172459155,5.3970209922454165E-4,{"$f":"-LOG10(AA4227)","v":3.2678458927002825},0.030817833150251366,{"$f":"-LOG10(AC4227)","v":1.5111979004641778},128]
["Q8IWJ2","GRIP and coiled-coil domain-containing protein 2 [OS=Homo sapiens]",30,44,73,43,1684,195.8,5.14,202.13,"cell organization and biogenesis;transport;other biological processes","cytosol;ER/Golgi;nucleus","other molecular function","GCC2","ENSG00000135968","Salmonella infection","Signaling by ALK fusions and activated point mutants; Retrograde transport at the Trans-Golgi-Network","Deregulation of Rab and Rab effector genes in bladder cancer",6384.5,6031.9,6325,7271.3,7332,7336.7,0.8542114858705562,-0.22733479805799178,6.5654961431066178E-4,3.1827324494569385,0.03309462848963191,1.4802424898079405,145]
["Q8IWU5-1","Extracellular sulfatase Sulf-2 [OS=Homo sapiens]",7,5,7,5,870,100.4,9.17,19.82,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","SULF2","ENSG00000196562","","","",499,484.9,470.6,518,512.9,668.6,0.8558399529273315,-0.22458706544136556,0.18951210701484417,0.72236303982899,0.4315090312060735,0.36501011034988917,3210]
["Q8IWY9","Codanin-1 [OS=Homo sapiens]",5,3,5,3,1227,134,6.77,18.73,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","","CDAN1","ENSG00000140326","","","",218,190.4,235.5,201.2,174.2,1192.8,0.41059813799260303,-1.284201009854215,0.41025807833226013,0.38694285856108035,0.592838334229041,0.22706372168549332,5058]
["Q8IWZ8-1","SURP and G-patch domain-containing protein 1 [OS=Homo sapiens]",9,5,9,5,645,72.4,7.61,25.73,"RNA metabolism OR transcription;other metabolic processes","nucleus","","SUGP1","ENSG00000105705","","mRNA Splicing - Major Pathway","mRNA processing",763.3,609.5,824.7,854.1,739.9,941.6,0.866658778987222,-0.206464007737968,0.26320691463245266,0.5797027056839448,0.49877607960814013,0.30209438266601374,3857]
["Q8IXH7","Negative elongation factor C/D [OS=Homo sapiens]",25,11,27,11,590,66.2,5.1,83.75,"other biological processes","nucleus","nucleic acid binding activity","NELFCD","ENSG00000101158","","RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat","Initiation of transcription and translation elongation at the HIV-1 LTR",2330.4,2336.9,2378.8,2418.7,2348.7,1712.3,1.0874114542339923,0.12089792993758439,0.44904127308249825,0.3477137395129515,0.6169253129624023,0.20976740992402665,5320]
["Q8IXS8","protein FAM126B [OS=Homo sapiens]",3,2,2,2,530,58.6,7.9,3.57,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol","","FAM126B","ENSG00000155744","","","",134.2,151.3,166.4,157.7,148.1,108.1,1.091809615849239,0.12672130844071283,0.5162309633520542,0.28715595018027323,0.6661603303566674,0.17642123297801285,5664]
["Q8IXW5","Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 [OS=Homo sapiens]",14,7,8,7,612,69.5,7.78,26.92,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","RPAP2","ENSG00000122484","","RNA polymerase II transcribes snRNA genes","",659.9,662.8,664.5,836.7,786.7,879.1,0.7940859140859141,-0.3326329903902368,0.003018440634302814,2.5202173612874796,0.06339592700034273,1.1979386433500876,348]
["Q8IY63-1","Angiomotin-like protein 1 [OS=Homo sapiens]",1,1,1,1,956,106.5,7.11,0,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","AMOTL1","ENSG00000166025","Tight junction","Signaling by Hippo","",108.2,105.9,133.9,148.7,150.8,161,0.755700325732899,-0.4041138502426073,0.018334501214865243,1.736730900406307,0.14550148683979375,0.837132568719183,921]
["Q8IY95","transmembrane protein 192 [OS=Homo sapiens]",12,3,11,3,271,30.9,7.99,29.51,"","other membranes;nucleus;other cytoplasmic organelle;other cell component","other molecular function","TMEM192","ENSG00000170088","","","",1749,1748.7,1678.4,1533.9,1651.9,1091,1.2102740366629254,0.27533374714654196,0.1569498154796622,0.8042391905482753,0.3947509295735894,0.4036768386263051,2906]
["Q8IYD1","eukaryotic peptide chain release factor GTP-binding subunit ERF3B [OS=Homo sapiens]",32,17,60,5,628,68.8,5.43,148.61,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","GSPT2","ENSG00000189369","mRNA surveillance pathway","Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Translation factors",259.6,291.6,279.7,296.8,291.9,319.8,0.9145844799119429,-0.12881165742196712,0.1112580723110654,0.9536684690394451,0.3379822321369813,0.4711061301592981,2406]
["Q8IYS1","Peptidase M20 domain-containing protein 2 [OS=Homo sapiens]",51,17,62,16,436,47.7,5.85,200.63,"protein metabolism;other biological processes","nucleus","other molecular function","PM20D2","ENSG00000146281","","","",7539.9,7742.5,7377.8,7518.8,7594,8671.3,0.9527457419032044,-0.06983683965769466,0.3877585821882085,0.41143858124940674,0.5801693914459808,0.23644518742022566,4885]
["Q8IYU8","calcium uptake protein 2, mitochondrial [OS=Homo sapiens]",12,4,5,4,434,49.6,9.09,13.56,"transport;other biological processes","other membranes;mitochondrion","other molecular function","MICU2","ENSG00000165487","","Processing of SMDT1","",308.3,305.1,323.3,322.9,277.7,225.7,1.133607648553794,0.18092139739591834,0.2681365489743182,0.5716439844654151,0.5045854882732471,0.29706524381740934,3884]
["Q8IZ81","ELMO domain-containing protein 2 [OS=Homo sapiens]",29,8,34,8,293,34.9,8.05,93.22,"stress response;other biological processes","","enzyme regulator activity","ELMOD2","ENSG00000179387","","","Lung fibrosis",3267.8,3391.3,3522.4,2962.8,2803.5,1942,1.3208489550225082,0.40146549739541454,0.06446643319084407,1.1906663578389416,0.2622065443471782,0.5813564730639424,1797]
["Q8IZN3-1","Probable palmitoyltransferase ZDHHC14 [OS=Homo sapiens]",2,1,1,1,488,53.4,8.24,1.87,"protein metabolism;other metabolic processes;transport","other membranes;ER/Golgi","other molecular function","ZDHHC14","ENSG00000175048; ENSGGOG00000012728; ENSPPYG00000017128","","","",29.1,31.4,37.1,34.8,28.9,36.3,0.9759999999999999,-0.03504694709920096,0.8192821016620642,0.0865665327938542,0.877382107113264,0.05681122662267489,6825]
["Q8IZT6-1","Abnormal spindle-like microcephaly-associated protein [OS=Homo sapiens]",3,8,10,8,3477,409.5,10.45,29.69,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","other molecular function","ASPM","ENSG00000066279","","","",668.2,658.5,658.7,638.8,603.1,725.2,1.0093030349245082,0.013359396788511205,0.8749990295997129,0.05799242862308519,0.9145385252887605,0.03879799497935134,6993]
["Q8N0X7","Spartin [OS=Homo sapiens]",1,1,1,1,666,72.8,5.91,1.7,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;other cell component","other molecular function","SPART","ENSG00000133104","Endocytosis","","",72.7,76.6,81.9,101.9,97.9,144.9,0.6707281694226863,-0.5761999008665909,0.06848951537372248,1.1643759068118973,0.2692791112783957,0.569797334699823,1859]
["Q8N0Z8","tRNA pseudouridine synthase-like 1 [OS=Homo sapiens]",10,3,5,3,303,33.2,9.85,13.95,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","PUSL1","ENSG00000169972","","","",304.2,357.2,321.2,293.3,273.7,457.8,0.9588212334113974,-0.06066623659062832,0.8273598119169642,0.082305578299807,0.882927853015198,0.05407478262573171,6849]
["Q8N141","Zinc finger protein 82 homolog [OS=Homo sapiens]",1,1,1,1,532,62.5,8.98,2.89,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZFP82","ENSG00000181007","Herpes simplex virus 1 infection","","",132.8,147,153.7,221.5,210.4,70.4,0.8630300617161061,-0.21251728156263183,0.6641986837570277,0.17770198937844373,0.7699648183315013,0.11352911840357117,6305]
["Q8N1G4","Leucine-rich repeat-containing protein 47 [OS=Homo sapiens]",42,21,77,21,583,63.4,8.28,235.75,"","","other molecular function","LRRC47","ENSG00000130764","","","",7252.1,7117.2,7472.1,7737.4,7529.8,7690.3,0.9513840792769248,-0.0719002118409465,0.037143286728492486,1.4301196691236528,0.19845049904864884,0.7023478046237773,1368]
["Q8N1S5-1","zinc transporter zip11 [OS=Homo sapiens]",10,2,4,2,342,35.4,5.6,13.38,"transport","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","transporter activity","SLC39A11","ENSG00000133195","Alzheimer disease; Parkinson disease","","Nuclear receptors meta-pathway; NRF2 pathway; Zinc homeostasis",104.3,107.9,114.9,80.8,81.7,137.4,1.0906968989663224,0.1252502372140384,0.6577232910457338,0.18195677879827682,0.7658594128171529,0.11585094556501459,6277]
["Q8N2K1-1","Ubiquitin-conjugating enzyme E2 J2 [OS=Homo sapiens]",5,1,1,1,259,28.9,8.4,4.48,"protein metabolism;other metabolic processes;stress response","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","UBE2J2","ENSG00000160087","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum; Parkinson disease; Pathways of neurodegeneration","Antigen processing: Ubiquitination & Proteasome degradation; E3 ubiquitin ligases ubiquitinate target proteins","Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway",88.3,82,81.5,128.6,135.8,173.8,{"$f":"AVERAGE(S4354:U4354)/AVERAGE(V4354:X4354)","v":0.5746234596074852},{"$f":"LOG(Y4354,2)","v":-0.799311201271206},{"$f":"TTEST(V4354:X4354,S4354:U4354,2,2)","v":0.011890892268860571},1.9247855555660633,{"$f":"AA4354*7309/AE4354","v":0.11873023441680589},0.9254386747404824,732]
["Q8N3C0","Activating signal cointegrator 1 complex subunit 3 [OS=Homo sapiens]",22,36,65,36,2202,251.3,7.09,177.2,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","cytosol;nucleus","other molecular function","ASCC3","ENSG00000112249","","ALKBH3 mediated reversal of alkylation damage","Mesodermal commitment pathway; VEGFA-VEGFR2 signaling pathway",6698.5,6922.9,6970.6,7283.3,6674.8,6988.6,0.9830665450882478,-0.024639017060663487,0.5764400901786186,0.23924582255289292,0.7076252299488618,0.15019669097962596,5954]
["Q8N3F8","MICAL-like protein 1 [OS=Homo sapiens]",8,6,7,6,863,93.4,7.25,21.62,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;other cytoplasmic organelle","other molecular function","MICALL1","ENSG00000100139","","","",775.7,776.7,772.4,846,838.7,786.6,0.9407194593938413,-0.08816354715680301,0.059746224331016104,1.223689534798507,0.25552086227934273,0.5925736356352708,1709]
["Q8N3Z6","Zinc finger CCHC domain-containing protein 7 [OS=Homo sapiens]",9,4,4,4,543,63,7.33,7.63,"","cytosol;nucleus","other molecular function","ZCCHC7","ENSG00000147905","RNA degradation","","",115.7,88.3,93.5,96.9,121.3,182.9,0.7417102966841186,-0.4310722977318409,0.2690354065322651,0.5701905607050192,0.504976832651342,0.2967285460050591,3894]
["Q8N488","RING1 and YY1-binding protein [OS=Homo sapiens]",30,5,8,5,228,24.8,9.63,24.08,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RYBP","ENSG00000163602","","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Transcriptional Regulation by E2F6","",724.3,740.4,700.3,544,600.8,385.1,1.4151251715798416,0.500929668909226,0.032052883506986214,1.494132894855232,0.1874196204420498,0.7271849459793153,1250]
["Q8N4Q0","Prostaglandin reductase 3 [OS=Homo sapiens]",11,4,9,4,377,40.1,8.18,24.72,"other metabolic processes;other biological processes","other cytoplasmic organelle","other molecular function","ZADH2","ENSG00000180011","","","",734.2,710.3,675.9,654.7,688.5,809.7,0.9849040828649729,-0.021944863631046172,0.8390880535438583,0.07619246210141473,0.8907617405013886,0.05023844481038424,6885]
["Q8N554","Zinc finger protein 276 [OS=Homo sapiens]",2,1,1,1,614,67.2,8.51,1.62,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF276","ENSG00000158805","","","",68.4,71.6,73.7,85.2,80.4,81.3,0.865532604293236,-0.20833992848297112,0.006555169721913212,2.1834160593764684,0.09108694961494994,1.0405438416462347,526]
["Q8N584-1","Tetratricopeptide repeat protein 39C [OS=Homo sapiens]",2,1,1,1,583,65.8,6.99,4.74,"cell organization and biogenesis;developmental processes","","","TTC39C","ENSG00000168234","","","",52.7,43.4,54.2,59.5,54.5,193.7,0.4884627884302893,-1.03367943441718,0.3150661890536765,0.5015982001115634,0.5387970930728407,0.2685747560556411,4274]
["Q8N5G2-1","macoilin [OS=Homo sapiens]",10,7,10,7,664,76.1,9.07,24.67,"developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","cytoskeletal activity","LOC111154705; MACO1","ENSANAG00000024751; ENSCAFG00000012804; ENSCAFG00040000254; ENSCATG00000033846; ENSCCAG00000030283; ENSCPOG00000012618; ENSCSAG00000000952; ENSG00000204178; ENSMMUG00000018014; ENSMNEG00000031369; ENSPANG00000000594; ENSPPAG00000042632; ENSPPYG00000001709; ENSPTRG00000029594","","RHOC GTPase cycle; RHOA GTPase cycle","",1289.6,1153.1,1234.6,1268.5,1476.8,1496,0.8670219036616131,-0.2058596540298456,0.08603260811446652,1.0653369110810185,0.3010111693195959,0.521417389177354,2089]
["Q8N5U6-1","RING finger protein 10 [OS=Homo sapiens]",5,3,3,3,811,89.9,6.92,6.95,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RNF10","ENSG00000022840","","","",144,153.6,150.8,172.1,184.4,265.3,0.7211321968478611,-0.4716643385356373,0.12046196398864524,0.9191500604541819,0.35091928847868,0.4547927598848195,2509]
["Q8N5X7","Eukaryotic translation initiation factor 4E type 3 [OS=Homo sapiens]",15,3,5,3,224,24.4,6.42,13.8,"protein metabolism;other metabolic processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity","EIF4E3","ENSG00000163412","","ISG15 antiviral mechanism","",754.3,695.8,695.8,743.5,754,869.7,0.9065140250084487,-0.14159875428515,0.17565040926679218,0.7553508339613243,0.4177770391574956,0.3790554323337295,3073]
["Q8N6H7","ADP-ribosylation factor GTPase-activating protein 2 [OS=Homo sapiens]",28,14,36,14,521,56.7,7.99,94.25,"cell organization and biogenesis;transport","plasma membrane;other membranes;cytosol;ER/Golgi","enzyme regulator activity;other molecular function","ARFGAP2","ENSG00000149182","Endocytosis","COPI-dependent Golgi-to-ER retrograde traffic; CDC42 GTPase cycle; COPI-mediated anterograde transport","IL-18 signaling pathway",4967.8,4969.2,4859.3,6443.8,6159.8,5531.6,0.8158884379549163,-0.29355619883347606,0.014944546173139754,1.8255172688143115,0.13239962179330722,0.8781132554802636,825]
["Q8N6M3","fat storage-inducing transmembrane protein 2 [OS=Homo sapiens]",5,1,2,1,262,29.8,8.65,6.54,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","FITM2","ENSG00000197296","","Lipid particle organization","",211.9,238.4,242.9,243.9,233.8,112.4,1.1747161498051177,0.23231219616048324,0.47221655202595086,0.32585879420022,0.6355055751717317,0.1968806351088746,5431]
["Q8N806","Putative E3 ubiquitin-protein ligase UBR7 [OS=Homo sapiens]",21,6,15,6,425,48,4.81,48.09,"protein metabolism;other metabolic processes","other cell component","other molecular function","UBR7","ENSG00000012963; ENSG00000278787","","","",1173.7,1135.9,1146.2,1509,1541.6,1218.8,0.8094345809715652,-0.30501360919795795,0.05834136371122623,1.2340234235972387,0.25306648508329527,0.5967653669206231,1685]
["Q8N8Q9","Magnesium transporter NIPA2 [OS=Homo sapiens]",4,1,1,1,360,39.2,8.22,5.24,"transport","plasma membrane;other membranes;other cytoplasmic organelle","transporter activity","NIPA2","ENSG00000140157","","Miscellaneous transport and binding events","Prader-Willi and Angelman syndrome; 15q11.2 copy number variation syndrome",211.3,194.3,188,186.5,190.9,41.4,1.4173829990448903,0.5032296496899951,0.3053191222316134,0.5152459948510152,0.5324689726535105,0.27370569380088655,4191]
["Q8N8S7","Protein enabled homolog [OS=Homo sapiens]",12,6,8,6,591,66.5,6.93,18.75,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ENAH","ENSG00000154380","Rap1 signaling pathway; Axon guidance; Regulation of actin cytoskeleton","Generation of second messenger molecules; Signaling by ROBO receptors","Regulation of actin cytoskeleton",921.8,919.2,911.9,1041.3,1148.5,876.3,0.8978506898013763,-0.15545254634977826,0.2579666959247706,0.5884363588030865,0.4942276751020048,0.30607293921001283,3815]
["Q8N9B5-1","Junction-mediating and -regulatory protein [OS=Homo sapiens]",9,7,7,7,988,111.4,6.18,11.21,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","JMY","ENSG00000152409","","Regulation of TP53 Activity through Methylation","",671.8,587.2,610.1,738.6,730.5,794.9,0.8255742049469965,-0.2765302004057776,0.015280643096984327,1.8158583677764017,0.1339163314099022,0.8731664565301677,834]
["Q8N9Q2","protein SREK1IP1 [OS=Homo sapiens]",5,1,1,1,155,18.2,9.85,0,"RNA metabolism OR transcription;other metabolic processes","","nucleic acid binding activity;other molecular function","SREK1IP1","ENSG00000153006","","","",374,366.4,340.6,421.7,376.5,11.6,1.3348975055569277,0.416728974945555,0.5257512647080229,0.2792196739339762,0.6718034954110034,0.17275774084302742,5720]
["Q8N9R8-1","protein SCAI [OS=Homo sapiens]",7,4,6,4,606,70.4,8.6,11.07,"RNA metabolism OR transcription;other metabolic processes;other biological processes","other membranes;nucleus;other cell component","other molecular function","SCAI","ENSANAG00000024288; ENSCSAG00000013617; ENSG00000173611; ENSMMUG00000020633; ENSPPYG00000019606","","RHO GTPases Activate Formins","",572,597.3,570.8,569.2,571.3,1094.3,0.7786379094326114,-0.3609755082049595,0.3991495637781054,0.39886434102368334,0.5862910292713368,0.23188675082247276,4976]
["Q8NB14","Ubiquitin carboxyl-terminal hydrolase 38 [OS=Homo sapiens]",5,5,6,4,1042,116.5,6.21,13.72,"protein metabolism;other metabolic processes","cytosol;nucleus","other molecular function","USP38","ENSG00000170185","","","Integrated breast cancer pathway",307.4,334,349.1,264.9,284.5,332.3,1.1233979811727344,0.16786911540435992,0.1966553491599711,0.7062942359866887,0.43741751278461005,0.3591038332017587,3286]
["Q8NB37","Glutamine amidotransferase-like class 1 domain-containing protein 1 [OS=Homo sapiens]",23,4,9,4,220,23.3,6.61,30.33,"","","","GATD1","ENSG00000177225","","","",940.6,884.1,892.2,1166.8,993.1,1689.2,0.7058533163596684,-0.5025596872370166,0.14661504687998467,0.8338214564233452,0.38353950524187824,0.41618989631753533,2794]
["Q8NBB4","Zinc finger and SCAN domain-containing protein 1 [OS=Homo sapiens]",2,1,1,1,408,45.3,8.54,0,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZSCAN1","ENSG00000152467","","","",116.5,129.1,114.4,92.7,96.9,30.2,1.637852593266606,0.711805520267806,0.10141311195711976,0.9939058903430846,0.3252428412876649,0.4877922536394873,2279]
["Q8NBJ9-1","SID1 transmembrane family member 2 [OS=Homo sapiens]",5,2,2,2,832,94.4,6.96,5.39,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle","transporter activity;nucleic acid binding activity;other molecular function","SIDT2","ENSG00000149577","","","",28.9,32.7,30,34.4,31.3,31.4,0.9433573635427394,-0.08412369732224845,0.294087307957027,0.5315237181082627,0.5247763998676539,0.2800257041920641,4096]
["Q8NBP0-1","Tetratricopeptide repeat protein 13 [OS=Homo sapiens]",12,8,11,8,860,96.8,7.01,35.48,"","","","TTC13","ENSG00000143643","","","",819,856.3,813.6,740.2,713.4,785.3,1.1116619768636387,0.15271817435901017,0.02867772294390214,1.54245533529705,0.178996991457712,0.7471542684854401,1171]
["Q8NBS9-1","Thioredoxin domain-containing protein 5 [OS=Homo sapiens]",71,29,1001,28,432,47.6,5.97,2951.38,"transport;other biological processes","non-structural extracellular;ER/Golgi;other cytoplasmic organelle","other molecular function","TXNDC5","ENSG00000239264","Protein processing in endoplasmic reticulum","Golgi Associated Vesicle Biogenesis; Neutrophil degranulation; Lysosome Vesicle Biogenesis","VEGFA-VEGFR2 signaling pathway",109409.8,111977.4,103220.8,111578.6,111130.9,143654.6,0.8860256777342541,-0.17457958504266066,0.2772813258603375,0.5570793779839822,0.5103624302979619,0.29212130316389223,3971]
["Q8NC51-3","Isoform 3 of Plasminogen activator inhibitor 1 RNA-binding protein [OS=Homo sapiens]",46,20,124,3,393,43.1,8.44,368.7,"","","","SERBP1","","","","",16521.4,15185.9,16316,15624.2,14111.3,10340.7,1.1982997389972105,0.2609888245513467,0.178374199837123,0.7486679620600662,0.42056033116436514,0.37617169401036604,3100]
["Q8NC56-1","LEM domain-containing protein 2 [OS=Homo sapiens]",29,15,39,15,503,56.9,9,105.47,"cell organization and biogenesis;developmental processes;other biological processes","other membranes;nucleus","nucleic acid binding activity","LEMD2","ENSG00000161904","","Sealing of the nuclear envelope (NE) by ESCRT-III; Initiation of Nuclear Envelope (NE) Reformation; Depolymerisation of the Nuclear Lamina","",3314.7,3320,3376.2,2833.9,2963.2,4367.1,0.9849176521516695,-0.02192498737292809,0.9221729976386019,0.03518759860787345,0.9483836273730887,0.023015952166328034,7107]
["Q8NCG7","Sn1-specific diacylglycerol lipase beta [OS=Homo sapiens]",17,8,18,8,672,73.7,6.55,51.15,"cell-cell signaling;cell cycle OR cell proliferation;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;nucleus","other molecular function","DAGLB","ENSG00000164535","Retrograde endocannabinoid signaling; Aldosterone synthesis and secretion","Arachidonate production from DAG","Cannabinoid receptor signaling",1330,1354.4,1349.3,1325.2,1254.2,1799.3,0.9212094914015575,-0.11839881931086346,0.5386928398390902,0.2686587969415867,0.6789629188453027,0.16815394380582918,5799]
["Q8NCL4","Polypeptide N-acetylgalactosaminyltransferase 6 [OS=Homo sapiens]",4,3,4,2,622,71.1,8.18,13.51,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","GALNT6","ENSG00000139629","Mucin type O-glycan biosynthesis; Other types of O-glycan biosynthesis; Metabolic pathways","O-linked glycosylation of mucins","",162.2,185,167.6,194.7,174.3,162.2,0.9691265060240962,-0.04524309312622322,0.6650553377166654,0.17714221655388548,0.7704690859678407,0.11324478207589607,6309]
["Q8ND24","Ring finger protein 214 [OS=Homo sapiens]",8,5,7,5,703,77.6,6.95,19.94,"protein metabolism;other metabolic processes","","other molecular function","RNF214","ENSG00000167257","","","",567.8,575.5,660.5,746.3,744.3,635.3,0.8484876993273438,-0.23703434996688905,0.08523540163919127,1.0693799880591173,0.2996563494857379,0.5233765155066135,2079]
["Q8NDA8-1","Maestro heat-like repeat-containing protein family member 1 [OS=Homo sapiens]",8,15,27,15,1641,181.1,6.89,49.58,"","","","MROH1","ENSG00000179832","","","",2439.5,2431.3,2472.1,2340.3,2354.7,2622.5,1.0034711308507005,4.999111989384266E-3,0.9315468672703638,0.030795290327727896,0.9546657393268493,0.020148662947071943,7132]
["Q8NDX6","Zinc finger protein 740 [OS=Homo sapiens]",4,1,2,1,193,21.8,9.19,3.54,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF740","ENSG00000139651","","Generic Transcription Pathway","",95.9,104.3,83.2,99,93.1,330.9,0.5418738049713192,-0.8839711882162856,0.36671926884207745,0.4356662699359603,0.5666704304369438,0.2466694487897989,4730]
["Q8NE01","Metal transporter CNNM3 [OS=Homo sapiens]",13,8,8,8,707,76.1,6.09,19.59,"transport","plasma membrane;other membranes;other cell component","transporter activity","CNNM3","ENSG00000168763","","","",564.3,535.8,533.6,543.6,521.7,654.3,0.9500465224470805,-0.07392993295921228,0.5348004665724841,0.27180822252118475,0.6768582874767596,0.16950224920139367,5775]
["Q8NEL9-1","Phospholipase DDHD1 [OS=Homo sapiens]",7,5,6,5,900,100.4,5.67,14.26,"other metabolic processes;other biological processes","cytosol;other cell component","other molecular function","DDHD1","ENSG00000100523","","Synthesis of PA","",534.7,539.3,554.2,548.3,555.8,599.5,0.9557407842216483,-0.06530871101951495,0.21368500333809046,0.6702259560579837,0.4552094693669785,0.3417887122301841,3431]
["Q8NEM2","SHC SH2 domain-binding protein 1 [OS=Homo sapiens]",28,14,44,14,672,75.6,4.75,139.46,"signal transduction;other biological processes","cytoskeleton;other cell component","","SHCBP1","ENSG00000171241","","","",2742.4,2695.3,2729.7,3476.2,3515.3,3259.1,0.7967728718318927,-0.32775956688380353,1.0129591299270157E-3,2.9944080768561476,0.0393814802161519,1.4047079642358546,188]
["Q8NEZ2","Vacuolar protein sorting-associated protein 37A [OS=Homo sapiens]",7,2,2,2,397,44.3,5.57,7.15,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","","VPS37A","ENSG00000155975","Endocytosis","Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; HCMV Late Events","7q11.23 copy number variation syndrome",291,284.5,284.7,376.4,363.8,420.9,0.7408491947291362,-0.4327481935957802,0.004542124402988002,2.3427409751820383,0.07562275002605764,1.1213475335401868,439]
["Q8NF37","Lysophosphatidylcholine acyltransferase 1 [OS=Homo sapiens]",32,12,41,12,534,59.1,6.02,121.9,"other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","LPCAT1","ENSG00000153395","Glycerophospholipid metabolism; Ether lipid metabolism; Metabolic pathways","Neutrophil degranulation; Synthesis of PA; Acyl chain remodelling of PC; Acyl chain remodelling of PG; Synthesis of PC","",4146.4,4232.3,4281.3,4152.9,4147,5165.7,0.9401734790874525,-0.08900111008923627,0.47488641038543483,0.32341025825344594,0.6373383719256598,0.19562993337341875,5446]
["Q8NFG4-1","Folliculin [OS=Homo sapiens]",7,3,3,3,579,64.4,6.23,7.92,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","FLCN","ENSG00000154803","mTOR signaling pathway; Renal cell carcinoma","Amino acids regulate mTORC1","Ciliopathies",266.7,281,321.1,364.2,320.1,150.7,1.0404790419161678,0.057247905555584816,0.874766056229738,0.05810807734693707,0.9145565877532764,0.03878941759197199,6991]
["Q8NFT6-1","Protein DBF4 homolog B [OS=Homo sapiens]",1,1,1,1,615,67.2,8.34,0,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","DBF4B","ENSG00000161692","","","",654.2,660.4,613.7,610.3,596.5,1108,0.8330309313979609,-0.26355802937342443,0.48805760922739444,0.31152891182333275,0.6469374439323587,0.18913771170911467,5514]
["Q8NG11-1","Tetraspanin-14 [OS=Homo sapiens]",8,2,2,2,270,30.7,6.84,5.39,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","TSPAN14","ENSCATG00000031568; ENSCSAG00000009464; ENSG00000108219; ENSGGOG00000005770; ENSMMUG00000013895; ENSMNEG00000032257; ENSNLEG00000029109; ENSPPAG00000030989; ENSPTRG00000002686","","Neutrophil degranulation; Amyloid fiber formation","",111.2,135.5,110.5,140.5,135.4,230.6,0.7052319842053306,-0.5038301885672779,0.19478616645655863,0.7104418895770757,0.43524674125068386,0.36126447181808435,3271]
["Q8NH93","Olfactory receptor 1L3 [OS=Homo sapiens]",2,1,1,1,324,36.6,9.2,2.06,"signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","OR1L3","ENSG00000171481","Olfactory transduction","","",46.7,43.3,63.5,60.4,44.1,17.7,1.2561374795417348,0.32899437043881213,0.4952171100447923,0.3052043585968486,0.6519347725715755,0.1857958541596741,5552]
["Q8NHU6","tudor domain-containing protein 7 [OS=Homo sapiens]",4,5,5,5,1098,123.5,7.21,9.53,"developmental processes;other biological processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","TDRD7","ENSG00000196116","","","",687.7,626.9,690.9,693,675.6,463.3,1.0947649980894154,0.1306212145962325,0.49264942971790676,0.307462015605421,0.65019405594225,0.18695700513100375,5538]
["Q8NHV4","Protein NEDD1 [OS=Homo sapiens]",13,8,15,8,660,71.9,7.97,41.05,"cell cycle OR cell proliferation;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus","","NEDD1","ENSG00000139350","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",1412.4,1450.4,1387.1,1555.1,1610.2,1315,0.9485748722183781,-0.07616644300595968,0.45293812550438844,0.3439611215795856,0.6194844235238726,0.2079696091631019,5344]
["Q8NI60-1","Atypical kinase COQ8A, mitochondrial [OS=Homo sapiens]",9,6,15,6,647,71.9,6.99,44.09,"protein metabolism;other metabolic processes","other membranes;mitochondrion","kinase activity;other molecular function","COQ8A","ENSG00000163050","","","",1780.9,1871.8,1873.6,1892.7,1876.7,1911.7,0.9727517558219357,-0.03985641561489244,0.1846649976561029,0.7336154151465774,0.428073729105124,0.3684814240105091,3153]
["Q8TAF3-1","WD repeat-containing protein 48 [OS=Homo sapiens]",22,11,23,11,677,76.2,7.03,55.85,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","WDR48","ENSANAG00000001805; ENSCAFG00000005066; ENSCANG00000036746; ENSCATG00000045029; ENSCCAG00000035592; ENSCSAG00000014688; ENSFCAG00000025123; ENSG00000114742; ENSGGOG00000002185; ENSLCNG00005009903; ENSMLEG00000040913; ENSMMUG00000020138; ENSMNEG00000033674; ENSNLEG00000005481; ENSPANG00000006231; ENSPPAG00000029758; ENSPTRG00000014765; ENSRROG00000029632; ENSSSCG00070011863; ENSSTOG00000011459","Fanconi anemia pathway","Fanconi Anemia Pathway; Ub-specific processing proteases; Recognition of DNA damage by PCNA-containing replication complex; Ub-specific processing proteases; Fanconi Anemia Pathway; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins; Recognition of DNA damage by PCNA-containing replication complex","DNA repair pathways, full network",2031.2,2013.3,2072.3,2458.9,2422.6,3523.8,0.7277313123862326,-0.4585222074288697,0.1025298338511008,0.9891497463967645,0.32710194483531024,0.48531687370218896,2291]
["Q8TAQ2","SWI/SNF complex subunit SMARCC2 [OS=Homo sapiens]",38,52,186,1,1214,132.8,5.69,556.76,"cell organization and biogenesis;developmental processes;other biological processes","nucleus","other molecular function","SMARCC2","ENSG00000139613","Thermogenesis; Hepatocellular carcinoma","RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","Tumor suppressor activity of SMARCB1; Thermogenesis",22090.2,21003.6,21609.5,24004,25466.4,19261.1,0.9413922291816706,-0.08713215068464661,0.5185573719188195,0.2852031873378737,0.6678653447320972,0.17531109131906103,5675]
["Q8TB36","ganglioside-induced differentiation-associated protein 1 [OS=Homo sapiens]",10,3,4,3,358,41.3,8.34,12.93,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;mitochondrion;other cytoplasmic organelle","","GDAP1","ENSG00000104381","","Class I peroxisomal membrane protein import","Intracellular trafficking proteins involved in CMT neuropathy",135.8,130.3,124.4,126.8,114.8,241.2,0.8088235294117647,-0.30610312772567977,0.48892355878492016,0.31075903574948827,0.6472635919505492,0.18891882100565352,5521]
["Q8TBQ9","Protein kish-A [OS=Homo sapiens]",13,1,11,1,72,8.1,8.95,25.22,"transport","other membranes;ER/Golgi","","TMEM167A","ENSG00000174695","","","",1448.5,1612,1583.8,1177.1,1177.3,359.7,1.7111749751298777,0.7749872892518637,0.08099165989464997,1.0915597002351314,0.2923298973678996,0.5341267659018457,2025]
["Q8TBZ6","tRNA methyltransferase 10 homolog A [OS=Homo sapiens]",8,3,3,3,339,39.7,7.65,5.15,"RNA metabolism OR transcription;other metabolic processes","cytosol;cytoskeleton;mitochondrion;nucleus","nucleic acid binding activity;other molecular function","TRMT10A","ENSG00000145331","","tRNA modification in the nucleus and cytosol","",304.8,304.3,292.6,354.6,400.9,129.6,1.0187549429443,0.026807059239596275,0.9505718906076188,0.022015032387669893,0.9672462687527615,0.014462936936995881,7183]
["Q8TCG2","Phosphatidylinositol 4-kinase type 2-beta [OS=Homo sapiens]",11,6,9,5,481,54.7,5.97,19.27,"cell organization and biogenesis;other metabolic processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","kinase activity;other molecular function","PI4K2B","ENSG00000038210","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the ER membrane","",586.8,562.9,588.3,622.5,657.6,1155.8,0.7134939857958044,-0.487026825941946,0.2485588856384894,0.6045707068167276,0.484845715274011,0.3143964380265526,3747]
["Q8TCJ2","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [OS=Homo sapiens]",19,19,81,18,826,93.6,8.91,215.66,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi;other cell component","other molecular function","STT3B","ENSG00000163527","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum","","",11242.8,12334.7,12022.7,9802.7,10199.8,7285.3,1.3046196468751603,0.3836292600143019,0.04589975422367352,1.3381896399439621,0.22425220830269368,0.6492632715884316,1496]
["Q8TD16","Protein bicaudal D homolog 2 [OS=Homo sapiens]",42,30,63,27,824,93.5,5.44,201,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","BICD2","ENSG00000185963","","COPI-independent Golgi-to-ER retrograde traffic","",5125.5,4859.6,5007.9,6466.3,6359.7,6190,0.788441312578881,-0.34292472249992795,2.7222166922637745E-4,3.5650773073072783,0.025508566415071703,1.5933139481137857,78]
["Q8TDB6-1","E3 ubiquitin-protein ligase DTX3L [OS=Homo sapiens]",1,1,1,1,740,83.5,8.06,2.45,"protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","DTX3L","ENSG00000163840","Notch signaling pathway","Antigen processing: Ubiquitination & Proteasome degradation","Notch signaling",58.6,63,58.5,128.3,117.4,140.9,0.4658561821003621,-1.1020434563049597,5.8335876849506941E-4,3.234064269845538,0.03158347584392935,1.500540076456571,135]
["Q8TDI8","Transmembrane channel-like protein 1 [OS=Homo sapiens]",1,1,2,1,760,87.7,6.52,3.9,"transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","transporter activity","TMC1","ENSG00000165091","","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea","",358.2,391.9,465.8,314.8,302.2,73.1,{"$f":"AVERAGE(S4674:U4674)/AVERAGE(V4674:X4674)","v":1.7619185625271698},{"$f":"LOG(Y4674,2)","v":0.817147243127006},{"$f":"TTEST(V4674:X4674,S4674:U4674,2,2)","v":0.10742236184031914},0.9689053032457405,{"$f":"AA4674*7309/AE4674","v":0.33382229706245437},0.4764846587658684,2352]
["Q8TDY2-1","RB1-inducible coiled-coil protein 1 [OS=Homo sapiens]",17,26,40,26,1594,183,5.41,90.54,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RB1CC1","ENSG00000023287","Autophagy; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration","Macroautophagy","Alzheimer's disease and miRNA effects; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Malignant pleural mesothelioma; Alzheimer's disease; Senescence and autophagy in cancer",3270.4,3282.2,3460.1,3691.5,3444.4,4135.3,0.8883437433458726,-0.17081006148664604,0.11799202012273521,0.9281473633197278,0.34704373242538095,0.4596157945051058,2485]
["Q8TEA8","D-aminoacyl-tRNA deacylase 1 [OS=Homo sapiens]",35,6,23,6,209,23.4,8.24,66.76,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DTD1","ENSG00000125821","","","",2423.7,2580.5,2467.8,2712.2,2318.4,1590.5,1.12851338901391,0.17442353518848458,0.4408981319581042,0.35566174123266125,0.6111368189800461,0.21386155068015247,5273]
["Q8TED0","U3 small nucleolar RNA-associated protein 15 homolog [OS=Homo sapiens]",21,12,22,12,518,58.4,9.11,54.87,"RNA metabolism OR transcription;other metabolic processes;other biological processes","ER/Golgi;nucleus;other cell component","","UTP15","ENSG00000164338","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",2746.9,2750.9,2792.5,3149.9,3011.4,4193.2,0.8006470616640107,-0.3207616757222304,0.1390684437883053,0.8567714051867175,0.37535127608889346,0.42556210331585115,2708]
["Q8TET4","neutral alpha-glucosidase c [OS=Homo sapiens]",5,2,2,2,914,104.3,6.23,6.3,"protein metabolism;other metabolic processes","","other molecular function","GANC","ENSG00000214013","Galactose metabolism; Starch and sucrose metabolism; Metabolic pathways","","",44.1,47.8,42.8,50.7,42,50.9,0.9380222841225626,-0.09230589836074833,0.41872209720375714,0.37807411949943154,0.5968096350355423,0.2241641741262196,5128]
["Q8TEU7","Rap guanine nucleotide exchange factor 6 [OS=Homo sapiens]",12,16,23,14,1601,179.3,6.4,67.06,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","RAPGEF6","ENSG00000158987","Rap1 signaling pathway; Tight junction","","",1490.9,1436.4,1482.4,1735.6,1729.3,4314.7,0.5668286287212712,-0.8190154688276948,0.2619734553687274,0.5817427116226845,0.497729135765539,0.30300693604552703,3847]
["Q8TF30","WASP homolog-associated protein with actin, membranes and microtubules [OS=Homo sapiens]",3,2,3,2,809,90.9,7.08,12.4,"cell adhesion;cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","WHAMM","ENSG00000156232","Tight junction","RHOD GTPase cycle","",152,123.4,156.6,128,130.1,230.8,0.8836162814481489,-0.1785080929573065,0.6212400213879526,0.2067405740186976,0.7401211599551012,0.1306971791977477,6135]
["Q8WTS6","Histone-lysine N-methyltransferase SETD7 [OS=Homo sapiens]",34,10,22,10,366,40.7,4.63,70.13,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","other molecular function","SETD7","ENSG00000145391","Lysine degradation; Metabolic pathways; FoxO signaling pathway","PKMTs methylate histone lysines","Histone modifications",2230.3,2303.2,2245.3,2499.9,2585,2431.2,0.9019039129335693,-0.14895435510776228,0.007803241010968186,2.1077249792542547,0.09850412530080564,1.006545581097718,579]
["Q8WTW4","GATOR complex protein NPRL2 [OS=Homo sapiens]",10,3,4,3,380,43.6,6.52,11.64,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;other cytoplasmic organelle;other cell component","enzyme regulator activity;kinase activity","NPRL2","ENSG00000114388","mTOR signaling pathway","Amino acids regulate mTORC1","22q11.2 copy number variation syndrome",295.6,275.4,301.8,327.7,343.9,245.6,0.9515918011338859,-0.0715852532571861,0.6624947945492123,0.1788175297797348,0.768477139082716,0.11436904751088861,6301]
["Q8WUA4-1","General transcription factor 3C polypeptide 2 [OS=Homo sapiens]",14,9,12,9,911,100.6,7.31,32.67,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","GTF3C2","ENSG00000115207; ENSPPAG00000042866; ENSPTRG00000011763","","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter","",1384,1311.4,1460.1,1673.2,1636.9,2452.1,0.7211655270556384,-0.4715976597567919,0.11765352470276245,0.929395057556975,0.34674581131148824,0.4599887764992184,2480]
["Q8WUF8","Protein Fam172a [OS=Homo sapiens]",11,4,5,4,416,47.9,6.09,13.07,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","ER/Golgi;nucleus","","FAM172A","ENSG00000113391","","","",207.2,232.6,216.5,233.4,226.8,204.9,0.9867689069312884,-0.01921583782529237,0.8091172132601743,0.09198855949437255,0.8709628441411802,0.060000371890901294,6790]
["Q8WUM0","Nuclear pore complex protein Nup133 [OS=Homo sapiens]",39,35,105,35,1156,128.9,5.1,328.44,"cell organization and biogenesis;other metabolic processes;transport;developmental processes","other membranes;cytosol;nucleus;other cell component","other molecular function","NUP133","ENSG00000069248","Nucleocytoplasmic transport; Amyotrophic lateral sclerosis","Separation of Sister Chromatids; Transport of Mature mRNA derived from an Intron-Containing Transcript; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; ISG15 antiviral mechanism; Transcriptional regulation by small RNAs; tRNA processing in the nucleus; Viral Messenger RNA Synthesis; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; HCMV Early Events; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Postmitotic nuclear pore complex (NPC) reformation","Ciliary landscape",9449.9,9484.7,9860.7,8540,8584.7,5453.8,1.2753415860221005,0.3508837086199284,0.11828152050001214,0.927083101287274,0.34719663989340915,0.45942448649903733,2490]
["Q8WUX1-1","Sodium-coupled neutral amino acid transporter 5 [OS=Homo sapiens]",10,5,11,5,472,51.4,8.21,26.74,"transport","plasma membrane;other membranes","transporter activity","SLC38A5","ENSG00000017483","GABAergic synapse","Amino acid transport across the plasma membrane","Neuroinflammation and glutamatergic signaling",1602.3,1537.8,1690.7,1629.2,1621.1,1907.1,0.9366735176639392,-0.09438181810736342,0.3540081668525313,0.45098671882710323,0.5621215927710518,0.2501697318371045,4603]
["Q8WUY1","Protein THEM6 [OS=Homo sapiens]",26,5,8,5,208,23.9,9.55,20.98,"","non-structural extracellular","","THEM6","ENSG00000130193","","","",1124.9,1048.4,1123.9,875.1,1031.3,2520.2,0.7448606153707135,-0.4249576133757324,0.5128836876347979,0.2899811135348563,0.6644216364627327,0.17755623347023075,5642]
["Q8WVB3","Hexosaminidase D [OS=Homo sapiens]",14,4,7,4,486,53.8,5.97,9.2,"other metabolic processes","non-structural extracellular;nucleus;other cell component","other molecular function","HEXD","ENSG00000169660","Other glycan degradation; Various types of N-glycan biosynthesis; Metabolic pathways","","",455.6,505.8,457.8,439.9,476.2,855.8,0.8009481347705852,-0.3202192706452378,0.42983090008301356,0.36670236675717116,0.6048583074136977,0.21834635016648213,5194]
["Q8WVM0","Dimethyladenosine transferase 1, mitochondrial [OS=Homo sapiens]",10,3,5,3,346,39.5,9.26,9.47,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","nucleic acid binding activity;other molecular function","TFB1M","ENSG00000029639","","Transcriptional activation of mitochondrial biogenesis; rRNA modification in the mitochondrion","Energy metabolism; Mitochondrial gene expression",608,640.9,615.4,600.9,629.5,1067.6,0.8112706701479548,-0.3017447632670517,0.3935884665516683,0.4049576363239175,0.5831619910857782,0.23421078990208577,4933]
["Q8WVP7-1","Limb region 1 protein homolog [OS=Homo sapiens]",4,2,3,2,490,55.1,5.94,7.03,"developmental processes;signal transduction","plasma membrane;other membranes","other molecular function","LMBR1","ENSG00000105983; ENSPPYG00000018221","","","",149.9,164.4,186.2,154.2,152.3,625.6,0.5369595536959554,-0.897114673119641,0.41351135129662,0.3835125641336356,0.5942497968200935,0.2260309580893527,5086]
["Q8WW59","SPRY domain-containing protein 4 [OS=Homo sapiens]",27,4,9,4,207,23.1,6.93,24.78,"","nucleus","","SPRYD4","ENSG00000176422","","","",738.1,785.6,869.4,718.1,629.7,508.7,1.2890385133315376,0.36629536855787714,0.0674264060148955,1.1711699886178373,0.2685665403612377,0.5709480953219724,1835]
["Q8WWM7-1","ataxin-2-like protein [OS=Homo sapiens]",32,28,81,27,1075,113.3,8.59,230.61,"cell organization and biogenesis;other biological processes","other membranes;cytosol;nucleus;other cell component","","ATXN2L","ENSG00000168488","Amyotrophic lateral sclerosis; Spinocerebellar ataxia; Pathways of neurodegeneration","","16p11.2 distal deletion syndrome",9887.4,8672.5,9513.6,14436.5,13757.8,15680.9,0.6398489351615492,-0.6441967619911954,1.3982799938197252E-3,2.854405856061443,0.04443490641229727,1.3522757301950625,230]
["Q8WWW0-2","Isoform 2 of Ras association domain-containing protein 5 [OS=Homo sapiens]",20,5,16,5,265,30.3,8.09,42.51,"","","","RASSF5","","","","",1694.2,1690.6,1521,1937.3,2150.7,1407,0.8927752502274795,-0.1636310619731797,0.4382470006087079,0.3582810475639902,0.6089633702374613,0.21540882983375628,5260]
["Q8WXB1-1","Protein N-lysine methyltransferase METTL21A [OS=Homo sapiens]",4,1,1,1,218,24.6,6.27,2.67,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","METTL21A","ENSG00000144401","","Protein methylation","",84.5,72,74.6,62.5,73.6,98.9,0.983404255319149,-0.024143496984731047,0.9148853523604795,0.03863332555848385,0.9432779010301516,0.02536034002654233,7089]
["Q8WXE9-1","Stonin-2 [OS=Homo sapiens]",7,4,6,4,905,101.1,5.39,16.32,"transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","STON2","ENSG00000140022","","Cargo recognition for clathrin-mediated endocytosis","",403.2,444.1,432.8,504.1,466.4,581.2,0.8249661661403621,-0.27759314273187613,0.06531636729246702,1.1849779774673306,0.264339606057941,0.5778377615608448,1806]
["Q8WXX7-1","Autism susceptibility gene 2 protein [OS=Homo sapiens]",1,1,1,1,1259,138.9,9.38,2.35,"cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","AUTS2","ENSG00000158321","","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","",65.4,59.8,60.1,83.8,76.7,669.2,0.2233337350849705,-2.1627269047937503,0.3353980234091836,0.47443950113665334,0.5501400702643005,0.2595267214183529,4456]
["Q8WYP5","protein elys [OS=Homo sapiens]",23,37,83,37,2266,252.3,6.6,286.37,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity","AHCTF1","ENSG00000153207","Nucleocytoplasmic transport","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation","Gastric cancer network 2",6578.8,6532.3,6623.8,7453.9,7415.2,9060.2,0.8247169787666166,-0.2780289856902028,0.06155249632754364,1.2107543290967158,0.25737253756179435,0.589437795511127,1748]
["Q8WZ42","Titin [OS=Homo sapiens]",0,7,16,3,34350,3813.7,6.35,25.83,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus","cytoskeletal activity;kinase activity;other molecular function","TTN","ENSG00000155657","Hypertrophic cardiomyopathy; Dilated cardiomyopathy","Platelet degranulation ; Striated Muscle Contraction","Striated muscle contraction pathway",1642.2,1519,1593.8,1534.8,1489.4,794.2,1.2452859836580767,0.3164770995830843,0.2670921587942703,0.5733388616692546,0.503397779429428,0.2980887045279682,3878]
["Q92187-1","CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase [OS=Homo sapiens]",7,2,2,2,359,41.3,9.74,6.59,"protein metabolism;other metabolic processes;developmental processes","other membranes;ER/Golgi","other molecular function","ST8SIA4","ENSANAG00000034757; ENSCCAG00000025138; ENSG00000113532; ENSGGOG00000011260; ENSNLEG00000035472; ENSPPAG00000033695; ENSPPYG00000015661; ENSPTRG00000042921","","Sialic acid metabolism; NCAM1 interactions","Ectoderm differentiation",60.5,67.5,60.9,91.3,96.3,431.4,0.30516962843295636,-1.7123167077132573,0.27177104125431123,0.5657968216781637,0.5072457968661289,0.294781542925291,3916]
["Q92508","Piezo-type mechanosensitive ion channel component 1 [OS=Homo sapiens]",11,19,33,19,2521,286.6,7.47,120.25,"transport;other biological processes","plasma membrane;other membranes;ER/Golgi","transporter activity","PIEZO1","ENSG00000103335","","","",2124.5,2203.9,2201.7,1730.6,1839.7,2975.8,0.9975557965811704,-3.5305566103564553E-3,0.9899749608441575,0.00437578975066615,0.9926913141459661,3.1857780952811105E-3,7289]
["Q92522","Histone H1x [OS=Homo sapiens]",54,15,108,15,213,22.5,10.76,339.77,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity","H1-10","ENSG00000184897","","","",18093.2,18656.4,17707.5,11792.9,12834.8,16936.8,1.310182968639103,0.38976829994264334,0.05432010610216611,1.2650393904296855,0.24387325276457747,0.6128358290988949,1628]
["Q92544","Transmembrane 9 superfamily member 4 [OS=Homo sapiens]",20,12,30,12,642,74.5,6.54,95.66,"cell adhesion;cell organization and biogenesis;stress response;transport;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","","TM9SF4","ENSG00000101337","","","",2828.1,2928.4,2962.7,2820.1,2629.9,2889.2,1.0455679201841903,0.06428678256850658,0.22091172523243174,0.6557812326636332,0.462648653216001,0.3347486977388402,3490]
["Q92551","Inositol hexakisphosphate kinase 1 [OS=Homo sapiens]",7,2,2,2,441,50.2,7.24,4.45,"other metabolic processes;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","IP6K1","ENSG00000176095","Phosphatidylinositol signaling system","Synthesis of pyrophosphates in the cytosol; Synthesis of IPs in the nucleus","",233.4,275.7,237.9,253.9,290.2,124.1,1.1179287638431608,0.16082826034162925,0.6410963609011757,0.19307668832454153,0.7541885243564612,0.12252008005368357,6213]
["Q92576-1","PHD finger protein 3 [OS=Homo sapiens]",11,13,21,13,2039,229.3,6.96,77.84,"RNA metabolism OR transcription;other metabolic processes;developmental processes","","other molecular function","PHF3","ENSG00000118482","","","",1321.8,1291,1367.5,2066.4,2126.5,3624.3,0.5091720820754234,-0.9737747765033832,0.06623614573689919,1.1789049469643749,0.26614622825233436,0.5748796841438856,1819]
["Q92609-1","TBC1 domain family member 5 [OS=Homo sapiens]",28,15,26,15,795,88.9,6.54,79.85,"other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","TBC1D5","ENSG00000131374","","","",889,864.7,882.1,890.1,890.9,900.7,0.9828839914979305,-0.02490694766756625,0.12811769772784695,0.8923908742001891,0.3619684007316712,0.4413293410327596,2587]
["Q92613","protein jade-3 [OS=Homo sapiens]",5,4,4,4,823,93.7,7.18,7.19,"protein metabolism;other metabolic processes","nucleus","other molecular function","JADE3","ENSG00000102221","","HATs acetylate histones","",175.8,205.1,200.6,216.1,211.7,575.8,0.5794141092068554,-0.7873332790485916,0.3094926832285643,0.5093496137554014,0.5355307816566233,0.2712155613971843,4224]
["Q92622-1","Run domain Beclin-1-interacting and cysteine-rich domain-containing protein [OS=Homo sapiens]",7,5,8,5,972,108.6,6.25,16.64,"other metabolic processes;transport;other biological processes","cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RUBCN","ENSG00000145016","Autophagy","","",690.1,689.5,700,813,733.9,1170,0.7654311899591445,-0.3856554054270933,0.18855698207207996,0.7245573814803984,0.43108006942909993,0.36544205586811335,3197]
["Q92696","geranylgeranyl transferase type-2 subunit alpha [OS=Homo sapiens]",30,14,42,14,567,65,5.67,113.42,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","RABGGTA","ENSG00000100949; ENSG00000285193","","RAB geranylgeranylation; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain","",4202,4111.3,4331.7,4336.4,4057.9,6456.2,0.8514864819366351,-0.2319444687977395,0.3881550071976997,0.4109948070677302,0.580287369115972,0.2363568824475928,4889]
["Q92747","Actin-related protein 2/3 complex subunit 1A [OS=Homo sapiens]",19,6,19,5,370,41.5,8.18,61.41,"cell organization and biogenesis","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity","ARPC1A","ENSG00000241685","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection","Clathrin-mediated endocytosis; FCGR3A-mediated phagocytosis; EPHB-mediated forward signaling; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs","Pathogenic Escherichia coli infection",2439.5,2487.5,2334,2208.8,2134.5,2058.3,1.1342476880779806,0.18173571906548647,0.010322645665529512,1.986208979967979,0.11030441106630878,0.9574071198041221,684]
["Q92793-1","CREB-binding protein [OS=Homo sapiens]",8,15,27,8,2442,265.2,8.53,70.88,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CREBBP","ENSG00000005339","cAMP signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Cell cycle; Wnt signaling pathway; Notch signaling pathway; TGF-beta signaling pathway; Adherens junction; JAK-STAT signaling pathway; Long-term potentiation; Melanogenesis; Thyroid hormone signaling pathway; Glucagon signaling pathway; Growth hormone synthesis, secretion and action; Huntington disease; Tuberculosis; Hepatitis B; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Pathways in cancer; Viral carcinogenesis; MicroRNAs in cancer; Renal cell carcinoma; Prostate cancer","Heme signaling; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RORA activates gene expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; HATs acetylate histones; SUMOylation of transcription cofactors; Pre-NOTCH Transcription and Translation; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production; Formation of the beta-catenin:TCF transactivating complex; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation; Attenuation phase; CD209 (DC-SIGN) signaling; Activation of the TFAP2 (AP-2) family of transcription factors; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Regulation of gene expression by Hypoxia-inducible Factor; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells","Androgen receptor signaling pathway; Angiogenesis; TNF-alpha signaling pathway; Notch signaling; Initiation of transcription and translation elongation at the HIV-1 LTR; IL-6 signaling pathway; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Wnt signaling pathway and pluripotency; Clear cell renal cell carcinoma pathways; Ebola virus pathway in host; Type 2 papillary renal cell carcinoma; Ciliary landscape; Hepatitis B infection; Male infertility; TGF-beta receptor signaling in skeletal dysplasias; Overlap between signal transduction pathways contributing to LMNA laminopathies; 15q13.3 copy number variation syndrome; TGF-beta receptor signaling; Sudden infant death syndrome (SIDS) susceptibility pathways",1980.7,1878.3,2006.1,2357.5,2433.6,1857.4,0.8821689102805146,-0.1808731775477755,0.23071529195678,0.6369236192095078,0.46998273938464463,0.3279180916975893,3588]
["Q92797-1","Symplekin [OS=Homo sapiens]",28,34,94,34,1274,141.1,6.13,244.46,"cell adhesion;RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","","SYMPK","ENSG00000125755","mRNA surveillance pathway; Tight junction","mRNA Splicing - Major Pathway; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs","",11017.3,11020.3,11757.6,12437.5,12592.7,13783.1,0.8707118436206144,-0.19973274754674983,0.02714807447932453,1.5662609680147064,0.17451651395724097,0.7581634708184682,1137]
["Q92845","Kinesin-associated protein 3 [OS=Homo sapiens]",10,7,10,6,792,91.1,5.08,27.94,"cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","KIFAP3","ENSG00000075945","","COPI-dependent Golgi-to-ER retrograde traffic; Translocation of SLC2A4 (GLUT4) to the plasma membrane; MHC class II antigen presentation; Kinesins; Intraflagellar transport","Genes related to primary cilium development (based on CRISPR)",336.1,323.1,330,388.8,370.6,430.5,0.8313303638961257,-0.266506188721157,0.020992089912550905,1.6779443221462265,0.15404737466951263,0.8123456986859523,996]
["Q92882","osteoclast-stimulating factor 1 [OS=Homo sapiens]",37,5,15,5,214,23.8,5.68,53.68,"signal transduction;other biological processes","other cell component","other molecular function","OSTF1","ENSG00000134996","","Neutrophil degranulation","",1226.9,1173.3,1135.6,1365.7,1370.2,1973.4,0.7508122226233198,-0.4134759586044041,0.12702178011067178,0.8961218052575902,0.360824792393665,0.44270362958396386,2573]
["Q92890-1","Isoform Long of Ubiquitin recognition factor in ER-associated degradation protein 1 [OS=Homo sapiens]",37,13,34,13,343,38.7,6.34,102.54,"","","","UFD1","","","","",4522.8,4509.4,4467.4,4680.2,4671.1,5170.7,0.9295964743148326,-0.10532349785119473,0.10913040161394202,0.9620542465342978,0.33598740749633627,0.4736769992688973,2374]
["Q92918","mitogen-activated protein kinase kinase kinase kinase 1 [OS=Homo sapiens]",23,14,25,14,833,91.2,8.34,62.26,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes","","kinase activity;other molecular function","MAP4K1","ENSG00000104814; ENSG00000282928","MAPK signaling pathway","","B cell receptor signaling pathway; Cardiac hypertrophic response; Hepatocyte growth factor receptor signaling; TGF-beta signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; EGF/EGFR signaling pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Insulin signaling; Modulators of TCR signaling and T cell activation; Malignant pleural mesothelioma; T-cell receptor (TCR) signaling pathway",1701.7,1654.2,1720,1601.1,1634,2020.1,0.9658814126959963,-0.0500820236498916,0.6828983997043392,0.16564390500071813,0.7835642705555753,0.10592537545209563,6370]
["Q92963","GTP-binding protein Rit1 [OS=Homo sapiens]",17,2,3,2,219,25.1,9.1,10.42,"signal transduction","plasma membrane;other membranes","other molecular function","RIT1","ENSG00000143622","","Signalling to p38 via RIT and RIN","Ectoderm differentiation; Ectoderm differentiation",90.8,112.3,121.1,111.9,101.5,135.3,0.9297390306854028,-0.10510227325916323,0.576489213925172,0.2392088139141229,0.7074478953289259,0.15030554111028843,5956]
["Q92966","snRNA-activating protein complex subunit 3 [OS=Homo sapiens]",11,2,2,2,411,46.7,5.27,3.54,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SNAPC3","ENSG00000164975","","RNA polymerase II transcribes snRNA genes; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter","",15.8,14.9,16.5,15.9,16.3,317.4,0.1350114416475973,-2.8888464201387567,0.37234127360651537,0.42905882006405793,0.5702938744321083,0.24390129317838918,4772]
["Q92997","segment polarity protein dishevelled homolog DVL-3 [OS=Homo sapiens]",11,6,9,4,716,78,6.65,16.05,"cell-cell signaling;developmental processes;signal transduction;other biological processes","cytosol;other cell component","signal transduction activity or receptor binding;other molecular function","DVL3","ENSG00000161202","mTOR signaling pathway; Wnt signaling pathway; Notch signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer","WNT mediated activation of DVL; Degradation of DVL; RHO GTPases Activate Formins; PCP/CE pathway; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Negative regulation of TCF-dependent signaling by DVL-interacting proteins; WNT5:FZD7-mediated leishmania damping","Alzheimer's disease and miRNA effects; Neural crest differentiation; Notch signaling; Wnt signaling pathway; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Ciliary landscape; Joubert syndrome; Malignant pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)",730.9,729.2,746.6,795.1,785.1,2214,0.5815982288756523,-0.7819052190208522,0.32739565796738807,0.4849270846470709,0.5458336825008301,0.26293966823941073,4384]
["Q93034","Cullin-5 [OS=Homo sapiens]",22,18,47,18,780,90.9,7.94,120.07,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;transport;signal transduction","cytosol;other cell component","transporter activity;other molecular function","CUL5","ENSG00000166266","Ubiquitin mediated proteolysis; Human immunodeficiency virus 1 infection","Antigen processing: Ubiquitination & Proteasome degradation; Vif-mediated degradation of APOBEC3G; Neddylation; Inactivation of CSF3 (G-CSF) signaling; Downregulation of ERBB2 signaling","Apoptosis-related network due to altered Notch3 in ovarian cancer; Dual hijack model of Vif in HIV infection; Modulators of TCR signaling and T cell activation",4768.5,4715.1,4727.9,4815.3,4629,3492.8,1.0985073934653056,0.13554457980200504,0.3624430363964678,0.4407602399140651,0.5650802374193223,0.24788988104012638,4688]
["Q93086-1","Isoform 2 of P2X purinoceptor 5 [OS=Homo sapiens]",6,2,2,2,421,47.1,7.28,7.62,"","","","P2RX5","","","","",314.1,308.7,383.8,349.1,274.4,254.6,1.146338685798884,0.19703335136699524,0.31806659693013545,0.49748193771639676,0.5402623186061725,0.2673953219149793,4303]
["Q969F2-1","protein naked cuticle homolog 2 [OS=Homo sapiens]",3,1,1,1,451,50,7.96,4.31,"cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","NKD2","ENSG00000145506; ENSG00000276920","Wnt signaling pathway; Hippo signaling pathway","","Wnt signaling pathway and pluripotency; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma",30.7,23.1,24.2,20.4,21.2,81,0.6362153344208809,-0.652412949941171,0.5027254610477789,0.2986691189244261,0.6563809208285488,0.1828440511705967,5598]
["Q969H4","Connector enhancer of kinase suppressor of Ras 1 [OS=Homo sapiens]",8,3,3,3,720,79.7,5.38,10.8,"signal transduction","plasma membrane;other membranes;other cell component","other molecular function","CNKSR1","ENSG00000142675","","Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants","",75,58.8,61.7,82.3,79.1,88.5,0.7823129251700681,-0.354182293891989,0.03349048029012104,1.4750786241575475,0.19108658894652203,0.718769792018261,1281]
["Q969M1","Mitochondrial import receptor subunit TOM40B [OS=Homo sapiens]",5,2,6,2,308,33.9,7.24,24.12,"cell organization and biogenesis;transport","other membranes;mitochondrion;other cell component","transporter activity;other molecular function","TOMM40L","ENSG00000158882","Amyotrophic lateral sclerosis; Pathways of neurodegeneration","","",369.7,407.8,401,336.9,377.6,679.3,0.8455302051944326,-0.24207180139243387,0.5449312227766714,0.26365830772969134,0.6834080829229052,0.16531988894367086,5828]
["Q969R5-1","Lethal(3)malignant brain tumor-like protein 2 [OS=Homo sapiens]",2,1,1,1,705,79.1,6.84,4.57,"cell organization and biogenesis;other biological processes","nucleus","other molecular function","L3MBTL2","ENSG00000100395","","SUMOylation of chromatin organization proteins; Transcriptional Regulation by E2F6","",86,85.1,86.7,135.2,130.1,288.8,0.4652589785237323,-1.103894103341943,0.1307355041005611,0.883606454186457,0.3656891693344818,0.4368879020298097,2613]
["Q969S9","Ribosome-releasing factor 2, mitochondrial [OS=Homo sapiens]",15,12,19,11,779,86.5,6.51,52.92,"cell organization and biogenesis;protein metabolism;other metabolic processes","mitochondrion","other molecular function","GFM2","ENSG00000164347","","Mitochondrial translation termination","",2875.6,3007.8,2885.6,2776.4,2718.5,2843.1,1.051691053010314,0.07271095771881972,0.06136017892928903,1.2121133826332349,0.25759997001388485,0.5890541918665931,1741]
["Q969V6","MKL/myocardin-like protein 1 [OS=Homo sapiens]",2,2,3,1,931,98.9,5.86,5.08,"cell organization and biogenesis;stress response;other biological processes","cytosol;nucleus;other cell component","cytoskeletal activity;other molecular function","MRTFA","ENSG00000196588","","RHO GTPases Activate Formins; SUMOylation of transcription cofactors","",45.5,37.3,43.8,47.7,47.3,138.9,0.5412569474134244,-0.8856144569240866,0.3069478011589238,0.5129354733700705,0.5346714677479918,0.27191299100761784,4196]
["Q969X6","U3 small nucleolar RNA-associated protein 4 homolog [OS=Homo sapiens]",8,6,11,6,686,76.8,8.85,25.28,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","UTP4","ENSG00000141076; ENSG00000262788","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",1106.4,1102.7,1127.2,1154.1,1180.9,1315.6,{"$f":"AVERAGE(S4994:U4994)/AVERAGE(V4994:X4994)","v":0.9139045636333756},{"$f":"LOG(Y4994,2)","v":-0.12988457813973844},{"$f":"TTEST(V4994:X4994,S4994:U4994,2,2)","v":0.10691095455828763},0.9709777928223683,{"$f":"AA4994*7309/AE4994","v":0.33336696538674243},0.4770774382844484,2344]
["Q96A26","Protein FAM162A [OS=Homo sapiens]",12,2,6,2,154,17.3,9.77,21.68,"stress response;other biological processes","other membranes;cytosol;mitochondrion","","FAM162A","ENSG00000114023","","","",450.6,505,407.3,637.5,644.6,379.6,0.8201841487633147,-0.28598023310657816,0.3382158836274034,0.4708060004941848,0.5519133497282187,0.25812910105489967,4479]
["Q96AA3","Protein RFT1 homolog [OS=Homo sapiens]",5,3,6,3,541,60.3,8.85,12.36,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport","other membranes;ER/Golgi","transporter activity","RFT1","ENSG00000163933","","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective RFT1 causes CDG-1n","",588,629.9,608.6,544.3,554.9,433.3,1.1918433931484504,0.25319467978387467,0.07384385353446708,1.1316856477745794,0.27863950721911196,0.5549573066097172,1937]
["Q96AC1","Fermitin family homolog 2 [OS=Homo sapiens]",3,2,2,2,680,77.8,6.7,1.98,"cell adhesion;cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","FERMT2","ENSG00000073712","","RAC1 GTPase cycle; RAC3 GTPase cycle; Cell-extracellular matrix interactions","",116.3,105.6,104.9,106.7,88.4,124,1.0241303666562205,0.03439937486637122,0.8257196320661985,0.08316738962394923,0.8814349044503935,0.05480975560729506,6847]
["Q96AJ9-1","Isoform 1 of Vesicle transport through interaction with t-SNAREs homolog 1A [OS=Homo sapiens]",34,7,13,6,203,23.4,6.15,32.44,"","","","VTI1A","","","","",1571,1606.9,1595.7,1518.5,1449.6,1486.4,1.071635424851274,0.09981417798061769,0.00919798518000122,2.036307294506369,0.10688088025537187,0.9710999780676648,629]
["Q96AY2","crossover junction endonuclease EME1 [OS=Homo sapiens]",4,1,1,1,570,63.2,7.05,0,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","EME1","ENSG00000154920","Homologous recombination; Fanconi anemia pathway","Fanconi Anemia Pathway; Resolution of D-loop Structures through Holliday Junction Intermediates","",12.9,13.3,16.9,17.9,18.2,4.9,1.0512195121951222,0.07206395958365247,0.8855535216101419,0.05278518553261737,0.921222699893044,0.03563536910465119,7026]
["Q96AZ6-1","Interferon-stimulated gene 20 kDa protein [OS=Homo sapiens]",38,6,28,6,181,20.4,8.92,94.24,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ISG20","ENSG00000172183; ENSGGOG00000010365; ENSPTRG00000044668","","Interferon alpha/beta signaling","",2263,2190.7,2240.4,3119.9,2690.3,2242.1,0.8313276951926778,-0.2665108200104457,0.14964954616589474,0.8249245958832384,0.3870447745670646,0.41223879151180526,2826]
["Q96BD0","solute carrier organic anion transporter family member 4A1 [OS=Homo sapiens]",7,5,8,5,722,77.1,7.83,22.06,"transport","plasma membrane;other membranes","transporter activity","SLCO4A1","ENSG00000101187","","Transport of organic anions","",894.4,912.4,892.3,873.2,829.8,1424.6,0.862993989001151,-0.21257758422986645,0.4972999965482619,0.30338154378219456,0.6536172765278271,0.1846764769751219,5561]
["Q96BI3-1","gamma-secretase subunit APH-1A [OS=Homo sapiens]",5,2,3,2,265,29,7.9,9.98,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle","enzyme regulator activity;other molecular function","APH1A","ENSANAG00000030676; ENSCANG00000034955; ENSCATG00000033983; ENSCCAG00000036376; ENSCSAG00000018098; ENSG00000117362; ENSGGOG00000017118; ENSMLEG00000037901; ENSMNEG00000034177; ENSNLEG00000009799; ENSPANG00000008739; ENSPPAG00000033416; ENSPPYG00000000905; ENSPTRG00000001250; ENSRBIG00000035934; ENSRROG00000045010; ENSSBOG00000025150","Notch signaling pathway; Alzheimer disease","Amyloid fiber formation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; EPH-ephrin mediated repulsion of cells; NOTCH2 Activation and Transmission of Signal to the Nucleus; Activated NOTCH1 Transmits Signal to the Nucleus; Nuclear signaling by ERBB4; NOTCH4 Activation and Transmission of Signal to the Nucleus; NRIF signals cell death from the nucleus; Regulated proteolysis of p75NTR; Noncanonical activation of NOTCH3","Alzheimer's disease and miRNA effects; Notch signaling; Alzheimer's disease; Notch signaling pathway (Netpath); Notch signaling pathway; Delta-Notch signaling pathway",466.8,480.3,437.7,556.3,523,475.5,0.8906611782865963,-0.16705138297255862,0.10018551793123134,0.9991950522922375,0.3237205793808001,0.4898296909977011,2262]
["Q96BR5","Cytochrome c oxidase assembly factor 7 [OS=Homo sapiens]",39,8,16,8,231,25.7,6.02,41.77,"","mitochondrion;nucleus","","COA7","ENSG00000162377","Thermogenesis","","",1847.9,1855.6,1776.8,2468.3,2416.3,1953.5,0.8014360714233485,-0.3193406501393117,0.052218012410403004,1.2821796628773439,0.2397370934093188,0.6202647643950212,1592]
["Q96BY9","Store-operated calcium entry-associated regulatory factor [OS=Homo sapiens]",5,1,1,1,339,37,7.58,2.79,"transport;other biological processes","other membranes;ER/Golgi;other cell component","","SARAF","ENSG00000133872","","","",83.3,83.9,71.6,96.1,99.2,189.2,0.6210663198959688,-0.6871807615843838,0.18986306408659892,{"$f":"-LOG10(AA5059)","v":0.7215595145867593},0.4315015968311416,{"$f":"-LOG10(AC5059)","v":0.36501759277920004},3216]
["Q96C01","Protein FAM136A [OS=Homo sapiens]",54,7,9,7,138,15.6,7.61,27.53,"","other cell component","","FAM136A","ENSG00000035141","","","",730.2,676.7,696.6,1009.1,1089.2,838.8,0.7161826291239657,-0.4816005681035851,0.021164337899601107,1.674395313348602,0.15392054299321842,0.8127034132211368,1005]
["Q96C92-4","Isoform 4 of Serologically defined colon cancer antigen 3 [OS=Homo sapiens]",6,1,1,1,362,40,4.88,2.97,"","","","ENTR1","","","","",13.4,20.8,22,18.1,23.8,34.3,0.7375328083989501,-0.43922086727239606,0.288642401866547,0.5396398702487135,0.5207818600944438,0.28334415154832887,4051]
["Q96CM4","Nucleoredoxin-like protein 1 [OS=Homo sapiens]",4,1,3,1,212,23.9,4.84,6.94,"other biological processes","other cell component","","NXNL1","ENSG00000171773","","","",605.6,689.6,725.9,582,612.8,584.8,1.135704652730951,0.18358770153265022,0.09494164920583487,1.0225432285395806,0.31614055309587563,0.5001197912337477,2195]
["Q96CM8","Acyl-CoA synthetase family member 2, mitochondrial [OS=Homo sapiens]",19,10,15,10,615,68.1,7.55,41.94,"other metabolic processes","mitochondrion","other molecular function","ACSF2","ENSG00000167107","","Mitochondrial Fatty Acid Beta-Oxidation","Mitochondrial long chain fatty acid beta-oxidation",1083.4,1220.8,1113.7,1234.5,1116.5,1513.5,0.8844352438866605,-0.1771715785896145,0.2990666900464423,0.5242319558574154,0.528628400858391,0.27684950786200796,4135]
["Q96CV9-2","Isoform 2 of Optineurin [OS=Homo sapiens]",41,23,58,1,571,65.2,5.17,167.77,"","","","","","","","",111,113.7,90.3,94.5,91.1,97.3,1.1134676564156947,0.15505965187838852,0.23220417042806982,0.6341299845215056,0.47091572743028925,0.32705680494455797,3604]
["Q96CW6","Probable RNA polymerase II nuclear localization protein SLC7A6OS [OS=Homo sapiens]",42,7,11,7,309,35,4.6,35.29,"transport;developmental processes;other biological processes","nucleus;other cell component","","SLC7A6OS","ENSG00000103061","","","",404.3,404.6,404.4,445.7,471.8,540.2,0.8323386156273582,-0.26475752360976185,0.044503433470384116,1.351606481609653,0.22067543774425882,0.6562460032487126,1474]
["Q96D71","RalBP1-associated Eps domain-containing protein 1 [OS=Homo sapiens]",19,9,15,9,796,86.6,5.69,50,"transport","plasma membrane;other membranes;cytosol","other molecular function","REPS1","ENSG00000135597","","Cargo recognition for clathrin-mediated endocytosis","",1057.3,1136.7,1142.3,1216.3,1242,1006.1,0.9630239002424664,-0.05435649169566972,0.6201083779169891,0.20753240111791074,0.7399791239502487,0.1307805322705079,6125]
["Q96DI7","U5 small nuclear ribonucleoprotein 40 kDa protein [OS=Homo sapiens]",35,10,29,10,357,39.3,8.1,88.99,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","","SNRNP40","ENSG00000060688","Spliceosome","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","mRNA processing",3397.5,3526.1,3644.6,3716.6,3518.5,2539.9,1.081145780051151,0.11256106699195596,0.5150676006037511,0.2881357677694894,0.6655992031140058,0.17678720667435946,5656]
["Q96DP5","Methionyl-tRNA formyltransferase, mitochondrial [OS=Homo sapiens]",7,3,7,3,389,43.8,9.66,12.69,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion","other molecular function","MTFMT","ENSG00000103707","One carbon pool by folate; Aminoacyl-tRNA biosynthesis; Metabolic pathways","Mitochondrial translation initiation","One-carbon metabolism",254,269.5,278.2,249.7,254.4,202.6,1.134427621338616,0.18196456523159626,0.15316895824444246,0.8148292414210054,0.39116419140762754,0.40764090896078997,2862]
["Q96E11","Ribosome-recycling factor, mitochondrial [OS=Homo sapiens]",27,5,18,5,262,29.3,9.79,55.07,"cell organization and biogenesis;protein metabolism;other metabolic processes","mitochondrion","translation activity","MRRF","ENSG00000148187","","Mitochondrial translation termination","",1638.8,1567.8,1563.7,1519,1811.9,1246.7,1.0420962950017476,0.05948859614101691,0.716906088743518,0.14453773109885387,0.8089959244443992,0.09205366626877412,6477]
["Q96ED9-2","Isoform 2 of Protein Hook homolog 2 [OS=Homo sapiens]",16,10,11,10,717,83,5.47,26.51,"","","","HOOK2","","","","",714.5,705,733,917.4,973.5,1729,0.5946296859029254,-0.7499366056817212,0.13510476457950388,0.8693293349594635,0.3706759475644121,0.43100559357375406,2664]
["Q96EE3","nucleoporin Seh1 [OS=Homo sapiens]",29,9,23,9,360,39.6,8.09,84.51,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","SEH1L","ENSG00000085415","Nucleocytoplasmic transport; mTOR signaling pathway; Amyotrophic lateral sclerosis","Amino acids regulate mTORC1","",2514,2865.5,2842.4,3056.7,2473.5,1927.1,1.1025304064473738,0.14081844410563416,0.5014527885732128,0.2997699492383962,0.6557735608662753,0.18324609697032837,5589]
["Q96EP0-1","E3 ubiquitin-protein ligase RNF31 [OS=Homo sapiens]",11,9,15,9,1072,119.6,6.57,36.21,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","RNF31","ENSG00000092098; ENSG00000285152","Necroptosis; NOD-like receptor signaling pathway; Shigellosis","Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway","Regulation of toll-like receptor signaling pathway",1002.1,1031.4,1014.9,1041.2,1028.9,1726.4,0.8029500856051625,-0.3166177877028045,0.34042844192133026,0.4679741628839301,0.5531772970215658,0.2571356520995705,4498]
["Q96ES6","Major facilitator superfamily domain-containing protein 3 [OS=Homo sapiens]",2,1,1,1,412,42.7,9.17,2.16,"transport","other membranes","transporter activity","MFSD3","ENSG00000167700","","","",45.5,56.7,51.8,40.9,54.3,90.4,0.8297413793103449,-0.26926635954530836,0.5247234645818643,0.28006951458845314,0.6711942251713067,0.17315178875120432,5714]
["Q96EX1","small integral membrane protein 12 [OS=Homo sapiens]",12,1,2,1,92,10.8,8.44,6.31,"","other membranes","","SMIM12","ENSG00000163866","","","",115.1,112.3,94.9,121,119.9,143.6,0.8382314694408323,-0.2545794097896437,0.10628937422676428,0.9735101498261067,0.3324214960305606,0.47831090033436063,2337]
["Q96F10","Diamine acetyltransferase 2 [OS=Homo sapiens]",13,3,6,3,170,19.1,6.04,4.77,"other metabolic processes","other cell component","other molecular function","SAT2","ENSG00000141504","Arginine and proline metabolism; Metabolic pathways; Ferroptosis","","Ferroptosis",647.8,637.9,623.5,648.7,568.8,674.9,1.008877615726062,0.01275117554053718,0.8722606886151254,0.059353700036198186,0.9135052834342959,0.03928893647813779,6979]
["Q96FF9","Sororin [OS=Homo sapiens]",6,1,1,1,252,27.6,9.61,2.45,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","CDCA5","ENSG00000146670","MicroRNAs in cancer","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion","",82.4,62.7,74.9,55,48.7,42.3,1.5068493150684934,0.5915351546446427,0.022330147110244246,1.6511084158019675,0.15738770031704455,0.8030292103070354,1037]
["Q96FL9","Polypeptide N-acetylgalactosaminyltransferase 14 [OS=Homo sapiens]",3,1,1,1,552,64.3,7.72,3.54,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","GALNT14","ENSG00000158089","Mucin type O-glycan biosynthesis; Other types of O-glycan biosynthesis; Metabolic pathways","O-linked glycosylation of mucins","",58.9,63.8,51.4,49.5,59,67.5,0.9892045454545455,-0.015659225873558436,0.9250793323204711,0.03382102173485788,0.9501693142116813,0.022198999262772322,7116]
["Q96G01","Protein bicaudal D homolog 1 [OS=Homo sapiens]",11,9,13,6,975,110.7,5.81,36.9,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","BICD1","ENSG00000151746","","COPI-independent Golgi-to-ER retrograde traffic","",512.3,496.1,520.3,632.6,634,860.6,0.7186442271530651,-0.4766503697741704,0.058706770973471885,1.2313118063020978,0.25389810002668994,0.5953405490317984,1690]
["Q96G03","Phosphoglucomutase-2 [OS=Homo sapiens]",35,23,61,22,612,68.2,6.73,151.91,"other metabolic processes","non-structural extracellular;cytosol;other cell component","other molecular function","PGM2","ENSG00000169299","Glycolysis / Gluconeogenesis; Pentose phosphate pathway; Galactose metabolism; Purine metabolism; Starch and sucrose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars","Neutrophil degranulation; Glycogen breakdown (glycogenolysis); Glycogen synthesis; Pentose phosphate pathway; Galactose catabolism","Clear cell renal cell carcinoma pathways; Glucuronidation",7146.2,7119.8,7412.2,6750.5,6653,5366.7,1.1549264259304641,0.20780094832865437,0.10046762043904674,0.9979738838201918,0.3243453347124526,0.48899234445245265,2264]
["Q96GA7","serine dehydratase-like [OS=Homo sapiens]",20,4,11,4,329,34.7,6.89,56.45,"other metabolic processes","cytosol","other molecular function","SDSL","ENSG00000139410","Glycine, serine and threonine metabolism; Cysteine and methionine metabolism; Valine, leucine and isoleucine biosynthesis; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids","Threonine catabolism","Clear cell renal cell carcinoma pathways",662.4,731.9,680.3,660.8,862.7,1307.7,0.7327634925120091,-0.44858046711283645,0.25973856551969543,0.585463562311712,0.4961916297395332,0.3043505661190161,3826]
["Q96GD0","Pyridoxal phosphate phosphatase [OS=Homo sapiens]",36,8,19,8,296,31.7,6.55,69.41,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","PDXP","ENSG00000241360","Vitamin B6 metabolism; Metabolic pathways; Biosynthesis of cofactors","","",1691.7,1836.7,1809.6,1737.1,1658.7,1715.5,1.0443527087042435,0.0626090348597182,0.20725917073985034,0.6834862438242713,0.44844798073936243,0.34828792717528817,3378]
["Q96GM1-2","Isoform 2 of Phospholipid phosphatase-related protein type 2 [OS=Homo sapiens]",2,1,2,1,427,45.5,9.52,0,"","","","PLPPR2","","","","",80.1,71.1,85.2,91.4,97,71.1,0.9109826589595376,-0.13450450306771072,0.43490272568927396,0.3616078704489396,0.6078990288894441,0.21616855039462224,5229]
["Q96GY0","Zinc finger C2HC domain-containing protein 1A [OS=Homo sapiens]",7,2,3,2,325,35.1,9.82,8.43,"","","other molecular function","ZC2HC1A","ENSG00000104427","","","",58.7,52.5,63.8,76,75.8,75.4,0.7702464788732395,-0.3766079127849908,0.006013848097843667,2.2208475458233696,0.0868680153105521,1.0611401007791956,506]
["Q96HA7","Tonsoku-like protein [OS=Homo sapiens]",15,17,36,17,1378,150.8,6.42,111.68,"DNA metabolism;other metabolic processes;stress response","nucleus;other cell component","other molecular function","TONSL","ENSG00000160949","","","",1735.6,1768.4,1722.6,1758,1805,2267.3,0.8964547278870727,-0.15769736790302585,0.28474179861300597,0.5455487760053511,0.5178347365171586,0.2858088203134131,4019]
["Q96HE7","ERO1-like protein alpha [OS=Homo sapiens]",47,15,84,13,468,54.4,5.68,301.52,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","ERO1A","ENSG00000197930","Protein processing in endoplasmic reticulum; Vibrio cholerae infection; Lipid and atherosclerosis","Insulin processing; Detoxification of Reactive Oxygen Species","",8825.3,8922.1,8769.5,8106.4,8491.4,6666.4,1.1398156824649033,0.18880054764185042,0.12353621884622304,0.9082056955299038,0.3553428664096986,0.4493523986963002,2541]
["Q96HY7","Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial [OS=Homo sapiens]",10,7,11,7,919,103,6.93,32.57,"other metabolic processes;developmental processes","mitochondrion","other molecular function","DHTKD1","ENSG00000181192","Lysine degradation; Tryptophan metabolism; Metabolic pathways","Glyoxylate metabolism and glycine degradation","Integrated breast cancer pathway",697.8,740.5,718.2,664.1,649,558.4,1.1522842639593909,0.20449666783453876,0.05430364449164685,1.2651710225382695,0.2440992236097459,0.612433601912346,1626]
["Q96I15-1","selenocysteine lyase [OS=Homo sapiens]",20,7,12,7,445,48.1,7.12,36.49,"other metabolic processes","cytosol;ER/Golgi;other cell component","other molecular function","SCLY","ENSG00000132330","Selenocompound metabolism; Metabolic pathways","Metabolism of ingested SeMet, Sec, MeSec into H2Se","",1440.2,1477.7,1466.6,1424.6,1481.6,3511.3,0.6832099727308142,-0.5495990609355718,0.379369519651415,0.4209375653265402,0.5739622892014474,0.24111664092908697,4831]
["Q96IJ6","Mannose-1-phosphate guanyltransferase alpha [OS=Homo sapiens]",32,11,44,11,420,46.3,7.21,135.66,"other metabolic processes","other cell component","other molecular function","GMPPA","ENSG00000144591","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars","Synthesis of GDP-mannose","",4498,4588,4730.5,4441.5,4357.7,5245,0.9837869013542956,-0.02358224848337278,0.8069907881326897,0.09313142275745223,0.8694421684053404,0.060759300122136636,6784]
["Q96IV0","Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase [OS=Homo sapiens]",18,12,23,12,654,74.3,6.89,58.16,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","NGLY1","ENSG00000151092","Protein processing in endoplasmic reticulum","N-glycan trimming in the ER and Calnexin/Calreticulin cycle","",2820.7,2736.9,2938.6,2981.9,2885.8,3108.2,0.9465568912309629,-0.07923887556145744,0.1399474114627656,0.8540351300512222,0.3759190115330223,0.42490570994700694,2721]
["Q96JB2-1","Conserved oligomeric Golgi complex subunit 3 [OS=Homo sapiens]",15,10,13,10,828,94,5.57,37.33,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi","","COG3","ENSG00000136152","","COPI-mediated anterograde transport; Retrograde transport at the Trans-Golgi-Network; Intra-Golgi traffic","",789.3,823.6,844.8,801.7,813.5,883.3,0.9836702021212727,-0.023753394684891238,0.6754302794119842,0.17041947392451084,0.777803672951346,0.10913001035449431,6347]
["Q96JJ7-1","Protein disulfide-isomerase TMX3 [OS=Homo sapiens]",43,17,88,16,454,51.8,4.91,313.97,"protein metabolism;other metabolic processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","TMX3","ENSG00000166479; ENSGGOG00000005485","","Platelet degranulation","",8028.5,8237.7,8325.4,6808.6,7237.5,6445.9,1.2000585594378292,0.2631048069581648,0.005075776472678581,2.2944975116403254,0.07893372391235691,1.1027374076920697,470]
["Q96JQ2","Calmin [OS=Homo sapiens]",10,8,10,8,1002,111.6,4.94,25.17,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;nucleus;other cell component","cytoskeletal activity","CLMN","ENSG00000165959","","","Vitamin D receptor pathway",562.5,581,596,586.1,652.4,614.1,0.9389506639317716,-0.09087873974621555,0.1546818228301057,0.8105607186755702,0.3925588343976537,0.40609524455082807,2880]
["Q96K17-1","transcription factor BTF3 homolog 4 [OS=Homo sapiens]",29,4,19,2,158,17.3,6.35,49.87,"","","","Btf3l4; BTF3L4; LOC108587672; LOC110308160; LOC111143096","ENSAMEG00000009159; ENSANAG00000025045; ENSCAFG00000003782; ENSCANG00000032994; ENSCATG00000029142; ENSCCAG00000034219; ENSCGRG00001021460; ENSCGRG00015007601; ENSCJAG00000021582; ENSCJAG00000023403; ENSCPOG00000036248; ENSECAG00000024180; ENSFCAG00000024164; ENSG00000134717; ENSGGOG00000010677; ENSHGLG00000000408; ENSLCNG00005020988; ENSMFAG00000046175; ENSMLEG00000043474; ENSMMUG00000003636; ENSMNEG00000032806; ENSMODG00000000770; ENSMUSG00000028568; ENSMUSG00000114133; ENSNLEG00000016041; ENSOCUG00000001517; ENSPANG00000025278; ENSPCOG00000026062; ENSPPAG00000025800; ENSPTRG00000000735; ENSRBIG00000044688; ENSRFEG00010003696; ENSRNOG00000008512; ENSSHAG00000025846; ENSSSCG00000038762; ENSSSCG00070030088; ENSSSUG00005008763; ENSSTOG00000006129; ENSTSYG00000033616; ENSUMAG00000022798","","","",649.1,557,545.2,839.2,963.3,434.5,0.7828788556101922,-0.3531390158923713,0.37680229153234523,0.4238864646986229,0.5725671411247217,0.24217357918848167,4810]
["Q96KG9","N-terminal kinase-like protein [OS=Homo sapiens]",35,22,48,22,808,89.6,6.3,144.42,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;kinase activity;other molecular function","SCYL1","ENSG00000142186","","","",5516,5462,5615.4,5291.8,5294.8,4302.1,1.1144962286834983,0.15639173470549828,0.16355809961324883,0.7863279441697575,0.4031858853535365,0.39449467998606585,2965]
["Q96KM6","zinc finger protein 512B [OS=Homo sapiens]",8,5,5,5,892,97.2,9.83,17.38,"","nucleus","nucleic acid binding activity;other molecular function","ZNF512B","ENSG00000196700","","RHOV GTPase cycle","",315.3,297.6,292.1,364.4,357.6,324.9,0.8644569681918044,-0.210133945156813,0.028186835246117082,1.5499536829898477,0.17837019810724655,0.7486777053340378,1155]
["Q96L91-5","Isoform 5 of E1A-binding protein p400 [OS=Homo sapiens]",5,13,17,13,3122,339.5,9.16,50.24,"","","","EP400","","","","",1284,1216.7,1316.7,1548.5,1447.1,2157.1,0.7408543093911929,-0.4327382335767015,0.11743272223810722,0.9302108715098234,0.3470747136426711,0.4595770259871477,2473]
["Q96LT4-1","Sphingomyelin synthase-related protein 1 [OS=Homo sapiens]",3,1,1,1,415,48.3,8.07,3.67,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi","other molecular function","SAMD8","ENSG00000156671; ENSGGOG00000011029; ENSPTRG00000002656","","Sphingolipid de novo biosynthesis","",31.9,30.5,26.2,28.5,23.2,22,1.202170963364993,0.26564207945994844,0.132233407925918,0.8786588092608476,0.36748820476446187,0.4347565958666325,2630]
["Q96LZ7-1","Regulator of microtubule dynamics protein 2 [OS=Homo sapiens]",3,1,1,1,410,47.4,6.54,2.41,"","other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cell component","cytoskeletal activity","RMDN2","ENSG00000115841","","","",31,30.1,33.5,31.9,29.7,34.7,0.9823468328141224,-0.025695614504064337,0.7646955020189509,0.1165114643476131,0.840348733161406,0.07554045029779079,6651]
["Q96MG8-1","Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 [OS=Homo sapiens]",9,4,6,4,357,40.7,5.66,10.9,"protein metabolism;other metabolic processes","other membranes;other cell component","other molecular function","PCMTD1","ENSG00000168300; ENSGGOG00000025636; ENSPPAG00000008533; ENSPPYG00000018582; ENSPTRG00000020242","","","",767.9,735.3,746.9,769.1,745.6,702.2,1.0149758672019487,0.021445425260720977,0.6383263000305379,0.19495726159740437,0.7523829909568136,0.12356103106038215,6201]
["Q96MW5","Conserved oligomeric Golgi complex subunit 8 [OS=Homo sapiens]",17,9,13,9,612,68.4,5.2,41.01,"transport","other membranes;ER/Golgi","","COG8","ENSG00000213380","","COPI-mediated anterograde transport; Retrograde transport at the Trans-Golgi-Network; Intra-Golgi traffic","",676.3,687.3,661.8,740.8,766.3,1032.7,0.7974643672730136,-0.3265080378368152,0.14101858391742836,0.8507236507420469,0.37685734181078023,0.42382301952752355,2735]
["Q96N11","Uncharacterized protein C7orf26 [OS=Homo sapiens]",4,1,2,1,449,50,7.69,4.92,"","","","C7orf26","ENSG00000146576","","","",20.3,22.7,18.9,16.9,20.5,24.2,1.00487012987013,0.007009058519363345,0.9685206918640652,0.01389109640445841,0.9778861357693677,9.711711148933707E-3,7239]
["Q96NC0","Zinc finger matrin-type protein 2 [OS=Homo sapiens]",14,2,2,2,199,23.6,9.01,4.03,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","ZMAT2","ENSG00000146007","Spliceosome","","",134,148.3,171.4,140.3,138.7,81.7,1.2578319933462712,0.33093923656317414,0.23403190803540352,0.6307249266112553,0.4723941496356709,0.32569548954429406,3621]
["Q96ND0","Protein FAM210A [OS=Homo sapiens]",11,3,8,3,272,30.8,9.76,22.34,"","other membranes;mitochondrion;other cell component","","FAM210A","ENSG00000177150","","","",1453.5,1501.4,1439.8,1388.2,1360,1193.9,1.1148119022855838,0.15680031056541247,0.07610596239449521,1.1185813178208455,0.28409523960233174,0.5465360434039914,1958]
["Q96P16-1","Regulation of nuclear pre-mRNA domain-containing protein 1A [OS=Homo sapiens]",25,6,11,5,312,35.7,7.55,38.34,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","LOC111142439; P15RS; RPRD1A","ENSAMEG00000000830; ENSANAG00000021312; ENSBIXG00000008485; ENSBIXG00005019871; ENSBTAG00000005497; ENSCAFG00000017862; ENSCCAG00000025615; ENSCJAG00000021044; ENSDLEG00000001661; ENSG00000141425; ENSGGOG00000007369; ENSLCNG00005017687; ENSMPUG00000001133; ENSNLEG00000006228; ENSOARG00000005585; ENSPCTG00005006209; ENSPPAG00000027698; ENSPPYG00000009111; ENSPTRG00000009974; ENSRFEG00010007667; ENSSBOG00000026758; ENSSSUG00005007348; ENSSTOG00000003343; ENSTSYG00000006414; ENSTTRG00000007088; ENSUMAG00000002096; ENSVVUG00000027590","","RNA polymerase II transcribes snRNA genes; RNA polymerase II transcribes snRNA genes","",402.5,376.8,345.9,467.1,485.1,466.2,0.7932882120699378,-0.3340829835839891,0.005022412802900206,2.299087594559407,0.07827039483240428,1.1064024753905173,469]
["Q96PE3-1","Type I inositol 3,4-bisphosphate 4-phosphatase [OS=Homo sapiens]",32,25,69,25,977,109.9,6.96,235.14,"other metabolic processes;signal transduction","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","INPP4A","ENSG00000040933","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of IP2, IP, and Ins in the cytosol","Insulin signaling",5705.2,5621.9,5748.2,5698.8,5755.4,6536.2,0.9491339825684809,-0.07531633815377692,0.32600209205068575,0.4867796129285229,0.545376354039474,0.26330369575411844,4369]
["Q96PU5","E3 ubiquitin-protein ligase NEDD4-like [OS=Homo sapiens]",11,8,12,5,975,111.9,5.82,32.67,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","NEDD4L","ENSG00000049759","Ubiquitin mediated proteolysis; Endocytosis; Tight junction; Aldosterone-regulated sodium reabsorption","Stimuli-sensing channels; Antigen processing: Ubiquitination & Proteasome degradation; Budding and maturation of HIV virion; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity","TGF-beta signaling pathway",480.5,507.7,493.9,434.4,478.7,567.9,1.000742741390952,0.001071151576308315,0.9931312253850988,2.9933630904107823E-3,0.9951735846366448,2.1011601842002934E-3,7294]
["Q96PZ2","Protein FAM111A [OS=Homo sapiens]",9,4,5,4,611,70.2,8.53,22.54,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","FAM111A","ENSG00000166801","","","",209.3,248.3,242.2,183.8,233.5,332.3,0.9335645677694769,-0.09917828841933757,0.7325473011530411,0.13516432733356312,0.819309598183256,0.08655195736615322,6535]
["Q96QC0","Serine/threonine-protein phosphatase 1 regulatory subunit 10 [OS=Homo sapiens]",20,19,31,19,940,99,9.17,61.29,"transport;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","PPP1R10","ENSG00000204569; ENSG00000206489; ENSG00000227804; ENSG00000230995; ENSG00000231737; ENSG00000235291; ENSG00000238104","","","",4480.3,4370.4,4225.5,4978.2,5265.5,4921,0.8622788449491252,-0.21377360936417186,0.005806388184868376,2.2360939328669427,0.08487778248640591,1.0712059753189884,500]
["Q96QE3-1","ATPase family AAA domain-containing protein 5 [OS=Homo sapiens]",4,4,4,4,1844,207.4,9.19,6.82,"stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ATAD5","ENSG00000176208","","","",161,187.5,168,260.8,289.2,282.7,0.6202714062687642,-0.6890284748706073,8.3807374648919137E-4,3.0767177638468928,0.03646119650648512,1.4381690836887826,168]
["Q96QT6-1","PHD finger protein 12 [OS=Homo sapiens]",3,2,2,2,1004,109.6,7.74,5.82,"other biological processes","nucleus;other cell component","other molecular function","PHF12","ENSG00000109118","","","",73.9,65,58.9,66,84.1,52.2,0.9777558082056352,-0.03245389379917205,0.8903264589115849,0.0504507199760405,0.9247401006373134,0.033980309119462926,7037]
["Q96R06","Sperm-associated antigen 5 [OS=Homo sapiens]",22,16,29,16,1193,134.3,5,88.13,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity","SPAG5","ENSG00000076382","","","",1636,1637,1597.1,1794.8,1756.3,4725.7,0.5884037309104969,-0.7651217005226834,0.3125447354721284,0.5050878119896538,0.5376299062287094,0.2695165811951953,4249]
["Q96RP9","Elongation factor G, mitochondrial [OS=Homo sapiens]",38,27,168,1,751,83.4,7.01,461.06,"protein metabolism;other metabolic processes","mitochondrion","nucleic acid binding activity;other molecular function","GFM1","ENSG00000168827","","Mitochondrial translation elongation","",445.3,410.2,456.7,459.4,406.4,581,0.9069670998064695,-0.1408778768865247,0.4492126332233188,{"$f":"-LOG10(AA5379)","v":0.34754803855923033},0.6170447540366918,{"$f":"-LOG10(AC5379)","v":0.20968333559997976},5321]
["Q96RS0","Trimethylguanosine synthase [OS=Homo sapiens]",11,6,7,6,853,96.6,4.94,20.72,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","TGS1","ENSG00000137574","","Heme signaling; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); RORA activates gene expression; snRNP Assembly","",362.7,350.8,359,389.3,398.7,458.4,0.8604781771501925,-0.216789490787399,0.057321801162699276,1.2416801716813313,0.2507271362646134,0.6007986596907496,1671]
["Q96RT7","gamma-tubulin complex component 6 [OS=Homo sapiens]",2,4,5,4,1819,200.4,6.32,14.98,"cell cycle OR cell proliferation;cell organization and biogenesis","cytosol;cytoskeleton","cytoskeletal activity","TUBGCP6","ENSG00000128159","","Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes","15q11.2 copy number variation syndrome",300.2,294.4,307,384,345.4,348.5,0.8364412283143148,-0.25766392055109943,0.010392203990017734,1.9832923370245619,0.11072393434845425,0.9557584908473405,686]
["Q96S59-1","Ran-binding protein 9 [OS=Homo sapiens]",16,8,14,8,729,77.8,6.79,41.53,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","RANBP9","ENSG00000010017","","RAF/MAP kinase cascade; L1CAM interactions; MET activates RAS signaling","Brain-derived neurotrophic factor (BDNF) signaling pathway; Ciliary landscape",602.6,586.7,617.8,599.9,632.8,2635.3,0.46719234746639093,-1.0979114515827593,0.36515372793838563,0.4375242611876544,0.5665269788795714,0.24677940354191508,4711]
["Q96SB8","structural maintenance of chromosomes protein 6 [OS=Homo sapiens]",18,16,39,16,1091,126.2,6.99,104.02,"cell organization and biogenesis;DNA metabolism;stress response;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMC6","ENSG00000163029","","SUMOylation of DNA damage response and repair proteins","",2499.7,2449.5,2517.9,2402.4,2450.8,2713.2,0.9868761894692323,-0.019058995051583597,0.7541860839436824,0.12252148535154207,0.8338142622212031,0.0789306806285337,6611]
["Q96SK2","Transmembrane protein 209 [OS=Homo sapiens]",15,6,13,6,561,62.9,8.63,35.02,"","other membranes","","TMEM209","ENSG00000146842","","","",1459.8,1453.8,1424.8,1442.1,1503,2114.3,0.8574929833577104,-0.2218032287522928,0.3260635135775637,0.48669779591489176,0.5453542839218336,0.2633212710013407,4370]
["Q96SU4","Oxysterol-binding protein-related protein 9 [OS=Homo sapiens]",18,12,31,12,736,83.1,6.18,87.81,"other metabolic processes;transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","OSBPL9","ENSG00000117859","","Synthesis of bile acids and bile salts","",3885.2,3875,3943.4,3944.6,3654,3240.4,1.0797675062275118,0.11072070709170637,0.23328468066909647,0.6321137795059512,0.47218990058444366,0.3258833060488048,3611]
["Q96SZ5","2-aminoethanethiol dioxygenase [OS=Homo sapiens]",22,4,12,4,270,29.7,6.04,35.36,"","cytosol","other molecular function","ADO","ENSG00000181915","Taurine and hypotaurine metabolism; Metabolic pathways","Degradation of cysteine and homocysteine","",690.9,630.8,667.1,864.8,833.8,1452,0.6312448422522693,-0.6637283999969105,0.127488528782389,0.8945288906075445,0.36116808405832607,0.4422906346868017,2580]
["Q96T66-1","Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 [OS=Homo sapiens]",4,1,1,1,252,28.3,9.22,1.77,"other metabolic processes","mitochondrion;nucleus","other molecular function","NMNAT3","ENSG00000163864","Nicotinate and nicotinamide metabolism; Metabolic pathways; Biosynthesis of cofactors","Nicotinate metabolism","NAD+ metabolism",68,65.8,61.9,56.9,61.1,125.5,0.8036960985626282,-0.3152780163429008,0.5138896610680784,0.2891301197856395,0.6648998995833927,0.1772437326379938,5649]
["Q99081-1","Transcription factor 12 [OS=Homo sapiens]",7,4,4,4,682,72.9,7.02,8.37,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TCF12","ENSG00000140262","","RUNX1 regulates transcription of genes involved in differentiation of HSCs; Myogenesis; NGF-stimulated transcription","",128.1,121.9,141.5,270.7,294.8,254.5,0.47743902439024394,-1.0666116022144052,3.9682763362511466E-4,3.4013980927854117,0.026855677538573732,1.5709638863883881,108]
["Q99439","Calponin-2 [OS=Homo sapiens]",60,13,71,13,309,33.7,7.33,202.24,"cell organization and biogenesis;stress response;developmental processes;other biological processes","non-structural extracellular;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","CNN2","ENSG00000064666","","Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","Myometrial relaxation and contraction pathways; Burn wound healing",8650.1,8676.1,8432.7,9125.7,9593.1,9100.6,0.9259329820197417,-0.11102031825575405,0.018091207948581847,1.7425324343624529,0.14451217365703248,0.8400955665449281,915]
["Q99471-1","prefoldin subunit 5 [OS=Homo sapiens]",44,5,13,5,154,17.3,6.33,46.55,"developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","LOC101567244; PFDN5","ENSCJAG00000018477; ENSG00000123349; ENSGGOG00000026308; ENSMFAG00000003143; ENSMMUG00000022030; ENSNLEG00000017706; ENSPPAG00000037126; ENSPPYG00000004575; ENSPTRG00000005010","","Prefoldin mediated transfer of substrate  to CCT/TriC","Cellular proteostasis",1574.4,1238.6,1145.7,1134.8,1939.2,971.7,0.978495686778555,-0.031362603439374824,0.9334253500825594,0.029920408666769614,0.9561886312198216,0.01945642423346242,7135]
["Q99543-1","dnaJ homolog subfamily C member 2 [OS=Homo sapiens]",35,20,42,20,621,72,8.7,115.84,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;cytosol;nucleus;other cell component","translation activity;other molecular function","DNAJC2","ENSG00000105821","","Regulation of HSF1-mediated heat shock response","",5320.7,4530.1,4769.2,5345.8,5509,4623.6,0.9445420715319413,-0.08231303671870065,0.4699465161049075,0.32795156564346806,0.6331500619743353,0.19849334628006218,5425]
["Q99567","Nuclear pore complex protein Nup88 [OS=Homo sapiens]",29,17,57,17,741,83.5,5.69,186.33,"cell cycle OR cell proliferation;other metabolic processes;transport","cytosol;nucleus","transporter activity;other molecular function","NUP88","ENSG00000108559","Nucleocytoplasmic transport; Amyotrophic lateral sclerosis","HCMV Early Events; ISG15 antiviral mechanism; tRNA processing in the nucleus; HCMV Late Events; Transcriptional regulation by small RNAs; Viral Messenger RNA Synthesis; SUMOylation of DNA damage response and repair proteins; Rev-mediated nuclear export of HIV RNA; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)","Ciliary landscape",5789.6,5874.6,6170.8,5566.2,5504.2,4704.5,1.1305935378354222,0.17708035607781125,0.08435220355692284,1.073903567726757,0.2975532122575044,0.5264353569159794,2072]
["Q99576","TSC22 domain family protein 3 [OS=Homo sapiens]",43,4,5,3,134,14.8,4.54,11.75,"stress response;other biological processes","cytosol;nucleus","","TSC22D3","ENSG00000157514","","Stimuli-sensing channels","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway",471.3,439,424.3,753.2,790.2,501.5,0.6526480512494498,-0.6156228850437617,0.061298055418276785,1.2125533025534838,0.2574870615242443,0.5892445889521105,1740]
["Q99607","ETS-related transcription factor Elf-4 [OS=Homo sapiens]",1,1,1,1,663,70.7,5.6,2.6,"cell cycle OR cell proliferation;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ELF4","ENSG00000102034","","","TYROBP causal network in microglia",78.5,127,80.5,95.6,118,87,0.9514304723885562,-0.07182986225061291,0.8038609398868242,0.09481907346946883,0.8669646760561898,0.0619985972255213,6777]
["Q99638","cell cycle checkpoint control protein rad9a [OS=Homo sapiens]",10,2,5,2,391,42.5,5.66,20.5,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus","other molecular function","RAD9A","ENSG00000172613","Cellular senescence","Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Activation of ATR in response to replication stress; Presynaptic phase of homologous DNA pairing and strand exchange; HDR through Single Strand Annealing (SSA)","Androgen receptor signaling pathway; miRNA regulation of DNA damage response; ATM signaling pathway; ATR signaling; DNA IR-double strand breaks and cellular response via ATM; DNA damage response",138.1,141.2,165.1,125.8,124.4,126.6,1.1794055201698515,0.2380598517763089,0.05793925518408712,1.2370270920028146,0.25192029514603975,0.5987368435583126,1681]
["Q99717","mothers against decapentaplegic homolog 5 [OS=Homo sapiens]",10,5,13,1,465,52.2,7.71,36.7,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMAD5","ENSG00000113658","TGF-beta signaling pathway; Signaling pathways regulating pluripotency of stem cells","Signaling by BMP","Differentiation of white and brown adipocyte; BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation; BMP signaling in eyelid development; Embryonic stem cell pluripotency pathways; Genotoxicity pathway; Neovascularisation processes; Osteoblast differentiation and related diseases; TGF-beta receptor signaling in skeletal dysplasias; Network map of SARS-CoV-2 signaling pathway; TGF-beta receptor signaling",1242.6,1283.1,1373.3,1294.6,1438.7,500,1.2058887205022732,0.2700967813783574,0.4929569225090545,0.30719103028465583,0.6502476351955746,0.18692121856058677,5541]
["Q99732","Lipopolysaccharide-induced tumor necrosis factor-alpha factor [OS=Homo sapiens]",4,1,1,1,161,17.1,6.44,2.51,"other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","LITAF","ENSG00000189067","Lysosome","","Intracellular trafficking proteins involved in CMT neuropathy",556.6,554.6,593.8,483,545.1,748,0.9599684702437927,-0.05894107298057538,0.7844506756508404,0.10543435859853433,0.8537150071965445,0.0686870841805725,6716]
["Q99766-1","ATP synthase subunit s, mitochondrial [OS=Homo sapiens]",5,1,1,1,215,24.9,7.56,2.9,"other metabolic processes;transport","other membranes;mitochondrion;other cell component","transporter activity;other molecular function","DMAC2L","ENSG00000125375","","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",95.1,109.8,100.3,90.2,93.5,63.2,1.2361279870392872,0.3058281256917486,0.13837332093558669,0.858947635943997,0.37444302210966424,0.42661425824747495,2701]
["Q99832","T-complex protein 1 subunit eta [OS=Homo sapiens]",67,29,204,29,543,59.3,7.65,700.66,"transport;other biological processes","cytosol;cytoskeleton;other cell component","other molecular function","CCT7","ENSG00000135624","","Formation of tubulin folding intermediates by CCT/TriC; Association of TriC/CCT with target proteins during biosynthesis; RHOBTB1 GTPase cycle; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate  to CCT/TriC; RHOBTB2 GTPase cycle; Folding of actin by CCT/TriC","VEGFA-VEGFR2 signaling pathway; 16p11.2 proximal deletion syndrome",25599.5,25730.3,26366.9,24108.4,23910.8,21103.7,1.1240370412699703,0.16868957859796,0.045871782049113734,1.3384543878587893,0.22441556559368964,0.6489470234541962,1494]
["Q99856","AT-rich interactive domain-containing protein 3A [OS=Homo sapiens]",21,12,15,12,593,62.9,4.91,37.81,"other biological processes","other membranes;cytosol;nucleus","nucleic acid binding activity;other molecular function","ARID3A","ENSG00000116017","","TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest","",1168.2,1213,1178.3,1251.8,1304.7,1370.3,0.9064632779871651,-0.14167951919692676,0.029337689548185737,1.532574091446519,0.18125881057285675,0.7417008741904763,1183]
["Q99962","Endophilin-A1 [OS=Homo sapiens]",24,8,26,3,352,39.9,5.45,63.46,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SH3GL2","ENSG00000107295","Endocytosis","Golgi Associated Vesicle Biogenesis; MHC class II antigen presentation; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; Lysosome Vesicle Biogenesis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Retrograde neurotrophin signalling","EGF/EGFR signaling pathway",257.1,273.2,281.9,273.3,259.5,487.1,0.7963525835866261,-0.3285207721977913,0.4026369620240113,0.39508635943682974,0.5883393753365651,0.2303720849473405,5002]
["Q99996-2","Isoform 2 of A-kinase anchor protein 9 [OS=Homo sapiens]",29,95,152,1,3907,452.7,4.98,440.93,"cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","AKAP9","ENSG00000127914","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Signaling by BRAF and RAF1 fusions; Phase 3 - rapid repolarisation; Phase 2 - plateau phase","G protein signaling pathways; NO/cGMP/PKG mediated neuroprotection",51.7,55.4,59.6,87,69.6,84.1,0.692563356875779,-0.5299820374880801,0.013483868115600758,1.8701855039222721,0.1266755681965629,0.8973071390279882,778]
["Q9BPZ7","Target of rapamycin complex 2 subunit MAPKAP1 [OS=Homo sapiens]",6,2,2,2,522,59.1,7.55,4.33,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","MAPKAP1","ENSG00000119487","mTOR signaling pathway","PIP3 activates AKT signaling; CD28 dependent PI3K/Akt signaling; Regulation of TP53 Degradation; Constitutive Signaling by AKT1 E17K in Cancer; VEGFR2 mediated vascular permeability","Target of rapamycin (TOR) signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Head and neck squamous cell carcinoma; Interferon type I signaling pathways",124.6,106.1,109.8,111.5,137.3,208.4,0.744750656167979,-0.42517060531504475,0.257987050208688,0.5884020931222604,0.4941371462199425,0.30615249727034505,3816]
["Q9BQ75","Protein CMSS1 [OS=Homo sapiens]",11,2,4,2,279,31.9,9.19,14.34,"","","","CMSS1","ENSG00000184220","","","",613.9,621,553.9,718.7,725.5,180.7,1.1008677457074283,0.13864115911777655,0.7786726151669602,0.10864509856827481,0.8494504692918377,0.07086193938512826,6700]
["Q9BQA9-1","Uncharacterized protein C17orf62 [OS=Homo sapiens]",21,5,25,5,187,20.8,6.8,67.12,"other metabolic processes;stress response","other membranes;ER/Golgi","","C17orf62; CYBC1","ENSG00000178927; ENSGGOG00000001586; ENSPPAG00000037586; ENSPTRG00000009804","","","",3307.4,3635.3,3344.8,3330.1,3147.7,2832.8,1.104923420617361,0.14394638362209633,0.142044692829549,0.847574988043819,0.3776663004333117,0.42289176600331446,2749]
["Q9BQG0","Myb-binding protein 1A [OS=Homo sapiens]",42,43,162,43,1328,148.8,9.28,491.28,"other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MYBBP1A","ENSG00000132382","","B-WICH complex positively regulates rRNA expression","Energy metabolism",13533.7,13472.9,13753.6,19236,18750.8,21339.1,0.6870557378817683,-0.5415009514425934,1.4962547788003907E-3,2.824994449515641,0.046536707141498115,1.3322043499034044,235]
["Q9BRD0","BUD13 homolog [OS=Homo sapiens]",14,7,12,7,619,70.5,9.86,32.44,"RNA metabolism OR transcription;other metabolic processes","nucleus","","BUD13","ENSG00000137656","","","",842.7,832.7,845.3,1060.8,1097,1046.7,0.7866125760649085,-0.3462748431584818,1.2333353135780608E-4,3.9089188333483422,0.01959662566726532,1.7078187031459435,46]
["Q9BRJ2","39S ribosomal protein L45, mitochondrial [OS=Homo sapiens]",43,12,47,12,306,35.3,9.03,113.97,"","other membranes;mitochondrion;translational apparatus","","MRPL45","ENSG00000277936","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",5572.4,5530.5,5729.1,5012.8,5002,5541.4,1.0820123166325968,0.11371692157104397,0.08649158734343658,1.0630261323964718,0.3016063988039971,0.5205594488241879,2096]
["Q9BRP8","Partner of Y14 and mago [OS=Homo sapiens]",9,1,2,1,204,22.6,9.45,7.99,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","translation activity","PYM1","ENSG00000170473","Nucleocytoplasmic transport; mRNA surveillance pathway","","",90.9,59.9,87.1,146,67.2,179.7,0.6054975820819547,-0.7238068960335521,0.21110094292356257,0.6755098268269456,0.4519439929198356,0.3449153817216875,3414]
["Q9BRR6-1","ADP-dependent glucokinase [OS=Homo sapiens]",28,8,22,8,497,54.1,6.2,86.21,"other metabolic processes","non-structural extracellular;other membranes;ER/Golgi","kinase activity;other molecular function","ADPGK","ENSG00000159322; ENSPPAG00000038547; ENSPTRG00000007256","Glycolysis / Gluconeogenesis; Metabolic pathways; Carbon metabolism","Glycolysis","",1948.4,2095.7,1988.1,1895.7,1858.2,1815.7,1.0830580293019245,0.11511054335555534,0.03613185008720909,1.4421098003446564,0.1960561932349007,0.707619434183669,1347]
["Q9BRX5","DNA replication complex GINS protein PSF3 [OS=Homo sapiens]",19,3,3,3,216,24.5,5.34,11.94,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes","nucleus","","GINS3","ENSG00000181938","","Unwinding of DNA","",459.1,460.4,430.5,446.3,507.4,448.6,0.9627041289310417,-0.054835616974486086,0.47708070973765465,{"$f":"-LOG10(AA5571)","v":0.32140814333178785},0.6382908488875193,{"$f":"-LOG10(AC5571)","v":0.19498138196239737},5463]
["Q9BSB4","Autophagy-related protein 101 [OS=Homo sapiens]",19,4,6,4,218,25,6.15,20.06,"cell organization and biogenesis;other metabolic processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","ATG101","ENSG00000123395","Autophagy; Autophagy; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration","Macroautophagy","Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Alzheimer's disease",525.5,514.3,547,596.5,512.2,292,1.132862140358392,0.1799723081819351,0.5340492455435201,0.2724186941292886,0.6762588246149668,0.16988705466677226,5772]
["Q9BSE5","Agmatinase, mitochondrial [OS=Homo sapiens]",12,5,17,5,352,37.6,7.59,48.36,"other metabolic processes","mitochondrion","other molecular function","AGMAT","ENSG00000116771","Arginine and proline metabolism; Metabolic pathways","Agmatine biosynthesis","",2388.4,2351.5,2466.1,2128.8,2055.2,2175.5,1.1331079487381082,0.18028531013507015,4.3946980395646335E-3,2.3570709600113804,0.07540105157553499,1.1226225972301263,426]
["Q9BSJ8","Extended synaptotagmin-1 [OS=Homo sapiens]",36,32,121,32,1104,122.8,5.83,371.03,"cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi","other molecular function","ESYT1","ENSG00000139641","","RAC1 GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; Glycosphingolipid metabolism; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle","",11582.1,11780.2,11920.2,11421.1,11325.1,11635.5,1.0261999842939704,0.037311908561464574,0.08904692921763313,1.0503810525829027,0.30584774701676715,0.5144947143219403,2128]
["Q9BT17-1","Mitochondrial ribosome-associated GTPase 1 [OS=Homo sapiens]",10,3,8,3,334,37.2,9.47,26.68,"other biological processes","other membranes;mitochondrion;translational apparatus","other molecular function","MTG1","ENSG00000148824","","","",479.7,463.3,495.5,421.3,467.8,732,0.8873604342730245,-0.1724078673441129,0.5651351549276882,0.24784767603916208,0.698557897406811,0.15579759315429476,5913]
["Q9BT30","Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial [OS=Homo sapiens]",10,1,1,1,221,24.5,7.11,0,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","mitochondrion","other molecular function","ALKBH7","ENSG00000125652","","","",60.2,67.2,67.3,95,98.1,219.2,0.472228959495513,-1.08244157716777,0.15129709114130765,0.8201694217020139,0.3891028990681976,0.40993553340949185,2842]
["Q9BTC0","Death-inducer obliterator 1 [OS=Homo sapiens]",18,31,59,31,2240,243.7,7.88,180.8,"RNA metabolism OR transcription;other metabolic processes;signal transduction","cytoskeleton;nucleus;other cell component","other molecular function","DIDO1","ENSG00000101191","","","",4984.9,4536.6,4983.2,6515.9,6468.9,8253.1,0.6829630048168605,-0.550120663096435,0.02073690641327924,1.6832560323178862,0.15340693216058499,0.8141550150215414,988]
["Q9BTE3-1","Mini-chromosome maintenance complex-binding protein [OS=Homo sapiens]",19,10,22,10,642,72.9,5.87,64.67,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","MCMBP","ENSG00000197771; ENSGGOG00000006006; ENSPTRG00000003000","","","",2018.9,2050.5,1980.3,2513.5,2607.7,2619,0.7815947908322782,-0.35550724281325846,1.3501673127820743E-4,3.869612410382313,0.02055911018567538,1.6869956858739275,48]
["Q9BTU6","Phosphatidylinositol 4-kinase type 2-alpha [OS=Homo sapiens]",30,15,31,14,479,54,8.29,65.4,"cell organization and biogenesis;other metabolic processes;transport","plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","PI4K2A","ENSG00000155252","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane","Thymic stromal lymphopoietin (TSLP) signaling pathway; Wnt signaling pathway",3516.4,3495.1,3558.9,3044.6,3218.8,2953.2,1.146887138424148,0.19772342723249356,0.004891040550022705,2.310598736569824,0.07721083235446209,1.112321765703804,463]
["Q9BTZ2","dehydrogenase/reductase sdr family member 4 [OS=Homo sapiens]",41,8,10,7,278,29.5,8.56,37.38,"other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle","other molecular function","DHRS4","ENSG00000157326; ENSG00000284807","Retinol metabolism; Metabolic pathways; Peroxisome","Peroxisomal protein import; RA biosynthesis pathway","",1838.8,1914.4,1879.9,1788.5,1679.7,2416.4,0.9572613261734016,-0.06301526995814634,0.7346295270409193,0.13393161999667658,0.8206338396977042,0.0858505784110664,6543]
["Q9BU61-1","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [OS=Homo sapiens]",38,5,23,5,184,20.3,8.22,88.46,"cell organization and biogenesis","other membranes;mitochondrion;nucleus","","NDUFAF3","ENSG00000178057","Thermogenesis","Complex I biogenesis","",1831.8,1747.3,1751.2,2008,1792.1,2170.4,0.8927727995980236,-0.1636350221141162,0.13192154775015064,0.8796842620375321,0.36717996668158837,0.4351210219070197,2626]
["Q9BUE0","Mediator of RNA polymerase II transcription subunit 18 [OS=Homo sapiens]",15,2,3,2,208,23.6,6.54,5.4,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","MED18","ENSG00000130772; ENSG00000284944","","Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression","",140.7,165.8,181.9,148.7,183.5,211.9,0.8976291122955338,-0.1558086280724476,0.44346159217988074,0.35314398806822356,0.6125988994977789,0.21282378771630744,5291]
["Q9BUL5-1","PHD finger protein 23 [OS=Homo sapiens]",5,2,3,2,403,43.8,5.78,6.47,"other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","PHF23","ENSG00000040633; ENSGGOG00000005820; ENSPPAG00000042657","","","",189.3,198.9,212.6,250.6,258.1,1019.8,0.39306509649983645,-1.3471598342600606,0.29237873550698745,0.5340542164877646,0.5228764809935335,0.2816008923153852,4087]
["Q9BUR5-1","MICOS complex subunit MIC26 [OS=Homo sapiens]",32,5,14,5,198,22.3,9.13,45.62,"cell organization and biogenesis;transport","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi","","APOO","ENSG00000184831; ENSGGOG00000001200; ENSNLEG00000010026; ENSPPYG00000020191","","Cristae formation","",1730,1647.2,1694.5,1416.8,1550.8,1104.2,1.2455670710742177,0.3168027096565279,0.06831224912647764,1.1655014156293544,0.2690162871042161,0.5702214256282246,1856]
["Q9BV23","Monoacylglycerol lipase ABHD6 [OS=Homo sapiens]",11,3,3,3,337,38.3,8.41,9.05,"other metabolic processes;other biological processes","plasma membrane;other membranes;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","ABHD6","ENSG00000163686","Retrograde endocannabinoid signaling","Arachidonate production from DAG","",136.5,139.7,144.7,136.4,143.4,1496,0.23701993467732851,-2.076919692090127,0.3742913106561372,0.42679025511345714,0.5716036752164034,0.2429049875069027,4786]
["Q9BV44","THUMP domain-containing protein 3 [OS=Homo sapiens]",9,6,15,6,507,57,6.37,44.86,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","THUMPD3","ENSG00000134077","","","",2196.2,2015.1,2083.8,1995.8,2124.5,704.2,1.3048191522437556,0.3838498633153344,0.3434293450174281,0.46416259841610347,0.5547237751894767,0.2559232200733526,4525]
["Q9BV94-1","ER degradation-enhancing alpha-mannosidase-like protein 2 [OS=Homo sapiens]",5,3,7,3,578,64.7,5.31,14.41,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi","other molecular function","EDEM2","ENSG00000088298","Protein processing in endoplasmic reticulum","ER Quality Control Compartment (ERQC); Maturation of spike protein","",875.9,862.2,809.1,834.8,856.2,783.5,1.0293796726611435,0.041775198789283305,0.4599010842682189,0.33733556652696417,0.6251472986640156,0.2040176411201104,5377]
["Q9BVI4","Nucleolar complex protein 4 homolog [OS=Homo sapiens]",24,8,15,8,516,58.4,7.49,51.37,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","","NOC4L","ENSG00000184967; ENSG00000288146","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",1234.9,1226.5,1212.8,1930.9,1897.3,2223.6,0.6071251528470869,-0.7199341504319305,0.001581649622542552,2.8008897179620003,0.04757315675375932,1.3226380296763394,243]
["Q9BVK2-1","Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase [OS=Homo sapiens]",5,2,4,2,526,60,9.14,10.37,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","ALG8","ENSG00000159063","N-Glycan biosynthesis; Metabolic pathways","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG8 causes CDG-1h","",191.8,234.3,240,167.4,203.1,220.2,1.1276451667513119,0.17331316995172394,0.3122272611257594,0.5055291805829705,0.5379700734484147,0.2692418828795406,4242]
["Q9BVQ7-1","Spermatogenesis-associated protein 5-like protein 1 [OS=Homo sapiens]",29,11,17,11,753,80.7,8.09,54.08,"","cytoskeleton;other cell component","other molecular function","SPATA5L1","ENSG00000171763","","","",400.3,397.1,435.6,359,392.2,674.2,0.865020345166269,-0.2091940297388052,0.559022322028664,0.2525708501809803,0.6939358273959757,0.1586806896264498,5888]
["Q9BW60","Elongation of very long chain fatty acids protein 1 [OS=Homo sapiens]",4,1,1,1,279,32.6,9.6,2.12,"other metabolic processes;developmental processes","other membranes;ER/Golgi","other molecular function","ELOVL1","ENSG00000066322","Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism","Synthesis of very long-chain fatty acyl-CoAs; alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism","Omega-9 fatty acid synthesis",89.6,72.3,68.8,79.3,78,98.5,0.9018764659890539,-0.14899826019865434,0.4161360354238037,0.3807646747187474,0.5954460224965898,0.22515760142615213,5108]
["Q9BW62","katanin p60 ATPase-containing subunit A-like 1 [OS=Homo sapiens]",8,3,4,2,490,55.4,6.74,11.03,"cell organization and biogenesis;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KATNAL1","ENSG00000102781","","","",80.2,95.4,87.1,92.9,85,94.5,0.9643906020558004,-0.052310502878439157,0.5737380978877107,0.24128631073625997,0.7051373394083197,0.1517262873515645,5947]
["Q9BWF3-1","RNA-binding protein 4 [OS=Homo sapiens]",46,15,44,15,364,40.3,7.08,116.4,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RBM14; RBM4","ENSCATG00000036313; ENSG00000173933; ENSGGOG00000014455; ENSMFAG00000052468; ENSMLEG00000024601; ENSMMUG00000020363; ENSMNEG00000014872; ENSNLEG00000035021; ENSPPAG00000033403; ENSPTRG00000003934; ENSRBIG00000043267; ENSRROG00000044302","","Circadian Clock","",5975.5,5987.2,6057.1,4341.3,4349.3,4171,1.4010543011755927,0.486512871913339,1.1048378426460063E-5,4.956701458822187,0.01615051958379932,1.791813501274233,5]
["Q9BWL3","Uncharacterized protein C1orf43 [OS=Homo sapiens]",9,2,2,2,253,28.8,9.6,6.68,"transport","other membranes;mitochondrion;ER/Golgi","","C1orf43","ENSG00000143612","","","",186.7,167.6,149.4,240.2,253.2,247,0.6803079416531604,-0.5557401642123878,0.002290432848717506,2.640082436417452,0.05525007818903053,1.2576671030357842,303]
["Q9BX10","GTP-binding protein 2 [OS=Homo sapiens]",2,1,1,1,602,65.7,8.05,1.96,"protein metabolism;other metabolic processes","non-structural extracellular;other cell component","nucleic acid binding activity;other molecular function","GTPBP2","ENSG00000172432","","Platelet degranulation","Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway",50.3,52.3,62,110.4,82.2,156.9,0.4709585121602289,-1.0863281198411732,0.04922009056452226,1.3078575915345554,0.23269705170510557,0.6332091192328885,1546]
["Q9BXB4","Oxysterol-binding protein-related protein 11 [OS=Homo sapiens]",28,15,32,15,747,83.6,7.06,106.32,"transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","OSBPL11","ENSG00000144909","","RHOH GTPase cycle","",2539.3,2523.7,2568.4,2844.2,2722.2,2097.5,0.9957593392398125,-0.006130989178867004,0.9649391894599177,0.015500055064654968,0.9757527027895045,0.010660237069576242,7228]
["Q9BXF6","Rab11 family-interacting protein 5 [OS=Homo sapiens]",13,7,11,7,653,70.4,9.23,33.04,"cell-cell signaling;transport;other biological processes","other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB11FIP5","ENSG00000135631","Endocytosis","","",1004.2,1019.2,1070.8,1218.1,1257.4,1959.7,0.6976461038961038,-0.5194327112168405,0.13815909021321912,0.8596205352891759,0.3740017742105254,0.4271263375641903,2700]
["Q9BXL7","Caspase recruitment domain-containing protein 11 [OS=Homo sapiens]",14,13,15,13,1154,133.2,6.09,42.42,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","kinase activity;other molecular function","CARD11","ENSG00000198286","NF-kappa B signaling pathway; T cell receptor signaling pathway; B cell receptor signaling pathway","FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; Activation of NF-kappaB in B cells","B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Modulators of TCR signaling and T cell activation; T-cell receptor (TCR) signaling pathway",1019.5,1006.5,1009.1,1108,1116.3,1391.9,0.8393064542890326,-0.2527304196715969,0.10666730220338831,0.9719686888128596,0.33289125183798685,0.4776976176652309,2342]
["Q9BXS9-1","Solute carrier family 26 member 6 [OS=Homo sapiens]",3,3,5,3,759,82.9,8.37,11.45,"stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component","transporter activity;other molecular function","SLC26A6","ENSG00000225697","Mineral absorption; Chemical carcinogenesis","Multifunctional anion exchangers","Proximal tubule transport",893.5,953.9,1004.4,850.8,873.7,1081.8,1.0162135195809427,0.023203562815117155,0.8591609603747409,0.06592546520949169,0.9047122114074313,0.043489547727878115,6941]
["Q9BY12","S phase cyclin A-associated protein in the endoplasmic reticulum [OS=Homo sapiens]",5,6,9,6,1400,158.2,7.44,19.34,"","cytosol;ER/Golgi;nucleus","nucleic acid binding activity;other molecular function","SCAPER","ENSG00000140386","","","",643.4,614.8,621.7,725.9,802,707.4,0.8410056815639958,-0.24981254799016062,0.017212027134591155,1.7641679779279715,0.1424719210948208,0.8462707196215672,883]
["Q9BY43","Charged multivesicular body protein 4a [OS=Homo sapiens]",31,6,11,6,222,25.1,4.7,34.79,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","CHMP4A","ENSG00000254505; ENSG00000285302","Endocytosis; Necroptosis","HCMV Late Events; Late endosomal microautophagy; Pyroptosis; Sealing of the nuclear envelope (NE) by ESCRT-III; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","",1125.2,896.7,861.9,1582,2041.1,2224.5,0.4931595868390451,-1.0198735154543093,0.008997446749224342,2.045880715009751,0.10572723197762171,0.9758131378165968,622]
["Q9BY50","Signal peptidase complex catalytic subunit SEC11C [OS=Homo sapiens]",33,7,57,7,192,21.5,9.2,140.87,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","SEC11C","ENSG00000166562","Protein export","SRP-dependent cotranslational protein targeting to membrane; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP); Synthesis, secretion, and deacylation of Ghrelin","",8246.1,8639.8,8115.3,7946.7,7965.9,9867.3,0.9697942971074365,-0.04424932492194927,0.7126337159789005,0.14713363424826784,0.8059167306343469,0.09370982828696761,6463]
["Q9BYD3","39S ribosomal protein L4, mitochondrial [OS=Homo sapiens]",40,8,16,8,311,34.9,9.72,64.08,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL4","ENSG00000105364","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1652.6,1747.4,1779.4,1558.3,1496.3,1885.4,1.0484615384615383,0.06827393888939247,0.562584439116542,0.24981228443402528,0.6965830366767416,0.15702710577124704,5903]
["Q9BYT3-1","Serine/threonine-protein kinase 33 [OS=Homo sapiens]",20,8,10,8,514,57.8,7.03,25.81,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction","nucleus;other cell component","kinase activity;other molecular function","STK33","ENSG00000130413","","","",690,773.8,784.2,643.6,667.5,778.5,1.0758039816232774,0.10541523356185796,0.3602771357374021,0.4433632986272525,0.5648360328409849,0.24807760592783745,4662]
["Q9BYV9","Transcription regulator protein BACH2 [OS=Homo sapiens]",2,1,1,1,841,92.5,5.1,2.39,"transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","BACH2","ENSG00000112182","","","",78.2,74,81.8,90.4,78.5,180.7,0.6693363844393592,-0.5791966550298318,0.2993874304933228,0.5237664370657164,0.5286839162782547,0.27680390158250334,4139]
["Q9BZ95","Histone-lysine N-methyltransferase NSD3 [OS=Homo sapiens]",4,4,5,1,1437,161.5,8.21,15.42,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","NSD3","ENSG00000147548","Lysine degradation; Metabolic pathways","PKMTs methylate histone lysines","",171.4,210,185.9,204.1,236.1,369.5,0.7006298629121895,-0.5132756135170905,0.1943979003756251,0.7113084300486557,0.43504416835439186,0.3614666485653321,3266]
["Q9BZF1-1","Oxysterol-binding protein-related protein 8 [OS=Homo sapiens]",33,24,60,22,889,101.1,6.96,152,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","OSBPL8","ENSG00000091039; ENSPTRG00000005242","","Acyl chain remodelling of PS","",5655.4,5850.6,5826.3,5497.1,5783,5543.6,1.030231161991714,0.0429680838566008,0.1908494150241852,0.7193091668763064,0.43199701901882,0.36451925000949503,3229]
["Q9BZF2","Oxysterol-binding protein-related protein 7 [OS=Homo sapiens]",6,4,6,4,842,95.4,8.05,24.38,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","OSBPL7","ENSG00000006025","","Synthesis of bile acids and bile salts","",414.2,398.9,414.5,367.7,397.5,401.4,1.052288702211555,0.07353057165272005,0.16060984809335122,0.7942278286621216,0.399420680406364,0.3985694528507613,2939]
["Q9BZL4","Protein phosphatase 1 regulatory subunit 12C [OS=Homo sapiens]",36,18,25,1,782,84.8,5.57,76.28,"signal transduction;other biological processes","cytoskeleton;other cell component","enzyme regulator activity;other molecular function","PPP1R12C","ENSG00000125503","Vascular smooth muscle contraction; Focal adhesion; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Proteoglycans in cancer","","Focal adhesion",24,21.1,29.8,15.1,18.4,34.7,1.0982404692082113,0.13519397943457878,0.7512407696048358,0.12422085107481172,0.831312457992694,0.08023571114138481,6605]
["Q9BZQ6","ER degradation-enhancing alpha-mannosidase-like protein 3 [OS=Homo sapiens]",16,11,22,11,932,104.6,4.93,67.01,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","other molecular function","EDEM3","ENSG00000116406","Protein processing in endoplasmic reticulum","ER Quality Control Compartment (ERQC)","",1540,1543.5,1581.3,2068,2034.8,1794.4,0.7910194668656311,-0.3382148952526023,9.236199752108985E-3,2.0345066831281198,0.10681548099393129,0.9713657995265317,632]
["Q9C037-1","E3 ubiquitin-protein ligase TRIM4 [OS=Homo sapiens]",22,9,14,9,500,57.4,8.1,44.58,"protein metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","TRIM4","ENSG00000146833","","Antigen processing: Ubiquitination & Proteasome degradation; Negative regulators of DDX58/IFIH1 signaling; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; TRAF6 mediated IRF7 activation; TRAF6 mediated NF-kB activation; Ovarian tumor domain proteases; TRAF3-dependent IRF activation pathway","",1107.3,1141.2,1168.2,1044.8,994.2,1105.9,1.0864256415148335,0.11958943518289264,0.06947390669905214,1.1581782789270532,0.27096306513520385,0.5670899035948397,1874]
["Q9C0C9","(E3-independent) E2 ubiquitin-conjugating enzyme [OS=Homo sapiens]",34,34,79,34,1292,141.2,5.12,264.41,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","UBE2O","ENSG00000175931","Ubiquitin mediated proteolysis","Antigen processing: Ubiquitination & Proteasome degradation","",7123.1,7228.7,7395.8,7722.8,7565.1,7149.7,0.9692480479195634,-0.045062170517923564,0.28933142086618396,0.5386044001998808,0.5215100752431414,0.28273729686308263,4055]
["Q9C0J8","pre-mRNA 3' end processing protein WDR33 [OS=Homo sapiens]",23,22,38,22,1336,145.8,9.17,83.97,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","","WDR33","ENSG00000136709","mRNA surveillance pathway","mRNA Splicing - Major Pathway; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs","",2285.5,2198.8,2363,2987.3,3005.9,3473.9,0.7232732304507188,-0.46738733878872407,0.006265886833503482,2.2030174530592914,0.0890999355371147,1.0501226101705943,514]
["Q9GZM5","protein YIPF3 [OS=Homo sapiens]",13,3,4,3,350,38.2,5.76,17.57,"other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","","YIPF3","ENSG00000137207","","","",490.4,500.1,506.2,573.9,549.6,590.7,0.8731186559327967,-0.19575036692794662,0.004772117355289492,2.3212888847569433,0.07632255087485972,1.1173471229428205,457]
["Q9GZS1-2","Isoform 2 of DNA-directed RNA polymerase I subunit RPA49 [OS=Homo sapiens]",32,10,21,10,419,47.2,8.94,68.24,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","POLR1E","ENSG00000137054","RNA polymerase","B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","Pyrimidine metabolism; Eukaryotic transcription initiation; Eukaryotic transcription initiation",2039.8,2109.6,2126.5,2302.3,2165.1,1466.7,1.0575992989669876,0.08079312566362643,0.6839462647935342,0.16497801790031721,0.784520283957304,0.10539582314543815,6372]
["Q9GZT6","Coiled-coil domain-containing protein 90B, mitochondrial [OS=Homo sapiens]",28,8,18,8,254,29.5,7.55,45.98,"","other membranes;mitochondrion","","CCDC90B","ENSG00000137500","","","",1878.8,1827.6,1809.7,1435.1,1775.7,1504,1.1699541868159835,0.22645203771685277,0.06538948864387067,1.1844920588754007,0.26434279452325815,0.5778325231307723,1808]
["Q9GZU8","Protein FAM192A [OS=Homo sapiens]",33,7,10,7,254,28.9,5.45,17.77,"other biological processes","nucleus","","PSME3IP1","ENSG00000172775","","","",1163.7,1006.4,1211,1528.8,1237.5,856.1,0.9333867049469964,-0.09945317702138894,0.7139567167310432,0.1463281163115781,0.8067887511730356,0.0932401656619687,6468]
["Q9GZY8-2","Isoform 2 of Mitochondrial fission factor [OS=Homo sapiens]",40,8,15,4,291,33,7.44,59.29,"","","","MFF","","","","",702.9,670.8,721,885.2,839.7,650.1,0.881978947368421,-0.18118387548740822,0.27239820434880446,0.5647957596226004,0.5075091704270741,0.29455610586816344,3923]
["Q9H078-2","Isoform 2 of Caseinolytic peptidase B protein homolog [OS=Homo sapiens]",32,20,53,20,677,75.4,9.01,157.62,"","","","CLPB","","","","",4854.8,4829.4,5205.8,4931.5,4727,4304.6,1.0663821071252084,0.09272447869566154,0.23456245376102502,0.6297415038547098,0.472421321173693,0.3256705101712934,3629]
["Q9H0D6-1","5'-3' exoribonuclease 2 [OS=Homo sapiens]",43,33,111,33,950,108.5,7.47,358.53,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","XRN2","ENSG00000088930","Ribosome biogenesis in eukaryotes; RNA degradation","Major pathway of rRNA processing in the nucleolus and cytosol; Association of TriC/CCT with target proteins during biosynthesis","mRNA processing",10372.8,10575.1,10535.5,10274.4,11030.1,12195,0.9398170121942119,-0.08954821181944968,0.2978393091480061,0.526017984154547,0.5276072492881184,0.2776892459077069,4126]
["Q9H0H0","integrator complex subunit 2 [OS=Homo sapiens]",9,7,9,7,1204,134.2,6.05,30.57,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","","INTS2","ENSG00000108506","","RNA polymerase II transcribes snRNA genes","",690.6,688.4,652.4,753.6,728.6,945.9,0.8366212264733742,-0.2573534928659846,0.1308891768201333,0.883096263622098,0.3659789569159733,0.43654388498265057,2614]
["Q9H0K6","Pseudouridylate synthase 7 homolog-like protein [OS=Homo sapiens]",9,5,10,5,701,80.6,7.56,31.67,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","PUS7L","ENSG00000129317","","","",715.8,745.2,807.8,896.2,977.3,1128.3,0.7558131787594111,-0.4038984204743426,0.02891462621886201,1.5388824174753752,0.17970833591297825,0.745431777331522,1176]
["Q9H0U3","Magnesium transporter protein 1 [OS=Homo sapiens]",17,8,25,8,335,38,9.63,56.67,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","transporter activity","MAGT1","ENSG00000102158","","Neutrophil degranulation; Maturation of spike protein; Miscellaneous transport and binding events; Asparagine N-linked glycosylation","",2840,2829,2968.3,2494.9,2499.4,4648,{"$f":"AVERAGE(S5890:U5890)/AVERAGE(V5890:X5890)","v":0.8957717557014405},{"$f":"LOG(Y5890,2)","v":-0.15879691714191355},{"$f":"TTEST(V5890:X5890,S5890:U5890,2,2)","v":0.6652297085282279},0.1770283638395156,{"$f":"AA5890*7309/AE5890","v":0.7704268641471745},0.11326858213031822,6311]
["Q9H0U4","ras-related protein Rab-1B [OS=Homo sapiens]",83,15,110,6,201,22.2,5.73,318.85,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","RAB1B","ENSG00000174903","Legionellosis","COPI-mediated anterograde transport; COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs; COPI-dependent Golgi-to-ER retrograde traffic; RAB geranylgeranylation; Golgi Cisternae Pericentriolar Stack Reorganization","",5905.6,6170.2,5597.2,4986.7,5698.4,5384,1.0998126839711,0.13725783018830098,0.11305848137412926,{"$f":"-LOG10(AA5891)","v":0.9466968523737349},0.3410418656060713,{"$f":"-LOG10(AC5891)","v":0.46719230462726813},2423]
["Q9H115","Beta-soluble NSF attachment protein [OS=Homo sapiens]",35,8,33,5,298,33.5,5.47,97.76,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","other membranes;other cytoplasmic organelle;other cell component","other molecular function","NAPB","ENSG00000125814","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Retrograde transport at the Trans-Golgi-Network; Intra-Golgi traffic; COPII-mediated vesicle transport","",562,494,457.3,523.8,508.8,368.9,1.079771673207278,0.11072627465084245,0.5560409179527255,0.25489324836899,0.6927054830946772,0.15945137470134868,5867]
["Q9H1A4","anaphase-promoting complex subunit 1 [OS=Homo sapiens]",7,9,20,9,1944,216.4,6.3,56.12,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","ANAPC1","ENSG00000153107","Cell cycle; Oocyte meiosis; Ubiquitin mediated proteolysis; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection","Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Cyclin B; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Inactivation of APC/C via direct inhibition of the APC/C complex; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Cell cycle",1269.5,1248.2,1318.4,1327.7,1224.9,1026.8,1.0717159300441415,0.09992255446523365,0.3989618213692297,0.39906866211273234,0.5862508951322275,0.23191648116267663,4974]
["Q9H1C4","Protein unc-93 homolog B1 [OS=Homo sapiens]",12,6,36,6,597,66.6,6.96,84.38,"stress response;transport;signal transduction;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding","UNC93B1","ENSG00000110057","","Trafficking and processing of endosomal TLR; UNC93B1 deficiency - HSE","",3072.4,3240.2,3037.6,3008.8,2941.4,2004,1.175504764778356,0.23328038680733032,0.23162635480326918,0.6352120274383429,0.47052724492970943,0.3274152245639025,3598]
["Q9H1K1","Iron-sulfur cluster assembly enzyme ISCU, mitochondrial [OS=Homo sapiens]",20,4,6,4,167,18,9.48,17.48,"cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","ISCU","ENSG00000136003","","","",827.1,804.9,787.6,790.5,885.1,428.7,1.1498360499928717,0.2014281683659056,0.4932498014918258,0.30693308085736676,0.65028189017023,0.18689834057714413,5544]
["Q9H246","Uncharacterized protein C1orf21 [OS=Homo sapiens]",11,1,1,1,121,13.9,5.22,4.29,"","","","C1orf21","ENSG00000116667","","","",63.9,70.6,74.1,68.1,80.8,43.2,1.0858927641853204,0.11888163885423894,0.6558284765825871,0.18320972985302145,0.7641400183870763,0.11682705550638273,6273]
["Q9H269","Vacuolar protein sorting-associated protein 16 homolog [OS=Homo sapiens]",18,12,37,12,839,94.6,6.77,104.51,"cell organization and biogenesis;other metabolic processes;transport","other membranes;other cytoplasmic organelle;other cell component","cytoskeletal activity","VPS16","ENSG00000215305","Salmonella infection","","Ebola virus pathway in host; Network map of SARS-CoV-2 signaling pathway",3200.4,3231.1,3412.4,3141.1,3008.9,3178,1.0553066037735848,0.07766221360580695,0.10921175629810687,0.9617306086955707,0.3360963060138371,0.47353626077248306,2375]
["Q9H2G9-1","Golgin-45 [OS=Homo sapiens]",3,1,1,1,400,44.9,8.54,2.25,"cell organization and biogenesis;transport","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","BLZF1","ENSG00000117475","","Golgi Cisternae Pericentriolar Stack Reorganization","",59.8,55.6,54.6,102.7,107.5,61.2,0.6263817243920413,-0.67488597439379,0.08421619584109653,1.0746043801389056,0.29736047120897324,0.5267167637118504,2070]
["Q9H2H8-1","peptidyl-prolyl cis-trans isomerase-like 3 [OS=Homo sapiens]",39,7,18,7,161,18.1,6.79,51.85,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","CLK1; LOC111141199; PPIL3","ENSAMEG00000005917; ENSCAFG00000011929; ENSECAG00000019985; ENSFCAG00000005373; ENSG00000240344; ENSGGOG00000022268; ENSOCUG00000010661; ENSPPAG00000039183; ENSPPYG00000013062; ENSPTRG00000012793; ENSRFEG00010017851; ENSSSCG00000016096; ENSSSCG00070023158; ENSSSUG00005004462; ENSSTOG00000028255; ENSUMAG00000021460","","mRNA Splicing - Major Pathway; mRNA Splicing - Major Pathway","mRNA Processing",1389.8,1341.5,1290.6,1325.5,1363.2,1218.6,1.0293297161722932,0.04170518212823378,0.5026977328351678,0.2986930734339428,0.6564619848655068,0.18279041845669972,5597]
["Q9H2P9-1","Diphthine methyl ester synthase [OS=Homo sapiens]",15,4,8,4,285,31.6,5.31,21.24,"protein metabolism;other metabolic processes","cytosol","other molecular function","DPH5","ENSG00000117543; ENSPPAG00000030165; ENSPTRG00000001012","","Synthesis of diphthamide-EEF2","",1145.7,1231.6,1211.4,1197.2,1096.9,675.4,1.2085199528540156,0.2732412924215832,0.271502933525504,0.5662254735997893,0.5072635330107128,0.29476635783138017,3912]
["Q9H329","Band 4.1-like protein 4B [OS=Homo sapiens]",1,1,2,1,900,99.7,9.04,2.25,"cell organization and biogenesis;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity","EPB41L4B","ENSG00000095203","Tight junction","","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway",161.5,192.7,182.7,167.3,146,167.2,1.1173777315296567,0.16011697389942486,0.18068020624402253,0.7430894223690573,0.4238098932726446,0.37282890948561115,3116]
["Q9H3E2","Sorting nexin-25 [OS=Homo sapiens]",3,3,4,3,840,97.9,6.38,7.29,"other metabolic processes;transport;other biological processes","other membranes;other cytoplasmic organelle;other cell component","other molecular function","SNX25","ENSG00000109762","","","",404.1,409.8,408.3,407.3,419.9,337.7,1.049188771568375,0.06927427305741045,0.49733922126688135,0.3033472899973963,0.6535513067672843,0.18472031264156408,5562]
["Q9H3P2-1","Negative elongation factor A [OS=Homo sapiens]",38,14,42,14,528,57.2,9.03,144.18,"developmental processes;other biological processes","cytosol;nucleus","other molecular function","NELFA","ENSG00000185049","","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat","Initiation of transcription and translation elongation at the HIV-1 LTR",3137.1,3224.5,3071.4,4012.5,4100.4,4799.8,0.7305211148714057,-0.45300212181748994,0.010147636747049965,1.993635087525921,0.10955550514651137,0.9603657943270922,677]
["Q9H3S7","Tyrosine-protein phosphatase non-receptor type 23 [OS=Homo sapiens]",20,27,56,27,1636,178.9,6.92,172.73,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PTPN23","ENSG00000076201","","Interleukin-37 signaling","",5757.7,5755.3,5907.2,5749.2,5574.5,7359.2,0.93241413270959,-0.1009572231581225,0.5014110971920949,0.29980605849914416,0.655836383209918,0.18320449405731545,5588]
["Q9H3Z4","DnaJ homolog subfamily C member 5 [OS=Homo sapiens]",32,5,14,5,198,22.1,5.07,43.26,"cell-cell signaling;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","DNAJC5","ENSG00000101152","Protein processing in endoplasmic reticulum","Neutrophil degranulation; Sensory processing of sound by inner hair cells of the cochlea; GABA synthesis, release, reuptake and degradation","",1924,1963.2,1957.8,1614.8,1876,979.2,1.307606263982103,0.38692819334833856,0.16068037962529158,0.7940371508700739,0.3991886113804406,0.3988218573776122,2942]
["Q9H488-1","GDP-fucose protein O-fucosyltransferase 1 [OS=Homo sapiens]",9,2,8,2,388,43.9,8.53,26.45,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","POFUT1","ENSG00000101346; ENSPTRG00000013375","Other types of O-glycan biosynthesis","Pre-NOTCH Processing in the Endoplasmic Reticulum","Delta-Notch signaling pathway",404.8,374.7,422.8,391.9,368.3,277,1.1591785576552256,0.2131028134559073,0.21853359261744765,0.6604817945424031,0.46004090680902215,0.3372035491628844,3472]
["Q9H490","Phosphatidylinositol glycan anchor biosynthesis class U protein [OS=Homo sapiens]",11,4,7,4,435,50,7.72,24.74,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;ER/Golgi","","PIGU","ENSG00000101464","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways","Attachment of GPI anchor to uPAR","",1003.8,1071.9,1107.4,852,868.4,995.1,1.1721966488676119,0.2292146180088883,0.04588988975371494,1.338282985657068,0.22435398274909865,0.6490662164335435,1495]
["Q9H4G0-1","Band 4.1-like protein 1 [OS=Homo sapiens]",39,26,63,4,881,98.4,5.62,181.92,"cell organization and biogenesis","plasma membrane;other membranes;cytosol;cytoskeleton","cytoskeletal activity;other molecular function","EPB41L1","ENSG00000088367","","Neurexins and neuroligins; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Trafficking of AMPA receptors","Splicing factor NOVA regulated synaptic proteins",5569.4,5641.4,5832.6,5075.6,4925,4842.4,1.1482449639560737,0.1994304561114101,2.1358730568313807E-3,2.6704245626715384,0.05420519504298806,1.2659590885467962,288]
["Q9H4K7","Mitochondrial ribosome-associated GTPase 2 [OS=Homo sapiens]",9,2,2,2,406,43.9,9.45,8.88,"other biological processes","other membranes;mitochondrion;translational apparatus","other molecular function","MTG2","ENSG00000101181","","","",55.5,53.4,57.5,60,63.9,79.5,0.8180924287118978,-0.2896642457164078,0.1121389598388191,0.9502434765802764,0.3392482025918579,0.46948244464539773,2416]
["Q9H4L7","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 [OS=Homo sapiens]",6,5,11,5,1026,117.3,5.55,27.98,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SMARCAD1","ENSG00000163104","Signaling pathways regulating pluripotency of stem cells","","",852,854,804.9,1003.2,946.8,655.6,0.9636552041756218,-0.053411052380774635,0.7863084892051393,0.10440703554441276,0.8553547771395092,0.06785371475017478,6719]
["Q9H583","HEAT repeat-containing protein 1 [OS=Homo sapiens]",15,31,81,31,2144,242.2,6.54,202.7,"RNA metabolism OR transcription;other metabolic processes;other biological processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity","HEATR1","ENSG00000119285","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",7019.1,7292.6,7374.5,8149,7697.9,6891.1,0.953742633476999,-0.06832808599366216,0.412106586261505,0.3849904445528913,0.5932808822110183,0.22673964607352337,5077]
["Q9H5X1-1","MIP18 family protein FAM96A [OS=Homo sapiens]",28,4,10,4,160,18.3,4.88,28.37,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","CIAO2A","ENSCANG00000036332; ENSCATG00000033389; ENSG00000166797; ENSGGOG00000016550; ENSMFAG00000035924; ENSMLEG00000042755; ENSMMUG00000014004; ENSPANG00000016877; ENSPPAG00000026013; ENSPTRG00000007153; ENSRBIG00000030155; ENSRROG00000031571","","","",627.1,599.3,598.5,663.9,698.2,1075.6,0.7486154982155312,-0.4177031789401072,0.1972680438926223,0.7049432618595043,0.4381136836253955,0.3584131822699048,3291]
["Q9H6A0-1","DENN domain-containing protein 2D [OS=Homo sapiens]",5,2,3,2,471,53.6,7.64,9.16,"","cytosol;nucleus","enzyme regulator activity","DENND2D","ENSG00000162777; ENSPPAG00000037282","","RAB GEFs exchange GTP for GDP on RABs","",110.2,121.1,109.3,116.3,116.6,260.3,0.6905920519059205,-0.5340943647242966,0.3499092808042866,0.4560445383726635,0.559258021735957,0.2523877778693724,4573]
["Q9H6K1","Uncharacterized protein C6orf106 [OS=Homo sapiens]",7,1,2,1,298,32.9,4.58,4.76,"other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","ILRUN","ENSG00000196821","","","",178.6,162.9,164,207.4,240.5,224.8,0.7514493830830979,-0.4122521660409776,0.006730991649423339,2.1719209482356496,0.0928241848408211,1.0323388559524658,530]
["Q9H6P5","Threonine aspartase 1 [OS=Homo sapiens]",12,3,3,3,420,44.4,7.75,6.42,"protein metabolism;other metabolic processes;other biological processes","other cell component","other molecular function","TASP1","ENSG00000089123","","","",145.2,164.9,166.1,142.6,141.7,177.4,1.0314056746805287,0.044611888220967955,0.7396275936745432,0.13098689475861336,0.8238247610739464,0.08416515892466929,6562]
["Q9H6U8","Alpha-1,2-mannosyltransferase ALG9 [OS=Homo sapiens]",6,3,6,3,611,69.8,8.68,22.32,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","ALG9","ENSG00000086848","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG9 causes CDG-1l","",604,598.5,602.6,510.2,559.4,731.2,1.0023878276321634,3.4408006968541863E-3,0.9839591252013495,0.007022942288384852,0.9885576970579607,0.004997978062356767,7275]
["Q9H788","SH2 domain-containing protein 4A [OS=Homo sapiens]",22,8,14,8,454,52.7,8.06,29.96,"other biological processes","cytosol;other cell component","other molecular function","SH2D4A","ENSG00000104611","","","",1585.2,1489.9,1464.3,1698.6,1802.6,2046,0.8183227574271705,-0.2892581212801311,0.03718258580286822,1.4296604112056628,0.1985153540052329,0.7022058974556799,1369]
["Q9H7B4-1","Histone-lysine N-methyltransferase SMYD3 [OS=Homo sapiens]",7,2,9,2,428,49.1,7.25,19.06,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","SMYD3","ENSG00000185420","Lysine degradation; Metabolic pathways","PKMTs methylate histone lysines","Histone modifications",325.1,350.1,414.5,385.1,294.4,389.4,1.0194592571802787,0.027804119014624786,0.8734584470360158,0.05875775084385959,0.9143666269530564,0.03887963343804665,6982]
["Q9H7P6","Multivesicular body subunit 12B [OS=Homo sapiens]",7,1,1,1,319,35.6,8.15,4.5,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MVB12B","ENSG00000196814","Endocytosis","Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Late endosomal microautophagy","",35.3,50.7,58,44.7,30.3,24.9,1.4414414414414412,0.5275122285372561,0.1749501905690841,0.7570855801141609,0.41719769751041946,0.37965809708462184,3065]
["Q9H832","Ubiquitin-conjugating enzyme E2 Z [OS=Homo sapiens]",21,7,11,7,354,38.2,5.62,28.13,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","enzyme regulator activity;other molecular function","UBE2Z","ENSG00000159202","Ubiquitin mediated proteolysis","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation","",2055.1,2041,2037.5,1933.4,1888.7,943.2,1.2871382704131955,0.36416704293265384,0.2306864917630606,0.6369778355808684,0.47005507897859217,0.32785125037286206,3587]
["Q9H871-1","Protein RMD5 homolog A [OS=Homo sapiens]",19,4,10,4,391,44,6.06,36.75,"protein metabolism;other metabolic processes","nucleus;other cell component","other molecular function","LOC111148095; RMD5A; Rmnd5a; RMND5A","ENSAMEG00000009979; ENSBIXG00000016128; ENSBIXG00005012781; ENSBMUG00000001433; ENSBTAG00000021140; ENSCANG00000000502; ENSCATG00000002310; ENSCHIG00000026499; ENSCPOG00000038199; ENSCSAG00000016355; ENSDLEG00000016828; ENSECAG00000020001; ENSG00000153561; ENSHGLG00000004880; ENSLCNG00005014561; ENSMFAG00000065825; ENSMMNG00015005282; ENSMMUG00000003523; ENSMNEG00000044699; ENSMPUG00000009296; ENSMUSG00000002222; ENSNVIG00000017991; ENSOARG00000020715; ENSOCUG00000009371; ENSOGAG00000007229; ENSPANG00000005829; ENSPCOG00000015308; ENSPCTG00005006099; ENSPPYG00000012209; ENSPTRG00000050213; ENSRBIG00000033920; ENSRNOG00000028422; ENSRROG00000038497; ENSSSCG00000035478; ENSSSCG00070028877; ENSSSUG00005017842","","","Ciliary landscape",426.9,370.7,413.6,376.5,427.2,314.8,1.0828788556101923,0.11487185403925053,0.4467088870254425,0.34997540739447486,0.6144138606076325,0.2115389955847606,5314]
["Q9H8M1","Coenzyme Q-binding protein COQ10 homolog B, mitochondrial [OS=Homo sapiens]",3,1,1,1,238,27.1,9.6,2.4,"other metabolic processes","other membranes;mitochondrion","other molecular function","COQ10B","ENSG00000115520","","Respiratory electron transport","",93.2,78.9,97.9,112.2,120.4,189.9,{"$f":"AVERAGE(S6082:U6082)/AVERAGE(V6082:X6082)","v":0.6390532544378698},{"$f":"LOG(Y6082,2)","v":-0.6459919341187159},{"$f":"TTEST(V6082:X6082,S6082:U6082,2,2)","v":0.11490923753958314},0.9396450570279163,{"$f":"AA6082*7309/AE6082","v":0.343365338175312},0.46424354784421007,2446]
["Q9H8T0-1","AKT-interacting protein [OS=Homo sapiens]",11,3,4,3,292,33.1,9.31,11.58,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","AKTIP; FTS","ENSCSAG00000005299; ENSG00000166971; ENSGGOG00000014821; ENSMNEG00000035738; ENSNLEG00000031116; ENSPANG00000018701; ENSPTRG00000008116; ENSRROG00000038050; ENSSBOG00000028267","","","",415.8,410.2,408.9,486.9,446.2,359.6,0.9552873829968286,-0.06599328461405905,0.635323304574482,0.19700521382502298,0.7506592358769625,0.12455716760821013,6186]
["Q9H936","Mitochondrial glutamate carrier 1 [OS=Homo sapiens]",7,2,6,2,323,34.4,9.29,22.94,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","SLC25A22","ENSG00000177542","","Organic anion transporters","",1193.2,1261.3,1365.5,1191.8,1113.2,1792.1,0.9323667960264577,-0.10103046757731338,0.6963974889333209,0.15714280352881405,0.7943148012817793,0.10000734472102236,6408]
["Q9H999","Pantothenate kinase 3 [OS=Homo sapiens]",13,4,9,2,370,41.1,6.55,21.39,"other metabolic processes","cytosol;nucleus","kinase activity;other molecular function","PANK3","ENSG00000120137","Pantothenate and CoA biosynthesis; Metabolic pathways; Biosynthesis of cofactors","Coenzyme A biosynthesis","",54.4,52.5,47.6,71.6,68,60.3,0.7728864432216109,-0.3716716339528905,0.017838245967085456,1.7486478519927917,0.1432744393114589,0.8438312824299122,910]
["Q9H9A7","RecQ-mediated genome instability protein 1 [OS=Homo sapiens]",7,3,3,3,625,70.1,4.96,10.08,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","nucleus;other cell component","other molecular function","RMI1","ENSG00000178966","Fanconi anemia pathway","Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function","",110.8,101.5,95.5,114.5,121,189,0.725088339222615,-0.4637713221121904,0.18375568041092896,0.7357592267581051,0.42786564769782726,0.36869258057417464,3139]
["Q9H9J4-1","Ubiquitin carboxyl-terminal hydrolase 42 [OS=Homo sapiens]",2,2,2,2,1324,145.3,8.63,5.63,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","USP42","ENSG00000106346","","Ub-specific processing proteases","",58.6,55.4,51.5,63.8,67.5,198.3,0.5021237864077669,-0.9938850254886387,0.28428104501584267,0.546252096762114,0.51764079671669,0.2859715030296078,4014]
["Q9H9T3","elongator complex protein 3 [OS=Homo sapiens]",20,10,24,10,547,62.2,8.88,76.04,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","ELP3","ENSG00000134014","","HATs acetylate histones","Ethanol effects on histone modifications",2354.9,2400.1,2306.6,2721.4,2688.5,2101,0.9401802713389874,-0.08899068742530543,0.5022696413171319,0.2990630711076178,0.656489414947589,0.18277227196126986,5592]
["Q9HA64","Ketosamine-3-kinase [OS=Homo sapiens]",28,8,20,8,309,34.4,7.33,43.08,"protein metabolism;other metabolic processes","cytosol","kinase activity;other molecular function","FN3KRP","ENSG00000141560","","Gamma carboxylation, hypusine formation and arylsulfatase activation","",2304.1,2416.9,2206.4,2250.9,2219.8,3886.1,0.8289536664752056,-0.2706366288895378,0.43800748155213176,0.358518471301706,0.6089778738186287,0.21539848643615828,5257]
["Q9HAF1","Chromatin modification-related protein MEAF6 [OS=Homo sapiens]",18,2,3,2,191,21.6,9.32,11.04,"protein metabolism;other metabolic processes","nucleus;other cell component","","MEAF6","ENSG00000163875","","HATs acetylate histones; Regulation of TP53 Activity through Acetylation","",28.4,33.9,32.6,31,43.9,80.8,0.609505459216442,-0.7142889520579274,0.24839835911853592,0.6048512773687226,0.4850503892058186,0.31421314259917144,3743]
["Q9HAP2-1","MLX-interacting protein [OS=Homo sapiens]",2,1,1,1,919,101.1,8.35,0,"other biological processes","other membranes;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","MLXIP","ENSG00000175727; ENSG00000281178","Insulin resistance; Non-alcoholic fatty liver disease","","Nonalcoholic fatty liver disease",18.3,20.7,17,22.4,16.8,27.4,0.8408408408408409,-0.25009535012629563,0.33778584527700123,0.47135855324603254,0.5514578385368778,0.2584876857455047,4477]
["Q9HAW4","Claspin [OS=Homo sapiens]",1,1,1,1,1339,151,4.82,2.74,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","ER/Golgi;nucleus","nucleic acid binding activity;other molecular function","CLSPN","ENSG00000092853","","Ub-specific processing proteases; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Apoptotic cleavage of cellular proteins","",15.6,15.7,20.1,21.7,21,56.1,0.520242914979757,-0.9427426823907996,0.24753853917678634,0.6063571763310914,0.48440674239441267,0.3147898205985361,3735]
["Q9HB90","ras-related GTP-binding protein C [OS=Homo sapiens]",34,9,14,5,399,44.2,5.1,41.02,"RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RRAGC","ENSG00000116954","Autophagy; mTOR signaling pathway; Shigellosis","Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Macroautophagy; mTORC1-mediated signalling; Amino acids regulate mTORC1; Energy dependent regulation of mTOR by LKB1-AMPK","Target of rapamycin (TOR) signaling",1431.9,1449.4,1592.9,1354.1,1175,810.3,1.3398215248248193,0.4220408347136722,0.08740297280358279,1.0584737956237757,0.3033372878544096,0.5180742005892706,2106]
["Q9HBH5","Retinol dehydrogenase 14 [OS=Homo sapiens]",34,9,27,9,336,36.8,8.79,85.2,"other metabolic processes","other membranes;cytosol;ER/Golgi;nucleus","other molecular function","RDH14","ENSG00000240857","","RA biosynthesis pathway","",2661.3,2784.5,2632.6,2603.7,2663.9,2761.4,1.006152696475277,0.008849269090313508,0.8137169155026587,0.08952665582065107,0.8741118364798549,0.05843299887720947,6804]
["Q9HBR0","Putative sodium-coupled neutral amino acid transporter 10 [OS=Homo sapiens]",16,16,33,16,1119,119.7,5.73,90.23,"transport;developmental processes","other membranes;ER/Golgi","transporter activity","SLC38A10","ENSG00000157637","","","",4162.2,3869.2,4025.3,4051.9,4349.2,5987.7,0.8379225508729012,-0.2551111930096074,0.2700544409766388,0.568548676461699,0.5053322859954564,0.2964229535295617,3906]
["Q9HC52","chromobox protein homolog 8 [OS=Homo sapiens]",22,7,17,7,389,43.4,9.91,39.61,"protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","CBX8","ENSG00000141570","","SUMOylation of DNA damage response and repair proteins; SUMOylation of RNA binding proteins; SUMOylation of chromatin organization proteins; SUMOylation of transcription cofactors; Oxidative Stress Induced Senescence; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN gene transcription","",1204.1,1137.3,1078.5,1282.9,1176.7,1419.3,0.8816674830493177,-0.18169344251343522,0.12496639770916615,0.9032067490024386,0.3577670978677225,0.4463996019227158,2553]
["Q9HCC9-1","Lateral signaling target protein 2 homolog [OS=Homo sapiens]",6,3,3,3,887,96.4,5.11,10.56,"other biological processes","other membranes;cytosol;other cytoplasmic organelle","other molecular function","ZFYVE28","ENSG00000159733","","","",48.6,49.4,50.7,53.8,46.8,81.2,0.8179317931793179,-0.2899475521416886,0.35322174381213595,0.4519525697406612,0.5613606709116986,0.25075801743072584,4599]
["Q9HCJ1","progressive ankylosis protein homolog [OS=Homo sapiens]",5,2,5,2,492,54.2,7.88,10.25,"transport;developmental processes;other biological processes","plasma membrane;other membranes","transporter activity","ANKH","ENSG00000154122","","Miscellaneous transport and binding events","",456,450,472.9,412.9,399.6,276.7,1.2659750275431512,0.34024894663435024,0.09264466770059612,1.0331795720801076,0.3120460259095194,0.5057813440446641,2170]
["Q9HCK8-1","Chromodomain-helicase-dna-binding protein 8 [OS=Homo sapiens]",5,11,13,5,2581,290.3,6.47,32.73,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CHD8","ENSG00000100888","Wnt signaling pathway","Deactivation of the beta-catenin transactivating complex","lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Malignant pleural mesothelioma",941.7,921.7,939,1070.5,1104.5,947.3,0.8975434775646158,-0.15594626921337712,0.09121411654242517,1.0399379438859513,0.3089360416165828,0.5101314223488702,2158]
["Q9HD26-1","Golgi-associated PDZ and coiled-coil motif-containing protein [OS=Homo sapiens]",18,8,12,8,462,50.5,5.92,36.97,"transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","GOPC","ENSG00000047932","","RHOQ GTPase cycle; RHO GTPases regulate CFTR trafficking","",1683.1,1602.3,1719.1,2322.7,2081.8,2007.2,0.7805262254940188,-0.3574809876623605,0.009794052391726088,2.0090375771223057,0.10879138135429481,0.963405508852288,658]
["Q9HDC9","Adipocyte plasma membrane-associated protein [OS=Homo sapiens]",50,18,71,18,416,46.5,6.16,226.63,"other metabolic processes","other membranes;other cell component","other molecular function","APMAP","ENSG00000101474","","","Ciliary landscape",9955.4,10420,10441.7,9063.3,9090.1,9211.9,1.126137846104373,0.17138343285264296,2.2270800190533962E-3,2.6522641784715693,0.05462324784987004,1.2626224806638515,298]
["Q9NNX1","tuftelin [OS=Homo sapiens]",5,2,2,2,390,44.2,6,2.63,"developmental processes;signal transduction","non-structural extracellular;other cell component","extracellular structural activity;bone, tooth or skin structural activity","TUFT1","ENSG00000143367","","","",207.5,203.8,202.2,214.6,225.7,605.2,0.5868005738880918,-0.7690578129266744,0.3248498864628933,0.48831728068727664,0.5444457280800934,0.2640454054767301,4361]
["Q9NP80-1","Calcium-independent phospholipase A2-gamma [OS=Homo sapiens]",8,6,10,5,782,88.4,9.23,22.81,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle","other molecular function","IPLA2(GAMMA); PNPLA8","ENSG00000135241","","Acyl chain remodelling of PC; Acyl chain remodelling of PE","Eicosanoid synthesis",824.3,844,822.2,783.9,762.1,313.4,1.339410562547058,0.4215982502525776,0.24238213294988573,0.6154993970769608,0.4798404685077776,0.3189031275468622,3692]
["Q9NPF5","DNA methyltransferase 1-associated protein 1 [OS=Homo sapiens]",14,6,7,6,467,53,9.5,18.39,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","DMAP1","ENSG00000178028","","HATs acetylate histones","",534.3,465.2,536,591.5,574.2,645.8,0.8476400772840187,-0.23847629347741311,0.04429185871943062,1.3536760940513433,0.22022394243559074,0.6571354669155464,1470]
["Q9NPI1-1","Bromodomain-containing protein 7 [OS=Homo sapiens]",30,17,35,17,651,74.1,6.39,99.61,"cell-cell signaling;cell cycle OR cell proliferation;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","BRD7","ENSG00000166164","Hepatocellular carcinoma","Regulation of TP53 Activity through Acetylation","",2993.2,2764.4,2918.5,3309.3,3424.7,3028.7,0.8886988230714863,-0.17023351731627936,0.05564277068636767,1.2545912528021776,0.24692957555960007,0.6074268900879589,1647]
["Q9NPR2-1","Semaphorin-4B [OS=Homo sapiens]",1,1,1,1,832,92.1,6.95,2.25,"","","","","","","","",140.6,131,114.2,138.9,148.4,239.4,0.7324852857414086,-0.44912831610485365,0.22717932922070894,0.6436311871061905,0.4694525635493813,0.3284082850369691,3537]
["Q9NQ25-7","Isoform 7 of SLAM family member 7 [OS=Homo sapiens]",32,4,13,1,188,21.3,6.02,48.57,"","","","SLAMF7","","","","",36.4,39.6,45.4,18.6,19.7,31.5,1.7392550143266476,0.7984694800460299,0.024627517212482197,1.6085793687239724,0.1657481798398088,0.7805512320928276,1086]
["Q9NQ88","Fructose-2,6-bisphosphatase TIGAR [OS=Homo sapiens]",23,5,11,5,270,30,7.69,35.58,"other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","other molecular function","TIGAR","ENSG00000078237","Fructose and mannose metabolism; Metabolic pathways; Central carbon metabolism in cancer","TP53 Regulates Metabolic Genes","Genotoxicity pathway; Metabolic reprogramming in colon cancer; p53 transcriptional gene network",1018.6,999.7,1061.5,920.3,915.5,556.2,1.287541806020067,0.36461927684625844,0.13328727499132093,0.8752113109375839,0.36859504082919586,0.4334505121853212,2643]
["Q9NQL2-1","Ras-related GTP-binding protein D [OS=Homo sapiens]",13,5,8,1,400,45.6,4.92,24.01,"stress response;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RRAGD","ENSG00000025039; ENSGGOG00000024195; ENSNLEG00000013157; ENSPPAG00000029815; ENSPTRG00000018420","Autophagy; mTOR signaling pathway; Shigellosis","Amino acids regulate mTORC1; TP53 Regulates Metabolic Genes; Regulation of PTEN gene transcription; mTORC1-mediated signalling; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK","Target of rapamycin (TOR) signaling",42.1,47.2,48.6,43,32,65.6,0.980796586059744,-0.027974137558554896,0.9331835513929595,0.030032924831381348,0.9560749337161677,0.019508067949743642,7134]
["Q9NQS7","Inner centromere protein [OS=Homo sapiens]",17,16,29,15,918,105.4,9.44,76.56,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity","INCENP","ENSG00000149503","","SUMOylation of DNA replication proteins; Separation of Sister Chromatids; RHO GTPases Activate Formins; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",2305.8,2044.1,2247.1,2085.4,2243.2,2064.1,1.0319583274672672,0.0453847130381085,0.5227443720350305,0.281710634181812,0.6701874434667668,0.17380371330197106,5701]
["Q9NQW7-3","Isoform 3 of Xaa-Pro aminopeptidase 1 [OS=Homo sapiens]",42,21,59,20,666,74.8,5.88,197.11,"","","","XPNPEP1","","","","",5525.2,5651.1,5608,5401.5,5392.6,5708.2,1.0170885270538046,0.024445256366603333,0.4414576686274168,0.3551109345845562,0.6112169160821727,0.2138046347015417,5279]
["Q9NR28-1","Diablo homolog, mitochondrial [OS=Homo sapiens]",32,8,22,7,239,27.1,5.9,68.42,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion","","DIABLO","ENSG00000184047","Apoptosis; Apoptosis","Regulation of the apoptosome activity; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Release of apoptotic factors from the mitochondria","TNF-alpha signaling pathway; Nanomaterial induced apoptosis; Apoptosis; Complement system in neuronal development and plasticity",2607.2,2750.7,2625.9,2696.4,2651.3,2392.3,1.0314987080103357,0.04474201419749616,0.48179742797194297,0.317135522769751,0.6423672749082325,0.19221659208925765,5482]
["Q9NR34","mannosyl-oligosaccharide 1,2-alpha-mannosidase IC [OS=Homo sapiens]",1,1,1,1,630,70.9,7.46,2.08,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","MAN1C1","ENSG00000117643","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum","Intra-Golgi traffic; Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2","",111.8,124.7,137.2,139.2,127.3,129.3,0.9441637190500252,-0.0828910486667677,0.4199719929382926,0.37677967083523733,0.5976587415081739,0.22354672401206116,5136]
["Q9NRA0-1","Sphingosine kinase 2 [OS=Homo sapiens]",2,1,3,1,654,69.2,6.95,7.09,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","SPHK2","ENSG00000063176","Sphingolipid metabolism; Metabolic pathways; Calcium signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; VEGF signaling pathway; Apelin signaling pathway; Fc gamma R-mediated phagocytosis; Tuberculosis","Sphingolipid de novo biosynthesis","Sphingolipid pathway; S1P receptor signal transduction; Metabolism of spingolipids in ER and Golgi apparatus; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway",116,133.8,114,123.5,138.6,185.1,0.8135062611806796,-0.2977746451917041,0.22859429088911745,0.6409346202500739,0.4702492744465408,0.3276718658554288,3553]
["Q9NRB3","carbohydrate sulfotransferase 12 [OS=Homo sapiens]",18,5,8,5,414,48.4,9.32,35.01,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","CHST12","ENSG00000136213","Glycosaminoglycan biosynthesis","Chondroitin sulfate biosynthesis","Metapathway biotransformation Phase I and II",623.1,616,633.8,825,830.8,681.3,0.8013777758760857,-0.3194455939506229,0.03461318415079764,1.4607584470649382,0.19326796253489686,0.7138401317317209,1309]
["Q9NRG7-1","Epimerase family protein sdr39u1 [OS=Homo sapiens]",5,1,3,1,319,34.7,9.77,10.09,"","","","","","","","",131.3,128.1,141.4,120.2,107.4,127.8,1.1277433877321326,0.17343882716652995,0.10261855175220164,0.9887741188023015,0.3272421443092678,0.48513077021368084,2292]
["Q9NRP0-1","oligosaccharyltransferase complex subunit OSTC [OS=Homo sapiens]",13,2,19,2,149,16.8,9.13,58.98,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","DC2; OSTC","ENSANAG00000024765; ENSCANG00000031432; ENSCATG00000035272; ENSCCAG00000023668; ENSCJAG00000042857; ENSG00000198856; ENSGGOG00000026873; ENSMFAG00000034553; ENSMLEG00000037144; ENSMMUG00000011902; ENSNLEG00000012929; ENSOGAG00000033684; ENSPANG00000016693; ENSPPAG00000043858; ENSPTRG00000024222; ENSRBIG00000031965; ENSRROG00000031431","","","",1425.2,1520.2,1447.6,1141.9,1183.3,1490.4,1.1513261348149701,0.20329656190896087,0.1654558629887616,0.7813178388483276,0.40553886739934897,0.39196751608133035,2982]
["Q9NRR8","CDC42 small effector protein 1 [OS=Homo sapiens]",10,1,1,1,79,8.9,9.99,2.02,"transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","CDC42SE1","ENSG00000197622","","","",47.3,43.9,45.5,64.4,81.8,244.7,0.34970580711179333,-1.5157863416832305,0.21412112551055437,0.6693404824484304,0.4554747690211414,0.34153567572366206,3436]
["Q9NRX2","39S ribosomal protein L17, mitochondrial [OS=Homo sapiens]",9,2,4,2,175,20,10.11,9.19,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL17","ENSG00000158042","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",705.1,607.8,598.9,738.5,868.6,1117.5,0.701680980694414,-0.5111128366937926,0.08023643299048591,1.0956283866549197,0.2914751932045037,0.5353984011548365,2012]
["Q9NS00-1","Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 [OS=Homo sapiens]",18,6,13,6,363,42.2,6.64,40.84,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","C1GALT1","ENSG00000106392","Mucin type O-glycan biosynthesis; Other types of O-glycan biosynthesis; Metabolic pathways","O-linked glycosylation of mucins; Defective C1GALT1C1 causes TNPS","Ectoderm differentiation",1062.7,1138.5,1051.5,1153.8,1181.2,3274.5,0.5798556021035743,-0.7862344154497879,0.32631368970214797,0.486364706054637,0.545398298201006,0.26328622151552106,4373]
["Q9NS69","Mitochondrial import receptor subunit TOM22 homolog [OS=Homo sapiens]",63,5,47,5,142,15.5,4.34,200.86,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity","TOMM22","ENSG00000100216","","Mitochondrial protein import; PINK1-PRKN Mediated Mitophagy","",3499.4,3458.9,3344,2740,3276,3195.1,1.1184657641324054,0.16152109665422743,0.10363971050332556,0.9844738087987547,0.3284920399257617,0.4834751498734619,2306]
["Q9NSD4","zinc finger protein 275 [OS=Homo sapiens]",3,1,1,1,429,48.4,9.09,2.04,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF275","ENSG00000063587","","","",87.8,99,93.7,275.1,276.2,226.4,0.36067892503536075,-1.4712129679505408,0.000583564288184823,3.2339112930616887,0.03136228957605053,1.503592239547933,136]
["Q9NSG2-1","Uncharacterized protein C1orf112 [OS=Homo sapiens]",4,2,2,2,853,96.5,6,6.63,"","","","C1orf112","ENSG00000000460","","","",67.7,59,70.4,67.3,76.5,696.2,0.23464285714285715,-2.0914615515099992,0.36139320874883346,0.44202001290020887,0.5646479185004754,0.24822226848937015,4678]
["Q9NSY1","BMP-2-inducible protein kinase [OS=Homo sapiens]",8,6,8,6,1161,129.1,6.51,19.35,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","BMP2K","ENSG00000138756","Transcriptional misregulation in cancer","","",713.2,742.6,692.8,777.9,781.7,678.7,0.9599249430371266,-0.059006489617537954,0.46079443701781697,0.3364927726122933,0.6256634850758358,0.20365919054400825,5383]
["Q9NTN3","UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter [OS=Homo sapiens]",2,1,3,1,355,39.2,8.97,6.69,"transport","other membranes;ER/Golgi","transporter activity","SLC35D1","ENSG00000116704","","Formation of the active cofactor, UDP-glucuronate; Transport of nucleotide sugars; Defective SLC35D1 causes SCHBCKD","",306.6,365.4,298.6,327.3,320.9,389.7,0.9351575296271317,-0.09671868382407661,0.5017069257964901,0.2995499037272065,0.6559885367882909,0.18310374972965682,5590]
["Q9NTX7","E3 ubiquitin-protein ligase rnf146 [OS=Homo sapiens]",9,3,3,3,359,38.9,5.33,4.98,"cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","RNF146","ENSG00000118518","","Degradation of AXIN; Ub-specific processing proteases; Regulation of PTEN stability and activity","",147.8,153.8,154.9,165.1,168,286.6,0.7366467645634983,-0.4409551081000259,0.24628348502408914,0.6085647095712875,0.4828556845603722,0.31618265136925827,3728]
["Q9NUL5","Repressor of yield of DENV protein [OS=Homo sapiens]",4,1,3,1,291,33.1,7.25,8.25,"stress response;other biological processes","cytosol;nucleus;other cell component","translation activity;nucleic acid binding activity;other molecular function","SHFL","ENSG00000130813","","","",329,319.3,335.8,306.5,323.5,516.2,0.8585761647181992,-0.2199819727889818,0.4677570520353626,0.3299796562342437,0.6318307694190474,0.19939922828285245,5411]
["Q9NUQ2","1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [OS=Homo sapiens]",35,12,28,12,364,42,9.1,77.29,"other metabolic processes;developmental processes","other membranes;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","AGPAT5","ENSG00000155189; ENSG00000284980","Glycerolipid metabolism; Glycerophospholipid metabolism; Metabolic pathways; Phospholipase D signaling pathway","Synthesis of PA","Triacylglyceride synthesis",2809.8,2979.9,2996.7,2689.9,2644.4,2252.9,1.158055672711936,0.2117046115436939,0.057154207343614226,1.2429517939850798,0.25029364977500085,0.6015501687803535,1669]
["Q9NUQ3-1","Gamma-taxilin [OS=Homo sapiens]",22,10,16,9,528,60.5,7.52,45.14,"cell cycle OR cell proliferation;other biological processes","other membranes;cytosol;nucleus","other molecular function","TXLNG","ENSG00000086712","","","",1461.8,1153,1376.4,1844.5,1739.6,825.1,0.9051982218996644,-0.14369434419667088,0.7001249698503462,0.15482443302533253,0.7964534481924017,0.09883960314469167,6425]
["Q9NUU7","ATP-dependent RNA helicase DDX19A [OS=Homo sapiens]",49,21,55,4,478,53.9,6.58,145.47,"other metabolic processes;transport","nucleus;other cell component","nucleic acid binding activity;other molecular function","DDX19A","ENSG00000168872","Nucleocytoplasmic transport; mRNA surveillance pathway","","",7488.6,7411.1,7421.6,7095.5,7217,6640.4,1.065308382133261,0.09127111775046737,0.061673242039153676,1.209903220980116,0.25758270060809957,0.5890833077824373,1750]
["Q9NUY8","TBC1 domain family member 23 [OS=Homo sapiens]",16,8,13,8,699,78.3,5.41,44.18,"cell organization and biogenesis;transport;developmental processes","cytosol;ER/Golgi;other cell component","","TBC1D23","ENSG00000036054","","","",671.2,679.8,715.6,707,665.3,937,0.8949032174251936,-0.16019642959507305,0.39795358333030845,0.4001675803863561,0.5860654323113489,0.23205389369970644,4963]
["Q9NV96","Cell cycle control protein 50A [OS=Homo sapiens]",24,7,26,7,361,40.7,8.59,87.23,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity","TMEM30A","ENSG00000112697","","Neutrophil degranulation","",2175.1,2361.9,2491.6,2430.2,2639.5,2131.8,0.9759911129625773,-0.035060083721322466,0.7565714936916055,0.12115002620169829,0.8354405570919995,0.07808444540592904,6619]
["Q9NVG8","TBC1 domain family member 13 [OS=Homo sapiens]",26,9,11,9,400,46.5,5.24,34.76,"transport;other biological processes","other membranes;cytosol","enzyme regulator activity;other molecular function","TBC1D13","ENSG00000107021","","TBC/RABGAPs","",1038.4,1019.3,991.8,1000.8,1057,1085.8,0.9700661661789031,-0.04384494102819286,0.33117548440161904,0.47994181978318623,0.5476383745455733,0.2615061272483051,4420]
["Q9NVH2","Integrator complex subunit 7 [OS=Homo sapiens]",13,8,13,8,962,106.8,8.02,34.41,"RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","","INTS7","ENSG00000143493","","RNA polymerase II transcribes snRNA genes","",664.9,698.6,703.8,856.6,824.4,764.6,0.8453140333660453,-0.24244069406673358,0.013026850467129378,1.885160572014514,0.12397558602115706,0.9066638301620529,768]
["Q9NVM6","DnaJ homolog subfamily C member 17 [OS=Homo sapiens]",2,1,1,1,304,34.7,8.53,2.12,"transport;other biological processes","nucleus;other cell component","nucleic acid binding activity","DNAJC17","ENSG00000104129","","","",73.3,62.6,72.8,119.1,137.2,193.4,{"$f":"AVERAGE(S6402:U6402)/AVERAGE(V6402:X6402)","v":0.4640871692239271},{"$f":"LOG(Y6402,2)","v":-1.1075322835091808},{"$f":"TTEST(V6402:X6402,S6402:U6402,2,2)","v":0.023831273709768293},1.6228527453018382,{"$f":"AA6402*7309/AE6402","v":0.163705619872835},0.7859364113768946,1064]
["Q9NVS2","39S ribosomal protein S18a, mitochondrial [OS=Homo sapiens]",18,3,8,3,196,22.2,10.33,26.3,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPS18A","ENSG00000096080","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",814.2,770.7,794.8,728.7,660.4,655.2,1.1640659394413735,0.21917278316943226,0.01404050897035536,1.8526171486869603,0.1285990978249716,0.8907620781537167,798]
["Q9NVS9","Pyridoxine-5'-phosphate oxidase [OS=Homo sapiens]",41,7,19,7,261,30,7.06,69.9,"other metabolic processes","cytosol","other molecular function","PNPO","ENSG00000108439","Vitamin B6 metabolism; Metabolic pathways; Biosynthesis of cofactors","Vitamins B6 activation to pyridoxal phosphate","Selenium micronutrient network; Vitamin B6-dependent and responsive disorders",2597.3,2696.9,2273.7,2697.9,3014.2,4712,0.7260003261672471,-0.4619578985123913,0.2100635486838202,0.6776493020866696,0.4506470435368482,0.3461634737705741,3407]
["Q9NVX7-1","Kelch repeat and BTB domain-containing protein 4 [OS=Homo sapiens]",5,2,2,2,518,58.1,5.67,7.11,"","","","KBTBD4","ENSG00000123444; ENSG00000284900","","","",45.5,52.7,53.9,55.2,50.6,73.6,0.8478260869565216,-0.23815973719476474,0.29176159194142287,0.534971880042886,0.522668008700946,0.281774081248793,4080]
["Q9NW13-1","RNA-binding protein 28 [OS=Homo sapiens]",31,21,47,20,759,85.7,9.22,121.73,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity","RBM28","ENSG00000106344","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol","",5844,5767.7,5704.9,9041.4,8969.1,10863.1,0.5997381691233514,-0.73759530175243,0.003433511151343452,2.464261537767646,0.0681943831662209,1.1662513945571908,368]
["Q9NW82","WD repeat-containing protein 70 [OS=Homo sapiens]",26,16,25,16,654,73.2,6.33,58.75,"other biological processes","nucleus;other cell component","other molecular function","WDR70","ENSG00000082068","","","",2550.3,2675.4,2662.7,2913.7,2924.1,3248.1,0.8682023795111107,-0.20389671824891278,0.02680553306849334,1.5717755517513712,0.17322868364068772,0.7613801947928535,1131]
["Q9NWS8","Required for meiotic nuclear division protein 1 homolog [OS=Homo sapiens]",10,4,4,4,449,51.6,8.69,9.4,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","","RMND1","ENSG00000155906","","","",321.7,255.6,300.4,272,238.5,379.1,0.9866232014388489,-0.01942888072828482,0.9363384564555164,0.02856713929422456,0.9576963025795368,0.01877218927667271,7146]
["Q9NWV4","UPF0587 protein C1orf123 [OS=Homo sapiens]",71,7,29,7,160,18,5.01,88.76,"","","other molecular function","CZIB","ENSG00000162384","","","",4139.3,4076.1,3714.8,4276.2,4756,2372.8,1.0460499780797896,0.06495178218272228,0.8245257200639112,0.08379579252690866,0.8810611824484104,0.05499393236305195,6840]
["Q9NWY4","Histone PARylation factor 1 [OS=Homo sapiens]",28,10,19,10,346,39.4,6.8,59.54,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","other molecular function","HPF1","ENSG00000056050","","","",2707.1,2686.3,2866.6,2934.3,2989.8,2963.4,0.929395218002813,-0.10563587308733219,0.024112546366787842,1.6177569242284844,0.16440168040564584,0.7840937477012627,1072]
["Q9NX14-1","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [OS=Homo sapiens]",44,5,28,5,153,17.3,5.22,75.73,"cell organization and biogenesis","other membranes;mitochondrion","","NDUFB11","ENSG00000147123","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Nonalcoholic fatty liver disease",2843.9,3046.3,2959.5,2992.6,3305.4,3821.9,0.8744849257403731,-0.1934945795192207,0.1640135250801453,0.7851203371627974,0.4037638446651337,0.39387257287486904,2969]
["Q9NX20","39S ribosomal protein L16, mitochondrial [OS=Homo sapiens]",35,8,24,8,251,28.4,10.13,68.39,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL16","ENSG00000166902","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",4983,4906.2,4781.1,4468.8,4933,5423.2,0.9895649241146712,-0.015133731095566847,0.8636859750079371,0.06364413264969755,0.9073854810023015,0.042208174123374395,6957]
["Q9NX63","MICOS complex subunit MIC19 [OS=Homo sapiens]",52,16,78,16,227,26.1,8.28,211.32,"cell organization and biogenesis","other membranes;mitochondrion;nucleus","other molecular function","CHCHD3","ENSG00000106554","","Mitochondrial protein import; Cristae formation","",10196.6,8889.2,8620.8,11986.4,12012.6,9566.3,0.8254536679249106,-0.2767408548316333,0.10789959839690133,0.9669801717613363,0.3345940452621773,0.4754817924016871,2357]
["Q9NX78","Transmembrane protein 260 [OS=Homo sapiens]",4,2,4,2,707,79.5,8.4,13.94,"","other membranes","","TMEM260","ENSG00000070269","","","",201.5,198.9,238.9,156,172.6,204.9,1.1983130271790066,0.2610048227920723,0.14191391806344764,0.8479750094633264,0.37759331165844146,0.4229757069999154,2747]
["Q9NXF7","DDB1- and CUL4-associated factor 16 [OS=Homo sapiens]",7,1,2,1,216,24.2,6.04,8.54,"protein metabolism;other metabolic processes","nucleus;other cell component","","DCAF16","ENSG00000163257","","Neddylation","",167,201,168.3,229.2,232.1,187.9,0.8260936537276649,-0.2756227465243715,0.10607235677858134,0.9743977816285555,0.33202691892704544,0.47882670464671345,2335]
["Q9NXR7-1","Isoform 1 of BRISC and BRCA1-A complex member 2 [OS=Homo sapiens]",11,4,10,4,415,46.9,6.14,26.99,"","","","BABAM2","","","","",1012.3,1025.6,1033.7,1028.1,1062.9,648,1.1214311792625045,0.16534108686805635,0.4514827118755394,0.3453588749868081,0.6183037551242866,0.20879811590642264,5337]
["Q9NXX6","Non-structural maintenance of chromosomes element 4 homolog A [OS=Homo sapiens]",12,4,6,4,385,44.3,5.38,9.92,"DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","","NSMCE4A","ENSG00000107672","","SUMOylation of DNA damage response and repair proteins","",189.9,233.3,180.8,222.1,226.9,149.5,1.009189640768588,0.013197302381576861,0.9539277126312706,0.020484534305148423,0.9695810946491388,0.013415861174491735,7191]
["Q9NY35-1","Claudin domain-containing protein 1 [OS=Homo sapiens]",14,3,7,3,253,28.6,5.82,21.12,"","plasma membrane;other membranes","","CLDND1","ENSCANG00000033095; ENSG00000080822; ENSGGOG00000007565; ENSPPYG00000013614","","","",510.6,520.7,501.1,418.4,460.1,392.7,1.2054751415984897,0.269601901075361,0.013052458244131322,1.884307687458167,0.12405775982621045,0.906376065375625,769]
["Q9NYG2-1","Palmitoyltransferase ZDHHC3 [OS=Homo sapiens]",3,1,2,1,299,34.1,8.18,3.48,"protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","ZDHHC3","ENSCCAG00000029642; ENSG00000163812","","","",101.4,100.7,101,101,92.3,252.3,0.6802064631956913,-0.5559553805557025,0.4122226670381407,0.3848681311911384,0.5932143086004668,0.22678838213576305,5079]
["Q9NYH9","U3 small nucleolar RNA-associated protein 6 homolog [OS=Homo sapiens]",20,10,15,10,597,70.1,7.28,50.5,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","UTP6","ENSG00000108651","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",1167.8,1120.5,1169.9,2099.6,1986.2,1642.5,0.6037044149224028,-0.7280857431928016,0.005438448416470672,2.2645249863825865,0.08195797830099824,1.0864087631008772,485]
["Q9NYP7-1","elongation of very long chain fatty acids protein 5 [OS=Homo sapiens]",3,1,11,1,299,35.3,9.42,23.14,"other metabolic processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","ELOVL5","ENSG00000012660; ENSGGOG00000011386; ENSPPAG00000035952; ENSPTRG00000018289","Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism","Synthesis of very long-chain fatty acyl-CoAs; alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Linoleic acid metabolism affected by coronavirus infection",2222.8,2235.3,2257.7,1949,2099,783.4,1.3900318748188931,0.47511796576597265,0.2055017161403621,0.6871845469889952,0.4464958511503884,0.3501825722308968,3364]
["Q9NYU2-1","UDP-glucose:glycoprotein glucosyltransferase 1 [OS=Homo sapiens]",46,53,322,53,1555,177.1,5.63,1048.08,"protein metabolism;other metabolic processes;stress response;other biological processes","ER/Golgi;other cell component","other molecular function","UGGT1","ENSG00000136731","Protein processing in endoplasmic reticulum","ER Quality Control Compartment (ERQC)","IL-18 signaling pathway",30863.9,31350.2,31671.7,28775.3,28188.4,27790.3,1.1077447672086274,0.14762551180242384,1.191405200819004E-3,2.9239405084153973,0.043108814914782675,1.365433915978048,202]
["Q9NZ09-1","Ubiquitin-associated protein 1 [OS=Homo sapiens]",25,9,16,9,502,55,5.11,48.67,"protein metabolism;other metabolic processes;transport","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","UBAP1","ENSG00000165006","","HCMV Late Events; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy","",1171.5,1421,1212,1845.5,1822.9,1944.1,0.6778619153674834,-0.5609366774309581,0.002163599071529954,2.664823213599683,0.05415666306100148,1.2663481031641284,292]
["Q9NZB2-1","Constitutive coactivator of PPAR-gamma-like protein 1 [OS=Homo sapiens]",34,34,120,34,1118,121.8,8.88,407.71,"","plasma membrane;other membranes;cytosol;nucleus","","FAM120A","ENSG00000048828; ENSRROG00000028506","","","VEGFA-VEGFR2 signaling pathway",13922.2,14367.4,14076,14975.1,14645.7,20396.3,0.8470223183671184,-0.23952811095756854,0.24408519481583577,0.612458562265666,0.4811269387564573,0.3177403258541524,3708]
["Q9NZJ4-1","Sacsin [OS=Homo sapiens]",1,4,4,4,4579,520.8,7.05,13.72,"other biological processes","mitochondrion;nucleus;other cell component","other molecular function","SACS","ENSG00000151835","","","",216,210.8,217.9,190.3,224.6,452.3,0.7434271217712177,-0.42773677320493186,0.41815254066048396,0.3786652601335819,0.596579527559531,0.22433165412595005,5123]
["Q9NZJ7","Mitochondrial carrier homolog 1 [OS=Homo sapiens]",6,2,9,2,389,41.5,9.32,23.47,"cell organization and biogenesis;developmental processes;other biological processes","other membranes;mitochondrion","","MTCH1","ENSG00000137409","","","IL-18 signaling pathway",710.8,730.4,739,698.1,695.6,1375.5,0.7873031922576917,-0.3450087669929295,0.4347066659778028,0.3618037001009054,0.6080901476807197,0.2160320330000241,5225]
["Q9NZM4","BRD4-interacting chromatin-remodeling complex-associated protein [OS=Homo sapiens]",1,1,1,1,1560,158.4,6.65,2.78,"other biological processes","nucleus","other molecular function","BICRA","ENSG00000063169","","","",20.7,16.1,20.2,23.6,20.7,14.7,0.9661016949152542,-0.049753035197099615,0.8349461977355765,0.07834150868330433,0.8879123758546964,0.05162989070839137,6873]
["Q9NZN8-1","CCR4-NOT transcription complex subunit 2 [OS=Homo sapiens]",16,8,13,8,540,59.7,7.66,30.49,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","Cnot2; CNOT2; LOC111142051","ENSAMEG00000011938; ENSBIXG00000020780; ENSBIXG00005028198; ENSBMUG00000006457; ENSBTAG00000003748; ENSCAFG00000000441; ENSCANG00000037683; ENSCATG00000036994; ENSCCAG00000033920; ENSCSAG00000004177; ENSDLEG00000001866; ENSFCAG00000024278; ENSG00000111596; ENSGGOG00000027402; ENSLAFG00000004789; ENSLCNG00005003598; ENSMFAG00000034373; ENSMLEG00000041145; ENSMMUG00000014853; ENSMNEG00000045426; ENSMPUG00000017494; ENSPANG00000018112; ENSPCTG00005004059; ENSPPAG00000042482; ENSPTRG00000005216; ENSRBIG00000039989; ENSRFEG00010003667; ENSRROG00000042572; ENSSBOG00000026423; ENSSSUG00005015658; ENSUMAG00000020863","RNA degradation","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","",1334.6,1338.3,1551.5,1689.7,1572,1082.8,0.9723558522269535,-0.040443702568760544,0.8505023251469319,0.07032449475323249,0.8979230816840856,0.0467608644806958,6923]
["Q9P015","39S ribosomal protein L15, mitochondrial [OS=Homo sapiens]",40,10,20,10,296,33.4,10.01,72.38,"protein metabolism;other metabolic processes;other biological processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL15","ENSG00000137547","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",2357.8,2295.2,2326.4,2195.5,2298.5,2305.9,1.0263974470212798,0.03758948710071657,0.20857775412987012,0.6807320131378447,0.4495708655072901,0.34720184103195806,3391]
["Q9P0J1","[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial [OS=Homo sapiens]",7,3,6,3,537,61,6.67,16.84,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","other molecular function","PDP1","ENSG00000164951","","Regulation of pyruvate dehydrogenase (PDH) complex","Orexin receptor pathway",382.7,396,424.1,384.7,304.2,905.6,0.754343054248981,-0.4067073245656202,0.5274281249616587,0.2778367152896864,0.6719491311390559,0.17266360328815442,5737]
["Q9P0L0","vesicle-associated membrane protein-associated protein A [OS=Homo sapiens]",67,14,116,2,249,27.9,8.62,298.47,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","VAPA","ENSG00000101558","Cholesterol metabolism","Neutrophil degranulation; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; Sphingolipid de novo biosynthesis","Exercise-induced circadian regulation",17799.6,17903.7,17144.2,17705.1,19234.7,23910.2,0.8684880854560394,-0.20342203774374007,0.22923778197417458,0.6397138022777886,0.46998567978940864,0.3279153745817,3565]
["Q9P0U4","CXXC-type zinc finger protein 1 [OS=Homo sapiens]",14,8,9,8,656,75.7,8.24,25.33,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","CXXC1","ENSG00000154832","","XBP1(S) activates chaperone genes","Male infertility",452.2,460.9,436.1,486.4,491.9,510.8,0.9060506346115104,-0.1423364173954564,0.010819868584602009,1.9657780140287822,0.11411604543269277,0.9426532867566159,693]
["Q9P1Y6-1","PHD and RING finger domain-containing protein 1 [OS=Homo sapiens]",7,11,18,10,1649,178.6,8.95,39.76,"RNA metabolism OR transcription;other metabolic processes","","other molecular function","KIAA1542; PHRF1","ENSG00000070047; ENSG00000274780","","","",1491.2,1490.9,1487.5,1434.1,1541.9,1609.4,0.9747459327430542,-0.036901865088680784,0.49176172369831833,0.3082452776174817,0.6496089713556856,0.18734798594766122,5533]
["Q9P206","Uncharacterized protein KIAA1522 [OS=Homo sapiens]",2,1,2,1,1035,107,9.73,8.5,"other biological processes","","","KIAA1522","ENSG00000162522","","","",16.6,8.2,15.7,8.4,13,19.1,1,0,1,0,1.0001368363437328,-5.9423203472759478E-5,7308]
["Q9P275","Ubiquitin carboxyl-terminal hydrolase 36 [OS=Homo sapiens]",3,4,6,4,1121,122.6,9.67,13.86,"","","","","","","","",245,243.5,252.6,529.1,609.7,529.3,0.44427792098795027,-1.1704656485038287,3.3172711744781707E-4,3.4792190250841473,0.024490843448748436,1.6109962577977242,99]
["Q9P287","BRCA2 and CDKN1A-interacting protein [OS=Homo sapiens]",37,10,30,10,314,36,4.61,75.8,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus","enzyme regulator activity;cytoskeletal activity","BCCIP","ENSG00000107949","","","",3294.3,3414.2,3448.8,3395.1,3431.7,2737.9,1.061956987673424,0.08672533400750188,0.4392592300361373,0.35727910402356877,0.6100219860030643,0.21465451215687334,5263]
["Q9P2E9-1","Ribosome-binding protein 1 [OS=Homo sapiens]",74,90,756,2,1410,152.4,8.6,2319.83,"","","","","","","","",89735.5,79550.3,87724.6,98845.2,102195.2,115150.4,0.8128332639659345,-0.2989686514673345,0.02823873247710069,1.549154800911843,0.17838971104159806,0.7486301979796197,1157]
["Q9P2K5-1","Myelin expression factor 2 [OS=Homo sapiens]",8,6,16,6,600,64.1,8.75,44.33,"stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","MYEF2","ENSG00000104177","","","Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Mitochondrial gene expression",1951,1870.7,1935.5,2748.8,2154.6,2391.6,0.7891980808773132,-0.3415406470774739,0.04244990965399753,1.372123229726556,0.21456873420544118,0.668433560801095,1446]
["Q9P2M7-1","cingulin [OS=Homo sapiens]",18,23,34,23,1197,136.3,5.54,88.33,"","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity","CGN","ENSG00000143375","Tight junction","TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)","",2658.6,2357.6,2611,3284.1,3374.8,4248.9,0.6992427437246742,-0.5161347174361574,0.027236005687852508,1.564856583797458,0.17492791350836026,0.7571408839725374,1138]
["Q9P2X0-1","Dolichol-phosphate mannosyltransferase subunit 3 [OS=Homo sapiens]",24,2,11,2,92,10.1,5.94,36.9,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi;other cell component","enzyme regulator activity","DPM3","ENSG00000179085","N-Glycan biosynthesis; Metabolic pathways","Synthesis of dolichyl-phosphate mannose; Defective DPM1 causes DPM1-CDG (CDG-1e); Defective DPM3 causes DPM3-CDG (CDG-1o); Defective DPM2 causes DPM2-CDG (CDG-1u)","",1312.2,1271.6,1166.9,984.5,1168.3,1177.9,1.126099618698772,0.1713344588973174,0.14073274579423145,0.851604838861638,0.37705851869869417,0.4235912429621063,2728]
["Q9UBC2-2","Isoform 2 of Epidermal growth factor receptor substrate 15-like 1 [OS=Homo sapiens]",37,29,73,2,910,99.5,5.08,234.54,"","","","EPS15L1","","","","",6176.1,5766.7,6140.9,6578.5,7071.1,6379.2,0.9028848458220161,-0.14738609716500273,0.056430446003599415,1.2484865172270936,0.24816493973544412,0.6052595747912127,1662]
["Q9UBD5-1","Origin recognition complex subunit 3 [OS=Homo sapiens]",22,13,21,12,711,82.2,7.61,48.09,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","ORC3","ENSG00000135336","Cell cycle","CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Assembly of the ORC complex at the origin of replication; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation","Cell cycle; G1 to S cell cycle control; DNA replication",1510.6,1414.9,1485.7,1364.7,1418.2,1248.2,1.0942918806281163,0.12999759971218078,0.09346080256709514,1.0293704939198347,0.3134947250862315,0.5037697622821175,2179]
["Q9UBM7","7-dehydrocholesterol reductase [OS=Homo sapiens]",23,11,81,11,475,54.5,8.7,186.98,"other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","DHCR7","ENSG00000172893","Steroid biosynthesis; Metabolic pathways","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis via desmosterol; Cholesterol biosynthesis via lathosterol","Vitamin D metabolism; Cholesterol biosynthesis pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias",10197.9,10731.4,10447,9074,9042.4,9645.7,1.1301846762312648,0.17655853344922404,0.008454866685958577,2.0728932358496817,0.10248195789000206,0.9893525861058601,603]
["Q9UBQ7","Glyoxylate reductase/hydroxypyruvate reductase [OS=Homo sapiens]",35,10,41,10,328,35.6,7.39,118.2,"other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle;other cell component","other molecular function","GRHPR","ENSG00000137106","Glycine, serine and threonine metabolism; Pyruvate metabolism; Glyoxylate and dicarboxylate metabolism; Metabolic pathways","Glyoxylate metabolism and glycine degradation","",4105.6,4283.2,4202,4041.3,3994,4479.8,1.0060486931786403,0.008700133878302565,0.8844367382263888,0.05333322575228707,0.9204539541074578,0.03599793228460087,7023]
["Q9UBS0","Ribosomal protein S6 kinase beta-2 [OS=Homo sapiens]",20,4,6,4,482,53.4,7.34,21.13,"protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus;other cell component","kinase activity;other molecular function","RPS6KB2","ENSG00000175634","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; ErbB signaling pathway; HIF-1 signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; TGF-beta signaling pathway; Apelin signaling pathway; Fc gamma R-mediated phagocytosis; Thermogenesis; Insulin signaling pathway; Insulin resistance; Shigellosis; Human cytomegalovirus infection; Human papillomavirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Proteoglycans in cancer; Chemical carcinogenesis; Colorectal cancer; Pancreatic cancer; Acute myeloid leukemia; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer","Constitutive Signaling by AKT1 E17K in Cancer; AKT phosphorylates targets in the nucleus","IL-5 signaling pathway; AMP-activated protein kinase (AMPK) signaling; Follicle stimulating hormone (FSH) signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Thermogenesis; Translation inhibitors in chronically activated PDGFRA cells; Head and neck squamous cell carcinoma; Cytoplasmic ribosomal proteins; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; Malignant pleural mesothelioma; ErbB signaling pathway",287.4,290.4,283.2,267,302.6,319.1,0.9688308765612692,-0.04568325054877763,0.583779332084349,0.23375128468306558,0.7129228301093578,0.14695747754152214,5985]
["Q9UBU6","Protein FAM8A1 [OS=Homo sapiens]",13,2,4,2,413,44.1,7.21,15.08,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","","FAM8A1","ENSG00000137414","","","",190.8,186.6,195.2,198.5,221.7,232.1,0.8778169553886249,-0.18800795818394792,0.06035432215127793,1.219291623342332,0.25557922398823313,0.59247445283755,1726]
["Q9UBV2","Protein sel-1 homolog 1 [OS=Homo sapiens]",22,13,47,13,794,88.7,5.39,129.68,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;ER/Golgi","","SEL1L","ENSG00000071537","Protein processing in endoplasmic reticulum","ABC-family proteins mediated transport; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Defective CFTR causes cystic fibrosis; ER Quality Control Compartment (ERQC); Pre-NOTCH Processing in Golgi","Genotoxicity pathway; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5",2695.3,2560.1,2619.2,2729.8,2845.4,1926.2,1.0497507132002024,0.07004676833967988,0.6917208896430367,0.16006910863574803,0.7905845164035895,0.1020516955664478,6395]
["Q9UDW1","cytochrome b-c1 complex subunit 9 [OS=Homo sapiens]",38,2,6,2,63,7.3,9.47,16.43,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","UQCR10","ENSG00000184076","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly",895.4,900.5,908.6,809.2,859.4,551,1.2184627860875834,0.2850621893897286,0.16620682083736432,0.7793511574998884,0.40628951622083476,0.39116438394034503,2990]
["Q9UER7-1","Death domain-associated protein 6 [OS=Homo sapiens]",7,6,13,6,740,81.3,4.87,27.33,"cell organization and biogenesis;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","DAXX","ENSG00000204209; ENSG00000206206; ENSG00000206279; ENSG00000227046; ENSG00000231617","MAPK signaling pathway; Apoptosis; Parkinson disease; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Herpes simplex virus 1 infection","HCMV Early Events; Inhibition of DNA recombination at telomere; Regulation of TP53 Degradation; SUMOylation of transcription cofactors; Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations; Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations","Androgen receptor signaling pathway; Amyotrophic lateral sclerosis (ALS); Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; p38 MAPK signaling pathway",1688.2,1552.8,1593.9,2004.1,2021.9,1567.1,0.8644401137115373,-0.21016207392786992,0.17617742116548657,0.7540497513812245,0.4182139562515561,0.37860147840044966,3079]
["Q9UEW8","STE20/SPS1-related proline-alanine-rich protein kinase [OS=Homo sapiens]",22,11,31,9,545,59.4,6.29,89.07,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","STK39","ENSG00000198648","","","",2606,2632.6,2570.8,2496.9,2392,1922,1.1466032389258398,0.1973662594811423,0.13430892078542533,0.8718951405761243,0.3697415826819863,0.4321017041096393,2655]
["Q9UFW8","CGG triplet repeat-binding protein 1 [OS=Homo sapiens]",25,3,3,3,167,18.8,8.95,11.39,"cell organization and biogenesis;other biological processes","nucleus","nucleic acid binding activity;other molecular function","CGGBP1","ENSG00000163320","","","",409.9,378.2,410,383.7,354.4,353.2,1.0978649317327958,0.1347005731905081,0.07058765457558629,1.1512712482191068,0.2732654487780509,0.563415276297184,1888]
["Q9UG63","ATP-binding cassette sub-family F member 2 [OS=Homo sapiens]",38,26,112,26,623,71.2,7.37,269.11,"transport","","transporter activity;other molecular function","ABCF2","ENSG00000033050","Pathogenic Escherichia coli infection","","VEGFA-VEGFR2 signaling pathway",16243,15563.9,16044.5,17046.7,16816.5,13743.9,1.0051315875153077,0.007384385213828742,0.9437011821632528,0.025165500915584296,0.9626674027119629,0.016523733764974645,7165]
["Q9UGP4","LIM domain-containing protein 1 [OS=Homo sapiens]",34,15,32,15,676,72.1,6.65,121.56,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","LIMD1","ENSG00000144791","Hippo signaling pathway; Hippo signaling pathway","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Malignant pleural mesothelioma",2987.2,2838.3,3032.2,3581.3,3726.7,2844.1,0.8724992858620385,-0.1967741444060091,0.19743537524789095,0.7045750304985778,0.4382189971718296,0.35830879932651266,3293]
["Q9UGU5","HMG domain-containing protein 4 [OS=Homo sapiens]",7,3,3,3,601,65.7,9.32,9.13,"cell-cell signaling;transport;signal transduction;other biological processes","nucleus","nucleic acid binding activity;other molecular function","HMGXB4","ENSG00000100281","","","",156.9,152.8,160.9,167.2,147.2,135.5,1.0460102244943321,0.0648969536452515,0.5097875679126067,0.2926107597902259,0.6617008229219041,0.17933832524726173,5631]
["Q9UH17-1","DNA dC->dU-editing enzyme APOBEC-3B [OS=Homo sapiens]",21,6,14,4,382,45.9,6.06,42.85,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","other molecular function","APOBEC3B","ENSG00000179750","Human immunodeficiency virus 1 infection","Formation of the Editosome","",468.6,451.3,510.8,781.6,688.1,558.5,{"$f":"AVERAGE(S6722:U6722)/AVERAGE(V6722:X6722)","v":0.7054038063307366},{"$f":"LOG(Y6722,2)","v":-0.5034787343774335},{"$f":"TTEST(V6722:X6722,S6722:U6722,2,2)","v":0.04113446534228496},1.3857941431956227,{"$f":"AA6722*7309/AE6722","v":0.21039314708660656},0.67696841010262,1429]
["Q9UHB7-1","AF4/FMR2 family member 4 [OS=Homo sapiens]",10,9,12,9,1163,127.4,9.31,24.62,"other biological processes","nucleus;other cell component","","AFF4","ENSG00000072364","","RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex","",555.3,559.5,593.6,510.8,527.4,689.4,0.988886316276916,-0.016123418564880133,0.917796277523775,0.03725370808629518,0.945478927754936,0.02434814599581506,7095]
["Q9UHG3","prenylcysteine oxidase 1 [OS=Homo sapiens]",29,12,37,12,505,56.6,6.18,118.54,"protein metabolism;other metabolic processes;transport","non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle","other molecular function","PCYOX1","ENSG00000116005","Terpenoid backbone biosynthesis","","",3995.3,3834.5,4597.3,3712.2,3092.6,3968.9,1.1534663114807355,0.20597586880683613,0.18907130442169254,0.7233743795472267,0.43131153683462886,0.36520892507545377,3204]
["Q9UHJ6","Sedoheptulokinase [OS=Homo sapiens]",18,5,12,5,478,51.5,6.83,47.44,"other metabolic processes;other biological processes","cytosol;other cell component","kinase activity;other molecular function","SHPK","ENSG00000197417","Metabolic pathways","Pentose phosphate pathway","",778.5,778.7,862.1,811.1,678.7,3818.4,0.45576654986624465,-1.1336330503038057,0.4009225117691157,0.3969395574620796,0.58689017394762,0.2314431616332164,4993]
["Q9UHQ4","B-cell receptor-associated protein 29 [OS=Homo sapiens]",37,12,28,12,241,28.3,9.54,66.24,"transport;other biological processes","other membranes;ER/Golgi","","BCAP29","ENSG00000075790; ENSG00000283852","","","",4258.6,4451.5,4314.1,4050.9,4329.4,3711.1,1.0771457399474007,0.10721346257901104,0.1730396242997822,0.7618544364995508,0.41467102098593706,0.3822963139623637,3050]
["Q9UHW5-1","GPN-loop GTPase 3 [OS=Homo sapiens]",12,2,2,2,284,32.7,4.5,4.46,"","other cell component","other molecular function","GPN3","ENSG00000111231; ENSNLEG00000029104; ENSPPAG00000031515","","","",76.7,78.6,69.4,77.3,75.2,122.8,0.8162005085361425,-0.2930044854156538,0.3453349761004251,0.4617594333558554,0.5555917544173469,0.2552442082865085,4543]
["Q9UI09","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [OS=Homo sapiens]",6,1,3,1,145,17.1,9.63,7.87,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;mitochondrion","transporter activity","NDUFA12","ENSG00000184752","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease",420.3,425.5,410.4,572.7,488.5,5215.5,0.2001370146733156,-2.3209400813310137,0.34429029914580084,0.46307521396916274,0.5553780173155283,0.2554113142643755,4531]
["Q9UI32","Glutaminase liver isoform, mitochondrial [OS=Homo sapiens]",1,1,2,1,602,66.3,7.3,4.69,"other metabolic processes;other biological processes","mitochondrion","other molecular function","GLS2","ENSG00000135423","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; D-Amino acid metabolism; Metabolic pathways; Glutamatergic synapse; GABAergic synapse; Proximal tubule bicarbonate reclamation; MicroRNAs in cancer; Central carbon metabolism in cancer","TP53 Regulates Metabolic Genes; Glutamate and glutamine metabolism; Glutamate Neurotransmitter Release Cycle","p53 transcriptional gene network; Neuroinflammation and glutamatergic signaling",287.6,294.7,328.9,256.7,211.8,134,1.5123651452282154,0.5968065057034252,0.053821393028278666,1.2690450658315497,0.2432780220430976,0.6138971238539779,1617]
["Q9UIA9","exportin-7 [OS=Homo sapiens]",31,26,75,26,1087,123.8,6.32,238.09,"transport","nucleus;other cell component","other molecular function","XPO7","ENSG00000130227","Nucleocytoplasmic transport","","",6068.2,6361.7,6549.1,5700,6001.3,7021.5,1.013683850706091,0.01960777252193134,0.8500768398099696,0.07054181593608261,0.8977332209465493,0.04685270329286558,6921]
["Q9UII2-1","ATPase inhibitor, mitochondrial [OS=Homo sapiens]",24,4,10,4,106,12.2,9.35,31.07,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","mitochondrion;other cell component","enzyme regulator activity;other molecular function","ATP5IF1","ENSG00000130770; ENSG00000285390; ENSPPAG00000043083; ENSPPYG00000001644; ENSPTRG00000000428","","","Electron transport chain: OXPHOS system in mitochondria",838.2,815.6,938.1,680.2,661.7,675.3,1.284899861193734,0.3616559272100582,0.00730370023226616,2.1364570599732486,0.09653299276244731,1.0153242293939737,553]
["Q9UJ04","testis-specific Y-encoded-like protein 4 [OS=Homo sapiens]",2,1,2,1,414,45.1,8.57,4.23,"cell organization and biogenesis","nucleus;other cell component","other molecular function","TSPYL4","ENSG00000187189","","","",301.1,288.8,295.5,228.9,231,79.7,1.6408450704225355,0.7144390251495985,0.08334591814964952,{"$f":"-LOG10(AA6787)","v":1.079115664804085},0.29571617269698464,{"$f":"-LOG10(AC6787)","v":0.5291249232892654},2060]
["Q9UJ70","N-acetyl-D-glucosamine kinase [OS=Homo sapiens]",53,12,63,12,344,37.4,6.24,220.03,"other metabolic processes","cytosol","kinase activity;other molecular function","NAGK","ENSG00000124357","Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars","Synthesis of UDP-N-acetyl-glucosamine","",6059.1,6353.5,6009.2,6324.2,6202.2,5875.8,1.0010650900435816,1.5357823958134158E-3,0.971457858583369,0.012576034160089981,0.9801746946971072,0.008696513918137787,7244]
["Q9UJF2","ras GTPase-activating protein nGAP [OS=Homo sapiens]",6,6,7,5,1139,128.5,8.24,17.53,"signal transduction;other biological processes","cytosol","enzyme regulator activity","RASAL2","ENSG00000075391","Ras signaling pathway","Regulation of RAS by GAPs; RND1 GTPase cycle; RND3 GTPase cycle","Ras signaling",219.4,241,204.5,258.2,279.6,347.2,0.7512994350282486,-0.4125400775179095,0.06370429738718134,1.1958312698846147,0.2605566365992772,0.5840978605062862,1787]
["Q9UJQ1-1","Lysosome-associated membrane glycoprotein 5 [OS=Homo sapiens]",9,2,5,2,280,31.5,6.46,17.09,"other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","","LAMP5","ENSG00000125869","","","",404.6,429.6,435.3,462.5,462.6,243.1,1.086714603663756,0.11997310509341697,0.6708464014238673,0.17337690553914142,0.7744773887232737,0.11099125717663962,6331]
["Q9UJX4","Anaphase-promoting complex subunit 5 [OS=Homo sapiens]",17,8,16,8,755,85,6.87,43.29,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","ANAPC5","ENSG00000089053","Cell cycle; Oocyte meiosis; Ubiquitin mediated proteolysis; IL-17 signaling pathway; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection","Separation of Sister Chromatids; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Inactivation of APC/C via direct inhibition of the APC/C complex; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Cell cycle",671.3,705.1,717.8,610.4,655.3,485.9,1.195592601050468,0.257725874008181,0.09540463890995082,1.0204305078534193,0.31681622253195396,0.4991925885227942,2201]
["Q9UK23","N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [OS=Homo sapiens]",6,3,4,3,515,56,6.6,12.23,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport","other membranes;ER/Golgi","other molecular function","NAGPA","ENSG00000103174","Lysosome","","",336.1,349.9,347.4,318.8,369.4,440.7,0.9154043759411817,-0.12751890636417704,0.42190374987943247,0.37478661459273854,0.5991246372389298,0.22248282095893512,5147]
["Q9UK45","U6 snRNA-associated Sm-like protein LSm7 [OS=Homo sapiens]",54,5,11,5,103,11.6,5.27,20.11,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","LSM7","ENSG00000130332","RNA degradation; Spliceosome","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease","mRNA processing",1107,1098.9,1099.7,1203.1,1268.4,913.7,0.9764858797116864,-0.03432891244166775,0.8196875373821241,0.08635166792340698,0.8776876956820898,0.05665998998205404,6826]
["Q9UK97","F-box only protein 9 [OS=Homo sapiens]",9,3,3,3,447,52.3,6.15,9.57,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;other cell component","other molecular function","FBXO9","ENSG00000112146","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",268.4,257.4,261.9,282.5,265.3,548.2,0.7187043795620438,-0.4765296174642905,0.32480532574098514,0.48837685836879496,0.5444959004222157,0.264005385753408,4360]
["Q9UKG9-1","peroxisomal carnitine O-octanoyltransferase [OS=Homo sapiens]",8,3,3,3,612,70.1,7.08,9.46,"other metabolic processes;transport","cytosol;other cytoplasmic organelle;other cell component","other molecular function","CROT","ENSG00000005469","Peroxisome","Peroxisomal protein import; Beta-oxidation of pristanoyl-CoA","",118.6,117.8,120.8,123.8,123.7,96.6,1.038070328392909,0.05390418838424152,0.656197910424483,0.1829651569011467,0.7643267772577764,0.11672092517024946,6275]
["Q9UKK3","Poly [ADP-ribose] polymerase 4 [OS=Homo sapiens]",19,24,55,24,1724,192.5,5.66,167.84,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","PARP4","ENSG00000102699","Base excision repair; Apoptosis","Maturation of nucleoprotein; Nicotinamide salvaging; Maturation of nucleoprotein","NAD+ biosynthetic pathways; 16p11.2 proximal deletion syndrome",3801.2,3823.6,3937,4340.3,4259.5,5710.1,0.8079581268911732,-0.3076475688556225,0.12457477830482948,0.9045698770332843,0.3570655116196073,0.4472520955832665,2550]
["Q9UKM9-1","RNA-binding protein Raly [OS=Homo sapiens]",74,19,91,1,306,32.4,9.17,296.76,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","RALY","ENSG00000125970","","","",12577.7,12284,12956.8,17710.5,16283.3,9766.3,0.8642233450106374,-0.21052389233719596,0.46469722647008066,0.3328299195855472,0.628976301531448,0.2013657175245428,5400]
["Q9UKQ2-1","Disintegrin and metalloproteinase domain-containing protein 28 [OS=Homo sapiens]",9,8,14,8,775,87.1,6.95,29.09,"protein metabolism;other biological processes","non-structural extracellular;plasma membrane;other membranes;mitochondrion","other molecular function","ADAM28","ENSG00000042980","","","",1471.2,1532,1557.8,1444.9,1472.7,1416.4,1.0523765574526995,0.07365101676408102,0.06745537629198489,1.170983430708275,0.2685355911318723,0.5709981456895257,1836]
["Q9UKV5","E3 ubiquitin-protein ligase AMFR [OS=Homo sapiens]",20,6,8,6,643,72.9,6.39,27.33,"cell-cell signaling;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","AMFR","ENSG00000159461","Protein processing in endoplasmic reticulum","ER Quality Control Compartment (ERQC); N-glycan trimming in the ER and Calnexin/Calreticulin cycle","Sterol regulatory element-binding proteins (SREBP) signaling",449.5,442,465.5,377.8,432.2,465,1.064313725490196,0.08992347367263372,0.35827512779857723,0.4457833404098474,0.5642389375306617,0.24853694694490447,4641]
["Q9UL15-1","BAG family molecular chaperone regulator 5 [OS=Homo sapiens]",25,8,17,8,447,51.2,6.05,44.99,"cell organization and biogenesis;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","BAG5","ENSG00000166170","","Regulation of HSF1-mediated heat shock response","",992.4,916.5,972.3,932.6,886.5,876.3,1.0689322549528828,0.0961704231795315,0.09592996748682113,1.0180457027237777,0.3174070313993552,0.49838345671123974,2209]
["Q9UL26","Ras-related protein Rab-22A [OS=Homo sapiens]",26,4,7,4,194,21.8,8.15,16.74,"cell organization and biogenesis;transport","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","RAB22A","ENSG00000124209","Endocytosis","RAB geranylgeranylation","",985.5,1062.3,1105.7,716.9,816.9,261.7,1.7563352826510723,0.8125682802064847,0.06036034730341499,1.2192482700309284,0.25530889956056724,0.5929340462898299,1728]
["Q9ULC3","Ras-related protein Rab-23 [OS=Homo sapiens]",27,6,13,6,237,26.6,6.6,31.71,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","RAB23","ENSG00000112210","","RAB geranylgeranylation","Genes related to primary cilium development (based on CRISPR); Ciliopathies",1440.1,1483.7,1525,1206.6,1309.9,1080.4,1.2368428368873197,0.30666219162530794,0.015942753669998932,1.7974366640942403,0.13581070696272984,0.8670659900589727,858]
["Q9ULH1-1","Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 [OS=Homo sapiens]",14,14,26,14,1129,125.4,7.31,81.99,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","ASAP1","ENSG00000153317","Endocytosis; Fc gamma R-mediated phagocytosis","VxPx cargo-targeting to cilium","EGF/EGFR signaling pathway; CCL18 signaling pathway",2017.1,1951.7,2009.6,1860.9,1884.6,1952.6,1.0491918358751162,0.06927848664966693,0.05313118623555976,1.2746504876888558,0.24165266969241211,0.6168084025682274,1607]
["Q9ULJ3","Zinc finger and BTB domain-containing protein 21 [OS=Homo sapiens]",2,3,4,3,1066,118.8,8.29,9.48,"other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","ZBTB21","ENSG00000173276","","","",435.7,446.2,454.5,592.5,636.5,524.7,0.7620459599703484,-0.39205008375438943,0.013486540989269434,1.8700994233378496,0.12653803349238804,0.8977789191264411,779]
["Q9ULN7-5","Isoform 2 of Paraneoplastic antigen-like protein 8B [OS=Homo sapiens]",2,1,1,1,635,68.6,5.45,0,"","","","PNMA8B","ENSG00000204851","","","",33.6,28.7,32,38.5,34.3,36.4,0.8635531135531136,-0.2116431802447558,0.05784479793382392,1.2377356916857765,0.2516593024394756,0.5991870115276664,1680]
["Q9ULQ1-1","Two pore calcium channel protein 1 [OS=Homo sapiens]",3,2,2,2,816,94.1,8.27,6.27,"transport;signal transduction;other biological processes","other membranes;other cytoplasmic organelle","transporter activity;other molecular function","TPCN1","ENSG00000186815; ENSGGOG00000010443","Calcium signaling pathway","Stimuli-sensing channels","",119.3,111.8,116.5,95.7,92.7,85.3,1.2700036536353672,0.34483264744944375,2.8813260908741953E-3,2.5404075881433474,0.06139828687521719,1.2118437463021448,343]
["Q9ULU8-3","Isoform 3 of Calcium-dependent secretion activator 1 [OS=Homo sapiens]",4,3,5,1,1314,148.7,5.81,6.79,"","","","CADPS","","","","",40.1,34.1,43,40.1,37.4,55.4,0.8818660647103085,-0.18136853485392668,0.4452571471414425,0.3513891006369193,0.6135717361343896,0.21213465414966312,5304]
["Q9ULZ3","apoptosis-associated speck-like protein containing a CARD [OS=Homo sapiens]",47,9,36,9,195,21.6,6.34,109.68,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function","PYCARD","ENSG00000103490","Necroptosis; NOD-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Legionellosis; Yersinia infection; Influenza A; Lipid and atherosclerosis","Neutrophil degranulation; The AIM2 inflammasome; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; CLEC7A/inflammasome pathway","Nucleotide-binding oligomerization domain (NOD) pathway; Nanomaterial-induced inflammasome activation; TYROBP causal network in microglia; Acute viral myocarditis; Cytosolic DNA-sensing pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Prostaglandin signaling",3687.6,3530.4,3478.6,3538.5,3974.9,3412.1,0.9790490137751132,-0.030547008132703873,0.6961100488701327,0.15732209682770773,0.7943588364077752,0.09998326902443988,6405]
["Q9UM13","Anaphase-promoting complex subunit 10 [OS=Homo sapiens]",11,2,3,2,185,21.2,9.06,7.44,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","","ANAPC10","ENSG00000164162","Cell cycle; Oocyte meiosis; Ubiquitin mediated proteolysis; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection","Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; Senescence-Associated Secretory Phenotype (SASP); APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Cell cycle",251.6,249,279.2,285.7,268.4,187.7,1.0512267457535724,0.07207388689462625,0.7099457631856694,0.14877482825120336,0.8034985418278193,0.09501490704837326,6458]
["Q9UMS4","Pre-mRNA-processing factor 19 [OS=Homo sapiens]",51,15,72,15,504,55.1,6.61,239.65,"cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","PRPF19","ENSG00000110107","Spliceosome; Ubiquitin mediated proteolysis","mRNA Splicing - Major Pathway; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of TC-NER Pre-Incision Complex","",8646.3,8792.2,8874.7,9516.5,9443,6134,1.0486062127642617,0.0684729986472779,0.734396848114782,0.13406919570835968,0.820499321747316,0.08592177361334959,6542]
["Q9UNA1-1","Rho GTPase-activating protein 26 [OS=Homo sapiens]",6,4,5,4,814,92.2,6.64,11.44,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","ARHGAP26","ENSG00000145819","","RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOB GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOD GTPase cycle; RHOQ GTPase cycle","",497.3,519,526.5,482.9,418.3,989.1,0.8161667460191503,-0.29306416440725763,0.5563437216445678,0.2546568086141894,0.6928465260692019,0.15936295624378985,5869]
["Q9UNF1","Melanoma-associated antigen D2 [OS=Homo sapiens]",41,19,58,18,606,64.9,9.32,192.7,"transport;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","","MAGED2","ENSG00000102316","","Platelet degranulation","",6749,6657.2,6775,8736.3,8331.5,8860,0.7783614498723378,-0.3614878357642754,3.0391087085403088E-4,3.5172537649826414,0.02524186994400127,1.5978784752488369,88]
["Q9UNM6","26S proteasome non-ATPase regulatory subunit 13 [OS=Homo sapiens]",61,21,115,21,376,42.9,5.81,329.62,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","PSMD13","ENSG00000185627","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection","Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease",17420.6,17497.5,18076.5,16496.8,15674.4,9014.6,1.286720180256302,0.3636983484703433,0.1732023334611695,0.7614462612650748,0.4147889434035675,0.3821728286639447,3052]
["Q9UNS1","Protein timeless homolog [OS=Homo sapiens]",7,6,12,6,1208,138.6,5.4,27.19,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity","TIMELESS","ENSG00000111602","","Processing of DNA double-strand break ends","",402.7,403.3,408.4,524.2,513.7,737.1,0.6841690140845071,-0.5475753287513025,0.062190886435477905,1.2062732529421771,0.2576832136943923,0.588913871854005,1764]
["Q9UNZ2","NSFL1 cofactor p47 [OS=Homo sapiens]",61,22,122,1,370,40.5,5.1,384.24,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","NSFL1C","ENSG00000088833","Protein processing in endoplasmic reticulum","RHOH GTPase cycle","",14025.7,14164.4,14161.4,14706.7,15005.6,17377.1,0.8993849995965121,-0.1529892726862956,0.13532404273412998,0.8686250363725411,0.3707209251663254,0.4309528997330795,2668]
["Q9UPN9-2","Isoform Beta of E3 ubiquitin-protein ligase TRIM33 [OS=Homo sapiens]",7,7,8,1,1110,120.5,6.67,20.82,"","","","TRIM33","","","","",62.5,61.3,63.5,81.2,86.9,63.8,0.8076757222940922,-0.30815192040295825,0.10010651100497547,0.9995376747527213,0.32389486008648327,0.48959594378911125,2259]
["Q9UPQ3-1","Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 [OS=Homo sapiens]",4,3,8,2,857,94.4,7.94,10.84,"transport","nucleus;other cell component","enzyme regulator activity;other molecular function","AGAP1","ENSG00000157985","Endocytosis","","",213.7,215.2,225.4,184.4,181.9,233.8,1.090318280286619,0.12474934084038707,0.35514194091316176,0.44959803614229904,0.5626994246985257,0.24972352886659277,4613]
["Q9UPT6","C-Jun-amino-terminal kinase-interacting protein 3 [OS=Homo sapiens]",4,7,12,4,1336,147.4,5.4,32.57,"cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","MAPK8IP3","ENSG00000138834","MAPK signaling pathway","","MAPK signaling pathway",784,737,785,244,246.7,379.3,2.650574712643678,1.4063052069156812,5.402623170181484E-4,3.267395323191526,0.030610676551051524,1.514127071606802,129]
["Q9UPY8","Microtubule-associated protein RP/EB family member 3 [OS=Homo sapiens]",19,5,11,1,281,32,5.54,26.85,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MAPRE3","ENSG00000084764","","","",21.7,22.1,25.6,22.4,24.6,13,1.1566666666666667,0.20997316208238015,0.4522666379676906,0.3446054473655601,0.6191453187686553,0.20820740633949597,5339]
["Q9UPY8-2","Isoform 2 of Microtubule-associated protein RP/EB family member 3 [OS=Homo sapiens]",19,5,11,1,266,30.4,5.3,28.17,"","","","MAPRE3","","","","",188.9,180.7,216.3,194.9,218.3,448.5,0.6799350121852153,-0.5565312339341134,0.32305928793016714,0.4907177685107181,0.5433134688176695,0.2649495286112508,4346]
["Q9UQ90","Paraplegin [OS=Homo sapiens]",11,7,10,7,795,88.2,8.69,29.27,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes","other membranes;mitochondrion;other cell component","other molecular function","SPG7","ENSG00000197912","","Processing of SMDT1","",762.6,760.3,780.6,704.2,703.1,870,1.0115048522372985,0.016503240590113138,0.8832553254222907,0.053913735388115676,0.9196172611839776,0.03639288563394799,7020]
["Q9UQL6-1","histone deacetylase 5 [OS=Homo sapiens]",5,4,6,4,1122,121.9,6.24,18.79,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","HDAC5","ENSG00000108840","Apelin signaling pathway; Neutrophil extracellular trap formation; Alcoholism; Viral carcinogenesis; MicroRNAs in cancer","Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Regulation of PTEN gene transcription","MicroRNAs in cardiomyocyte hypertrophy; Cell differentiation - expanded index; Cell differentiation - index; Neural crest differentiation; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; VEGFA-VEGFR2 signaling pathway; Ethanol effects on histone modifications; Rett syndrome causing genes",250.3,246.6,235.3,279.3,268.1,372,0.7963889493147706,-0.3284548925122583,0.13364737004262164,0.8740395830145524,0.3688929862694568,0.43309960189824176,2648]
["Q9Y222-1","Cyclin-D-binding Myb-like transcription factor 1 [OS=Homo sapiens]",3,2,2,2,760,84.4,4.61,4.62,"cell cycle OR cell proliferation;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","DMTF1","ENSG00000135164","","","",92.5,91.2,83.6,97.5,83.5,79.9,1.024530471444998,0.0349628934256261,0.7418986248721529,0.12965543389409,0.8253481048996294,0.08336284156989783,6570]
["Q9Y248","Dna replication complex gins protein psf2 [OS=Homo sapiens]",16,3,4,3,185,21.4,5.44,9.5,"DNA metabolism;other metabolic processes;stress response","nucleus","","GINS2","ENSG00000131153","","Unwinding of DNA","",343.6,332.1,344.7,346.6,381.8,455,0.8622612810545885,-0.21380299614754159,0.16660245484950797,0.7783186036510763,0.40698440591412227,0.3904222309595271,2992]
["Q9Y259-1","Choline/ethanolamine kinase [OS=Homo sapiens]",8,3,3,3,395,45.2,5.49,5.95,"other metabolic processes","cytosol","kinase activity;other molecular function","CHKB","ENSG00000100288","Glycerophospholipid metabolism; Metabolic pathways; Choline metabolism in cancer","Synthesis of PC; Synthesis of PE","Fatty acid beta-oxidation; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids",170,207,198.9,180.1,175.5,597.2,0.6044290512174643,-0.7263550911680037,0.4210247399322142,0.37569238373592423,0.5984577643260508,0.2229664941587931,5142]
["Q9Y281-1","Cofilin-2 [OS=Homo sapiens]",33,5,42,1,166,18.7,7.88,107.36,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity","CFL2; CFL2b; LOC101358143; LOC111160529","ENSAMEG00000015508; ENSANAG00000001737; ENSBIXG00000015466; ENSBIXG00005004635; ENSBTAG00000015053; ENSCAFG00000032562; ENSCANG00000033619; ENSCCAG00000037328; ENSCHIG00000015758; ENSCJAG00000041665; ENSCPOG00000033162; ENSECAG00000000511; ENSFCAG00000008480; ENSG00000165410; ENSGGOG00000038032; ENSHGLG00000001467; ENSLCNG00005006126; ENSMFAG00000001352; ENSMLEG00000005793; ENSMMNG00015019505; ENSMMUG00000039560; ENSMNEG00000039241; ENSMPUG00000016306; ENSNLEG00000003417; ENSPANG00000021779; ENSPCOG00000013026; ENSPCTG00005008413; ENSPPAG00000007558; ENSPPYG00000005737; ENSPTRG00000006254; ENSRROG00000036826; ENSSBOG00000014011; ENSSSCG00000001959; ENSSSCG00015060726; ENSSSCG00025071059; ENSSSCG00030060165; ENSSSCG00035044355; ENSSSCG00040010975; ENSSSCG00045008975; ENSSSCG00050005802; ENSSSCG00055017925; ENSSSCG00060075576; ENSSSCG00065063654; ENSSSCG00070007061; ENSSSUG00005010833; ENSVVUG00000019333","Axon guidance; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Pertussis; Human immunodeficiency virus 1 infection","","Actin cytoskeleton regulation; G13 signaling pathway; G13 signaling pathway; Leptin signaling pathway; Microtubule cytoskeleton regulation; Microtubule cytoskeleton regulation; Leptin signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; G13 signaling pathway",62.2,59.9,70.5,63.6,55.9,53,1.1165217391304347,0.15901134129056552,0.21181526245510135,0.6740427497940733,0.4529425843429888,0.34395684629481843,3418]
["Q9Y2C4","Nuclease EXOG, mitochondrial [OS=Homo sapiens]",7,3,6,3,368,41.1,8.27,11.83,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes","other membranes;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","EXOG","ENSG00000157036","","","",724.2,784.6,777.7,743.2,738,671.8,1.062006502554575,0.0867925996397299,0.21058896473574543,0.6765643904152019,0.4511121756311733,0.34571545102671436,3412]
["Q9Y2D4","Exocyst complex component 6B [OS=Homo sapiens]",9,7,9,6,811,94.1,6.46,28.88,"cell organization and biogenesis;transport","other membranes;other cell component","","EXOC6B","ENSG00000144036","","","Ciliary landscape",565.1,567,577.3,602.3,531.1,718.3,0.9231516984392719,-0.11536035427173959,0.4346633097922698,0.3618470173367745,0.6082623264927628,0.21590908128979514,5223]
["Q9Y2H0-1","Isoform 2 of Disks large-associated protein 4 [OS=Homo sapiens]",3,2,2,2,989,107.5,7.3,6.2,"","","","DLGAP4","","","","",125.4,113.2,137.2,168.6,167.9,195.8,0.7059928611685141,-0.5022744995054302,0.010544976021769131,1.9769544034660018,0.11186245245734482,0.9513156634896547,689]
["Q9Y2H6","Fibronectin type-III domain-containing protein 3a [OS=Homo sapiens]",11,9,18,9,1198,131.8,6.71,49.03,"cell adhesion;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","","FNDC3A","ENSG00000102531","","","",1381.9,1381.9,1418.5,1463.7,1450.1,825.3,{"$f":"AVERAGE(S7042:U7042)/AVERAGE(V7042:X7042)","v":1.1185311973469552},{"$f":"LOG(Y7042,2)","v":0.16160549567290544},{"$f":"TTEST(V7042:X7042,S7042:U7042,2,2)","v":0.5222679613163033},0.2821066152702518,{"$f":"AA7042*7309/AE7042","v":0.6700467841426823},0.1738948728429588,5697]
["Q9Y2K7","Lysine-specific demethylase 2A [OS=Homo sapiens]",18,21,32,21,1162,132.7,7.58,78.47,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus","nucleic acid binding activity;other molecular function","KDM2A","ENSG00000173120","","HDMs demethylate histones","",3043.8,2978,3071.1,3333.4,3320.5,2496.9,0.9936726843554663,-0.009157388394254283,0.94799965206214,0.02319182205805229,0.9655698797271712,0.015216290210115021,7176]
["Q9Y2R0","Cytochrome c oxidase assembly factor 3 homolog, mitochondrial [OS=Homo sapiens]",27,3,7,3,106,11.7,9.6,19.06,"cell organization and biogenesis;other biological processes","other membranes;mitochondrion","","COA3","ENSG00000183978","Thermogenesis","","Mitochondrial complex IV assembly",581.5,441.9,402.8,604.4,982.6,283.6,0.7624291671121566,-0.3913247835576953,0.5179007415035595,0.28575346718123,0.6674901286632897,0.17555515258325577,5671]
["Q9Y2R9","28S ribosomal protein S7, mitochondrial [OS=Homo sapiens]",15,3,10,3,242,28.1,9.99,35.8,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPS7","ENSG00000125445","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1386.3,1099.9,1059.8,1572,1982.6,1426.1,0.711948119742205,-0.4901559802654517,0.07098325461813063,1.14884409191023,0.27421596617543165,0.5619072620920311,1892]
["Q9Y2S0-1","DNA-directed RNA polymerases I and III subunit RPAC2 [OS=Homo sapiens]",24,3,7,3,133,15.2,5.8,19.33,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","POLR1D","ENSG00000186184; ENSGGOG00000004235; ENSNLEG00000000358; ENSPTRG00000005734","RNA polymerase; Cytosolic DNA-sensing pathway","","Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway",520.6,513.6,454.5,604.5,638.3,889.7,0.6981008206330598,-0.5184926875018017,0.08085641185511967,1.0922855351529466,0.29256411596488596,0.5337789427155974,2020]
["Q9Y2S7","Polymerase delta-interacting protein 2 [OS=Homo sapiens]",41,12,33,12,368,42,8.63,108.07,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component","nucleic acid binding activity","POLDIP2","ENSG00000004142","","","",3113.5,3140.4,3245.4,3231,2999.9,5148.5,0.8347803926393307,-0.26053138007984955,0.4102300777276946,0.386972500690507,0.593032365132856,0.22692160408086265,5056]
["Q9Y2T2","ap-3 complex subunit mu-1 [OS=Homo sapiens]",30,8,16,7,418,46.9,6.93,58.53,"transport","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","AP3M1","ENSG00000185009","Lysosome","Association of TriC/CCT with target proteins during biosynthesis","",1442.8,1470.6,1507.1,1369.3,1354.9,1120.2,1.1498543335761109,0.20145110852781423,0.08135202176921177,1.089631649459739,0.2929073532567334,0.5332697254889789,2030]
["Q9Y2U5","Mitogen-activated protein kinase kinase kinase 2 [OS=Homo sapiens]",8,4,5,2,619,69.7,8,15.49,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus","kinase activity;other molecular function","MAP3K2","ENSG00000169967","MAPK signaling pathway; Gap junction; GnRH signaling pathway","","IL-1 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; MAPK cascade; EGF/EGFR signaling pathway; Insulin signaling; Malignant pleural mesothelioma",202.7,172.3,198.8,230.2,191.5,185.3,0.9453047775947281,-0.08114854837438017,0.5502622588694872,0.25943027335422725,0.687616148072676,0.16265393283357657,5849]
["Q9Y2U8","inner nuclear membrane protein Man1 [OS=Homo sapiens]",29,20,56,20,911,99.9,7.55,184,"cell organization and biogenesis;other biological processes","other membranes;nucleus","nucleic acid binding activity","LEMD3","ENSG00000174106","","RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOG GTPase cycle; RND2 GTPase cycle; RHOD GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; Initiation of Nuclear Envelope (NE) Reformation; Depolymerisation of the Nuclear Lamina","Envelope proteins and their potential roles in EDMD physiopathology",5163.9,5179.6,5175.3,5421.7,5449.2,6775,0.8794564176380915,-0.1853160096464235,0.1875734496786573,0.7268286343688637,0.43031209783468494,0.3662164439500034,3186]
["Q9Y2V2","Calcium-regulated heat-stable protein 1 [OS=Homo sapiens]",29,4,22,4,147,15.9,8.21,91.27,"signal transduction;other biological processes","cytosol;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","CARHSP1","ENSG00000153048","","","",3087.4,3132,3050.4,2641.4,2660.6,2835.7,1.1391179325853742,0.18791711662325075,0.004671266467926306,2.330565358092391,0.07621046119212806,1.1179854102065618,448]
["Q9Y2V7-1","Conserved oligomeric Golgi complex subunit 6 [OS=Homo sapiens]",7,5,6,5,657,73.2,5.76,14.61,"other metabolic processes;transport","other membranes;ER/Golgi","","COG6","ENSG00000133103","","Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network; COPI-mediated anterograde transport","",327.4,322.1,346.8,313.5,311.1,765.2,0.7168657360771332,-0.48022515731870513,0.43448319450614703,0.3620270170850389,0.6082431849541139,0.21592274841178155,5221]
["Q9Y2W1","Thyroid hormone receptor-associated protein 3 [OS=Homo sapiens]",38,42,191,41,955,108.6,10.15,496.99,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","THRAP3","ENSG00000054118","","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","Interactome of polycomb repressive complex 2 (PRC2)",29731.9,28244.7,28402.3,26341.1,28273.6,22863.1,1.1148858124520833,0.15689595566565576,0.14686991845605993,0.8330671462542838,0.38351991210980424,0.41621208283647326,2799]
["Q9Y2W2","WW domain-binding protein 11 [OS=Homo sapiens]",17,12,38,12,641,70,8.38,88.86,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","WBP11","ENSG00000084463","Spliceosome","mRNA Splicing - Major Pathway","",4600.1,4539.7,4696.8,6116.1,6297.7,6088.9,0.7478151837299422,-0.4192463307392849,4.1117594047411318E-5,4.385972305552245,0.013660386131478604,1.864537024490478,22]
["Q9Y2W6","tudor and KH domain-containing protein [OS=Homo sapiens]",27,12,19,12,561,62,5.02,53.9,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","mitochondrion;other cell component","nucleic acid binding activity","TDRKH","ENSG00000182134","","PIWI-interacting RNA (piRNA) biogenesis","",1965.2,2028.8,1977.2,2171.1,2042.3,2490.2,0.8907452711975654,-0.16691517551046672,0.14380891916874386,0.8422141777525409,0.37959530162670596,0.4206791716141424,2769]
["Q9Y2X0-1","Mediator of RNA polymerase II transcription subunit 16 [OS=Homo sapiens]",7,7,8,7,877,96.7,7.37,15.28,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","MED16","ENSG00000175221","Thyroid hormone signaling pathway","Transcriptional regulation of white adipocyte differentiation; Generic Transcription Pathway; PPARA activates gene expression","",745.1,808.3,789.9,807.2,817.6,1086.3,0.8643355095717604,-0.21033666208363083,0.25893900163504585,0.5868025307964985,0.49531147944269827,0.30512160660093435,3821]
["Q9Y2X3","Nucleolar protein 58 [OS=Homo sapiens]",52,27,199,27,529,59.5,8.92,613.24,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NOP58","ENSG00000055044","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; SUMOylation of RNA binding proteins; rRNA modification in the nucleus and cytosol","",27873.8,27442.6,27240.5,24997,25124,15352.5,1.2609208305650377,0.3344776960175861,0.1538102830295439,0.8130146286847726,0.39170709361077916,0.407038563534792,2870]
["Q9Y2X7-1","ARF GTPase-activating protein GIT1 [OS=Homo sapiens]",27,17,25,15,761,84.3,6.8,70.26,"developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","GIT1","ENSG00000108262","Endocytosis; Regulation of actin cytoskeleton; Epithelial cell signaling in Helicobacter pylori infection","RHOJ GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOU GTPase cycle; CDC42 GTPase cycle; RHOQ GTPase cycle; RHOV GTPase cycle; Ephrin signaling; Activation of RAC1 downstream of NMDARs","CAMKK2 pathway; Regulation of actin cytoskeleton",2175.7,2137.7,2096.7,2088.4,2070.2,1963.3,1.047076887894281,0.06636738468609377,0.10073186863614662,0.9968331095531601,0.32462488000952194,0.488618197890056,2268]
["Q9Y2X9","Zinc finger protein 281 [OS=Homo sapiens]",1,1,2,1,895,96.9,8.48,4.27,"developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF281","ENSG00000162702","","","Mesodermal commitment pathway",61.6,78.6,72.4,95.8,122.9,102.6,0.6616868969810147,-0.5957793839403073,0.0191093462185462,1.718754171057743,0.14779916562048062,0.8303280176830329,945]
["Q9Y2Y0","ADP-ribosylation factor-like protein 2-binding protein [OS=Homo sapiens]",34,5,13,5,163,18.8,4.35,30.82,"signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","ARL2BP","ENSG00000102931","","Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane","Ciliopathies",1259.5,1298.8,1254.3,1387.7,1358.9,869.9,1.0542236969445595,0.07618102658642208,0.717970899002104,0.14389315834674185,0.8098224229639472,0.09161020233336223,6480]
["Q9Y2Y9","Krueppel-like factor 13 [OS=Homo sapiens]",9,2,2,1,288,31.2,9.54,6.01,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KLF13","ENSG00000169926; ENSG00000275746","","","15q13.3 copy number variation syndrome",68.3,87.2,73.1,195,197.1,225.9,0.3699029126213592,-1.434781434577259,3.4745200566459867E-4,3.4591051770150276,0.024418526051947612,1.612280554429835,104]
["Q9Y2Z0-1","Protein SGT1 homolog [OS=Homo sapiens]",46,14,43,14,365,41,5.16,124.5,"cell cycle OR cell proliferation;other biological processes","cytosol;nucleus;other cell component","other molecular function","SUGT1","ENSG00000165416; ENSPTRG00000005906","NOD-like receptor signaling pathway","The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection","Nucleotide-binding oligomerization domain (NOD) pathway",5461.9,5507.2,5445.6,5475.8,5403.5,4255.8,1.084545196265634,0.117090175711566,0.3416257507875805,0.4664494008534871,0.5540143360342636,0.25647899704049154,4507]
["Q9Y2Z2-6","Isoform 7 of Protein MTO1 homolog, mitochondrial [OS=Homo sapiens]",10,6,7,6,732,81.5,8.16,15.6,"","","","MTO1","","","","",249.5,266.2,239.2,304.9,309.6,282.4,0.8416768870554132,-0.24866159426507545,0.014678042137995359,1.8333318698539542,0.13131188492852885,0.8816959645023967,817]
["Q9Y2Z4","Tyrosine--tRNA ligase, mitochondrial [OS=Homo sapiens]",27,10,15,10,477,53.2,8.98,35.42,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;mitochondrion;nucleus","nucleic acid binding activity;other molecular function","YARS2","ENSG00000139131","Aminoacyl-tRNA biosynthesis","Mitochondrial tRNA aminoacylation","Orexin receptor pathway",1366.2,1369.5,1370.5,1303.9,1286.9,1083,1.117698296042245,0.1605308093395282,0.11214013609004635,0.9502389211899025,0.3391114003649767,0.46965760971357995,2417]
["Q9Y2Z9-1","Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial [OS=Homo sapiens]",6,3,4,3,468,50.8,7.3,4.76,"other metabolic processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","COQ6","ENSG00000119723","Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways; Biosynthesis of cofactors","Ubiquinol biosynthesis","Nephrotic syndrome",357.5,395.3,410,336.2,279.4,198.9,1.4276243093922654,0.5136163727233574,0.05336046529358431,1.272780392105842,0.24224325517441472,0.6157483062537189,1610]
["Q9Y303","N-acetylglucosamine-6-phosphate deacetylase [OS=Homo sapiens]",22,7,18,1,409,43.7,6.7,58.49,"other metabolic processes","cytosol","other molecular function","AMDHD2","ENSG00000162066","Amino sugar and nucleotide sugar metabolism; Metabolic pathways","Synthesis of UDP-N-acetyl-glucosamine","",101.2,121,106.8,116.2,133.1,132.4,0.8619334555933978,-0.21435160259295452,0.0952169620973784,1.021285678830756,0.31676867363210687,0.49925777386729325,2197]
["Q9Y303-3","Isoform 3 of N-acetylglucosamine-6-phosphate deacetylase [OS=Homo sapiens]",19,8,18,2,594,63.6,7.53,56.95,"","","","AMDHD2","","","","",1498.6,1501.3,1535,1541.1,1527.1,2130.1,0.8723813554431257,-0.1969691578949172,0.32887420962433367,0.48297018263471797,0.5460567010777498,0.26276225896807415,4402]
["Q9Y305-1","Acyl-coenzyme A thioesterase 9, mitochondrial [OS=Homo sapiens]",34,14,39,14,439,49.9,8.6,116.05,"other metabolic processes","mitochondrion","other molecular function","ACOT9","ENSG00000123130","","Mitochondrial Fatty Acid Beta-Oxidation","VEGFA-VEGFR2 signaling pathway",2881.8,3027.4,2932.1,2837.9,2676.8,3382.1,0.9937618019962233,-0.009028005937277726,0.9363346870333897,0.028568887639081497,0.9578264839086138,0.018713158882097566,7145]
["Q9Y312","Protein AAR2 homolog [OS=Homo sapiens]",24,6,14,6,384,43.4,5.96,36.75,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","","AAR2","ENSG00000131043","","","Ciliary landscape",1115.7,1203.8,1187.3,1128.1,1185.6,1205,0.9966180691732743,-4.8873638617440195E-3,0.9165463543120975,0.037845565712266785,0.9445907083568981,0.024756330757173997,7092]
["Q9Y314","nitric oxide synthase-interacting protein [OS=Homo sapiens]",45,8,17,8,301,33.2,8.82,55.24,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","NOSIP","ENSG00000142546","","NOSIP mediated eNOS trafficking","",1190.1,1196,1194.7,1297,1334,865.9,1.0239926792301752,0.03420540120112053,0.8614046628276888,0.06479278170871651,0.9059002418140399,0.04291962441485742,6950]
["Q9Y315","deoxyribose-phosphate aldolase [OS=Homo sapiens]",31,10,21,10,318,35.2,8.94,65.5,"other metabolic processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","DERA","ENSG00000023697","Pentose phosphate pathway; Metabolic pathways","Neutrophil degranulation; Pentose phosphate pathway","",2783,2805.3,2867.3,2670.1,2677.3,2588.8,1.0654469393412465,0.0914587467992908,0.010334390022608327,1.9857151520926348,0.11026869587626899,0.9575477617010874,685]
["Q9Y316-1","Protein MEMO1 [OS=Homo sapiens]",39,9,21,9,297,33.7,7.14,62.18,"other biological processes","","other molecular function","LOC111154137; LOC114499315; MEMO1","ENSANAG00000021250; ENSCANG00000020056; ENSCATG00000030724; ENSCCAG00000037443; ENSCHIG00000006439; ENSCJAG00000003208; ENSDLEG00000015222; ENSECAG00000019946; ENSFCAG00000001385; ENSG00000162959; ENSHGLG00000018935; ENSMMUG00000003908; ENSMNEG00000040106; ENSMODG00000047380; ENSPANG00000022798; ENSPCOG00000018130; ENSPCTG00005009736; ENSPTRG00000050445; ENSRFEG00010015180; ENSSSCG00000008515; ENSSSCG00070008027; ENSVURG00010020209; ENSVVUG00000007616","","ERBB2 Regulates Cell Motility; ERBB2 Regulates Cell Motility","",2142,2328.6,2138.3,2141.8,2131.2,1889.4,1.0724555368038426,0.10091783591846239,0.22431997222675412,0.6491320574837999,0.4661798911018896,0.3314464639167696,3517]
["Q9Y320","Thioredoxin-related transmembrane protein 2 [OS=Homo sapiens]",40,11,38,11,296,34,8.69,125.59,"developmental processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","TMX2","ENSG00000213593","","","",5259.8,5439.1,5338.9,4534.8,4799.9,4497.3,1.1594707923655292,0.21346647825029222,2.470320583985964E-3,2.6072466828449476,0.05731927983604257,1.2416992747505753,315]
["Q9Y333","U6 snRNA-associated Sm-like protein LSm2 [OS=Homo sapiens]",75,6,22,6,95,10.8,6.52,72.61,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LSM2","ENSG00000172850; ENSG00000204392; ENSG00000224979; ENSG00000225998; ENSG00000231502; ENSG00000236826","RNA degradation; Spliceosome","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease; mRNA Splicing - Minor Pathway","mRNA processing",2280.9,2289,2362.8,2644.8,2300,1727.3,1.0390581675934114,0.05527642012239283,0.762788644777513,0.11759578068525209,0.839389070261795,0.07603669006364555,6642]
["Q9Y365","START domain-containing protein 10 [OS=Homo sapiens]",12,2,4,2,291,33,7.12,6.11,"transport","other membranes;cytosol;cytoskeleton;other cell component","other molecular function","STARD10","ENSG00000214530","","Synthesis of PC","",13.4,14,17.3,17,12,3.9,1.358662613981763,0.4421872474480764,0.3816222653824876,0.41836629473665127,0.5757021955997114,0.2398021142394625,4845]
["Q9Y371","Endophilin-B1 [OS=Homo sapiens]",28,12,35,11,365,40.8,6.04,97.7,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SH3GLB1","ENSG00000097033","Autophagy; Endocytosis","","Nanoparticle triggered autophagic cell death; Senescence and autophagy in cancer",3586.5,3659.2,3521.6,3687.5,3427,1953.7,1.1873690478816081,0.24776841079987733,0.35443086833264964,0.45046846126935913,0.5623041494776072,0.2500287116380658,4607]
["Q9Y375","Complex I intermediate-associated protein 30, mitochondrial [OS=Homo sapiens]",36,11,26,11,327,37.7,7.64,91.39,"cell organization and biogenesis;other metabolic processes","other membranes;cytosol;mitochondrion","other molecular function","NDUFAF1","ENSG00000137806","Thermogenesis","Complex I biogenesis","Mitochondrial immune response to SARS-CoV-2",2780.3,2752.5,2725.4,2697.6,2847.7,3446.4,0.918424769509659,-0.12276654350217031,0.3463265606412513,0.4605142000543777,0.5563298531267924,0.2546676348275172,4550]
["Q9Y376","Calcium-binding protein 39 [OS=Homo sapiens]",45,16,38,16,341,39.8,6.89,98.08,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","CAB39","ENSG00000135932","mTOR signaling pathway; AMPK signaling pathway","Neutrophil degranulation; Energy dependent regulation of mTOR by LKB1-AMPK","AMP-activated protein kinase (AMPK) signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias",6247.7,6625.7,6274.4,6320.1,6471.8,6590.3,0.9879064296106735,-0.017553692682132818,0.6179610473695211,0.20903889941868053,0.738381117414391,0.13171941803250994,6117]
["Q9Y383","Putative RNA-binding protein Luc7-like 2 [OS=Homo sapiens]",40,20,182,14,392,46.5,10.01,519.86,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","LUC7L2","ENSG00000146963","","","",20256.4,19842.8,20144.1,20480.8,21202.6,18635.2,0.9987516288508023,-1.8021439725966913E-3,0.9756947345981559,0.010686038702921515,0.9829569697006095,0.007465493592703199,7255]
["Q9Y385","ubiquitin-conjugating enzyme e2 j1 [OS=Homo sapiens]",33,9,26,9,318,35.2,6.74,93.82,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","UBE2J1","ENSG00000198833","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum; Parkinson disease; Pathways of neurodegeneration","Antigen processing: Ubiquitination & Proteasome degradation","Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway",1719.7,1783.5,1771.3,2608.3,2758.8,3543.6,0.5919288046954785,-0.75650443134652,0.014023331227501308,1.8531488079190648,0.1287644823389536,0.8902039137727608,796]
["Q9Y388","RNA-binding motif protein, X-linked 2 [OS=Homo sapiens]",15,5,9,5,322,37.3,9.83,24.14,"RNA metabolism OR transcription;other metabolic processes","nucleus","","RBMX2","ENSG00000134597","","","",1301,1289.5,1384.3,1429.7,1465.7,1287.6,0.950227109729859,-0.07365572784087052,0.32589028640302237,0.48692858407132755,0.5454389977833045,0.26325381410869464,4367]
["Q9Y394","Dehydrogenase/reductase SDR family member 7 [OS=Homo sapiens]",40,9,16,9,339,38.3,8.32,51.28,"","","other molecular function","DHRS7","ENSG00000100612","","","",1610.9,1741,1771.6,1497.4,1495,1290.3,1.1963247484063793,0.2586090695690986,0.029453455539031868,1.530863745579893,0.18151374918615845,0.7410904727241638,1186]
["Q9Y399","28S ribosomal protein S2, mitochondrial [OS=Homo sapiens]",12,5,13,5,296,33.2,9.26,31.26,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPS2","ENSG00000122140","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",2001.5,2007.7,2075.2,1887.4,1788.1,1304.1,1.2218652100570326,0.28908514316986056,0.112649078221112,0.948272357647407,0.34008761367951573,0.46840918520516694,2421]
["Q9Y3A0-1","Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial [OS=Homo sapiens]",15,4,6,4,265,29.6,9.17,14.49,"other metabolic processes","other membranes;mitochondrion;other cell component","","COQ4","ENSG00000167113","","","",187.8,182,165.8,188.1,200.5,285.5,0.7945408693072243,-0.33180666457675306,0.21436205984701015,0.6688520783876534,0.45558950143117105,0.3414262923256939,3439]
["Q9Y3A3","MOB-like protein phocein [OS=Homo sapiens]",46,7,22,7,225,26,5.78,49.1,"","other membranes;ER/Golgi;other cell component","other molecular function","MOB4","ENSG00000115540","","","",948.9,876.1,918.9,1157.1,1134.6,928.1,0.8521957885582956,-0.23074317296648345,0.1047394312883842,0.9798897885497427,0.3301166465229841,0.4813325753037571,2319]
["Q9Y3A4","Ribosomal RNA-processing protein 7 homolog A [OS=Homo sapiens]",21,5,9,5,280,32.3,9.58,22.92,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","","RRP7A","ENSG00000189306","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",916,835.1,841,2353.5,2293.2,1679.8,0.4097210147791037,-1.2872862036799,0.004558651545755387,2.341163603134566,0.07572541851801393,1.1207583177367804,440]
["Q9Y3A5","Ribosome maturation protein SBDS [OS=Homo sapiens]",54,17,52,17,250,28.7,8.75,132.39,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;translation activity;nucleic acid binding activity","SBDS","ENSG00000126524","Ribosome biogenesis in eukaryotes","","",6964.5,6229.6,6267,7376.6,6836.8,6523.9,0.9384587193125429,-0.09163480934417455,0.28525484191615236,0.5447669751319385,0.5174801785964651,0.28610628063634325,4029]
["Q9Y3A6-1","Transmembrane emp24 domain-containing protein 5 [OS=Homo sapiens]",36,7,15,7,229,26,4.84,29.15,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED5","ENSG00000117500","","WNT ligand biogenesis and trafficking","",2206.3,2212.6,2274.8,1839.6,1838.2,1107.8,1.3987169842861917,0.48410407781919695,0.060082062367454565,1.2212551682237183,0.2556110557879659,0.5924203658349688,1718]
["Q9Y3B2","Exosome complex component csl4 [OS=Homo sapiens]",28,4,6,4,195,21.4,8.24,17.07,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","EXOSC1","ENSG00000171311","RNA degradation","Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease","",671.9,669.6,744.7,739.7,595.9,337.1,1.2472051174747416,0.3186987527604945,0.31594141661300174,0.500393438901815,0.5392844030883769,0.26818213997626145,4282]
["Q9Y3B3-1","Transmembrane emp24 domain-containing protein 7 [OS=Homo sapiens]",33,6,21,6,224,25.2,6.89,52.45,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED7","ENSG00000134970; ENSPTRG00000017152","","COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic","Regulation of toll-like receptor signaling pathway",2349.2,2497,2946.4,2413.6,1963.2,2249.3,{"$f":"AVERAGE(S7106:U7106)/AVERAGE(V7106:X7106)","v":1.1760462413787898},{"$f":"LOG(Y7106,2)","v":0.2339447871269187},{"$f":"TTEST(V7106:X7106,S7106:U7106,2,2)","v":0.15564429661430818},0.8078667888543595,{"$f":"AA7106*7309/AE7106","v":0.3933624356687339},0.4052071155928797,2892]
["Q9Y3B4","Splicing factor 3B subunit 6 [OS=Homo sapiens]",11,1,1,1,125,14.6,9.38,2.98,"RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus","nucleic acid binding activity","SF3B6","ENSG00000115128","Spliceosome","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","",42.9,44.3,40,52.7,55.7,129.9,0.5337809483843894,-0.9056802809059158,0.21680213518214758,{"$f":"-LOG10(AA7107)","v":0.663936444950725},0.4581112477728583,{"$f":"-LOG10(AC7107)","v":0.33902904508111353},3459]
["Q9Y3B6","ER membrane protein complex subunit 9 [OS=Homo sapiens]",8,1,3,1,208,23,5.91,12.27,"cell organization and biogenesis","other membranes;ER/Golgi;other cell component","","EMC9","ENSG00000100908; ENSG00000285377","","","",109,92.1,99.8,91.2,105.2,167.6,0.8266483516483517,-0.2746543437527217,0.43005674453008774,0.36647423695439385,0.6048267742486841,0.21836899189328035,5197]
["Q9Y3B7-1","39S ribosomal protein L11, mitochondrial [OS=Homo sapiens]",58,12,42,12,192,20.7,9.91,125.25,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL11","ENSG00000174547; ENSPPAG00000028194; ENSPTRG00000003924","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",6337.9,6308.4,5568.1,5465.8,6521.3,4421.4,1.110058810982113,0.15063611266963642,0.41100680365489684,0.38615098891390137,0.5932165734426621,0.22678672403922712,5064]
["Q9Y3B8-1","Oligoribonuclease, mitochondrial [OS=Homo sapiens]",32,6,20,6,237,26.8,6.87,64.33,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","REXO2","ENSG00000076043; ENSPPAG00000039849; ENSPTRG00000004306","Ribosome biogenesis in eukaryotes","","",1556.8,1397.9,1323.8,2298.5,2291.8,2560.6,0.598316295850872,-0.7410197378562577,1.0298343548957502E-3,2.987232624362753,0.03982571058165629,1.3998364666520242,189]
["Q9Y3B9","RRP15-like protein [OS=Homo sapiens]",16,5,12,5,282,31.5,5.52,20.14,"RNA metabolism OR transcription;other metabolic processes","other cell component","","RRP15","ENSG00000067533","","","",1865.9,1823.8,1643.9,2733.3,2804.3,1870,0.7200172795507317,-0.47389656496711724,0.08811523596274377,1.0549489914466228,0.3040766098449926,0.517016985334116,2118]
["Q9Y3C0","WASH complex subunit 3 [OS=Homo sapiens]",17,2,3,2,194,21.2,4.46,8.94,"cell organization and biogenesis;transport","other cytoplasmic organelle;other cell component","","WASHC3","ENSG00000120860","Endocytosis","","",331.1,317.6,317.4,473,479.8,205,0.8344273622387287,-0.2611416279226805,0.5195361811483944,0.2843842022435931,0.6685369626784533,0.17487457607063903,5680]
["Q9Y3C1","nucleolar protein 16 [OS=Homo sapiens]",14,3,4,3,178,21.2,9.94,6.24,"other biological processes","nucleus;other cell component","","NOP16","ENSG00000048162","","","",361.5,318.2,407.5,533.5,442.7,562.8,0.7064327485380117,-0.5013758704481812,0.027491727910864613,1.5607979630095525,0.175797934646115,0.7549862315208614,1143]
["Q9Y3C4","EKC/KEOPS complex subunit TPRKB [OS=Homo sapiens]",25,3,10,3,175,19.6,6.79,31.28,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","TPRKB","ENSG00000144034","","tRNA modification in the nucleus and cytosol","",967.6,1030.8,932,1014.4,967.4,741.5,1.076047442441156,0.10574168706341003,0.48148649676292793,0.3174158881107456,0.6420698421529356,0.19241772829897288,5481]
["Q9Y3C6","Peptidyl-prolyl cis-trans isomerase-like 1 [OS=Homo sapiens]",34,5,30,5,166,18.2,7.99,62.77,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","PPIL1","ENSG00000137168","Spliceosome","mRNA Splicing - Major Pathway","",4274.3,4160.3,4167.6,4385.9,4618.2,5330.9,0.8791210324380887,-0.18586629370775598,0.11417595983308955,0.9424253287600493,0.3425747497619259,0.465244650836914,2436]
["Q9Y3C8","ubiquitin-fold modifier-conjugating enzyme 1 [OS=Homo sapiens]",38,8,27,8,167,19.4,7.4,79.1,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes","","other molecular function","UFC1","ENSG00000143222","","","",4599.5,4310.4,3738.4,5314.4,5642.1,4971.8,0.7940772084905482,-0.33264880679987885,0.026476865960388837,1.5771334231848224,0.17186448783701777,0.7648138518161769,1126]
["Q9Y3D0","Mitotic spindle-associated MMXD complex subunit MIP18 [OS=Homo sapiens]",13,1,2,1,163,17.7,5.19,7.54,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","","CIAO2B","ENSG00000166595","","Cytosolic iron-sulfur cluster assembly","",38.2,49.2,52.7,66.6,68,98.4,0.6012875536480687,-0.7338729991108244,0.051324739275227314,1.2896732481262487,0.23727547081760686,0.6247471561744848,1581]
["Q9Y3D2","Methionine-R-sulfoxide reductase B2, mitochondrial [OS=Homo sapiens]",16,1,1,1,182,19.5,8.63,5.54,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response","cytosol;mitochondrion;other cell component","cytoskeletal activity;other molecular function","MSRB2","ENSG00000148450","","Protein repair","Sulindac metabolic pathway; Methionine de novo and salvage pathway",75.2,71.7,71.6,61.5,71.3,129.9,0.8317472401979442,-0.2657829207456715,0.5287799579035523,0.27672501406864536,0.6722652134835734,0.17245936083064728,5749]
["Q9Y3D3","28S ribosomal protein S16, mitochondrial [OS=Homo sapiens]",34,4,10,4,137,15.3,9.5,31.7,"protein metabolism;other metabolic processes","other membranes;cytosol;mitochondrion;translational apparatus","other molecular function","MRPS16","ENSG00000182180","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",951.2,920.8,915.3,1015.8,1111.7,910.5,0.9174786043449639,-0.12425358027247024,0.2306863075723217,0.6369781823417596,0.47018578417348,0.3277305056839507,3586]
["Q9Y3D6","mitochondrial fission 1 protein [OS=Homo sapiens]",20,3,14,3,152,16.9,8.79,36.07,"cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","FIS1","ENSG00000214253","Mitophagy","Class I peroxisomal membrane protein import","CAMKK2 pathway",1030.6,1017.3,1033,810,942.1,613.5,1.3023757186337501,0.3811457075014827,0.06716991578463027,1.172825196204706,0.26842258855651324,0.5711809397971499,1829]
["Q9Y3D8","Adenylate kinase isoenzyme 6 [OS=Homo sapiens]",47,5,11,5,172,20,4.58,41.12,"other metabolic processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","AK6","ENSG00000085231; ENSG00000279247","Purine metabolism; Metabolic pathways; Biosynthesis of cofactors; Ribosome biogenesis in eukaryotes","Interconversion of nucleotide di- and triphosphates","",803.5,770.5,836.7,1085.3,917.8,1281.6,0.733917861600755,-0.4463094858954011,0.052632541668075156,1.2787456570439621,0.2401318645767549,0.619550206908208,1602]
["Q9Y3D9","28S ribosomal protein S23, mitochondrial [OS=Homo sapiens]",19,4,5,4,190,21.8,8.9,13.39,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus","other molecular function","MRPS23","ENSG00000181610","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",904,912.6,830,989.6,990.3,417.1,1.104130162703379,0.1429102572768782,0.6882328687314492,0.16226459011697297,0.788323779589118,0.1032953728553914,6381]
["Q9Y3E0","vesicle transport protein GOT1B [OS=Homo sapiens]",25,4,27,4,138,15.4,10.36,67.71,"transport","other membranes;ER/Golgi;other cell component","","GOLT1B","ENSG00000111711","","","",1936.5,2147.2,2189.4,1868.5,1967.7,2015.4,1.0720315811060221,0.10034740694674002,0.19110308600470108,0.7187322997372873,0.43216969542337874,0.3643456899558629,3232]
["Q9Y3E1","Hepatoma-derived growth factor-related protein 3 [OS=Homo sapiens]",18,3,6,2,203,22.6,7.99,12.72,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;nucleus","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function","HDGFL3","ENSG00000166503","","","",193.9,195.7,194,165.9,180.7,340.5,0.8493669043807306,-0.2355401997834141,0.5705183390692672,0.24373039081005057,0.7025979006330706,0.15329315221668763,5935]
["Q9Y3E2","BolA-like protein 1 [OS=Homo sapiens]",9,1,1,1,137,14.3,7.96,2.23,"","mitochondrion","","BOLA1","ENSG00000178096","","","",60.4,48.9,64.6,39.9,54.3,19,1.5362190812720848,0.619383974474705,0.1470632998057792,0.8324956935569662,0.3834768670283411,0.4162608294332794,2803]
["Q9Y3E5","Peptidyl-tRNA hydrolase 2, mitochondrial [OS=Homo sapiens]",56,7,11,7,179,19.2,8.73,36.93,"other biological processes","cytosol;mitochondrion","other molecular function","PTRH2","ENSG00000141378","","Ub-specific processing proteases","",1154.5,1186.3,1092.8,1101,1162.5,819.9,1.113575922682753,0.15519992323021092,0.3443873679005754,0.4629527868109719,0.5552894930477179,0.2554805439856868,4533]
["Q9Y3E7","Charged multivesicular body protein 3 [OS=Homo sapiens]",9,2,2,2,222,25.1,5.12,5.28,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","CHMP3","ENSG00000115561","Endocytosis; Necroptosis","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","",86.6,92.1,84.3,73,85.2,107,0.9917043740573154,-0.012017975932922849,0.9461900085618569,0.024021642262260227,0.963995368354978,0.015925052718235026,7174]
["Q9Y3F4","Serine-threonine kinase receptor-associated protein [OS=Homo sapiens]",63,16,105,16,350,38.4,5.12,381.28,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","STRAP","ENSG00000023734","","Downregulation of TGF-beta receptor signaling","TGF-beta signaling pathway; Epithelial to mesenchymal transition in colorectal cancer",10706.6,11002.8,10450.3,11101.9,10678.4,10899.1,0.9840970152450779,-0.02312754709344622,0.4375579603770848,0.35896441074523694,0.6090480160723887,0.21534846714832093,5251]
["Q9Y3I0","tRNA-splicing ligase RtcB homolog [OS=Homo sapiens]",68,26,142,26,505,55.2,7.23,472.97,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","cytoskeletal activity;other molecular function","RTCB","ENSG00000100220","","tRNA processing in the nucleus","Unfolded protein response",16901.4,16521.2,17017.7,17112.9,16675.2,13862.5,1.0585449081438638,0.08208247613068513,0.4174116899851646,0.3794353922974973,0.5963373811770071,0.22450796622014063,5116]
["Q9Y3I1","F-box only protein 7 [OS=Homo sapiens]",5,2,4,2,522,58.5,6.55,8.54,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","FBXO7","ENSG00000100225","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",478.3,448.6,434.6,552.5,524.8,452.7,0.8898692810457516,-0.16833467053621817,0.15817834416355078,0.8008529750358819,0.3959333964011619,0.4023778646003272,2920]
["Q9Y3L3-1","SH3 domain-binding protein 1 [OS=Homo sapiens]",18,12,33,12,701,75.7,6.77,85.44,"cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","SH3BP1","ENSG00000100092","","RAC1 GTPase cycle","",3292.6,3443.1,3264.4,3053.2,3248.6,2645.7,1.1176417993853032,0.16045788312397746,0.1323896978004517,0.8781458091749839,0.36778270666039586,0.4344086953767139,2631]
["Q9Y3L5","ras-related protein Rap-2c [OS=Homo sapiens]",46,8,43,4,183,20.7,4.94,126.77,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","RAP2C","ENSG00000123728","Tight junction","Neutrophil degranulation","",1417.8,1344.3,1343.9,1119.4,1273.1,966,1.222569599523597,0.2899165985348485,0.053618459875281105,1.270685664752113,0.24296176269586459,0.6144620702571015,1613]
["Q9Y3M8-4","Isoform 4 of StAR-related lipid transfer protein 13 [OS=Homo sapiens]",1,1,3,1,1078,120.6,6.95,6.05,"","","","STARD13","","","","",357.1,303.3,369.4,369.8,438,248.1,0.9752817501657356,-0.036109034130685516,0.8901488234054742,0.05053737787139701,0.9248184435352681,0.03394351775818854,7035]
["Q9Y3P4","rhomboid domain-containing protein 3 [OS=Homo sapiens]",3,1,3,1,386,40.5,6.58,7.94,"protein metabolism;developmental processes;signal transduction;other biological processes","other membranes","other molecular function","RHBDD3","ENSG00000100263","","","",103.9,100.3,100.6,97.9,100.5,223.6,0.7222748815165876,-0.46938009610122566,0.39970922151599125,0.39825583220696464,0.5861706862079414,0.23197590397410486,4984]
["Q9Y3P9","Rab GTPase-activating protein 1 [OS=Homo sapiens]",31,26,56,23,1069,121.7,5.25,167.69,"cell cycle OR cell proliferation;transport;other biological processes","cytosol;cytoskeleton","enzyme regulator activity;cytoskeletal activity;other molecular function","RABGAP1","ENSG00000011454","","TBC/RABGAPs","",6110.8,5890.7,5803.8,5691.8,6178.7,5403.9,1.0307333395081737,0.04367114208633065,0.508230686448049,0.29393911623819796,0.6606185465496692,0.1800492378636279,5623]
["Q9Y3Q3","Transmembrane emp24 domain-containing protein 3 [OS=Homo sapiens]",12,3,7,3,217,24.8,5.6,19.5,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED3","ENSG00000166557","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport","",924.8,935.2,1043.6,867.8,797,536,1.3193384223918574,0.39981467655461916,0.09548409391527642,1.020068968732125,0.31693607739634666,0.49902832148388493,2202]
["Q9Y3Q8","TSC22 domain family protein 4 [OS=Homo sapiens]",32,8,19,6,395,41,7.21,54.61,"stress response;other biological processes","nucleus","","TSC22D4","ENSG00000166925","","","",1663.7,1594.8,1575.5,1834.1,1933.2,1824.7,0.8644492131616595,-0.2101468876098539,4.4937413626490365E-3,2.347391927022965,0.07550518533241794,1.1220232220936297,435]
["Q9Y3R5-1","Protein dopey-2 [OS=Homo sapiens]",3,5,5,5,2298,258.1,6.29,14.93,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","","DOP1B","ENSG00000142197","","","",544.3,526.3,571.5,543.6,547.4,430.1,1.0795476957464993,0.11042698481188577,0.3773973953895849,0.42320110144674766,0.5732330762473973,0.24166875823058187,4812]
["Q9Y3S2","zinc finger protein 330 [OS=Homo sapiens]",27,8,24,8,320,36.2,6.16,60.9,"","nucleus;other cell component","other molecular function","ZNF330","ENSG00000109445","","","",2232,2432.4,2157,2946.2,2560.4,4084.6,0.7112144465760278,-0.4916434656129378,0.117969880200531,0.9282288616129531,0.34711829886702134,0.4595224912335228,2484]
["Q9Y3T6","R3H and coiled-coil domain-containing protein 1 [OS=Homo sapiens]",21,7,9,7,440,49.1,5.63,30.34,"","","nucleic acid binding activity","R3HCC1","ENSG00000104679","","","",1148.7,1165.9,1189.6,1403.8,1450.8,1583.1,0.7896432836829891,-0.34072702271801736,0.004801019961633587,2.318666488321754,0.07628403239039107,1.1175663581193551,460]
["Q9Y3T9","Nucleolar complex protein 2 homolog [OS=Homo sapiens]",24,16,48,16,749,84.9,5.62,133.65,"cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","other molecular function","NOC2L","ENSG00000188976","","Regulation of TP53 Activity through Phosphorylation","",5183.9,5122.6,5470.2,5637.9,5219.9,4016.2,1.060689794271884,0.0850027922554003,0.5781322043742685,0.2379728379376568,0.708156239613127,0.1498709138977818,5967]
["Q9Y3U8","60S ribosomal protein L36 [OS=Homo sapiens]",21,2,5,2,105,12.2,11.59,14.47,"protein metabolism;other metabolic processes","cytosol;translational apparatus;nucleus","other molecular function","RPL36","ENSG00000130255","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",457.8,383.6,398.1,417.6,415.4,464.6,0.9552250308261406,-0.06608745324318835,0.5244359321990801,0.2803075598859001,0.6712963622492254,0.17308570624777517,5710]
["Q9Y3X0","coiled-coil domain-containing protein 9 [OS=Homo sapiens]",17,9,13,9,531,59.7,5.4,33.02,"","","","CCDC9","ENSG00000105321","","","IL-18 signaling pathway",2818.9,2731,2660.4,3671.6,3065.9,1727.5,0.9699113998818665,-0.044075129844405314,0.8899832859600201,0.05061814940395695,0.9247779125791564,0.033962551500907795,7034]
["Q9Y3Z3","deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [OS=Homo sapiens]",60,33,158,33,626,72.2,7.14,474.84,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","plasma membrane;other membranes;nucleus;other cell component","nucleic acid binding activity;other molecular function","SAMHD1","ENSG00000101347","Human immunodeficiency virus 1 infection","Interferon alpha/beta signaling; Nucleotide catabolism","",20894.8,20193.5,20442.7,18719.7,18668.2,15829.7,1.1562152370644296,0.2094099900019747,0.0469955606428848,1.327943165029337,0.22762793422057323,0.6427744429209539,1509]
["Q9Y448","Small kinetochore-associated protein [OS=Homo sapiens]",3,1,1,1,316,35.4,6.3,0,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KNSTRN","ENSG00000128944","","","Overview of leukocyte-intrinsic Hippo pathway functions",139.4,127.5,156,182.9,219.5,132.7,0.7903195664361803,-0.33949196857256053,0.23072535270372616,0.6369046814460758,0.4698722772113498,0.3280201778953427,3589]
["Q9Y450-1","HBS1-like protein [OS=Homo sapiens]",41,23,81,23,684,75.4,6.61,246.97,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol","nucleic acid binding activity;other molecular function","HBS1L","ENSG00000112339","mRNA surveillance pathway; Legionellosis","mRNA decay by 3' to 5' exoribonuclease","",7978.5,7942,8193.3,8128.4,7925.3,7937.2,1.0051227757191268,0.007371737327188954,0.7094289435325447,0.149091097002997,0.8031623525835454,0.09519665683303805,6456]
["Q9Y478","5'-AMP-activated protein kinase subunit beta-1 [OS=Homo sapiens]",24,4,7,4,270,30.4,6.4,23.12,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","PRKAB1","ENSG00000111725","FoxO signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Apelin signaling pathway; Tight junction; Circadian rhythm; Thermogenesis; Insulin signaling pathway; Adipocytokine signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Insulin resistance; Non-alcoholic fatty liver disease; Alcoholic liver disease; Hypertrophic cardiomyopathy","Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Lipophagy","AMP-activated protein kinase (AMPK) signaling; Target of rapamycin (TOR) signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Angiopoietin-like protein 8 regulatory pathway; Leptin and adiponectin; Lipid metabolism pathway; Genotoxicity pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; Malignant pleural mesothelioma",267.2,254.5,305.2,284,271.2,528.7,0.7628932558354092,-0.3904468858618948,0.3713277755010839,0.43024256411698175,0.5693380975744541,0.24462975416005073,4767]
["Q9Y483","Metal-response element-binding transcription factor 2 [OS=Homo sapiens]",8,3,3,3,593,67.1,8.72,9.82,"","","","","","","","",216.6,246.7,237.2,283,283.3,305.6,0.8034178231448561,-0.3157776281797603,7.937867442342544E-3,2.1002961578274255,0.0991758515146695,1.003594062025633,585]
["Q9Y484-1","WD repeat domain phosphoinositide-interacting protein 4 [OS=Homo sapiens]",3,1,3,1,360,39.8,7.14,9.19,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response","other membranes;cytosol;other cell component","other molecular function","WDR45","ENSCANG00000035794; ENSCSAG00000012964; ENSG00000196998; ENSGGOG00000000589; ENSMFAG00000032970; ENSMLEG00000042347; ENSMMUG00000010620","","Macroautophagy","Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway",357.9,354.9,353.1,393.7,394.5,803.6,0.6696192989068979,-0.5785869868974736,0.26841259285833546,0.5711971126439087,0.5044555518646372,0.29717709390739544,3889]
["Q9Y485","DmX-like protein 1 [OS=Homo sapiens]",10,21,31,21,3027,337.6,6.34,93.99,"other biological processes","other cell component","","DMXL1","ENSG00000172869","","","",1770.8,1743,1906.5,2034.3,1931.5,1955.9,0.915328368542817,-0.12763870047075554,0.047830999526944036,1.3202905435582954,0.22954482964046877,0.639132485010365,1523]
["Q9Y487","V-type proton ATPase 116 kDa subunit a isoform 2 [OS=Homo sapiens]",11,8,18,7,856,98,6.61,37.74,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ATP6V0A2","ENSG00000185344","Oxidative phosphorylation; Metabolic pathways; Lysosome; Phagosome; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Tuberculosis; Human papillomavirus infection; Rheumatoid arthritis","ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","",766.5,777.9,823.2,784.2,770.8,1132,0.8811313732787498,-0.18257095945581314,0.4232804103914975,0.37337183040560556,0.5999140041790684,0.22191099992834742,5157]
["Q9Y490","Talin-1 [OS=Homo sapiens]",70,136,676,115,2541,269.6,6.07,2295.38,"cell adhesion;cell organization and biogenesis;signal transduction","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","TLN1","ENSG00000137076","Rap1 signaling pathway; Focal adhesion; Platelet activation; Shigellosis; Human T-cell leukemia virus 1 infection","Platelet degranulation ; p130Cas linkage to MAPK signaling for integrins; Signaling by BRAF and RAF1 fusions; XBP1(S) activates chaperone genes; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Smooth Muscle Contraction; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins","Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion",75074.5,74773.1,74130.3,73253.2,73499.4,77350.4,0.999441774541171,-8.0557396802448551E-4,0.9769320784881823,0.010135629692882932,0.9839322807868437,0.007034790890452079,7257]
["Q9Y496","kinesin-like protein KIF3A [OS=Homo sapiens]",11,7,14,7,699,80,6.54,27.19,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF3A","ENSG00000131437","Hedgehog signaling pathway","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Hedgehog 'off' state; Activation of SMO","Hedgehog signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Insulin signaling",1026.9,881.5,980.1,878.7,984.9,1451.3,0.871368668738122,-0.19864485479100272,0.4762116509207479,0.3221999834193967,0.6378286524793378,0.1952959753185697,5457]
["Q9Y4A5","Transformation/transcription domain-associated protein [OS=Homo sapiens]",9,29,55,29,3859,437.3,8.19,157.22,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","ER/Golgi;nucleus","other molecular function","TRRAP","ENSG00000196367","Human T-cell leukemia virus 1 infection","Ub-specific processing proteases; HATs acetylate histones; Formation of the beta-catenin:TCF transactivating complex","Rett syndrome causing genes",3310.2,3323.9,3414.3,4027.6,3916.3,5737.7,0.7344462635949014,-0.44527115629257785,0.1095171610363514,0.9605178227468506,0.3364694955925567,0.47305430290014394,2379]
["Q9Y4B4","Helicase ARIP4 [OS=Homo sapiens]",5,5,5,5,1467,162.7,6.09,13.39,"cell organization and biogenesis","nucleus","nucleic acid binding activity;other molecular function","RAD54L2","ENSG00000164080","","","",177.5,176.4,176.3,213.9,197.5,1260.7,0.31708629866634774,-1.6570525551093482,0.34001568753628375,0.46850104515400365,0.5529983667562746,0.2572761513531408,4494]
["Q9Y4B5","Microtubule cross-linking factor 1 [OS=Homo sapiens]",11,17,21,15,1905,209.4,6.43,59.89,"cell organization and biogenesis;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MTCL1","ENSG00000168502","","","",1649.6,1444.1,1623.1,1862.9,1685.3,2081,0.8379165778440986,-0.2551214771220679,0.08158040113344986,1.0884141635737725,0.293440527502158,0.5324799053016811,2032]
["Q9Y4B6","DDB1- and CUL4-associated factor 1 [OS=Homo sapiens]",14,17,24,17,1507,168.9,5.06,59.02,"protein metabolism;DNA metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","kinase activity;other molecular function","DCAF1","ENSG00000145041","Human immunodeficiency virus 1 infection","Antigen processing: Ubiquitination & Proteasome degradation","Hippo-Merlin signaling dysregulation",1832.2,1761,1850.1,2579.6,2545.3,2725.4,0.6933875138529738,-0.5282662373840894,1.9993507084318008E-4,3.6991110190997896,0.022481929735273895,1.648166413858672,65]
["Q9Y4C1","Lysine-specific demethylase 3A [OS=Homo sapiens]",4,4,5,4,1321,147.2,8.07,17.37,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KDM3A","ENSG00000115548","Thermogenesis","NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; HDMs demethylate histones","Thermogenesis; Male infertility; Vitamin D-sensitive calcium signaling in depression",280.9,315.3,322.4,360.8,345.1,322.8,0.8929717118693495,-0.16331362143584677,0.09570271715254917,1.0190757317361474,0.31708574780960197,0.4988232779563462,2206]
["Q9Y4C2-1","TRPM8 channel-associated factor 1 [OS=Homo sapiens]",12,8,10,8,921,102.1,6.54,20.97,"other biological processes","plasma membrane;other membranes","other molecular function","TCAF1","ENSG00000198420","","","",691.6,676,689.5,703.6,754.2,665.7,0.9687308688485988,-0.04583218064774365,0.4441436850883919,0.3524765083850588,0.6129618946961964,0.21256652293272935,5296]
["Q9Y4C8","Probable RNA-binding protein 19 [OS=Homo sapiens]",6,5,6,5,960,107.3,6.54,18.91,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","RBM19","ENSG00000122965","","","",272.8,276.1,300.1,429.6,476.6,568.1,0.5758665129213865,-0.7961936642353529,0.007412515783002858,2.130034368910817,0.09691963838634685,1.0135882149132678,559]
["Q9Y4D1","Disheveled-associated activator of morphogenesis 1 [OS=Homo sapiens]",8,9,12,9,1078,123.4,7.23,24.91,"cell-cell signaling;cell organization and biogenesis;signal transduction","plasma membrane;other membranes;cytosol;cytoskeleton","cytoskeletal activity;other molecular function","DAAM1","ENSG00000100592","Wnt signaling pathway","RHO GTPases Activate Formins; RHOA GTPase cycle; PCP/CE pathway; RHOC GTPase cycle; CDC42 GTPase cycle; RHOB GTPase cycle","Physico-chemical features and toxicity-associated pathways; Wnt signaling; Genotoxicity pathway",1288.7,1432.4,1487.2,1127.9,1187.2,1162.8,1.21001178872308,0.27502110324323864,0.016818167935729874,1.7742213152407378,0.14016418408466322,0.8533629467228052,877]
["Q9Y4D8-1","Probable E3 ubiquitin-protein ligase HECTD4 [OS=Homo sapiens]",1,2,2,1,3996,439.1,6.19,7.94,"protein metabolism;other metabolic processes;other biological processes","other membranes","other molecular function","HECTD4","","","","",16.1,19.9,15.8,18.2,16.3,26.2,0.8533772652388797,-0.22874441856912828,0.42050136969818613,0.3762325852373049,0.598062757564515,0.22325324103850486,5139]
["Q9Y4D8-5","Isoform 5 of Probable E3 ubiquitin-protein ligase HECTD4 [OS=Homo sapiens]",3,3,3,2,1321,145,5.78,9.3,"","","","HECTD4","","","","",94.7,93.5,95,111.9,93.2,410,0.46041294098520563,-1.118999710520613,0.34169709880702404,0.46635870858036893,0.5540071196052658,0.25648465407046495,4508]
["Q9Y4E1","WASH complex subunit 2C [OS=Homo sapiens]",31,32,65,7,1318,144.6,4.79,199.88,"","","","","","","","",357.4,318.7,366.3,451,478.4,851.4,0.5853548966756513,-0.7726165087738252,0.13117033288494614,0.8821643792994198,0.3662047223285223,0.43627605963018384,2618]
["Q9Y4E5","E3 SUMO-protein ligase ZNF451 [OS=Homo sapiens]",13,11,16,11,1061,121.4,6.77,39.08,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","ZNF451","ENSG00000112200","","","",880.7,901,889.3,1007.2,845,1862.8,0.7189771197846568,-0.4759822347908486,0.3322962316246264,0.47847458377067276,0.5480038711517136,0.2612163736070731,4432]
["Q9Y4E6-1","WD repeat-containing protein 7 [OS=Homo sapiens]",5,5,8,5,1490,163.7,6.92,26.64,"","ER/Golgi","","WDR7","ENSG00000091157","","","",524.9,520.9,539.3,513.2,514.9,772.1,0.8805132763026331,-0.18358333783647685,0.45229958355280997,0.34457381212319454,0.6190744674508404,0.20825710726777807,5340]
["Q9Y4E8-3","Isoform 3 of Ubiquitin carboxyl-terminal hydrolase 15 [OS=Homo sapiens]",36,27,68,26,956,109.7,5.16,185.84,"","","","USP15","","","","",6572.2,6430,6460.5,6525.1,6498.2,6906.4,0.9765676352378612,-0.03420812896969054,0.3245919755251505,0.4886622208875577,0.5445129100558469,0.26399181893933865,4357]
["Q9Y4F1","FERM, RhoGEF and pleckstrin domain-containing protein 1 [OS=Homo sapiens]",6,5,7,5,1045,118.6,8.15,21.83,"cell-cell signaling;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","FARP1","ENSG00000152767","","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOF GTPase cycle","",334,312.3,366.8,281.2,288.3,566.1,0.8921275096865093,-0.16467816899575882,0.6898713311295914,0.16123190258337172,0.7890875679540194,0.10287479885779893,6390]
["Q9Y4F3-1","Meiosis regulator and mRNA stability factor 1 [OS=Homo sapiens]",1,2,2,2,1742,192.7,7.87,4.99,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","ER/Golgi;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","MARF1","ENSG00000166783; ENSG00000277140","","","",186.5,181.7,200.6,240,228.1,183,0.8735985255721087,-0.19495767355588126,0.20747843312996914,0.683027040443142,0.44865676560560486,0.34808577883682373,3380]
["Q9Y4G6","Talin-2 [OS=Homo sapiens]",8,22,62,2,2542,271.4,5.57,173.61,"cell adhesion;cell organization and biogenesis","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","TLN2","ENSG00000171914","Rap1 signaling pathway; Focal adhesion; Platelet activation; Shigellosis; Human T-cell leukemia virus 1 infection","","Focal adhesion",469.5,405.8,445.4,480.9,430.4,362.1,{"$f":"AVERAGE(S7170:U7170)/AVERAGE(V7170:X7170)","v":1.0371446521124548},{"$f":"LOG(Y7170,2)","v":0.05261712301472672},{"$f":"TTEST(V7170:X7170,S7170:U7170,2,2)","v":0.7074790705839462},0.15028640338579013,{"$f":"AA7170*7309/AE7170","v":0.8020729838526545},0.0957861117129229,6447]
["Q9Y4G8","rap guanine nucleotide exchange factor 2 [OS=Homo sapiens]",6,7,11,5,1499,167.3,6.67,18.79,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","RAPGEF2","ENSG00000109756","MAPK signaling pathway; Rap1 signaling pathway; Tight junction","RAF/MAP kinase cascade","MAPK signaling pathway; Genotoxicity pathway",604.4,522.8,590,543.4,520.3,641.7,1.0069191978421486,0.00994791616534619,0.9344285198613702,{"$f":"-LOG10(AA7171)","v":0.02945391484918659},0.9566799343979205,{"$f":"-LOG10(AC7171)","v":0.01923333492380791},7139]
["Q9Y4H2","Insulin receptor substrate 2 [OS=Homo sapiens]",1,2,3,2,1338,137.2,8.65,4.13,"other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;other molecular function","IRS2","ENSG00000185950","cGMP-PKG signaling pathway; FoxO signaling pathway; Autophagy; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Regulation of lipolysis in adipocytes; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; Growth hormone synthesis, secretion and action; Alzheimer disease; MicroRNAs in cancer","Growth hormone receptor signaling; Interleukin-7 signaling; Signaling by Leptin; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); RAF/MAP kinase cascade; PI3K Cascade; PI3K/AKT activation; Erythropoietin activates Phospholipase C gamma (PLCG); Erythropoietin activates STAT5; Erythropoietin activates RAS; SOS-mediated signalling; IRS activation; Signal attenuation","Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Farnesoid X receptor pathway; Nuclear receptors meta-pathway; Transcription factor regulation in adipogenesis; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; Nonalcoholic fatty liver disease; Insulin signaling; FOXA2 pathway; Alzheimer's disease; EPO receptor signaling; Interferon type I signaling pathways",252,224.2,235.2,347.4,334,420.8,0.6454363999274179,-0.6316531527706554,9.841503300948547E-3,2.006938557519845,0.10898719337368626,0.9626245311777404,660]
["Q9Y4I1-1","Unconventional myosin-Va [OS=Homo sapiens]",33,53,123,1,1855,215.3,8.48,353.17,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYO5A","ENSG00000197535","Pathogenic Escherichia coli infection","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Insulin processing; Translocation of SLC2A4 (GLUT4) to the plasma membrane","Joubert syndrome",112.9,111.6,123.2,118.4,109.5,173.9,0.8653558984569437,-0.208634497005664,0.4282801879565298,0.3682720154006892,0.6039552177839622,0.21899526235624744,5183]
["Q9Y4I1-3","Isoform 3 of Unconventional myosin-Va [OS=Homo sapiens]",32,53,122,1,1880,218.5,8.51,350.7,"","","","MYO5A","","","","",11667.5,11079.5,11634.2,11176,11246,10427.1,1.0466405472296045,0.06576605567042025,0.19022350709480956,0.7207358156281493,0.43191786683937966,0.36459883042978974,3219]
["Q9Y4J8-1","Dystrobrevin alpha [OS=Homo sapiens]",11,7,7,7,743,83.8,6.89,19.38,"cell-cell signaling;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","other molecular function","DTNA","ENSG00000134769","","","",551.3,493.9,565.1,578,597.4,532.9,0.9426330269858921,-0.08523186501507042,0.32280662775577296,0.49105755707199245,0.5432635602733006,0.2649894245502486,4343]
["Q9Y4K3","TNF receptor-associated factor 6 [OS=Homo sapiens]",20,7,9,7,522,59.5,6.44,27.18,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","TRAF6","ENSG00000175104","MAPK signaling pathway; NF-kappa B signaling pathway; Ubiquitin mediated proteolysis; Autophagy; Endocytosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; IL-17 signaling pathway; Neurotrophin signaling pathway; Alcoholic liver disease; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Yersinia infection; Leishmaniasis; Chagas disease; Toxoplasmosis; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis","Ub-specific processing proteases; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; TRAF6 mediated NF-kB activation; activated TAK1 mediates p38 MAPK activation; Ovarian tumor domain proteases; NRIF signals cell death from the nucleus; Regulated proteolysis of p75NTR; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; PIP3 activates AKT signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; TICAM1,TRAF6-dependent induction of TAK1 complex; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway; TRAF6 mediated IRF7 activation; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling","Regulation of toll-like receptor signaling pathway; IL-1 signaling pathway; RANKL/RANK signaling pathway; IL-17 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Melatonin metabolism and effects; Photodynamic therapy-induced NF-kB survival signaling; Interleukin-1 induced activation of NF-kB; TGF-beta signaling pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor (RLR) pathway; MYD88 distinct input-output pathway; ApoE and miR-146 in inflammation and atherosclerosis; Oxidative damage response; Fibrin complement receptor 3 signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; miRNAs involvement in the immune response in sepsis; Signal transduction through IL1R; Interactions between immune cells and microRNAs in tumor microenvironment; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; 16p11.2 proximal deletion syndrome; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Modulators of TCR signaling and T cell activation; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; T-cell receptor (TCR) signaling pathway; Toll-like receptor signaling pathway",848.4,889.3,940.1,910.3,853.5,560.1,1.1522871035758853,0.20450022311661173,0.35051185032682447,0.45529729454597007,0.5597315084200918,0.25202024508929666,4577]
["Q9Y4K4","mitogen-activated protein kinase kinase kinase kinase 5 [OS=Homo sapiens]",2,1,1,1,846,95,7.64,3.44,"","","","","","","","",75.9,76.1,80.3,81.3,95.1,119.7,0.7845322526173591,-0.350095336368746,0.13352458248493998,0.8744387713424998,0.36883264300167284,0.43317064931000904,2646]
["Q9Y4L1","Hypoxia up-regulated protein 1 [OS=Homo sapiens]",63,51,778,51,999,111.3,5.22,2458.55,"stress response;transport;other biological processes","non-structural extracellular;ER/Golgi;other cell component","other molecular function","HYOU1","ENSG00000149428; ENSG00000280682","Protein processing in endoplasmic reticulum","XBP1(S) activates chaperone genes; Scavenging by Class F Receptors","VEGFA-VEGFR2 signaling pathway",78333.3,76734.7,75839.9,68812.9,71997.1,62815.2,1.1339848898859277,0.18140141679524394,0.031051537103586904,1.507916896644146,0.18542131102133716,0.7318403525697155,1224]
["Q9Y4L5","E3 ubiquitin-protein ligase RNF115 [OS=Homo sapiens]",3,1,1,1,304,33.7,5.69,1.74,"protein metabolism;other metabolic processes;other biological processes","cytosol","other molecular function","RNF115","ENSG00000265491","","Antigen processing: Ubiquitination & Proteasome degradation","",48.2,50.5,59.2,97.7,110.1,177.6,0.40970420342501296,-1.287345400435484,0.03888913765631721,1.4101716869696703,0.2044897173597284,0.6893285253397925,1390]
["Q9Y4P1-1","Cysteine protease ATG4B [OS=Homo sapiens]",23,6,17,6,393,44.3,5.07,57.73,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol","other molecular function","ATG4B","ENSG00000168397","Autophagy; Autophagy","Macroautophagy","",1425.5,1339.9,1409.1,1364.8,1383.3,1917.9,0.8946635233604802,-0.16058289793143554,0.42182891183815613,0.37486365735740246,0.5991347680965959,0.22247547734775736,5146]
["Q9Y4P3","Transducin beta-like protein 2 [OS=Homo sapiens]",37,17,53,17,447,49.8,9.44,156.95,"stress response;signal transduction","other membranes;ER/Golgi","other molecular function","TBL2","ENSG00000106638","","","7q11.23 copy number variation syndrome",7576.3,7576.3,7825.7,6861.3,6903.2,6922.4,1.1107657503057489,0.1515545984506798,8.5155079760463681E-4,3.069789439937002,0.036185958021466805,1.441459924960578,172]
["Q9Y4P8-1","WD repeat domain phosphoinositide-interacting protein 2 [OS=Homo sapiens]",28,8,18,1,454,49.4,6.46,61,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","WIPI2","ENSG00000157954","Autophagy; Autophagy; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis","Macroautophagy","Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Alzheimer's disease",949.6,953.5,966.3,982.1,906.8,1595.2,0.8235699319766939,-0.2800369358496542,0.4006014166752457,0.39728751921330135,0.586772696288451,0.2315301029527184,4990]
["Q9Y4P8-6","Isoform 6 of WD repeat domain phosphoinositide-interacting protein 2 [OS=Homo sapiens]",28,8,16,1,443,48.2,6.3,47.61,"","","","WIPI2","","","","",34.8,30.2,32.3,34.5,40.8,48.8,0.7840451248992747,-0.3509914053492453,0.10901180365863956,0.9625264746623968,0.3359052584068282,0.47378319747064884,2372]
["Q9Y4R8","telomere length regulation protein TEL2 homolog [OS=Homo sapiens]",16,9,19,9,837,91.7,5.76,60.21,"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TELO2","ENSG00000100726","Fanconi anemia pathway; mTOR signaling pathway","","Fragile X syndrome; Malignant pleural mesothelioma",856.9,811.4,829.2,872.8,862.6,1042.5,0.8990604413405809,-0.15350998750003012,0.1932359845924356,0.7139119956497402,0.4339053183981911,0.36260502666997796,3255]
["Q9Y4W2","Ribosomal biogenesis protein LAS1L [OS=Homo sapiens]",42,26,58,26,734,83,4.73,167.39,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","LAS1L","ENSG00000001497","","Major pathway of rRNA processing in the nucleolus and cytosol","",6001.8,5747.3,7204.1,5615.1,6194.5,5392.5,1.1017957109887748,0.13985675198072686,0.3153037637080963,0.5012708451483782,0.5389511714084368,0.2684505798011456,4276]
["Q9Y4W6","AFG3-like protein 2 [OS=Homo sapiens]",41,33,106,33,797,88.5,8.66,305.32,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;mitochondrion","other molecular function","AFG3L2","ENSG00000141385","Spinocerebellar ataxia","Processing of SMDT1","Ciliary landscape",13316,14096.6,14007.9,11146.1,11958.6,9982.4,1.2518625083491755,0.3240761202455829,0.011251769888790019,1.948779158221253,0.11550447488366047,0.9374011899741365,712]
["Q9Y4X4-1","Krueppel-like factor 12 [OS=Homo sapiens]",4,2,2,1,402,44.2,9.7,3.52,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","KLF12","ENSCANG00000041690; ENSG00000118922; ENSGGOG00000004142; ENSMFAG00000002684; ENSMLEG00000030485; ENSMMUG00000019097; ENSMNEG00000039444; ENSNLEG00000016131; ENSPANG00000007736; ENSPPAG00000031325; ENSRBIG00000037086; ENSRROG00000027231","","","",26.6,34.1,37.4,44.3,53.6,6.6,0.9387559808612438,-0.09117790074900674,0.8917821707580358,0.049741214671772255,0.9254629967443537,0.03364094118013058,7043]
["Q9Y4X5","E3 ubiquitin-protein ligase ARIH1 [OS=Homo sapiens]",38,15,49,15,557,64.1,5.08,160.36,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","ARIH1","ENSG00000166233","","ISG15 antiviral mechanism","",5149,4953.6,5147.9,5067.9,5179.7,4156.1,1.0587904496761251,0.08241708684901591,0.4413556673974076,0.3552112923153013,0.6114231563699113,0.21365811730565604,5276]
["Q9Y4Y9","U6 snRNA-associated Sm-like protein LSm5 [OS=Homo sapiens]",25,1,2,1,91,9.9,4.54,4.63,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LSM5","ENSG00000106355","RNA degradation; Spliceosome","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease","",19.4,13.8,13.3,19,16.5,4.1,1.174242424242424,0.23173028591578396,0.6696919995442796,0.17412488931904868,0.7733889752992795,0.11160202310962225,6329]
["Q9Y4Z0","U6 snRNA-associated Sm-like protein LSm4 [OS=Homo sapiens]",12,2,4,2,139,15.3,9.99,6.58,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LSM4","ENSG00000130520","RNA degradation; Spliceosome","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease","Ciliary landscape",448.8,447.4,376.5,525.8,525.5,843.3,0.6717512931489497,-0.5740009013987817,0.1287631511861824,0.8902084034835945,0.36267047091322047,0.4404878037840982,2595]
["Q9Y508-1","E3 ubiquitin-protein ligase RNF114 [OS=Homo sapiens]",18,4,6,4,228,25.7,7.25,19.78,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus","other molecular function","RNF114","ENSG00000124226; ENSPPAG00000043607; ENSPTRG00000013613","","Antigen processing: Ubiquitination & Proteasome degradation","",1034.9,993.1,970.9,879,1014.2,967.6,1.0482732102908277,0.06801477390074874,0.35321279663372307,0.4519635706473017,0.561468536449735,0.250674575696589,4598]
["Q9Y512","sorting and assembly machinery component 50 homolog [OS=Homo sapiens]",42,16,73,16,469,51.9,6.9,220.8,"cell organization and biogenesis;transport","other membranes;mitochondrion","","SAMM50","ENSG00000100347","","RAC2 GTPase cycle; Mitochondrial protein import; Cristae formation","",7360.7,7472.1,7760,6283.9,6496.4,4590.5,1.3006194303083336,0.37919888186642337,0.04724733320134926,1.3256226995065368,0.22824240473804477,0.6416036656457506,1513]
["Q9Y519","Transmembrane protein 184B [OS=Homo sapiens]",2,1,1,1,407,45.5,6.89,2.07,"","other membranes","","TMEM184B","ENSG00000198792","","","",52.6,56.4,61.4,46.4,60.4,34.5,1.2059447983014862,0.27016386989189883,0.28716961843957406,0.5418615088656312,0.519406765942798,0.28449239742430626,4041]
["Q9Y520-7","Isoform 7 of Protein PRRC2C [OS=Homo sapiens]",23,56,122,54,2898,316.9,9.13,331.37,"","","","PRRC2C","","","","",14091,12987.5,13962.1,20416.6,21211.3,19705.6,0.6691383990804374,-0.579623457986578,2.6417482331880771E-4,3.5781085743623864,0.025076023164119034,1.6007413376508954,77]
["Q9Y535","DNA-directed RNA polymerase III subunit RPC8 [OS=Homo sapiens]",27,3,6,3,204,22.9,4.58,24.95,"RNA metabolism OR transcription;other metabolic processes;stress response","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","POLR3H","ENSG00000100413","RNA polymerase; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway",387,442.4,418.2,428.3,476.3,650.8,0.8021087823068019,-0.31813018607254445,0.213798652002664,0.6699950373388881,0.4553188658180278,0.3416843546315829,3432]
["Q9Y547","Intraflagellar transport protein 25 homolog [OS=Homo sapiens]",42,4,11,4,144,16.3,5.03,43.54,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","other molecular function","HSPB11","ENSG00000081870","","Intraflagellar transport","Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); GDNF/RET signaling axis",693.1,707.8,732.6,737.8,630.3,562.4,1.1051541051541052,0.14424755625925345,0.2657411571541604,0.5755411782178307,0.5021463592657079,0.29916968174482184,3868]
["Q9Y548","Protein YIPF1 [OS=Homo sapiens]",8,3,3,3,306,34.3,5.31,9.76,"transport","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle","other molecular function","YIPF1","ENSG00000058799","","","",415.1,472.7,448.4,407.1,437.9,248.1,1.2223950233281493,0.28971057493065916,0.25563539778975647,0.5923790096671553,0.49195342876390996,0.308076008184181,3798]
["Q9Y570","Protein phosphatase methylesterase 1 [OS=Homo sapiens]",38,11,21,11,386,42.3,5.97,56.27,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","nucleus","enzyme regulator activity;other molecular function","PPME1","ENSG00000214517","","Cyclin A/B1/B2 associated events during G2/M transition","",2352.6,2455.8,2568.9,2407.3,2241.3,2353.2,1.0536290668113912,0.07536705135836741,0.1896771821290258,0.7219849109220294,0.43161597888575637,0.36490248564469985,3212]
["Q9Y572-1","Receptor-interacting serine/threonine-protein kinase 3 [OS=Homo sapiens]",7,3,3,3,518,56.9,6.47,9.74,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","RIPK3","ENSG00000129465; ENSG00000285379","Necroptosis; NOD-like receptor signaling pathway; Cytosolic DNA-sensing pathway; TNF signaling pathway; Salmonella infection","Regulation of necroptotic cell death; IKK complex recruitment mediated by RIP1; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; TRIF-mediated programmed cell death; TLR3-mediated TICAM1-dependent programmed cell death; TRP channels; Microbial modulation of RIPK1-mediated regulated necrosis","TNF-alpha signaling pathway; Nanoparticle triggered regulated necrosis; Cytosolic DNA-sensing pathway",162,166,177.3,165.4,163.6,189.6,0.9743540300809872,-0.03748202623534198,0.6667223286097237,0.17605500005726238,0.7715442526612525,0.11263915950954603,6316]
["Q9Y575","Ankyrin repeat and SOCS box protein 3 [OS=Homo sapiens]",2,1,1,1,518,57.7,6.27,2.27,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol","","ASB3","ENSG00000115239","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",76.8,82.2,78.5,155.4,146.1,289.7,0.40172530446549387,-1.3157187560404786,0.0639975070382064,1.1938369432135763,0.26117128919165306,0.5830745671786347,1791]
["Q9Y580","RNA-binding protein 7 [OS=Homo sapiens]",6,2,5,2,266,30.5,9.57,13.63,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","RBM7","ENSG00000076053","","","",478.9,491.9,474.2,584.2,643.4,620,0.782095691708162,-0.35458295857363326,1.7327402323874736E-3,2.7612665406310217,0.0490875905368994,1.309028284710279,258]
["Q9Y587-1","AP-4 complex subunit sigma-1 [OS=Homo sapiens]",7,1,1,1,144,17,5.19,2.06,"transport;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","AP4S1","ENSCANG00000008358; ENSCATG00000035780; ENSG00000100478; ENSGGOG00000003198; ENSMMUG00000003123; ENSPANG00000017427; ENSPCOG00000016646; ENSPPAG00000041450; ENSPTRG00000006239; ENSRROG00000019504","Lysosome","Lysosome Vesicle Biogenesis","",34.5,34.8,35.9,30.7,30,18.3,1.3316455696202532,0.41321014622783714,0.09694654419551817,1.0134676673853424,0.3191812123986677,0.49596267995200816,2220]
["Q9Y592","Centrosomal protein of 83 kDa [OS=Homo sapiens]",2,2,2,2,693,82,6.28,4.99,"","","","","","","","",47.8,50.9,48.4,76.9,55.6,32.7,0.8904358353510896,-0.16741644016461524,0.6618858932751859,0.17921687489915172,0.7683805581239411,0.11442363236618693,6296]
["Q9Y597","BTB/POZ domain-containing protein KCTD3 [OS=Homo sapiens]",1,1,1,1,815,88.9,7.03,3.19,"cell organization and biogenesis","plasma membrane;other membranes","","KCTD3","ENSG00000136636","","CDC42 GTPase cycle","",97.9,99.2,98.1,203.7,200.9,316.9,0.4091476091476092,-1.2893066733181642,0.020494987692283365,1.6883523381513352,0.1528549643294889,0.8157204519598571,980]
["Q9Y5A7","NEDD8 ultimate buster 1 [OS=Homo sapiens]",25,15,24,15,615,70.5,5.96,68.07,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus","","NUB1","ENSG00000013374","","","",3065.1,3079.2,3191.5,3527.5,3518,3302.6,0.9021752785535507,-0.1485203410810888,0.015663044975476628,1.8051238050177623,0.13548070500089784,0.8681225520834817,845]
["Q9Y5A9-1","YTH domain-containing family protein 2 [OS=Homo sapiens]",16,9,24,6,579,62.3,8.79,62.04,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity","YTHDF2","ENSCSAG00000001018; ENSG00000198492; ENSMFAG00000026128; ENSMMUG00000011391; ENSMNEG00000041161; ENSNLEG00000009856; ENSPTRG00000000439; ENSRBIG00000043898; ENSRROG00000038863","","","",1062,1073.7,1064.4,1897.1,1811.7,1087.1,0.6672574490710816,-0.5836845885959218,0.10723425089828384,0.9696664776999752,0.33352133609172624,0.4768763780877384,2350]
["Q9Y5B0","RNA polymerase II subunit A C-terminal domain phosphatase [OS=Homo sapiens]",12,10,17,10,961,104.3,5.27,44.42,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","CTDP1","ENSG00000060069","","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat","",1191,1109.3,1130,1329.1,1355.8,2080.4,0.7198497471302963,-0.4742322879036972,0.1463629839351897,0.834568745035545,0.3830172035740428,0.41678171885257714,2793]
["Q9Y5B6","PAX3- and PAX7-binding protein 1 [OS=Homo sapiens]",14,11,23,11,917,104.7,5.68,71.3,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus","nucleic acid binding activity","PAXBP1","ENSG00000159086; ENSG00000263141","","","",2614.6,2507.5,2581.7,2689.1,2771.9,1931.6,1.0420961502042583,0.05948839568100635,0.7196399997920708,0.14288470524007865,0.8107041859556483,0.09113758455920527,6488]
["Q9Y5B8","Nucleoside diphosphate kinase 7 [OS=Homo sapiens]",11,4,5,4,376,42.5,6.47,11.96,"other metabolic processes","cytosol;cytoskeleton","kinase activity;other molecular function","NME7","ENSG00000143156","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors","Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes","Pyrimidine metabolism; Ciliopathies",425.3,390.8,426,407.5,395.5,324.7,1.1014454198811738,0.13939800668863803,0.24945564541463447,0.6030066631231533,0.48517065256401365,0.3141054770036872,3758]
["Q9Y5B9","FACT complex subunit SPT16 [OS=Homo sapiens]",41,44,216,44,1047,119.8,5.66,598.2,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus","other molecular function","SUPT16H","ENSG00000092201","","Regulation of TP53 Activity through Phosphorylation; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes","",30175.6,30478.9,30672.7,26839.8,27284.2,20747.8,1.2197810123437662,0.2866221635556306,0.06035443511370779,1.2192908104939346,0.25543171178117563,0.5927251861774203,1727]
["Q9Y5J1","U3 small nucleolar RNA-associated protein 18 homolog [OS=Homo sapiens]",23,8,18,8,556,62,8.76,49.37,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","","UTP18","ENSG00000011260","Ribosome biogenesis in eukaryotes","rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol","",884.9,872.7,869.7,1495.9,1639.9,1342.2,0.5867128182224207,-0.7692735832191324,0.002006869613852705,2.6974808426713284,0.053145688433512396,1.274531962852573,276]
["Q9Y5J6","Mitochondrial import inner membrane translocase subunit Tim10 B [OS=Homo sapiens]",24,1,1,1,103,11.6,7.43,2.04,"cell adhesion;cell organization and biogenesis;transport","other membranes;mitochondrion","transporter activity;other molecular function","TIMM10B","ENSG00000132286","","Mitochondrial protein import","",54.5,61.9,67.7,47.6,58.8,23,1.4227202472952087,0.508652009357399,0.18014445761269435,0.7443790949915974,0.42309634983649835,0.3735607214252758,3112]
["Q9Y5J9","mitochondrial import inner membrane translocase subunit Tim8 B [OS=Homo sapiens]",13,1,2,1,83,9.3,5.12,3.6,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","TIMM8B","ENSG00000150779","","Mitochondrial protein import","",182.1,165.3,151.4,156.4,221.5,417.9,0.6267906509173159,-0.6739444338640674,0.278899551252041,0.5545521845109997,0.5126953772890261,0.2901405983523025,3976]
["Q9Y5K5-1","Ubiquitin carboxyl-terminal hydrolase isozyme L5 [OS=Homo sapiens]",61,15,80,1,329,37.6,5.33,271.77,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","UCHL5","ENSCANG00000036448; ENSCATG00000035323; ENSG00000116750; ENSGGOG00000004347; ENSMFAG00000038349; ENSMLEG00000030039; ENSMNEG00000039813; ENSPPAG00000029294; ENSPTRG00000001793","","UCH proteinases; Downregulation of TGF-beta receptor signaling","TGF-beta signaling pathway",167.8,165.2,195.8,204.5,189.6,173.9,0.9309859154929576,-0.10316875288435293,0.37796228405056737,0.42255153520495203,0.5736142720360459,0.24138005157074724,4816]
["Q9Y5K5-3","Isoform 3 of Ubiquitin carboxyl-terminal hydrolase isozyme L5 [OS=Homo sapiens]",61,15,82,1,328,37.5,5.4,278.15,"","","","UCHL5","","","","",8532.5,8611.8,8858.3,8897.7,8331.1,9127.4,0.986583801913781,-0.019486494044414045,0.6693196572217458,0.17436642003225244,0.7733255413584793,0.11163764572798351,6326]
["Q9Y5K6","CD2-associated protein [OS=Homo sapiens]",41,23,57,23,639,71.4,6.4,150.5,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","CD2AP","ENSG00000198087","Bacterial invasion of epithelial cells","Nephrin family interactions","Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome; Genes controlling nephrogenesis",6957.7,6661.1,7064.1,7636.1,8096.1,4549.7,1.019771323199503,0.02824567388949853,0.9107496339666388,0.04060099463043399,0.940340312849578,0.026714945075311167,7079]
["Q9Y5K8","V-type proton ATPase subunit D [OS=Homo sapiens]",39,11,36,11,247,28.2,9.36,101.86,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol","transporter activity","ATP6V1D","ENSG00000100554","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis","Neutrophil degranulation; Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Proximal tubule transport",4006.6,3935.7,3811.8,3850.9,3964.1,3413.4,1.0468187809483096,0.0660117130846869,0.3789272544808085,0.421444156812785,0.5738871328222604,0.24117351250157915,4826]
["Q9Y5L0-2","transportin-3 [OS=Homo sapiens]",31,23,71,23,923,104.1,5.57,225.81,"transport","other membranes;nucleus;other cell component","other molecular function","TNPO3","ENSCANG00000033070; ENSCATG00000030018; ENSG00000064419; ENSGGOG00000008339; ENSMLEG00000037881; ENSMMUG00000004311; ENSMNEG00000045277; ENSPPAG00000034975; ENSPPYG00000017990; ENSPTRG00000019676","Nucleocytoplasmic transport","","",7048.3,7505.2,7065.1,7307.7,7200.5,6476.4,1.0302126321206981,0.04294213512351726,0.5211719126338412,0.28301899763486493,0.6698163371620794,0.1740442640030595,5687]
["Q9Y5M8","signal recognition particle receptor subunit beta [OS=Homo sapiens]",50,11,82,11,271,29.7,9.04,282.32,"transport","other membranes;cytoskeleton;ER/Golgi;other cell component","other molecular function","SRPRB","ENSG00000144867","Protein export","XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane","",9615.1,9696.6,9633.4,8627.2,9191.7,9045.2,1.0774639760870455,0.10763963507829853,0.015367226131022798,1.8134045179725455,0.13435293754981534,0.8717528335275889,836]
["Q9Y5N5","HemK methyltransferase family member 2 [OS=Homo sapiens]",24,5,9,5,214,22.9,5.11,21.42,"protein metabolism;DNA metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","N6AMT1","ENSG00000156239","","Eukaryotic Translation Termination; Methylation","",733.1,817.3,785.8,792.9,870.4,1349,0.7755535637220727,-0.366701670237729,0.2687055829722674,0.5707233100132055,0.5047466219337708,0.2969265789329751,3891]
["Q9Y5N6","Origin recognition complex subunit 6 [OS=Homo sapiens]",7,1,1,1,252,28.1,8.66,2.55,"DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","ORC6","ENSG00000091651","Cell cycle","Assembly of the ORC complex at the origin of replication; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation","Cell cycle; G1 to S cell cycle control; DNA replication",77.7,76.6,75.5,95.5,93.2,97.6,0.8026545581557808,-0.3171488723532394,1.8702316788142757E-4,3.7281045910045183,0.022047618291054095,1.6566383186187994,62]
["Q9Y5P4-1","Collagen type IV alpha-3-binding protein [OS=Homo sapiens]",24,14,34,14,624,70.8,5.48,79.24,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus","transporter activity;kinase activity;other molecular function","CERT1","ENSG00000113163; ENSPTRG00000016996","","","Sphingolipid pathway",3083,3153,3061.6,3195.8,3106.1,2711.5,1.0315308318725454,0.044786943206811675,0.5651688031127484,0.24782181888631735,0.6984813631976798,0.15584517719244317,5914]
["Q9Y5P6","Mannose-1-phosphate guanyltransferase beta [OS=Homo sapiens]",45,11,38,11,360,39.8,6.61,132.58,"other metabolic processes","other cell component","other molecular function","GMPPB","ENSG00000173540","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars","Synthesis of GDP-mannose","",4030.7,4265.5,4139.4,4114.9,3863.4,3937.3,1.0436402698982847,0.061624518165731,0.16081660342991302,0.7936691147558356,0.39939128592226786,0.39860141497147356,2943]
["Q9Y5Q8-1","general transcription factor 3C polypeptide 5 [OS=Homo sapiens]",23,10,18,10,519,59.5,6.9,39.12,"RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","nucleic acid binding activity","GTF3C5","ENSG00000148308","","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter","",1233.5,1232.9,1278.2,1287.4,1269,1408.4,0.9444612590799031,-0.08243647506523961,0.18751097162206615,0.7269733158001768,0.4304389734879653,0.36608841298183525,3184]
["Q9Y5Q9","General transcription factor 3C polypeptide 3 [OS=Homo sapiens]",23,14,28,14,886,101.2,5.07,89.01,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","nucleic acid binding activity","GTF3C3","ENSG00000119041","","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter","",1434.5,1528.6,1644.1,1570.2,1521.3,1454.1,1.0135515663498769,0.019419490506569378,0.7818342265373561,0.10688532127785377,0.8516283698601395,0.0697498795628729,6710]
["Q9Y5R8","trafficking protein particle complex subunit 1 [OS=Homo sapiens]",4,1,1,1,145,16.8,9.16,1.79,"transport","non-structural extracellular;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","TRAPPC1","ENSG00000170043","","Neutrophil degranulation; COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs","",71.8,70.5,77.6,68.9,89.6,53.9,1.0353107344632768,0.05006383805081441,0.8247623130180248,0.08367119207741466,0.8809276261652409,0.055059770189752714,6843]
["Q9Y5S1","Transient receptor potential cation channel subfamily V member 2 [OS=Homo sapiens]",17,7,12,7,764,85.9,5.83,30.85,"cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","transporter activity","TRPV2","ENSG00000187688","NOD-like receptor signaling pathway; Inflammatory mediator regulation of TRP channels","TRP channels","",973.7,1023.4,1015.3,936.5,977.1,2221.9,0.7284246161286422,-0.45714841781335164,0.4252765519303847,0.37132856190853814,0.6015766050046801,0.22070906157022682,5167]
["Q9Y5S2","Serine/threonine-protein kinase MRCK beta [OS=Homo sapiens]",3,4,5,4,1711,194.2,6.37,8.61,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","kinase activity;other molecular function","CDC42BPB","ENSG00000198752","","CDC42 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle","VEGFA-VEGFR2 signaling pathway",781.1,818.7,1418.8,769.1,636.6,212.7,1.865175481957489,0.8993113704483758,0.15435461829421832,0.8114803718852274,0.3921369152285164,0.40656227189158045,2877]
["Q9Y5S9","RNA-binding protein 8A [OS=Homo sapiens]",47,7,39,1,174,19.9,5.72,112.15,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","RBM8A","ENSG00000265241","Nucleocytoplasmic transport; mRNA surveillance pathway; Spliceosome","Regulation of expression of SLITs and ROBOs; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); RNA Polymerase II Transcription Termination; mRNA 3'-end processing; Transport of Mature mRNA derived from an Intron-Containing Transcript","",1673.8,1515.5,1571.1,1846.1,1465,3052.4,0.7480788874047302,-0.41873767976571263,0.32858234618909593,0.4833557737025958,0.5458200837036595,0.26295048830481027,4400]
["Q9Y5S9-2","Isoform 2 of RNA-binding protein 8A [OS=Homo sapiens]",47,7,32,1,173,19.7,5.92,94.61,"","","","RBM8A","","","","",3052.7,2871.4,2850.8,3466.6,2847,2293.7,1.0194718436675847,0.0278219307619773,0.8791356174684898,0.05594412449947329,0.9170261492903086,0.03761828010907577,7007]
["Q9Y5T5-2","Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 16 [OS=Homo sapiens]",23,13,22,13,822,93.4,6.93,70.14,"","","","USP16","","","","",1593.2,1605.1,1590.5,1776.4,1733.1,2003,0.8687165532879818,-0.20304256672150678,0.04508669439791096,1.3459516045109536,0.22251090435808993,0.6526487011481891,1481]
["Q9Y5U2-1","Protein TSSC4 [OS=Homo sapiens]",13,4,9,4,329,34.3,5.19,23.79,"","","","TSSC4","ENSG00000184281","","","",747.9,709.4,762,775.7,803,1294,0.7725484735614581,-0.37230263711601475,0.2672876775852243,0.5730210624933574,0.5036364102785266,0.29788288020944087,3879]
["Q9Y5U8","Mitochondrial pyruvate carrier 1 [OS=Homo sapiens]",27,2,4,2,109,12.3,9.61,11.35,"transport","other membranes;mitochondrion","transporter activity","MPC1","ENSG00000060762","Diabetic cardiomyopathy","Pyruvate metabolism","Glycolysis and gluconeogenesis",413.9,406.6,511.6,385.6,313,619.3,1.0107747173533652,0.015461483517708272,0.9639446544996615,0.015947900677470265,0.9752867496868807,0.010867676098946675,7224]
["Q9Y5U9","immediate early response 3-interacting protein 1 [OS=Homo sapiens]",24,1,9,1,82,9,8.22,48,"transport;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","","IER3IP1","ENSG00000134049","","","",1052.9,1107.5,1031.9,762.7,929.2,355.5,{"$f":"AVERAGE(S7234:U7234)/AVERAGE(V7234:X7234)","v":1.5591970303799942},{"$f":"LOG(Y7234,2)","v":0.6408032479787488},{"$f":"TTEST(V7234:X7234,S7234:U7234,2,2)","v":0.09058440892947216},1.042946545133056,{"$f":"AA7234*7309/AE7234","v":0.30794485807698235},0.5115270431646882,2150]
["Q9Y5W8","Sorting nexin-13 [OS=Homo sapiens]",4,3,3,3,968,112.1,6.58,8.65,"transport;other biological processes","other membranes;other cytoplasmic organelle","other molecular function","SNX13","ENSG00000071189","","","",144.3,160,151,170.2,173.9,246.2,0.7713027274267323,-0.3746308824283672,0.14813100946919958,{"$f":"-LOG10(AA7235)","v":0.8293540175648269},0.38543593741914545,{"$f":"-LOG10(AC7235)","v":0.4140477948824321},2809]
["Q9Y5W9","Sorting nexin-11 [OS=Homo sapiens]",5,1,1,1,270,30.4,7.05,3.13,"cell organization and biogenesis;transport","other membranes;other cytoplasmic organelle","other molecular function","SNX11","ENSG00000002919","","","",57.7,78.4,72.8,62.3,59.7,130.6,0.8269992082343627,-0.2740421467204439,0.5769746381453942,0.23884327654198603,0.7076871337816221,0.15015870008279986,5959]
["Q9Y5X2","Sorting nexin-8 [OS=Homo sapiens]",15,6,8,6,465,52.5,7.39,23.67,"transport","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","SNX8","ENSG00000106266","","","",640.2,646.4,660.5,600.9,604.8,1394.9,0.748711835730216,-0.41751753395556945,0.4558032106502806,0.3412226200007743,0.6220062857809748,0.20620522645677267,5356]
["Q9Y5X3","sorting nexin-5 [OS=Homo sapiens]",45,16,60,15,404,46.8,6.76,184.77,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","SNX5","ENSG00000089006","Endocytosis","Golgi Associated Vesicle Biogenesis","",7860.1,7813.8,7863.3,8027.7,7461.4,3522,1.2380767025579795,0.3081006965975251,0.34702901002635994,0.45963421867382787,0.557090936587451,0.2540739070980448,4553]
["Q9Y5Y0","Feline leukemia virus subgroup C receptor-related protein 1 [OS=Homo sapiens]",2,1,1,1,555,59.8,5.97,3.04,"other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion","transporter activity;other molecular function","FLVCR1","ENSG00000162769","","","",194.4,181.1,165.6,199.4,222.3,293.4,0.7566773877779331,-0.40224976199199547,0.12068745620641798,0.9183378664679498,0.3510165608486705,0.45467239317655284,2513]
["Q9Y5Y2","Cytosolic Fe-S cluster assembly factor NUBP2 [OS=Homo sapiens]",42,8,17,8,271,28.8,5.83,54.52,"cell organization and biogenesis;other metabolic processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","NUBP2","ENSG00000095906","","Cytosolic iron-sulfur cluster assembly","",1958.7,2012.2,2033.1,1820.8,1755.8,2313.3,1.0193721455372757,0.027680837084325793,0.8407194516561296,0.07534890423123393,0.8918459320979175,0.04971016425488675,6890]
["Q9Y5Y5","Peroxisomal membrane protein PEX16 [OS=Homo sapiens]",15,3,8,3,336,38.6,9.85,31.89,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","other molecular function","PEX16","ENSG00000121680","Peroxisome","Class I peroxisomal membrane protein import","",579,664.6,583.4,905.4,593.5,1253.7,0.6637361040470827,-0.5913183428609196,0.18460811055429627,0.7337492226405552,0.4280776269166724,0.3684774695741,3152]
["Q9Y5Y6","suppressor of tumorigenicity 14 protein [OS=Homo sapiens]",20,16,31,16,855,94.7,6.55,89.97,"protein metabolism;developmental processes","non-structural extracellular;plasma membrane;other membranes","other molecular function","ST14","ENSG00000149418","MicroRNAs in cancer","Formation of the cornified envelope","",3610.3,3599.8,3412.1,3261.2,3742.2,4199.6,0.9481567437293582,-0.07680251813884947,0.5251829692250755,0.2796893657727653,0.6713120535267709,0.17307555491076243,5718]
["Q9Y5Z7","host cell factor 2 [OS=Homo sapiens]",11,7,15,6,792,86.7,8.48,42.05,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","HCFC2","ENSG00000111727","Herpes simplex virus 1 infection","","",861.7,909.1,935.4,1041.4,1061.4,1913.2,0.6738545816733068,-0.5694908045692945,0.2042805333209299,0.6897730169902072,0.44490060132380116,0.35173700726289686,3356]
["Q9Y5Z9-1","UbiA prenyltransferase domain-containing protein 1 [OS=Homo sapiens]",8,2,3,2,338,36.8,8.15,6.32,"other metabolic processes;other biological processes","other membranes;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","UBIAD1","ENSG00000120942; ENSGGOG00000001270","","Metabolism of vitamin K","7q11.23 copy number variation syndrome",107.4,113.1,108.3,118.8,131.8,200.7,0.7285619321958786,-0.45687647953080435,0.18420256952824265,0.7347043159190096,0.42795186925681045,0.3686050723223047,3146]
["Q9Y606","tRNA pseudouridine synthase A [OS=Homo sapiens]",36,15,26,15,427,47.4,8.41,75.22,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","PUS1","ENSG00000177192","","","",2369.4,2350.6,2357.3,2236.3,2178.9,2185.3,1.0722369517460797,0.10062375965193697,0.001111492461365424,2.954093478532692,0.04187576494907156,1.3780372465789452,194]
["Q9Y608","Leucine-rich repeat flightless-interacting protein 2 [OS=Homo sapiens]",5,3,11,2,721,82.1,6.95,36.04,"cell-cell signaling;signal transduction;other biological processes","","other molecular function","LRRFIP2","ENSG00000093167","","","VEGFA-VEGFR2 signaling pathway; Genotoxicity pathway",388.1,293.6,388.6,429.2,512.2,243.6,0.9032067510548524,-0.14687182525457493,0.6777298608553324,0.16894337887377583,0.7795919976379642,0.10813262748093151,6354]
["Q9Y613","FH1/FH2 domain-containing protein 1 [OS=Homo sapiens]",38,33,92,33,1164,126.5,6.39,245.41,"cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","FHOD1","ENSG00000135723","Salmonella infection","","VEGFA-VEGFR2 signaling pathway",6013.7,6097.6,6040.7,6514.9,6516.3,8005.6,0.8628688773958016,-0.21278675252061038,0.12527954166399718,0.9021198441523595,0.35852316758894104,0.445482775195783,2554]
["Q9Y617-1","phosphoserine aminotransferase [OS=Homo sapiens]",65,21,89,20,370,40.4,7.66,269.38,"other metabolic processes","cytosol;other cell component","other molecular function","PSAT1","ENSG00000135069; ENSGGOG00000015480; ENSPPAG00000036829; ENSPTRG00000021045","Glycine, serine and threonine metabolism; Cysteine and methionine metabolism; Vitamin B6 metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; Biosynthesis of cofactors","Serine biosynthesis","Trans-sulfuration and one-carbon metabolism; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Male infertility; Neuroinflammation and glutamatergic signaling",11538.9,11923.8,11524.9,15848.9,15281.6,15400.3,0.7519234571509623,-0.41134228618803853,5.9019328187533687E-5,4.229005738348556,0.014379075657422791,1.8422690311842453,30]
["Q9Y619","mitochondrial ornithine transporter 1 [OS=Homo sapiens]",5,2,2,2,301,32.7,9.13,2.12,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","SLC25A15","ENSG00000102743","","Urea cycle","",61.5,60,57.7,55,55.8,200.5,0.575650497911982,-0.7967349394115755,0.4142233976980055,0.3827653733224838,0.5943382045101535,0.2259663520661071,5094]
["Q9Y624","Junctional adhesion molecule A [OS=Homo sapiens]",51,12,52,12,299,32.6,7.9,148.06,"cell adhesion;cell organization and biogenesis;stress response;transport;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","F11R","ENSG00000158769","Cell adhesion molecules; Tight junction; Leukocyte transendothelial migration; Epithelial cell signaling in Helicobacter pylori infection","Integrin cell surface interactions; Cell surface interactions at the vascular wall; Tight junction interactions; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)","1q21.1 copy number variation syndrome",6981.9,7224.3,6921.8,5188.2,5535.4,5637.2,1.2913793946506285,0.36891291262803955,6.406770570011142E-4,3.1933608280546837,0.03274621405329471,1.4848389036357723,143]
["Q9Y639-1","Isoform 1 of Neuroplastin [OS=Homo sapiens]",11,3,5,3,282,31.3,6.87,17.58,"","","","NPTN","","","","",906.5,909.6,857.4,973.3,1006.2,1224.5,0.8344257178526842,-0.2611444710100919,0.09332706824620038,1.0299923767784698,0.3133337353291128,0.5039928439355911,2177]
["Q9Y657","Spindlin-1 [OS=Homo sapiens]",37,7,7,5,262,29.6,6.96,20.32,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;signal transduction;other biological processes","other membranes;cytosol;nucleus","other molecular function","SPIN1","ENSG00000106723","","","",373.4,387.1,379.6,406.6,441.5,824.5,0.68163338514887,-0.5529320970448725,0.25567113346676634,0.5923183031969305,0.4918926861038682,0.3081296348676778,3799]
["Q9Y666","Solute carrier family 12 member 7 [OS=Homo sapiens]",8,8,13,7,1083,119,6.71,26.59,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;other cell component","transporter activity;other molecular function","SLC12A7","ENSG00000113504","Collecting duct acid secretion","Cation-coupled Chloride cotransporters","",563.5,574.6,571.4,513.3,557.1,880.5,0.8762622379414629,-0.19056540684065643,0.5255177842590312,0.27941258225253884,0.6716225712798145,0.17287471691523815,5719]
["Q9Y672","Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase [OS=Homo sapiens]",10,5,17,5,507,58.1,8.46,38.32,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","ALG6","ENSG00000088035","N-Glycan biosynthesis; Metabolic pathways","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG6 causes CDG-1c","GPCRs, other",1943.9,2037.8,2070.5,1533.1,1630.4,1181.4,1.3929434509424843,0.478136690314738,0.015859480478366463,1.799711043315649,0.1355753717150649,0.8678191961598485,855]
["Q9Y673","dolichyl-phosphate beta-glucosyltransferase [OS=Homo sapiens]",37,13,32,13,324,36.9,9.28,77.45,"protein metabolism;other metabolic processes;developmental processes","other membranes;ER/Golgi","other molecular function","ALG5","ENSG00000120697","N-Glycan biosynthesis; Metabolic pathways","Synthesis of dolichyl-phosphate-glucose","",3207.2,3235.8,3361.2,2769.5,2689.6,1998.1,1.3147293890468272,0.3947658799309793,0.03496583714481493,1.4563560695109317,0.1937568640572042,0.712742903173324,1319]
["Q9Y676","28S ribosomal protein S18b, mitochondrial [OS=Homo sapiens]",17,3,6,3,258,29.4,9.38,16.02,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus;other cell component","other molecular function","MRPS18B","ENSG00000203624; ENSG00000204568; ENSG00000223775; ENSG00000226111; ENSG00000227420; ENSG00000229861; ENSG00000233813","Viral carcinogenesis","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",196.3,210.3,231.8,191.5,178.6,205.2,1.1096819050929954,0.15014618133810767,0.1774618135967452,0.7508950844589454,0.41962743305681355,0.3771361276382774,3091]
["Q9Y678","Coatomer subunit gamma-1 [OS=Homo sapiens]",67,46,229,42,874,97.7,5.47,675.39,"transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","COPG1","ENSG00000181789","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport","VEGFA-VEGFR2 signaling pathway",21730.4,22228.3,22886,22028.2,21004.3,20110,1.0586324583283842,0.08220179368915578,0.12929835374728735,0.8884070046093229,0.363198181221723,0.4398563349509174,2602]
["Q9Y679-1","Ancient ubiquitous protein 1 [OS=Homo sapiens]",13,6,16,6,476,53,8.09,46.26,"","","","","","","","",1710,1714.4,1735,1504.1,1496.8,2531.5,0.9325789892270986,-0.10070216840420425,0.7358945873213598,0.1331843914007771,0.8212938675724262,0.08550141994560574,6549]
["Q9Y689-1","ADP-ribosylation factor-like protein 5A [OS=Homo sapiens]",4,1,1,1,179,20.7,6.79,2.51,"transport;other biological processes","ER/Golgi","other molecular function","ARL5A; LOC111161526","ENSAMEG00000008735; ENSANAG00000027698; ENSCANG00000029546; ENSCATG00000029667; ENSCCAG00000023321; ENSCJAG00000040846; ENSECAG00000023672; ENSFCAG00000014742; ENSG00000162980; ENSGGOG00000002066; ENSLCNG00005010847; ENSMMUG00000010521; ENSMNEG00000035230; ENSMPUG00000000396; ENSNVIG00000004853; ENSOCUG00000035346; ENSOGAG00000011424; ENSPANG00000009772; ENSPPAG00000033494; ENSPTRG00000012538; ENSRBIG00000031831; ENSRFEG00010001991; ENSRROG00000040290; ENSSBOG00000034323; ENSSSCG00000031541; ENSSSCG00070004184; ENSSSUG00005001466","","","",44.5,34,47.4,40.5,34.5,84.8,0.7878598247809762,-0.3439891252089604,0.5281078716783042,0.2772773591144731,0.6718782304781071,0.17270943025480412,5745]
["Q9Y692-1","Glucocorticoid modulatory element-binding protein 1 [OS=Homo sapiens]",8,4,8,4,573,62.6,4.83,26.33,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","GMEB1","ENSG00000162419; ENSGGOG00000009221; ENSPPAG00000038756","","","",287.7,314.2,306.2,328.5,354.8,419.1,0.8237481857764876,-0.27972471215562195,0.08198224187479147,1.0862802097016528,0.293011347610196,0.5331155601610406,2045]
["Q9Y696","Chloride intracellular channel protein 4 [OS=Homo sapiens]",74,15,147,13,253,28.8,5.59,511.58,"transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","transporter activity","CLIC4","ENSG00000169504","","","",13805,12351.8,12265.7,13157.6,13710.3,10461.1,1.0292935787189585,0.04165453145809808,0.7613745988515409,0.11840161630892074,0.8385905580177686,0.07645003177727086,6636]
["Q9Y697","Cysteine desulfurase, mitochondrial [OS=Homo sapiens]",48,15,40,15,457,50.2,8.31,118.05,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytosol;mitochondrion;nucleus","other molecular function","NFS1","ENSG00000244005","Thiamine metabolism; Metabolic pathways; Biosynthesis of cofactors; Sulfur relay system","","",3123.7,3112.2,3215.8,2905,2766.2,3445.4,1.0367571243665403,0.0520779611604041,0.6225711007467429,0.20581104278860615,0.7412236806251741,0.1300507142849306,6139]
["Q9Y6A4","Cilia- and flagella-associated protein 20 [OS=Homo sapiens]",38,7,19,7,193,22.8,9.76,47.39,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","","CFAP20","ENSG00000070761","","","",2085.5,2236.8,2362.4,2314.3,1875.6,1614.5,1.151660809041417,0.20371587201533836,0.2518888555977103,0.5987910467118305,0.48847324106226175,0.31115922227746245,3769]
["Q9Y6A5","Transforming acidic coiled-coil-containing protein 3 [OS=Homo sapiens]",32,22,51,22,838,90.3,5.05,162.76,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","","TACC3","ENSG00000013810","","Negative regulation of NOTCH4 signaling; NOTCH3 Activation and Transmission of Signal to the Nucleus","",4634,4269.1,4165.5,4256.7,4354.1,6058.6,0.8908748824082784,-0.16670526606271982,0.4255464106594222,0.37105306826062884,0.6018418567162765,0.2205176113636835,5168]
["Q9Y6A9","Signal peptidase complex subunit 1 [OS=Homo sapiens]",17,2,7,2,102,11.8,9.31,25.02,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","translation activity;other molecular function","SPCS1","ENSG00000114902","Protein export","","",1118.2,1116.3,1098.5,926.9,1087.6,853.2,1.1622554660529345,0.21692721082475705,0.08940000270172029,1.0486624680794492,0.3063406562338835,0.5137953616449051,2133]
["Q9Y6B6","GTP-binding protein SAR1b [OS=Homo sapiens]",47,8,65,4,198,22.4,6.11,172.63,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","SAR1B","ENSG00000152700","Protein processing in endoplasmic reticulum; Legionellosis","MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Chylomicron assembly","Sterol regulatory element-binding proteins (SREBP) signaling",2165.8,2149.3,2051.1,1919.2,1980,1847.4,1.1078202763373126,0.14772384937626812,0.016985624409801264,1.7699184833687733,0.14123768920504828,0.8500493965585721,879]
["Q9Y6B7","AP-4 complex subunit beta-1 [OS=Homo sapiens]",5,5,8,5,739,83.2,5.86,15.67,"transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","other molecular function","AP4B1","ENSG00000134262","Lysosome","Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis","",540.8,585.7,539.3,516,580.7,489.9,1.0499180637841925,0.07027674352507114,0.44223068607787225,0.3543511253215021,0.6119394328934434,0.21329156030843435,5282]
["Q9Y6C2","EMILIN-1 [OS=Homo sapiens]",4,3,3,3,1016,106.6,5.15,9.3,"","","","","","","","",337.4,281.3,348.7,477.6,481,684.7,0.5886934826264224,-0.7644114390977295,0.0345886854882724,1.4610659426412484,0.19327882433775456,0.7138157247455239,1308]
["Q9Y6C9","Mitochondrial carrier homolog 2 [OS=Homo sapiens]",45,12,36,12,303,33.3,7.97,143.4,"other biological processes","other membranes;mitochondrion","","MTCH2","ENSG00000109919; ENSG00000285121","","","",4911.2,5467.5,4811.4,5305.7,4488.1,6752.8,0.9180194118429165,-0.12340343463235716,0.549621658525318,0.2599361616968716,0.6875209142840234,0.1627140861231662,5843]
["Q9Y6D0","selenoprotein K [OS=Homo sapiens]",10,1,2,1,94,10.6,10.86,4.11,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi","other molecular function","SELENOK","ENSG00000113811","","","Selenium micronutrient network",101.4,109.7,78.5,154.8,207.7,57.5,0.6895238095238096,-0.5363277254702794,0.38844144102119377,0.4106744434222356,0.5802408527332731,0.23639169729820086,4893]
["Q9Y6D5","Brefeldin A-inhibited guanine nucleotide-exchange protein 2 [OS=Homo sapiens]",29,43,115,33,1785,201.9,6.33,337.73,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","ARFGEF2","ENSG00000124198","Endocytosis","Association of TriC/CCT with target proteins during biosynthesis","",9562.6,9608.7,10177,9717.7,9331.1,9292.4,1.035534839738614,0.05037609269177447,0.23400054028590636,0.630783139842349,0.47246131186455514,0.3256337484915418,3620]
["Q9Y6D6","Brefeldin A-inhibited guanine nucleotide-exchange protein 1 [OS=Homo sapiens]",21,30,54,20,1849,208.6,5.85,148.05,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","ARFGEF1","ENSG00000066777","Endocytosis","","",2106.4,2079.6,2114.2,2356.2,2376,1933.4,0.9451812289966394,-0.08133711676304178,0.4473907904335578,0.34931296012551555,0.6151202572006911,0.21103997051223697,5316]
["Q9Y6D9","mitotic spindle assembly checkpoint protein MAD1 [OS=Homo sapiens]",30,21,46,21,718,83,5.92,141.24,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","MAD1L1","ENSG00000002822","Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection; Viral carcinogenesis","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; Malignant pleural mesothelioma; CCL18 signaling pathway",5071.1,4908.9,5037.3,5338.1,5330,5061.8,0.9546977412443817,-0.0668840488911041,0.08309859535391313,1.0804063171930287,0.29541227307478163,0.5295714656322938,2056]
["Q9Y6E0","Serine/threonine-protein kinase 24 [OS=Homo sapiens]",44,16,82,9,443,49.3,5.69,238.94,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","STK24","ENSG00000102572","","Apoptotic cleavage of cellular proteins","",3734.8,3936.4,3805.8,4121.6,3869.7,5162.4,0.8725301626158419,-0.19672308997866464,0.23489872647957324,0.6291193377749409,0.47296826221465593,0.32516800092708037,3630]
["Q9Y6E2","Basic leucine zipper and W2 domain-containing protein 2 [OS=Homo sapiens]",43,20,98,16,419,48.1,6.68,245.56,"developmental processes;other biological processes","other cell component","","BZW2","ENSG00000136261","","","",8027.4,7757.4,8186.8,7724.9,7336.2,6070.7,1.134385144663493,0.18191054500614715,0.1398381467258434,0.8543743403738103,0.37617851101184746,0.42460601690772815,2717]
["Q9Y6G1","Transmembrane protein 14A [OS=Homo sapiens]",6,1,1,1,99,10.7,10.55,0,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion;ER/Golgi","","TMEM14A","ENSG00000096092","","","",21.7,66.3,70.4,46.5,23.5,35.4,1.5028462998102468,0.5876974684423951,0.3561315261023168,0.44838957924279854,0.5629250268775592,0.2495494427712982,4624]
["Q9Y6G5","COMM domain-containing protein 10 [OS=Homo sapiens]",29,4,8,4,202,23,6.54,19.29,"","nucleus;other cell component","","COMMD10","ENSG00000145781","","Neddylation","",272.8,291.1,301.6,284.1,293,230.9,1.071163366336634,0.0991785266148444,0.4157686022376826,0.38114831055476245,0.5952698753683099,0.22528609509371852,5105]
["Q9Y6G9","Cytoplasmic dynein 1 light intermediate chain 1 [OS=Homo sapiens]",54,23,68,23,523,56.5,6.42,245.49,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","DYNC1LI1","ENSG00000144635","Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection","Neutrophil degranulation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; MHC class II antigen presentation; COPI-mediated anterograde transport; HCMV Early Events; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy","Ciliary landscape; Intraflagellar transport proteins binding to dynein",9476.2,9209.1,9265.3,8953,9569,7860.4,1.0594411425799017,0.08330344078536561,0.36007076898998985,0.443612133784579,0.5646336087852041,0.2482332748331916,4661]
["Q9Y6H1","Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 [OS=Homo sapiens]",15,2,2,2,151,15.5,9.22,5.96,"cell organization and biogenesis;stress response;other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","CHCHD2","ENSG00000106153","","Mitochondrial protein import","",177.8,182.1,160.9,306.1,312.3,373.5,0.5250529287226534,-0.9294652318099874,2.2019337996292275E-3,2.6571957420799386,0.054188330442727355,1.2660942295131778,297]
["Q9Y6H3","Mitochondrial inner membrane protease ATP23 homolog [OS=Homo sapiens]",14,2,2,2,246,28.1,8.03,7.23,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component","kinase activity;other molecular function","ATP23","ENSG00000166896; ENSG00000262145","","","",43.1,45.6,54.3,55.8,46.9,68.5,0.8352803738317757,-0.2596675547353952,0.25766466165279656,0.5889451402444728,0.4941671508843585,0.30612612713266696,3811]
["Q9Y6I3","epsin-1 [OS=Homo sapiens]",20,10,24,9,576,60.3,4.83,78.69,"transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","EPN1","ENSG00000063245","Endocytosis","Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation","VEGFA-VEGFR2 signaling pathway; EGF/EGFR signaling pathway",2722.9,2658.8,2628.7,2795.7,2836.8,2571.1,0.9764493636939882,-0.03438286351642083,0.5008109397420796,0.30032619294114327,0.6555206229539505,0.18341364067227497,5584]
["Q9Y6I4-1","Ubiquitin carboxyl-terminal hydrolase 3 [OS=Homo sapiens]",10,4,6,4,520,58.9,8.18,22.19,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","USP3","ENSG00000140455","","Ub-specific processing proteases","",423.9,479.7,445,496.4,427.7,1107.7,0.663746431735407,-0.5912958947995283,0.3526729180301008,0.452627888792003,0.5614651182491847,0.2506772196740508,4591]
["Q9Y6I9","Testis-expressed protein 264 [OS=Homo sapiens]",52,11,32,11,313,34.2,4.86,102.42,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","TEX264","ENSG00000164081","","Platelet degranulation","",2742.7,2816.6,2737.8,2572,3068.2,3293,0.9287937133390047,-0.1065698877197748,0.37889254895663377,0.4214839351811592,0.5739535005852925,0.24112329097699758,4825]
["Q9Y6J0","Calcineurin-binding protein cabin-1 [OS=Homo sapiens]",5,9,12,9,2220,246.2,6.02,36.69,"cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity","CABIN1","ENSG00000099991","","Formation of Senescence-Associated Heterochromatin Foci (SAHF)","",1139,1143.6,1122.3,1293.8,1297.2,1434.8,0.8457697848874756,-0.24166307385812344,0.011567720535327558,1.936752212047401,0.11710314320319823,0.9314314477330672,722]
["Q9Y6J9","TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L [OS=Homo sapiens]",13,6,8,6,622,67.8,8.97,15.23,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","TAF6L","ENSG00000162227","Basal transcription factors","HATs acetylate histones","",616.2,678.5,670.6,761.6,817,1088.5,0.7368677589891643,-0.44052236372015474,0.08538158215751322,1.0686358017935955,0.2994500882865951,0.5236755545371095,2084]
["Q9Y6K0","Choline/ethanolaminephosphotransferase 1 [OS=Homo sapiens]",1,1,1,1,416,46.5,8.21,1.82,"other metabolic processes","other membranes;ER/Golgi;nucleus","other molecular function","CEPT1","ENSG00000134255","Phosphonate and phosphinate metabolism; Glycerophospholipid metabolism; Ether lipid metabolism; Metabolic pathways","Synthesis of PC; Synthesis of PE","Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways",87.3,83.5,83.8,73.6,76.1,84,1.0894308943089432,0.12357468511853277,0.10705536339788266,0.9703915699785506,0.33353267309255086,0.4768616158740881,2346]
["Q9Y6K1","DNA (cytosine-5)-methyltransferase 3A [OS=Homo sapiens]",2,2,3,2,912,101.8,6.57,4.65,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DNMT3A","ENSG00000119772","Cysteine and methionine metabolism; Metabolic pathways; MicroRNAs in cancer","PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; RMTs methylate histone arginines; SUMOylation of DNA methylation proteins","One-carbon metabolism; Trans-sulfuration and one-carbon metabolism; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; One-carbon metabolism and related pathways; MTHFR deficiency",84.5,97.3,93.1,144.3,93.2,2564.1,0.09812250142775555,-3.349272176920605,0.359929804477326,0.44378218951240017,0.5646548488784665,0.24821693807664819,4659]
["Q9Y6K5","2'-5'-oligoadenylate synthase 3 [OS=Homo sapiens]",5,6,10,6,1087,121.1,8.4,24.05,"other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","OAS3","ENSG00000111331","NOD-like receptor signaling pathway; Hepatitis C; Measles; Influenza A; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease","Interferon gamma signaling; Interferon alpha/beta signaling; OAS antiviral response","Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction",752.6,747.9,764.8,778.8,717.1,1416.2,0.7778922427114452,-0.3623577747310469,0.38937961135127913,0.40962679269645114,0.580811342727857,0.23596491084099183,4900]
["Q9Y6K9","NF-kappa-B essential modulator [OS=Homo sapiens]",11,4,4,4,419,48.2,5.71,12.21,"cell organization and biogenesis;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","IKBKG","ENSG00000269335","Antifolate resistance; MAPK signaling pathway; Ras signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; TNF signaling pathway; Adipocytokine signaling pathway; Alcoholic liver disease; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Chagas disease; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Chemical carcinogenesis; Pancreatic cancer; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Primary immunodeficiency; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; TNFR1-induced NFkappaB signaling pathway; activated TAK1 mediates p38 MAPK activation; ER-Phagosome pathway; IKK complex recruitment mediated by RIP1; TICAM1, RIP1-mediated IKK complex recruitment; Regulation of TNFR1 signaling; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Ovarian tumor domain proteases; RIP-mediated NFkB activation via ZBP1; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; SUMOylation of immune response proteins","Nucleotide-binding oligomerization domain (NOD) pathway; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; ATM signaling in development and disease ; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNAs involvement in the immune response in sepsis; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Canonical NF-kB pathway; Cytosolic DNA-sensing pathway; Small cell lung cancer; Hepatitis B infection; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Network map of SARS-CoV-2 signaling pathway; T-cell receptor (TCR) signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway",348.5,267.5,308.3,501.9,591,540.5,0.5658748622505203,-0.8214450446057925,0.002458381316901594,2.6093507532712743,0.05759073411933894,1.239647385405744,312]
["Q9Y6M1","Insulin-like growth factor 2 mRNA-binding protein 2 [OS=Homo sapiens]",23,13,35,13,599,66.1,8.46,107.13,"transport;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","IGF2BP2","ENSG00000073792","","Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA","",4115.5,4096,4195,4302.3,3808.4,3281.5,1.0890346026228472,0.12304979449493732,0.31748999678198375,0.49826995355570325,0.5404132246109732,0.26727403177196024,4294]
["Q9Y6M5","zinc transporter 1 [OS=Homo sapiens]",45,15,58,15,507,55.3,6.48,185.42,"stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","SLC30A1","ENSG00000170385","Mineral absorption","Zinc efflux and compartmentalization by the SLC30 family","Zinc homeostasis",5607.2,6107,5878.5,4652.4,4872.3,6217.9,1.1175218832975493,0.16030308251887493,0.29332331300131487,0.5326534184191516,0.5237967492613268,0.28083720118044814,4093]
["Q9Y6M7-7","Isoform 7 of Sodium bicarbonate cotransporter 3 [OS=Homo sapiens]",7,8,12,8,1259,140.7,6.62,35,"","","","SLC4A7","","","","",982.3,1113,1105.5,1017.8,1068.7,1082.7,1.0099709705919477,0.014313826457353124,0.8327290991246127,0.07949625896552932,0.886715761291054,0.05221557192220534,6864]
["Q9Y6M9","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [OS=Homo sapiens]",11,1,1,1,179,21.8,8.38,3.79,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity","NDUFB9","ENSG00000147684","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial immune response to SARS-CoV-2; Oxidative phosphorylation",22.2,22.8,26.6,23.1,29.9,33.1,0.8315911730545876,-0.2660536501325877,0.2116773694744346,0.6743255701229197,0.4529127322859024,0.34398547025591414,3416]
["Q9Y6N1","Cytochrome c oxidase assembly protein COX11, mitochondrial [OS=Homo sapiens]",12,2,10,2,276,31.4,9.06,13.74,"other metabolic processes;other biological processes","other membranes;mitochondrion;other cell component","other molecular function","COX11","ENSG00000166260","Oxidative phosphorylation; Metabolic pathways; Thermogenesis","Cytoprotection by HMOX1; Respiratory electron transport; TP53 Regulates Metabolic Genes","Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis; Mitochondrial complex IV assembly",202.9,217,220.2,172.4,203.8,268.9,0.9922492636800495,-0.011225508244804092,0.9567928144217919,0.019182094924104193,0.9710078701206438,0.012777250075397746,7202]
["Q9Y6N5","Sulfide:quinone oxidoreductase, mitochondrial [OS=Homo sapiens]",71,29,161,29,450,49.9,9.11,531.19,"other metabolic processes","other membranes;mitochondrion","other molecular function","SQOR","ENSG00000137767","Sulfur metabolism; Metabolic pathways","Sulfide oxidation to sulfate","",19748.7,20064.9,20327.5,17622.6,17755.9,13034,1.2422638781306483,0.3129716592544337,0.0664709242583982,1.1773682824484935,0.2667962577729997,0.5738202663594405,1821]
["Q9Y6N7","Roundabout homolog 1 [OS=Homo sapiens]",4,7,11,6,1651,180.8,6.04,21.23,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","ROBO1","ENSG00000169855","Axon guidance","Regulation of expression of SLITs and ROBOs; Netrin-1 signaling; Regulation of cortical dendrite branching; Regulation of commissural axon pathfinding by SLIT and ROBO; Role of ABL in ROBO-SLIT signaling; Inactivation of CDC42 and RAC1; Activation of RAC1; SLIT2:ROBO1 increases RHOA activity","Development of ureteric collection system",589.2,566.2,580.9,598.1,611.8,959.3,0.8004333394799928,-0.3211468355638243,0.28980791196981703,0.5378897621432165,0.5219827571679134,0.28234384295657067,4058]
["Q9Y6P5-2","Isoform T1 of Sestrin-1 [OS=Homo sapiens]",25,13,29,13,551,63.8,6.3,95.15,"","","","SESN1","","","","",2809.2,2867,2871.4,3211.2,2917.4,3065.4,0.9296932782249294,-0.10517327003331885,0.06876985934176297,1.1626018639400575,0.2696560632666017,0.5691898100740471,1864]
["Q9Y6Q9-1","Nuclear receptor coactivator 3 [OS=Homo sapiens]",3,3,4,3,1424,155.2,7.47,12.25,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","NCOA3","ENSG00000124151","Endocrine resistance; Estrogen signaling pathway; Thyroid hormone signaling pathway; Pathways in cancer; Breast cancer","PPARA activates gene expression; Estrogen-dependent gene expression; Transcriptional regulation of white adipocyte differentiation; MAPK6/MAPK4 signaling; Activation of anterior HOX genes in hindbrain development during early embryogenesis","Androgen receptor signaling pathway; Integrated breast cancer pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Breast cancer pathway; EGF/EGFR signaling pathway",201.5,202.8,230.4,425.3,437.5,519.3,{"$f":"AVERAGE(S7298:U7298)/AVERAGE(V7298:X7298)","v":0.4592287099341582},{"$f":"LOG(Y7298,2)","v":-1.1227152560425873},{"$f":"TTEST(V7298:X7298,S7298:U7298,2,2)","v":1.2978045100067012E-3},2.8867907209557977,{"$f":"AA7298*7309/AE7298","v":0.044119317040181294},1.3553712189874298,215]
["Q9Y6R4-1","Mitogen-activated protein kinase kinase kinase 4 [OS=Homo sapiens]",4,5,7,4,1608,181.6,6.32,20.22,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","other cell component","kinase activity;other molecular function","MAP3K4","ENSG00000085511","MAPK signaling pathway; GnRH signaling pathway","","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; EGF/EGFR signaling pathway; Insulin signaling; MAP3K1 role in promoting and blocking gonadal determination; Host-pathogen interaction of human coronaviruses - MAPK signaling; Malignant pleural mesothelioma; G13 signaling pathway; DNA damage response (only ATM dependent)",132.8,144.4,132.6,122.4,128,303.8,0.7394442439552509,-0.4354867264701702,0.4651805056702269,{"$f":"-LOG10(AA7299)","v":0.33237849355073595},0.6293973187604014,{"$f":"-LOG10(AC7299)","v":0.2010751115181951},5402]
["Q9Y6R9","Coiled-coil domain-containing protein 61 [OS=Homo sapiens]",8,5,8,5,512,57.3,10.27,17.7,"cell cycle OR cell proliferation;cell organization and biogenesis","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","CCDC61","ENSG00000104983","","","",435.1,439,410.4,539.6,528.9,625.7,0.7581749498288278,-0.3993973043702949,0.01286542511468623,1.890575858741464,0.12324166731748579,0.9092424348123717,763]
["Q9Y6V0-1","Protein piccolo [OS=Homo sapiens]",0,1,6,1,5065,552.9,6.51,12.09,"","","","","","","","",480.5,654,685.5,503.2,483.7,692.5,1.0837203763248777,0.1159925576793496,0.6378948120462188,0.19525092992174783,0.752238331920912,0.1236445399410391,6198]
["Q9Y6V7","Probable ATP-dependent RNA helicase ddx49 [OS=Homo sapiens]",10,3,4,3,483,54.2,9.06,15.77,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","DDX49","ENSG00000105671","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",340,345.5,310.2,690.1,672.8,426,0.5565990273352339,-0.8452897073458704,0.03713057935570036,1.430268274339132,0.19852772824492607,0.7021788270229814,1367]
["Q9Y6W3","Calpain-7 [OS=Homo sapiens]",18,12,25,12,813,92.6,7.65,63.85,"protein metabolism;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","CAPN7","ENSG00000131375","","Degradation of the extracellular matrix","Integrin-mediated cell adhesion",2849.1,2811.8,2787.5,3159.8,3240.7,2513.4,0.9477781891203626,-0.07737863375853514,0.5382875075422161,0.2689856990779333,0.678803207837484,0.1682561139930973,5796]
["Q9Y6W5","Wiskott-Aldrich syndrome protein family member 2 [OS=Homo sapiens]",24,13,44,12,498,54.3,5.53,115.77,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","WASF2","ENSG00000158195","Adherens junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Yersinia infection; Choline metabolism in cancer","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RAC2 GTPase cycle; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway","Regulation of actin cytoskeleton",5610.4,5577.2,5784.1,5647.1,5771.9,5427.9,1.0074078910660118,0.010647936840536783,0.744826504309405,0.12794487758187253,0.8272203191000518,0.08237880649789552,6581]
["Q9Y6X3-1","MAU2 chromatid cohesion factor homolog [OS=Homo sapiens]",7,3,4,3,613,69,7.25,16.13,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MAU2","ENSANAG00000026794; ENSCANG00000033671; ENSCATG00000015302; ENSCCAG00000031923; ENSCSAG00000005122; ENSG00000129933; ENSGGOG00000002989; ENSMFAG00000041829; ENSMNEG00000034232; ENSPPAG00000032359; ENSPTRG00000010738; ENSRBIG00000036077; ENSRROG00000032649; ENSSBOG00000034577","","Cohesin Loading onto Chromatin","Cohesin complex - Cornelia de Lange syndrome",401.5,349.2,420,333.8,303.7,285.3,1.2686389250108367,0.34328151344972563,0.03158569394276659,1.5005095771453096,0.1867798034204539,0.7286700860141337,1236]
["Q9Y6X4-1","Soluble lamin-associated protein of 75 kDa [OS=Homo sapiens]",6,4,6,4,670,74.9,4.6,19.28,"","other membranes;nucleus","","FAM169A","ENSG00000198780","","RHOF GTPase cycle","",463,463.2,615.8,482.1,513.4,352,1.1443413729128014,0.19451749227516632,0.41247855306332704,0.3845986277889556,0.59323214174338,0.2267753266193332,5082]
["Q9Y6X5","Bis(5'-adenosyl)-triphosphatase ENPP4 [OS=Homo sapiens]",11,5,11,5,453,51.6,6.15,29.68,"other metabolic processes;stress response;other biological processes","plasma membrane;other membranes","other molecular function","ENPP4","ENSG00000001561","Purine metabolism; Metabolic pathways","Neutrophil degranulation","",889.4,894,902.1,854.5,909,930,0.9970298867644328,-4.2913436835616305E-3,0.9125411344203169,0.03974754983135853,0.941657934699717,0.02610682974577504,7083]
["Q9Y6X9-1","MORC family CW-type zinc finger protein 2 [OS=Homo sapiens]",12,12,19,12,1032,117.8,8.38,55.94,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","MORC2","ENSG00000133422","","Fatty acyl-CoA biosynthesis","",2721.4,2587.3,2628.4,2921,2816.5,2971.2,0.9113989458817046,-0.1338453929372662,0.013080476061133783,1.8833764496691612,0.1241625967932816,0.9060092129576701,770]
["Q9Y6Y0","influenza virus NS1A-binding protein [OS=Homo sapiens]",1,1,1,1,642,71.7,5.53,0,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","","IVNS1ABP","ENSG00000116679","","","",51.6,64.6,59.5,143.5,125.7,55.5,0.5411148752694794,-0.8859931932777122,0.1410874618406542,0.8505115794091128,0.3769036032870401,0.42376971057321844,2736]
["Q9Y6Y8","SEC23-interacting protein [OS=Homo sapiens]",29,26,73,26,1000,111,5.54,187.51,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","SEC23IP","ENSG00000107651","","COPII-mediated vesicle transport","",7325.2,7313.6,7601.4,7629.8,7327.7,8771,0.9372779568872873,-0.09345114139334364,0.3316095760655534,0.47937293658865426,0.5477365856413854,0.26142824973852546,4425]

{"sheet":"Cl-P","index":4,"n_rows":7310,"n_cols":31,"rows_kept":2250,"cut":true,"bounds":{"rows_first":1000,"rows_last":250,"rows_between":1000,"halvings":1}}
["Accession","Description","Coverage [%]","# Peptides","# PSMs","# Unique Peptides","# AAs","MW [kDa]","calc. pI","Score Sequest HT: Sequest HT","Biological Process","Cellular Component","Molecular Function","Gene Symbol","Ensembl Gene ID","KEGG Pathways","Reactome Pathways","WikiPathways","Abundances (Normalized): F7: 132C, Sample, Cl-P","Abundances (Normalized): F7: 133C, Sample, Cl-P","Abundances (Normalized): F7: 134C, Sample, Cl-P","Abundances (Normalized): F7: 126, Sample, DMSO","Abundances (Normalized): F7: 127C, Sample, DMSO","Abundances (Normalized): F7: 128C, Sample, DMSO","Ratio","log2(Ratio)","P-Value","− log10(P-Value)","q-Value","− log10(q-Value)","Rank (P-Value)"]
["A0A096LP01","Small integral membrane protein 26 [OS=Homo sapiens]",17,1,1,1,95,10.9,6.7,3.05,"","other membranes","","SMIM26","ENSG00000232388","","","",58.7,50.4,61.9,251.3,281.5,85.3,{"$f":"AVERAGE(S2:U2)/AVERAGE(V2:X2)","v":0.27665426306422913},{"$f":"LOG(Y2,2)","v":-1.8538439399328097},{"$f":"TTEST(V2:X2,S2:U2,2,2)","v":0.07123875658997893},{"$f":"-LOG10(AA2)","v":1.1472836693719544},{"$f":"AA2*7309/AE2","v":0.2648443905982482},{"$f":"-LOG10(AC2)","v":0.5770092209840981},1966]
["A0A0B4J2F0","Protein PIGBOS1 [OS=Homo sapiens]",19,1,1,1,54,6.3,8.5,3.82,"stress response;other biological processes","other membranes;mitochondrion","","PIGBOS1","ENSG00000225973","","","",62.7,47.7,62.4,42.3,98.1,55.7,0.8811830698623152,-0.18248631802868032,0.6806552820739844,{"$f":"-LOG10(AA3)","v":0.1670727808871781},0.7806228552767538,{"$f":"-LOG10(AC3)","v":0.10755873748307104},6373]
["A0A1B0GVM6","Uncharacterized protein C11orf97 [OS=Homo sapiens]",6,1,1,1,126,13.9,9.35,2.08,"","cytoskeleton;other cell component","","C11orf97","ENSG00000257057","","","",200.6,206,172.2,184.6,165.2,271.8,0.9311454311454312,-0.10292158187598531,0.6997590493279404,0.15505147650198955,0.7951708475649746,0.09953955035841143,6432]
["A0AV96","RNA-binding protein 47 [OS=Homo sapiens]",22,9,24,9,593,64.1,7.68,76.54,"RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus","nucleic acid binding activity","RBM47","ENSG00000163694","","","TYROBP causal network in microglia",1492,1484.8,1427.6,2427.4,2137.3,2465,0.6265416731866223,-0.6745176241268259,1.1543385517288824E-3,2.9376667998592554,0.03684305884098865,1.4336443203151705,229]
["A0AVK6","Transcription factor E2F8 [OS=Homo sapiens]",2,1,1,1,867,94.1,8.98,2.02,"cell cycle OR cell proliferation;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","E2F8","ENSG00000129173","","TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest","Genotoxicity pathway",65.5,69,56.8,55.7,63.9,429.8,0.3481980342191482,-1.5220200367297438,0.38819627898483405,0.4109486318124131,0.5734289820331755,0.24152036088552312,4948]
["A0AVT1-1","Ubiquitin-like modifier-activating enzyme 6 [OS=Homo sapiens]",46,38,125,37,1052,117.9,6.14,376.11,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","UBA6; UBE1L2","ENSG00000033178","Ubiquitin mediated proteolysis","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation","",12528.9,12617.4,12575.1,11917.7,11594.7,13800.7,1.0109425376074352,0.015700996187711518,0.8529005268784057,0.069101617304852,0.9046364752509457,0.04352590533556756,6891]
["A0FGR8-2","Isoform 2 of Extended synaptotagmin-2 [OS=Homo sapiens]",31,20,56,20,893,98.8,8.68,171.95,"","","","ESYT2","","","","",4532.3,4365.2,4325.3,3942.7,3944,5552,0.983934457946081,-0.023365877234860177,0.900405730334108,0.0455617497393059,0.9370732568719914,0.0282264562716197,7023]
["A0JLT2","Mediator of RNA polymerase II transcription subunit 19 [OS=Homo sapiens]",5,1,1,1,244,26.3,9.82,3.01,"other biological processes","nucleus","other molecular function","MED19","ENSG00000156603","","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","",112.8,118.1,132.1,105.2,117.4,226.6,0.8081032947462155,-0.3073883795174882,0.5023693029109171,0.29897690586262265,0.6490749929248529,0.1877051227190589,5657]
["A0JNW5-1","UHRF1-binding protein 1-like [OS=Homo sapiens]",9,10,15,10,1464,164.1,6.32,37.87,"","cytosol;other cytoplasmic organelle","other molecular function","UHRF1BP1L","ENSG00000111647","","RND2 GTPase cycle","",987.7,1017.7,910.4,1131,1203.2,1931.1,0.6836095936979816,-0.5487554511158768,0.1555855369665767,0.8080307769320958,0.3879818115621662,0.4111886334865583,2931]
["A0MZ66","Shootin-1 [OS=Homo sapiens]",37,24,49,24,631,71.6,5.33,145.6,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SHTN1","ENSG00000187164","","Recycling pathway of L1","",5400.1,5329.2,5370.8,6728.1,6456.4,8164.3,0.7541454320617552,-0.4070853301701688,0.029947625822899417,1.5236376017515991,0.17194595219133688,0.7646080435212816,1273]
["A0PJW6","Transmembrane protein 223 [OS=Homo sapiens]",4,1,1,1,202,22,11.02,3.28,"developmental processes","other membranes","","TMEM223","ENSG00000168569","","","",16.5,29.6,16.7,21.1,21,122.1,0.3824604141291109,-1.3866176628861777,0.37594099114667223,0.4248803179195252,0.56853976914774,0.2452391511744327,4833]
["A0PK00","Transmembrane protein 120B [OS=Homo sapiens]",9,2,2,2,339,40.2,8.9,9.39,"cell organization and biogenesis;transport;other biological processes","other membranes;nucleus","","TMEM120B","ENSG00000188735","","","",282.5,260.6,273,219.3,255,285.2,1.0745227123107308,0.1036959774997651,0.40049231961579435,0.3974058081202247,0.5818323124770107,0.2352021635619999,5031]
["A1A4S6","Rho GTPase-activating protein 10 [OS=Homo sapiens]",23,14,19,14,786,89.3,7.18,61.26,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","enzyme regulator activity","ARHGAP10","ENSG00000071205","Bacterial invasion of epithelial cells","Regulation of PAK-2p34 activity by PS-GAP/RHG10; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle","Ectoderm differentiation; Ectoderm differentiation",1478.9,1594.4,1604.7,1464.4,1402.6,1580.4,1.051850519404596,0.07292969489965473,0.30821927060229426,0.5111402116441882,0.5268415923368027,0.27831994629695567,4276]
["A1L0T0","Acetolactate synthase-like protein [OS=Homo sapiens]",30,13,32,13,632,67.8,8.15,108.67,"other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","ILVBL","ENSG00000105135","","","",2314.8,2322.7,2349.7,2179.6,2147.2,2475.2,1.027227286092326,0.038755430185050996,0.5877788159680739,0.23078607031165005,0.7117421083350981,0.1476773395312293,6036]
["A2AJT9-1","BCLAF1 and THRAP3 family member 3 [OS=Homo sapiens]",3,2,2,2,711,83.8,9.7,4.71,"other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","BCLAF3","ENSG00000173681","","","",129,108.8,113.9,210.3,232.3,338.7,0.45014719057980296,-1.1515312792269705,0.02336544295877375,1.6314259812680594,0.15126485614320404,0.8202619613090542,1129]
["A2RRP1-1","neuroblastoma-amplified sequence [OS=Homo sapiens]",17,31,67,31,2371,268.4,5.96,179.73,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","NBAS","ENSG00000151779","","COPI-dependent Golgi-to-ER retrograde traffic","",5011.5,5091.1,5055.3,4878.7,4713.7,6019.2,0.9709382766660691,-0.04254850962202389,0.7315967207778575,0.13572824982119908,0.8171210929348044,0.08771357860049277,6544]
["A2RTX5","Probable threonine--tRNA ligase 2, cytoplasmic [OS=Homo sapiens]",20,13,26,11,802,92.6,6.05,55.39,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","other molecular function","TARS3","ENSG00000185418","Aminoacyl-tRNA biosynthesis","","",1118.5,1120,1161.1,1143.6,1083.2,1076.6,1.0291215111703094,0.04141333520868111,0.2766702889799342,0.5580374762940746,0.503406308726497,0.2980813461417732,4017]
["A2RU49","Hydroxylysine kinase [OS=Homo sapiens]",5,1,1,1,373,41.9,6.84,3.01,"other metabolic processes","mitochondrion","kinase activity","HYKK","ENSG00000188266","Lysine degradation; Metabolic pathways","Lysine catabolism","",33.9,34.9,23.9,35.9,27.7,126.8,0.4868697478991596,-1.038392234682413,0.3656758128689057,0.43690376453195084,0.5622054093939487,0.2501049800401393,4754]
["A2RU67","Protein FAM234B [OS=Homo sapiens]",6,3,6,3,622,67,5.02,18.88,"","other membranes;cytoskeleton;ER/Golgi","","FAM234B","ENSG00000084444","","","",404.6,428.2,419.2,474,475.7,618.1,0.7985712463324403,-0.32450696822119646,0.09454194478402457,1.0243754682454673,0.3049457521740669,0.5157774118888729,2266]
["A2RUC4","tRNA wybutosine-synthesizing protein 5 [OS=Homo sapiens]",7,2,4,2,315,36.5,7.55,10.06,"RNA metabolism OR transcription;other metabolic processes","other cell component","nucleic acid binding activity;other molecular function","TYW5","ENSG00000162971","","Synthesis of wybutosine at G37 of tRNA(Phe)","",252.7,228.6,269.7,249.7,247.3,250.2,1.005085653104925,0.007318452691972185,0.920733577055405,0.03586601882963198,0.950380132000841,0.022102651332359773,7081]
["A2RUR9","Coiled-coil domain-containing protein 144A [OS=Homo sapiens]",2,3,7,2,1427,165,5.36,13.7,"","","","CCDC144A","ENSG00000170160","","","",124.9,138.4,138.8,107,121.1,198.6,0.942348254042653,-0.0856677744007508,0.7902701824971867,0.10222440401703448,0.8597923137648017,0.06560644163870699,6718]
["A2RUS2","DENN domain-containing protein 3 [OS=Homo sapiens]",9,7,10,7,1198,135.8,7.06,23.16,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol;other cell component","enzyme regulator activity","DENND3","ENSG00000105339","","RAB GEFs exchange GTP for GDP on RABs","",731.2,722.6,696.6,735.7,702.1,775.8,0.9714492229851824,-0.04178950583119444,0.42440082939646695,0.3722237760384704,0.5949262873146868,0.22553684098680757,5214]
["A3KMH1","von Willebrand factor A domain-containing protein 8 [OS=Homo sapiens]",14,19,30,19,1905,214.7,7.4,99.05,"","mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","VWA8","ENSG00000102763","","","",3205.5,3113,3093.1,2826.6,2908.5,3020.7,1.074898924141712,0.10420100540049711,0.02968295690904091,1.527492838389113,0.17096353983308116,0.7670964985998449,1269]
["A3KN83-1","protein strawberry notch homolog 1 [OS=Homo sapiens]",6,5,8,5,1393,154.2,7.88,19.95,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","SBNO1","ENSG00000139697","","","",127.6,119.2,124.9,119.2,118,125.7,1.024249104436484,0.03456663138242385,0.44217901967624834,0.35440186748998936,0.6070410320837151,0.21678195240865392,5324]
["A4D1E9-1","GTP-binding protein 10 [OS=Homo sapiens]",26,8,19,8,387,42.9,9.03,60.89,"other biological processes","mitochondrion;nucleus;other cell component","other molecular function","GTPBP10","ENSG00000105793","","","",1635.6,1651.1,1752.7,1626,1598.6,2402.9,0.8954953354064861,-0.15924217758785933,0.5023296565734272,0.2990111811755329,0.6491385183690205,0.18766262008040288,5656]
["A4D1P6-1","WD repeat-containing protein 91 [OS=Homo sapiens]",18,10,19,10,747,83.3,6.58,71.16,"transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle","enzyme regulator activity","WDR91","ENSG00000105875","","CDC42 GTPase cycle","",1878.8,1890.8,1919.4,1910,1861.6,1666.9,1.0460604946216787,0.06496628635258216,0.329438263996156,0.4822259592729006,0.5413363919846906,0.2665327759629287,4448]
["A5A3E0","POTE ankyrin domain family member F [OS=Homo sapiens]",13,11,339,2,1075,121.4,6.2,1022.65,"","other cell component","","POTEF","ENSG00000196604","","","",564.3,552.9,539,364.9,434.4,225.5,1.616120218579235,0.692534520055746,0.02721028454295004,1.5652669166992228,0.16355260668126795,0.7863425297519661,1216]
["A5LHX3","proteasome subunit beta type-11 [OS=Homo sapiens]",5,1,1,1,300,32.5,6.46,2.88,"protein metabolism;other metabolic processes;developmental processes","cytosol;nucleus;other cell component","other molecular function","PSMB11","ENSG00000222028","Proteasome","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling","",27.4,35.4,32.9,33.2,26.9,108.3,0.5682897862232779,-0.8153013085803708,0.4082151427671641,0.3891108891391981,0.5867540763982699,0.2315438845139885,5085]
["A5PLN9-1","Trafficking protein particle complex subunit 13 [OS=Homo sapiens]",4,2,4,2,417,46.5,5.6,9.61,"","cytosol;ER/Golgi","","C5orf44; TRAPPC13","ENSG00000113597","","RAB GEFs exchange GTP for GDP on RABs","",449.4,456.9,471.9,481.4,491.6,621,0.864617314930991,-0.2098663667787544,0.18838061885235552,0.7249637807281165,0.42235397030425353,0.3743234189120826,3260]
["A5YKK6","CCR4-NOT transcription complex subunit 1 [OS=Homo sapiens]",19,40,103,40,2376,266.8,7.11,284.22,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","CNOT1","ENSG00000125107","RNA degradation","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","Ciliary landscape",8556,8513.4,8458.4,9575.5,9325.3,14309,0.7686827382278726,-0.37953982365611133,0.189412899317832,0.7225904481849397,0.4237584576412715,0.37288162077640413,3267]
["A6NC62","Putative RBAK downstream neighbor protein [OS=Homo sapiens]",6,1,1,1,111,12.3,8.76,2.34,"","","","RBAKDN","","","","",163.6,167.8,158.5,161.9,173.2,181.8,0.9477655252466625,-0.07739791066325374,0.2298826769080347,0.6384937542927372,0.46121671301697115,0.33609496365068015,3643]
["A6NC98","Coiled-coil domain-containing protein 88B [OS=Homo sapiens]",41,50,114,50,1476,164.7,5.11,346.24,"cell organization and biogenesis;stress response;transport;other biological processes","cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","CCDC88B","ENSG00000168071","","","",8305.5,8157,8191.4,9566.4,9578.2,10639.8,0.8277453969191927,-0.27274101205012946,0.00885241621523001,2.052938174983347,0.09788549185645407,1.0092816725850142,661]
["A6ND36-1","Protein FAM83G [OS=Homo sapiens]",3,2,2,2,823,90.8,6.39,5.4,"signal transduction","cytosol;nucleus","other molecular function","FAM83G","ENSG00000188522","","","",55.2,58.7,65.3,76.3,65,124.5,0.6741911211437169,-0.5687704672185707,0.1933592139261337,0.7136351281581038,0.42748411814461923,0.3690800155095595,3306]
["A6NDG6","glycerol-3-phosphate phosphatase [OS=Homo sapiens]",38,10,26,10,321,34,6.14,84.02,"protein metabolism;other metabolic processes;other biological processes","other cell component","other molecular function","PGP","ENSG00000184207","Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism","Glycolysis","",3407.1,3483.5,3502.3,3260.2,3459.1,3532.5,1.013763436664781,0.019721036396854824,0.6150884546248165,0.21106242472359626,0.7312429269441744,0.13593832166733086,6148]
["A6NDU8","UPF0600 protein C5orf51 [OS=Homo sapiens]",42,8,16,8,294,33.6,5.26,52.53,"","cytosol;nucleus","","C5orf51","ENSG00000205765","","","",1357,1495.4,1526.5,1512.7,1549.9,888.6,1.1082455962745492,0.1482776298205772,0.5535521368876692,0.2568414683782688,0.6867955471926624,0.16317252923028916,5891]
["A6NED2","RCC1 domain-containing protein 1 [OS=Homo sapiens]",7,1,2,1,376,40.1,5.27,8.95,"cell organization and biogenesis","plasma membrane;other membranes;cytosol;other cell component","","RCCD1","ENSG00000166965","","","",16.6,15.1,10.9,10.1,13.5,17.5,1.0364963503649636,0.051715036544155435,0.863862754523601,0.06355525021515675,0.9109757427229837,0.04049318717827753,6931]
["A6NEE1","Pleckstrin homology domain-containing family D member 1 [OS=Homo sapiens]",1,1,3,1,506,59.2,6.44,6.54,"","","","PLEKHD1","ENSG00000175985","","","",467.1,488,460.4,566.3,547.1,640.4,0.8071045729273577,-0.30917248573409956,0.019017878106008693,1.720837940514207,0.13900167107681752,0.856979978630234,1000]
["A6NF36","Coiled-coil domain-containing protein 182 [OS=Homo sapiens]",5,1,1,1,153,17.5,6.58,2.1,"developmental processes","","","CCDC182","ENSG00000166329","","","",389.5,343.6,310.5,299.4,278.1,163,1.4093180283592166,0.4949972086412419,0.10390641548180052,0.9833576370209874,0.31936584977143817,0.4957115254196872,2378]
["A6NFI3","Zinc finger protein 316 [OS=Homo sapiens]",1,1,1,1,1004,108.4,5.31,1.81,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF316","ENSG00000205903","Herpes simplex virus 1 infection","","",95.9,100.8,87.2,130.7,138,329.6,0.4745111148253385,-1.075486213930564,0.18345947184277822,0.7364598611069413,0.416818551351839,0.38005296012493817,3217]
["A6NFQ2","TRPM8 channel-associated factor 2 [OS=Homo sapiens]",10,7,10,7,919,100.8,7.17,35.62,"other biological processes","plasma membrane;other membranes;other cell component","other molecular function","TCAF2","ENSG00000170379","","","",789,800.1,804.4,721.7,739.8,932.8,0.9996658731153155,-4.8212374930131321E-4,0.9970461481561268,1.284739957420962E-3,0.998548958190344,6.3063710207751146E-4,7298]
["A6NHR9-1","structural maintenance of chromosomes flexible hinge domain-containing protein 1 [OS=Homo sapiens]",19,35,74,35,2005,226.2,7.3,199.26,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SMCHD1","ENSG00000101596","","","",9141.4,8924.4,8909.6,9475,9740.7,10286.6,0.9143490507519754,-0.1291830787751735,0.02819445951356127,1.5498362264002512,0.16618814885856398,0.7793999496785134,1240]
["A6NI79","Coiled-coil domain-containing protein 69 [OS=Homo sapiens]",15,5,6,5,296,34.8,5.76,11.39,"cell cycle OR cell proliferation;cell organization and biogenesis","cytoskeleton;nucleus;other cell component","cytoskeletal activity","CCDC69","ENSG00000198624","","","",517.5,560.8,554.6,518.2,518.1,400.8,1.1362466077517224,0.18427598728004418,0.18993094490666543,0.7214042711379539,0.4242681162355799,0.3723596042532664,3272]
["A6NIH7","Protein unc-119 homolog B [OS=Homo sapiens]",35,5,10,5,251,28.1,5.68,36.45,"cell organization and biogenesis;transport;developmental processes","cytosol;other cell component","other molecular function","UNC119B","ENSG00000175970","","Trafficking of myristoylated proteins to the cilium","",861.2,852.6,848,801.2,836.9,1088.4,0.939592884650651,-0.08989230673743165,0.5766625462256267,0.2390782547547974,0.7047026501192285,0.1519940952829315,5981]
["A6NJ78","Probable methyltransferase-like protein 15 [OS=Homo sapiens]",16,4,5,4,407,46.1,8.62,15.12,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","other molecular function","METTL15","ENSG00000169519","","","",173.1,172.7,158,170.3,160.6,214.8,0.923217885284955,-0.11525692163840157,0.46739005209490353,0.33032053534615885,0.6239550485409406,0.20484669697434182,5475]
["A6NK58","Putative lipoyltransferase 2, mitochondrial [OS=Homo sapiens]",4,1,1,1,231,25.2,8.27,2.54,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","other molecular function","LIPT2","ENSG00000175536","Lipoic acid metabolism; Metabolic pathways; Biosynthesis of cofactors","Glyoxylate metabolism and glycine degradation","",82.4,83.4,87.5,78.9,84.2,198.5,0.7004977876106194,-0.5135476007026868,0.40751052448732417,0.3898611705614358,0.586317799897215,0.23186692096138214,5080]
["A6NK97-2","Isoform 2 of Solute carrier family 22 member 20 [OS=Homo sapiens]",5,1,1,1,347,37,7.78,0,"","","","SLC22A20P","","","","",25.3,24.8,26.9,25,16.6,38.5,0.9612983770287141,-0.05694379682644639,0.8797496749101121,0.055640884975601636,0.9214804204525665,0.03551388820372075,6978]
["A6NKF1","SAC3 domain-containing protein 1 [OS=Homo sapiens]",7,2,2,2,404,43.5,8.69,6.58,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;nucleus;other cell component","","SAC3D1","","","","",191.8,174.7,164.8,223.8,183.7,237.9,0.8232104121475055,-0.2806668650138716,0.10281327190144117,0.9879508197617562,0.3176087085070302,0.4981075981696948,2366]
["A7E2V4","Zinc finger SWIM domain-containing protein 8 [OS=Homo sapiens]",6,6,7,6,1837,197.2,6.8,22.41,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","other molecular function","ZSWIM8","ENSG00000214655","","Regulation of expression of SLITs and ROBOs","",532.8,501.3,493.3,590.7,586.6,896.1,0.7366644159351788,-0.4409205389652407,0.15257104598929927,0.8165278763428911,0.3841342663230411,0.415516950290592,2903]
["A8MVU1","Putative neutrophil cytosol factor 1C [OS=Homo sapiens]",33,8,20,8,366,41.8,8.84,66.73,"other metabolic processes","other cell component","enzyme regulator activity;other molecular function","NCF1C","","","","",1291.8,1329.7,1375.1,1575.4,1490.5,2348.5,0.738142730496454,-0.4380282858243595,0.15966228817263578,0.7967976510036591,0.3910762949912181,0.4077385079203173,2984]
["A8MW92","PHD finger protein 20-like protein 1 [OS=Homo sapiens]",1,1,1,1,1017,114.9,6.83,2.6,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","PHF20L1","ENSG00000129292","","","",50.4,64.3,50.7,77.4,78,64.2,0.7531876138433514,-0.4089188198339242,0.04824511040976617,1.3165466953701788,0.2176688345586302,0.6622037480288369,1620]
["A8MXV4","nucleoside diphosphate-linked moiety X motif 19 [OS=Homo sapiens]",12,2,13,2,375,42.2,7.64,35.47,"other metabolic processes","cytosol;other cytoplasmic organelle","other molecular function","NUDT19","ENSG00000213965","Peroxisome","Peroxisomal lipid metabolism; Peroxisomal protein import","",1083.7,1137.3,1079.7,968.4,908.5,307.5,1.5110327778795092,0.5955349563143341,0.15384406812278997,0.8129192445007272,0.38561258364522355,0.4138488022626913,2916]
["A9UHW6","MIF4G domain-containing protein [OS=Homo sapiens]",18,4,6,4,222,25.4,5.33,20.28,"other biological processes","cytosol;ER/Golgi;nucleus","nucleic acid binding activity;other molecular function","MIF4GD","ENSG00000125457","","","",476.4,436.5,426.6,574.4,609.8,916,0.6377964003428246,-0.6488321396963902,0.08154537606303205,1.0886006600957312,0.28422277236275695,0.546341128677102,2097]
["B2RTY4","unconventional myosin-IXa [OS=Homo sapiens]",1,3,4,3,2548,292.5,8.88,9.32,"cell organization and biogenesis;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","MYO9A","ENSG00000066933","","RHOA GTPase cycle; RHOB GTPase cycle; RHOV GTPase cycle","",182.5,204.7,203.6,203.7,199,631.4,0.571318054346775,-0.8076339733236364,0.36143939792856405,0.4419645098536594,0.5596950337838718,0.25204854660377424,4720]
["B5ME19","eukaryotic translation initiation factor 3 subunit C-like protein [OS=Homo sapiens]",44,41,177,1,914,105.4,5.64,520.95,"cell organization and biogenesis;protein metabolism;other metabolic processes","translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3CL","ENSG00000205609","","","",616.1,571.2,543,681.2,692.4,1038.4,0.7173714759535657,-0.47920771273446294,0.12920017921337051,0.8887368839313069,0.3542100937248781,0.45073906712517436,2666]
["B7ZC32","Kinesin-like protein KIF28P [OS=Homo sapiens]",1,1,1,1,967,108.2,8.43,1.83,"cell organization and biogenesis;transport;other biological processes","other membranes;cytoskeleton;mitochondrion","cytoskeletal activity;other molecular function","KIF28P","","","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",83.7,78.4,83.5,74.7,69.1,108,0.9753772835583797,-0.035967722348837064,0.8743628316900498,0.05830831210020899,0.9178109919320083,0.037246745391816174,6963]
["B9A064-1","Immunoglobulin lambda-like polypeptide 5 [OS=Homo sapiens]",48,8,196,8,214,23,8.84,691.91,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","IGLL5","ENSG00000254709","","","",31765.9,29219.2,28836.7,42363.8,37975.4,53210.2,0.6725735944901287,-0.572235955698674,0.03435221437902262,1.4640452626337217,0.1830031595453909,0.7375414121204817,1372]
["C9J798","Ras GTPase-activating protein 4B [OS=Homo sapiens]",17,12,17,12,803,90.4,7.74,47.22,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol","enzyme regulator activity;other molecular function","RASA4B","ENSG00000170667","","","Ras signaling",1799.6,1785.1,1819.2,1996.9,2038.5,2414.6,0.8378139534883721,-0.2552981829187313,0.058944242221192274,1.2295586111573633,0.2398794356317897,0.620006981604676,1796]
["C9JI98","Transmembrane protein 238 [OS=Homo sapiens]",6,1,1,1,176,18,11.53,2.83,"","other membranes","","TMEM238","ENSG00000233493","","","",166.9,150,154.1,141.9,164.1,152,1.0283842794759825,0.040379461515839266,0.6247571402532185,0.20428877168834414,0.7384136381162313,0.13170029071463965,6184]
["C9JRZ8","Aldo-keto reductase family 1 member B15 [OS=Homo sapiens]",5,2,7,1,316,36.5,6.7,14.99,"other metabolic processes","cytosol;mitochondrion","other molecular function","AKR1B15","ENSG00000227471","","Estrogen biosynthesis","",477.5,599.9,630.6,428.9,324.6,145.3,1.9003115264797512,0.9262359453279458,0.047054489305506146,1.3273989357308835,0.21508521721947743,0.6673894375931453,1599]
["L0R6Q1","SLC35A4 upstream open reading frame protein [OS=Homo sapiens]",47,5,18,5,103,11.1,8.1,62.31,"stress response","other membranes","","SLC35A4","ENSG00000176087","","","",2192.5,2234.3,2523.9,1898.8,2251.4,1431.4,1.2452880894367206,0.31647953917838856,0.15326636960188794,0.8145531295462056,0.38469227177891446,0.4148865383032322,2912]
["O00115","Deoxyribonuclease-2-alpha [OS=Homo sapiens]",10,4,11,4,360,39.6,8.05,21.95,"cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes","other cytoplasmic organelle","nucleic acid binding activity;other molecular function","DNASE2","ENSG00000105612","Lysosome","Lysosome Vesicle Biogenesis","",1336.6,1483,1350.3,1199.4,1293.7,1838.2,0.9627363609078105,-0.054787315390207564,0.8054716671279867,0.09394973150346367,0.8708864519287655,0.060038465561126644,6760]
["O00116","Alkyldihydroxyacetonephosphate synthase, peroxisomal [OS=Homo sapiens]",36,17,47,17,658,72.9,7.34,166.8,"other metabolic processes","cytosol;nucleus;other cytoplasmic organelle","other molecular function","AGPS","ENSG00000018510","Ether lipid metabolism; Metabolic pathways; Peroxisome","Plasmalogen biosynthesis; TYSND1 cleaves peroxisomal proteins","Triacylglyceride synthesis",4525.2,4647.8,4505.9,4356.3,4094.6,5517,0.979309702961791,-0.03016291609089295,0.8371781811377388,0.07718209893698409,0.8940583468637834,0.04863413792207375,6844]
["O00124-1","UBX domain-containing protein 8 [OS=Homo sapiens]",8,1,1,1,270,30.5,7.78,3.78,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","UBXN8","ENSG00000104691; ENSPTRG00000049759","Protein processing in endoplasmic reticulum","","",16.6,9.5,10.3,20.3,12.5,31.2,0.5687500000000001,-0.8141334546886659,0.19207380019573994,0.7165318709863987,0.42618925489698334,0.37039750393616133,3294]
["O00139","Kinesin-like protein KIF2A [OS=Homo sapiens]",38,19,40,1,706,79.9,6.68,110.76,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KIF2A","ENSG00000068796","","COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Kinesins; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",3591.6,3549.9,3565.1,3818.6,3718.5,4630,0.8799631793936106,-0.18448493706652216,0.16719707574101875,0.7767713225946408,0.39896945040519294,0.39906035751724056,3063]
["O00139-2","Isoform 2 of Kinesin-like protein KIF2A [OS=Homo sapiens]",39,19,42,1,660,75,6.4,112.68,"","","","KIF2A","","","","",174.6,162.8,162,167.5,193,471.5,{"$f":"AVERAGE(S66:U66)/AVERAGE(V66:X66)","v":0.6002403846153846},{"$f":"LOG(Y66,2)","v":-0.7363877071002423},{"$f":"TTEST(V66:X66,S66:U66,2,2)","v":0.31876471452315364},0.49652975859340026,{"$f":"AA66*7309/AE66","v":0.5349830765671021},0.27165995605310933,4355]
["O00142","thymidine kinase 2, mitochondrial [OS=Homo sapiens]",15,3,5,3,265,31,8.46,13.08,"DNA metabolism;other metabolic processes","mitochondrion;other cell component","kinase activity;other molecular function","TK2","ENSG00000166548","Pyrimidine metabolism; Drug metabolism; Metabolic pathways","Pyrimidine salvage","Pyrimidine metabolism",516.3,517.1,501.6,454.1,439.1,490.1,1.1096652931395936,0.15012458401182027,0.03384431957113262,{"$f":"-LOG10(AA67)","v":1.4705142128260797},0.18215620894359963,{"$f":"-LOG10(AC67)","v":0.7395560208865898},1358]
["O00148","ATP-dependent RNA helicase DDX39A [OS=Homo sapiens]",56,22,194,9,427,49.1,5.68,472.72,"RNA metabolism OR transcription;other metabolic processes;transport","nucleus;other cell component","other molecular function","DDX39A","ENSG00000123136","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","",23949.4,24423.7,24357.6,25702.3,23819.2,21174.1,1.0287867986126435,0.04094403524130134,0.6348169611083045,0.19735147823518184,0.7453617941751964,0.12763287211898283,6225]
["O00151","PDZ and LIM domain protein 1 [OS=Homo sapiens]",73,16,96,16,329,36,7.02,326.94,"cell organization and biogenesis;stress response;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","PDLIM1","ENSG00000107438","","","",11696.2,11580.1,11062.5,12502.6,13141.8,10253.8,0.956560496069441,-0.06407188259463469,0.593407402677627,0.22664704022006732,0.7154758670687521,0.1454050103676979,6062]
["O00154","cytosolic acyl coenzyme A thioester hydrolase [OS=Homo sapiens]",39,14,70,14,380,41.8,8.54,221.44,"other metabolic processes","cytosol;mitochondrion;nucleus","other molecular function","ACOT7","ENSG00000097021","Fatty acid elongation; Biosynthesis of unsaturated fatty acids","Mitochondrial Fatty Acid Beta-Oxidation","",6155.2,6323,6085.6,5621.5,5603.7,6431.7,1.0513623569256212,0.0722599865613903,0.3441343110292594,0.4632720250023958,0.5484687482147529,0.2608481135123429,4586]
["O00159-1","Unconventional myosin-Ic [OS=Homo sapiens]",24,25,63,25,1063,121.6,9.41,176.7,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","MYO1C","ENSG00000197879","Pathogenic Escherichia coli infection","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Translocation of SLC2A4 (GLUT4) to the plasma membrane","VEGFA-VEGFR2 signaling pathway; Insulin signaling",8883.7,8993,8991.5,8970.4,8543.7,8856.5,1.018869498608299,0.026969276461927268,0.27913084266408444,0.5541921733330808,0.505242032944971,0.29650052605672833,4038]
["O00161","Synaptosomal-associated protein 23 [OS=Homo sapiens]",57,11,42,11,211,23.3,5.01,126.62,"cell-cell signaling;cell organization and biogenesis;stress response;transport","plasma membrane;other membranes;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","SNAP23","ENSG00000092531","SNARE interactions in vesicular transport; Platelet activation","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; ER-Phagosome pathway; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; trans-Golgi Network Vesicle Budding","Insulin signaling",4458.2,4373.8,4453.1,3792.4,4336.9,4031.3,1.0924707662450868,0.1275946747304257,0.07905176066976369,1.1020884528583061,0.27845268372785675,0.5552485920224447,2075]
["O00165","HCLS1-associated protein X-1 [OS=Homo sapiens]",45,10,25,10,279,31.6,4.92,86.17,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","HAX1","ENSG00000143575","","","",2435,2467.8,2569.5,2995.9,3300.3,4735.6,0.6773418662412299,-0.5620439239461676,0.0920720791761413,1.0358720494788018,0.30069473936479746,0.5218741697871602,2238]
["O00170","AH receptor-interacting protein [OS=Homo sapiens]",27,7,27,7,330,37.6,6.29,89.27,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","AIP","ENSG00000110711","Cushing syndrome; Chemical carcinogenesis","Aryl hydrocarbon receptor signalling; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","Aryl hydrocarbon receptor Netpath; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway",2568.8,2484.4,2670.2,3532,3435.6,3761.4,0.7198620561096094,-0.4742076189340132,8.2170500356009573E-4,3.085284068494402,0.031444198277595495,1.5024594738581563,191]
["O00178","GTP-binding protein 1 [OS=Homo sapiens]",34,16,39,16,669,72.4,8.34,131.59,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;other cytoplasmic organelle","nucleic acid binding activity;other molecular function","GTPBP1","ENSG00000100226","","","",3347.2,3329.9,3391.5,3173.6,3308.3,3119.7,1.0486377270454927,0.06851635602348924,0.057698084145100845,1.2388386072779711,0.2377200095921883,0.6239342608897057,1774]
["O00186","syntaxin-binding protein 3 [OS=Homo sapiens]",19,9,24,9,592,67.7,7.8,66.92,"cell adhesion;cell-cell signaling;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","STXBP3","ENSG00000116266","","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Disinhibition of SNARE formation","Insulin signaling",2243.6,2306.4,2331.9,2164.9,2140.5,2261.8,1.0479199658910952,0.06752853632080565,0.08194917978425331,1.0864553888531576,0.28454468173069236,0.5458495271408718,2105]
["O00189","AP-4 complex subunit mu-1 [OS=Homo sapiens]",7,3,3,3,453,49.9,7.2,9.07,"transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","AP4M1","ENSG00000221838","Lysosome","Lysosome Vesicle Biogenesis","",226.8,215.9,201.6,210,207.8,360.2,0.8281491002570696,-0.27203756045212296,0.43121025561099735,0.3653109187343526,0.5996415065184132,0.222108313402104,5256]
["O00193","Small acidic protein [OS=Homo sapiens]",33,6,29,6,183,20.3,4.72,110.48,"","","","SMAP","ENSG00000110696","","","",2849.5,3029.9,2753,3074.4,3436.3,3777.8,0.8390338727705691,-0.25319903977449576,0.0650640149244483,1.186659141088998,0.252015307410065,0.5985730793699562,1887]
["O00203-1","AP-3 complex subunit beta-1 [OS=Homo sapiens]",36,36,116,35,1094,121.2,6.04,322.39,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","AP3B1","ENSG00000132842","Lysosome","Golgi Associated Vesicle Biogenesis; Signaling by BRAF and RAF1 fusions","",16464,17005.7,16989.2,15594.9,15066.6,11748.1,1.1897990077718252,0.25071788027123537,0.09216755027077654,1.0354219555069784,0.3006035809589941,0.5220058501580666,2241]
["O00214-1","Galectin-8 [OS=Homo sapiens]",10,3,6,3,317,35.8,8.25,21.56,"other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;cytosol;other cell component","signal transduction activity or receptor binding;other molecular function","LGALS8","ENSG00000116977","","","",406.9,422.4,411,443.3,400.6,1220.6,0.6007750060547349,-0.7351033009948094,0.3609092419986864,0.44260199658377436,0.5598229307657892,0.25194931647884666,4712]
["O00217","NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [OS=Homo sapiens]",31,6,19,6,210,23.7,6.34,49.75,"cell organization and biogenesis;other metabolic processes;stress response;transport","other membranes;mitochondrion","transporter activity;other molecular function","NDUFS8","ENSG00000110717","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",1963.8,1775.6,1896.4,2671.5,2675.8,2494.1,0.7187236972989517,-0.47649084042398004,8.2962614565610564E-4,3.0811175696189603,0.031418329008292625,1.5028169167427612,193]
["O00221","NF-kappa-B inhibitor epsilon [OS=Homo sapiens]",22,7,15,7,500,52.8,6.68,46.7,"other biological processes","cytosol;nucleus;other cell component","","NFKBIE","ENSG00000146232","Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; Neurotrophin signaling pathway; Adipocytokine signaling pathway; Epstein-Barr virus infection; PD-L1 expression and PD-1 checkpoint pathway in cancer","Activation of NF-kappaB in B cells","TNF-alpha signaling pathway; Apoptosis; Oxidative damage response; Canonical NF-kB pathway; IL-18 signaling pathway; STING pathway in Kawasaki-like disease and COVID-19",1284.9,1301.5,1329.8,1579.3,1686.8,5556.6,0.4438777245061035,-1.171765784401732,0.2794031258390306,0.5537687394994012,0.5053594275569103,0.2963996280580763,4041]
["O00231","26S proteasome non-ATPase regulatory subunit 11 [OS=Homo sapiens]",69,27,96,26,422,47.4,6.48,321.34,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","PSMD11","ENSG00000108671","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection","Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling pathway",15249,15214.9,15556.6,17054.6,15760.9,19822.4,0.8742844984317383,-0.19382527547203804,0.14060098706985993,0.8520116304009127,0.36846633721534827,0.4336021827829895,2789]
["O00232-1","26s proteasome non-atpase regulatory subunit 12 [OS=Homo sapiens]",61,28,163,28,456,52.9,7.65,457.29,"protein metabolism;other metabolic processes","non-structural extracellular;cytosol;nucleus;other cell component","","PSMD12","ENSCANG00000030312; ENSCATG00000032968; ENSCSAG00000004164; ENSG00000197170; ENSMFAG00000032701; ENSMLEG00000034943; ENSMMUG00000002132; ENSMNEG00000032475; ENSNLEG00000001265; ENSPANG00000020562; ENSPPYG00000008565; ENSRROG00000042400","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection","Activation of NF-kappaB in B cells; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease",15237.8,15533.8,15453.1,15355.9,13956.8,11641,1.1287063195755207,0.17467015714033998,0.18126316133444564,0.7416904499298982,0.414275311505148,0.38271094745614104,3198]
["O00233-1","26S proteasome non-ATPase regulatory subunit 9 [OS=Homo sapiens]",30,6,24,6,223,24.7,6.95,72.5,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PSMD9","ENSG00000110801","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease",2268.6,2162.3,2154.8,2237.1,2323,2075.8,0.9924350879308005,-0.010955351707719352,0.8468773056779275,0.07217950504923415,0.9008624985009419,0.045341491706169613,6871]
["O00244","Copper transport protein ATOX1 [OS=Homo sapiens]",40,3,9,3,68,7.4,7.24,33.66,"stress response;transport;other biological processes","cytosol","other molecular function","ATOX1","ENSG00000177556","Mineral absorption","Detoxification of Reactive Oxygen Species; Ion influx/efflux at host-pathogen interface","Copper homeostasis",1153.5,1172,1088.8,1138.8,1217.3,991.6,1.0198942557576847,0.028419579057185892,0.7695186041994293,0.11378087602290861,0.8443794442416497,0.07346234779579465,6661]
["O00255-1","Menin [OS=Homo sapiens]",23,10,17,10,615,68,6.55,59.91,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","MEN1","ENSG00000133895","Cushing syndrome; Transcriptional misregulation in cancer","RHO GTPases activate IQGAPs; Formation of the beta-catenin:TCF transactivating complex; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",1369.7,1389.8,1356.3,1427.1,1456.8,1922,0.8564056680330429,-0.22363375080324124,0.22518068745611372,0.6474688593397825,0.456165644295104,0.3408774263257137,3608]
["O00257-1","E3 SUMO-protein ligase CBX4 [OS=Homo sapiens]",5,2,3,2,560,61.3,9.36,8.25,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","CBX4","ENSG00000141582; ENSPTRG00000040905","","SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Oxidative Stress Induced Senescence; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN gene transcription","",210.5,226.8,221.3,201.9,223.2,266,0.9529735204746057,-0.06949196722718115,0.6071669553373791,0.21669187266124293,0.7258395938110735,0.13915934516734,6114]
["O00258-1","Tail-anchored protein insertion receptor WRB [OS=Homo sapiens]",12,2,3,2,174,19.8,9.67,7.23,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;ER/Golgi;nucleus","","GET1; WRB","ENSANAG00000014374; ENSCANG00000035340; ENSCATG00000041953; ENSCCAG00000026562; ENSCSAG00000008355; ENSG00000182093; ENSMLEG00000038301; ENSMNEG00000036276; ENSNLEG00000033928; ENSPANG00000032093; ENSPPAG00000034665; ENSPPYG00000011427; ENSPTRG00000013915; ENSSBOG00000020756","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",380.1,394.2,398.3,346.9,358.3,271.4,1.2006962932623384,0.2638712787590091,0.07863226000527063,1.1043992419006583,0.2780470190510513,0.5558817566439735,2067]
["O00264","Membrane-associated progesterone receptor component 1 [OS=Homo sapiens]",61,12,49,10,195,21.7,4.7,143.13,"other metabolic processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","PGRMC1","ENSG00000101856","","Neutrophil degranulation","",3293.5,2997.4,3452.6,3056.2,3665.6,2840.3,1.018970728187323,0.027112608024283533,0.8400397304901425,0.0757001730755158,0.8968522334432444,0.04727910599340113,6846]
["O00267","Transcription elongation factor Spt5 [OS=Homo sapiens]",35,32,126,32,1087,120.9,5.06,422.29,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","SUPT5H","ENSG00000196235","","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE","Initiation of transcription and translation elongation at the HIV-1 LTR; mRNA processing",10879.5,10962.3,10848.7,10375.5,10216.4,9399.7,1.0899885301217673,0.12431295369622929,0.041645615631586023,1.3804307135185532,0.20051897539608843,0.6978445231940417,1518]
["O00268","Transcription initiation factor TFIID subunit 4 [OS=Homo sapiens]",8,6,7,6,1085,110,9.94,21.59,"RNA metabolism OR transcription;other metabolic processes;developmental processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","TAF4","ENSG00000130699","Basal transcription factors; Huntington disease","RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation","",648.5,591.9,621.4,777.7,756.3,749.8,0.8152202469568263,-0.2947382119048958,1.5692673722829643E-3,2.804303054874245,0.04279766874632905,1.3685798870190609,268]
["O00273-1","DNA fragmentation factor subunit alpha [OS=Homo sapiens]",50,11,30,3,331,36.5,4.79,101.46,"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","DFFA","ENSG00000160049","Apoptosis","Apoptosis induced DNA fragmentation","Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis",3077.6,2972.2,2963.4,3664.1,3806.5,5204,0.7111230334685117,-0.4918289085741445,0.06840790665459252,1.1648936991861671,0.25879575038220326,0.5870428593816687,1932]
["O00273-2","Isoform DFF35 of DNA fragmentation factor subunit alpha [OS=Homo sapiens]",55,9,25,1,268,29.4,4.61,92.3,"","","","DFFA","","","","",73.2,69.6,72.7,90.3,72.7,135,0.7231543624161074,-0.46762446137306335,0.2128948923399211,0.671834757796984,0.44829984676245554,0.34843140958442304,3471]
["O00287","Regulatory factor X-associated protein [OS=Homo sapiens]",7,1,1,1,272,28.2,5.54,2.31,"other biological processes","nucleus","nucleic acid binding activity","RFXAP","ENSG00000133111","Antigen processing and presentation; Tuberculosis; Primary immunodeficiency","","",17,11.6,12,12.7,11.1,3.2,1.503703703703704,0.5885203201343456,0.2546836920590422,0.593998862949681,0.4838791539536104,0.3152630873725235,3847]
["O00291","Huntingtin-interacting protein 1 [OS=Homo sapiens]",4,3,3,2,1037,116.1,5.3,7.67,"cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","HIP1","ENSG00000127946","Huntington disease; Pathways of neurodegeneration","Clathrin-mediated endocytosis; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants","",80.6,83.3,90.5,94.5,91.5,141.6,0.7765567765567765,-0.36483668635665345,0.21305390526610302,0.6715105007971366,0.44837632985601694,0.3483573222239259,3473]
["O00299","chloride intracellular channel protein 1 [OS=Homo sapiens]",86,18,273,17,241,26.9,5.17,1010.2,"other metabolic processes;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;mitochondrion;nucleus;other cell component","transporter activity","CLIC1","ENSG00000206394; ENSG00000213719; ENSG00000223639; ENSG00000226248; ENSG00000226417; ENSG00000226651; ENSG00000230685","","","VEGFA-VEGFR2 signaling pathway",28051.8,28860.8,30072.7,29428.6,30336.2,19887.3,1.0920653692746332,0.1270592162446913,0.5111388217434537,0.2914611324889616,0.6563446324882121,0.1828680620172354,5692]
["O00300","Tumor necrosis factor receptor superfamily member 11B [OS=Homo sapiens]",2,1,1,1,401,46,8.29,2.56,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","TNFRSF11B","ENSG00000164761","Cytokine-cytokine receptor interaction; Osteoclast differentiation","TNFs bind their physiological receptors","Osteoclast signaling; RANKL/RANK signaling pathway; Ectoderm differentiation; Vitamin D receptor pathway; Osteoblast signaling; IL-18 signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta; Overlap between signal transduction pathways contributing to LMNA laminopathies; Monoamine transport",151.7,207.5,238.5,149.9,131.5,138,1.4251311397234148,0.5110946813290131,0.08391691593531943,1.0761504854542099,0.28795715425880264,0.5406721270089747,2130]
["O00303","Eukaryotic translation initiation factor 3 subunit F [OS=Homo sapiens]",47,12,71,12,357,37.5,5.45,236.86,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3F","ENSG00000175390","","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","Translation factors; VEGFA-VEGFR2 signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell",6953.2,7124.1,7241.2,7458,7639.6,7674.9,0.9361510593918104,-0.09518674985276977,0.01067392971372305,1.9716756612891049,0.10790560480996096,0.9669559966996627,723]
["O00308","NEDD4-like E3 ubiquitin-protein ligase WWP2 [OS=Homo sapiens]",9,6,6,6,870,98.9,7.12,10.1,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","WWP2","ENSG00000198373","Ubiquitin mediated proteolysis","RHOQ GTPase cycle; Regulation of PTEN stability and activity; RHOJ GTPase cycle; NOTCH3 Activation and Transmission of Signal to the Nucleus; RHOU GTPase cycle","",563.9,613.3,592.1,781,766,837.9,0.7418759696423328,-0.4307500845088641,1.4265236153530518E-3,2.8457210344291783,0.0405698875665971,1.3917961958765002,257]
["O00327-1","Isoform BMAL1A of Aryl hydrocarbon receptor nuclear translocator-like protein 1 [OS=Homo sapiens]",2,1,1,1,583,64.2,6.98,2.86,"","","","ARNTL","","","","",31.3,33.3,34.8,40.7,36.4,23.8,0.9851337958374629,-0.021608417544071043,0.9276251067901765,0.032627505406115656,0.9557389209937129,0.019660727658066677,7094]
["O00330-1","Pyruvate dehydrogenase protein X component, mitochondrial [OS=Homo sapiens]",29,14,42,14,501,54.1,8.66,119.68,"other metabolic processes","mitochondrion;other cell component","other molecular function","PDHX","ENSG00000110435","Metabolic pathways","Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid","Amino acid metabolism",6308.1,6330.6,6664.7,6065,5880.9,8357.9,0.9507284350712675,-0.07289478463768254,0.6999651130534339,0.1549236051085337,0.795281363486328,0.09947919462492882,6433]
["O00391","Sulfhydryl oxidase 1 [OS=Homo sapiens]",2,1,1,1,747,82.5,8.92,2.8,"cell organization and biogenesis;other biological processes","non-structural extracellular;other membranes;ER/Golgi;other cell component","other molecular function","QSOX1","ENSG00000116260","","Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",29.6,30.6,38.7,30.1,23.5,11.5,1.5192012288786483,0.6033129775934754,0.1413731255544367,0.8496331402752345,0.3691661931680521,0.432778076857424,2799]
["O00399","Dynactin subunit 6 [OS=Homo sapiens]",22,4,9,4,190,20.7,6.32,21.9,"cell cycle OR cell proliferation;cell organization and biogenesis","cytosol;cytoskeleton;other cell component","other molecular function","DCTN6","ENSG00000104671","Vasopressin-regulated water reabsorption; Amyotrophic lateral sclerosis; Huntington disease; Pathways of neurodegeneration; Salmonella infection","MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic","",1088.5,1077.4,1107.6,1212.3,1218,2029.8,0.7339521535391583,-0.44624207827895596,0.21915960580814683,0.6592394893812437,0.45377834528378047,0.34315623288509334,3530]
["O00400","Acetyl-coenzyme A transporter 1 [OS=Homo sapiens]",23,12,40,12,549,60.9,7.33,119.98,"transport;signal transduction","plasma membrane;other membranes;ER/Golgi","transporter activity","SLC33A1","ENSG00000169359","Glycosphingolipid biosynthesis; Metabolic pathways","Transport of vitamins, nucleosides, and related molecules; Defective SLC33A1 causes spastic paraplegia 42 (SPG42)","Ganglio sphingolipid metabolism",4581.4,4536.5,4486.7,4236.2,3712.8,4514.2,1.091581616278323,0.12642000297915298,0.1829835117258878,0.7375880419038571,0.4163843359914427,0.38050561662652743,3212]
["O00401","Neural Wiskott-Aldrich syndrome protein [OS=Homo sapiens]",2,1,1,1,505,54.8,7.93,1.92,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity","WASL","ENSG00000106299","Endocytosis; Adherens junction; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection","Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RHOJ GTPase cycle; RHOV GTPase cycle; NOSTRIN mediated eNOS trafficking; Nephrin family interactions; EPHB-mediated forward signaling; DCC mediated attractive signaling","Pathogenic Escherichia coli infection; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Chemokine signaling pathway; G13 signaling pathway",135.4,159.5,143.8,144.1,145.7,92,1.1490309062336301,0.20041760361529298,0.3746720065598249,0.42634875379905834,0.5680310508080814,0.2456279233980924,4821]
["O00410","Importin-5 [OS=Homo sapiens]",59,46,321,43,1097,123.6,4.94,1059.57,"transport;other biological processes","nucleus;other cell component","enzyme regulator activity;other molecular function","IPO5","ENSG00000065150","Nucleocytoplasmic transport","vRNP Assembly","",32205.4,32223.4,32380.4,32169.4,31506.5,24107.6,1.1028177277050928,0.14119436385234374,0.3090865032979581,0.5099199586092772,0.5277069032013024,0.2776072245596137,4281]
["O00411","DNA-directed RNA polymerase, mitochondrial [OS=Homo sapiens]",19,16,52,16,1230,138.5,8.98,169.38,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","POLRMT","ENSG00000099821","","Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis","Mitochondrial gene expression",2775.3,2711.9,2808.8,3221.2,3059.9,4222.6,0.7898169216561783,-0.34040981732975556,0.11384044835323869,0.9437034024796921,0.33618579273285715,0.47342064386530675,2475]
["O00418","Eukaryotic elongation factor 2 kinase [OS=Homo sapiens]",16,11,19,11,725,82.1,5.33,36.59,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;other cell component","nucleic acid binding activity;kinase activity;other molecular function","EEF2K","ENSG00000103319","AMPK signaling pathway; Oxytocin signaling pathway","mTORC1-mediated signalling","Translation factors; AMP-activated protein kinase (AMPK) signaling; BDNF-TrkB signaling",1576.3,1597.1,1526.7,1695.3,1608.5,2592.4,0.7971405311895795,-0.3270940095950915,0.27456654199675934,0.5613523859320392,0.501325719573898,0.29988001415317134,4003]
["O00422","Histone deacetylase complex subunit SAP18 [OS=Homo sapiens]",52,8,41,8,153,17.6,9.35,77,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","SAP18","ENSG00000150459","Nucleocytoplasmic transport; mRNA surveillance pathway","Potential therapeutics for SARS; HDACs deacetylate histones; NoRC negatively regulates rRNA expression","Hedgehog signaling pathway Netpath",4349.8,4333.4,4300.4,4930.1,5002.2,4738.1,0.8850201766822992,-0.17621774876779395,2.173597772182974E-3,2.662820819717667,0.04980196274885692,1.3027535408908753,319]
["O00425","Insulin-like growth factor 2 mRNA-binding protein 3 [OS=Homo sapiens]",2,2,2,2,579,63.7,8.87,2.02,"protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","IGF2BP3","ENSG00000136231","","Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA","",138,150.9,160.3,160.9,155.1,86.3,1.1165796669152372,0.15908618977497088,0.5628963954259254,0.24957153238730617,0.69391292868411,0.15869502084829698,5929]
["O00429","Dynamin-1-like protein [OS=Homo sapiens]",70,45,189,1,736,81.8,6.81,589.96,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","DNM1L","ENSG00000087470","Necroptosis; NOD-like receptor signaling pathway; TNF signaling pathway","Apoptotic execution phase","Synaptic vesicle pathway; CAMKK2 pathway",19044.7,19422.6,19801.8,18290.6,17781.6,15240.3,1.135573203410475,0.18342071070633836,0.0748046445846696,1.126071436161334,0.27133853462498764,0.5664885247544892,2015]
["O00429-2","Isoform 4 of Dynamin-1-like protein [OS=Homo sapiens]",71,45,192,1,725,80.5,6.71,609.4,"","","","DNM1L","","","","",385.7,381.9,377.2,402.7,419.6,447.6,0.9014883061658397,-0.14961931731290895,0.03517710511135382,1.4537399035339067,0.18417583184733888,0.734767359937076,1396]
["O00442","RNA 3'-terminal phosphate cyclase [OS=Homo sapiens]",44,14,51,14,366,39.3,7.85,155.6,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","RTCA","ENSG00000137996","","","",4303.7,4625.4,4665.6,4173.4,3915.1,3798.1,1.1436996281527096,0.1937082043238161,0.02333414283179553,1.6320081480789597,0.1511961435794269,0.8204592858423102,1128]
["O00443","phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [OS=Homo sapiens]",16,23,31,23,1686,190.6,8.02,87.31,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","PIK3C2A","ENSG00000011405","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Salmonella infection","Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane","Glioblastoma signaling pathways; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; Osteoblast differentiation and related diseases; Insulin signaling; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)",2455.7,2429.2,2440.5,2998.7,3003.3,3676.6,0.7568656623891884,-0.401890838802656,0.025327965979993906,1.5963996858167968,0.15755072625342592,0.8025795905405789,1175]
["O00459","Phosphatidylinositol 3-kinase regulatory subunit beta [OS=Homo sapiens]",6,3,5,3,728,81.5,6.43,10.37,"other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;cytosol;nucleus","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","PIK3R2","ENSG00000105647","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; Platinum drug resistance; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Phosphatidylinositol signaling system; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Osteoclast differentiation; Focal adhesion; Signaling pathways regulating pluripotency of stem cells; Platelet activation; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; TNF signaling pathway; Leukocyte transendothelial migration; Neurotrophin signaling pathway; Cholinergic synapse; Inflammatory mediator regulation of TRP channels; Regulation of actin cytoskeleton; Insulin signaling pathway; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Prolactin signaling pathway; Thyroid hormone signaling pathway; Regulation of lipolysis in adipocytes; Relaxin signaling pathway; GnRH secretion; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Aldosterone-regulated sodium reabsorption; Carbohydrate digestion and absorption; Alzheimer disease; Spinocerebellar ataxia; Prion disease; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection; Chagas disease; Amoebiasis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","Downstream TCR signaling; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOJ GTPase cycle; Nephrin family interactions; Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; RND2 GTPase cycle; RHOA GTPase cycle; G alpha (q) signalling events; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; Extra-nuclear estrogen signaling; RHOU GTPase cycle; PIP3 activates AKT signaling; Synthesis of PIPs at the plasma membrane; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Interleukin receptor SHC signaling; Regulation of signaling by CBL; RAF/MAP kinase cascade; PI3K Cascade; GPVI-mediated activation cascade; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; Costimulation by the CD28 family; CD28 dependent PI3K/Akt signaling; VEGFA-VEGFR2 Pathway; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; RND3 GTPase cycle; RND1 GTPase cycle","IL-5 signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase (AMPK) signaling; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL-6 signaling pathway; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Ebola virus pathway in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Modulators of TCR signaling and T cell activation; Orexin receptor pathway; Regulation of actin cytoskeleton; Alzheimer's disease; G13 signaling pathway; Interferon type I signaling pathways; Notch signaling pathway (Netpath); ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway",237.1,229.1,223.8,288,282.3,380.6,0.7256283520874961,-0.46269726826993407,0.05354584593930556,1.2712742158800308,0.22873558618958756,0.640666263537158,1711]
["O00461","Golgi integral membrane protein 4 [OS=Homo sapiens]",38,23,53,23,696,81.8,4.77,156.08,"","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","GOLIM4","ENSG00000173905","","Intra-Golgi traffic","",3733.4,3663.8,3648.4,4137.1,4307.5,3796.1,0.9023666947151715,-0.14821427433147275,0.059385390755478315,1.2263203815278945,0.2407364509327737,0.6184581463663235,1803]
["O00462","Beta-mannosidase [OS=Homo sapiens]",14,11,21,10,879,100.8,5.52,57.12,"protein metabolism;other metabolic processes","plasma membrane;other membranes;other cytoplasmic organelle","other molecular function","MANBA","ENSG00000109323","Other glycan degradation; Lysosome","Neutrophil degranulation; Lysosomal oligosaccharide catabolism","",1360.5,1386.2,1399.5,1318.6,1323.4,1890.2,0.9148316490887427,-0.12842181747014136,0.5355969386808819,0.271161913956145,0.6741308808022327,0.17125577810549622,5807]
["O00463","TNF receptor-associated factor 5 [OS=Homo sapiens]",2,1,3,1,557,64.4,7.43,5.82,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton","signal transduction activity or receptor binding;other molecular function","TRAF5","ENSG00000082512","NF-kappa B signaling pathway; Necroptosis; NOD-like receptor signaling pathway; IL-17 signaling pathway; TNF signaling pathway; Shigellosis; Human cytomegalovirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Viral carcinogenesis; Small cell lung cancer","","RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Small cell lung cancer; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling",30.9,23.4,40.5,38.9,36.8,20,0.9905956112852665,-0.013631865587766363,0.971024372162606,0.01276986940930125,0.9825857865341946,0.0076295223856199,7223]
["O00469-1","procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 [OS=Homo sapiens]",4,2,2,2,737,84.6,6.71,7.23,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","other molecular function","PLOD2","ENSG00000152952","Lysine degradation; Metabolic pathways","Collagen biosynthesis and modifying enzymes","Clear cell renal cell carcinoma pathways; Type I collagen synthesis in the context of osteogenesis imperfecta",188.2,173.2,156.2,213.1,233.8,283.6,0.7085557837097877,-0.49704665569835343,0.03612651486183124,1.442173932959535,0.1863434700953596,0.7296858213230225,1417]
["O00470","Homeobox protein Meis1 [OS=Homo sapiens]",2,1,1,1,390,43,6.33,2.92,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MEIS1","ENSG00000143995","Signaling pathways regulating pluripotency of stem cells; Transcriptional misregulation in cancer","Activation of anterior HOX genes in hindbrain development during early embryogenesis","Mesodermal commitment pathway",22.9,34,27.4,53,61.9,52.2,0.504488330341113,-0.9871071971191061,3.5177851532547173E-3,2.4537306883592858,0.06286428284874995,1.2015960344826546,409]
["O00471","Exocyst complex component 5 [OS=Homo sapiens]",21,14,26,14,708,81.8,6.71,63.68,"cell organization and biogenesis;transport;other biological processes","cytosol;other cell component","other molecular function","EXOC5","ENSG00000070367","Salmonella infection","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium","Ciliary landscape",2131,2111.6,2114.7,2119.4,2100,3453.2,0.8285718009540443,-0.27130137343101063,0.38307959412822823,0.416710981385597,0.57094795136281,0.24340348101198264,4904]
["O00479","High mobility group nucleosome-binding domain-containing protein 4 [OS=Homo sapiens]",27,3,5,3,90,9.5,10.48,8.92,"cell organization and biogenesis","nucleus;other cell component","nucleic acid binding activity;other molecular function","HMGN4","ENSG00000182952","","","",822.9,856.5,770.8,575.9,683.9,539,1.362130309094952,0.4458647263253063,0.012324520716163885,1.9092299608436394,0.11533920859723668,0.9380230328369668,781]
["O00481-1","Butyrophilin subfamily 3 member A1 [OS=Homo sapiens]",10,5,6,2,513,57.6,8.03,14.04,"cell cycle OR cell proliferation;signal transduction;other biological processes","plasma membrane;other membranes","signal transduction activity or receptor binding","BTN3A1","ENSG00000026950","","Butyrophilin (BTN) family interactions","",240.1,237.5,245.7,230.2,211.3,212.8,1.1054562127464467,0.14464188096177572,0.024403660054461776,1.6125450334050921,0.15469761607811025,0.8105163788158183,1153]
["O00483","Cytochrome c oxidase subunit NDUFA4 [OS=Homo sapiens]",56,5,23,5,81,9.4,9.38,59.42,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","NDUFA4","ENSG00000189043","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; Oxidative phosphorylation",4159.7,3775,4551.2,4209.6,5351,2755.8,1.0137621382871616,0.019719188663858626,0.9459875504998487,0.024114579015538394,0.9675654921079477,0.014319628997986557,7146]
["O00487","26S proteasome non-ATPase regulatory subunit 14 [OS=Homo sapiens]",47,12,47,12,310,34.6,6.52,121.33,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PSMD14","ENSG00000115233","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection","Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; Metalloprotease DUBs","Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease",5501.8,5925,6077.7,5230.7,5249.7,4488.4,1.169399016621239,0.22576728322944414,0.049864905785088336,1.302204997180296,0.22075263257614214,0.6560941085591167,1651]
["O00499","Myc box-dependent-interacting protein 1 [OS=Homo sapiens]",4,2,6,1,593,64.7,5.06,19.85,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","BIN1","ENSG00000136717","Endocytosis; Fc gamma R-mediated phagocytosis","Clathrin-mediated endocytosis","VEGFA-VEGFR2 signaling pathway; IL-18 signaling pathway",49.1,38.9,52.2,58.4,55.3,50.5,0.853836784409257,-0.2279677777671816,0.15896984088658847,0.7986852604524973,0.3904269378494876,0.40846022544236543,2976]
["O00505","Importin subunit alpha-4 [OS=Homo sapiens]",28,11,49,7,521,57.8,4.94,140.19,"cell organization and biogenesis;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","KPNA3","ENSG00000102753","Nucleocytoplasmic transport; Salmonella infection; Chemical carcinogenesis","ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways","",980.8,1033.8,1063,1016,1092.6,662.2,1.1107261440739136,0.15150315580134338,0.49007184771451956,0.30974024491321,0.6406609076990563,0.1933717752879099,5591]
["O00506","serine/threonine-protein kinase 25 [OS=Homo sapiens]",23,7,35,2,426,48.1,6.74,85.36,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","kinase activity;other molecular function","STK25","ENSG00000115694","","","",62.3,64.9,65.5,65.7,75,246.5,0.49767561983471076,-1.0067223809788735,0.33197503528269995,0.4788945742677086,0.5420923889368306,0.26592669024004806,4476]
["O00507-1","Probable ubiquitin carboxyl-terminal hydrolase FAF-Y [OS=Homo sapiens]",9,21,47,1,2555,290.9,5.86,131.75,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","USP9Y","ENSG00000114374","","","",130.2,161.4,134.4,115,132.6,181.1,{"$f":"AVERAGE(S130:U130)/AVERAGE(V130:X130)","v":0.9937018894331701},{"$f":"LOG(Y130,2)","v":-0.009114986703772043},{"$f":"TTEST(V130:X130,S130:U130,2,2)","v":0.9693977725072649},0.013497982538692574,{"$f":"AA130*7309/AE130","v":0.9818913967926274},0.00793654518860492,7216]
["O00512","B-cell CLL/lymphoma 9 protein [OS=Homo sapiens]",1,1,1,1,1426,149.2,8.91,0,"cell-cell signaling;developmental processes;signal transduction;other biological processes","ER/Golgi;nucleus","other molecular function","BCL9","ENSG00000116128","","Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex","Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; 1q21.1 copy number variation syndrome",18.9,13.1,17.6,15.7,17.8,45,0.6318471337579619,-0.662352533392114,0.37234036448633434,{"$f":"-LOG10(AA131)","v":0.42905988045243815},0.5664936977582468,{"$f":"-LOG10(AC131)","v":0.24680491729933368},4804]
["O00519","Fatty-acid amide hydrolase 1 [OS=Homo sapiens]",25,10,26,10,579,63,7.66,84.13,"other metabolic processes","other membranes;cytoskeleton;ER/Golgi","other molecular function","FAAH","ENSG00000117480","Retrograde endocannabinoid signaling","Arachidonic acid metabolism","Cannabinoid receptor signaling",2250.4,2207.3,2312.2,2007.5,2099.8,2778.6,0.9831539813241554,-0.024510706098259574,0.8822490860018891,0.05440878289096473,0.922511955591961,0.0350279967526732,6990]
["O00522","Krev interaction trapped protein 1 [OS=Homo sapiens]",9,6,11,6,736,84.3,8.41,34.25,"developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","KRIT1","ENSG00000001631","Rap1 signaling pathway","","",929.8,968.5,982.3,899.8,920,1279.5,0.9294356790242956,-0.10557306703526494,0.5891514264257487,0.22977306648802132,0.7125778215697165,0.1471676988525048,6043]
["O00534","von Willebrand factor A domain-containing protein 5A [OS=Homo sapiens]",5,4,4,4,786,86.4,6.58,7.8,"","nucleus","","VWA5A","ENSG00000110002","","","",464.9,469.2,486.5,451.6,417.8,420.5,1.1013256841615628,0.13924116594494645,0.02649693011430466,1.5768044397102723,0.16031958791842116,0.7950134121114124,1208]
["O00541-1","Pescadillo homolog [OS=Homo sapiens]",32,18,54,18,588,68,7.33,167.5,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PES1","ENSG00000100029","","Major pathway of rRNA processing in the nucleolus and cytosol","",6447.6,6316.5,6250.1,8828.2,8283.3,8207.2,0.7509943243531461,-0.41312609028830966,5.0072315762175485E-4,3.300402322731761,0.024077536572746094,1.6183879487925605,152]
["O00555-1","Voltage-dependent P/Q-type calcium channel subunit alpha-1A [OS=Homo sapiens]",1,1,2,1,2505,282.2,8.84,2.07,"","","","","","","","",700.8,935.7,950.9,536.3,571.9,221.5,1.9458524479205839,0.9604023161190222,0.03819888059448856,1.4179493637573963,0.19149219359747385,0.7178489258553793,1458]
["O00559","Receptor-binding cancer antigen expressed on SiSo cells [OS=Homo sapiens]",8,1,1,1,213,24.4,6.29,3.29,"other biological processes","other membranes;ER/Golgi;other cell component","enzyme regulator activity","EBAG9","ENSG00000147654","Estrogen signaling pathway","Estrogen-dependent gene expression","",35.8,44,36.3,42.6,51.4,74.3,0.6898395721925132,-0.5356672044643829,0.15090184537413642,0.8213054492177561,0.38190498193890693,0.4180446762313845,2888]
["O00560-1","Syntenin-1 [OS=Homo sapiens]",23,4,13,4,298,32.4,7.53,47.62,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","SDCBP","ENSG00000137575; ENSPPAG00000038846; ENSPTRG00000020277","","Neutrophil degranulation; Ephrin signaling; Neurofascin interactions; Regulation of necroptotic cell death","Ectoderm differentiation; Ectoderm differentiation; VEGFA-VEGFR2 signaling pathway",889.4,1021.1,1008.8,813.2,835.5,1467.3,0.9368741976893453,-0.0940727573066232,0.779055843762923,0.1084314104033859,0.851520736064484,0.06980477171931311,6687]
["O00566","U3 small nucleolar ribonucleoprotein protein Mpp10 [OS=Homo sapiens]",27,15,32,15,681,78.8,4.86,83.9,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","MPHOSPH10","ENSG00000124383","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",2130.9,2211.7,2113.7,3835.5,3701,2119.3,0.6686447523768098,-0.5806881771569807,0.12543975169663285,0.9015648143287129,0.3510103924772931,0.4546800250477763,2612]
["O00567","Nucleolar protein 56 [OS=Homo sapiens]",67,29,161,29,594,66,9.19,489.84,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NOP56","ENSG00000101361","Ribosome biogenesis in eukaryotes; Spinocerebellar ataxia","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; Association of TriC/CCT with target proteins during biosynthesis","",18458.8,17845.8,17971.3,17149.4,16242.9,16429.3,1.0894049970294006,0.12354038985387432,0.011249995546529381,1.9488476494742275,0.11007525762996419,0.9583102894056532,747]
["O00571","ATP-dependent RNA helicase DDX3X [OS=Homo sapiens]",58,34,224,33,662,73.2,7.18,686.69,"cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function","DDX3X","ENSG00000215301","RIG-I-like receptor signaling pathway; Hepatitis B; Viral carcinogenesis","Neutrophil degranulation","Novel intracellular components of RIG-I-like receptor (RLR) pathway; Hepatitis B infection",27551.8,27798.2,27648.6,33554.5,33132.1,22239.6,0.9333424794942322,-0.09952153599057169,0.6219850065206127,0.2062200842221161,0.7364471752242278,0.13285839930525276,6173]
["O00592","Podocalyxin [OS=Homo sapiens]",13,7,19,7,558,58.6,5.49,54.88,"cell adhesion;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","","PODXL","ENSG00000128567","Salmonella infection","","Primary focal segmental glomerulosclerosis (FSGS); Ectoderm differentiation; Hepatitis C and hepatocellular carcinoma; Nephrotic syndrome; Malignant pleural mesothelioma",2903.6,2934.1,3025,2436.9,2684,2327.5,1.1898797057086088,0.2508157275248102,0.013417697783321698,1.8723219942841058,0.11988991821307861,0.9212173360714558,818]
["O00625","Pirin [OS=Homo sapiens]",10,3,9,3,290,32.1,6.92,14.48,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PIR","ENSG00000087842","","Digestion","",1051.5,1105.3,1080.6,1135.8,1048.9,1355.1,0.9145714447143909,-0.12883221970931774,0.3367250215131246,0.4727246106647035,0.5446167696922832,0.26390899011193225,4519]
["O00629","Importin subunit alpha-3 [OS=Homo sapiens]",41,13,91,9,521,57.9,4.96,346.45,"transport","other membranes;cytosol;nucleus","other molecular function","KPNA4","ENSG00000186432","Nucleocytoplasmic transport; Salmonella infection; Chemical carcinogenesis","ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways","Leptin signaling pathway",9968,10435.1,10721.2,9700.6,10471,6426,1.1701920474027732,0.22674531878206852,0.29698213175188454,0.5272696796895215,0.5180530789915332,0.28562574077184383,4190]
["O00635","E3 ubiquitin-protein ligase TRIM38 [OS=Homo sapiens]",8,4,9,4,465,53.4,7.02,15.62,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","TRIM38","ENSG00000112343","","Interferon gamma signaling","",766.2,719.9,721.3,762.7,771.6,2036.2,0.6182327405125331,-0.6937780360902623,0.3435338394572665,0.4640304767537291,0.5477506179304452,0.2614171238290897,4584]
["O00743","Serine/threonine-protein phosphatase 6 catalytic subunit [OS=Homo sapiens]",33,9,31,9,305,35.1,5.69,93.67,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport","cytosol;mitochondrion;nucleus","other molecular function","PPP6C","ENSG00000119414","","Telomere Extension By Telomerase; COPII-mediated vesicle transport","",3813.1,3903.2,3773.7,3754.2,3731.2,3826,1.0157893806248564,0.022601296767742755,0.2808579885058259,0.5515132188782487,0.5059874384986643,0.29586026469860194,4057]
["O00746","Nucleoside diphosphate kinase, mitochondrial [OS=Homo sapiens]",16,2,4,2,187,20.6,10.29,10.56,"other metabolic processes;transport","other membranes;mitochondrion","kinase activity;other molecular function","NME4","ENSG00000103202","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors","Interconversion of nucleotide di- and triphosphates","Pyrimidine metabolism",401.9,436.5,471.6,361.1,418.5,419,1.0929417653929585,0.12821653274174494,0.2529090989832404,0.5970355456373004,0.48276641537438075,0.3162629501010151,3829]
["O00750","Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [OS=Homo sapiens]",2,3,3,3,1634,184.7,7.3,8.8,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","PIK3C2B","ENSG00000133056","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Salmonella infection","Synthesis of PIPs at the plasma membrane","Glioblastoma signaling pathways; S1P receptor signal transduction; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; EGF/EGFR signaling pathway; Osteoblast differentiation and related diseases; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)",184.4,159.6,162.6,200.9,207.5,222.7,0.8027254000950722,-0.3170215463404239,0.014919932447053294,1.8262331432131091,0.12448605736930654,0.9048792874972169,876]
["O00754","Lysosomal alpha-mannosidase [OS=Homo sapiens]",11,10,16,10,1011,113.7,7.28,49.54,"protein metabolism;other metabolic processes","non-structural extracellular;other membranes;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MAN2B1","ENSG00000104774","Other glycan degradation; Lysosome","Neutrophil degranulation; Lysosomal oligosaccharide catabolism","",1976.5,2018.8,2031.2,1786.6,1800,4479.4,0.7471485246714604,-0.42053303191602065,0.49004326158411377,0.30976557826146667,0.6407381393413752,0.19331942426391696,5590]
["O00762","Ubiquitin-conjugating enzyme E2 C [OS=Homo sapiens]",6,1,1,1,179,19.6,7.37,0,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","UBE2C","ENSG00000175063","Ubiquitin mediated proteolysis","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Gastric cancer network 1; Gastric cancer network 2",20.4,18.8,21.5,49.4,62.7,137.8,0.24289715886354543,-2.0415824798310216,0.08378241211016316,1.076847140381416,0.2879011048957134,0.5407566684001721,2127]
["O00763","Acetyl-CoA carboxylase 2 [OS=Homo sapiens]",5,9,16,5,2458,276.4,6.49,54.84,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus","other molecular function","ACACB","ENSG00000076555","Fatty acid biosynthesis; Pyruvate metabolism; Propanoate metabolism; Metabolic pathways; AMPK signaling pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Glucagon signaling pathway; Insulin resistance; Alcoholic liver disease","ChREBP activates metabolic gene expression; Biotin transport and metabolism; Carnitine metabolism; Activation of gene expression by SREBF (SREBP)","AMP-activated protein kinase (AMPK) signaling; Leptin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; IL-18 signaling pathway; 7q11.23 copy number variation syndrome",486.9,514.6,503.1,550.4,556.6,808,0.7856919060052219,-0.3479643966722684,0.18375602693262078,0.7357584077776177,0.4171033543014054,0.37975631758947564,3220]
["O00764-1","Pyridoxal kinase [OS=Homo sapiens]",57,17,137,17,312,35.1,6.13,367.38,"other metabolic processes","non-structural extracellular;nucleus;other cell component","kinase activity;other molecular function","HEL-S-1a; PDXK","ENSG00000160209","Vitamin B6 metabolism; Metabolic pathways; Biosynthesis of cofactors","Neutrophil degranulation; Vitamins B6 activation to pyridoxal phosphate","",11300.2,11938.7,11957,10624.9,10519.4,8501,1.1872337267627584,0.24760398152405236,0.06293802770850439,1.2010868707131395,0.24785239467751,0.6058068807120098,1856]
["O00767","acyl-CoA desaturase [OS=Homo sapiens]",13,5,23,5,359,41.5,9,75.05,"other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","SCD","ENSG00000099194","Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; AMPK signaling pathway; Alcoholic liver disease","Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis","Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Adipogenesis; Liver X receptor pathway; Nuclear receptors meta-pathway; Fatty acid biosynthesis; Angiopoietin-like protein 8 regulatory pathway; PPAR signaling pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways",3113.5,3124.3,3200.1,4986.8,6148,2671.5,0.6835937217067571,-0.5487889478793377,0.22741794800235982,0.6431752634354637,0.4581581537897596,0.33898457993954845,3628]
["O14492","SH2B adapter protein 2 [OS=Homo sapiens]",13,4,8,4,632,67.7,6.27,21.53,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;other molecular function","SH2B2","ENSG00000160999","Neurotrophin signaling pathway; Insulin signaling pathway","Regulation of KIT signaling; Factors involved in megakaryocyte development and platelet production","Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; Insulin signaling",94.6,101.6,90.8,120.6,118,143.7,0.7507193303688204,-0.4136544632715983,0.022223313922978508,1.6531911789167477,0.14860951643462939,0.8279533789824776,1093]
["O14494","Phospholipid phosphatase 1 [OS=Homo sapiens]",4,1,2,1,284,32.1,7.97,6.94,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","PLPP1","ENSG00000067113","Glycerolipid metabolism; Glycerophospholipid metabolism; Ether lipid metabolism; Sphingolipid metabolism; Metabolic pathways; Phospholipase D signaling pathway; Fc gamma R-mediated phagocytosis; Fat digestion and absorption; Choline metabolism in cancer","Sphingolipid de novo biosynthesis","Androgen receptor signaling pathway; Androgen receptor signaling pathway; Sphingolipid pathway; Triacylglyceride synthesis; Androgen receptor signaling pathway",384.5,345.6,350.9,358.4,327.4,393,1.0020393029291805,2.9390963864090237E-3,0.9755867651867205,0.01073409995872061,0.9854289202252267,0.006374696262523785,7236]
["O14497","AT-rich interactive domain-containing protein 1A [OS=Homo sapiens]",21,40,81,38,2285,241.9,6.7,259.41,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ARID1A","ENSG00000117713","Thermogenesis; Hepatocellular carcinoma","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines","Pathways affected in adenoid cystic carcinoma; Tumor suppressor activity of SMARCB1; Thermogenesis",7405.8,7350.9,7179.2,8249.5,8664.5,9550.9,0.8288676700081996,-0.2707863032529503,0.01795333738576633,1.745854807615072,0.13598025176431722,0.8665241590748914,965]
["O14523","Phospholipid transfer protein C2CD2L [OS=Homo sapiens]",21,11,23,11,706,76.1,7.69,62.31,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","transporter activity;other molecular function","C2CD2L","ENSG00000172375","","","",1208.5,1261.1,1232.9,958.5,1110.6,1685.9,0.9860186418109188,-0.020313172225424007,0.9409634403903917,0.026427250053252496,0.9653989031181041,0.015293198960485439,7124]
["O14524-1","Nuclear envelope integral membrane protein 1 [OS=Homo sapiens]",8,4,9,4,444,50.6,6.93,22.32,"cell organization and biogenesis","other membranes;nucleus","","NEMP1","ENSG00000166881","","","",1331.3,1385,1366.2,1438.4,1364.9,1897.1,0.8685431027146625,-0.2033306483354831,0.28558832277431534,0.5442595541029954,0.5099841317267215,0.2924433368642919,4093]
["O14526-1","F-BAR domain only protein 1 [OS=Homo sapiens]",4,4,4,4,889,96.8,6.96,10.43,"cell organization and biogenesis;transport","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","FCHO1","ENSG00000130475","","Cargo recognition for clathrin-mediated endocytosis","",149.2,152.7,139.8,185.4,176.8,409.7,0.5722243813965538,-0.8053471254148034,0.2228020842591364,0.6520807507603917,0.45525871787811795,0.34174172902538835,3577]
["O14530","Thioredoxin domain-containing protein 9 [OS=Homo sapiens]",33,6,14,6,226,26.5,5.88,40.52,"","cytosol;cytoskeleton;nucleus;other cell component","","TXNDC9","ENSG00000115514","","","",1165,1053.5,1077.6,1868.3,1816.3,1616,0.621835263932385,-0.6853956614541276,1.3555055178884159E-3,2.867898710187064,0.04027394239937574,1.39497585540647,246]
["O14531","dihydropyrimidinase-related protein 4 [OS=Homo sapiens]",11,2,16,2,572,61.8,7.09,35.54,"cell organization and biogenesis;developmental processes;other biological processes","cytosol","cytoskeletal activity;other molecular function","DPYSL4","ENSG00000151640","","CRMPs in Sema3A signaling","",895.8,879.4,840.9,791.6,747,1400.1,0.8902235682444619,-0.16776039892832695,0.6375816713258211,0.19546417617353404,0.7477670789025075,0.12623365895406913,6232]
["O14545","TRAF-type zinc finger domain-containing protein 1 [OS=Homo sapiens]",2,1,1,1,582,64.8,5.29,1.98,"other biological processes","","other molecular function","TRAFD1","ENSG00000135148","","","Regulation of toll-like receptor signaling pathway",109.8,104.5,103.1,121.2,127,28.6,1.1466763005780347,0.19745818519845734,0.6935909593024752,0.15889657636033022,0.7911136581681946,0.10176111755253851,6408]
["O14548","Cytochrome c oxidase subunit 7A-related protein, mitochondrial [OS=Homo sapiens]",11,1,1,1,114,12.6,9.42,3.72,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion;nucleus","transporter activity","COX7A2L","ENSG00000115944","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease",81,79.4,86.5,131,132,109,0.6637096774193548,-0.5913757848526119,0.005921168605396089,2.22759257219775,0.07970132842880297,1.0985344399026242,543]
["O14561","Acyl carrier protein, mitochondrial [OS=Homo sapiens]",13,2,3,2,156,17.4,4.93,8.5,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;nucleus","other molecular function","NDUFAB1","ENSG00000004779","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Glyoxylate metabolism and glycine degradation; Mitochondrial Fatty Acid Beta-Oxidation; Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",215.3,223.5,212.4,237.4,356.7,597,0.5467215179246077,-0.8711219364850389,0.16416257015625482,0.7847258571290641,0.3957335835330035,0.4025970922051071,3032]
["O14562","Ubiquitin domain-containing protein UBFD1 [OS=Homo sapiens]",19,4,13,4,309,33.4,5.77,35.8,"","","","UBFD1","ENSG00000103353","","","",1313.8,1299.1,1479.2,1890.3,1816.8,1556.1,0.7774927800577595,-0.3630988167157994,0.028687217016220706,1.542311581176179,0.1672048398497266,0.7767511557869037,1254]
["O14576-1","cytoplasmic dynein 1 intermediate chain 1 [OS=Homo sapiens]",6,3,4,3,645,72.9,5.12,8.9,"transport;other biological processes","cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","DNCI1; DYNC1I1","ENSG00000158560; ENSGGOG00000000228; ENSPTRG00000019422","Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection","Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Intraflagellar transport proteins binding to dynein",216.4,198.3,209.2,227.8,215.2,327.7,0.8095238095238095,-0.3048545815284209,0.24535524952456103,0.6102046455894851,0.4754245807993151,0.32291836777080285,3772]
["O14578-4","Isoform 4 of Citron Rho-interacting kinase [OS=Homo sapiens]",5,9,11,9,2069,236.5,6.67,18.9,"","","","CIT","","","","",634.9,720.9,696,653.9,668.8,616.2,1.0582288926711023,0.08165171309062032,0.27746517171942536,0.5567915230974926,0.5035989421647082,0.2979151908209512,4027]
["O14579-1","coatomer subunit epsilon [OS=Homo sapiens]",36,11,48,11,308,34.5,5.12,138.59,"transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","COPE","ENSG00000105669; ENSPTRG00000010723","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport","",5615.1,5915.2,6153.4,5904.8,5629.1,4351.1,1.1132326093799179,0.15475507456337287,0.29941257853443815,0.5237299585910041,0.5203058812430358,0.28374126505733344,4206]
["O14593","DNA-binding protein RFXANK [OS=Homo sapiens]",4,1,1,1,260,28.1,4.55,0,"signal transduction;other biological processes","non-structural extracellular;cytosol;nucleus","nucleic acid binding activity;other molecular function","RFXANK","ENSG00000064490","Antigen processing and presentation; Tuberculosis; Primary immunodeficiency","","",47,57.5,70.8,97.1,92.3,180.7,0.4736557687111592,-1.0780891395406822,0.09264937284982522,1.0331575161052786,0.30163664416898556,0.5205158995606476,2245]
["O14617-5","Isoform 5 of AP-3 complex subunit delta-1 [OS=Homo sapiens]",36,40,125,40,1215,136.6,7.64,411.02,"","","","AP3D1","","","","",12950.6,12721.1,12400.6,12059.2,12303.9,11535.3,1.0605570164687008,0.08482218349504973,0.05915583907243555,1.22800238118347,0.24007219754604744,0.6196581321190302,1801]
["O14618","copper chaperone for superoxide dismutase [OS=Homo sapiens]",16,5,19,5,274,29,5.58,36.89,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","CCS","ENSG00000173992","Amyotrophic lateral sclerosis; Pathways of neurodegeneration","Detoxification of Reactive Oxygen Species","Amyotrophic lateral sclerosis (ALS); Copper homeostasis",1897.1,1899.3,1916.9,1892.3,1917,3252.6,0.8090315637434684,-0.305732105498031,0.3737897692258721,0.42737258960661006,0.5676354505031995,0.24593048939999557,4813]
["O14628-1","Zinc finger protein 195 [OS=Homo sapiens]",7,3,4,1,629,72.3,8.09,5.49,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF195","ENSG00000005801","Herpes simplex virus 1 infection","Generic Transcription Pathway","",26,25.9,31.8,25.6,36.6,9.4,1.1689944134078212,0.22526803528608724,0.6461117797897562,0.1896923409114597,0.754141009020014,0.12254744230838321,6262]
["O14639-1","Actin-binding LIM protein 1 [OS=Homo sapiens]",7,5,6,5,778,87.6,8.59,12.99,"cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ABLIM1","ENSG00000099204","Axon guidance","DCC mediated attractive signaling","Male infertility",718.3,696.4,675.1,767.6,728.4,1006,0.835251798561151,-0.25971691074530356,0.19197758878479892,0.7167494673130405,0.42623456756625006,0.37035133196929976,3292]
["O14641","Segment polarity protein dishevelled homolog DVL-2 [OS=Homo sapiens]",6,4,6,2,736,78.9,6.02,11.66,"cell-cell signaling;cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","DVL2","ENSG00000004975","mTOR signaling pathway; Wnt signaling pathway; Notch signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer","RHO GTPases Activate Formins; Asymmetric localization of PCP proteins; Degradation of DVL; Cargo recognition for clathrin-mediated endocytosis; WNT mediated activation of DVL; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Negative regulation of TCF-dependent signaling by DVL-interacting proteins; WNT5:FZD7-mediated leishmania damping; Signaling by Hippo; WNT5A-dependent internalization of FZD4","Alzheimer's disease and miRNA effects; Neural crest differentiation; Notch signaling; Wnt signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Type 2 papillary renal cell carcinoma; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Malignant pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)",204.7,176.5,198,252.2,264.8,468.8,0.5875431121931428,-0.7672333785880248,0.1277400616433092,0.893672878601217,0.35352219255999506,0.4515833179241681,2641]
["O14646","Chromodomain-helicase-DNA-binding protein 1 [OS=Homo sapiens]",13,18,26,15,1710,196.6,7.14,58.47,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CHD1","ENSG00000153922","","Estrogen-dependent gene expression","",2119.3,2026.3,2052.6,2481.4,2504.8,2489.5,0.8291129927632196,-0.27035936712201153,1.1713027696074184E-4,3.9313308298005882,0.012971290822819124,1.8870168034584838,66]
["O14647","Chromodomain-helicase-DNA-binding protein 2 [OS=Homo sapiens]",11,17,26,14,1828,211.2,8.1,66.08,"cell organization and biogenesis;stress response;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","CHD2","ENSG00000173575","","","Prion disease pathway; Male infertility",1417.9,1422.1,1391.9,1564.8,1646.3,1463,0.9053935516997923,-0.14338306327826106,0.05207221943448271,1.2833939113274389,0.22587290910779473,0.6461358546508232,1685]
["O14653-1","Golgi SNAP receptor complex member 2 [OS=Homo sapiens]",21,4,7,4,212,24.8,8.06,14.57,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","other molecular function","GOSR2","ENSG00000108433","SNARE interactions in vesicular transport","COPI-mediated anterograde transport; Intra-Golgi traffic; COPII-mediated vesicle transport; XBP1(S) activates chaperone genes; Cargo concentration in the ER","",611.4,612.8,601.6,641.8,730.6,596,0.9275553749237958,-0.10849468189438764,0.29694869785625144,0.5273185747987614,0.5182421281354684,0.28546728592159315,4188]
["O14656","Torsin-1A [OS=Homo sapiens]",20,6,14,6,332,37.8,6.99,37.88,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","TOR1A","ENSG00000136827","","Cargo recognition for clathrin-mediated endocytosis","",1292.8,1299.7,1294.5,1348,1279,1088.1,1.0462706252859952,0.06525606311447511,0.5020597876604612,0.2992445619288486,0.6491340859738742,0.1876655855049943,5653]
["O14662-2","Isoform A of Syntaxin-16 [OS=Homo sapiens]",24,7,16,7,304,34.8,6.2,46.86,"","","","STX16","","","","",959.9,1017.1,991.8,834.2,976.3,1727.1,0.83921302578019,-0.25289102411869996,0.5319730365800065,0.27411037966224083,0.6717676095997352,0.17278094022526772,5788]
["O14672","Disintegrin and metalloproteinase domain-containing protein 10 [OS=Homo sapiens]",38,25,56,25,748,84.1,7.77,170.99,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ADAM10","ENSG00000137845","Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection","Amyloid fiber formation; Collagen degradation; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; NOTCH3 Activation and Transmission of Signal to the Nucleus; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant; Signaling by EGFR; EPH-ephrin mediated repulsion of cells; NOTCH4 Activation and Transmission of Signal to the Nucleus","Alzheimer's disease and miRNA effects; Copper homeostasis; Canonical and non-canonical Notch signaling; VEGFA-VEGFR2 signaling pathway; 3q29 copy number variation syndrome; Interactions of natural killer cells in pancreatic cancer; Alzheimer's disease; Hypertrophy model",3981.3,4113.7,4058.4,4325.1,4485.8,5928.8,0.8245350990861414,-0.2783471867919597,0.16708303485757328,0.7770676449108234,0.3988275316048345,0.39921486938909256,3062]
["O14681","Etoposide-induced protein 2.4 homolog [OS=Homo sapiens]",2,1,3,1,340,38.9,9.72,5.03,"other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus","other molecular function","EI24","ENSG00000149547","p53 signaling pathway","","miRNA regulation of p53 pathway in prostate cancer; Genotoxicity pathway",442,429.6,444.3,380.7,391.1,705.4,0.8908069320335773,-0.16681531003113292,0.6406338878683664,0.1933900920147286,0.7501430769673005,0.12485589446006953,6242]
["O14683","Tumor protein p53-inducible protein 11 [OS=Homo sapiens]",8,1,2,1,189,21,9.55,8.88,"other biological processes","other membranes","","TP53I11","ENSG00000175274","","","",146.9,150.1,137.6,133.4,139.1,273.4,0.7961165048543689,-0.32894852256513474,0.4642546585910759,0.3332437296124217,0.6213582310276824,0.20665794426399214,5461]
["O14686-1","Histone-lysine N-methyltransferase 2D [OS=Homo sapiens]",4,13,15,12,5537,593,5.58,42.08,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","KMT2D","ENSG00000167548","Lysine degradation; Metabolic pathways; Cushing syndrome","Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","Histone modifications; 16p11.2 proximal deletion syndrome",553.7,580.2,559.3,707.1,728.6,1326.8,0.6129230769230769,-0.7062220707350984,0.15433501955639858,0.8115355186906601,0.3867105443735746,0.41261398592841986,2917]
["O14717-1","tRNA (cytosine(38)-C(5))-methyltransferase [OS=Homo sapiens]",2,1,2,1,391,44.6,6.09,5.15,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DNMT2; TRDMT1","ENSG00000107614","","tRNA modification in the nucleus and cytosol","",358.3,403.3,392,326.9,433.1,151.6,1.2654673102237823,0.33967023997552537,0.38706785033623425,0.4122128994674266,0.5737333032057466,0.24128994011459137,4931]
["O14730","serine/threonine-protein kinase RIO3 [OS=Homo sapiens]",12,6,7,6,519,59.1,5.76,17.24,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;other cell component","kinase activity;other molecular function","RIOK3","ENSG00000101782","","Major pathway of rRNA processing in the nucleolus and cytosol","",700.6,721.8,695.6,776.7,803.3,958,0.83451536643026,-0.2609894798487695,0.07027883954963467,1.1531754182261311,0.2627457996257186,0.5804642180740437,1955]
["O14732-1","inositol monophosphatase 2 [OS=Homo sapiens]",7,2,2,2,288,31.3,6.61,5.48,"other metabolic processes;signal transduction","cytosol;other cell component","other molecular function","IMPA2","ENSG00000141401","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of IP2, IP, and Ins in the cytosol","",159.2,158.4,153.2,166.1,172.4,249.5,0.8006802721088435,-0.32070183468528257,0.21975159919219978,0.6580679557635386,0.4544890884255201,0.34247653905031095,3534]
["O14733","dual specificity mitogen-activated protein kinase kinase 7 [OS=Homo sapiens]",18,6,10,6,419,47.5,9.16,26.35,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","MAP2K7","ENSG00000076984","MAPK signaling pathway; ErbB signaling pathway; Protein processing in endoplasmic reticulum; Osteoclast differentiation; Tight junction; Toll-like receptor signaling pathway; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; TNF signaling pathway; Neurotrophin signaling pathway; GnRH signaling pathway; Relaxin signaling pathway; Alcoholic liver disease; Alzheimer disease; Huntington disease; Pathways of neurodegeneration; Salmonella infection; Yersinia infection; Hepatitis B; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Chemical carcinogenesis; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; Uptake and function of anthrax toxins","Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; MAPK signaling pathway; ERK pathway in Huntington's disease; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; MAPK cascade; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; IL-18 signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Malignant pleural mesothelioma; Alzheimer's disease; ErbB signaling pathway; Toll-like receptor signaling pathway",1122.8,1186,1173.3,1208.7,1302.9,933.7,1.01068121789104,0.015328024055776246,0.918370746664618,0.03698195853111256,0.9494160943948646,0.022543410444039024,7070]
["O14734","Acyl-coenzyme A thioesterase 8 [OS=Homo sapiens]",20,5,8,5,319,35.9,7.56,23.55,"cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle","other molecular function","ACOT8","ENSG00000101473","Primary bile acid biosynthesis; Metabolic pathways; Peroxisome","Peroxisomal protein import; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of pristanoyl-CoA; Beta-oxidation of very long chain fatty acids","",608.7,672.9,688.3,571,491.8,526,1.239866565961732,0.3101848665931456,0.019175552827049976,1.7172521065823008,0.13959573268217956,0.8551278575073283,1004]
["O14735","CDP-diacylglycerol--inositol 3-phosphatidyltransferase [OS=Homo sapiens]",25,5,18,5,213,23.5,8.03,34.86,"other metabolic processes","plasma membrane;other membranes;ER/Golgi","other molecular function","CDIPT","ENSG00000103502","Inositol phosphate metabolism; Glycerophospholipid metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of PI","Glycerolipids and glycerophospholipids; 16p11.2 proximal deletion syndrome",1599.4,1621.3,1681.3,1314.8,1364.5,1431.9,1.1923525977816694,0.25381092694904656,3.2445057035998615E-3,2.4888514580471384,0.06049513313166171,1.2182795631836225,392]
["O14744","Protein arginine N-methyltransferase 5 [OS=Homo sapiens]",37,21,49,21,637,72.6,6.29,162.74,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","PRMT5","ENSG00000100462","","snRNP Assembly; RMTs methylate histone arginines; Regulation of TP53 Activity through Methylation","Transcription co-factors SKI and SKIL protein partners; Nitric oxide metabolism in cystic fibrosis",6653.7,6696.6,6590.8,6239.4,6233.2,6015.1,1.07861443013463,0.10917924004066928,0.003735342393955015,2.4276695831417734,0.0653148745392756,1.1849879030328356,418]
["O14745","Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [OS=Homo sapiens]",69,21,108,21,358,38.8,5.77,328.28,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;transporter activity;cytoskeletal activity;other molecular function","SLC9A3R1","ENSG00000109062","Tight junction; Parathyroid hormone synthesis, secretion and action; Pathogenic Escherichia coli infection; Human papillomavirus infection","","",14216.6,13025.7,12875.9,14842,14667.6,15476.2,0.8917969670429335,-0.16521280176117806,0.029648521860333774,1.5279969536960947,0.1710347642282396,0.766915606695563,1267]
["O14757","Serine/threonine-protein kinase Chk1 [OS=Homo sapiens]",4,2,2,2,476,54.4,8.25,5.21,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","CHEK1","ENSG00000149554","Cell cycle; p53 signaling pathway; Cellular senescence; Human T-cell leukemia virus 1 infection; Human immunodeficiency virus 1 infection; Viral carcinogenesis","Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Transcriptional Regulation by E2F6; Signaling by SCF-KIT; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex","miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; ATR signaling; ATM signaling in development and disease ; DNA repair pathways, full network; DNA damage response",168.4,178.2,190.8,468.5,406.6,199.1,0.5002792776019364,-0.9991944001423678,0.09374819529954519,1.0280370839095019,0.30359129793725115,0.5177106811032909,2257]
["O14772","fucose-1-phosphate guanylyltransferase [OS=Homo sapiens]",3,1,1,1,594,66.6,6.48,3.55,"","","other molecular function","FPGT","ENSG00000254685","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars","","",34.3,32.3,40.4,39.5,25.4,45,0.9736123748862602,-0.0385805896607219,0.8859250779644794,0.05260300452652462,0.9255612342541994,0.03359484344919061,6996]
["O14773","Tripeptidyl-peptidase 1 [OS=Homo sapiens]",32,10,45,10,563,61.2,6.48,142.15,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","TPP1","ENSG00000166340","Lysosome","XBP1(S) activates chaperone genes","VEGFA-VEGFR2 signaling pathway",5497.8,5662.6,5851.9,5407.2,5617.3,6027.4,{"$f":"AVERAGE(S194:U194)/AVERAGE(V194:X194)","v":0.9976776781473032},{"$f":"LOG(Y194,2)","v":-3.3542986099956576E-3},{"$f":"TTEST(V194:X194,S194:U194,2,2)","v":0.952643667399617},0.02106951512336041,{"$f":"AA194*7309/AE194","v":0.9721966720223124},0.012245869915271535,7162]
["O14776-1","Transcription elongation regulator 1 [OS=Homo sapiens]",25,33,92,33,1098,123.8,8.65,229.28,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","TCERG1","ENSG00000113649; ENSGGOG00000003329; ENSPTRG00000017375","Spliceosome","","",12663,12492.8,12370.2,13546.6,13575.3,13963.2,0.9133724878362227,-0.13072476067802113,1.7206818562180823E-3,{"$f":"-LOG10(AA195)","v":2.7642994207017124},0.04491594173963558,{"$f":"-LOG10(AC195)","v":1.3475994901599586},280]
["O14777","Kinetochore protein NDC80 homolog [OS=Homo sapiens]",29,18,37,18,642,73.9,5.6,94.67,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","NDC80","ENSG00000080986","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",4286.1,4417.9,4488.4,5123.2,5579.2,3890,0.9040596474877333,-0.14551013386646616,0.41027862722453395,0.3869211062848807,0.5877550933720342,0.23080359867467892,5102]
["O14782","Kinesin-like protein KIF3C [OS=Homo sapiens]",3,3,5,1,793,89.4,8.22,10.83,"transport;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF3C","ENSG00000084731","","Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins","",299.3,264.3,267.4,329.1,273.9,497.8,0.754905523255814,-0.40563199304439107,0.2581127809260867,0.5881904900386781,0.48572253238639745,0.3136117493906724,3884]
["O14787-2","Isoform 2 of Transportin-2 [OS=Homo sapiens]",30,19,68,11,887,100.3,4.98,205.82,"","","","TNPO2","","","","",1709,1757.2,1687.5,1506.4,1518.2,1350.3,1.1780154974970853,0.23635851880769718,0.010958653140983552,1.9602428189704921,0.10897523239108678,0.9626721961707141,735]
["O14795","Protein unc-13 homolog B [OS=Homo sapiens]",14,16,28,16,1591,180.6,5.99,85.29,"cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","UNC13B","ENSG00000198722","Synaptic vesicle cycle","Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle","Synaptic vesicle pathway; 16p11.2 proximal deletion syndrome; Monoamine transport",1751.4,1809.6,1762.2,1847.4,1900.7,2540.4,0.8464975749383796,-0.24042215981946957,0.22314461835793994,0.6514135827003673,0.4557038322375477,0.34131731920639863,3579]
["O14802","DNA-directed RNA polymerase III subunit RPC1 [OS=Homo sapiens]",22,26,44,25,1390,155.5,8.48,120,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR3A","ENSG00000148606","RNA polymerase; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","Pyrimidine metabolism; Cytosolic DNA-sensing pathway",4603.6,4597.7,4637.9,4610.6,4636.6,4556,1.0026080908774777,0.003757781584495741,0.6781074998824492,0.16870145229081163,0.7788007097172881,0.10857366138138257,6364]
["O14818-1","Proteasome subunit alpha type-7 [OS=Homo sapiens]",63,16,110,16,248,27.9,8.46,348.28,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","HEL-S-276; PSMA7","ENSG00000101182","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease",11552.9,12154.8,12778.2,12164.8,11610.6,8384.4,1.134518871386016,0.18208060674368823,0.3063087810272075,0.5138405529910142,0.5252958424513983,0.27959603648522446,4262]
["O14828","Secretory carrier-associated membrane protein 3 [OS=Homo sapiens]",56,13,79,13,347,38.3,7.64,296.69,"transport","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SCAMP3","ENSG00000116521; ENSG00000263290","","","",5589.4,5203.3,5292.6,5118.4,5874.1,5729.6,0.9619186585416906,-0.05601319245137701,0.4590419223642067,0.3381476503667701,0.6181166931761214,0.20892952747049656,5428]
["O14832","Phytanoyl-CoA dioxygenase, peroxisomal [OS=Homo sapiens]",5,2,2,2,338,38.5,8.47,4.08,"other metabolic processes","cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","PHYH","ENSG00000107537","Peroxisome","TYSND1 cleaves peroxisomal proteins; Alpha-oxidation of phytanate","",195.2,188.6,198.7,169.8,191.3,148.7,1.142604943114947,0.19232667640680307,0.12788852903923717,0.8931684078151294,0.3537991138333779,0.4512432592096648,2642]
["O14836","Tumor necrosis factor receptor superfamily member 13B [OS=Homo sapiens]",7,1,1,1,293,31.8,7.94,4.71,"developmental processes;signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","TNFRSF13B","ENSG00000240505","Cytokine-cytokine receptor interaction; Intestinal immune network for IgA production; Primary immunodeficiency","TNFs bind their physiological receptors","",53.3,35.5,35,60.8,62.7,176.9,0.41211717709720375,-1.2788734983000072,0.20434931960748298,0.6896268039578078,0.4403269979395911,0.35622468565851106,3392]
["O14867","Transcription regulator protein BACH1 [OS=Homo sapiens]",9,6,6,6,736,81.9,5.05,18.29,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","BACH1","ENSG00000156273","","Heme signaling; Regulation of HMOX1 expression and activity; Regulation of BACH1 activity","Integrated cancer pathway; Ferroptosis",261.8,236.2,242.6,314.9,280.4,374.4,0.7637413633082398,-0.38884393443432413,0.05531312203567305,1.2571718279781428,0.2326142744296515,0.6333636382068175,1738]
["O14874","[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial [OS=Homo sapiens]",24,7,11,7,412,46.3,8.82,34.8,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","kinase activity;other molecular function","BCKDK","ENSG00000103507","","Branched-chain amino acid catabolism","Thiamine metabolic pathways",1343.5,1149.2,1160.4,1556.8,1344.9,1617.2,0.8084047002589126,-0.30685038497017075,0.04985950060510924,1.3022520757225684,0.22086247874105663,0.6558780580525017,1650]
["O14880","Microsomal glutathione S-transferase 3 [OS=Homo sapiens]",38,4,23,4,152,16.5,9.38,79.97,"other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","MGST3","ENSG00000143198","Glutathione metabolism; Metabolism of xenobiotics by cytochrome P450; Drug metabolism; Drug metabolism; Metabolic pathways; Platinum drug resistance; Pathways in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Chemical carcinogenesis; Hepatocellular carcinoma; Fluid shear stress and atherosclerosis","Aflatoxin activation and detoxification; Glutathione conjugation","Nuclear receptors meta-pathway; NRF2 pathway; Metapathway biotransformation Phase I and II",3552.6,3497.4,3578.5,3059.4,3020.6,1386.6,1.4234725310047411,0.5094146534134394,0.12872057854075597,0.8903520169474574,0.35382426045670756,0.4512123923950514,2659]
["O14893","Gem-associated protein 2 [OS=Homo sapiens]",14,3,6,3,280,31.6,5.58,17.9,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","","GEMIN2","ENSG00000092208","","snRNP Assembly","",416.1,368.8,405,461.3,546.8,1025.1,0.5852350973834352,-0.7729118023373491,0.1854858782528859,0.7316891492850797,0.41907767670798857,0.3777054724058259,3235]
["O14920-1","Inhibitor of nuclear factor kappa-B kinase subunit beta [OS=Homo sapiens]",26,12,24,12,756,86.5,5.78,76.67,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","IKBKB","ENSG00000104365","Antifolate resistance; MAPK signaling pathway; Ras signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; FoxO signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; TNF signaling pathway; Neurotrophin signaling pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; Alcoholic liver disease; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Chagas disease; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Pancreatic cancer; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; CLEC7A (Dectin-1) signaling; IKK complex recruitment mediated by RIP1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation","Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNAs involvement in the immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Nonalcoholic fatty liver disease; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; Insulin signaling; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; T-cell receptor (TCR) signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway",1791.5,1794.9,1844.8,1795.6,1692.1,1936.7,1.001253594867635,1.8074224476178253E-3,0.9767013493236879,0.010238212298189997,0.9860096909125462,0.006118816611363961,7240]
["O14929","histone acetyltransferase type B catalytic subunit [OS=Homo sapiens]",44,14,93,14,419,49.5,5.69,261.91,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","mitochondrion;nucleus;other cell component","other molecular function","HAT1","ENSG00000128708","Neutrophil extracellular trap formation; Alcoholism","HATs acetylate histones","Ethanol effects on histone modifications",10397.7,10940.6,11199.7,10441.6,9834.6,9981.5,1.0753626349656453,0.10482324906535037,0.0637060591884084,1.1958192592353751,0.2491319350498004,0.6035705987302342,1869]
["O14933","Ubiquitin/ISG15-conjugating enzyme E2 L6 [OS=Homo sapiens]",15,2,3,2,153,17.8,7.88,9.18,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","UBE2L6","ENSG00000156587","Ubiquitin mediated proteolysis; Parkinson disease; Pathways of neurodegeneration","Antigen processing: Ubiquitination & Proteasome degradation; Amyloid fiber formation; ISG15 antiviral mechanism; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling","Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway; 7q11.23 copy number variation syndrome",340.7,329.4,397.5,619.4,783.5,462.4,0.5723476116442394,-0.8050364701323198,0.04896033837585402,1.3101555893457797,0.2187353992598515,0.660080926797111,1636]
["O14936","peripheral plasma membrane protein CASK [OS=Homo sapiens]",6,5,8,5,926,105.1,6.43,25.47,"cell adhesion;protein metabolism;other metabolic processes;transport;other biological processes","extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","CASK","ENSG00000147044","","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Assembly and cell surface presentation of NMDA receptors; Nephrin family interactions; Neurexins and neuroligins; Dopamine Neurotransmitter Release Cycle; Syndecan interactions","Parkin-ubiquitin proteasomal system pathway; Splicing factor NOVA regulated synaptic proteins",747.6,787.2,833.8,609.2,608.6,881.8,1.1281196418365402,0.17392007973236534,0.3955900507563806,0.4027546396126204,0.57873652541601,0.2375191074307454,4996]
["O14949","Cytochrome b-c1 complex subunit 8 [OS=Homo sapiens]",30,4,17,4,82,9.9,10.08,40.67,"other metabolic processes;transport;developmental processes","other membranes;mitochondrion","","UQCRQ","ENSG00000164405","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly",3207.1,2750.6,3584.7,3560.8,4564.9,2446,0.902636283662987,-0.14778332253178836,0.6294803788129997,0.2010178024998021,0.741836841139022,0.12969160251713674,6202]
["O14950","Myosin regulatory light chain 12B [OS=Homo sapiens]",66,11,109,11,172,19.8,4.84,318.93,"other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYL12B","ENSG00000118680","Axon guidance; Focal adhesion; Tight junction; Platelet activation; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Shigellosis; Salmonella infection","RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs","Thyroid stimulating hormone (TSH) signaling pathway; Focal adhesion",9010.6,7470.8,8346.4,8901,9224.1,9556.3,0.8969127284024653,-0.15696048034065893,0.12102572979978204,0.917122289830947,0.3456729422065678,0.46133461383415947,2559]
["O14964","Hepatocyte growth factor-regulated tyrosine kinase substrate [OS=Homo sapiens]",26,19,36,19,777,86.1,6.16,92.11,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","HGS","ENSG00000185359","Endocytosis; Phagosome","Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; Endosomal Sorting Complex Required For Transport (ESCRT); Ub-specific processing proteases; RHOU GTPase cycle; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Inhibition of membrane repair; Prevention of phagosomal-lysosomal fusion; RHOBTB3 ATPase cycle","TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway",3978,4392.9,4590.6,4465.3,4814.4,6327.4,0.8304874063727405,-0.26796980376334745,0.21512860523080693,0.6673018384832062,0.45027920264374793,0.34651811163276547,3492]
["O14965","Aurora kinase A [OS=Homo sapiens]",15,5,6,5,403,45.8,9.39,16.59,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","AURKA","ENSG00000087586","Oocyte meiosis; Progesterone-mediated oocyte maturation","APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; SUMOylation of DNA replication proteins; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Interaction between PHLDA1 and AURKA","Integrated breast cancer pathway; Gastric cancer network 1; EGF/EGFR signaling pathway",475,545.7,507.8,536.9,485.6,846.2,0.8179483063091989,-0.2899184260332443,0.3779150138975895,0.42260585398573697,0.5688181294434682,0.24502657016896517,4856]
["O14967","calmegin [OS=Homo sapiens]",22,10,25,9,610,70,4.69,63.37,"cell organization and biogenesis;stress response;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","CLGN","ENSG00000153132","","","",1663.6,1568.7,1522.1,1482,1599.7,1672.4,1.000063103426516,9.1036128182047008E-5,0.9989186605345184,4.6987385530451433E-4,0.9997393522999856,1.1321261278164108E-4,7303]
["O14972","Down syndrome critical region protein 3 [OS=Homo sapiens]",16,3,8,3,297,33,7.68,19.29,"transport","other cytoplasmic organelle","","VPS26C","ENSG00000157538","","","",545.8,568.7,568.2,534.5,480.3,399,1.1901966331871552,0.2511999418433601,0.0890517807668676,1.0503573915349151,0.2955855883855746,0.5293167442866752,2202]
["O14974","Protein phosphatase 1 regulatory subunit 12A [OS=Homo sapiens]",51,50,148,3,1030,115.2,5.4,403.41,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP1R12A","ENSG00000058272","cGMP-PKG signaling pathway; cAMP signaling pathway; Vascular smooth muscle contraction; Focal adhesion; Platelet activation; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Proteoglycans in cancer","Regulation of PLK1 Activity at G2/M Transition; RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs","Focal adhesion; Hippo-Merlin signaling dysregulation; Regulation of actin cytoskeleton",20308.1,20373.9,20273.4,22099,22183.2,14814.9,1.0314448593924237,0.04466669741688655,0.812291513743757,0.09028808394835913,0.8756694209370383,0.05765981593144954,6780]
["O14974-4","Isoform 4 of Protein phosphatase 1 regulatory subunit 12A [OS=Homo sapiens]",53,48,152,1,971,109,5.41,415.41,"","","","PPP1R12A","","","","",624.6,560.4,536.8,615.7,604.8,512.4,0.9935945524842749,-9.270831076820309E-3,0.9339967334194965,0.029654642678223746,0.9605434254345153,0.017482996236678282,7107]
["O14975","very long-chain acyl-CoA synthetase [OS=Homo sapiens]",23,11,29,11,620,70.3,8.51,72.21,"other metabolic processes;transport","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","transporter activity;other molecular function","SLC27A2","ENSG00000140284","PPAR signaling pathway; Peroxisome; Insulin resistance","Peroxisomal protein import; Neutrophil degranulation; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Alpha-oxidation of phytanate; Synthesis of bile acids and bile salts via 24-hydroxycholesterol","PPAR signaling pathway",2352.2,2516.7,2605.1,2091.2,2281.9,3344.1,0.9684859793707563,-0.046196931591816814,0.8480690336263964,0.07156879432024515,0.9016053188036846,0.04498353493857245,6875]
["O14976","Cyclin-G-associated kinase [OS=Homo sapiens]",23,22,59,22,1311,143.1,5.73,183.19,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;ER/Golgi;other cell component","kinase activity;other molecular function","GAK","ENSG00000178950","","Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis","",5537.3,5092.5,5008.2,5640.1,5590.7,6262.5,0.8939422521765478,-0.1617464572029449,0.08492591648762995,1.0709597576946404,0.2896516675726026,0.5381239668524961,2143]
["O14979-1","Heterogeneous nuclear ribonucleoprotein D-like [OS=Homo sapiens]",30,15,127,13,420,46.4,9.57,302.04,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","HNRNPDL; HNRPDL","ENSG00000152795; ENSPPAG00000043177; ENSPTRG00000016217","","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","",11707.2,12044.6,11950.2,12641.1,14005.7,8899.1,1.004391505068095,0.006321731762712028,0.9744958750710813,0.011219994861043301,0.9845991637952077,6.740537402671277E-3,7234]
["O14980","Exportin-1 [OS=Homo sapiens]",47,39,166,39,1071,123.3,6.06,503.63,"transport;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","XPO1","ENSG00000082898","Ribosome biogenesis in eukaryotes; Nucleocytoplasmic transport; Influenza A; Human T-cell leukemia virus 1 infection","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; MAPK6/MAPK4 signaling; Deactivation of the beta-catenin transactivating complex; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Heme signaling; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Downregulation of TGF-beta receptor signaling; HuR (ELAVL1) binds and stabilizes mRNA; Cyclin A/B1/B2 associated events during G2/M transition","eIF5A regulation in response to inhibition of the nuclear export system; 22q11.2 copy number variation syndrome",17814.1,17755.8,17644.7,16609.7,15939.8,14510.8,1.13077477194153,0.1773116015105442,0.02983117343579884,1.5253296629413546,0.17154685022993998,0.7656172516113899,1271]
["O14981","TATA-binding protein-associated factor 172 [OS=Homo sapiens]",15,20,44,20,1849,206.8,6.52,146.79,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","BTAF1","ENSG00000095564","","","",3220.2,3132.4,3133.6,3293.8,3497.7,3862.9,0.8903551584321971,-0.16754715981816953,0.08254844955605602,1.0832910793433175,0.28567548191534725,0.5441270313211193,2112]
["O14986","Phosphatidylinositol 4-phosphate 5-kinase type-1 beta [OS=Homo sapiens]",5,2,3,1,540,61,6.86,6.4,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","kinase activity;other molecular function","PIP5K1B","ENSG00000107242","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Phospholipase D signaling pathway; Endocytosis; Focal adhesion; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Yersinia infection; Choline metabolism in cancer","Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; WNT mediated activation of DVL","B cell receptor signaling pathway; Wnt signaling pathway; Regulation of actin cytoskeleton",38.3,34.2,40.3,40,37.5,56.3,0.8430493273542601,-0.2463110482426674,0.3193837452593186,0.4956871906515717,0.5352845205458289,0.2714153154410252,4361]
["O15014","zinc finger protein 609 [OS=Homo sapiens]",1,1,1,1,1411,151.1,8.03,2.25,"developmental processes;other biological processes","nucleus","other molecular function","ZNF609","ENSG00000180357","","","",111.7,120.8,119,191,173.3,185.5,0.6393233903237542,-0.6453822175530555,3.6723491366677497E-4,3.435056036370515,0.021134803023546915,1.6750017954424987,127]
["O15015","Zinc finger protein 646 [OS=Homo sapiens]",1,1,1,1,1829,200.6,7.33,3.44,"","","","","","","","",101.3,95.2,105.4,117.5,116.3,257.6,0.6143671143671143,-0.7028271008485397,0.2500818623424677,0.6019178051516414,0.4798761700869248,0.3188708159286147,3809]
["O15020","Spectrin beta chain, non-erythrocytic 2 [OS=Homo sapiens]",13,30,70,16,2390,271.2,6.11,202.36,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SPTBN2","ENSG00000173898","Spinocerebellar ataxia; Pathways of neurodegeneration","MHC class II antigen presentation; COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins","",946.2,876.7,888.6,907,941.9,2017.4,0.7013165041512558,-0.511862415390609,0.351192351469665,0.4544549510537776,0.5524892158613391,0.2576761946340212,4646]
["O15027-5","Isoform 5 of Protein transport protein Sec16A [OS=Homo sapiens]",22,34,83,34,2201,235.6,5.67,232.92,"","","","","","","","",7488.5,7239.5,7030.9,7680.2,7940.7,10692,0.8269289968038491,-0.27416463532952373,0.19356048934033537,0.7131832886220064,0.4277997026273091,0.3687595216517363,3307]
["O15031","Plexin-B2 [OS=Homo sapiens]",6,10,18,9,1838,205,6.24,46.43,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","PLXNB2","ENSG00000196576","Axon guidance","","",805.2,810,777.5,748.7,678.7,1592.7,0.7922585344856129,-0.3359567989813341,0.5159841198619057,0.28736366419153336,0.659553678221523,0.1807498533295305,5718]
["O15037","protein KHNYN [OS=Homo sapiens]",7,4,4,4,678,74.5,7.02,12.78,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KHNYN","ENSG00000100441","","","",324.9,307.2,334.8,320.6,326.6,443.7,0.8863323861032173,-0.17408026534383947,0.3691231423214358,0.4328287256864106,0.5651279948109288,0.2478531784731734,4774]
["O15042-2","Isoform 2 of U2 snRNP-associated SURP motif-containing protein [OS=Homo sapiens]",31,24,78,1,1028,118.2,8.47,207.63,"","","","U2SURP","","","","",7083.4,6866.2,6665.6,7732.4,7754.8,5273.8,0.9929772168970665,-0.010167478288489733,0.9562254350547666,0.019439708499445006,0.9742196410392095,0.011343118955419841,7174]
["O15047","Histone-lysine N-methyltransferase SETD1A [OS=Homo sapiens]",6,8,12,8,1707,185.9,5.14,36.58,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SETD1A","ENSG00000099381","Lysine degradation; Metabolic pathways","PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","Histone modifications",656,646.2,694.8,645.7,674.9,1386.3,0.7377442831283019,-0.43880725880907606,0.3845921033518176,0.4149996371696626,0.5720357516073331,0.24257682742975173,4914]
["O15050","TPR and ankyrin repeat-containing protein 1 [OS=Homo sapiens]",1,1,1,1,2925,336,6.76,0,"","","","TRANK1","ENSG00000168016","","","",29.8,31.8,27.9,30.9,24.4,35.5,0.9856828193832599,-0.020804615139296292,0.9050416062964568,0.043331455082512564,0.9401576322371806,0.026799323983963244,7036]
["O15056","Synaptojanin-2 [OS=Homo sapiens]",3,4,4,4,1496,165.4,7.34,11.76,"cell organization and biogenesis;other metabolic processes;transport;developmental processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity;other molecular function","SYNJ2","ENSG00000078269","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane","",354.6,391.9,344.1,394.9,354,683.2,0.761538998673277,-0.39301017537520894,0.3376630022134962,0.47151652247022097,0.5449279936362208,0.26366088126920517,4529]
["O15061-1","Synemin [OS=Homo sapiens]",4,5,5,5,1565,172.7,5.16,13.83,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SYNM","ENSG00000182253","","","",164.4,168.6,170.7,159.9,165.8,252.1,0.871754932502596,-0.1980054729064294,0.45456621089078963,0.34240284966925155,0.6143536308063575,0.2115815707188581,5408]
["O15062","zinc finger and BTB domain-containing protein 5 [OS=Homo sapiens]",2,1,1,1,677,74.2,6.19,3.91,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB5","ENSG00000168795","","","",52.4,43.8,47.3,54.3,63.8,123.1,0.5949419568822555,-0.7491791703370344,0.2072974707698033,0.6834059966877061,0.4432818062774992,0.35332009318845115,3418]
["O15066","Kinesin-like protein KIF3B [OS=Homo sapiens]",18,11,14,9,747,85.1,7.69,41.08,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF3B","ENSG00000101350","","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins","",1189.7,1235.6,1117.2,1330.2,1336.7,1117.4,0.9361044314668497,-0.09525860957111491,0.3699468537967621,0.43186066177253274,0.5656781494561787,0.2474305965006787,4780]
["O15067","Phosphoribosylformylglycinamidine synthase [OS=Homo sapiens]",33,35,110,35,1338,144.6,5.76,331.34,"other metabolic processes;other biological processes","cytosol","other molecular function","PFAS","ENSG00000178921","Purine metabolism; Metabolic pathways","Purine ribonucleoside monophosphate biosynthesis","",13504.7,13630.5,13555.6,12803.2,13171.3,14186.5,1.013191902592067,0.01890745222133197,0.6925049599351282,0.1595771117007085,0.790491762012471,0.10210265164090318,6403]
["O15078-1","Centrosomal protein of 290 kDa [OS=Homo sapiens]",1,2,4,2,2479,290.2,5.95,10.65,"cell organization and biogenesis;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","CEP290","ENSG00000198707","","Neutrophil degranulation; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","Clear cell renal cell carcinoma pathways; Ciliary landscape; Joubert syndrome; Ciliopathies",1094.9,1024.1,1124.2,1358.8,1425.2,1782.5,0.7102157013029672,-0.4936708393700303,0.030782659155290177,1.5116938664218058,0.17373780368032116,0.7601056729551035,1295]
["O15084","serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A [OS=Homo sapiens]",14,11,22,9,1053,112.9,6.25,80.85,"","cytosol;nucleus","","ANKRD28","ENSG00000206560","","Telomere Extension By Telomerase; COPII-mediated vesicle transport","",1459.6,1444.9,1399,1468.1,1427.2,1690.3,0.9384813328681088,-0.09160004588496291,0.3243786820514269,0.4889476950639879,0.5379813449316722,0.26923278368993386,4407]
["O15085-1","Rho guanine nucleotide exchange factor 11 [OS=Homo sapiens]",1,2,2,2,1522,167.6,5.5,5.16,"cell organization and biogenesis;signal transduction;other biological processes","other membranes;cytosol;other cell component","signal transduction activity or receptor binding;enzyme regulator activity","ARHGEF11","ENSG00000132694","Vascular smooth muscle contraction; Parathyroid hormone synthesis, secretion and action; Pathogenic Escherichia coli infection; Human cytomegalovirus infection; Pathways in cancer","RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOB GTPase cycle; Sema4D induced cell migration and growth-cone collapse","",152.2,166.9,158,161.6,166.3,260.6,0.8107051826677996,-0.3027507289415015,0.31731919380638535,0.4985036577700872,0.5343976929794633,0.27213542539862495,4340]
["O15091","Mitochondrial ribonuclease P protein 3 [OS=Homo sapiens]",19,10,14,10,583,67.3,8.78,42.78,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus","other molecular function","PRORP","ENSG00000100890","","tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion","",1225.1,1346.3,1399.7,1204.9,1384.1,807.2,1.1692774277133267,0.22561727041766327,0.3425653391969508,0.4652565811165938,0.547639996542107,0.26150484095586496,4572]
["O15111","Inhibitor of nuclear factor kappa-B kinase subunit alpha [OS=Homo sapiens]",8,4,5,4,745,84.6,6.73,16.69,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","CHUK","ENSG00000213341","Antifolate resistance; MAPK signaling pathway; Ras signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; FoxO signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; TNF signaling pathway; Adipocytokine signaling pathway; Alcoholic liver disease; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Chagas disease; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Chemical carcinogenesis; Pancreatic cancer; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Constitutive Signaling by AKT1 E17K in Cancer; IKK complex recruitment mediated by RIP1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; AKT phosphorylates targets in the cytosol","Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Canonical and non-canonical Notch signaling; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Chemokine signaling pathway; IL-4 signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNAs involvement in the immune response in sepsis; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - interferon induction; Neuroinflammation; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; T-cell receptor (TCR) signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway",361,346.3,315.5,363.1,333.5,503.5,0.8522623114740439,-0.23063055971925558,0.33619584437047545,0.4734076590646782,0.544483808221539,0.26401503070085103,4513]
["O15116","U6 snRNA-associated Sm-like protein LSm1 [OS=Homo sapiens]",35,4,6,4,133,15.2,5.22,15.68,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","LSM1","ENSG00000175324","RNA degradation","mRNA decay by 5' to 3' exoribonuclease","",447,418,477.1,558.2,546.3,1157.9,0.5932195898161244,-0.7533618543707442,0.20461005336239615,0.689073031364091,0.4406290159180181,0.3559269074617751,3394]
["O15118","Niemann-Pick C1 protein [OS=Homo sapiens]",4,5,16,5,1278,142.1,5.36,47.77,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","NPC1","ENSG00000141458","Lysosome; Cholesterol metabolism","LDL clearance","Irinotecan pathway; Irinotecan pathway; Irinotecan pathway; Ebola virus pathway in host; Irinotecan pathway; Irinotecan pathway",1391.9,1371.7,1409.9,1239.9,1277.1,1189.6,1.1259644957643125,0.17116133666119895,4.9006044137321E-3,2.3097503531631776,0.07280186516253642,1.1378574940465649,492]
["O15121","Sphingolipid delta(4)-desaturase DES1 [OS=Homo sapiens]",5,1,4,1,323,37.8,7.46,17.04,"cell organization and biogenesis;other metabolic processes;developmental processes","plasma membrane;other membranes;mitochondrion;ER/Golgi","other molecular function","DEGS1","ENSG00000143753","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway","Neutrophil degranulation; Sphingolipid de novo biosynthesis","Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway; Sphingolipid metabolism in senescence",252.5,240.6,261.2,240.3,276.3,244.9,0.9905449770190412,-0.013705610788111526,0.8602942070262407,0.06535300150357594,0.90839213509893,0.041726634577711856,6922]
["O15126-1","Secretory carrier-associated membrane protein 1 [OS=Homo sapiens]",12,4,6,4,338,37.9,7.42,21.87,"transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","SCAMP1","ENSG00000085365","","Neutrophil degranulation","",783.9,706.4,728.5,827.5,964.6,1194.7,0.7428686219365207,-0.42882100557683994,0.07971073175399435,1.0984832039767827,0.27956129481283337,0.5535229567202965,2084]
["O15127","Secretory carrier-associated membrane protein 2 [OS=Homo sapiens]",16,5,25,5,329,36.6,6.1,97.67,"transport","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","SCAMP2","ENSG00000140497","","","Serotonin transporter activity; Monoamine transport",2392.8,2117.2,2049.2,2190,2172.4,2220.4,0.996414899434891,-0.005181500466262217,0.9443938283905864,0.024846859696519674,0.9670180010796856,0.014565441432188339,7138]
["O15143","Actin-related protein 2/3 complex subunit 1B [OS=Homo sapiens]",51,17,75,16,372,40.9,8.35,254.53,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","ARPC1B","ENSG00000130429","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling","Pathogenic Escherichia coli infection; Microglia pathogen phagocytosis pathway",13534.3,13307,13011.6,12658,12872.7,9442.8,1.1395170629190674,0.18842252741533697,0.21992806755348746,0.6577193417818178,0.45459678895600675,0.3423736362388803,3536]
["O15144","Actin-related protein 2/3 complex subunit 2 [OS=Homo sapiens]",67,19,142,19,300,34.3,7.36,398.24,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity","ARPC2","ENSG00000163466","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling","Pathogenic Escherichia coli infection",20634.9,22525.7,22990.4,19720,17620.2,12857.7,1.3178041312485185,0.3981359546588523,0.06904580483809988,1.1608627036315105,0.26026600699415786,0.5845825508262429,1939]
["O15145","Actin-related protein 2/3 complex subunit 3 [OS=Homo sapiens]",31,6,26,6,178,20.5,8.59,47.95,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity","ARPC3","ENSG00000111229","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection","Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling","Pathogenic Escherichia coli infection",2038.8,1623.4,2105.7,2440.7,3381.1,1933.8,0.7437077724482954,-0.4271922451376762,0.2149358451744052,0.6676911505240117,0.4502625658869956,0.3465341580881496,3489]
["O15155","BET1 homolog [OS=Homo sapiens]",51,3,4,3,118,13.3,9.06,15.06,"cell organization and biogenesis;transport","other membranes;ER/Golgi","other molecular function","BET1","ENSG00000105829","SNARE interactions in vesicular transport","COPI-mediated anterograde transport; COPII-mediated vesicle transport","",230.4,220.4,228.9,209,215.8,338.3,0.8907089503341633,-0.16697400377434793,0.5453809992300247,0.2632999967084645,0.6803532553972096,0.16726553283200832,5859]
["O15156","Zinc finger and BTB domain-containing protein 7B [OS=Homo sapiens]",5,1,1,1,539,58,5.86,3.39,"RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZBTB7B","ENSG00000160685","","","Ectoderm differentiation; Ectoderm differentiation",20.3,21.2,18.3,14.9,15,26.6,1.0584070796460179,0.08189461689555522,0.7957922703131746,0.09920028355685655,0.8634865949701593,0.06374440016447665,6736]
["O15160","DNA-directed RNA polymerases I and III subunit RPAC1 [OS=Homo sapiens]",37,9,25,9,346,39.2,5.5,78.2,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR1C","ENSG00000171453","RNA polymerase; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","Pyrimidine metabolism; Cytosolic DNA-sensing pathway",1471.1,1475.3,1520.5,1537.9,1599.4,1806.7,0.9034991909385112,-0.14640478569513032,0.12728958572513002,0.8952071269600475,0.35321168643317213,0.45196493570183943,2634]
["O15162","phospholipid scramblase 1 [OS=Homo sapiens]",3,1,1,1,318,35,4.94,2.06,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","extracellular matrix;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;transporter activity;nucleic acid binding activity;other molecular function","PLSCR1","ENSG00000188313","","","EGF/EGFR signaling pathway; Complement system in neuronal development and plasticity",25.7,36.1,32.7,35.3,25.5,18.6,1.1901763224181359,0.25117532196547704,0.4294128700871071,0.3671249433090614,0.5988511099917316,0.22268114112768186,5241]
["O15164","Transcription intermediary factor 1-alpha [OS=Homo sapiens]",14,10,14,9,1050,116.8,7.11,36.53,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;kinase activity;other molecular function","TRIM24","ENSG00000122779","","Signaling by BRAF and RAF1 fusions; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease","",1131.8,1077.2,1073.6,1138,1105.9,2018.8,{"$f":"AVERAGE(S258:U258)/AVERAGE(V258:X258)","v":0.7700753043845451},{"$f":"LOG(Y258,2)","v":-0.37692856343041686},{"$f":"TTEST(V258:X258,S258:U258,2,2)","v":0.3369220603048552},0.4724705522275203,{"$f":"AA258*7309/AE258","v":0.5446943903490792},0.26384709737784157,4521]
["O15173","Membrane-associated progesterone receptor component 2 [OS=Homo sapiens]",49,13,55,11,223,23.8,4.88,196.01,"transport;developmental processes;signal transduction","other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","PGRMC2","ENSG00000164040","","RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle","Ciliary landscape",5913.6,5678.6,5781,5516.9,5889.3,6640.6,0.9626748232373604,-0.05487953474859438,0.542156199242761,{"$f":"-LOG10(AA259)","v":0.2658755719557575},0.6782984697475762,{"$f":"-LOG10(AC259)","v":0.16857916270931547},5842]
["O15182","Centrin-3 [OS=Homo sapiens]",15,3,3,3,167,19.5,4.74,7.09,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","CETN3","ENSG00000153140","","","Breast cancer pathway",208.1,224.1,242.9,397.5,471.3,230.9,0.6138946985541511,-0.7039368837580755,0.12003187824483164,0.9207033980587683,0.3444495477390948,0.4628743811384104,2547]
["O15211","Ral guanine nucleotide dissociation stimulator-like 2 [OS=Homo sapiens]",3,2,2,2,777,83.5,6.18,5.85,"signal transduction;other biological processes","cytosol","enzyme regulator activity","RGL2","ENSG00000206282; ENSG00000224841; ENSG00000228736; ENSG00000237441; ENSG00000237825","Ras signaling pathway","RAF/MAP kinase cascade","Ras signaling",138.6,150.4,125.5,153.2,163.6,520.7,0.4949253731343283,-1.0147170887367472,0.3087155070260472,0.5104415550119193,0.5275664346161746,0.27772284338475756,4277]
["O15213","WD repeat-containing protein 46 [OS=Homo sapiens]",21,11,15,11,610,68,9.67,46.35,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","WDR46","ENSG00000204221; ENSG00000206284; ENSG00000226916; ENSG00000227057; ENSG00000236222","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",838.1,861.8,845.8,1603.9,1703,2132.8,0.467985366840083,-1.0954646751583792,4.0346651840459605E-3,2.3941924992949426,0.06702129052316347,1.1737872138971572,440]
["O15226","NF-kappa-B-repressing factor [OS=Homo sapiens]",32,22,55,22,690,77.6,8.79,152.72,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","NKRF","ENSG00000186416","","","Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Network map of SARS-CoV-2 signaling pathway",5434.8,5068,5050.5,5878.1,5708.8,5687.8,0.9003513809212316,-0.1514399416910838,0.014522066894840206,1.837971567028413,0.12299164187066866,0.9101244008596495,863]
["O15228","Dihydroxyacetone phosphate acyltransferase [OS=Homo sapiens]",23,14,32,14,680,77.1,6.57,82.48,"cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;other cytoplasmic organelle","other molecular function","GNPAT","ENSG00000116906","Glycerophospholipid metabolism; Peroxisome","Peroxisomal protein import; Plasmalogen biosynthesis; Synthesis of PA","Triacylglyceride synthesis",3492.6,3467.6,3443.9,3477.7,2936.5,2952.2,1.1107896310215237,0.15158561508930352,0.12452829410311128,0.9047319612046362,0.3497991166793391,0.4561812915462306,2602]
["O15229","Kynurenine 3-monooxygenase [OS=Homo sapiens]",8,3,4,3,486,55.8,9.03,13.58,"other metabolic processes;stress response;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion","other molecular function","KMO","ENSG00000117009","Tryptophan metabolism; Metabolic pathways; Biosynthesis of cofactors","Tryptophan catabolism","Selenium micronutrient network; NAD biosynthesis II (from tryptophan)",248.6,237.9,245.2,243,241.8,478.7,0.7594187856772184,-0.3970324076657434,0.3825033884211347,0.41736471327877367,0.5704381281310086,0.24379145390743037,4901]
["O15230","Laminin subunit alpha-5 [OS=Homo sapiens]",0,1,1,1,3695,399.5,7.02,3.56,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;other cell component","signal transduction activity or receptor binding;extracellular structural activity","LAMA5","ENSG00000130702","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Toxoplasmosis; Amoebiasis; Human papillomavirus infection; Pathways in cancer; Small cell lung cancer","Degradation of the extracellular matrix; ECM proteoglycans; Non-integrin membrane-ECM interactions; Interleukin-4 and Interleukin-13 signaling; Laminin interactions; MET activates PTK2 signaling","Alpha 6 beta 4 signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Complement system; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Inflammatory response pathway; Small cell lung cancer; Malignant pleural mesothelioma",17.6,13.9,15.7,14.3,20.3,64.6,0.4758064516129033,-1.0715532610250338,0.3368518518455221,0.47256106076764576,0.5447013683935665,0.2638415336950549,4520]
["O15234","Protein CASC3 [OS=Homo sapiens]",17,9,11,9,703,76.2,6.48,19.86,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","CASC3","ENSG00000108349","Nucleocytoplasmic transport; mRNA surveillance pathway","Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","",1370.5,1375.7,1320.2,2220.8,2193.9,2484.5,0.5894016697588125,-0.7626769473040614,5.6100029695096412E-4,3.251036908861252,0.025310809693917264,1.59669396151991,162]
["O15235","28S ribosomal protein S12, mitochondrial [OS=Homo sapiens]",30,3,14,3,138,15.2,10.29,40.07,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPS12","ENSG00000128626; ENSG00000283018","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1469.9,1437.3,1438.6,1434.4,1475.1,1304.3,1.0313256443115475,0.04449994013015793,0.44992431733902927,0.34686053361648594,0.6114720779901385,0.2136233696197958,5378]
["O15243","Leptin receptor gene-related protein [OS=Homo sapiens]",17,2,4,2,131,14.2,6.51,9.3,"transport;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","signal transduction activity or receptor binding","LEPROT","ENSG00000213625","","","",356.4,380.7,392.9,398.2,378.5,603.9,0.8184847167898016,-0.28897261675533326,0.3155633539538232,0.5009134367037733,0.5332838275256633,0.2730415866206334,4325]
["O15247","Chloride intracellular channel protein 2 [OS=Homo sapiens]",57,13,57,11,247,28.3,5.59,218.71,"other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","transporter activity;other molecular function","CLIC2","ENSG00000155962","","Stimuli-sensing channels; Ion homeostasis","",3123.4,2854,3145.8,3318.9,3663.7,3649.4,0.8580887885628293,-0.22080116022558396,0.026487401359486087,1.5769606476142553,0.1605277085708821,0.7944499935344148,1206]
["O15254","Peroxisomal acyl-coenzyme A oxidase 3 [OS=Homo sapiens]",24,12,20,12,700,77.6,7.25,66.46,"other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle","other molecular function","ACOX3","ENSG00000087008","Fatty acid degradation; beta-Alanine metabolism; alpha-Linolenic acid metabolism; Propanoate metabolism; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Carbon metabolism; Fatty acid metabolism; PPAR signaling pathway; cAMP signaling pathway; Peroxisome; Alcoholic liver disease","Peroxisomal protein import; Beta-oxidation of pristanoyl-CoA","PPAR signaling pathway; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Omega-3 / omega-6 fatty acid synthesis",1229.7,1192.7,1070.3,1130.5,1084.8,1461.4,0.9499551228003371,-0.07406873475186052,0.6569757660486069,0.1824506500223727,0.7614709600458718,0.1183466545502856,6306]
["O15258","Protein RER1 [OS=Homo sapiens]",24,4,18,4,196,22.9,9.54,56.74,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding","RER1","ENSG00000157916","","","",2584,2403.9,2425.8,2359.5,2446.1,1686.1,1.1420275120538532,0.19159740641490644,0.28102203906960876,0.5512596193440709,0.5059088875762981,0.295927691037292,4060]
["O15260-1","surfeit locus protein 4 [OS=Homo sapiens]",21,5,34,5,269,30.4,7.78,61.06,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","","SURF4","ENSG00000148248; ENSG00000280951; ENSGGOG00000014456; ENSNLEG00000013096; ENSPTRG00000021519","","COPI-dependent Golgi-to-ER retrograde traffic; Neutrophil degranulation","",2535.2,2776.7,2809.4,2093.7,2134.9,1342.3,1.4578075355867093,0.5438002630235138,0.035233832869542014,1.4530401100532664,0.1842089302170834,0.7346893195789561,1398]
["O15264","Mitogen-activated protein kinase 13 [OS=Homo sapiens]",28,7,19,6,365,42.1,8.38,64.93,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","MAPK13","ENSG00000156711","Endocrine resistance; MAPK signaling pathway; Rap1 signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Oocyte meiosis; Cellular senescence; Adrenergic signaling in cardiomyocytes; VEGF signaling pathway; Osteoclast differentiation; Signaling pathways regulating pluripotency of stem cells; Platelet activation; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; TNF signaling pathway; Leukocyte transendothelial migration; Thermogenesis; Neurotrophin signaling pathway; Retrograde endocannabinoid signaling; Dopaminergic synapse; Inflammatory mediator regulation of TRP channels; GnRH signaling pathway; Progesterone-mediated oocyte maturation; Prolactin signaling pathway; Relaxin signaling pathway; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Alcoholic liver disease; Amyotrophic lateral sclerosis; Prion disease; Pathways of neurodegeneration; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Yersinia infection; Leishmaniasis; Chagas disease; Toxoplasmosis; Tuberculosis; Hepatitis B; Human cytomegalovirus infection; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Proteoglycans in cancer; Chemical carcinogenesis; PD-L1 expression and PD-1 checkpoint pathway in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","VEGFA-VEGFR2 Pathway; NOD1/2 Signaling Pathway; p38MAPK events; DSCAM interactions","Regulation of toll-like receptor signaling pathway; Parkinson's disease pathway; Retinoblastoma gene in cancer; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Angiopoietin-like protein 8 regulatory pathway; Oxidative damage response; Epithelial to mesenchymal transition in colorectal cancer; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Regulatory circuits of the STAT3 signaling pathway; Hepatitis B infection; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - apoptosis; Host-pathogen interaction of human coronaviruses - MAPK signaling; Toll-like receptor signaling pathway",1546.8,1504.6,1479.2,1598.6,1390.7,1556.8,0.9965904841512503,-0.004927296235517017,0.941785750536253,0.0260478848322342,0.9655648829666815,0.015218537661251004,7129]
["O15269","serine palmitoyltransferase 1 [OS=Homo sapiens]",18,8,16,8,473,52.7,6.01,50.1,"other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","SPTLC1","ENSG00000090054","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway","Sphingolipid de novo biosynthesis","Sphingolipid pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway",1106.1,1184,1219.4,1210.2,1157.6,1512.7,0.904393763690246,-0.14497705096706617,0.3449656037401843,0.46222420594279817,0.5487167786152355,0.2606517597809553,4595]
["O15270","Serine palmitoyltransferase 2 [OS=Homo sapiens]",11,5,12,5,562,62.9,7.78,29.59,"other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","SPTLC2","ENSG00000100596","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway","Sphingolipid de novo biosynthesis","Sphingolipid pathway; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway",579.9,580.9,545.3,586.7,582.6,993.7,0.78876560332871,-0.34233145517595315,0.3281417822161242,0.4839384674786092,0.5402992309568939,0.26736565062000284,4439]
["O15287","Fanconi anemia group G protein [OS=Homo sapiens]",2,1,1,1,622,68.5,5.47,2.22,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus","nucleic acid binding activity","FANCG","ENSG00000221829","Fanconi anemia pathway","Fanconi Anemia Pathway","Retinoblastoma gene in cancer; DNA repair pathways, full network",26.8,27.7,31.3,26.2,31.8,37,0.903157894736842,-0.1469498657187647,0.41907918602930966,0.377703908283523,0.5929248491459977,0.22700034823684845,5166]
["O15294","UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit [OS=Homo sapiens]",12,12,22,12,1046,116.9,6.7,62.76,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component","other molecular function","OGT","ENSG00000147162","Other types of O-glycan biosynthesis; Insulin resistance","UCH proteinases; Regulation of necroptotic cell death; HATs acetylate histones","Ectoderm differentiation; Ectoderm differentiation",2541,2559.2,2492.5,3685.8,3531.2,4889.2,0.6271745056252168,-0.6730611791772547,0.024865088983819304,1.6044099822345894,0.155999086165438,0.8068779457126543,1165]
["O15297","protein phosphatase 1D [OS=Homo sapiens]",7,3,3,3,605,66.6,8.94,10.35,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus","kinase activity;other molecular function","PPM1D","ENSG00000170836","p53 signaling pathway","Transcriptional regulation by RUNX2","ATM signaling in development and disease ; Genotoxicity pathway",139.1,167.9,154.8,139.4,134.1,768.7,0.4431011322203032,-1.174292081657434,0.4107091690472043,0.3864656014508152,0.5881413237786082,0.23051830527994813,5104]
["O15305","Phosphomannomutase 2 [OS=Homo sapiens]",44,12,65,11,246,28.1,6.77,167.72,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","PMM2","ENSG00000140650","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars","Defective PMM2 causes PMM2-CDG (CDG-1a); Synthesis of GDP-mannose","Nephrotic syndrome",7858.1,7590.5,7829.1,8350,8145.3,7184.9,0.9830026773422523,-0.024732748938871587,0.734573221080186,0.13396490793884522,0.8193187353693087,0.0865471140110109,6553]
["O15315-1","Isoform 2 of DNA repair protein RAD51 homolog 2 [OS=Homo sapiens]",3,1,1,1,350,38.2,6.1,2.84,"","","","RAD51B","","","","",23.7,23.4,30,28.4,18.4,95.2,0.5429577464788732,-0.8810881644770102,0.42192661553872485,0.37476307803831915,0.5938497271273907,0.2263234387494025,5193]
["O15320","Endoplasmic reticulum export factor CTAGE5 [OS=Homo sapiens]",31,22,47,22,804,90.9,5.22,160.23,"","","","","","","","",5573.7,5538.7,5642.3,5428.3,5866.5,4146.1,1.0850857139156398,0.11780900963456165,0.4447207294755158,0.3519126265955727,0.6083593134449832,0.21583983889450567,5343]
["O15321-1","Transmembrane 9 superfamily member 1 [OS=Homo sapiens]",5,2,3,2,606,68.8,7.17,10.15,"other metabolic processes;other biological processes","other membranes;other cytoplasmic organelle;other cell component","","TM9SF1","ENSCANG00000029500; ENSCCAG00000032112; ENSG00000100926; ENSG00000285465; ENSPPAG00000042444; ENSPTRG00000032568; ENSRBIG00000029944; ENSRROG00000042511","","","",288.3,282.9,262.8,303.7,288.8,221.4,1.0246959085882785,0.035195835329003486,0.8127236941896122,0.09005707861827926,0.8760061172145518,0.05749286111131588,6781]
["O15344-1","E3 ubiquitin-protein ligase Midline-1 [OS=Homo sapiens]",10,6,6,6,667,75.2,6.8,19.65,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","MID1","ENSCANG00000031338; ENSCCAG00000029160; ENSCJAG00000000987; ENSCSAG00000015273; ENSG00000101871; ENSMFAG00000037182; ENSMLEG00000034816; ENSMMUG00000020179; ENSMNEG00000026727; ENSPANG00000006683; ENSPPAG00000038224; ENSRBIG00000037000; ENSTSYG00000003295","Ubiquitin mediated proteolysis","Interferon gamma signaling","",367.4,367.8,379.4,346.4,354.8,455.9,0.9632702445769596,-0.05398749327181245,0.7094924932171074,0.14905219523347557,0.8014962338367602,0.09609851401820298,6470]
["O15347","High mobility group protein B3 [OS=Homo sapiens]",23,4,6,3,200,23,8.37,19.09,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","HMGB3","ENSG00000029993","","","",535.5,557.3,451,480.5,412.6,797.5,0.9131669229859223,-0.13104949212329353,0.7109928946058874,0.14813473942336183,0.8020754849011316,0.09578475748471554,6479]
["O15355","Protein phosphatase 1G [OS=Homo sapiens]",51,23,124,23,546,59.2,4.36,418.89,"protein metabolism;other metabolic processes;other biological processes","other membranes;nucleus;other cell component","other molecular function","PPM1G","ENSG00000115241","","","VEGFA-VEGFR2 signaling pathway; mRNA processing",16728.1,16397.3,16023.8,16651.6,18717.2,16347.2,0.9503673911362053,-0.0734427594359425,0.32975782664780157,0.48180488788284337,0.541496282850771,0.26640452028139294,4451]
["O15357","Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 [OS=Homo sapiens]",25,21,39,20,1258,138.5,6.54,114.09,"cell adhesion;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","INPPL1","ENSG00000165458","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; B cell receptor signaling pathway; Fc gamma R-mediated phagocytosis; Insulin signaling pathway","Synthesis of PIPs at the plasma membrane; Interleukin receptor SHC signaling; Synthesis of IP3 and IP4 in the cytosol","EGF/EGFR signaling pathway; Insulin signaling",2890.2,2819.4,2770.1,2912.5,2956.6,3269,0.9279500114903537,-0.10788100517829742,0.1351659209133725,0.8691327923064011,0.3612167151575282,0.4422321610918778,2735]
["O15360","Fanconi anemia group A protein [OS=Homo sapiens]",2,2,2,2,1455,162.7,6.6,5.6,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","","FANCA","ENSG00000187741","Fanconi anemia pathway","Fanconi Anemia Pathway","DNA repair pathways, full network",163.2,133.7,132.8,164.3,174.6,214.2,0.7768938709094196,-0.36421056494198667,0.08662183639651709,1.0623726133974494,0.29297501259701225,0.5331694183967176,2161]
["O15371","Eukaryotic translation initiation factor 3 subunit D [OS=Homo sapiens]",58,23,96,23,548,63.9,6.05,317.05,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity","EIF3D","ENSG00000100353","","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","Translation factors; VEGFA-VEGFR2 signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell",8028.7,8204.5,8045.6,8291.1,8385.6,6068.7,1.0674158291346822,0.09412231089715796,0.5376376332527814,0.2695103393924944,0.675303911573222,0.17050073470193228,5819]
["O15372","Eukaryotic translation initiation factor 3 subunit H [OS=Homo sapiens]",53,18,89,18,352,39.9,6.54,252.59,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3H","ENSG00000147677","Measles","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","Translation factors; VEGFA-VEGFR2 signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell",10913,10890,11237.8,11781.7,11401.3,13680.3,0.8963060822009966,-0.15793660828962536,0.1487901890811867,0.8274257043302949,0.3794513230964388,0.4208439285076476,2866]
["O15379","Histone deacetylase 3 [OS=Homo sapiens]",11,5,13,5,428,48.8,5.16,34.32,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","HDAC3","ENSG00000171720","Neutrophil extracellular trap formation; Thyroid hormone signaling pathway; Alcoholism; Viral carcinogenesis","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Regulation of PTEN gene transcription; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Cytoprotection by HMOX1; Association of TriC/CCT with target proteins during biosynthesis; NR1D1 (REV-ERBA) represses gene expression; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RUNX2 regulates osteoblast differentiation; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; STAT3 nuclear events downstream of ALK signaling","Neural crest differentiation; Initiation of transcription and translation elongation at the HIV-1 LTR; Ethanol effects on histone modifications; Transcription co-factors SKI and SKIL protein partners; 22q11.2 copy number variation syndrome; IL-18 signaling pathway; 7q11.23 copy number variation syndrome; 16p11.2 proximal deletion syndrome",1327.4,1335.4,1385.1,1539.3,1480,1855,0.8304577067476355,-0.26802139788469603,0.07946959097160473,1.0997990222823661,0.2793858780237898,0.5537955497298623,2079]
["O15381-1","Nuclear valosin-containing protein-like [OS=Homo sapiens]",26,17,29,17,856,95,6.48,88.47,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","NVL","ENSG00000143748","Ribosome biogenesis in eukaryotes","","",2108.7,2059,2139.4,2484.4,2531,3403.3,0.7491774264435126,-0.41662066467190206,0.07867368159893284,1.1041705261917478,0.2780589646066732,0.5558630987296799,2068]
["O15382","Branched-chain-amino-acid aminotransferase, mitochondrial [OS=Homo sapiens]",49,14,34,14,392,44.3,8.65,113.66,"other metabolic processes;other biological processes","mitochondrion","other molecular function","BCAT2","ENSG00000105552","Cysteine and methionine metabolism; Valine, leucine and isoleucine degradation; Valine, leucine and isoleucine biosynthesis; Pantothenate and CoA biosynthesis; Metabolic pathways; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids; Biosynthesis of cofactors","Branched-chain amino acid catabolism","One-carbon metabolism and related pathways",4592.4,4704.8,4927.2,3826.9,4035.9,4161,1.1830203429864106,0.24247488219272462,0.00609811074786678,2.2148046926714127,0.08059871872723018,1.0936718620921382,553]
["O15397-1","Importin-8 [OS=Homo sapiens]",10,8,19,7,1037,119.9,5.16,63.01,"transport;signal transduction","cytosol;nucleus","other molecular function","IPO8","ENSG00000133704","Nucleocytoplasmic transport","Transcriptional regulation by small RNAs","",1003.3,973.7,989.6,1148.4,1290,1524.3,0.7486309839251016,-0.41767333594943173,0.039158701574274445,1.4071717169832145,0.19390985759239288,0.7124001125862642,1476]
["O15400","Syntaxin-7 [OS=Homo sapiens]",62,11,84,11,261,29.8,5.55,223.5,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","STX7","ENSG00000079950","SNARE interactions in vesicular transport; Phagosome","","",4433,4061.7,3964.1,4546.6,5216.7,6621.1,0.7604062400820292,-0.395157723739325,0.10546784560680571,0.9768799252385063,0.32172975106015983,0.4925087770718071,2396]
["O15427","Monocarboxylate transporter 4 [OS=Homo sapiens]",3,2,4,2,465,49.4,7.96,10.11,"transport","plasma membrane;other membranes;nucleus;other cell component","transporter activity","SLC16A3","ENSG00000141526","Central carbon metabolism in cancer","Pyruvate metabolism; Basigin interactions; Proton-coupled monocarboxylate transport","Metabolic reprogramming in colon cancer",584.4,581.8,509.2,476.6,468.5,567.5,1.1076292476530476,0.1474750545983638,0.24819319901311415,0.6052101232061179,0.47826103126465896,0.3203350040249354,3793]
["O15439-1","multidrug resistance-associated protein 4 [OS=Homo sapiens]",8,7,13,6,1325,149.4,8.19,35.69,"cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes","transporter activity;other molecular function","ABCC4","ENSG00000125257","Antifolate resistance; ABC transporters; cAMP signaling pathway; Bile secretion","ABC-family proteins mediated transport; Platelet degranulation","Fluoropyrimidine activity; Drug induction of bile acid pathway; Ectoderm differentiation; Pregnane X receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; TYROBP causal network in microglia; Aspirin and miRNAs; Proximal tubule transport; FOXA2 pathway; Prostaglandin synthesis and regulation",506.3,501.1,440,425.6,426.8,604.3,0.9936157067343997,-0.009240115523085221,0.9631538331635073,0.016304342617455225,0.9786864127056965,0.009356441034268527,7193]
["O15446-1","DNA-directed RNA polymerase I subunit RPA34 [OS=Homo sapiens]",17,3,3,3,510,55,8.51,13.7,"RNA metabolism OR transcription;other metabolic processes;signal transduction","cytosol;mitochondrion;nucleus;other cell component","other molecular function","POLR1G","ENSG00000117877","RNA polymerase","B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","",60.4,50.1,53.2,66.1,46,54.9,0.9802395209580838,-0.02879378088726124,0.8750961548386507,0.05794422443882986,0.9180533652527196,0.03713207308942618,6967]
["O15498","Synaptobrevin homolog YKT6 [OS=Homo sapiens]",38,8,44,8,198,22.4,6.92,123.61,"cell organization and biogenesis;transport","plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","YKT6","ENSG00000106636","SNARE interactions in vesicular transport","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; COPI-mediated anterograde transport; RAC3 GTPase cycle; Intra-Golgi traffic; COPII-mediated vesicle transport","",7259.2,7203.8,7382.1,5781,6097,5020.4,1.292731856270416,0.3704230564729091,0.007021069139521877,2.153596750257593,0.08653793312102091,1.0627934817378824,593]
["O15504","nucleoporin-like protein 2 [OS=Homo sapiens]",7,2,4,2,423,44.8,9.19,8.16,"transport","other membranes;cytosol;nucleus","other molecular function","NUP42","ENSG00000136243","Nucleocytoplasmic transport","HCMV Early Events; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus","",185.9,177.2,161.2,204.4,190.6,228.6,0.8407633098139832,-0.25022838218142984,0.0669503682786374,1.1742470296909546,0.2552635585542831,0.5930111806850443,1917]
["O15511-1","Actin-related protein 2/3 complex subunit 5 [OS=Homo sapiens]",58,9,39,9,151,16.3,5.67,142.68,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity","Arpc5; ARPC5","ENSDLEG00000020693; ENSG00000162704; ENSGGOG00000007894; ENSPCTG00005002795; ENSPPAG00000038421; ENSPPYG00000000425; ENSPTRG00000001767; ENSRNOG00000028062; ENSSBOG00000027275; ENSSSCG00000015560; ENSSSCG00070012419; ENSSTOG00000001001","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection","Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; EPHB-mediated forward signaling; Neutrophil degranulation; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling","Pathogenic Escherichia coli infection; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton",3846.4,4046.6,4065.3,4410.4,4453.8,3513.1,0.966147705880927,-0.04968432792568024,0.679935988030806,0.1675319716372356,0.7801651705678432,0.10781344208861308,6370]
["O15527-1","N-glycosylase/DNA lyase [OS=Homo sapiens]",3,1,1,1,345,38.8,8.6,3.08,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","OGG1","ENSG00000114026","Base excision repair","Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Displacement of DNA glycosylase by APEX1; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; Defective OGG1 Substrate Binding; Defective OGG1 Substrate Processing","Base excision repair; DNA repair pathways, full network",105.4,99.9,117.5,121,102,130.6,0.9128959276018099,-0.1314776961136513,0.35748443676633085,0.4467428606422837,0.5572304858872067,0.2539651314971601,4689]
["O15530-1","3-phosphoinositide-dependent protein kinase 1 [OS=Homo sapiens]",25,10,18,10,556,63.1,7.36,46.45,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function","PDPK1","ENSG00000140992","Platinum drug resistance; PPAR signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Apoptosis; Axon guidance; Focal adhesion; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; Neurotrophin signaling pathway; Insulin signaling pathway; Thyroid hormone signaling pathway; Insulin resistance; Aldosterone-regulated sodium reabsorption; Toxoplasmosis; Proteoglycans in cancer; Chemical carcinogenesis; Endometrial cancer; Prostate cancer; Non-small cell lung cancer; Choline metabolism in cancer; Lipid and atherosclerosis","Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of TP53 Degradation; PIP3 activates AKT signaling; GPVI-mediated activation cascade; CD28 dependent PI3K/Akt signaling; G beta:gamma signalling through PI3Kgamma; RHO GTPases activate PKNs; Activation of AKT2; Integrin signaling; RSK activation; VEGFR2 mediated vascular permeability; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ","MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac hypertrophic response; Focal adhesion; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; PPAR signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; EGF/EGFR signaling pathway; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Modulators of TCR signaling and T cell activation; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway",2118.6,2155.2,2065.7,1819.7,1788.2,2346.4,1.0646927430596376,0.09043714686404708,0.521363616329567,0.2828592796092638,0.6631825046559007,0.1783669393812195,5746]
["O15533-1","Tapasin [OS=Homo sapiens]",11,5,40,5,448,47.6,7.15,107.11,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;ER/Golgi","signal transduction activity or receptor binding;transporter activity;other molecular function","TAPBP","ENSG00000112493; ENSG00000206208; ENSG00000206281; ENSG00000231925; ENSG00000236490; ENSPPAG00000024524; ENSPTRG00000018043","Antigen processing and presentation; Human cytomegalovirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection","ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC","",5025.6,4962.3,5109.3,4419.3,4543.7,7375.9,0.9240034518847658,-0.11402985362727273,0.6904959296591942,0.16083887716031245,0.7888144341792825,0.10302515102442777,6398]
["O15534-1","period circadian protein homolog 1 [OS=Homo sapiens]",2,2,2,2,1290,136.1,6.09,0,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PER1","ENSG00000179094","Circadian rhythm; Circadian entrainment","Circadian Clock","Melatonin metabolism and effects; Exercise-induced circadian regulation",149.4,178.5,203.6,132.4,132.6,290.1,0.9574851378130066,-0.06267800134311563,0.892830210490291,0.049231123035469324,0.9311780834009041,0.03096725431152072,7008]
["O15541","RING finger protein 113A [OS=Homo sapiens]",29,7,14,7,343,38.8,5.69,43.22,"protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus","other molecular function","RNF113A","ENSG00000125352","","","",1356.5,1308.8,1237.6,1317.8,1347.3,1185,1.0137139295083246,0.019650580637087602,0.7862769241169935,0.1044244699470064,0.856850758665738,0.06709481440368499,6707]
["O15550","Lysine-specific demethylase 6A [OS=Homo sapiens]",3,4,5,4,1401,154.1,7.44,12.76,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","KDM6A","ENSG00000147050","Transcriptional misregulation in cancer","Activation of anterior HOX genes in hindbrain development during early embryogenesis; HDMs demethylate histones","Mesodermal commitment pathway; Mesodermal commitment pathway; Pathways affected in adenoid cystic carcinoma",549.8,622.4,624.2,676.6,656.1,724.5,0.8732257437293409,-0.1955734315728842,0.05224158575438292,1.281983648847726,0.22620482836420897,0.6454981292533893,1688]
["O15553","Pyrin [OS=Homo sapiens]",2,2,5,1,781,86.4,8.03,11.75,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","MEFV","ENSG00000103313","NOD-like receptor signaling pathway; Yersinia infection","The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection","Nucleotide-binding oligomerization domain (NOD) pathway",234.5,224.7,244.7,254.3,282.6,239.4,0.9067370861780237,-0.14124380152345162,0.15805979946620213,0.8011785733950043,0.3893694217386152,0.40963815782787316,2967]
["O43143","Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 [OS=Homo sapiens]",41,32,171,32,795,90.9,7.46,501.7,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","DHX15","ENSG00000109606","Spliceosome","mRNA Splicing - Major Pathway","mRNA processing",19586.8,19847.5,19527.1,18872.9,18753.7,13842.8,1.145562217550622,0.19605581614075893,0.2069410540980488,0.6841533430724891,0.4427787366518263,0.3538132432054836,3416]
["O43148-1","mRNA cap guanine-N7 methyltransferase [OS=Homo sapiens]",41,18,47,18,476,54.8,6.61,140.64,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RNMT","ENSG00000101654","mRNA surveillance pathway","RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE","mRNA processing",5571.8,5482.8,5545.2,6097.7,6281.2,4832.5,0.9644654124591838,-0.05219859343863639,0.6780715007517419,0.16872450857440818,0.7788817537316488,0.10852846992665953,6363]
["O43149","Zinc finger ZZ-type and EF-hand domain-containing protein 1 [OS=Homo sapiens]",14,33,57,21,2961,330.9,5.95,161.32,"","","other molecular function","ZZEF1","ENSG00000074755","","","",4856.3,4889,4961.2,4537.7,4605.1,6038.2,0.9687438245174891,-0.04581288637843148,0.7631625880383871,0.11738292788301183,0.8398005654881919,0.07582383726140535,6642]
["O43149-3","Isoform 3 of Zinc finger ZZ-type and EF-hand domain-containing protein 1 [OS=Homo sapiens]",13,13,25,1,1085,119.9,5.67,74.37,"","","","ZZEF1","","","","",285.5,340.5,323.2,287.9,288.2,382.2,0.9905040175310447,-0.013765268121555515,0.9357149580163855,0.02885642798599888,0.9616339465891115,0.016990214064183235,7112]
["O43150-1","Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 [OS=Homo sapiens]",4,3,4,3,1006,111.6,6.68,13.77,"other biological processes","plasma membrane;other membranes;ER/Golgi","enzyme regulator activity;other molecular function","ASAP2","ENSG00000151693","Endocytosis; Fc gamma R-mediated phagocytosis","","Vitamin D receptor pathway",106.2,116.9,101.8,96.9,128.8,152.6,0.858842188739096,-0.2195350327198926,0.3477509820688001,0.45873163486155655,0.5501540969568962,0.259515648533709,4620]
["O43156","TELO2-interacting protein 1 homolog [OS=Homo sapiens]",7,7,9,7,1089,122,5.97,19.69,"other biological processes","nucleus;other cell component","","TTI1","ENSG00000101407","mTOR signaling pathway","","Fragile X syndrome; Malignant pleural mesothelioma",969.9,963.5,966.6,1082.4,997.3,1155.1,0.8965005564486213,-0.15762361632754687,0.07079725439044227,1.1499835844882191,0.26400874098966454,0.5783816939607221,1960]
["O43159","ribosomal rna-processing protein 8 [OS=Homo sapiens]",19,8,22,8,456,50.7,9.42,54.26,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","RRP8","ENSG00000132275","","SIRT1 negatively regulates rRNA expression","",1863.3,1821,1778.8,2255.8,2264.5,1651.7,0.8851425793907972,-0.17601823063849525,0.3117819840210133,0.5061489836510681,0.5298336482700736,0.27586046432118694,4301]
["O43164","E3 ubiquitin-protein ligase Praja-2 [OS=Homo sapiens]",3,1,2,1,708,78.2,4.39,6.64,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component","other molecular function","PJA2","ENSG00000198961","","Antigen processing: Ubiquitination & Proteasome degradation","",47.5,52.4,49,84.8,77.9,81.1,0.610746513535685,-0.7113543720381122,2.1250345194824622E-4,3.672634010790617,0.016349344529365598,1.7864996541954916,95]
["O43166-1","Signal-induced proliferation-associated 1-like protein 1 [OS=Homo sapiens]",1,2,2,2,1804,199.9,8.19,0,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;enzyme regulator activity","SIPA1L1","ENSG00000197555","Rap1 signaling pathway","Neurexins and neuroligins","",75.4,87.1,83.3,92.2,93.8,278.1,0.5296272355095885,-0.9169507817975302,0.30427433174271445,0.516734682714738,0.5235266221062853,0.28106122890417773,4248]
["O43169","Cytochrome b5 type B [OS=Homo sapiens]",55,5,29,5,146,16.3,4.97,98.99,"","other membranes","other molecular function","","","","","",2518.6,2595.6,2637,2621.4,2054.7,2395.4,1.0961182210280704,0.13240340750733662,0.24951087800424504,0.6029105155546843,0.4795358946444983,0.3191788790822938,3803]
["O43172-1","U4/U6 small nuclear ribonucleoprotein Prp4 [OS=Homo sapiens]",43,19,56,1,522,58.4,7.42,166.66,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity","PRPF4","ENSG00000136875; ENSPTRG00000021274","Spliceosome","mRNA Splicing - Major Pathway","mRNA processing; mRNA Processing",152.2,144.3,160,171.4,201.6,210.2,0.782750342935528,-0.3533758594553529,0.028574128244865535,1.5440270104241822,0.16734639690843123,0.7763836338866144,1248]
["O43172-2","Isoform 2 of U4/U6 small nuclear ribonucleoprotein Prp4 [OS=Homo sapiens]",43,19,57,1,521,58.3,7.42,168.72,"","","","PRPF4","","","","",6821.7,6753.2,6782.9,7079.9,7108.6,7296.6,0.9475310796784748,-0.07775482942671157,0.006054117997866956,2.217949118674608,0.0803077104290555,1.09524275564242,551]
["O43175","D-3-phosphoglycerate dehydrogenase [OS=Homo sapiens]",43,18,195,18,533,56.6,6.71,658.6,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytosol","other molecular function","PHGDH","ENSG00000092621","Glycine, serine and threonine metabolism; Cysteine and methionine metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids","Serine biosynthesis","Trans-sulfuration and one-carbon metabolism; Clear cell renal cell carcinoma pathways; Neuroinflammation and glutamatergic signaling",13977.7,14178.5,14758.2,15590.3,16148.3,18313.5,0.8573945948321849,-0.22196877270959586,0.05098290324057791,1.2925754371001403,0.22366989182796154,0.6503924722869361,1666]
["O43181","NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [OS=Homo sapiens]",23,4,8,4,175,20.1,10.3,15.99,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity","NDUFS4","ENSG00000164258","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",1090.3,1112.8,1098.2,1026.4,1052,514.3,{"$f":"AVERAGE(S322:U322)/AVERAGE(V322:X322)","v":1.2733058201874496},{"$f":"LOG(Y322,2)","v":0.34857896462785765},{"$f":"TTEST(V322:X322,S322:U322,2,2)","v":0.24899290712114205},0.6038130241573678,{"$f":"AA322*7309/AE322","v":0.47879220156496377},0.3198529318764986,3801]
["O43182","Rho GTPase-activating protein 6 [OS=Homo sapiens]",7,6,7,6,974,105.9,7.36,16.39,"cell adhesion;cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","ARHGAP6","ENSG00000047648","","RHOA GTPase cycle; RAC3 GTPase cycle","",341.9,389.4,371.5,395,386,383.3,0.9471785622262303,-0.07829166649641368,0.22484603834767392,{"$f":"-LOG10(AA323)","v":0.648114760036896},0.45599325590542417,{"$f":"-LOG10(AC323)","v":0.3410415804599485},3604]
["O43189-2","Isoform 1 of PHD finger protein 1 [OS=Homo sapiens]",18,5,10,5,457,49.6,7.93,27.84,"","","","PHF1","","","","",615.9,595.5,608.5,557.8,567.8,885,0.9051526907390829,-0.14376691308829523,0.586454421217377,0.2317657352670813,0.7109629067304376,0.14815305724846098,6029]
["O43237","Cytoplasmic dynein 1 light intermediate chain 2 [OS=Homo sapiens]",18,7,14,7,492,54.1,6.38,47.14,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","DYNC1LI2","ENSG00000135720","Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection","Separation of Sister Chromatids; COPI-mediated anterograde transport; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Intraflagellar transport proteins binding to dynein",1288.8,1279,1302.5,1491.6,1411.1,1674.7,0.8455236597194915,-0.24208296972294505,0.039526396149744424,1.4031127809929393,0.19520164152600133,0.7095165345039237,1480]
["O43242","26S proteasome non-ATPase regulatory subunit 3 [OS=Homo sapiens]",57,29,211,29,534,60.9,8.44,648.47,"protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","enzyme regulator activity","PSMD3","ENSG00000108344","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Interleukin-1 signaling; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease",19807.3,19602,20195,20029,19359.3,19592,1.010579803764986,0.015183253385101436,0.47205189307617973,0.3260102563704902,0.6274281299315871,0.20243601416839632,5499]
["O43251-1","RNA binding protein fox-1 homolog 2 [OS=Homo sapiens]",2,1,1,1,390,41.3,7.27,2.16,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RBFOX2","ENSG00000100320; ENSG00000277564","","FGFR2 alternative splicing","Mammalian disorder of sexual development",51.2,48.6,55.2,70.1,58.5,752,0.1760163524869407,-2.5062186287752937,0.35094796273659057,0.454757274336894,0.5523425193027004,0.2577915235194572,4644]
["O43252","bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [OS=Homo sapiens]",52,24,106,22,624,70.8,6.86,321.71,"other metabolic processes;developmental processes","cytosol","kinase activity;other molecular function","PAPSS1","ENSG00000138801","Purine metabolism; Selenocompound metabolism; Sulfur metabolism; Metabolic pathways","Signaling by BRAF and RAF1 fusions; Transport and synthesis of PAPS; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se","Sulfation biotransformation reaction",11492,11403.2,11272,11694.8,11725.5,12200.6,0.9591896891993184,-0.06011194428885577,0.051000568727397715,1.2924249808865076,0.22361317146283735,0.65050261883054,1667]
["O43264","Centromere/kinetochore protein zw10 homolog [OS=Homo sapiens]",36,19,56,19,779,88.8,6.27,186.12,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","nucleic acid binding activity","ZW10","ENSG00000086827","","COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",3018.4,3082.6,3095.7,2982.9,3055.2,1988.2,1.1458206147290784,0.1963811989831783,0.3214329874745866,0.4929095552545867,0.5362596908130001,0.27062484654878916,4381]
["O43278","Kunitz-type protease inhibitor 1 [OS=Homo sapiens]",17,9,13,9,529,58.4,6.29,35.9,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes","enzyme regulator activity","SPINT1","ENSG00000166145","Transcriptional misregulation in cancer; Prostate cancer","MET Receptor Activation; Signaling by MST1","",1457.4,1508.3,1567.5,1451.6,1433.4,3188.7,0.7463654773861073,-0.42204583800597784,0.42814403361323666,0.3684101036961584,0.5977659487448227,0.22346882782704655,5235]
["O43283","Mitogen-activated protein kinase kinase kinase 13 [OS=Homo sapiens]",2,1,1,1,966,108.2,6.49,0,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;other cell component","kinase activity;other molecular function","MAP3K13","ENSG00000073803","MAPK signaling pathway","","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Insulin signaling",242.6,274.1,269.7,203.3,270.6,49.8,1.501623066641207,0.5865227168912297,0.2557235757433083,0.5922292315229758,0.4848465927646797,0.31439565202597863,3855]
["O43290","U4/U6.U5 tri-snRNP-associated protein 1 [OS=Homo sapiens]",56,39,111,39,800,90.2,6.13,371.13,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","","SART1","ENSG00000175467","Spliceosome","mRNA Splicing - Major Pathway","",11042.6,10800.1,10651.1,11840.3,12343.4,13451.8,0.8633816476465042,-0.21192966821120107,0.024865216949633367,1.604407747185121,0.1558660983575217,0.8072483357241433,1166]
["O43291","Kunitz-type protease inhibitor 2 [OS=Homo sapiens]",13,3,3,3,252,28.2,8.29,4.49,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","enzyme regulator activity","SPINT2","ENSG00000167642","","MET Receptor Activation; Signaling by MST1","",433,412.7,385.4,385.9,378.6,1264.5,0.6067520946278954,-0.7208209110345445,0.4174110846835755,0.3794360220818012,0.592399537466457,0.22738528923901927,5150]
["O43292-1","Glycosylphosphatidylinositol anchor attachment 1 protein [OS=Homo sapiens]",10,6,10,6,621,67.6,8.06,27.83,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi","cytoskeletal activity","GPAA1","ENSG00000197858","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways","Attachment of GPI anchor to uPAR","",1341.2,1487.1,1539,1107.1,1215.3,1366.1,1.1840314490985497,0.24370740094655566,0.07716466608826654,1.112581518779373,0.2756581351119942,0.5596291862715415,2046]
["O43298","Zinc finger and BTB domain-containing protein 43 [OS=Homo sapiens]",2,1,1,1,467,52.6,5.76,2.49,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB43","ENSG00000169155","","","",46.4,66.6,62.5,37.7,57.2,0.6,1.837696335078534,0.8778983922688121,0.20655126630384274,0.684972138150065,0.4425925550908199,0.3539958956734892,3411]
["O43299","AP-5 complex subunit zeta-1 [OS=Homo sapiens]",3,2,2,2,807,88.5,7.01,4.08,"DNA metabolism;stress response;transport","other membranes;nucleus;other cell component","","AP5Z1","ENSG00000242802","","","",108.7,115.1,98.4,143.6,110.1,1476.2,0.18625354066709063,-2.4246602435176614,0.3558587648399862,0.4487223329851157,0.5555257821904013,0.2552957804617484,4682]
["O43301","Heat shock 70 kDa protein 12A [OS=Homo sapiens]",2,1,4,1,675,74.9,6.77,0,"","nucleus;other cell component","other molecular function","HSPA12A","ENSG00000165868","","Regulation of HSF1-mediated heat shock response","",146.1,353.8,546.6,72.2,126.1,3.4,5.188398611799702,2.37528932253011,0.08044058295755308,1.0945247907066844,0.28131111044820833,0.5508131149337654,2090]
["O43303","centriolar coiled-coil protein of 110 kDa [OS=Homo sapiens]",12,9,9,8,1012,113.4,8.65,21.8,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;other cell component","","CCP110","ENSG00000103540","","Ub-specific processing proteases; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; RHOV GTPase cycle","Genotoxicity pathway; Joubert syndrome",571.5,597.2,594.6,722.8,782.8,808.7,0.7619150499070995,-0.3922979421947198,2.3464165169817894E-3,2.629594892914991,0.051656500971746684,1.286875014735054,332]
["O43310","CBP80/20-dependent translation initiation factor [OS=Homo sapiens]",15,6,7,1,598,67.5,6.54,17.4,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity","CTIF","ENSG00000134030; ENSG00000282825","","","",392.3,402.5,413.6,489.9,442.7,1097.1,0.5953589200374441,-0.7481684163125794,0.2638499092538285,0.578643050854181,0.4910819930573549,0.30884599024062626,3927]
["O43310-2","Isoform 2 of CBP80/20-dependent translation initiation factor [OS=Homo sapiens]",15,6,7,1,600,67.7,6.54,15.96,"","","","CTIF","","","","",25.4,23.8,26.4,38,23.5,210.6,0.27783902976846747,-1.847678817028606,0.3370414989680549,0.4723166223831456,0.5447669871644213,0.26378921850851356,4522]
["O43314-1","inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 [OS=Homo sapiens]",15,16,30,13,1243,140.3,8.22,88.09,"other metabolic processes;other biological processes","cytosol","kinase activity;other molecular function","PPIP5K2","ENSG00000145725","Phosphatidylinositol signaling system","Synthesis of pyrophosphates in the cytosol","",2906,2848.9,2881.1,2710.5,2746.6,2651.8,1.0650026514077124,0.0908570221581526,0.005477564799039827,2.2614124760768926,0.07669640060571283,1.1152250171951819,522]
["O43318","mitogen-activated protein kinase kinase kinase 7 [OS=Homo sapiens]",3,2,2,2,606,67.2,7.11,3.79,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle","signal transduction activity or receptor binding;kinase activity;other molecular function","MAP3K7","ENSG00000135341","MAPK signaling pathway; NF-kappa B signaling pathway; Autophagy; AMPK signaling pathway; Wnt signaling pathway; Osteoclast differentiation; Adherens junction; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; IL-17 signaling pathway; T cell receptor signaling pathway; TNF signaling pathway; Alcoholic liver disease; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Leishmaniasis; Toxoplasmosis; Hepatitis B; Measles; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Ca2+ pathway; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; TNFR1-induced NFkappaB signaling pathway; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway","Regulation of toll-like receptor signaling pathway; IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; Fas ligand pathway and stress induction of heat shock proteins; Wnt signaling pathway; IL-6 signaling pathway; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Angiopoietin-like protein 8 regulatory pathway; Wnt signaling pathway and pluripotency; p38 MAPK signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; miRNAs involvement in the immune response in sepsis; Signal transduction through IL1R; Hepatitis B infection; IL-18 signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - interferon induction; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway",97.8,113,128.3,141.2,128.3,97.7,0.9234749455337692,-0.1148552743883769,0.5809931516661611,0.23582898673380912,0.7072749742718141,0.15041170842106888,6004]
["O43324-1","Eukaryotic translation elongation factor 1 epsilon-1 [OS=Homo sapiens]",53,8,37,8,174,19.8,8.54,111.53,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","EEF1E1","ENSANAG00000036153; ENSG00000124802; ENSPTRG00000017709","","Selenoamino acid metabolism; Cytosolic tRNA aminoacylation","",4427.9,4099.5,4772.8,5300,5283.6,2630.4,1.0065233842893901,0.009380690397792626,0.9762764922056693,0.010427167954460042,0.9858531198578664,0.006187784842667589,7238]
["O43353-1","Receptor-interacting serine/threonine-protein kinase 2 [OS=Homo sapiens]",10,4,5,4,540,61.2,7.09,10.76,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","RIPK2","ENSG00000104312","NOD-like receptor signaling pathway; Neurotrophin signaling pathway; Shigellosis; Salmonella infection; Tuberculosis","Downstream TCR signaling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; p75NTR recruits signalling complexes; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; activated TAK1 mediates p38 MAPK activation; Ovarian tumor domain proteases","Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Fas ligand pathway and stress induction of heat shock proteins; T-cell receptor (TCR) signaling pathway",234,236.2,233.8,260.4,227.8,276.2,0.9209837781266353,-0.11875234945279683,0.2311181831303582,0.6361658852325737,0.46141567891280744,0.3359076522301318,3661]
["O43379-4","Isoform 4 of WD repeat-containing protein 62 [OS=Homo sapiens]",7,10,16,10,1523,166.4,5.88,35.16,"","","","WDR62","","","","",1224.9,1209.2,1203.3,1240.3,1151.1,1239.4,1.0018177812052442,2.6201232456553275E-3,0.9455657789906755,0.024308253747556616,0.9674048542333212,0.014391737744073691,7144]
["O43390-1","heterogeneous nuclear ribonucleoprotein r [OS=Homo sapiens]",58,32,239,23,633,70.9,8.13,774.29,"RNA metabolism OR transcription;other metabolic processes;other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity","Hnrnpr; HNRNPR; LOC111154612","ENSAMEG00000009537; ENSCAFG00000013308; ENSCANG00000026442; ENSCATG00000035305; ENSFCAG00000019123; ENSG00000125944; ENSG00000282958; ENSGGOG00000013250; ENSLCNG00005013650; ENSMFAG00000039737; ENSMMUG00000010970; ENSMPUG00000015898; ENSNLEG00000008411; ENSRROG00000036942; ENSSSUG00005005658; ENSUAMG00000027050; ENSUMAG00000013292","","mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA","mRNA Processing; mRNA processing",26180.4,25769.7,25661.8,30181.9,28766.6,24215.1,0.9332436306268608,-0.09967433769643921,0.36366232080511507,0.4393016940349914,0.5609978688823525,0.25103878853776473,4738]
["O43395","U4/U6 small nuclear ribonucleoprotein Prp3 [OS=Homo sapiens]",42,24,72,24,683,77.5,9.5,192.25,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","other molecular function","PRPF3","ENSG00000117360","Spliceosome","mRNA Splicing - Major Pathway","mRNA processing",8232.7,7961.7,7994.5,9392.2,9415.7,8312.7,0.8919013591144739,-0.16504393248336047,0.05910767541548557,1.2283561202328912,0.24000999978432447,0.6197706634522242,1800]
["O43396","Thioredoxin-like protein 1 [OS=Homo sapiens]",59,13,79,13,289,32.2,4.96,327.32,"","cytosol;nucleus;other cell component","other molecular function","TXNL1","ENSG00000091164","","RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle","",9170.1,9553.4,9450.1,8421.9,8617.9,6289.4,1.2076539272671158,0.27220708632964,0.09902798751403566,1.0042420467647304,0.31171212779504165,0.5062463002833123,2322]
["O43399","Tumor protein D54 [OS=Homo sapiens]",60,11,30,11,206,22.2,5.36,92.73,"other metabolic processes;other biological processes","other cell component","other molecular function","TPD52L2","ENSG00000101150","","","",2311.2,2419.9,2513.4,2426.5,2858.8,2903.4,0.8846947622943812,-0.17674831300572247,0.12554429641440037,0.9012030128755435,0.35116848928161204,0.45448446071889625,2613]
["O43402","ER membrane protein complex subunit 8 [OS=Homo sapiens]",29,5,10,5,210,23.8,6.4,41.53,"cell organization and biogenesis","other membranes;cytosol;ER/Golgi;other cell component","","EMC8","ENSG00000131148","","","",1125.1,1207.6,1206.2,1071.4,1102,659.6,1.2491704906459582,0.32097039385826254,0.18049199544196257,0.7435420536612031,0.4135473337571487,0.3834747748344113,3190]
["O43414-1","ERI1 exoribonuclease 3 [OS=Homo sapiens]",3,1,3,1,337,37.2,8.07,8.56,"RNA metabolism OR transcription;other metabolic processes","","nucleic acid binding activity;other molecular function","ERI3","ENSG00000117419; ENSMFAG00000044436; ENSMLEG00000012810; ENSMMUG00000011651; ENSMNEG00000035539; ENSNLEG00000014004; ENSPANG00000013867; ENSPPAG00000042776; ENSPTRG00000000655; ENSRBIG00000044795; ENSRROG00000036414","","","",561.9,617.8,617.6,629.2,593.6,494.2,1.0467676179382641,0.06594119999678803,0.5797091368094605,0.23678985464965216,0.7063000635006412,0.15101075470313416,5999]
["O43422-1","52 kDa repressor of the inhibitor of the protein kinase [OS=Homo sapiens]",16,7,11,7,761,87.6,5.86,27.98,"other metabolic processes;signal transduction;other biological processes","","nucleic acid binding activity;kinase activity;other molecular function","THAP12","ENSG00000137492; ENSPTRG00000004091","","","",435.2,460.3,458.7,363.3,392,274.4,1.3151403321355737,0.3952167506005583,0.040805426703138296,1.3892820763584857,0.19817067360348026,0.702960614404375,1505]
["O43426","Synaptojanin-1 [OS=Homo sapiens]",7,9,12,9,1573,173,7.42,33.23,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity;other molecular function","SYNJ1","ENSG00000159082","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; Synthesis of IP3 and IP4 in the cytosol; Synthesis of IP2, IP, and Ins in the cytosol","VEGFA-VEGFR2 signaling pathway; EGF/EGFR signaling pathway",1045.6,1014.7,1024.4,1013.9,1081.3,1042.3,0.9831713147410359,-0.024485271004050263,0.46017870281661954,0.3370734844575703,0.6185079328588952,0.20865472582507866,5438]
["O43427","Acidic fibroblast growth factor intracellular-binding protein [OS=Homo sapiens]",23,9,17,9,364,41.9,6.48,41.38,"signal transduction","other membranes;mitochondrion;nucleus;other cell component","other molecular function","FIBP","ENSG00000172500","","","Modulators of TCR signaling and T cell activation",2049.1,2145,2150.7,2162.2,2092.2,1377.9,1.1265024945404187,0.17185050829780316,0.4005766956347525,0.3973143202736687,0.5818392425267103,0.23519699082690826,5032]
["O43432","Eukaryotic translation initiation factor 4 gamma 3 [OS=Homo sapiens]",15,23,56,17,1585,176.5,5.38,136.67,"protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus","nucleic acid binding activity","EIF4G3","ENSG00000075151","Viral myocarditis","ISG15 antiviral mechanism","Translation factors; Translation inhibitors in chronically activated PDGFRA cells",2266.5,2249.5,2295.8,2511.6,2561.4,2319.5,0.9214474129184985,-0.11802626140959128,0.061219831437775186,1.2131078705202079,0.2443777979129977,0.6119382529379314,1831]
["O43447","peptidyl-prolyl cis-trans isomerase H [OS=Homo sapiens]",47,8,66,7,177,19.2,8.07,156.88,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","PPIH","ENSG00000171960","Spliceosome","mRNA Splicing - Major Pathway","",5567,5804.7,5710,6010.3,6148.1,6364,0.9222185030017708,-0.11681948322437509,0.017934558764943858,1.7463093035883672,0.13612013500828107,0.8660776288289287,963]
["O43463","Histone-lysine N-methyltransferase SUV39H1 [OS=Homo sapiens]",8,3,4,3,412,47.9,8.03,9.35,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SUV39H1","ENSG00000101945","Lysine degradation; Metabolic pathways","PKMTs methylate histone lysines; SIRT1 negatively regulates rRNA expression","Histone modifications; Retinoblastoma gene in cancer; Interactions between LOXL4 and oxidative stress pathway; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome",205.3,220.1,204.4,263.5,291.9,215.6,0.8168612191958494,-0.2918371026669871,0.1083517513072028,0.9651640647141905,0.3263052947277896,0.48637587916215225,2427]
["O43464","Serine protease HTRA2, mitochondrial [OS=Homo sapiens]",30,9,36,9,458,48.8,10.07,113.17,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","HTRA2","ENSG00000115317","Apoptosis; Apoptosis; Parkinson disease; Pathways of neurodegeneration","","Parkinson's disease pathway; Nanomaterial induced apoptosis; Ciliary landscape; Complement system in neuronal development and plasticity",1971.4,2089.9,1999.6,1957.7,2058.9,1810.7,1.040087175879052,0.05670445426786379,0.38780914910680697,0.4113819493580602,0.5735526246098042,0.24142672854014788,4942]
["O43488","aflatoxin B1 aldehyde reductase member 2 [OS=Homo sapiens]",39,11,37,11,359,39.6,7.17,96.56,"other metabolic processes","cytosol;ER/Golgi","other molecular function","AKR7A2","ENSG00000053371","Metabolism of xenobiotics by cytochrome P450","Aflatoxin activation and detoxification","Aflatoxin B1 metabolism; Metapathway biotransformation Phase I and II",5378.8,5064.1,4905.9,4891.3,5124.2,4580.6,1.0515685696864232,0.0725429270275424,0.29822419667276273,0.5254571226028684,0.519475846873504,0.2844346402404157,4196]
["O43491-1","band 4.1-like protein 2 [OS=Homo sapiens]",48,43,149,40,1005,112.5,5.44,466.01,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","EPB41L2","ENSG00000079819","","Neurexins and neuroligins","Splicing factor NOVA regulated synaptic proteins",16126.5,16473,16390.1,15141.3,15325.6,14363.1,1.092786080749498,0.1280110126777175,0.011411895253590884,1.9426422232571845,0.11047621511059044,0.9567312130023996,755]
["O43493-1","Trans-Golgi network integral membrane protein 2 [OS=Homo sapiens]",37,16,34,2,480,51.1,5.73,98.24,"","","","","","","","",3670.1,3767.5,3542.8,5425.7,5494.7,3340.7,0.7699546318306443,-0.3771546547437692,0.19822980205525165,0.7028310527005169,0.43340162226199047,0.3631094674091125,3343]
["O43493-4","Isoform 4 of Trans-Golgi network integral membrane protein 2 [OS=Homo sapiens]",44,15,33,1,379,39.5,5.59,87.4,"","","","TGOLN2","","","","",422.7,386.2,372.6,741,712.3,783,0.5283280418548495,-0.9204941096208206,1.5789488007656705E-4,3.8016319522624147,0.014987710110125046,1.8242647155509237,77]
["O43502","DNA repair protein RAD51 homolog 3 [OS=Homo sapiens]",2,1,1,1,376,42.2,6.74,2.89,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","RAD51C","ENSG00000108384","Homologous recombination; Fanconi anemia pathway","Resolution of D-loop Structures through Holliday Junction Intermediates; Factors involved in megakaryocyte development and platelet production; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Meiotic recombination","DNA repair pathways, full network",20.7,198.4,21.8,32.7,29.1,33.7,2.5225130890052356,1.3348617553153597,0.45799575427902567,0.3391385479824572,0.6173904404325707,0.20944009934295096,5422]
["O43504","Ragulator complex protein LAMTOR5 [OS=Homo sapiens]",37,2,2,2,91,9.6,4.87,3.67,"cell organization and biogenesis;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","LAMTOR5","ENSG00000134248","mTOR signaling pathway","mTORC1-mediated signalling; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK","",62.3,55.2,54.9,67.9,78,54.8,0.8589935226706529,-0.21928084227351868,0.2568321893631524,0.590350546075517,0.4850611038902534,0.31420354921045546,3870]
["O43513","Mediator of RNA polymerase II transcription subunit 7 [OS=Homo sapiens]",6,1,2,1,233,27.2,5.78,6.96,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","MED7","ENSG00000155868","","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Generic Transcription Pathway","",49.7,46.7,48,58,63,109.3,0.6270082501085541,-0.6734436689056745,0.15485657333797156,0.8100703550226062,0.3873534204405319,0.4118926047369112,2922]
["O43521","Bcl-2-like protein 11 [OS=Homo sapiens]",15,2,2,2,198,22.2,8.21,4.69,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;other cell component","cytoskeletal activity;other molecular function","BCL2L11","ENSG00000153094","EGFR tyrosine kinase inhibitor resistance; FoxO signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Apoptosis; Non-alcoholic fatty liver disease; Epstein-Barr virus infection; Pathways in cancer; MicroRNAs in cancer; Colorectal cancer","NRAGE signals death through JNK; Signaling by BRAF and RAF1 fusions; Activation of BIM and translocation to mitochondria ; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; RUNX3 regulates BCL2L11 (BIM) transcription; FLT3 Signaling; FOXO-mediated transcription of cell death genes","Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Photodynamic therapy-induced unfolded protein response; BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Nonalcoholic fatty liver disease; EGFR tyrosine kinase inhibitor resistance; Host-pathogen interaction of human coronaviruses - apoptosis; Unfolded protein response; Galanin receptor pathway; ErbB signaling pathway; DNA damage response (only ATM dependent)",82,64.5,67.2,70.5,91,130.5,0.7318493150684932,-0.45038146110756855,0.2296400391744407,0.6389523877178395,0.4608564103036758,0.33643436729276766,3642]
["O43524","Forkhead box protein O3 [OS=Homo sapiens]",11,7,16,7,673,71.2,5.16,48.59,"RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","FOXO3","ENSG00000118689","EGFR tyrosine kinase inhibitor resistance; Chemokine signaling pathway; FoxO signaling pathway; Mitophagy; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Neurotrophin signaling pathway; Prolactin signaling pathway; Alcoholic liver disease; Shigellosis; Chemical carcinogenesis; Endometrial cancer; Non-small cell lung cancer","AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of localization of FOXO transcription factors; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; MAPK6/MAPK4 signaling; Signaling by NODAL; Interleukin-4 and Interleukin-13 signaling; FOXO-mediated transcription of cell cycle genes; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; RUNX3 regulates BCL2L11 (BIM) transcription; FLT3 Signaling; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation","IL-5 signaling pathway; Energy metabolism; Glioblastoma signaling pathways; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Kit receptor signaling pathway; Copper homeostasis; NAD metabolism, sirtuins and aging; Imatinib and chronic myeloid leukemia; Pathways affected in adenoid cystic carcinoma; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Non-small cell lung cancer; Overview of leukocyte-intrinsic Hippo pathway functions; Gastrin signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; DNA damage response (only ATM dependent)",1671,1658.7,1576.6,2468.2,2578.4,2778.4,0.6270031948881788,-0.6734553006039261,5.2303549833493314E-4,3.2814688346359744,0.024663654563419523,1.6079425709222932,155]
["O43566","Regulator of G-protein signaling 14 [OS=Homo sapiens]",27,12,22,1,566,61.4,8.19,49.83,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","RGS14","ENSG00000169220","Rap1 signaling pathway","G alpha (i) signalling events","Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells",1457.6,1471.5,1503.9,1507.3,1661.7,2534.2,0.7772829288820312,-0.3634882635673878,0.2563384073153231,0.5911863183750449,0.48475483028918404,0.3144778547454157,3865]
["O43566-5","Isoform 3 of Regulator of G-protein signaling 14 [OS=Homo sapiens]",36,12,24,1,414,44.8,9.2,56.83,"","","","RGS14","","","","",156,131.8,148.6,145.3,142.3,573.5,0.5067936360469167,-0.9805296866304222,0.3794691303060304,0.4208235480505642,0.5693984548155977,0.24458371573836116,4871]
["O43567","E3 ubiquitin-protein ligase RNF13 [OS=Homo sapiens]",8,2,5,2,381,42.8,4.98,13.39,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RNF13","ENSG00000082996","","","",804.5,959.6,974.2,954.4,1071.8,408.9,1.1245123403556325,0.16929949328308125,0.657437320991636,0.18214564579642878,0.7618851084712015,0.1181105149057756,6307]
["O43572","A-kinase anchor protein 10, mitochondrial [OS=Homo sapiens]",9,4,5,4,662,73.8,6.39,16.72,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;other cell component","other molecular function","AKAP10","ENSG00000108599","","Factors involved in megakaryocyte development and platelet production","G protein signaling pathways",230.1,196.5,217,251.1,230,339.8,0.7840175417224996,-0.35104216111710657,0.1668689596289226,0.7776244417246468,0.3987071676782593,0.3993459568253525,3059]
["O43583","density-regulated protein [OS=Homo sapiens]",22,5,11,5,198,22.1,5.3,35.13,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","","nucleic acid binding activity","DENR","ENSG00000139726","","","",1044.8,922.6,917.2,1045.8,1092.6,855.3,0.963556802618833,-0.053558377571379254,0.686268302043393,0.16350606021695044,0.7854580362723393,0.10487701253640355,6386]
["O43592","Exportin-T [OS=Homo sapiens]",29,21,53,21,962,109.9,5.39,161.81,"transport","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","XPOT","ENSG00000184575","Nucleocytoplasmic transport","tRNA processing in the nucleus","",4354.9,4430,4450.1,4513.4,4113,6574.5,0.8706721312553863,-0.1997985490393706,0.43891656185438127,0.3576180313986747,0.6044923969462357,0.21860915714408727,5307]
["O43598-1","2'-deoxynucleoside 5'-phosphate N-hydrolase 1 [OS=Homo sapiens]",68,8,60,8,174,19.1,5.05,166.11,"other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","C6orf108; DNPH1","ENSG00000112667","","Purine catabolism","",5072.7,4759.7,5249.5,5684.6,5691.1,6981.2,0.8215929704906602,-0.28350425680677666,0.07411017459614937,1.1301221635777225,0.2700255563924505,0.5685951303781489,2006]
["O43615","Mitochondrial import inner membrane translocase subunit TIM44 [OS=Homo sapiens]",56,29,144,29,452,51.3,8.32,402.17,"cell organization and biogenesis;transport","other membranes;mitochondrion;nucleus","other molecular function","TIMM44","ENSG00000104980","","Mitochondrial protein import","",18112.4,17879.7,18442.8,17154.6,17212.4,17275.2,1.0540778665509993,0.07598144528403297,5.0801761357421715E-3,2.2941212299493894,0.07396615015167236,1.1309669852104356,502]
["O43617-1","Trafficking protein particle complex subunit 3 [OS=Homo sapiens]",47,9,26,9,180,20.3,4.96,60.57,"transport","other membranes;cytosol;ER/Golgi;other cell component","","TRAPPC3","ENSCANG00000028241; ENSCATG00000041647; ENSCSAG00000001096; ENSG00000054116; ENSGGOG00000004752; ENSMMUG00000022499; ENSMNEG00000014589; ENSPPAG00000041117; ENSPPYG00000001546; ENSRBIG00000043692; ENSRROG00000034420","","COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs","",4815.2,5109.5,5271.2,5092.8,5009.6,4117.2,1.0686587527075302,0.09580124092363562,0.3921741281428464,0.406521060274078,0.577088927440319,0.23875725838532835,4967]
["O43633","charged multivesicular body protein 2a [OS=Homo sapiens]",33,9,33,9,222,25.1,5.97,66.06,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle","other molecular function","CHMP2A","ENSG00000130724","Endocytosis; Necroptosis","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Lysosome Vesicle Biogenesis; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","",3245.8,3316.4,3398.8,3656.7,3612.8,3639.6,0.9130909057575786,-0.13116959529458824,2.3549117951184827E-3,2.628025355036451,0.05153308476203889,1.2879138599640425,334]
["O43639","Cytoplasmic protein NCK2 [OS=Homo sapiens]",22,8,11,7,380,42.9,6.95,32.89,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","NCK2","ENSG00000071051","ErbB signaling pathway; Axon guidance; T cell receptor signaling pathway; Pathogenic Escherichia coli infection","RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; Downstream signal transduction; VEGFA-VEGFR2 Pathway; Ephrin signaling; Activation of RAC1; Regulation of cortical dendrite branching","Pathogenic Escherichia coli infection; Brain-derived neurotrophic factor (BDNF) signaling pathway; EGF/EGFR signaling pathway; Genes controlling nephrogenesis; ErbB signaling pathway",998.9,940.5,898.5,1010.2,1007.6,874.6,0.9811575162494814,-0.027443327790780354,0.7508435691559594,0.12445053453895,0.8311245868485396,0.08033386992798745,6603]
["O43660-1","Pleiotropic regulator 1 [OS=Homo sapiens]",37,13,23,13,514,57.2,9.17,85.7,"RNA metabolism OR transcription;other metabolic processes;other biological processes","other membranes;nucleus;other cell component","","PLRG1","ENSG00000171566","Spliceosome","mRNA Splicing - Major Pathway","",2063.2,2039.5,2007.8,2478.4,2522.9,2725.3,0.7908394377863485,-0.33854327733554834,2.2673587478424617E-3,2.6444797591491795,0.05021856087266834,1.299135737143094,330]
["O43663-1","Protein regulator of cytokinesis 1 [OS=Homo sapiens]",25,12,17,12,620,71.6,6.68,47.23,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","PRC1","ENSG00000198901","","RHO GTPases activate CIT","",1098.3,1105.2,1158.7,1730.3,1321.3,1622.7,0.7192948676807221,-0.4753447846766013,0.02422183306431306,1.6157929933320225,0.15381179658302707,0.8130103550778414,1151]
["O43670-1","BUB3-interacting and GLEBS motif-containing protein ZNF207 [OS=Homo sapiens]",13,6,33,6,478,50.7,9.1,112.27,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","LOC111151255; Znf207; ZNF207","ENSAMEG00000005671; ENSANAG00000033773; ENSCANG00000036057; ENSCJAG00000014376; ENSECAG00000017464; ENSG00000010244; ENSGGOG00000024003; ENSMFAG00000001904; ENSMLEG00000018149; ENSMMUG00000016875; ENSMNEG00000041308; ENSNLEG00000005954; ENSOCUG00000008195; ENSPCOG00000020744; ENSPPAG00000032098; ENSPTRG00000008989; ENSRROG00000037743; ENSSBOG00000026038; ENSSTOG00000000712","","","",3554,3593.8,3482,3916.2,4030.8,4956,0.8238239169185461,-0.2795920843416563,0.08379358147013401,1.0767892467499325,0.2878041762054556,0.54090290848897,2128]
["O43674-1","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [OS=Homo sapiens]",25,6,26,6,189,21.7,9.63,70.78,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB5","ENSG00000136521; ENSGGOG00000005222; ENSPTRG00000015649","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",2946.5,3084.7,3143.4,3228.6,3310.1,1843.9,1.0944814258106077,0.13024747108504872,0.6110838310409069,0.2138992073333756,0.7286152889197371,0.13750171996781768,6130]
["O43676","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [OS=Homo sapiens]",11,1,5,1,98,11.4,9.2,14.66,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity","NDUFB3","ENSG00000119013","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease",506.9,507.1,519.6,759.8,804.6,422.1,0.7720110747545935,-0.3733065513073106,0.27953403903120394,0.5535653002522648,0.5053461022208928,0.2964110797019661,4043]
["O43678","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [OS=Homo sapiens]",29,2,3,2,99,10.9,9.57,10.45,"cell organization and biogenesis;other metabolic processes;transport;developmental processes","other membranes;mitochondrion","transporter activity","NDUFA2","ENSG00000131495","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",174.5,170.2,157.1,198.6,191.7,230.1,0.8088330109606705,-0.3060862156269183,0.03771258023520204,1.423513752835028,0.19049153347552988,0.7201243220700924,1447]
["O43681","ATPase ASNA1 [OS=Homo sapiens]",50,11,55,11,348,38.8,4.91,159.62,"cell organization and biogenesis;transport","ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","GET3","ENSG00000198356","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",5916.2,6067.3,6042,5886.9,5263,4360.5,1.1621557148751807,0.21680338546138117,0.1330154469996159,0.8760979217611065,0.35901399635162207,0.44488861989024026,2708]
["O43683","Mitotic checkpoint serine/threonine-protein kinase BUB1 [OS=Homo sapiens]",14,13,24,13,1085,122.3,6.47,63.69,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","BUB1","ENSG00000169679","Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Cell cycle; ATM signaling in development and disease ; Regulation of sister chromatid separation at the metaphase-anaphase transition",1694.4,1764.9,1764.9,1320.6,1271.7,1747.3,{"$f":"AVERAGE(S386:U386)/AVERAGE(V386:X386)","v":1.2038436722278552},{"$f":"LOG(Y386,2)","v":0.26764805991775237},{"$f":"TTEST(V386:X386,S386:U386,2,2)","v":0.12596334750482757},0.8997558064067464,{"$f":"AA386*7309/AE386","v":0.35193658521130916},0.45353558417500306,2616]
["O43684","Mitotic checkpoint protein BUB3 [OS=Homo sapiens]",40,11,57,11,328,37.1,6.84,184.97,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","BUB3","ENSG00000154473","Cell cycle; Human T-cell leukemia virus 1 infection","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A","Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition",4081.9,4137.3,4167.3,4480.1,4289,4940.3,0.9035041650254568,-0.1463968431635951,0.08643992754416881,{"$f":"-LOG10(AA387)","v":1.0632856058237437},0.29276618647837344,{"$f":"-LOG10(AC387)","v":0.5334790842866626},2158]
["O43707","Alpha-actinin-4 [OS=Homo sapiens]",72,59,636,38,911,104.8,5.44,2080.36,"transport;signal transduction;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function","ACTN4","ENSG00000130402; ENSG00000282844","Focal adhesion; Adherens junction; Tight junction; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Shigellosis; Amoebiasis; Viral carcinogenesis; Systemic lupus erythematosus","Platelet degranulation ; Nephrin family interactions","Arrhythmogenic right ventricular cardiomyopathy; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Striated muscle contraction pathway; Ebola virus pathway in host; Nephrotic syndrome",67663.2,67200.8,68008.1,64818.1,64268.4,78807.3,0.9758448784908449,-0.035276261462171554,0.7429945482889255,0.1290143728568175,0.8254365638309403,0.08331629737002988,6579]
["O43708","maleylacetoacetate isomerase [OS=Homo sapiens]",5,2,4,2,216,24.2,8.54,8.57,"other metabolic processes;other biological processes","cytosol;mitochondrion","other molecular function","GSTZ1","ENSG00000100577","Tyrosine metabolism; Metabolic pathways","Regulation of pyruvate dehydrogenase (PDH) complex; Glutathione conjugation; Tyrosine catabolism","Metapathway biotransformation Phase I and II",659.8,622.5,660.7,585.4,583,866.6,0.9547911547911547,-0.06674289356826493,0.7629475307897269,0.11750532819456522,0.8401963993584622,0.07561918395263506,6637]
["O43709-1","Probable 18S rRNA (guanine-N(7))-methyltransferase [OS=Homo sapiens]",16,3,9,3,281,31.9,8.73,35.36,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","BUD23","ENSG00000071462; ENSGGOG00000001453","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","7q11.23 copy number variation syndrome",698.2,703.2,734.8,1116.2,1101.8,1123.9,0.639217211765762,-0.6456218396333647,6.8523221356941138E-6,5.164162228534044,0.007154803212826897,2.145402306664328,7]
["O43719","HIV Tat-specific factor 1 [OS=Homo sapiens]",66,46,151,46,755,85.8,4.4,460.43,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","","HTATSF1","ENSG00000102241","","","",15221.4,15476.3,15253.6,14812.8,15296.4,16307.7,0.9899691707115297,-0.014544496921510103,0.7462844898936168,0.12709558427215792,0.8283361179396272,0.08179340168598756,6585]
["O43739","cytohesin-3 [OS=Homo sapiens]",18,6,17,2,400,46.3,5.47,57.64,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","CYTH3","ENSG00000008256","Phospholipase D signaling pathway; Endocytosis; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection","Intra-Golgi traffic","Insulin signaling",463.2,484.8,454.1,586.6,611.6,1137.7,0.6002397362900809,-0.7363892653696118,0.15865737818248954,0.7995397267187265,0.39031530701306494,0.4085844166384176,2971]
["O43741","5'-AMP-activated protein kinase subunit beta-2 [OS=Homo sapiens]",4,1,1,1,272,30.3,6.46,2.61,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","PRKAB2","ENSG00000131791","FoxO signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Apelin signaling pathway; Tight junction; Circadian rhythm; Thermogenesis; Insulin signaling pathway; Adipocytokine signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Insulin resistance; Non-alcoholic fatty liver disease; Alcoholic liver disease; Hypertrophic cardiomyopathy","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Carnitine metabolism; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; AMPK inhibits chREBP transcriptional activation activity; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Lipophagy","AMP-activated protein kinase (AMPK) signaling; Target of rapamycin (TOR) signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Angiopoietin-like protein 8 regulatory pathway; Lipid metabolism pathway; Caloric restriction and aging; Genotoxicity pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; Malignant pleural mesothelioma",68.3,60.6,65.1,65.9,60.9,49.3,1.1016467915956842,0.13966174324328162,0.3311838444303267,0.4799308568083221,0.5414052155985816,0.26647756479238094,4471]
["O43747-1","AP-1 complex subunit gamma-1 [OS=Homo sapiens]",28,21,71,21,822,91.3,6.8,217.4,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","AP1G1","ENSCANG00000031796; ENSCCAG00000037984; ENSCJAG00000015028; ENSG00000166747; ENSGGOG00000004800; ENSMFAG00000037769; ENSMLEG00000040277; ENSMMUG00000010878; ENSMNEG00000034875; ENSPANG00000016832; ENSPPAG00000031149; ENSPTRG00000008327; ENSRBIG00000018408; ENSRROG00000025423; ENSSBOG00000025975","Lysosome; Human immunodeficiency virus 1 infection","MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression","",7238.7,7691.7,7523.6,7224.4,6492.4,4606,1.2254677232737357,0.29333248658244343,0.156708281883815,0.8049080508741295,0.3883963486906761,0.41072486154195464,2949]
["O43752","Syntaxin-6 [OS=Homo sapiens]",49,6,22,6,255,29.2,4.93,71.86,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","STX6","ENSG00000135823","SNARE interactions in vesicular transport","Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network","",1396.4,1436.5,1516.6,1251.7,1374.4,1315.7,1.1034299051194885,0.14199498598507168,0.053210786745297146,1.274000319789518,0.22810418787177528,0.6418667412340616,1705]
["O43760","Synaptogyrin-2 [OS=Homo sapiens]",42,6,64,6,224,24.8,4.94,159.97,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","SYNGR2","ENSG00000108639","","","",5387.1,5401.6,5481.2,4717.2,4866.4,5040.2,1.1125630820990442,0.153887138911698,4.9601900952912755E-3,2.3045016792045514,0.07338872349490674,1.1343706662442254,494]
["O43765","Small glutamine-rich tetratricopeptide repeat-containing protein alpha [OS=Homo sapiens]",39,11,76,11,313,34,4.87,190.79,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","SGTA","ENSG00000104969","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",8246.4,8617.3,9011.2,8752.8,9262,6439.7,1.0580833793371363,0.08145331952800332,0.6251894441246527,0.20398836334177675,0.7388051167513479,0.13147010542294327,6185]
["O43766-1","Lipoyl synthase, mitochondrial [OS=Homo sapiens]",4,2,2,2,372,41.9,8.59,4.94,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","mitochondrion","other molecular function","LIAS","ENSG00000121897","Lipoic acid metabolism; Metabolic pathways; Biosynthesis of cofactors","Glyoxylate metabolism and glycine degradation","",232.3,238.8,207.3,257.9,268.6,164.8,0.9813395052799077,-0.027175755743980425,0.9063693630030479,0.042694782870598046,0.9410019423564314,0.0264094801287373,7040]
["O43768","alpha-endosulfine [OS=Homo sapiens]",17,2,3,2,121,13.4,7.24,9.83,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","ENSA","ENSG00000143420","","MASTL Facilitates Mitotic Progression","",306.8,386.8,323.4,254.7,241.2,118.2,1.6560820713238884,0.7277741710002955,0.0542711397499085,1.265431057692712,0.23102373933143924,0.6363433909696554,1717]
["O43772","mitochondrial carnitine/acylcarnitine carrier protein [OS=Homo sapiens]",49,14,46,14,301,32.9,9.41,134.56,"transport;developmental processes","other membranes;cytosol;mitochondrion","transporter activity","SLC25A20","ENSG00000178537","Thermogenesis","Carnitine metabolism","Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation; Thermogenesis",7492.6,7803.8,7713.1,7116.8,6572.5,5849.2,1.1776492565959515,0.2359099202240697,0.03780262797807553,1.4224780076573618,0.19028884841029892,0.7205866621374638,1452]
["O43776","Asparagine--tRNA ligase, cytoplasmic [OS=Homo sapiens]",44,27,177,26,548,62.9,6.25,523.97,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","NARS1","ENSG00000134440","Aminoacyl-tRNA biosynthesis","Cytosolic tRNA aminoacylation","Photodynamic therapy-induced unfolded protein response",21249.2,20587.8,20504.1,21624.7,21700,21522.9,0.9613478370826368,-0.056869570196493975,0.025718979274579695,1.58974627152597,0.15849917328659613,0.7999729986702409,1186]
["O43791","Speckle-type POZ protein [OS=Homo sapiens]",3,1,1,1,374,42.1,5.8,3.23,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","SPOP","ENSG00000121067","Hedgehog signaling pathway","Hedgehog 'on' state","mRNA processing; Hedgehog signaling pathway",47.9,44.3,43.7,101,83.8,49.2,0.5807692307692306,-0.7839630737033761,0.09921202017585976,1.003435707081725,0.3121569760935682,0.5056269549979875,2323]
["O43795","Unconventional myosin-Ib [OS=Homo sapiens]",7,7,9,7,1136,131.9,9.38,22.07,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","MYO1B","ENSG00000128641","Pathogenic Escherichia coli infection","","",590.7,615.9,630.5,595,555.3,855.9,0.9157112949855449,-0.1270352770725554,0.5848674382653493,0.23294255674460085,0.7105711612834836,0.14839242244421375,6016]
["O43808","peroxisomal membrane protein PMP34 [OS=Homo sapiens]",8,3,6,3,307,34.5,10.08,14.39,"other metabolic processes;transport","other membranes;cytosol;other cytoplasmic organelle","transporter activity;other molecular function","SLC25A17","ENSG00000100372","Peroxisome","Class I peroxisomal membrane protein import; Alpha-oxidation of phytanate","",794.3,805.2,780.4,790.2,800.9,428.8,1.1782266448834102,0.2366170841584172,0.38275029583045583,0.41708446496024376,0.5705735085100554,0.24368839632244907,4903]
["O43809","Cleavage and polyadenylation specificity factor subunit 5 [OS=Homo sapiens]",60,13,65,13,227,26.2,8.82,198.22,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","NUDT21","ENSG00000167005","mRNA surveillance pathway","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs","mRNA processing",8922.5,8704.8,9231.9,8855,9240.8,9662.8,0.9675992305087431,-0.04751847288418111,0.34296511338812896,0.4647500543991807,0.5477998281804708,0.26137810830017555,4576]
["O43813","LanC-like protein 1 [OS=Homo sapiens]",23,8,19,8,399,45.3,7.75,56.37,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","LANCL1","ENSG00000115365","Glutathione metabolism; Metabolic pathways","","",1673.4,1670.1,1641.9,1518.3,1540.6,1446.6,1.106514260348463,0.14602204418134443,0.006004267012948803,2.2215400026926293,0.08022886215291189,1.0956693671420872,547]
["O43815","striatin [OS=Homo sapiens]",31,19,52,19,780,86.1,5.27,148.03,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","STRN","ENSG00000115808","","Extra-nuclear estrogen signaling; PIP3 activates AKT signaling; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins","",5055.8,5092.1,5096.5,5585.3,5696.3,6241.7,0.8699502947504182,-0.20099512101292377,0.02016806885168798,1.6953356846929195,0.14283761166374753,0.8451574201001392,1032]
["O43818","U3 small nucleolar RNA-interacting protein 2 [OS=Homo sapiens]",34,14,42,14,475,51.8,7.85,119.52,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","RRP9","ENSG00000114767","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",5265.1,4971.1,4944.3,5294.4,4605.5,7108.3,0.8925400689079385,-0.16401115721096488,0.4641081025452517,0.3333808494651005,0.6213896540581141,0.20663598188708876,5459]
["O43819","Protein SCO2 homolog, mitochondrial [OS=Homo sapiens]",41,9,41,9,266,29.8,8.85,136.52,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","other membranes;cytoskeleton;mitochondrion","other molecular function","SCO2","ENSG00000284194","Central carbon metabolism in cancer","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","",2895.2,2842.9,2921.9,2897.6,2781.2,3879.4,0.9060283316942521,-0.14237193053668895,0.439397783664928,0.3571421380038548,0.6044717486931975,0.21862399202961905,5313]
["O43823","A-kinase anchor protein 8 [OS=Homo sapiens]",30,12,37,12,692,76.1,5.15,125.45,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","mitochondrion;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","AKAP8","ENSG00000105127","","","G protein signaling pathways",3213.8,3194.7,3146.9,3875.2,4080.6,2723.5,0.8947590197859411,-0.16042891281473567,0.42561872502294446,0.3709792735813145,0.595719506164822,0.2249581791842672,5222]
["O43824","Putative GTP-binding protein 6 [OS=Homo sapiens]",11,5,7,5,516,56.8,9.42,21.19,"","","","","","","","",730.6,600.5,610.4,715.5,642.9,1442.4,0.6931948014852899,-0.5286672596326645,0.33024487843179984,0.48116390887181626,0.541080434086085,0.26673817022945995,4461]
["O43826-1","Glucose-6-phosphate exchanger SLC37A4 [OS=Homo sapiens]",9,3,9,3,429,46.3,8.62,22.03,"other metabolic processes;transport;other biological processes","other membranes;ER/Golgi","transporter activity","SLC37A4","ENSG00000281500","Carbohydrate digestion and absorption","Gluconeogenesis; Glycogen storage disease type Ib (SLC37A4)","",893.5,837.9,913.1,777.8,803.8,690.5,1.1639012367413406,0.21896864303259017,0.038883247029135905,1.41023747553704,0.19346334413611593,0.7134013094433235,1469]
["O43829","Zinc finger and BTB domain-containing protein 14 [OS=Homo sapiens]",20,5,6,5,449,50.9,6.04,14.2,"developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB14","ENSG00000198081","","","",358.8,346.1,334.6,407,461.2,656,0.6819971132397323,-0.5521624622706662,0.100438460531616,0.9980999525476064,0.3143917379124545,0.5025288755657644,2335]
["O43837-1","isocitrate dehydrogenase [NAD] subunit beta, mitochondrial [OS=Homo sapiens]",46,15,78,14,385,42.2,8.46,228.86,"other metabolic processes","mitochondrion","other molecular function","IDH3B","ENSG00000101365","Citrate cycle (TCA cycle); Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids","Citric acid cycle (TCA cycle)","TCA cycle (aka Krebs or citric acid cycle)",11645.2,12207.7,12448.1,10834.9,9659,8646,1.2457489558989563,0.31701336485425347,0.02417570151417407,1.6166209149982402,0.15365234988443327,0.8134607934678789,1150]
["O43847-1","Nardilysin [OS=Homo sapiens]",26,26,63,26,1150,131.5,5,183.22,"","","","","","","","",7055.2,7390.2,7391.5,7337.2,6665.7,5638.7,1.111767880417074,0.15285560755121907,0.2219586436740208,0.6537279376995017,0.45531735240342913,0.34168579816654426,3563]
["O43852","Calumenin [OS=Homo sapiens]",71,22,218,6,315,37.1,4.64,726.76,"","non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","CALU","ENSG00000128595","","Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","NOTCH1 regulation of endothelial cell calcification; VEGFA-VEGFR2 signaling pathway",25589.9,26228.4,22458.1,26480.9,23816.2,18907.5,1.073287035832878,0.10203595661107208,0.536801245223797,0.27018648540017365,0.6749493035163826,0.17072884647258882,5813]
["O43852-4","Isoform 4 of Calumenin [OS=Homo sapiens]",59,17,159,1,323,38.1,4.58,498.58,"","","","CALU","","","","",345.6,415.8,381.4,353.2,365.9,218.7,1.2185967157176374,0.2852207572155518,0.25343279907772576,0.596137179757729,0.4830092121144974,0.31604458615875575,3835]
["O43861-1","Probable phospholipid-transporting ATPase IIB [OS=Homo sapiens]",9,8,12,8,1147,129.2,7.61,36.53,"cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ATP9B","ENSG00000166377","","Ion transport by P-type ATPases","",1434.8,1348.2,1354.3,1227,1412.9,1309.5,1.0475768471160176,0.06705607961594064,0.35964263200937074,0.4441288326534791,0.5588069722271451,0.2527381838375882,4704]
["O43865","S-adenosylhomocysteine hydrolase-like protein 1 [OS=Homo sapiens]",29,14,43,7,530,58.9,6.89,134.9,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","nucleic acid binding activity;other molecular function","AHCYL1","ENSG00000168710","Cysteine and methionine metabolism; Metabolic pathways","Role of phospholipids in phagocytosis; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Ion homeostasis; Regulation of insulin secretion; VEGFR2 mediated cell proliferation; PLC beta mediated events; DAG and IP3 signaling; CLEC7A (Dectin-1) induces NFAT activation","Trans-sulfuration and one-carbon metabolism; One-carbon metabolism and related pathways",3535.3,3560.3,3572.9,3186.4,2955.9,2999.9,1.166951062107589,0.22274406067243868,2.0625418908318694E-3,2.6855972220399185,0.048317688077211964,1.3158938541743885,312]
["O43896","Kinesin-like protein KIF1C [OS=Homo sapiens]",9,10,10,4,1103,122.9,6.9,26.12,"transport;other biological processes","cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","KIF1C","ENSG00000129250","","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",277.7,311.4,266,279.9,332.3,632,0.6872689278251084,-0.5410533598593731,0.30569514325841624,0.514711461086882,0.5249825662772003,0.27985511848990086,4256]
["O43903","Growth arrest-specific protein 2 [OS=Homo sapiens]",38,9,25,9,313,34.9,8.47,91.92,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton","cytoskeletal activity;other molecular function","GAS2","ENSG00000148935","","Caspase-mediated cleavage of cytoskeletal proteins","",2823.2,2852.1,2994.3,2971.8,3130.2,2280.9,1.034200574980019,0.048516012023082214,0.7375993708398589,0.13217946240032463,0.8214404695213362,0.08542390477327477,6563]
["O43913","Origin recognition complex subunit 5 [OS=Homo sapiens]",19,9,17,9,435,50.3,7.74,48.42,"DNA metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ORC5","ENSG00000164815","Cell cycle","CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication","Cell cycle; G1 to S cell cycle control; DNA replication",2035,2145.2,2144,1984.5,2112.6,1643.4,1.1016810382370874,0.1397065912763836,0.24995945574218523,0.6021304296296214,0.4798932655685925,0.3188553445600157,3807]
["O43920","NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [OS=Homo sapiens]",11,1,2,1,106,12.5,9.14,3.58,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity","NDUFS5","ENSG00000168653","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",52.8,53.3,61.5,60.2,62.7,76.1,0.842211055276382,-0.2477462817316595,0.1394338978485029,0.8556316318412067,0.3668547009988149,0.4355059113588305,2778]
["O43924","Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [OS=Homo sapiens]",25,3,5,3,150,17.4,5.67,16.56,"other biological processes","other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","PDE6D","ENSG00000156973","Purine metabolism; Metabolic pathways","ARL13B-mediated ciliary trafficking of INPP5E; RAS processing","Phosphodiesterases in neuronal function; Joubert syndrome; Ciliopathies",476.8,437.3,485,564.2,523.5,529.5,0.8651372743012613,-0.20899902659972983,0.020111274673787993,1.6965604024888563,0.14271194814632662,0.8455396653100556,1030]
["O43929","origin recognition complex subunit 4 [OS=Homo sapiens]",15,5,11,5,436,50.3,8,26.58,"DNA metabolism;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ORC4","ENSG00000115947","Cell cycle","CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication","Cell cycle; G1 to S cell cycle control; DNA replication",857.8,846.5,861.2,906,876.8,877.7,0.9642924262356699,-0.05245737799154189,0.040063496450832056,1.39725115132204,0.1966582240155349,0.7062878871902433,1489]
["O43933","Peroxisome biogenesis factor 1 [OS=Homo sapiens]",8,11,16,11,1283,142.8,6.33,44.12,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","PEX1","ENSG00000127980","Peroxisome","Peroxisomal protein import","",1364.6,1363.3,1367.1,1321.8,1363.9,1689.4,0.9359786062032865,-0.09545254058847025,0.4665744488568869,0.33107904827758794,0.6230938510314246,0.20544653453612005,5473]
["O43934","UNC93-like protein MFSD11 [OS=Homo sapiens]",4,3,3,3,449,49.2,5.68,7.53,"","other membranes","","MFSD11","ENSG00000092931","","","",428,436.8,436.4,381,320.4,537,1.0507105943152453,0.07136535089672129,0.7620720944480325,0.11800394107524684,0.8397384197679284,0.07585597648965024,6633]
["O60216","Double-strand-break repair protein rad21 homolog [OS=Homo sapiens]",52,26,97,26,631,71.6,4.65,350.07,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","RAD21","ENSG00000164754","Cell cycle","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin","Cell cycle; Prion disease pathway; Regulation of sister chromatid separation at the metaphase-anaphase transition; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome",7010.7,6955.6,7016.2,8137,8262,7143.3,0.8912680579212736,-0.16606869268898666,0.07376474727346517,1.1321511411907914,0.2691695146389201,0.5699741286003948,2003]
["O60231","Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [OS=Homo sapiens]",23,21,45,21,1041,119.2,6.8,125.94,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","DHX16","ENSG00000204560; ENSG00000206486; ENSG00000226171; ENSG00000231377; ENSG00000233049; ENSG00000233418; ENSG00000233561","Spliceosome","mRNA Splicing - Major Pathway","mRNA processing",5800,5820.4,5852.8,6783.3,6634.3,6338.5,0.8844458167350845,-0.17715433221129195,0.004445223955353381,2.3521063539009606,0.06972133452720572,1.156634308706988,466]
["O60232","Sjoegren syndrome/scleroderma autoantigen 1 [OS=Homo sapiens]",27,3,5,3,199,21.5,5.24,24.01,"cell cycle OR cell proliferation;other biological processes","","","ZNRD2","ENSG00000173465","","","",299.8,314.6,303.7,469.7,479.7,702.2,0.5558852022281425,-0.8471411171115606,0.032392075466103044,1.4895612244319762,0.17854726966949258,0.7482467866167575,1326]
["O60234","glia maturation factor gamma [OS=Homo sapiens]",45,6,29,5,142,16.8,5.26,95.43,"protein metabolism;other metabolic processes;signal transduction;other biological processes","non-structural extracellular;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function","GMFG","ENSG00000130755","","Neutrophil degranulation","",2386.6,2384.4,2377.6,2702.7,2764.4,2701.4,0.8751423149905123,-0.19241044887280512,8.457617108544522E-5,4.072751980032142,0.012363344689270382,1.907864022484188,50]
["O60237","Protein phosphatase 1 regulatory subunit 12b [OS=Homo sapiens]",13,11,12,10,982,110.3,5.67,29.37,"signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP1R12B","ENSG00000077157","Vascular smooth muscle contraction; Focal adhesion; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Proteoglycans in cancer","RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs","Focal adhesion",608.1,583.5,579,706.3,721.5,854.8,0.7756943835976517,-0.3664397390138192,0.023727948559334425,1.6247398078371624,0.15199612271706864,0.818167490371404,1141]
["O60244","Mediator of RNA polymerase II transcription subunit 14 [OS=Homo sapiens]",6,7,13,6,1454,160.5,8.73,34.12,"other biological processes","nucleus","other molecular function","MED14","ENSG00000180182","Thyroid hormone signaling pathway","Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","Vitamin D in inflammatory diseases",804.3,811.8,748.3,763.9,785.9,1622.8,0.7452562566979763,-0.4241915126692378,0.3956574396393458,0.4026806637190109,0.5787192768308943,0.2375320512776247,4997]
["O60256-1","Phosphoribosyl pyrophosphate synthase-associated protein 2 [OS=Homo sapiens]",34,10,27,9,369,40.9,7.44,112.72,"other metabolic processes;other biological processes","other cell component","enzyme regulator activity;other molecular function","PRPSAP2","ENSG00000141127","","","",2769.8,2738.9,2803.6,2837.7,2664.5,2649.7,1.0196763944601874,0.028111369665505613,0.4450468703376211,0.3515942486660803,0.6083500234332658,0.215846470882448,5347]
["O60264","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 [OS=Homo sapiens]",39,40,133,40,1052,121.8,8.09,366.57,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMARCA5","ENSG00000153147","","Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; NoRC negatively regulates rRNA expression","",14255.6,13689.6,13609.2,15770,16147.3,21682.8,0.7752672103223688,-0.36723444699865954,0.10493185450947858,0.9790926515812262,0.32076408390204053,0.49381426581302795,2391]
["O60266","Adenylate cyclase type 3 [OS=Homo sapiens]",4,4,8,4,1144,128.9,6.58,20.91,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","ADCY3","ENSG00000138031","Purine metabolism; Metabolic pathways; Endocrine resistance; Rap1 signaling pathway; Calcium signaling pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Phospholipase D signaling pathway; Oocyte meiosis; Longevity regulating pathway; Longevity regulating pathway; Adrenergic signaling in cardiomyocytes; Vascular smooth muscle contraction; Apelin signaling pathway; Gap junction; Platelet activation; Circadian entrainment; Thermogenesis; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; GABAergic synapse; Olfactory transduction; Inflammatory mediator regulation of TRP channels; Insulin secretion; GnRH signaling pathway; Ovarian steroidogenesis; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Melanogenesis; Thyroid hormone synthesis; Oxytocin signaling pathway; Regulation of lipolysis in adipocytes; Aldosterone synthesis and secretion; Relaxin signaling pathway; Cortisol synthesis and secretion; Parathyroid hormone synthesis, secretion and action; Cushing syndrome; Growth hormone synthesis, secretion and action; Vasopressin-regulated water reabsorption; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Bile secretion; Morphine addiction; Vibrio cholerae infection; Human cytomegalovirus infection; Human T-cell leukemia virus 1 infection; Pathways in cancer; Chemical carcinogenesis; Dilated cardiomyopathy","FCGR3A-mediated IL10 synthesis; Olfactory Signaling Pathway; G alpha (i) signalling events; G alpha (z) signalling events; Adenylate cyclase inhibitory pathway; ADORA2B mediated anti-inflammatory cytokines production; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Adenylate cyclase activating pathway; Hedgehog 'off' state","Thyroid stimulating hormone (TSH) signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; Phosphodiesterases in neuronal function; Thermogenesis; Envelope proteins and their potential roles in EDMD physiopathology; Neuroinflammation and glutamatergic signaling; Calcium regulation in cardiac cells",307.4,294,313.6,265.4,307.7,350.7,0.9904741285992639,-0.013808802790269687,0.9132671304098978,0.03940217285520019,0.9457451765607741,0.02422586499517761,7058]
["O60268-1","Uncharacterized protein KIAA0513 [OS=Homo sapiens]",9,3,3,3,411,46.6,5.06,9.16,"","other cell component","","KIAA0513","ENSG00000135709","","","",364.4,361.3,314.4,319.6,341.4,249,1.142967032967033,0.1927837919505686,0.2497556243473682,0.6024847229397262,0.47975397065832176,0.3189814221623449,3805]
["O60271","C-jun-amino-terminal kinase-interacting protein 4 [OS=Homo sapiens]",33,37,102,2,1321,146.1,5.15,305,"transport;other biological processes","other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","SPAG9","ENSG00000008294","","Myogenesis","",10486,10215.1,10166,10545.3,10468.9,9689.2,1.0053316570803235,0.007671522390804946,0.8604128343182836,0.06529312009764092,0.9083861629398143,0.04172948982510423,6923]
["O60271-2","Isoform 2 of C-Jun-amino-terminal kinase-interacting protein 4 [OS=Homo sapiens]",32,36,103,1,1311,145,5.19,309.2,"","","","SPAG9","","","","",389.5,386.1,381.3,387.6,387.5,124.8,1.2855872874763865,0.36242756811331317,0.38355760856383964,0.4161693978103922,0.5714273463092344,0.2430389797967861,4906]
["O60281-1","zinc finger protein 292 [OS=Homo sapiens]",2,5,5,5,2723,304.6,7.39,7.84,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF292","ENSG00000188994","","","",93.9,82.9,91,107.8,100.7,461,0.4,-1.3219280948873622,0.3233757425647511,0.4902925610078204,0.5371712050922195,0.2698872756100349,4400]
["O60285","NUAK family SNF1-like kinase 1 [OS=Homo sapiens]",2,1,1,1,661,74.3,8.82,2.03,"cell adhesion;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","NUAK1","ENSG00000074590","","Regulation of TP53 Activity through Phosphorylation","",61.4,53.1,56.3,82.8,80.8,156,0.5344180225281602,-0.9039594333074864,0.11673531861941362,0.9327977269803045,0.33979229143341066,0.4687864778092539,2511]
["O60287","nucleolar pre-ribosomal-associated protein 1 [OS=Homo sapiens]",8,14,26,14,2271,254.2,6.47,81.68,"RNA metabolism OR transcription;other metabolic processes","nucleus","","URB1","ENSG00000142207","","","",2774.6,2901.2,2795.7,3446.5,3317.7,10983.1,0.4773402151313158,-1.0669102086827025,0.28945237093204557,0.5384228887349831,0.5128745161557142,0.289988879736954,4125]
["O60291-1","E3 ubiquitin-protein ligase MGRN1 [OS=Homo sapiens]",6,2,2,2,552,60.7,5.15,7.27,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MGRN1","ENSG00000102858","Ubiquitin mediated proteolysis; Hedgehog signaling pathway","Antigen processing: Ubiquitination & Proteasome degradation","",119.9,139,138.3,130,115.8,163.8,0.9697265625,-0.04435009247162612,0.803513074762269,0.09500705200467308,0.8699269831784068,0.06051719810952035,6751]
["O60292","Signal-induced proliferation-associated 1-like protein 3 [OS=Homo sapiens]",1,1,1,1,1781,194.5,8.32,2.87,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","enzyme regulator activity","SIPA1L3","ENSG00000105738","Rap1 signaling pathway","","",24,31.6,25.7,21.3,21.1,16.5,1.3803056027164682,0.46498771824456664,0.055217953530575785,1.2579196930761067,0.23274972454151005,0.6331108243323254,1734]
["O60293","Zinc finger C3H1 domain-containing protein [OS=Homo sapiens]",8,11,13,11,1989,226.2,8.13,35.99,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","other molecular function","ZFC3H1","ENSG00000133858","","","",622,591.4,569.3,830.6,884.6,868.4,0.6900061929091191,-0.5353187845339751,2.7042096537175942E-4,3.5679596411612367,0.01830098922131657,1.7375254347642133,108]
["O60294","tRNA wybutosine-synthesizing protein 4 [OS=Homo sapiens]",5,3,3,3,686,75.6,6.73,3.98,"RNA metabolism OR transcription;other metabolic processes","other cell component","other molecular function","LCMT2","ENSG00000168806","","Synthesis of wybutosine at G37 of tRNA(Phe)","",355,348.5,350.6,354.7,347.9,191.8,1.1785554561717353,0.23701964527590055,0.3739333684892989,0.42720577821524686,0.5674997903422521,0.24603429458104203,4816]
["O60306","Intron-binding protein aquarius [OS=Homo sapiens]",14,20,39,19,1485,171.2,6.37,107.07,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","AQR","ENSG00000021776","Spliceosome","mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER","",3683.9,3653,3746.5,4478,4610.9,4476.3,0.8170465603161029,-0.29150980057618087,9.3956289994688588E-5,4.02707414032616,0.012485936792203252,1.9035788679364307,55]
["O60307","Microtubule-associated serine/threonine-protein kinase 3 [OS=Homo sapiens]",3,4,6,2,1309,143,8.06,12.05,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction","","kinase activity;other molecular function","MAST3","ENSG00000099308","","","",136.1,145.2,148.5,205.7,198.1,274.2,0.6339233038348082,-0.6576197905959229,0.0278022684760528,1.5559197671596683,0.16494056841840088,0.782672513104102,1232]
["O60308","Centrosomal protein of 104 kDa [OS=Homo sapiens]",2,2,3,2,925,104.4,7.62,7.45,"","cytoskeleton;other cell component","other molecular function","CEP104","ENSG00000116198","","","Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies",285.6,318.6,318.4,293,235.7,337.8,1.0647432198499713,0.0905055430181241,0.5848813299765707,0.23293224154924994,0.7104699419642273,0.14845429115693276,6017]
["O60313-2","Isoform 2 of Dynamin-like 120 kDa protein, mitochondrial [OS=Homo sapiens]",41,39,101,39,997,115.8,7.87,303.65,"","","","OPA1","","","","",12707.5,12778,12827.4,12934.5,12496.6,10329.4,{"$f":"AVERAGE(S450:U450)/AVERAGE(V450:X450)","v":1.0713748409558033},{"$f":"LOG(Y450,2)","v":0.0994633228292612},{"$f":"TTEST(V450:X450,S450:U450,2,2)","v":0.35075794299085106},0.45499248549407806,{"$f":"AA450*7309/AE450","v":0.5522813023093774},0.25783965973000406,4642]
["O60318","Germinal-center associated nuclear protein [OS=Homo sapiens]",12,13,21,13,1980,218.3,6.39,81.22,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","MCM3AP","ENSG00000160294","","","",1237.6,1235.7,1230.1,1281.1,1266.5,1720,0.8677945449432936,-0.20457457765180578,0.27493507252616844,{"$f":"-LOG10(AA451)","v":0.5607698551619682},0.5018732380354058,{"$f":"-LOG10(AC451)","v":0.2994059620852763},4004]
["O60331","Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [OS=Homo sapiens]",9,6,10,5,668,73.2,5.29,22.5,"cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","PIP5K1C","ENSG00000186111","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Phospholipase D signaling pathway; Endocytosis; Focal adhesion; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Yersinia infection; Choline metabolism in cancer","Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion","B cell receptor signaling pathway; Focal adhesion; Regulation of actin cytoskeleton",964.2,988.8,923.4,882.3,877.3,1325.8,0.9322616192389969,-0.10119322175246699,0.6662622828575453,0.17635477146918707,0.7688208123469843,0.11417486862110726,6334]
["O60333","Kinesin-like protein KIF1B [OS=Homo sapiens]",15,21,28,9,1816,204.3,5.6,85.55,"cell-cell signaling;transport;other biological processes","other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","KIF1B","ENSG00000054523","","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","Intracellular trafficking proteins involved in CMT neuropathy",2288.2,2269.9,2233.1,2461.7,2460.7,3108.3,0.8456547997061278,-0.24185922632353363,0.12873309442019815,0.8903097912738465,0.35359270466637666,0.4514967039412623,2661]
["O60333-3","Isoform 3 of Kinesin-like protein KIF1B [OS=Homo sapiens]",13,13,18,1,1153,130.3,8.43,47.74,"","","","KIF1B","","","","",33.5,38.5,51.6,47,43.7,28.9,1.0334448160535117,0.0474613537062695,0.8717944605030039,0.059585894873991185,0.9157725943973061,0.03821235740158836,6958]
["O60337","E3 ubiquitin-protein ligase MARCH6 [OS=Homo sapiens]",2,2,2,2,910,102.5,6.28,5.33,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","other molecular function","MARCHF6","ENSG00000145495","Protein processing in endoplasmic reticulum","ER Quality Control Compartment (ERQC)","",216.9,207.9,217,282.2,288.9,535.9,0.5797651309846431,-0.7864595273871073,0.13695633356372353,0.8634178789399705,0.36374049491906074,0.43920834661947117,2752]
["O60341","Lysine-specific histone demethylase 1A [OS=Homo sapiens]",20,13,20,13,852,92.8,6.52,66.77,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KDM1A","ENSG00000004487","Thermogenesis","Estrogen-dependent gene expression; Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; Factors involved in megakaryocyte development and platelet production; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3","Androgen receptor signaling pathway; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; Thermogenesis; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects",1841.5,1840.2,1896.4,2261.8,2179,2059,0.8581956367888244,-0.2206215286870196,0.007606819727568119,2.118796875877241,0.0912943274036049,1.0395562066261432,609]
["O60343-1","TBC1 domain family member 4 [OS=Homo sapiens]",1,1,1,1,1298,146.5,7.01,0,"transport;other biological processes","cytosol;other cell component","enzyme regulator activity","TBC1D4","ENSG00000136111","Thyroid hormone signaling pathway; Insulin resistance; Diabetic cardiomyopathy","Translocation of SLC2A4 (GLUT4) to the plasma membrane","Ciliary landscape; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling",35.7,34.4,35.3,23.3,23.9,18.5,1.6042617960426178,0.6819095913148848,1.6444887345243575E-3,2.7839690972805453,0.04370752058414011,1.3594438292268352,275]
["O60344-1","Endothelin-converting enzyme 2 [OS=Homo sapiens]",5,4,10,4,883,99.7,5.1,26.93,"protein metabolism;other metabolic processes;developmental processes","plasma membrane;other membranes;ER/Golgi","other molecular function","EEF1AKMT4-ECE2","ENSG00000284917","","","",1196.4,1134.9,1241.8,1393.1,1286.6,2842.5,0.6470428452428381,-0.6280668485539697,0.265882446136205,0.5753103343413715,0.4929819378004876,0.3071689924008229,3942]
["O60353-1","Frizzled-6 [OS=Homo sapiens]",6,3,3,3,706,79.2,7.96,6.58,"cell-cell signaling;cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","FZD6","ENSG00000164930","mTOR signaling pathway; Wnt signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Proteoglycans in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer","Class B/2 (Secretin family receptors); Ca2+ pathway; PCP/CE pathway; Regulation of FZD by ubiquitination; Signaling by RNF43 mutants","Alzheimer's disease and miRNA effects; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Osteoblast differentiation and related diseases; Malignant pleural mesothelioma; Alzheimer's disease",99.3,91.7,88.1,115.1,126.5,246.4,0.5719262295081968,-0.8060990233841812,0.17367385776561328,0.7602655487525706,0.40581273222789876,0.391674331256408,3128]
["O60361","putative nucleoside diphosphate kinase [OS=Homo sapiens]",66,8,139,1,137,15.5,8.57,432.69,"other metabolic processes;other biological processes","","kinase activity;other molecular function","NME2P1","","","Interconversion of nucleotide di- and triphosphates","",696.8,897.7,918.4,692.4,652.8,165.6,1.6632909716706383,0.7340405719121554,0.1428810073399455,0.8450254965809658,0.3713788345119707,0.43018285104477927,2812]
["O60381-1","HMG box-containing protein 1 [OS=Homo sapiens]",5,2,2,2,514,57.6,6.19,7.78,"cell-cell signaling;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HBP1","ENSG00000105856; ENSG00000283847; ENSPPAG00000042116; ENSPTRG00000019575","","","",207.1,187.7,201.3,154.4,152.8,222,1.1264172335600904,0.17174131169214915,0.396719290485209,0.4015166814326001,0.5792291838107057,0.2371495648208316,5006]
["O60427","Fatty acid desaturase 1 [OS=Homo sapiens]",2,1,1,1,444,51.9,8.87,2.12,"cell-cell signaling;other metabolic processes;stress response;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","FADS1","ENSG00000149485","Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism","PPARA activates gene expression; alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Linoleic acid metabolism affected by coronavirus infection",269.8,263.5,257,367,389,419.4,0.6723668538369917,-0.5726794901581382,1.1991440121512508E-3,2.9211286568287176,0.037778205106954704,1.4227586798356442,232]
["O60447","Ecotropic viral integration site 5 protein homolog [OS=Homo sapiens]",3,2,2,2,810,92.9,6.1,6.74,"cell cycle OR cell proliferation;transport;other biological processes","cytosol;cytoskeleton;nucleus","enzyme regulator activity;other molecular function","EVI5","ENSG00000067208","","","",79.8,79.7,84.9,96.1,89.2,93.6,0.8762997490139837,-0.19050364920958232,0.01223590842767585,1.9123637818919919,0.11524775089933348,0.9383675412662074,776]
["O60449","Lymphocyte antigen 75 [OS=Homo sapiens]",7,11,15,11,1722,198.2,6.67,42.58,"stress response;transport;other biological processes","plasma membrane;other membranes","other molecular function","LY75","ENSG00000054219","","","",1648.7,1513.4,1553.2,1687.8,1741.2,1922.4,0.8811339088836566,-0.18256680786222304,0.060062907961562155,1.2213936451459049,0.24213998581966784,0.6159334873574406,1813]
["O60476","mannosyl-oligosaccharide 1,2-alpha-mannosidase IB [OS=Homo sapiens]",7,4,10,4,641,73,7.61,26.26,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","MAN1A2","ENSG00000198162","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum","Intra-Golgi traffic; Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2","",770.8,797,785.4,758.6,743.5,1118.5,0.897962298710219,-0.15527322075124,0.5081124438248692,0.29404016895843554,0.6533768212378552,0.18483627632989472,5684]
["O60486","Plexin-C1 [OS=Homo sapiens]",24,30,84,29,1568,175.6,7.61,247.2,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","PLXNC1","ENSG00000136040","Axon guidance","Other semaphorin interactions","",8593.9,8728.9,8887.5,7173.7,7596.6,6837.2,1.2130186277912762,0.27860170545903995,2.8658217165564315E-3,2.542750830660272,0.056156275941852435,1.2506017005849865,373]
["O60488-1","Long-chain-fatty-acid--CoA ligase 4 [OS=Homo sapiens]",42,23,70,20,711,79.1,8.38,174.26,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ACSL4","ENSG00000068366","Fatty acid biosynthesis; Fatty acid degradation; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; Peroxisome; Ferroptosis; Thermogenesis; Adipocytokine signaling pathway","Synthesis of very long-chain fatty acyl-CoAs; Intracellular metabolism of fatty acids regulates insulin secretion","Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters",8293.3,8514.6,8841.4,8245.1,8046.9,7127.4,1.0952159320904893,0.13121533872521127,0.12163173065414527,0.9149531137938736,0.34672633360029165,0.4600131727566804,2564]
["O60493-1","sorting nexin-3 [OS=Homo sapiens]",15,2,3,2,162,18.8,8.66,9.39,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","LOC111158258; Snx3; SNX3; Snx3_1","ENSAMEG00000008145; ENSANAG00000028701; ENSBIXG00000016466; ENSBIXG00005007963; ENSBMUG00000010256; ENSBTAG00000018801; ENSCANG00000036155; ENSCATG00000029122; ENSCCAG00000022069; ENSCGRG00015001325; ENSCHIG00000003391; ENSCJAG00000005955; ENSCSAG00000015156; ENSDLEG00000017815; ENSFCAG00000024997; ENSG00000112335; ENSLCNG00005012116; ENSMFAG00000039300; ENSMMNG00015010894; ENSMMUG00000020366; ENSMNEG00000027766; ENSMPUG00000009812; ENSMUSG00000019804; ENSNVIG00000004406; ENSOARG00000010805; ENSPANG00000017995; ENSPCOG00000020531; ENSPCTG00005013214; ENSPPAG00000032382; ENSPPYG00000016894; ENSPTRG00000018473; ENSPTRG00000046352; ENSRFEG00010011106; ENSRROG00000037899; ENSSBOG00000028606; ENSSSCG00000004385; ENSSSCG00070023370; ENSSSUG00005019212; ENSSTOG00000007274; ENSTSYG00000035289; ENSTTRG00000008868; ENSUAMG00000027552","Endocytosis","Ub-specific processing proteases; WNT ligand biogenesis and trafficking; Ub-specific processing proteases; WNT ligand biogenesis and trafficking; WNT ligand biogenesis and trafficking; Ub-specific processing proteases; WNT ligand biogenesis and trafficking","",318.5,316.7,336.7,470.7,471.2,662.4,0.6058093872717074,-0.7230641614133503,0.030307027530396106,1.5184566565208852,0.17238448577405846,0.7635018223042257,1285]
["O60496","Docking protein 2 [OS=Homo sapiens]",43,11,20,11,412,45.4,6.02,62.11,"signal transduction","cytosol","signal transduction activity or receptor binding","DOK2","ENSG00000147443","","RET signaling; Tie2 Signaling","RAC1/PAK1/p38/MMP2 pathway; IL-4 signaling pathway; EGF/EGFR signaling pathway",1622.4,1646.7,1648.2,1788.8,1798.2,2269.3,0.8396598534911122,-0.2521230849306182,0.12010155098269291,0.9204513841135324,0.34451422140208104,0.4627928458928723,2548]
["O60499","Syntaxin-10 [OS=Homo sapiens]",19,2,3,2,249,28.1,4.89,9.32,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","STX10","ENSG00000104915","Salmonella infection","Retrograde transport at the Trans-Golgi-Network","",23.6,29,25.7,21.3,24.2,23.3,1.1380813953488371,0.18660374258894263,0.15161765892939932,0.8192502134205738,0.38292103286626805,0.4168907783196195,2894]
["O60502","protein O-GlcNAcase [OS=Homo sapiens]",33,27,59,27,916,102.8,4.91,160.99,"protein metabolism;other metabolic processes","cytosol;nucleus","other molecular function","OGA","ENSG00000198408","Insulin resistance","","",6474.7,6913.5,6711.6,8554.2,8713.5,6651.8,0.8403102071531596,-0.25100608639366756,0.13202523621657428,0.8793430468088828,0.35766213917974105,0.4465270302607952,2698]
["O60506","Heterogeneous nuclear ribonucleoprotein Q [OS=Homo sapiens]",58,32,270,2,623,69.6,8.59,831.37,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity","SYNCRIP","ENSG00000135316","","","",15912.3,15263.8,15330,18221.6,17923,15128.9,0.9070201956176192,-0.14079342087776137,0.18941488717891625,0.7225858903508501,0.42363323451367774,0.373009976327255,3268]
["O60506-3","Isoform 3 of Heterogeneous nuclear ribonucleoprotein Q [OS=Homo sapiens]",56,29,255,1,562,62.6,7.56,769.42,"","","","SYNCRIP","","","","",428.6,403.4,403,565.7,581.9,1295,0.505608777532138,-0.983906585501764,0.1696272612165256,0.7705043499302084,0.40123160266394353,0.39660486747107015,3090]
["O60508","pre-mRNA-processing factor 17 [OS=Homo sapiens]",21,10,17,10,579,65.5,7.06,44.75,"RNA metabolism OR transcription;other metabolic processes","nucleus","","CDC40","ENSG00000168438","Spliceosome","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway","mRNA processing",1362.7,1468.7,1493.8,1884.7,2035.2,1401.4,0.8128089000808073,-0.2990118954936396,0.16443377259140046,0.7840089791089307,0.3957347526738709,0.402595809143223,3037]
["O60512","beta-1,4-galactosyltransferase 3 [OS=Homo sapiens]",22,6,13,6,393,43.9,9.25,41.19,"protein metabolism;other metabolic processes","other membranes;cytosol;ER/Golgi","other molecular function","B4GALT3","ENSG00000158850","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Other types of O-glycan biosynthesis; Mannose type O-glycan biosynthesis; Glycosaminoglycan biosynthesis; Glycosphingolipid biosynthesis; Metabolic pathways","N-Glycan antennae elongation; Keratan sulfate biosynthesis","",421.9,548.1,603.3,592,681.3,877.6,0.7314612487795805,-0.45114665933343684,0.1264576042767556,0.8980550500986406,0.35250901207429697,0.45282977556873316,2622]
["O60518","ran-binding protein 6 [OS=Homo sapiens]",7,6,30,3,1105,124.6,5.01,74.1,"transport","nucleus;other cell component","other molecular function","RANBP6","ENSG00000137040","","","",197.8,171.9,195.2,196.5,195.8,258,0.8686759956942952,-0.20310992310487214,0.269034700476456,0.5701917004678041,0.4959330708152375,0.30457693023745375,3965]
["O60524","nuclear export mediator factor NEMF [OS=Homo sapiens]",16,16,29,16,1076,122.9,6.35,83.71,"protein metabolism;other metabolic processes;transport","nucleus;other cell component","translation activity;nucleic acid binding activity","NEMF","ENSG00000165525","","","",3484.3,3597.3,3568,3779.2,3725.1,3271.4,0.9882977439980699,-0.01698234753364767,0.810955529683398,0.0910029605146612,0.8747452724994031,0.05811839595333876,6776]
["O60547-1","GDP-mannose 4,6 dehydratase [OS=Homo sapiens]",32,11,32,11,372,41.9,7.31,83.54,"other metabolic processes;signal transduction","cytosol;other cell component","other molecular function","GMDS","ENSG00000112699; ENSPPAG00000026874; ENSPPYG00000016168; ENSPTRG00000017663","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars","GDP-fucose biosynthesis","",3876.1,3934.5,4028.6,3581.9,3324.7,3696.9,1.1165369925024757,0.1590310505475492,0.025552291393390172,1.5925701485670578,0.15813860947865266,0.8009620842965995,1181]
["O60551","Glycylpeptide N-tetradecanoyltransferase 2 [OS=Homo sapiens]",20,8,34,4,498,56.9,7.58,109.02,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","NMT2","ENSG00000152465","","Membrane binding and targetting of GAG proteins; Inactivation, recovery and regulation of the phototransduction cascade","",446.2,421.7,402.2,414.8,367.4,2429.6,0.3954480353695746,-1.338439967926673,0.39493681504367645,0.40347238050734324,0.5788235775324305,0.23745378684173332,4987]
["O60563","Cyclin-T1 [OS=Homo sapiens]",18,11,17,11,726,80.6,8.78,48.91,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","CCNT1","ENSG00000129315","Transcriptional misregulation in cancer","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interactions of Tat with host cellular proteins","Initiation of transcription and translation elongation at the HIV-1 LTR; Male infertility",1784.3,1762.1,1691.8,1881.5,1950,1825.1,0.9260333062263549,-0.11086401170047583,0.03776849421302076,1.4228703296551874,0.1903792580710129,0.7203803700061895,1450]
["O60566","Mitotic checkpoint serine/threonine-protein kinase BUB1 beta [OS=Homo sapiens]",20,18,29,18,1050,119.5,5.27,70.87,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","BUB1B","ENSG00000156970","Cell cycle; Human T-cell leukemia virus 1 infection","Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A","Regulation of sister chromatid separation at the metaphase-anaphase transition",2911.5,2963.5,2970.7,3456.6,3177.8,3709.4,0.8551692801484949,-0.22571806616647747,0.03200519932902732,1.4947794636649703,0.17775532058955976,0.750177391058934,1316]
["O60568","Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 [OS=Homo sapiens]",28,18,49,18,738,84.7,6.05,140.33,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;other membranes;ER/Golgi","other molecular function","PLOD3","ENSG00000106397","Lysine degradation; Other types of O-glycan biosynthesis; Metabolic pathways","Collagen biosynthesis and modifying enzymes","VEGFA-VEGFR2 signaling pathway; IL-18 signaling pathway",5677.5,5613.5,5643.2,5670.6,5357.1,7017.2,0.9384479825324606,-0.09165131511866476,0.5077241248639324,0.2943722003015983,0.6532222546436335,0.1849390276948839,5681]
["O60573","eukaryotic translation initiation factor 4E type 2 [OS=Homo sapiens]",27,6,12,6,245,28.3,8.88,35.32,"protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF4E2","ENSG00000135930","EGFR tyrosine kinase inhibitor resistance; HIF-1 signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Longevity regulating pathway; Insulin signaling pathway","ISG15 antiviral mechanism","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; EGFR tyrosine kinase inhibitor resistance",1367.5,1460.2,1464,2053.8,2003.7,1392.3,0.787496788872986,-0.344654054163908,0.14696353585290922,0.8327904077165763,0.37769215314659405,0.422862037890332,2844]
["O60583-2","Isoform 2 of Cyclin-T2 [OS=Homo sapiens]",4,2,2,2,663,73.6,9.14,4.4,"","","","CCNT2","","","","",29.3,28.3,32.6,36.3,33,33.6,0.8765792031098152,-0.19004364363858786,0.06211758829475781,1.2067854140286494,0.2466145860110727,0.6079812406486911,1841]
["O60610-1","Protein diaphanous homolog 1 [OS=Homo sapiens]",51,64,287,62,1272,141.3,5.41,788.76,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","DIAPH1","ENSG00000131504","Focal adhesion; Regulation of actin cytoskeleton; AGE-RAGE signaling pathway in diabetic complications; Shigellosis","RHOA GTPase cycle; RHOC GTPase cycle; RHO GTPases Activate Formins; RHOB GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; ERBB2 Regulates Cell Motility","Microtubule cytoskeleton regulation; AGE/RAGE pathway; Focal adhesion; Type 2 papillary renal cell carcinoma; Regulation of actin cytoskeleton; G13 signaling pathway",31187.6,31386.6,31132.4,30399,29739.8,31001.7,1.028155430352039,0.04005837897509371,0.0832717601143032,1.079502255566865,0.28668548971994445,0.5425942878488907,2123]
["O60613-1","selenoprotein F [OS=Homo sapiens]",30,4,18,4,162,17.8,5.03,52.18,"","","","","","","","",1730.7,1752,1751.7,1766.6,1898.4,2401,0.8629080118694362,-0.2127213221496264,0.22508375640825742,0.6476558455450361,0.45622217847696994,0.3408236060474462,3606]
["O60637","Tetraspanin-3 [OS=Homo sapiens]",6,2,4,2,253,28,5.81,9.72,"","plasma membrane;other membranes","","TSPAN3","ENSG00000140391","","","",828,720.9,747.8,749.3,750.9,1351.9,0.8052662950106939,-0.312462145248522,0.41371076054105954,0.3833031830377031,0.5901272343471125,0.22905434222637885,5124]
["O60645","exocyst complex component 3 [OS=Homo sapiens]",18,12,32,12,756,86.8,6.11,85.84,"","","","","","","","",2943.7,3135.8,3168,3159.2,2964.1,2478.7,1.0750406882120436,0.10439126406670789,0.37174356728236846,0.4297565378509098,0.5660570277639231,0.24713981334252408,4800]
["O60664-1","Perilipin-3 [OS=Homo sapiens]",58,23,80,23,434,47,5.44,261.45,"transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","PLIN3","ENSG00000105355","","RHOBTB3 ATPase cycle; Late endosomal microautophagy; Triglyceride catabolism; Retrograde transport at the Trans-Golgi-Network; Lipophagy; Chaperone Mediated Autophagy","",11063.3,10605,10507.2,10852.4,10944.6,10650.6,0.9916141717723344,-0.012149204866955997,0.6614876650314253,0.17947824982679472,0.76536541771643,0.11613116483718969,6317]
["O60669","monocarboxylate transporter 2 [OS=Homo sapiens]",5,3,6,3,478,52.2,9.31,15.05,"transport","plasma membrane;other membranes;nucleus","transporter activity","SLC16A7","ENSG00000118596","","Proton-coupled monocarboxylate transport","Male infertility",863.5,869.5,883.6,772.5,884.6,792.5,1.0681743958197256,0.09514720830297424,0.1872339132005316,0.7276154858226844,0.42068634232483415,0.376041587220565,3253]
["O60671-1","Cell cycle checkpoint protein RAD1 [OS=Homo sapiens]",20,4,10,4,282,31.8,4.83,32.83,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RAD1","ENSCCAG00000029737; ENSG00000113456; ENSGGOG00000004219; ENSMFAG00000012657; ENSMMUG00000045918; ENSPANG00000024799; ENSPPAG00000028406; ENSPPYG00000015389; ENSPTRG00000016783","Cellular senescence","Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA)","miRNA regulation of DNA damage response; ATR signaling; DNA damage response",889.8,975.3,935.1,959.4,843,813.7,1.0703719276786055,0.0981121844608965,0.29430868113554404,0.5311969274564233,0.5163471316417887,0.2870582311841774,4166]
["O60674","Tyrosine-protein kinase JAK2 [OS=Homo sapiens]",2,2,2,2,1132,130.6,7.21,5.57,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","JAK2","ENSG00000096968","EGFR tyrosine kinase inhibitor resistance; Chemokine signaling pathway; PI3K-Akt signaling pathway; Necroptosis; Signaling pathways regulating pluripotency of stem cells; JAK-STAT signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; Cholinergic synapse; Prolactin signaling pathway; Adipocytokine signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Leishmaniasis; Toxoplasmosis; Tuberculosis; Hepatitis B; Influenza A; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Pathways in cancer; Chemical carcinogenesis; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis","RMTs methylate histone arginines; Potential therapeutics for SARS; Signaling by BRAF and RAF1 fusions; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Signaling by SCF-KIT; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Interleukin-4 and Interleukin-13 signaling; Cyclin D associated events in G1; Factors involved in megakaryocyte development and platelet production; Growth hormone receptor signaling; Interleukin-6 signaling; Signaling by Leptin; Regulation of IFNG signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; RAF activation; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; Prolactin receptor signaling; IL-6-type cytokine receptor ligand interactions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-12 signaling; Interleukin-23 signaling; Interleukin-27 signaling; Erythropoietin activates Phospholipase C gamma (PLCG); Erythropoietin activates STAT5; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants","IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Mesodermal commitment pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Mesodermal commitment pathway; IL-6 signaling pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; PI3K-Akt signaling pathway; Immune response to tuberculosis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; EGF/EGFR signaling pathway; Overview of interferons-mediated signaling pathway; Gastrin signaling pathway; Hepatitis B infection; EGFR tyrosine kinase inhibitor resistance; mBDNF and proBDNF regulation of GABA neurotransmission; 16p11.2 distal deletion syndrome; CCL18 signaling pathway; EPO receptor signaling; Notch signaling pathway (Netpath); Type II interferon signaling (IFNG); Serotonin receptor 2 and STAT3 signaling",39,34.3,35.3,39.7,33.7,33.3,1.0178069353327084,0.025463926979936404,0.8136241775599369,0.08957615445004405,0.8768474069279827,0.057075978008138586,6782]
["O60678","protein arginine N-methyltransferase 3 [OS=Homo sapiens]",7,3,4,3,531,59.8,5.35,11.5,"","","","","","","","",176.3,178.3,193.8,186.8,189.4,173.7,0.9972722313147845,-3.9407154818160445E-3,0.9491058438742904,0.02268535253865105,0.9696693615987124,0.013376326467628848,7154]
["O60683-1","Peroxisome biogenesis factor 10 [OS=Homo sapiens]",11,2,2,2,326,37,9.99,7.37,"cell organization and biogenesis;transport","other membranes;other cytoplasmic organelle","other molecular function","PEX10","ENSG00000157911","Peroxisome","E3 ubiquitin ligases ubiquitinate target proteins; Peroxisomal protein import","Male infertility",240.1,243.3,231.1,233.5,222.1,712.8,0.6115200273878808,-0.7095283468460001,0.40251828187660516,0.3952143897363122,0.5831528488079498,0.2342175984252686,5045]
["O60684","Importin subunit alpha-7 [OS=Homo sapiens]",40,20,64,15,536,60,4.98,212.03,"transport;other biological processes","nucleus;other cell component","other molecular function","KPNA6","ENSG00000025800","Nucleocytoplasmic transport; Influenza A; Chemical carcinogenesis","Assembly of the ORC complex at the origin of replication","",6779.4,6941.1,7053.5,7048.3,7090.5,5137.5,1.0776964458946998,0.10795087227116763,0.48464428399349924,0.31457690506578734,0.6361826637407482,0.19641816978432008,5568]
["O60701","UDP-glucose 6-dehydrogenase [OS=Homo sapiens]",27,10,21,10,494,55,7.12,73.03,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes","cytosol;nucleus","other molecular function","UGDH","ENSG00000109814","Pentose and glucuronate interconversions; Ascorbate and aldarate metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars","Formation of the active cofactor, UDP-glucuronate","Glucuronidation",1998.8,2033.6,2040.2,2047.8,1980.8,2457.5,0.9362482847936355,-0.09503692433010746,0.40885699465408293,0.38842856801414694,0.5866383537351182,0.23162954675777028,5094]
["O60704","Protein-tyrosine sulfotransferase 2 [OS=Homo sapiens]",7,2,2,2,377,41.9,9.09,6.91,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","TPST2","ENSG00000128294","","Cytosolic sulfonation of small molecules; Gamma carboxylation, hypusine formation and arylsulfatase activation; Defective F8 sulfation at Y1699","",259,276.4,263,266.2,271.7,232.7,1.0360757851025177,0.05112953467771085,0.5235793627474051,0.28101747980950903,0.6651906070434181,0.17705389195103532,5753]
["O60711-1","Leupaxin [OS=Homo sapiens]",36,11,87,11,386,43.3,6.01,336.59,"cell adhesion;cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","LPXN","ENSG00000110031","","","",7910.1,7530.9,7501.4,7934.7,7964.5,9958.9,0.8872422954509419,-0.17259995348277593,0.2276141507219372,0.642800741444745,0.458174560073434,0.33896902847366434,3631]
["O60725","protein-s-isoprenylcysteine O-methyltransferase [OS=Homo sapiens]",6,2,3,2,284,31.9,7.96,7.07,"protein metabolism;other metabolic processes;transport","other membranes;ER/Golgi","other molecular function","ICMT","ENSG00000116237","Terpenoid backbone biosynthesis","RAS processing; Gamma carboxylation, hypusine formation and arylsulfatase activation","Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome",545.8,556.9,586.6,503.6,502.5,1101.3,0.801603872069849,-0.31903861753877544,0.5238660698129334,0.280779729382192,0.665323562860596,0.1769670954640296,5755]
["O60733","85/88 kDa calcium-independent phospholipase A2 [OS=Homo sapiens]",1,1,1,1,806,89.8,7.27,2.59,"other metabolic processes;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component","other molecular function","PLA2G6","ENSG00000184381","Glycerophospholipid metabolism; Ether lipid metabolism; Arachidonic acid metabolism; Linoleic acid metabolism; alpha-Linolenic acid metabolism; Metabolic pathways; Ras signaling pathway; Vascular smooth muscle contraction; Fc gamma R-mediated phagocytosis; Inflammatory mediator regulation of TRP channels","Role of phospholipids in phagocytosis; COPI-independent Golgi-to-ER retrograde traffic; Acyl chain remodelling of PC; Acyl chain remodelling of PE; Acyl chain remodeling of CL","Eicosanoid synthesis; Spinal cord injury; Ras signaling; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Eicosanoid metabolism via cyclooxygenases (COX); Omega-3 / omega-6 fatty acid synthesis",210,179.1,206.1,191.3,201.7,76.9,1.2666524792509046,0.341020758706916,0.36744327501134927,0.43480969671864755,0.5633821894394696,0.2491968867617166,4767]
["O60749","Sorting nexin-2 [OS=Homo sapiens]",43,20,66,18,519,58.4,5.12,199.82,"cell organization and biogenesis;transport","other membranes;cytosol;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","SNX2","ENSG00000205302","Endocytosis","Golgi Associated Vesicle Biogenesis","",7782.7,8027.6,7993.3,7414.6,7304.2,6584.4,1.1173720380036802,0.16010962272140628,0.037223119527185274,1.429187233121665,0.18880206844149697,0.7239932520516814,1441]
["O60759","cytohesin-interacting protein [OS=Homo sapiens]",12,2,3,2,359,40,6.99,8.96,"other biological processes","cytosol;nucleus;other cytoplasmic organelle;other cell component","","CYTIP","ENSG00000115165","","","Amplification and expansion of oncogenic pathways as metastatic traits",203,234.3,210.4,227.7,247.2,187.2,0.9782510194834619,-0.031723386257108424,0.8224425184412769,0.08489444571370187,0.8832254433275482,0.05392842858951952,6806]
["O60762","Dolichol-phosphate mannosyltransferase subunit 1 [OS=Homo sapiens]",47,10,50,10,260,29.6,9.57,123.59,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","DPM1","ENSG00000000419","N-Glycan biosynthesis; Metabolic pathways","Synthesis of dolichyl-phosphate mannose; Defective DPM1 causes DPM1-CDG (CDG-1e); Defective DPM3 causes DPM3-CDG (CDG-1o); Defective DPM2 causes DPM2-CDG (CDG-1u)","VEGFA-VEGFR2 signaling pathway",7442.6,6949.6,7083.2,7693.1,6668,5618.6,1.0748609838986571,0.10415008231805775,0.46417222523352913,0.3333208500685936,0.6213616839252499,0.2066555308893578,5460]
["O60763-1","General vesicular transport factor p115 [OS=Homo sapiens]",48,41,195,41,962,107.8,4.91,605.23,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","","USO1","ENSG00000138768","","COPI-mediated anterograde transport; COPII-mediated vesicle transport; Golgi Cisternae Pericentriolar Stack Reorganization","",21548.2,21277.9,21330.6,21250.5,21834.1,16130,1.0834608356722837,0.115647004652105,0.415131471264427,0.38181434135435016,0.5911155120731925,0.22832764373113995,5133]
["O60783","28S ribosomal protein S14, mitochondrial [OS=Homo sapiens]",12,1,3,1,128,15.1,11.41,11.73,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus","other molecular function","MRPS14","ENSG00000120333","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",40.5,40.4,31.8,31.4,43.4,77.3,0.7409598948060487,-0.4325326375522755,0.40261790285068144,0.3951069176331708,0.5829505253438254,0.23436830198527572,5048]
["O60784","Target of Myb protein 1 [OS=Homo sapiens]",57,19,81,19,492,53.8,4.7,205.96,"transport;signal transduction","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","TOM1","ENSG00000100284","","Neutrophil degranulation","",4556.4,4655.9,4514.7,4893,4972.1,6049.1,0.8625629940556233,-0.21329827243616362,0.12394998631492904,0.9067535168457453,0.34951792051536124,0.4565305521603281,2592]
["O60825-1","6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 [OS=Homo sapiens]",46,19,72,1,505,58.4,8.38,198.67,"other metabolic processes;other biological processes","cytosol;nucleus","kinase activity;other molecular function","PFKFB2","ENSG00000123836; ENSGGOG00000012227; ENSPPAG00000041619; ENSPTRG00000001925","Fructose and mannose metabolism; Metabolic pathways; AMPK signaling pathway; Thyroid hormone signaling pathway","Regulation of glycolysis by fructose 2,6-bisphosphate metabolism","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Thyroid hormones production and peripheral downstream signaling effects",4895.6,5060.4,5083.2,5229.1,4670.4,5312.8,0.988621050071324,-0.016510469706262493,0.797218308038948,0.09842273632755728,0.8646488519745764,0.06316023081528668,6739]
["O60825-2","Isoform 2 of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 [OS=Homo sapiens]",50,19,71,1,471,54.4,7.56,198.67,"","","","PFKFB2","","","","",133.8,126.1,146.7,125.4,114.2,134.1,1.088038533583088,0.12172965146398787,0.2580745124298599,0.5882548844822701,0.48577558881015864,0.31356431314434485,3883]
["O60826","Coiled-coil domain-containing protein 22 [OS=Homo sapiens]",26,14,30,14,627,70.7,6.74,85.37,"transport;other biological processes","cytosol;nucleus;other cytoplasmic organelle","other molecular function","CCDC22","ENSG00000101997","","Neddylation","",2419.4,2425,2428.6,2573.7,2576.3,2127.6,0.9993679234912609,-9.1218195939363981E-4,0.9922902886713445,0.003361258969112042,0.9962430933927001,1.6346763981762702E-3,7280]
["O60828","Polyglutamine-binding protein 1 [OS=Homo sapiens]",19,4,9,4,265,30.5,6.33,27.86,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","PQBP1","ENSG00000102103","Spliceosome","mRNA Splicing - Major Pathway","",686.2,788.2,713.7,937,943.8,1001.3,0.7592033586620869,-0.39744172013316265,3.2266437198925184E-3,2.491248985952434,0.060315956390522805,1.2195677814643278,391]
["O60830-1","Mitochondrial import inner membrane translocase subunit Tim17-B [OS=Homo sapiens]",30,5,15,5,172,18.3,9.03,43.72,"cell organization and biogenesis;transport","other membranes;mitochondrion","transporter activity","TIMM17B","ENSG00000126768; ENSGGOG00000011427; ENSNLEG00000007902; ENSPPAG00000036547; ENSPPYG00000020323; ENSPTRG00000021872","","Mitochondrial protein import","",1870.2,1886.7,1916.2,1912.9,2016.6,1980.8,0.9598666734345127,-0.05909406710879294,0.07617972369938594,1.1181606068398093,0.27347622815265804,0.5630804186205575,2036]
["O60831","PRA1 family protein 2 [OS=Homo sapiens]",22,3,7,3,178,19.2,9.19,15.69,"transport","other membranes;other cytoplasmic organelle","","PRAF2","ENSG00000243279","","","",397.6,347.7,385.6,325.1,345,536.4,0.9373394115209284,-0.09335655110871333,0.7335149192478136,0.1345910484449573,0.8186380431794579,0.08690807698978599,6549]
["O60832-1","H/ACA ribonucleoprotein complex subunit 4 [OS=Homo sapiens]",53,27,113,27,514,57.6,9.42,378.31,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DKC1","ENSG00000130826; ENSGGOG00000001045; ENSPTRG00000022449","Ribosome biogenesis in eukaryotes","rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase","",17471.9,17203.1,16663,17538.2,16910.5,17734.1,0.9838107575676277,-0.0235472644605831,0.4588719592689489,0.33830848034596134,0.6181155824358178,0.20893030788756575,5426]
["O60841","Eukaryotic translation initiation factor 5B [OS=Homo sapiens]",41,55,214,54,1220,138.7,5.49,606.45,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","EIF5B","ENSG00000158417","","GTP hydrolysis and joining of the 60S ribosomal subunit","Translation factors; Ciliary landscape",27924.1,28385.8,28542.3,28722.6,29131.3,18313.4,{"$f":"AVERAGE(S514:U514)/AVERAGE(V514:X514)","v":1.1140239971746408},{"$f":"LOG(Y514,2)","v":0.15578031008545462},{"$f":"TTEST(V514:X514,S514:U514,2,2)","v":0.4599428587546941},0.33729611977273893,{"$f":"AA514*7309/AE514","v":0.6185321719665242},0.20863770631107934,5435]
["O60861-1","Isoform 1 of Growth arrest-specific protein 7 [OS=Homo sapiens]",7,2,3,2,412,47.2,7.58,8.59,"","","","GAS7","","","","",265.7,298,284.9,580.2,576.6,168,0.6405495169082125,-0.6426179942085892,0.31144947051478644,{"$f":"-LOG10(AA515)","v":0.5066124031192734},0.5297612706522165,{"$f":"-LOG10(AC515)","v":0.2759197949192036},4297]
["O60869-1","Endothelial differentiation-related factor 1 [OS=Homo sapiens]",10,1,1,1,148,16.4,9.95,2.52,"developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","EDF1; LOC101354658; LOC113248658","ENSBIXG00000009641; ENSBIXG00005005090; ENSBTAG00000030302; ENSCATG00000040060; ENSCCAG00000020655; ENSCJAG00000011166; ENSCSAG00000016077; ENSECAG00000012630; ENSFCAG00000000388; ENSG00000107223; ENSLCNG00005013346; ENSPANG00000026162; ENSPCOG00000009350; ENSRFEG00010005371","","","",223,267.5,256.4,225.5,236.7,207.8,1.114776119402985,0.15675400264953188,0.18002414846463785,0.7446692346661005,0.4137724846314585,0.3832383927665602,3180]
["O60870","DNA/RNA-binding protein KIN17 [OS=Homo sapiens]",13,5,13,5,393,45.3,8.95,36.4,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response","nucleus;other cell component","nucleic acid binding activity;other molecular function","KIN","ENSG00000151657","","Protein methylation","",698.7,682.4,704,1031.1,998.5,1108,0.6645525242223356,-0.589544864625279,4.4871787752100238E-4,3.3480266272486214,0.022934817949657387,1.6395047028297103,143]
["O60879-2","Isoform 2 of Protein diaphanous homolog 2 [OS=Homo sapiens]",18,20,36,18,1096,124.7,6.43,109.53,"","","","DIAPH2","","","","",3608.5,3802.5,3806.3,3666.3,3801.7,2043.3,1.1793655967112804,0.23801101501102134,0.37391335697400807,0.4272290206534939,0.5675872743765369,0.24596735023007424,4815]
["O60884","DnaJ homolog subfamily A member 2 [OS=Homo sapiens]",37,14,52,14,412,45.7,6.48,156.08,"stress response;other biological processes","other membranes;cytosol","other molecular function","DNAJA2","ENSG00000069345","Protein processing in endoplasmic reticulum","HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand","",6362.4,6299.4,6357.8,6382.7,6463.7,6425.5,0.9869084003134094,-0.019011907415575187,0.05318125828858908,1.2742413913119732,0.22811139485404786,0.6418530198586816,1704]
["O60885-1","Bromodomain-containing protein 4 [OS=Homo sapiens]",4,5,6,5,1362,152.1,9.19,12.26,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","kinase activity;other molecular function","BRD4","ENSG00000141867; ENSPTRG00000010619","","Potential therapeutics for SARS","VEGFA-VEGFR2 signaling pathway; 7q11.23 copy number variation syndrome",331,364.5,325.6,2149.6,2182.1,1282.2,0.1818878141755286,-2.4588792040004006,6.5588954658804995E-3,2.183169290725201,0.08308313164665611,1.0804871419969597,577]
["O60888-1","Protein CutA [OS=Homo sapiens]",47,5,48,5,179,19.1,5.5,156.55,"other biological processes","other membranes","other molecular function","CUTA","ENSG00000112514; ENSG00000226492","","","",2346.4,1971.6,2408.2,2634.6,3118.3,2518.3,0.8132072734306992,-0.29830497599656036,0.08757372305415984,1.057626186577501,0.29334387800314127,0.5326229709458511,2182]
["O60906","Sphingomyelin phosphodiesterase 2 [OS=Homo sapiens]",6,2,3,2,423,47.6,6.98,6.62,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","SMPD2","ENSG00000135587","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway","Glycosphingolipid metabolism; Ceramide signalling; TNFR1-mediated ceramide production","TNF-alpha signaling pathway; S1P receptor signal transduction",67,70.6,72.3,55.9,68.3,219.4,0.6108847497089638,-0.7110278698463096,0.44438941571788504,0.35223629345317287,0.6083615357711223,0.21583825242710877,5339]
["O60907","F-box-like/WD repeat-containing protein TBL1X [OS=Homo sapiens]",14,7,25,2,577,62.5,6.55,91.11,"protein metabolism;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","TBL1X","ENSG00000101849","Wnt signaling pathway","Heme signaling; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; RORA activates gene expression","Ectoderm differentiation; Ectoderm differentiation; Rett syndrome causing genes",48.8,48.6,43.4,63.8,61,102.8,0.6186291739894553,-0.6928532236692845,0.10060548173268843,0.9973783550514835,0.3145104644928228,0.5023648999933318,2338]
["O60921","checkpoint protein HUS1 [OS=Homo sapiens]",20,4,9,4,280,31.7,6.84,31.78,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","","HUS1","ENSG00000136273","Cellular senescence","Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA)","ATR signaling",366.9,409,371.9,358.7,362,307.9,1.1158856698425044,0.1581892207148113,0.14486350653112087,0.8390410065805247,0.37440147427014225,0.4266624498214136,2828]
["O60925","prefoldin subunit 1 [OS=Homo sapiens]",8,1,1,1,122,14.2,6.81,3.51,"other biological processes","other cell component","other molecular function","PFDN1","ENSG00000113068","","Prefoldin mediated transfer of substrate  to CCT/TriC","Cellular proteostasis",109.4,110.8,97.8,134.5,170.2,154.9,0.691906005221932,-0.5313520324743958,0.013259967612358169,1.877457536699821,0.11935603852059835,0.9231556040570231,812]
["O60927","Protein phosphatase 1 regulatory subunit 11 [OS=Homo sapiens]",12,1,2,1,126,13.9,7.01,8.98,"protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","enzyme regulator activity;other molecular function","PPP1R11","ENSG00000204619; ENSG00000206501; ENSG00000227720; ENSG00000233314; ENSG00000234058; ENSG00000236560; ENSG00000237403; ENSG00000237829","","","",109.6,107.7,80.8,154.3,154.1,211.2,0.5737105465742881,-0.8016050554567118,0.025115873865285715,1.6000517066834428,0.15716774150802507,0.8036365875758505,1168]
["O60930","Ribonuclease H1 [OS=Homo sapiens]",7,2,3,2,286,32,9.16,10.07,"RNA metabolism OR transcription;other metabolic processes","other cell component","nucleic acid binding activity;other molecular function","RNASEH1","ENSG00000171865","DNA replication","","",418.2,421,396.7,415.2,389.8,467.9,0.9709325163013591,-0.04255706884195856,0.6377685673871804,0.19533688889784306,0.7478662696988451,0.1261760539058687,6233]
["O60934","Nibrin [OS=Homo sapiens]",12,7,14,7,754,84.9,6.9,28.06,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NBN","ENSG00000104320","Homologous recombination; Cellular senescence","Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks","miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM signaling in development and disease ; Breast cancer pathway; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; DNA damage response",1276.6,1232.7,1193.4,1486.5,1639.8,1418.9,0.8146396198187098,-0.2957661136837885,0.015689066150362058,1.8044029058594975,0.12698935159800254,0.8962326942890304,903]
["O60942-1","mRNA-capping enzyme [OS=Homo sapiens]",19,10,25,10,597,68.5,8.13,62.35,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","RNGTT","ENSG00000111880; ENSGGOG00000007863; ENSNLEG00000013064; ENSPPAG00000024828; ENSPTRG00000018413","mRNA surveillance pathway","RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE","mRNA processing; Ciliary landscape; mRNA Processing",1778.9,1737.1,1789,1834.7,1902.7,2316.3,0.8763235707088225,-0.19046443092391313,0.17444307807614892,0.7583462587350688,0.4069596098495284,0.39044869173280095,3133]
["O75027-1","ATP-binding cassette sub-family B member 7, mitochondrial [OS=Homo sapiens]",26,17,33,16,752,82.6,9.33,94.31,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","ABCB7","ENSG00000131269","ABC transporters","Mitochondrial ABC transporters; Cytosolic iron-sulfur cluster assembly","",3371.2,3666.5,3778.9,2939,3176.3,3174.4,1.1643648341711788,0.21954317334954263,0.02460040312385897,1.6090577761066613,0.15513748613657052,0.8092832501862843,1159]
["O75037","Kinesin-like protein KIF21B [OS=Homo sapiens]",8,10,15,9,1637,182.5,7.08,40.29,"other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF21B","ENSG00000116852","","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",831,864.4,841.9,1111.7,1013.6,2361,0.5655662795622228,-0.822231989164722,0.2086035515573467,0.6806783018125196,0.4446437323804745,0.3519878250434908,3429]
["O75044","SLIT-ROBO Rho GTPase-activating protein 2 [OS=Homo sapiens]",31,28,60,28,1071,120.8,6.7,171.11,"","","","","","","","",7206.1,7482.1,7575.2,6965.9,6721.1,6491.6,1.1033173758338042,0.14184785047576035,0.016892861027687712,1.7722967907302258,0.13247845627829344,0.8778547412002343,932]
["O75052","Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein [OS=Homo sapiens]",12,5,15,4,506,56.1,6.3,29.74,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","NOS1AP","ENSG00000198929","Circadian entrainment","","Sudden infant death syndrome (SIDS) susceptibility pathways",403.8,411.9,382.8,401.4,400,780.2,0.7577769347496207,-0.40015486719271254,0.37085601052721334,0.4307946779097063,0.5662391019309384,0.24700014350768196,4787]
["O75063","Glycosaminoglycan xylosylkinase [OS=Homo sapiens]",15,5,12,5,409,46.4,6.87,36.6,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;nucleus","kinase activity;other molecular function","FAM20B","ENSG00000116199","","","",823.6,853.1,808.7,863.6,888.8,1116.4,0.8663552704963747,-0.20696933566559814,0.19170628289260686,0.7173636535232117,0.42615000658821883,0.3704375005072516,3288]
["O75064","DENN domain-containing protein 4B [OS=Homo sapiens]",4,5,8,5,1496,163.7,7.21,29.61,"other biological processes","cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity","DENND4B","ENSG00000198837","","RAB GEFs exchange GTP for GDP on RABs","",504.4,505.3,485.7,523.3,483.8,1231.7,0.6679471145256387,-0.5821942146910163,0.36562468312686325,0.4369644929602452,0.5622450681620542,0.25007434537103074,4753]
["O75071","EF-hand calcium-binding domain-containing protein 14 [OS=Homo sapiens]",3,2,2,2,495,55,6.32,2.24,"","","other molecular function","EFCAB14","ENSG00000159658","","","",218.4,214.6,195.8,210.3,222.6,379.4,0.7740982395666626,-0.36941142678393524,0.3274829834584698,0.48481126172437333,0.5400661385600081,0.26755305156077375,4432]
["O75083","WD repeat-containing protein 1 [OS=Homo sapiens]",66,28,263,28,606,66.2,6.65,1018.95,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity","WDR1","ENSG00000071127","","Platelet degranulation","Hypertrophy model",30182.3,29958.5,29201.5,28306.9,25728,25594,1.1219833502660468,0.16605126715273769,0.025434189953598474,1.5945820895358456,0.1578085690754255,0.8018694181029554,1178]
["O75093-1","Slit homolog 1 protein [OS=Homo sapiens]",1,1,1,1,1534,167.8,6.57,1.87,"cell organization and biogenesis;transport;developmental processes;other biological processes","non-structural extracellular","signal transduction activity or receptor binding;other molecular function","SLIT1","ENSG00000187122","Axon guidance","Regulation of expression of SLITs and ROBOs; Netrin-1 signaling; Regulation of cortical dendrite branching; Regulation of commissural axon pathfinding by SLIT and ROBO","Spinal cord injury",244.3,252.5,253.2,273.9,262.7,391.5,0.8081025751535397,-0.3073896641963823,0.223894359425728,0.6499568474711623,0.45621518623993473,0.340830262263156,3587]
["O75113","NEDD4-binding protein 1 [OS=Homo sapiens]",19,12,17,12,896,100.3,5.36,60.04,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","N4BP1","ENSG00000102921","","","",891.3,909.5,882.6,937.6,904.2,834.9,1.0025030821533978,0.003606672192002866,0.9464839202834413,0.023886759821147175,0.9679377323844511,0.014152580038341307,7147]
["O75116","Rho-associated protein kinase 2 [OS=Homo sapiens]",29,34,65,28,1388,160.8,6.02,166.7,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;kinase activity;other molecular function","ROCK2","ENSG00000134318","cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Vascular smooth muscle contraction; Wnt signaling pathway; Axon guidance; Focal adhesion; Tight junction; Platelet activation; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Human cytomegalovirus infection; Pathways in cancer; Proteoglycans in cancer; Lipid and atherosclerosis","RHOA GTPase cycle; RHOB GTPase cycle; RHOC GTPase cycle; G alpha (12/13) signalling events; Potential therapeutics for SARS; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHOBTB1 GTPase cycle; RHOH GTPase cycle","Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Pathogenic Escherichia coli infection; Spinal cord injury; Focal adhesion; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; Wnt signaling; Airway smooth muscle cell contraction; Regulation of actin cytoskeleton; G13 signaling pathway",5169.7,5104.9,5223.6,5494.7,5485.7,4088.7,1.0284754895780108,0.04050741225311481,0.7753335423842109,0.11051142722968725,0.8487214110058706,0.07123484157919688,6677]
["O75122","CLIP-associating protein 2 [OS=Homo sapiens]",29,29,71,1,1294,141,8.47,187.27,"","","","","","","","",17.2,15.1,25.9,16,21.4,30.2,0.8609467455621301,-0.21600409337390056,0.585953318560537,0.23213698176196718,0.7108270216363428,0.14823607112490017,6025]
["O75122-3","Isoform 3 of CLIP-associating protein 2 [OS=Homo sapiens]",24,29,71,1,1515,165.8,8.37,188.79,"","","","","","","","",5219.8,5104.8,5187.9,5824.7,5843.1,7082.7,0.8273112716994213,-0.2734978566076946,0.06107332636762156,1.2141484254477024,0.24419307572261817,0.612266654961542,1828]
["O75127","pentatricopeptide repeat-containing protein 1, mitochondrial [OS=Homo sapiens]",15,8,17,8,700,78.8,8.59,43.17,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","nucleic acid binding activity","PTCD1","ENSG00000106246","","","",1392.5,1380.3,1494.9,1658.4,1671.1,1816.2,0.8293720970907749,-0.26990858401426465,0.009329112444321826,2.030159672316614,0.10177086993365408,0.9923765131334678,670]
["O75131","Copine-3 [OS=Homo sapiens]",46,20,84,19,537,60.1,5.85,274.59,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","CPNE3","ENSG00000085719","","Neutrophil degranulation; Glycerophospholipid biosynthesis","",10534.6,10343.8,10419,9807.3,9514,11112.7,1.028369586646514,0.04035884915909542,0.5917829844557998,0.2278375262710103,0.7143421690152668,0.14609371186610842,6055]
["O75132","Zinc finger BED domain-containing protein 4 [OS=Homo sapiens]",2,2,2,2,1171,130.2,6.83,7.41,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBED4","ENSG00000100426","","","",121.5,120.7,119.6,140.7,137,218.8,0.7287009063444108,-0.45660130979449554,0.16764552455133833,0.7756080359637713,0.3995178151110961,0.39846385006228385,3067]
["O75140-1","Isoform 1 of GATOR complex protein DEPDC5 [OS=Homo sapiens]",8,9,10,9,1572,177.8,6.73,33.77,"","","","DEPDC5","","","","",683.3,662.5,674.1,700.4,665.7,851.7,0.9107674271800883,-0.13484539924733538,0.31463413792911304,0.5021941580321868,0.5325754780277645,0.27361883414642585,4318]
["O75143-1","Autophagy-related protein 13 [OS=Homo sapiens]",17,5,9,5,517,56.5,5.12,27.52,"cell organization and biogenesis;other metabolic processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cell component","other molecular function","ATG13","ENSG00000175224","Autophagy; Autophagy; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration","Macroautophagy","Alzheimer's disease and miRNA effects; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Host-pathogen interaction of human coronaviruses - autophagy; Autophagy; Malignant pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; Senescence and autophagy in cancer",760.8,714.4,682.6,939.2,911.7,1145.8,0.7200587312710647,-0.47381351075202327,0.022395613263620783,1.6498370406825733,0.14880867031254938,0.8273717639568254,1100]
["O75144-1","ICOS ligand [OS=Homo sapiens]",4,1,1,1,302,33.3,5.31,2.94,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","ICOSLG","ENSG00000160223","Cell adhesion molecules; Intestinal immune network for IgA production","Costimulation by the CD28 family","",80.1,80.6,81.9,88.8,92.6,147,0.738733252131547,-0.4368745766572944,0.2029604700468801,0.6925885399796157,0.4384978053717548,0.3580325758836233,3383]
["O75145-1","Liprin-alpha-3 [OS=Homo sapiens]",1,2,2,1,1194,133.4,5.68,4.59,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","non-structural extracellular;cytosol;other cell component","","PPFIA3","ENSG00000177380","","Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Receptor-type tyrosine-protein phosphatases","",278.4,291.5,291.9,330,301.1,639.1,0.6784758305778616,-0.5596306716183631,0.27700592629030446,0.5575109395000077,0.5031402373896211,0.29831094966390576,4024]
["O75146","Huntingtin-interacting protein 1-related protein [OS=Homo sapiens]",25,25,37,25,1068,119.3,6.67,110.28,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component","cytoskeletal activity;other molecular function","HIP1R","ENSG00000130787","","Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis","",3438.7,3375.7,3544.4,3500.6,3424.6,5411.7,0.8396598821421912,-0.25212303570262573,0.36903197645917346,0.4329360007837782,0.5651067915231718,0.2478694732660492,4773]
["O75150","E3 ubiquitin-protein ligase BRE1B [OS=Homo sapiens]",39,36,87,33,1001,113.6,6.23,274.24,"protein metabolism;other metabolic processes","nucleus","other molecular function","RNF40","","","","",7148.4,7208.5,7473.2,7649.3,7730.5,8338.4,0.9203944650099924,-0.11967578725609196,0.05813814359364636,1.2355388397810574,0.23832399973413418,0.6228322210724391,1783]
["O75151","lysine-specific demethylase phf2 [OS=Homo sapiens]",7,6,6,6,1096,120.7,9.17,14.18,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","other molecular function","PHF2","ENSG00000197724","","HDMs demethylate histones","",285.2,297.8,298.8,321.9,347,450.6,0.7876730683340777,-0.34433114612421234,0.11621382558859905,0.93474220224119,0.3390845713481319,0.46969197056048156,2505]
["O75152","Zinc finger CCCH domain-containing protein 11A [OS=Homo sapiens]",35,26,48,26,810,89.1,8.37,125.72,"other metabolic processes;transport","nucleus","nucleic acid binding activity;other molecular function","ZC3H11A","ENSG00000058673","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","",5833.6,5766.7,5908.4,6431.8,6612.9,5477.3,0.9452920850880033,-0.08116791941732428,0.39479319104750504,0.4036303461644988,0.5787291282322933,0.23752465844828047,4986]
["O75153","Clustered mitochondria protein homolog [OS=Homo sapiens]",24,22,46,22,1309,146.6,6.13,135.35,"cell organization and biogenesis","other cell component","nucleic acid binding activity","CLUH","ENSG00000132361","","","Translation factors",4635.7,4552.9,4578.1,6413.4,6103.6,4640.8,0.802358111179755,-0.317681805949632,0.10772650724160367,0.9676774208215667,0.32562987652145625,0.48727575546234675,2418]
["O75157","TSC22 domain family protein 2 [OS=Homo sapiens]",6,5,11,3,780,79.2,5.02,19.03,"stress response;other biological processes","","","TSC22D2","ENSG00000196428","","","",573.5,605.4,593,571.1,605.2,538.3,1.0334188732065785,0.047425136884798956,0.42313611555205444,0.3735199051447524,0.5944074319757766,0.22591576915681605,5203]
["O75164-1","Lysine-specific demethylase 4A [OS=Homo sapiens]",12,9,18,9,1064,120.6,5.85,58.62,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","KDM4A","ENSG00000066135","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux","",949.6,905.9,894.7,1137.1,1113.6,1404.9,0.7523251996936207,-0.41057167956638685,0.03354980351733409,1.4743100189104128,0.18150667202679116,0.7411074060484704,1351]
["O75165","DnaJ homolog subfamily C member 13 [OS=Homo sapiens]",30,57,155,57,2243,254.3,6.74,473.49,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","","DNAJC13","ENSG00000138246","","Neutrophil degranulation","",14913.2,14813.4,14695.1,14905.2,14569.8,18052.4,0.9346545361202169,-0.0974948754733049,0.4041825527119485,0.3934224375413132,0.5839435219947878,0.2336291550659075,5059]
["O75167","Phosphatase and actin regulator 2 [OS=Homo sapiens]",2,2,2,1,634,69.7,8.16,3.9,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes","enzyme regulator activity;cytoskeletal activity","PHACTR2","ENSG00000112419","","Platelet degranulation","",47.6,48.9,54.7,52.1,47.1,204.9,0.4972048668201249,-1.0080876768097253,0.3811347427023255,0.41892146089411664,0.5700253395562302,0.24410583803831548,4887]
["O75170","Serine/threonine-protein phosphatase 6 regulatory subunit 2 [OS=Homo sapiens]",25,14,27,14,966,104.9,4.87,59.4,"other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP6R2","ENSG00000100239","","","",1021,1097.5,997.1,1037.9,1065.8,952.8,1.0193358416489449,0.027629456072435263,0.6874732521088807,0.16274419449769495,0.7862215615183553,0.10445505016227775,6391]
["O75175","CCR4-NOT transcription complex subunit 3 [OS=Homo sapiens]",7,5,14,5,753,81.8,6.2,35.81,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","","CNOT3","ENSG00000088038; ENSG00000273943; ENSG00000274176; ENSG00000274616; ENSG00000274941; ENSG00000275979; ENSG00000276082; ENSG00000277114; ENSG00000277600; ENSG00000277615","RNA degradation","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","",839.5,870.8,820.3,1192.6,1226.6,1051.6,0.729111444047482,-0.4557887488036155,0.004862089582434706,2.3131770436830044,0.07267282772600259,1.1386279409226514,489]
["O75177","Calcium-responsive transactivator [OS=Homo sapiens]",6,2,2,2,396,43,6.44,5.82,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","SS18L1","ENSG00000184402","","","",182.9,196.3,172,218.1,211.6,225.2,0.8416552145365706,-0.24869874300765576,0.012706514283133904,1.8959735710212833,0.11623518510065796,0.9346623884513018,799]
["O75179-1","Ankyrin repeat domain-containing protein 17 [OS=Homo sapiens]",14,29,48,17,2603,274.1,6.52,133.09,"stress response;developmental processes;other biological processes","other membranes;nucleus;other cell component","other molecular function","ANKRD17","ENSG00000132466","","","",3973.8,4035.2,4051.5,4840.6,4741.1,4272.8,0.8705113861922118,-0.20006492659673236,0.027650162364621256,1.558302314129553,0.16443859782182,0.7839962351320341,1229]
["O75182-2","Isoform 2 of Paired amphipathic helix protein Sin3b [OS=Homo sapiens]",8,6,10,5,1130,129.3,6.98,26.85,"","","","SIN3B","","","","",176.6,156.6,160.1,191.9,203.3,184.1,0.8515449680649056,-0.23184537767731447,0.026093314128345476,1.5834707573794573,0.1594615660234758,0.7973439751478764,1196]
["O75190","DnaJ homolog subfamily B member 6 [OS=Homo sapiens]",30,8,18,7,326,36.1,9.16,53.64,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","DNAJB6","ENSG00000105993","","Regulation of HSF1-mediated heat shock response","",1643,1631.3,1649.6,1596.8,1618.9,1495.7,1.0451033663030098,0.06364563960550995,0.13807537277637555,0.8598837755929375,0.364592810557272,0.4381918994936847,2768]
["O75191","xylulose kinase [OS=Homo sapiens]",4,2,2,2,536,58.3,5.86,6.13,"other metabolic processes","cytosol","kinase activity;other molecular function","XYLB","ENSG00000093217","Pentose and glucuronate interconversions; Metabolic pathways","Formation of xylulose-5-phosphate","",170.8,173.6,176.7,161.6,138.9,299.8,0.8680659670164916,-0.20412341319534857,0.6274822984315997,0.20239852132407637,0.7404372165380307,0.13051176046087137,6194]
["O75208-1","Ubiquinone biosynthesis protein COQ9, mitochondrial [OS=Homo sapiens]",18,4,13,4,318,35.5,5.94,59.67,"other metabolic processes","other membranes;mitochondrion","other molecular function","COQ9","ENSG00000088682","","Ubiquinol biosynthesis","",777.5,856.9,875.3,644.7,741.2,613.2,1.2554149367215246,0.3281642790853088,0.025203421810251946,1.5985404920587096,0.15731153715724291,0.8032394252470998,1171]
["O75223-1","gamma-glutamylcyclotransferase [OS=Homo sapiens]",54,9,45,9,188,21,5.14,115.66,"cell organization and biogenesis;signal transduction","cytosol","other molecular function","C7orf24; GGCT","ENSG00000006625; ENSGGOG00000024930; ENSPPAG00000031715; ENSPTRG00000019041","Glutathione metabolism; Metabolic pathways","Glutathione synthesis and recycling","Gamma-glutamyl cycle for the biosynthesis and degradation of glutathione, including diseases",5261.4,5484.3,5198.5,5184.2,4634.5,3910,1.1613772607748731,0.21583669213370935,0.12318564281091005,0.9094399059000017,0.3488430311138867,0.4573699485598975,2581]
["O75251","NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [OS=Homo sapiens]",14,3,27,3,213,23.5,9.99,53.49,"cell organization and biogenesis;other metabolic processes;transport","plasma membrane;other membranes;mitochondrion;other cell component","transporter activity;other molecular function","NDUFS7","ENSG00000115286","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",2758.1,2674.2,2675.9,2800.9,2771.1,5203.5,0.7524662428657602,-0.4103012337360373,0.3320715376558361,0.47876834683081915,0.5420077866740746,0.26599447418985767,4478]
["O75306-1","NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [OS=Homo sapiens]",47,17,73,17,463,52.5,7.55,235.08,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion;nucleus","transporter activity;other molecular function","NDUFS2","ENSG00000158864","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",7459.2,7653.7,7888,7397.9,6906.8,7210.3,1.0690634441087614,0.09634747306314458,0.05902447923494915,1.2289678359542022,0.2399387757109251,0.6198995614674392,1798]
["O75312","Zinc finger protein ZPR1 [OS=Homo sapiens]",45,15,37,15,459,50.9,4.73,120.57,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ZPR1","ENSG00000109917","","","",3382,3480.6,3486.2,3652.9,4076.2,4109.1,0.8741869540977513,-0.19398624661840966,0.030114312716217843,1.5212270440643831,0.17195743097096577,0.7645790518282787,1280]
["O75323-1","Protein NipSnap homolog 2 [OS=Homo sapiens]",24,6,16,5,286,33.7,9.36,44.31,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;mitochondrion","","NIPSNAP2","ENSG00000146729","","RHOJ GTPase cycle; RHOH GTPase cycle","",1399,1380.8,1489.7,1410.5,1400.6,1710.6,0.9442245173275539,-0.0827981510604113,0.47658009288530906,0.32186410242310026,0.630922640626467,0.20002388767926552,5521]
["O75330-1","Hyaluronan mediated motility receptor [OS=Homo sapiens]",36,25,38,24,724,84,5.83,108.57,"","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","HMMR","ENSG00000072571","ECM-receptor interaction","AURKA Activation by TPX2; Hyaluronan uptake and degradation","",3871.4,3968.8,4069.2,3954.1,4134.7,4218.1,0.9677010457548206,-0.047366673855844185,0.24207270939526276,0.6160541689519468,0.47206761818836057,0.3259957892837144,3748]
["O75335-1","Isoform 1 of Liprin-alpha-4 [OS=Homo sapiens]",1,1,1,1,701,78,7.28,2.27,"","","","PPFIA4","","","","",174.5,210.6,212.7,176.2,171,354.6,0.8518096323738957,-0.2313970507240721,0.6037069533683275,0.21917382200621824,0.7233596921588697,0.1406456951330123,6100]
["O75340","programmed cell death protein 6 [OS=Homo sapiens]",40,6,30,6,191,21.9,5.4,63.06,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PDCD6","ENSG00000249915","","","Epithelial to mesenchymal transition in colorectal cancer",4072.4,4334.9,4947.4,4434.6,4718.8,5267,0.9260977504091426,-0.11076361567004778,0.37507313572134926,0.42588404069008734,0.5682855615645401,0.2454333779382093,4824]
["O75347","Tubulin-specific chaperone A [OS=Homo sapiens]",34,5,6,5,108,12.8,5.29,13.87,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","TBCA","ENSG00000171530","","Post-chaperonin tubulin folding pathway","VEGFA-VEGFR2 signaling pathway",684.5,964.5,824.1,662.4,642.2,1172.1,0.9985464529414141,-2.0985506739537815E-3,0.9952949363263343,0.002048205446446847,0.9976152893046046,1.0369035454125808E-3,7292]
["O75348","V-type proton ATPase subunit G 1 [OS=Homo sapiens]",7,1,1,1,118,13.7,8.79,1.8,"transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle","transporter activity;other molecular function","ATP6V1G1","ENSG00000136888","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis","Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Osteoclast signaling; Proximal tubule transport",170.4,210,170.4,155.7,174,213.7,1.013617960986382,0.01951399391298919,0.9146505423018501,0.03874480379033008,0.9465072651400569,0.023876048157524483,7063]
["O75351","Vacuolar protein sorting-associated protein 4B [OS=Homo sapiens]",58,20,82,16,444,49.3,7.23,209.91,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","VPS4B","ENSG00000119541","Endocytosis; Necroptosis","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)","",8648.5,8682.1,8867,9435,9482.8,7210.3,1.002659971448364,3.8324327932383177E-3,0.9769219603845919,0.010140127712150756,0.9860962033491206,0.006080713308743444,7241]
["O75352","Mannose-P-dolichol utilization defect 1 protein [OS=Homo sapiens]",10,2,24,2,247,26.6,8.94,56.6,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","","MPDU1","ENSG00000129255","","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective MPDU1 causes CDG-1f","",1624.6,1708.9,1719.5,1346.7,1400.8,1769.4,{"$f":"AVERAGE(S578:U578)/AVERAGE(V578:X578)","v":1.1186875954747726},{"$f":"LOG(Y578,2)","v":0.1618072057644692},{"$f":"TTEST(V578:X578,S578:U578,2,2)","v":0.25960579911457643},0.5856856104258645,{"$f":"AA578*7309/AE578","v":0.4871524481972886},0.31233511055047486,3895]
["O75354-1","Ectonucleoside triphosphate diphosphohydrolase 6 [OS=Homo sapiens]",2,1,2,1,484,53.2,9.26,6.59,"other metabolic processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","ENTPD6","ENSG00000197586","Purine metabolism; Pyrimidine metabolism; Metabolic pathways","Phosphate bond hydrolysis by NTPDase proteins","",83.6,96.6,85.2,107.4,101.6,173.9,0.6931313658918777,-0.5287992894799675,0.17165151923628372,{"$f":"-LOG10(AA579)","v":0.7653523484105883},0.4040582782924308,{"$f":"-LOG10(AC579)","v":0.3935559910392143},3105]
["O75362","zinc finger protein 217 [OS=Homo sapiens]",5,5,5,4,1048,115.2,8.48,14.96,"other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","ZNF217","ENSG00000171940","","Estrogen-dependent gene expression","",218.1,237.1,252,679.9,793.7,323,0.39363241678726485,-1.3450790591379191,0.06297532004445415,1.2008296167129424,0.2475990393786527,0.606251044600868,1859]
["O75367-1","Core histone macro-H2A.1 [OS=Homo sapiens]",48,16,177,16,372,39.6,9.79,596.35,"cell organization and biogenesis;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","H2afy; H2AFY; LOC100466888; LOC101338325; LOC101381952; LOC101564704; LOC102987354; LOC103079324; LOC103663804; LOC106989149; LOC109250833; LOC110591142; LOC111141291; LOC111182462; LOC112404331; LOC112815157; LOC112861289; LOC112917035; LOC113261754; LOC113928700; LOC115516119; LOC116529369; MACROH2A1","ENSAMEG00000017887; ENSCAFG00000001076; ENSCANG00000022762; ENSCJAG00000005818; ENSFCAG00000013924; ENSG00000113648; ENSGGOG00000001707; ENSLCNG00005003680; ENSMLEG00000037795; ENSMNEG00000031666; ENSMPUG00000010011; ENSPCOG00000013464; ENSPCTG00005011747; ENSPPAG00000029258; ENSPTRG00000017256; ENSRBIG00000034425; ENSRROG00000045755; ENSSBOG00000034640; ENSSSUG00005001976; ENSVVUG00000017487","Necroptosis; Neutrophil extracellular trap formation; Alcoholism; Systemic lupus erythematosus","","H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma",28246,28306,28627.3,24213.7,25486.6,17375.4,1.2698980405720701,0.3447126684415105,0.07489008020122573,1.1255757043189445,0.27151368858668595,0.5662082702084591,2016]
["O75368","SH3 domain-binding glutamic acid-rich-like protein [OS=Homo sapiens]",29,5,14,5,114,12.8,5.25,36.43,"","nucleus;other cell component","other molecular function","SH3BGRL","ENSG00000131171","","","",2654.3,2664,2534.5,2685.8,2709.4,3673.7,0.8659043544421041,-0.20772041750192471,0.2842377578646308,0.5463182313238899,0.5094393752409481,0.2929074908820382,4078]
["O75369-1","Filamin-B [OS=Homo sapiens]",14,31,65,20,2602,278,5.73,163.33,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","FLNB","ENSG00000136068","MAPK signaling pathway; Focal adhesion; Salmonella infection; Proteoglycans in cancer","ISG15 antiviral mechanism","Focal adhesion; MAPK signaling pathway; VEGFA-VEGFR2 signaling pathway; Ebola virus pathway in host",1852.3,1838.8,1787.1,1703.7,1659.4,6930.7,0.5321844216907264,-0.9100018150392098,0.4108787426008383,0.38628632700283067,0.5882688990537761,0.23042411154178677,5105]
["O75376-1","Nuclear receptor corepressor 1 [OS=Homo sapiens]",8,21,29,21,2440,270,7.11,79.66,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","NCOR1","ENSG00000141027","Endocrine resistance; Thyroid hormone signaling pathway; Transcriptional misregulation in cancer","HDACs deacetylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Transcriptional activation of mitochondrial biogenesis; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Nuclear Receptor transcription pathway; Cytoprotection by HMOX1; Nuclear signaling by ERBB4; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NR1D1 (REV-ERBA) represses gene expression; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis","Androgen receptor signaling pathway; Adipogenesis; Ovarian infertility; MECP2 and associated Rett syndrome; Pathways affected in adenoid cystic carcinoma; Rett syndrome causing genes; 22q11.2 copy number variation syndrome; Notch signaling pathway (Netpath)",3321.4,3302.5,3251.8,3943.6,3983.5,6022,0.7079811600748436,-0.4982171252969351,0.11911710003442,0.9240258882442938,0.34398533550042504,0.46346007151857505,2531]
["O75379-1","Vesicle-associated membrane protein 4 [OS=Homo sapiens]",32,3,4,3,141,16.4,7.34,8.97,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","VAMP4","ENSCATG00000035773; ENSG00000117533; ENSGGOG00000023200; ENSMFAG00000031870; ENSMLEG00000033096; ENSMMUG00000023203; ENSMNEG00000025169; ENSNLEG00000015204; ENSPANG00000022546; ENSPPAG00000028975; ENSPTRG00000001680; ENSRBIG00000031656; ENSRROG00000036404","SNARE interactions in vesicular transport","Retrograde transport at the Trans-Golgi-Network; Cargo recognition for clathrin-mediated endocytosis","",129.4,142.9,141.1,160.8,199,176,0.7715565509518476,-0.3741561924169317,0.026450554160975363,1.577565224705069,0.16043742768677918,0.7946943097319834,1205]
["O75380","NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [OS=Homo sapiens]",29,3,4,3,124,13.7,8.28,14.58,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity;other molecular function","NDUFS6","ENSG00000145494","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",85.7,92.1,83,120.1,111.9,121.9,0.7369313365357447,-0.4403978921941526,1.6226548012037943E-3,2.7897738608747975,0.04360288213970048,1.3604848030250232,272]
["O75381-1","Peroxisomal membrane protein PEX14 [OS=Homo sapiens]",41,12,27,12,377,41.2,4.94,82.63,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","PEX14","ENSG00000142655; ENSMFAG00000032533; ENSMMUG00000019979; ENSPANG00000017539; ENSPPAG00000038193; ENSPTRG00000000132","Peroxisome","Peroxisomal protein import; E3 ubiquitin ligases ubiquitinate target proteins; Class I peroxisomal membrane protein import","",2906,2822.4,2818.6,3134.3,3222.8,3408.4,0.8752240028672368,-0.192275790551819,9.02348941756256E-3,2.0446254866551192,0.09917696865107481,1.003589170074251,665]
["O75385","Serine/threonine-protein kinase ULK1 [OS=Homo sapiens]",2,2,2,2,1050,112.6,8.79,1.95,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","ULK1","ENSG00000177169","Mitophagy; Autophagy; mTOR signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration","RAB GEFs exchange GTP for GDP on RABs; Macroautophagy; TBC/RABGAPs; Receptor Mediated Mitophagy","Target of rapamycin (TOR) signaling; Alzheimer's disease and miRNA effects; Nanoparticle triggered autophagic cell death; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; 7q11.23 copy number variation syndrome; p53 transcriptional gene network; Malignant pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; Senescence and autophagy in cancer",233.8,262.4,304.2,242.8,233.8,384.4,0.929616724738676,-0.10529207037846516,0.7218907836243711,0.14152850278650625,0.81049151113833,0.09125152947072526,6510]
["O75386","Tubby-related protein 3 [OS=Homo sapiens]",2,1,2,1,442,49.6,7.74,4.86,"developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","TULP3","ENSG00000078246","","Hedgehog 'off' state","H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Genes related to primary cilium development (based on CRISPR)",255.1,261.7,267.2,268.5,277.5,169.8,1.0952780106174909,0.1312971105861863,0.5478656304590859,0.2613259435334428,0.6826372132672108,0.16581004029400315,5866]
["O75390","citrate synthase, mitochondrial [OS=Homo sapiens]",41,17,151,17,466,51.7,8.32,428.26,"other metabolic processes","mitochondrion","other molecular function","CS","ENSG00000062485","Citrate cycle (TCA cycle); Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids","Citric acid cycle (TCA cycle); Mitochondrial protein import","TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Fluoroacetic acid toxicity; TCA cycle (aka Krebs or citric acid cycle)",21580.5,20287.1,20432.1,19051.1,18924.2,21812.9,1.0420066166902497,0.059364438687344846,0.46090791806119696,0.33638583094957974,0.6186916387712192,0.20852575315740052,5445]
["O75396","Vesicle-trafficking protein SEC22b [OS=Homo sapiens]",38,7,51,7,215,24.6,6.92,195.73,"","","","","","","","",4760.8,4723.8,4720.8,4298,4549.9,4692.3,1.0491277824552074,0.06919040707353771,0.12850915506288502,0.8910659318528181,0.35390859621500625,0.4511088884972619,2654]
["O75398","Deformed epidermal autoregulatory factor 1 homolog [OS=Homo sapiens]",1,1,1,1,565,59.3,5.34,2.35,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;nucleus;other cell component","nucleic acid binding activity;other molecular function","DEAF1","ENSG00000177030","","","Sudden infant death syndrome (SIDS) susceptibility pathways",63.8,57.9,72.4,75.4,76.4,45.1,0.9857795835449467,-0.020662993187889986,0.9370299363545658,0.02824653399385238,0.9627146197379142,0.016502432959640937,7114]
["O75400","pre-mRNA-processing factor 40 homolog A [OS=Homo sapiens]",30,24,56,1,957,108.7,7.56,145.1,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","","PRPF40A","ENSG00000196504","Spliceosome","mRNA Splicing - Major Pathway","mRNA processing",104.3,108,90.8,106.6,107.9,152,0.827012278308322,-0.27401934623684515,0.25229138222321856,0.5980975838733193,0.482090905273073,0.31687106147898286,3825]
["O75400-3","Isoform 3 of Pre-mRNA-processing factor 40 homolog A [OS=Homo sapiens]",29,24,60,1,939,106.8,7.43,150.08,"","","","PRPF40A","","","","",7935.2,8064.2,7762.5,8218.2,7747.9,4604.7,1.1551276566783986,0.20805229707848608,0.4027160636568448,0.3950010467809778,0.5829771656303979,0.2343484555924911,5049]
["O75410-1","Transforming acidic coiled-coil-containing protein 1 [OS=Homo sapiens]",52,30,97,27,805,87.7,4.88,317.53,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","TACC1","ENSG00000147526","","","",9193.9,9245.6,9153.6,9714.8,10183.4,9163,0.9494824714739928,-0.0747867280575804,0.17372267799481625,0.7601434844594349,0.40579707685014765,0.3916910857216553,3129]
["O75414","Nucleoside diphosphate kinase 6 [OS=Homo sapiens]",17,3,7,3,186,21.1,8.32,21.18,"other metabolic processes;other biological processes","mitochondrion","kinase activity;other molecular function","NME6","ENSG00000172113","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors","","Pyrimidine metabolism",544.5,547.9,547.5,571.2,530.7,2026,0.5242814667988106,-0.9315865469923318,0.3702706424326328,0.4314807203970678,0.5659364545253268,0.24723233029285085,4782]
["O75419","Cell division control protein 45 homolog [OS=Homo sapiens]",3,2,2,2,566,65.5,5.53,4.77,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","CDC45","ENSG00000093009","Cell cycle","Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA; G1/S-Specific Transcription","Cell cycle; Retinoblastoma gene in cancer; G1 to S cell cycle control; 22q11.2 copy number variation syndrome; DNA replication",174.8,178,188,218.6,205.9,347.2,0.7007904626150058,-0.5129449541258785,0.1645916190922943,0.7835922825784034,0.3959842475133572,0.40232209022119797,3038]
["O75420","GRB10-interacting GYF protein 1 [OS=Homo sapiens]",8,6,8,6,1035,114.5,5.39,22.65,"signal transduction","cytosol;other cell component","","GIGYF1","ENSG00000146830","","","",353.9,317.3,323.1,366.4,385.5,676.8,0.6959473647371737,-0.5229498972963594,0.2252491959641009,0.6473367505774341,0.45605162695335555,0.3409859905991191,3610]
["O75427","Leucine-rich repeat and calponin homology domain-containing protein 4 [OS=Homo sapiens]",29,13,29,13,683,73.4,8.22,97.56,"developmental processes","nucleus","","LRCH4","ENSG00000077454","","","",1596.9,1635.6,1667.6,1491.8,1598.6,1369.7,1.0986524965807944,0.13573513447796293,0.10145212384724513,0.9937388568072328,0.3155376907231977,0.5009487571949961,2350]
["O75431","Metaxin-2 [OS=Homo sapiens]",39,7,29,7,263,29.7,6.29,115.23,"cell organization and biogenesis;transport","other membranes;mitochondrion;nucleus;other cell component","","MTX2","ENSG00000128654","","Mitochondrial protein import; Cristae formation","",1578.7,1606.1,1593,1666.1,1478.8,2193.3,0.8950207935259078,-0.16000689478059651,0.43207235098174074,0.3644435240156659,0.6004975876260777,0.2214887329451503,5259]
["O75436-1","Vacuolar protein sorting-associated protein 26A [OS=Homo sapiens]",51,14,42,12,327,38.1,6.57,115.45,"transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","VPS26A","ENSANAG00000022406; ENSCATG00000037809; ENSCCAG00000021117; ENSCJAG00000012907; ENSCSAG00000007798; ENSG00000122958; ENSMFAG00000042937; ENSMMUG00000004101; ENSMNEG00000039163; ENSNLEG00000011548; ENSPANG00000022152; ENSPPAG00000041182; ENSPPYG00000002386; ENSPTRG00000002567; ENSRBIG00000023684; ENSRROG00000006745; ENSSBOG00000030031","Endocytosis","WNT ligand biogenesis and trafficking","",3939.2,4090.7,3966.8,3823.6,3271.8,3597.8,1.1218998990012343,0.1659439578923333,0.05973998105804845,1.223734919435043,0.24177160661864683,0.6165947035285572,1806]
["O75438","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [OS=Homo sapiens]",19,1,3,1,58,7,8.92,7.18,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB1","ENSG00000183648","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",251.2,178,253.5,266.8,521.1,816.7,0.4254642901657734,-1.2328900453796405,0.12861230441391927,0.890717480218634,0.353792748574082,0.4512510727449386,2657]
["O75439","mitochondrial-processing peptidase subunit beta [OS=Homo sapiens]",42,17,69,16,489,54.3,6.83,218.05,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport","other membranes;mitochondrion","other molecular function","PMPCB","ENSG00000105819","","Mitochondrial protein import; Processing of SMDT1","",6644.3,6963.7,6897.6,6338.3,5830.4,6872,1.0769351967102048,0.10693144004216626,0.19726268029219937,0.7049550702278983,0.43219212537640445,0.36432315030962636,3336]
["O75448","Mediator of RNA polymerase II transcription subunit 24 [OS=Homo sapiens]",14,10,14,10,989,110.2,6.95,41.37,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","MED24","ENSG00000008838","Thyroid hormone signaling pathway","Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","",947.3,967,941.5,891.1,956.1,840,1.062741887466508,0.08779124607987827,0.17835147538612486,0.7487232936740856,0.412261522326751,0.3848271973863029,3162]
["O75449-1","Katanin p60 ATPase-containing subunit A1 [OS=Homo sapiens]",15,8,11,7,491,55.9,6.9,16.05,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KATNA1","ENSG00000186625","","","",1218.8,1408.3,1423.4,1414.4,1283.5,1140.5,1.055257398916215,0.07759494475858195,0.5298116388195553,0.27587850542046355,0.6700801640650855,0.17387323800287371,5779]
["O75460","Serine/threonine-protein kinase/endoribonuclease IRE1 [OS=Homo sapiens]",22,15,31,15,977,109.7,6.42,111.1,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","ERN1","ENSG00000178607","Autophagy; Protein processing in endoplasmic reticulum; Apoptosis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Lipid and atherosclerosis","IRE1alpha activates chaperones","Alzheimer's disease and miRNA effects; Corticotropin-releasing hormone signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling pathway; Nonalcoholic fatty liver disease; Unfolded protein response; Alzheimer's disease",2205.5,2208.9,2211.5,2940.8,3198.4,4318.1,0.6336147954060799,-0.6583220710074611,0.03912750240508601,1.4075178731907478,0.19388672208730418,0.7124519316209565,1475]
["O75475-1","PC4 and SFRS1-interacting protein [OS=Homo sapiens]",51,28,82,27,530,60.1,9.13,247.61,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PSIP1","ENSG00000164985; ENSGGOG00000016152; ENSPTRG00000020786","","Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection","MECP2 and associated Rett syndrome",11726.9,11405.7,10829.8,11971.4,12573.7,10714.8,0.9632018241685314,-0.05408997052604102,0.5156452650309823,0.2876489658525442,0.6594665340527471,0.18080723869987173,5715]
["O75477","erlin-1 [OS=Homo sapiens]",27,10,23,7,346,38.9,7.87,65.26,"","","","","","","","",1804.8,1798.3,1798.9,1796.5,1707.4,2433.8,0.9097798810987419,-0.13641056370910928,0.4786288388441448,0.3200011373699951,0.631918024406043,0.19933925693472354,5536]
["O75487","Glypican-4 [OS=Homo sapiens]",10,4,7,4,556,62.4,6.68,26.89,"cell adhesion;cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes","extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","GPC4","ENSG00000076716","Wnt signaling pathway","A tetrasaccharide linker sequence is required for GAG synthesis; HS-GAG biosynthesis; HS-GAG degradation; Defective B4GALT7 causes EDS, progeroid type; Defective B3GAT3 causes JDSSDHD; Defective EXT2 causes exostoses 2; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Defective B3GALT6 causes EDSP2 and SEMDJL1; Retinoid metabolism and transport","Wnt signaling",676.6,726.1,718.6,775.3,921.1,793.6,0.8519277108433735,-0.2311970771503258,0.06393562903724954,1.1942570576153135,0.24949573552229412,0.6029368731065778,1873]
["O75489","NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [OS=Homo sapiens]",63,16,72,16,264,30.2,7.5,211.44,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion;nucleus","transporter activity;other molecular function","NDUFS3","ENSG00000213619; ENSG00000285387","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","RHOG GTPase cycle; Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",8135.1,8007.6,8172.3,8658.4,8690.6,6648.9,1.013213656194917,0.018938427082033676,0.8835109463898052,0.053788065368038714,0.9234350789594002,0.034593631724304914,6993]
["O75494-1","Serine/arginine-rich splicing factor 10 [OS=Homo sapiens]",30,10,43,10,262,31.3,11.27,118.09,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","Srsf10; SRSF10","ENSCATG00000031598; ENSCCAG00000022497; ENSCPOG00000034102; ENSG00000188529; ENSGGOG00000000392; ENSMLEG00000016013; ENSMNEG00000041500; ENSMUSG00000028676; ENSNLEG00000027520; ENSPANG00000021680; ENSPCOG00000022379; ENSPCTG00005007467; ENSPPAG00000032557; ENSPPYG00000001726; ENSPTRG00000044753; ENSRBIG00000028456; ENSRFEG00010001865; ENSRROG00000043248; ENSSBOG00000019550; ENSSSCG00070027414; ENSSTOG00000000956; ENSTSYG00000009439","Spliceosome","mRNA Splicing - Major Pathway; mRNA Splicing - Major Pathway","mRNA processing; mRNA processing; mRNA Processing",6931.9,6735.5,6486,6696.7,7399.6,7740.8,0.9228972711578003,-0.11575802625727766,0.16754934844167818,0.775857256690148,0.3995491640327001,0.398429773660609,3065]
["O75503","Ceroid-lipofuscinosis neuronal protein 5 [OS=Homo sapiens]",13,3,4,3,358,41.5,7.4,11.35,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CLN5","ENSG00000102805","Lysosome","","",116.4,131,117.5,90.4,99.1,128.5,1.1474842767295597,0.19847438541276363,0.27744465987411254,0.5568236298677457,0.5036867906159683,0.29783943853640843,4026]
["O75521","Enoyl-CoA delta isomerase 2, mitochondrial [OS=Homo sapiens]",48,13,45,13,394,43.6,9,154.73,"other metabolic processes","cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","ECI2","ENSG00000198721","Fatty acid degradation; Peroxisome","","",3841.9,3788.2,3804.8,3618.1,3693.1,3085.9,1.0998162949283936,0.13726256690547495,0.14560596053065805,0.8368208463650885,0.3753911694950898,0.42551594771004086,2835]
["O75525-1","KH domain-containing, RNA-binding, signal transduction-associated protein 3 [OS=Homo sapiens]",9,4,17,2,346,38.8,7.61,34.39,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KHDRBS3","ENSCCAG00000031191; ENSG00000131773; ENSGGOG00000000940; ENSRBIG00000036854; ENSRROG00000044792","","PTK6 Regulates Proteins Involved in RNA Processing","",103,92.2,103.4,126.9,130.9,228.7,0.6137718396711204,-0.7042256395339324,0.13478303717878748,0.870364761533641,0.36072106142063626,0.44282849978940136,2731]
["O75530","Polycomb protein EED [OS=Homo sapiens]",20,7,11,7,441,50.2,7.03,34.57,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","EED","ENSG00000074266","","Transcriptional Regulation by E2F6; HCMV Early Events; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; PKMTs methylate histone lysines; PRC2 methylates histones and DNA; Defective pyroptosis","Histone modifications; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Malignant pleural mesothelioma",1081.3,1153.7,1144.8,1224,1058,1029.6,1.0205942746708543,0.029409453628023278,0.7432962548572386,0.128838055410333,0.8256462502661941,0.08320598714031549,6580]
["O75531","Barrier-to-autointegration factor [OS=Homo sapiens]",30,3,4,3,89,10.1,6.09,5.01,"cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","BANF1","ENSG00000175334","","Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Nuclear Envelope Breakdown; Initiation of Nuclear Envelope (NE) Reformation","Envelope proteins and their potential roles in EDMD physiopathology; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy",227.9,265.5,234.9,227.2,247.3,164.6,1.1395712721013924,0.18849115776838116,0.3396271325705894,0.4689976215641699,0.5466493529967932,0.2622911615811636,4541]
["O75533-1","splicing factor 3B subunit 1 [OS=Homo sapiens]",49,53,229,53,1304,145.7,7.09,699.58,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","LOC101357717; LOC111145177; Sf3b1; SF3B1","ENSANAG00000021577; ENSCANG00000029415; ENSCATG00000035735; ENSCCAG00000020506; ENSCGRG00001016990; ENSCGRG00015028775; ENSCJAG00000003902; ENSCSAG00000011505; ENSDLEG00000016863; ENSFCAG00000005038; ENSG00000115524; ENSLAFG00000001956; ENSLCNG00005009987; ENSMMNG00015005194; ENSMMUG00000022430; ENSMNEG00000042333; ENSMPUG00000007799; ENSMUSG00000025982; ENSNLEG00000006861; ENSPANG00000013417; ENSPCTG00005000567; ENSPPAG00000035007; ENSRNOG00000013516; ENSRROG00000031308; ENSSBOG00000020080; ENSSSCG00000016075; ENSSSCG00070023758; ENSSSUG00005005995; ENSSTOG00000011034; ENSUMAG00000020945","Spliceosome","B-WICH complex positively regulates rRNA expression; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; mRNA Splicing - Major Pathway; B-WICH complex positively regulates rRNA expression; mRNA Splicing - Minor Pathway; mRNA Splicing - Major Pathway; B-WICH complex positively regulates rRNA expression; mRNA Splicing - Minor Pathway","mRNA processing; mRNA processing; mRNA processing",26109.2,26224.2,25894.1,30282.9,29921.9,30516.4,0.8622846699558646,-0.21376386346816573,3.0290813928255083E-5,4.5186890568156866,0.008515213807754477,2.0698044429025315,26]
["O75534","cold shock domain-containing protein E1 [OS=Homo sapiens]",39,32,122,32,798,88.8,6.25,346.46,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","nucleic acid binding activity","CSDE1","ENSG00000009307","","","",17683.4,17990,18057.9,22128.8,21274.5,18451.9,0.8686626185025673,-0.20313214008434816,0.07241106481024111,1.1401950661389364,0.26622357781592165,0.574753484316258,1988]
["O75554","WW domain-binding protein 4 [OS=Homo sapiens]",5,2,2,2,376,42.5,5.57,5.48,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","WBP4","ENSG00000120688","","mRNA Splicing - Major Pathway","",296.8,264.7,269.8,347.1,344.6,448.2,0.7292744977629615,-0.4554661499894648,0.0443957609352619,1.3526584958834458,0.20880863363952976,0.6802515484643682,1554]
["O75558","syntaxin-11 [OS=Homo sapiens]",5,1,4,1,287,33.2,6.55,17.41,"cell-cell signaling;cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","STX11","ENSG00000135604","SNARE interactions in vesicular transport","","",212.8,232.8,216.1,201.2,219,241.1,1.0006048691970364,8.7237798025648148E-4,0.9923641788881957,3.3289207319181302E-3,0.9960436395899235,1.7216334458701286E-3,7282]
["O75569-1","Interferon-inducible double-stranded RNA-dependent protein kinase activator A [OS=Homo sapiens]",29,8,30,8,313,34.4,8.41,86.74,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;kinase activity;other molecular function","PRKRA","ENSCATG00000032736; ENSG00000180228; ENSMNEG00000031681; ENSPANG00000001046; ENSPTRG00000012688","","MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis","VEGFA-VEGFR2 signaling pathway; Ebola virus pathway in host",3703.2,3619.8,3656.1,3353.5,3310.7,3951.7,1.0342128316958525,0.04853310986541282,0.5922844469076988,0.22746967156444003,0.7145934338805497,0.145940978677304,6058]
["O75570","Peptide chain release factor 1, mitochondrial [OS=Homo sapiens]",6,2,3,2,445,52.3,8.5,7.44,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","mitochondrion","nucleic acid binding activity","MTRF1","ENSG00000120662","","","",167.7,197,206.5,159,187.2,79.5,1.3417899929527837,0.4241588892473922,0.23018791397957236,0.6379174827469484,0.4613225838433492,0.3359952841767567,3647]
["O75582-1","Ribosomal protein S6 kinase alpha-5 [OS=Homo sapiens]",3,2,2,2,802,89.8,7.11,4.81,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","kinase activity;other molecular function","RPS6KA5","ENSG00000100784; ENSGGOG00000004254; ENSPPAG00000038077; ENSPTRG00000006631","MAPK signaling pathway; Adrenergic signaling in cardiomyocytes; TNF signaling pathway; Circadian entrainment; Neurotrophin signaling pathway; Shigellosis; Pathways in cancer; MicroRNAs in cancer; Bladder cancer","Recycling pathway of L1; NCAM signaling for neurite out-growth; ERK/MAPK targets; CREB phosphorylation; CD209 (DC-SIGN) signaling","Brain-derived neurotrophic factor (BDNF) signaling pathway; Interleukin-1 (IL-1) structural pathway; Bladder cancer; MAPK signaling pathway; ERK pathway in Huntington's disease; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; p38 MAPK signaling pathway; EGF/EGFR signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Insulin signaling; Malignant pleural mesothelioma; Interferon type I signaling pathways; Serotonin receptor 4/6/7 and NR3C signaling; EGFR1 signaling pathway; MAPK signaling pathway; p38 MAPK signaling pathway",93.6,101.7,100,96.9,107.3,78.4,1.0449398443029017,0.06341989080001491,0.6557346948416228,0.18327183725823207,0.7607563308884795,0.11875442482784085,6300]
["O75586","Mediator of RNA polymerase II transcription subunit 6 [OS=Homo sapiens]",13,4,4,4,246,28.4,8.62,8.85,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MED6","ENSG00000133997","","Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","",669.1,661.7,708.1,761.2,780.3,433.3,1.032458983188171,0.04608446839878372,0.8598851915057186,0.06555953017968348,0.9082226683114593,0.04180766275246828,6920]
["O75592-1","E3 ubiquitin-protein ligase MYCBP2 [OS=Homo sapiens]",18,71,138,1,4640,509.8,7.03,376.42,"","","","","","","","",93.7,100.7,104.1,92.7,85.7,60.1,1.251572327044025,0.32374166525929343,0.12602500887367687,0.899543263310254,0.351839873895227,0.4536549436410181,2618]
["O75592-2","Isoform 2 of E3 ubiquitin-protein ligase MYCBP2 [OS=Homo sapiens]",18,71,138,1,4637,509.4,7.03,374.77,"","","","","","","","",14491.7,14189.7,13844.8,14164.2,14023.6,17951.4,0.92169348406561,-0.11764104330029349,0.40666016964056373,0.39076836251653324,0.5859016715755727,0.23217526294996443,5073]
["O75607","Nucleoplasmin-3 [OS=Homo sapiens]",44,5,34,5,178,19.3,4.63,111.29,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","NPM3","ENSG00000107833","","","",2432.1,2411.6,2519.3,2851.6,2587.8,2784.3,0.8953390809489645,-0.15949393456717173,0.028681408671185234,1.5423995223522589,0.1673044022168339,0.7764926314624359,1253]
["O75608","Acyl-protein thioesterase 1 [OS=Homo sapiens]",49,8,37,8,230,24.7,6.77,117.04,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","LYPLA1","ENSG00000120992","Glycerophospholipid metabolism; Choline metabolism in cancer","RAS processing; eNOS activation","",4706.6,4923.8,5119.9,4325.1,4437.5,4005.5,1.155246277833037,0.20820044119415107,0.01989147019327255,1.7013331166629384,0.14184073721232102,0.8481990201707386,1025]
["O75616-1","GTPase Era, mitochondrial [OS=Homo sapiens]",24,7,15,7,437,48.3,8.84,51.11,"cell organization and biogenesis","other membranes;cytosol;mitochondrion","translation activity;nucleic acid binding activity;other molecular function","ERAL1","ENSG00000132591","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Integrated breast cancer pathway",1223.4,1264.1,1357.7,1177.6,1257.3,1558,0.963009341581307,-0.05437830202355084,0.7082107758125263,0.14983746950064905,0.8005432354490806,0.09661520789221337,6466]
["O75626-1","PR domain zinc finger protein 1 [OS=Homo sapiens]",5,4,9,3,825,91.7,8.48,18.45,"cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","PRDM1","ENSG00000057657","","STAT3 nuclear events downstream of ALK signaling; Regulation of TP53 Expression","Nucleotide-binding oligomerization domain (NOD) pathway; Vitamin D receptor pathway; IL-6 signaling pathway; Overview of leukocyte-intrinsic Hippo pathway functions",248,261.4,246.9,561.4,636.4,576.9,0.42615653349861954,-1.2305446441973515,1.297207787211651E-4,3.886990452896923,0.013544702452471366,1.868230531027207,70]
["O75643-1","U5 small nuclear ribonucleoprotein 200 kDa helicase [OS=Homo sapiens]",42,80,293,79,2136,244.4,6.06,888.7,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","SNRNP200","ENSCATG00000015790; ENSG00000144028; ENSGGOG00000005174; ENSMLEG00000019083; ENSPPAG00000041559; ENSPPYG00000012068; ENSPTRG00000012230; ENSRBIG00000044690; ENSRROG00000037952","Spliceosome","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","",33978.2,34549.7,34555.3,35500,35005.1,29160.1,1.0342948190541932,0.04864747517154324,0.6071084166605792,0.2167337462344341,0.7258883391742473,0.13913018014024134,6113]
["O75648-1","Mitochondrial tRNA-specific 2-thiouridylase 1 [OS=Homo sapiens]",33,12,22,12,421,47.7,8.03,61.55,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","nucleic acid binding activity;other molecular function","TRMU","ENSG00000100416","","tRNA modification in the mitochondrion","",1746.4,1818.6,1777.5,1629.2,1459.8,1880,1.0751660293821694,0.10455946099706344,0.37160349865034414,0.42992020577262147,0.5663156738188835,0.2469414183154596,4796]
["O75663","TIP41-like protein [OS=Homo sapiens]",33,9,38,9,272,31.4,5.91,107.7,"stress response;signal transduction;other biological processes","cytosol","","TIPRL","ENSG00000143155","","","Ciliary landscape",5342.9,5313.8,5209.9,5484.6,5165.1,4674,1.0354287802554212,0.050228324291501314,0.4913870320904381,0.30857630891796045,0.6420357199765842,0.19244080906949598,5594]
["O75665","Oral-facial-digital syndrome 1 protein [OS=Homo sapiens]",4,4,4,4,1012,116.6,6.1,14.19,"cell organization and biogenesis;transport;developmental processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","OFD1","ENSG00000046651","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Hedgehog 'off' state","Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies",285.8,310.8,314.6,387.9,309.6,310.8,0.9036992958444908,-0.146085296321046,0.3034282095316679,0.5179440455847941,0.5233026860469467,0.28124703607559703,4238]
["O75674","TOM1-like protein 1 [OS=Homo sapiens]",5,1,2,1,476,53,5.24,10.18,"protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","TOM1L1","ENSG00000141198","","","",47.3,40.1,40.3,43.3,65.3,97.7,0.619001454192923,-0.6919852961837608,0.17635007127194174,0.7536243604761924,0.4095782239995622,0.38766314150543973,3147]
["O75676","Ribosomal protein S6 kinase alpha-4 [OS=Homo sapiens]",9,7,8,7,772,85.6,8.28,21.95,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","RPS6KA4","ENSG00000162302","MAPK signaling pathway; TNF signaling pathway","Recycling pathway of L1","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Translation inhibitors in chronically activated PDGFRA cells; Insulin signaling; Interferon type I signaling pathways",667.6,687.4,735,628.6,711.3,819,0.9680855991477141,-0.046793477133319626,0.7152730893151064,0.14552811408852578,0.8051641783157419,0.09411555507730879,6493]
["O75683","Surfeit locus protein 6 [OS=Homo sapiens]",17,3,6,3,361,41.4,10.64,16.61,"other biological processes","nucleus;other cell component","nucleic acid binding activity","SURF6","ENSG00000148296; ENSG00000281309","","","",54.3,51.1,36.9,107.4,111.5,148,0.38784409920959395,-1.3664512427220603,5.8473350983035115E-3,2.2330420169590246,0.0795869129115463,1.099158340774607,537]
["O75688","Protein phosphatase 1B [OS=Homo sapiens]",30,12,32,1,479,52.6,5.05,85.91,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;nucleus","other molecular function","PPM1B","ENSG00000138032","MAPK signaling pathway","ISG15 antiviral mechanism; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants","MAPK signaling pathway",2756.6,2803.7,2788.3,2757.5,2841.6,2556.3,1.0236898251465285,0.033778649410408756,0.49449405169104454,0.30583892819884106,0.6443674494223293,0.19086640632438479,5609]
["O75688-2","Isoform Beta-2 of Protein phosphatase 1B [OS=Homo sapiens]",36,12,32,1,387,42.7,5.2,78.89,"","","","PPM1B","","","","",209.1,175.2,177.9,193.8,197.4,280.3,0.8372300819061801,-0.2563039459344619,0.2951567224048546,0.529947320963585,0.5169663273561184,0.28653774379132085,4173]
["O75691","Small subunit processome component 20 homolog [OS=Homo sapiens]",11,23,31,23,2785,318.2,7.39,92.85,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;nucleus;other cell component","","UTP20","ENSG00000120800","","rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol","",2766.1,2733.5,2726.1,5034.3,5337.5,4439.7,0.5553590115788407,-0.8485073922968249,1.1420233058144318E-3,2.9423250331450523,0.03677113807135542,1.434492928454202,227]
["O75694","nuclear pore complex protein nup155 [OS=Homo sapiens]",25,26,67,26,1391,155.1,6.16,198.87,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus","other molecular function","NUP155","ENSG00000113569","Nucleocytoplasmic transport; Amyotrophic lateral sclerosis","HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation","",6109.6,6085.7,6081.9,5660,5298.9,4918.9,1.151116653440653,0.20303404269044953,0.020208548361727852,1.694464881988599,0.14284746612753277,0.8451274588625496,1034]
["O75695","Protein XRP2 [OS=Homo sapiens]",31,9,25,9,350,39.6,5.12,60.43,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","RP2","ENSG00000102218","","Trafficking of myristoylated proteins to the cilium","Joubert syndrome; Ciliopathies",2553.6,2534.7,2616.3,2028.4,2125.4,2211,{"$f":"AVERAGE(S642:U642)/AVERAGE(V642:X642)","v":1.2105015082956259},{"$f":"LOG(Y642,2)","v":0.2756048769487982},{"$f":"TTEST(V642:X642,S642:U642,2,2)","v":1.5534027546662945E-3},2.808715929041591,{"$f":"AA642*7309/AE642","v":0.042844606542852624},1.3681038410944257,265]
["O75717","WD repeat and HMG-box DNA-binding protein 1 [OS=Homo sapiens]",16,12,13,12,1129,125.9,5.62,27.54,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response","nucleus;other cell component","nucleic acid binding activity;other molecular function","WDHD1","ENSG00000198554","","","Mesodermal commitment pathway",1140.2,1147.1,1131.5,1235.9,1365.9,1920.1,0.756053871160353,-0.40343906032601384,0.15459127733667916,{"$f":"-LOG10(AA643)","v":0.8108150143725362},0.3872198924104825,{"$f":"-LOG10(AC643)","v":0.41204234004599605},2918]
["O75718","Cartilage-associated protein [OS=Homo sapiens]",17,6,7,6,401,46.5,5.73,22.1,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;ER/Golgi;other cell component","","CRTAP","ENSG00000170275","","Collagen biosynthesis and modifying enzymes","Type I collagen synthesis in the context of osteogenesis imperfecta",399.7,420.8,403.3,425.9,421.3,758.5,0.7621598056922214,-0.3918345686810599,0.31853717868948245,0.49683987084082915,0.5349697240444455,0.2716707956469797,4352]
["O75746","Calcium-binding mitochondrial carrier protein Aralar1 [OS=Homo sapiens]",27,17,28,12,678,74.7,8.38,83.01,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","SLC25A12","ENSG00000115840","","Mitochondrial protein import; Gluconeogenesis; Aspartate and asparagine metabolism","",3803.7,3816.1,3926.8,3441.1,3498,5925.1,0.8975762192751978,-0.15589364174393847,0.6204640356900033,0.2072833866939181,0.7351226514602421,0.1336401950539245,6169]
["O75787","Renin receptor [OS=Homo sapiens]",12,3,6,3,350,39,6.1,20.4,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ATP6AP2","ENSG00000182220","Renin-angiotensin system","Neutrophil degranulation; Metabolism of Angiotensinogen to Angiotensins","ACE inhibitor pathway; Oxidative phosphorylation",228.3,264.5,266.4,217.2,219.8,699.8,0.6678395496129487,-0.5824265622216709,0.4778082934559629,0.3207463163464975,0.6316333544709049,0.1995349444012607,5529]
["O75792","Ribonuclease H2 subunit A [OS=Homo sapiens]",25,7,14,7,299,33.4,5.25,47.15,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RNASEH2A","ENSG00000104889","DNA replication","","",1127.7,1127.7,1118,1261.8,1300.3,1489,0.8327121028856361,-0.2641103022147632,0.03245127302065418,1.488768261729522,0.17833560489320407,0.7487619408126348,1330]
["O75794","Cell division cycle protein 123 homolog [OS=Homo sapiens]",24,6,16,6,336,39.1,4.81,41.87,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","other cell component","","CDC123","ENSG00000151465","","","",821,783.3,782.5,1634.7,1621,1726.7,0.4790462427745665,-1.0617631675241368,1.6881395383651387E-5,4.772591658280652,0.007711632428694249,2.1128536790526034,16]
["O75795","UDP-glucuronosyltransferase 2B17 [OS=Homo sapiens]",11,6,14,6,530,61.1,8.54,31.24,"other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","UGT2B17","ENSG00000197888","Pentose and glucuronate interconversions; Ascorbate and aldarate metabolism; Steroid hormone biosynthesis; Retinol metabolism; Porphyrin and chlorophyll metabolism; Metabolism of xenobiotics by cytochrome P450; Drug metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors; Bile secretion; Chemical carcinogenesis; Chemical carcinogenesis","Glucuronidation","Glucuronidation; Metapathway biotransformation Phase I and II",1059.8,1054.5,1072.6,1013,962.9,3682.9,0.56317593836149,-0.8283423986041109,0.41098261365400107,0.386176550274396,0.5880720288169722,0.23056947698180072,5108]
["O75808-1","Calpain-15 [OS=Homo sapiens]",5,3,3,3,1086,117.2,6.71,12.14,"protein metabolism","other cell component","other molecular function","CAPN15","ENSG00000103326","","Degradation of the extracellular matrix","",123.4,122.9,131.3,138.4,142.6,210.4,0.7684167684167685,-0.38003909300032335,0.18163417355825537,0.7408024377999369,0.4147342001053697,0.38223015006009625,3201]
["O75817","Ribonuclease P protein subunit p20 [OS=Homo sapiens]",11,1,3,1,140,15.6,8.94,12.21,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POP7","ENSG00000172336","Ribosome biogenesis in eukaryotes","tRNA processing in the nucleus","",269.4,254.6,245.7,335.9,323.8,584.1,0.6188293937932142,-0.6923863698642169,0.13688090330328578,0.8636571374650708,0.3638045535431694,0.43913186941136045,2750]
["O75818-1","Ribonuclease P protein subunit p40 [OS=Homo sapiens]",8,2,3,2,363,41.8,6.67,14.23,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RPP40","ENSG00000124787","Ribosome biogenesis in eukaryotes","tRNA processing in the nucleus; Major pathway of rRNA processing in the nucleolus and cytosol","",498.9,441.6,463.3,446.8,487,501,0.9783942012824087,-0.0315122415186934,0.6803307435971275,0.16727990317892424,0.7804955901665994,0.10762954637699272,6371]
["O75820-1","Zinc finger protein 189 [OS=Homo sapiens]",7,3,6,1,626,72.9,8.5,8.26,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF189","ENSG00000136870; ENSGGOG00000003650; ENSPPAG00000034345; ENSPPYG00000019452; ENSPTRG00000021200","Herpes simplex virus 1 infection","Generic Transcription Pathway","",14.7,13.5,3.9,18.5,15.2,19.3,0.6056603773584905,-0.7234190623282584,0.12821749354744658,0.8920527171508726,0.35403916144249603,0.4509486965682479,2647]
["O75821","Eukaryotic translation initiation factor 3 subunit G [OS=Homo sapiens]",57,20,77,20,320,35.6,6.13,246.58,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity","EIF3G","ENSG00000130811","","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell",8788,8662.1,8560.1,10523.9,10441.8,9435.6,0.8555620976734548,-0.2250555239198794,0.014719554145159216,1.832105344565749,0.12351919775771378,0.9082655376894392,871]
["O75822","Eukaryotic translation initiation factor 3 subunit J [OS=Homo sapiens]",32,9,27,9,258,29,4.83,70.19,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3J","ENSG00000104131","","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell",5760.8,5350.1,5304.2,4235.1,2742.7,1239.7,1.9975783389108615,0.9982520823482691,0.03564735221271009,1.4479727228139285,0.1853104532878365,0.7321000816137606,1406]
["O75828","Carbonyl reductase [NADPH] 3 [OS=Homo sapiens]",43,10,31,6,277,30.8,6.18,97.68,"other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","CBR3","ENSG00000159231","Arachidonic acid metabolism; Metabolism of xenobiotics by cytochrome P450; Metabolic pathways","Phase I - Functionalization of compounds","Nuclear receptors meta-pathway; NRF2 pathway",1064.9,1073.9,1156.3,986.2,1054.3,967.3,1.0955183190371702,0.13161360898638252,0.07141228424105482,1.1462270750694779,0.26495044950145674,0.5768353393470976,1970]
["O75832","26S proteasome non-ATPase regulatory subunit 10 [OS=Homo sapiens]",54,9,38,9,226,24.4,6.1,130.27,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","PSMD10","ENSG00000101843","","Degradation of DVL; Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Parkin-ubiquitin proteasomal system pathway",3588.8,3444.6,3880.6,3896.7,3581.6,7583.3,0.7246242099112977,-0.4646950874186934,0.3445273041445013,0.46277635410643764,0.5487361224650599,0.26063644991712404,4589]
["O75843","AP-1 complex subunit gamma-like 2 [OS=Homo sapiens]",5,4,6,4,785,87.1,6.55,14.17,"transport","other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","AP1G2","ENSG00000213983","Lysosome; Human immunodeficiency virus 1 infection","Lysosome Vesicle Biogenesis","",494.1,456.5,458.7,534.2,524.9,860.7,0.734086884050422,-0.44597726918869984,0.20032170663614454,0.6982719884921137,0.43588906037617753,0.3606240304498051,3359]
["O75844","caax prenyl protease 1 homolog [OS=Homo sapiens]",31,14,57,14,475,54.8,7.49,155.37,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZMPSTE24","ENSG00000084073","Terpenoid backbone biosynthesis","","Adipogenesis; Lamin A-processing pathway; Nephrotic syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy",7190.2,7545.4,7702.1,5900.9,6486.7,3979.5,1.3709026033933929,0.45512607761409707,0.058773521810674294,1.2308182848323765,0.2393179225148849,0.6210247758627415,1795]
["O75865-1","Trafficking protein particle complex subunit 6A [OS=Homo sapiens]",6,1,1,1,159,17.6,5.26,2.3,"cell organization and biogenesis;transport;other biological processes","cytosol;ER/Golgi;other cell component","","TRAPPC6A","ENSG00000007255","","RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport","",27.1,26.4,31.5,32.7,26.5,20.4,1.0678391959798996,0.09469441048141544,0.6678498843757621,0.17532114488032707,0.7701664255131658,0.11341541785063582,6338]
["O75874","Isocitrate dehydrogenase [NADP] cytoplasmic [OS=Homo sapiens]",52,22,138,21,414,46.6,7.01,357.16,"other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","IDH1","ENSG00000138413","Citrate cycle (TCA cycle); Glutathione metabolism; Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids; Peroxisome; Central carbon metabolism in cancer","Peroxisomal protein import; Neutrophil degranulation; Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate; NADPH regeneration","Glutathione metabolism; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism",17224.6,17607.1,17792.4,16471.9,16563,15304.6,1.0886355878732712,0.12252110414558189,0.031118987977972228,1.5069745351633546,0.174826043913143,0.7573938698409678,1301]
["O75879","Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial [OS=Homo sapiens]",11,5,11,5,557,61.8,8.63,26.29,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","other molecular function","GATB","ENSG00000059691","Aminoacyl-tRNA biosynthesis; Metabolic pathways","","",772.1,788.9,768,777.3,836.9,765.8,0.9785714285714285,-0.03125093398443979,0.4998664809211403,0.30114598434972817,0.6474435777162173,0.18879807273579655,5643]
["O75880","Protein SCO1 homolog, mitochondrial [OS=Homo sapiens]",5,2,5,2,301,33.8,8.88,12.22,"cell organization and biogenesis;other biological processes","other membranes;cytoskeleton;mitochondrion","other molecular function","SCO1","ENSG00000133028","","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis",931.9,937.7,947.1,968.9,1023.5,703.3,1.0448863004043476,0.06334596358159406,0.7045598915967499,0.15208208348517763,0.7982682138708178,0.09785116349525434,6451]
["O75882-1","Attractin [OS=Homo sapiens]",1,3,3,3,1429,158.4,7.31,6.16,"cell adhesion;stress response;developmental processes;other biological processes","extracellular matrix;plasma membrane;other membranes;other cell component","other molecular function","ATRN","ENSG00000088812","","","",484.7,442.3,429.6,502.7,528.6,399.5,0.9481409001956946,-0.07682662552254038,0.5943686798143575,0.22594408373969704,0.7162804090293716,0.14491692705831585,6065]
["O75884-1","Putative hydrolase RBBP9 [OS=Homo sapiens]",16,3,3,3,186,21,6.2,8.55,"other biological processes","nucleus","other molecular function","RBBP9","ENSG00000089050; ENSPPAG00000038694; ENSPTRG00000013289","","","",538.8,424.1,456.2,629.3,542.8,1616.2,0.5089481045798514,-0.9744095369797603,0.2575658887645494,0.5891116541315788,0.4858191176722817,0.31352539908993493,3875]
["O75886","Signal transducing adapter molecule 2 [OS=Homo sapiens]",17,8,15,7,525,58.1,5.07,44.99,"cell organization and biogenesis;other metabolic processes;transport;signal transduction","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","STAM2","ENSG00000115145","Endocytosis; JAK-STAT signaling pathway","Ub-specific processing proteases; Endosomal Sorting Complex Required For Transport (ESCRT); RHOU GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell","EGF/EGFR signaling pathway",1100.3,1135.9,1085,1165.2,1212,1007.9,0.9811231573661044,-0.027493850013549034,0.7543181344973434,0.12244545132229286,0.8342126259708099,0.07872324130874997,6609]
["O75907","Diacylglycerol O-acyltransferase 1 [OS=Homo sapiens]",9,3,6,3,488,55.2,9.32,23.89,"cell organization and biogenesis;other metabolic processes;other biological processes","plasma membrane;other membranes;ER/Golgi","other molecular function","DGAT1","ENSG00000185000; ENSG00000285482","Glycerolipid metabolism; Retinol metabolism; Metabolic pathways; Fat digestion and absorption","Neutrophil degranulation; Acyl chain remodeling of DAG and TAG; Triglyceride biosynthesis","Triacylglyceride synthesis; Statin inhibition of cholesterol production; Glycerolipids and glycerophospholipids; Congenital generalized lipodystrophy (CGL); Vitamin A and carotenoid metabolism",504.1,484.7,466.4,416.8,415.5,494.6,1.0966915366644057,0.13315780003167663,0.20562230352206076,0.6869297798946098,0.4413783895573398,0.3551889342594408,3405]
["O75909","Cyclin-K [OS=Homo sapiens]",12,5,9,5,580,64.2,8.41,32.68,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","CCNK","ENSG00000090061","","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; RNA polymerase II transcribes snRNA genes","Male infertility",614.6,653.5,678.7,628.6,647.2,576.7,1.0509041835357622,0.07163113719794331,0.3267442818684474,0.485792003976063,0.5393346784499734,0.2681416542987752,4428]
["O75915","PRA1 family protein 3 [OS=Homo sapiens]",28,6,74,6,188,21.6,9.77,239.08,"other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi","","ARL6IP5","ENSG00000144746","","Glutamate Neurotransmitter Release Cycle","",7340.9,6875.2,7074.3,6170.4,6535.6,8579.9,1.0002114075514776,3.0496439137133125E-4,0.9985232151610942,6.4183354825550964E-4,0.9994804409219991,2.2570027799119694E-4,7302]
["O75925","E3 SUMO-protein ligase PIAS1 [OS=Homo sapiens]",4,2,4,1,651,71.8,7.3,11.56,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PIAS1","ENSG00000033800","Ubiquitin mediated proteolysis; JAK-STAT signaling pathway; Hepatitis C","SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of transcription cofactors; SUMOylation of intracellular receptors; Regulation of IFNG signaling; SUMOylation of transcription factors; Formation of Incision Complex in GG-NER","Androgen receptor signaling pathway; Interleukin-11 signaling pathway; Mesodermal commitment pathway; TGF-beta signaling pathway; Immune response to tuberculosis; Interferon type I signaling pathways",420.1,373.5,388.8,470.5,467,382.3,0.8958933171692681,-0.15860114826778332,0.2247683023617049,0.6482649345621783,0.4562153629440992,0.3408300940494906,3601]
["O75928-1","E3 SUMO-protein ligase PIAS2 [OS=Homo sapiens]",4,2,4,1,621,68.2,7.52,10.58,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PIAS2","ENSG00000078043; ENSPTRG00000009998","Ubiquitin mediated proteolysis; JAK-STAT signaling pathway","Activation of anterior HOX genes in hindbrain development during early embryogenesis","Androgen receptor signaling pathway; TGF-beta signaling pathway",62.5,68.7,64.3,65.8,72.4,40.1,1.0964666292765004,0.13286190456971989,0.5979308974524808,0.22334900428780202,0.7183229667127191,0.1436802477847898,6084]
["O75934","Pre-mRNA-splicing factor spf27 [OS=Homo sapiens]",31,7,15,7,225,26.1,5.66,52.21,"RNA metabolism OR transcription;other metabolic processes","cytoskeleton;nucleus;other cell component","","BCAS2","ENSG00000116752","Spliceosome","mRNA Splicing - Major Pathway","",1104.3,1010.8,1076,1514.6,1671.1,2946.4,0.5203926876600186,-0.9423274048353946,0.09710916731889496,1.0127397698027931,0.3091336689607157,0.509853691644756,2296]
["O75935","Dynactin subunit 3 [OS=Homo sapiens]",45,7,19,7,186,21.1,5.47,63.76,"cell cycle OR cell proliferation;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","DCTN3","ENSG00000137100","Amyotrophic lateral sclerosis; Huntington disease; Pathways of neurodegeneration; Salmonella infection","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic","",2442.4,2224.7,2631.6,2600.6,2898.2,2779.9,0.8816239264618843,-0.18176471703148955,0.08881003438313753,1.0515379617999483,0.29531962752791274,0.529707688003447,2198]
["O75937","DnaJ homolog subfamily C member 8 [OS=Homo sapiens]",12,3,7,3,253,29.8,9.06,20.11,"","non-structural extracellular;cytosol;nucleus","other molecular function","DNAJC8","ENSG00000126698; ENSG00000285317","","mRNA Splicing - Major Pathway","mRNA processing",1356.9,1100.7,1358.9,947.1,826.4,502,1.6772137991650187,0.7460666050232967,0.031438317569283177,1.5025407034063947,0.1756748188944119,0.7552904855106701,1308]
["O75940","Survival of motor neuron-related-splicing factor 30 [OS=Homo sapiens]",29,4,9,4,238,26.7,7.24,25.68,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","SMNDC1","ENSG00000119953","Spliceosome","mRNA Splicing - Major Pathway","",346.7,305.4,289.3,424.6,410.3,895.7,0.5439731884895411,-0.8783925496367812,0.17630022903631098,0.7537471234968129,0.40959261730018975,0.387647879900108,3146]
["O75943-1","cell cycle checkpoint protein RAD17 [OS=Homo sapiens]",5,3,6,3,681,77,7.06,17.38,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","other molecular function","RAD17","ENSG00000152942; ENSG00000276618","","Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA)","miRNA regulation of DNA damage response; Gastric cancer network 2; DNA damage response",459.3,472.8,464.2,485,449.7,308.9,1.1227886780315215,0.1670864211984403,0.3987460306047288,0.39930362718251955,0.5804490614797775,0.23623588667289347,5021]
["O75947-1","ATP synthase subunit d, mitochondrial [OS=Homo sapiens]",41,6,30,6,161,18.5,5.3,46.16,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","ATP5PD","ENSG00000167863; ENSGGOG00000013716; ENSPTRG00000009628","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",1787.5,1868.2,1849.3,2101.4,2263.5,1748.1,0.9005398331424832,-0.15113800331311467,0.25877101450671536,0.5870843715303088,0.48621011440349166,0.31317601097204356,3890]
["O75955","Flotillin-1 [OS=Homo sapiens]",43,17,73,16,427,47.3,7.49,227.45,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","FLOT1","ENSG00000137312; ENSG00000206379; ENSG00000206480; ENSG00000230143; ENSG00000232280","Insulin signaling pathway","RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Regulation of necroptotic cell death; Synaptic adhesion-like molecules","Angiopoietin-like protein 8 regulatory pathway; Insulin signaling",5516.6,5558.7,5742.6,5138.6,4898,5841.8,1.059168430068521,0.0829320264436106,0.34320583191453774,0.4644453410250118,0.5477055514112131,0.26145285714490807,4580]
["O75962-1","Triple functional domain protein [OS=Homo sapiens]",4,7,9,6,3097,346.7,6.37,31.13,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;other cell component","enzyme regulator activity;kinase activity;other molecular function","TRIO","ENSG00000038382","","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; G alpha (q) signalling events; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; DCC mediated attractive signaling","Microtubule cytoskeleton regulation; Cell migration and invasion through p75NTR; Neural crest cell migration during development; Neural crest cell migration in cancer",309.6,313,317.3,345.4,310.9,370.8,0.9151007691558759,-0.1279974759095625,0.17206739427653595,0.7643014180359323,0.40451610960669065,0.3930641781951512,3109]
["O75962-3","Isoform 3 of Triple functional domain protein [OS=Homo sapiens]",4,2,2,1,596,66.2,7.08,5.3,"","","","TRIO","","","","",200.5,214.3,193.7,190.7,183.2,353.7,0.8363111599780101,-0.2578882800503953,0.5171806775935551,0.2863577091807655,0.6605056041466528,0.18012349320518162,5723]
["O75964","ATP synthase subunit g, mitochondrial [OS=Homo sapiens]",30,3,27,3,103,11.4,9.64,83.87,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","ATP5MG","ENSG00000167283","Oxidative phosphorylation; Metabolic pathways; Thermogenesis","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",3098,3000.3,3276.7,2797.8,2748.8,1744.5,1.2858142118473206,0.3626822017561258,0.12019263548150748,0.9201221418817604,0.3445050873467993,0.4628043604317426,2550]
["O75976","Carboxypeptidase D [OS=Homo sapiens]",11,11,15,11,1380,152.8,6.05,44.86,"protein metabolism;other metabolic processes","non-structural extracellular;plasma membrane;other membranes","other molecular function","CPD","ENSG00000108582","","Golgi Associated Vesicle Biogenesis; RND3 GTPase cycle; RND1 GTPase cycle","",1214.6,1222.7,1225,1315.8,1350.9,1142,0.9615616877149684,-0.056548680165996915,0.4924189577290739,0.3076652354347958,0.6424652199289185,0.19215037803837223,5602]
["O75995","SAM and SH3 domain-containing protein 3 [OS=Homo sapiens]",59,12,44,12,380,41.6,5.27,179.05,"other biological processes","nucleus;other cell component","","SASH3","ENSG00000122122","","","",3298,3320.1,2981.3,3914.9,3524.3,4284.5,0.8188029376391414,-0.2884118165247948,0.044685427306283027,1.349834084750121,0.2097660810415046,0.6782647354342682,1557]
["O76003","glutaredoxin-3 [OS=Homo sapiens]",36,11,63,11,335,37.4,5.39,205.95,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","GLRX3","ENSG00000108010","","Iron uptake and transport","",8918.5,9068.8,9145.7,9436.3,9781.2,9935.1,0.9307231601984044,-0.10357598704127455,0.014154430283903615,1.849107606308505,0.12185480676684514,0.9141573346684846,849]
["O76021","Ribosomal L1 domain-containing protein 1 [OS=Homo sapiens]",44,21,75,21,490,54.9,10.13,204.17,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","RSL1D1","ENSG00000171490","","","Senescence and autophagy in cancer",8934.5,8950.7,8710.6,17856.3,17706.9,16358.4,0.5122299775045454,-0.9651364078801404,6.2716920682897163E-5,4.20261527307961,0.011459949331782385,1.9408173025235995,40]
["O76024","Wolframin [OS=Homo sapiens]",18,13,34,13,890,100.2,8.05,95.23,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","WFS1","ENSG00000109501","Protein processing in endoplasmic reticulum","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; XBP1(S) activates chaperone genes","CAMKK2 pathway",3182.3,3151.1,3114.6,2999.6,3124.4,3463.7,0.9854292478905264,-0.02117580289992051,0.7561819839180897,0.12137367394275782,0.8357680508781669,0.07791423476276652,6613]
["O76031","ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial [OS=Homo sapiens]",46,25,57,25,633,69.2,7.58,171.36,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","CLPX","ENSG00000166855","","","",6519.1,6543.8,6587.5,7453.4,7718.1,7069.6,0.8835174519245902,-0.1786694625933306,0.010326717268881928,1.986037713193601,0.10615749158686079,0.9740493520393941,711]
["O76039-1","Cyclin-dependent kinase-like 5 [OS=Homo sapiens]",2,2,4,1,1030,115.5,9.54,11.44,"","","","CDKL5","","","","",227.8,249.8,246,219.9,161.5,103.8,1.4913437757625723,0.5766128575007309,0.08079477268779846,1.0926167365803883,0.28227963364011416,0.5493204548916519,2092]
["O76062","Delta(14)-sterol reductase [OS=Homo sapiens]",16,4,8,4,418,46.4,8.87,24.51,"other metabolic processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","other molecular function","TM7SF2","ENSG00000149809","Steroid biosynthesis; Metabolic pathways","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways",682,691.2,713.6,582.3,511.7,578,1.248086124401914,0.31971749105949826,0.005000668600902554,2.300971925609949,0.0736892879112838,1.1325956402161732,496]
["O76071","Probable cytosolic iron-sulfur protein assembly protein Ciao1 [OS=Homo sapiens]",43,10,29,10,339,37.8,4.97,123.12,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;other cell component","","CIAO1","ENSG00000144021","","Cytosolic iron-sulfur cluster assembly","",3325.3,3322.7,3206.7,3328.8,3171.5,2221.2,1.1299317777905178,0.17623566926478096,0.3389868873624843,0.4698171007829252,0.5463407187943545,0.26253643029506624,4535]
["O76074","cGMP-specific 3',5'-cyclic phosphodiesterase [OS=Homo sapiens]",18,14,21,14,875,99.9,6.09,54.97,"other metabolic processes;signal transduction","cytosol","other molecular function","PDE5A","ENSG00000138735","Purine metabolism; Metabolic pathways; cGMP-PKG signaling pathway","cGMP effects; RHOBTB1 GTPase cycle","Phosphodiesterases in neuronal function",1239.3,1221.9,1187.4,1482,1500.7,1847,0.7554506491086403,-0.4045905825306692,0.030202359373972785,1.519959129126514,0.1720569327080024,0.7643278236174696,1283]
["O76075","DNA fragmentation factor subunit beta [OS=Homo sapiens]",12,3,6,3,338,39.1,9,17.17,"cell organization and biogenesis;DNA metabolism;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DFFB","ENSG00000169598","Apoptosis","Apoptosis induced DNA fragmentation","Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis",472.4,436.7,488.1,508.8,422.7,3393.7,0.32303708499028944,-1.6302282975830136,0.3740848873478494,0.427029836506447,0.5674940725665071,0.24603867028479864,4818]
["O76080","AN1-type zinc finger protein 5 [OS=Homo sapiens]",8,1,1,1,213,23.1,8.51,4.43,"developmental processes;signal transduction;other biological processes","other cell component","nucleic acid binding activity;other molecular function","ZFAND5","ENSG00000107372","","","",68.6,65.8,54.4,108.3,110.2,108.1,0.5780771586037966,-0.7906660261998539,4.7311367962383632E-4,3.325034494565561,0.023364783002504184,1.6314382480765455,148]
["O76094","Signal recognition particle subunit SRP72 [OS=Homo sapiens]",38,21,73,21,671,74.6,9.26,247.63,"transport","cytosol;ER/Golgi;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","SRP72","ENSG00000174780","Protein export","SRP-dependent cotranslational protein targeting to membrane","",9683.1,10203.3,10051.9,10519.1,9201.6,8103.1,1.0759960896786205,0.10567283494703401,0.38021362517267754,0.41997232400060724,0.5696968811781673,0.2443561580943461,4878]
["O76095-1","Protein JTB [OS=Homo sapiens]",9,1,1,1,146,16.3,8.28,3.64,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion;other cell component","other molecular function","JTB","ENSG00000143543; ENSGGOG00000005608; ENSPPAG00000028370; ENSPTRG00000001369","","","",57.6,58.4,53.1,71.7,76.3,67.8,0.783595922150139,-0.3518182050780338,6.250992618485645E-3,2.2040510139355978,0.08129627232831242,1.089929367620686,562]
["O77932","Decapping and exoribonuclease protein [OS=Homo sapiens]",5,2,3,2,396,44.9,7.69,7.27,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus","nucleic acid binding activity;other molecular function","DXO","ENSG00000204348; ENSG00000206346; ENSG00000224313; ENSG00000225682; ENSG00000234798; ENSG00000236765","","","",353.1,351.8,392,384.9,367.5,363.2,0.9832377196127647,-0.024387832498127274,0.6945677570415244,0.15828538120947863,0.7919806140743373,0.10128544884432307,6410]
["O94760-1","N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 [OS=Homo sapiens]",33,8,25,7,285,31.1,5.81,85.27,"other metabolic processes;signal transduction;other biological processes","cytosol","other molecular function","DDAH1","ENSG00000153904; ENSMFAG00000037521; ENSMMUG00000014573; ENSMNEG00000044101; ENSRBIG00000034663; ENSRROG00000009892","","eNOS activation","Mesodermal commitment pathway; Nitric oxide metabolism in cystic fibrosis",3035.3,3062.6,3064.1,2876.7,2912.8,2412.7,1.1170173855794785,0.15965164051603817,0.1183191265096821,0.9269450451760164,0.34222180279353637,0.4656923252119582,2527]
["O94761","ATP-dependent DNA helicase Q4 [OS=Homo sapiens]",7,6,8,6,1208,133,8.09,22.05,"","","","","","","","",456.6,473,469.7,461.1,447.4,518,0.98093235191027,-0.027774447666850166,0.7037355632912009,0.15259050133744034,0.7979527198410468,0.09802284062978307,6446]
["O94762-1","ATP-dependent DNA helicase Q5 [OS=Homo sapiens]",6,5,7,5,991,108.8,8.56,19.38,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RECQL5","ENSG00000108469","","","",624.3,618.8,599.4,760.7,768.6,1122.2,0.6948896850839147,-0.525144129158314,0.08690319097925071,1.0609642764945182,0.29284251861103894,0.5333658666247386,2169]
["O94763-1","Unconventional prefoldin RPB5 interactor 1 [OS=Homo sapiens]",10,5,6,5,535,59.8,5.05,19.81,"other biological processes","cytosol;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","URI1","ENSG00000105176","","","",674.8,695.5,706.5,787.8,830.6,502.8,0.9790684518197248,-0.030518365141607214,0.8929997368231208,0.04914866910281217,0.9310891692496706,0.03100872518549784,7010]
["O94766","Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 [OS=Homo sapiens]",18,4,7,4,335,37.1,8.27,23.83,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","enzyme regulator activity;other molecular function","B3GAT3","ENSG00000149541","Glycosaminoglycan biosynthesis; Glycosaminoglycan biosynthesis; Metabolic pathways","A tetrasaccharide linker sequence is required for GAG synthesis; Defective B3GAT3 causes JDSSDHD","Proteoglycan biosynthesis",581.1,550.1,574.1,565.6,560.6,748,0.9098815494611034,-0.1362493508154537,0.41767743354299647,0.3791589883511117,0.5926624658834714,0.22719257634771775,5151]
["O94768","Serine/threonine-protein kinase 17B [OS=Homo sapiens]",16,5,12,5,372,42.3,5.25,31.11,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus","kinase activity;other molecular function","STK17B","ENSG00000081320","","","",813.1,825.9,833.4,922.7,877.1,2321,0.5999805862939235,-0.7370122750172203,0.31078439407821873,0.507540797258119,0.5292458379118594,0.27634254866805946,4292]
["O94776","Metastasis-associated protein MTA2 [OS=Homo sapiens]",41,28,99,27,668,75,9.66,247.68,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MTA2","ENSG00000149480","","Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation","Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome",10416.5,10341.4,10293,11132,10996.7,10456,0.9529288285606435,-0.06955962735959613,0.07127728606765935,1.1470488447214398,0.2647183352990458,0.5772159769327895,1968]
["O94788-1","retinal dehydrogenase 2 [OS=Homo sapiens]",3,2,5,1,518,56.7,6.05,11.85,"cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;other cell component","other molecular function","ALDH1A2","ENSG00000128918","Retinol metabolism; Metabolic pathways","RA biosynthesis pathway","Ethanol effects on histone modifications; Tryptophan metabolism; 22q11.2 copy number variation syndrome; Vitamin A and carotenoid metabolism",776.9,768.3,807.1,778.3,781,1723.3,0.7165966002558946,-0.48076689589020094,0.38031910916696765,0.4198518528758953,0.5697381366881259,0.2443247091041887,4879]
["O94804","Serine/threonine-protein kinase 10 [OS=Homo sapiens]",35,32,105,30,968,112.1,6.95,298.67,"cell adhesion;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol","kinase activity;other molecular function","STK10","ENSG00000072786","Progesterone-mediated oocyte maturation","RHOA GTPase cycle; RHOB GTPase cycle; Neutrophil degranulation; RHOC GTPase cycle","",10592.4,10820.4,10798.4,11283,10993.2,8945.6,1.0316893965114116,0.045008694055757345,0.678562167908715,0.1684103573736249,0.7790780529759344,0.10841902977463624,6366]
["O94806","Serine/threonine-protein kinase D3 [OS=Homo sapiens]",18,12,29,9,890,100.4,6.87,95.06,"protein metabolism;other metabolic processes;signal transduction","other membranes;cytosol;nucleus","kinase activity;other molecular function","PRKD3","ENSG00000115825","Rap1 signaling pathway; Aldosterone synthesis and secretion; Chemical carcinogenesis","Sphingolipid de novo biosynthesis","G protein signaling pathways; Hippo signaling regulation pathways",2392.4,2268.5,2387.1,2691.5,2633.2,3264.2,{"$f":"AVERAGE(S706:U706)/AVERAGE(V706:X706)","v":0.8205940225174353},{"$f":"LOG(Y706,2)","v":-0.28525944969403594},{"$f":"TTEST(V706:X706,S706:U706,2,2)","v":0.066671598097076},1.1760591348485838,{"$f":"AA706*7309/AE706","v":0.2549988019317261},0.5934618600196236,1911]
["O94811","Tubulin polymerization-promoting protein [OS=Homo sapiens]",24,4,5,4,219,23.7,9.44,10.69,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","TPPP","ENSG00000171368","","","Microtubule cytoskeleton regulation; Glial cell differentiation; Sudden infant death syndrome (SIDS) susceptibility pathways",430.5,479.9,464.6,435.5,410.6,309.8,1.1895492689679037,0.25041502680604033,0.15027897632364598,{"$f":"-LOG10(AA707)","v":0.8231017719431353},0.38112041566604044,{"$f":"-LOG10(AC707)","v":0.41893778653713276},2882]
["O94813","Slit homolog 2 protein [OS=Homo sapiens]",0,1,1,1,1529,169.8,7.06,1.9,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;other membranes;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","SLIT2","ENSG00000145147","Axon guidance","Regulation of expression of SLITs and ROBOs; Netrin-1 signaling; Inactivation of CDC42 and RAC1; Activation of RAC1; Regulation of commissural axon pathfinding by SLIT and ROBO; Role of ABL in ROBO-SLIT signaling; SLIT2:ROBO1 increases RHOA activity","Spinal cord injury; Robo4 and VEGF signaling pathways crosstalk; Genes controlling nephrogenesis; GDNF/RET signaling axis; Development of ureteric collection system",175.4,166.4,188.6,172.1,165.3,13.5,1.511541749786264,0.5960208277104212,0.31536839677732903,0.5011818296909878,0.5334477232227488,0.272908134118245,4321]
["O94822","E3 ubiquitin-protein ligase listerin [OS=Homo sapiens]",20,28,49,28,1766,200.4,6.25,119.14,"protein metabolism;other metabolic processes","cytosol;other cell component","translation activity;other molecular function","LTN1","ENSG00000198862","","Antigen processing: Ubiquitination & Proteasome degradation","",4214.9,4266.9,4213.2,4862.3,4536.2,4651.4,0.9035651499298928,-0.14629946713213457,0.009649719087698325,2.0154853291886683,0.10356798357119978,0.9847744792174804,681]
["O94826","Mitochondrial import receptor subunit TOM70 [OS=Homo sapiens]",57,28,155,28,608,67.4,7.12,436.56,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","TOMM70","ENSG00000154174","","Mitochondrial protein import; Ub-specific processing proteases; DDX58/IFIH1-mediated induction of interferon-alpha/beta; PINK1-PRKN Mediated Mitophagy","Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation",20407.9,20286.6,20913.2,18930.9,19424.1,14765.8,1.15976604268008,0.21383380267398877,0.13041519523077202,0.8846718041531029,0.3558061448084034,0.4487865558773388,2679]
["O94829","Importin-13 [OS=Homo sapiens]",13,11,22,11,963,108.1,5.3,61.34,"transport","nucleus;other cell component","other molecular function","IPO13","ENSG00000117408","Nucleocytoplasmic transport","","",1658.7,1666.5,1647.2,1528.8,1463.9,2174.7,0.9622634206757751,-0.05549620746141715,0.7887981522390178,0.10303411540119907,0.8587020695136999,0.06615749042921981,6714]
["O94830","Phospholipase DDHD2 [OS=Homo sapiens]",5,3,3,3,711,81,5.39,2.46,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","DDHD2","ENSG00000085788","","Synthesis of PA","",73.7,89.9,85.6,85.4,77.2,94.5,0.9692726565538702,-0.04502554180965402,0.72438183578818,0.14003244835779433,0.8124147365008145,0.09022220746942079,6517]
["O94832","Unconventional myosin-Id [OS=Homo sapiens]",39,37,92,37,1006,116.1,9.39,237.91,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","MYO1D","ENSG00000176658","Pathogenic Escherichia coli infection","","",10854.2,11076.8,11094.6,9151.4,8683.2,9277.3,1.218121931697889,0.2846585515130765,5.5616891800347619E-4,3.2547932857285375,0.0254064913855463,1.595055306500489,160]
["O94842","TOX high mobility group box family member 4 [OS=Homo sapiens]",11,5,6,4,621,66.2,5.06,17.83,"other biological processes","nucleus;other cell component","nucleic acid binding activity","TOX4","ENSG00000092203","","","",534.2,528.4,505.9,648.7,697,598.9,0.8065926154479072,-0.3100878973080312,0.01332204513729559,1.8754290992150258,0.11976731600060697,0.921661682925121,813]
["O94854","Uncharacterized protein KIAA0754 [OS=Homo sapiens]",2,1,1,1,1291,135.1,4.21,2.88,"","","","KIAA0754","","","","",12.7,14.5,18.4,17.9,16.3,5.2,1.1573604060913703,0.210838194708365,0.6583036082771867,0.18157376445740211,0.7626471822631095,0.1176763299794127,6309]
["O94855","Protein transport protein Sec24D [OS=Homo sapiens]",22,19,48,18,1032,112.9,7.25,143.74,"cell organization and biogenesis;transport;developmental processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","SEC24D","ENSG00000150961","Protein processing in endoplasmic reticulum; Pathogenic Escherichia coli infection","MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Sterol regulatory element-binding proteins (SREBP) signaling",3566.7,3631.1,3685.2,4096.1,3868.7,3572,0.943329172734207,-0.0841668107265043,0.233816621009619,0.6311246199654863,0.46325987610715785,0.33417531330831673,3689]
["O94864-1","STAGA complex 65 subunit gamma [OS=Homo sapiens]",17,3,4,3,414,46.2,5.12,5.49,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","SUPT7L","ENSG00000119760; ENSPTRG00000011777","","HATs acetylate histones","",404.5,374,367.5,410.9,490.8,375.1,0.8975563909774434,-0.15592551257807882,0.29309613392988904,0.5329899100637455,0.5157052582796242,0.28759844037885285,4154]
["O94868","F-BAR and double SH3 domains protein 2 [OS=Homo sapiens]",13,8,12,8,740,84.2,5.77,33.34,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","FCHSD2","ENSG00000137478","","","",778.1,784.4,755.7,1063.9,1058.2,1040.8,0.7329349647475416,-0.44824290498502467,1.4552199119813901E-5,4.8370713713906435,0.00709080155778132,2.149304668562352,15]
["O94874-1","E3 UFM1-protein ligase 1 [OS=Homo sapiens]",51,38,145,15,794,89.5,6.79,367.15,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","UFL1","ENSG00000014123","","Antigen processing: Ubiquitination & Proteasome degradation","",14533.9,15403.2,15443.2,13778.2,13336.4,12167.2,1.155250014001395,0.2082051069896177,0.02277202807540581,1.642598289422834,0.14967693633375995,0.8248451147848996,1112]
["O94874-3","Isoform 3 of E3 UFM1-protein ligase 1 [OS=Homo sapiens]",52,23,71,1,509,57.5,6.3,196.23,"","","","UFL1","","","","",45.3,49.7,38.8,51.3,34.9,11.4,1.3709016393442623,0.4551250630785747,0.3716582218959276,0.4298562552072292,0.5661629728714745,0.24705853695506808,4798]
["O94876","Transmembrane and coiled-coil domains protein 1 [OS=Homo sapiens]",11,5,7,5,653,72,6.55,21.85,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","TMCC1","ENSG00000172765","","","",199.5,189,187.9,177.2,164.3,316,0.8766539923954373,-0.1899205588922795,0.6084059180345197,0.21580657016598953,0.7267264021758955,0.13862906147866536,6119]
["O94880","PHD finger protein 14 [OS=Homo sapiens]",9,7,14,7,888,100,5.33,29.98,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","PHF14","ENSG00000106443","","","",1569.3,1541.4,1523.3,1787.5,1894.9,2230.1,0.7837632135306555,-0.35151023424929795,0.03349289355626236,1.4750473307750616,0.18133300666868263,0.7415231373860948,1350]
["O94886","CSC1-like protein 1 [OS=Homo sapiens]",18,10,23,10,807,92.1,7.27,71.54,"transport","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","transporter activity;nucleic acid binding activity","TMEM63A","ENSG00000196187","","Neutrophil degranulation","",2114.9,2115.4,2115.5,1983.4,1961.1,2328.4,1.0116214191203432,0.016669488704892214,0.8480282490174504,0.07158968054038886,0.901693114935779,0.044941246457622444,6874]
["O94887-1","FERM, RhoGEF and pleckstrin domain-containing protein 2 [OS=Homo sapiens]",11,7,7,7,1054,119.8,8.79,30.06,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity","FARP2","ENSG00000006607","Rap1 signaling pathway; Adherens junction","RAC1 GTPase cycle; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion","",545.1,576.6,580,500.7,469,1188.4,0.788517677586766,-0.3427849960784465,0.5525999673865952,0.2575891450507455,0.6860800342498088,0.16362521897894156,5887]
["O94888","UBX domain-containing protein 7 [OS=Homo sapiens]",42,16,38,15,489,54.8,5.16,97.06,"","other membranes;cytosol;ER/Golgi;nucleus","other molecular function","UBXN7","ENSG00000163960","","Neddylation","3q29 copy number variation syndrome",3859.7,3835,3808.2,4127.1,4283.4,6674,0.762564221551924,-0.3910692514715101,0.22109032680326512,0.6554302583614259,0.45417346784852863,0.34277824022535913,3558]
["O94901-9","Isoform 9 of SUN domain-containing protein 1 [OS=Homo sapiens]",21,14,35,13,916,101.9,7.31,101.23,"","","","SUN1","","","","",2030.6,1929.7,1965.2,1782,1924.9,2456.9,0.9613387845160454,-0.056883155450359255,0.7212716195502126,0.14190115600516962,0.8100452162403969,0.09149073838601787,6508]
["O94903","Pyridoxal phosphate homeostasis protein [OS=Homo sapiens]",43,11,42,11,275,30.3,7.5,111.97,"","cytosol;other cell component","other molecular function","PLPBP","ENSG00000147471","","","",4488,4520.9,4761.5,4418.8,4563.5,4315.3,1.0355552881723018,0.05040458092942172,0.23318592536001706,0.6322976662755707,0.46238630723178636,0.3349950352746528,3686]
["O94905-1","Erlin-2 [OS=Homo sapiens]",32,10,32,7,339,37.8,5.62,86.04,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","ERLIN2","ENSG00000147475; ENSGGOG00000012855; ENSPPAG00000034728; ENSPTRG00000020158","","ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Signaling by FGFR1 in disease; Signaling by plasma membrane FGFR1 fusions","",2993.2,3075.3,3188.4,2778.5,2740.5,2371.1,1.1732297436027426,0.23048555173106008,0.03243914266772676,1.488930632253594,0.17867196213897127,0.7479435932340565,1327]
["O94906-1","Pre-mRNA-processing factor 6 [OS=Homo sapiens]",54,49,151,49,941,106.9,8.25,459.51,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PRPF6","ENSG00000101161; ENSGGOG00000016876; ENSPPAG00000008686; ENSPTRG00000013765","Spliceosome","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","mRNA processing; mRNA Processing",19141.4,18875.1,19322.6,18138.1,17969.8,17196.7,1.0756876517223655,0.10525922219865752,0.01333083210601269,1.8751427412259865,0.11969908091258816,0.9219091842312147,814]
["O94913","Pre-mRNA cleavage complex 2 protein Pcf11 [OS=Homo sapiens]",9,13,22,13,1555,172.9,8.48,58.17,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","PCF11","ENSG00000165494","mRNA surveillance pathway","RNA polymerase II transcribes snRNA genes; mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs","",2610.2,2728,2522,2663.5,2816.9,2522.7,0.982144419037623,-0.025992914227157007,0.6701862342380422,0.17380449690638108,0.7722514876313812,0.11224124641987183,6343]
["O94915-1","protein furry homolog-like [OS=Homo sapiens]",9,26,41,20,3013,339.4,5.58,118.14,"cell organization and biogenesis;developmental processes;other biological processes","other cell component","","FRYL","ENSG00000075539","","","",4012.4,3997.9,3934.3,3780.5,3708.1,3843.5,1.0540499995587755,0.07594330379163641,0.011251285932904288,1.94879783829496,0.10994070706363296,0.9588414742754483,748]
["O94915-2","Isoform 2 of Protein furry homolog-like [OS=Homo sapiens]",19,7,12,1,403,45.6,4.5,39.26,"","","","FRYL","","","","",304.1,327.8,314,300.7,286.7,341.2,1.0186301959939696,0.02663038983782947,0.7612595234238588,0.11846726126276619,0.8394758383682838,0.07599179912609232,6628]
["O94916","nuclear factor of activated T-cells 5 [OS=Homo sapiens]",2,2,2,2,1531,165.7,5.24,2.25,"RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NFAT5","ENSG00000102908","","","Cancer immunotherapy by PD-1 blockade",84.3,79.4,82.5,100.1,112.7,130.2,0.7177842565597667,-0.4783778145757174,0.021801418985173748,1.6615152386258858,0.14740663400798792,0.831482970695223,1081]
["O94919","endonuclease domain-containing 1 protein [OS=Homo sapiens]",25,8,25,8,500,55,5.71,78.53,"other metabolic processes","non-structural extracellular;cytosol","nucleic acid binding activity;other molecular function","ENDOD1","ENSG00000149218","","Platelet degranulation","",1574.9,1579.4,1541.6,1378.2,1398.8,1541.6,1.0873662761079979,0.12083798978146737,0.07561858608670406,1.121371447318406,0.2719961839112795,0.5654371890463148,2032]
["O94921-1","Cyclin-dependent kinase 14 [OS=Homo sapiens]",14,6,12,4,469,53,8.92,26.99,"cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","CDK14","ENSCATG00000032271; ENSCSAG00000012501; ENSG00000058091; ENSGGOG00000003585; ENSMLEG00000038830; ENSMNEG00000032203; ENSPANG00000022338","Transcriptional misregulation in cancer","","",597.2,591.6,582,673,615.8,607.9,0.933621553224021,-0.09909022796111688,0.11614019424162152,0.935017451955236,0.33900506378275225,0.4697938146096552,2504]
["O94923","D-glucuronyl C5-epimerase [OS=Homo sapiens]",5,2,2,2,617,70.1,8.97,5.72,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","GLCE","ENSG00000138604","Glycosaminoglycan biosynthesis; Metabolic pathways","HS-GAG biosynthesis","",160.6,148.2,175.2,154.5,191.8,246.1,0.8170155300472652,-0.2915645931268911,0.2622909557905513,0.5812166843161476,0.4894267541161959,0.31031229398004045,3917]
["O94925-1","Glutaminase kidney isoform, mitochondrial [OS=Homo sapiens]",49,24,114,5,669,73.4,7.77,364.69,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;mitochondrion;other cell component","other molecular function","GLS","ENSG00000115419; ENSGGOG00000007590; ENSPTRG00000012747","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; D-Amino acid metabolism; Metabolic pathways; Glutamatergic synapse; GABAergic synapse; Proximal tubule bicarbonate reclamation; MicroRNAs in cancer; Central carbon metabolism in cancer","Glutamate Neurotransmitter Release Cycle; TP53 Regulates Metabolic Genes; Glutamate and glutamine metabolism","Amino acid metabolism; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling",13370.8,13287.3,13450.6,12737.1,12722.9,9590.2,1.144321573058071,0.19449252996930916,0.18280422193285273,0.7380137782905499,0.41623553212062947,0.380660848811449,3210]
["O94925-3","Isoform 3 of Glutaminase kidney isoform, mitochondrial [OS=Homo sapiens]",50,22,119,3,598,65.4,7.88,372.88,"","","","GLS","","","","",2385.4,2353.2,2445.5,2522.8,2554.2,1950,1.0223566244485556,0.03189853343545716,0.8047002122698524,0.09436588411157709,0.8704386342282597,0.060261841152579224,6757]
["O94927","HAUS augmin-like complex subunit 5 [OS=Homo sapiens]",6,3,5,3,633,71.6,8.51,15.7,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","","HAUS5","ENSG00000249115","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",215,204.9,221.3,232.9,213,223.9,0.957300686772171,-0.0629559505521674,0.27136218035251164,0.5664506799213893,0.4979628863159698,0.30280302444674434,3983]
["O94941-1","RING finger protein 37 [OS=Homo sapiens]",3,1,4,1,541,58.9,7.56,12.59,"protein metabolism;other metabolic processes","nucleus;other cell component","other molecular function","UBOX5","ENSG00000185019","Ubiquitin mediated proteolysis","Antigen processing: Ubiquitination & Proteasome degradation","",30,30.4,35,40.5,35.9,63.2,0.6833810888252149,-0.5492377702041408,0.1614444747182531,0.7919768137030918,0.39307050823308193,0.40552953972637046,3002]
["O94953","lysine-specific demethylase 4B [OS=Homo sapiens]",8,6,13,6,1096,121.8,7.09,46.78,"cell organization and biogenesis;protein metabolism;other metabolic processes","nucleus","other molecular function","KDM4B","ENSG00000127663","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Estrogen-dependent gene expression; HDMs demethylate histones","",449.8,434.4,425.8,454.6,461.1,446.6,0.9616090435293253,-0.05647763083331542,0.0999911685659774,1.000038356124356,0.313932753886911,0.5031633702182339,2328]
["O94964-2","Isoform 2 of Protein SOGA1 [OS=Homo sapiens]",3,5,5,3,1661,183.7,6.52,15.95,"","","","SOGA1","","","","",209.3,221,263.7,290.8,299.1,1118.2,0.4062993969908085,-1.2993848714924097,0.28624320328725233,0.5432648166516552,0.5100320752868179,0.2924025108000297,4102]
["O94966-5","Isoform 5 of Ubiquitin carboxyl-terminal hydrolase 19 [OS=Homo sapiens]",14,12,20,12,1419,155.9,6.38,58.78,"","","","USP19","","","","",812.7,862.4,830.7,926.5,885.7,838.2,0.9454421974041655,-0.08093883773560533,0.17600515547333273,0.7544746108175102,0.4092973850953194,0.38796102995111736,3143]
["O94973","AP-2 complex subunit alpha-2 [OS=Homo sapiens]",37,28,67,18,939,103.9,6.96,194.09,"transport","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","AP2A2","ENSG00000183020","Endocytosis; Synaptic vesicle cycle; Endocrine and other factor-regulated calcium reabsorption; Huntington disease","Neutrophil degranulation; MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; Recycling pathway of L1; Potential therapeutics for SARS; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation","Synaptic vesicle pathway; GABA receptor signaling; mBDNF and proBDNF regulation of GABA neurotransmission",3394.7,3456.8,3456.8,3156.2,3140.9,3008.8,1.1077166098926485,0.14758884005490483,2.8405099062662675E-3,2.546603691783915,0.05580991103467782,1.2532886697818397,372]
["O94979","Protein transport protein Sec31A [OS=Homo sapiens]",41,39,144,39,1220,132.9,6.89,421.07,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","SEC31A","ENSG00000138674","Protein processing in endoplasmic reticulum","Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Signaling by ALK fusions and activated point mutants; MHC class II antigen presentation; COPII-mediated vesicle transport; XBP1(S) activates chaperone genes","Sterol regulatory element-binding proteins (SREBP) signaling",17414.9,18262.1,18328.7,17881,16696.8,16012.8,1.067504635248445,0.09424233423492387,0.14020023635562545,0.8532512542163118,0.36794381598681025,0.4342184918420865,2785]
["O94986-1","Isoform 1 of Centrosomal protein of 152 kDa [OS=Homo sapiens]",6,6,6,6,1275,147.3,5.43,14.01,"","","","CEP152","","","","",333.4,358.3,382.3,434.1,455.4,1351.4,0.47927172118345307,-1.0610842767998363,0.26803355285965563,0.5718108369051637,0.494961404206979,0.3054286648915682,3958]
["O94992","Protein HEXIM1 [OS=Homo sapiens]",4,2,2,2,359,40.6,4.89,2.06,"stress response;developmental processes;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","HEXIM1","ENSG00000186834","","","Initiation of transcription and translation elongation at the HIV-1 LTR",245,257.3,233.8,271.4,191,152,1.1980794270833335,0.26072355525590835,0.32047593159354104,0.49420458133585354,0.5355186520386811,0.27122539815349894,4374]
["O95067","G2/mitotic-specific cyclin-B2 [OS=Homo sapiens]",12,3,3,3,398,45.3,8.9,12.41,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity","CCNB2","ENSG00000157456","FoxO signaling pathway; Cell cycle; Oocyte meiosis; p53 signaling pathway; Cellular senescence; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection; Human immunodeficiency virus 1 infection","Resolution of Sister Chromatid Cohesion; Initiation of Nuclear Envelope (NE) Reformation; The role of GTSE1 in G2/M progression after G2 checkpoint; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; Cyclin A/B1/B2 associated events during G2/M transition; Golgi Cisternae Pericentriolar Stack Reorganization; Polo-like kinase mediated events; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint","miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; TGF-beta signaling pathway; IL-18 signaling pathway; DNA damage response",389.1,431.4,407.8,364.3,327.7,299.4,1.23895501311277,0.3091238036710802,0.02440510646806299,1.6125192933796626,0.1545727237218998,0.8108671403154022,1154]
["O95070","protein YIF1A [OS=Homo sapiens]",2,1,3,1,293,32,8.95,3.54,"transport","other membranes;ER/Golgi;other cell component","","YIF1A","ENSG00000174851","","XBP1(S) activates chaperone genes","",244.2,240,254.2,215.1,237.3,832.4,0.574719800747198,-0.7990693398715405,0.418672508802231,0.37812555515239593,0.5932681983007961,0.22674893107034164,5158]
["O95071","E3 ubiquitin-protein ligase UBR5 [OS=Homo sapiens]",17,37,75,37,2799,309.2,5.85,229.82,"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","UBR5","ENSG00000104517","Ubiquitin mediated proteolysis","","Mesodermal commitment pathway",7177.4,7251.1,7280.8,7174.1,7110.2,7044.9,1.0178206402490484,0.025483352944761204,0.058705300219204094,1.2313226866222606,0.2394403121105819,0.6208027300643939,1792]
["O95081","Arf-GAP domain and FG repeat-containing protein 2 [OS=Homo sapiens]",2,1,1,1,481,48.9,9.11,3.14,"","","enzyme regulator activity;other molecular function","AGFG2","ENSG00000106351","","","",74.3,80.4,83.1,55.8,67.2,77.5,1.1860349127182046,0.2461464784033733,0.14086388046330386,0.8512003520036947,0.3686266030455739,0.4334133258207269,2793]
["O95104","Splicing factor, arginine/serine-rich 15 [OS=Homo sapiens]",16,15,30,14,1147,125.8,9.55,88.37,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","SCAF4","ENSG00000156304","","","",2378.6,2302.5,2225.1,2597.2,2561.5,2973,0.8492935056630226,-0.23566487681183565,0.04233035518982677,1.3733480873886257,0.202614647074292,0.693329162561074,1527]
["O95136","Sphingosine 1-phosphate receptor 2 [OS=Homo sapiens]",3,1,1,1,353,38.8,8.97,2.94,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","S1PR2","ENSG00000267534","Sphingolipid signaling pathway; Neuroactive ligand-receptor interaction","G alpha (i) signalling events; Lysosphingolipid and LPA receptors","Small ligand GPCRs; S1P receptor signal transduction; Sphingolipid metabolism in senescence",38.2,36.5,37.1,42.9,34.1,57.1,0.8337061894108876,-0.2623890490612835,0.33062728793997603,0.48066130529365086,0.54146422754947,0.2664302302502074,4463]
["O95139","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [OS=Homo sapiens]",31,4,13,4,128,15.5,9.63,34.02,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB6","ENSG00000165264","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",870.4,730.1,914.9,1164.8,1474.7,1949.2,0.548172685074204,-0.8672976530603785,0.04224323774301516,1.3742428025945757,0.2023301603300772,0.6939393743294645,1526]
["O95140","Mitofusin-2 [OS=Homo sapiens]",18,12,18,12,757,86.3,6.98,52.88,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion","other molecular function","MFN2","ENSG00000116688","Mitophagy; NOD-like receptor signaling pathway; Parkinson disease; Pathways of neurodegeneration","Factors involved in megakaryocyte development and platelet production; PINK1-PRKN Mediated Mitophagy; RHOT2 GTPase cycle","Intracellular trafficking proteins involved in CMT neuropathy",1160.3,1221,1176.3,1250.4,1203.6,3013.7,0.6506574976681238,-0.6200297779872601,0.34557191522371006,0.46146156005594824,0.5488450952564313,0.26055021250459987,4602]
["O95149","Snurportin-1 [OS=Homo sapiens]",5,2,5,2,360,41.1,6.64,11.37,"transport","cytosol;nucleus","nucleic acid binding activity;other molecular function","SNUPN","ENSG00000169371","Nucleocytoplasmic transport","snRNP Assembly","",559.2,564.2,559.6,648.7,679.4,706.4,0.827230277709511,-0.27363910374376144,2.1955120502833462E-3,2.658464174885168,0.04999064665271332,1.3011112454060674,321]
["O95155","Ubiquitin conjugation factor E4 B [OS=Homo sapiens]",21,21,35,20,1302,146.1,6.55,90.04,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","other molecular function","UBE4B","ENSG00000130939","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum","","",2623.6,2757.4,2712.8,2872.2,2844,2285.2,1.011547979103657,0.016564750517357833,0.8822369593328401,0.05441475238612268,0.9227632993365381,0.03490968681304304,6988]
["O95159","Zinc finger protein-like 1 [OS=Homo sapiens]",12,3,9,3,310,34.1,8.07,41.08,"transport;other biological processes","other membranes;ER/Golgi;nucleus","nucleic acid binding activity;other molecular function","ZFPL1","ENSG00000162300","","","",991,803.9,778.8,1088.1,1111.3,1463.7,0.7026016215773526,-0.5092211886389123,0.05895896176835847,1.2294501727447114,0.23980581611849308,0.6201402879697122,1797]
["O95163","Elongator complex protein 1 [OS=Homo sapiens]",21,22,60,22,1332,150.2,5.94,211.47,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","ELP1","ENSG00000070061","","HATs acetylate histones","",5467.5,5659.7,5580.2,5656.9,5616.5,4565.4,1.0548400131323084,0.0770242029482798,0.4681819202329322,0.32958536145246325,0.6245558778942328,0.20442870000320004,5479]
["O95166","Gamma-aminobutyric acid receptor-associated protein [OS=Homo sapiens]",6,1,1,1,117,13.9,8.79,2.91,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","GABARAP","ENSG00000170296","FoxO signaling pathway; Autophagy; Mitophagy; Autophagy; NOD-like receptor signaling pathway; GABAergic synapse","Macroautophagy; TBC/RABGAPs","Senescence and autophagy in cancer",108.8,109.4,122.8,233.3,245.6,81.6,0.6083853702051739,-0.7169426337812543,0.23907155407109165,0.6214720953392371,0.46871619868712683,0.3290900371372079,3728]
["O95167","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [OS=Homo sapiens]",49,3,11,3,84,9.3,8.46,20.56,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity","NDUFA3","ENSG00000170906; ENSG00000273642; ENSG00000274359; ENSG00000275605; ENSG00000275724; ENSG00000276061; ENSG00000276220; ENSG00000276766; ENSG00000277722; ENSG00000278365","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",1014.4,947.9,1080.1,1248.2,1493.8,758,0.8692571428571427,-0.20214507797646253,0.5255871151677903,0.2793552900999487,0.6665827216313343,0.17614594779733184,5763]
["O95168-1","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [OS=Homo sapiens]",14,1,1,1,129,15.2,9.85,5.37,"cell organization and biogenesis;other metabolic processes;stress response;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB4","ENSG00000065518; ENSGGOG00000013923; ENSPPAG00000027750; ENSPTRG00000015270","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",62.1,48.8,56,54.2,68,286,0.4088682018618324,-1.2902922276701205,0.344886345395758,0.4623239997081813,0.5488295881771381,0.26056248324213177,4593]
["O95169","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [OS=Homo sapiens]",28,4,7,4,186,21.8,6.8,13.42,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;ER/Golgi","transporter activity","NDUFB8","ENSG00000166136","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Mitochondrial protein import; Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",777.4,663.4,747.7,726.9,834.8,1961.3,0.621203519727505,-0.6868620908559167,0.32436416204877244,0.48896713560838373,0.5380793600577571,0.2691536665391595,4406]
["O95182","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [OS=Homo sapiens]",5,1,1,1,113,12.5,10.18,0,"protein metabolism;other metabolic processes;transport","other membranes;mitochondrion;translational apparatus","transporter activity;other molecular function","NDUFA7","ENSG00000267855","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",102,106.8,97.2,103.3,107.3,181.8,0.779816513761468,-0.35879338863922444,0.32478716187365286,0.4884011458028552,0.5380483604112712,0.26917868768703523,4412]
["O95183","vesicle-associated membrane protein 5 [OS=Homo sapiens]",16,2,2,1,116,12.8,7.85,5.66,"transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","VAMP5","ENSG00000168899","SNARE interactions in vesicular transport","","",52.1,58.9,57.3,38.7,38,81.8,1.0618296529968454,0.08655233630317939,0.8342468405376362,0.07870542943153783,0.8921009740292002,0.049585986451405925,6835]
["O95197","Reticulon-3 [OS=Homo sapiens]",3,4,20,4,1032,112.5,4.96,41.5,"cell organization and biogenesis;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","","RTN3","ENSG00000133318","Alzheimer disease","Synaptic adhesion-like molecules","Alzheimer's disease and miRNA effects; Alzheimer's disease",3905,3814.9,4033.6,3711.6,3401.7,5506,0.9313908061461412,-0.10254145364906263,0.6840320559963022,0.16492354533238157,0.7836348428333813,0.10588626216957098,6380]
["O95202-1","mitochondrial proton/calcium exchanger protein [OS=Homo sapiens]",48,34,143,34,739,83.3,6.7,456.4,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity;translation activity;other molecular function","LETM1","ENSG00000168924","","RHOG GTPase cycle; Mitochondrial calcium ion transport","",14034.6,14641.3,14904.9,12055.3,13086.7,8128.8,1.3098813373889415,0.38943612343101613,0.08833001298291994,1.0538917057296278,0.2947963766630876,0.5304778586857731,2190]
["O95208-1","epsin-2 [OS=Homo sapiens]",7,5,7,4,641,68.4,7.52,20.07,"transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","EPN2","ENSG00000072134","Endocytosis","Cargo recognition for clathrin-mediated endocytosis","",540.7,510.6,506.7,578.9,661.9,950,0.7111557421946321,-0.4917625520795058,0.13525094931041634,0.8688596779490931,0.36104791399190395,0.44243515986309134,2738]
["O95210","Starch-binding domain-containing protein 1 [OS=Homo sapiens]",39,15,34,15,358,39,5.73,84.87,"other metabolic processes;transport","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","STBD1","ENSG00000118804","","Neutrophil degranulation; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle","Exercise-induced circadian regulation",4727.1,4919.4,4846,4578.3,4673.6,5107.1,1.0092973048262412,0.01335120617822464,0.80872780955269,0.09219762263982127,0.8729864953508509,0.05899247455327272,6771]
["O95218-1","Zinc finger Ran-binding domain-containing protein 2 [OS=Homo sapiens]",35,13,50,13,330,37.4,10.01,133.31,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","ZRANB2","ENSANAG00000018241; ENSCANG00000036472; ENSCATG00000025001; ENSG00000132485; ENSGGOG00000023501; ENSMFAG00000003326; ENSMLEG00000036639; ENSMNEG00000042080; ENSNLEG00000009455; ENSPANG00000013398; ENSPPAG00000037049; ENSPTRG00000000856; ENSSBOG00000013268","","","",8199.6,8140.7,8033.3,7434.9,8154.6,6001,{"$f":"AVERAGE(S770:U770)/AVERAGE(V770:X770)","v":1.1289039160741994},{"$f":"LOG(Y770,2)","v":0.17492269983789435},{"$f":"TTEST(V770:X770,S770:U770,2,2)","v":0.2177389815900509},0.6620638126955627,{"$f":"AA770*7309/AE770","v":0.45263202970468774},0.34425471721332396,3516]
["O95219","sorting nexin-4 [OS=Homo sapiens]",11,5,6,5,450,51.9,5.99,13.91,"transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","SNX4","ENSG00000114520","Endocytosis","","",321.5,334.6,367.1,334.1,334.5,251.1,1.1125366967489398,0.1538529238044823,0.32631713659864225,{"$f":"-LOG10(AA771)","v":0.4863601185663761},0.5389947912767178,{"$f":"-LOG10(AC771)","v":0.2684154317162474},4425]
["O95229","ZW10 interactor [OS=Homo sapiens]",8,2,2,2,277,31.3,5.15,5.15,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","ZWINT","ENSG00000122952","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",166.8,171.9,191,325.7,411.9,405.6,0.46334849545136475,-1.1098304077984305,2.0519073874837087E-3,2.687842244930813,0.04837868095199493,1.3153459768811124,310]
["O95232-1","Luc7-like protein 3 [OS=Homo sapiens]",49,22,71,22,432,51.4,9.79,189.39,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity","LUC7L3","ENSCANG00000028098; ENSCATG00000034891; ENSG00000108848; ENSGGOG00000024399; ENSMLEG00000034172; ENSMMUG00000010117; ENSPPAG00000025115; ENSPTRG00000009409; ENSRROG00000039925","","","",7495.1,7221.2,7383.5,7671.2,8059.8,11482.6,0.8120866037569451,-0.300294505225358,0.23280917816409272,0.632999902254766,0.4622663089381564,0.3351077578174597,3681]
["O95235","kinesin-like protein KIF20A [OS=Homo sapiens]",19,14,24,14,890,100.2,6.92,75.44,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","KIF20A","ENSG00000112984","","COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Mitotic Telophase/Cytokinesis","",1561.9,1528.9,1541,1083.2,1061.5,1186.7,1.3903464009125295,0.4754443711629761,4.039815417158564E-4,3.3936384777460358,0.022035082749262646,1.6568853142268705,134]
["O95236-1","Apolipoprotein L3 [OS=Homo sapiens]",24,10,18,10,402,44.3,8.16,43.95,"protein metabolism;other metabolic processes;stress response;transport","non-structural extracellular;other cell component","transporter activity;other molecular function","APOL3","ENSG00000128284","","","",1259.1,1289.1,1275.6,1437.7,1525.3,1517.7,0.8533934429888187,-0.22871706918997858,1.720793198447676E-3,2.7642713191957218,0.04475899461727425,1.3491196772168288,281]
["O95239-1","Chromosome-associated kinesin KIF4A [OS=Homo sapiens]",32,33,76,33,1232,139.8,6.27,222.16,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","KIF4A","ENSG00000090889; ENSGGOG00000006631; ENSPTRG00000021996","","MHC class II antigen presentation; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","Retinoblastoma gene in cancer",6491.9,6685.6,6880.4,5325.5,5550,5923.6,1.193986582614545,0.25578662445512995,6.348461550271375E-3,2.197331506389587,0.08154816427229082,1.0885858109006852,569]
["O95243","Methyl-CpG-binding domain protein 4 [OS=Homo sapiens]",24,11,15,1,580,66,8.82,29.4,"DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus","nucleic acid binding activity;other molecular function","MBD4","ENSG00000129071","Base excision repair","Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Displacement of DNA glycosylase by APEX1","Base excision repair; DNA repair pathways, full network",1653.5,1790.6,1651.7,2233.3,2174.8,2735.7,0.71331784204485,-0.4873830350962547,0.02060319689658968,1.686065387066411,0.143828811955276,0.8421541068612806,1047]
["O95243-2","Isoform 2 of Methyl-CpG-binding domain protein 4 [OS=Homo sapiens]",24,11,15,1,574,65.3,8.84,29.64,"","","","MBD4","","","","",156.7,158.8,156.7,164.8,192.8,122.9,0.9827263267429761,-0.025138389432470133,0.8982912475629823,0.04658283181581218,0.9354054321752155,0.02900011234405237,7019]
["O95248-1","Myotubularin-related protein 5 [OS=Homo sapiens]",26,36,70,36,1867,208.2,6.9,212.66,"","","","","","","","",5761.5,5650.1,5753.6,5126.6,5074.6,8227.3,0.9314485715060912,-0.1024519796993905,0.7070463225441013,0.15055213221969516,0.800093136936807,0.09685945487887183,6459]
["O95249-1","Golgi SNAP receptor complex member 1 [OS=Homo sapiens]",24,7,11,7,250,28.6,9.42,33.73,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","GOSR1","ENSG00000108587","SNARE interactions in vesicular transport","Intra-Golgi traffic; COPI-mediated anterograde transport","",1582.1,1603.8,1638.3,1982.7,1958.6,1478.4,0.8901230695425945,-0.16792327617467512,0.2954104569996297,0.5295741355072904,0.5169152574120884,0.2865806488884386,4177]
["O95251-1","Histone acetyltransferase KAT7 [OS=Homo sapiens]",9,7,13,7,611,70.6,8.85,30.93,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","KAT7","ENSAMEG00000012243; ENSANAG00000032052; ENSCANG00000040077; ENSCATG00000030056; ENSCJAG00000007037; ENSDLEG00000005028; ENSECAG00000010150; ENSG00000136504; ENSGGOG00000007469; ENSMLEG00000043692; ENSMNEG00000044419; ENSPANG00000022824; ENSPCTG00005022544; ENSPPAG00000041097; ENSPPYG00000008925; ENSPTRG00000009383; ENSRFEG00010021504","","HATs acetylate histones","Androgen receptor signaling pathway; Androgen receptor signaling pathway",1475.9,1468.3,1407.2,1739,1705.1,1827.9,0.8253793626707131,-0.27687072844068805,0.00196601586697994,2.706412981461144,0.047424455352331286,1.3239976480794762,303]
["O95260","Arginyl-tRNA--protein transferase 1 [OS=Homo sapiens]",22,8,18,8,518,59.1,7.93,49.56,"protein metabolism;other metabolic processes","nucleus;other cell component","other molecular function","ATE1","ENSG00000107669","","","",928.8,852.2,906.6,944.3,990.5,965.2,0.9267586206896552,-0.10973446486087582,0.05503754864554289,1.2593409176762922,0.23239135935890987,0.6337800236677132,1731]
["O95263-4","Isoform 4 of High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [OS=Homo sapiens]",1,1,2,1,865,96.7,6.83,1.82,"","","","PDE8B","","","","",143,165.8,156.7,138.1,132.6,46.3,1.4684542586750786,0.5542983274193862,0.1794180919549201,0.7461337661970223,0.41315905296109356,0.38388272673187873,3174]
["O95271","Tankyrase-1 [OS=Homo sapiens]",1,1,1,1,1327,142,7.05,0,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","TNKS","ENSG00000173273","","Degradation of AXIN; Ub-specific processing proteases; Regulation of PTEN stability and activity; XAV939 stabilizes AXIN","NAD+ biosynthetic pathways; Regulation of Wnt / B-catenin signaling by small molecule compounds",57.3,74.3,55.7,44,56,77.3,1.056401579244219,0.07915836334435694,0.7847361126220651,0.10527636121565073,0.8556819703348759,0.06768761872540403,6703]
["O95273-1","Cyclin-D1-binding protein 1 [OS=Homo sapiens]",8,3,8,3,360,40.2,4.82,20.1,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","","CCNDBP1","ENSG00000166946","","","",539,582.1,577.8,509.4,526,410.2,1.1752213613724403,0.232932524344138,0.09434217975341572,1.0252940937046464,0.3045702260678955,0.5163125543369074,2264]
["O95292","Vesicle-associated membrane protein-associated protein B/C [OS=Homo sapiens]",44,10,36,9,243,27.2,7.3,130.67,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","VAPB","ENSG00000124164","Cholesterol metabolism; Amyotrophic lateral sclerosis; Pathways of neurodegeneration","RHOA GTPase cycle; Sphingolipid de novo biosynthesis; RHOC GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOD GTPase cycle","Ciliary landscape",5398.4,5079.3,5154.5,5028,5651.5,3906.3,1.0717410083780115,0.0999563133780078,0.5388098985270362,0.2685644344112216,0.6759631905825794,0.17007695281889715,5826]
["O95295","SNARE-associated protein Snapin [OS=Homo sapiens]",14,2,4,2,136,14.9,9.31,12.19,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SNAPIN","ENSG00000143553","","Golgi Associated Vesicle Biogenesis","",119.9,116.7,130.9,138.7,204.6,292,0.5784668660475366,-0.7896937691896991,0.1159572160978971,0.9357022197385181,0.3387415237648001,0.47013156321194627,2502]
["O95297-1","Myelin protein zero-like protein 1 [OS=Homo sapiens]",3,1,2,1,269,29.1,8.72,4.69,"cell-cell signaling;signal transduction","plasma membrane;other membranes","other molecular function","MPZL1","ENSG00000197965","Cell adhesion molecules","","",395.8,425.3,474.3,391.6,390,223.7,1.2885705759474786,0.3657715568180345,0.18361144516271896,0.7361002511516973,0.41690464513647496,0.37996326595333785,3219]
["O95298-1","NADH dehydrogenase [ubiquinone] 1 subunit C2 [OS=Homo sapiens]",30,5,22,5,119,14.2,8.98,49.67,"cell organization and biogenesis;other metabolic processes;transport","plasma membrane;other membranes;mitochondrion;other cytoplasmic organelle;other cell component","transporter activity","NDUFC2","ENSG00000151366; ENSGGOG00000041901","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Neutrophil degranulation; Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",2629.4,1990.8,2595.8,2414.3,3329.6,2422.1,0.8836639725691894,-0.17843022896976982,0.4379203495674382,0.35860487326070334,0.604373080624699,0.2186948878083739,5296]
["O95299","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [OS=Homo sapiens]",35,10,24,10,355,40.7,8.48,57.68,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;other cell component","transporter activity","NDUFA10","ENSG00000130414","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",2454.1,2280.1,2423.6,2313.7,2151,1836.9,1.135870255173289,0.18379805235305446,0.12958098156780556,0.8874587346247791,0.3543237539390538,0.4505997314973434,2673]
["O95319-1","CUGBP Elav-like family member 2 [OS=Homo sapiens]",17,9,36,8,508,54.3,8.76,79.13,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","CELF2","ENSANAG00000024646; ENSCATG00000032144; ENSG00000048740; ENSPANG00000023401; ENSPPYG00000002083; ENSSBOG00000028844","","","mRNA processing",4419.9,4856.7,4929.3,4932.1,4745.6,3931.1,1.0438760213979186,0.061950376720481405,0.5960086859765585,0.2247474109909692,0.7175469421516499,0.14414968197994513,6071]
["O95336","6-phosphogluconolactonase [OS=Homo sapiens]",38,6,21,6,258,27.5,6.05,60.85,"other metabolic processes","cytosol;other cell component","other molecular function","PGLS","ENSG00000130313","Pentose phosphate pathway; Metabolic pathways; Carbon metabolism","Pentose phosphate pathway","Pentose phosphate metabolism",1428.3,1394.8,1397.6,1278.8,1449.5,1581.1,0.9794170882257391,-0.030004727426077838,0.7542068580647839,0.12250952283712012,0.834215787771717,0.07872159526547294,6608]
["O95340","bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [OS=Homo sapiens]",29,15,34,13,614,69.5,8.03,114.36,"other metabolic processes;developmental processes","cytosol","kinase activity;other molecular function","PAPSS2","ENSG00000198682","Purine metabolism; Selenocompound metabolism; Sulfur metabolism; Metabolic pathways","Transport and synthesis of PAPS; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se; Defective PAPSS2 causes SEMD-PA","RANKL/RANK signaling pathway; Proteoglycan biosynthesis; Sulfation biotransformation reaction",3260.8,3153.6,3141.8,3110.3,3173.4,3454.9,0.9812704084776045,-0.027277340489238727,0.61754202660499,0.2093334813046333,0.7327296546194597,0.1350562315850858,6160]
["O95347-1","structural maintenance of chromosomes protein 2 [OS=Homo sapiens]",48,65,205,65,1197,135.6,8.43,553.65,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMC2; SMC2L1","ENSG00000136824","","Condensation of Prophase Chromosomes; Condensation of Prometaphase Chromosomes","Retinoblastoma gene in cancer",24617.1,24429.5,24681.4,25197.5,25235.8,21413.2,1.0261877753265642,0.03729474434222881,0.6473414233063987,0.18886660163680072,0.7548529774962457,0.12213762754938025,6268]
["O95352","Ubiquitin-like modifier-activating enzyme ATG7 [OS=Homo sapiens]",6,3,3,3,703,77.9,6.24,2.83,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;cytosol;cytoskeleton;other cell component","other molecular function","ATG7","ENSG00000197548","Autophagy; Autophagy; Ferroptosis; Neutrophil extracellular trap formation","Neutrophil degranulation; Antigen processing: Ubiquitination & Proteasome degradation; Signaling by BRAF and RAF1 fusions; Macroautophagy","Nanoparticle triggered autophagic cell death; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Senescence and autophagy in cancer",71.7,65.9,64.6,55.8,66.6,49.9,1.1735345327916427,0.2308602956780667,0.1361876977271908,0.86586212186894,0.36275360156269587,0.4403882670196812,2744]
["O95359","Transforming acidic coiled-coil-containing protein 2 [OS=Homo sapiens]",1,4,12,1,2948,309.2,4.79,28.04,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","TACC2","ENSG00000138162","","","",59,55.5,57.1,62.6,57,34,1.1171875,0.1598713367783894,0.5331797233021746,0.27312637505979287,0.6725941659674826,0.17224690404356288,5794]
["O95363","phenylalanine--tRNA ligase, mitochondrial [OS=Homo sapiens]",7,3,6,3,451,52.3,7.46,19.74,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","FARS2","ENSG00000145982","Aminoacyl-tRNA biosynthesis","Mitochondrial tRNA aminoacylation","",974.7,945,974.7,986,922.1,1049,0.9787967941564372,-0.030918718707272794,0.6111095663051878,0.2138809177839583,0.7285271277319553,0.13755427202721954,6131]
["O95365","Zinc finger and BTB domain-containing protein 7A [OS=Homo sapiens]",11,3,4,3,584,61.4,5.19,20.38,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB7A","ENSG00000178951","","","IL-18 signaling pathway",89.4,96.4,105.3,110.5,105,441.6,0.44300715264038965,-1.1745981026634689,0.33492679166000516,0.4750501107321152,0.5439955378317728,0.264404662623486,4500]
["O95372","acyl-protein thioesterase 2 [OS=Homo sapiens]",29,5,22,5,231,24.7,7.23,67.04,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes","cytosol;ER/Golgi;other cell component","other molecular function","LYPLA2","ENSG00000011009","Glycerophospholipid metabolism","L1CAM interactions","",2791.9,2676,2957,2578.5,2839.4,3622.7,0.9318961130898392,-0.10175896134243471,0.5610629606479256,0.2509884009047711,0.6922365258905618,0.15974548886996898,5924]
["O95373","Importin-7 [OS=Homo sapiens]",36,27,146,26,1038,119.4,4.82,481.3,"stress response;transport;signal transduction;other biological processes","cytosol;nucleus","transporter activity;enzyme regulator activity;other molecular function","IPO7","ENSG00000205339","Nucleocytoplasmic transport","","",13969.7,14532.1,14568.2,13352.1,12832.8,13001.7,1.0991002026202832,0.13632291971159347,0.006322741648076782,2.1990945634195693,0.08150426579504974,1.088819660428503,567]
["O95376","E3 ubiquitin-protein ligase ARIH2 [OS=Homo sapiens]",25,9,23,9,493,57.8,5.63,62.16,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","other molecular function","ARIH2","ENSG00000177479","","Antigen processing: Ubiquitination & Proteasome degradation","Modulators of TCR signaling and T cell activation",1273.2,1322.3,1347.4,1311.3,1263.7,1596.6,0.945176910537923,-0.08134370833830379,0.5125722247537206,0.2902449310487932,0.6571461832529282,0.18233801016895218,5701]
["O95379","Tumor necrosis factor alpha-induced protein 8 [OS=Homo sapiens]",24,4,10,4,198,23,7.93,27.88,"other biological processes","nucleus;other cell component","enzyme regulator activity","TNFAIP8","ENSG00000145779","","PI Metabolism","",209.8,224.9,227.1,246.4,301.5,73.8,1.0645005629724948,0.09017671277509344,0.8554259660083432,0.06781757109699281,0.9058690793327993,0.04293456416848788,6902]
["O95391","Pre-mRNA-splicing factor SLU7 [OS=Homo sapiens]",16,8,13,8,586,68.3,7.14,34.85,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SLU7","ENSG00000164609","Spliceosome","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway","",627.7,613.8,620.4,971.9,921.8,1091.9,0.623626741693462,-0.6812453014229358,0.001779959470428159,2.749589886438184,0.045488544648109835,1.342097957683254,286]
["O95394","phosphoacetylglucosamine mutase [OS=Homo sapiens]",23,14,33,14,542,59.8,6.25,91.25,"protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol","other molecular function","PGM3","ENSG00000013375","Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars","Synthesis of UDP-N-acetyl-glucosamine","Glucuronidation",4887.8,5211.1,5436.2,5312,4315.6,2833,1.2467377172848821,0.318157989809141,0.2370346060314088,0.6251882442374566,0.4662233410881504,0.33140598767508783,3716]
["O95396","Adenylyltransferase and sulfurtransferase MOCS3 [OS=Homo sapiens]",14,6,11,6,460,49.6,6.21,33.72,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;other cell component","other molecular function","MOCS3","ENSG00000124217","Sulfur relay system","Molybdenum cofactor biosynthesis","",1154.5,1085.9,1099.1,1097.1,1073.9,956,1.0679565078349857,0.0948528949576583,0.21775315252501515,0.6620355487689452,0.45253278129239,0.34434995520191486,3517]
["O95400","CD2 antigen cytoplasmic tail-binding protein 2 [OS=Homo sapiens]",50,10,33,10,341,37.6,4.61,102.7,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","CD2BP2","ENSG00000169217","","mRNA Splicing - Major Pathway","mRNA processing; Ciliary landscape",1918.1,1941.1,1841.4,2214,2251.9,2548.7,0.8126764177572493,-0.29924706414084706,0.01638908819604328,1.785445207652334,0.13020418002704381,0.8853750731139163,920]
["O95425","Supervillin [OS=Homo sapiens]",1,2,2,2,2214,247.6,6.98,2.04,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","SVIL","ENSG00000197321","","","",211.9,255.6,247.7,238.3,246.5,64,1.3032069970845483,0.38206625501050573,0.41472530738592045,0.382239462290413,0.5906522353241801,0.22866814810933095,5132]
["O95427","GPI ethanolamine phosphate transferase 1 [OS=Homo sapiens]",2,2,2,2,931,105.7,8.65,5.83,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;ER/Golgi","other molecular function","PIGN","ENSG00000197563","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways","Synthesis of glycosylphosphatidylinositol (GPI)","",253.8,260.3,241.6,227.5,234.3,316.6,0.9708376156217882,-0.04269808732571434,0.8080278218328837,0.0925736854376934,0.8728754581401931,0.059047717005682246,6766]
["O95433","activator of 90 kDa heat shock protein ATPase homolog 1 [OS=Homo sapiens]",71,19,101,19,338,38.3,5.53,313.06,"other biological processes","cytosol;ER/Golgi","other molecular function","AHSA1","ENSG00000100591","","","T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection",11823.5,12324.8,12432.3,12479.5,11762.3,13363.3,0.9727563548561232,-0.03984959477073482,0.531775811313693,0.2742714211449233,0.6716345956267119,0.17286694162449737,5787]
["O95453","poly(A)-specific ribonuclease PARN [OS=Homo sapiens]",26,16,30,16,639,73.4,6.2,64.2,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PARN","ENSG00000140694; ENSG00000274829","RNA degradation","Deadenylation of mRNA; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA","Lung fibrosis",2286.1,2329.3,2276.1,2446.3,2346.3,2285.3,0.9736645050085476,-0.038503345515629346,0.27927751017326036,0.5539640360172592,0.5053823525269522,0.2963799273032745,4039]
["O95456","Proteasome assembly chaperone 1 [OS=Homo sapiens]",48,9,19,9,288,32.8,7.17,59.26,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes","cytosol;ER/Golgi;nucleus;other cell component","other molecular function","PSMG1","ENSG00000183527","","","",1489.1,1612.4,1561.1,1557.1,1473.4,791.7,1.2198733713568104,0.28673139697086686,0.3166782329070618,0.4993817871277191,0.5339333804654475,0.27251292705597524,4335]
["O95461-1","LARGE xylosyl- and glucuronyltransferase 1 [OS=Homo sapiens]",5,4,6,3,756,88,7.84,7.11,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","LARGE; LARGE1","ENSG00000133424; ENSPTRG00000014294","Mannose type O-glycan biosynthesis; Metabolic pathways","Defective LARGE causes MDDGA6 and MDDGB6; O-linked glycosylation","",132.9,109.9,115.6,115.9,116.4,174,0.8821068176224464,-0.18097472717348403,0.47929174084927506,0.31940005470211913,0.6325647045625409,0.19889504422770182,5538]
["O95466-2","Isoform 2 of Formin-like protein 1 [OS=Homo sapiens]",42,47,196,5,1104,122.3,5.83,583.57,"","","","FMNL1","","","","",23373.6,23469.1,23539.5,21633.8,22308.1,22747.6,1.0553715352491773,0.07775097779598124,0.01979067102860537,1.7035394802210975,0.14195290927191037,0.8478557023435508,1019]
["O95470","sphingosine-1-phosphate lyase 1 [OS=Homo sapiens]",5,3,8,3,568,63.5,9.16,14.54,"other metabolic processes;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","SGPL1","ENSG00000166224","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway","Sphingolipid de novo biosynthesis","Sphingolipid pathway; Kennedy pathway from sphingolipids; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway",622.9,623.6,641.5,597.9,558.2,338.6,1.263129725028434,0.3370028133490698,0.18028621111321325,0.7440374882883857,0.4139842654811422,0.3830161650254158,3183]
["O95476","CTD nuclear envelope phosphatase 1 [OS=Homo sapiens]",4,1,1,1,244,28.4,9.76,3.48,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","CTDNEP1","ENSG00000175826; ENSG00000288307","","Depolymerisation of the Nuclear Lamina","Development of ureteric collection system",140,155.3,148.7,144.7,164.4,125,1.022805805114029,0.032532253984587436,0.8002649956934144,0.09676617911961963,0.8676957207421994,0.061632544374437985,6741]
["O95478","Ribosome biogenesis protein NSA2 homolog [OS=Homo sapiens]",26,6,10,6,260,30,10.27,28.21,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","NSA2","ENSG00000164346","","","",879.9,926.2,858.6,2118.4,1893.5,2250.7,0.4254942036853703,-1.2327886160227273,3.4983358207700554E-4,3.4561385030028653,0.021668929249159606,1.6641625484250178,118]
["O95479","GDH/6PGL endoplasmic bifunctional protein [OS=Homo sapiens]",3,2,2,2,791,88.8,7.3,6.86,"other metabolic processes;other biological processes","mitochondrion;ER/Golgi","other molecular function","H6PD","ENSG00000049239","Pentose phosphate pathway; Metabolic pathways; Carbon metabolism","","Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism",104.9,101.9,95.8,78.6,87.6,236.5,0.7514278619319594,-0.4122934847290166,0.5506610759051169,0.2591156210256435,0.6848361075022119,0.16441334985606934,5877]
["O95486-1","Protein transport protein Sec24A [OS=Homo sapiens]",9,9,26,9,1093,119.7,7.66,77.11,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi","other molecular function","SEC24A","ENSG00000113615","Protein processing in endoplasmic reticulum; Pathogenic Escherichia coli infection","MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Sterol regulatory element-binding proteins (SREBP) signaling",2036.8,2046.5,2038,2292.8,2132.7,2255.6,0.9162114023139902,-0.12624757748059381,0.018305590516850413,1.7374162567265616,0.1368052771857461,0.86389714963019,978]
["O95487-1","Protein transport protein Sec24B [OS=Homo sapiens]",13,13,27,13,1268,137.3,6.67,85.07,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","SEC24B","ENSG00000138802","Protein processing in endoplasmic reticulum; Pathogenic Escherichia coli infection","COPII-mediated vesicle transport; MHC class II antigen presentation; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Sterol regulatory element-binding proteins (SREBP) signaling",2261.9,2279.3,2123.3,2329.4,2196.8,2879.7,0.8998906277427458,-0.15217842722468486,0.31405632231494235,0.5029924593245328,0.532337119619646,0.27381324961924214,4312]
["O95503","Chromobox protein homolog 6 [OS=Homo sapiens]",2,1,1,1,412,43.9,10.01,2.47,"cell organization and biogenesis;other biological processes","nucleus;other cell component","","CBX6","ENSG00000183741","","Regulation of PTEN gene transcription; Oxidative Stress Induced Senescence; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","",59.9,57.6,64.8,250.5,265.5,195.1,0.2563633806778231,-1.9637378948945146,1.2089855722929876E-3,2.917578881861254,0.03760202360804019,1.4247887822490175,235]
["O95544","NAD kinase [OS=Homo sapiens]",7,2,3,2,446,49.2,6.47,11.27,"other metabolic processes;other biological processes","cytosol","kinase activity;other molecular function","NADK","ENSG00000008130","Nicotinate and nicotinamide metabolism; Metabolic pathways; Biosynthesis of cofactors","Nicotinate metabolism","NAD+ metabolism",215.3,205.8,230.4,266,220.1,432.5,0.7092314391465273,-0.4956716047654472,0.24214952248993424,0.6159163830295462,0.47209145368869815,0.325973861567124,3749]
["O95551-1","Tyrosyl-DNA phosphodiesterase 2 [OS=Homo sapiens]",21,5,10,5,362,40.9,5.1,40.15,"DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TDP2","ENSG00000111802","","Nonhomologous End-Joining (NHEJ)","Oxidative damage response",982.5,759.6,693.6,1262.3,1310.1,1721.3,0.5672729813447609,-0.8178849433907689,0.021860114478784404,1.6603475680325108,0.14739444347364872,0.831518888350906,1084]
["O95562","Vesicle transport protein SFT2B [OS=Homo sapiens]",17,2,2,2,160,17.8,9.13,7.37,"transport","other membranes","","SFT2D2","ENSG00000213064","","","TYROBP causal network in microglia",180.7,189.3,195.2,210.4,178.2,136.5,1.0763664063987812,0.10616927000570041,0.5729615576857983,0.2418745156329487,0.7021757252054828,0.15355418852993272,5964]
["O95563","Mitochondrial pyruvate carrier 2 [OS=Homo sapiens]",28,4,16,4,127,14.3,10.43,39.48,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MPC2","ENSG00000143158","Diabetic cardiomyopathy","Pyruvate metabolism","Glycolysis and gluconeogenesis",2265.1,2145.8,2417.7,1886.3,2199,1261.4,1.2771616137056498,0.352941097114965,0.15992024846817043,0.7960965441258604,0.3914457789865565,0.407328385630894,2986]
["O95568","histidine protein methyltransferase 1 homolog [OS=Homo sapiens]",8,2,3,2,372,42.1,6.76,10.13,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","METTL18","ENSG00000171806","","","",128.8,123.4,127.9,151.2,167,193.2,0.7432538130621823,-0.4280731353796831,0.02399820690133755,1.6198212067028346,0.15305662673811185,0.8151478624502329,1146]
["O95571","Persulfide dioxygenase ETHE1, mitochondrial [OS=Homo sapiens]",20,4,16,4,254,27.9,6.83,64.11,"other metabolic processes","mitochondrion;nucleus;other cell component","other molecular function","ETHE1","ENSG00000105755","Sulfur metabolism; Metabolic pathways","Sulfide oxidation to sulfate","",2419.4,2580.4,2407.5,2091.7,2255.7,2730.3,1.0465688005990648,0.06566715633364045,0.6110235887839227,0.21394202334018877,0.7287812353821297,0.13740281808076338,6128]
["O95573","long-chain-fatty-acid--CoA ligase 3 [OS=Homo sapiens]",27,15,45,12,720,80.4,8.38,138.07,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ACSL3","ENSG00000123983","Fatty acid biosynthesis; Fatty acid degradation; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; Peroxisome; Ferroptosis; Thermogenesis; Adipocytokine signaling pathway","Synthesis of very long-chain fatty acyl-CoAs; Intracellular metabolism of fatty acids regulates insulin secretion","Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Ciliary landscape; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters",4282.5,4176.6,4153.1,3863.6,3917.7,4242.2,1.0489624485382791,0.06896303227429089,0.19079179655226397,0.7194403025285482,0.42489251706291814,0.37172091736164964,3282]
["O95602","DNA-directed RNA polymerase I subunit RPA1 [OS=Homo sapiens]",21,29,61,28,1720,194.7,7.03,192.23,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POLR1A","ENSG00000068654","RNA polymerase","B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","Pyrimidine metabolism; Eukaryotic transcription initiation",4403.7,4356.1,4343.3,4977.8,4693.8,5136.2,0.8848782398465673,-0.1764491423523708,0.012183730718311098,1.914219708231102,0.11505282664100235,0.9391027070300216,774]
["O95613","Pericentrin [OS=Homo sapiens]",23,67,104,67,3336,377.8,5.55,318.42,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton","other molecular function","PCNT","ENSG00000160299","","Late endosomal microautophagy; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Chaperone Mediated Autophagy","",8917.5,8792.8,8843.5,10737.7,10715.2,9884,0.8473652467219157,-0.23894413471294176,0.004897974066768812,2.3099835186578175,0.07291098259473167,1.137207048896813,491]
["O95619","YEATS domain-containing protein 4 [OS=Homo sapiens]",22,5,8,5,227,26.5,8.41,21.32,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","other membranes;nucleus","cytoskeletal activity;other molecular function","YEATS4","ENSG00000127337","","HATs acetylate histones; Activation of the TFAP2 (AP-2) family of transcription factors","",813.7,773.2,766.7,1176.8,1013.7,851.9,0.7735997896397582,-0.37034069237576095,0.07288413581518435,1.1373669912662585,0.2671565439684967,0.5732341833579225,1994]
["O95620","tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like [OS=Homo sapiens]",7,1,1,1,317,35.8,7.33,4.6,"RNA metabolism OR transcription;other metabolic processes","","other molecular function","DUS4L","ENSG00000105865; ENSG00000284103","","","",9.8,8.9,15.3,11.4,11.8,26.7,0.6813627254509017,-0.553505069199559,0.38331079839154464,0.41644894590139203,0.5711760704268705,0.2432299957333864,4905]
["O95625","Zinc finger and BTB domain-containing protein 11 [OS=Homo sapiens]",3,3,4,3,1053,119.3,8.66,12.07,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZBTB11","ENSG00000066422","","","",423.1,409.2,406.4,469.2,517.3,587.7,0.7868758734595348,-0.3457920206132429,0.03246205780584913,1.4886239532282592,0.1782608418504518,0.7489440468189613,1331]
["O95628-6","Isoform 6 of CCR4-NOT transcription complex subunit 4 [OS=Homo sapiens]",14,7,14,7,767,84.7,7.3,39.71,"","","","CNOT4","","","","",922.1,899,891,1032.5,979.5,1323.2,0.8131746222115614,-0.29836290304562746,0.12484049931028138,0.9036445030052125,0.3501378393932642,0.4557609524978055,2606]
["O95630","STAM-binding protein [OS=Homo sapiens]",21,10,22,10,424,48,6.29,53.17,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle","other molecular function","STAMBP","ENSG00000124356","Endocytosis","Metalloprotease DUBs","EGF/EGFR signaling pathway",3667.1,3356.5,3301.2,4026.2,3963,4309.2,{"$f":"AVERAGE(S834:U834)/AVERAGE(V834:X834)","v":0.8395238404995773},{"$f":"LOG(Y834,2)","v":-0.2523568000024299},{"$f":"TTEST(V834:X834,S834:U834,2,2)","v":0.013472692820106469},1.870545592099427,{"$f":"AA834*7309/AE834","v":0.1202343245691797},0.9199715319758724,819]
["O95639","Cleavage and polyadenylation specificity factor subunit 4 [OS=Homo sapiens]",18,5,10,5,269,30.2,8.31,21.81,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CPSF4","ENSG00000160917","mRNA surveillance pathway; Influenza A","mRNA Splicing - Major Pathway; Transport of Mature mRNA Derived from an Intronless Transcript; tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Inhibition of Host mRNA Processing and RNA Silencing","mRNA processing",1071.1,1064.5,1131.3,1235.5,1197.8,788.6,1.0139669139327723,0.020010577505083053,0.9224090554671271,{"$f":"-LOG10(AA835)","v":0.03507644213996181},0.9514377344636229,{"$f":"-LOG10(AC835)","v":0.02161962825314731},7086]
["O95671-1","N-acetylserotonin O-methyltransferase-like protein [OS=Homo sapiens]",24,12,24,12,621,68.8,6.07,76.91,"other metabolic processes","cytosol","other molecular function","ASMTL","ENSG00000169093","Pyrimidine metabolism","","",2622.7,2659.8,2585.8,2241,2038.3,2061.1,1.2409784871616933,0.31147810601286796,1.6595034142359959E-3,2.780021849743881,0.043946777009604684,1.357072969925126,276]
["O95674-1","phosphatidate cytidylyltransferase 2 [OS=Homo sapiens]",31,9,25,8,445,51.4,7.09,87.87,"cell organization and biogenesis;other metabolic processes","other membranes;mitochondrion;ER/Golgi","other molecular function","CDS2","ENSG00000101290","Glycerophospholipid metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of PG","",2045.2,1981.3,1962.4,1898.8,1987.2,2023.5,1.0134359928927998,0.01925497321310716,0.5856984535794003,0.232325922638968,0.7107537767245288,0.1482808239255755,6023]
["O95684","FGFR1 oncogene partner [OS=Homo sapiens]",34,7,10,7,399,43,4.81,32.64,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","CEP43","ENSG00000213066","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease","Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome",418.3,640.2,467.6,431.5,506.1,464.4,1.0885164051355207,0.1223631506857995,0.5896459614231879,0.22940867166443255,0.7128220860142377,0.14701885262225783,6046]
["O95696","Bromodomain-containing protein 1 [OS=Homo sapiens]",5,4,5,4,1058,119.4,8.6,10.81,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","other molecular function","BRD1","ENSG00000100425","","HATs acetylate histones; Regulation of TP53 Activity through Acetylation","Pathways affected in adenoid cystic carcinoma",405.2,414.5,394.5,396.5,423.5,528.8,0.9002075919335707,-0.15167036309132803,0.3329102823575621,0.4776727908986434,0.5428918459954086,0.26528668121371285,4482]
["O95707","Ribonuclease P protein subunit p29 [OS=Homo sapiens]",12,2,3,2,220,25.4,10.07,9.23,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POP4","ENSG00000105171","Ribosome biogenesis in eukaryotes","tRNA processing in the nucleus","",153.1,152.9,139,164.1,156.1,164.4,0.9182831200990509,-0.12298906871022379,0.07089654529029994,1.1493749269877964,0.2642441863981654,0.5779945587716075,1961]
["O95714","E3 ubiquitin-protein ligase HERC2 [OS=Homo sapiens]",4,14,22,14,4834,526.9,6.28,62.99,"protein metabolism;DNA metabolism;other metabolic processes;stress response;transport","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","HERC2","ENSG00000128731","Ubiquitin mediated proteolysis","SUMOylation of DNA damage response and repair proteins; Antigen processing: Ubiquitination & Proteasome degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)","Prader-Willi and Angelman syndrome",1259.5,1306.5,1291.7,1443.4,1392.7,1602.6,0.8691058192714081,-0.2023962496730719,0.04027649224501986,1.3949483599895127,0.19730622105821058,0.7048592212421898,1492]
["O95716","ras-related protein Rab-3D [OS=Homo sapiens]",31,7,25,4,219,24.3,4.93,56.46,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB3D","ENSG00000105514","Pancreatic secretion","Neutrophil degranulation; RAB geranylgeranylation","",1041.1,1097.4,1065.9,1021.7,1067.2,958.1,1.0516573679028554,0.07266474822066578,0.21440217394873465,0.668770815391801,0.4499183144964977,0.34686632796606437,3483]
["O95721","Synaptosomal-associated protein 29 [OS=Homo sapiens]",22,6,7,6,258,29,5.81,17.87,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","SNAP29","ENSG00000099940","SNARE interactions in vesicular transport; Autophagy","Intra-Golgi traffic; Neutrophil degranulation","Ciliary landscape; 22q11.2 copy number variation syndrome",989,982.8,1044.9,1131.8,1162.4,1261.6,0.8483885482873053,-0.23720294766413003,0.014901042678286212,1.8267833414143904,0.12461295301555368,0.9044368121648205,874]
["O95747","Serine/threonine-protein kinase OSR1 [OS=Homo sapiens]",31,13,59,11,527,58,6.43,200.91,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol","kinase activity;other molecular function","OXSR1","ENSG00000172939","","","",4701.4,4822.9,4761.5,4489.1,4383.1,4095.8,1.101619370758791,0.13962583300594308,0.02311443290502902,1.6361167571788655,0.15043935004706777,0.8226385515563502,1123]
["O95749","geranylgeranyl pyrophosphate synthase [OS=Homo sapiens]",12,4,7,4,300,34.8,6.14,18.08,"other metabolic processes","cytosol","other molecular function","GGPS1","ENSG00000152904","Terpenoid backbone biosynthesis; Metabolic pathways","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways",987.1,1011.6,1030.5,997.2,1042.3,557.9,1.166243166243166,0.22186862743846592,0.40568386275167495,0.3918122672704997,0.5849562739893455,0.23287659660992854,5069]
["O95757","Heat shock 70 kDa protein 4L [OS=Homo sapiens]",56,41,192,36,839,94.5,5.88,590.57,"stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","HSPA4L","ENSG00000164070","Protein processing in endoplasmic reticulum","Regulation of HSF1-mediated heat shock response","",17547.5,17433.7,17424.4,18043.3,18086.7,13930.3,1.0468494995035986,0.06605404787840345,0.6010395165181552,0.22109697351872762,0.7213461126816415,0.14185630426763,6090]
["O95758-1","Isoform 1 of Polypyrimidine tract-binding protein 3 [OS=Homo sapiens]",17,8,57,3,521,56.5,9.22,133.39,"","","","PTBP3","","","","",1082.4,1196.9,1151.4,1111,1324.3,3166,0.6124828164890294,-0.7072587257334847,0.33012980688118954,0.4813152621597947,0.5412558901961899,0.26659736442004056,4458]
["O95772-1","STARD3 N-terminal-like protein [OS=Homo sapiens]",7,2,3,2,234,26.6,4.81,4.26,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","STARD3NL","ENSCANG00000042172; ENSCATG00000036966; ENSCSAG00000015104; ENSG00000010270; ENSGGOG00000013471; ENSMFAG00000043802; ENSMLEG00000030425; ENSMMUG00000023659; ENSMNEG00000034363; ENSPANG00000016262; ENSPPAG00000039214; ENSPTRG00000019094; ENSRBIG00000036179; ENSRROG00000026971","","Pregnenolone biosynthesis","",583.9,616.5,591.7,562,544.8,501.1,1.1145593631444741,0.15647345879898192,0.040829380821846804,1.3890272061091904,0.19815534158491252,0.7029942160898993,1506]
["O95777","U6 snRNA-associated Sm-like protein LSm8 [OS=Homo sapiens]",59,4,23,4,96,10.4,4.48,78.7,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","LSM8","ENSG00000128534","RNA degradation; Spliceosome","mRNA Splicing - Major Pathway","",863.3,913.4,988.9,949.3,944.4,574.8,1.1203564917966375,0.16395786363393947,0.48637653233663586,0.31302738793469903,0.637998218745239,0.1951805338026519,5572]
["O95782","AP-2 complex subunit alpha-1 [OS=Homo sapiens]",38,32,95,22,977,107.5,7.03,261.06,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","AP2A1","ENSG00000196961","Endocytosis; Synaptic vesicle cycle; Endocrine and other factor-regulated calcium reabsorption; Huntington disease","MHC class II antigen presentation; Recycling pathway of L1; Potential therapeutics for SARS; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Trafficking of GluR2-containing AMPA receptors; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation","Synaptic vesicle pathway; VEGFA-VEGFR2 signaling pathway; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; mBDNF and proBDNF regulation of GABA neurotransmission",10849.9,11375.6,11521.7,10116.4,10056.4,11456.9,1.0669465723671108,0.0934879346338667,0.2313628239056221,0.635706423559385,0.46152589517636244,0.3358039266712248,3664]
["O95785-3","Isoform 3 of Protein Wiz [OS=Homo sapiens]",14,8,13,8,965,102.9,9.52,28.55,"","","","WIZ","","","","",494.9,485.2,469.4,553.4,560.3,717.5,0.7915574486675405,-0.33723403460692725,0.07835897439943075,1.1059112568986225,0.27748340304527097,0.5567629879698234,2064]
["O95793","double-stranded RNA-binding protein Staufen homolog 1 [OS=Homo sapiens]",12,6,9,6,577,63.1,9.44,22.2,"cell organization and biogenesis;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","nucleic acid binding activity;other molecular function","STAU1","ENSG00000124214","","","",665.7,652.6,624.3,764.5,765.9,685.8,0.8765454381373524,-0.19009921590902168,0.035242117891082,1.452938000351588,0.18412054300637481,0.7348977529594425,1399]
["O95801","Tetratricopeptide repeat protein 4 [OS=Homo sapiens]",36,10,23,10,387,44.7,5.6,68.81,"stress response","nucleus;other cell component","other molecular function","TTC4","ENSG00000243725","","","",2292.8,2228.2,2368.6,3270.8,3444.9,2597.3,0.739783098894019,-0.43482575390140865,0.0366548798231977,1.4358682000347918,0.18735001162779857,0.7273462756158806,1430]
["O95816","BAG family molecular chaperone regulator 2 [OS=Homo sapiens]",33,8,15,8,211,23.8,6.7,43.88,"protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","BAG2","ENSG00000112208","Protein processing in endoplasmic reticulum","Regulation of HSF1-mediated heat shock response","Malignant pleural mesothelioma",1380.5,1440.5,1509.8,1806.5,1986.7,1400.3,0.8338885144892655,-0.2620735773380424,0.18032781757116337,0.7439372733563966,0.4138197860683306,0.3831887481437929,3185]
["O95817","BAG family molecular chaperone regulator 3 [OS=Homo sapiens]",4,2,3,2,575,61.6,6.95,7.24,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","BAG3","ENSG00000151929","","Regulation of HSF1-mediated heat shock response","",174.4,171,156.9,142.6,86.3,252.2,1.0440656828102266,0.06221247558960777,0.8923069205418959,0.049485738705696884,0.930765132330629,0.03115989431529937,7007]
["O95819","Mitogen-activated protein kinase kinase kinase kinase 4 [OS=Homo sapiens]",7,7,7,4,1239,142,7.46,21.82,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","other cell component","cytoskeletal activity;kinase activity;other molecular function","MAP4K4","ENSG00000071054","MAPK signaling pathway","Oxidative Stress Induced Senescence","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Insulin signaling; Malignant pleural mesothelioma",236.8,242.1,256.5,234.4,248,323.2,0.9128599801390269,-0.13153450680348822,0.45381583923824154,0.34312035028951454,0.6137934805685247,0.21197772875553458,5404]
["O95822","Malonyl-CoA decarboxylase, mitochondrial [OS=Homo sapiens]",18,6,6,6,493,55,8.95,22.43,"other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","MLYCD","ENSG00000103150","beta-Alanine metabolism; Propanoate metabolism; Metabolic pathways; Peroxisome; AMPK signaling pathway; Alcoholic liver disease","","",500.7,497,492,450,466.9,891.2,0.8239035451579007,-0.27945264469673314,0.5029816683851283,0.2984478429048283,0.6491776468703695,0.18763644264738444,5663]
["O95825-1","Quinone oxidoreductase-like protein 1 [OS=Homo sapiens]",11,2,3,2,349,38.7,5.78,10.21,"other metabolic processes","","other molecular function","CRYZL1","ENSG00000205758","","","",244.4,250.1,272.3,236.9,234,141.4,1.2523272905438512,0.3246116539142754,0.1881813187243966,0.7254234923731865,0.42229575024765575,0.37438328905408663,3257]
["O95831-1","Apoptosis-inducing factor 1, mitochondrial [OS=Homo sapiens]",47,23,87,23,613,66.9,8.95,288.87,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","AIFM1","ENSG00000156709","Apoptosis; Necroptosis","","Apoptosis modulation and signaling; Nanomaterial induced apoptosis; Apoptosis modulation by HSP70",9724.5,9838.8,9890.4,9088.5,8936.1,7357.7,1.160403115556904,0.2146260741339503,0.07095600425438987,1.1490108489137805,0.26406183049660675,0.5782943704807383,1964]
["O95834-3","Isoform 3 of Echinoderm microtubule-associated protein-like 2 [OS=Homo sapiens]",14,12,29,12,850,92,7.06,75.05,"","","","EML2","","","","",3599.4,3537.6,3603.6,3489,3410.4,3541.9,1.0286650129773114,0.04077324190231699,0.08477685502508456,1.0717226985319595,0.2895486137281977,0.5382785099971774,2140]
["O95835","Serine/threonine-protein kinase LATS1 [OS=Homo sapiens]",1,1,1,1,1130,126.8,8.7,3.38,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","LATS1","ENSG00000131023","Hippo signaling pathway; Hippo signaling pathway","Signaling by Hippo","Mesodermal commitment pathway; Transcription co-factors SKI and SKIL protein partners; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Overview of leukocyte-intrinsic Hippo pathway functions; Malignant pleural mesothelioma",24.6,20.6,24.8,27.8,21.3,48.6,0.7164790174002046,-0.4810036401360567,0.3306539913690596,0.4806262305009173,0.5413866538791345,0.26649245454646664,4464]
["O95841","Angiopoietin-related protein 1 [OS=Homo sapiens]",2,1,1,1,491,56.7,8.21,0,"developmental processes;signal transduction","non-structural extracellular;extracellular matrix","signal transduction activity or receptor binding","ANGPTL1","ENSG00000116194","","","RAC1/PAK1/p38/MMP2 pathway",49.2,49.9,51,54.7,48.9,58,0.9288366336633663,-0.10650322113110634,0.23024329375467387,0.6378130105459003,0.46105431069942776,0.3362479131184021,3650]
["O95848","uridine diphosphate glucose pyrophosphatase [OS=Homo sapiens]",7,1,1,1,222,24.1,5.05,3.49,"protein metabolism;other metabolic processes","cytosol","other molecular function","NUDT14","ENSG00000183828","","Synthesis of dolichyl-phosphate-glucose","",41.4,37.5,27.6,42,36.2,57.5,0.78481945467944,-0.34956729030565337,0.267858716321131,0.5720942167968961,0.4951389371753026,0.3052729198905767,3954]
["O95861-1","3'(2'),5'-bisphosphate nucleotidase 1 [OS=Homo sapiens]",60,14,59,13,308,33.4,5.69,154.82,"other metabolic processes;developmental processes","cytosol","other molecular function","BPNT1; HEL20","ENSG00000162813; ENSPTRG00000001996","Sulfur metabolism; Metabolic pathways","Cytosolic sulfonation of small molecules","",6270.6,6594.3,6652.4,5863,5608.1,4592.2,1.2150243100732727,0.2809851794041371,0.047041197050600204,1.3275216353618582,0.21515901704808316,0.6672404484558578,1598]
["O95865","N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 [OS=Homo sapiens]",53,12,36,11,285,29.6,6.01,135.24,"other metabolic processes;signal transduction;other biological processes","cytosol;mitochondrion","other molecular function","DDAH2","ENSG00000206395; ENSG00000213722; ENSG00000225635; ENSG00000226634; ENSG00000227317; ENSG00000228128; ENSG00000233076","","eNOS activation","Nitric oxide metabolism in cystic fibrosis",3764.6,3766.9,3640.6,3466.9,3500.3,5286.7,0.9117179020556719,-0.133340590959643,0.5817789902496205,0.2352419664567987,0.7081136785569486,0.1498970163117506,6005]
["O95870-1","Protein ABHD16A [OS=Homo sapiens]",26,11,30,11,558,63.2,8.13,82.31,"other metabolic processes","other membranes","other molecular function","ABHD16A","ENSG00000204427; ENSG00000206403; ENSG00000224552; ENSG00000230475; ENSG00000231488; ENSG00000235676; ENSG00000236063; ENSGGOG00000009970","","","IL-18 signaling pathway",1950.6,1922,2038.6,1722.3,1820.7,2555.7,0.9692557430272025,-0.0450507166392343,0.8253070685430902,0.08338443525402131,0.8851312346267713,0.05299233354074068,6815]
["O95873","Uncharacterized protein C6orf47 [OS=Homo sapiens]",10,3,5,3,294,31.7,6.37,5.67,"","","","C6orf47","ENSG00000203623; ENSG00000204439; ENSG00000226103; ENSG00000226531; ENSG00000228177; ENSG00000228435; ENSG00000235360","","","",566.9,600.8,593.6,644.5,723.6,993.3,0.7458710934191581,-0.42300177935932964,0.13242089720338793,0.8780434739297013,0.3582029376978395,0.44587085673174015,2702]
["O95881","Thioredoxin domain-containing protein 12 [OS=Homo sapiens]",30,5,11,5,172,19.2,5.4,26.41,"other biological processes","ER/Golgi","other molecular function","TXNDC12","ENSG00000117862","Glutathione metabolism; Metabolic pathways","","",1448,1483.7,1586.3,1593.5,1638,1454.6,0.9641279528819273,-0.05270347048770887,0.462646938285241,0.3347503075702773,0.6201148857375438,0.20752784337312566,5453]
["O95900","Mitochondrial mRNA pseudouridine synthase TRUB2 [OS=Homo sapiens]",12,4,9,3,331,36.7,8.98,19.47,"RNA metabolism OR transcription;other metabolic processes;other biological processes","mitochondrion;other cell component","other molecular function","TRUB2","ENSG00000167112","","","",238.8,236.1,242.8,292.1,270.8,240.2,0.8936620595193624,-0.16219871899005342,0.134153276277672,0.8723987165668509,0.360222739277555,0.44342887555019384,2722]
["O95905","Protein ecdysoneless homolog [OS=Homo sapiens]",15,6,10,6,644,72.7,4.87,14.3,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","ECD","ENSG00000122882","","","",502.7,490.5,517.3,683.1,740.1,818.3,0.673879098817756,-0.5694383153227475,0.003654508469180652,2.4371710273183416,0.06436337928009973,1.191361162146461,415]
["O95983-1","methyl-CpG-binding domain protein 3 [OS=Homo sapiens]",6,2,3,2,291,32.8,5.34,7.15,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MBD3","ENSG00000071655; ENSPTRG00000010209","","Potential therapeutics for SARS; HDACs deacetylate histones; Regulation of PTEN gene transcription; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation","Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome",353.9,287.1,327.8,424.9,477.5,172.1,0.9016286644951139,-0.14939471262081724,0.732851560233253,0.13498398320339394,0.8182725410548192,0.0871020222914065,6546]
["O95985","DNA topoisomerase 3-beta-1 [OS=Homo sapiens]",14,8,10,8,862,96.6,8.12,22.94,"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TOP3B","ENSG00000100038","Homologous recombination; Fanconi anemia pathway","","",517.3,490.8,499.2,477.9,512.6,783.3,0.8497575825910475,-0.23487676454854836,0.4109405890784058,0.3862209608500814,0.5881270345749106,0.23052885682164845,5107]
["O95989","Diphosphoinositol polyphosphate phosphohydrolase 1 [OS=Homo sapiens]",33,5,11,5,172,19.5,6.34,27.02,"cell-cell signaling;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","NUDT3","ENSG00000272325","","Synthesis of pyrophosphates in the cytosol","",1014.4,1103,1085.5,1091.1,987.9,1159,0.9891599752933912,-0.015724230224177852,0.8464383128679667,0.07240468712060276,0.9009199983620166,0.04531377263083514,6867]
["O95997","Securin [OS=Homo sapiens]",11,2,2,2,202,22,6.6,5.51,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PTTG1","ENSG00000164611","Cell cycle; Oocyte meiosis; Human T-cell leukemia virus 1 infection","APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids","Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition",116.2,116.6,104.7,109.4,116.7,138.3,0.9261800219538967,-0.11063545697649534,0.3992874804583933,0.39871430676803477,0.5810058121979687,0.2358195230436111,5023]
["O95999","B-cell lymphoma/leukemia 10 [OS=Homo sapiens]",3,1,1,1,233,26.2,5.74,2.09,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","BCL10","ENSG00000142867","NF-kappa B signaling pathway; C-type lectin receptor signaling pathway; T cell receptor signaling pathway; B cell receptor signaling pathway; Shigellosis; Tuberculosis","E3 ubiquitin ligases ubiquitinate target proteins; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling","B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Modulators of TCR signaling and T cell activation; T-cell receptor (TCR) signaling pathway",55.6,67.5,69.6,71.9,47.3,372.4,0.39198535394629785,-1.3511283440769404,0.39476952039010643,0.40365638598564385,0.5788105164556244,0.23746358674934542,4985]
["O96000","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [OS=Homo sapiens]",26,4,6,4,172,20.8,8.48,9.51,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity","NDUFB10","ENSG00000140990","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Modulators of TCR signaling and T cell activation; Oxidative phosphorylation",247.7,227.7,222.3,345.3,311.7,298.7,0.7300408077848698,-0.45395098494486447,0.005643885985015696,2.2484217682307097,0.07783238238581079,1.1088396759475256,530]
["O96005-1","Cleft lip and palate transmembrane protein 1 [OS=Homo sapiens]",33,14,54,14,669,76,6.3,171.56,"developmental processes;other biological processes","plasma membrane;other membranes;other cell component","","CLPTM1","ENSG00000104853","","","",3790.5,3706.1,3728.3,3384.4,3465.6,5415.3,0.9151753320342757,-0.1278799291690556,0.6292229196139059,0.20119546646744366,0.7416530107173098,0.12979923593042136,6201]
["O96006","zinc finger BED domain-containing protein 1 [OS=Homo sapiens]",1,1,1,1,694,78.1,6.1,2.51,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBED1","ENSG00000214717","","SUMOylation of chromatin organization proteins","",31,42.2,36.3,52.4,46.8,30.5,0.8442559753276794,-0.2442476097631635,0.4098161827006561,0.3874108963037001,0.5874380230161004,0.2310379463872007,5099]
["O96007","molybdopterin synthase catalytic subunit [OS=Homo sapiens]",20,4,5,4,188,20.9,5.44,12.16,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","MOCS2","ENSG00000164172","Folate biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Sulfur relay system","Molybdenum cofactor biosynthesis","",403,414.5,439.8,500.4,472.2,245.9,1.0318424292162494,0.04522267624107228,0.8812788073377301,0.05488667350314462,0.9225532516229547,0.035008556097331674,6982]
["O96008","Mitochondrial import receptor subunit TOM40 homolog [OS=Homo sapiens]",50,14,97,14,361,37.9,7.25,383.07,"cell organization and biogenesis;transport","other membranes;cytosol;mitochondrion;other cell component","transporter activity","TOMM40","ENSG00000130204","Amyotrophic lateral sclerosis; Pathways of neurodegeneration","Mitochondrial protein import; PINK1-PRKN Mediated Mitophagy","IL-18 signaling pathway",6081.1,6375.3,6315.5,5441.5,5074.6,5515.4,1.1709384648972336,0.2276652613897284,5.001840703349302E-3,2.30087014362471,0.07355825694321942,1.1333685704740692,497]
["O96011-1","Peroxisomal membrane protein 11B [OS=Homo sapiens]",31,8,22,8,259,28.4,9.85,65.56,"cell organization and biogenesis;signal transduction","other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PEX11B","ENSG00000131779; ENSPPAG00000024465; ENSPTRG00000001203","Peroxisome","Class I peroxisomal membrane protein import","",2824.1,2625.5,2513.6,2543.1,2369.1,3112.4,0.9923485282755526,-0.011081188281970184,0.9366973665066047,0.028400700772671292,0.9625082316598866,0.016595547586548944,7113]
["O96013-1","serine/threonine-protein kinase PAK 4 [OS=Homo sapiens]",2,1,1,1,591,64,9.73,4.48,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;ER/Golgi;other cell component","kinase activity;other molecular function","PAK4","ENSG00000130669","ErbB signaling pathway; Ras signaling pathway; Axon guidance; Focal adhesion; T cell receptor signaling pathway; Regulation of actin cytoskeleton; Human immunodeficiency virus 1 infection; MicroRNAs in cancer; Renal cell carcinoma","CDC42 GTPase cycle; RAC3 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; Activation of RAC1; RHOH GTPase cycle","Integrin-mediated cell adhesion; Focal adhesion; Ras signaling; Pancreatic adenocarcinoma pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; 22q11.2 copy number variation syndrome; Malignant pleural mesothelioma; Regulation of actin cytoskeleton; ErbB signaling pathway",124.9,128.2,120.6,151.7,172,269.7,0.6297607010448265,-0.6671243630995223,0.11520641987928827,0.9385233191726681,0.337763226192426,0.4713876357924685,2493]
["O96017-1","Serine/threonine-protein kinase Chk2 [OS=Homo sapiens]",25,10,20,10,543,60.9,5.91,64.49,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","CHEK2","ENSG00000183765","Cell cycle; p53 signaling pathway; Cellular senescence; Human T-cell leukemia virus 1 infection","Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Regulation of TP53 Activity through Methylation; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Stabilization of p53","miRNA regulation of DNA damage response; Cell cycle; ATM signaling in development and disease ; miRNA regulation of p53 pathway in prostate cancer; DNA damage response",1243.6,1271.8,1210.5,1221.8,1123,1203.8,1.0499633658344132,0.070338991842794,0.16815844114732906,0.7742813272688006,0.4002181850686513,0.3977031818278965,3071]
["O96018","amyloid-beta A4 precursor protein-binding family A member 3 [OS=Homo sapiens]",14,5,7,5,575,61.4,4.94,15.3,"cell-cell signaling;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","enzyme regulator activity;other molecular function","APBA3","ENSG00000011132","","Neurexins and neuroligins","",561.4,533.4,567.8,629.5,584.2,574.5,0.9297617716139133,-0.10506698612753265,0.10408489508619086,0.9826122912069442,0.3195113390109068,0.495513724727851,2381]
["O96019-1","Actin-like protein 6A [OS=Homo sapiens]",37,12,55,12,429,47.4,5.6,163.76,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;nucleus","other molecular function","ACTL6A","ENSCANG00000034249; ENSCATG00000017467; ENSCCAG00000029449; ENSCJAG00000013036; ENSCSAG00000013017; ENSG00000136518; ENSGGOG00000015710; ENSMFAG00000030153; ENSMMUG00000009742; ENSPANG00000024431; ENSPPAG00000031814; ENSPTRG00000023973; ENSRBIG00000036584; ENSRROG00000035215","Thermogenesis; Hepatocellular carcinoma","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines; UCH proteinases; HATs acetylate histones; DNA Damage Recognition in GG-NER","Gastric cancer network 1; Tumor suppressor activity of SMARCB1; Thermogenesis",8472.6,8171.1,8119.3,9685.1,10079.6,8348.3,0.8808380464553766,-0.18305130962830765,0.1053143879904908,0.977512291701364,0.3213957669404999,0.492959847567973,2395]
["O96028-1","Histone-lysine N-methyltransferase NSD2 [OS=Homo sapiens]",13,14,20,14,1365,152.2,8.69,51.59,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NSD2","ENSG00000109685","Lysine degradation; Metabolic pathways; Transcriptional misregulation in cancer","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; PKMTs methylate histone lysines; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)","",1118.9,1164.8,1187.8,1394.4,1516.1,1245.2,0.8353586640036577,-0.2595323384017059,0.047891238712386604,1.3197439297354914,0.21687550418143353,0.66378949823757,1614]
["P00156","cytochrome b [OS=Homo sapiens]",2,1,1,1,380,42.7,8.05,2.39,"other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MT-CYB","ENSG00000198727","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly",198,240.3,264.7,164.5,181.3,105.5,1.557722136051407,0.6394379107474104,0.04959219639406093,1.3045866567684354,0.22061434171892352,0.6563662583195241,1643]
["P00167-1","Cytochrome b5 [OS=Homo sapiens]",49,5,12,5,134,15.3,4.96,47.76,"other metabolic processes;transport;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cell component","transporter activity;other molecular function","CYB5A","ENSG00000166347; ENSPTRG00000010111","","Vitamin C (ascorbate) metabolism","Oxidation by cytochrome P450",1614.5,1536.7,1569.2,2164.5,2172.5,1578.4,0.7979849207154207,-0.32556661036283463,0.11456950257539027,0.9409309724724568,0.33657093823292905,0.472923386607265,2488]
["P00338-1","L-lactate dehydrogenase A chain [OS=Homo sapiens]",66,23,487,21,332,36.7,8.27,1452.1,"other metabolic processes;stress response;developmental processes;other biological processes","cytosol;other cell component","other molecular function","HEL-S-133P; LDHA","ENSG00000134333; ENSG00000288299","Glycolysis / Gluconeogenesis; Cysteine and methionine metabolism; Pyruvate metabolism; Propanoate metabolism; Metabolic pathways; HIF-1 signaling pathway; Glucagon signaling pathway; Central carbon metabolism in cancer","Pyruvate metabolism","Cori cycle; HIF1A and PPARG regulation of glycolysis; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling pathway; Amino acid metabolism; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - VitD3 signaling; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Orexin receptor pathway; CCL18 signaling pathway; Glycolysis and gluconeogenesis",57290.2,58323.6,56753.2,51375.8,45637.8,33748.3,1.318174483546048,0.39854134901489496,0.05631898663677192,1.2493451681773344,0.23441655656501478,0.6300117178634452,1756]
["P00367","Glutamate dehydrogenase 1, mitochondrial [OS=Homo sapiens]",47,24,162,24,558,61.4,7.8,471.84,"other metabolic processes;other biological processes","mitochondrion;ER/Golgi;other cell component","other molecular function","GLUD1","ENSG00000148672","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Nitrogen metabolism; Metabolic pathways; Carbon metabolism; Necroptosis; Proximal tubule bicarbonate reclamation","Transcriptional activation of mitochondrial biogenesis; Glutamate and glutamine metabolism","VEGFA-VEGFR2 signaling pathway; Amino acid metabolism; Metabolic reprogramming in colon cancer; 22q11.2 copy number variation syndrome; Amino acid metabolism pathway excerpt: histidine catabolism extension",17804.1,17800.5,17595.3,15392.9,15169.1,18358.2,1.0874832891116553,0.12099323185701931,0.23831443520656445,0.6228496507266239,0.46773367532888815,0.330001361151956,3724]
["P00374","dihydrofolate reductase [OS=Homo sapiens]",41,7,22,7,187,21.4,7.42,58.4,"cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;mitochondrion","nucleic acid binding activity;other molecular function","DHFR","ENSG00000228716","One carbon pool by folate; Folate biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Antifolate resistance","G1/S-Specific Transcription; Metabolism of folate and pterines; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation","Fluoropyrimidine activity; Folate metabolism; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration and one-carbon metabolism; Ethanol effects on histone modifications; Nucleotide metabolism",2090.4,2179.5,2182.8,2935.6,2891.6,1746.5,0.8519877998864492,-0.23109532308570563,0.3927162079180425,0.4059211744512207,0.577537779411061,0.2384196013005798,4970]
["P00387","NADH-cytochrome b5 reductase 3 [OS=Homo sapiens]",45,12,80,12,301,34.2,7.59,261.81,"other metabolic processes;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CYB5R3","ENSG00000100243","Amino sugar and nucleotide sugar metabolism","Neutrophil degranulation; Phase I - Functionalization of compounds; Vitamin C (ascorbate) metabolism","Oxidation by cytochrome P450",7955.6,8145.3,8163,7180,7109.5,8334.2,1.0724991933238153,0.10097656260764702,0.24593109705055557,0.609186552905942,0.47590955476370417,0.3224755758494941,3777]
["P00390","Glutathione reductase, mitochondrial [OS=Homo sapiens]",47,18,83,18,522,56.2,8.5,280.8,"other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion","other molecular function","GSR","ENSG00000104687","Glutathione metabolism; Metabolic pathways; Thyroid hormone synthesis; Diabetic cardiomyopathy","","Glutathione metabolism; Selenium micronutrient network; Nuclear receptors meta-pathway; NRF2 pathway; Amino acid metabolism; One-carbon metabolism and related pathways; Oxidative stress response; Vitamin D-sensitive calcium signaling in depression; Sulfation biotransformation reaction; Metapathway biotransformation Phase I and II",9169.7,9372.1,9326.9,9536.3,8739.1,9030.8,1.0205997172803245,0.029417147189461493,0.4797035098433487,0.3190271039230496,0.632651200549447,0.19883566348528964,5542]
["P00395","Cytochrome c oxidase subunit 1 [OS=Homo sapiens]",2,1,2,1,513,57,6.7,6.58,"other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MT-CO1","ENSG00000198804","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Electron transport chain: OXPHOS system in mitochondria; Effects of nitric oxide; Nonalcoholic fatty liver disease; Neuroinflammation; Mitochondrial complex IV assembly",360.7,324,314.7,362,315,707.4,0.7219011846287201,-0.47012672342955963,0.3609099793741391,0.4426011092754824,0.5597052915861622,0.25204058715114525,4713]
["P00403","Cytochrome c oxidase subunit 2 [OS=Homo sapiens]",31,6,33,6,227,25.5,4.82,81.38,"other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MT-CO2","ENSG00000198712","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Cytoprotection by HMOX1; Respiratory electron transport; TP53 Regulates Metabolic Genes","Electron transport chain: OXPHOS system in mitochondria; Endothelin pathways; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Neuroinflammation; Mitochondrial complex IV assembly; CCL18 signaling pathway",4890.6,4926.3,4901.4,4048.8,4186.1,5395.3,1.0798300831976053,0.11080431478315321,0.44440572146686624,0.3522203584046778,0.6082699285021209,0.2159036535492612,5340]
["P00439","phenylalanine-4-hydroxylase [OS=Homo sapiens]",2,1,1,1,452,51.8,6.6,0,"other metabolic processes","cytosol","other molecular function","PAH","ENSG00000171759","Phenylalanine metabolism; Phenylalanine, tyrosine and tryptophan biosynthesis; Folate biosynthesis; Metabolic pathways; Biosynthesis of amino acids","Phenylketonuria; Phenylalanine metabolism","Biogenic amine synthesis; Sudden infant death syndrome (SIDS) susceptibility pathways",51.5,65.5,66.4,53,42.1,26.4,1.5094650205761317,0.5940373251019112,0.08605378555403381,1.0652300200596507,0.29172871920892074,0.535020814690379,2156]
["P00441","Superoxide dismutase [Cu-Zn] [OS=Homo sapiens]",97,16,152,16,154,15.9,6.13,551.15,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","SOD1","ENSG00000142168","Peroxisome; Longevity regulating pathway; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Platelet degranulation ; Detoxification of Reactive Oxygen Species","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; AGE/RAGE pathway; Dopamine metabolism; Amyotrophic lateral sclerosis (ALS); Copper homeostasis; Physico-chemical features and toxicity-associated pathways; One-carbon metabolism and related pathways; Oxidative stress response; Extracellular vesicles in the crosstalk of cardiac cells",19148.3,18769.8,18169.1,18055.1,17869.9,29445.5,0.8579894600775578,-0.2209681697583879,0.46536458352796956,0.33220667168024526,0.6221601867579897,0.20609778368782944,5467]
["P00450","Ceruloplasmin [OS=Homo sapiens]",1,1,1,1,1065,122.1,5.72,2.11,"transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi","other molecular function","CP","ENSG00000047457","Porphyrin and chlorophyll metabolism; Ferroptosis","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Metal ion SLC transporters; Iron uptake and transport; Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages); Defective CP causes aceruloplasminemia (ACERULOP)","Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway",57.2,55.3,60,39.3,43,64.3,{"$f":"AVERAGE(S898:U898)/AVERAGE(V898:X898)","v":1.1766712141882674},{"$f":"LOG(Y898,2)","v":0.23471125841908186},{"$f":"TTEST(V898:X898,S898:U898,2,2)","v":0.33635442651511654},0.47320285251086713,{"$f":"AA898*7309/AE898","v":0.5443787651459226},0.2640988238798245,4516]
["P00488","Coagulation factor XIII A chain [OS=Homo sapiens]",1,1,2,1,732,83.2,6.09,2.76,"protein metabolism;other metabolic processes;stress response","non-structural extracellular;other cell component","other molecular function","F13A1","ENSG00000124491","Complement and coagulation cascades; Coronavirus disease","Platelet degranulation ; Interleukin-4 and Interleukin-13 signaling; Common Pathway of Fibrin Clot Formation","Complement system",89.1,79.8,81,66.3,70.2,52.8,1.3201267828843106,0.4006764903829987,0.028521040658217846,{"$f":"-LOG10(AA899)","v":1.5448346322606987},0.1671694355821285,{"$f":"-LOG10(AC899)","v":0.7768431238552683},1247]
["P00491","purine nucleoside phosphorylase [OS=Homo sapiens]",66,15,60,15,289,32.1,6.95,220.04,"other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","PNP","ENSG00000198805","Purine metabolism; Pyrimidine metabolism; Nicotinate and nicotinamide metabolism; Metabolic pathways","Neutrophil degranulation; Purine catabolism; Purine salvage","VEGFA-VEGFR2 signaling pathway",6108.9,6424.2,6529,5834.4,5076.4,5116.8,1.1893296563428086,0.25014865423644855,0.021661823136253668,1.6643049944007096,0.14728024679337492,0.8318554967683607,1075]
["P00492","Hypoxanthine-guanine phosphoribosyltransferase [OS=Homo sapiens]",62,10,57,10,218,24.6,6.68,199.36,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","other molecular function","HPRT1","ENSG00000165704","Purine metabolism; Drug metabolism; Metabolic pathways","Purine salvage","Mesodermal commitment pathway; Nucleotide metabolism",6582.6,6495.5,6395.6,6218.4,6605.2,3693.7,1.1789880912739976,0.23754914601342128,0.34185595092292625,0.46615685563378584,0.5474638793373506,0.2616445294959898,4564]
["P00505","Aspartate aminotransferase, mitochondrial [OS=Homo sapiens]",51,22,164,22,430,47.5,9.01,475.51,"other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;other cell component","other molecular function","GOT2","ENSG00000125166","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Cysteine and methionine metabolism; Arginine and proline metabolism; Tyrosine metabolism; Phenylalanine metabolism; Phenylalanine, tyrosine and tryptophan biosynthesis; Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids; Fat digestion and absorption","Gluconeogenesis; Glyoxylate metabolism and glycine degradation; Aspartate and asparagine metabolism; Glutamate and glutamine metabolism; Degradation of cysteine and homocysteine","Alanine and aspartate metabolism; Amino acid metabolism; Metabolic reprogramming in colon cancer; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis and gluconeogenesis",24432.9,25144.2,25292.7,21795,20893.5,16135.4,1.2727785814949366,0.34798146310165273,0.039462049603725076,1.4038203618493776,0.19501563255823298,0.7099305739622972,1479]
["P00519","Tyrosine-protein kinase ABL1 [OS=Homo sapiens]",1,1,1,1,1130,122.8,8.66,0,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;kinase activity;other molecular function","ABL1","ENSG00000097007","ErbB signaling pathway; Ras signaling pathway; Cell cycle; Axon guidance; Neurotrophin signaling pathway; Pathogenic Escherichia coli infection; Pathways in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chronic myeloid leukemia; Viral myocarditis","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Factors involved in megakaryocyte development and platelet production; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RHO GTPases Activate WASPs and WAVEs; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Myogenesis; Cyclin D associated events in G1; RUNX2 regulates osteoblast differentiation; HDR through Single Strand Annealing (SSA); Role of ABL in ROBO-SLIT signaling","miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; TP53 network; Cell cycle; Integrated breast cancer pathway; Microtubule cytoskeleton regulation; Pathogenic Escherichia coli infection; Retinoblastoma gene in cancer; ATM signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Imatinib and chronic myeloid leukemia; VEGFA-VEGFR2 signaling pathway; Ras signaling; Acute viral myocarditis; EGF/EGFR signaling pathway; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)",34.6,22.2,17.8,32.6,41,44.8,0.6300675675675675,-0.6664215453737121,0.07770690562573725,1.109540384778397,0.2766486961609905,0.5580713722650157,2053]
["P00558","phosphoglycerate kinase 1 [OS=Homo sapiens]",76,29,692,24,417,44.6,8.1,2197.3,"protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;other membranes;cytosol","kinase activity;other molecular function","PGK1","ENSG00000102144","Glycolysis / Gluconeogenesis; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; HIF-1 signaling pathway","Glycolysis; Gluconeogenesis; Manipulation of host energy metabolism","Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Glycolysis and gluconeogenesis",105229.6,106191.1,104362.4,96243.4,92534.9,93015.5,1.1206176289187342,0.16429409351652802,8.9562206691987643E-4,3.0478752145308468,0.032088733760379295,1.4936474200727723,204]
["P00568","Adenylate kinase isoenzyme 1 [OS=Homo sapiens]",39,6,16,6,194,21.6,8.63,37.83,"other metabolic processes","cytosol;cytoskeleton;other cell component","kinase activity;other molecular function","AK1","ENSG00000106992","Purine metabolism; Thiamine metabolism; Metabolic pathways; Biosynthesis of cofactors","Interconversion of nucleotide di- and triphosphates","",1196.2,1171.3,1141.7,1145.7,1171.7,983.2,1.0632006301884505,0.08841386485227332,0.31827925599498247,0.4971916658103149,0.5350283077431754,0.27162323934059884,4348]
["P00734","Prothrombin [OS=Homo sapiens]",6,3,3,3,622,70,5.9,10.7,"protein metabolism;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi","signal transduction activity or receptor binding;other molecular function","F2","ENSG00000180210","Phospholipase D signaling pathway; Neuroactive ligand-receptor interaction; Complement and coagulation cascades; Platelet activation; Regulation of actin cytoskeleton; Pathogenic Escherichia coli infection; Coronavirus disease; Pathways in cancer","Cell surface interactions at the vascular wall; Regulation of Complement cascade; G alpha (q) signalling events; Peptide ligand-binding receptors; Thrombin signalling through proteinase activated receptors (PARs); Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Intrinsic Pathway of Fibrin Clot Formation; Common Pathway of Fibrin Clot Formation; Defective F8 cleavage by thrombin; Gamma-carboxylation of protein precursors; Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus; Removal of aminoterminal propeptides from gamma-carboxylated proteins; Platelet Aggregation (Plug Formation); Defective factor XII causes hereditary angioedema","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Blood clotting cascade; IL1 and megakaryocytes in obesity; Regulation of actin cytoskeleton; Complement and coagulation cascades",219.4,214,235.1,230,200.1,159.6,1.1336272681024249,0.18094636615879947,0.28615754710839847,0.5433947955381927,0.5100037824470335,0.29242660294170447,4101]
["P00747","Plasminogen [OS=Homo sapiens]",4,3,9,3,810,90.5,7.24,19.13,"cell organization and biogenesis;protein metabolism;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","PLG","ENSG00000122194","Neuroactive ligand-receptor interaction; Complement and coagulation cascades; Staphylococcus aureus infection; Influenza A","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Signaling by PDGF; Platelet degranulation ; Activation of Matrix Metalloproteinases; Dissolution of Fibrin Clot","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Blood clotting cascade; Complement system; Fibrin complement receptor 3 signaling pathway; Complement and coagulation cascades",1456.1,1415.4,1388.1,1165.8,1215.3,1320,1.1509010834616735,0.2027638434338915,0.019839972386686416,1.7024589366333553,0.1420277749013624,0.8476267168362926,1021]
["P00813","adenosine deaminase [OS=Homo sapiens]",69,19,119,19,363,40.7,5.95,352.3,"cell adhesion;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","ADA","ENSG00000196839","Purine metabolism; Metabolic pathways; Primary immunodeficiency","Purine salvage","",10210.9,10319.3,10417.3,10040.6,9749.2,8942.4,1.0771016490209588,0.10715440737368923,0.09141487438149422,1.0389831331915005,0.3000230430419134,0.5228453883415659,2227]
["P00846","ATP synthase subunit A [OS=Homo sapiens]",4,1,5,1,226,24.8,10.1,16.69,"other metabolic processes;stress response;transport;other biological processes","other membranes;mitochondrion","transporter activity","MT-ATP6","ENSG00000198899","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation",891.5,766.1,824.1,723.5,859.9,969,0.9723005798464188,-0.04052571313679904,0.7822462985520222,0.10665648317983242,0.8533489844950344,0.06887332399668589,6700]
["P00918","Carbonic anhydrase 2 [OS=Homo sapiens]",26,5,6,5,260,29.2,7.4,18.9,"other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","CA2","ENSG00000104267","Nitrogen metabolism; Metabolic pathways; Proximal tubule bicarbonate reclamation; Collecting duct acid secretion; Gastric acid secretion; Pancreatic secretion; Bile secretion","Reversible hydration of carbon dioxide; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide","Proximal tubule transport",274.4,251.3,267.2,295.9,269.3,1146.1,0.4633319698474844,-1.1098818633058272,0.34773745322661537,0.4587485309052862,0.5502517959803706,0.25943853126786,4619]
["P00966","Argininosuccinate synthase [OS=Homo sapiens]",5,3,3,3,412,46.5,8.02,6.49,"other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","ASS1","ENSG00000130707","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Metabolic pathways; Biosynthesis of amino acids; Fluid shear stress and atherosclerosis","Urea cycle","Alanine and aspartate metabolism; Amino acid metabolism",395.2,421.6,432.3,416.4,386.2,712.9,0.8242164302210491,-0.27890487179046575,0.4445877063805392,0.35204255046498767,0.6084050825567049,0.215807166550152,5341]
["P00973-1","2'-5'-oligoadenylate synthase 1 [OS=Homo sapiens]",18,6,13,6,400,46,8.22,35.48,"cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component","nucleic acid binding activity;other molecular function","OAS1","ENSG00000089127","NOD-like receptor signaling pathway; Hepatitis C; Measles; Influenza A; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease","OAS antiviral response; Interferon gamma signaling; Interferon alpha/beta signaling","Immune response to tuberculosis; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; Type II interferon signaling (IFNG)",861.1,861,853.6,941.5,876.9,728.7,1.0112284558910132,0.01610896652641422,0.8871159493576379,0.05201961255250158,0.9265405078386647,0.03313558881541626,6998]
["P01008","Antithrombin-III [OS=Homo sapiens]",2,1,2,1,464,52.6,6.71,2.3,"stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi","enzyme regulator activity;other molecular function","SERPINC1","ENSG00000117601","Complement and coagulation cascades","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Intrinsic Pathway of Fibrin Clot Formation; Common Pathway of Fibrin Clot Formation","Complement and coagulation cascades",236,251.7,257.8,228.8,251,486.2,0.7717391304347826,-0.37381483655233083,0.4238659484906443,0.37277147132188104,0.5949752674319414,0.22550108711360045,5207]
["P01023","alpha-2-macroglobulin [OS=Homo sapiens]",1,2,4,2,1474,163.2,6.46,8.32,"other biological processes","non-structural extracellular;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","A2M","ENSG00000175899","Complement and coagulation cascades","Platelet degranulation ; Intrinsic Pathway of Fibrin Clot Formation; Degradation of the extracellular matrix; HDL assembly","Complement system; Complement and coagulation cascades",897.1,972.5,811,855.8,697,913.6,1.0868472267272138,0.12014916140202542,0.4215562149247892,0.37514450359259527,0.5936713631763553,0.2264538995570802,5190]
["P01024","Complement C3 [OS=Homo sapiens]",1,1,1,1,1663,187,6.4,3.6,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity","C3","ENSG00000125730","Neuroactive ligand-receptor interaction; Phagosome; Complement and coagulation cascades; Neutrophil extracellular trap formation; Alcoholic liver disease; Shigellosis; Pertussis; Legionellosis; Leishmaniasis; Chagas disease; Staphylococcus aureus infection; Tuberculosis; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Coronavirus disease; Viral carcinogenesis; Systemic lupus erythematosus","Purinergic signaling in leishmaniasis infection; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; G alpha (i) signalling events; Neutrophil degranulation; Peptide ligand-binding receptors; Alternative complement activation; Activation of C3 and C5","Allograft Rejection; Complement system; TYROBP causal network in microglia; Cells and molecules involved in local acute inflammatory response ; 16p11.2 distal deletion syndrome; Complement system in neuronal development and plasticity; Acquired partial lipodystrophy / Barraquer-Simons syndrome; Complement activation; Complement and coagulation cascades",77.4,76.9,79.1,75.1,71,60.7,1.1286266924564796,0.1745683753924134,0.11026139981871674,0.9575764982553954,0.32988152733319714,0.4816420033448592,2443]
["P01111","GTPase NRas [OS=Homo sapiens]",61,8,33,4,189,21.2,5.17,92.25,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi","other molecular function","NRAS","ENSG00000213281","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; Chemokine signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Mitophagy; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Apelin signaling pathway; Gap junction; Signaling pathways regulating pluripotency of stem cells; C-type lectin receptor signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Thermogenesis; Long-term potentiation; Neurotrophin signaling pathway; Cholinergic synapse; Serotonergic synapse; Long-term depression; Regulation of actin cytoskeleton; Insulin signaling pathway; GnRH signaling pathway; Estrogen signaling pathway; Melanogenesis; Prolactin signaling pathway; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Relaxin signaling pathway; GnRH secretion; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Alzheimer disease; Pathways of neurodegeneration; Alcoholism; Hepatitis C; Hepatitis B; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Endometrial cancer; Glioma; Prostate cancer; Thyroid cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis","Neutrophil degranulation; Tie2 Signaling; FCERI mediated MAPK activation; Regulation of RAS by GAPs; Signaling by BRAF and RAF1 fusions; Signaling by SCF-KIT; Downstream signal transduction; DAP12 signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; GRB2 events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; GRB2 events in EGFR signaling; SHC1 events in EGFR signaling; NCAM signaling for neurite out-growth; Signaling by FGFR1 in disease; p38MAPK events; SHC-mediated cascade:FGFR1; FRS-mediated FGFR1 signaling; SHC-mediated cascade:FGFR2; FRS-mediated FGFR2 signaling; Signaling by FGFR2 in disease; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ; SHC-mediated cascade:FGFR3; FRS-mediated FGFR3 signaling; FRS-mediated FGFR4 signaling; SHC-mediated cascade:FGFR4; Signaling by FGFR3 point mutants in cancer; FLT3 Signaling; Activated NTRK2 signals through FRS2 and FRS3; RAS processing; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; CD209 (DC-SIGN) signaling; Activation of RAS in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; SOS-mediated signalling; SHC-related events triggered by IGF1R; Signaling by FGFR4 in disease; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants; RAS signaling downstream of NF1 loss-of-function variants; Insulin receptor signalling cascade; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; MET activates RAS signaling; Signaling by FGFR3 fusions in cancer; Activated NTRK2 signals through RAS; Activated NTRK3 signals through RAS; Constitutive Signaling by Overexpressed ERBB2; RAS GTPase cycle mutants; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants","Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; RalA downstream regulated genes; TNF-alpha signaling pathway; Aryl hydrocarbon receptor Netpath; Bladder cancer; Extracellular vesicle-mediated signaling in recipient cells; RAC1/PAK1/p38/MMP2 pathway; G protein signaling pathways; BDNF-TrkB signaling; MAPK signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MAPK cascade; Ras signaling; Non-small cell lung cancer; Breast cancer pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Synaptic signaling pathways associated with autism spectrum disorder; Hippo-Merlin signaling dysregulation; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; EGFR tyrosine kinase inhibitor resistance; Kisspeptin/kisspeptin receptor system in the ovary; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; ErbB signaling pathway; DNA damage response (only ATM dependent); Serotonin receptor 2 and ELK-SRF/GATA4 signaling",1633.6,1790.5,1836.5,1441.5,1523.1,1400.7,1.205094724303026,0.269146551360795,0.013779118090935571,1.8607785778200372,0.12061266362472825,0.9186070914196662,835]
["P01116-2","Isoform 2B of GTPase KRas [OS=Homo sapiens]",61,8,40,4,188,21.4,8.12,99.1,"","","","KRAS","","","","",1437.8,1338.5,1398,1359.6,1405.8,1656.1,0.9440913717064345,-0.08300160063019861,0.4413652787288454,0.3552018348571416,0.6067216141111775,0.2170105332873472,5317]
["P01130","Low-density lipoprotein receptor [OS=Homo sapiens]",20,16,21,16,860,95.3,5.05,57.91,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","LDLR","ENSG00000130164","Endocytosis; Ovarian steroidogenesis; Aldosterone synthesis and secretion; Cortisol synthesis and secretion; Cushing syndrome; Bile secretion; Cholesterol metabolism; Toxoplasmosis; Hepatitis C; Lipid and atherosclerosis","Retinoid metabolism and transport; Cargo recognition for clathrin-mediated endocytosis; LDL clearance; Chylomicron clearance","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Oncostatin M signaling pathway; PCSK9-mediated LDL receptor degradation; Evolocumab mechanism to reduce LDL cholesterol; Lipid particles composition; Wnt signaling pathway and pluripotency; Statin inhibition of cholesterol production; Bile acids synthesis and enterohepatic circulation ; Metabolic pathway of LDL, HDL and TG, including diseases; Orexin receptor pathway; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5; DNA damage response (only ATM dependent)",2228.1,2230.4,2250,3481.6,4009.7,2908,0.6450914965430365,-0.632424295208476,0.018049650960966498,1.7435311919406984,0.1362860525554795,0.8655485873651191,968]
["P01591","Immunoglobulin J chain [OS=Homo sapiens]",38,3,20,3,159,18.1,5.24,60.44,"cell organization and biogenesis;stress response;other biological processes","non-structural extracellular","signal transduction activity or receptor binding;other molecular function","JCHAIN","ENSG00000132465","","Cell surface interactions at the vascular wall; Scavenging of heme from plasma","",985.2,1034.8,1000.5,1289,1348.9,1275,0.7719338597970815,-0.37345085391018834,3.8546016075505316E-4,3.4140205018110406,0.021671756268912948,1.6641058922339045,130]
["P01834","immunoglobulin kappa constant [OS=Homo sapiens]",19,1,1,1,107,11.8,6.52,5.11,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","IGKC","","","Initial triggering of complement; Classical antibody-mediated complement activation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; Scavenging of heme from plasma; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Regulation of Complement cascade; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers","",70.6,187,21.1,16.3,26.6,23.5,4.197289156626506,2.0694578557568843,0.2242389834196272,0.6492888841036706,0.4561543918213346,0.34088813942434704,3593]
["P01854","immunoglobulin heavy constant epsilon [OS=Homo sapiens]",4,1,1,1,428,47,8.06,2.5,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","IGHE","ENSG00000211891; ENSG00000276192","","FCERI mediated NF-kB activation; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; Interleukin-4 and Interleukin-13 signaling","",165.4,160.3,161.5,170.6,157.6,79.9,1.1938250428816468,0.25559142264823204,0.4051203202753328,0.39241597265911826,0.5847204622615338,0.23305170778444398,5064]
["P01857","Immunoglobulin heavy constant gamma 1 [OS=Homo sapiens]",11,2,6,2,330,36.1,8.19,24.71,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","IGHG1","ENSG00000211896; ENSG00000277633","","Initial triggering of complement; Classical antibody-mediated complement activation; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Regulation of Complement cascade; Interleukin-4 and Interleukin-13 signaling","Interactions of natural killer cells in pancreatic cancer",434.9,484,391.4,438.1,478.4,278.6,1.0963936072295206,0.1327658213416706,0.5951663764262698,0.2253616119799967,0.7171234825749433,0.14440605607066842,6066]
["P01889","HLA class I histocompatibility antigen, B-7 alpha chain [OS=Homo sapiens]",43,13,95,3,362,40.4,5.85,312.16,"stress response;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","HLA-B","ENSG00000234745","Endocytosis; Phagosome; Cellular senescence; Cell adhesion molecules; Antigen processing and presentation; Natural killer cell mediated cytotoxicity; Type I diabetes mellitus; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Viral carcinogenesis; Autoimmune thyroid disease; Allograft rejection; Graft-versus-host disease; Viral myocarditis","DAP12 interactions; Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ER-Phagosome pathway; Interferon gamma signaling; Interferon alpha/beta signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Endosomal/Vacuolar pathway","Proteasome degradation; Allograft Rejection; Ebola virus pathway in host; Type II interferon signaling (IFNG)",3654.5,3560.7,3578.3,2784,3336.8,5387.5,0.9378883067003815,-0.0925119727481376,0.7786502352583655,0.10865758084939742,0.8513320223640081,0.0699010305634276,6685]
["P01903","HLA class II histocompatibility antigen, DR alpha chain [OS=Homo sapiens]",26,5,14,5,254,28.6,5,51.51,"other biological processes","plasma membrane;other membranes;other cytoplasmic organelle","","HLA-DRA","","","","",1273.9,1403.6,1360.9,1142.2,1217.1,1160.1,1.1474683184633745,0.1984543214589067,0.017520938396360652,1.7564426373547284,0.1353705483498943,0.8684758118725481,946]
["P01911","HLA class II histocompatibility antigen, DRB1-15 beta chain [OS=Homo sapiens]",23,6,13,2,266,29.9,7.74,31.26,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","HLA-DRB1","ENSG00000196126","Phagosome; Cell adhesion molecules; Antigen processing and presentation; Hematopoietic cell lineage; Th1 and Th2 cell differentiation; Th17 cell differentiation; Intestinal immune network for IgA production; Type I diabetes mellitus; Leishmaniasis; Toxoplasmosis; Staphylococcus aureus infection; Tuberculosis; Influenza A; Human T-cell leukemia virus 1 infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Asthma; Autoimmune thyroid disease; Inflammatory bowel disease; Systemic lupus erythematosus; Rheumatoid arthritis; Allograft rejection; Graft-versus-host disease; Viral myocarditis","Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling","Allograft Rejection; Vitamin D receptor pathway; Ebola virus pathway in host; Cancer immunotherapy by PD-1 blockade; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Genes associated with the development of rheumatoid arthritis; Network map of SARS-CoV-2 signaling pathway; Cytokines and inflammatory response",495.6,438.9,455.6,399.2,444.3,699.3,0.9010241120041482,-0.15036238085370435,0.6202619723707885,0.20742484417080784,0.7351215754918263,0.13364083071313965,6167]
["P02042","Hemoglobin subunit delta [OS=Homo sapiens]",13,2,25,1,147,16,8.05,63.89,"other metabolic processes;transport;other biological processes","cytosol;other cell component","other molecular function","HBD","ENSG00000223609","","Factors involved in megakaryocyte development and platelet production","VEGFA-VEGFR2 signaling pathway",962.2,813.1,962.1,710.8,844.7,685.9,1.2212902650129385,0.2884061275380891,0.07750001913072756,1.1106981902889363,0.2764507759036055,0.5583821868061584,2049]
["P02533","Keratin, type I cytoskeletal 14 [OS=Homo sapiens]",42,19,57,6,472,51.5,5.16,160.3,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KRT14","ENSG00000186847","Estrogen signaling pathway; Staphylococcus aureus infection","Formation of the cornified envelope; Type I hemidesmosome assembly","Corticotropin-releasing hormone signaling pathway",3179.3,4946.9,2798.3,2558.6,3424,8519.1,0.7533254721860195,-0.4086547829002766,0.5783484858588117,0.2378103970821141,0.7055832220233776,0.15145175478850606,5991]
["P02538","Keratin, type II cytoskeletal 6A [OS=Homo sapiens]",33,23,73,4,564,60,8,179.44,"cell organization and biogenesis;stress response;other biological processes","cytosol;cytoskeleton","cytoskeletal activity","KRT6A","ENSG00000205420","","Formation of the cornified envelope","Ectoderm differentiation; Ectoderm differentiation",3173.5,4767,2540.4,2384.4,3413.9,15991.8,0.4809936622594665,-1.0559102102206863,0.4421840994664836,0.3543968783066535,0.6069340061972823,0.21685852853345594,5325]
["P02545","Prelamin-A/C [OS=Homo sapiens]",66,46,249,43,664,74.1,7.02,742.27,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","LMNA","ENSG00000160789","Apoptosis; Hypertrophic cardiomyopathy; Arrhythmogenic right ventricular cardiomyopathy; Dilated cardiomyopathy","Signaling by BRAF and RAF1 fusions; XBP1(S) activates chaperone genes","Arrhythmogenic right ventricular cardiomyopathy; Adipogenesis; Fas ligand pathway and stress induction of heat shock proteins; Lamin A-processing pathway; Nephrotic syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome",27253,26675.5,26305.8,26818.7,26635.8,27545.9,0.9905420220147062,-0.013709914657756825,0.5497400972044659,0.25984258510167213,0.6841563716103255,0.16484462406065623,5873]
["P02647","Apolipoprotein A-I [OS=Homo sapiens]",8,2,13,1,267,30.8,5.76,31.99,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;other molecular function","APOA1","ENSG00000118137","PPAR signaling pathway; Fat digestion and absorption; Vitamin digestion and absorption; Cholesterol metabolism; African trypanosomiasis; Lipid and atherosclerosis","PPARA activates gene expression; Platelet degranulation ; Scavenging of heme from plasma; Amyloid fiber formation; Scavenging by Class B Receptors; Heme signaling; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Retinoid metabolism and transport; HDL clearance; Defective ABCA1 causes TGD; HDL assembly; Scavenging by Class A Receptors; ABC transporters in lipid homeostasis; Chylomicron assembly; Chylomicron remodeling; HDL remodeling","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Complement system; PPAR-alpha pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Statin inhibition of cholesterol production; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5",391.4,384.8,415,335.9,388.3,191,1.3015734265734267,0.38025670180371063,0.1982379313936066,0.7028132427932194,0.43328978485522446,0.3632215496762253,3344]
["P02649","Apolipoprotein E [OS=Homo sapiens]",5,2,4,2,317,36.1,5.73,10.12,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;cytoskeletal activity;other molecular function","APOE","ENSG00000130203","Cholesterol metabolism; Alzheimer disease","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Amyloid fiber formation; Retinoid metabolism and transport; Nuclear signaling by ERBB4; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Chylomicron clearance; Scavenging by Class A Receptors; Chylomicron assembly; Chylomicron remodeling; HDL remodeling; Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors","Vitamin B12 metabolism; Alzheimer's disease and miRNA effects; Apoptosis-related network due to altered Notch3 in ovarian cancer; ApoE and miR-146 in inflammation and atherosclerosis; Statin inhibition of cholesterol production; Familial hyperlipidemia type 3; Alzheimer's disease",442.7,451.6,472.5,381.4,406.5,448.1,1.1058252427184465,0.14512340963753098,0.1108086555566929,0.9554263143937747,0.3308416925914496,0.4803797659833252,2448]
["P02656","Apolipoprotein C-III [OS=Homo sapiens]",16,1,2,1,99,10.8,5.41,10.27,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","non-structural extracellular;other cytoplasmic organelle","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","APOC3","ENSG00000110245","PPAR signaling pathway; Cholesterol metabolism","Retinoid metabolism and transport; Chylomicron assembly; Chylomicron remodeling; HDL remodeling","PPAR-alpha pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Statin inhibition of cholesterol production",80.8,84.1,81.6,70.3,76.5,148.2,0.835593220338983,-0.2591273078712922,0.5533431053810558,0.2570054969646764,0.68665276014094,0.16326282986780508,5890]
["P02671-1","Fibrinogen alpha chain [OS=Homo sapiens]",1,1,1,1,866,94.9,6.01,2.72,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGA","ENSG00000171560","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Coronavirus disease","ER-Phagosome pathway; Signaling by BRAF and RAF1 fusions; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Amyloid fiber formation; Integrin cell surface interactions; Platelet degranulation ; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Common Pathway of Fibrin Clot Formation; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway",150.5,159.6,101.1,152.1,110.1,101.3,1.1312242090784046,0.17788490038692165,0.5438656080226767,0.26450840343564486,0.6796227951851161,0.1677320629149941,5849]
["P02675","Fibrinogen beta chain [OS=Homo sapiens]",7,4,12,4,491,55.9,8.27,24.85,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGB","ENSG00000171564","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Coronavirus disease","ER-Phagosome pathway; Platelet degranulation ; Common Pathway of Fibrin Clot Formation; Integrin cell surface interactions; Signaling by BRAF and RAF1 fusions; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway; Complement and coagulation cascades",2203.5,2088.2,1227.4,1798.2,1322.1,1446.4,1.2085532222392537,0.27328100787380366,0.4024939984573198,0.39524059096394115,0.5832332741325437,0.23415770698101224,5044]
["P02679","Fibrinogen gamma chain [OS=Homo sapiens]",2,1,2,1,453,51.5,5.62,5.09,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGG","ENSG00000171557","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Staphylococcus aureus infection; Coronavirus disease","ER-Phagosome pathway; Platelet degranulation ; Integrin cell surface interactions; Signaling by BRAF and RAF1 fusions; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Common Pathway of Fibrin Clot Formation; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway",215.6,230,76.6,196.3,118.6,109,1.2318943146968628,0.3008784912577468,0.5910279060565888,0.2283920129253995,0.7139023244699402,0.1463612039738544,6051]
["P02686-1","myelin basic protein [OS=Homo sapiens]",3,1,1,1,304,33.1,9.79,2,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","MBP","ENSG00000197971; ENSGGOG00000009590","","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Neural crest differentiation; Glial cell differentiation; Spinal cord injury; Interleukin-1 (IL-1) structural pathway; MECP2 and associated Rett syndrome; MAPK cascade; Complement system in neuronal development and plasticity",38.1,34.8,32.4,36.9,28.5,66.2,0.8001519756838905,-0.32165405270952474,0.48995996555389193,0.3098394045619831,0.6408585161477086,0.1932378401201545,5588]
["P02749","Beta-2-glycoprotein 1 [OS=Homo sapiens]",4,2,5,2,345,38.3,7.97,7.37,"protein metabolism;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;other cell component","enzyme regulator activity;other molecular function","APOH","ENSG00000091583","Cholesterol metabolism","Platelet degranulation","",555.8,553.5,601.2,494.6,717.9,548.3,0.971433439345752,-0.041812946236295036,0.820119440866354,0.08612289306546157,0.8817671364066169,0.054646091428529504,6798]
["P02751","fibronectin [OS=Homo sapiens]",12,20,36,20,2386,262.5,5.71,113.49,"","","","","","","","",3028.6,2972.7,1811.1,2711.6,2191.2,2600,1.0412645945513677,0.058336716805058406,0.8209933858762,0.08566034164918242,0.8823174029362073,0.05437515461138926,6801]
["P02753","Retinol-binding protein 4 [OS=Homo sapiens]",4,1,1,1,201,23,6.07,1.83,"other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;other cell component","transporter activity;other molecular function","RBP4","ENSG00000138207","","Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision); Retinoid cycle disease events; Retinoid metabolism disease events","Sterol regulatory element-binding proteins (SREBP) signaling; Vitamin A and carotenoid metabolism",154.2,151.1,173.1,127,195.8,188,0.9365700861393891,-0.09454113550461896,0.6605696390262132,0.18008139114474572,0.7647875006562003,0.11645921858812662,6313]
["P02760","Protein AMBP [OS=Homo sapiens]",2,1,2,1,352,39,6.25,1.84,"cell adhesion;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","enzyme regulator activity;other molecular function","AMBP","ENSG00000106927","","Scavenging of heme from plasma","",408.1,402.8,438,404.6,452.5,286.5,1.092077649527807,0.1270754392302765,0.5255200153900494,0.27941073842182224,0.6666132926910572,0.17612603048224343,5762]
["P02765","Alpha-2-HS-glycoprotein [OS=Homo sapiens]",5,3,23,3,367,39.3,5.72,66.88,"","","","","","","","",3652.5,3898.3,4737.1,3233.2,5121.5,1528.1,1.2433622050431052,0.3142466305010995,0.5022668086585135,0.2990655204124831,0.6491720786003669,0.18764016778998424,5655]
["P02766","Transthyretin [OS=Homo sapiens]",4,1,2,1,147,15.9,5.76,2.01,"other metabolic processes;transport;signal transduction","non-structural extracellular;other cytoplasmic organelle","signal transduction activity or receptor binding;other molecular function","TTR","ENSG00000118271","Thyroid hormone synthesis","Neutrophil degranulation; Amyloid fiber formation; Retinoid metabolism and transport; Non-integrin membrane-ECM interactions; The canonical retinoid cycle in rods (twilight vision); Retinoid cycle disease events","",114.6,119.5,140.8,147.9,165.1,106.3,0.8941092296684949,-0.16147700455829964,0.48419425185731635,0.31498037061809153,0.6358202994655274,0.19666561073214264,5566]
["P02768-1","Serum albumin [OS=Homo sapiens]",12,9,57,9,609,69.3,6.28,144.76,"stress response;other biological processes","non-structural extracellular;ER/Golgi;other cell component","nucleic acid binding activity;other molecular function","ALB","ENSG00000163631","Thyroid hormone synthesis","Cytoprotection by HMOX1; Scavenging of heme from plasma; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Recycling of bile acids and salts; Heme degradation; HDL remodeling; Heme biosynthesis","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Complement system; VEGFA-VEGFR2 signaling pathway",8625.7,9216.3,9668.6,9218.8,11913.2,8098.5,0.9411607738492327,-0.08748690240897039,0.6502291755536076,0.1869335477625817,0.7567715038409741,0.1210352296158049,6280]
["P02771","Alpha-fetoprotein [OS=Homo sapiens]",3,2,5,2,609,68.6,5.68,14.64,"other metabolic processes;developmental processes;signal transduction","non-structural extracellular;ER/Golgi;other cell component","other molecular function","AFP","ENSG00000081051","Hippo signaling pathway","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",979.5,948.2,1015.8,1049.3,1271.3,2405.2,0.6228575056075163,-0.6830259468338229,0.230426854159313,0.6374669092176037,0.4611691886775517,0.3361397161958921,3652]
["P02774","vitamin D-binding protein [OS=Homo sapiens]",8,2,7,2,474,52.9,5.54,29.89,"transport","non-structural extracellular","transporter activity;cytoskeletal activity;other molecular function","HEL-S-51","","","","",393.7,358.1,372.8,380,450.5,1837.1,0.42157744789323737,-1.246130402207342,0.3393536804013992,0.46934743638160137,0.5463295264435741,0.26254532735473235,4540]
["P02786","Transferrin receptor protein 1 [OS=Homo sapiens]",34,25,82,25,760,84.8,6.61,240.32,"protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","TFRC","ENSG00000072274","HIF-1 signaling pathway; Endocytosis; Phagosome; Ferroptosis; Hematopoietic cell lineage","RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; RHOC GTPase cycle; RND2 GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RND1 GTPase cycle; Transferrin endocytosis and recycling; RHOH GTPase cycle","Iron metabolism in placenta; Ferroptosis; 3q29 copy number variation syndrome",9497.1,9995.5,10180.4,9305.5,8895.7,9027,1.0897892626027426,0.12404918161517806,0.026377547919747904,1.5787655793135094,0.1601274898217919,0.7955341043513422,1204]
["P02787","Serotransferrin [OS=Homo sapiens]",2,1,2,1,698,77,7.12,2.06,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","TF","ENSG00000091513","HIF-1 signaling pathway; Ferroptosis; Mineral absorption","Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cargo recognition for clathrin-mediated endocytosis; Transferrin endocytosis and recycling","Iron metabolism in placenta; Pluripotent stem cell differentiation pathway; Ferroptosis; IL-18 signaling pathway; 3q29 copy number variation syndrome; Sudden infant death syndrome (SIDS) susceptibility pathways",133.7,112.8,119.8,147,169.1,386.6,0.5212750818272378,-0.9398831975152812,0.21754340132434877,0.6624540854895634,0.45274052399762676,0.3441506308396554,3512]
["P02788","Lactotransferrin [OS=Homo sapiens]",1,1,1,1,710,78.1,8.12,2.05,"protein metabolism;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","LTF","ENSG00000012223","","Neutrophil degranulation; Amyloid fiber formation; Mtb iron assimilation by chelation; Metal sequestration by antimicrobial proteins","Male infertility",212.2,177.4,203.2,164,183.7,136.2,1.2250464972101676,0.2928365084290352,0.1035740936680684,0.9847488583355227,0.3190151920016485,0.4961886346688888,2373]
["P02792","Ferritin light chain [OS=Homo sapiens]",62,11,90,11,175,20,5.78,266.59,"transport;other biological processes","non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component","other molecular function","FTL","ENSG00000087086","Ferroptosis; Necroptosis; Mineral absorption","Neutrophil degranulation; Scavenging by Class A Receptors; Golgi Associated Vesicle Biogenesis; Iron uptake and transport","Nuclear receptors meta-pathway; NRF2 pathway; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway",15500.3,13193.3,15089.7,10647.9,12880.8,14601.4,1.148260822814522,0.19945038159696266,0.23441385444944837,0.6300167239972301,0.4635635449596911,0.3338907246613262,3696]
["P02794","Ferritin heavy chain [OS=Homo sapiens]",43,5,13,5,183,21.2,5.55,47.17,"transport;other biological processes","non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component","other molecular function","FTH1","ENSG00000167996","Ferroptosis; Necroptosis; Mineral absorption","Neutrophil degranulation; Scavenging by Class A Receptors; Golgi Associated Vesicle Biogenesis; Iron uptake and transport","Iron metabolism in placenta; Nuclear receptors meta-pathway; NRF2 pathway; Ferroptosis",915.4,727,757.5,780.4,734,2290,0.630822205866891,-0.6646946488835851,0.4142678048217483,0.38271881695891946,0.5904608785963648,0.22880887158570748,5128]
["P03891","NADH-ubiquinone oxidoreductase chain 2 [OS=Homo sapiens]",5,2,8,2,347,38.9,9.83,14.21,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;other cell component","signal transduction activity or receptor binding;transporter activity;other molecular function","MT-ND2","ENSG00000198763","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",753.9,780,767.8,654.9,639.3,481.9,1.2959292832610776,0.3739869948644311,0.034784314125046886,1.458616555613622,0.1836983756791674,0.735894683850388,1384]
["P03897","NADH-ubiquinone oxidoreductase chain 3 [OS=Homo sapiens]",13,1,4,1,115,13.2,4.44,10.89,"other metabolic processes;stress response;transport;other biological processes","other membranes;mitochondrion","transporter activity","MT-ND3","ENSG00000198840","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",110.8,116.6,128.2,124,134.2,832.5,0.3260291555881544,-1.6169271097511457,0.3551216590643992,0.4496228390323896,0.555323963650341,0.2554535852046247,4674]
["P03905","NADH-ubiquinone oxidoreductase chain 4 [OS=Homo sapiens]",7,3,13,3,459,51.5,9.35,35.17,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MT-ND4","ENSG00000198886","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",1201.5,1397.1,1312.1,1037.2,961,785.8,1.404705459770115,0.49026765622843144,0.015917205832733275,1.798133167624084,0.12826775902033904,0.8918824928002062,907]
["P03923","NADH-ubiquinone oxidoreductase chain 6 [OS=Homo sapiens]",8,1,2,1,174,18.6,4.22,9.21,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","other membranes;mitochondrion","transporter activity","MT-ND6","ENSG00000198695","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",235,240.8,234.7,154,154.7,186.6,1.4344841510195843,0.5205320284957287,0.002791818006562706,2.5541128959778514,0.05575245303269622,1.2537360194882892,366]
["P03928","ATP synthase protein 8 [OS=Homo sapiens]",13,1,2,1,68,8,9.91,5.52,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","MT-ATP8","ENSG00000228253","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome",925.7,635.2,958.1,605.9,1450.1,69.7,1.1850214047137415,0.24491311836021976,0.7677049681528798,0.11480564887550272,0.8430221773181188,0.07416100027419728,6656]
["P04004","Vitronectin [OS=Homo sapiens]",9,2,18,2,478,54.3,5.8,74.16,"cell adhesion;transport;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;extracellular structural activity;other molecular function","VTN","ENSG00000109072","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Complement and coagulation cascades; Human papillomavirus infection; Proteoglycans in cancer","Regulation of Complement cascade; Integrin cell surface interactions; ECM proteoglycans; Syndecan interactions; Molecules associated with elastic fibres","Primary focal segmental glomerulosclerosis (FSGS); Complement system; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; Inflammatory response pathway; Complement system in neuronal development and plasticity; Senescence and autophagy in cancer",1371.7,1342.4,1309.5,1039.9,1138.2,1014.6,1.260249945187459,0.33370989159958186,2.6813829644916163E-3,2.5716411541306035,0.05520627630273021,1.2580115453017247,355]
["P04040","catalase [OS=Homo sapiens]",49,20,80,20,527,59.7,7.39,257.61,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CAT","ENSG00000121691","Tryptophan metabolism; Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism; FoxO signaling pathway; Peroxisome; Longevity regulating pathway; Longevity regulating pathway; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Chemical carcinogenesis","Neutrophil degranulation; Peroxisomal protein import; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Detoxification of Reactive Oxygen Species","Selenium micronutrient network; Folate metabolism; Amyotrophic lateral sclerosis (ALS); Oxidative stress response; Tryptophan metabolism; Male infertility; DNA damage response (only ATM dependent)",7472.7,7693.5,7621.6,6944.4,6996.2,5750.6,1.1572580645161292,0.21071061628881285,0.06638859710286941,1.177906508592421,0.2547161449999331,0.5939435267200861,1905]
["P04049","RAF proto-oncogene serine/threonine-protein kinase [OS=Homo sapiens]",18,10,19,7,648,73,9.2,53.28,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","RAF1","ENSG00000132155","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Cellular senescence; Vascular smooth muscle contraction; Axon guidance; VEGF signaling pathway; Apelin signaling pathway; Focal adhesion; Gap junction; Signaling pathways regulating pluripotency of stem cells; Neutrophil extracellular trap formation; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Long-term potentiation; Neurotrophin signaling pathway; Serotonergic synapse; Long-term depression; Regulation of actin cytoskeleton; Insulin signaling pathway; GnRH signaling pathway; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Melanogenesis; Prolactin signaling pathway; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Relaxin signaling pathway; Parathyroid hormone synthesis, secretion and action; GnRH secretion; Growth hormone synthesis, secretion and action; Alzheimer disease; Pathways of neurodegeneration; Alcoholism; Salmonella infection; Tuberculosis; Hepatitis C; Hepatitis B; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer","Signaling by BRAF and RAF1 fusions; Stimuli-sensing channels; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; CD209 (DC-SIGN) signaling; Rap1 signalling; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GP1b-IX-V activation signalling; Negative feedback regulation of MAPK pathway","IL-5 signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Endothelin pathways; Pilocytic astrocytoma; Glioblastoma signaling pathways; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Retinoblastoma gene in cancer; Aryl hydrocarbon receptor Netpath; Common pathways underlying drug addiction; Cardiac hypertrophic response; Bladder cancer; IL-3 signaling pathway; Extracellular vesicle-mediated signaling in recipient cells; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; Pathways affected in adenoid cystic carcinoma; TGF-beta signaling pathway; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; ERK pathway in Huntington's disease; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway; Fragile X syndrome; 22q11.2 copy number variation syndrome; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; Netrin-UNC5B signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Regucalcin in proximal tubule epithelial kidney cells; Kisspeptin/kisspeptin receptor system in the ovary; CAMKK2 pathway; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Angiotensin II receptor type 1 pathway; Malignant pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; EPO receptor signaling; Senescence and autophagy in cancer; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling",1757.9,1660.2,1630.7,1874.2,1826.1,2988.4,0.7548253023756484,-0.40578531079366753,0.225293560627562,0.6472512211651285,0.45601513005451416,0.3410207477079822,3611]
["P04053","DNA nucleotidylexotransferase [OS=Homo sapiens]",3,1,1,1,509,58.5,8.43,2.25,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DNTT","ENSG00000107447","Non-homologous end-joining; Hematopoietic cell lineage","","",18.7,10.5,16.7,7.4,8.3,10.3,1.7653846153846153,0.8199825303853534,0.06407698599289506,1.1932979244743607,0.24978063499843733,0.6024412346541254,1875]
["P04062","glucosylceramidase [OS=Homo sapiens]",21,10,25,10,536,59.7,7.61,73.39,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","signal transduction activity or receptor binding;other molecular function","GBA","ENSG00000177628","Other glycan degradation; Sphingolipid metabolism; Metabolic pathways; Lysosome","Glycosphingolipid metabolism; Association of TriC/CCT with target proteins during biosynthesis","Sphingolipid pathway",3169.4,3349.4,3305.4,2972.1,3108.7,4172.5,0.9581500590053935,-0.06167647605588304,0.7279406639285078,0.13790401955874326,0.8147807523205916,0.08895923894984424,6530]
["P04066","tissue alpha-L-fucosidase [OS=Homo sapiens]",21,9,25,9,466,53.7,6.84,71.08,"other metabolic processes","non-structural extracellular;other cytoplasmic organelle;other cell component","other molecular function","FUCA1","ENSG00000179163","Other glycan degradation; Lysosome","Neutrophil degranulation; Reactions specific to the complex N-glycan synthesis pathway","p53 transcriptional gene network",3213.6,3264.4,3187.3,2821,2693.4,2298.4,1.2371108949416343,0.3069748296687507,0.017758864601384875,1.7505848039355631,0.13605821946700425,0.8662752167556854,954]
["P04075","fructose-bisphosphate aldolase A [OS=Homo sapiens]",77,29,534,21,364,39.4,8.09,1806.83,"cell organization and biogenesis;other metabolic processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ALDOA","ENSG00000149925","Glycolysis / Gluconeogenesis; Pentose phosphate pathway; Fructose and mannose metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; HIF-1 signaling pathway","Neutrophil degranulation; Glycolysis; Platelet degranulation ; Gluconeogenesis","VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; 16p11.2 proximal deletion syndrome; Glycolysis and gluconeogenesis; Sudden infant death syndrome (SIDS) susceptibility pathways",63343.9,63675,62475.9,59033.5,57098.5,60892.3,{"$f":"AVERAGE(S962:U962)/AVERAGE(V962:X962)","v":1.0704451309791931},{"$f":"LOG(Y962,2)","v":0.09821084776175971},{"$f":"TTEST(V962:X962,S962:U962,2,2)","v":0.022597506558180998},1.6459394788952744,{"$f":"AA962*7309/AE962","v":0.1493356016579972},0.825836643979981,1106]
["P04080","Cystatin-B [OS=Homo sapiens]",52,4,24,4,98,11.1,7.56,83.31,"other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","CSTB","ENSG00000160213","","Neutrophil degranulation","",3229.3,3293.7,3265.1,3610.7,3643.5,3212.9,0.9351300742325955,-0.09676104069097143,0.1803677689944345,{"$f":"-LOG10(AA963)","v":0.7438410665638101},0.4136517174710768,{"$f":"-LOG10(AC963)","v":0.3833651681535698},3187]
["P04114","apolipoprotein B-100 [OS=Homo sapiens]",1,2,2,2,4563,515.3,7.05,5.51,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;other molecular function","APOB","ENSG00000084674","Fat digestion and absorption; Vitamin digestion and absorption; Cholesterol metabolism; Lipid and atherosclerosis","Heme signaling; Cell surface interactions at the vascular wall; Scavenging by Class B Receptors; Regulation of TLR by endogenous ligand; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Retinoid metabolism and transport; Cargo recognition for clathrin-mediated endocytosis; LDL clearance; Chylomicron clearance; Scavenging by Class A Receptors; Chylomicron assembly; Chylomicron remodeling; VLDL assembly; VLDL clearance; Scavenging by Class F Receptors; Scavenging by Class H Receptors; Platelet sensitization by LDL; LDL remodeling","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Statin inhibition of cholesterol production; Male infertility; Familial hyperlipidemia type 2",200.2,230.7,263.2,201.1,184.1,460.9,0.8203522042311784,-0.2856846556382865,0.6088633690160947,0.21548015357353115,0.7270351844696351,0.1384445711887456,6121]
["P04150","Glucocorticoid receptor [OS=Homo sapiens]",27,15,26,15,777,85.6,6.38,70.1,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","NR3C1","ENSG00000113580","Neuroactive ligand-receptor interaction","Potential therapeutics for SARS; Regulation of RUNX2 expression and activity; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Circadian Clock; SUMOylation of intracellular receptors; PTK6 Expression","Nuclear receptors; Adipogenesis; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Endoderm differentiation; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Transcription factor regulation in adipogenesis; White fat cell differentiation; Vitamin D in inflammatory diseases; 16p11.2 proximal deletion syndrome; Sudden infant death syndrome (SIDS) susceptibility pathways; Serotonin receptor 4/6/7 and NR3C signaling",1754.5,1886.8,1829.5,1932.4,1955.2,1829.2,0.9569689336691856,-0.0634560039993489,0.20685223435568026,0.6843397836246367,0.44297772660582097,0.3536181100193026,3413]
["P04156-1","Major prion protein [OS=Homo sapiens]",20,5,16,5,253,27.6,9,32.24,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function","PRNP","ENSG00000171867","Ferroptosis; Prion disease; Pathways of neurodegeneration","NCAM1 interactions; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","Complement system; Copper homeostasis; Prion disease pathway; Ferroptosis",1414,1362.5,1399.7,1452.4,1590.8,1661.7,0.8876277923016429,-0.17197325476564973,0.049712482542334714,1.3035345485182896,0.22074637600359928,0.6561064175105679,1646]
["P04179","Superoxide dismutase [Mn], mitochondrial [OS=Homo sapiens]",39,7,31,7,222,24.7,8.25,102.06,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","mitochondrion","other molecular function","SOD2","ENSPPAG00000038347","FoxO signaling pathway; Peroxisome; Longevity regulating pathway; Longevity regulating pathway; Huntington disease; Chemical carcinogenesis; Lipid and atherosclerosis","","",3864.1,4079,4173.8,3830.3,3969.7,4373,0.9953914400722913,-0.006664114360630827,0.9250518771316973,0.03383391123904442,0.953759933693832,0.020560925707102932,7089]
["P04181-1","Ornithine aminotransferase, mitochondrial [OS=Homo sapiens]",51,15,92,15,439,48.5,7.03,291.77,"other metabolic processes;other biological processes","mitochondrion;nucleus;other cell component","other molecular function","OAT","ENSG00000065154; ENSPPAG00000034558; ENSPTRG00000003028","Arginine and proline metabolism; Metabolic pathways","Glutamate and glutamine metabolism","Amino acid metabolism; 22q11.2 copy number variation syndrome",8859.5,9524,9938.3,8646.5,7964.1,6560.2,1.22230566057279,0.28960510336524137,0.06756256209702019,1.1702938895406412,0.25679395026891344,0.5904152118951481,1923]
["P04183","Thymidine kinase, cytosolic [OS=Homo sapiens]",43,9,38,9,234,25.5,8.51,104.68,"cell organization and biogenesis;DNA metabolism;other metabolic processes","cytosol","kinase activity;other molecular function","TK1","ENSG00000167900","Pyrimidine metabolism; Drug metabolism; Metabolic pathways","Pyrimidine salvage; G1/S-Specific Transcription","Fluoropyrimidine activity; Pyrimidine metabolism",2704.1,3116.2,3223.2,2661.7,2327.1,1782.2,1.3356225077536557,0.4175123108459314,0.06571815821120579,1.182314616416504,0.2530737715309289,0.5967528626238048,1898]
["P04233-2","Isoform 2 of HLA class II histocompatibility antigen gamma chain [OS=Homo sapiens]",48,10,116,10,232,26.4,9.14,330.43,"","","","CD74","","","","",14813.2,14560,15189.4,12989.7,15204.5,13950.3,1.057376407360391,0.08048904215503482,0.2932954812691266,0.5326946280354758,0.5159318104924299,0.28740769427163276,4155]
["P04259","keratin, type II cytoskeletal 6B [OS=Homo sapiens]",31,21,79,2,564,60,8,188.7,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","cytoskeletal activity","KRT6B","ENSG00000185479","","Formation of the cornified envelope","",265.1,360.6,262.9,194.8,259.3,578.2,0.8607962801511186,-0.21625625144813382,0.7164108568820773,0.14483784123695195,0.8061966055351967,0.09355903476202572,6495]
["P04264","Keratin, type II cytoskeletal 1 [OS=Homo sapiens]",52,37,272,31,644,66,8.12,762.82,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","bone, tooth or skin structural activity;other molecular function","KRT1","ENSG00000167768","","Neutrophil degranulation; Formation of the cornified envelope","Corticotropin-releasing hormone signaling pathway",33987.5,67111.4,34877.4,27217.1,41089.7,33969.5,1.3294996005917303,0.4108833437812019,0.38801226727774857,0.4111545436665783,0.5736208862324159,0.24137504386336472,4944]
["P04406-1","glyceraldehyde-3-phosphate dehydrogenase [OS=Homo sapiens]",79,22,1504,22,335,36,8.46,5838.71,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","GAPDH; HEL-S-162eP; LOC117800120","ENSAMEG00000025937; ENSG00000111640; ENSGGOG00000009553; ENSPPAG00000039909; ENSPTRG00000004577","Glycolysis / Gluconeogenesis; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; HIF-1 signaling pathway; Alzheimer disease; Pathogenic Escherichia coli infection; Salmonella infection; Diabetic cardiomyopathy","Glycolysis; Gluconeogenesis","Cori cycle; Alzheimer's disease and miRNA effects; HIF1A and PPARG regulation of glycolysis; VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; 7q11.23 copy number variation syndrome; Glycolysis in senescence; Alzheimer's disease; Glycolysis and gluconeogenesis; Sudden infant death syndrome (SIDS) susceptibility pathways",140592.3,141186.4,139262.4,125776.7,120659.5,111905.4,1.1749713122897258,0.23262553285615073,0.006932217111066951,2.1591278440161443,0.08661123908510827,1.062425748214352,585]
["P04424","argininosuccinate lyase [OS=Homo sapiens]",19,8,21,8,464,51.6,6.48,62.06,"other metabolic processes","cytosol;other cell component","other molecular function","ASL","ENSG00000126522","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Metabolic pathways; Biosynthesis of amino acids","Urea cycle","Alanine and aspartate metabolism",1920.6,1981.4,2047.9,1753.1,1764.7,2077.2,1.0634316353887399,0.08872729003967629,0.3517149420014332,0.45380918104067114,0.5524789407024447,0.25768427168996555,4653]
["P04632","Calpain small subunit 1 [OS=Homo sapiens]",77,12,90,12,268,28.3,5.2,324.41,"protein metabolism;other biological processes","plasma membrane;other membranes;cytosol","other molecular function","CAPNS1","ENSG00000126247","Shigellosis","Formation of the cornified envelope; Degradation of the extracellular matrix; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models","Integrin-mediated cell adhesion",8150.9,8294.3,8498.9,8200,8346.5,5359.8,1.1386724366962928,0.18735278486842644,0.3586727970219439,0.44530156046164393,0.5584873185840196,0.2529866838402447,4694]
["P04637","Cellular tumor antigen p53 [OS=Homo sapiens]",6,3,3,3,393,43.6,6.79,7.18,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function","TP53","ENSG00000141510","Endocrine resistance; Platinum drug resistance; MAPK signaling pathway; Sphingolipid signaling pathway; Cell cycle; p53 signaling pathway; Mitophagy; PI3K-Akt signaling pathway; Apoptosis; Longevity regulating pathway; Ferroptosis; Cellular senescence; Wnt signaling pathway; Neurotrophin signaling pathway; Thyroid hormone signaling pathway; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Shigellosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Pathways in cancer; Transcriptional misregulation in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Colorectal cancer; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Thyroid cancer; Basal cell carcinoma; Melanoma; Bladder cancer; Chronic myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","TP53 Regulates Transcription of DNA Repair Genes; Autodegradation of the E3 ubiquitin ligase COP1; Ub-specific processing proteases; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of PTEN gene transcription; Factors involved in megakaryocyte development and platelet production; Interleukin-4 and Interleukin-13 signaling; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; TP53 Regulates Transcription of Death Receptors and Ligands; Oxidative Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Association of TriC/CCT with target proteins during biosynthesis; Pre-NOTCH Transcription and Translation; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; TP53 Regulates Transcription of Caspase Activators and Caspases; Regulation of TP53 Activity through Methylation; G2/M DNA damage checkpoint; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Activation of PUMA and translocation to mitochondria; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; Regulation of TP53 Activity through Association with Co-factors; Ovarian tumor domain proteases; Pyroptosis; SUMOylation of transcription factors; Regulation of TP53 Expression; RUNX3 regulates CDKN1A transcription; Activation of NOXA and translocation to mitochondria; Formation of Senescence-Associated Heterochromatin Foci (SAHF); PI5P Regulates TP53 Acetylation; Transcriptional  activation of  cell cycle inhibitor p21 ; Loss of function of TP53 in cancer due to loss of tetramerization ability","AMP-activated protein kinase (AMPK) signaling; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Fluoropyrimidine activity; TP53 network; Folate metabolism; Apoptosis modulation and signaling; Cell cycle; Metastatic brain tumor; Glioblastoma signaling pathways; Gastric cancer network 2; Oncostatin M signaling pathway; Spinal cord injury; Retinoblastoma gene in cancer; Amyotrophic lateral sclerosis (ALS); ATM signaling pathway; Apoptosis; Mammary gland development pathway - Involution (Stage 4 of 4); Bladder cancer; Copper homeostasis; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced HIF-1 survival signaling; Hepatitis C and hepatocellular carcinoma; Pathways affected in adenoid cystic carcinoma; TGF-beta signaling pathway; lncRNA-mediated mechanisms of therapeutic resistance; MAPK signaling pathway; miRNA regulation of p53 pathway in prostate cancer; Wnt signaling pathway and pluripotency; Endometrial cancer; PI3K-Akt signaling pathway; Caloric restriction and aging; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer; Ferroptosis; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; MicroRNA network associated with chronic lymphocytic leukemia; G1 to S cell cycle control; 22q11.2 copy number variation syndrome; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Unfolded protein response; 16p11.2 proximal deletion syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis in senescence; TCA cycle in senescence; Malignant pleural mesothelioma; Senescence and autophagy in cancer; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)",330.7,365.4,386.5,230.8,246.5,335.4,1.3321028669865875,0.41370549379147104,0.06884488454563281,1.1621283240510591,0.2596425496099227,0.5856241348818326,1938]
["P04792","Heat shock protein beta-1 [OS=Homo sapiens]",29,5,7,5,205,22.8,6.4,25.69,"stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","HSPB1","ENSG00000106211","MAPK signaling pathway; VEGF signaling pathway; Amoebiasis","AUF1 (hnRNP D0) binds and destabilizes mRNA; MAPK6/MAPK4 signaling; Extra-nuclear estrogen signaling; VEGFA-VEGFR2 Pathway","Apoptosis-related network due to altered Notch3 in ovarian cancer; Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; ATM signaling in development and disease ; VEGFA-VEGFR2 signaling pathway; p38 MAPK signaling pathway; Extracellular vesicles in the crosstalk of cardiac cells; Ferroptosis; IL-18 signaling pathway; Intracellular trafficking proteins involved in CMT neuropathy",906.5,971,876,783.3,757.3,814.9,1.1689662492039907,0.22523327648295727,0.01519973395577014,1.8181640135389208,0.1255309101499706,0.9012493223527732,885]
["P04818","thymidylate synthase [OS=Homo sapiens]",15,5,6,5,313,35.7,7.01,3.92,"DNA metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","TYMS","ENSG00000176890","Pyrimidine metabolism; One carbon pool by folate; Metabolic pathways; Antifolate resistance","Interconversion of nucleotide di- and triphosphates; G1/S-Specific Transcription","Fluoropyrimidine activity; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration and one-carbon metabolism; One-carbon metabolism and related pathways; Ethanol effects on histone modifications; Pyrimidine metabolism",309.4,317.7,321.5,583.7,632.5,590.8,0.5249584947426673,-0.9297247326724352,5.2448883776591755E-5,4.280263750079102,0.010648580320086365,1.9727082889624163,36]
["P04839","Cytochrome b-245 heavy chain [OS=Homo sapiens]",4,2,4,2,570,65.3,8.63,5.85,"other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","CYBB","ENSG00000165168","HIF-1 signaling pathway; Phagosome; Ferroptosis; Necroptosis; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Leukocyte transendothelial migration; AGE-RAGE signaling pathway in diabetic complications; Alzheimer disease; Prion disease; Pathways of neurodegeneration; Leishmaniasis; Coronavirus disease; Diabetic cardiomyopathy; Lipid and atherosclerosis","Neutrophil degranulation; RAC2 GTPase cycle; RAC3 GTPase cycle; RAC1 GTPase cycle; Detoxification of Reactive Oxygen Species; VEGFA-VEGFR2 Pathway; ROS and RNS production in phagocytes; Cross-presentation of particulate exogenous antigens (phagosomes); RHO GTPases Activate NADPH Oxidases","Alzheimer's disease and miRNA effects; VEGFA-VEGFR2 signaling pathway; Microglia pathogen phagocytosis pathway; Oxidative stress response; Ferroptosis; Alzheimer's disease; Type II interferon signaling (IFNG)",674.1,588.3,552,525.6,510.7,422.4,1.2438472612600262,0.3148093400091298,0.07066630387205691,1.1507876234149892,0.26378958886663123,0.5787423489981354,1958]
["P04843","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [OS=Homo sapiens]",63,36,375,36,607,68.5,6.38,1108.82,"protein metabolism;other metabolic processes","other membranes;cytosol;ER/Golgi;other cell component","","RPN1","ENSG00000163902","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum","SRP-dependent cotranslational protein targeting to membrane; Asparagine N-linked glycosylation; Maturation of spike protein","Proteasome degradation",47148.5,46918.2,47445.2,41985.2,41427.5,36981.5,1.1754046291266522,0.23315748525392185,0.011458960071521567,1.9408547938601326,0.11078510471263378,0.9555186274773662,756]
["P04844-1","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [OS=Homo sapiens]",52,22,187,1,631,69.2,5.69,634.88,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus;other cytoplasmic organelle","translation activity","RPN2","ENSG00000118705","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum","SRP-dependent cotranslational protein targeting to membrane; Asparagine N-linked glycosylation; Maturation of spike protein","Proteasome degradation",555.1,532.8,473,395.3,382.7,127.3,1.7241798298906443,0.7859102536389261,0.07356876756003525,1.1333065192920013,0.2688570610481488,0.5704785530720095,2000]
["P04844-2","Isoform 2 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [OS=Homo sapiens]",49,22,161,1,615,67.7,6.06,563.89,"","","","RPN2","","","","",13200.2,14162.5,14027.8,11247,10539,9175.7,1.336829050084459,0.41881498946731466,0.006858858165576708,2.163748177830282,0.08628467182822747,1.06406634833664,581]
["P04899-1","guanine nucleotide-binding protein G(i) subunit alpha-2 [OS=Homo sapiens]",60,16,67,9,355,40.4,5.54,231.53,"cell-cell signaling;cell cycle OR cell proliferation;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","GNAI2","ENSCANG00000029469; ENSCATG00000043630; ENSCSAG00000014329; ENSG00000114353; ENSMFAG00000032665; ENSMMUG00000056280; ENSMNEG00000033996; ENSNLEG00000006962; ENSPANG00000023235; ENSPTRG00000014951; ENSRBIG00000038900; ENSRROG00000029350; ENSTSYG00000005938","Rap1 signaling pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Adrenergic signaling in cardiomyocytes; Axon guidance; Apelin signaling pathway; Gap junction; Platelet activation; Leukocyte transendothelial migration; Circadian entrainment; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; GABAergic synapse; Dopaminergic synapse; Long-term depression; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Melanogenesis; Oxytocin signaling pathway; Regulation of lipolysis in adipocytes; Renin secretion; Relaxin signaling pathway; Parathyroid hormone synthesis, secretion and action; Cushing syndrome; Growth hormone synthesis, secretion and action; Gastric acid secretion; Parkinson disease; Cocaine addiction; Morphine addiction; Alcoholism; Pertussis; Chagas disease; Toxoplasmosis; Human cytomegalovirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Chemical carcinogenesis","G alpha (i) signalling events; G alpha (z) signalling events; Adenylate cyclase inhibitory pathway; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; ADORA2B mediated anti-inflammatory cytokines production; Adrenaline,noradrenaline inhibits insulin secretion","Thyroid stimulating hormone (TSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; S1P receptor signal transduction; Complement system; G protein signaling pathways; Chemokine signaling pathway; Hippo signaling regulation pathways; Purinergic signaling; Calcium regulation in cardiac cells; Calcium regulation in cardiac cells",8649,8417.1,8273.6,7375.3,6896.3,7728.2,1.15181501650015,0.20390903604497349,0.01363366802247078,1.8653872852065938,0.12063980578237159,0.9185093706430031,826]
["P04920-1","Anion exchange protein 2 [OS=Homo sapiens]",26,23,59,23,1241,136.9,6.29,248.64,"transport;developmental processes;other biological processes","plasma membrane;other membranes","transporter activity;other molecular function","SLC4A2","ENSG00000164889","Salivary secretion; Gastric acid secretion; Pancreatic secretion; Bile secretion","Bicarbonate transporters","Proximal tubule transport",4216.6,4101.4,4131.8,3627.6,3698.9,4072.9,1.0921452006245944,0.12716467520944044,0.06968989489335294,1.1568301904847118,0.26188351762237355,0.5818918342624655,1945]
["P04921-1","Glycophorin-C [OS=Homo sapiens]",27,2,4,2,128,13.8,4.84,19.82,"","plasma membrane;other membranes;cytoskeleton","","GYPC","ENSG00000136732","Malaria","Cell surface interactions at the vascular wall","",395.6,390.3,434.4,441.9,473,758.7,0.7291467495219885,-0.4557188914447178,0.21179358125667086,0.6740872060181933,0.44765739890254697,0.3490542330721241,3458]
["P05023","Sodium/potassium-transporting ATPase subunit alpha-1 [OS=Homo sapiens]",46,42,245,42,1023,112.8,5.49,823.18,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;cytoskeletal activity;other molecular function","ATP1A1","ENSG00000163399","cGMP-PKG signaling pathway; cAMP signaling pathway; Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Insulin secretion; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Aldosterone synthesis and secretion; Aldosterone-regulated sodium reabsorption; Endocrine and other factor-regulated calcium reabsorption; Proximal tubule bicarbonate reclamation; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Carbohydrate digestion and absorption; Protein digestion and absorption; Bile secretion; Mineral absorption","Ion homeostasis; Ion transport by P-type ATPases; Potential therapeutics for SARS","Pre-implantation embryo; Proximal tubule transport",27011.5,26681.1,26426.3,20977.8,21878.1,23742.2,1.2030208068998967,0.26666159492604824,0.005615129267812659,2.2506402412455317,0.07772912844402032,1.109416201895371,528]
["P05026","Sodium/potassium-transporting ATPase subunit beta-1 [OS=Homo sapiens]",8,3,5,3,303,35,8.53,5.59,"cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","transporter activity;other molecular function","ATP1B1","ENSG00000143153","cGMP-PKG signaling pathway; cAMP signaling pathway; Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Insulin secretion; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Aldosterone synthesis and secretion; Aldosterone-regulated sodium reabsorption; Endocrine and other factor-regulated calcium reabsorption; Proximal tubule bicarbonate reclamation; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Carbohydrate digestion and absorption; Protein digestion and absorption; Bile secretion; Mineral absorption","Ion homeostasis; Ion transport by P-type ATPases; Potential therapeutics for SARS; Basigin interactions","Proximal tubule transport; Calcium regulation in cardiac cells",558.9,562.7,601.4,505,511.5,626.3,1.0488190893596299,0.06876584913325473,0.5560718008187704,0.2548691280472174,0.6877036873408447,0.16259864704449983,5910]
["P05062","fructose-bisphosphate aldolase B [OS=Homo sapiens]",6,3,32,1,364,39.4,7.87,72.4,"cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;cytoskeleton","cytoskeletal activity;other molecular function","ALDOB","ENSG00000136872","Glycolysis / Gluconeogenesis; Pentose phosphate pathway; Fructose and mannose metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; HIF-1 signaling pathway","Glycolysis; Gluconeogenesis; Fructose catabolism; Hereditary fructose intolerance","Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Glycolysis and gluconeogenesis; Polyol pathway",43.6,37.7,43.2,37,39.8,83.7,0.7757009345794393,-0.36642755505422203,0.47510807981076425,0.32320758379381925,0.6294299357144962,0.20105260586758625,5517]
["P05067-1","Amyloid-beta A4 protein [OS=Homo sapiens]",13,8,19,8,770,86.9,4.82,63.9,"cell adhesion;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function","APP","ENSG00000142192","Serotonergic synapse; Alzheimer disease; Pathways of neurodegeneration","Amyloid fiber formation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Platelet degranulation ; G alpha (q) signalling events; G alpha (i) signalling events; ECM proteoglycans; Lysosome Vesicle Biogenesis; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; TRAF6 mediated NF-kB activation; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Formyl peptide receptors bind formyl peptides and many other ligands; Advanced glycosylation endproduct receptor signaling","Alzheimer's disease and miRNA effects; Endoderm differentiation; Apoptosis-related network due to altered Notch3 in ovarian cancer; Copper homeostasis; TGF-beta signaling pathway; Fragile X syndrome; Inclusion body myositis; Alzheimer's disease",2101.2,2055.3,2139.4,2191.8,2379.7,2105.2,0.9429658364161936,-0.08472259177677778,0.20785483825092577,0.6822398619385037,0.4436948051331823,0.3529156560596464,3424]
["P05089","Arginase-1 [OS=Homo sapiens]",7,2,2,2,322,34.7,7.21,2.25,"other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","ARG1","ENSG00000118520","Arginine biosynthesis; Arginine and proline metabolism; Metabolic pathways; Biosynthesis of amino acids; Amoebiasis","Neutrophil degranulation; Urea cycle","Spinal cord injury; Amino acid metabolism; IL-18 signaling pathway",137.1,230.6,156.6,165.7,189,171.5,0.9963892056252375,-5.2187026495341855E-3,0.9838048775386725,7.0910286125487575E-3,0.990035777217425,4.3491108899710775E-3,7263]
["P05091","Aldehyde dehydrogenase, mitochondrial [OS=Homo sapiens]",4,2,2,1,517,56.3,7.05,6.5,"other metabolic processes","mitochondrion","other molecular function","ALDH2","ENSG00000111275","Glycolysis / Gluconeogenesis; Ascorbate and aldarate metabolism; Fatty acid degradation; Valine, leucine and isoleucine degradation; Lysine degradation; Arginine and proline metabolism; Histidine metabolism; Tryptophan metabolism; beta-Alanine metabolism; Glycerolipid metabolism; Pyruvate metabolism; Pantothenate and CoA biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Alcoholic liver disease","Ethanol oxidation; Metabolism of serotonin","Fatty acid omega-oxidation; Ethanol effects on histone modifications; Tryptophan metabolism; Fluoroacetic acid toxicity",66,78.3,80.4,84,84.5,61.8,0.9756838905775077,-0.03551428661293819,0.8411205383763616,0.07514176234651718,0.8977438690118029,0.04684755213164106,6848]
["P05114","Non-histone chromosomal protein HMG-14 [OS=Homo sapiens]",51,6,23,6,100,10.7,9.6,67.88,"cell organization and biogenesis;DNA metabolism;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HMGN1","ENSG00000205581","","Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER","ATM signaling in development and disease ; p38 MAPK signaling pathway; Malignant pleural mesothelioma; Nucleotide excision repair in xeroderma pigmentosum",2928.2,3332.8,2949.2,2531,2860.3,1567.3,1.3235708332135776,0.40443540525375116,0.14086149196364967,0.8512077159994252,0.3687523799291961,0.4332651680665758,2792]
["P05141","ADP/ATP translocase 2 [OS=Homo sapiens]",52,18,249,5,298,32.8,9.69,692.48,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion","transporter activity;other molecular function","SLC25A5","ENSG00000005022","Calcium signaling pathway; cGMP-PKG signaling pathway; Necroptosis; Cellular senescence; Neutrophil extracellular trap formation; Alzheimer disease; Parkinson disease; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Influenza A; Human T-cell leukemia virus 1 infection; Chemical carcinogenesis; Diabetic cardiomyopathy","Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization","Electron transport chain: OXPHOS system in mitochondria; Alzheimer's disease and miRNA effects; Alzheimer's disease",39344,39358.1,38726.5,35261.3,33767.1,49370.8,0.991802309475064,-0.01187551012446235,0.9512720723654062,0.02169525316982098,0.9710680973350215,0.012750313593703579,7160]
["P05161","Ubiquitin-like protein ISG15 [OS=Homo sapiens]",10,2,3,2,165,17.9,7.44,6.18,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;cytosol;translational apparatus;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ISG15","ENSG00000187608","RIG-I-like receptor signaling pathway; Human papillomavirus infection; Epstein-Barr virus infection; Coronavirus disease","Interferon alpha/beta signaling; ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling","Novel intracellular components of RIG-I-like receptor (RLR) pathway; Non-genomic actions of 1,25 dihydroxyvitamin D3; Cytosolic DNA-sensing pathway; p53 transcriptional gene network; Type II interferon signaling (IFNG)",302.6,343.1,323.4,298.1,264.3,156.3,1.3484068456936134,0.43125585683639034,0.13285137091331,0.876633959680397,0.3587036091634218,0.4452642535669305,2707]
["P05165-1","Propionyl-CoA carboxylase alpha chain, mitochondrial [OS=Homo sapiens]",28,16,30,16,728,80,7.52,89.32,"other metabolic processes","cytosol;mitochondrion","other molecular function","PCCA","ENSG00000175198","Valine, leucine and isoleucine degradation; Glyoxylate and dicarboxylate metabolism; Propanoate metabolism; Metabolic pathways; Carbon metabolism","Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency; Propionyl-CoA catabolism","",2604.3,2497,2503.2,2367.7,2313.9,2650.3,1.0371799942716078,0.052666284034761056,0.4550914548422889,0.34190131907431925,0.6144953710405117,0.21148138428140761,5413]
["P05166-1","propionyl-CoA carboxylase beta chain, mitochondrial [OS=Homo sapiens]",21,9,15,9,539,58.2,7.64,54.36,"other metabolic processes","cytosol;mitochondrion","other molecular function","PCCB","ENSG00000114054","Valine, leucine and isoleucine degradation; Glyoxylate and dicarboxylate metabolism; Propanoate metabolism; Metabolic pathways; Carbon metabolism","Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency; Propionyl-CoA catabolism","",1666.8,1665.9,1673.8,1562.6,1517.8,1395.8,1.1184710245297351,0.1615278819591848,0.02396578629786411,1.6204083175913866,0.15298334676950986,0.8153558423833203,1145]
["P05198","Eukaryotic translation initiation factor 2 subunit 1 [OS=Homo sapiens]",66,20,221,20,315,36.1,5.08,697.51,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;translational apparatus;nucleus;other cell component","translation activity;nucleic acid binding activity","EIF2S1","ENSG00000134001","Autophagy; Protein processing in endoplasmic reticulum; Apoptosis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Prion disease; Pathways of neurodegeneration; Hepatitis C; Measles; Influenza A; Herpes simplex virus 1 infection; Lipid and atherosclerosis","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency","Translation factors; Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; Ebola virus pathway in host; Nonalcoholic fatty liver disease; Unfolded protein response; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; Alzheimer's disease",18653.2,19335,19620.4,17837,17392,15061,1.1455279379598329,0.19601264455668152,0.05473772603364484,1.261713248423029,0.2316607061840823,0.6351476241065147,1727]
["P05204","Non-histone chromosomal protein HMG-17 [OS=Homo sapiens]",16,2,9,2,90,9.4,9.99,21.42,"cell organization and biogenesis;other biological processes","non-structural extracellular;nucleus;other cell component","nucleic acid binding activity;other molecular function","HMGN2","ENSG00000198830","","","",1510.9,2172.5,1869.8,1221.9,1158.2,975.8,1.6547572931255399,0.7266196293094124,0.023296306816346125,1.6327129225967691,0.1512190999295505,0.8203933512281235,1126]
["P05362","Intercellular adhesion molecule 1 [OS=Homo sapiens]",24,9,19,9,532,57.8,7.99,72.98,"cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","ICAM1","ENSG00000090339","NF-kappa B signaling pathway; Cell adhesion molecules; Natural killer cell mediated cytotoxicity; TNF signaling pathway; Leukocyte transendothelial migration; AGE-RAGE signaling pathway in diabetic complications; African trypanosomiasis; Malaria; Staphylococcus aureus infection; Influenza A; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Rheumatoid arthritis; Viral myocarditis; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","Interleukin-4 and Interleukin-13 signaling; Interferon gamma signaling; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Integrin cell surface interactions; Interleukin-10 signaling","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; RANKL/RANK signaling pathway; Interleukin-11 signaling pathway; Spinal cord injury; Complement system; IL1 and megakaryocytes in obesity; Photodynamic therapy-induced NF-kB survival signaling; VEGFA-VEGFR2 signaling pathway; miRNAs involvement in the immune response in sepsis; Cells and molecules involved in local acute inflammatory response ; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; CAMKK2 pathway; p53 transcriptional gene network; Orexin receptor pathway; Type II interferon signaling (IFNG)",2269.5,2252.5,2276.8,2336.2,2363.9,1999.8,1.0147614143494679,0.02114056800580246,0.7925191950536541,0.10099021023964046,0.8608296621559158,0.06508277665829768,6729]
["P05386","60S acidic ribosomal protein P1 [OS=Homo sapiens]",57,3,24,3,114,11.5,4.32,86.06,"protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus","enzyme regulator activity;other molecular function","RPLP1","ENSG00000137818","Ribosome; Coronavirus disease","L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",2567.7,2323.5,2607.2,3507.1,3955.9,3739.2,0.6693685168984663,-0.5791273980347046,1.4147438123493208E-3,2.849322196857856,0.041033184620877725,1.3868647757554273,252]
["P05455","Lupus La protein [OS=Homo sapiens]",70,34,273,34,408,46.8,7.12,717.54,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","nucleus;other cell component","nucleic acid binding activity","SSB","ENSG00000138385","Systemic lupus erythematosus","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination","",37031.2,37464.5,38642.4,38798.5,38169.2,27350.4,1.0845490859208518,0.11709534984008539,0.4764963925486385,0.3219403829630117,0.6309261110757245,0.2000214988082376,5520]
["P06213-1","insulin receptor [OS=Homo sapiens]",10,12,19,11,1382,156.2,6.2,54.6,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","INSR","ENSG00000171105","MAPK signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cGMP-PKG signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Phospholipase D signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Adherens junction; Insulin signaling pathway; Ovarian steroidogenesis; Regulation of lipolysis in adipocytes; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; Aldosterone-regulated sodium reabsorption; Alzheimer disease; Diabetic cardiomyopathy","PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Insulin receptor recycling; IRS activation; Signal attenuation","AMP-activated protein kinase (AMPK) signaling; Selenium micronutrient network; Vitamin B12 metabolism; Type II diabetes mellitus; Folate metabolism; Alzheimer's disease and miRNA effects; AGE/RAGE pathway; Nanoparticle triggered autophagic cell death; Transcription factor regulation in adipogenesis; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; PI3K-Akt signaling pathway; Ras signaling; NRF2-ARE regulation; Nonalcoholic fatty liver disease; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Male infertility; Insulin signaling; 16p11.2 distal deletion syndrome; Neuroinflammation and glutamatergic signaling; Malignant pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)",1704.1,1752.3,1724.2,1830.5,1811.1,1720.2,0.9662053787907046,-0.049598210723172664,0.17570045807854076,0.7552271062296726,0.40897918729173705,0.38829879241891463,3140]
["P06396","Gelsolin [OS=Homo sapiens]",10,8,12,8,782,85.6,6.28,27.52,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","GSN","ENSG00000148180","Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Viral carcinogenesis","Neutrophil degranulation; Amyloid fiber formation; Sensory processing of sound by outer hair cells of the cochlea; Caspase-mediated cleavage of cytoskeletal proteins","Ebola virus pathway in host; Regulation of actin cytoskeleton; Senescence and autophagy in cancer",1715.1,1665,1714.3,1461.6,1570.1,1354.6,1.1614344664067666,0.21590775280599248,0.021460187450022365,1.6683664888866194,0.14618127686133595,0.8351082489685975,1073]
["P06737-1","Glycogen phosphorylase, liver form [OS=Homo sapiens]",8,7,11,4,847,97.1,7.17,27.47,"other metabolic processes;other biological processes","non-structural extracellular;cytosol;other cell component","other molecular function","PYGL","ENSG00000100504; ENSPPAG00000035478; ENSPTRG00000006337","Starch and sucrose metabolism; Metabolic pathways; Necroptosis; Insulin signaling pathway; Glucagon signaling pathway; Insulin resistance","Neutrophil degranulation; Glycogen breakdown (glycogenolysis)","TNF-alpha signaling pathway; Glycogen synthesis and degradation; Glycogen metabolism",128.7,160.4,152.5,136.8,136.6,233.9,0.8704908338261385,-0.20009898835297027,0.5520269836793895,0.2580396929652934,0.6859512451058583,0.1637067512523709,5882]
["P06858","lipoprotein lipase [OS=Homo sapiens]",1,1,1,1,475,53.1,8.15,1.76,"cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","LPL","ENSG00000175445","Glycerolipid metabolism; PPAR signaling pathway; Cholesterol metabolism; Alzheimer disease","Transcriptional regulation of white adipocyte differentiation; Retinoid metabolism and transport; Assembly of active LPL and LIPC lipase complexes; Chylomicron remodeling","Fatty acid beta-oxidation; Sterol regulatory element-binding proteins (SREBP) signaling; Alzheimer's disease and miRNA effects; Adipogenesis; Aryl hydrocarbon receptor Netpath; Triacylglyceride synthesis; Lipid particles composition; Angiopoietin-like protein 8 regulatory pathway; PPAR signaling pathway; Statin inhibition of cholesterol production; Metabolic pathway of LDL, HDL and TG, including diseases; Overview of leukocyte-intrinsic Hippo pathway functions; Orexin receptor pathway; Familial partial lipodystrophy (FPLD); Familial  hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5; Alzheimer's disease; Vitamin A and carotenoid metabolism",73.2,86.3,76.6,78.7,91.2,91,0.9049444231506326,-0.1440989025888092,0.2205930840516662,0.6564081075136033,0.45430116971925283,0.3426561449772232,3549]
["P07099","epoxide hydrolase 1 [OS=Homo sapiens]",39,15,66,15,455,52.9,7.25,209.82,"other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","EPHX1","ENSG00000143819","Metabolism of xenobiotics by cytochrome P450; Bile secretion; Chemical carcinogenesis; Chemical carcinogenesis; Chemical carcinogenesis","Phase I - Functionalization of compounds","Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Benzene metabolism; Benzo(a)pyrene metabolism; Aflatoxin B1 metabolism; Metapathway biotransformation Phase I and II",7905.3,7982.7,7991.9,6094.4,6182.6,6299.1,1.2855174121586341,0.36234915141216445,1.1087775031485857E-5,4.955155594382293,0.005788610550366438,2.2374256681765576,14]
["P07311","Acylphosphatase-1 [OS=Homo sapiens]",26,3,5,3,99,11.3,9.31,14.66,"other metabolic processes","","other molecular function","ACYP1","ENSG00000119640","Pyruvate metabolism; Metabolic pathways","","",785.8,775.9,770.5,783.2,854.7,1004.2,0.8827069376632223,-0.17999355821155422,0.18862366771289205,0.7244038147152679,0.4225100788579614,0.3741629266191699,3263]
["P07384","Calpain-1 catalytic subunit [OS=Homo sapiens]",57,35,159,34,714,81.8,5.67,466.75,"protein metabolism;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","CAPN1","ENSG00000014216","Protein processing in endoplasmic reticulum; Apoptosis; Necroptosis; Cellular senescence; Alzheimer disease; Pathways of neurodegeneration; Shigellosis","Degradation of the extracellular matrix; Neutrophil degranulation; Formation of the cornified envelope; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models","Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Alzheimer's disease",17031.3,17284.9,17268.3,15734.6,15584.8,15426,1.103520346387024,0.1421132298540934,1.8321429262479344E-4,3.7370406498496096,0.015754273703466062,1.8026016136799297,85]
["P07741-1","Adenine phosphoribosyltransferase [OS=Homo sapiens]",74,12,84,12,180,19.6,6.02,249.53,"other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","APRT","ENSG00000198931; ENSPPAG00000005769; ENSPTRG00000008466","Purine metabolism; Metabolic pathways","Neutrophil degranulation; Purine salvage","",9837.8,10211.8,10639.4,9085.2,8850.8,9965.6,1.0999010809415948,0.13737378152075638,0.08652872333303674,1.0628397039298025,0.2929311898291642,0.5332343843800604,2159]
["P07992-1","DNA excision repair protein ERCC-1 [OS=Homo sapiens]",15,3,3,3,297,32.5,6.25,10.09,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ERCC1","ENSG00000012061; ENSPPAG00000043568; ENSPTRG00000011152","Platinum drug resistance; Nucleotide excision repair; Fanconi anemia pathway","HDR through Single Strand Annealing (SSA); Fanconi Anemia Pathway; Dual incision in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER","Male infertility; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum",213.2,258.6,253.7,246.1,246.8,166.7,1.0999090357792602,0.13738421551663982,0.5076456716332566,0.2944393124125855,0.6532363052759634,0.18492968623963138,5680]
["P08069","Insulin-like growth factor 1 receptor [OS=Homo sapiens]",3,4,5,3,1367,154.7,5.8,12.45,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;transporter activity;kinase activity;other molecular function","IGF1R","ENSG00000140443","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; Ras signaling pathway; Rap1 signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Oocyte meiosis; Autophagy; Endocytosis; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Focal adhesion; Adherens junction; Signaling pathways regulating pluripotency of stem cells; Long-term depression; Ovarian steroidogenesis; Progesterone-mediated oocyte maturation; Pathways in cancer; Transcriptional misregulation in cancer; Proteoglycans in cancer; Glioma; Prostate cancer; Melanoma; Breast cancer; Hepatocellular carcinoma","Extra-nuclear estrogen signaling; IRS-related events triggered by IGF1R; Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R); SHC-related events triggered by IGF1R","MicroRNAs in cardiomyocyte hypertrophy; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Apoptosis; Focal adhesion; MECP2 and associated Rett syndrome; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Ebola virus pathway in host; Ras signaling; Breast cancer pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Head and neck squamous cell carcinoma; Endochondral ossification; EGFR tyrosine kinase inhibitor resistance; Endochondral ossification with skeletal dysplasias; Insulin signaling; Malignant pleural mesothelioma; Senescence and autophagy in cancer",255.4,249.2,269.4,268.1,282.5,241.7,0.9769026883756154,-0.03371323585647624,0.6715972959700056,0.1728910611159864,0.7732679011097623,0.11167001731482404,6348]
["P08237","ATP-dependent 6-phosphofructokinase, muscle type [OS=Homo sapiens]",48,27,99,24,780,85.1,7.99,319.74,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus","kinase activity;other molecular function","PFKM","ENSG00000152556","Glycolysis / Gluconeogenesis; Pentose phosphate pathway; Fructose and mannose metabolism; Galactose metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; RNA degradation; HIF-1 signaling pathway; AMPK signaling pathway; Thyroid hormone signaling pathway; Glucagon signaling pathway; Central carbon metabolism in cancer","Glycolysis","Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Insulin signaling; Glycolysis and gluconeogenesis",10483.8,10498.2,10829.8,10073.3,9877,9264.2,1.0889044823632101,0.12287740780624147,0.03217911960482972,1.4924258420267564,0.1781796857512882,0.7491418113486332,1320]
["P08582-1","Melanotransferrin [OS=Homo sapiens]",10,5,7,5,738,80.2,5.94,23.52,"transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","MELTF","ENSG00000163975","","Post-translational modification: synthesis of GPI-anchored proteins; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","3q29 copy number variation syndrome",482.1,503,493,398.5,444.5,603.6,1.0217751970136872,0.03107782070965768,0.8745925123088211,0.0581942451216001,0.9177884669727455,0.03725740399760946,6965]
["P08670","Vimentin [OS=Homo sapiens]",82,44,1256,40,466,53.6,5.12,3152.9,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","VIM","ENSG00000026025","Epstein-Barr virus infection; MicroRNAs in cancer","Aggrephagy; Interleukin-4 and Interleukin-13 signaling; Chaperone Mediated Autophagy; Late endosomal microautophagy; Striated Muscle Contraction; RHOBTB1 GTPase cycle; Caspase-mediated cleavage of cytoskeletal proteins","Allograft Rejection; Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Mammary gland development pathway - Puberty (Stage 2 of 4); Apoptosis-related network due to altered Notch3 in ovarian cancer; Striated muscle contraction pathway; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Ciliary landscape; Burn wound healing; CCL18 signaling pathway; T-cell receptor (TCR) signaling pathway",128525.8,127561.7,123330.6,130907,135923,127700.4,0.9616954739102488,-0.056347965789747184,0.1547275164484756,0.8104324453241144,0.3872956910006535,0.4119573348885597,2920]
["P08887-1","Interleukin-6 receptor subunit alpha [OS=Homo sapiens]",2,1,1,1,468,51.5,8.22,2.3,"other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","other molecular function","IL6R","ENSG00000160712","EGFR tyrosine kinase inhibitor resistance; Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor; HIF-1 signaling pathway; PI3K-Akt signaling pathway; JAK-STAT signaling pathway; Hematopoietic cell lineage; Th17 cell differentiation; Non-alcoholic fatty liver disease; Human cytomegalovirus infection; Coronavirus disease; Pathways in cancer","Transcriptional regulation of granulopoiesis; Potential therapeutics for SARS; Interleukin-4 and Interleukin-13 signaling; Interleukin-6 signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation","Pluripotent stem cell differentiation pathway; IL-6 signaling pathway; Hepatitis C and hepatocellular carcinoma; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Nonalcoholic fatty liver disease; Regulatory circuits of the STAT3 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Neuroinflammation and glutamatergic signaling; Senescence and autophagy in cancer; Sudden infant death syndrome (SIDS) susceptibility pathways",94.6,94,86.1,154.7,185.5,598.3,0.2927011188066063,-1.7724998346423804,0.19678667497243107,0.7060043123166042,0.4317963996918339,0.3647209831238081,3331]
["P09001","39S ribosomal protein L3, mitochondrial [OS=Homo sapiens]",47,10,38,10,348,38.6,9.48,101.96,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL3","ENSG00000114686","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",3542.5,3607.1,3608.6,3648.6,3500.9,4087.2,0.9574163232977654,-0.06278169164983755,0.4194337509818669,{"$f":"-LOG10(AA1091)","v":0.377336625669856},0.5928526950157542,{"$f":"-LOG10(AC1091)","v":0.2270532015579528},5171]
["P09493-1","Tropomyosin alpha-1 chain [OS=Homo sapiens]",28,10,53,1,284,32.7,4.74,127.27,"cell organization and biogenesis;stress response;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","TPM1","ENSG00000140416; ENSGGOG00000009130; ENSPPAG00000004536; ENSPTRG00000007141","Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; MicroRNAs in cancer; Hypertrophic cardiomyopathy; Dilated cardiomyopathy","Smooth Muscle Contraction; Striated Muscle Contraction","Vitamin D receptor pathway; Striated muscle contraction pathway",74.5,74.5,80,76.2,86.4,75.3,0.9625893232450607,-0.05500767344082864,0.49986427706101827,0.3011478991138429,0.6475554769654347,0.1887230190492174,5642]
["P09543-1","2',3'-cyclic-nucleotide 3'-phosphodiesterase [OS=Homo sapiens]",47,20,86,19,421,47.5,9.07,280.98,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;mitochondrion;other cell component","nucleic acid binding activity;other molecular function","CNP","ENSG00000173786; ENSPTRG00000009187","","","Glial cell differentiation; MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation",9792.1,9930.4,10083.1,7974.1,7824.9,8818.6,1.2107435330820224,0.27589329712461885,0.005714177190296411,2.243046296754316,0.0785054907591663,1.1050999671653914,532]
["P09651-1","Heterogeneous nuclear ribonucleoprotein A1 [OS=Homo sapiens]",68,24,322,1,372,38.7,9.13,982.14,"RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HNRNPA1; HNRPA1","ENSCANG00000041992; ENSCATG00000043560; ENSG00000135486; ENSMFAG00000031561; ENSMLEG00000044414; ENSMMUG00000012989; ENSMNEG00000042992; ENSPANG00000010434; ENSPPAG00000018027; ENSPTRG00000049417; ENSRBIG00000029387; ENSRROG00000030782","Spliceosome; Amyotrophic lateral sclerosis","mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA","mRNA processing; mRNA Processing",25544.6,22380.7,21539.1,27543.6,30740.5,37046.8,0.7286661512688961,-0.4566701201533385,0.04733687925517513,1.3248003768871128,0.2158360888808952,0.6658759373572848,1603]
["P09960-1","leukotriene A-4 hydrolase [OS=Homo sapiens]",49,28,124,28,611,69.2,6.18,365.67,"protein metabolism;other metabolic processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","LTA4H","ENSG00000111144; ENSPTRG00000005321","Arachidonic acid metabolism; Metabolic pathways","Neutrophil degranulation; Biosynthesis of protectins; Synthesis of Leukotrienes (LT) and Eoxins (EX); Biosynthesis of D-series resolvins; Biosynthesis of E-series 18(S)-resolvins; Biosynthesis of aspirin-triggered D-series resolvins; Biosynthesis of E-series 18(R)-resolvins","Eicosanoid synthesis; Eicosanoid metabolism via lipooxygenases (LOX); Prostaglandin and leukotriene metabolism in senescence",17133.5,17730.9,17766.6,15498.6,14364.9,10633.3,1.2996335512929416,0.37810489382399765,0.052682878194399166,1.2783305064930948,0.2269058083222531,0.6441543869267975,1697]
["P0CAP2-1","DNA-directed RNA polymerase II subunit GRINL1A [OS=Homo sapiens]",22,5,6,5,368,41.7,6.39,18.32,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction","nucleus;other cell component","other molecular function","POLR2M","ENSG00000255529","RNA polymerase","","",415.1,404.9,382.3,453.7,443.1,391.5,0.9332453621050997,-0.09967166101837856,0.2536211008004461,0.5958146167998684,0.48299026205066714,0.31606162531534815,3838]
["P0CG08","Golgi pH regulator B [OS=Homo sapiens]",11,3,12,3,455,52.9,9.28,50.47,"transport;developmental processes;other biological processes","other membranes;ER/Golgi","transporter activity","GPR89B","ENSG00000188092","","","",452.1,470.8,448.9,365.1,387.5,180.3,1.4704684317718941,0.5562758125724779,0.09097194660304661,1.041092512226497,0.299106593666967,0.5241740130415145,2223]
["P0DMV8","heat shock 70 kDa protein 1A [OS=Homo sapiens]",57,32,354,17,641,70,5.66,921,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","HSPA1A","ENSG00000204389; ENSG00000215328; ENSG00000234475; ENSG00000235941; ENSG00000237724","Spliceosome; MAPK signaling pathway; Protein processing in endoplasmic reticulum; Endocytosis; Longevity regulating pathway; Antigen processing and presentation; Estrogen signaling pathway; Prion disease; Legionellosis; Toxoplasmosis; Measles; Lipid and atherosclerosis","AUF1 (hnRNP D0) binds and destabilizes mRNA; Neutrophil degranulation; Regulation of HSF1-mediated heat shock response; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase; Viral RNP Complexes in the Host Cell Nucleus","Apoptosis modulation and signaling; Parkin-ubiquitin proteasomal system pathway; Nuclear receptors meta-pathway; NRF2 pathway; MAPK signaling pathway; Apoptosis modulation by HSP70; VEGFA-VEGFR2 signaling pathway",18321.1,18973,19192.8,17641.2,18213.1,12665.8,1.164195869340747,0.2193338039111521,0.2101800738407168,0.6774084597217764,0.44670141311480055,0.349982673659817,3439]
["P10114","Ras-related protein Rap-2a [OS=Homo sapiens]",50,8,41,4,183,20.6,4.82,124.75,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","RAP2A","ENSG00000125249","","","",624.4,667.4,624,533.1,554.3,508.7,1.200300733036777,0.2633959155872079,5.470160819511744E-3,2.2619999054764683,0.07673974170789125,1.11497966689202,521]
["P10412","Histone H1.4 [OS=Homo sapiens]",45,17,408,3,219,21.9,11.03,1195.29,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","H1-4","ENSG00000168298","","Formation of Senescence-Associated Heterochromatin Foci (SAHF); Apoptosis induced DNA fragmentation","Pathways affected in adenoid cystic carcinoma; Genotoxicity pathway",23682.3,20924,20450.9,19487.2,20849.3,63072.8,0.6291232993550869,-0.6685853020504203,0.4231143041876731,0.37354229226557323,0.5944910513855637,0.22585467824145425,5202]
["P10747-1","T-cell-specific surface glycoprotein CD28 [OS=Homo sapiens]",8,2,6,2,220,25.1,9.39,14.27,"developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","CD28","ENSG00000178562; ENSGGOG00000041735; ENSPPAG00000034998; ENSPTRG00000012833","Cell adhesion molecules; T cell receptor signaling pathway; Intestinal immune network for IgA production; Type I diabetes mellitus; Measles; PD-L1 expression and PD-1 checkpoint pathway in cancer; Autoimmune thyroid disease; Systemic lupus erythematosus; Rheumatoid arthritis; Allograft rejection; Graft-versus-host disease; Viral myocarditis","PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; CD28 dependent PI3K/Akt signaling; CD28 dependent Vav1 pathway; Nef mediated downregulation of CD28 cell surface expression","Allograft Rejection; T cell receptor and co-stimulatory signaling; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Control of immune tolerance by vasoactive intestinal peptide; Selective expression of chemokine receptors during T-cell polarization; Inflammatory response pathway; Cancer immunotherapy by CTLA4 blockade; Modulators of TCR signaling and T cell activation; Prostaglandin signaling; T-cell receptor (TCR) signaling pathway",754.7,815.2,834.7,745,787.5,578.1,1.1392968824031082,0.18814373910959115,0.22461269758851254,0.6485656962635568,0.4560261685206773,0.34101023514687107,3600]
["P10909-1","Clusterin [OS=Homo sapiens]",14,5,10,5,449,52.5,6.27,34.37,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","CLU","ENSG00000120885","Complement and coagulation cascades","Platelet degranulation ; Regulation of Complement cascade; Antimicrobial peptides; Terminal pathway of complement","Male infertility; Complement system in neuronal development and plasticity; Complement and coagulation cascades",722.6,694.6,698.3,558.1,559.1,681.8,1.1759310728182324,0.23380349910486822,0.06590701448934401,1.1810683609462351,0.25353387836979757,0.5959640000150911,1900]
["P11169","Solute carrier family 2, facilitated glucose transporter member 3 [OS=Homo sapiens]",4,2,2,2,496,53.9,7.2,4.48,"other metabolic processes;transport","plasma membrane;other membranes;other cell component","transporter activity;other molecular function","SLC2A3","ENSG00000059804","","Neutrophil degranulation; Cellular hexose transport; Vitamin C (ascorbate) metabolism; MECP2 regulates neuronal receptors and channels","Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced HIF-1 survival signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K/AKT/mTOR - VitD3 signaling; Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis",153.1,117.4,128.7,124.1,138,223.9,0.8213991769547325,-0.28384459315588273,0.4293295646404139,0.36720920395453965,0.598849196174959,0.2226825290542933,5240]
["P11277","Spectrin beta chain, erythrocytic [OS=Homo sapiens]",9,19,54,9,2137,246.3,5.27,150.96,"cell organization and biogenesis","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity","SPTB","ENSG00000070182","","COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins","",898.3,870.1,922.9,1072.7,1069,1293.3,0.7834934497816594,-0.352006881462026,0.03066402706648511,1.5133708104110242,0.17347010358277062,0.7607753621861166,1292]
["P11279","Lysosome-associated membrane glycoprotein 1 [OS=Homo sapiens]",19,8,56,8,417,44.9,8.75,149.71,"transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","LAMP1","ENSG00000185896","Autophagy; Lysosome; Phagosome; Tuberculosis","Neutrophil degranulation","Senescence and autophagy in cancer",6524.4,6976.1,6833.4,5392.4,5142.9,3420.5,1.4570214534458792,0.5430221200600209,0.028491769217399533,1.5452805820873947,0.16713189503208123,0.7769406625265726,1246]
["P11717","Cation-independent mannose-6-phosphate receptor [OS=Homo sapiens]",37,74,213,74,2491,274.2,5.94,668.87,"protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","IGF2R","ENSG00000197081","Lysosome; Endocytosis","Neutrophil degranulation; Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; Retrograde transport at the Trans-Golgi-Network","",22326.1,22380,22086.5,21247.2,20754,25221,0.993609254085704,-0.009249484572344821,0.9243594785129695,0.034159101102860016,0.9531805062713451,0.0208248480978814,7088]
["P11908","ribose-phosphate pyrophosphokinase 2 [OS=Homo sapiens]",54,16,99,7,318,34.7,6.61,304.64,"other metabolic processes","other cell component","kinase activity;other molecular function","PRPS2","ENSG00000101911","Pentose phosphate pathway; Purine metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids","5-Phosphoribose 1-diphosphate biosynthesis","Nucleotide metabolism",6194.9,7081.5,7139.2,5733.5,5548.9,3222.2,1.407525888338872,0.49316145774751496,0.08472915496380636,1.0719671249561051,0.2896564048786065,0.5381168639448914,2138]
["P12259","Coagulation factor V [OS=Homo sapiens]",2,4,10,4,2224,251.5,6.05,25.4,"stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","F5","ENSG00000198734","Complement and coagulation cascades","COPII-mediated vesicle transport; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Common Pathway of Fibrin Clot Formation; Cargo concentration in the ER","Blood clotting cascade; Complement and coagulation cascades",1194.2,1256.4,1279.8,849.8,919,901.3,1.3971012321635896,0.4824365603673239,4.262405545959753E-4,3.3703452317702323,0.022575305895231764,1.6463663562874957,138]
["P12956","X-ray repair cross-complementing protein 6 [OS=Homo sapiens]",67,39,511,39,609,69.8,6.64,1565.56,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","XRCC6","ENSG00000196419","Non-homologous end-joining","Neutrophil degranulation; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation; IRF3-mediated induction of type I IFN","Non-homologous end joining; DNA repair pathways, full network",53554.8,52128.9,52445.2,51563.2,50782.5,39669.3,1.1134661831496673,0.15505774299941436,0.23699962470422703,0.6252523417072477,0.4662800153332962,0.33135319791986884,3715]
["P13073","Cytochrome c oxidase subunit 4 isoform 1, mitochondrial [OS=Homo sapiens]",36,7,70,7,169,19.6,9.51,154.87,"other metabolic processes;transport;other biological processes","other membranes;cytosol;mitochondrion;nucleus","transporter activity","COX4I1","ENSG00000131143","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly",7553.8,6988.4,7894.6,8249.7,9117.7,8181.7,0.8781835759380958,-0.18740554190119746,0.06077540022798944,1.2162721724889871,0.24353475891796864,0.6134390445974116,1824]
["P13598","Intercellular adhesion molecule 2 [OS=Homo sapiens]",8,2,2,2,275,30.6,7.43,7.3,"cell adhesion","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding","ICAM2","ENSG00000108622","Cell adhesion molecules; Natural killer cell mediated cytotoxicity","Integrin cell surface interactions; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; CD209 (DC-SIGN) signaling","Complement system; Ebola virus pathway in host",437,379.4,391.6,396.1,407.2,325.5,1.0701630049610207,0.09783056161517728,0.44256009204541885,0.3540277512444699,0.6071080541966903,0.2167340055227416,5328]
["P13747","HLA class I histocompatibility antigen, alpha chain E [OS=Homo sapiens]",38,11,40,9,358,40.1,5.95,128.11,"other biological processes","plasma membrane;other membranes","","HLA-E","","","","",2004.7,1896.9,1841.3,1898.5,1966.6,1759.2,1.0210870686129832,0.03010589079990057,0.6373719256924639,0.1956070698007298,0.7476410535846925,0.1263068591715184,6231]
["P13796","Plastin-2 [OS=Homo sapiens]",79,45,1261,36,627,70.2,5.43,3790.82,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","LCP1","ENSG00000136167","","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","",148530.1,143380.6,142082.3,137380.8,136450.6,145636.5,1.0346274410985918,0.04911136130909517,0.24111815682407883,0.6177700848875691,0.4714640471447812,0.32655142004640947,3738]
["P13995","Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [OS=Homo sapiens]",38,9,47,9,350,37.9,8.73,177.98,"other metabolic processes","mitochondrion","other molecular function","MTHFD2","ENSG00000065911","One carbon pool by folate; Metabolic pathways; Biosynthesis of cofactors","Metabolism of folate and pterines","Folate metabolism; One-carbon metabolism; Trans-sulfuration and one-carbon metabolism; Nucleotide metabolism",4394.4,4515,4572.9,4830.6,5119,3691.1,0.9883876927137168,-0.016851048376303135,0.9100827386445124,0.04091912273021291,0.9439186514478134,0.02506543234350823,7047]
["P14174","Macrophage Migration inhibitory factor [OS=Homo sapiens]",32,3,25,3,115,12.5,7.88,55.83,"cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","MIF","ENSG00000240972; ENSG00000276701","Tyrosine metabolism; Phenylalanine metabolism; Metabolic pathways","Neutrophil degranulation; Cell surface interactions at the vascular wall; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","Adipogenesis; Spinal cord injury",2622.1,2608.1,2500.9,3106.4,3011.1,2404.9,0.9071505679151414,-0.14058606722483166,0.3023661333671078,0.5194668537642426,0.5231993534044013,0.2813328014060255,4224]
["P14373","Zinc finger protein RFP [OS=Homo sapiens]",13,5,6,5,513,58.5,6.21,17.27,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","TRIM27","ENSG00000204713; ENSG00000215641; ENSG00000229006; ENSG00000234495; ENSG00000237071","","Regulation of PTEN stability and activity; SUMOylation of ubiquitinylation proteins; Suppression of apoptosis","",323.2,313,344.4,445,486.3,537,0.6678471701968263,-0.5824101000102766,0.00447344643294573,2.349357758726485,0.07001374727708853,1.1548166774086244,467]
["P14678-1","Small nuclear ribonucleoprotein-associated proteins B and B' [OS=Homo sapiens]",22,7,33,7,240,24.6,11.19,98.36,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","Snrpb; SNRPB; SNRPN","ENSANAG00000024443; ENSCANG00000019461; ENSCCAG00000026002; ENSG00000125835; ENSLCNG00005019999; ENSMLEG00000022346; ENSMMUG00000010050; ENSNLEG00000029067; ENSOGAG00000016149; ENSPANG00000020362; ENSRROG00000036094; ENSSBOG00000027310","Spliceosome; Systemic lupus erythematosus","snRNP Assembly; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs","mRNA processing",3341.6,3596.7,3704.6,4194.5,3615.8,2313.5,1.0512752128647347,0.0721404012306969,0.7752814382492326,0.11054061376354199,0.8487914967291253,0.07119897988677813,6676]
["P14927","Cytochrome b-c1 complex subunit 7 [OS=Homo sapiens]",22,2,4,2,111,13.5,8.78,11.24,"other metabolic processes","other membranes;mitochondrion","","UQCRB","ENSG00000156467","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly",186.5,201,150.2,158.4,140.6,164.2,1.1608376511226253,0.21516621828623128,0.21106551726330205,0.6755827135683425,0.44728265168961284,0.3494179460517603,3449]
["P15121","aldose reductase [OS=Homo sapiens]",72,18,128,16,316,35.8,6.98,425.69,"other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","AKR1B1","ENSG00000085662","Pentose and glucuronate interconversions; Fructose and mannose metabolism; Galactose metabolism; Glycerolipid metabolism; Folate biosynthesis; Metabolic pathways","Pregnenolone biosynthesis; Fructose biosynthesis","Eicosanoid metabolism via cyclooxygenases (COX); Polyol pathway; Metapathway biotransformation Phase I and II",17625.8,18028.2,17588.5,17357.7,15029.1,12368.3,1.1896409571199704,0.25052622265823404,0.12246397011166588,0.9119916654487042,0.34760743982375375,0.4589109369419411,2575]
["P15374","Ubiquitin carboxyl-terminal hydrolase isozyme L3 [OS=Homo sapiens]",45,9,42,9,230,26.2,4.92,127.2,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","UCHL3","ENSG00000118939","","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; UCH proteinases; Neddylation","Proteasome degradation",4557.2,4091.7,4166.5,4776.4,5126.4,5348.8,0.8402659393112856,-0.2510820900857248,0.021126547040266664,1.675171478995982,0.1451258762380724,0.8382551450710383,1064]
["P15498-1","Proto-oncogene vav [OS=Homo sapiens]",45,38,162,36,845,98.3,6.62,478.58,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","enzyme regulator activity;other molecular function","VAV1","ENSG00000141968; ENSPTRG00000010378","Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Focal adhesion; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Yersinia infection; Proteoglycans in cancer; Lipid and atherosclerosis","RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC1 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated phagocytosis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; NRAGE signals death through JNK; G alpha (12/13) signalling events; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Regulation of signaling by CBL; GPVI-mediated activation cascade; Signaling by SCF-KIT; VEGFR2 mediated vascular permeability; Erythropoietin activates RAS; CD28 dependent Vav1 pathway","Prolactin signaling pathway; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL-6 signaling pathway; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; EGF/EGFR signaling pathway; Modulators of TCR signaling and T cell activation; Regulation of actin cytoskeleton; Interferon type I signaling pathways; T-cell receptor (TCR) signaling pathway; EGFR1 signaling pathway; Kit receptor signaling pathway",22378.4,22108.6,21991.2,21633.1,20300.9,16884.7,1.1302221912419008,0.17660642104024776,0.1462984370372713,0.8347603135856553,0.37651242123430134,0.42422069174872007,2840]
["P15924-1","Desmoplakin [OS=Homo sapiens]",30,80,151,80,2871,331.6,6.81,424.21,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","DSP","ENSG00000096696","Arrhythmogenic right ventricular cardiomyopathy","Neutrophil degranulation; Formation of the cornified envelope; RND3 GTPase cycle; RND1 GTPase cycle; Apoptotic cleavage of cell adhesion  proteins","Arrhythmogenic right ventricular cardiomyopathy; Lung fibrosis; Epithelial to mesenchymal transition in colorectal cancer",16413.6,18770.2,16226.4,15221.4,15465.3,16655.7,{"$f":"AVERAGE(S1282:U1282)/AVERAGE(V1282:X1282)","v":1.085922978133766},{"$f":"LOG(Y1282,2)","v":0.11892177993319109},{"$f":"TTEST(V1282:X1282,S1282:U1282,2,2)","v":0.2188909294449588},0.6597722346569227,{"$f":"AA1282*7309/AE1282","v":0.453736189255021},0.3431965807362529,3526]
["P16035","Metalloproteinase inhibitor 2 [OS=Homo sapiens]",10,2,3,2,220,24.4,7.49,10.74,"developmental processes;other biological processes","non-structural extracellular;extracellular matrix;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","TIMP2","ENSG00000035862","","Neutrophil degranulation; Activation of Matrix Metalloproteinases","Matrix metalloproteinases; Angiogenesis; IL1 and megakaryocytes in obesity; Vitamin D receptor pathway; Burn wound healing; CCL18 signaling pathway",209.5,204.3,219.3,240.2,230.6,427.5,0.7047756874095513,-0.5047639383059165,0.24083564110355904,0.618279241711537,0.4712898797392002,0.32671188597898165,3735]
["P16219","Short-chain specific acyl-CoA dehydrogenase, mitochondrial [OS=Homo sapiens]",6,2,5,2,412,44.3,7.99,12.11,"other metabolic processes","cytoskeleton;mitochondrion;nucleus","other molecular function","ACADS","ENSG00000122971","Fatty acid degradation; Valine, leucine and isoleucine degradation; beta-Alanine metabolism; Propanoate metabolism; Butanoate metabolism; Metabolic pathways; Carbon metabolism; Fatty acid metabolism","Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA","Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation; IL-18 signaling pathway",185.7,178.3,187.3,164.7,150.3,395.4,0.7760416666666666,-0.36579398025899473,0.5410213720894007,0.2667855785215989,0.6774584904234076,0.16911730994778587,5837]
["P16402","Histone H1.3 [OS=Homo sapiens]",47,17,377,5,221,22.3,11.02,1091.22,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity","H1-3","ENSG00000124575","","Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)","",13638.7,13007.5,12485.9,11628.8,12293.5,17280.9,0.9497344866418143,-0.07440385338554767,0.7229330226779367,0.14090193677018634,0.8114123867864004,0.0907583667673582,6512]
["P16619","C-C motif chemokine 3-like 1 [OS=Homo sapiens]",24,2,10,2,93,10.2,4.89,30.53,"stress response;signal transduction;other biological processes","non-structural extracellular","signal transduction activity or receptor binding","CCL3L1; CCL3L3","ENSG00000276085; ENSG00000277336; ENSG00000277768; ENSG00000277796","Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor; Chemokine signaling pathway; Toll-like receptor signaling pathway; Chagas disease; Human cytomegalovirus infection; Rheumatoid arthritis; Lipid and atherosclerosis","Chemokine receptors bind chemokines; Interleukin-10 signaling","Overview of proinflammatory and profibrotic mediators",1078,1097.9,963.5,1691.6,2014.3,2191.2,0.5323633650438352,-0.9095168002868832,0.003783760363027738,2.422076376580571,0.06584643926992795,1.1814677050944982,420]
["P16949-1","Stathmin [OS=Homo sapiens]",36,6,9,6,149,17.3,5.97,21.91,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity","LOC101348598; Stathmin; STMN1","ENSAMEG00000010298; ENSANAG00000030242; ENSBIXG00000025259; ENSBTAG00000013761; ENSCAFG00000029191; ENSCATG00000016402; ENSCCAG00000028161; ENSCHIG00000023552; ENSCJAG00000009462; ENSCSAG00000000960; ENSFCAG00000040721; ENSG00000117632; ENSGGOG00000026648; ENSLCNG00005009740; ENSMFAG00000041588; ENSMLEG00000037590; ENSMLUG00000010762; ENSMMUG00000000653; ENSMNEG00000044643; ENSNLEG00000009154; ENSOARG00000005764; ENSOGAG00000002109; ENSPANG00000010315; ENSPCTG00005008718; ENSPPAG00000038785; ENSPPYG00000001700; ENSPTRG00000000369; ENSRBIG00000033291; ENSRFEG00010003199; ENSRROG00000019821; ENSSBOG00000029102; ENSSSCG00000026257; ENSSSCG00005028094; ENSSSCG00015059883; ENSSSCG00055018660; ENSSSCG00070026240; ENSSSUG00005019081; ENSTTRG00000012495; ENSUAMG00000025721; ENSUMAG00000012809; ENSVVUG00000011613","MAPK signaling pathway; MicroRNAs in cancer","Nuclear signaling by ERBB4","MAPK signaling pathway; Microtubule cytoskeleton regulation; Retinoblastoma gene in cancer; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; EGF/EGFR signaling pathway; IL-18 signaling pathway; MAPK signaling pathway; MAPK signaling pathway",1152,1539.6,1400.1,907.4,893.1,1262.4,1.3358908224231936,0.41780210632632014,0.10718739711677454,0.9698562751320723,0.3245371522479309,0.4887355790094297,2414]
["P17096-1","High mobility group protein HMG-I/HMG-Y [OS=Homo sapiens]",48,4,8,4,107,11.7,10.32,24.83,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","HMGA1; LOC111152215","ENSAMEG00000001061; ENSCAFG00030004107; ENSCAFG00040011381; ENSCANG00000029050; ENSCATG00000042051; ENSCCAG00000024304; ENSCSAG00000009775; ENSECAG00000000734; ENSFCAG00000044104; ENSG00000137309; ENSGGOG00000025804; ENSMLEG00000042857; ENSMMUG00000019529; ENSMNEG00000005671; ENSPCTG00005015441; ENSPTRG00000040884; ENSRBIG00000030072; ENSRFEG00010017624; ENSUAMG00000015725; ENSUMAG00000010910","","Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Formation of Senescence-Associated Heterochromatin Foci (SAHF)","Adipogenesis; Adipogenesis; Pre-implantation embryo; Male infertility; 7q11.23 copy number variation syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Orexin receptor pathway; Senescence and autophagy in cancer; Adipogenesis",1128.8,1227.4,1047.7,762.8,836.2,978.3,1.3207232374966047,0.40132817610484034,0.02814743195976228,1.5505612220055205,0.16617898238602788,0.7794239048056467,1238]
["P17152","Transmembrane protein 11, mitochondrial [OS=Homo sapiens]",14,3,9,3,192,21.5,7.36,21.08,"cell organization and biogenesis","plasma membrane;other membranes;mitochondrion","","TMEM11","ENSG00000178307","","Cristae formation","",1371.1,1289.9,1308.5,1303.4,1190.6,847.1,1.1880817694771184,0.2486341327375558,0.207355360008678,0.6832847339092946,0.4432759070790955,0.35332587282191624,3419]
["P17612","cAMP-dependent protein kinase catalytic subunit alpha [OS=Homo sapiens]",37,15,43,9,351,40.6,8.79,135.85,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","kinase activity;other molecular function","PRKACA","ENSG00000072062; ENSG00000288516","Endocrine resistance; MAPK signaling pathway; Ras signaling pathway; Calcium signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Oocyte meiosis; Autophagy; Longevity regulating pathway; Longevity regulating pathway; Adrenergic signaling in cardiomyocytes; Vascular smooth muscle contraction; Wnt signaling pathway; Hedgehog signaling pathway; Apelin signaling pathway; Tight junction; Gap junction; Platelet activation; Circadian entrainment; Thermogenesis; Long-term potentiation; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; GABAergic synapse; Dopaminergic synapse; Olfactory transduction; Taste transduction; Inflammatory mediator regulation of TRP channels; Insulin signaling pathway; Insulin secretion; GnRH signaling pathway; Ovarian steroidogenesis; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Melanogenesis; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Regulation of lipolysis in adipocytes; Renin secretion; Aldosterone synthesis and secretion; Relaxin signaling pathway; Cortisol synthesis and secretion; Parathyroid hormone synthesis, secretion and action; Cushing syndrome; Growth hormone synthesis, secretion and action; Endocrine and other factor-regulated calcium reabsorption; Vasopressin-regulated water reabsorption; Salivary secretion; Gastric acid secretion; Bile secretion; Parkinson disease; Prion disease; Cocaine addiction; Amphetamine addiction; Morphine addiction; Alcoholism; Vibrio cholerae infection; Amoebiasis; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; Chemical carcinogenesis; Dilated cardiomyopathy","Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; MAPK6/MAPK4 signaling; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Interleukin-3, Interleukin-5 and GM-CSF signaling; Factors involved in megakaryocyte development and platelet production; VEGFA-VEGFR2 Pathway; RET signaling; ROBO receptors bind AKAP5; FCGR3A-mediated IL10 synthesis; Triglyceride catabolism; ADORA2B mediated anti-inflammatory cytokines production; Ion homeostasis; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; Regulation of MECP2 expression and activity; PKA activation; PKA activation in glucagon signalling; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; CD209 (DC-SIGN) signaling; Rap1 signalling; HDL assembly; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase; Loss of phosphorylation of MECP2 at T308; PKA-mediated phosphorylation of key metabolic factors","Nicotine effect on dopaminergic neurons; Sterol regulatory element-binding proteins (SREBP) signaling; Follicle stimulating hormone (FSH) signaling pathway; Microtubule cytoskeleton regulation; Dopamine metabolism; Common pathways underlying drug addiction; Complement system; Mesodermal commitment pathway; IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Mesodermal commitment pathway; G protein signaling pathways; MAPK signaling pathway; Cannabinoid receptor signaling; Lipid metabolism pathway; Ras signaling; Hedgehog signaling pathway; Thermogenesis; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Neuroinflammation and glutamatergic signaling; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways; Estrogen signaling pathway",5678.8,5778.6,5920.4,5135,5190.1,3977.9,1.2149758791861849,0.2809276724122072,0.06306571864460246,1.2002066510446772,0.2476879836504027,0.6060950622914713,1861]
["P17931","Galectin-3 [OS=Homo sapiens]",6,1,1,1,250,26.1,8.56,3.66,"RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","LGALS3","ENSG00000131981","","Neutrophil degranulation; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; Advanced glycosylation endproduct receptor signaling; RUNX2 regulates genes involved in differentiation of myeloid cells","AGE/RAGE pathway; Spinal cord injury",73,67.1,71.9,87.1,78.4,143.9,0.6851971557853912,-0.5454089319984738,0.19043558501539093,0.7202518955953394,0.4247463200724724,0.3718703750937423,3277]
["P18031","Tyrosine-protein phosphatase non-receptor type 1 [OS=Homo sapiens]",46,18,62,18,435,49.9,6.27,198.79,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","PTPN1","ENSG00000196396","Adherens junction; Insulin signaling pathway; Insulin resistance; Chemical carcinogenesis","MECP2 regulates neuronal receptors and channels; Growth hormone receptor signaling; Regulation of IFNG signaling; Regulation of IFNA signaling; Negative regulation of MET activity; Integrin signaling; PTK6 Down-Regulation","Leptin signaling pathway; Prolactin signaling pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Insulin signaling",8656.6,8050.2,7956.2,7986.6,8039.4,9097.7,0.9816627327981148,-0.026700648041334856,0.7350902699691031,0.1336593257563075,0.8195202536919118,0.08644030877079606,6556]
["P18583-5","Isoform D of Protein SON [OS=Homo sapiens]",24,37,125,6,2459,266.9,5.73,394.66,"","","","SON","","","","",12117.4,11936.6,12086,15412.3,15806,14191.3,0.795866953243367,-0.3294008223333967,3.2158540758457717E-3,2.492703666233531,0.06026840369322242,1.2199103113760572,390]
["P18827","syndecan-1 [OS=Homo sapiens]",16,5,34,5,310,32.4,4.63,131.88,"cell-cell signaling;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SDC1","ENSG00000115884","ECM-receptor interaction; Cell adhesion molecules; Malaria; Proteoglycans in cancer; Fluid shear stress and atherosclerosis","Cell surface interactions at the vascular wall; A tetrasaccharide linker sequence is required for GAG synthesis; HS-GAG biosynthesis; HS-GAG degradation; Defective B4GALT7 causes EDS, progeroid type; Defective B3GAT3 causes JDSSDHD; Defective EXT2 causes exostoses 2; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Defective B3GALT6 causes EDSP2 and SEMDJL1; Retinoid metabolism and transport; Syndecan interactions; Other interleukin signaling","",3804.7,3826,3741.8,4475.8,5044,2149.4,0.9745740924827753,-0.037156223622696216,0.916483743868276,0.037875233932443596,0.9478675086929715,0.02325236336319314,7067]
["P18850","Cyclic AMP-dependent transcription factor ATF-6 alpha [OS=Homo sapiens]",2,1,1,1,670,74.5,8.22,0,"stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","ATF6","ENSG00000118217","Protein processing in endoplasmic reticulum; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Lipid and atherosclerosis","ATF4 activates genes in response to endoplasmic reticulum  stress; ATF6 (ATF6-alpha) activates chaperone genes","Sterol regulatory element-binding proteins (SREBP) signaling; Alzheimer's disease and miRNA effects; Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling pathway; Unfolded protein response; Alzheimer's disease",29,36.2,33.1,36.4,37.6,85,0.6182389937106919,-0.6937634438311369,0.2782283357528287,0.5555986420131798,0.5042328058560439,0.2973689021368254,4033]
["P19388","DNA-directed RNA polymerases I, II, and III subunit RPABC1 [OS=Homo sapiens]",21,4,11,4,210,24.5,5.95,29.4,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR2E","ENSG00000099817","RNA polymerase; Cytosolic DNA-sensing pathway; Huntington disease","mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; RNA Polymerase I Promoter Escape; Inhibition of DNA recombination at telomere; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Viral Messenger RNA Synthesis; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM","Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway",1022.1,994.6,1075,1571.6,1482.2,1502.5,0.6785549678467176,-0.5594624058051038,1.6928690250468879E-4,3.7713766413593324,0.015275530498849015,1.816003698354009,81]
["P19397","Leukocyte surface antigen CD53 [OS=Homo sapiens]",13,4,10,4,219,24.3,7.52,23.32,"signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","CD53","ENSG00000143119","","Neutrophil degranulation","",1181.9,1213.8,1232.1,1157.8,981.6,2309.8,0.8153825406814708,-0.29445102933135897,0.5470608378909547,0.26196437368279424,0.6818669277191317,0.16630037343189275,5864]
["P19784","casein kinase II subunit alpha' [OS=Homo sapiens]",51,14,25,13,350,41.2,8.56,89.99,"cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","CSNK2A2","ENSG00000070770","Ribosome biogenesis in eukaryotes; NF-kappa B signaling pathway; Mitophagy; Wnt signaling pathway; Adherens junction; Alzheimer disease; Prion disease; Pathways of neurodegeneration; Measles; PD-L1 expression and PD-1 checkpoint pathway in cancer","ROS sensing by NFE2L2; Regulation of PTEN stability and activity; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of TP53 Activity through Phosphorylation; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Receptor Mediated Mitophagy; Condensation of Prometaphase Chromosomes; Synthesis of PC","Alzheimer's disease and miRNA effects; Allograft Rejection; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Malignant pleural mesothelioma; Alzheimer's disease",2116.5,2115.1,2213.6,1917.2,1925.8,2333.4,1.043520497377113,0.06145893894899976,0.5600344094535001,0.2517852883925784,0.6913175981583571,0.16032238759060569,5921]
["P20036","HLA class II histocompatibility antigen, DP alpha 1 chain [OS=Homo sapiens]",18,3,4,3,260,29.4,5.21,16,"stress response;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","HLA-DPA1","ENSG00000168384; ENSG00000206291; ENSG00000224103; ENSG00000228163; ENSG00000229685; ENSG00000231389; ENSG00000235844; ENSG00000236177","Phagosome; Cell adhesion molecules; Antigen processing and presentation; Hematopoietic cell lineage; Th1 and Th2 cell differentiation; Th17 cell differentiation; Intestinal immune network for IgA production; Type I diabetes mellitus; Leishmaniasis; Toxoplasmosis; Staphylococcus aureus infection; Tuberculosis; Influenza A; Human T-cell leukemia virus 1 infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Asthma; Autoimmune thyroid disease; Inflammatory bowel disease; Systemic lupus erythematosus; Rheumatoid arthritis; Allograft rejection; Graft-versus-host disease; Viral myocarditis","Downstream TCR signaling; Generation of second messenger molecules; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling","Allograft Rejection; Ebola virus pathway in host",361.2,375.7,364.4,298.3,325,639.9,0.8718334388853706,-0.19787555603953327,0.6487524981757821,0.1879209567860783,0.7560159453390929,0.12146904457848744,6272]
["P20073-1","Annexin A7 [OS=Homo sapiens]",34,16,117,16,488,52.7,5.68,287.16,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ANXA7","ENSG00000138279","Amyotrophic lateral sclerosis","","",10577.3,11118.3,11182.5,11141.7,9707.5,10186.5,1.059363893838386,0.08319824339869393,0.2555296824241534,0.5925586447884321,0.48460468314430133,0.3146123932238933,3854]
["P20340-2","Isoform 2 of Ras-related protein Rab-6A [OS=Homo sapiens]",45,11,48,1,208,23.5,5.54,102.09,"","","","RAB6A","","","","",184.5,196.3,188.8,178.9,162.4,257,0.9520307538024404,-0.07091991668855765,0.761017624808991,0.11860528505774114,0.8394623935600536,0.07599875471970939,6626]
["P20701-1","Integrin alpha-L [OS=Homo sapiens]",11,8,11,8,1170,128.7,5.63,35.18,"cell adhesion;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","ITGAL","ENSG00000005844","Rap1 signaling pathway; Cell adhesion molecules; Neutrophil extracellular trap formation; Natural killer cell mediated cytotoxicity; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Malaria; Staphylococcus aureus infection; Human T-cell leukemia virus 1 infection; Epstein-Barr virus infection; Rheumatoid arthritis; Viral myocarditis","Neutrophil degranulation; Integrin cell surface interactions; Cell surface interactions at the vascular wall; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; RUNX3 Regulates Immune Response and Cell Migration","Integrin-mediated cell adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Acute viral myocarditis; Cells and molecules involved in local acute inflammatory response ; Overview of leukocyte-intrinsic Hippo pathway functions; CCL18 signaling pathway",1287.4,1339,1353.7,1152.1,1154.8,626.2,1.3569602127441958,0.44037842030123797,0.11977221578217552,0.9216439159362468,0.34424503545101093,0.4631323142279828,2543]
["P20810-6","Isoform 6 of Calpastatin [OS=Homo sapiens]",65,41,192,1,791,84.9,5.36,471.87,"","","","CAST","","","","",20749.9,19359.1,18193.3,21697.8,22478.2,21107.5,0.893063331469667,-0.16316560738244382,0.05011861006454858,1.3000009817654183,0.2212058701460058,0.6552033523303068,1656]
["P21333-2","Isoform 2 of Filamin-A [OS=Homo sapiens]",58,114,509,103,2639,279.8,6.05,1811.48,"","","","FLNA","","","","",62807.6,62681,60443.8,48158.1,49246.1,54612.5,1.2231050930588547,0.290548370113001,6.1339262528644E-3,2.2122614497696698,0.08048988686209317,1.0942586830594256,557]
["P21359-1","Neurofibromin [OS=Homo sapiens]",3,6,6,6,2839,319.2,7.39,17.78,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","NF1","ENSG00000196712","EGFR tyrosine kinase inhibitor resistance; MAPK signaling pathway; Ras signaling pathway","Regulation of RAS by GAPs; RAS signaling downstream of NF1 loss-of-function variants","Pilocytic astrocytoma; Glioblastoma signaling pathways; Aryl hydrocarbon receptor Netpath; MECP2 and associated Rett syndrome; MAPK signaling pathway; Ras signaling; Transcription co-factors SKI and SKIL protein partners; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Melanoma; EGFR tyrosine kinase inhibitor resistance",306.1,296.8,285.5,286.4,312.5,522.7,0.7920827389443654,-0.3362769564636421,0.35873179274583766,0.44523013209955603,0.558460207279942,0.2530077668177128,4695]
["P21964-1","Catechol O-methyltransferase [OS=Homo sapiens]",44,9,29,9,271,30,5.47,77.17,"other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","COMT","ENSG00000093010","Steroid hormone biosynthesis; Tyrosine metabolism; Metabolic pathways; Dopaminergic synapse","Potential therapeutics for SARS; Methylation; Enzymatic degradation of dopamine by COMT; Enzymatic degradation of Dopamine by monoamine oxidase","Dopamine metabolism; MTHFR deficiency; 22q11.2 copy number variation syndrome; Biogenic amine synthesis; Estrogen metabolism; Metapathway biotransformation Phase I and II; Methylation pathways",3258.3,3450.2,3484.1,3229.1,3047.8,2946,1.1051404655802406,0.14422975071800564,0.04089920828941075,1.3882850988109483,0.19836251717803793,0.7025403892416072,1507]
["P22304","iduronate 2-sulfatase [OS=Homo sapiens]",9,3,6,3,550,61.8,5.45,24.23,"other metabolic processes","other cytoplasmic organelle","other molecular function","IDS","ENSG00000010404","Glycosaminoglycan degradation; Metabolic pathways; Lysosome","HS-GAG degradation; CS/DS degradation; MPS II - Hunter syndrome","Glycosaminoglycan degradation",235.5,221,223.2,212.4,249.1,432.3,0.7604609532333856,-0.3950539219182136,0.3541937760155493,0.450759074613622,0.5550605293519832,0.2556596544806067,4664]
["P22392-2","Isoform 3 of Nucleoside diphosphate kinase B [OS=Homo sapiens]",81,15,248,2,267,30.1,8.92,730.63,"","","","NME2","","","","",39410.8,37444.8,38330.6,42051.2,38268.9,30943.6,1.0352540855642947,0.04998489622309352,0.7129576308012451,0.14693627836126769,0.8039196734844647,0.09478734317348589,6482]
["P22695","Cytochrome b-c1 complex subunit 2, mitochondrial [OS=Homo sapiens]",48,17,119,17,453,48.4,8.63,367.02,"protein metabolism;other metabolic processes;other biological processes","other membranes;mitochondrion;nucleus","other molecular function","UQCRC2","ENSG00000140740","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly",13659.3,14292.6,14216.8,12580.4,11553.9,12864,1.1397469613468725,0.18871356287177923,0.017978655787555108,1.7452427823397592,0.13603105088120113,0.8663619468712797,966]
["P23229-1","integrin alpha-6 [OS=Homo sapiens]",2,2,2,2,1130,126.5,6.61,6.6,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","ITGA6","ENSG00000091409","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Cell adhesion molecules; Hematopoietic cell lineage; Regulation of actin cytoskeleton; Toxoplasmosis; Human papillomavirus infection; Pathways in cancer; Small cell lung cancer; Hypertrophic cardiomyopathy; Arrhythmogenic right ventricular cardiomyopathy; Dilated cardiomyopathy","Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; Syndecan interactions; Laminin interactions; Basigin interactions; Type I hemidesmosome assembly","Integrin-mediated cell adhesion; Arrhythmogenic right ventricular cardiomyopathy; Alpha 6 beta 4 signaling pathway; Mammary gland development pathway - Embryonic development (Stage 1 of 4); Focal adhesion; Regulation of apoptosis by parathyroid hormone-related protein; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ebola virus pathway in host; Small cell lung cancer; Malignant pleural mesothelioma",118.8,114.6,106.8,127.8,131.9,155.5,0.8193641618497108,-0.28742330269449606,0.05509166312187344,1.2589141168307085,0.23248554604952248,0.6336040426280634,1732]
["P23284","peptidyl-prolyl cis-trans isomerase B [OS=Homo sapiens]",64,18,453,16,216,23.7,9.41,1131.48,"protein metabolism;other metabolic processes;developmental processes;other biological processes","ER/Golgi;nucleus;other cell component","other molecular function","PPIB","ENSG00000166794","","Collagen biosynthesis and modifying enzymes","Prolactin signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta",69764,71668.2,72693.6,68583.8,66200.7,65807.1,1.0674714195409978,0.0941974436739173,0.02089064026791921,1.6800482493177735,0.14486687829053274,0.8390308983103283,1054]
["P23434","Glycine cleavage system H protein, mitochondrial [OS=Homo sapiens]",39,3,11,3,173,18.9,4.88,37.11,"protein metabolism;other metabolic processes","mitochondrion;other cell component","other molecular function","GCSH","ENSG00000140905","Glycine, serine and threonine metabolism; Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism","Glycine degradation","",979.4,934.6,861.1,931.4,933.5,597,1.1272188147365856,0.1727675974030481,0.42271061948230293,0.3739568415378313,0.5942665739173211,0.22601869708743774,5199]
["P23468-1","Receptor-type tyrosine-protein phosphatase delta [OS=Homo sapiens]",2,2,2,2,1912,214.6,6.57,8.19,"cell adhesion;cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","PTPRD","ENSG00000153707; ENSG00000282932","","Synaptic adhesion-like molecules; Receptor-type tyrosine-protein phosphatases","",35.5,38.6,34.3,32.4,41.1,51,0.8706827309236947,-0.1997809856015718,0.38627932438486184,0.4130985368613122,0.5731456723363693,0.2417349824804237,4926]
["P23634-1","Plasma membrane calcium-transporting ATPase 4 [OS=Homo sapiens]",21,20,33,10,1241,137.8,6.6,122.21,"stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","transporter activity;enzyme regulator activity;other molecular function","ATP2B4","ENSG00000058668","Calcium signaling pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Adrenergic signaling in cardiomyocytes; Aldosterone synthesis and secretion; Endocrine and other factor-regulated calcium reabsorption; Salivary secretion; Pancreatic secretion; Mineral absorption","Ion homeostasis; Ion transport by P-type ATPases; Reduction of cytosolic Ca++ levels","Vitamin D-sensitive calcium signaling in depression",899.2,950.9,968.7,769.9,845.3,698.4,1.2183609958506225,0.2849416617822354,0.023511356366098198,1.6287223157785014,0.15140484905710286,0.8198602154236698,1135]
["P24539","ATP synthase F(0) complex subunit B1, mitochondrial [OS=Homo sapiens]",43,12,65,12,256,28.9,9.36,184.57,"other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","ATP5PB","ENSG00000116459","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation",7616,7115.9,7707.9,6015.5,6791.4,6791.5,1.144981222956976,0.19532393913533833,0.04057114548298456,1.391782730281467,0.19795360636524306,0.7034365817609416,1498]
["P24752","Acetyl-CoA acetyltransferase, mitochondrial [OS=Homo sapiens]",64,25,217,25,427,45.2,8.85,726.81,"other metabolic processes;stress response;developmental processes;other biological processes","mitochondrion","other molecular function","ACAT1","ENSG00000075239","Fatty acid degradation; Valine, leucine and isoleucine degradation; Lysine degradation; Tryptophan metabolism; Pyruvate metabolism; Glyoxylate and dicarboxylate metabolism; Butanoate metabolism; Terpenoid backbone biosynthesis; Metabolic pathways; Carbon metabolism; Fatty acid metabolism; Fat digestion and absorption","Branched-chain amino acid catabolism; Utilization of Ketone Bodies; Synthesis of Ketone Bodies","Fatty acid beta-oxidation; Ketone bodies synthesis and degradation; Tryptophan metabolism; SARS-CoV-2 and COVID-19 pathway",28748.3,26863.9,26376.4,25531.4,24854.7,34794.1,0.9625311985649246,-0.055094791298501526,0.7624019066329704,0.1178160262743173,0.8398486112404492,0.07579899159079866,6635]
["P25440-1","Bromodomain-containing protein 2 [OS=Homo sapiens]",3,2,2,2,801,88,9.09,5.99,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","kinase activity;other molecular function","BRD2","ENSG00000204256; ENSG00000215077; ENSG00000234507; ENSG00000234704; ENSG00000235307; ENSGGOG00000043461","","RUNX3 regulates p14-ARF","",164.5,152.4,146.5,679.3,697.2,375.8,0.26445243394395934,-1.9189198412977853,0.014674958556563178,1.8334231165662993,0.12357058996534592,0.9080848798588184,868]
["P25786-1","Proteasome subunit alpha type-1 [OS=Homo sapiens]",64,17,151,17,263,29.5,6.61,439.06,"protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","PSMA1","ENSCANG00000029071; ENSCATG00000014932; ENSCJAG00000009850; ENSCPOG00000015226; ENSG00000129084; ENSGGOG00000001416; ENSHGLG00000008245; ENSMFAG00000036829; ENSMLEG00000030594; ENSMMUG00000016446; ENSMNEG00000005235; ENSOCUG00000000439; ENSPANG00000016448; ENSPPYG00000003466; ENSPTRG00000003385; ENSRBIG00000037598; ENSRROG00000037748; ENSSSCG00000013391; ENSSTOG00000006270; ENSTSYG00000003869","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration","ER-Phagosome pathway; MAPK6/MAPK4 signaling; Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Downstream TCR signaling; UCH proteinases; Regulation of expression of SLITs and ROBOs; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease",15165.3,15503.2,16238.4,16137.9,16086.5,14506.1,1.0037748365628443,5.4356850205485915E-3,0.9292587142062199,0.03186335757802018,0.9571521902668068,0.019019002517717213,7096]
["P26006","Integrin alpha-3 [OS=Homo sapiens]",1,1,1,1,1051,116.5,6.77,1.82,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","ITGA3","ENSG00000005884","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Hematopoietic cell lineage; Regulation of actin cytoskeleton; Human papillomavirus infection; Pathways in cancer; Small cell lung cancer; Hypertrophic cardiomyopathy; Arrhythmogenic right ventricular cardiomyopathy; Dilated cardiomyopathy","Integrin cell surface interactions; Laminin interactions; MET activates PTK2 signaling; Basigin interactions","Integrin-mediated cell adhesion; Arrhythmogenic right ventricular cardiomyopathy; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ebola virus pathway in host; Small cell lung cancer; Nephrotic syndrome; Genes controlling nephrogenesis; Malignant pleural mesothelioma",58.8,73,62.6,65.1,65.7,93.6,0.8663101604278075,-0.2070444570030119,0.3872209758225259,0.4120411249245029,0.5738438994904383,0.24120623096422397,4932]
["P26358-1","DNA (cytosine-5)-methyltransferase 1 [OS=Homo sapiens]",36,45,110,1,1616,183.1,7.75,300.92,"cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DNMT1","ENSG00000130816","Cysteine and methionine metabolism; Metabolic pathways; MicroRNAs in cancer","NoRC negatively regulates rRNA expression; PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; SUMOylation of DNA methylation proteins","Trans-sulfuration pathway; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration and one-carbon metabolism; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; MTHFR deficiency",378.3,400.6,346.7,622.5,699,270,0.7072573044297833,-0.49969292328675047,0.3078931304224936,0.511600000778147,0.5267768937869863,0.2783732829146741,4272]
["P26373-1","60S ribosomal protein L13 [OS=Homo sapiens]",39,10,37,10,211,24.2,11.65,99.04,"protein metabolism;other metabolic processes;developmental processes","cytosol;ER/Golgi;translational apparatus;nucleus","other molecular function","RPL13","ENSG00000167526","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",5768,5565.2,5426.4,5994.4,6414.3,5247.7,0.9492082191160144,-0.07520350212354084,0.44747321875328905,0.3492329520703349,0.609841834023455,0.21478278714943005,5363]
["P26885","Peptidyl-prolyl cis-trans isomerase FKBP2 [OS=Homo sapiens]",44,4,14,4,142,15.6,9.13,41.59,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","FKBP2","ENSG00000173486","","","Complement system",1474.1,1522.3,1457.9,1422,1491.2,2248,0.8630357281252421,-0.2125078092697351,0.424566648481452,0.3720541245114201,0.5948164910390901,0.22561699934982202,5217]
["P27540","Aryl hydrocarbon receptor nuclear translocator [OS=Homo sapiens]",4,3,4,3,789,86.6,6.54,8.99,"stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","ARNT","ENSG00000143437","HIF-1 signaling pathway; Cushing syndrome; Pathways in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Renal cell carcinoma","PPARA activates gene expression; Endogenous sterols; Xenobiotics; Aryl hydrocarbon receptor signalling; Regulation of gene expression by Hypoxia-inducible Factor","Angiogenesis; Aryl hydrocarbon receptor Netpath; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; Type 2 papillary renal cell carcinoma",321.4,339.6,365,386.6,382.1,407.9,0.8720040795512494,-0.19759321041888878,0.028294075982932418,1.548304484519473,0.16664093582534492,0.7782183041342297,1241]
["P27695","DNA-(apurinic or apyrimidinic site) lyase [OS=Homo sapiens]",61,17,74,17,318,35.5,8.12,255.72,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytoskeleton;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component","nucleic acid binding activity;other molecular function","APEX1","ENSG00000100823","Base excision repair","Displacement of DNA glycosylase by APEX1; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Abasic sugar-phosphate removal via the single-nucleotide replacement pathway","Thyroid stimulating hormone (TSH) signaling pathway; Spinal cord injury; Base excision repair; DNA repair pathways, full network",8686.8,8553.4,8986,8739.9,9806.9,6166.9,1.0612008723906172,0.08569776668857534,0.6671449733158654,0.1757797818709244,0.7694749266160108,0.11380552711219105,6337]
["P27986","Phosphatidylinositol 3-kinase regulatory subunit alpha [OS=Homo sapiens]",16,10,16,9,724,83.5,6.16,43.18,"cell adhesion;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","PIK3R1","ENSG00000145675","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; Platinum drug resistance; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Phosphatidylinositol signaling system; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Osteoclast differentiation; Focal adhesion; Signaling pathways regulating pluripotency of stem cells; Platelet activation; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; TNF signaling pathway; Leukocyte transendothelial migration; Neurotrophin signaling pathway; Cholinergic synapse; Inflammatory mediator regulation of TRP channels; Regulation of actin cytoskeleton; Insulin signaling pathway; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Prolactin signaling pathway; Thyroid hormone signaling pathway; Regulation of lipolysis in adipocytes; Relaxin signaling pathway; GnRH secretion; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Aldosterone-regulated sodium reabsorption; Carbohydrate digestion and absorption; Alzheimer disease; Spinocerebellar ataxia; Prion disease; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection; Chagas disease; Amoebiasis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Signaling by FGFR1 in disease; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; G alpha (q) signalling events; RAC1 GTPase cycle; VEGFA-VEGFR2 Pathway; RHOC GTPase cycle; CDC42 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; RAF/MAP kinase cascade; PI3K Cascade; PI-3K cascade:FGFR4; Signaling by FGFR4 in disease; Downstream TCR signaling; RND2 GTPase cycle; RHOF GTPase cycle; Extra-nuclear estrogen signaling; RHOV GTPase cycle; Signaling by ALK fusions and activated point mutants; RHOU GTPase cycle; Synthesis of PIPs at the plasma membrane; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Regulation of signaling by CBL; Nephrin family interactions; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; Costimulation by the CD28 family; CD28 dependent PI3K/Akt signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; RND3 GTPase cycle; RND1 GTPase cycle; Interleukin-4 and Interleukin-13 signaling; PI3K events in ERBB4 signaling; PI3K events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; GAB1 signalosome; Signaling by cytosolic FGFR1 fusion mutants; PI-3K cascade:FGFR1; PI-3K cascade:FGFR2; Signaling by FGFR2 in disease; PI-3K cascade:FGFR3; Signaling by FGFR3 point mutants in cancer; FLT3 Signaling; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FGFR3 fusions in cancer; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants; GP1b-IX-V activation signalling; MET activates PI3K/AKT signaling; Activated NTRK3 signals through PI3K; Activated NTRK2 signals through PI3K","IL-5 signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase (AMPK) signaling; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Apoptosis; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; IL-6 signaling pathway; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Ebola virus pathway in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Overview of interferons-mediated signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; IL-18 signaling pathway; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; Modulators of TCR signaling and T cell activation; Orexin receptor pathway; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; Interferon type I signaling pathways; Notch signaling pathway (Netpath); ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway",1611,1659.2,1731.5,1477,1613.2,1440.8,1.1038843522401236,0.14258903698108555,0.06771605743832262,1.1693083353035758,0.2569764609640187,0.5901066562081185,1926]
["P28072","Proteasome subunit beta type-6 [OS=Homo sapiens]",31,7,35,7,239,25.3,4.92,93.1,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","PSMB6","ENSG00000142507","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease",3236.7,3493.4,3494.4,3397.3,3005.1,2059.3,1.20832693194039,0.27301085141415354,0.2216171106432477,0.6543967115831933,0.4549998487897465,0.3419887476720956,3560]
["P28288","ATP-binding cassette sub-family D member 3 [OS=Homo sapiens]",22,11,28,11,659,75.4,9.36,86.64,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ABCD3","ENSG00000117528","ABC transporters; Peroxisome","RHOA GTPase cycle; RHOC GTPase cycle; Class I peroxisomal membrane protein import; ABC transporters in lipid homeostasis","Nuclear receptors in lipid metabolism and toxicity; Fragile X syndrome",2025,1912.1,1909.5,1780.8,1746.5,2376,0.990395202683245,-0.013923768503454403,0.9319265925303774,0.030618295494258842,0.9592242592317318,0.018079846259031085,7101]
["P28347","Transcriptional enhancer factor TEF-1 [OS=Homo sapiens]",10,2,2,2,426,47.9,8.15,5.03,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TEAD1","ENSG00000187079","Hippo signaling pathway; Hippo signaling pathway","YAP1- and WWTR1 (TAZ)-stimulated gene expression; EGR2 and SOX10-mediated initiation of Schwann cell myelination; RUNX3 regulates YAP1-mediated transcription","Mesodermal commitment pathway; Mesodermal commitment pathway; miR-509-3p alteration of YAP1/ECM axis; Transcription co-factors SKI and SKIL protein partners; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Overview of leukocyte-intrinsic Hippo pathway functions; Malignant pleural mesothelioma",62.8,105.4,94.2,75.2,89.3,51.8,1.213129912159038,0.27873405465610457,0.4120438445938246,0.3850565692774355,0.5890139761659033,0.2298744001199995,5113]
["P28702","Retinoic acid receptor RXR-beta [OS=Homo sapiens]",12,4,6,4,533,56.9,8.18,23.05,"signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RXRB","ENSG00000204231; ENSG00000206289; ENSG00000227322; ENSG00000228333; ENSG00000231321; ENSG00000235712","PPAR signaling pathway; Th17 cell differentiation; Thyroid hormone signaling pathway; Adipocytokine signaling pathway; Parathyroid hormone synthesis, secretion and action; Pathways in cancer; Transcriptional misregulation in cancer; Chemical carcinogenesis; Thyroid cancer; Small cell lung cancer; Non-small cell lung cancer; Gastric cancer; Lipid and atherosclerosis","NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; PPARA activates gene expression; Nuclear Receptor transcription pathway; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis; Signaling by Retinoic Acid; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose; NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake ; NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis","Vitamin D metabolism; Nuclear receptors; PPAR signaling pathway; Non-small cell lung cancer; Non-genomic actions of 1,25 dihydroxyvitamin D3; Small cell lung cancer; IL-18 signaling pathway; Vitamin A and carotenoid metabolism",507.2,547.2,508.5,627.3,661.4,618.3,0.8195595175668591,-0.2870793712116412,3.4833593928652175E-3,2.4580017152385523,0.062709048774512,1.2026697869317733,406]
["P29218-1","Inositol monophosphatase 1 [OS=Homo sapiens]",35,8,29,8,277,30.2,5.26,96.42,"other metabolic processes;signal transduction","cytosol;other cell component","other molecular function","IMPA1","ENSG00000133731","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of IP2, IP, and Ins in the cytosol","Integrated breast cancer pathway",2198.8,2258.1,2299.4,2174.2,2075.2,1677.9,1.1398613196565048,0.18885831069332762,0.14806870106706468,0.8295367334464431,0.37893352104312883,0.4214369746666068,2856]
["P29466-1","caspase-1 [OS=Homo sapiens]",45,15,58,15,404,45.1,5.91,200.9,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;other cell component","enzyme regulator activity;other molecular function","CASP1","ENSG00000137752","Necroptosis; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; Amyotrophic lateral sclerosis; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Legionellosis; Yersinia infection; Influenza A; Coronavirus disease; Lipid and atherosclerosis","The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; NOD1/2 Signaling Pathway; TP53 Regulates Transcription of Caspase Activators and Caspases; The AIM2 inflammasome; Pyroptosis; Interleukin-37 signaling; Interleukin-1 processing; The IPAF inflammasome","Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis modulation and signaling; Parkin-ubiquitin proteasomal system pathway; Amyotrophic lateral sclerosis (ALS); Apoptosis; Cytosolic DNA-sensing pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Malignant pleural mesothelioma; Prostaglandin signaling",5308.7,5426.4,5434,5615.7,5708.6,4189.2,1.042259967125407,0.05971516869572922,0.6807182041226072,0.16703263510969169,0.7805725374854308,0.10758673236343262,6374]
["P29597","Non-receptor tyrosine-protein kinase TYK2 [OS=Homo sapiens]",4,6,7,5,1187,133.6,7.15,21.06,"protein metabolism;other metabolic processes;stress response;signal transduction","other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","TYK2","ENSG00000105397","Necroptosis; Osteoclast differentiation; NOD-like receptor signaling pathway; JAK-STAT signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease","Potential therapeutics for SARS; Interleukin-4 and Interleukin-13 signaling; Interleukin-10 signaling; Interleukin-6 signaling; Regulation of IFNA signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; IL-6-type cytokine receptor ligand interactions; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-12 signaling; Interleukin-23 signaling; Interleukin-27 signaling; Other interleukin signaling","Type III interferon signaling; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; IL-6 signaling pathway; IL-4 signaling pathway; Immune response to tuberculosis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Overview of interferons-mediated signaling pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Interferon type I signaling pathways",734.5,683.2,687.8,705.7,732.4,1347.3,0.7559057944998924,-0.4037216465209409,0.34163019287189683,0.4664437538548048,0.5474621968210248,0.26164586421177005,4561]
["P30041","Peroxiredoxin-6 [OS=Homo sapiens]",73,18,185,18,224,25,6.38,666,"other metabolic processes;stress response;other biological processes","non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PRDX6","ENSG00000117592","Glutathione metabolism; Metabolic pathways","Neutrophil degranulation; Detoxification of Reactive Oxygen Species","Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling pathway",22693.3,22028.9,23585.9,23336.3,23487.2,18963.7,1.038319004304789,0.054249753159520984,0.6166046733317436,0.20999318801934347,0.732092845578576,0.13543383729481162,6156]
["P30085-1","UMP-CMP kinase [OS=Homo sapiens]",47,10,43,10,196,22.2,5.57,139.27,"other metabolic processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","CMPK1","ENSG00000162368","Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors","Interconversion of nucleotide di- and triphosphates","Pyrimidine metabolism",5898.5,5774.7,6023.7,6616.8,6732.5,5424.5,0.942638144648393,-0.08522403247997194,0.44507212964360043,0.35156960032758466,0.6082707919904778,0.21590303703355845,5348]
["P30154","Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [OS=Homo sapiens]",26,13,56,6,601,66.2,4.94,165.5,"protein metabolism;other metabolic processes;other biological processes","other membranes;other cell component","enzyme regulator activity","PPP2R1B","ENSG00000137713","mRNA surveillance pathway; Sphingolipid signaling pathway; Oocyte meiosis; PI3K-Akt signaling pathway; AMPK signaling pathway; Adrenergic signaling in cardiomyocytes; TGF-beta signaling pathway; Hippo signaling pathway; Tight junction; Dopaminergic synapse; Long-term depression; Chagas disease; Hepatitis C; Human papillomavirus infection","Regulation of TP53 Degradation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; DARPP-32 events; Cyclin A/B1/B2 associated events during G2/M transition; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Cyclin D associated events in G1; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; S33 mutants of beta-catenin aren't phosphorylated; S37 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; T41 mutants of beta-catenin aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; MASTL Facilitates Mitotic Progression; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Netrin-UNC5B signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome",1140.6,1210.2,1226.7,1388.8,1393.9,1137.8,0.9125111592909069,-0.132085892878349,0.26621443654275456,{"$f":"-LOG10(AA1603)","v":0.5747683968671554},0.49334718983037346,{"$f":"-LOG10(AC1603)","v":0.3068473412523561},3944]
["P30414","NK-tumor recognition protein [OS=Homo sapiens]",8,12,20,12,1462,165.6,9.99,53.52,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","NKTR","ENSG00000114857","","","",2150.7,2094.9,2113.9,2093.4,2149.7,2438.8,0.9517502506772025,-0.07134505011484009,0.37697154422872586,0.42369143136147747,0.5689211267329667,0.24494793852404384,4843]
["P30479","HLA class I histocompatibility antigen, B-41 alpha chain [OS=Homo sapiens]",40,12,106,2,362,40.5,6.54,299.71,"other biological processes","plasma membrane;other membranes","","HLA-B","","","","",3328.7,3282.8,3406.4,2762.2,2901.7,4118.5,1.024073846908734,0.034319753157860275,0.8647202137288001,0.06312438882330183,0.9117484192359782,0.040124980981208244,6932]
["P30622-2","Isoform 3 of CAP-Gly domain-containing linker protein 1 [OS=Homo sapiens]",28,35,54,1,1392,156.7,5.36,147.85,"","","","CLIP1","","","","",318.3,317.4,314.6,371.3,389,479.7,0.7663709677419356,-0.3838851860680702,0.045257674745782094,1.3443077630418598,0.2105590991196189,0.6766259861978603,1571]
["P31146","Coronin-1A [OS=Homo sapiens]",62,30,362,27,461,51,6.68,1038.25,"cell adhesion;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","CORO1A","ENSG00000102879","Phagosome; Tuberculosis","Prevention of phagosomal-lysosomal fusion","16p11.2 proximal deletion syndrome",42399.4,41595.6,42097.1,40321.8,39726.6,42214.9,1.031316020424772,0.0444864774585145,0.17972714213773702,0.7453863314023115,0.41334980550179984,0.3836822623896992,3178]
["P31153","S-adenosylmethionine synthase isoform type-2 [OS=Homo sapiens]",59,18,128,14,395,43.6,6.48,410.75,"cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;other cell component","other molecular function","MAT2A","ENSG00000168906","Cysteine and methionine metabolism; Metabolic pathways; Biosynthesis of amino acids; Biosynthesis of cofactors","Methylation","Trans-sulfuration and one-carbon metabolism; Methionine de novo and salvage pathway; One-carbon metabolism and related pathways; Methylation pathways",13316.9,13906.9,13969.7,14292,13405.7,13677.3,0.9956132930513595,-0.006342602122404628,0.8653098406551736,0.06282835728353575,0.911975432638596,0.04001686080886647,6935]
["P31641","Sodium- and chloride-dependent taurine transporter [OS=Homo sapiens]",1,1,1,1,620,69.8,7.39,0,"transport;other biological processes","plasma membrane;other membranes;other cell component","transporter activity","SLC6A6","ENSG00000131389","","Na+/Cl- dependent neurotransmitter transporters; Amino acid transport across the plasma membrane","Nuclear receptors meta-pathway; NRF2 pathway",74.6,63.5,64.4,74.7,69.1,114.8,0.7830626450116009,-0.3528003671509049,0.2757131543864127,0.55954251303406,0.5022899913784373,0.29904547549846755,4012]
["P31943","Heterogeneous nuclear ribonucleoprotein H [OS=Homo sapiens]",56,20,433,8,449,49.2,6.3,1435.7,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","HNRNPH1","ENSG00000169045; ENSG00000284254","","mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA","MECP2 and associated Rett syndrome; mRNA processing; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells",31710.3,30740.4,30152.4,32126.9,33206.3,36018.8,0.9136780724603363,-0.130242162729752,0.07929734663151347,1.1007413443667748,0.2790487754115224,0.5543198790179008,2077]
["P31947-1","14-3-3 protein sigma [OS=Homo sapiens]",62,15,140,11,248,27.8,4.74,392.51,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;nucleus","enzyme regulator activity;other molecular function","SFN","ENSG00000175793; ENSGGOG00000011493; ENSNLEG00000018582; ENSPPAG00000013397; ENSPTRG00000030723","Cell cycle; p53 signaling pathway; Aldosterone-regulated sodium reabsorption","TP53 Regulates Metabolic Genes; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; Activation of BAD and translocation to mitochondria ; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest","miRNA regulation of DNA damage response; Cell cycle; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells; DNA damage response; Calcium regulation in cardiac cells",1956.8,2073.6,2061.6,2237,2133,2660.6,0.8664978806929707,-0.2067318740852761,0.13178946350357107,0.880119309963366,0.3572882747580122,0.44698123594267525,2696]
["P32246","C-C chemokine receptor type 1 [OS=Homo sapiens]",3,1,1,1,355,41.1,8.16,1.86,"cell adhesion;cell-cell signaling;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","CCR1","ENSG00000163823","Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor; Chemokine signaling pathway; Human cytomegalovirus infection; Kaposi sarcoma-associated herpesvirus infection","G alpha (i) signalling events; Chemokine receptors bind chemokines; Interleukin-10 signaling","Peptide GPCRs; Chemokine signaling pathway; Selective expression of chemokine receptors during T-cell polarization; GPCRs, class A rhodopsin-like; CCL18 signaling pathway",103.4,124,115.7,258.2,272.4,240.4,0.44500648508430624,-1.1681017342447417,2.0574584442182092E-4,3.6866689277458162,0.016169853514828917,1.7912939144157785,93]
["P32455","Guanylate-binding protein 1 [OS=Homo sapiens]",35,18,53,16,592,67.9,6.32,161.45,"stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","GBP1","ENSG00000117228","NOD-like receptor signaling pathway","Interferon gamma signaling","Type II interferon signaling (IFNG)",6067.6,5749.3,5690.2,5838.2,5614.4,7399.3,0.9286650151974073,-0.10676980836199298,0.4781067837398853,0.3204750941626132,0.6314568995942937,0.1996562870835734,5534]
["P33121","Long-chain-fatty-acid--CoA ligase 1 [OS=Homo sapiens]",8,7,12,6,698,77.9,7.15,31.55,"other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle","other molecular function","ACSL1","ENSG00000151726","Fatty acid biosynthesis; Fatty acid degradation; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; Peroxisome; Ferroptosis; Thermogenesis; Adipocytokine signaling pathway","PPARA activates gene expression; Synthesis of very long-chain fatty acyl-CoAs; alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism","Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters",927.2,952.7,975.9,954.5,881.7,1926.4,0.7589964386328603,-0.3978349786521089,0.420520926157597,0.37621238776465504,0.5933566504412889,0.22668418562591508,5180]
["P33981","Dual specificity protein kinase TTK [OS=Homo sapiens]",6,5,6,5,857,97,8.16,15.62,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","TTK","ENSG00000112742","Cell cycle","","Cell cycle; Retinoblastoma gene in cancer",570.3,595.1,589.1,596.3,551.9,437.3,1.1065909807631664,0.14612207029832774,0.3052457317660417,0.5153504000560214,0.5248273473248645,0.2799835431391713,4251]
["P33993-1","DNA replication licensing factor MCM7 [OS=Homo sapiens]",68,42,230,42,719,81.3,6.46,689.22,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","MCM7","ENSG00000166508","DNA replication; Cell cycle","Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Assembly of the pre-replicative complex; Unwinding of DNA","miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication",24280.2,25246.2,25034.2,24061.8,23234.6,20324.3,1.1026298160178762,0.14094851873061323,0.11934673380664888,0.9231894619455311,0.34383337697784655,0.46365196728328884,2537]
["P34932","Heat shock 70 kDa protein 4 [OS=Homo sapiens]",77,56,447,51,840,94.3,5.19,1386.98,"cell organization and biogenesis;stress response;transport","non-structural extracellular;cytosol;mitochondrion;nucleus","other molecular function","HSPA4","ENSG00000170606","Tight junction; Antigen processing and presentation; Lipid and atherosclerosis","Regulation of HSF1-mediated heat shock response","Parkin-ubiquitin proteasomal system pathway",52366.2,53112,53478,50395.3,50025.7,42113.3,1.1152136713759426,0.15732015238907623,0.11456176466887583,0.9409603052662078,0.3366835295395309,0.47277812865217084,2487]
["P35236","Tyrosine-protein phosphatase non-receptor type 7 [OS=Homo sapiens]",31,8,27,8,360,40.5,6.79,80.38,"protein metabolism;other metabolic processes;signal transduction","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","PTPN7","ENSG00000143851","MAPK signaling pathway","Interleukin-37 signaling; Negative regulation of MAPK pathway","MAPK signaling pathway; IL-18 signaling pathway",3088.8,2956.1,3010.9,3030.4,2828.2,2957.7,1.0271655910075657,0.03866877958004764,0.32112167819332316,0.4933303752122344,0.5359850070598308,0.270847358520387,4379]
["P35241-1","radixin [OS=Homo sapiens]",55,38,230,19,583,68.5,6.37,622.21,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","RDX","ENSG00000137710; ENSPPAG00000040677; ENSRBIG00000033138; ENSRROG00000036137","Tight junction; Regulation of actin cytoskeleton; Proteoglycans in cancer; MicroRNAs in cancer","Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea","Regulation of actin cytoskeleton",8739.7,8711.2,9046.5,9634.7,9424,10184.9,0.9060922731811405,-0.14227011825572813,0.021811310726016064,1.661318235202053,0.14733721820374437,0.8316875340886306,1082]
["P35556","Fibrillin-2 [OS=Homo sapiens]",0,1,1,1,2912,314.6,4.86,0,"developmental processes;other biological processes","non-structural extracellular;extracellular matrix","extracellular structural activity;other molecular function","FBN2","ENSG00000138829","","Degradation of the extracellular matrix; Molecules associated with elastic fibres","Hypothesized pathways in pathogenesis of cardiovascular disease",70.8,29.8,23.2,142.3,61.3,142.3,0.35790690951141946,-1.4823436991586636,0.07426818226056336,1.129197205461912,0.2703317450908654,0.5681029520509207,2008]
["P35568","Insulin receptor substrate 1 [OS=Homo sapiens]",3,3,5,3,1242,131.5,8.54,11.72,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","IRS1","ENSG00000169047","cGMP-PKG signaling pathway; FoxO signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Neurotrophin signaling pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Regulation of lipolysis in adipocytes; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; Growth hormone synthesis, secretion and action; Aldosterone-regulated sodium reabsorption; Alzheimer disease; MicroRNAs in cancer; Diabetic cardiomyopathy","RAF/MAP kinase cascade; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by ALK fusions and activated point mutants; PI3K Cascade; Interleukin-7 signaling; PI3K/AKT activation; Signaling by ALK; Growth hormone receptor signaling; Signaling by Leptin; SOS-mediated signalling; IRS activation; Signal attenuation; Activated NTRK3 signals through PI3K","Type II diabetes mellitus; Integrated breast cancer pathway; Leptin signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; AGE/RAGE pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Transcription factor regulation in adipogenesis; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; PI3K-Akt signaling pathway; Nonalcoholic fatty liver disease; Gastrin signaling pathway; Insulin signaling; FOXA2 pathway; Neuroinflammation and glutamatergic signaling; Congenital generalized lipodystrophy (CGL); Alzheimer's disease; EPO receptor signaling; Interferon type I signaling pathways; DNA damage response (only ATM dependent)",330.5,332.5,340.2,538.4,529.7,623.2,0.5931531957665702,-0.7535233320568484,1.5661385306797737E-3,2.805169825644041,0.043033483160670925,1.366193500391135,266]
["P35612-1","Beta-adducin [OS=Homo sapiens]",17,9,14,9,726,80.8,5.92,31.34,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ADD2","ENSG00000075340","","Miscellaneous transport and binding events","",880.9,894,914.3,951.9,917.1,1201.3,0.8758753216298081,-0.1912025739969536,0.23105052691667963,0.6362930367243913,0.4614066396814239,0.335916160234829,3660]
["P35813","Protein phosphatase 1A [OS=Homo sapiens]",39,13,32,12,382,42.4,5.36,89.7,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus","other molecular function","PPM1A","ENSG00000100614","MAPK signaling pathway","Energy dependent regulation of mTOR by LKB1-AMPK; Downregulation of SMAD2/3:SMAD4 transcriptional activity","TGF-beta signaling pathway; MAPK signaling pathway",3305.7,3403.4,3405.9,3348.5,3301.5,4933.9,0.8731946926337417,-0.19562473337937608,0.41384297387524566,0.3831644137479963,0.5902006431325211,0.22900032159181524,5125]
["P35998","26S proteasome regulatory subunit 7 [OS=Homo sapiens]",67,25,125,25,433,48.6,5.95,394.41,"protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","PSMC2","ENSG00000161057","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection","Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of expression of SLITs and ROBOs; Downstream TCR signaling; Interleukin-1 signaling; Neutrophil degranulation; AUF1 (hnRNP D0) binds and destabilizes mRNA; MAPK6/MAPK4 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Orc1 removal from chromatin; SCF(Skp2)-mediated degradation of p27/p21; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease",11686.3,11795.9,12165.1,12173,11663.1,9645.7,1.064676928958419,0.09041571805748115,0.40990233517798236,0.38731960753852823,0.587446307414877,0.23103182175249165,5100]
["P36551","Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial [OS=Homo sapiens]",43,18,69,18,454,50.1,8.25,212.4,"other metabolic processes","cytosol;mitochondrion;other cell component","other molecular function","CPOX","ENSG00000080819","Porphyrin and chlorophyll metabolism; Metabolic pathways; Biosynthesis of cofactors","Heme biosynthesis","Heme biosynthesis",7409.1,7214.8,7290.6,7153.6,6752.8,8091.3,0.9962177864049423,-5.4669258672907575E-3,0.948133228018911,0.023130632990929444,0.9689465553118316,0.013700176894817784,7152]
["P36969","Phospholipid hydroperoxide glutathione peroxidase, mitochondrial [OS=Homo sapiens]",38,8,39,8,197,22.2,8.37,102.9,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","GPX4","ENSG00000167468","Glutathione metabolism; Metabolic pathways; Ferroptosis","Synthesis of 15-eicosatetraenoic acid derivatives; Synthesis of 12-eicosatetraenoic acid derivatives; Synthesis of 5-eicosatetraenoic acids","Glutathione metabolism; Selenium micronutrient network; Folate metabolism; One-carbon metabolism and related pathways; Ferroptosis; Metapathway biotransformation Phase I and II",3275,3495.6,3675.1,3059.1,2700.2,3102.3,1.1787600433330325,0.2372700630785546,0.03737951587431261,1.4273663277425301,0.18946385681369685,0.7224736262419674,1442]
["P37235","Hippocalcin-like protein 1 [OS=Homo sapiens]",52,10,18,10,193,22.3,5.35,42.62,"","other membranes","other molecular function","HPCAL1","ENSG00000115756","","","",2243.3,1999.9,2113.3,2692.4,2662.7,3285.2,0.7356804740576138,-0.4428487940748353,0.023847715809492395,1.6225532123823638,0.15236272277236007,0.8171212749553963,1144]
["P38432","coilin [OS=Homo sapiens]",16,10,16,10,576,62.6,9.07,42.12,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","COIL","ENSG00000121058","","","Genotoxicity pathway",1441.7,1481.6,1475,1873.8,2051.8,2588.2,0.67522797752464,-0.5665534127026937,0.030531811076137307,1.515247433597034,0.17325854592817358,0.7613053347368545,1288]
["P38606","V-type proton ATPase catalytic subunit A [OS=Homo sapiens]",66,30,212,30,617,68.3,5.52,604.83,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ATP6V1A","ENSG00000114573","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis","Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Proximal tubule transport",20458.2,20785.7,20714.9,19573.5,18777,16701.5,1.1254595655017074,0.1705142258742078,0.055721519518884315,1.2539770489302606,0.23325806767670415,0.6321633264158385,1746]
["P39210","Protein Mpv17 [OS=Homo sapiens]",16,2,3,2,176,19.7,9.47,5.65,"cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","transporter activity","MPV17","ENSG00000115204","Peroxisome","Peroxisomal protein import","",282.9,259.6,315.3,280,369.3,340.7,0.8664646464646465,-0.206787209218778,0.22682410760360025,0.6443107890965312,0.457718774841169,0.3394012731905979,3622]
["P40306","Proteasome subunit beta type-10 [OS=Homo sapiens]",27,6,23,6,273,28.9,7.81,77.74,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PSMB10","ENSG00000205220","Proteasome","Regulation of PTEN stability and activity; FCERI mediated NF-kB activation; Downstream TCR signaling; Regulation of expression of SLITs and ROBOs; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; MAPK6/MAPK4 signaling; Degradation of beta-catenin by the destruction complex; ER-Phagosome pathway; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; CDT1 association with the CDC6:ORC:origin complex; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation",2677.2,2822.9,2991.5,2768.7,2808.6,3426.3,0.9431338575680841,-0.0844655499204949,0.5017601357719037,0.2995038458153706,0.6489762577166597,0.18777119122929592,5651]
["P40616","ADP-ribosylation factor-like protein 1 [OS=Homo sapiens]",64,9,33,9,181,20.4,5.72,97.08,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","ARL1","ENSG00000120805","","Retrograde transport at the Trans-Golgi-Network","",2170.3,2324.7,2251.5,2187.3,2186.1,1673.5,1.115695645702757,0.15794352329584144,0.2575714361179708,0.5891023005675337,0.4857042380253479,0.31362810706228844,3876]
["P40937-1","Replication factor C subunit 5 [OS=Homo sapiens]",45,13,39,13,340,38.5,7.2,117.6,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RFC5","ENSG00000111445","DNA replication; Nucleotide excision repair; Mismatch repair","Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER","Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair",4267.2,4605.9,4543,4415,3909.8,4728.2,1.0278173599938711,0.03958392480343694,0.6659107285748405,0.17658398807589226,0.7686578514140097,0.11426693238223758,6332]
["P41226","ubiquitin-like modifier-activating enzyme 7 [OS=Homo sapiens]",8,7,9,7,1012,111.6,6.04,25.58,"protein metabolism;other metabolic processes;stress response","cytosol;nucleus;other cell component","other molecular function","UBA7","ENSG00000182179","Ubiquitin mediated proteolysis; Parkinson disease; Pathways of neurodegeneration","Termination of translesion DNA synthesis; Antigen processing: Ubiquitination & Proteasome degradation; ISG15 antiviral mechanism; Negative regulators of DDX58/IFIH1 signaling","Proteasome degradation; Parkinson's disease pathway",1053.6,1019.4,1048.4,1052.4,967.9,1962.7,0.7836806427316093,-0.3516622326535029,0.4183631285998238,0.37844659792484275,0.5930597569697658,0.22690154472223517,5156]
["P41227-1","N-alpha-acetyltransferase 10 [OS=Homo sapiens]",47,12,58,12,235,26.4,5.64,151.74,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","translation activity;other molecular function","NAA10","ENSCATG00000038709; ENSCSAG00000006823; ENSG00000102030; ENSGGOG00000009788; ENSMFAG00000044161; ENSMMUG00000000322; ENSMNEG00000034261; ENSPPYG00000020861; ENSPTRG00000022419; ENSRROG00000041881","","","",4841.3,4820.2,4737.9,5753.6,5395,7997,{"$f":"AVERAGE(S1794:U1794)/AVERAGE(V1794:X1794)","v":0.7520996991475849},{"$f":"LOG(Y1794,2)","v":-0.41100417509630066},{"$f":"TTEST(V1794:X1794,S1794:U1794,2,2)","v":0.12413501892327873},0.9061056852236609,{"$f":"AA1794*7309/AE1794","v":0.34990468696885624},0.45605024010903944,2593]
["P41567","eukaryotic translation initiation factor 1 [OS=Homo sapiens]",39,4,6,4,113,12.7,7.44,21.11,"protein metabolism;other metabolic processes;other biological processes","translational apparatus;nucleus;other cell component","translation activity;nucleic acid binding activity","EIF1","ENSG00000173812","","","Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell",239,271.2,242.7,293.4,302.3,274.4,0.8653028387541661,-0.20872295924081918,0.04050371064836427,1.392505188136216,0.19775659394047726,0.7038690265952955,1497]
["P42167-2","Isoform Gamma of Lamina-associated polypeptide 2, isoforms beta/gamma [OS=Homo sapiens]",54,18,162,2,345,38.7,9.16,512.19,"","","","TMPO","","","","",534.6,469.3,477.4,585.6,606.7,486.7,0.8822513400833829,-0.1807383785191636,0.19436564364051295,0.711380499162703,0.4290602504888279,0.36748171803079843,3311]
["P42285","Superkiller viralicidic activity 2-like 2 [OS=Homo sapiens]",29,28,77,28,1042,117.7,6.52,226.12,"RNA metabolism OR transcription;other metabolic processes;stress response","nucleus","other molecular function","MTREX","ENSG00000039123","RNA degradation","Major pathway of rRNA processing in the nucleolus and cytosol; mRNA Splicing - Major Pathway","",6994.4,7140.9,7273.3,9534.3,9726.6,7600.9,0.7969905218563162,-0.32736552770072186,0.05643478724344462,1.248453107886483,0.23463131966003226,0.6296140167402631,1758]
["P42574","Caspase-3 [OS=Homo sapiens]",50,10,57,9,277,31.6,6.54,162.65,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","CASP3","ENSG00000164305","Platinum drug resistance; MAPK signaling pathway; p53 signaling pathway; Apoptosis; Apoptosis; Natural killer cell mediated cytotoxicity; IL-17 signaling pathway; TNF signaling pathway; Serotonergic synapse; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Alcoholic liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Salmonella infection; Pertussis; Legionellosis; Toxoplasmosis; Amoebiasis; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Colorectal cancer; Small cell lung cancer; Viral myocarditis; Lipid and atherosclerosis","Caspase-mediated cleavage of cytoskeletal proteins; Degradation of the extracellular matrix; Other interleukin signaling; Apoptosis induced DNA fragmentation; Signaling by Hippo; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Caspase activation via Dependence Receptors in the absence of ligand; Pyroptosis; NADE modulates death signalling; Apoptotic cleavage of cell adhesion  proteins; Stimulation of the cell death response by PAK-2p34","miRNA regulation of DNA damage response; Integrated breast cancer pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; AGE/RAGE pathway; Allograft Rejection; Corticotropin-releasing hormone signaling pathway; Parkinson's disease pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Copper homeostasis; Hepatitis C and hepatocellular carcinoma; MAPK signaling pathway; Apoptosis modulation by HSP70; ERK pathway in Huntington's disease; Oxidative damage response; miRNA regulation of p53 pathway in prostate cancer; Prion disease pathway; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; MTHFR deficiency; Acute viral myocarditis; Nonalcoholic fatty liver disease; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; Peroxiredoxin 2 induced ovarian failure; Complement system in neuronal development and plasticity; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; Sudden infant death syndrome (SIDS) susceptibility pathways; DNA damage response",6532.7,6641.1,6680.1,7027.1,6930.9,6633.7,0.9641700296721495,-0.05264050928861112,0.12345346448303524,0.9084967179252225,0.3485211942473946,0.4577708064761215,2589]
["P42680","Tyrosine-protein kinase Tec [OS=Homo sapiens]",8,5,9,5,631,73.5,8.44,26.54,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton","kinase activity;other molecular function","TEC","ENSG00000135605","Osteoclast differentiation; T cell receptor signaling pathway","FCERI mediated Ca+2 mobilization; Interleukin-3, Interleukin-5 and GM-CSF signaling; Signaling by SCF-KIT","Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; Kit receptor signaling pathway",919.7,975.8,1019.7,893.9,946.5,1255.9,0.9415108355133545,-0.08695039648819008,0.6318942265112157,0.19935561267806776,0.743482759428602,0.12872909785061573,6212]
["P42766","60S ribosomal protein L35 [OS=Homo sapiens]",28,4,12,4,123,14.5,11.05,22.64,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;translational apparatus;nucleus","nucleic acid binding activity;other molecular function","RPL35","ENSG00000136942","Ribosome; Coronavirus disease","Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",2469.5,2491.2,2318.2,2417.4,2643.8,2010.2,1.0293435529032438,0.04172457537865837,0.7384205285901385,0.13169623813397338,0.8217289347541599,0.08527142036138481,6568]
["P43243","Matrin-3 [OS=Homo sapiens]",46,44,247,44,847,94.6,6.25,724.57,"stress response;developmental processes;other biological processes","other membranes;nucleus","nucleic acid binding activity;other molecular function","MATR3","ENSG00000015479","Amyotrophic lateral sclerosis","","",31982.3,31248.5,30813.1,34868.3,35524.9,29746.6,0.9391261017098094,-0.09060920527592528,0.33558576247312594,0.47419647278529525,0.5440985665297421,0.26432241827539127,4508]
["P43246-1","DNA mismatch repair protein MSH2 [OS=Homo sapiens]",46,34,131,34,934,104.7,5.77,390.5,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MSH2","ENSG00000095002","Platinum drug resistance; Mismatch repair; Pathways in cancer; Colorectal cancer","TP53 Regulates Transcription of DNA Repair Genes; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MSH3; Defective Mismatch Repair Associated With MSH2; Defective Mismatch Repair Associated With MSH6","RAC1/PAK1/p38/MMP2 pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ciliary landscape; DNA repair pathways, full network; p53 transcriptional gene network; DNA mismatch repair",15228.8,15627.2,15529.7,15945.3,15454.3,16052.4,0.9775288712804517,-0.03278878189138887,0.18105590274538355,0.7421873118413916,0.41406057358135434,0.38293612059937243,3196]
["P43490","nicotinamide phosphoribosyltransferase [OS=Homo sapiens]",64,26,133,26,491,55.5,7.15,417.93,"cell-cell signaling;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","NAMPT","ENSG00000105835","Nicotinate and nicotinamide metabolism; Metabolic pathways; NOD-like receptor signaling pathway","BMAL1:CLOCK,NPAS2 activates circadian gene expression; Nicotinamide salvaging","Adipogenesis; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; Caloric restriction and aging; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence",15461.6,15710.4,15906.4,15764.1,14495.6,14702.5,1.047066202276579,0.06635266163518094,0.1631849835889267,0.7873198078647359,0.39494008114286927,0.40346878893791355,3020]
["P45880","Voltage-dependent anion-selective channel protein 2 [OS=Homo sapiens]",65,14,219,13,294,31.5,7.56,684.41,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","transporter activity;other molecular function","VDAC2","ENSG00000165637","Calcium signaling pathway; cGMP-PKG signaling pathway; Ferroptosis; Necroptosis; Cellular senescence; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Cholesterol metabolism; Alzheimer disease; Parkinson disease; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Human T-cell leukemia virus 1 infection; Chemical carcinogenesis; Diabetic cardiomyopathy","Ub-specific processing proteases; Mitochondrial calcium ion transport","Alzheimer's disease and miRNA effects; Ferroptosis; Alzheimer's disease",19146.4,20452.9,20551.7,16009.5,15971.1,11325.8,1.388963294108954,0.47400847397251,0.02565174999737496,1.5908830013795296,0.15835189250913306,0.8003767418824577,1184]
["P46013","Proliferation marker protein Ki-67 [OS=Homo sapiens]",54,140,476,13,3256,358.5,9.45,1457.52,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MKI67","ENSG00000148773","","","Primary focal segmental glomerulosclerosis (FSGS)",56313.1,53154.6,51172,58365.7,60126.3,61058.2,0.8946784798903037,-0.16055877989098646,0.02039240630994823,1.6905315243213253,0.14331547857635732,0.8437069017361326,1040]
["P46108-1","Adapter molecule crk [OS=Homo sapiens]",21,4,6,4,304,33.8,5.55,20.67,"cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","Crk; CRK","ENSANAG00000030093; ENSBTAG00000005665; ENSCANG00000032179; ENSCATG00000041862; ENSCCAG00000032085; ENSG00000167193; ENSGGOG00000006758; ENSLAFG00000010559; ENSMFAG00000000502; ENSMMUG00000040390; ENSMNEG00000039514; ENSPPAG00000029995; ENSPTRG00000045379; ENSRBIG00000006454; ENSRROG00000035466","MAPK signaling pathway; ErbB signaling pathway; Rap1 signaling pathway; Chemokine signaling pathway; Focal adhesion; Fc gamma R-mediated phagocytosis; Neurotrophin signaling pathway; Regulation of actin cytoskeleton; Insulin signaling pathway; Growth hormone synthesis, secretion and action; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection; Human cytomegalovirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; MicroRNAs in cancer; Renal cell carcinoma; Chronic myeloid leukemia","Regulation of signaling by CBL; ARMS-mediated activation; FCGR3A-mediated phagocytosis; Regulation of signaling by CBL; Regulation of actin dynamics for phagocytic cup formation; Downstream signal transduction; VEGFA-VEGFR2 Pathway; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; ARMS-mediated activation; p130Cas linkage to MAPK signaling for integrins; MET activates RAP1 and RAC1; MET receptor recycling","Kit receptor signaling pathway; TCR signaling pathway; B cell receptor signaling pathway; ErbB signaling pathway; Hepatocyte growth factor receptor signaling; Actin cytoskeleton regulation; Integrin-mediated cell adhesion; Integrin-mediated cell adhesion; B cell receptor signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; Focal adhesion; Interferon type I signaling pathways; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Rett syndrome causing genes; EGF/EGFR signaling pathway; Gastrin signaling pathway; Insulin signaling; Regulation of actin cytoskeleton; Interferon type I signaling pathways; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; EGFR1 signaling pathway; MAPK signaling pathway; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; Integrin-mediated cell adhesion; Insulin signaling; EGF/EGFR signaling pathway; MAPK signaling pathway",475.1,429.7,489.7,492.2,510.6,363.9,1.0203409672934807,0.029051338101846926,0.8607519393483046,0.06512199011928844,0.9086129296211379,0.041621087438671704,6924]
["P46736","Lys-63-specific deubiquitinase BRCC36 [OS=Homo sapiens]",27,8,28,1,316,36,5.92,93.21,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","BRCC3","ENSG00000185515","Homologous recombination; NOD-like receptor signaling pathway","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs","",1965.7,1995.4,2066.6,1942.2,1926.3,1714.7,1.079613841524574,0.11051537855583368,0.13471866367720772,0.8705722337459482,0.36081301312448194,0.44271780753187173,2729]
["P46777","60S ribosomal protein L5 [OS=Homo sapiens]",64,20,365,20,297,34.3,9.72,1037.11,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;ER/Golgi;translational apparatus;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","RPL5","ENSG00000122406","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; SRP-dependent cotranslational protein targeting to membrane; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","VEGFA-VEGFR2 signaling pathway; Cytoplasmic ribosomal proteins",46313.6,44159.6,43281.5,46480.4,47979.2,46094.6,0.9516236441173583,-0.07153697736234534,0.10121078129288194,0.9947732226087376,0.31492107299688127,0.5017982775023705,2349]
["P46940","Ras GTPase-activating-like protein IQGAP1 [OS=Homo sapiens]",63,84,618,82,1657,189.1,6.48,2180.23,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","IQGAP1","ENSG00000140575","Adherens junction; Regulation of actin cytoskeleton; Proteoglycans in cancer","Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; RHOV GTPase cycle; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHO GTPases activate IQGAPs; RAC2 GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants","VEGFA-VEGFR2 signaling pathway; Ebola virus pathway in host; Ciliary landscape; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway",63781.9,63971.3,64768.3,56989,56244.8,43318.6,1.2297575763769832,0.29837394334571454,0.05435416715196292,1.2647671543978074,0.23110797423717103,0.6361850692008869,1719]
["P46976-2","Isoform GN-1 of Glycogenin-1 [OS=Homo sapiens]",39,10,56,10,333,37.5,5.4,196.35,"","","","GYG1","","","","",5389.9,5430.9,5382.4,4948.4,5270.3,4639,1.0905591040335987,0.1250679605201601,0.07025609296270212,1.1533160055818383,0.26292974063716834,0.5801602869857199,1953]
["P47985","cytochrome b-c1 complex subunit Rieske, mitochondrial [OS=Homo sapiens]",37,10,82,10,274,29.6,8.32,229.58,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity;other molecular function","UQCRFS1","ENSG00000169021","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly",7490.1,7688,7888.6,7146.1,6960.7,5919.7,1.1518088532694182,0.2039013163277668,0.06383148911977031,1.1949650238303313,0.2493556140974886,0.6031808494463683,1871]
["P48163","NADP-dependent malic enzyme [OS=Homo sapiens]",31,13,54,13,572,64.1,6.13,156.68,"other metabolic processes;other biological processes","cytosol;mitochondrion","other molecular function","ME1","ENSG00000065833","Pyruvate metabolism; Metabolic pathways; Carbon metabolism; PPAR signaling pathway","PPARA activates gene expression; Pyruvate metabolism","Nuclear receptors meta-pathway; NRF2 pathway; PPAR signaling pathway; Clear cell renal cell carcinoma pathways; TCA cycle in senescence",5199,5087.8,5129.2,5523.8,5140.7,4519.9,1.0152524959827192,0.021838574110270598,0.8060262527371719,0.0936508127442751,0.871228317251699,0.05986801729005234,6762]
["P48431","Transcription factor SOX-2 [OS=Homo sapiens]",3,1,1,1,317,34.3,9.74,1.83,"cell organization and biogenesis;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SOX2","ENSG00000181449","Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells","Interleukin-4 and Interleukin-13 signaling; POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation; Transcriptional Regulation by MECP2; Deactivation of the beta-catenin transactivating complex; POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation","Cell differentiation - expanded index; Cardiac progenitor differentiation; Endoderm differentiation; Dopaminergic neurogenesis; Mesodermal commitment pathway; Ectoderm differentiation; let-7 inhibition of ES cell reprogramming; Pre-implantation embryo; Wnt signaling pathway and pluripotency; Sudden infant death syndrome (SIDS) susceptibility pathways",166.7,157.2,145.6,308.6,311.1,659.5,0.3670262664165103,-1.4460447809391954,0.08180431646767912,1.0872237798416886,0.28444707376891853,0.545998529649939,2102]
["P48553","Trafficking protein particle complex subunit 10 [OS=Homo sapiens]",3,4,7,4,1259,142.1,6.04,17.74,"transport","cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","TRAPPC10","ENSG00000160218","","COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs","",616.2,603.2,580.9,785.4,660.6,932,0.7570647603027755,-0.4015113793903422,0.07164637908936343,1.1448057533649663,0.2652803367599581,0.5762949398146112,1974]
["P48723","Heat shock 70 kDa protein 13 [OS=Homo sapiens]",22,9,30,9,471,51.9,5.76,85.01,"stress response;other biological processes","mitochondrion;ER/Golgi;other cell component","other molecular function","HSPA13","ENSG00000155304","","Regulation of HSF1-mediated heat shock response","",2944.5,3021.4,3030.4,3625.2,3624.9,6151.5,0.6712855181470869,-0.575001575850362,0.15633308071926066,0.8059491137678187,0.3878609935427957,0.4113238943904579,2946]
["P48729-3","Isoform 3 of Casein kinase I isoform alpha [OS=Homo sapiens]",24,8,14,1,325,37.5,9.48,22.4,"","","","CSNK1A1","","","","",64.2,55.3,65.7,71.2,71.7,78.4,0.8368730230456394,-0.25691935254077525,0.0393302381667731,1.4052734236842743,0.19462742773252847,0.710795957112251,1477]
["P49116-1","Nuclear receptor subfamily 2 group C member 2 [OS=Homo sapiens]",8,4,8,4,596,65.4,6.28,19.2,"developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NR2C2","ENSCANG00000032916; ENSG00000177463; ENSMLEG00000044042; ENSMMUG00000005156; ENSPPAG00000023138","","Nuclear Receptor transcription pathway","Androgen receptor signaling pathway; Nuclear receptors; Hypothesized pathways in pathogenesis of cardiovascular disease; Epithelial to mesenchymal transition in colorectal cancer; Androgen receptor signaling pathway; Nuclear receptors",737.8,694.2,680,819.6,786.9,727.9,0.9047292666209733,-0.14444195367207507,0.08126896479352662,1.0900752722678708,0.2835297678643848,0.547401337686212,2095]
["P49137","MAP kinase-activated protein kinase 2 [OS=Homo sapiens]",17,7,14,5,400,45.5,8.68,31.3,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","MAPKAPK2","ENSG00000162889","MAPK signaling pathway; Cellular senescence; VEGF signaling pathway; C-type lectin receptor signaling pathway; Neurotrophin signaling pathway; Kaposi sarcoma-associated herpesvirus infection; Viral carcinogenesis","VEGFA-VEGFR2 Pathway; Oxidative Stress Induced Senescence; activated TAK1 mediates p38 MAPK activation; Regulation of HSF1-mediated heat shock response; p38MAPK events; CREB phosphorylation; Synthesis of Leukotrienes (LT) and Eoxins (EX); Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA","IL-1 signaling pathway; Microtubule cytoskeleton regulation; Interleukin-1 (IL-1) structural pathway; Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; VEGFA-VEGFR2 signaling pathway; p38 MAPK signaling pathway; Malignant pleural mesothelioma; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling",1288.9,1312.1,1349.3,1280.7,1331.5,1593.3,0.9393175603376531,-0.09031511456725742,0.43622541071145865,0.3602890397881795,0.603058734043891,0.21964038830931792,5287]
["P49356","protein farnesyltransferase subunit beta [OS=Homo sapiens]",5,2,6,2,437,48.7,5.82,28.73,"protein metabolism;other metabolic processes","cytosol;cytoskeleton;other cell component","other molecular function","FNTB","ENSG00000257365","Terpenoid backbone biosynthesis","RAS processing; Potential therapeutics for SARS; Inactivation, recovery and regulation of the phototransduction cascade","",497.1,537.6,536.8,482.9,463.5,440.3,1.13326602725896,0.1804865647390228,0.027551346812397595,1.5598571663622567,0.16452025641488072,0.7837806222878261,1224]
["P49406","39S ribosomal protein L19, mitochondrial [OS=Homo sapiens]",34,9,28,9,292,33.5,9.5,78.73,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus","other molecular function","MRPL19","ENSG00000115364","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Cytoplasmic ribosomal proteins",3387,3427.2,3545.5,3326.3,3109,2288.6,1.1875078806497095,0.24793708762171562,0.16311835141964537,0.7874971764707759,0.3950404342366428,0.403358450026374,3018]
["P49454","Centromere protein F [OS=Homo sapiens]",19,55,69,54,3210,367.5,5.07,183.38,"","","","","","","","",5378.3,5339.5,5376.5,5651.7,5906.9,7448.6,0.8467475482974873,-0.2399961903916412,0.15878494223909534,0.7991906846075071,0.390497692740763,0.4083815278120719,2972]
["P49642","DNA primase small subunit [OS=Homo sapiens]",20,5,8,5,420,49.9,8.21,27.68,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","PRIM1","ENSG00000198056","DNA replication","Activation of the pre-replicative complex; Removal of the Flap Intermediate; Polymerase switching on the C-strand of the telomere; Polymerase switching; Defective pyroptosis; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Telomere C-strand synthesis initiation; DNA replication initiation","Retinoblastoma gene in cancer; Pyrimidine metabolism; G1 to S cell cycle control; DNA replication",450.6,414.8,449.2,471.3,484.7,421.6,0.9542682926829269,-0.06753315768546525,0.4031491272017745,0.394534276090012,0.5831420880106412,0.2342256124442695,5053]
["P49736","DNA replication licensing factor mcm2 [OS=Homo sapiens]",53,38,216,38,904,101.8,5.52,634.35,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MCM2","ENSG00000073111","DNA replication; Cell cycle","Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Assembly of the pre-replicative complex; Unwinding of DNA","Cell cycle; Ciliary landscape; G1 to S cell cycle control; DNA replication",20703.8,21389.5,21457.2,21544.8,21171.9,19868.8,1.0154189069353126,0.022075028177874587,0.5978127077391955,0.22343485737577484,0.7182990433775736,0.14369471195472516,6083]
["P49750-4","Isoform 4 of YLP motif-containing protein 1 [OS=Homo sapiens]",19,36,59,35,2146,241.5,6.55,155.29,"other biological processes","cytosol;nucleus","","YLPM1","ENSG00000119596","","","",7170,6918.4,6968.4,7504.5,7360.1,8231.2,0.9117155500134222,-0.13334431281709366,0.07238637568813706,1.1403431675081295,0.26626674378691184,0.5746830727339717,1987]
["P49770","Translation initiation factor eIF-2B subunit beta [OS=Homo sapiens]",27,8,18,8,351,39,6.16,55.22,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF2B2","ENSG00000119718","Herpes simplex virus 1 infection","Recycling of eIF2:GDP","Translation factors; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Rett syndrome causing genes",1309.4,1253.1,1268.4,1291.8,1320.8,2237.3,0.7898925751046414,-0.340271633878645,0.33599100060900144,{"$f":"-LOG10(AA1987)","v":0.47367235486668274},0.5442726559067357,{"$f":"-LOG10(AC1987)","v":0.2641834839579957},4512]
["P49773","Histidine triad nucleotide-binding protein 1 [OS=Homo sapiens]",48,4,23,4,126,13.8,6.95,82.96,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","HINT1","ENSG00000169567","","","",3360.3,3436.7,3336.9,3644.3,3872.2,3459.9,0.923244415290988,-0.11521546429791939,0.08447074758754049,1.0732936621840314,0.2890433961223471,0.5390369486565773,2136]
["P49840","Glycogen synthase kinase-3 alpha [OS=Homo sapiens]",35,10,22,7,483,50.9,8.75,54.73,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function","GSK3A","ENSG00000105723","Chemokine signaling pathway; Dopaminergic synapse; Non-alcoholic fatty liver disease; Shigellosis","XBP1(S) activates chaperone genes; Constitutive Signaling by AKT1 E17K in Cancer; AKT phosphorylates targets in the cytosol; Suppression of apoptosis; Maturation of nucleoprotein; Maturation of nucleoprotein","IL-5 signaling pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; Wnt signaling pathway; Regulation of apoptosis by parathyroid hormone-related protein; Angiopoietin-like protein 8 regulatory pathway; Nonalcoholic fatty liver disease; Insulin signaling; Glycogen synthesis and degradation",1504.6,1538.2,1584,1435.5,1391.3,1338.7,1.1107430080422518,0.15152505983135753,0.01321418068674766,1.8789597590744722,0.11923758844375142,0.923586816069149,810]
["P49916-1","DNA ligase 3 [OS=Homo sapiens]",32,28,62,28,1009,112.8,9.01,209.66,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","LIG3","ENSG00000005156","Base excision repair","HDR through MMEJ (alt-NHEJ); Gap-filling DNA repair synthesis and ligation in TC-NER; Gap-filling DNA repair synthesis and ligation in GG-NER; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; Resolution of AP sites via the single-nucleotide replacement pathway","Base excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum",7678.4,7472.8,7517.5,7530.7,7751.9,9904.9,0.8999980148883374,-0.15200627557161628,0.3311411662302373,0.4799868260274327,0.541456551225236,0.2664363872753962,4470]
["P50336","protoporphyrinogen oxidase [OS=Homo sapiens]",31,11,24,11,477,50.7,8.16,62.92,"other metabolic processes;other biological processes","other membranes;mitochondrion","other molecular function","PPOX","ENSG00000143224","Porphyrin and chlorophyll metabolism; Metabolic pathways; Biosynthesis of cofactors","Heme biosynthesis","Orexin receptor pathway; Heme biosynthesis",1689.2,1700,1813.3,1556,1514.5,2134.4,0.9995388960402699,-0.000665385813845696,0.9970584621607356,1.2793762425745891E-3,0.9984244827966593,6.8477800908253652E-4,7299]
["P50443","sulfate transporter [OS=Homo sapiens]",1,1,1,1,739,81.6,8.38,2.85,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes","transporter activity","SLC26A2","ENSG00000155850","Chemical carcinogenesis","Transport and synthesis of PAPS; Multifunctional anion exchangers; Defective SLC26A2 causes chondrodysplasias","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Proteoglycan biosynthesis",47.9,43.5,32.3,45.2,45.3,71.4,0.7640518838789376,-0.3882574853261962,0.26681173801947516,0.5737950681402321,0.49407828558002126,0.3062042326517745,3947]
["P50570-1","Dynamin-2 [OS=Homo sapiens]",44,37,151,2,870,98,7.44,464.51,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","DNM2","ENSG00000079805; ENSGGOG00000005968; ENSPTRG00000034439","Phospholipase D signaling pathway; Endocytosis; Fc gamma R-mediated phagocytosis; Synaptic vesicle cycle; Endocrine and other factor-regulated calcium reabsorption; Bacterial invasion of epithelial cells; Salmonella infection","MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Recycling pathway of L1; Clathrin-mediated endocytosis; NGF-stimulated transcription; Toll Like Receptor 4 (TLR4) Cascade; NOSTRIN mediated eNOS trafficking; Retrograde neurotrophin signalling; Formation of annular gap junctions","Synaptic vesicle pathway; Fragile X syndrome; Intracellular trafficking proteins involved in CMT neuropathy",18233.1,18586.2,19132.7,16611.5,16131.8,18262,1.0969840389136032,0.13354253472222524,0.07695411124133399,1.1137681732109332,0.2750403907398093,0.5606035236703208,2045]
["P50579-2","Isoform 2 of Methionine aminopeptidase 2 [OS=Homo sapiens]",35,13,57,1,455,50.5,5.35,180.07,"","","","METAP2","","","","",73.2,69,78.4,83.8,88.2,93.6,0.8305722891566264,-0.26782235575554236,0.018784750104024656,1.7261945780381809,0.13812649749528794,0.8597230005515213,994]
["P50897","Palmitoyl-protein thioesterase 1 [OS=Homo sapiens]",20,5,15,5,306,34.2,6.52,51.73,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PPT1","ENSG00000131238","Fatty acid elongation; Metabolic pathways; Fatty acid metabolism; Lysosome","Fatty acyl-CoA biosynthesis","",1376.1,1314.4,1272.9,1611.1,1493.8,1505.9,0.859590526589746,-0.2182785117462654,0.010713224007903975,1.9700798141224198,0.10785530891703878,0.9671584729385407,726]
["P50914","60S ribosomal protein L14 [OS=Homo sapiens]",29,6,40,6,215,23.4,10.93,109.32,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","other molecular function","RPL14","ENSG00000188846","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",4702,4598,4875.1,5218,5207.7,6522.8,0.8363630999793493,-0.25779868271016737,0.10581007962567195,0.9754729587914045,0.32183348813318197,0.4923687677113316,2403]
["P51151","Ras-related protein Rab-9A [OS=Homo sapiens]",47,7,8,7,201,22.8,5.47,21.06,"transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","RAB9A","ENSG00000123595","Salmonella infection; Measles","RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Retrograde transport at the Trans-Golgi-Network; RHOBTB3 ATPase cycle","Ebola virus pathway in host",832.7,801.7,780,673.1,749.6,1054.9,0.974491443332257,-0.037278577147979795,0.8665647693362877,0.062198971421958536,0.9123771102101594,0.039825618873378744,6942]
["P51532-4","Isoform 4 of Transcription activator BRG1 [OS=Homo sapiens]",22,35,82,18,1617,181.6,8.07,239.68,"","","","SMARCA4","","","","",3541.9,3699.2,3765,4220.1,4276.1,4964.5,0.8176469277229267,-0.2904500947343006,0.030078960514323527,1.5217371764146317,0.1720243524250318,0.7644100683530402,1278]
["P51571","translocon-associated protein subunit delta [OS=Homo sapiens]",36,5,27,5,173,19,6.15,88.66,"","other membranes;ER/Golgi;other cell component","","SSR4","ENSG00000180879","Protein processing in endoplasmic reticulum","SRP-dependent cotranslational protein targeting to membrane","VEGFA-VEGFR2 signaling pathway",3919,3837.4,3884.2,4479.7,3627.5,4815.3,0.9008009286128844,-0.15071978023064,0.294284750184041,0.5312322424281413,0.5164291090264479,0.28698928628697473,4165]
["P51648","Fatty aldehyde dehydrogenase [OS=Homo sapiens]",14,7,18,7,485,54.8,7.88,52.73,"other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ALDH3A2","ENSG00000072210","Glycolysis / Gluconeogenesis; Ascorbate and aldarate metabolism; Fatty acid degradation; Valine, leucine and isoleucine degradation; Lysine degradation; Arginine and proline metabolism; Histidine metabolism; Tryptophan metabolism; beta-Alanine metabolism; Glycerolipid metabolism; Pyruvate metabolism; Pantothenate and CoA biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Alcoholic liver disease","RND2 GTPase cycle; RND1 GTPase cycle","Fragile X syndrome; Tryptophan metabolism; Fluoroacetic acid toxicity",1665.6,1727.7,1763.5,1589.3,1572.7,1107,1.2079643944717733,0.27257793092454424,0.13923849631334032,0.8562406754649183,0.3667366376771907,0.43564570103964045,2775]
["P51692","Signal transducer and activator of transcription 5B [OS=Homo sapiens]",10,8,12,8,787,89.8,6.05,26.85,"other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","STAT5B","ENSG00000173757","ErbB signaling pathway; Chemokine signaling pathway; Necroptosis; JAK-STAT signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; Prolactin signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Hepatitis B; Measles; Human T-cell leukemia virus 1 infection; Pathways in cancer; Viral carcinogenesis; Chemical carcinogenesis; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer","Interleukin-3, Interleukin-5 and GM-CSF signaling; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Growth hormone receptor signaling; Signaling by Leptin; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Signaling by cytosolic FGFR1 fusion mutants; Prolactin receptor signaling; Interleukin-20 family signaling; Erythropoietin activates STAT5; Signaling by FLT3 fusion proteins; Interleukin-2 signaling; STAT5 activation downstream of FLT3 ITD mutants; Interleukin-15 signaling; Interleukin-9 signaling; Interleukin-21 signaling; STAT5 Activation","IL-5 signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; AGE/RAGE pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Chemokine signaling pathway; IL-4 signaling pathway; White fat cell differentiation; Non-small cell lung cancer; EGF/EGFR signaling pathway; Hepatitis B infection; Endochondral ossification; Endochondral ossification with skeletal dysplasias; IL-2 signaling pathway; 3q29 copy number variation syndrome; FOXP3 in COVID-19; Familial partial lipodystrophy (FPLD); EPO receptor signaling; ErbB signaling pathway",1267.7,1321.2,1266.2,1425.5,1253.5,2078.6,0.8103035143769969,-0.3034656971759592,0.2984713287139259,0.5250973810484267,0.5196586330562374,0.2842818534108354,4198]
["P51795-2","Isoform 2 of H(+)/Cl(-) exchange transporter 5 [OS=Homo sapiens]",4,5,9,4,816,90.7,6.19,13.15,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","CLCN5","ENSG00000171365; ENSPPAG00000029912; ENSPTRG00000021899","Neutrophil extracellular trap formation","Stimuli-sensing channels","",832,781,787.2,820.8,782.3,1491.8,0.7755339429383825,-0.366738169541873,0.3726840761140858,0.4286591631987374,0.5667806725588542,0.24658496778264571,4806]
["P51946","Cyclin-H [OS=Homo sapiens]",5,2,3,2,323,37.6,7.15,2.43,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","enzyme regulator activity","CCNH","ENSG00000134480","Basal transcription factors; Nucleotide excision repair; Cell cycle","RUNX1 regulates transcription of genes involved in differentiation of HSCs; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Formation of Incision Complex in GG-NER; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry","Cell cycle; Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum",249.8,269.7,258.7,285.1,349.3,195.6,0.9375903614457832,-0.09297035614879368,0.7203660921705299,0.14244673773174465,0.8092769393904709,0.09190283479360646,6506]
["P51948-1","CDK-activating kinase assembly factor MAT1 [OS=Homo sapiens]",20,4,5,4,309,35.8,6.09,14,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","nucleus","enzyme regulator activity;kinase activity;other molecular function","MNAT1","ENSCANG00000033478; ENSCATG00000030975; ENSCSAG00000014164; ENSG00000020426; ENSMFAG00000000901; ENSMMUG00000001642; ENSNLEG00000013781; ENSPPAG00000033622; ENSPTRG00000006412; ENSRROG00000035712","Basal transcription factors; Nucleotide excision repair","RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of Incision Complex in GG-NER; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry","Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; Eukaryotic transcription initiation; G1 to S cell cycle control",186.8,156.3,178.2,215.9,220.4,250.3,0.7592484707253131,-0.3973559973612442,0.01744915664802657,1.7582255585018973,0.13495860946076846,0.8697994051271875,945]
["P52272","Heterogeneous nuclear ribonucleoprotein M [OS=Homo sapiens]",64,43,419,43,730,77.5,8.7,1152.55,"RNA metabolism OR transcription;other metabolic processes;stress response","nucleus;other cell component","nucleic acid binding activity;other molecular function","HNRNPM","ENSG00000099783","Spliceosome","mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA","mRNA processing",51734.4,51883.1,52126.1,52427.7,50947.1,50203.6,1.0140983367452716,0.02019755673571134,0.33790677376685446,0.4712031021579825,0.5452010175412669,0.2634433422868414,4530]
["P52429","Diacylglycerol kinase epsilon [OS=Homo sapiens]",8,6,11,6,567,63.9,7.74,27.76,"other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","DGKE","ENSG00000153933","Glycerolipid metabolism; Glycerophospholipid metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Phospholipase D signaling pathway; Choline metabolism in cancer","Effects of PIP2 hydrolysis","Ciliary landscape",1781.3,1825.1,1872.6,1676.9,1800.3,1397.8,1.1238974358974358,0.16851038478164412,0.17406089543906797,0.75929878662292,0.4064572155795999,0.3909851622853956,3130]
["P52565-1","rho GDP-dissociation inhibitor 1 [OS=Homo sapiens]",40,9,172,9,204,23.2,5.11,548.54,"signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","ARHGDIA; HEL-S-47e","ENSCATG00000044701; ENSG00000141522; ENSGGOG00000011564; ENSMLEG00000000660; ENSMMUG00000009949; ENSMNEG00000037888; ENSPPAG00000035710; ENSPPYG00000008748; ENSPTRG00000009773; ENSRBIG00000034513; ENSRROG00000034509","Neurotrophin signaling pathway; Vasopressin-regulated water reabsorption","CDC42 GTPase cycle; RAC1 GTPase cycle; RHOC GTPase cycle; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOH GTPase cycle; Axonal growth stimulation; Axonal growth inhibition (RHOA activation)","Ciliary landscape; Nephrotic syndrome",30677.2,30872,31219.4,28457.1,27496.4,17242,1.2674085155508195,0.3418816139548516,0.14352325006776195,0.8430777396392165,0.37238602582366775,0.4290066247410169,2817]
["P52739","Zinc finger protein 131 [OS=Homo sapiens]",10,5,6,5,623,71.4,5.19,18.71,"other biological processes","cytoskeleton;nucleus","nucleic acid binding activity;other molecular function","ZNF131","ENSG00000172262","","SUMOylation of transcription cofactors","",264.2,296,299.8,293.3,339.5,332.8,{"$f":"AVERAGE(S2114:U2114)/AVERAGE(V2114:X2114)","v":0.8906379453189729},{"$f":"LOG(Y2114,2)","v":-0.16708901627819847},{"$f":"TTEST(V2114:X2114,S2114:U2114,2,2)","v":0.12686724894875623},0.896650477484493,{"$f":"AA2114*7309/AE2114","v":0.35324675145388923},0.4519218233424958,2625]
["P52815","39S ribosomal protein L12, mitochondrial [OS=Homo sapiens]",39,5,53,5,198,21.3,8.87,149.17,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL12","ENSG00000262814","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",3060.9,2759.7,3285.1,3429.4,4231.8,3108.5,0.8454924464005498,-0.24213622918072197,0.20532361537356678,0.6875610972119452,0.44125560269491315,0.35530976726069435,3401]
["P52907","F-actin-capping protein subunit alpha-1 [OS=Homo sapiens]",69,14,178,11,286,32.9,5.69,709.15,"cell organization and biogenesis","non-structural extracellular;cytosol;cytoskeleton;other cell component","cytoskeletal activity","CAPZA1","ENSG00000116489","Endocytosis","MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Sensory processing of sound by inner hair cells of the cochlea; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Factors involved in megakaryocyte development and platelet production; Advanced glycosylation endproduct receptor signaling","",15997.4,16085.6,15632.2,15009.1,14704.6,16070,1.0421875034127868,0.05961486102152661,0.21422234250436664,0.6691352360235957,0.44992847740356773,0.3468565180862037,3480]
["P53365","Arfaptin-2 [OS=Homo sapiens]",23,4,6,3,341,37.8,6.04,24.62,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","ARFIP2","ENSG00000132254","","Retrograde transport at the Trans-Golgi-Network","",463.8,486.6,496.4,423.4,474.8,216.9,1.297462111021433,0.3756924090728603,0.2361723188869682,0.6267710062107921,0.46540401152462946,0.33216987765542927,3709]
["P53370","Nucleoside diphosphate-linked moiety X motif 6 [OS=Homo sapiens]",3,1,2,1,316,35.7,8,4.1,"other biological processes","mitochondrion;nucleus;other cell component","other molecular function","NUDT6","ENSG00000170917","","","",134.8,143.3,156.9,128.2,127.2,96.3,1.236849587716804,0.30667006599814595,0.08675843663279537,1.0616882824746665,0.29289487914508144,0.5332882212800778,2165]
["P53621-1","coatomer subunit alpha [OS=Homo sapiens]",54,57,294,57,1224,138.3,7.66,894.15,"transport;signal transduction","non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","COPA","ENSG00000122218","","COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic","",33319.9,34120.7,34404,32776.4,32277.1,28380.5,1.0900164822227456,0.12434995026939095,0.12090914704177622,0.9175408425676745,0.3456100726352532,0.461413608710037,2557]
["P53701","Cytochrome c-type heme lyase [OS=Homo sapiens]",65,16,41,16,268,30.6,6.68,118.25,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes","other membranes;mitochondrion","other molecular function","HCCS","ENSG00000004961","Porphyrin and chlorophyll metabolism; Metabolic pathways","","",3840.4,3587.8,3613.9,4182.2,4152.7,4524.2,0.8586992868863298,-0.21977510121048938,0.013530375760850425,1.8686901421608548,0.11987092901340092,0.921286128826807,825]
["P53801","pituitary tumor-transforming gene 1 protein-interacting protein [OS=Homo sapiens]",8,2,6,2,180,20.3,8.79,13.57,"transport;other biological processes","other membranes;nucleus;other cell component","other molecular function","PTTG1IP","ENSG00000183255","","","",1003.9,1017.3,997.5,781.5,865.6,472.3,1.4243182032650747,0.5102714910998477,0.06648325107343173,1.1772877514271776,0.2548117892478828,0.5937804825892103,1907]
["P54105","Methylosome subunit pICln [OS=Homo sapiens]",35,5,13,5,237,26.2,4.11,50.27,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","","CLNS1A","ENSG00000074201","","snRNP Assembly","",530.2,517.6,506.9,615,667.2,974.6,0.6888957816377173,-0.5376423509809864,0.10573295954408359,0.9757896113978242,0.32186680604236023,0.49232380957087857,2401]
["P54274-1","telomeric repeat-binding factor 1 [OS=Homo sapiens]",3,1,1,1,439,50.2,6.37,2.11,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","TERF1","ENSG00000147601","","Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Meiotic synapsis; Inhibition of DNA recombination at telomere; Packaging Of Telomere Ends; DNA Damage/Telomere Stress Induced Senescence; Telomere Extension By Telomerase; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; Removal of the Flap Intermediate from the C-strand","",53,58.8,72.5,87.5,86.9,61.5,0.781263247138618,-0.3561193476087494,0.1714366831741299,0.765896244282533,0.4038126707443492,0.39382005798272574,3103]
["P54296","Myomesin-2 [OS=Homo sapiens]",6,7,9,7,1465,164.8,6.19,23.9,"cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYOM2","ENSG00000036448; ENSG00000274137","","","",341.1,335.7,338.7,390.1,376,386.4,0.8811279826464208,-0.18257651102054748,5.3111092750919738E-4,3.27481476296022,0.02472541254245047,1.6068564534854806,157]
["P54802","alpha-N-acetylglucosaminidase [OS=Homo sapiens]",19,10,20,10,743,82.2,6.65,57.38,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;other cytoplasmic organelle","other molecular function","NAGLU","ENSG00000108784","Glycosaminoglycan degradation; Metabolic pathways; Lysosome","HS-GAG degradation; MPS IIIB - Sanfilippo syndrome B","Glycosaminoglycan degradation",1766.6,1712.6,1770.1,1615,1596.3,1945.3,1.017976961563821,0.02570491130188875,0.8012232314383962,{"$f":"-LOG10(AA2179)","v":0.09624646684322484},0.8684770278189586,{"$f":"-LOG10(AC2179)","v":0.06124166463589196},6743]
["P54852","Epithelial membrane protein 3 [OS=Homo sapiens]",10,1,3,1,163,18.4,7.96,10.84,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes","","EMP3","ENSG00000142227","","","",208.5,200.4,199.1,182.8,180.6,253.8,0.985093972780298,-0.021666738239787292,0.9053565156918448,0.04318036852046327,0.9402175011639236,0.02677166913566318,7038]
["P55039","Developmentally-regulated GTP-binding protein 2 [OS=Homo sapiens]",35,11,41,10,364,40.7,8.88,108.5,"protein metabolism;other metabolic processes;signal transduction","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DRG2","ENSG00000108591","","","",3986.9,3983.3,4180.5,3781.7,3744.8,3507.2,1.1012353063795464,0.13912276960672484,0.02603406179538891,1.5844580686288607,0.15936596119137147,0.7976044335382381,1194]
["P55145","Mesencephalic astrocyte-derived neurotrophic factor [OS=Homo sapiens]",25,6,18,6,182,20.7,8.69,39.71,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","MANF","ENSG00000145050","","Platelet degranulation","Orexin receptor pathway",1342.5,1540.4,1529.4,1561.8,1638.9,1445.8,0.9495964704616379,-0.07461352222531328,0.41176137246256933,0.3853543971866631,0.5887253269422769,0.23008728045303384,5112]
["P55197-1","Isoform 1 of Protein AF-10 [OS=Homo sapiens]",3,3,3,2,1027,109,8.38,6.62,"","","","MLLT10","","","","",211.2,188.5,232.1,299.4,316.5,265,0.7172210239527755,-0.479510316235097,0.013518073160081408,1.869085207475772,0.12019902278228103,0.9200990631318495,822]
["P55209-3","Isoform 3 of Nucleosome assembly protein 1-like 1 [OS=Homo sapiens]",47,11,262,1,323,37.3,4.67,864.92,"","","","NAP1L1","","","","",22.1,21.5,22.1,12.9,18.7,41.5,0.8987688098495215,-0.15397803563010737,0.7915634234454544,0.10151428187696955,0.8606868583699533,0.06515482812645522,6722]
["P55769","NHP2-like protein 1 [OS=Homo sapiens]",38,5,20,5,128,14.2,8.46,56.04,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SNU13","ENSG00000100138","Ribosome biogenesis in eukaryotes; Spliceosome","mRNA Splicing - Major Pathway; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; mRNA Splicing - Minor Pathway","mRNA processing",2366,2229.9,2371.9,2783.5,3096.2,2835.1,0.7995364208013954,-0.32276434146595123,0.005595271334194828,2.252178848172931,0.07760121097083492,1.1101315015015043,527]
["P55795","heterogeneous nuclear ribonucleoprotein H2 [OS=Homo sapiens]",48,18,271,7,449,49.2,6.3,653.89,"other biological processes","cytosol;nucleus;other cell component","","HNRNPH2","ENSG00000126945","","mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA","mRNA processing",7188.5,6959.1,6878.8,6924.6,7277,5944.9,1.0436750800387165,0.06167263779171819,0.513108410465542,0.28979086667605247,0.6577182343200012,0.18196011776552065,5702]
["P56181-2","Isoform 2 of NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [OS=Homo sapiens]",22,7,14,7,473,51,9.17,48.09,"","","","NDUFV3","","","","",1996.7,2088.8,1648.5,2229,1452.9,1493.4,1.1079550943906633,0.14789940989544426,0.5499827353103526,0.259650943373265,0.6843418134803144,0.16472692367607353,5874]
["P56270-2","Isoform 2 of Myc-associated zinc finger protein [OS=Homo sapiens]",10,5,11,4,493,51,9.1,40.42,"","","","MAZ","","","","",840.7,835.3,784.7,943.9,1055.7,1098.9,0.7941584637727932,-0.3325011881625564,0.012701903858776545,1.8961311787769828,0.11633861566891951,0.9342761082437392,798]
["P56937-1","3-keto-steroid reductase [OS=Homo sapiens]",21,6,13,6,341,38.2,8.1,39.26,"other metabolic processes","other membranes;ER/Golgi","other molecular function","HSD17B7","ENSG00000132196","Steroid biosynthesis; Steroid hormone biosynthesis; Metabolic pathways; Ovarian steroidogenesis","Cholesterol biosynthesis","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Steroid biosynthesis",1173.8,1116.6,1102.5,1161.9,1221.3,1879.9,0.795876240294621,-0.32938398747857434,0.27775527708035325,0.5563376811355852,0.503875234594267,0.2976769866399901,4029]
["P57678","Gem-associated protein 4 [OS=Homo sapiens]",10,10,21,10,1058,120,6.04,54.82,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","GEMIN4","ENSG00000179409","","snRNP Assembly","",2077.5,2079.6,1995.9,2318.4,2202.4,2392.4,0.8900364520048603,-0.16806367111201548,0.014832574090981175,1.828783473617583,0.1241824559346866,0.9059397554391798,873]
["P57737","Coronin-7 [OS=Homo sapiens]",52,34,178,1,925,100.5,5.8,561.51,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cell component","cytoskeletal activity","CORO7","ENSG00000262246; ENSG00000282725","","","",317,296.6,306.6,305.9,301.9,474.4,0.8503049343929034,-0.23394778487920642,0.3982161588915354,0.3998811210664133,0.5802555632651978,0.23638068700510037,5016]
["P58005-1","sestrin-3 [OS=Homo sapiens]",5,2,3,2,492,57.3,6.25,5.58,"stress response;signal transduction;other biological processes","nucleus;other cell component","other molecular function","SESN3","ENSG00000149212","p53 signaling pathway; Longevity regulating pathway","TP53 Regulates Metabolic Genes","Angiopoietin-like protein 8 regulatory pathway; miRNA regulation of p53 pathway in prostate cancer",140.3,144.1,135.3,97.3,104.8,164.7,1.1442202835332609,0.19436482429085547,0.45777088690971846,0.3393518308325209,0.6173150207422753,0.20949315548693487,5420]
["P60468","protein transport protein Sec61 subunit beta [OS=Homo sapiens]",36,4,39,4,96,10,11.56,58.02,"protein metabolism;other metabolic processes;stress response;transport","other membranes;cytosol;ER/Golgi","translation activity;other molecular function","SEC61B","ENSG00000106803","Protein export; Protein processing in endoplasmic reticulum; Phagosome; Vibrio cholerae infection","ER-Phagosome pathway; SRP-dependent cotranslational protein targeting to membrane; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",4672.2,4583.4,4602.6,4022.2,4432.7,3268.9,1.182057012231529,0.24129962035480196,0.10587578648324185,0.9752033505543805,0.3217655398777608,0.492460469380258,2405]
["P60520","Gamma-aminobutyric acid receptor-associated protein-like 2 [OS=Homo sapiens]",35,5,6,5,117,13.7,8.1,15.85,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","GABARAPL2","ENSG00000034713","FoxO signaling pathway; Autophagy; Mitophagy; Autophagy; NOD-like receptor signaling pathway; GABAergic synapse","TBC/RABGAPs; Macroautophagy","Network map of SARS-CoV-2 signaling pathway; Senescence and autophagy in cancer",697.8,702,704.5,1131.2,1150,1962.8,0.49582940622054666,-1.0120842588187176,0.05993249112531098,1.2223376702512627,0.24201468377618673,0.6161582832364743,1810]
["P60891","ribose-phosphate pyrophosphokinase 1 [OS=Homo sapiens]",58,17,100,8,318,34.8,6.98,299.06,"other metabolic processes;developmental processes","cytosol;other cell component","kinase activity;other molecular function","PRPS1","ENSG00000147224","Pentose phosphate pathway; Purine metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids","5-Phosphoribose 1-diphosphate biosynthesis","Nucleotide metabolism",13640.6,14604.9,14928.3,12683.6,11950.9,10499,1.2288499580172771,0.29730877410033335,0.023248119062029927,1.6336121788611693,0.15104044642166822,0.8209067394245775,1125]
["P60953","Cell division control protein 42 homolog [OS=Homo sapiens]",48,8,143,2,191,21.2,6.55,517.75,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","CDC42","ENSG00000070831","MAPK signaling pathway; Ras signaling pathway; Rap1 signaling pathway; Chemokine signaling pathway; Endocytosis; Axon guidance; VEGF signaling pathway; Focal adhesion; Adherens junction; Tight junction; T cell receptor signaling pathway; Fc gamma R-mediated phagocytosis; Leukocyte transendothelial migration; Neurotrophin signaling pathway; Regulation of actin cytoskeleton; GnRH signaling pathway; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Bacterial invasion of epithelial cells; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Human papillomavirus infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; Renal cell carcinoma; Pancreatic cancer; Lipid and atherosclerosis","RHO GTPases Activate Formins; MAPK6/MAPK4 signaling; RHO GTPases activate IQGAPs; RAC1 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; GPVI-mediated activation cascade; CDC42 GTPase cycle; RHOG GTPase cycle; RAC3 GTPase cycle; RHOQ GTPase cycle; RAC2 GTPase cycle; RHOJ GTPase cycle; EPHB-mediated forward signaling; DCC mediated attractive signaling; Myogenesis; G beta:gamma signalling through CDC42; EGFR downregulation; RHO GTPases activate PAKs; Inactivation of CDC42 and RAC1; CD28 dependent Vav1 pathway; RHO GTPases activate KTN1","Androgen receptor signaling pathway; Target of rapamycin (TOR) signaling; Integrin-mediated cell adhesion; Integrated breast cancer pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; Microtubule cytoskeleton regulation; Metastatic brain tumor; Pathogenic Escherichia coli infection; RalA downstream regulated genes; B cell receptor signaling pathway; AGE/RAGE pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Focal adhesion; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; Oxidative damage response; p38 MAPK signaling pathway; Ebola virus pathway in host; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Hippo signaling regulation pathways; 22q11.2 copy number variation syndrome; Gastrin signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent)",13526.6,13806,13860.3,11551.8,12429.2,6408.7,1.3554888662935138,0.43881326322424047,0.12802917335600592,0.8926910586027741,0.3539202829270224,0.4510945475324038,2644]
["P61020","Ras-related protein Rab-5B [OS=Homo sapiens]",66,9,33,6,215,23.7,8.13,109.45,"transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","RAB5B","ENSG00000111540","Ras signaling pathway; Endocytosis; Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection; Amoebiasis; Tuberculosis","RAB geranylgeranylation; Neutrophil degranulation; Clathrin-mediated endocytosis; RAB GEFs exchange GTP for GDP on RABs; TBC/RABGAPs","Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells",1368.5,1329.2,1325.2,1114.8,1176.2,1743.8,0.9970506592643995,-4.2612863393389384E-3,0.9851777526937799,0.006485403969982904,0.9910080091437982,3.9228356127058266E-3,7266]
["P61160-1","Actin-related protein 2 [OS=Homo sapiens]",36,11,110,11,394,44.7,6.74,332.6,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","Actr2; ACTR2; LOC111147990","ENSAMEG00000015749; ENSANAG00000038066; ENSBIXG00000015264; ENSBIXG00005008678; ENSBTAG00000009761; ENSCAFG00000003197; ENSCATG00000036025; ENSCCAG00000030047; ENSCHIG00000014272; ENSCJAG00000006722; ENSCPOG00000025808; ENSDLEG00000013424; ENSECAG00000009219; ENSFCAG00000004960; ENSG00000138071; ENSHGLG00000013085; ENSLAFG00000010273; ENSLCNG00005006073; ENSMFAG00000044097; ENSMLEG00000038155; ENSMLUG00000005227; ENSMMUG00000002263; ENSMNEG00000044163; ENSMPUG00000006176; ENSMUSG00000020152; ENSNLEG00000009948; ENSOANG00000039143; ENSOCUG00000004906; ENSPANG00000007073; ENSPCOG00000025808; ENSPCTG00005007920; ENSPPAG00000030634; ENSPPYG00000012359; ENSPTRG00000011990; ENSRBIG00000040326; ENSRFEG00010007536; ENSRROG00000043956; ENSSBOG00000028028; ENSSSUG00005000856; ENSSTOG00000012608; ENSTSYG00000034470; ENSVURG00010013014; ENSVVUG00000027598","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Salmonella infection; Yersinia infection; Pathogenic Escherichia coli infection; Shigellosis","Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; EPHB-mediated forward signaling; Regulation of actin dynamics for phagocytic cup formation; Neutrophil degranulation; EPHB-mediated forward signaling; Clathrin-mediated endocytosis; RHO GTPases Activate WASPs and WAVEs","ESC pluripotency pathways; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways",14365.6,14577.1,14906.3,13217.8,13253.1,13396.9,1.099860037423685,0.1373199454207713,0.001345075284385251,2.8712534073507343,0.04012716430029306,1.3965615298312937,245]
["P61201-1","COP9 signalosome complex subunit 2 [OS=Homo sapiens]",44,17,60,1,443,51.6,5.53,181.37,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","Cops2; COPS2; LOC101356833; LOC111162519","ENSACCG00020011181; ENSANAG00000033255; ENSBIXG00000019496; ENSBIXG00005014970; ENSCHIG00000021490; ENSCPOG00000003447; ENSCSAG00000010648; ENSDLEG00000002228; ENSG00000166200; ENSGALG00000000404; ENSLSDG00000017105; ENSMMUG00000009838; ENSMPUG00000012327; ENSMUSG00000027206; ENSOARG00000021006; ENSPPYG00000006460; ENSPSIG00000010252; ENSRNOG00000008744; ENSSHBG00005020299; ENSSSCG00000004652; ENSSSCG00070002171; ENSSTOG00000005348; ENSUMAG00000014609","","Cargo recognition for clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER; Formation of TC-NER Pre-Incision Complex; RHOBTB1 GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; Neddylation; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER; RHOBTB1 GTPase cycle; Neddylation; DNA Damage Recognition in GG-NER; Formation of TC-NER Pre-Incision Complex; Cargo recognition for clathrin-mediated endocytosis; RHOBTB1 GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; Neddylation; Formation of TC-NER Pre-Incision Complex; RHOBTB1 GTPase cycle; DNA Damage Recognition in GG-NER","Ciliary landscape",5342.6,5426.4,5542.7,5809.3,5670.5,4886.1,0.9966882359051442,-4.7857947292048114E-3,0.9538229701294225,0.020532223021530644,0.9728568362651339,0.011951064967649468,7166]
["P61313-1","60S ribosomal protein L15 [OS=Homo sapiens]",50,12,68,12,204,24.1,11.62,207.71,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;cytoskeleton;translational apparatus;nucleus","nucleic acid binding activity;other molecular function","LOC111155115; NR1D2; Rpl15; RPL15","ENSAMEG00000003497; ENSAMEG00000024645; ENSBIXG00000012476; ENSBIXG00005007092; ENSBMUG00000012295; ENSBTAG00000033080; ENSCAFG00000005764; ENSCAFG00030022972; ENSCAFG00040022162; ENSCANG00000040764; ENSCATG00000039291; ENSCGRG00001021972; ENSCGRG00015016653; ENSCJAG00000043224; ENSCPOG00000030042; ENSCSAG00000009762; ENSECAG00000010157; ENSFCAG00000026237; ENSG00000174748; ENSGGOG00000024274; ENSHGLG00000000795; ENSLCNG00005011910; ENSMFAG00000043886; ENSMLEG00000031741; ENSMLUG00000013809; ENSMMUG00000006353; ENSMPUG00000012148; ENSMUSG00000012405; ENSNLEG00000003580; ENSOANG00000045456; ENSOCUG00000010961; ENSOGAG00000013056; ENSPANG00000015926; ENSPPAG00000032386; ENSPPYG00000014065; ENSPTRG00000014695; ENSRBIG00000024014; ENSRBIG00000033415; ENSRFEG00010011144; ENSRNOG00000008140; ENSRROG00000001983; ENSRROG00000015533; ENSRROG00000027506; ENSRROG00000028991; ENSRROG00000037650; ENSSHAG00000031281; ENSSSCG00000037030; ENSSSCG00070018008; ENSSSUG00005002593; ENSSTOG00000011153; ENSUAMG00000015536; ENSVURG00010022414; ENSVVUG00000028235","Ribosome; Coronavirus disease","L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Formation of a pool of free 40S subunits; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins; Cytoplasmic ribosomal proteins; Cytoplasmic ribosomal proteins",12229.7,11013,10805.5,12974.8,14214.9,14247.5,0.8216819669282673,-0.2833479899321417,0.01568286684021539,1.8045745450265298,0.12707990436267658,0.8959231206844988,902]
["P61626","lysozyme c [OS=Homo sapiens]",6,1,1,1,148,16.5,9.16,2.6,"other metabolic processes;stress response;other biological processes","non-structural extracellular;other cytoplasmic organelle;other cell component","other molecular function","LYZ","ENSG00000090382","Salivary secretion","Neutrophil degranulation; Amyloid fiber formation; Antimicrobial peptides","Macrophage markers",135.5,298.6,79,182,101.8,59.1,1.4963546223388742,0.5814521212557815,0.49174621511543865,0.3082589740843867,0.6422753906859795,0.1922787180202037,5596]
["P61769","Beta-2-microglobulin [OS=Homo sapiens]",8,1,2,1,119,13.7,6.52,6.3,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","B2M","ENSG00000166710; ENSG00000273686","Antigen processing and presentation; Human cytomegalovirus infection; Human T-cell leukemia virus 1 infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection","ER-Phagosome pathway; Neutrophil degranulation; DAP12 signaling; Amyloid fiber formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Modulation by Mtb of host immune system; Nef mediated downregulation of MHC class I complex cell surface expression; Endosomal/Vacuolar pathway","IL-18 signaling pathway",205,198,148,195.3,155.6,152.7,1.0941223193010325,0.1297740357395034,0.5230740282149088,0.28143684312104295,0.6646641293850432,0.1773977586118962,5752]
["P61962","DDB1- and CUL4-associated factor 7 [OS=Homo sapiens]",17,5,9,5,342,38.9,5.52,25.48,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","DCAF7","ENSG00000136485","","Neddylation; Association of TriC/CCT with target proteins during biosynthesis","Ciliary landscape",1017.7,1111.1,968.4,945.7,1042,1795.7,0.8186287466300153,-0.28871876613178715,0.4476623337589541,0.3490494455513571,0.6099858309925793,0.21468025284694542,5364]
["P61970","nuclear transport factor 2 [OS=Homo sapiens]",74,6,40,6,127,14.5,5.38,113.91,"transport;other biological processes","other membranes;cytosol;nucleus","other molecular function","NUTF2","ENSG00000102898","","","",6333.4,6422.4,6931.5,5978.4,6305.2,5754.3,1.091440799649627,0.1262338798768944,0.08871798646373655,1.051988323459569,0.29528222361723605,0.5297626973536503,2196]
["P62136-1","serine/threonine-protein phosphatase PP1-alpha catalytic subunit [OS=Homo sapiens]",59,15,107,4,330,37.5,6.33,384.55,"cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","LOC111149674; Ppp1ca; PPP1CA","ENSAMEG00000000758; ENSANAG00000023829; ENSBIXG00000010347; ENSBIXG00005003445; ENSBTAG00000012146; ENSCAFG00000041420; ENSCATG00000031120; ENSCCAG00000020614; ENSCHIG00000012800; ENSCJAG00000000983; ENSCPOG00000032835; ENSCSAG00000008548; ENSECAG00000010532; ENSFCAG00000028502; ENSG00000172531; ENSGGOG00000009981; ENSHGLG00000013028; ENSLCNG00005013643; ENSMLUG00000005112; ENSMMUG00000017278; ENSMNEG00000042253; ENSMPUG00000003801; ENSNLEG00000006360; ENSOARG00000011318; ENSOGAG00000033516; ENSPANG00000009836; ENSPCOG00000026258; ENSPCTG00005022585; ENSPPYG00000002995; ENSRFEG00010000614; ENSRNOG00000018708; ENSSHAG00000030720; ENSSSCG00000012913; ENSSSCG00070006658; ENSVURG00010024750; ENSVVUG00000010423","mRNA surveillance pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Oocyte meiosis; Cellular senescence; Adrenergic signaling in cardiomyocytes; Vascular smooth muscle contraction; Hippo signaling pathway; Focal adhesion; Platelet activation; Long-term potentiation; Dopaminergic synapse; Inflammatory mediator regulation of TRP channels; Regulation of actin cytoskeleton; Insulin signaling pathway; Oxytocin signaling pathway; Insulin resistance; Amphetamine addiction; Alcoholism; Herpes simplex virus 1 infection; Proteoglycans in cancer; Diabetic cardiomyopathy","DARPP-32 events; Circadian Clock; Triglyceride catabolism; Downregulation of TGF-beta receptor signaling; DARPP-32 events; DARPP-32 events","Sphingolipid pathway; Nicotine effect on dopaminergic neurons; Common pathways underlying drug addiction; Vascular smooth muscle contraction; Focal adhesion; VEGFA-VEGFR2 signaling pathway; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Netrin-UNC5B signaling pathway; Neuroinflammation and glutamatergic signaling",3114.3,3045.8,3189.9,3137.1,3261,2542.7,1.045767716535433,0.06456243914026064,0.5779932759424743,0.23807721389446312,0.7053853487833602,0.15157356509469894,5989]
["P62256","ubiquitin-conjugating enzyme E2 H [OS=Homo sapiens]",28,6,8,6,183,20.6,4.67,23.56,"protein metabolism;other metabolic processes","cytosol;nucleus","other molecular function","UBE2H","ENSG00000186591","Ubiquitin mediated proteolysis","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation","Ciliary landscape",1475.6,1562.5,1603.1,1962.5,1783.9,832,1.0137165822121266,0.019654355900997168,0.9555421440341219,0.019750153697576794,0.9736592124279098,0.011593022649041048,7173]
["P62266","40S ribosomal protein S23 [OS=Homo sapiens]",52,7,57,7,143,15.8,10.49,177.3,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytosol;ER/Golgi;translational apparatus;nucleus;other cell component","other molecular function","RPS23","ENSG00000186468","Ribosome; Coronavirus disease","Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",7968.5,7830.6,7716.9,8889.7,8621.3,8194.3,0.9148307936495588,-0.1284231665035364,0.027481025441535707,1.560967065815854,0.16423451754062507,0.7845355609681667,1223]
["P62312","U6 snRNA-associated Sm-like protein LSm6 [OS=Homo sapiens]",43,4,6,4,80,9.1,9.58,13.28,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","LSM6","ENSG00000164167","RNA degradation; Spliceosome","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease","",1220.1,1310.6,1370.5,1337.1,1379.1,1448.8,0.9366626650660264,-0.09439853372876036,0.1820494605464624,0.7398106036404561,0.4151636527719481,0.38178067561131945,3205]
["P62487","DNA-directed RNA polymerase II subunit rpb7 [OS=Homo sapiens]",38,5,9,5,172,19.3,5.54,24.31,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POLR2G","ENSG00000168002","RNA polymerase; Huntington disease","FGFR2 alternative splicing; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere","Pyrimidine metabolism; Eukaryotic transcription initiation",777.4,808.5,891.4,996.7,965.9,1294.6,0.7605612182242417,-0.39486371850368507,0.07773462424109823,1.1093854964183145,0.27634356448355396,0.5585506448575798,2056]
["P62633-1","Cellular nucleic acid-binding protein [OS=Homo sapiens]",50,9,54,1,177,19.5,7.71,136.79,"DNA metabolism;other metabolic processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","Cnbp; CNBP; LOC101344172; LOC111159043; LOC113917796","ENSAMEG00000015334; ENSBIXG00000009042; ENSBMUG00000014129; ENSCAFG00000004320; ENSCANG00000042967; ENSCATG00000020089; ENSCCAG00000034056; ENSCGRG00001000923; ENSCJAG00000017430; ENSCPOG00000032294; ENSCSAG00000008817; ENSDLEG00000010302; ENSECAG00000009512; ENSFCAG00000042197; ENSG00000169714; ENSHGLG00000002069; ENSLAFG00000002502; ENSLCNG00005005148; ENSMFAG00000030262; ENSMLEG00000041892; ENSMMUG00000058753; ENSMNEG00000028473; ENSMPUG00000017315; ENSNLEG00000035879; ENSOCUG00000008696; ENSPANG00000007815; ENSPCTG00005021559; ENSPPYG00000013423; ENSPTRG00000015369; ENSRBIG00000030361; ENSRNOG00000010239; ENSRROG00000045469; ENSSBOG00000023735; ENSSSCG00070013675; ENSSTOG00000000173; ENSTSYG00000004344; ENSTTRG00000015266; ENSVVUG00000018264","","","",5345.8,4902.5,4646.5,8275.2,7904.2,6269.5,0.6634979887655965,-0.5918360024679264,0.017851712790576325,1.7483201089741949,0.13605648465727044,0.8662807542608855,959]
["P62753","40S RIBOSOMAL PROTEIN S6 [OS=Homo sapiens]",43,13,163,13,249,28.7,10.84,526.71,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;ER/Golgi;translational apparatus;nucleus;other cell component","other molecular function","RPS6","ENSG00000137154","EGFR tyrosine kinase inhibitor resistance; Ribosome; HIF-1 signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Apelin signaling pathway; Thermogenesis; Insulin signaling pathway; Coronavirus disease; Proteoglycans in cancer","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); mTORC1-mediated signalling; rRNA modification in the nucleus and cytosol; Nuclear events stimulated by ALK signaling in cancer","IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Thermogenesis; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Cytoplasmic ribosomal proteins; EGFR tyrosine kinase inhibitor resistance; IL-2 signaling pathway; Malignant pleural mesothelioma; Interferon type I signaling pathways",18488.9,17725.5,16243.2,18514.7,17848.3,17554.3,0.9729270568073699,-0.039596448901587505,0.5350842581971246,0.27157782547629034,0.6736015920018573,0.17159689508797227,5806]
["P62826","GTP-binding nuclear protein RAN [OS=Homo sapiens]",66,10,91,10,216,24.4,7.49,277.36,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;other biological processes","cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RAN","ENSG00000132341","Ribosome biogenesis in eukaryotes; Nucleocytoplasmic transport; Human T-cell leukemia virus 1 infection","Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Nuclear import of Rev protein; Transcriptional regulation by small RNAs; tRNA processing in the nucleus; Regulation of cholesterol biosynthesis by SREBP (SREBF); MicroRNA (miRNA) biogenesis; Postmitotic nuclear pore complex (NPC) reformation","Androgen receptor signaling pathway; miRNA biogenesis; 22q11.2 copy number variation syndrome",12714.3,12689.1,12850.4,11756.3,11128.9,11932.9,1.098675688794047,0.13576558900111574,0.010042067780758765,1.9981768516023644,0.10500353849723293,0.9787960654640728,699]
["P62854","40S ribosomal protein S26 [OS=Homo sapiens]",21,2,7,2,115,13,11,24.57,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;translational apparatus;nucleus","nucleic acid binding activity;other molecular function","RPS26","ENSG00000197728","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Peptide chain elongation; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",671.9,676.1,568.6,719.6,669.4,815.8,0.8692851959361393,-0.20209851938878776,0.1585322237127216,0.7998824485362245,0.39040162503917863,0.408488383259241,2968]
["P62913","60S ribosomal protein L11 [OS=Homo sapiens]",49,8,53,8,178,20.2,9.6,142.44,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;translational apparatus;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","RPL11","ENSG00000142676","Ribosome; Coronavirus disease","Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",7874.9,8126.9,8538.7,9705.4,9531.4,4948.7,1.0146782162866181,0.021022279754267233,0.9435147175135776,0.02525132105805061,0.9666595276572385,0.014726464176412823,7134]
["P62937-2","Isoform 2 of Peptidyl-prolyl cis-trans isomerase A [OS=Homo sapiens]",90,12,899,1,105,11.4,7.9,1952.98,"","","","PPIA","","","","",479.7,780.6,840.9,461.9,292.7,159.7,2.2981515913813846,1.2004739646163256,0.04937681789659217,1.3064769017366227,0.2199239256588618,0.6577275209057429,1641]
["P63027","Vesicle-associated membrane protein 2 [OS=Homo sapiens]",34,4,16,1,116,12.7,8.13,54.84,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","VAMP2","ENSG00000220205","SNARE interactions in vesicular transport; Synaptic vesicle cycle; Insulin secretion; Vasopressin-regulated water reabsorption; Salivary secretion","Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; GABA synthesis, release, reuptake and degradation; Cargo recognition for clathrin-mediated endocytosis; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Sensory processing of sound by inner hair cells of the cochlea; Lysosome Vesicle Biogenesis; trans-Golgi Network Vesicle Budding; Golgi Associated Vesicle Biogenesis; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; Regulation of insulin secretion; Insulin processing; Other interleukin signaling; Toxicity of tetanus toxin (tetX); Toxicity of botulinum toxin type B (botB); Toxicity of botulinum toxin type D (botD); Toxicity of botulinum toxin type G (botG); Toxicity of botulinum toxin type F (botF)","Synaptic vesicle pathway; Insulin signaling; 7q11.23 copy number variation syndrome; Galanin receptor pathway; Sudden infant death syndrome (SIDS) susceptibility pathways",1292,1145,1207.3,1288,1639.9,2775.2,0.6390033490557766,-0.6461046024420113,0.20254498181871747,0.6934785122702601,0.4381181628034939,0.3584087421611835,3379]
["P63208","s-phase kinase-associated protein 1 [OS=Homo sapiens]",63,10,50,10,163,18.6,4.54,140.14,"protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","SKP1","ENSG00000113558","Cell cycle; Oocyte meiosis; Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum; Wnt signaling pathway; TGF-beta signaling pathway; Circadian rhythm; Shigellosis; Salmonella infection; Human immunodeficiency virus 1 infection; Pathways in cancer","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Regulation of RUNX2 expression and activity; Circadian Clock; Antigen processing: Ubiquitination & Proteasome degradation; Nuclear events stimulated by ALK signaling in cancer; SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Neddylation; SCF(Skp2)-mediated degradation of p27/p21; Negative regulation of NOTCH4 signaling; Regulation of PLK1 Activity at G2/M Transition; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Cyclin D associated events in G1; Regulation of BACH1 activity; MAP3K8 (TPL2)-dependent MAPK1/3 activation; NOTCH1 Intracellular Domain Regulates Transcription; Prolactin receptor signaling; Iron uptake and transport; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling","Cell cycle; TNF-alpha signaling pathway; TGF-beta signaling pathway; Breast cancer pathway; Small cell lung cancer; Notch signaling pathway (Netpath)",3770.4,3616,4175.6,5491.8,6301.1,4832,0.695462829851608,-0.5239546852553931,0.020880168623407133,1.6802659983939356,0.1449317687260045,0.8388364076954493,1053]
["P63279","SUMO-conjugating enzyme ubc9 [OS=Homo sapiens]",25,2,5,2,158,18,8.66,15.5,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","UBE2I","ENSG00000103275","Nucleocytoplasmic transport; NF-kappa B signaling pathway; Ubiquitin mediated proteolysis; MicroRNAs in cancer","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; Formation of Incision Complex in GG-NER; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; SUMOylation of intracellular receptors; Vitamin D (calciferol) metabolism; SUMOylation of transcription factors; Postmitotic nuclear pore complex (NPC) reformation; Negative regulation of activity of TFAP2 (AP-2) family transcription factors; Maturation of nucleoprotein; SUMOylation of immune response proteins; Maturation of nucleoprotein; SUMO is transferred from E1 to E2 (UBE2I, UBC9)","Androgen receptor signaling pathway; TGF-beta signaling pathway",606.9,564.2,573.2,740,735.9,271.4,0.9982830653007495,-2.4791420481803297E-3,0.9951942957251486,2.0921219440433176E-3,0.9976512285633125,1.0212582954147358E-3,7291]
["P67936","Tropomyosin alpha-4 chain [OS=Homo sapiens]",59,19,105,8,248,28.5,4.69,249.85,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","cytoskeletal activity;other molecular function","TPM4","ENSG00000167460","Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Hypertrophic cardiomyopathy; Dilated cardiomyopathy","Smooth Muscle Contraction; Striated Muscle Contraction; RHOV GTPase cycle; Signaling by ALK fusions and activated point mutants","Striated muscle contraction pathway",4306.6,4234.8,4951.6,5573.3,7100.9,6903,0.6892201131928979,-0.5369632912057428,0.018792119954311133,1.7260242240226422,0.13804181381513575,0.8599893428843947,995]
["P68133","Actin, alpha skeletal muscle [OS=Homo sapiens]",40,18,1223,3,377,42,5.39,3506.87,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ACTA1","ENSG00000143632","","Striated Muscle Contraction","Myometrial relaxation and contraction pathways; Fas ligand pathway and stress induction of heat shock proteins; Physico-chemical features and toxicity-associated pathways; Striated muscle contraction pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; IL-18 signaling pathway; Malignant pleural mesothelioma",43755.3,42390.8,41527.5,36132.3,36751.4,30290.6,1.2374554515998653,0.3073765891010992,0.019362810548360938,1.7130316037913964,0.14067871003774363,0.8517716226273321,1006]
["P69905","Hemoglobin subunit alpha [OS=Homo sapiens]",22,3,75,3,142,15.2,8.68,198.38,"other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;cytosol;translational apparatus;other cell component","other molecular function","HBA1; HBA2","ENSG00000188536; ENSG00000206172","African trypanosomiasis; Malaria","Heme signaling; Scavenging of heme from plasma; Cytoprotection by HMOX1; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Effects of nitric oxide",9454.9,8780.9,9697.2,7865.2,8607.6,9512.5,1.0749539162526505,0.10427481216928204,0.3028923504419802,0.518711694652576,0.523490231586766,0.28109141791550346,4229]
["P78345","Ribonuclease P protein subunit p38 [OS=Homo sapiens]",18,4,6,4,283,31.8,9.92,14.17,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RPP38","ENSG00000152464","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus","Integrated breast cancer pathway; Sphingolipid metabolism in senescence",314.2,295.3,319,354.4,394.1,646.7,0.6654959862385321,-0.5874981299541432,0.16547330157450227,0.7812720678352084,0.3961494795964746,0.4021409102498973,3053]
["P78356","Phosphatidylinositol 5-phosphate 4-kinase type-2 beta [OS=Homo sapiens]",31,11,34,6,416,47.3,7.33,83,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle","kinase activity;other molecular function","PIP4K2B","ENSG00000276293; ENSG00000277292","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Regulation of actin cytoskeleton","Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs in the nucleus","Regulation of actin cytoskeleton",1477.7,1463.3,1395.6,1416.7,1369,1797.6,0.9461741539938475,-0.07982234263446727,0.5832205097456435,0.2341672118630272,0.7092776548637119,0.14918372198179378,6010]
["P78410-1","Butyrophilin subfamily 3 member A2 [OS=Homo sapiens]",25,6,11,4,334,36.4,5.33,34.54,"signal transduction;other biological processes","plasma membrane;other membranes","signal transduction activity or receptor binding","BTN3A2","ENSG00000186470","","Butyrophilin (BTN) family interactions","",1002.7,1031.6,1075.9,1023.1,1030.7,2349.8,0.706285766191298,-0.5016760727903412,0.384086459998367,0.4155710025240751,0.5718655400546067,0.24270607273997158,4909]
["P80297","metallothionein-1X [OS=Homo sapiens]",20,1,1,1,61,6.1,7.96,2.54,"stress response;other biological processes","nucleus;other cell component","other molecular function","MT1X","ENSG00000187193","Mineral absorption","Metallothioneins bind metals","Copper homeostasis; Zinc homeostasis; Oxidative stress response",54.8,56,51.8,37.4,43.8,45.9,1.2793076317859953,0.35536322707006884,0.014153930806385266,1.8491229318393179,0.1219941984243749,0.9136608222120587,848]
["P80303","Nucleobindin-2 [OS=Homo sapiens]",8,3,4,3,420,50.2,5.12,11.01,"","","","","","","","",417.9,337.5,383.2,549.9,675.7,1040.7,0.5024048007765961,-0.993077844783029,0.06517703979852402,1.185905368147654,0.25205237242720213,0.5985092104369252,1890]
["P82673-1","28S ribosomal protein S35, mitochondrial [OS=Homo sapiens]",30,9,16,8,323,36.8,8.24,39.55,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPS35","ENSG00000061794","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1658.8,1641.6,1799.5,2088.7,2153.6,1718,0.8556448500914383,-0.2249159890690008,0.11835350248786337,0.9268188852748704,0.3421858187040322,0.4657379930012449,2528]
["P82912-1","28S ribosomal protein S11, mitochondrial [OS=Homo sapiens]",34,4,10,4,194,20.6,10.81,31.36,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes","other membranes;cytosol;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPS11","ENSG00000181991","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",937.6,929.2,941.2,924.6,883.1,973.7,1.009563529157978,0.013731698502333023,0.7540767613253955,0.12258444282623061,0.8343244094046799,0.07866505029765308,6606]
["P82987-1","ADAMTS-like protein 3 [OS=Homo sapiens]",1,1,1,1,1691,188.6,7.83,0,"cell organization and biogenesis;protein metabolism","non-structural extracellular;extracellular matrix;other cell component","other molecular function","ADAMTSL3","ENSG00000156218","","Defective B3GALTL causes PpS; O-glycosylation of TSR domain-containing proteins","",34.6,26.1,29.5,24.2,24.2,2.5,1.7721021611001966,0.8254617771796857,0.161702997419446,0.7912819296875373,0.39356883387903124,0.40497930000254534,3003]
["P84077","ADP-ribosylation factor 1 [OS=Homo sapiens]",73,11,196,5,181,20.7,6.8,662.51,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","ARF1","ENSG00000143761","Phospholipase D signaling pathway; Endocytosis; Vibrio cholerae infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Legionellosis","COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; COPI-mediated anterograde transport; Synthesis of PIPs at the plasma membrane; Intra-Golgi traffic; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis; trans-Golgi Network Vesicle Budding; Synthesis of PIPs at the Golgi membrane; Nef Mediated CD4 Down-regulation","Cell migration and invasion through p75NTR; Neural crest cell migration during development; Neural crest cell migration in cancer; Insulin signaling",15788,16947.3,16248.2,14093.5,15437.3,15953.2,1.0769391434350541,0.10693672718474635,0.1465496079987926,0.8340153389054431,0.37702607703737245,0.42362861074440594,2841]
["P84095","Rho-related GTP-binding protein RhoG [OS=Homo sapiens]",60,8,48,7,191,21.3,8.12,179.23,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","RHOG","ENSG00000177105","Bacterial invasion of epithelial cells; Salmonella infection; Yersinia infection","Neutrophil degranulation; RHOG GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; RHO GTPases activate KTN1","Brain-derived neurotrophic factor (BDNF) signaling pathway",3541,3578.4,3665.7,2939.9,2946.6,2889.9,1.2288751652158059,0.29733836756460613,8.267404986141483E-5,4.082630787552037,0.012856694264618745,1.8908706836037812,47]
["P98155-1","very low-density lipoprotein receptor [OS=Homo sapiens]",1,1,1,1,873,96,4.79,1.97,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","VLDLR","ENSG00000147852","Spinocerebellar ataxia; Lipid and atherosclerosis","VLDLR internalisation and degradation; Reelin signalling pathway; VLDL clearance","Familial hyperlipidemia type 3",20.6,27.2,16.9,30.1,24,29.4,0.7748502994011975,-0.3680104853689072,0.1545918309939292,{"$f":"-LOG10(AA2499)","v":0.810813458981688},0.38708862375287034,{"$f":"-LOG10(AC2499)","v":0.41218959208572936},2919]
["P99999","cytochrome c [OS=Homo sapiens]",41,4,26,4,105,11.7,9.57,56.92,"other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus","other molecular function","CYCS","ENSG00000172115","Oxidative phosphorylation; Metabolic pathways; Platinum drug resistance; p53 signaling pathway; Apoptosis; Apoptosis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Legionellosis; Toxoplasmosis; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Colorectal cancer; Small cell lung cancer; Viral myocarditis; Lipid and atherosclerosis","Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Respiratory electron transport; TP53 Regulates Metabolic Genes; Detoxification of Reactive Oxygen Species; Formation of apoptosome; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity; Release of apoptotic factors from the mitochondria; Pyroptosis","miRNA regulation of DNA damage response; Alzheimer's disease and miRNA effects; AGE/RAGE pathway; Parkinson's disease pathway; Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; VEGFA-VEGFR2 signaling pathway; Oxidative damage response; NO/cGMP/PKG mediated neuroprotection; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Acute viral myocarditis; Nonalcoholic fatty liver disease; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Malignant pleural mesothelioma; Complement system in neuronal development and plasticity; Alzheimer's disease; DNA damage response",2521.1,2614.6,2671.7,2887.8,2643.8,1661.9,1.0853409327865433,0.11814830053080116,0.6162910529114594,0.21021413715231593,0.7320772478026746,0.13544309035637167,6153]
["Q00013-1","55 kDa erythrocyte membrane protein [OS=Homo sapiens]",25,11,13,11,466,52.3,7.37,29.49,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","kinase activity","MPP1","ENSG00000130830; ENSGGOG00000001049; ENSPPAG00000040588; ENSPTRG00000022450; ENSPTRG00000051407","","Sensory processing of sound by outer hair cells of the cochlea","MECP2 and associated Rett syndrome",1261.8,1289.8,1302.3,1307,1263,1872.7,0.8674679811826141,-0.20511758704264418,0.3747957400551151,0.4262053539664116,0.5679830114167191,0.24566465400432128,4823]
["Q00577","Transcriptional activator protein Pur-alpha [OS=Homo sapiens]",43,9,24,9,322,34.9,6.44,87.56,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","PURA","ENSG00000185129","","","Exercise-induced circadian regulation",3082.4,3136.1,3175.5,3082,3126.9,1980.6,1.1470785762256548,0.19796422103839048,0.34554678388342797,0.46149314479653264,0.5489244606398554,0.2604874161773559,4601]
["Q00653-1","Nuclear factor NF-kappa-B p100 subunit [OS=Homo sapiens]",34,22,60,21,900,96.7,6.25,196.7,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NFKB2","ENSG00000077150","MAPK signaling pathway; NF-kappa B signaling pathway; Osteoclast differentiation; C-type lectin receptor signaling pathway; Legionellosis; Human T-cell leukemia virus 1 infection; Epstein-Barr virus infection; Pathways in cancer; Viral carcinogenesis; Breast cancer","Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; PKMTs methylate histone lysines; RIP-mediated NFkB activation via ZBP1; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; Interleukin-1 processing; DEx/H-box helicases activate type I IFN and inflammatory cytokines production ; SUMOylation of immune response proteins","Regulation of toll-like receptor signaling pathway; Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Neural crest differentiation; Thymic stromal lymphopoietin (TSLP) signaling pathway; TNF-alpha signaling pathway; Ebstein-Barr virus LMP1 signaling; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Toll-like receptor signaling related to MyD88; ApoE and miR-146 in inflammation and atherosclerosis; Ebola virus pathway in host; Breast cancer pathway; Acute viral myocarditis; miRNAs involvement in the immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Interactions between immune cells and microRNAs in tumor microenvironment; Head and neck squamous cell carcinoma; IL-18 signaling pathway; FGF23 signaling in hypophosphatemic rickets and related disorders; Mitochondrial immune response to SARS-CoV-2; Neuroinflammation and glutamatergic signaling; Network map of SARS-CoV-2 signaling pathway; Inclusion body myositis; Sudden infant death syndrome (SIDS) susceptibility pathways",6835.5,6699.1,6594.3,8031,7792.6,7409.6,0.866385172942169,-0.20691954158313708,5.9495062809243205E-3,2.2255190726524114,0.07993555405749239,1.0972600104666186,544]
["Q00987-1","E3 ubiquitin-protein ligase Mdm2 [OS=Homo sapiens]",14,6,9,6,491,55.2,4.69,20.89,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","MDM2","ENSG00000135679","Endocrine resistance; Platinum drug resistance; FoxO signaling pathway; Cell cycle; p53 signaling pathway; Ubiquitin mediated proteolysis; Endocytosis; PI3K-Akt signaling pathway; Cellular senescence; C-type lectin receptor signaling pathway; Thyroid hormone signaling pathway; Shigellosis; Human cytomegalovirus infection; Human papillomavirus infection; Epstein-Barr virus infection; Pathways in cancer; Transcriptional misregulation in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Glioma; Prostate cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia","Ub-specific processing proteases; Oxidative Stress Induced Senescence; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of RUNX3 expression and activity; SUMOylation of ubiquitinylation proteins; SUMOylation of transcription factors; Regulation of TP53 Degradation; Regulation of TP53 Activity through Phosphorylation; Oncogene Induced Senescence; Regulation of TP53 Activity through Methylation; AKT phosphorylates targets in the cytosol; Stabilization of p53; Trafficking of AMPA receptors","Androgen receptor signaling pathway; miRNA regulation of DNA damage response; TP53 network; Cell cycle; Glioblastoma signaling pathways; Retinoblastoma gene in cancer; Apoptosis; Bladder cancer; Copper homeostasis; VEGFA-VEGFR2 signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of p53 pathway in prostate cancer; PI3K-Akt signaling pathway; Genotoxicity pathway; G1 to S cell cycle control; Male infertility; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; Malignant pleural mesothelioma; Senescence and autophagy in cancer; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)",701.8,682.9,737.3,530,545.9,1817.5,0.7333932397871017,-0.4473411271341749,0.5793836905502985,0.23703373419905158,0.7061389685229501,0.15110982115285795,5997]
["Q01167","Forkhead box protein K2 [OS=Homo sapiens]",8,5,12,4,660,69,9.54,25.47,"other metabolic processes;stress response;other biological processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","FOXK2","ENSG00000141568","","UCH proteinases","",504.9,507,526.7,582.5,557,677.6,0.846733806614936,-0.2400196037669502,0.06779598253772198,1.1687960408437512,0.257146256548111,0.5898197936152312,1927]
["Q01518-1","adenylyl cyclase-associated protein 1 [OS=Homo sapiens]",53,23,275,1,475,51.9,8.06,908.04,"cell organization and biogenesis;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","CAP1","ENSG00000131236","","Neutrophil degranulation; Platelet degranulation ; Role of ABL in ROBO-SLIT signaling","Angiopoietin-like protein 8 regulatory pathway; Insulin signaling; Complement system in neuronal development and plasticity",645.3,563.6,569,597.1,577.2,848.1,0.8791040348101266,-0.1858941881952427,0.421447453749764,0.37525656568716503,0.5937470006663502,0.22639857121523455,5188]
["Q01581","hydroxymethylglutaryl-CoA synthase, cytoplasmic [OS=Homo sapiens]",20,9,22,9,520,57.3,5.41,67.63,"other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","other molecular function","HMGCS1","ENSG00000112972","Valine, leucine and isoleucine degradation; Butanoate metabolism; Terpenoid backbone biosynthesis; Metabolic pathways; PPAR signaling pathway","PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Endochondral ossification; Endochondral ossification with skeletal dysplasias",2548.3,2580.4,2593.5,5696.1,5759.4,3125.9,0.5295924945478487,-0.917045418654857,0.05785951791251101,1.2376251892294892,0.23784882813416366,0.6236989839797111,1778]
["Q01974","Tyrosine-protein kinase transmembrane receptor ROR2 [OS=Homo sapiens]",3,3,3,3,943,104.7,6.55,6.43,"cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","ROR2","ENSG00000169071","Wnt signaling pathway","WNT5A-dependent internalization of FZD2, FZD5 and ROR2","Cardiac progenitor differentiation; Ectoderm differentiation; Wnt signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Malignant pleural mesothelioma",389.2,312,404.7,382,433.9,580.4,0.792021771825539,-0.3363880059044253,0.21612748595278997,0.6652899983247541,0.45146493136008625,0.3453759789236876,3499]
["Q02040-1","A-kinase anchor protein 17A [OS=Homo sapiens]",16,12,23,12,695,80.7,9.73,49.25,"RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus","other molecular function","AKAP17A","ENSG00000197976","","","",2484.6,2492.5,2488.7,2736.8,2832,2643.9,0.9090554872331874,-0.13755973807743235,0.010176647294118598,1.992395277155236,0.1059560043770838,0.9748744274010682,702]
["Q02241-1","Kinesin-like protein KIF23 [OS=Homo sapiens]",27,19,31,19,960,110,8.51,90.01,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KIF23","ENSG00000137807","MicroRNAs in cancer","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; MHC class II antigen presentation; Mitotic Telophase/Cytokinesis","Malignant pleural mesothelioma",2262.8,2310.9,2356.9,1867.2,1940.4,1736.3,1.2501307743646168,0.32207902101443914,2.1373248219421484E-3,2.6701294705092886,0.049435782036630266,1.3059585912437195,316]
["Q02383","Semenogelin-2 [OS=Homo sapiens]",1,1,2,1,582,65.4,9.07,4.54,"stress response;other biological processes","non-structural extracellular","other molecular function","SEMG2","ENSG00000124157","","","Genotoxicity pathway",376,384.8,386.2,377.9,362.2,513.4,0.9150378938970881,-0.1280966048181143,0.5014756578704854,0.29975014322003585,0.6487231121018368,0.18794062915550144,5650]
["Q02556","Interferon regulatory factor 8 [OS=Homo sapiens]",2,1,2,1,426,48.3,6.77,2.2,"other metabolic processes;stress response;transport;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","IRF8","ENSG00000140968","Pertussis","Interferon gamma signaling; Interferon alpha/beta signaling","Vitamin D receptor pathway; Development of pulmonary dendritic cells and macrophage subsets; Type II interferon signaling (IFNG)",58.6,70.7,66.4,80.7,51.5,4163.5,0.04555718509206882,-4.4561775818677125,0.3736382444923186,0.42754867708352523,0.5676412240686669,0.24592607210211642,4811]
["Q03001-7","dystonin [OS=Homo sapiens]",12,83,135,79,7570,860.1,5.25,375.37,"cell adhesion;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","DST","ENSG00000151914","","RND1 GTPase cycle; RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; Type I hemidesmosome assembly","",11498.8,11576.8,11696.5,13901.4,13249.9,12874.6,0.8687399908559207,-0.20300364400640128,0.004581996583387578,2.3389452389826046,0.07095299370334705,1.1490292757327192,472]
["Q03252","Lamin-B2 [OS=Homo sapiens]",64,48,309,41,620,69.9,5.59,891.24,"","other membranes;cytoskeleton;nucleus","other molecular function","LMNB2","ENSG00000176619","Apoptosis","","Gastric cancer network 2; Fas ligand pathway and stress induction of heat shock proteins; IL-18 signaling pathway; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome",35430,35021.4,34883,37355.7,34099.4,36810.3,0.9729276389317363,-0.03959558570461972,0.3924755956938098,0.4061873427022211,0.5773000863203976,0.23859837756378094,4969]
["Q03468","DNA excision repair protein ERCC-6 [OS=Homo sapiens]",3,4,4,4,1493,168.3,8.09,11.65,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","ERCC6","ENSG00000225830","Nucleotide excision repair","Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; B-WICH complex positively regulates rRNA expression; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression","Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum",406.1,337.5,356.1,445.7,415.7,379,0.886568848758465,-0.17369542326082205,0.1708409923400129,0.7674079146126912,0.4030590100107018,0.3946313661519054,3098]
["Q04656-1","copper-transporting ATPase 1 [OS=Homo sapiens]",8,8,15,8,1500,163.3,6.24,40.93,"","","","","","","","",1129.3,1126.6,1143,1178.6,1128.2,1399.4,0.9170848847876529,-0.12487281996073277,0.28686695129538403,0.5423194820669439,0.5102727055288299,0.29219766144484227,4109]
["Q04695","Keratin, type I cytoskeletal 17 [OS=Homo sapiens]",27,12,31,3,432,48.1,5.02,86.77,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","other molecular function","KRT17","ENSG00000128422","Estrogen signaling pathway; Staphylococcus aureus infection","Formation of the cornified envelope","",361.2,556.8,250.7,287.3,360.6,1769.8,0.48339330768912603,-1.0487305949542092,0.4439318243058407,0.3526837204285525,0.6083047813744638,0.2158787698984369,5334]
["Q05469-1","hormone-sensitive lipase [OS=Homo sapiens]",9,7,14,7,1076,116.5,6.7,42.9,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","LIPE","ENSG00000079435","cAMP signaling pathway; AMPK signaling pathway; Apelin signaling pathway; Thermogenesis; Insulin signaling pathway; Regulation of lipolysis in adipocytes; Aldosterone synthesis and secretion","Triglyceride catabolism","AMP-activated protein kinase (AMPK) signaling; Fatty acid beta-oxidation; Adipogenesis; Triacylglyceride synthesis; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Lipid metabolism pathway; Thermogenesis; Insulin signaling; Orexin receptor pathway; Familial partial lipodystrophy (FPLD)",697.8,721,673.7,682.7,678.1,921.7,0.9167579408543264,-0.12538723743387828,0.4809747796900835,0.3178776956190778,0.633527602226495,0.19823445854927066,5549]
["Q05519","serine/arginine-rich splicing factor 11 [OS=Homo sapiens]",18,10,38,10,484,53.5,10.52,76.07,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","SRSF11","ENSG00000116754","","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript","",4536.1,4512.8,4459.5,4569.3,4557.2,3760.7,1.0482028679620088,0.06791796141617777,0.48361469300482035,0.3155005130346299,0.6356302447711261,0.19679544622755726,5561]
["Q06124-2","Isoform 2 of Tyrosine-protein phosphatase non-receptor type 11 [OS=Homo sapiens]",39,21,47,21,593,68,7.3,127.47,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","PTPN11","ENSG00000179295; ENSMMUG00000013253; ENSRROG00000031729","Ras signaling pathway; Phospholipase D signaling pathway; Axon guidance; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; Leukocyte transendothelial migration; Neurotrophin signaling pathway; Adipocytokine signaling pathway; Insulin resistance; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Herpes simplex virus 1 infection; Proteoglycans in cancer; Chemical carcinogenesis; Renal cell carcinoma; Chronic myeloid leukemia; PD-L1 expression and PD-1 checkpoint pathway in cancer","PIP3 activates AKT signaling; GPVI-mediated activation cascade; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by SCF-KIT; RET signaling; Platelet sensitization by LDL; CTLA4 inhibitory signaling; FLT3 Signaling; Interleukin-3, Interleukin-5 and GM-CSF signaling; PD-1 signaling; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; Signal regulatory protein family interactions; PI3K Cascade; Downstream signal transduction; Tie2 Signaling; Interleukin-6 signaling; Signaling by Leptin; Regulation of IFNG signaling; Regulation of IFNA signaling; Signaling by CSF3 (G-CSF); GAB1 signalosome; PI-3K cascade:FGFR1; FRS-mediated FGFR1 signaling; PI-3K cascade:FGFR2; FRS-mediated FGFR2 signaling; FRS-mediated FGFR3 signaling; PI-3K cascade:FGFR3; FRS-mediated FGFR4 signaling; PI-3K cascade:FGFR4; Activated NTRK2 signals through FRS2 and FRS3; Spry regulation of FGF signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; Prolactin receptor signaling; Interleukin-20 family signaling; Netrin mediated repulsion signals; Interleukin-37 signaling; Signaling by FLT3 ITD and TKD mutants; PECAM1 interactions; MET activates PTPN11; STAT5 activation downstream of FLT3 ITD mutants; Regulation of RUNX1 Expression and Activity; STAT5 Activation","IL-5 signaling pathway; Heart development; IL-1 signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Pilocytic astrocytoma; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL-6 signaling pathway; Hepatitis C and hepatocellular carcinoma; VEGFA-VEGFR2 signaling pathway; Embryonic stem cell pluripotency pathways; IL-4 signaling pathway; Ras signaling; EGF/EGFR signaling pathway; Fragile X syndrome; Cancer immunotherapy by CTLA4 blockade; Cancer immunotherapy by PD-1 blockade; Gastrin signaling pathway; Netrin-UNC5B signaling pathway; Insulin signaling; IL-2 signaling pathway; Angiotensin II receptor type 1 pathway; Kallmann syndrome; Interferon type I signaling pathways; Type II interferon signaling (IFNG); T-cell receptor (TCR) signaling pathway",6004.2,6012.2,6158.9,5829.4,5349.3,5228,{"$f":"AVERAGE(S2626:U2626)/AVERAGE(V2626:X2626)","v":1.1077974242230306},{"$f":"LOG(Y2626,2)","v":0.14769408915911394},{"$f":"TTEST(V2626:X2626,S2626:U2626,2,2)","v":0.03634083989665372},1.4396050396513493,{"$f":"AA2626*7309/AE2626","v":0.18692132217075447},0.7283411556948461,1421]
["Q06481","Amyloid-like protein 2 [OS=Homo sapiens]",4,4,4,4,763,86.9,4.79,8.09,"signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","APLP2","ENSG00000084234","","Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","Splicing factor NOVA regulated synaptic proteins",581.1,573.3,590.9,455,450.7,610.3,1.1512532981530346,0.20320528940865107,0.22089033525618088,0.6558232856529325,0.4541455584774757,0.3428049288347446,3555]
["Q07020","60S ribosomal protein L18 [OS=Homo sapiens]",46,8,48,8,188,21.6,11.72,150.29,"protein metabolism;other metabolic processes","cytosol;ER/Golgi;translational apparatus;nucleus","nucleic acid binding activity;other molecular function","RPL18","ENSG00000063177","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis","Cytoplasmic ribosomal proteins",6083.6,6268.9,5817.4,6706,7625.6,6459.6,0.8739226211089307,-0.19442254866769762,0.08201671750119341,1.0860976161707665,0.2846439640153004,0.5456980211362612,2106]
["Q07157","Tight junction protein ZO-1 [OS=Homo sapiens]",18,28,46,26,1748,195.3,6.7,137.15,"cell adhesion;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","TJP1","ENSG00000104067; ENSG00000277401","Adherens junction; Tight junction; Gap junction; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection","RUNX1 regulates expression of components of tight junctions; Signaling by Hippo; Apoptotic cleavage of cell adhesion  proteins; Regulation of gap junction activity","Epithelial to mesenchymal transition in colorectal cancer; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; Disruption of postsynaptic signaling by CNV; 1q21.1 copy number variation syndrome",4175.1,4151.1,4094.8,5215.9,4976.2,7524.5,0.7010938893467143,-0.5123204343538553,0.09561785304838576,1.0194610119444212,0.3070610228166307,0.5127753077834817,2276]
["Q07866-6","Isoform N of Kinesin light chain 1 [OS=Homo sapiens]",38,25,77,21,628,71,6.67,227.5,"","","","KLC1","","","","",9374.7,9370,9378.8,9975.5,10145.3,6531.6,1.055195779742162,0.07751069965165025,0.6984085297319143,0.15589046518896837,0.7949957862966144,0.09963517322149006,6421]
["Q07889","Son of sevenless homolog 1 [OS=Homo sapiens]",7,8,10,8,1333,152.4,6.84,23.92,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","SOS1","ENSG00000115904","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Chemokine signaling pathway; FoxO signaling pathway; Phospholipase D signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Focal adhesion; Gap junction; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Thermogenesis; Neurotrophin signaling pathway; Regulation of actin cytoskeleton; Insulin signaling pathway; GnRH signaling pathway; Estrogen signaling pathway; Prolactin signaling pathway; Relaxin signaling pathway; Growth hormone synthesis, secretion and action; Alcoholism; Hepatitis C; Hepatitis B; Human cytomegalovirus infection; Human papillomavirus infection; Pathways in cancer; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Endometrial cancer; Glioma; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Choline metabolism in cancer","RAC1 GTPase cycle; Role of LAT2/NTAL/LAB on calcium mobilization; RET signaling; FLT3 Signaling; Downstream signal transduction; Tie2 Signaling; FRS-mediated FGFR1 signaling; FRS-mediated FGFR2 signaling; FRS-mediated FGFR3 signaling; FRS-mediated FGFR4 signaling; Activated NTRK2 signals through FRS2 and FRS3; Signaling by FLT3 ITD and TKD mutants; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; NRAGE signals death through JNK; G alpha (12/13) signalling events; Interleukin receptor SHC signaling; RAF/MAP kinase cascade; DAP12 signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; Regulation of KIT signaling; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; GRB2 events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; GRB2 events in EGFR signaling; SHC1 events in EGFR signaling; NCAM signaling for neurite out-growth; Signaling by FGFR1 in disease; SHC-mediated cascade:FGFR1; SHC-mediated cascade:FGFR2; Signaling by FGFR2 in disease; SHC-mediated cascade:FGFR3; SHC-mediated cascade:FGFR4; Signaling by FGFR3 point mutants in cancer; Activation of RAC1; Erythropoietin activates RAS; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; SOS-mediated signalling; Signalling to RAS; SHC-related events triggered by IGF1R; Signaling by FGFR4 in disease; MET activates RAS signaling; Signaling by FGFR3 fusions in cancer; Activated NTRK2 signals through RAS; Activated NTRK3 signals through RAS; Constitutive Signaling by Overexpressed ERBB2; Signaling by FLT3 fusion proteins; Signal attenuation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Interleukin-15 signaling","IL-5 signaling pathway; Integrin-mediated cell adhesion; Leptin signaling pathway; Prolactin signaling pathway; Pilocytic astrocytoma; B cell receptor signaling pathway; TNF-alpha signaling pathway; Oncostatin M signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL-6 signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Acute viral myocarditis; Thermogenesis; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Malignant pleural mesothelioma; Regulation of actin cytoskeleton; EPO receptor signaling; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent)",762.9,786,797.6,809.9,795.5,843.6,0.9581461821151489,-0.06168231353571519,0.12303064190786454,0.9099867100714011,0.34853913244363643,0.4577484541506583,2580]
["Q08378","Golgin subfamily A member 3 [OS=Homo sapiens]",27,31,49,31,1498,167.3,5.44,179.93,"other biological processes","other membranes;cytosol;ER/Golgi;nucleus","","GOLGA3","ENSG00000090615","","RND2 GTPase cycle","",3837.9,3846.2,4066.1,4138.6,4304.2,5305.8,0.8546470186055309,-0.22659940548001975,0.14799233137558634,0.8297607881695904,0.37900348634343395,0.42135679506424567,2854]
["Q08752","peptidyl-prolyl cis-trans isomerase D [OS=Homo sapiens]",59,23,87,22,370,40.7,7.21,264.19,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","PPID","ENSG00000171497","Necroptosis; Cellular senescence; Alzheimer disease; Pathways of neurodegeneration; Shigellosis","ESR-mediated signaling","Alzheimer's disease and miRNA effects; NO/cGMP/PKG mediated neuroprotection; Alzheimer's disease",11562,11464.8,11680.5,12414,12837.2,11379.6,0.9474895443178963,-0.07781807186109874,0.2165621151564672,0.6644175154740846,0.45198529402587634,0.34487569533753887,3502]
["Q08AD1","Calmodulin-regulated spectrin-associated protein 2 [OS=Homo sapiens]",8,9,11,9,1489,168,6.8,30.42,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi","cytoskeletal activity;other molecular function","CAMSAP2","ENSG00000118200","","","",924,877.7,826.8,1041.6,1035.4,2342.4,0.5947639951124587,-0.7496107804575656,0.24237099251783492,0.6155193586941731,0.4722712834745016,0.32580846096092286,3751]
["Q09327","Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase [OS=Homo sapiens]",8,3,3,3,533,61.3,8.28,8.11,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi","other molecular function","MGAT3","ENSG00000128268","N-Glycan biosynthesis; Metabolic pathways","Reactions specific to the hybrid N-glycan synthesis pathway","",135.5,136,149.2,235.5,286.9,183.4,0.5960612071408331,-0.7464676120109346,0.034665375283853314,1.460104093811541,0.18346794203452851,0.7364398105061993,1381]
["Q0P6H9","Transmembrane protein 62 [OS=Homo sapiens]",11,5,7,5,643,73.1,9.26,26.35,"","other membranes","other molecular function","TMEM62","ENSG00000137842","","","",456.4,453.7,442.1,481.6,412.6,618.7,{"$f":"AVERAGE(S2690:U2690)/AVERAGE(V2690:X2690)","v":0.8937801573137681},{"$f":"LOG(Y2690,2)","v":-0.16200807886644833},{"$f":"TTEST(V2690:X2690,S2690:U2690,2,2)","v":0.42755145463285427},0.36901161165301194,{"$f":"AA2690*7309/AE2690","v":0.5976235574510483},0.22357229159869457,5229]
["Q0VDG4-1","secernin-3 [OS=Homo sapiens]",26,9,16,9,424,48.5,5.55,46.04,"protein metabolism","","other molecular function","SCRN3","ENSG00000144306","","","",1450,1555.5,1491.7,1498.9,1465.6,1103.5,1.1055063913470993,0.1447073659394037,0.33379788287160495,0.47651642218072443,0.5430066160490898,0.2651948788897769,4493]
["Q11201","CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 [OS=Homo sapiens]",15,4,7,4,340,39.1,9.09,28.5,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","ST3GAL1","ENSG00000008513","Mucin type O-glycan biosynthesis; Glycosaminoglycan biosynthesis; Glycosphingolipid biosynthesis; Glycosphingolipid biosynthesis; Metabolic pathways","Maturation of spike protein; Sialic acid metabolism; Keratan sulfate biosynthesis; Maturation of protein 3a; Maturation of protein 3a; Termination of O-glycan biosynthesis","Ganglio sphingolipid metabolism; Globo sphingolipid metabolism",616.7,561.9,583.1,760,842.4,894.8,0.7054701265417266,-0.5033431023590835,0.004426143518167934,2.3539745081363113,0.06972129951355481,1.1566345268072193,464]
["Q12765","Secernin-1 [OS=Homo sapiens]",3,1,1,1,414,46.4,4.75,2.14,"protein metabolism;transport","other membranes;nucleus;other cell component","other molecular function","SCRN1","ENSG00000136193","","","",27.2,42.7,38,49.1,27.6,96.7,0.6222606689734718,-0.684409033733818,0.3556772918741109,0.44894386134944647,0.555717256585694,0.2551461169386077,4678]
["Q12792-2","Twinfilin-1 [OS=Homo sapiens]",40,12,33,9,350,40.3,6.96,94.03,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","TWF1","ENSG00000151239","","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHOBTB2 GTPase cycle","",2044.5,1988.7,2021.9,2219.2,2014.8,2623.6,0.8829765515632291,-0.17955296889654845,0.21063943178724756,0.6764603254363396,0.44702776043350534,0.3496655063339838,3444]
["Q12824-1","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 [OS=Homo sapiens]",37,10,52,10,385,44.1,6.23,155.01,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","LOC101347788; LOC111142756; Smarcb1; SMARCB1","ENSCAFG00000014105; ENSCATG00000029590; ENSCCAG00000036123; ENSCHIG00000019816; ENSCSAG00000011285; ENSDLEG00000015913; ENSECAG00000007797; ENSG00000099956; ENSG00000275837; ENSHGLG00000019077; ENSMFAG00000040790; ENSMLUG00000004975; ENSMMUG00000009098; ENSMNEG00000033936; ENSMUSG00000000902; ENSPANG00000026464; ENSPPAG00000028391; ENSRBIG00000027964; ENSRFEG00010017090; ENSRROG00000030710; ENSSBOG00000031674; ENSSSCG00000010070; ENSSSCG00070020965; ENSSSUG00005014167; ENSSTOG00000012408; ENSTSYG00000008262; ENSUAMG00000010813","Thermogenesis; Hepatocellular carcinoma","RMTs methylate histone arginines; RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines","TNF-alpha NF-kB signaling pathway; Tumor suppressor activity of SMARCB1; Thermogenesis; Modulators of TCR signaling and T cell activation",2614,2763.3,2746.7,2911.4,2810.9,2680.2,0.9668551026480213,-0.04862839789921136,0.3204671988447231,0.49421641572316066,0.5356265164317587,0.2711379311840447,4373]
["Q12851","Mitogen-activated protein kinase kinase kinase kinase 2 [OS=Homo sapiens]",13,8,11,8,820,91.5,6.34,30,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi","kinase activity;other molecular function","MAP4K2","ENSG00000168067","MAPK signaling pathway","","TNF-alpha signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Insulin signaling; Malignant pleural mesothelioma",655.7,565.8,566.3,629.5,640.7,731.2,0.8932747077046067,-0.16282418102232044,0.18036560216739206,0.7438462839409812,0.41377658074120166,0.38323409352212096,3186]
["Q12893","Transmembrane protein 115 [OS=Homo sapiens]",15,4,8,4,351,38.2,8.16,28.67,"transport;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","TMEM115","ENSG00000126062","","COPI-mediated anterograde transport","",386.9,379.2,440.8,405.9,346.6,449.4,1.0041600798735333,0.005989277287047632,0.9648444607090023,0.015542692148692446,0.9797232791500553,0.008896572581611894,7198]
["Q12907","Vesicular integral-membrane protein VIP36 [OS=Homo sapiens]",42,13,93,13,356,40.2,6.95,303.48,"cell organization and biogenesis;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","LMAN2","ENSG00000169223","Protein processing in endoplasmic reticulum","COPII-mediated vesicle transport; Cargo concentration in the ER","",13612.2,14059.8,14358,12068.5,12275,12963.1,1.1266103048790295,0.1719885727933127,0.010472581082627315,1.979946268483926,0.10660737483694017,0.9722127508422532,718]
["Q12931","heat shock protein 75 kDa, mitochondrial [OS=Homo sapiens]",50,30,194,29,704,80.1,8.21,663.74,"other biological processes","other membranes;mitochondrion;nucleus","signal transduction activity or receptor binding;other molecular function","TRAP1","ENSG00000126602","Parkinson disease; Pathways of neurodegeneration","Respiratory electron transport","TNF-alpha signaling pathway; TGF-beta signaling pathway",17022.8,17019.6,17013.2,15818.5,15338.3,15506.9,1.094118126080872,0.1297685066049482,4.8164862319587256E-4,3.3172696768172223,0.023313707198269088,1.6323886622264185,151]
["Q12979","active breakpoint cluster region-related protein [OS=Homo sapiens]",17,15,38,15,859,97.5,6.55,106.76,"signal transduction;other biological processes","cytosol;other cell component","enzyme regulator activity","ABR","ENSG00000159842; ENSG00000276016; ENSG00000278741","","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC3 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOC GTPase cycle; RAC2 GTPase cycle; RHOB GTPase cycle","",4845.7,4944,4878.9,4838.1,4608.3,3004.6,1.178106176210746,0.23646956717335418,0.26967978027616224,0.5691516143319716,0.49637106875811376,0.3041935395118816,3971]
["Q12982","BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 [OS=Homo sapiens]",13,5,6,5,314,36,4.81,16.43,"other metabolic processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","BNIP2","ENSG00000140299","","Myogenesis","Acute viral myocarditis",795.8,869.1,814.6,896.2,992.8,623.9,0.9867085837080664,-0.01930403545149561,0.9260016029791157,0.0333882615206769,0.9543352673680706,0.020299026565584122,7092]
["Q13033-2","Isoform Alpha of Striatin-3 [OS=Homo sapiens]",11,6,9,1,713,77.7,5.26,23.04,"","","","STRN3","","","","",33.2,29.1,27.3,29.7,41.2,39.5,0.8115942028985508,-0.30116953472056485,0.1569734309305862,0.8041738493531865,0.3889216293802219,0.4101379034473765,2950]
["Q13085-1","Acetyl-CoA carboxylase 1 [OS=Homo sapiens]",18,34,70,29,2346,265.4,6.37,209.21,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","ACACA","ENSG00000275176; ENSG00000278540","Fatty acid biosynthesis; Pyruvate metabolism; Propanoate metabolism; Metabolic pathways; Fatty acid metabolism; AMPK signaling pathway; Insulin signaling pathway; Glucagon signaling pathway; Alcoholic liver disease","Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency; ChREBP activates metabolic gene expression; Carnitine metabolism; Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis","AMP-activated protein kinase (AMPK) signaling; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; Corticotropin-releasing hormone signaling pathway; Mesodermal commitment pathway; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin and adiponectin; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Mitochondrial fatty acid synthesis pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; 7q11.23 copy number variation syndrome",6410,6607.2,6520.7,6580.9,6338.7,7368.5,0.9630226586028264,-0.05435835178294847,0.473098087554666,0.32504880753404775,0.627905197373716,0.2021059221313573,5507]
["Q13107-1","Ubiquitin carboxyl-terminal hydrolase 4 [OS=Homo sapiens]",25,18,30,17,963,108.5,5.71,84.23,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","USP4","ENSG00000114316","","Ub-specific processing proteases; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; TNFR1-induced proapoptotic signaling","",2317,2415.7,2305,2510.5,2349.7,2009,1.024529785127817,0.034961926986117595,0.7303819854702609,0.13644994701173915,0.8165129904867141,0.0880369013721164,6538]
["Q13144","Translation initiation factor eIF-2B subunit epsilon [OS=Homo sapiens]",25,14,54,14,721,80.3,5.08,172.66,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;translational apparatus;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","EIF2B5","ENSG00000145191","Herpes simplex virus 1 infection","Recycling of eIF2:GDP","Translation factors; MicroRNAs in cardiomyocyte hypertrophy",4877,4874.7,5019.8,4725.6,4582.1,6262.7,0.9486911062015103,-0.07598967264991602,0.6477652386445042,0.18858236146622173,0.7552266915381529,0.12192266942120769,6269]
["Q13164-1","Mitogen-activated protein kinase 7 [OS=Homo sapiens]",8,4,10,4,816,88.3,5.88,27.2,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","MAPK7","ENSG00000166484","MAPK signaling pathway; Gap junction; IL-17 signaling pathway; Neurotrophin signaling pathway; GnRH signaling pathway; Oxytocin signaling pathway; MicroRNAs in cancer; Fluid shear stress and atherosclerosis","Senescence-Associated Secretory Phenotype (SASP); Gastrin-CREB signalling pathway via PKC and MAPK; ERKs are inactivated; RET signaling; Signalling to ERK5","MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Brain-derived neurotrophic factor (BDNF) signaling pathway; S1P receptor signal transduction; Cardiac hypertrophic response; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Osteoblast differentiation and related diseases; Insulin signaling; Malignant pleural mesothelioma",252.3,246.6,226.2,256.1,273.9,513.5,0.6948730234786774,-0.5251787215604589,0.27195915100863877,0.565496323259211,0.4986827482995837,0.3021756557397068,3986]
["Q13188","serine/threonine-protein kinase 3 [OS=Homo sapiens]",22,10,38,6,491,56.3,5.24,113.73,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","STK3","ENSG00000104375","MAPK signaling pathway; Hippo signaling pathway; Hippo signaling pathway","Signaling by Hippo","MAPK signaling pathway; Transcription co-factors SKI and SKIL protein partners; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Overview of leukocyte-intrinsic Hippo pathway functions; Malignant pleural mesothelioma",999.7,997.7,1053.4,957.6,1044.5,679.1,1.1378487244517381,0.18630876591311857,0.3319762857383611,0.4788929384068366,0.5419733465404694,0.2660220709063087,4477]
["Q13232","Nucleoside diphosphate kinase 3 [OS=Homo sapiens]",37,6,24,6,169,19,7.84,62.61,"other metabolic processes;other biological processes","cytosol","kinase activity;other molecular function","NME3","ENSG00000103024","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors","Interconversion of nucleotide di- and triphosphates","Pyrimidine metabolism",3303.7,3267.2,3390.9,3073,3146.3,3209.7,1.0565065224307986,0.07930167389805112,0.030095078602169874,1.5215045180496394,0.17198196208229838,0.7645171006443203,1279]
["Q13243-1","Serine/arginine-rich splicing factor 5 [OS=Homo sapiens]",30,9,51,8,272,31.2,11.59,160.37,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","SFRS5; SRSF5","ENSCANG00000030560; ENSCCAG00000029002; ENSCJAG00000014884; ENSCSAG00000013041; ENSG00000100650; ENSGGOG00000016462; ENSMFAG00000002393; ENSMMUG00000022407; ENSMNEG00000030872; ENSNLEG00000001615; ENSPPAG00000029921; ENSPPYG00000005945; ENSPTRG00000006488; ENSRBIG00000013003; ENSRROG00000043407; ENSSBOG00000030784","Spliceosome; Herpes simplex virus 1 infection","mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","mRNA processing; mRNA Processing",5719.9,5783.6,5490.4,5863.6,6091,6165.1,0.9378687285109577,-0.09254208896922814,0.04186782881774655,1.3781195601720788,0.20119129574550265,0.6963908123411042,1521]
["Q13303-2","Isoform 2 of Voltage-gated potassium channel subunit beta-2 [OS=Homo sapiens]",48,13,60,13,353,39.3,8.62,152.58,"","","","KCNAB2","","","","",6200.9,6359.9,6523,5938.5,5925.7,5065.1,1.1272645649849666,0.17282615064594314,0.0772067917905231,1.1123444936098006,0.2756738843170168,0.5596043743883332,2047]
["Q13325","Interferon-induced protein with tetratricopeptide repeats 5 [OS=Homo sapiens]",21,9,16,9,482,55.8,7.4,47.35,"stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity","IFIT5","ENSG00000152778","","Interferon alpha/beta signaling","",1356.8,1408.1,1436.6,1588.6,1413.3,981.1,1.0548581471252825,0.07704900443147655,0.7095099542870149,0.14904150709643582,0.801268271922712,0.09622205381667874,6472]
["Q13395","Probable methyltransferase TARBP1 [OS=Homo sapiens]",2,3,3,3,1621,181.6,7.05,7.9,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","TARBP1","ENSG00000059588","","","",268.5,280.7,297,285.2,281.5,464.3,0.820756547041707,-0.28497374189912056,0.36891263873227537,0.4330764658421568,0.5650424301119448,0.24791893895648814,4772]
["Q13423","NAD(P) transhydrogenase, mitochondrial [OS=Homo sapiens]",42,39,277,39,1086,113.8,8.09,854.59,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","NNT","ENSG00000112992","Nicotinate and nicotinamide metabolism; Metabolic pathways","Citric acid cycle (TCA cycle)","",41669.5,41608.6,42416.1,34477,35727.9,32138,1.2281672690533494,0.2965070605451962,1.9896326846114945E-3,2.701227093324257,0.04736881202548995,1.3245075069174705,307]
["Q13433-1","Zinc transporter ZIP6 [OS=Homo sapiens]",3,2,3,2,755,85,6.95,8.51,"transport;other biological processes","plasma membrane;other membranes;ER/Golgi","transporter activity","SLC39A6","ENSG00000141424","Alzheimer disease; Parkinson disease","Zinc influx into cells by the SLC39 gene family","Nuclear receptors meta-pathway; NRF2 pathway; Zinc homeostasis",494,489.5,479.9,508.5,501.1,549.7,0.9384980439940998,-0.09157435667506245,0.11110474017434185,0.9542674119174172,0.3311845619634032,0.47992991587982164,2452]
["Q13439-1","Golgin subfamily A member 4 [OS=Homo sapiens]",23,44,60,42,2230,261,5.39,181.85,"cell organization and biogenesis;transport;developmental processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","GOLGA4","ENSG00000144674","","Retrograde transport at the Trans-Golgi-Network; Signaling by membrane-tethered fusions of PDGFRA or PDGFRB","",4372.9,4383.3,4339.4,5062.7,4901,5392,0.8528168693058603,-0.2296921190050925,0.00654723462119412,2.183942095787303,0.0830794059831733,1.080506617326542,576]
["Q13464","Rho-associated protein kinase 1 [OS=Homo sapiens]",36,47,75,41,1354,158.1,5.9,189.39,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function","ROCK1","ENSG00000067900","cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Vascular smooth muscle contraction; TGF-beta signaling pathway; Axon guidance; Focal adhesion; Tight junction; Platelet activation; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Pathogenic Escherichia coli infection; Shigellosis; Yersinia infection; Human cytomegalovirus infection; Pathways in cancer; Proteoglycans in cancer; MicroRNAs in cancer","Neutrophil degranulation; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHOB GTPase cycle; Sema4D induced cell migration and growth-cone collapse; RND3 GTPase cycle; RHOBTB1 GTPase cycle; EPHB-mediated forward signaling; Potential therapeutics for SARS; VEGFA-VEGFR2 Pathway; Apoptotic cleavage of cellular proteins; EPHA-mediated growth cone collapse; RHO GTPases Activate ROCKs; RHOH GTPase cycle","Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Microtubule cytoskeleton regulation; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Focal adhesion; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; EGF/EGFR signaling pathway; Gastrin signaling pathway; mBDNF and proBDNF regulation of GABA neurotransmission; MAP3K1 role in promoting and blocking gonadal determination; Airway smooth muscle cell contraction; RAS and bradykinin pathways in COVID-19; Regulation of actin cytoskeleton; G13 signaling pathway",8346.7,8210.9,8140,8906.5,8483,7989,0.9731702031246922,-0.039235946890450873,0.4509197004138632,0.34590079021099257,0.6120282433286771,0.21322853596101995,5385]
["Q13480-1","GRB2-associated-binding protein 1 [OS=Homo sapiens]",26,13,23,13,694,76.6,5.96,75.05,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;other cell component","","GAB1","ENSG00000109458","EGFR tyrosine kinase inhibitor resistance; ErbB signaling pathway; Ras signaling pathway; Phospholipase D signaling pathway; Neurotrophin signaling pathway; Bacterial invasion of epithelial cells; Proteoglycans in cancer; Renal cell carcinoma; Hepatocellular carcinoma; Gastric cancer","Signaling by ERBB2 KD Mutants; Signaling by FGFR1 in disease; Signaling by FGFR2 in disease; Signaling by FGFR3 point mutants in cancer; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FGFR4 in disease; Signaling by FGFR3 fusions in cancer; RET signaling; PIP3 activates AKT signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Constitutive Signaling by Aberrant PI3K in Cancer; MET activates RAP1 and RAC1; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); PI3K Cascade; PI3K events in ERBB2 signaling; GAB1 signalosome; PI-3K cascade:FGFR1; PI-3K cascade:FGFR2; PI-3K cascade:FGFR3; PI-3K cascade:FGFR4; MET activates PI3K/AKT signaling; MET activates PTPN11; MET receptor recycling; Activated NTRK2 signals through PI3K","Glioblastoma signaling pathways; B cell receptor signaling pathway; Alpha 6 beta 4 signaling pathway; Hepatocyte growth factor receptor signaling; IL-6 signaling pathway; BDNF-TrkB signaling; VEGFA-VEGFR2 signaling pathway; Embryonic stem cell pluripotency pathways; Ras signaling; EGF/EGFR signaling pathway; Fragile X syndrome; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; ErbB signaling pathway",2186,2161.5,1958.2,2221.9,2218,2830.7,0.8672874315737353,-0.2054178922319395,0.21072594345731582,0.6762819930736628,0.44708154447881604,0.3496132574333344,3445]
["Q13510","Acid ceramidase [OS=Homo sapiens]",39,14,67,14,395,44.6,7.62,179.54,"other metabolic processes;developmental processes;other biological processes","non-structural extracellular;nucleus;other cytoplasmic organelle;other cell component","other molecular function","ASAH1","ENSG00000104763","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway; Lysosome","Neutrophil degranulation; Glycosphingolipid metabolism","Sphingolipid pathway; S1P receptor signal transduction; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway; Sphingolipid metabolism in senescence",7359.1,7185.2,7360.1,6810.9,7121.3,6359.6,1.0794705250396712,0.11032385108654864,0.0784364823798415,1.10548189125718,0.27762336547906125,0.556543985365627,2065]
["Q13555-8","Isoform 8 of Calcium/calmodulin-dependent protein kinase type II subunit gamma [OS=Homo sapiens]",27,11,24,9,556,62.1,7.42,70.38,"protein metabolism;other metabolic processes;other biological processes","other cell component","kinase activity;other molecular function","CAMK2G; LOC111145432","ENSCATG00000041481; ENSECAG00000000031; ENSFCAG00000018407; ENSG00000148660; ENSLCNG00005022562; ENSMPUG00000003376; ENSPANG00000022457; ENSPTRG00000002643","ErbB signaling pathway; Calcium signaling pathway; cAMP signaling pathway; HIF-1 signaling pathway; Oocyte meiosis; Necroptosis; Adrenergic signaling in cardiomyocytes; Wnt signaling pathway; Axon guidance; Circadian entrainment; Long-term potentiation; Neurotrophin signaling pathway; Cholinergic synapse; Dopaminergic synapse; Olfactory transduction; Inflammatory mediator regulation of TRP channels; Insulin secretion; GnRH signaling pathway; Melanogenesis; Oxytocin signaling pathway; Glucagon signaling pathway; Aldosterone synthesis and secretion; Cushing syndrome; Gastric acid secretion; Parkinson disease; Pathways of neurodegeneration; Amphetamine addiction; Tuberculosis; Pathways in cancer; Proteoglycans in cancer; Glioma; Diabetic cardiomyopathy; Lipid and atherosclerosis","","Energy metabolism; Myometrial relaxation and contraction pathways; NO/cGMP/PKG mediated neuroprotection; Splicing factor NOVA regulated synaptic proteins; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Disruption of postsynaptic signaling by CNV; Neuroinflammation and glutamatergic signaling; Calcium regulation in cardiac cells; ErbB signaling pathway; Calcium regulation in cardiac cells",2113.4,2174.3,2158.8,1871.5,1771.1,1723.9,1.2012484859778256,0.2645346126650742,1.5869636957132837E-3,2.7994330082998045,0.042959695007290334,1.3669388105748186,270]
["Q13564-1","NEDD8-activating enzyme E1 regulatory subunit [OS=Homo sapiens]",54,17,64,17,534,60.2,5.4,215.51,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","NAE1","ENSG00000159593","Alzheimer disease","Neddylation","Alzheimer's disease and miRNA effects; Hijack of ubiquitination by SARS-CoV-2; Alzheimer's disease",5571.3,5730.5,5682,5694.2,5645.9,6678.4,0.9425756861003968,-0.08531962761726465,0.3673648054218433,0.4349024526661029,0.5634982923039354,0.24910739575647517,4765]
["Q13576-1","Ras GTPase-activating-like protein IQGAP2 [OS=Homo sapiens]",47,62,224,61,1575,180.5,5.64,738.75,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","IQGAP2","ENSG00000145703","Regulation of actin cytoskeleton","CDC42 GTPase cycle; RAC1 GTPase cycle; Neutrophil degranulation; RHOG GTPase cycle; RHO GTPases activate IQGAPs","Ciliary landscape; G13 signaling pathway",24017.2,24129.4,24611.7,21279.9,21419.5,18646.7,1.186029755762795,0.24614020545972692,0.01444486723129086,1.8402864455804446,0.12247973850754627,0.9119357495211845,862]
["Q13614-1","Myotubularin-related protein 2 [OS=Homo sapiens]",8,3,3,3,643,73.3,7.4,11.38,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MTMR2","ENSG00000087053; ENSGGOG00000010339; ENSPPAG00000042525; ENSPTRG00000004195","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; Synthesis of PIPs at the ER membrane","Intracellular trafficking proteins involved in CMT neuropathy",81.2,93.2,86.2,86.8,87,158,0.78541289933695,-0.3484768023877286,0.37787805473018266,0.4226483290047325,0.5688796502621843,0.24497960136478322,4855]
["Q13617-1","Cullin-2 [OS=Homo sapiens]",37,25,81,25,745,86.9,6.92,223.45,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction","cytosol;nucleus;other cell component","other molecular function","CUL2","ENSCANG00000032700; ENSCATG00000031722; ENSCCAG00000022671; ENSG00000108094; ENSMFAG00000044478; ENSMMUG00000002469; ENSMNEG00000040111; ENSPANG00000022742; ENSPPYG00000019905","HIF-1 signaling pathway; Ubiquitin mediated proteolysis; Pathways in cancer; Renal cell carcinoma","Antigen processing: Ubiquitination & Proteasome degradation; Regulation of expression of SLITs and ROBOs; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Neddylation","Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2",9070.7,9414.1,9384.2,9142.9,8258.9,7409.4,1.1232427290900886,0.1676697231214247,0.11753705894161932,0.9298251805724956,0.34117488634006976,0.4670229444603664,2518]
["Q13636","ras-related protein rab-31 [OS=Homo sapiens]",8,1,1,1,194,21.6,7.06,4.1,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","RAB31","ENSG00000168461","Endocytosis","Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation","",25.8,19.5,24.5,22.4,22.6,33.1,0.8937259923175417,-0.162095511932327,0.5293284445308061,0.27627476769237347,0.6699327447750063,0.17396879437258245,5775]
["Q13642-1","Isoform 1 of Four and a half LIM domains protein 1 [OS=Homo sapiens]",58,14,55,14,280,31.9,8.32,169.98,"","","","FHL1","","","","",11279.7,11075.5,11006.2,10559.4,10081.4,9983.4,1.089380294015844,0.1235076753727354,0.009616912369907167,2.0169643412627423,0.10351990060626139,0.984976153659271,679]
["Q13813","Spectrin alpha chain, non-erythrocytic 1 [OS=Homo sapiens]",71,168,1089,1,2472,284.4,5.35,3590.42,"cell organization and biogenesis","non-structural extracellular;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SPTAN1","ENSG00000197694","Apoptosis","Neutrophil degranulation; COPI-mediated anterograde transport; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Interaction between L1 and Ankyrins; RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Caspase-mediated cleavage of cytoskeletal proteins","Fas ligand pathway and stress induction of heat shock proteins",906.4,786,880.9,902.9,931,549.1,1.079857322702476,0.11084070736338293,0.6467568697019175,0.1892589496113569,0.7545324757623806,0.12232206305755279,6265]
["Q13868","Exosome complex component Rrp4 [OS=Homo sapiens]",25,6,17,6,293,32.8,7.5,62.26,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","EXOSC2","ENSG00000130713","RNA degradation","ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; Major pathway of rRNA processing in the nucleolus and cytosol; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease","Ciliary landscape",1240.3,1363.5,1382.9,1268,1095.9,764.6,1.2743167652229506,0.3497239422821103,0.13740062809992157,0.8620112819802054,0.36359927254972,0.43937699433884486,2762]
["Q13948","Protein CASP [OS=Homo sapiens]",35,22,48,5,678,77.4,5.44,118.09,"transport","other membranes;ER/Golgi;nucleus","","CUX1","ENSG00000257923","","Intra-Golgi traffic","",467.9,458.1,465.9,496.7,533.6,349.8,1.0085501050648504,0.012282759243834679,0.9475774010152251,0.023385305411723845,0.9685139454650091,0.013894121568620492,7151]
["Q13951-2","Isoform 2 of Core-binding factor subunit beta [OS=Homo sapiens]",29,5,16,5,187,22,5.58,50.61,"","","","CBFB","","","","",1323.7,1368.2,1358.6,1534.1,1666.9,1018.2,0.9600161167993934,-0.058869468812543554,0.7908179657544975,0.10192347297063989,0.8602602339186817,0.06537015217640185,6719]
["Q14061","cytochrome C oxidase copper chaperone [OS=Homo sapiens]",32,2,7,2,63,6.9,7.24,22.8,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","mitochondrion;other cell component","other molecular function","COX17","ENSG00000138495","Oxidative phosphorylation; Metabolic pathways; Thermogenesis","Mitochondrial protein import","Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis; IL-18 signaling pathway; Mitochondrial complex IV assembly",631,667.9,650.6,544.4,616.7,614.4,1.0980005632216276,0.13487879437666417,0.08962224883770027,1.047584162793535,0.2966707503418258,0.5277252699667232,2208]
["Q14108-1","Lysosome membrane protein 2 [OS=Homo sapiens]",27,12,78,12,478,54.3,5.14,208.67,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SCARB2","ENSG00000138760","Lysosome","Cargo recognition for clathrin-mediated endocytosis","Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome",10418.5,10520.1,10564.5,8424.2,8813.4,6991.2,1.300233606286733,0.37877084814143386,0.012031636142311683,1.9196753103774022,0.11465349226095971,0.9406127124424103,767]
["Q14141-1","Septin-6 [OS=Homo sapiens]",47,19,85,9,434,49.7,6.67,271.65,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component","other molecular function","SEPTIN6","ENSCANG00000016430; ENSCATG00000036060; ENSG00000125354; ENSMLEG00000030428; ENSMMUG00000017669; ENSMNEG00000026932; ENSPANG00000000899; ENSPPAG00000040865; ENSRBIG00000044672; ENSRROG00000038667","Bacterial invasion of epithelial cells; Shigellosis","","",13253,12212,12279.3,13888.8,13526.6,11628.1,0.9667242946969407,-0.048823596485708456,0.6072447765173771,0.2166362122814754,0.7258139119485705,0.13917471176980675,6115]
["Q14147","Probable ATP-dependent RNA helicase DHX34 [OS=Homo sapiens]",9,6,8,6,1143,128,7.56,16.79,"RNA metabolism OR transcription;other metabolic processes;other biological processes","","other molecular function","DHX34","ENSG00000134815","","","",450.4,428.3,460.9,500,514.5,436.4,{"$f":"AVERAGE(S2946:U2946)/AVERAGE(V2946:X2946)","v":0.9232889930388033},{"$f":"LOG(Y2946,2)","v":-0.11514580718212661},{"$f":"TTEST(V2946:X2946,S2946:U2946,2,2)","v":0.224370786508159},0.6490336896806717,{"$f":"AA2946*7309/AE2946","v":0.45629551435396054},0.34075380056965365,3594]
["Q14164","Inhibitor of nuclear factor kappa-B kinase subunit epsilon [OS=Homo sapiens]",6,4,5,3,716,80.4,7.84,15.39,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","IKBKE","ENSG00000263528","Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Alcoholic liver disease; Hepatitis C; Hepatitis B; Measles; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease; Chemical carcinogenesis; Lipid and atherosclerosis","Negative regulators of DDX58/IFIH1 signaling; SUMOylation of immune response proteins; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; TICAM1-dependent activation of IRF3/IRF7","Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Cardiac hypertrophic response; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Ebola virus pathway in host; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; STING pathway in Kawasaki-like disease and COVID-19; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Toll-like receptor signaling pathway",339.6,374.6,346.4,353.5,377.3,376.7,0.9576523702031602,-0.06242604518899725,0.3041823430415125,0.5168659991659809,0.5236148717122974,0.28098802711198795,4246]
["Q14197","Peptidyl-tRNA hydrolase ICT1, mitochondrial [OS=Homo sapiens]",8,2,3,2,206,23.6,10.07,7.23,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL58","ENSG00000167862","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",642.6,607.2,686.9,678.9,597.1,447.5,1.1237017696547724,0.16825919522972071,0.3768944450375644,0.42378026347188996,0.5689222426227919,0.24494708669363105,4842]
["Q14204","Cytoplasmic dynein 1 heavy chain 1 [OS=Homo sapiens]",44,185,631,185,4646,532.1,6.4,1919.08,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","DYNC1H1","ENSG00000197102","Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection","Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; COPI-mediated anterograde transport; Neutrophil degranulation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; HCMV Early Events; COPI-independent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Aggrephagy","Ciliary landscape; Intraflagellar transport proteins binding to dynein",69532.3,69395.5,69717.7,64816.8,62724.8,66577,1.074835178081853,0.10411544493572472,0.01231217424886362,1.9096652467515902,0.11551948855576918,0.9373447425401817,779]
["Q14247-1","Src substrate cortactin [OS=Homo sapiens]",4,2,2,2,550,61.5,5.4,3.99,"cell adhesion;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","CTTN","ENSG00000085733; ENSG00000288401","Tight junction; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Proteoglycans in cancer","Clathrin-mediated endocytosis; RHO GTPases activate PAKs","Pathogenic Escherichia coli infection; Hepatitis C and hepatocellular carcinoma",119.6,114,112.2,104,124.9,147.4,0.9189476481530693,-0.12194542042559961,0.4691632241461772,0.32867603785305477,0.6255224380307204,0.20375710717256137,5482]
["Q14331","Protein FRG1 [OS=Homo sapiens]",24,6,20,6,258,29.2,9.01,52.02,"RNA metabolism OR transcription;other metabolic processes;developmental processes","cytoskeleton;nucleus","cytoskeletal activity","FRG1","ENSG00000109536; ENSG00000275145; ENSG00000283153; ENSG00000283630","","","",2842.7,2931.8,2922.1,3293.6,3663.9,2507.4,0.9188264007015394,-0.12213578452112633,0.495755267422583,0.30473266269924343,0.6449760145232573,0.19045643568082976,5618]
["Q14376","UDP-glucose 4-epimerase [OS=Homo sapiens]",40,12,41,12,348,38.3,6.73,131.26,"other metabolic processes","cytosol","other molecular function","GALE","ENSG00000117308","Galactose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars","Galactose catabolism; Defective GALE can cause Epimerase-deficiency galactosemia (EDG)","",4036.2,4167.9,4111.6,3726.5,3343.9,2820,1.2452175847286255,0.31639785553172156,0.03821541111762202,1.4177614639566924,0.1914437559004108,0.717958793966171,1459]
["Q14498-1","RNA-binding protein 39 [OS=Homo sapiens]",31,13,35,13,530,59.3,10.1,115.7,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","LOC101348913; LOC111141906; LOC112827340; Rbm39; RBM39","ENSAMEG00000009940; ENSANAG00000024610; ENSBIXG00000021585; ENSBIXG00005010311; ENSBMUG00000009739; ENSCAFG00000008327; ENSCCAG00000031689; ENSDLEG00000014321; ENSECAG00000013423; ENSFCAG00000003233; ENSG00000131051; ENSGGOG00000003950; ENSHGLG00000017871; ENSLAFG00000010346; ENSLCNG00005002645; ENSMMUG00000031284; ENSMNEG00000040217; ENSMPUG00000017786; ENSOCUG00000007050; ENSPCOG00000027976; ENSPCTG00005007206; ENSPPAG00000029710; ENSPPYG00000010963; ENSPTRG00000049720; ENSRBIG00000044413; ENSRFEG00010016851; ENSRROG00000037484; ENSSSCG00000007309; ENSSSCG00070008152; ENSSSUG00005008586; ENSTTRG00000017039; ENSUAMG00000010443; ENSUMAG00000004302; ENSVVUG00000001290","","","mRNA Processing; VEGFA-VEGFR2 signaling pathway; mRNA processing; mRNA Processing",5156.6,5515.7,5545.3,5212.6,6166.1,4166.8,1.043234376507671,0.06106331494237442,0.7237699127568934,0.1403994745509006,0.8121022862051173,0.09038926689578194,6514]
["Q14554","Protein disulfide-isomerase A5 [OS=Homo sapiens]",40,16,47,16,519,59.6,7.91,140.49,"other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","PDIA5","ENSG00000065485","","XBP1(S) activates chaperone genes","",4338.1,4512.3,4481.6,4043,3801.8,3816.4,1.1432785648132269,0.1931769653286178,4.18687088255385E-3,2.3781104319578286,0.06770318424908427,1.1693909048852378,452]
["Q14596-1","Next to BRCA1 gene 1 protein [OS=Homo sapiens]",7,4,4,4,966,107.3,5.12,7.5,"other metabolic processes;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","NBR1","ENSG00000188554","Mitophagy","Pexophagy","",219.5,203.5,179.1,229.7,259.2,444.7,0.644922879177378,-0.6328014436235746,0.18104486192999558,0.7422137959898275,0.41416491262796173,0.38282669660027346,3195]
["Q14671-3","Isoform 3 of Pumilio homolog 1 [OS=Homo sapiens]",12,12,15,8,1188,126.6,6.84,37.44,"","","","PUM1","","","","",1130,1066.3,1040.1,1799.8,1716.3,1951.3,{"$f":"AVERAGE(S3010:U3010)/AVERAGE(V3010:X3010)","v":0.5919449829900867},{"$f":"LOG(Y3010,2)","v":-0.7564650008841759},{"$f":"TTEST(V3010:X3010,S3010:U3010,2,2)","v":5.449509540632803E-4},3.263642582747527,{"$f":"AA3010*7309/AE3010","v":0.025209155210433647},1.5984417078179767,158]
["Q14677-1","Clathrin interactor 1 [OS=Homo sapiens]",31,20,83,20,625,68.2,6.42,237.51,"cell organization and biogenesis;transport","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","CLINT1","ENSG00000113282","","Golgi Associated Vesicle Biogenesis","",9809.4,9469.7,9117.1,10207.1,10175.5,16984.9,0.7599170402087375,-0.3960861660840667,0.2586992455012541,0.5872048379054889,0.48620025337327494,0.3131848191689758,3889]
["Q14692","ribosome biogenesis protein BMS1 homolog [OS=Homo sapiens]",16,16,27,16,1282,145.7,6.44,68.05,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","BMS1","ENSG00000165733","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",1580.6,1557.1,1496.9,3833.4,3706.4,4388.9,0.3885251536210987,-1.3639200912873357,3.2413104645868333E-4,3.4892793686594654,0.02115244480862961,1.6746394294456741,112]
["Q14764","major vault protein [OS=Homo sapiens]",62,42,250,42,893,99.3,5.48,824.62,"transport;signal transduction;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","MVP","ENSG00000013364","","Neutrophil degranulation","16p11.2 proximal deletion syndrome",28721.4,28844.3,28969.4,28437.7,28053.5,26598.7,1.041463523244101,0.05861231056779434,0.11170945264804098,0.9519100761306751,0.3320391986191669,0.4788106429854194,2459]
["Q14790-4","Isoform 4 of Caspase-8 [OS=Homo sapiens]",50,20,54,9,496,57.7,5.43,187.15,"","","","CASP8","","","","",5153.2,5226.5,5258.4,5193.2,5170.8,4414.9,1.0581369384730934,0.0815263454782845,0.3286573544898678,0.48325664490307274,0.5405392898214321,0.26717273328792973,4444]
["Q14849-1","StAR-related lipid transfer protein 3 [OS=Homo sapiens]",13,4,8,4,445,50.5,8.37,16.7,"cell organization and biogenesis;other metabolic processes;transport","other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","STARD3","ENSG00000131748","Cholesterol metabolism","Pregnenolone biosynthesis","",337.4,338.3,320.4,281.3,258.6,314.9,1.1653018249883014,0.22070367592427553,0.05335729801553657,1.2728061709703262,0.22806344514360044,0.641944319478507,1710]
["Q14966-1","Zinc finger protein 638 [OS=Homo sapiens]",19,29,48,29,1978,220.5,6.38,116.6,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF638","ENSG00000075292","","Transcriptional regulation of white adipocyte differentiation","",3902.8,3796.7,3777.1,4877,5079.3,5580.3,0.7386815648211321,-0.4369755219376411,3.1255473629398225E-3,2.5050739156357382,0.059030040505754944,1.2289269187706768,387]
["Q14999","Cullin-7 [OS=Homo sapiens]",2,3,3,1,1698,191,5.87,8.39,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","CUL7","ENSG00000044090","Ubiquitin mediated proteolysis","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; XBP1(S) activates chaperone genes","",35.3,35.3,38.5,45.8,42.9,94.5,0.5955240174672489,-0.7477684017733368,0.214812453435145,0.6679405446606222,0.4502621801426655,0.3465345301526258,3487]
["Q15006","ER membrane protein complex subunit 2 [OS=Homo sapiens]",34,8,35,8,297,34.8,6.57,87.91,"cell organization and biogenesis","other membranes;ER/Golgi;other cell component","","EMC2","ENSG00000104412","","","",1971.5,2032.4,2057,1963.4,1900.8,1417.7,1.1474848066036842,0.19847505160628873,0.21048530987623085,0.67677820891295,0.4469602352949945,0.3497311130205185,3442]
["Q15011-3","Isoform 3 of Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein [OS=Homo sapiens]",22,4,10,4,232,26.2,5.77,25.63,"","","","HERPUD1","","","","",782.5,748.5,747.6,1239.3,1190.9,1768.9,0.5426400895429973,-0.8819324588997977,0.026022805699686045,1.5846458809411623,0.1594305841232232,0.7974283627275313,1193]
["Q15022","Polycomb protein suz12 [OS=Homo sapiens]",9,5,9,5,739,83,8.81,24.37,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","SUZ12","ENSG00000178691","","HCMV Early Events; Oxidative Stress Induced Senescence; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PRC2 methylates histones and DNA; Defective pyroptosis; PKMTs methylate histone lysines; SUMOylation of chromatin organization proteins; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6","Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Malignant pleural mesothelioma",1192.1,1144.2,1102.4,1606.7,1532.8,1417.3,0.7546304424157303,-0.40615779405509916,3.610881386189025E-3,2.44238677747449,0.06374862814409561,1.1955291567114161,414]
["Q15042-1","Rab3 GTPase-activating protein catalytic subunit [OS=Homo sapiens]",39,31,82,31,981,110.5,5.55,233.69,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","RAB3GAP1","ENSG00000115839","","RAB GEFs exchange GTP for GDP on RABs; COPI-independent Golgi-to-ER retrograde traffic","",7434.9,7531.1,7431.7,7642.9,7442.1,7011.4,1.0136357053637697,0.01953924948478706,0.6234896029650798,0.20517078422640406,0.7375118155157417,0.1322310175570094,6179]
["Q15043","Zinc transporter ZIP14 [OS=Homo sapiens]",9,4,5,4,492,54.2,5.33,18.12,"other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle","transporter activity","SLC39A14","ENSG00000104635","Ferroptosis; Alzheimer disease; Parkinson disease","Zinc influx into cells by the SLC39 gene family","Nuclear receptors meta-pathway; NRF2 pathway; Zinc homeostasis; Ferroptosis",508.4,486.2,502.1,557,597.2,630.6,0.8385813536530702,-0.2539773435145595,0.012540097372476642,1.9016990912433318,0.1158730362774106,0.9360176128570352,791]
["Q15056-1","Eukaryotic translation initiation factor 4H [OS=Homo sapiens]",38,8,31,8,248,27.4,7.23,82.22,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","translation activity;nucleic acid binding activity","EIF4H","ENSG00000106682; ENSPTRG00000019287","","L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Ribosomal scanning and start codon recognition","Translation factors; 7q11.23 copy number variation syndrome",3339,3368.5,3037.1,3574,2889.1,2917.6,1.038792414212159,0.054907383878227696,0.6497269489001384,0.18726911951152814,0.7563074167082516,0.12130164068590404,6279]
["Q15061","WD repeat-containing protein 43 [OS=Homo sapiens]",30,17,45,17,677,74.8,5.57,106.65,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","WDR43","ENSG00000163811","Ribosome biogenesis in eukaryotes","rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol","",3884.3,3952.6,3963.4,4643.9,4496.7,5180.7,0.8239684944802497,-0.27933891976778646,0.015937450850045172,1.7975811415529237,0.12828945843940548,0.8918090281900358,908]
["Q15102","Platelet-activating factor acetylhydrolase IB subunit gamma [OS=Homo sapiens]",41,8,32,8,231,25.7,6.84,85.33,"other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","other molecular function","PAFAH1B3","ENSG00000079462","Ether lipid metabolism; Metabolic pathways","COPI-independent Golgi-to-ER retrograde traffic","",3569.7,3605.7,3708.5,3711.7,3616.1,4676.9,0.9066365673444569,-0.14140374431579306,0.3352106288736326,0.4746822191945547,0.5442146793508177,0.26422974797508286,4502]
["Q15126","phosphomevalonate kinase [OS=Homo sapiens]",78,12,44,12,192,22,5.73,115.47,"other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle","kinase activity;other molecular function","PMVK","ENSG00000163344","Terpenoid backbone biosynthesis; Metabolic pathways; Peroxisome","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Cholesterol biosynthesis pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways",5525.2,5438.4,5824.4,6193.4,5898.1,4596.7,1.0059802734866552,0.008602015260728454,0.9505628051518693,0.02201918334373463,0.9706151917931004,0.012952915513747172,7158]
["Q15154-1","Pericentriolar material 1 protein [OS=Homo sapiens]",31,44,79,44,2024,228.4,5.02,213.04,"","","","","","","","",6166.6,6283.4,6026.6,8225.3,8400.7,8339,0.7401001401962748,-0.4342076052401668,1.800130323333477E-5,4.744696052310157,0.007309529185135767,2.1361105955294906,18]
["Q15185","Prostaglandin E synthase 3 [OS=Homo sapiens]",56,9,100,9,160,18.7,4.54,330.43,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","PTGES3","ENSG00000110958","Arachidonic acid metabolism; Metabolic pathways; Chemical carcinogenesis","HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Estrogen-dependent gene expression; Potential therapeutics for SARS; HSF1 activation; Aryl hydrocarbon receptor signalling; Synthesis of Prostaglandins (PG) and Thromboxanes (TX); Attenuation phase","Aryl hydrocarbon receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway",14561.9,15602.2,14597.8,15081.2,15758,10466.6,1.0836710583017395,0.11592690191797347,0.5344991451062822,0.2720529850780679,0.6729809218917858,0.1719972472686875,5805]
["Q15291-1","Retinoblastoma-binding protein 5 [OS=Homo sapiens]",36,14,34,14,538,59.1,5.1,104.98,"protein metabolism;other metabolic processes;stress response;other biological processes","nucleus","nucleic acid binding activity;other molecular function","LOC101350636; RBBP5","ENSANAG00000037817; ENSBIXG00000017360; ENSBIXG00005000379; ENSBTAG00000015946; ENSCANG00000035291; ENSCHIG00000014205; ENSCJAG00000017172; ENSCSAG00000014601; ENSG00000117222; ENSGGOG00000014796; ENSLCNG00005015908; ENSMFAG00000038790; ENSMLEG00000013766; ENSMMUG00000018803; ENSMNEG00000044153; ENSNLEG00000014409; ENSPANG00000015342; ENSPPAG00000004153; ENSPPYG00000000310; ENSPTRG00000001894; ENSRBIG00000028065; ENSRFEG00010013463; ENSRROG00000045061; ENSSSCG00070019803; ENSSSUG00005002678; ENSTSYG00000000255","Cushing syndrome","Formation of the beta-catenin:TCF transactivating complex; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Neddylation; PKMTs methylate histone lysines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Neddylation; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","",2312.1,2498.9,2460.3,2166.4,2120.1,3806.2,0.8985011182917939,-0.15440779554499848,0.6490065438681903,0.18775092422964973,0.755950411017148,0.12150669249875248,6275]
["Q15293","Reticulocalbin-1 [OS=Homo sapiens]",48,12,47,12,331,38.9,5,138.54,"","ER/Golgi","other molecular function","RCN1","ENSG00000049449","","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","VEGFA-VEGFR2 signaling pathway",6308.4,6673.3,5211.6,6474.4,3947.3,3689.5,1.2892808549237487,0.3665665723649914,0.2417159248257772,0.6166947362860532,0.471623516965191,0.3264045474412988,3746]
["Q15365","Poly(RC)-binding protein 1 [OS=Homo sapiens]",71,18,365,11,356,37.5,7.09,1369.44,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PCBP1","ENSG00000169564","Spliceosome; Ferroptosis","mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA","Ferroptosis",30864.5,32370.8,32739.5,34548,34031,31053.3,0.9632900173939576,-0.05395787972108017,0.3779763760273858,0.4225353432356951,0.5687933564719297,0.24504548482475833,4857]
["Q15369-1","elongin-C [OS=Homo sapiens]",48,4,18,4,112,12.5,4.78,67.62,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","eloc; Eloc; ELOC; eloc.L; LOC101358566; LOC105890220; LOC107550711; LOC107664095; LOC107751353; LOC111156807; LOC113045545; LOC113937395; LOC115195324; Tceb1; TCEB1","ENSACCG00020004765; ENSACUG00000011303; ENSAMEG00000012854; ENSANAG00000026963; ENSBIXG00000018463; ENSBIXG00005018332; ENSBTAG00000050514; ENSCAFG00000008152; ENSCATG00000020385; ENSCATG00000034779; ENSCCAG00000008410; ENSCCAG00000023220; ENSCGRG00001001449; ENSCHIG00000015198; ENSCPOG00000032030; ENSCPRG00005018410; ENSCSAG00000013512; ENSDLEG00000009234; ENSECAG00000000064; ENSEGOG00005000341; ENSELUG00000027740; ENSFCAG00000032823; ENSG00000154582; ENSGAGG00000025908; ENSGALG00000035417; ENSGGOG00000002188; ENSHGLG00000016964; ENSHHUG00000007733; ENSLCNG00005018064; ENSLSDG00000013506; ENSMFAG00000038428; ENSMMDG00005018719; ENSMNEG00000033021; ENSMODG00000006970; ENSMPUG00000010207; ENSMUSG00000079658; ENSOCUG00000032655; ENSOMYG00000017295; ENSOMYG00000030379; ENSPANG00000016947; ENSPCOG00000017567; ENSPCTG00005011391; ENSPMRG00000007569; ENSPPAG00000004063; ENSPPYG00000018678; ENSPSIG00000003701; ENSPTRG00000045560; ENSPTRG00000046987; ENSPTXG00000006319; ENSRBIG00000038767; ENSRFEG00010008700; ENSRNOG00000031730; ENSRROG00000031208; ENSSANG00000000802; ENSSANG00000018252; ENSSBOG00000024839; ENSSFOG00015012880; ENSSFOG00015024826; ENSSGRG00000038413; ENSSGRG00000052876; ENSSHAG00000009970; ENSSHBG00005007386; ENSSRHG00000026121; ENSSRHG00000030142; ENSSSAG00000055027; ENSSSCG00070017636; ENSSSUG00005020214; ENSSTUG00000043851; ENSTMTG00000005512; ENSTSYG00000035894; ENSUAMG00000019951; ENSVURG00010016846; ENSVURG00010021344; ENSXETG00000011828","HIF-1 signaling pathway; Ubiquitin mediated proteolysis; Human immunodeficiency virus 1 infection; Pathways in cancer; Renal cell carcinoma","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Neddylation; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Inactivation of CSF3 (G-CSF) signaling; RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex ; TP53 Regulates Transcription of DNA Repair Genes; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Neddylation; Inactivation of CSF3 (G-CSF) signaling; Neddylation; Antigen processing: Ubiquitination & Proteasome degradation; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Inactivation of CSF3 (G-CSF) signaling; Neddylation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Antigen processing: Ubiquitination & Proteasome degradation; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Inactivation of CSF3 (G-CSF) signaling; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; TP53 Regulates Transcription of DNA Repair Genes; RNA Polymerase II Pre-transcription Events; RNA Polymerase II Transcription Elongation; Inactivation of CSF3 (G-CSF) signaling; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Inactivation of CSF3 (G-CSF) signaling; RNA Polymerase II Pre-transcription Events; Neddylation; Antigen processing: Ubiquitination & Proteasome degradation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA Polymerase II Transcription Elongation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Dual hijack model of Vif in HIV infection; VEGFA-VEGFR2 signaling pathway; Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2",1209.4,1151.3,1137.5,1690.6,1498.7,1803.2,0.7006910365548322,-0.513149653915741,0.005546592860745283,2.2559737116803986,0.07721913756035671,1.1122750532023826,525]
["Q15393-1","Splicing factor 3B subunit 3 [OS=Homo sapiens]",41,40,162,40,1217,135.5,5.26,514.36,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","Sf3b3; SF3B3","ENSANAG00000028001; ENSBIXG00000000514; ENSBTAG00000010627; ENSCATG00000036562; ENSCCAG00000017736; ENSCJAG00000014773; ENSG00000189091; ENSGGOG00000003246; ENSHGLG00000010135; ENSMFAG00000045487; ENSMMUG00000017812; ENSMNEG00000033385; ENSPANG00000024075; ENSPPAG00000026807; ENSPTRG00000008308; ENSRBIG00000021904; ENSRROG00000045703; ENSSBOG00000029156; ENSSTOG00000007065; ENSTSYG00000007910","Spliceosome","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","mRNA Processing; mRNA processing; mRNA Processing",16470.1,17342.5,17227.2,17615.3,17328.4,16420.1,0.9936920554943365,-9.129264069187128E-3,0.8230356915773944,0.08458133086426839,0.8837326090405724,0.053679119584893825,6807]
["Q15435","Protein phosphatase 1 regulatory subunit 7 [OS=Homo sapiens]",44,13,38,13,360,41.5,4.91,122.15,"other biological processes","other cell component","enzyme regulator activity","PPP1R7","ENSG00000115685","","","",3648.2,3900.8,3904.4,3770.2,3464.7,2813.1,1.1398686305732482,0.1888675639150339,0.1871358274614758,0.7278430581479729,0.4207246271657726,0.3760020657601266,3251]
["Q15438-1","Cytohesin-1 [OS=Homo sapiens]",32,13,35,9,398,46.4,5.54,109.11,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","CYTH1","ENSCATG00000038229; ENSG00000108669; ENSMFAG00000037544; ENSMMUG00000013313; ENSPANG00000019854; ENSPTRG00000009717","Phospholipase D signaling pathway; Endocytosis; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection","Intra-Golgi traffic","",2409,2339.9,2371.2,2761.8,2910.7,4420.9,0.705421364455981,-0.5034428248675336,0.13501770458980372,0.8696092796419387,0.3609525979688644,0.4425498279897693,2734]
["Q15542","Transcription initiation factor TFIID subunit 5 [OS=Homo sapiens]",16,8,24,8,800,86.8,5.64,63.3,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","TAF5","ENSG00000148835","Basal transcription factors","RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Regulation of TP53 Activity through Phosphorylation","Eukaryotic transcription initiation",1076,1153.4,1132.8,1224.8,1114.7,790.2,1.0742882704412564,0.10338117258995742,0.5899744316030685,0.22916680946686088,0.7131012271517824,0.1468488161888296,6047]
["Q15633","RISC-loading complex subunit TARBP2 [OS=Homo sapiens]",2,1,1,1,366,39,6.54,2.9,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TARBP2","ENSG00000139546","","MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis","Fragile X syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies",78,83.7,79.1,105.2,99.5,154.4,0.6705653021442495,-0.5765502609049562,0.08750995745055015,1.057942527322995,0.29339921055324364,0.5325410590436267,2180]
["Q15637-5","Isoform 5 of Splicing factor 1 [OS=Homo sapiens]",24,12,53,12,673,71.7,9.58,169.22,"","","","SF1","","","","",5896.4,5552.5,5559.4,6633.8,7174.9,6158.3,0.8518205038313217,-0.23137863804472042,0.03510121579198435,1.4546778407249015,0.18404217089211883,0.735082652602919,1394]
["Q15654-1","thyroid receptor-interacting protein 6 [OS=Homo sapiens]",3,1,1,1,476,50.3,7.37,2.8,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","TRIP6","ENSG00000087077","NOD-like receptor signaling pathway","","",20.2,21.4,19.6,20,19.7,23.4,0.9698890649762281,-0.04410835228989745,0.6514159142954092,0.18614163569092773,0.7575495493373343,0.12058895582893131,6285]
["Q15696","U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 [OS=Homo sapiens]",10,4,6,4,482,58,9.72,17.05,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","ZRSR2","ENSG00000169249","","mRNA Splicing - Minor Pathway","",285.3,307.6,318,292.7,330.3,269.7,1.0203875882155262,0.029117255514397377,0.7780873825769308,0.10897162712350635,0.850843907728125,0.07015010646088707,6684]
["Q15771","Ras-related protein Rab-30 [OS=Homo sapiens]",55,11,24,9,203,23,4.97,71.5,"cell organization and biogenesis;signal transduction","other membranes;ER/Golgi;other cell component","other molecular function","RAB30","ENSG00000137502","","Intra-Golgi traffic; RAB geranylgeranylation","",2236.3,2372.5,2437.7,2138.6,2119.3,2121,1.1046575428365395,0.14359918606376335,0.020286597412321868,1.6927907892885985,0.14326061882769134,0.8438731771975622,1035]
["Q15811-8","Isoform 8 of Intersectin-1 [OS=Homo sapiens]",7,11,19,1,1716,194.7,7.77,55.22,"","","","ITSN1","","","","",1694.1,1680.1,1703.2,1830.6,1785,1324.4,1.0278137651821861,0.03957887893997695,0.7911838470557607,0.10172258795051327,0.86040213333292,0.06529852146731956,6721]
["Q15843","NEDD8 [OS=Homo sapiens]",36,4,24,4,81,9.1,8.43,57.78,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","NEDD8","ENSG00000129559; ENSG00000285246","","Cargo recognition for clathrin-mediated endocytosis; UCH proteinases; Neddylation; Iron uptake and transport; TGF-beta receptor signaling activates SMADs","EGF/EGFR signaling pathway",3092.7,2883.5,2936.8,3109.4,3023.6,4198.4,0.8627097973169174,-0.21305275492887363,0.2849021415057126,0.5453042863146876,0.5098799589288083,0.29253205784558733,4084]
["Q15904","V-type proton ATPase subunit S1 [OS=Homo sapiens]",9,3,5,3,470,52,6.14,14.3,"transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","ATP6AP1","ENSG00000071553","Oxidative phosphorylation; Metabolic pathways; Lysosome; Phagosome; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Tuberculosis; Hepatitis B; Human papillomavirus infection; Rheumatoid arthritis","Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport; RHOA GTPase cycle","Hepatitis B infection; Oxidative phosphorylation",633.6,742.3,700.4,529.8,496.7,329.2,1.5315335251161761,0.6149769477331354,0.026135781906717587,1.5827645025418124,0.15945444904524111,0.797363358711132,1198]
["Q16254","Transcription factor E2F4 [OS=Homo sapiens]",11,4,4,4,413,43.9,4.75,14.49,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","E2F4","ENSG00000205250","Cell cycle; Cellular senescence; TGF-beta signaling pathway","Cyclin D associated events in G1; G1/S-Specific Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest","Cell cycle; Adipogenesis; TGF-beta signaling pathway",428.2,411.8,381.7,512.9,538.4,462.5,0.8070418813581716,-0.30928455092592366,0.020359291991409876,1.691237328966431,0.14322046695400845,0.8439949146396355,1039]
["Q16401","26S proteasome non-ATPase regulatory subunit 5 [OS=Homo sapiens]",46,16,61,16,504,56.2,5.48,181.89,"cell organization and biogenesis","cytosol;nucleus;other cell component","","PSMD5","ENSG00000095261","","Degradation of DVL; Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Parkin-ubiquitin proteasomal system pathway",6947.7,7092.4,7090.9,6357.4,6393.7,5341.4,1.1679425176177975,0.22396927114560863,0.0437313585484528,1.3592070307518318,0.2063476434026091,0.685400486627065,1549]
["Q16540","39S ribosomal protein L23, mitochondrial [OS=Homo sapiens]",13,1,1,1,153,17.8,9.69,2.29,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus","nucleic acid binding activity;other molecular function","MRPL23","ENSG00000214026; ENSG00000288141","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",23.2,22.3,23,21.5,27,58.3,0.6413857677902621,-0.640735753839665,0.3278324538917645,0.48434805549877397,0.5402767543393251,0.2673837177825462,4435]
["Q16563","Synaptophysin-like protein 1 [OS=Homo sapiens]",10,2,2,2,259,28.5,8.43,6.69,"cell-cell signaling","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","SYPL1","ENSG00000008282","","","",372.2,317.6,295.9,307,370.5,360.5,0.9496146435452794,-0.07458591263788544,0.593083494222256,0.226884162407303,0.7153213299126187,0.14549882468961628,6060]
["Q16629","serine/arginine-rich splicing factor 7 [OS=Homo sapiens]",37,11,91,10,238,27.4,11.82,225.6,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","nucleus;other cell component","other molecular function","SRSF7","ENSG00000115875","Spliceosome; Amyotrophic lateral sclerosis; Herpes simplex virus 1 infection","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Minor Pathway","mRNA processing",12147.9,12022.9,11711.7,11498.8,12349.7,12064.5,0.9991507253640743,-1.2257648848225259E-3,0.9729370705270058,0.01191524894716683,0.98384021146678,0.007075430952088088,7228]
["Q16690","Dual specificity protein phosphatase 5 [OS=Homo sapiens]",6,1,1,1,384,42,8.35,3.41,"protein metabolism;other metabolic processes;developmental processes;signal transduction","nucleus;other cell component","other molecular function","DUSP5","ENSG00000138166","MAPK signaling pathway","Negative regulation of MAPK pathway; RAF-independent MAPK1/3 activation","Endoderm differentiation; VEGFA-VEGFR2 signaling pathway",13.2,18.6,15.3,34.1,31.9,62.5,0.3665369649805448,-1.4479693944684573,0.05302976793350406,1.2754802734173443,0.22772889178964817,0.6425818672819404,1702]
["Q16763","ubiquitin-conjugating enzyme E2 S [OS=Homo sapiens]",18,4,6,4,222,23.8,8.38,19.55,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","UBE2S","ENSG00000108106","Ubiquitin mediated proteolysis","APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; APC-Cdc20 mediated degradation of Nek2A; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; APC/C:Cdc20 mediated degradation of Securin; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","",514.6,490.2,554.2,533.5,584,2408.6,0.4421315334221945,-1.1774524619537445,0.34785860129978796,0.4585972536234164,0.5502052622592838,0.2594752602581484,4621]
["Q16774-1","guanylate kinase [OS=Homo sapiens]",47,8,28,8,197,21.7,6.55,84.33,"other metabolic processes;transport","cytosol;other cell component","kinase activity;other molecular function","GUK1","ENSG00000143774","Purine metabolism; Metabolic pathways","Interconversion of nucleotide di- and triphosphates; Abacavir metabolism","",3357.5,3495.3,3542,3237.1,3625.1,1651.9,1.22089240201548,0.2879360603426955,0.35940941842871965,0.4444105462642571,0.5590388251320518,0.252558029403236,4699]
["Q16854","Deoxyguanosine kinase, mitochondrial [OS=Homo sapiens]",3,1,3,1,277,32,8.66,8.22,"protein metabolism;other metabolic processes;other biological processes","cytosol;mitochondrion;other cell component","kinase activity;other molecular function","DGUOK","ENSG00000114956","Purine metabolism; Metabolic pathways","Purine salvage","",135.6,199.1,170.7,151.5,140.2,163.8,1.109549945115258,0.14997461025536202,0.44363648537516265,0.35297274398024897,0.6080140768061248,0.21608636577915266,5333]
["Q16864-1","V-type proton ATPase subunit F [OS=Homo sapiens]",33,3,7,3,119,13.4,5.52,19.7,"transport","other membranes;cytosol;other cytoplasmic organelle","transporter activity;other molecular function","ATP6V1F","ENSCATG00000033101; ENSG00000128524; ENSGGOG00000023527; ENSMLEG00000037581; ENSPPAG00000012238; ENSPPAG00000027671; ENSPTRG00000019672; ENSPTRG00000040903","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis","ROS and RNS production in phagocytes; Amino acids regulate mTORC1; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Proximal tubule transport",758.1,732.4,811.1,995.1,1154.3,1079.6,0.7127903375658098,-0.48845031476205625,3.874566489249423E-3,2.411776882024488,0.06647701049277942,1.177328519243234,426]
["Q17RN3-1","Protein Fam98c [OS=Homo sapiens]",5,2,3,2,349,37.3,7.18,6.77,"","other cell component","","FAM98C","ENSG00000130244","","","",177.9,176.4,194.7,173.7,190.4,409.7,0.7094856552080641,-0.4951545795506555,0.3814475634618554,0.4185651548633818,0.5700266287758539,0.24410485580069113,4891]
["Q29963","HLA class I histocompatibility antigen, Cw-6 alpha chain [OS=Homo sapiens]",46,14,120,3,366,40.9,6,477.31,"other biological processes","plasma membrane;other membranes","","HLA-C","ENSG00000228299","","","",12609.6,12135.5,12285.1,10055.8,10727.7,17440.5,0.9687683131017161,-0.04577641738467544,0.8743723731897259,0.058303572879946364,0.9176892124703773,0.03730437344126696,6964]
["Q2KHR3-1","Glutamine and serine-rich protein 1 [OS=Homo sapiens]",0,1,1,1,1735,189.9,7.08,0,"","","","QSER1","ENSG00000060749","","","",16,16.8,12.3,15.7,15.6,13.1,1.0157657657657657,0.022567756905274912,0.892844592842532,0.04922412716342862,0.9310602267207971,0.03102222526299996,7009]
["Q2NKX8","Dna excision repair protein ercc-6-like [OS=Homo sapiens]",23,21,34,21,1250,141,5.31,102.91,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","ERCC6L","ENSG00000186871","","RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",2648.7,2648.2,2475,2524.6,2567.5,5268.8,0.7501182329720391,-0.41481008504037337,0.3964192725023948,0.4018452398124415,0.5792539909476216,0.23713096532295228,5002]
["Q2TAL8","Glutamine-rich protein 1 [OS=Homo sapiens]",6,4,7,4,776,86.4,5.87,22.38,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cell component","nucleic acid binding activity","QRICH1","ENSG00000198218","","","",661.9,663.9,666,759.8,692.5,536.7,1.0014077425842132,0.002029515062631491,0.9894074600973534,0.004624819394416211,0.9937582968052158,0.002719232431894986,7277]
["Q2TB10","zinc finger protein 800 [OS=Homo sapiens]",21,12,19,12,664,75.2,9.47,45.09,"","nucleus","nucleic acid binding activity;other molecular function","ZNF800","ENSG00000048405","","","",1520,1357.4,1354.5,1635.6,1579.6,1762.9,0.8501034531246859,-0.23428967454522268,0.031991864500757056,1.4949604482937062,0.1778163784304436,0.7500282392355099,1315]
["Q32MZ4-3","Isoform 3 of Leucine-rich repeat flightless-interacting protein 1 [OS=Homo sapiens]",52,30,133,27,752,82.6,4.61,441.23,"","","","LRRFIP1","","","","",12310.6,12408.4,11061.5,14100.8,14601.2,13843.5,0.8409937596220517,-0.24983299951481594,0.009826786677956143,2.0075884716056622,0.10394208947783132,0.9832085570958876,691]
["Q32P28-1","Prolyl 3-hydroxylase 1 [OS=Homo sapiens]",4,3,6,3,736,83.3,5.14,16.19,"protein metabolism;other metabolic processes;developmental processes;other biological processes","ER/Golgi;nucleus;other cell component","other molecular function","P3H1","ENSG00000117385","","Collagen biosynthesis and modifying enzymes","Type I collagen synthesis in the context of osteogenesis imperfecta",643.6,674.6,642.2,687.9,732.5,557.1,0.9913527180783819,-0.01252964283775995,0.920553954622289,0.03595075196384783,0.9503289342280098,0.022126047769643928,7080]
["Q3B820-3","Isoform 3 of Protein FAM161A [OS=Homo sapiens]",5,3,4,2,716,83.4,8.66,10.04,"","","","FAM161A","","","","",67.3,58,68.7,86,83.5,90.5,0.7461538461538462,-0.4224549708413268,0.005012783061853177,{"$f":"-LOG10(AA3331)","v":2.299921089936861},0.07357114738772062,{"$f":"-LOG10(AC3331)","v":1.1332924708126053},498]
["Q3MHD2","Protein LSM12 homolog [OS=Homo sapiens]",18,4,11,4,195,21.7,7.74,27.54,"","","","LSM12","ENSG00000161654","","","",749.9,739.9,794.6,1263.9,1260.4,1284.1,0.5998319504253755,-0.7373697245770252,1.0163949815833957E-5,4.992937487931014,6.753482654902763E-3,2.170472211205267,11]
["Q3SXM5","Inactive hydroxysteroid dehydrogenase-like protein 1 [OS=Homo sapiens]",9,3,13,3,330,37,8.72,40.46,"","cytoskeleton;mitochondrion;other cell component","other molecular function","HSDL1","ENSG00000103160","","","",1147.4,1195.5,1135.6,1079.3,900.2,901.6,1.2073513588559925,0.2718455848861033,0.03289539292113234,1.4828649217774976,0.17929338319206284,0.7464357377451236,1341]
["Q460N5-1","Isoform 1 of Poly [ADP-ribose] polymerase 14 [OS=Homo sapiens]",3,3,3,3,1720,193.6,7.97,6.48,"","","","PARP14","","","","",50.2,50.1,48.5,46.5,52.5,57.8,0.9489795918367346,-0.07555103300717692,0.4656475265500558,0.33194269961019796,0.6224246107451277,0.20591324362200963,5468]
["Q49MG5","Microtubule-associated protein 9 [OS=Homo sapiens]",2,2,3,2,647,74.2,7.8,3.64,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;other cell component","cytoskeletal activity","MAP9","ENSG00000164114","","","",422,404.8,415.2,672.8,630.8,260.3,0.7941684250911184,-0.3324830922093248,0.4592328370996346,0.3379670655985393,0.617804676304294,0.20914880874828712,5433]
["Q4G0F5","Vacuolar protein sorting-associated protein 26B [OS=Homo sapiens]",25,9,32,7,336,39.1,7.36,93.1,"stress response;transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","VPS26B","ENSG00000151502","Endocytosis","","",2692,2687.6,2705,2717.9,2493.8,1622.7,1.182927543017675,0.24236170805600765,0.28029612483394145,0.5523829064311849,0.5053488841665709,0.2964086889042018,4054]
["Q4KMP7","TBC1 domain family member 10B [OS=Homo sapiens]",21,13,41,13,808,87.1,9.19,100.53,"transport;other biological processes","plasma membrane;other membranes;cytosol","enzyme regulator activity","TBC1D10B","ENSG00000169221","","TBC/RABGAPs","",2754,2659.8,2700.3,2559.6,2741.8,4049.2,0.8677624965242874,-0.20462785863775906,0.42995064517165205,0.3665813950246329,0.5992580597939751,0.22238611615870651,5244]
["Q4KMQ1","Taperin [OS=Homo sapiens]",12,4,4,4,711,75.5,7.25,13.69,"cell organization and biogenesis;developmental processes;other biological processes","other cell component","other molecular function","TPRN","ENSG00000176058","","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea","",277.6,295,298.5,283.9,319.4,286.7,0.9787640449438202,-0.030966990133321198,0.6557097085896868,0.18328838602127864,0.7608481124118147,0.11870203248717832,6299]
["Q504Q3","PAN2-PAN3 deadenylation complex catalytic subunit PAN2 [OS=Homo sapiens]",7,6,10,6,1202,135.3,5.99,31.96,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PAN2","ENSG00000135473","RNA degradation","Deadenylation of mRNA","Ectoderm differentiation; Ectoderm differentiation",448.1,458,468,459.6,526,485.4,0.9341264445955132,-0.09831024661841738,0.18440590631768303,0.7342251730866232,0.41792954086075823,0.3788969301739368,3225]
["Q53EZ4-1","Centrosomal protein of 55 kDa [OS=Homo sapiens]",21,9,13,9,464,54.1,7.01,32.64,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cell component","other molecular function","CEP55","ENSG00000138180","","","",762.5,685.5,839.7,978.3,1000.4,1511.2,0.6555202154789536,-0.6092878227217557,0.0895707404455092,1.0478338356318069,0.2967690579855969,0.5275813818520058,2206]
["Q53FT3","Protein Hikeshi [OS=Homo sapiens]",15,3,8,3,197,21.6,5.45,23.91,"cell organization and biogenesis;stress response;transport;developmental processes","cytosol;nucleus","other molecular function","HIKESHI","ENSG00000149196","","Regulation of HSF1-mediated heat shock response","",755.6,892.8,897.8,712.9,786.5,662.9,1.1775424316699807,0.23577904697768812,0.09519203515562558,1.0213993880931542,0.30623177154598036,0.5139497532481625,2272]
["Q53H47","Histone-lysine N-methyltransferase SETMAR [OS=Homo sapiens]",6,4,5,4,684,78,7.14,13.3,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SETMAR","ENSG00000170364","Lysine degradation; Metabolic pathways","","Histone modifications",335.1,356,379.3,350.6,392.1,510.5,0.8541334184487711,-0.22746665372959293,0.28640787515413896,0.5430150447127654,0.5099525358103779,0.29247024428425206,4105]
["Q53QZ3","Rho GTPase-activating protein 15 [OS=Homo sapiens]",23,10,14,10,475,54.5,9.39,36.96,"signal transduction;other biological processes","other membranes;cytosol;other cell component","enzyme regulator activity","ARHGAP15","ENSG00000075884","","RAC1 GTPase cycle; RAC3 GTPase cycle","Ectoderm differentiation; Ectoderm differentiation",984.3,992.7,1036.2,1023.6,968.2,1111.1,0.9710915595088466,-0.04232076811829577,0.5393048729362357,0.26816565558842415,0.6762359437795414,0.16990174902389615,5829]
["Q53S33","BolA-like protein 3 [OS=Homo sapiens]",7,1,1,1,107,12.1,9.64,2.1,"","cytosol;mitochondrion;nucleus","","BOLA3","ENSG00000163170","","","",69.9,79.5,81.1,69.6,75.2,54.8,1.1548096192384767,0.20765502997943946,0.21614283739309123,0.6652591516741522,0.45136799957317253,0.3454692341404549,3500]
["Q567V2-1","Mpv17-like protein 2 [OS=Homo sapiens]",5,1,1,1,206,23.2,9.25,0,"cell organization and biogenesis;other biological processes","other membranes;mitochondrion;translational apparatus;other cell component","","FKSG24; MPV17L2","ENSG00000254858; ENSGGOG00000008883; ENSPPAG00000039781; ENSPTRG00000010696","Peroxisome","","",127.1,124.9,133.8,160,183.3,496.3,0.45950452596474506,-1.1218490232430511,0.2355731182165011,0.6278742693871435,0.4649754040087514,0.3325700195526131,3703]
["Q56VL3","OCIA domain-containing protein 2 [OS=Homo sapiens]",55,9,40,9,154,16.9,9.03,115.42,"transport;other biological processes","ER/Golgi;other cytoplasmic organelle","","OCIAD2","ENSG00000145247","","","",3775.1,3901,3981.3,4296.2,4016.7,3990,0.9475326955433274,-0.07775236913989689,0.13428039802490147,0.871987380115698,0.36016712996844213,0.4434959248443862,2725]
["Q5BKT4","Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase [OS=Homo sapiens]",1,1,1,1,473,55.6,9.29,1.85,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","ALG10","ENSG00000139133","N-Glycan biosynthesis; Metabolic pathways","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein","",61.8,71.1,71.7,64.5,69.9,65.4,1.0240240240240237,0.034249561952909874,0.6808425260914961,0.1669533256172545,0.7805926310906267,0.1075755528392743,6375]
["Q5F1R6","DnaJ homolog subfamily C member 21 [OS=Homo sapiens]",23,10,15,10,531,62,5.47,39.69,"other biological processes","cytosol;translational apparatus;nucleus","other molecular function","DNAJC21","ENSG00000168724","","","",1384.4,1301.1,1280.2,1381.4,1536.1,1555.5,0.8865861837692822,-0.17366721463418555,0.056507228609000974,1.2478959921063275,0.23479893911494493,0.6293038696798159,1759]
["Q5GJ75","Tumor necrosis factor alpha-induced protein 8-like protein 3 [OS=Homo sapiens]",10,2,2,2,292,32.6,8.59,4.37,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","transporter activity;other molecular function","TNFAIP8L3","ENSG00000183578","","PI Metabolism","",55.8,54.3,55.2,53.8,50.9,74,0.9250139899272525,-0.11245290974917661,0.5725901229580184,0.24215614772522484,0.7019559222912037,0.15369015753786378,5962]
["Q5HYK3-1","2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial [OS=Homo sapiens]",24,6,13,6,327,37.1,6.95,36.6,"other metabolic processes","other membranes;mitochondrion;other cell component","other molecular function","COQ5","ENSG00000110871","Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways; Biosynthesis of cofactors","Ubiquinol biosynthesis","",750,767.2,753.8,724.6,672.4,2468.3,0.5875352495278503,-0.7672526852633843,0.4187656146399916,0.37802898598362483,0.5930551981018599,0.22690488316960367,5161]
["Q5JRA6-1","Transport and Golgi organization protein 1 homolog [OS=Homo sapiens]",40,63,179,63,1907,213.6,4.84,539.69,"cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","MIA3","ENSG00000154305","","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cargo concentration in the ER","Type I collagen synthesis in the context of osteogenesis imperfecta",17075.5,16771.8,16830.1,17858.1,18942.9,17829.9,0.9276325303079394,-0.1083746814460966,0.025211224950672014,1.59840605252295,0.15722597539629843,0.8034757023210488,1172]
["Q5JS54-1","Proteasome assembly chaperone 4 [OS=Homo sapiens]",30,3,5,3,123,13.8,6.52,15.87,"cell organization and biogenesis","other cell component","other molecular function","PSMG4","ENSG00000180822; ENSGGOG00000012606; ENSPTRG00000033938","","","",612.8,539.4,507.9,673.8,575.4,556.4,0.91941736818786,-0.12120817534802006,0.36809254052521884,0.43404298353556864,0.5642593076130085,0.2485212683837757,4768]
["Q5JTJ3-1","Cytochrome c oxidase assembly factor 6 homolog [OS=Homo sapiens]",11,1,1,1,125,14.1,8.25,2.19,"cell organization and biogenesis;other metabolic processes","plasma membrane;other membranes;mitochondrion;nucleus","other molecular function","COA6","ENSG00000168275; ENSPTRG00000002122","Thermogenesis","Mitochondrial protein import","Mitochondrial complex IV assembly",16.4,15.4,25.3,15.8,17.9,30.8,0.8852713178294572,-0.1758084149477739,0.6848059389135305,0.1644324819375173,0.784152688002349,0.1055993644833496,6383]
["Q5JTW2-1","Centrosomal protein of 78 kDa [OS=Homo sapiens]",9,5,5,5,689,76.3,8.18,17.8,"cell organization and biogenesis","cytosol;cytoskeleton","","CEP78","ENSG00000148019","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","Ciliopathies",366.7,404.2,400.3,551.9,547.2,519.7,0.7234988880652335,-0.4669372953853812,6.6330708446336048E-4,3.1782853641867526,0.028023765782327757,1.552473505431575,173]
["Q5JWF2-1","Guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas [OS=Homo sapiens]",17,14,58,1,1037,111,5.03,185.46,"cell adhesion;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","GNAS","ENSG00000087460","","G alpha (i) signalling events; G alpha (z) signalling events; G alpha (s) signalling events; ADORA2B mediated anti-inflammatory cytokines production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Prostacyclin signalling through prostacyclin receptor; Glucagon-type ligand receptors; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation in glucagon signalling; Hedgehog 'off' state","Thyroid stimulating hormone (TSH) signaling pathway; Endothelin pathways; Corticotropin-releasing hormone signaling pathway; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; G protein signaling pathways; Thermogenesis; Hippo signaling regulation pathways; Purinergic signaling; Prostaglandin and leukotriene metabolism in senescence ; Calcium regulation in cardiac cells; Estrogen signaling pathway; Serotonin receptor 4/6/7 and NR3C signaling",5775.2,5933.8,6118.9,5142.9,5283.6,4193.7,1.2194019233663014,0.28617372667601754,0.039933827948062973,1.398659057523195,0.19628537220739226,0.7071120641611762,1487]
["Q5MNZ9","WD repeat domain phosphoinositide-interacting protein 1 [OS=Homo sapiens]",7,1,4,1,446,48.6,6.6,18.58,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport","other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","WIPI1","ENSG00000070540","Autophagy; Autophagy; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis","XBP1(S) activates chaperone genes; Macroautophagy","Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Alzheimer's disease",44.2,43.9,47.7,41,42.5,145.1,0.5940507436570429,-0.7513419239697464,0.420290543021818,0.3764503819661232,0.5933752325567835,0.2266705850640061,5177]
["Q5PSV4","Breast cancer metastasis-suppressor 1-like protein [OS=Homo sapiens]",5,2,4,2,323,37.6,5.15,9.87,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","BRMS1L","ENSG00000100916","","","Genotoxicity pathway",405.1,417.6,457.9,420.3,470.5,1098.3,0.6438087577296264,-0.6352958929596776,0.34095875651969265,0.46729815150370185,0.5469858541269609,0.26202390502679157,4556]
["Q5RKV6","Exosome complex component MTR3 [OS=Homo sapiens]",42,12,34,12,272,28.2,6.28,112.9,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cytoplasmic organelle;other cell component","","EXOSC6","ENSG00000223496","RNA degradation","Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease","",3217.2,3252.7,3378.5,3278.4,3511.4,4961.6,0.8380618479500314,-0.25487137788604197,0.2965131115475759,0.5279560977571832,0.5178528870492789,0.2857935982024891,4185]
["Q5SRD1","Putative mitochondrial import inner membrane translocase subunit Tim23B [OS=Homo sapiens]",14,2,6,2,257,28,9.39,26.68,"","","","","","","","",552.7,625.3,564.4,782.6,655.4,874.7,0.7534051109093268,-0.40850227469134504,0.047890102625223196,1.319754232292945,0.21713942933483643,0.6632613078780438,1612]
["Q5SSJ5-1","Heterochromatin protein 1-binding protein 3 [OS=Homo sapiens]",48,24,119,24,553,61.2,9.67,300.56,"cell organization and biogenesis;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HP1BP3","ENSG00000127483; ENSPPAG00000040189; ENSPTRG00000000296","","","",22662.4,21469.1,21214.1,18053.8,18472,15989.1,1.244324943968283,0.31536328115624107,8.54101276372758E-3,2.0684906291212863,0.09604040352320752,1.0175460238801688,650]
["Q5SZL2","Centrosomal protein of 85 kDa-like [OS=Homo sapiens]",1,1,3,1,805,91.8,6.33,5.03,"developmental processes","cytoskeleton;other cell component","","CEP85L","ENSG00000111860","","","",651.3,612.5,608.5,550.5,695.9,240.7,1.259027637684083,0.33230995288387905,0.3951630287234674,0.403223694581574,0.5789229458688763,0.23737923663678262,4989]
["Q5T0D9","Tumor protein p63-regulated gene 1-like protein [OS=Homo sapiens]",31,3,10,3,272,30.2,7.34,53.52,"other biological processes","other membranes;ER/Golgi;other cell component","","TPRG1L","ENSG00000158109","","","",423.3,402.4,398.2,391.5,387.6,441.3,1.0028679121599475,0.004131600944354555,0.9538606968897353,0.02051504562036155,0.9727595693549708,0.011994488205928897,7167]
["Q5T3I0","G patch domain-containing protein 4 [OS=Homo sapiens]",36,16,26,16,446,50.4,9.63,81.55,"","","","GPATCH4","","","","",2212.7,2255.4,2254,2980.1,3238.9,3530.2,0.6895027284289993,-0.5363718342529674,3.195717686408773E-3,2.49543159376678,0.060044988611726795,1.2215232332085146,389]
["Q5T4S7-1","e3 ubiquitin-protein ligase UBR4 [OS=Homo sapiens]",24,98,284,98,5183,573.5,6.04,848.76,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus","other molecular function","UBR4","ENSG00000127481","Human papillomavirus infection; Viral carcinogenesis","Neutrophil degranulation; Antigen processing: Ubiquitination & Proteasome degradation","",25956.1,26022.9,25999.8,24102.5,23574.9,25234.9,1.0694875898853828,0.09691974186275912,0.0261488683286189,1.5825471017975137,0.15940123320590122,0.7975083230123895,1199]
["Q5T5U3","rho GTPase-activating protein 21 [OS=Homo sapiens]",2,2,2,2,1957,217.2,7.8,7.72,"","","","","","","","",71.2,66.4,65.3,79.3,75,456.2,0.33235053235053236,-1.5892224301181068,0.34283345088049383,0.46491680978252853,0.5478289664375884,0.26135500816928525,4574]
["Q5T6V5","queuosine salvage protein [OS=Homo sapiens]",11,4,6,4,341,39,5.88,14.13,"RNA metabolism OR transcription;other metabolic processes","","","C9orf64","ENSG00000165118","","","",538.1,542.3,550.5,563.6,486.9,358.5,1.1574875798438609,0.2109967130588993,0.28475686651733156,0.5455257947128402,0.5098696563878433,0.29254083320891894,4082]
["Q5TAQ9-1","DDB1- and CUL4-associated factor 8 [OS=Homo sapiens]",20,12,20,12,597,66.8,5.39,49.73,"protein metabolism;other metabolic processes","cytosol;mitochondrion;nucleus;other cell component","","DCAF8","ENSG00000132716; ENSPPAG00000008803; ENSPTRG00000001546","","Neddylation","",2726.5,2860,2954.8,2433.9,2456.1,2119,1.2186189185333143,0.2852470428602207,0.016013970796772213,1.7955009678116292,0.12862210170726165,0.8906843982487498,910]
["Q5TC12-1","ATP synthase mitochondrial F1 complex assembly factor 1 [OS=Homo sapiens]",14,4,11,4,328,36.4,7.96,31.61,"cell organization and biogenesis","mitochondrion","","ATPAF1","ENSG00000123472","","","7q11.23 copy number variation syndrome",764.1,789.9,835.5,792,827.2,515.8,1.1192037470725995,0.16247269773861323,0.44674863385986585,0.3499367668761042,0.6097639150105993,0.2148382801600057,5355]
["Q5TF39","Sodium-dependent glucose transporter 1 [OS=Homo sapiens]",6,2,2,2,518,56.2,5.43,6.55,"transport","plasma membrane;other membranes","transporter activity","MFSD4B","ENSG00000173214","","Cellular hexose transport","",244.9,236,236.4,206.2,205.9,270.3,1.0511430246189917,0.07195898411449379,0.6189480489783852,0.2083458016888571,0.7338023179210085,0.1344209207366346,6165]
["Q5TGZ0","MICOS complex subunit Mic10 [OS=Homo sapiens]",10,1,2,1,78,8.8,8.5,5.26,"cell organization and biogenesis","mitochondrion","","MICOS10","ENSG00000173436","","Cristae formation","",389.6,349,406.9,350.9,305.7,184,1.3627171068284558,0.4464860970400631,0.12608024105120008,0.8993529695316616,0.35159117964258735,0.4539620285942891,2621]
["Q5VIR6-4","Isoform 4 of Vacuolar protein sorting-associated protein 53 homolog [OS=Homo sapiens]",26,17,47,17,832,94.3,6.7,140.26,"transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","VPS53","ENSG00000141252; ENSG00000283883","","Retrograde transport at the Trans-Golgi-Network","",3898.5,3917.8,3891.6,3855.7,3837.7,3836.5,1.0154381217530075,0.022102328102792324,0.004047231384300949,2.3928419658450233,0.06647463862439469,1.177344014941982,445]
["Q5VTE6-1","protein angel homolog 2 [OS=Homo sapiens]",11,5,8,5,544,62.3,7.81,15.84,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ANGEL2","ENSG00000174606; ENSPPAG00000031266; ENSPTRG00000001970","","","",588.6,605,580.7,566.8,553.2,427.7,1.1464108031272209,0.19712410991910975,0.16743423806849062,0.7761557298325112,0.3994049758624667,0.39858652890910456,3064]
["Q5VTY9-1","Protein-cysteine N-palmitoyltransferase HHAT [OS=Homo sapiens]",3,1,1,1,493,57.3,7.28,3.27,"protein metabolism;other metabolic processes;signal transduction","other membranes;ER/Golgi","other molecular function","HHAT","ENSG00000054392; ENSG00000280680","Hedgehog signaling pathway","Hedgehog ligand biogenesis; HHAT G278V doesn't palmitoylate Hh-Np","",58.7,66.8,63.1,51.6,65.1,56.5,1.0889145496535797,0.1228907459483717,0.3258415365145881,0.4869935549898416,0.5383308748610137,0.26895071140251037,4424]
["Q5VW32","BRO1 domain-containing protein BROX [OS=Homo sapiens]",27,10,25,10,411,46.4,7.65,66.72,"","other membranes","","BROX","ENSG00000162819","","","",4312.6,4367.8,4461.2,4128.8,3936.4,2853.4,1.2035975308189697,0.26735305209721294,0.13709817113582437,0.862968338579687,0.36385277154384177,0.439074312616619,2754]
["Q5VYS8-1","terminal uridylyltransferase 7 [OS=Homo sapiens]",20,22,38,21,1495,171.1,6.83,111.51,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TUT7","ENSG00000083223","","Deadenylation of mRNA","",2910.6,2994.1,2950.1,3878.7,3931.4,3905.8,0.7557934089570582,-0.403936157536416,4.766438264575639E-6,5.32180602763454,0.011612632425261116,1.9350693204702287,3]
["Q5VZE5","N-alpha-acetyltransferase 35, NatC auxiliary subunit [OS=Homo sapiens]",10,5,5,5,725,83.6,7.05,14.31,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","","NAA35","ENSG00000135040","","Retrograde transport at the Trans-Golgi-Network","",179,171,181.4,170.3,173.1,273.2,0.8618228997729486,-0.21453666161666834,0.45040087617384184,0.3464007733141378,0.6118921940436077,0.2133250870965541,5380]
["Q5W0Z9-1","Probable palmitoyltransferase ZDHHC20 [OS=Homo sapiens]",5,1,2,1,365,42.3,7.71,5.62,"protein metabolism;other metabolic processes;transport","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","ZDHHC20","ENSG00000180776; ENSPPYG00000005201","","","",68.9,66,65.3,64.9,73.8,185.9,0.6167590881084412,-0.697221025711978,0.34705402091850307,0.45960291955840316,0.5501231487515374,0.2595400798938377,4611]
["Q5XKP0","MICOS complex subunit MIC13 [OS=Homo sapiens]",75,5,22,5,118,13.1,9.42,65.16,"cell organization and biogenesis","other membranes;mitochondrion;nucleus","","MICOS13","ENSG00000174917","","Cristae formation","",2736.1,2632.4,2559.7,2745.9,2400.8,4536.8,0.8187328961635771,-0.288535231826529,0.42798654794756896,0.3685698810895207,0.597660236711651,0.22354563750940995,5234]
["Q63ZY3-1","KN motif and ankyrin repeat domain-containing protein 2 [OS=Homo sapiens]",3,2,3,2,851,91.1,5.63,9.86,"developmental processes;other biological processes","mitochondrion;other cell component","","KANK2","ENSG00000197256","","","",171,148.8,170.5,179.5,205.8,246.4,0.7761595694158618,-0.36557481059472163,0.0859958095851618,1.0655227105980594,0.29166745812433764,0.5351120232108367,2155]
["Q66K14-1","TBC1 domain family member 9B [OS=Homo sapiens]",14,14,25,12,1250,140.4,5.25,84.37,"transport;other biological processes","other membranes","enzyme regulator activity;other molecular function","TBC1D9B","ENSG00000197226; ENSG00000284400","","","",1565.5,1654.6,1600.1,1432.5,1442.3,1248.5,1.1690151092571484,0.22529357649873216,0.027069469300547534,1.5675202585295687,0.16297425956977094,0.7878809833848344,1214]
["Q676U5","Autophagy-related protein 16-1 [OS=Homo sapiens]",12,6,7,6,607,68.2,6.64,17.74,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","ATG16L1","ENSG00000085978; ENSG00000281089","Autophagy; Autophagy; NOD-like receptor signaling pathway; Shigellosis","Macroautophagy","Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; LDLRAD4 and what we know about it; Autophagy; Senescence and autophagy in cancer",481.2,470.2,433.5,404.9,438.9,602,0.9578779914234334,-0.06208618879869038,0.7616692322347028,0.11823358745580935,0.8398009380605587,0.0758236445893666,6629]
["Q68CZ6","HAUS augmin-like complex subunit 3 [OS=Homo sapiens]",4,3,4,3,603,69.6,5.55,2.05,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","non-structural extracellular;cytosol;cytoskeleton;mitochondrion;nucleus","","HAUS3","ENSG00000214367","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",251.8,247.6,244.1,238.9,259.9,73.6,1.2989168413696717,0.37730907021311344,0.3881223496443941,0.41103134811862246,0.5736675942468912,0.24133968216784765,4945]
["Q68DQ2","very large A-kinase anchor protein [OS=Homo sapiens]",5,13,14,13,2970,330.4,5.2,33.18,"developmental processes;other biological processes","other cell component","other molecular function","CRYBG3","ENSG00000080200","","","",1001.4,1034.2,1002.6,1106.4,1246.4,1336.5,0.8235166562762583,-0.2801302649914169,0.032864931716217044,1.4832672657204748,0.17926103426405252,0.7465141022013094,1340]
["Q69YH5-1","cell division cycle-associated protein 2 [OS=Homo sapiens]",23,18,40,17,1023,112.6,8.4,106.03,"cell cycle OR cell proliferation;other biological processes","cytosol;nucleus;other cell component","","CDCA2","ENSG00000184661","","","",3771.9,3753.1,3587.3,2862.2,2915.8,4265.1,1.1064611524330137,0.1459527993756201,0.4841082699684225,{"$f":"-LOG10(AA3651)","v":0.3150574982907902},0.6358216253727224,{"$f":"-LOG10(AC3651)","v":0.1966647050775444},5565]
["Q6BCY4","NADH-cytochrome b5 reductase 2 [OS=Homo sapiens]",4,1,1,1,276,31.4,8.5,2.31,"other metabolic processes;transport","other membranes;ER/Golgi","other molecular function","CYB5R2","ENSG00000166394","Amino sugar and nucleotide sugar metabolism","Erythrocytes take up carbon dioxide and release oxygen","Oxidation by cytochrome P450",57.4,69.7,80.8,74,60.3,48.6,1.136686714051394,0.1848346831096533,0.4505682722573689,0.346239393323866,0.6118921408266647,0.21332512486762872,5382]
["Q6DD87","Zinc finger protein 787 [OS=Homo sapiens]",14,3,5,3,383,40.5,7.84,20.81,"","","","","","","","",620.9,596.1,611.7,617.3,722.8,619.7,0.9331054189202981,-0.09988801406535176,0.28598023504826947,0.5436639812279194,0.5100608926226944,0.2923779734091226,4098]
["Q6DT37","Serine/threonine-protein kinase MRCK gamma [OS=Homo sapiens]",4,5,5,5,1551,172.4,6.28,16.18,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction","cytosol;cytoskeleton;other cell component","kinase activity;other molecular function","CDC42BPG","ENSG00000171219","","","",429.8,373.9,394.7,499.8,468.7,724.4,0.7078976903538307,-0.49838722650675654,0.11537775583745877,0.9378779125687815,0.3378589813365329,0.4712645316951949,2496]
["Q6IA69","glutamine-dependent NAD(+) synthetase [OS=Homo sapiens]",14,8,12,8,706,79.2,6.44,32.21,"other metabolic processes","cytosol;other cell component","other molecular function","NADSYN1","ENSG00000172890","Nicotinate and nicotinamide metabolism; Metabolic pathways; Biosynthesis of cofactors","Nicotinate metabolism","NAD biosynthesis II (from tryptophan); NAD+ biosynthetic pathways",795.1,745.4,812.9,792.5,839.6,724.2,0.9987692568857955,-1.7766805305394126E-3,0.9814685950765467,0.008123592348404327,0.988228951841091,0.005142426867729155,7259]
["Q6IAN0","Dehydrogenase/reductase SDR family member 7B [OS=Homo sapiens]",23,6,11,6,325,35.1,9.55,27.45,"other metabolic processes","other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","DHRS7B","ENSG00000109016","","Plasmalogen biosynthesis","",1081.9,1157.9,1178.9,1030.5,1020,1536.2,0.9531602866144369,-0.06920925193867354,0.7622160666365667,0.11792190104002226,0.8397704599105618,0.07583940633951276,6634]
["Q6IEG0-1","U11/U12 small nuclear ribonucleoprotein 48 kDa protein [OS=Homo sapiens]",2,1,1,1,339,39.9,6.95,1.64,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","other molecular function","SNRNP48","ENSG00000168566","","mRNA Splicing - Minor Pathway","",114.4,104.6,110.1,111.7,109.8,159.8,0.8630999213217938,-0.21240050460176613,0.3537887330920572,0.45125600193466653,0.5545446815719164,0.25606345550518567,4663]
["Q6JQN1","Acyl-CoA dehydrogenase family member 10 [OS=Homo sapiens]",2,2,2,2,1059,118.8,8.06,3.95,"other metabolic processes","mitochondrion","other molecular function","ACAD10","ENSG00000111271","","Mitochondrial Fatty Acid Beta-Oxidation","",139.8,145.1,142.3,123.2,133.3,186.3,0.964769647696477,-0.051743575093998254,0.8041591364720362,0.0946579994445005,0.8702397288235286,0.06036109385992027,6754]
["Q6KCM7-3","Isoform 3 of Calcium-binding mitochondrial carrier protein SCaMC-2 [OS=Homo sapiens]",14,6,14,6,515,56.8,8.46,36.72,"","","","SLC25A25","","","","",1074.8,1109.7,1148.4,1120.5,1208.3,2127.7,0.7478738920677662,-0.4191330742754226,0.31047251608690457,0.5079768387727222,0.528961216801675,0.2765761690734734,4290]
["Q6NT16","MFS-type transporter SLC18B1 [OS=Homo sapiens]",2,1,1,1,456,48.8,5.22,2.8,"transport","other membranes","transporter activity","SLC18B1","ENSG00000146409","","","",87,87.1,78,71,63,59.7,1.3014971605575634,0.3801721642552862,0.01249961462061144,1.9031033766496999,0.11608600160362009,0.9352201471247914,787]
["Q6NUK1","Calcium-binding mitochondrial carrier protein SCaMC-1 [OS=Homo sapiens]",32,14,38,14,477,53.3,6.33,111,"stress response;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","SLC25A24","ENSG00000085491; ENSG00000284468","","","",4393,4741.9,4884.3,3989.5,4226,3767.7,1.1699045330128848,0.22639080727170194,0.026172930892991497,1.582147641541189,0.15941495991406238,0.797470925704841,1200]
["Q6NW29","RWD domain-containing protein 4 [OS=Homo sapiens]",11,2,3,2,188,21.2,5.31,8.35,"","","","RWDD4","ENSG00000182552","","","",291.7,278.4,285.7,378.6,393.2,504.5,0.6705320065815247,-0.5766218967854012,0.024690302699188076,1.6074735856540858,0.1553024289400737,0.8088217518244248,1162]
["Q6NXR4","TELO2-interacting protein 2 [OS=Homo sapiens]",24,10,19,10,508,56.9,7.09,61.94,"","cytosol;cytoskeleton;nucleus","","TTI2","ENSG00000129696","","","",1471.5,1452,1438.4,1596.3,1613.9,1698.2,0.8886602558878657,-0.17029612783231735,0.005189801815145169,2.2848492263966738,0.07466980603719693,1.12685497679662,508]
["Q6P0N0","Mis18-binding protein 1 [OS=Homo sapiens]",3,3,3,3,1132,129,9.25,5.18,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","nucleic acid binding activity","MIS18BP1","ENSG00000129534","","Deposition of new CENPA-containing nucleosomes at the centromere","",151.8,173,174,202.9,206.1,571.1,0.508927660442812,-0.974467490329549,0.26019576440591236,0.58469977737517,0.4875085470501957,0.31201776580298834,3901]
["Q6P1L8","39S ribosomal protein L14, mitochondrial [OS=Homo sapiens]",13,1,1,1,145,15.9,10.24,5.95,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL14","ENSG00000180992","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",35.6,38.5,40.9,34.3,45.7,52.2,0.8698940998487142,-0.20108831567595384,0.35225139203497113,0.45314728196051646,0.5529650825566159,0.2573022917183756,4656]
["Q6P1X5","Transcription initiation factor TFIID subunit 2 [OS=Homo sapiens]",6,6,9,6,1199,136.9,8.19,23.55,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","TAF2","ENSG00000064313","Basal transcription factors","Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation","",510.9,532.7,557.3,547,540.5,737.8,0.8770613049909605,-0.1892504069319301,0.32093584326694347,0.4935817766291721,0.5357971855728848,0.270999571977112,4378]
["Q6P1X6","UPF0598 protein C8orf82 [OS=Homo sapiens]",24,4,5,4,216,23.9,9.14,16.32,"","","","C8orf82","ENSG00000213563","","","",270.1,249,291.6,283.5,230.3,341.8,0.9475222066386163,-0.07776833943267712,0.6865172065124237,0.16334857335839614,0.7856198939093947,0.10478752763240824,6387]
["Q6P3X3","tetratricopeptide repeat protein 27 [OS=Homo sapiens]",25,16,26,16,843,96.6,5.59,62.23,"","","","TTC27","ENSG00000018699","","","",2204.8,2253.7,2114.6,2135.3,2182.2,1707.7,1.0909347407554937,0.12556480284910299,0.30766257240834033,0.5119253330836631,0.5265056758914913,0.27859694262651413,4271]
["Q6P4E1","Protein CASC4 [OS=Homo sapiens]",32,16,37,16,433,48.8,5.82,88.85,"","","","","","","","",3783,3738.1,3807.2,4092.6,4348.4,5297.2,0.8245840066384241,-0.27826161543096334,0.09380008549823447,1.0277967657638512,0.30362481173897066,0.5176627414688272,2258]
["Q6P6C2-2","RNA demethylase ALKBH5 [OS=Homo sapiens]",24,6,10,6,394,44.2,9.09,30.01,"RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes","cytosol;ER/Golgi;nucleus","other molecular function","ALKBH5","ENSCSAG00000008183; ENSG00000091542; ENSMFAG00000001517; ENSMMUG00000018352; ENSMNEG00000037007; ENSPANG00000023682; ENSPPAG00000030479; ENSPTRG00000024216; ENSRBIG00000029698; ENSRROG00000033654","","Reversal of alkylation damage by DNA dioxygenases","",914.9,934.8,930,1064,1033.6,1287.4,0.8211816838995569,-0.284226645767649,0.06573900523097716,1.1821768719910248,0.25302074209226544,0.5968438748440693,1899]
["Q6PD62","RNA polymerase-associated protein CTR9 homolog [OS=Homo sapiens]",14,15,24,15,1173,133.4,6.77,58.56,"cell-cell signaling;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","nucleus;other cell component","other molecular function","CTR9","ENSG00000198730","","E3 ubiquitin ligases ubiquitinate target proteins; RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex","Endoderm differentiation",2125,2157.5,2068,2809.9,2564.6,3508.2,0.7149290193297083,-0.4841280817296901,0.041005346236731126,1.3871595167011177,0.198745408252167,0.7017028963509,1508]
["Q6PGP7","Tetratricopeptide repeat protein 37 [OS=Homo sapiens]",26,38,67,38,1564,175.4,7.53,178.13,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","","TTC37","ENSG00000198677","RNA degradation","mRNA decay by 3' to 5' exoribonuclease","",6163.1,6192.4,6240.2,6128.1,5979.8,6596.4,0.9941938484733456,-0.00840091818545162,0.8560634650000319,0.06749403733499883,0.9058879203250665,0.042925531457172754,6907]
["Q6PII5-1","Hydroxyacylglutathione hydrolase-like protein [OS=Homo sapiens]",2,1,1,1,290,31.5,8.21,2.02,"","","other molecular function","HAGHL","ENSG00000103253","","","Orexin receptor pathway",178.9,181.3,201.9,201.9,185.8,367.2,0.7446019340309975,-0.4254587314332235,0.333109037968774,0.4774135838002164,0.5428526105939285,0.2653180692963543,4485]
["Q6PJG6-1","BRCA1-associated ATM activator 1 [OS=Homo sapiens]",23,12,25,12,821,88.1,5.27,67.16,"cell cycle OR cell proliferation;other metabolic processes;stress response;other biological processes","nucleus;other cell component","","BRAT1","ENSG00000106009","","","",1195.1,1249.9,1265.3,1502.1,1409,1604.8,0.8216080958391462,-0.28347769734829015,0.011298154538645654,1.9469924891835084,0.11025128374227114,0.957616344999002,749]
["Q6PJI9-1","GATOR complex protein WDR59 [OS=Homo sapiens]",4,3,3,3,974,109.7,7.91,9.14,"stress response;other biological processes","other membranes;other cytoplasmic organelle;other cell component","","WDR59","ENSG00000103091","mTOR signaling pathway","Amino acids regulate mTORC1","",255.9,262.5,276.4,248.9,250.8,341,0.9454026406565956,-0.08099920051356817,0.6473212979770626,0.18888010371627537,0.7549499548291607,0.12208183653227347,6267]
["Q6Q0C0-1","E3 ubiquitin-protein ligase TRAF7 [OS=Homo sapiens]",2,1,1,1,670,74.6,7.15,3.82,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","TRAF7","ENSG00000131653","","Antigen processing: Ubiquitination & Proteasome degradation","",42.5,45.6,41.7,42.5,57.8,45.8,0.8884325804243671,-0.17066579480435942,0.32077382933869875,0.49380107130253253,0.5357714622112772,0.27102042274393395,4376]
["Q6QNY1","biogenesis of lysosome-related organelles complex 1 subunit 2 [OS=Homo sapiens]",21,1,3,1,142,16,4.86,11.69,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","BLOC1S2","ENSG00000196072","","","Genotoxicity pathway",48.1,36.9,47,83.3,114.1,26.1,0.5906040268456377,-0.759736901824864,0.30628622664019556,0.5138725325066936,0.5253804342908213,0.2795261048231739,4261]
["Q6SZW1","Sterile alpha and TIR motif-containing protein 1 [OS=Homo sapiens]",8,4,6,4,724,79.3,6.55,17.3,"other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;other cell component","other molecular function","SARM1","ENSG00000004139","","","Regulation of toll-like receptor signaling pathway",321.6,330,328.2,316.3,305.4,528.7,0.8517037552155771,-0.2315763841564469,0.4779717060913736,0.3205978110282081,0.6316209003474688,0.19954350761340076,5531]
["Q6UW02","Cytochrome P450 20A1 [OS=Homo sapiens]",35,13,34,13,462,52.4,6.21,71.7,"","other membranes","other molecular function","CYP20A1","ENSG00000119004","","","Oxidation by cytochrome P450; Metapathway biotransformation Phase I and II",3078,3072.2,3114.1,2653.4,2775.9,2638.3,1.1483340770489363,0.19954241656643498,9.3301816656455585E-4,3.030109900131386,0.032944105214591006,1.4822222837043306,207]
["Q6UWI2","Prostate androgen-regulated mucin-like protein 1 [OS=Homo sapiens]",7,1,3,1,310,32.3,4.68,13.41,"other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","","PARM1","ENSG00000169116","","","",92.4,84.4,74.8,123.1,111.3,254.9,0.5142039648477418,-0.959587360553751,0.1622391179413916,0.789844423504473,0.3940863120749854,0.4044086493605807,3009]
["Q6UWP7-1","Lysocardiolipin acyltransferase 1 [OS=Homo sapiens]",9,3,5,3,414,48.9,8.62,18.6,"other metabolic processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","LCLAT1","ENSG00000172954","Glycerolipid metabolism; Glycerophospholipid metabolism; Metabolic pathways","Synthesis of PA; Acyl chain remodeling of CL","",367.8,381,361.6,327,368.6,399,1.01443449661977,0.02067571137077303,0.8196704661165881,0.08636071287442539,0.8816735006396089,0.05469221205896554,6795]
["Q6UXV4","MICOS complex subunit MIC27 [OS=Homo sapiens]",47,8,19,8,268,29.1,9.52,61.94,"cell organization and biogenesis","non-structural extracellular;other membranes;mitochondrion;other cell component","","APOOL","ENSG00000155008","","Platelet degranulation ; Cristae formation","",2160.1,1999.1,2044.1,1902.9,1916.6,1422.9,{"$f":"AVERAGE(S3842:U3842)/AVERAGE(V3842:X3842)","v":1.1832939111857164},{"$f":"LOG(Y3842,2)","v":0.24280846044467988},{"$f":"TTEST(V3842:X3842,S3842:U3842,2,2)","v":0.13140629394691575},0.8813838329425043,{"$f":"AA3842*7309/AE3842","v":0.3567788270646386},0.4476009266104707,2692]
["Q6V1X1","Dipeptidyl peptidase 8 [OS=Homo sapiens]",9,6,11,5,898,103.3,5.8,24.15,"protein metabolism;other biological processes","cytosol;other cell component","other molecular function","DPP8","ENSG00000074603","","","",444.5,396.7,401.9,426.3,409.7,484.3,0.9415284405059455,-0.08692342027390691,0.3979080699083963,{"$f":"-LOG10(AA3843)","v":0.4002172529090366},0.5799222498425659,{"$f":"-LOG10(AC3843)","v":0.2366302283815006},5015]
["Q6Y1H2","Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 [OS=Homo sapiens]",9,2,10,2,254,28.4,9.55,22.85,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","HACD2","ENSG00000206527","Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism","Synthesis of very long-chain fatty acyl-CoAs","",1207.6,1226.5,1136.8,933.8,927,1353.2,1.1110454262601122,0.15191780403610725,0.4538831743690812,0.34305591642900096,0.6137709752939158,0.21199365283435712,5405]
["Q6YHK3-1","CD109 antigen [OS=Homo sapiens]",2,2,2,2,1445,161.6,5.85,5.29,"developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol","enzyme regulator activity;other molecular function","CD109","ENSG00000156535","","Platelet degranulation ; Post-translational modification: synthesis of GPI-anchored proteins","",29.3,37.1,40.1,36.7,25.6,114.5,0.6023755656108597,-0.7312648442782311,0.4520027068119167,0.3448589644143722,0.612588129814259,0.21283142281856163,5393]
["Q6ZMS4","Zinc finger protein 852 [OS=Homo sapiens]",18,7,10,3,543,62,8.12,25.13,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF852","ENSG00000178917; ENSG00000281626","","","",1264.5,1262.6,1264.4,1531.1,1638.5,658.2,0.9905167459114895,-0.013746729021223534,0.9707746121928191,0.012881589909879134,0.9826051295550914,0.007620973020598609,7221]
["Q6ZQN7","Solute carrier organic anion transporter family member 4C1 [OS=Homo sapiens]",5,2,2,2,724,78.9,7.53,6.93,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle","transporter activity","SLCO4C1","ENSG00000173930","","Neutrophil degranulation; Transport of organic anions","",112.7,96.5,91.6,117.3,143.8,202.2,0.6492553421109432,-0.6231421153556342,0.10444128921584486,0.9811277759158137,0.3199335217429213,0.4949402533661637,2386]
["Q6ZSR9","Uncharacterized protein FLJ45252 [OS=Homo sapiens]",15,4,6,4,355,38,5.26,18.58,"","","","","","","","",320,307.2,320.6,401.7,378.9,961.2,0.544149730164198,-0.877924411715217,0.23699946796719995,0.625252628923097,0.46640525346587625,0.3312365664428856,3714]
["Q6ZT07","TBC1 domain family member 9 [OS=Homo sapiens]",2,3,3,1,1266,143.1,5.31,4.78,"transport;other biological processes","","enzyme regulator activity;other molecular function","TBC1D9","ENSG00000109436","","","",54.9,48.3,46.5,68.7,77.2,94.5,0.6227121464226288,-0.683362674652769,0.01951979665009908,1.7095247109623533,0.14125761754017246,0.8499881228610229,1010]
["Q6ZVF9","G protein-regulated inducer of neurite outgrowth 3 [OS=Homo sapiens]",23,13,20,13,776,82.4,7.56,69.33,"cell organization and biogenesis;developmental processes","plasma membrane;other membranes","","GPRIN3","ENSG00000185477","","","",1667.9,1650.5,1620.3,2739.6,2930.8,3050.3,0.5663192174940085,-0.8203126077726415,1.6113730536873686E-4,3.7928039031548795,0.01490826031569744,1.8265730325613478,79]
["Q6ZVK8-1","8-oxo-dGDP phosphatase NUDT18 [OS=Homo sapiens]",24,6,8,6,323,35.5,6.23,28.93,"other metabolic processes","cytosol","other molecular function","NUDT18","ENSG00000275074; ENSPTRG00000020049","","","",373.5,378.9,352,372.8,349.9,1518.9,0.49268379728765166,-1.021266067842749,0.38167533389216324,0.41830590581108934,0.5699009224551218,0.24420064006627298,4895]
["Q70CQ3","ubiquitin carboxyl-terminal hydrolase 30 [OS=Homo sapiens]",2,1,1,1,517,58.5,8.27,2.23,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle","other molecular function","USP30","ENSG00000135093","Mitophagy","Ub-specific processing proteases; Pexophagy","",136.6,123.8,110.7,124.6,114.4,139.7,0.9799313440718246,-0.029247420186893587,0.8209402220254657,0.08568846552326305,0.8823900121741366,0.0543394163455264,6800]
["Q70IA6-1","MOB kinase activator 2 [OS=Homo sapiens]",8,2,5,2,237,26.9,6.79,14.96,"other metabolic processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","MOB2","ENSCATG00000043655; ENSCSAG00000009929; ENSG00000182208","","","",684.5,635.9,629.7,687.7,671.8,722.1,0.9368274404304382,-0.0941447607293587,0.12709236092850557,0.8958805525640067,0.35320078556138673,0.45197833916979163,2630]
["Q71RC2","La-related protein 4 [OS=Homo sapiens]",8,5,8,5,724,80.5,6.61,23.37,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity","LARP4","ENSG00000161813","","","",687.9,701.9,700.2,1382.8,1445.9,1287.4,0.5077622020844974,-0.9777750903998665,1.282738582586226E-4,3.891861842228506,0.013587733768293805,1.8668529710817883,69]
["Q76I76","Protein phosphatase Slingshot homolog 2 [OS=Homo sapiens]",3,2,2,2,1423,158.1,5.41,7.71,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SSH2","ENSG00000141298","Axon guidance; Regulation of actin cytoskeleton","","Regulation of actin cytoskeleton",89.7,103.8,94.1,90,90.1,236.6,0.6901847852171826,-0.5349454242632509,0.4296424401054018,0.36689282555518393,0.598942703553382,0.22261472138493432,5243]
["Q7L014","probable ATP-dependent RNA helicase DDX46 [OS=Homo sapiens]",46,46,192,45,1031,117.3,9.29,604.08,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus","other molecular function","DDX46","ENSG00000145833","Spliceosome","mRNA Splicing - Major Pathway","",22793.6,22938.2,23116.2,22540.3,22738.4,19559.7,1.0618398973447833,0.0865662551070394,0.26512496678921826,0.5765493728771174,0.49220177349819566,0.3078568257833739,3937]
["Q7L0Y3","Mitochondrial ribonuclease P protein 1 [OS=Homo sapiens]",38,16,56,16,403,47.3,9.36,174.21,"RNA metabolism OR transcription;other metabolic processes;other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","TRMT10C","ENSG00000174173","","tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion","",7669.8,7756.4,8085.6,6857,7254.7,5249.9,1.2143521196595326,0.28018681337957607,0.09155841658827027,1.0383017266235652,0.3002245252775538,0.5225538332198301,2229]
["Q7L2J0-1","7SK snRNA methylphosphate capping enzyme [OS=Homo sapiens]",30,13,34,13,689,74.3,9.57,115.51,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MEPCE","ENSG00000146834","","","IL-18 signaling pathway",2281.3,2067.7,2194.3,2596.3,2620.8,3753.8,0.7293916998294484,-0.4552343123822788,0.10460162016050395,0.9804615886875071,0.3201562988915927,0.4946379492608656,2388]
["Q7L2Z9","Centromere protein Q [OS=Homo sapiens]",15,3,5,3,268,30.6,9.42,19.29,"cell cycle OR cell proliferation;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","","CENPQ","ENSG00000031691","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Deposition of new CENPA-containing nucleosomes at the centromere","",283.8,246.3,279.2,290.6,318.1,302.2,0.8884619606982104,-0.1706180859793318,0.07622473672259772,1.11790406699696,0.2735034858642449,0.563037134113151,2037]
["Q7L5D6","Golgi to ER traffic protein 4 homolog [OS=Homo sapiens]",20,7,23,7,327,36.5,5.41,65.88,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","GET4","ENSG00000239857","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",1760.1,1746.4,1693.3,1651.8,1477.8,1927.7,1.0281770905423844,0.04008877196735499,0.7381996473468302,0.13182616661172747,0.821733357060308,0.08526908312107574,6566]
["Q7L8L6","FAST kinase domain-containing protein 5, mitochondrial [OS=Homo sapiens]",7,4,8,4,764,86.5,8.13,30.2,"RNA metabolism OR transcription;other metabolic processes;other biological processes","mitochondrion;other cell component","nucleic acid binding activity","FASTKD5","ENSG00000215251","","","",512.6,500.5,479.3,470,491.7,657.8,0.9215189873417722,-0.11791420286576897,0.5197853364553061,0.284175976444033,0.6624430730866316,0.1788514367973465,5735]
["Q7LBC6-1","Lysine-specific demethylase 3B [OS=Homo sapiens]",14,15,21,15,1761,191.5,7.18,59.58,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KDM3B","ENSG00000120733","Thermogenesis","HDMs demethylate histones","Thermogenesis",1197.3,1181.6,1186.4,1460.1,1442.7,1951.7,0.7344319703368007,-0.4452992332455945,0.061672428544524795,1.2099089495351063,0.24524688804784098,0.6103964947012258,1838]
["Q7Z2E3-4","Isoform 4 of Aprataxin [OS=Homo sapiens]",33,7,22,7,254,29.1,8.59,61.07,"","","","APTX","","","","",1675.7,1697.3,1678,1682.1,1633.9,1614.5,1.024439711996755,0.03483508462973641,0.13146557429902983,0.8811879570550111,0.3568072345160078,0.4475663485825485,2693]
["Q7Z2Z1","Treslin [OS=Homo sapiens]",0,1,2,1,1910,210.7,8.78,0,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","TICRR","ENSG00000140534","","","",62.1,77.6,89.5,88.5,92.2,69.6,0.9157011586096684,-0.12705124693142703,0.5425051980121908,0.2655960962680111,0.6785028220860887,0.1684483416462973,5844]
["Q7Z392","trafficking protein particle complex subunit 11 [OS=Homo sapiens]",8,8,9,8,1133,128.8,7.14,27.94,"cell organization and biogenesis;transport;other biological processes","cytosol;ER/Golgi;other cell component","","TRAPPC11","ENSG00000168538","","RAB GEFs exchange GTP for GDP on RABs","Genes related to primary cilium development (based on CRISPR)",609.7,594.9,576.6,610.9,579.4,871.1,0.8640729601241873,-0.21077495985358077,0.3717171480368157,0.4297874035908958,0.5661347436968297,0.24708019163934428,4799]
["Q7Z3K3-1","Pogo transposable element with ZNF domain [OS=Homo sapiens]",11,13,34,13,1410,155.2,7.4,119.03,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","POGZ","ENSG00000143442; ENSPTRG00000001289","","","",2768.5,2782,2906.1,2664,2700.4,2824.5,1.0326905933641881,0.04640806999893331,0.24419010212749545,0.6122719434973138,0.4737949180912833,0.3244096018166085,3767]
["Q7Z3K6-1","Mesoderm induction early response protein 3 [OS=Homo sapiens]",5,2,2,2,550,61.4,4.51,6.44,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","MIER3","ENSG00000155545; ENSGGOG00000015237","","","",18.7,21.2,18.7,33.8,30,25,0.6599099099099099,-0.5996590119278581,0.019863971582770413,1.701933914751057,0.1420604386482084,0.8475268486657779,1022]
["Q7Z434","Mitochondrial antiviral-signaling protein [OS=Homo sapiens]",40,11,31,11,540,56.5,5.52,126.96,"stress response;signal transduction;other biological processes","other membranes;mitochondrion;other cytoplasmic organelle","other molecular function","MAVS","ENSG00000088888","NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; Hepatitis C; Hepatitis B; Measles; Influenza A; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease","Ovarian tumor domain proteases; TRAF6 mediated NF-kB activation; Negative regulators of DDX58/IFIH1 signaling; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10","Novel intracellular components of RIG-I-like receptor (RLR) pathway; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation",1360.3,1335.1,1232.8,1411.2,1440.1,2001.7,0.8094374613641045,-0.3050084753418857,0.1910753000308328,0.7187954498032643,0.42513527181898236,0.37147286181509087,3285]
["Q7Z4G4","tRNA (guanine(10)-N2)-methyltransferase homolog [OS=Homo sapiens]",3,2,2,2,463,53.4,7.78,4.86,"RNA metabolism OR transcription;other metabolic processes","other cell component","nucleic acid binding activity;other molecular function","TRMT11","ENSG00000066651","","tRNA modification in the nucleus and cytosol","",313,323.9,340.2,352.9,323.1,356.1,0.9467105900591029,-0.07900463445202474,0.23565821239561457,0.6277174210180644,0.4647668306528729,0.33276487411697014,3706]
["Q7Z4H8","KDEL motif-containing protein 2 [OS=Homo sapiens]",2,1,1,1,507,58.5,8.24,0,"protein metabolism;other metabolic processes","ER/Golgi;other cell component","other molecular function","POGLUT3","ENSG00000178202","","","",210,215.4,186.7,197.2,201.5,103.9,1.2178670911261438,0.2843566969259082,0.33120866404291593,0.47989831108759723,0.541324715002163,0.2665421440819911,4472]
["Q7Z5D8","NANOG neighbor homeobox [OS=Homo sapiens]",4,1,1,1,188,22.7,9.72,2.13,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NANOGNB","ENSG00000205857","","","Pre-implantation embryo",79.2,77.6,78.8,69,80.4,135.7,0.8263767099263416,-0.275128500107492,0.4680959263876115,0.32966513831088246,0.6246691849492518,0.20434991735569472,5477]
["Q7Z5U6","WD repeat-containing protein 53 [OS=Homo sapiens]",13,2,2,2,358,39,6.52,11.19,"","","","WDR53","ENSG00000185798","","","3q29 copy number variation syndrome",80.6,81.7,75,83.5,87.3,141.8,0.7591170825335893,-0.39760567780571626,0.25584529442898063,0.5920225662717781,0.484825837952144,0.314414243253847,3857]
["Q7Z5W3","Pre-miRNA 5'-monophosphate methyltransferase [OS=Homo sapiens]",3,1,1,1,292,33.2,6.7,2.56,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","BCDIN3D","ENSG00000186666","","MicroRNA (miRNA) biogenesis","",74.9,69.3,82.8,102.2,111.6,105.9,0.7100406631216766,-0.49402644660224304,0.002939973672310333,2.5316565587108153,0.05684726870612758,1.2452903966640676,378]
["Q7Z6K3","Protein prenyltransferase alpha subunit repeat-containing protein 1 [OS=Homo sapiens]",4,1,1,1,402,46.4,6.99,2.39,"protein metabolism;other metabolic processes","other cell component","other molecular function","PTAR1","ENSG00000188647","","","",88.7,99.6,107.3,116,103.8,96,0.936035465484484,-0.09536490171408575,0.44399373760836536,0.3526231554288729,0.6082755816643941,0.2158996173053886,5335]
["Q7Z6L1-1","Tectonin beta-propeller repeat-containing protein 1 [OS=Homo sapiens]",9,6,7,6,1165,129.6,6.24,25,"cell organization and biogenesis;other metabolic processes","other membranes;nucleus;other cytoplasmic organelle;other cell component","other molecular function","TECPR1","ENSG00000205356","Shigellosis","","",338.9,336.8,324.9,298,373.1,370.7,0.9604530620080631,-0.05821298475799937,0.6123552437329908,0.21299655884592358,0.7294172875561327,0.13702394790287512,6136]
["Q7Z7A3","Cytoplasmic tRNA 2-thiolation protein 1 [OS=Homo sapiens]",10,2,3,2,348,36.4,9.2,9.81,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol","nucleic acid binding activity;other molecular function","CTU1","ENSG00000142544","Sulfur relay system","tRNA modification in the nucleus and cytosol","",283,253.8,285.3,319.8,318.2,540.9,0.6973449826109084,-0.5200555484461346,0.186378566095636,0.7296040338362523,0.41979689972049417,0.3769607730886674,3245]
["Q7Z7H8","39S ribosomal protein L10, mitochondrial [OS=Homo sapiens]",33,5,16,5,261,29.3,9.58,50.63,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus;other cell component","other molecular function","MRPL10","ENSG00000159111","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1330.8,1339.3,1458.6,1131.5,1042.9,1058.3,1.2771676926408266,0.3529479639270175,0.003800269900187652,2.4201855581201266,0.06597665724577564,1.180609692071822,421]
["Q7Z7L1","Schlafen family member 11 [OS=Homo sapiens]",21,12,30,10,901,102.8,7.77,80.77,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SLFN11","ENSG00000172716","","","",2238.2,2189,2239.7,2455.9,2255.5,2785.8,0.8892519874086324,-0.16933580128606834,0.14969659506517227,0.8247880778214383,0.38030323716765524,0.4198699778277913,2877]
["Q86TG7-1","Retrotransposon-derived protein PEG10 [OS=Homo sapiens]",22,12,39,4,708,80.1,6.39,131.72,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PEG10","ENSG00000242265","","","",3665.3,3522.9,3625.3,1321.2,1361.4,2135.8,2.244209696164702,1.1662074858765483,0.001739510667305571,2.7595729036581336,0.044926089990588045,1.3475013772984508,283]
["Q86TU7","Histone-lysine N-methyltransferase setd3 [OS=Homo sapiens]",15,8,12,8,594,67.2,5.96,42.46,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","cytoskeletal activity;other molecular function","SETD3","ENSG00000183576","","PKMTs methylate histone lysines","Histone modifications",1058.8,1074.8,1118.8,1100.7,1092,1005.9,1.0168198586881758,0.024064111843371108,0.6369887120710145,0.1958682636280819,0.7473114761680649,0.1264983484032786,6230]
["Q86U38","Nucleolar protein 9 [OS=Homo sapiens]",16,9,15,9,636,69.4,7.28,32,"RNA metabolism OR transcription;other metabolic processes;transport","nucleus;other cell component","","NOP9","ENSG00000196943; ENSG00000285326","","","",929.8,944.2,977.9,1059.3,1056.1,1537.4,0.7807435392028034,-0.35707936916042765,0.17165342597102734,0.7653475242192145,0.40393267560278134,0.39369101372778126,3106]
["Q86UD5","Sodium/hydrogen exchanger 9B2 [OS=Homo sapiens]",3,1,1,1,537,57.5,6.71,2.37,"transport;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle","transporter activity;other molecular function","SLC9B2","ENSG00000164038","","Stimuli-sensing channels","",34.8,36.2,30.8,31.7,38.2,54,0.8216303470540757,-0.2834386260649066,0.34061544321074755,0.46773566538937295,0.5469152623961674,0.2620799568924147,4552]
["Q86UF1","Tetraspanin-33 [OS=Homo sapiens]",5,1,2,1,283,31.5,7.17,7.59,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","TSPAN33","ENSG00000158457","","Amyloid fiber formation","",57.2,57.9,56.5,57.5,46.6,26.1,1.3179723502304146,0.3983201043339099,0.20853669511535092,0.6808175134293255,0.4446308939901108,0.35200036479651314,3428]
["Q86UV5","Ubiquitin carboxyl-terminal hydrolase 48 [OS=Homo sapiens]",15,11,20,11,1035,119,6.05,67.89,"protein metabolism;other metabolic processes","cytosol;mitochondrion;nucleus","other molecular function","USP48","ENSG00000090686","","Ub-specific processing proteases","",1951.6,1873.1,1913.1,2196.3,2182.8,1684.5,0.946269542845834,-0.07967690420048552,0.5574912767111965,0.2537619238059563,0.6892259373278308,0.16163838730875257,5912]
["Q86V42","Protein FAM124A [OS=Homo sapiens]",1,1,1,1,546,60.1,6.6,1.79,"","","","FAM124A","ENSG00000150510","","","",283.8,298,284.2,282.5,293.6,311.3,0.9758846067162498,-0.035217528206136564,0.4986333630959743,0.30221866661898106,0.6464191647514147,0.18948577627059163,5638]
["Q86V85","Integral membrane protein GPR180 [OS=Homo sapiens]",5,2,3,2,440,49.4,7.39,6.67,"signal transduction;other biological processes","other membranes","","GPR180","ENSG00000152749","","","",122.8,131.4,113.3,108.7,99,951.6,0.31700163892003796,-1.6574377956718946,0.4032724779629056,0.39440141616916535,0.5832050932787648,0.2341786918690883,5054]
["Q86VQ1","Glucocorticoid-induced transcript 1 protein [OS=Homo sapiens]",20,8,12,8,547,58,9.44,39.59,"","other cell component","","GLCCI1","ENSG00000106415","","","",1157.2,1183.5,1205.9,1477.9,1567,2213.3,0.6744893689855843,-0.5681323906799375,0.06986490414538561,1.155740932461243,0.2624062612531467,0.5810258065096032,1946]
["Q86VX9","Vacuolar fusion protein MON1 homolog A [OS=Homo sapiens]",12,4,4,4,555,62.1,6.3,15.8,"","","","","","","","",151.4,149,148.2,130,142.8,140.6,1.08514755684567,0.11789123166082485,0.044776282408383175,1.3489519669550054,0.20978836418132862,0.678218603425494,1560]
["Q86W56","Poly(ADP-ribose) glycohydrolase [OS=Homo sapiens]",17,12,21,12,976,111,6.43,67.22,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","PARG","ENSG00000227345","","POLB-Dependent Long Patch Base Excision Repair","",1182.2,1201.7,1159.4,1229.4,1247.5,1182.3,0.9683264101442939,-0.04643465181031908,0.1676921919792803,0.7754871583793448,0.3994987715699347,0.39848455177231523,3068]
["Q86WN1-1","F-BAR and double SH3 domains protein 1 [OS=Homo sapiens]",9,6,7,6,690,76.9,5.34,16.03,"cell-cell signaling;cell organization and biogenesis","cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","FCHSD1","ENSG00000197948","","","",910.2,888.6,897.4,891.6,933.5,1271.5,0.8706968933669187,-0.19975751905088807,0.3298774082160655,0.48164742626448703,0.5413277899980293,0.26653967707853343,4454]
["Q86WU2","Probable D-lactate dehydrogenase, mitochondrial [OS=Homo sapiens]",3,1,1,1,507,54.8,6.65,3.44,"other metabolic processes","other membranes;mitochondrion","other molecular function","LDHD","ENSG00000166816","Pyruvate metabolism; Metabolic pathways","Mitochondrial protein import","Clear cell renal cell carcinoma pathways",46.6,54.3,45.7,50.7,55.8,70.2,0.829654782116582,-0.26941693641780473,0.19451504906228687,0.7110467929404457,0.4290013559433479,0.36754133513979065,3314]
["Q86X95","Corepressor interacting with RBPJ 1 [OS=Homo sapiens]",8,4,5,4,450,52.3,9.86,9.3,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","CIR1","ENSG00000138433","Notch signaling pathway; Epstein-Barr virus infection","","Notch signaling pathway (Netpath)",250.7,275.8,243.6,367,392,259.9,0.7558150947099813,-0.40389476331545676,0.11745287419340517,0.9301363511208349,0.3412015331794906,0.4669890260100933,2516]
["Q86Y07","serine/threonine-protein kinase VRK2 [OS=Homo sapiens]",6,3,5,3,508,58.1,8.84,10.03,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;mitochondrion;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","VRK2","ENSG00000028116","","RAC1 GTPase cycle; RAC3 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOD GTPase cycle","",260.8,265.8,223.4,254.3,270.1,312.7,0.8959503046231034,-0.15850938187023736,0.25704159525846826,0.5899965921180692,0.48520584187607035,0.31407397887045235,3872]
["Q86Y39-1","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [OS=Homo sapiens]",26,2,4,2,141,14.8,8.72,13.78,"cell organization and biogenesis","other membranes;mitochondrion","","NDUFA11","ENSG00000174886; ENSPPAG00000024786; ENSPTRG00000029161","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Nonalcoholic fatty liver disease; Oxidative phosphorylation",262.7,225.8,242,321.1,307.5,217.2,0.8636793568219437,-0.21143228733794098,0.32532634470232236,0.4876807664274092,0.5380878600202024,0.26914680610572955,4419]
["Q86YB8","ERO1-like protein beta [OS=Homo sapiens]",11,5,8,3,467,53.5,7.99,22.85,"other biological processes","other membranes;ER/Golgi","other molecular function","ERO1B","ENSG00000086619","Protein processing in endoplasmic reticulum","Insulin processing","",237.8,257.6,298.4,230.3,251.9,367,0.9347621290626471,-0.09732880890554489,0.7087642356398436,0.14949820513925968,0.8007973099847916,0.09647739439577503,6469]
["Q86YS6","Ras-related protein Rab-43 [OS=Homo sapiens]",39,7,20,6,212,23.3,5.64,58.4,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","RAB43","ENSG00000172780","","Retrograde transport at the Trans-Golgi-Network; RAB geranylgeranylation","",1581.5,1610.5,1726.1,1512.7,1567.4,1057.6,1.1886071972351788,0.24927202187144376,0.19541078348507115,0.7090514739906265,0.4303276337729392,0.36620076451525746,3319]
["Q86YV0","RAS protein activator like-3 [OS=Homo sapiens]",38,35,96,33,1011,111.8,8.75,290.2,"signal transduction;other biological processes","other membranes;cytosol;other cell component","enzyme regulator activity;other molecular function","RASAL3","ENSG00000105122","Ras signaling pathway","Regulation of RAS by GAPs","Ras signaling",10412.2,10502.8,10699,11074.1,10704.5,15522.9,0.8475262388911974,-0.23867006099563928,0.2885555969643371,0.5397704974871742,0.512030312748808,0.2907043275596187,4119]
["Q8IU85-1","calcium/calmodulin-dependent protein kinase type 1D [OS=Homo sapiens]",29,11,29,8,385,42.9,7.21,95.13,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","kinase activity;other molecular function","CAMK1D","ENSCATG00000031901; ENSG00000183049; ENSGGOG00000016547; ENSMMUG00000011956; ENSMNEG00000040028; ENSPPYG00000002093; ENSPTRG00000002296; ENSRBIG00000041279; ENSRROG00000039467","Calcium signaling pathway; Oxytocin signaling pathway; Aldosterone synthesis and secretion; Glioma","","",3548.5,3506.7,3543,3671.2,3658.7,3088,1.0173067508806959,0.024754764000131692,0.7708202438481218,0.11304688810573553,0.8453000993677302,0.07298907997164057,6665]
["Q8IUC8-1","Polypeptide N-acetylgalactosaminyltransferase 13 [OS=Homo sapiens]",3,2,2,1,556,64,6.83,4.33,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","GALNT13","ENSG00000144278; ENSGGOG00000034959; ENSMFAG00000043213; ENSMMUG00000055468; ENSPPAG00000035152; ENSPPYG00000012857; ENSPTRG00000012546","Mucin type O-glycan biosynthesis; Other types of O-glycan biosynthesis; Metabolic pathways","O-linked glycosylation of mucins","",104.8,127.7,143,109.7,130.6,110,1.0719383385669428,0.1002219195995714,0.5556643189777678,0.2551874897875561,0.6875487569677509,0.16269649876136386,5907]
["Q8IUR0","Trafficking protein particle complex subunit 5 [OS=Homo sapiens]",32,5,14,5,188,20.8,9.66,29.55,"transport","cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","TRAPPC5","ENSG00000181029","","RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport","",1160.2,1235.6,1328.5,1397.6,1278.5,743.8,1.0890084505394897,0.12301514919174564,0.6494528214744332,0.18745239211598777,0.7563496928229178,0.12127736514691388,6276]
["Q8IV36","protein HID1 [OS=Homo sapiens]",3,2,2,2,788,88.7,6.06,5.21,"","other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","","HID1","ENSG00000167861","","","",123.3,146.4,148.2,181.7,155,280,0.6776390465380248,-0.5614110876556091,0.16319883064731106,0.7872829573789689,0.3948428511093004,0.4035757207682764,3021]
["Q8IV53-1","DENN domain-containing protein 1C [OS=Homo sapiens]",11,5,11,5,801,87,5.67,41.56,"transport","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","DENND1C","ENSG00000205744","","RAB GEFs exchange GTP for GDP on RABs","",615,612.8,647.3,622.4,643,821.5,0.8985097513057645,-0.15439393385205705,0.3331362133579736,0.47737815504014347,0.5427758768242151,0.26537946240311944,4486]
["Q8IVH4","methylmalonic aciduria type A protein, mitochondrial [OS=Homo sapiens]",10,4,5,4,418,46.5,9.29,14.05,"other metabolic processes","mitochondrion;other cell component","other molecular function","MMAA","ENSG00000151611","","Cobalamin (Cbl, vitamin B12) transport and metabolism; Propionyl-CoA catabolism; Defective MMAA causes MMA, cblA type; Defective MUT causes MMAM","",392.5,422.4,427,393.4,367.8,481.8,0.9991150442477877,-1.2772865295490243E-3,0.9924008061836298,0.003312891597571738,0.9959436348202869,1.7652396678692252E-3,7283]
["Q8IW19","Aprataxin and PNK-like factor [OS=Homo sapiens]",5,2,2,2,511,56.9,5.08,6.3,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","APLF","ENSG00000169621","","","",86.1,82.4,89.5,46.5,67.9,49,1.5789473684210527,0.658963082164933,0.011102513653148438,1.95457868408688,0.10965982742008368,0.9599524419338832,740]
["Q8IW50","Protein FAM219A [OS=Homo sapiens]",9,1,2,1,185,20.4,4.73,6.09,"","","","FAM219A","ENSG00000164970","","","",178.7,190.6,185.1,178.8,195.6,109.2,1.1464019851116625,0.1971130128880901,0.4262194390360617,0.3703667468471229,0.5963319065686399,0.22451195323016748,5224]
["Q8IWD4-1","Coiled-coil domain-containing protein 117 [OS=Homo sapiens]",11,3,3,3,279,30.5,5.07,4.93,"","","","CCDC117; FLJ33814","ENSG00000159873","","","",217,197.7,188.1,258.9,274.9,282.1,0.7388160313763942,-0.43671292356390856,2.8807296811867848E-3,{"$f":"-LOG10(AA4227)","v":2.5404974926660966},0.056147341972784565,{"$f":"-LOG10(AC4227)","v":1.2506707985098424},375]
["Q8IWJ2","GRIP and coiled-coil domain-containing protein 2 [OS=Homo sapiens]",30,44,73,43,1684,195.8,5.14,202.13,"cell organization and biogenesis;transport;other biological processes","cytosol;ER/Golgi;nucleus","other molecular function","GCC2","ENSG00000135968","Salmonella infection","Signaling by ALK fusions and activated point mutants; Retrograde transport at the Trans-Golgi-Network","Deregulation of Rab and Rab effector genes in bladder cancer",6275.2,6284,6478.8,7271.3,7332,7336.7,0.8677301731996354,-0.20468159865176128,1.5633118057975845E-4,3.805954392401822,0.015034534195492824,1.8229100227986406,76]
["Q8IWU5-1","Extracellular sulfatase Sulf-2 [OS=Homo sapiens]",7,5,7,5,870,100.4,9.17,19.82,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","SULF2","ENSG00000196562","","","",460.7,479.4,431.9,518,512.9,668.6,0.8072962636069432,-0.30882988036885956,0.10803782301526593,0.9664241755210793,0.325897007188848,0.48691962777461256,2423]
["Q8IWY9","Codanin-1 [OS=Homo sapiens]",5,3,5,3,1227,134,6.77,18.73,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","","CDAN1","ENSG00000140326","","","",201.9,212.9,198.1,201.2,174.2,1192.8,0.3908302512434639,-1.3553859550379956,0.39585661655467524,0.40246209163832825,0.5788947599836177,0.23740038154478652,4998]
["Q8IWZ8-1","SURP and G-patch domain-containing protein 1 [OS=Homo sapiens]",9,5,9,5,645,72.4,7.61,25.73,"RNA metabolism OR transcription;other metabolic processes","nucleus","","SUGP1","ENSG00000105705","","mRNA Splicing - Major Pathway","mRNA processing",762.8,758.4,738.1,854.1,739.9,941.6,0.8910317084713677,-0.1664513221295829,0.19287120886236256,0.7147325974749404,0.4270510952968822,0.36952015992127896,3301]
["Q8IXH7","Negative elongation factor C/D [OS=Homo sapiens]",25,11,27,11,590,66.2,5.1,83.75,"other biological processes","nucleus","nucleic acid binding activity","NELFCD","ENSG00000101158","","RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat","Initiation of transcription and translation elongation at the HIV-1 LTR",2275.3,2367.2,2411,2418.7,2348.7,1712.3,1.0885534824143093,0.12241229123617776,0.4491809890240249,0.34757863294637403,0.6108025765165764,0.214099139650044,5375]
["Q8IXS8","protein FAM126B [OS=Homo sapiens]",3,2,2,2,530,58.6,7.9,3.57,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol","","FAM126B","ENSG00000155744","","","",139.2,173.6,156,157.7,148.1,108.1,1.1326407344769267,0.1796903211919571,0.3702977748571627,0.4314488976458293,0.5658595936506382,0.24729131663382037,4783]
["Q8IXW5","Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 [OS=Homo sapiens]",14,7,8,7,612,69.5,7.78,26.92,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","RPAP2","ENSG00000122484","","RNA polymerase II transcribes snRNA genes","",705.9,660,660,836.7,786.7,879.1,0.8095504495504496,-0.30480710571425,6.6887938696067895E-3,2.174652187613178,0.0845819972196471,1.072722064149734,578]
["Q8IY63-1","Angiomotin-like protein 1 [OS=Homo sapiens]",1,1,1,1,956,106.5,7.11,0,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","AMOTL1","ENSG00000166025","Tight junction","Signaling by Hippo","",134.8,140.8,132.1,148.7,150.8,161,0.885342019543974,-0.17569319949015044,0.018507217762877847,1.7326588649342445,0.13732919251662354,0.8622371335478833,985]
["Q8IY95","transmembrane protein 192 [OS=Homo sapiens]",12,3,11,3,271,30.9,7.99,29.51,"","other membranes;nucleus;other cytoplasmic organelle;other cell component","other molecular function","TMEM192","ENSG00000170088","","","",1827.6,1715.4,1785,1533.9,1651.9,1091,1.2457912457912457,0.3170623397155462,0.11405613618554379,0.9428813448473536,0.3365507869923858,0.47294938954921767,2477]
["Q8IYD1","eukaryotic peptide chain release factor GTP-binding subunit ERF3B [OS=Homo sapiens]",32,17,60,5,628,68.8,5.43,148.61,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","GSPT2","ENSG00000189369","mRNA surveillance pathway","Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Translation factors",278,310,286.1,296.8,291.9,319.8,0.9621353880022016,-0.055688176093569575,0.4240654711681046,0.3725670878129654,0.5951410385498611,0.22538010148912796,5208]
["Q8IYS1","Peptidase M20 domain-containing protein 2 [OS=Homo sapiens]",51,17,62,16,436,47.7,5.85,200.63,"protein metabolism;other biological processes","nucleus","other molecular function","PM20D2","ENSG00000146281","","","",7379,7644.8,7824.2,7518.8,7594,8671.3,0.9606417732855144,-0.05792954968752529,0.47279503760067443,0.3253270904050458,0.6277309590959727,0.2022264518288434,5505]
["Q8IYU8","calcium uptake protein 2, mitochondrial [OS=Homo sapiens]",12,4,5,4,434,49.6,9.09,13.56,"transport;other biological processes","other membranes;mitochondrion","other molecular function","MICU2","ENSG00000165487","","Processing of SMDT1","",279.4,299.9,287.2,322.9,277.7,225.7,1.0486506111581748,0.06853408162195306,0.664981353355728,0.17719053251381503,0.7680702768136878,0.11459904111946223,6328]
["Q8IZ81","ELMO domain-containing protein 2 [OS=Homo sapiens]",29,8,34,8,293,34.9,8.05,93.22,"stress response;other biological processes","","enzyme regulator activity","ELMOD2","ENSG00000179387","","","Lung fibrosis",3253,3487,3499.2,2962.8,2803.5,1942,1.3283343927973743,0.40961837417181174,0.06134957539463135,1.2121884387137778,0.24449511808034927,0.6117298081638071,1834]
["Q8IZN3-1","Probable palmitoyltransferase ZDHHC14 [OS=Homo sapiens]",2,1,1,1,488,53.4,8.24,1.87,"protein metabolism;other metabolic processes;transport","other membranes;ER/Golgi","other molecular function","ZDHHC14","ENSG00000175048; ENSGGOG00000012728; ENSPPYG00000017128","","","",25.8,23.2,36,34.8,28.9,36.3,0.8499999999999999,-0.2344652536370232,0.3299456800171182,0.4815575534876735,0.5413182884949758,0.2665472999765941,4455]
["Q8IZT6-1","Abnormal spindle-like microcephaly-associated protein [OS=Homo sapiens]",3,8,10,8,3477,409.5,10.45,29.69,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","other molecular function","ASPM","ENSG00000066279","","","",673.3,687.5,664.2,638.8,603.1,725.2,1.0294341924660668,0.04185160730152794,0.6283553529285467,0.20179468083387095,0.7411084838719941,0.13011821509957683,6197]
["Q8N0X7","Spartin [OS=Homo sapiens]",1,1,1,1,666,72.8,5.91,1.7,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;other cell component","other molecular function","SPART","ENSG00000133104","Endocytosis","","",81,81.5,92.8,101.9,97.9,144.9,0.7406440382941688,-0.4331477609601507,0.12743520434662903,0.8947105803094383,0.353347461521059,0.4517980243474376,2636]
["Q8N0Z8","tRNA pseudouridine synthase-like 1 [OS=Homo sapiens]",10,3,5,3,303,33.2,9.85,13.95,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","PUSL1","ENSG00000169972","","","",321.7,346.9,308.1,293.3,273.7,457.8,0.9530640124902421,-0.06935497896746555,0.800805498587507,0.0964729535132356,0.8681529797057386,0.061403739814215715,6742]
["Q8N141","Zinc finger protein 82 homolog [OS=Homo sapiens]",1,1,1,1,532,62.5,8.98,2.89,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZFP82","ENSG00000181007","Herpes simplex virus 1 infection","","",126.1,153.9,153.7,221.5,210.4,70.4,0.86342823014135,-0.2118518318087262,0.6680691625354473,0.1751785744216924,0.7701762632447294,0.11340987041945215,6340]
["Q8N1G4","Leucine-rich repeat-containing protein 47 [OS=Homo sapiens]",42,21,77,21,583,63.4,8.28,235.75,"","","other molecular function","LRRC47","ENSG00000130764","","","",7208.7,7290.7,7560.3,7737.4,7529.8,7690.3,0.9608929543722096,-0.057552374396349554,0.07236090654876796,1.1404960008688674,0.2663070825603953,0.5746172831442569,1986]
["Q8N1S5-1","zinc transporter zip11 [OS=Homo sapiens]",10,2,4,2,342,35.4,5.6,13.38,"transport","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","transporter activity","SLC39A11","ENSG00000133195","Alzheimer disease; Parkinson disease","","Nuclear receptors meta-pathway; NRF2 pathway; Zinc homeostasis",103.7,110.4,102.1,80.8,81.7,137.4,1.0543514504834948,0.07635584548963094,0.7879200634478586,0.1035178405871611,0.858001749663349,0.066511826523832,6712]
["Q8N2K1-1","Ubiquitin-conjugating enzyme E2 J2 [OS=Homo sapiens]",5,1,1,1,259,28.9,8.4,4.48,"protein metabolism;other metabolic processes;stress response","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","UBE2J2","ENSG00000160087","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum; Parkinson disease; Pathways of neurodegeneration","Antigen processing: Ubiquitination & Proteasome degradation; E3 ubiquitin ligases ubiquitinate target proteins","Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway",73,91.6,79.4,128.6,135.8,173.8,{"$f":"AVERAGE(S4354:U4354)/AVERAGE(V4354:X4354)","v":0.5568233683249657},{"$f":"LOG(Y4354,2)","v":-0.844708336539974},{"$f":"TTEST(V4354:X4354,S4354:U4354,2,2)","v":0.012620761467325825},1.898914441361202,{"$f":"AA4354*7309/AE4354","v":0.11603162964111252},0.9354236081336993,795]
["Q8N3C0","Activating signal cointegrator 1 complex subunit 3 [OS=Homo sapiens]",22,36,65,36,2202,251.3,7.09,177.2,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","cytosol;nucleus","other molecular function","ASCC3","ENSG00000112249","","ALKBH3 mediated reversal of alkylation damage","Mesodermal commitment pathway; VEGFA-VEGFR2 signaling pathway",6913.9,6798.4,6819.1,7283.3,6674.8,6988.6,0.9801734879479822,-0.028890970097709974,0.4830361386802846,0.3160203759931949,0.6353268197974088,0.19700281089460103,5557]
["Q8N3F8","MICAL-like protein 1 [OS=Homo sapiens]",8,6,7,6,863,93.4,7.25,21.62,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;other cytoplasmic organelle","other molecular function","MICALL1","ENSG00000100139","","","",739.9,757.3,750.2,846,838.7,786.6,0.9093999109780275,-0.13701323203161347,0.0182631318902413,1.73842474454444,0.13676765469853858,0.8640166003271589,976]
["Q8N3Z6","Zinc finger CCHC domain-containing protein 7 [OS=Homo sapiens]",9,4,4,4,543,63,7.33,7.63,"","cytosol;nucleus","other molecular function","ZCCHC7","ENSG00000147905","RNA degradation","","",99.9,96.8,101.8,96.9,121.3,182.9,0.744203440538519,-0.42623103466234186,0.2529771207167725,0.5969187546967683,0.4826441595716236,0.31637294479587297,3831]
["Q8N488","RING1 and YY1-binding protein [OS=Homo sapiens]",30,5,8,5,228,24.8,9.63,24.08,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RYBP","ENSG00000163602","","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Transcriptional Regulation by E2F6","",748.5,724.6,793.3,544,600.8,385.1,1.4814040133342046,0.5669651507858747,0.022146519713704092,1.6546945126865045,0.1483674725824594,0.8286613013908735,1091]
["Q8N4Q0","Prostaglandin reductase 3 [OS=Homo sapiens]",11,4,9,4,377,40.1,8.18,24.72,"other metabolic processes;other biological processes","other cytoplasmic organelle","other molecular function","ZADH2","ENSG00000180011","","","",722.3,705.7,701.5,654.7,688.5,809.7,0.9891309396627805,-0.015766579466119323,0.8774846845659545,0.05676045488098699,0.919767038504598,0.036322158201932325,6973]
["Q8N554","Zinc finger protein 276 [OS=Homo sapiens]",2,1,1,1,614,67.2,8.51,1.62,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF276","ENSG00000158805","","","",73.8,79.8,77.8,85.2,80.4,81.3,0.937221547185095,-0.09353797203529225,0.08781363010008807,1.0564380693122026,0.2936092508698736,0.5322302650419135,2186]
["Q8N584-1","Tetratricopeptide repeat protein 39C [OS=Homo sapiens]",2,1,1,1,583,65.8,6.99,4.74,"cell organization and biogenesis;developmental processes","","","TTC39C","ENSG00000168234","","","",60.4,45.7,58.1,59.5,54.5,193.7,0.5336366590835229,-0.9060703165557401,0.3554251575367113,0.44925183541453506,0.5555608375611255,0.25526837602036456,4676]
["Q8N5G2-1","macoilin [OS=Homo sapiens]",10,7,10,7,664,76.1,9.07,24.67,"developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","cytoskeletal activity","LOC111154705; MACO1","ENSANAG00000024751; ENSCAFG00000012804; ENSCAFG00040000254; ENSCATG00000033846; ENSCCAG00000030283; ENSCPOG00000012618; ENSCSAG00000000952; ENSG00000204178; ENSMMUG00000018014; ENSMNEG00000031369; ENSPANG00000000594; ENSPPAG00000042632; ENSPPYG00000001709; ENSPTRG00000029594","","RHOC GTPase cycle; RHOA GTPase cycle","",1235.7,1290.5,1253.1,1268.5,1476.8,1496,0.8910711338504703,-0.16638748877768536,0.1079770652942815,0.9666684803822755,0.32584821231870503,0.48698465730533586,2422]
["Q8N5U6-1","RING finger protein 10 [OS=Homo sapiens]",5,3,3,3,811,89.9,6.92,6.95,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RNF10","ENSG00000022840","","","",168.4,163.1,172.3,172.1,184.4,265.3,0.810228369250563,-0.30359949460682273,0.25131801395860576,0.5997763809560442,0.48111141016853054,0.31775434312971923,3818]
["Q8N5X7","Eukaryotic translation initiation factor 4E type 3 [OS=Homo sapiens]",15,3,5,3,224,24.4,6.42,13.8,"protein metabolism;other metabolic processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity","EIF4E3","ENSG00000163412","","ISG15 antiviral mechanism","",737.7,714.7,724.7,743.5,754,869.7,0.9196941534302132,-0.12077392577168361,0.1968930543549963,0.705769603864433,0.4316410720697864,0.36487723747244655,3334]
["Q8N6H7","ADP-ribosylation factor GTPase-activating protein 2 [OS=Homo sapiens]",28,14,36,14,521,56.7,7.99,94.25,"cell organization and biogenesis;transport","plasma membrane;other membranes;cytosol;ER/Golgi","enzyme regulator activity;other molecular function","ARFGAP2","ENSG00000149182","Endocytosis","COPI-dependent Golgi-to-ER retrograde traffic; CDC42 GTPase cycle; COPI-mediated anterograde transport","IL-18 signaling pathway",5189,4948.2,4859.3,6443.8,6159.8,5531.6,0.8269277427323657,-0.27416682323693653,0.0218443676233735,1.6606605232434768,0.14742426866042188,0.8314310179848242,1083]
["Q8N6M3","fat storage-inducing transmembrane protein 2 [OS=Homo sapiens]",5,1,2,1,262,29.8,8.65,6.54,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","FITM2","ENSG00000197296","","Lipid particle organization","",243.5,202.8,209.6,243.9,233.8,112.4,1.111506524317912,0.1525164167171044,0.6449335232017754,0.19048504814692185,0.7532469033368132,0.12306264507312335,6258]
["Q8N806","Putative E3 ubiquitin-protein ligase UBR7 [OS=Homo sapiens]",21,6,15,6,425,48,4.81,48.09,"protein metabolism;other metabolic processes","other cell component","other molecular function","UBR7","ENSG00000012963; ENSG00000278787","","","",1081.2,1172.3,1171.9,1509,1541.6,1218.8,0.8023141425024594,-0.3177608668202355,0.05819973569467814,1.2350789876285215,0.2384427512289252,0.6226158757846528,1784]
["Q8N8Q9","Magnesium transporter NIPA2 [OS=Homo sapiens]",4,1,1,1,360,39.2,8.22,5.24,"transport","plasma membrane;other membranes;other cytoplasmic organelle","transporter activity","NIPA2","ENSG00000140157","","Miscellaneous transport and binding events","Prader-Willi and Angelman syndrome; 15q11.2 copy number variation syndrome",187.2,228.4,220.9,186.5,190.9,41.4,1.5198185291308501,0.6038990718579119,0.2257793622418221,0.6463157580448694,0.45661908096997167,0.3404459443858095,3614]
["Q8N8S7","Protein enabled homolog [OS=Homo sapiens]",12,6,8,6,591,66.5,6.93,18.75,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ENAH","ENSG00000154380","Rap1 signaling pathway; Axon guidance; Regulation of actin cytoskeleton","Generation of second messenger molecules; Signaling by ROBO receptors","Regulation of actin cytoskeleton",866.2,947,917,1041.3,1148.5,876.3,0.890447147842536,-0.16739811164391621,0.2467490784649347,0.6077444606171548,0.4768611883924399,0.3216080232422027,3782]
["Q8N9B5-1","Junction-mediating and -regulatory protein [OS=Homo sapiens]",9,7,7,7,988,111.4,6.18,11.21,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","JMY","ENSG00000152409","","Regulation of TP53 Activity through Methylation","",603.7,590.4,611.4,738.6,730.5,794.9,0.7974823321554771,-0.32647553788324224,0.001949067765730536,2.7101730609484598,0.04748578766574829,1.3234363537841491,300]
["Q8N9Q2","protein SREK1IP1 [OS=Homo sapiens]",5,1,1,1,155,18.2,9.85,0,"RNA metabolism OR transcription;other metabolic processes","","nucleic acid binding activity;other molecular function","SREK1IP1","ENSG00000153006","","","",354.9,394.9,393.4,421.7,376.5,11.6,1.411706594220795,0.4974402734193585,0.44236257923242706,0.3542216184127459,0.6070649815264381,0.2167648186316954,5326]
["Q8N9R8-1","protein SCAI [OS=Homo sapiens]",7,4,6,4,606,70.4,8.6,11.07,"RNA metabolism OR transcription;other metabolic processes;other biological processes","other membranes;nucleus;other cell component","other molecular function","SCAI","ENSANAG00000024288; ENSCSAG00000013617; ENSG00000173611; ENSMMUG00000020633; ENSPPYG00000019606","","RHO GTPases Activate Formins","",549.5,533.6,571,569.2,571.3,1094.3,0.7401557186325398,-0.4340992689225778,0.33077929955650176,0.4804616767787472,0.5413492835778037,0.26652243363019346,4466]
["Q8NB14","Ubiquitin carboxyl-terminal hydrolase 38 [OS=Homo sapiens]",5,5,6,4,1042,116.5,6.21,13.72,"protein metabolism;other metabolic processes","cytosol;nucleus","other molecular function","USP38","ENSG00000170185","","","Integrated breast cancer pathway",319.4,356.5,366.6,264.9,284.5,332.3,1.1823749574685265,0.24168761884689935,0.09513172600506879,1.0216746236392784,0.3061725166759347,0.5140337959750407,2271]
["Q8NB37","Glutamine amidotransferase-like class 1 domain-containing protein 1 [OS=Homo sapiens]",23,4,9,4,220,23.3,6.61,30.33,"","","","GATD1","ENSG00000177225","","","",906.5,874.4,890.3,1166.8,993.1,1689.2,0.6939804110051699,-0.5270331544823198,0.1340298771253887,0.8727983805577487,0.36015601908436246,0.4435093227079745,2720]
["Q8NBB4","Zinc finger and SCAN domain-containing protein 1 [OS=Homo sapiens]",2,1,1,1,408,45.3,8.54,0,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZSCAN1","ENSG00000152467","","","",94.8,116.3,147.5,92.7,96.9,30.2,1.6314831665150138,0.7061841019191438,0.15506969971546503,0.8094730541008636,0.3876212158756272,0.4115924605027135,2924]
["Q8NBJ9-1","SID1 transmembrane family member 2 [OS=Homo sapiens]",5,2,2,2,832,94.4,6.96,5.39,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle","transporter activity;nucleic acid binding activity;other molecular function","SIDT2","ENSG00000149577","","","",35.9,29.3,26.1,34.4,31.3,31.4,0.9402677651905254,-0.08885643543497006,0.5617266466619563,0.25047497398078894,0.6928214749328785,0.1593786592408483,5926]
["Q8NBP0-1","Tetratricopeptide repeat protein 13 [OS=Homo sapiens]",12,8,11,8,860,96.8,7.01,35.48,"","","","TTC13","ENSG00000143643","","","",849.6,824.8,809.5,740.2,713.4,785.3,1.1094287373263658,0.14981700092138384,0.027252859172212842,1.5645879279716945,0.1636739093588362,0.7860205443177867,1217]
["Q8NBS9-1","Thioredoxin domain-containing protein 5 [OS=Homo sapiens]",71,29,1001,28,432,47.6,5.97,2951.38,"transport;other biological processes","non-structural extracellular;ER/Golgi;other cytoplasmic organelle","other molecular function","TXNDC5","ENSG00000239264","Protein processing in endoplasmic reticulum","Golgi Associated Vesicle Biogenesis; Neutrophil degranulation; Lysosome Vesicle Biogenesis","VEGFA-VEGFR2 signaling pathway",109673,102961.6,101844.1,111578.6,111130.9,143654.6,0.8583774993237603,-0.22031583570751584,0.192321100119855,0.7159730654083447,0.4263496878301548,0.3702340506675247,3297]
["Q8NC51-3","Isoform 3 of Plasminogen activator inhibitor 1 RNA-binding protein [OS=Homo sapiens]",46,20,124,3,393,43.1,8.44,368.7,"","","","SERBP1","","","","",15804.6,16648.3,14492.8,15624.2,14111.3,10340.7,1.1714109621171669,0.22824730042917796,0.24725685090742108,0.606851666282576,0.4774637578024678,0.3210595882346946,3785]
["Q8NC56-1","LEM domain-containing protein 2 [OS=Homo sapiens]",29,15,39,15,503,56.9,9,105.47,"cell organization and biogenesis;developmental processes;other biological processes","other membranes;nucleus","nucleic acid binding activity","LEMD2","ENSG00000161904","","Sealing of the nuclear envelope (NE) by ESCRT-III; Initiation of Nuclear Envelope (NE) Reformation; Depolymerisation of the Nuclear Lamina","",3162,3173.8,3236,2833.9,2963.2,4367.1,0.9417170067491784,-0.08663451094953105,0.7083843517452615,0.14973104096833395,0.8006156219121875,0.09657594003147774,6467]
["Q8NCG7","Sn1-specific diacylglycerol lipase beta [OS=Homo sapiens]",17,8,18,8,672,73.7,6.55,51.15,"cell-cell signaling;cell cycle OR cell proliferation;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;nucleus","other molecular function","DAGLB","ENSG00000164535","Retrograde endocannabinoid signaling; Aldosterone synthesis and secretion","Arachidonate production from DAG","Cannabinoid receptor signaling",1326.3,1333.2,1344.7,1325.2,1254.2,1799.3,0.9144723319706762,-0.12898857404682315,0.5062605661001173,0.29562589957759167,0.6519130510263843,0.18581032447905504,5676]
["Q8NCL4","Polypeptide N-acetylgalactosaminyltransferase 6 [OS=Homo sapiens]",4,3,4,2,622,71.1,8.18,13.51,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","GALNT6","ENSG00000139629","Mucin type O-glycan biosynthesis; Other types of O-glycan biosynthesis; Metabolic pathways","O-linked glycosylation of mucins","",183.3,145.3,133.6,194.7,174.3,162.2,0.870105421686747,-0.20073788687929384,0.2647205834738321,0.5772122886134408,0.4920759777747301,0.30796783588956583,3932]
["Q8ND24","Ring finger protein 214 [OS=Homo sapiens]",8,5,7,5,703,77.6,6.95,19.94,"protein metabolism;other metabolic processes","","other molecular function","RNF214","ENSG00000167257","","","",621.1,616.2,581.4,746.3,744.3,635.3,0.855496495601863,-0.22516614991921788,0.057392973896824864,1.241141271096942,0.23699731424400733,0.6252565755747757,1770]
["Q8NDA8-1","Maestro heat-like repeat-containing protein family member 1 [OS=Homo sapiens]",8,15,27,15,1641,181.1,6.89,49.58,"","","","MROH1","ENSG00000179832","","","",2507.9,2521.8,2492.1,2340.3,2354.7,2622.5,1.0279193713700037,0.03972710588721688,0.5009652758293871,0.30019237600565485,0.6481775891373677,0.18830598885800914,5649]
["Q8NDX6","Zinc finger protein 740 [OS=Homo sapiens]",4,1,2,1,193,21.8,9.19,3.54,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF740","ENSG00000139651","","Generic Transcription Pathway","",92.7,106.9,88.6,99,93.1,330.9,0.5510516252390057,-0.8597406109595562,0.3751675706538797,0.42577470892505526,0.56831083397082,0.2454140647208936,4825]
["Q8NE01","Metal transporter CNNM3 [OS=Homo sapiens]",13,8,8,8,707,76.1,6.09,19.59,"transport","plasma membrane;other membranes;other cell component","transporter activity","CNNM3","ENSG00000168763","","","",534.1,537.9,569.2,543.6,521.7,654.3,0.9544080018608979,-0.06732195609076677,0.5720497154780713,0.24256622606790884,0.7014110670070832,0.15402738601341343,5961]
["Q8NEL9-1","Phospholipase DDHD1 [OS=Homo sapiens]",7,5,6,5,900,100.4,5.67,14.26,"other metabolic processes;other biological processes","cytosol;other cell component","other molecular function","DDHD1","ENSG00000100523","","Synthesis of PA","",545.5,561.9,585.1,548.3,555.8,599.5,0.9934843860061047,-0.009430801200616125,0.8599365416725336,0.06553359598700645,0.9081456701465899,0.04184448334378939,6921]
["Q8NEM2","SHC SH2 domain-binding protein 1 [OS=Homo sapiens]",28,14,44,14,672,75.6,4.75,139.46,"signal transduction;other biological processes","cytoskeleton;other cell component","","SHCBP1","ENSG00000171241","","","",2605.3,2713.3,2691.2,3476.2,3515.3,3259.1,0.7813981620588063,-0.3558702327517042,9.7714610933814653E-4,3.0100404928472364,0.0338481559865048,1.4704649862609562,211]
["Q8NEZ2","Vacuolar protein sorting-associated protein 37A [OS=Homo sapiens]",7,2,2,2,397,44.3,5.57,7.15,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","","VPS37A","ENSG00000155975","Endocytosis","Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; HCMV Late Events","7q11.23 copy number variation syndrome",324,279.3,286.6,376.4,363.8,420.9,0.7664283868745155,-0.3837770984731551,0.01513528830188182,1.8200093020464312,0.12542383469212498,0.9016199252942778,882]
["Q8NF37","Lysophosphatidylcholine acyltransferase 1 [OS=Homo sapiens]",32,12,41,12,534,59.1,6.02,121.9,"other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","LPCAT1","ENSG00000153395","Glycerophospholipid metabolism; Ether lipid metabolism; Metabolic pathways","Neutrophil degranulation; Synthesis of PA; Acyl chain remodelling of PC; Acyl chain remodelling of PG; Synthesis of PC","",4338.3,4253.6,4272.8,4152.9,4147,5165.7,0.9553751782319393,-0.06586070050112643,0.5869775549524217,0.23137850513513858,0.7111253023615531,0.14805386856756997,6033]
["Q8NFG4-1","Folliculin [OS=Homo sapiens]",7,3,3,3,579,64.4,6.23,7.92,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","FLCN","ENSG00000154803","mTOR signaling pathway; Renal cell carcinoma","Amino acids regulate mTORC1","Ciliopathies",291.3,294.7,300.7,364.2,320.1,150.7,1.0619161676646707,0.08666987794219327,0.8043991177537413,0.09452841439912953,0.8702417335201443,0.06036009341412762,6756]
["Q8NFT6-1","Protein DBF4 homolog B [OS=Homo sapiens]",1,1,1,1,615,67.2,8.34,0,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","DBF4B","ENSG00000161692","","","",688.1,661.3,670.8,610.3,596.5,1108,0.8727319854847071,-0.19638942222145747,0.5911605098335655,0.22829458498906052,0.7139445086539211,0.14633554245623664,6052]
["Q8NG11-1","Tetraspanin-14 [OS=Homo sapiens]",8,2,2,2,270,30.7,6.84,5.39,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","TSPAN14","ENSCATG00000031568; ENSCSAG00000009464; ENSG00000108219; ENSGGOG00000005770; ENSMMUG00000013895; ENSMNEG00000032257; ENSNLEG00000029109; ENSPPAG00000030989; ENSPTRG00000002686","","Neutrophil degranulation; Amyloid fiber formation","",123.2,118.8,120.6,140.5,135.4,230.6,0.715893385982231,-0.48218334394434265,0.19605745858642643,0.7076166312453742,0.43097262099494454,0.3655503190005247,3325]
["Q8NH93","Olfactory receptor 1L3 [OS=Homo sapiens]",2,1,1,1,324,36.6,9.2,2.06,"signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","OR1L3","ENSG00000171481","Olfactory transduction","","",45.3,49.9,51.4,60.4,44.1,17.7,1.199672667757774,0.26264081831508224,0.5530265225736173,0.2572540398867063,0.6863764397165171,0.16343763232240197,5889]
["Q8NHU6","tudor domain-containing protein 7 [OS=Homo sapiens]",4,5,5,5,1098,123.5,7.21,9.53,"developmental processes;other biological processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","TDRD7","ENSG00000196116","","","",638.9,700,663.2,693,675.6,463.3,1.0929090015830558,0.1281732835073645,0.4965566890705323,0.3040311633919353,0.6449853990432771,0.19045011666195502,5627]
["Q8NHV4","Protein NEDD1 [OS=Homo sapiens]",13,8,15,8,660,71.9,7.97,41.05,"cell cycle OR cell proliferation;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus","","NEDD1","ENSG00000139350","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",1470,1439.4,1464.8,1555.1,1610.2,1315,0.9763185500970917,-0.03457615236193378,0.7176751942396493,0.1440720644838842,0.8069981530303996,0.09312745924276679,6500]
["Q8NI60-1","Atypical kinase COQ8A, mitochondrial [OS=Homo sapiens]",9,6,15,6,647,71.9,6.99,44.09,"protein metabolism;other metabolic processes","other membranes;mitochondrion","kinase activity;other molecular function","COQ8A","ENSG00000163050","","","",1848.7,1879.3,1865.8,1892.7,1876.7,1911.7,0.9846332576437662,-0.022341625040955992,0.09638667478770153,1.0159830020533576,0.308445799484812,0.510821139743195,2284]
["Q8TAF3-1","WD repeat-containing protein 48 [OS=Homo sapiens]",22,11,23,11,677,76.2,7.03,55.85,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","WDR48","ENSANAG00000001805; ENSCAFG00000005066; ENSCANG00000036746; ENSCATG00000045029; ENSCCAG00000035592; ENSCSAG00000014688; ENSFCAG00000025123; ENSG00000114742; ENSGGOG00000002185; ENSLCNG00005009903; ENSMLEG00000040913; ENSMMUG00000020138; ENSMNEG00000033674; ENSNLEG00000005481; ENSPANG00000006231; ENSPPAG00000029758; ENSPTRG00000014765; ENSRROG00000029632; ENSSSCG00070011863; ENSSTOG00000011459","Fanconi anemia pathway","Fanconi Anemia Pathway; Ub-specific processing proteases; Recognition of DNA damage by PCNA-containing replication complex; Ub-specific processing proteases; Fanconi Anemia Pathway; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins; Recognition of DNA damage by PCNA-containing replication complex","DNA repair pathways, full network",1979.2,2064,2075.3,2458.9,2422.6,3523.8,0.727933565726387,-0.4581213048624767,0.10328488228038189,0.9859632411394506,0.3185270905431693,0.4968536252655815,2370]
["Q8TAQ2","SWI/SNF complex subunit SMARCC2 [OS=Homo sapiens]",38,52,186,1,1214,132.8,5.69,556.76,"cell organization and biogenesis;developmental processes;other biological processes","nucleus","other molecular function","SMARCC2","ENSG00000139613","Thermogenesis; Hepatocellular carcinoma","RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","Tumor suppressor activity of SMARCB1; Thermogenesis",21860.7,21311,21325.5,24004,25466.4,19261.1,0.9383936040971025,-0.09173491460793796,0.4948948762386711,0.3054870425169723,0.6446598913613344,0.1906693493364565,5611]
["Q8TB36","ganglioside-induced differentiation-associated protein 1 [OS=Homo sapiens]",10,3,4,3,358,41.3,8.34,12.93,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;mitochondrion;other cytoplasmic organelle","","GDAP1","ENSG00000104381","","Class I peroxisomal membrane protein import","Intracellular trafficking proteins involved in CMT neuropathy",134.8,129.6,129.3,126.8,114.8,241.2,0.8154515327257664,-0.2943289635959803,0.5022491646969887,0.29908077686500983,0.6492640864468147,0.18757861913453763,5654]
["Q8TBQ9","Protein kish-A [OS=Homo sapiens]",13,1,11,1,72,8.1,8.95,25.22,"transport","other membranes;ER/Golgi","","TMEM167A","ENSG00000174695","","","",1420.4,1616.7,1692.4,1177.1,1177.3,359.7,1.7425665966618773,0.8012137934468462,0.07740839777651203,1.1112119216147684,0.27625877897877266,0.5586839120345886,2048]
["Q8TBZ6","tRNA methyltransferase 10 homolog A [OS=Homo sapiens]",8,3,3,3,339,39.7,7.65,5.15,"RNA metabolism OR transcription;other metabolic processes","cytosol;cytoskeleton;mitochondrion;nucleus","nucleic acid binding activity;other molecular function","TRMT10A","ENSG00000145331","","tRNA modification in the nucleus and cytosol","",278.5,298.4,277.6,354.6,400.9,129.6,0.9654276352954467,-0.05075997047374987,0.9092760331477152,0.041304255969650774,0.9432157999257238,0.025388932930901546,7046]
["Q8TCG2","Phosphatidylinositol 4-kinase type 2-beta [OS=Homo sapiens]",11,6,9,5,481,54.7,5.97,19.27,"cell organization and biogenesis;other metabolic processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","kinase activity;other molecular function","PI4K2B","ENSG00000038210","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the ER membrane","",548.2,549,593.3,622.5,657.6,1155.8,0.6939940063220987,-0.5270048918629686,0.2239749638692867,0.6498005247957228,0.45612510752873126,0.34091602124498976,3589]
["Q8TCJ2","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [OS=Homo sapiens]",19,19,81,18,826,93.6,8.91,215.66,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi;other cell component","other molecular function","STT3B","ENSG00000163527","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum","","",11913.9,11811.5,11696.2,9802.7,10199.8,7285.3,1.298074597439149,0.3763732941714775,0.04138673674609475,1.3831388154217747,0.1996671015691132,0.6996934863761257,1515]
["Q8TD16","Protein bicaudal D homolog 2 [OS=Homo sapiens]",42,30,63,27,824,93.5,5.44,201,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","BICD2","ENSG00000185963","","COPI-independent Golgi-to-ER retrograde traffic","",5184.4,5162.4,5274.2,6466.3,6359.7,6190,0.8214661337820782,-0.283726995831029,2.0538829311321011E-4,3.6874243142987604,0.01631720689526579,1.7873541797603427,92]
["Q8TDB6-1","E3 ubiquitin-protein ligase DTX3L [OS=Homo sapiens]",1,1,1,1,740,83.5,8.06,2.45,"protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","DTX3L","ENSG00000163840","Notch signaling pathway","Antigen processing: Ubiquitination & Proteasome degradation","Notch signaling",59.1,60.3,61.3,128.3,117.4,140.9,0.46740817382307287,-1.0972451313466365,5.4823096571861654E-4,3.261036437857232,0.02520138445558093,1.5985756002937108,159]
["Q8TDI8","Transmembrane channel-like protein 1 [OS=Homo sapiens]",1,1,2,1,760,87.7,6.52,3.9,"transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","transporter activity","TMC1","ENSG00000165091","","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea","",302.2,443.4,479.6,314.8,302.2,73.1,{"$f":"AVERAGE(S4674:U4674)/AVERAGE(V4674:X4674)","v":1.7753948703086506},{"$f":"LOG(Y4674,2)","v":0.8281399339579666},{"$f":"TTEST(V4674:X4674,S4674:U4674,2,2)","v":0.13484870526118714},0.8701532190340143,{"$f":"AA4674*7309/AE4674","v":0.3606327064595744},0.44293488884270205,2733]
["Q8TDY2-1","RB1-inducible coiled-coil protein 1 [OS=Homo sapiens]",17,26,40,26,1594,183,5.41,90.54,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RB1CC1","ENSG00000023287","Autophagy; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration","Macroautophagy","Alzheimer's disease and miRNA effects; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Malignant pleural mesothelioma; Alzheimer's disease; Senescence and autophagy in cancer",3373,3396,3421.6,3691.5,3444.4,4135.3,0.9041273333806515,-0.1454021250121495,0.15006681351656884,0.823715339070237,0.38097893018152196,0.41909904206434595,2879]
["Q8TEA8","D-aminoacyl-tRNA deacylase 1 [OS=Homo sapiens]",35,6,23,6,209,23.4,8.24,66.76,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DTD1","ENSG00000125821","","","",2345.7,2551.2,2670.7,2712.2,2318.4,1590.5,1.1429520774493664,0.1927649144224239,0.4084593847655227,0.3888511211368359,0.5867589707647809,0.2315402618932204,5088]
["Q8TED0","U3 small nucleolar RNA-associated protein 15 homolog [OS=Homo sapiens]",21,12,22,12,518,58.4,9.11,54.87,"RNA metabolism OR transcription;other metabolic processes;other biological processes","ER/Golgi;nucleus;other cell component","","UTP15","ENSG00000164338","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",2704.4,2645.5,2673.3,3149.9,3011.4,4193.2,0.7748515138345647,-0.3680082242152047,0.10587666783196292,0.9751997353435208,0.3216344826200403,0.4926373964633738,2406]
["Q8TET4","neutral alpha-glucosidase c [OS=Homo sapiens]",5,2,2,2,914,104.3,6.23,6.3,"protein metabolism;other metabolic processes","","other molecular function","GANC","ENSG00000214013","Galactose metabolism; Starch and sucrose metabolism; Metabolic pathways","","",59.3,47,38.6,50.7,42,50.9,1.0090529247910864,0.01300184573387812,0.951452525085814,0.021612876959351556,0.971116674466166,0.012728588801795575,7161]
["Q8TEU7","Rap guanine nucleotide exchange factor 6 [OS=Homo sapiens]",12,16,23,14,1601,179.3,6.4,67.06,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","RAPGEF6","ENSG00000158987","Rap1 signaling pathway; Tight junction","","",1502.4,1490,1492.6,1735.6,1729.3,4314.7,0.5765077896035786,-0.7945879936078337,0.27106109208934476,0.5669328162578349,0.49791041017366694,0.30284879352025024,3979]
["Q8TF30","WASP homolog-associated protein with actin, membranes and microtubules [OS=Homo sapiens]",3,2,3,2,809,90.9,7.08,12.4,"cell adhesion;cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","WHAMM","ENSG00000156232","Tight junction","RHOD GTPase cycle","",154.8,129,137.9,128,130.1,230.8,0.8625485784413992,-0.2133223837290035,0.5543511034569326,0.2562150836548165,0.6868540795332633,0.1631355179399912,5899]
["Q8WTS6","Histone-lysine N-methyltransferase SETD7 [OS=Homo sapiens]",34,10,22,10,366,40.7,4.63,70.13,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","other molecular function","SETD7","ENSG00000145391","Lysine degradation; Metabolic pathways; FoxO signaling pathway","PKMTs methylate histone lysines","Histone modifications",2180.9,2208,2181.2,2499.9,2585,2431.2,0.8741368528891315,-0.1940689324057327,2.2534112512428888E-3,2.6471595415887763,0.050213972058945955,1.2991754234164823,328]
["Q8WTW4","GATOR complex protein NPRL2 [OS=Homo sapiens]",10,3,4,3,380,43.6,6.52,11.64,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;other cytoplasmic organelle;other cell component","enzyme regulator activity;kinase activity","NPRL2","ENSG00000114388","mTOR signaling pathway","Amino acids regulate mTORC1","22q11.2 copy number variation syndrome",250.5,264,268.6,327.7,343.9,245.6,0.8537941561273443,-0.22803980692696071,0.22166336230971062,0.654306083437709,0.4549670078971286,0.34202009522798976,3561]
["Q8WUA4-1","General transcription factor 3C polypeptide 2 [OS=Homo sapiens]",14,9,12,9,911,100.6,7.31,32.67,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","GTF3C2","ENSG00000115207; ENSPPAG00000042866; ENSPTRG00000011763","","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter","",1435.3,1364,1322.9,1673.2,1636.9,2452.1,0.7153864843289022,-0.48320523288056094,0.110881994033252,0.9551389725784875,0.33092547749654505,0.4802697958192286,2449]
["Q8WUF8","Protein Fam172a [OS=Homo sapiens]",11,4,5,4,416,47.9,6.09,13.07,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","ER/Golgi;nucleus","","FAM172A","ENSG00000113391","","","",214.3,199.2,199.5,233.4,226.8,204.9,0.921665914900015,-0.11768419701031944,0.1558985312615268,0.8071579763314852,0.38770410513456943,0.41149960052012474,2939]
["Q8WUM0","Nuclear pore complex protein Nup133 [OS=Homo sapiens]",39,35,105,35,1156,128.9,5.1,328.44,"cell organization and biogenesis;other metabolic processes;transport;developmental processes","other membranes;cytosol;nucleus;other cell component","other molecular function","NUP133","ENSG00000069248","Nucleocytoplasmic transport; Amyotrophic lateral sclerosis","Separation of Sister Chromatids; Transport of Mature mRNA derived from an Intron-Containing Transcript; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; ISG15 antiviral mechanism; Transcriptional regulation by small RNAs; tRNA processing in the nucleus; Viral Messenger RNA Synthesis; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; HCMV Early Events; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Postmitotic nuclear pore complex (NPC) reformation","Ciliary landscape",9227.5,9816.3,9590.6,8540,8584.7,5453.8,1.2682153375999292,0.342799729792079,0.12700104113526356,0.8961927187491887,0.3532156048925576,0.45196011775295897,2628]
["Q8WUX1-1","Sodium-coupled neutral amino acid transporter 5 [OS=Homo sapiens]",10,5,11,5,472,51.4,8.21,26.74,"transport","plasma membrane;other membranes","transporter activity","SLC38A5","ENSG00000017483","GABAergic synapse","Amino acid transport across the plasma membrane","Neuroinflammation and glutamatergic signaling",1388.9,1381.8,1470.4,1629.2,1621.1,1907.1,0.8223329584674449,-0.2822054427449947,0.035877709447889074,1.445175291544792,0.18571542376389605,0.731152026376604,1412]
["Q8WUY1","Protein THEM6 [OS=Homo sapiens]",26,5,8,5,208,23.9,9.55,20.98,"","non-structural extracellular","","THEM6","ENSG00000130193","","","",1052.7,1090,1167.9,875.1,1031.3,2520.2,0.7478877693941173,-0.41910630430207213,0.5179816511200502,0.28568562434444367,0.6608357284057335,0.17990648471008328,5729]
["Q8WVB3","Hexosaminidase D [OS=Homo sapiens]",14,4,7,4,486,53.8,5.97,9.2,"other metabolic processes","non-structural extracellular;nucleus;other cell component","other molecular function","HEXD","ENSG00000169660","Other glycan degradation; Various types of N-glycan biosynthesis; Metabolic pathways","","",446.1,470.6,501.1,439.9,476.2,855.8,0.8001580224617644,-0.32164315025129836,0.42797198461030067,0.3685846593218153,0.5977541057742571,0.22347743217750757,5233]
["Q8WVM0","Dimethyladenosine transferase 1, mitochondrial [OS=Homo sapiens]",10,3,5,3,346,39.5,9.26,9.47,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","nucleic acid binding activity;other molecular function","TFB1M","ENSG00000029639","","Transcriptional activation of mitochondrial biogenesis; rRNA modification in the mitochondrion","Energy metabolism; Mitochondrial gene expression",581.4,591.4,613.2,600.9,629.5,1067.6,0.7771975630983464,-0.36364671752489036,0.32244492813073444,0.4915444498699433,0.5367228375558046,0.27024992509035806,4391]
["Q8WVP7-1","Limb region 1 protein homolog [OS=Homo sapiens]",4,2,3,2,490,55.1,5.94,7.03,"developmental processes;signal transduction","plasma membrane;other membranes","other molecular function","LMBR1","ENSG00000105983; ENSPPYG00000018221","","","",172.3,174.8,173.5,154.2,152.3,625.6,0.558523763544684,-0.8403094304388848,0.43283001833223234,0.363682626958882,0.600979218083261,0.2211405456808081,5264]
["Q8WW59","SPRY domain-containing protein 4 [OS=Homo sapiens]",27,4,9,4,207,23.1,6.93,24.78,"","nucleus","","SPRYD4","ENSG00000176422","","","",793,786.1,768.7,718.1,629.7,508.7,1.264637759224347,0.33872420087984784,0.05526483424166007,1.2575511282387397,0.23267895937344094,0.6332428871952399,1736]
["Q8WWM7-1","ataxin-2-like protein [OS=Homo sapiens]",32,28,81,27,1075,113.3,8.59,230.61,"cell organization and biogenesis;other biological processes","other membranes;cytosol;nucleus;other cell component","","ATXN2L","ENSG00000168488","Amyotrophic lateral sclerosis; Spinocerebellar ataxia; Pathways of neurodegeneration","","16p11.2 distal deletion syndrome",9966.1,9580.3,9476.4,14436.5,13757.8,15680.9,0.6614853037706953,-0.5962189904055728,1.050748910026738E-3,2.9785010518289434,0.034908744469933764,1.4570657707671766,220]
["Q8WWW0-2","Isoform 2 of Ras association domain-containing protein 5 [OS=Homo sapiens]",20,5,16,5,265,30.3,8.09,42.51,"","","","RASSF5","","","","",1552.8,1615.2,1607.2,1937.3,2150.7,1407,0.8690081892629663,-0.20255832227415266,0.3405205442826902,0.46785668110963224,0.5470032215741061,0.2620101158827717,4550]
["Q8WXB1-1","Protein N-lysine methyltransferase METTL21A [OS=Homo sapiens]",4,1,1,1,218,24.6,6.27,2.67,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","METTL21A","ENSG00000144401","","Protein methylation","",73.7,75.2,77,62.5,73.6,98.9,0.9612765957446808,-0.056976486059277756,0.792987684924125,0.10073355721080293,0.8610826012643632,0.06495518588357593,6731]
["Q8WXE9-1","Stonin-2 [OS=Homo sapiens]",7,4,6,4,905,101.1,5.39,16.32,"transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","STON2","ENSG00000140022","","Cargo recognition for clathrin-mediated endocytosis","",424.8,393.7,424.5,504.1,466.4,581.2,0.8010569053296384,-0.3200233627142965,0.04354730683954668,1.3610386985412877,0.20574483884308128,0.6866710503566821,1547]
["Q8WXX7-1","Autism susceptibility gene 2 protein [OS=Homo sapiens]",1,1,1,1,1259,138.9,9.38,2.35,"cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","AUTS2","ENSG00000158321","","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","",68.5,58.7,58.6,83.8,76.7,669.2,0.22393636254067736,-2.1588392844383635,0.33577040878661857,0.473957580583187,0.5440358939972058,0.2643724457969245,4511]
["Q8WYP5","protein elys [OS=Homo sapiens]",23,37,83,37,2266,252.3,6.6,286.37,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity","AHCTF1","ENSG00000153207","Nucleocytoplasmic transport","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation","Gastric cancer network 2",6792.2,6464.4,6311.3,7453.9,7415.2,9060.2,0.8177380867806412,-0.2902892583325155,0.060371156650096354,1.2191705034252702,0.24284688164862644,0.6146674688493315,1817]
["Q8WZ42","Titin [OS=Homo sapiens]",0,7,16,3,34350,3813.7,6.35,25.83,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus","cytoskeletal activity;kinase activity;other molecular function","TTN","ENSG00000155657","Hypertrophic cardiomyopathy; Dilated cardiomyopathy","Platelet degranulation ; Striated Muscle Contraction","Striated muscle contraction pathway",1530.3,1665.4,1611.5,1534.8,1489.4,794.2,1.2589566310496543,0.33222858548165995,0.246248781026221,0.6086259106573398,0.47602019056351474,0.32237462613590256,3781]
["Q92187-1","CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase [OS=Homo sapiens]",7,2,2,2,359,41.3,9.74,6.59,"protein metabolism;other metabolic processes;developmental processes","other membranes;ER/Golgi","other molecular function","ST8SIA4","ENSANAG00000034757; ENSCCAG00000025138; ENSG00000113532; ENSGGOG00000011260; ENSNLEG00000035472; ENSPPAG00000033695; ENSPPYG00000015661; ENSPTRG00000042921","","Sialic acid metabolism; NCAM1 interactions","Ectoderm differentiation",57.4,75.1,71,91.3,96.3,431.4,0.3287560581583198,-1.604910614948018,0.28634135259694343,0.5431159278855126,0.5099583202073732,0.29246531810529947,4104]
["Q92508","Piezo-type mechanosensitive ion channel component 1 [OS=Homo sapiens]",11,19,33,19,2521,286.6,7.47,120.25,"transport;other biological processes","plasma membrane;other membranes;ER/Golgi","transporter activity","PIEZO1","ENSG00000103335","","","",2227.9,2096.6,2216.5,1730.6,1839.7,2975.8,0.9992209101602482,-1.124427119986966E-3,0.9968152171829647,1.3853407810657233E-3,0.9990021146839831,4.3359246009094457E-4,7293]
["Q92522","Histone H1x [OS=Homo sapiens]",54,15,108,15,213,22.5,10.76,339.77,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity","H1-10","ENSG00000184897","","","",18827.5,18044.3,16499,11792.9,12834.8,16936.8,1.2840476849234321,0.36069877997201427,0.08313012750528613,1.0802415533751693,0.2868735136620096,0.5423095472626626,2118]
["Q92544","Transmembrane 9 superfamily member 4 [OS=Homo sapiens]",20,12,30,12,642,74.5,6.54,95.66,"cell adhesion;cell organization and biogenesis;stress response;transport;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","","TM9SF4","ENSG00000101337","","","",2919.2,2989.8,2818.6,2820.1,2629.9,2889.2,1.0465752110514197,0.06567599311483743,0.23241969444900396,0.6337270740952513,0.4618693710515959,0.33548083711333704,3678]
["Q92551","Inositol hexakisphosphate kinase 1 [OS=Homo sapiens]",7,2,2,2,441,50.2,7.24,4.45,"other metabolic processes;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","IP6K1","ENSG00000176095","Phosphatidylinositol signaling system","Synthesis of pyrophosphates in the cytosol; Synthesis of IPs in the nucleus","",268.3,288.5,242.5,253.9,290.2,124.1,1.1961987428913499,0.25845710656226767,0.44916357800779216,0.34759546726263235,0.6108925552026336,0.214035167475809,5374]
["Q92576-1","PHD finger protein 3 [OS=Homo sapiens]",11,13,21,13,2039,229.3,6.96,77.84,"RNA metabolism OR transcription;other metabolic processes;developmental processes","","other molecular function","PHF3","ENSG00000118482","","","",1311.5,1334.2,1288.4,2066.4,2126.5,3624.3,0.503262037558205,-0.990618319409243,0.06403412564486838,1.193588516181777,0.24974675791800585,0.6025001408495636,1874]
["Q92609-1","TBC1 domain family member 5 [OS=Homo sapiens]",28,15,26,15,795,88.9,6.54,79.85,"other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","TBC1D5","ENSG00000131374","","","",900.6,839.5,836.2,890.1,890.9,900.7,0.9606965730693219,-0.05784725353545784,0.1730328360985216,0.7618714738468537,0.4052217235001904,0.3923072806282135,3121]
["Q92613","protein jade-3 [OS=Homo sapiens]",5,4,4,4,823,93.7,7.18,7.19,"protein metabolism;other metabolic processes","nucleus","other molecular function","JADE3","ENSG00000102221","","HATs acetylate histones","",194.8,191.4,197.4,216.1,211.7,575.8,0.5815065763252292,-0.7821325874912818,0.31043971810420995,0.5080227195981616,0.5290286546103218,0.2765208039532619,4289]
["Q92622-1","Run domain Beclin-1-interacting and cysteine-rich domain-containing protein [OS=Homo sapiens]",7,5,8,5,972,108.6,6.25,16.64,"other metabolic processes;transport;other biological processes","cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RUBCN","ENSG00000145016","Autophagy","","",732.9,755.4,753,813,733.9,1170,0.8249475505171335,-0.2776256979704258,0.3033213233598979,0.5180970578989542,0.5233653334366133,0.28119504745042867,4236]
["Q92696","geranylgeranyl transferase type-2 subunit alpha [OS=Homo sapiens]",30,14,42,14,567,65,5.67,113.42,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","RABGGTA","ENSG00000100949; ENSG00000285193","","RAB geranylgeranylation; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain","",4124.5,4256.7,4264.9,4336.4,4057.9,6456.2,0.8515605535167166,-0.2318189729081991,0.3876174068216005,0.41159672822389415,0.5737334196960466,0.24128985193583463,4938]
["Q92747","Actin-related protein 2/3 complex subunit 1A [OS=Homo sapiens]",19,6,19,5,370,41.5,8.18,61.41,"cell organization and biogenesis","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity","ARPC1A","ENSG00000241685","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection","Clathrin-mediated endocytosis; FCGR3A-mediated phagocytosis; EPHB-mediated forward signaling; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs","Pathogenic Escherichia coli infection",2412.4,2407.2,2357.2,2208.8,2134.5,2058.3,1.1210947263184203,0.16490818306404073,0.005284648131794042,2.2769839240628027,0.07500095766074301,1.124933191220021,515]
["Q92793-1","CREB-binding protein [OS=Homo sapiens]",8,15,27,8,2442,265.2,8.53,70.88,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CREBBP","ENSG00000005339","cAMP signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Cell cycle; Wnt signaling pathway; Notch signaling pathway; TGF-beta signaling pathway; Adherens junction; JAK-STAT signaling pathway; Long-term potentiation; Melanogenesis; Thyroid hormone signaling pathway; Glucagon signaling pathway; Growth hormone synthesis, secretion and action; Huntington disease; Tuberculosis; Hepatitis B; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Pathways in cancer; Viral carcinogenesis; MicroRNAs in cancer; Renal cell carcinoma; Prostate cancer","Heme signaling; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RORA activates gene expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; HATs acetylate histones; SUMOylation of transcription cofactors; Pre-NOTCH Transcription and Translation; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production; Formation of the beta-catenin:TCF transactivating complex; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation; Attenuation phase; CD209 (DC-SIGN) signaling; Activation of the TFAP2 (AP-2) family of transcription factors; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Regulation of gene expression by Hypoxia-inducible Factor; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells","Androgen receptor signaling pathway; Angiogenesis; TNF-alpha signaling pathway; Notch signaling; Initiation of transcription and translation elongation at the HIV-1 LTR; IL-6 signaling pathway; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Wnt signaling pathway and pluripotency; Clear cell renal cell carcinoma pathways; Ebola virus pathway in host; Type 2 papillary renal cell carcinoma; Ciliary landscape; Hepatitis B infection; Male infertility; TGF-beta receptor signaling in skeletal dysplasias; Overlap between signal transduction pathways contributing to LMNA laminopathies; 15q13.3 copy number variation syndrome; TGF-beta receptor signaling; Sudden infant death syndrome (SIDS) susceptibility pathways",1975.3,1957.3,2007.5,2357.5,2433.6,1857.4,0.8934496502970596,-0.1625416653558739,0.26273507902384347,0.5804819385979557,0.48988027872073264,0.3099100437344399,3920]
["Q92797-1","Symplekin [OS=Homo sapiens]",28,34,94,34,1274,141.1,6.13,244.46,"cell adhesion;RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","","SYMPK","ENSG00000125755","mRNA surveillance pathway; Tight junction","mRNA Splicing - Major Pathway; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs","",10972.9,10759.7,10880.1,12437.5,12592.7,13783.1,0.840245482862833,-0.25111721322306124,0.008570611651447804,2.06698818305117,0.09622519287316744,1.0167112097353888,651]
["Q92845","Kinesin-associated protein 3 [OS=Homo sapiens]",10,7,10,6,792,91.1,5.08,27.94,"cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","KIFAP3","ENSG00000075945","","COPI-dependent Golgi-to-ER retrograde traffic; Translocation of SLC2A4 (GLUT4) to the plasma membrane; MHC class II antigen presentation; Kinesins; Intraflagellar transport","Genes related to primary cilium development (based on CRISPR)",347,357,366.1,388.8,370.6,430.5,0.8993192705269349,-0.15309471192312676,0.0979076791989114,1.0091832438156487,0.3097866784696292,0.5089372618238202,2310]
["Q92882","osteoclast-stimulating factor 1 [OS=Homo sapiens]",37,5,15,5,214,23.8,5.68,53.68,"signal transduction;other biological processes","other cell component","other molecular function","OSTF1","ENSG00000134996","","Neutrophil degranulation","",1257,1142.9,1251.5,1365.7,1370.2,1973.4,0.7753593952392076,-0.36706291025080834,0.16085316166344799,0.7935703983647808,0.39254616313794366,0.4061092632061381,2995]
["Q92890-1","Isoform Long of Ubiquitin recognition factor in ER-associated degradation protein 1 [OS=Homo sapiens]",37,13,34,13,343,38.7,6.34,102.54,"","","","UFD1","","","","",4447.8,4426.8,4441.5,4680.2,4671.1,5170.7,0.9169604737639443,-0.1250685481267509,0.07168024537226445,1.144600516688034,0.2651371019361745,0.5765294950556704,1976]
["Q92918","mitogen-activated protein kinase kinase kinase kinase 1 [OS=Homo sapiens]",23,14,25,14,833,91.2,8.34,62.26,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes","","kinase activity;other molecular function","MAP4K1","ENSG00000104814; ENSG00000282928","MAPK signaling pathway","","B cell receptor signaling pathway; Cardiac hypertrophic response; Hepatocyte growth factor receptor signaling; TGF-beta signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; EGF/EGFR signaling pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Insulin signaling; Modulators of TCR signaling and T cell activation; Malignant pleural mesothelioma; T-cell receptor (TCR) signaling pathway",1705.2,1637.5,1671.2,1601.1,1634,2020.1,0.954083574364439,-0.06781244811138487,0.5858614302122979,0.23220509253240262,0.7108335314445028,0.14823209384107383,6024]
["Q92963","GTP-binding protein Rit1 [OS=Homo sapiens]",17,2,3,2,219,25.1,9.1,10.42,"signal transduction","plasma membrane;other membranes","other molecular function","RIT1","ENSG00000143622","","Signalling to p38 via RIT and RIN","Ectoderm differentiation; Ectoderm differentiation",113.5,96.4,104.6,111.9,101.5,135.3,0.9019214224261541,-0.1489263470100532,0.36430714553247096,0.4385323104081296,0.561281814227831,0.25081902888036284,4744]
["Q92966","snRNA-activating protein complex subunit 3 [OS=Homo sapiens]",11,2,2,2,411,46.7,5.27,3.54,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SNAPC3","ENSG00000164975","","RNA polymerase II transcribes snRNA genes; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter","",11.2,15.9,17.3,15.9,16.3,317.4,0.12700228832951949,-2.977073603150492,0.36845241391507316,0.43361859385265167,0.5644558149874805,0.24837004852760483,4771]
["Q92997","segment polarity protein dishevelled homolog DVL-3 [OS=Homo sapiens]",11,6,9,4,716,78,6.65,16.05,"cell-cell signaling;developmental processes;signal transduction;other biological processes","cytosol;other cell component","signal transduction activity or receptor binding;other molecular function","DVL3","ENSG00000161202","mTOR signaling pathway; Wnt signaling pathway; Notch signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer","WNT mediated activation of DVL; Degradation of DVL; RHO GTPases Activate Formins; PCP/CE pathway; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Negative regulation of TCF-dependent signaling by DVL-interacting proteins; WNT5:FZD7-mediated leishmania damping","Alzheimer's disease and miRNA effects; Neural crest differentiation; Notch signaling; Wnt signaling pathway; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Ciliary landscape; Joubert syndrome; Malignant pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)",754.9,761.9,752.1,795.1,785.1,2214,0.5979916714986032,-0.7418027033926365,0.34442100767892403,0.46291036697219284,0.5488060050414771,0.2605811452202025,4587]
["Q93034","Cullin-5 [OS=Homo sapiens]",22,18,47,18,780,90.9,7.94,120.07,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;transport;signal transduction","cytosol;other cell component","transporter activity;other molecular function","CUL5","ENSG00000166266","Ubiquitin mediated proteolysis; Human immunodeficiency virus 1 infection","Antigen processing: Ubiquitination & Proteasome degradation; Vif-mediated degradation of APOBEC3G; Neddylation; Inactivation of CSF3 (G-CSF) signaling; Downregulation of ERBB2 signaling","Apoptosis-related network due to altered Notch3 in ovarian cancer; Dual hijack model of Vif in HIV infection; Modulators of TCR signaling and T cell activation",4657.7,4777.7,4760,4815.3,4629,3492.8,1.0972629105440943,0.1339092452427706,0.3693247288286531,0.4325916123753545,0.565081524598833,0.2478888917747354,4777]
["Q93086-1","Isoform 2 of P2X purinoceptor 5 [OS=Homo sapiens]",6,2,2,2,421,47.1,7.28,7.62,"","","","P2RX5","","","","",297.4,337.3,354.3,349.1,274.4,254.6,1.126295410545496,0.1715852745165666,0.32983721282614714,0.48170034804461526,0.5415049839502043,0.266397541823313,4452]
["Q969F2-1","protein naked cuticle homolog 2 [OS=Homo sapiens]",3,1,1,1,451,50,7.96,4.31,"cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","NKD2","ENSG00000145506; ENSG00000276920","Wnt signaling pathway; Hippo signaling pathway","","Wnt signaling pathway and pluripotency; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma",23.1,20.4,17,20.4,21.2,81,0.49347471451876024,-1.0189519315288245,0.3622447096077493,0.4409979484515125,0.5599929320057191,0.2518174544407385,4728]
["Q969H4","Connector enhancer of kinase suppressor of Ras 1 [OS=Homo sapiens]",8,3,3,3,720,79.7,5.38,10.8,"signal transduction","plasma membrane;other membranes;other cell component","other molecular function","CNKSR1","ENSG00000142675","","Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants","",69.8,57.6,68.4,82.3,79.1,88.5,0.7835134053621449,-0.3519701364830088,0.019034721574354374,1.720453471337445,0.13898579419276336,0.8570295869327907,1001]
["Q969M1","Mitochondrial import receptor subunit TOM40B [OS=Homo sapiens]",5,2,6,2,308,33.9,7.24,24.12,"cell organization and biogenesis;transport","other membranes;mitochondrion;other cell component","transporter activity;other molecular function","TOMM40L","ENSG00000158882","Amyotrophic lateral sclerosis; Pathways of neurodegeneration","","",398.9,411.4,424.9,336.9,377.6,679.3,0.8862103601664514,-0.17427890226188344,0.6508525087790813,0.18651741677836808,0.7572558081289884,0.12075738695688108,6282]
["Q969R5-1","Lethal(3)malignant brain tumor-like protein 2 [OS=Homo sapiens]",2,1,1,1,705,79.1,6.84,4.57,"cell organization and biogenesis;other biological processes","nucleus","other molecular function","L3MBTL2","ENSG00000100395","","SUMOylation of chromatin organization proteins; Transcriptional Regulation by E2F6","",99.1,89,86.6,135.2,130.1,288.8,0.49575888828731285,-1.012289456627738,0.14902790933620053,0.8267323910799332,0.37952787084957823,0.42075632592995266,2870]
["Q969S9","Ribosome-releasing factor 2, mitochondrial [OS=Homo sapiens]",15,12,19,11,779,86.5,6.51,52.92,"cell organization and biogenesis;protein metabolism;other metabolic processes","mitochondrion","other molecular function","GFM2","ENSG00000164347","","Mitochondrial translation termination","",2964,2799,2848.5,2776.4,2718.5,2843.1,1.0328016310865915,0.04656318418403744,0.20758687532191744,0.6828001082197968,0.4435113919111063,0.3530952205208864,3421]
["Q969V6","MKL/myocardin-like protein 1 [OS=Homo sapiens]",2,2,3,1,931,98.9,5.86,5.08,"cell organization and biogenesis;stress response;other biological processes","cytosol;nucleus;other cell component","cytoskeletal activity;other molecular function","MRTFA","ENSG00000196588","","RHO GTPases Activate Formins; SUMOylation of transcription cofactors","",45.6,47.6,37.8,47.7,47.3,138.9,0.5600684053014108,-0.8363250499276151,0.3252544007299246,0.48777681867170103,0.538090632624495,0.2691445683231442,4418]
["Q969X6","U3 small nucleolar RNA-associated protein 4 homolog [OS=Homo sapiens]",8,6,11,6,686,76.8,8.85,25.28,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","UTP4","ENSG00000141076; ENSG00000262788","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",1074.5,1122.9,1093.6,1154.1,1180.9,1315.6,{"$f":"AVERAGE(S4994:U4994)/AVERAGE(V4994:X4994)","v":0.9014956445515806},{"$f":"LOG(Y4994,2)","v":-0.1496075733894954},{"$f":"TTEST(V4994:X4994,S4994:U4994,2,2)","v":0.08212574897414344},1.0855206567155193,{"$f":"AA4994*7309/AE4994","v":0.2848870902952133},0.5453272304396465,2107]
["Q96A26","Protein FAM162A [OS=Homo sapiens]",12,2,6,2,154,17.3,9.77,21.68,"stress response;other biological processes","other membranes;cytosol;mitochondrion","","FAM162A","ENSG00000114023","","","",478,461.9,480.2,637.5,644.6,379.6,0.8546067280495877,-0.2266674199399892,0.40879666771000106,0.3884926529933461,0.5867821768052628,0.2315230860909909,5092]
["Q96AA3","Protein RFT1 homolog [OS=Homo sapiens]",5,3,6,3,541,60.3,8.85,12.36,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport","other membranes;ER/Golgi","transporter activity","RFT1","ENSG00000163933","","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective RFT1 causes CDG-1n","",583.1,579,600.9,544.3,554.9,433.3,1.1504078303425775,0.20214540074203788,0.12339166731946899,0.9087141673640573,0.3486160403703127,0.4576526341966277,2587]
["Q96AC1","Fermitin family homolog 2 [OS=Homo sapiens]",3,2,2,2,680,77.8,6.7,1.98,"cell adhesion;cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","FERMT2","ENSG00000073712","","RAC1 GTPase cycle; RAC3 GTPase cycle; Cell-extracellular matrix interactions","",97.5,121.3,101.1,106.7,88.4,124,1.0025070510811656,3.6123838363614725E-3,0.9842146616233731,0.006910169667006972,0.9903118064159189,0.004228043296062673,7264]
["Q96AJ9-1","Isoform 1 of Vesicle transport through interaction with t-SNAREs homolog 1A [OS=Homo sapiens]",34,7,13,6,203,23.4,6.15,32.44,"","","","VTI1A","","","","",1536.6,1586.4,1601.1,1518.5,1449.6,1486.4,1.0605230665619039,0.08477600007880758,0.03216756313907138,1.4925818379273714,0.17825073463493005,0.7489686715897638,1319]
["Q96AY2","crossover junction endonuclease EME1 [OS=Homo sapiens]",4,1,1,1,570,63.2,7.05,0,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","EME1","ENSG00000154920","Homologous recombination; Fanconi anemia pathway","Fanconi Anemia Pathway; Resolution of D-loop Structures through Holliday Junction Intermediates","",19,12.7,10,17.9,18.2,4.9,1.0170731707317076,0.024423473939217906,0.9659108292290829,0.015062964848759589,0.9805336459493565,0.008537499396055068,7200]
["Q96AZ6-1","Interferon-stimulated gene 20 kDa protein [OS=Homo sapiens]",38,6,28,6,181,20.4,8.92,94.24,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ISG20","ENSG00000172183; ENSGGOG00000010365; ENSPTRG00000044668","","Interferon alpha/beta signaling","",2213.7,2168.5,2333.5,3119.9,2690.3,2242.1,0.8340101585882294,-0.26186313848888143,0.15945730763305563,0.7973555730532632,0.3909672799362642,0.40785958720192106,2981]
["Q96BD0","solute carrier organic anion transporter family member 4A1 [OS=Homo sapiens]",7,5,8,5,722,77.1,7.83,22.06,"transport","plasma membrane;other membranes","transporter activity","SLCO4A1","ENSG00000101187","","Transport of organic anions","",863,856.6,829.8,873.2,829.8,1424.6,0.8151298119964189,-0.2948982635064768,0.37162347488154157,0.42989686009952477,0.5662280545985381,0.247008616681449,4797]
["Q96BI3-1","gamma-secretase subunit APH-1A [OS=Homo sapiens]",5,2,3,2,265,29,7.9,9.98,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle","enzyme regulator activity;other molecular function","APH1A","ENSANAG00000030676; ENSCANG00000034955; ENSCATG00000033983; ENSCCAG00000036376; ENSCSAG00000018098; ENSG00000117362; ENSGGOG00000017118; ENSMLEG00000037901; ENSMNEG00000034177; ENSNLEG00000009799; ENSPANG00000008739; ENSPPAG00000033416; ENSPPYG00000000905; ENSPTRG00000001250; ENSRBIG00000035934; ENSRROG00000045010; ENSSBOG00000025150","Notch signaling pathway; Alzheimer disease","Amyloid fiber formation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; EPH-ephrin mediated repulsion of cells; NOTCH2 Activation and Transmission of Signal to the Nucleus; Activated NOTCH1 Transmits Signal to the Nucleus; Nuclear signaling by ERBB4; NOTCH4 Activation and Transmission of Signal to the Nucleus; NRIF signals cell death from the nucleus; Regulated proteolysis of p75NTR; Noncanonical activation of NOTCH3","Alzheimer's disease and miRNA effects; Notch signaling; Alzheimer's disease; Notch signaling pathway (Netpath); Notch signaling pathway; Delta-Notch signaling pathway",499.1,447.5,459.2,556.3,523,475.5,0.9041677386158992,-0.14533765275490548,0.15267758218483396,0.8162247261928047,0.3840056600787858,0.41566237427083447,2906]
["Q96BR5","Cytochrome c oxidase assembly factor 7 [OS=Homo sapiens]",39,8,16,8,231,25.7,6.02,41.77,"","mitochondrion;nucleus","","COA7","ENSG00000162377","Thermogenesis","","",1936,1825.8,1764.1,2468.3,2416.3,1953.5,0.8081045904564133,-0.30738606630680054,0.06295071205767927,1.2009993530704646,0.2477688499890026,0.605953294926272,1857]
["Q96BY9","Store-operated calcium entry-associated regulatory factor [OS=Homo sapiens]",5,1,1,1,339,37,7.58,2.79,"transport;other biological processes","other membranes;ER/Golgi;other cell component","","SARAF","ENSG00000133872","","","",92.6,91.4,79.2,96.1,99.2,189.2,0.6845253576072823,-0.5468241091139472,0.2598828595626082,{"$f":"-LOG10(AA5059)","v":0.5852223632187017},0.48742207352915146,{"$f":"-LOG10(AC5059)","v":0.31209480712741905},3897]
["Q96C01","Protein FAM136A [OS=Homo sapiens]",54,7,9,7,138,15.6,7.61,27.53,"","other cell component","","FAM136A","ENSG00000035141","","","",714.4,732,716.6,1009.1,1089.2,838.8,0.736440706819652,-0.4413587209103957,0.02523404242191532,1.5980131711668228,0.15723411428966674,0.8034532213983792,1173]
["Q96C92-4","Isoform 4 of Serologically defined colon cancer antigen 3 [OS=Homo sapiens]",6,1,1,1,362,40,4.88,2.97,"","","","ENTR1","","","","",19.3,16.4,15.9,18.1,23.8,34.3,0.6771653543307086,-0.5624199320700681,0.16692740544801576,0.7774723568031946,0.39871647268612653,0.39933582140080165,3060]
["Q96CM4","Nucleoredoxin-like protein 1 [OS=Homo sapiens]",4,1,3,1,212,23.9,4.84,6.94,"other biological processes","other cell component","","NXNL1","ENSG00000171773","","","",659.2,658.6,691.6,582,612.8,584.8,1.1291301416048554,0.17521177825208561,0.006437992162574908,2.1912495563476004,0.08212091573518325,1.0855462164310172,573]
["Q96CM8","Acyl-CoA synthetase family member 2, mitochondrial [OS=Homo sapiens]",19,10,15,10,615,68.1,7.55,41.94,"other metabolic processes","mitochondrion","other molecular function","ACSF2","ENSG00000167107","","Mitochondrial Fatty Acid Beta-Oxidation","Mitochondrial long chain fatty acid beta-oxidation",1368.8,1168.9,1149.9,1234.5,1116.5,1513.5,0.9542243498512097,-0.0675995934725354,0.6889733326548804,0.16179758753354326,0.7871980754063655,0.10391597636713297,6397]
["Q96CV9-2","Isoform 2 of Optineurin [OS=Homo sapiens]",41,23,58,1,571,65.2,5.17,167.77,"","","","","","","","",96.6,109.1,88.4,94.5,91.1,97.3,1.0395899611170025,0.05601460749081137,0.5841670943546846,0.23346291011951995,0.710192497112174,0.14862392015041748,6012]
["Q96CW6","Probable RNA polymerase II nuclear localization protein SLC7A6OS [OS=Homo sapiens]",42,7,11,7,309,35,4.6,35.29,"transport;developmental processes;other biological processes","nucleus;other cell component","","SLC7A6OS","ENSG00000103061","","","",406.8,424.2,429.3,445.7,471.8,540.2,0.8645811895451738,-0.20992664663076835,0.0857335709353675,1.0668490868620035,0.29131876799934964,0.5356315353654931,2151]
["Q96D71","RalBP1-associated Eps domain-containing protein 1 [OS=Homo sapiens]",19,9,15,9,796,86.6,5.69,50,"transport","plasma membrane;other membranes;cytosol","other molecular function","REPS1","ENSG00000135597","","Cargo recognition for clathrin-mediated endocytosis","",1120.9,1149.2,1192.6,1216.3,1242,1006.1,0.9995092945387369,-7.0811208694793442E-4,0.9945214115804597,0.002385862281988117,0.9976608560584107,1.0170673039122244E-3,7286]
["Q96DI7","U5 small nuclear ribonucleoprotein 40 kDa protein [OS=Homo sapiens]",35,10,29,10,357,39.3,8.1,88.99,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","","SNRNP40","ENSG00000060688","Spliceosome","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","mRNA processing",3389.8,3623.7,3593.4,3716.6,3518.5,2539.9,1.0851048593350383,0.11783446454341909,0.49643004544926295,0.30414194156101193,0.6449355140754822,0.19048370750622107,5626]
["Q96DP5","Methionyl-tRNA formyltransferase, mitochondrial [OS=Homo sapiens]",7,3,7,3,389,43.8,9.66,12.69,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion","other molecular function","MTFMT","ENSG00000103707","One carbon pool by folate; Aminoacyl-tRNA biosynthesis; Metabolic pathways","Mitochondrial translation initiation","One-carbon metabolism",260.7,320.5,279.2,249.7,254.4,202.6,1.2174897410499503,0.28390961575836227,0.10174723885869988,0.9924773675052097,0.3161864663342846,0.5000567230253377,2352]
["Q96E11","Ribosome-recycling factor, mitochondrial [OS=Homo sapiens]",27,5,18,5,262,29.3,9.79,55.07,"cell organization and biogenesis;protein metabolism;other metabolic processes","mitochondrion","translation activity","MRRF","ENSG00000148187","","Mitochondrial translation termination","",1502.9,1665,1851.7,1519,1811.9,1246.7,1.096557147850402,0.1329810010420083,0.485233922926752,0.31404884501711533,0.6367279609823394,0.19604607830687126,5570]
["Q96ED9-2","Isoform 2 of Protein Hook homolog 2 [OS=Homo sapiens]",16,10,11,10,717,83,5.47,26.51,"","","","HOOK2","","","","",727.6,695.4,687.3,917.4,973.5,1729,0.5829719053012514,-0.7785017364345053,0.1271543582468068,0.8956687496833086,0.3531045609520938,0.4520966727412534,2632]
["Q96EE3","nucleoporin Seh1 [OS=Homo sapiens]",29,9,23,9,360,39.6,8.09,84.51,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","SEH1L","ENSG00000085415","Nucleocytoplasmic transport; mTOR signaling pathway; Amyotrophic lateral sclerosis","Amino acids regulate mTORC1","",2773.8,2734.5,2476.3,3056.7,2473.5,1927.1,1.0707092379279364,0.09856675464328277,0.6317050885232116,0.19948562475411843,0.7434995961378669,0.1287192630467257,6210]
["Q96EP0-1","E3 ubiquitin-protein ligase RNF31 [OS=Homo sapiens]",11,9,15,9,1072,119.6,6.57,36.21,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","RNF31","ENSG00000092098; ENSG00000285152","Necroptosis; NOD-like receptor signaling pathway; Shigellosis","Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway","Regulation of toll-like receptor signaling pathway",1029.5,1057.4,1027.4,1041.2,1028.9,1726.4,0.8203081785855393,-0.285762082485812,0.38004909889866856,0.4201602928481735,0.569683934341749,0.2443660279105449,4876]
["Q96ES6","Major facilitator superfamily domain-containing protein 3 [OS=Homo sapiens]",2,1,1,1,412,42.7,9.17,2.16,"transport","other membranes","transporter activity","MFSD3","ENSG00000167700","","","",53.3,46.6,51.2,40.9,54.3,90.4,0.814116379310345,-0.29669304996274276,0.4836649901584129,0.3154553476565896,0.6355820591635815,0.19682837030075734,5562]
["Q96EX1","small integral membrane protein 12 [OS=Homo sapiens]",12,1,2,1,92,10.8,8.44,6.31,"","other membranes","","SMIM12","ENSG00000163866","","","",99.6,94.5,105.4,121,119.9,143.6,0.7789336801040312,-0.3604275951730409,0.027349801184028764,1.5630458263686877,0.16398662580317164,0.7851915701030968,1219]
["Q96F10","Diamine acetyltransferase 2 [OS=Homo sapiens]",13,3,6,3,170,19.1,6.04,4.77,"other metabolic processes","other cell component","other molecular function","SAT2","ENSG00000141504","Arginine and proline metabolism; Metabolic pathways; Ferroptosis","","Ferroptosis",628.6,641.9,611.2,648.7,568.8,674.9,0.9943458042697103,-0.008180428869109307,0.9194377469453003,0.03647767052965103,0.9501160034530185,0.022223366728125204,7073]
["Q96FF9","Sororin [OS=Homo sapiens]",6,1,1,1,252,27.6,9.61,2.45,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","CDCA5","ENSG00000146670","MicroRNAs in cancer","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion","",56.9,65.9,50.8,55,48.7,42.3,1.1890410958904112,0.24979857867710004,0.18280417413856642,0.738013891837148,0.41636513205945214,0.38052564704867914,3209]
["Q96FL9","Polypeptide N-acetylgalactosaminyltransferase 14 [OS=Homo sapiens]",3,1,1,1,552,64.3,7.72,3.54,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","GALNT14","ENSG00000158089","Mucin type O-glycan biosynthesis; Other types of O-glycan biosynthesis; Metabolic pathways","O-linked glycosylation of mucins","",49.4,50,56.6,49.5,59,67.5,0.8863636363636364,-0.17402939977504894,0.30618152936061327,0.5140210120006434,0.5253241310086202,0.2795726492193894,4260]
["Q96G01","Protein bicaudal D homolog 1 [OS=Homo sapiens]",11,9,13,6,975,110.7,5.81,36.9,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","BICD1","ENSG00000151746","","COPI-independent Golgi-to-ER retrograde traffic","",506.6,491.2,526.1,632.6,634,860.6,0.7163877397517865,-0.4811874476118567,0.058131294246021065,1.2355900077222983,0.23842964626496518,0.6226397455391813,1782]
["Q96G03","Phosphoglucomutase-2 [OS=Homo sapiens]",35,23,61,22,612,68.2,6.73,151.91,"other metabolic processes","non-structural extracellular;cytosol;other cell component","other molecular function","PGM2","ENSG00000169299","Glycolysis / Gluconeogenesis; Pentose phosphate pathway; Galactose metabolism; Purine metabolism; Starch and sucrose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars","Neutrophil degranulation; Glycogen breakdown (glycogenolysis); Glycogen synthesis; Pentose phosphate pathway; Galactose catabolism","Clear cell renal cell carcinoma pathways; Glucuronidation",6915.6,7435,7361,6750.5,6653,5366.7,1.1567058422392942,0.21002202442870904,0.10767583442583811,0.9678817540196655,0.3256113669087508,0.4873004425433429,2417]
["Q96GA7","serine dehydratase-like [OS=Homo sapiens]",20,4,11,4,329,34.7,6.89,56.45,"other metabolic processes","cytosol","other molecular function","SDSL","ENSG00000139410","Glycine, serine and threonine metabolism; Cysteine and methionine metabolism; Valine, leucine and isoleucine biosynthesis; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids","Threonine catabolism","Clear cell renal cell carcinoma pathways",720.9,689.5,686.9,660.8,862.7,1307.7,0.7407812941508902,-0.43288042606306915,0.27033640765267236,0.5680954615972882,0.4970789442851276,0.3035746327058043,3975]
["Q96GD0","Pyridoxal phosphate phosphatase [OS=Homo sapiens]",36,8,19,8,296,31.7,6.55,69.41,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","PDXP","ENSG00000241360","Vitamin B6 metabolism; Metabolic pathways; Biosynthesis of cofactors","","",1699.6,1948,1960.4,1737.1,1658.7,1715.5,1.0971768434644806,0.13379607872837504,0.13339195655618566,0.8748703572903952,0.3594991926508706,0.4443020806014479,2712]
["Q96GM1-2","Isoform 2 of Phospholipid phosphatase-related protein type 2 [OS=Homo sapiens]",2,1,2,1,427,45.5,9.52,0,"","","","PLPPR2","","","","",63.2,82.5,82.6,91.4,97,71.1,0.8797687861271676,-0.18480367902054162,0.3644622801139485,0.4383474121636788,0.561284198346576,0.250817184161026,4746]
["Q96GY0","Zinc finger C2HC domain-containing protein 1A [OS=Homo sapiens]",7,2,3,2,325,35.1,9.82,8.43,"","","other molecular function","ZC2HC1A","ENSG00000104427","","","",65.5,71.5,59.5,76,75.8,75.4,0.8648767605633803,-0.20943352235871332,0.04195738903529039,1.377191545331832,0.20148919609654237,0.6957482358824131,1522]
["Q96HA7","Tonsoku-like protein [OS=Homo sapiens]",15,17,36,17,1378,150.8,6.42,111.68,"DNA metabolism;other metabolic processes;stress response","nucleus;other cell component","other molecular function","TONSL","ENSG00000160949","","","",1661.8,1648.3,1707.5,1758,1805,2267.3,0.8606075159082723,-0.21657265511677506,0.17285348417297555,0.7623218620466714,0.40532117928144956,0.39220070243953836,3117]
["Q96HE7","ERO1-like protein alpha [OS=Homo sapiens]",47,15,84,13,468,54.4,5.68,301.52,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","ERO1A","ENSG00000197930","Protein processing in endoplasmic reticulum; Vibrio cholerae infection; Lipid and atherosclerosis","Insulin processing; Detoxification of Reactive Oxygen Species","",8974.9,8987.8,8893.4,8106.4,8491.4,6666.4,1.1543960247934595,0.20713823697515407,0.09768556520946999,1.0101696063224406,0.30975435840174237,0.5089825741641345,2305]
["Q96HY7","Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial [OS=Homo sapiens]",10,7,11,7,919,103,6.93,32.57,"other metabolic processes;developmental processes","mitochondrion","other molecular function","DHTKD1","ENSG00000181192","Lysine degradation; Tryptophan metabolism; Metabolic pathways","Glyoxylate metabolism and glycine degradation","Integrated breast cancer pathway",722.6,756.2,682.2,664.1,649,558.4,1.154688752337697,0.20750402395954543,0.07018198583760991,1.1537743473472548,0.26278695414297687,0.580396198793955,1952]
["Q96I15-1","selenocysteine lyase [OS=Homo sapiens]",20,7,12,7,445,48.1,7.12,36.49,"other metabolic processes","cytosol;ER/Golgi;other cell component","other molecular function","SCLY","ENSG00000132330","Selenocompound metabolism; Metabolic pathways","Metabolism of ingested SeMet, Sec, MeSec into H2Se","",1425.2,1474.1,1523.5,1424.6,1481.6,3511.3,0.6891780288274251,-0.5370513860798356,0.3878414974117169,0.41134572508520617,0.5734844233425529,0.24147837366201,4943]
["Q96IJ6","Mannose-1-phosphate guanyltransferase alpha [OS=Homo sapiens]",32,11,44,11,420,46.3,7.21,135.66,"other metabolic processes","other cell component","other molecular function","GMPPA","ENSG00000144591","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars","Synthesis of GDP-mannose","",4512.1,4623.8,4724.7,4441.5,4357.7,5245,0.9869269876532661,-0.018984736088929744,0.8428693115050956,0.07423975834337279,0.8992164352343809,0.046135763978783224,6851]
["Q96IV0","Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase [OS=Homo sapiens]",18,12,23,12,654,74.3,6.89,58.16,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","NGLY1","ENSG00000151092","Protein processing in endoplasmic reticulum","N-glycan trimming in the ER and Calnexin/Calreticulin cycle","",2923.2,2972.1,2917.4,2981.9,2885.8,3108.2,0.9818179792555618,-0.02647250900908853,0.46047480504818306,0.33679412730836544,0.6186783731796268,0.2085350651225724,5440]
["Q96JB2-1","Conserved oligomeric Golgi complex subunit 3 [OS=Homo sapiens]",15,10,13,10,828,94,5.57,37.33,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi","","COG3","ENSG00000136152","","COPI-mediated anterograde transport; Retrograde transport at the Trans-Golgi-Network; Intra-Golgi traffic","",793.2,793.1,808.3,801.7,813.5,883.3,0.9584150490294178,-0.06127753339082229,0.2530301197684299,0.5968277789402039,0.4826192968130099,0.31639531746273775,3832]
["Q96JJ7-1","Protein disulfide-isomerase TMX3 [OS=Homo sapiens]",43,17,88,16,454,51.8,4.91,313.97,"protein metabolism;other metabolic processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","TMX3","ENSG00000166479; ENSGGOG00000005485","","Platelet degranulation","",7863,7873.8,8042.5,6808.6,7237.5,6445.9,1.1604186999804802,0.2146454496589979,0.009718422888207914,2.012404206938042,0.1038478843419761,0.9836023467741849,684]
["Q96JQ2","Calmin [OS=Homo sapiens]",10,8,10,8,1002,111.6,4.94,25.17,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;nucleus;other cell component","cytoskeletal activity","CLMN","ENSG00000165959","","","Vitamin D receptor pathway",575.9,563,556.3,586.1,652.4,614.1,0.9150383245168953,-0.12809592588129842,0.05906482294173697,1.228671093580487,0.2399693112179853,0.6198442950420654,1799]
["Q96K17-1","transcription factor BTF3 homolog 4 [OS=Homo sapiens]",29,4,19,2,158,17.3,6.35,49.87,"","","","Btf3l4; BTF3L4; LOC108587672; LOC110308160; LOC111143096","ENSAMEG00000009159; ENSANAG00000025045; ENSCAFG00000003782; ENSCANG00000032994; ENSCATG00000029142; ENSCCAG00000034219; ENSCGRG00001021460; ENSCGRG00015007601; ENSCJAG00000021582; ENSCJAG00000023403; ENSCPOG00000036248; ENSECAG00000024180; ENSFCAG00000024164; ENSG00000134717; ENSGGOG00000010677; ENSHGLG00000000408; ENSLCNG00005020988; ENSMFAG00000046175; ENSMLEG00000043474; ENSMMUG00000003636; ENSMNEG00000032806; ENSMODG00000000770; ENSMUSG00000028568; ENSMUSG00000114133; ENSNLEG00000016041; ENSOCUG00000001517; ENSPANG00000025278; ENSPCOG00000026062; ENSPPAG00000025800; ENSPTRG00000000735; ENSRBIG00000044688; ENSRFEG00010003696; ENSRNOG00000008512; ENSSHAG00000025846; ENSSSCG00000038762; ENSSSCG00070030088; ENSSSUG00005008763; ENSSTOG00000006129; ENSTSYG00000033616; ENSUMAG00000022798","","","",575.8,578.1,645.1,839.2,963.3,434.5,0.8042020563254358,-0.31437006980763665,0.4164823038997425,0.38040344679492033,0.5916558132562134,0.22793086400939908,5145]
["Q96KG9","N-terminal kinase-like protein [OS=Homo sapiens]",35,22,48,22,808,89.6,6.3,144.42,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;kinase activity;other molecular function","SCYL1","ENSG00000142186","","","",5486.2,5750,5921.8,5291.8,5294.8,4302.1,1.1524176052979775,0.20466360559833818,0.09934398068507663,1.002858441935657,0.3123032923988065,0.5054234372776567,2325]
["Q96KM6","zinc finger protein 512B [OS=Homo sapiens]",8,5,5,5,892,97.2,9.83,17.38,"","nucleus","nucleic acid binding activity;other molecular function","ZNF512B","ENSG00000196700","","RHOV GTPase cycle","",309.6,300,298.2,364.4,357.6,324.9,0.8671315311873148,-0.20567724907684998,0.02172871923143553,1.6629658717978804,0.14746073246291763,0.831323613211889,1077]
["Q96L91-5","Isoform 5 of E1A-binding protein p400 [OS=Homo sapiens]",5,13,17,13,3122,339.5,9.16,50.24,"","","","EP400","","","","",1273.5,1299.4,1273.1,1548.5,1447.1,2157.1,0.7464047974848138,-0.4219698358074089,0.12112487766010602,0.916766648591892,0.3458209886006699,0.4611486520197686,2560]
["Q96LT4-1","Sphingomyelin synthase-related protein 1 [OS=Homo sapiens]",3,1,1,1,415,48.3,8.07,3.67,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi","other molecular function","SAMD8","ENSG00000156671; ENSGGOG00000011029; ENSPTRG00000002656","","Sphingolipid de novo biosynthesis","",33,36.8,33.2,28.5,23.2,22,1.3975576662143827,0.48290781297551116,0.014146310325922644,1.849356819082814,0.12221676379688959,0.9128692202378647,846]
["Q96LZ7-1","Regulator of microtubule dynamics protein 2 [OS=Homo sapiens]",3,1,1,1,410,47.4,6.54,2.41,"","other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cell component","cytoskeletal activity","RMDN2","ENSG00000115841","","","",27.3,25.2,26.7,31.9,29.7,34.7,0.822429906542056,-0.28203536776384974,0.02241533511841845,1.6494547638697052,0.14880443631291596,0.827384120957484,1101]
["Q96MG8-1","Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 [OS=Homo sapiens]",9,4,6,4,357,40.7,5.66,10.9,"protein metabolism;other metabolic processes","other membranes;other cell component","other molecular function","PCMTD1","ENSG00000168300; ENSGGOG00000025636; ENSPPAG00000008533; ENSPPYG00000018582; ENSPTRG00000020242","","","",829.5,792.2,776.9,769.1,745.6,702.2,1.0819612973070503,0.11364889363623465,0.07300586200955646,1.136642266781032,0.2674685941994226,0.5727272049198261,1995]
["Q96MW5","Conserved oligomeric Golgi complex subunit 8 [OS=Homo sapiens]",17,9,13,9,612,68.4,5.2,41.01,"transport","other membranes;ER/Golgi","","COG8","ENSG00000213380","","COPI-mediated anterograde transport; Retrograde transport at the Trans-Golgi-Network; Intra-Golgi traffic","",661,665.9,676.7,740.8,766.3,1032.7,0.7888810142530908,-0.3421203777816749,0.12837716658443107,0.8915122138700461,0.3539451944796706,0.45106397971916656,2651]
["Q96N11","Uncharacterized protein C7orf26 [OS=Homo sapiens]",4,1,2,1,449,50,7.69,4.92,"","","","C7orf26","ENSG00000146576","","","",23.1,21.2,19.7,16.9,20.5,24.2,1.038961038961039,0.055141554192461154,0.7481814699684411,0.1259930520722027,0.8295598246358217,0.0811522888772891,6592]
["Q96NC0","Zinc finger matrin-type protein 2 [OS=Homo sapiens]",14,2,2,2,199,23.6,9.01,4.03,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","ZMAT2","ENSG00000146007","Spliceosome","","",136,157.9,139.1,140.3,138.7,81.7,1.2004435819240367,0.26356760182651706,0.3039367558780191,0.5172167763605116,0.5238089480576378,0.2808270869362482,4241]
["Q96ND0","Protein FAM210A [OS=Homo sapiens]",11,3,8,3,272,30.8,9.76,22.34,"","other membranes;mitochondrion;other cell component","","FAM210A","ENSG00000177150","","","",1407.6,1439.8,1545.9,1388.2,1360,1193.9,1.1144567616245147,0.15634064441285625,0.11057511155784354,0.9563426138038804,0.3305494848164738,0.48076351537954654,2445]
["Q96P16-1","Regulation of nuclear pre-mRNA domain-containing protein 1A [OS=Homo sapiens]",25,6,11,5,312,35.7,7.55,38.34,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","LOC111142439; P15RS; RPRD1A","ENSAMEG00000000830; ENSANAG00000021312; ENSBIXG00000008485; ENSBIXG00005019871; ENSBTAG00000005497; ENSCAFG00000017862; ENSCCAG00000025615; ENSCJAG00000021044; ENSDLEG00000001661; ENSG00000141425; ENSGGOG00000007369; ENSLCNG00005017687; ENSMPUG00000001133; ENSNLEG00000006228; ENSOARG00000005585; ENSPCTG00005006209; ENSPPAG00000027698; ENSPPYG00000009111; ENSPTRG00000009974; ENSRFEG00010007667; ENSSBOG00000026758; ENSSSUG00005007348; ENSSTOG00000003343; ENSTSYG00000006414; ENSTTRG00000007088; ENSUMAG00000002096; ENSVVUG00000027590","","RNA polymerase II transcribes snRNA genes; RNA polymerase II transcribes snRNA genes","",376.2,363.4,372.1,467.1,485.1,466.2,0.7837704455724759,-0.35149692208747063,1.4443423804025784E-4,3.840329845343761,0.014265808727516819,1.845703603190764,74]
["Q96PE3-1","Type I inositol 3,4-bisphosphate 4-phosphatase [OS=Homo sapiens]",32,25,69,25,977,109.9,6.96,235.14,"other metabolic processes;signal transduction","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","INPP4A","ENSG00000040933","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of IP2, IP, and Ins in the cytosol","Insulin signaling",5626.8,5760.2,5785.5,5698.8,5755.4,6536.2,0.9545368641053006,-0.06712717946357923,0.37705310481454346,0.4235974786968147,0.5689267429994834,0.24494365128385642,4844]
["Q96PU5","E3 ubiquitin-protein ligase NEDD4-like [OS=Homo sapiens]",11,8,12,5,975,111.9,5.82,32.67,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","NEDD4L","ENSG00000049759","Ubiquitin mediated proteolysis; Endocytosis; Tight junction; Aldosterone-regulated sodium reabsorption","Stimuli-sensing channels; Antigen processing: Ubiquitination & Proteasome degradation; Budding and maturation of HIV virion; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity","TGF-beta signaling pathway",448,423.9,473.8,434.4,478.7,567.9,0.9086428089128966,-0.13821481816157777,0.3415164830629667,0.4665883305460259,0.5473999944533385,0.26169521132648793,4560]
["Q96PZ2","Protein FAM111A [OS=Homo sapiens]",9,4,5,4,611,70.2,8.53,22.54,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","FAM111A","ENSG00000166801","","","",233.1,218.8,231.9,183.8,233.5,332.3,0.9122198505869796,-0.13254653022579246,0.643442487739657,0.1914902651908855,0.7521063718037987,0.12372073198758102,6253]
["Q96QC0","Serine/threonine-protein phosphatase 1 regulatory subunit 10 [OS=Homo sapiens]",20,19,31,19,940,99,9.17,61.29,"transport;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","PPP1R10","ENSG00000204569; ENSG00000206489; ENSG00000227804; ENSG00000230995; ENSG00000231737; ENSG00000235291; ENSG00000238104","","","",4542.5,4318,4361.8,4978.2,5265.5,4921,0.8719130612540966,-0.19774380432381594,0.006954903481821148,2.157708892645815,0.08659861933327218,1.0624890320094564,587]
["Q96QE3-1","ATPase family AAA domain-containing protein 5 [OS=Homo sapiens]",4,4,4,4,1844,207.4,9.19,6.82,"stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ATAD5","ENSG00000176208","","","",158,164.6,166,260.8,289.2,282.7,0.5867659421160082,-0.7691429603557726,0.000212546952000388,3.6725451185910183,0.016182350751779543,1.7909583897466135,96]
["Q96QT6-1","PHD finger protein 12 [OS=Homo sapiens]",3,2,2,2,1004,109.6,7.74,5.82,"other biological processes","nucleus;other cell component","other molecular function","PHF12","ENSG00000109118","","","",64.3,53.8,70.8,66,84.1,52.2,0.9337617399901136,-0.09887361816991339,0.6919060810892721,0.1599528524115239,0.7899315130711481,0.10241056033566445,6402]
["Q96R06","Sperm-associated antigen 5 [OS=Homo sapiens]",22,16,29,16,1193,134.3,5,88.13,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity","SPAG5","ENSG00000076382","","","",1608.9,1605.1,1702.3,1794.8,1756.3,4725.7,0.5939855982988596,-0.7515001428422895,0.31849800716681875,0.49689328068863575,0.5350268752889631,0.27162440209737976,4351]
["Q96RP9","Elongation factor G, mitochondrial [OS=Homo sapiens]",38,27,168,1,751,83.4,7.01,461.06,"protein metabolism;other metabolic processes","mitochondrion","nucleic acid binding activity;other molecular function","GFM1","ENSG00000168827","","Mitochondrial translation elongation","",424.7,423.5,426.8,459.4,406.4,581,0.8812551838540227,-0.18236825602219156,0.3300592371197022,{"$f":"-LOG10(AA5379)","v":0.4814081084691917},0.5412616028960967,{"$f":"-LOG10(AC5379)","v":0.26659278067139514},4457]
["Q96RS0","Trimethylguanosine synthase [OS=Homo sapiens]",11,6,7,6,853,96.6,4.94,20.72,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","TGS1","ENSG00000137574","","Heme signaling; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); RORA activates gene expression; snRNP Assembly","",322.3,348,378.7,389.3,398.7,458.4,0.8416238767650834,-0.24875246059703926,0.07207463599489757,1.1422175422912157,0.2656548232409008,0.5756822946125456,1983]
["Q96RT7","gamma-tubulin complex component 6 [OS=Homo sapiens]",2,4,5,4,1819,200.4,6.32,14.98,"cell cycle OR cell proliferation;cell organization and biogenesis","cytosol;cytoskeleton","cytoskeletal activity","TUBGCP6","ENSG00000128159","","Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes","15q11.2 copy number variation syndrome",352.3,317.9,312.3,384,345.4,348.5,0.9114945727804064,-0.13369402868998917,0.1450519165035166,0.8384765286923878,0.37475590587635305,0.4262515142654056,2829]
["Q96S59-1","Ran-binding protein 9 [OS=Homo sapiens]",16,8,14,8,729,77.8,6.79,41.53,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","RANBP9","ENSG00000010017","","RAF/MAP kinase cascade; L1CAM interactions; MET activates RAS signaling","Brain-derived neurotrophic factor (BDNF) signaling pathway; Ciliary landscape",607.4,608.2,600.6,599.9,632.8,2635.3,0.46954498448810755,-1.0906647138155339,0.3670176873001283,0.4353130057431441,0.563320511649861,0.24924443492803214,4762]
["Q96SB8","structural maintenance of chromosomes protein 6 [OS=Homo sapiens]",18,16,39,16,1091,126.2,6.99,104.02,"cell organization and biogenesis;DNA metabolism;stress response;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMC6","ENSG00000163029","","SUMOylation of DNA damage response and repair proteins","",2462.5,2529,2539.6,2402.4,2450.8,2713.2,0.9953346373440473,-6.7464451396350815E-3,0.9115806406682423,0.04020490655027563,0.9446679289159483,0.024720828510904434,7053]
["Q96SK2","Transmembrane protein 209 [OS=Homo sapiens]",15,6,13,6,561,62.9,8.63,35.02,"","other membranes","","TMEM209","ENSG00000146842","","","",1442.8,1413.5,1427.6,1442.1,1503,2114.3,0.846720955053959,-0.24004150087776688,0.29516456609803987,0.5299357798833811,0.5168562083398595,0.2866302627288434,4174]
["Q96SU4","Oxysterol-binding protein-related protein 9 [OS=Homo sapiens]",18,12,31,12,736,83.1,6.18,87.81,"other metabolic processes;transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","OSBPL9","ENSG00000117859","","Synthesis of bile acids and bile salts","",3823.2,3985.8,4016,3944.6,3654,3240.4,1.0909678014576991,0.12560852296052039,0.1975364139014487,0.7043528347273267,0.43266216637869,0.3638510794981465,3337]
["Q96SZ5","2-aminoethanethiol dioxygenase [OS=Homo sapiens]",22,4,12,4,270,29.7,6.04,35.36,"","cytosol","other molecular function","ADO","ENSG00000181915","Taurine and hypotaurine metabolism; Metabolic pathways","Degradation of cysteine and homocysteine","",709.3,673.3,702.6,864.8,833.8,1452,0.6618421887894368,-0.5954408364533831,0.1526280640310906,0.8163656044332166,0.3840132598978455,0.41565377927559316,2905]
["Q96T66-1","Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 [OS=Homo sapiens]",4,1,1,1,252,28.3,9.22,1.77,"other metabolic processes","mitochondrion;nucleus","other molecular function","NMNAT3","ENSG00000163864","Nicotinate and nicotinamide metabolism; Metabolic pathways; Biosynthesis of cofactors","Nicotinate metabolism","NAD+ metabolism",55.3,50.4,61.6,56.9,61.1,125.5,0.6870636550308007,-0.5414843269313521,0.3208404750934879,0.4937108492378081,0.5357603455467908,0.27102943396694923,4377]
["Q99081-1","Transcription factor 12 [OS=Homo sapiens]",7,4,4,4,682,72.9,7.02,8.37,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TCF12","ENSG00000140262","","RUNX1 regulates transcription of genes involved in differentiation of HSCs; Myogenesis; NGF-stimulated transcription","",127.5,142.5,139.7,270.7,294.8,254.5,0.4996341463414634,-1.0010560169125073,4.0641108345343478E-4,3.391034456686167,0.02184160741883202,1.6607154031724116,136]
["Q99439","Calponin-2 [OS=Homo sapiens]",60,13,71,13,309,33.7,7.33,202.24,"cell organization and biogenesis;stress response;developmental processes;other biological processes","non-structural extracellular;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","CNN2","ENSG00000064666","","Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","Myometrial relaxation and contraction pathways; Burn wound healing",8859.5,8869.2,8925.4,9125.7,9593.1,9100.6,0.9581119650315966,-0.06173383563030708,0.07389303732109338,1.1313964817064923,0.2693686831819808,0.5696528967787206,2005]
["Q99471-1","prefoldin subunit 5 [OS=Homo sapiens]",44,5,13,5,154,17.3,6.33,46.55,"developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","LOC101567244; PFDN5","ENSCJAG00000018477; ENSG00000123349; ENSGGOG00000026308; ENSMFAG00000003143; ENSMMUG00000022030; ENSNLEG00000017706; ENSPPAG00000037126; ENSPPYG00000004575; ENSPTRG00000005010","","Prefoldin mediated transfer of substrate  to CCT/TriC","Cellular proteostasis",1251.5,1080.1,1330,1134.8,1939.2,971.7,0.9050596930073905,-0.1439151469283122,0.6989804250561658,0.15553498649913827,0.7951514282856833,0.09955015661849749,6425]
["Q99543-1","dnaJ homolog subfamily C member 2 [OS=Homo sapiens]",35,20,42,20,621,72,8.7,115.84,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;cytosol;nucleus;other cell component","translation activity;other molecular function","DNAJC2","ENSG00000105821","","Regulation of HSF1-mediated heat shock response","",5175.7,5128.9,5042.8,5345.8,5509,4623.6,0.9915365929295017,-0.012262078395163521,0.8814510619339081,0.05480179467724533,0.9226014337211706,0.03498587483428886,6983]
["Q99567","Nuclear pore complex protein Nup88 [OS=Homo sapiens]",29,17,57,17,741,83.5,5.69,186.33,"cell cycle OR cell proliferation;other metabolic processes;transport","cytosol;nucleus","transporter activity;other molecular function","NUP88","ENSG00000108559","Nucleocytoplasmic transport; Amyotrophic lateral sclerosis","HCMV Early Events; ISG15 antiviral mechanism; tRNA processing in the nucleus; HCMV Late Events; Transcriptional regulation by small RNAs; Viral Messenger RNA Synthesis; SUMOylation of DNA damage response and repair proteins; Rev-mediated nuclear export of HIV RNA; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)","Ciliary landscape",5750.2,5791.6,5840.6,5566.2,5504.2,4704.5,1.1019023892386006,0.13999643008100635,0.12689388483003405,0.896559306577981,0.3531863687062905,0.45199606644746854,2626]
["Q99576","TSC22 domain family protein 3 [OS=Homo sapiens]",43,4,5,3,134,14.8,4.54,11.75,"stress response;other biological processes","cytosol;nucleus","","TSC22D3","ENSG00000157514","","Stimuli-sensing channels","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway",435.1,452.9,547,753.2,790.2,501.5,0.7017458066409115,-0.5109795571063666,0.1044286857410204,0.9811801876573945,0.3200290415434458,0.49481060914955416,2385]
["Q99607","ETS-related transcription factor Elf-4 [OS=Homo sapiens]",1,1,1,1,663,70.7,5.6,2.6,"cell cycle OR cell proliferation;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ELF4","ENSG00000102034","","","TYROBP causal network in microglia",114.3,101.3,90.2,95.6,118,87,1.0172987358616101,0.02474339744444012,0.8881666935655801,0.05150551698973935,0.9271080210326799,0.03286966153478022,7002]
["Q99638","cell cycle checkpoint control protein rad9a [OS=Homo sapiens]",10,2,5,2,391,42.5,5.66,20.5,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus","other molecular function","RAD9A","ENSG00000172613","Cellular senescence","Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Activation of ATR in response to replication stress; Presynaptic phase of homologous DNA pairing and strand exchange; HDR through Single Strand Annealing (SSA)","Androgen receptor signaling pathway; miRNA regulation of DNA damage response; ATM signaling pathway; ATR signaling; DNA IR-double strand breaks and cellular response via ATM; DNA damage response",135.8,150.9,144.2,125.8,124.4,126.6,1.1435774946921446,0.1935541334975998,0.015044916887120539,1.8226102070973553,0.12495829264541365,0.903234917363551,880]
["Q99717","mothers against decapentaplegic homolog 5 [OS=Homo sapiens]",10,5,13,1,465,52.2,7.71,36.7,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMAD5","ENSG00000113658","TGF-beta signaling pathway; Signaling pathways regulating pluripotency of stem cells","Signaling by BMP","Differentiation of white and brown adipocyte; BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation; BMP signaling in eyelid development; Embryonic stem cell pluripotency pathways; Genotoxicity pathway; Neovascularisation processes; Osteoblast differentiation and related diseases; TGF-beta receptor signaling in skeletal dysplasias; Network map of SARS-CoV-2 signaling pathway; TGF-beta receptor signaling",1188.8,1368.7,1403.6,1294.6,1438.7,500,1.2250951040732379,0.29289374992093686,0.4631634224566335,0.33426574559428895,0.6204658091524073,0.20728214535873846,5456]
["Q99732","Lipopolysaccharide-induced tumor necrosis factor-alpha factor [OS=Homo sapiens]",4,1,1,1,161,17.1,6.44,2.51,"other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","LITAF","ENSG00000189067","Lysosome","","Intracellular trafficking proteins involved in CMT neuropathy",545.4,517.1,628.1,483,545.1,748,0.9518608186475986,-0.07117745720122294,0.7587779425132576,0.11988530243283681,0.837623921134179,0.07695092843018134,6621]
["Q99766-1","ATP synthase subunit s, mitochondrial [OS=Homo sapiens]",5,1,1,1,215,24.9,7.56,2.9,"other metabolic processes;transport","other membranes;mitochondrion;other cell component","transporter activity;other molecular function","DMAC2L","ENSG00000125375","","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",101.1,99.1,98.7,90.2,93.5,63.2,1.2106115836371,0.2757360605353127,0.1461249778080946,0.8352755417861191,0.3761984722787473,0.4245829724280033,2839]
["Q99832","T-complex protein 1 subunit eta [OS=Homo sapiens]",67,29,204,29,543,59.3,7.65,700.66,"transport;other biological processes","cytosol;cytoskeleton;other cell component","other molecular function","CCT7","ENSG00000135624","","Formation of tubulin folding intermediates by CCT/TriC; Association of TriC/CCT with target proteins during biosynthesis; RHOBTB1 GTPase cycle; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate  to CCT/TriC; RHOBTB2 GTPase cycle; Folding of actin by CCT/TriC","VEGFA-VEGFR2 signaling pathway; 16p11.2 proximal deletion syndrome",25199.8,26681.1,26937.5,24108.4,23910.8,21103.7,1.1402646590348497,0.18936871733966287,0.04374997742483779,1.3590221667392886,0.20630231290202544,0.6854959030256071,1550]
["Q99856","AT-rich interactive domain-containing protein 3A [OS=Homo sapiens]",21,12,15,12,593,62.9,4.91,37.81,"other biological processes","other membranes;cytosol;nucleus","nucleic acid binding activity;other molecular function","ARID3A","ENSG00000116017","","TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest","",1155.2,1183.8,1138.1,1251.8,1304.7,1370.3,0.8854792706529488,-0.1754695614575977,0.015146017511237673,1.8197015453966894,0.12537060247976914,0.9018042870902852,883]
["Q99962","Endophilin-A1 [OS=Homo sapiens]",24,8,26,3,352,39.9,5.45,63.46,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SH3GL2","ENSG00000107295","Endocytosis","Golgi Associated Vesicle Biogenesis; MHC class II antigen presentation; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; Lysosome Vesicle Biogenesis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Retrograde neurotrophin signalling","EGF/EGFR signaling pathway",260,272.7,302.7,273.3,259.5,487.1,0.8190999117560547,-0.28788865595932367,0.45689616399948124,0.3401824881707151,0.6163628760930617,0.21016352698389154,5418]
["Q99996-2","Isoform 2 of A-kinase anchor protein 9 [OS=Homo sapiens]",29,95,152,1,3907,452.7,4.98,440.93,"cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","AKAP9","ENSG00000127914","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Signaling by BRAF and RAF1 fusions; Phase 3 - rapid repolarisation; Phase 2 - plateau phase","G protein signaling pathways; NO/cGMP/PKG mediated neuroprotection",64.1,61.7,59.8,87,69.6,84.1,0.7710843373493976,-0.37503943134692463,0.029246302176176818,1.533929037137453,0.16978651517527907,0.7700968053613427,1259]
["Q9BPZ7","Target of rapamycin complex 2 subunit MAPKAP1 [OS=Homo sapiens]",6,2,2,2,522,59.1,7.55,4.33,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","MAPKAP1","ENSG00000119487","mTOR signaling pathway","PIP3 activates AKT signaling; CD28 dependent PI3K/Akt signaling; Regulation of TP53 Degradation; Constitutive Signaling by AKT1 E17K in Cancer; VEGFR2 mediated vascular permeability","Target of rapamycin (TOR) signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Head and neck squamous cell carcinoma; Interferon type I signaling pathways",115.7,111.9,122.4,111.5,137.3,208.4,0.7655293088363955,-0.385470481494787,0.28729003636141875,0.5416794357145984,0.5106524503321035,0.29187457981784487,4112]
["Q9BQ75","Protein CMSS1 [OS=Homo sapiens]",11,2,4,2,279,31.9,9.19,14.34,"","","","CMSS1","ENSG00000184220","","","",570.1,533.3,555.6,718.7,725.5,180.7,1.0209859068250353,0.029962952117811716,0.9528857798776025,0.020959154074986087,0.9721722731889163,0.012256769368007047,7164]
["Q9BQA9-1","Uncharacterized protein C17orf62 [OS=Homo sapiens]",21,5,25,5,187,20.8,6.8,67.12,"other metabolic processes;stress response","other membranes;ER/Golgi","","C17orf62; CYBC1","ENSG00000178927; ENSGGOG00000001586; ENSPPAG00000037586; ENSPTRG00000009804","","","",3561.7,3478.7,3356.4,3330.1,3147.7,2832.8,1.1166627285029966,0.1591935068678668,0.08239151906254001,1.084117489927876,0.2856734406205431,0.5441301345844122,2108]
["Q9BQG0","Myb-binding protein 1A [OS=Homo sapiens]",42,43,162,43,1328,148.8,9.28,491.28,"other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MYBBP1A","ENSG00000132382","","B-WICH complex positively regulates rRNA expression","Energy metabolism",13461.2,13261.8,13477,19236,18750.8,21339.1,0.6776129818510971,-0.5614665804994341,0.001326720690622347,2.8772204978508906,0.03990535608131167,1.39896880956523,243]
["Q9BRD0","BUD13 homolog [OS=Homo sapiens]",14,7,12,7,619,70.5,9.86,32.44,"RNA metabolism OR transcription;other metabolic processes","nucleus","","BUD13","ENSG00000137656","","","",876.1,839.5,761.5,1060.8,1097,1046.7,0.7730067093150256,-0.37144715880514595,2.7942263741148323E-3,2.5537384124500413,0.05564850291118613,1.2545465148181576,367]
["Q9BRJ2","39S ribosomal protein L45, mitochondrial [OS=Homo sapiens]",43,12,47,12,306,35.3,9.03,113.97,"","other membranes;mitochondrion;translational apparatus","","MRPL45","ENSG00000277936","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",5441.8,5525.9,5553.7,5012.8,5002,5541.4,1.0620460009513895,0.08684625569683742,0.15042022812799716,0.8226937570046682,0.3813463223682037,0.41868043750890305,2883]
["Q9BRP8","Partner of Y14 and mago [OS=Homo sapiens]",9,1,2,1,204,22.6,9.45,7.99,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","translation activity","PYM1","ENSG00000170473","Nucleocytoplasmic transport; mRNA surveillance pathway","","",171.6,88.8,88,146,67.2,179.7,0.886739628404174,-0.1734175438598223,0.7495147454371511,0.1252198187209786,0.8300307991515359,0.08090579237887437,6600]
["Q9BRR6-1","ADP-dependent glucokinase [OS=Homo sapiens]",28,8,22,8,497,54.1,6.2,86.21,"other metabolic processes","non-structural extracellular;other membranes;ER/Golgi","kinase activity;other molecular function","ADPGK","ENSG00000159322; ENSPPAG00000038547; ENSPTRG00000007256","Glycolysis / Gluconeogenesis; Metabolic pathways; Carbon metabolism","Glycolysis","",2061.2,1961.3,1955.2,1895.7,1858.2,1815.7,1.0732727664464232,0.10201677580553065,0.030356000835900964,1.5177554438866119,0.17252877924541224,0.7631384505908422,1286]
["Q9BRX5","DNA replication complex GINS protein PSF3 [OS=Homo sapiens]",19,3,3,3,216,24.5,5.34,11.94,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes","nucleus","","GINS3","ENSG00000181938","","Unwinding of DNA","",407.4,417.6,415.1,446.3,507.4,448.6,0.8843328816943591,-0.1773385619553105,0.055644443942829525,{"$f":"-LOG10(AA5571)","v":1.2545781931519622},0.2332025463177414,{"$f":"-LOG10(AC5571)","v":0.6322667118645378},1744]
["Q9BSB4","Autophagy-related protein 101 [OS=Homo sapiens]",19,4,6,4,218,25,6.15,20.06,"cell organization and biogenesis;other metabolic processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","ATG101","ENSG00000123395","Autophagy; Autophagy; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration","Macroautophagy","Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Alzheimer's disease",455.8,557.2,538.2,596.5,512.2,292,1.1074462768615692,0.1472367141434471,0.6287400264963692,0.20152889095700394,0.7414425385062863,0.12992250097629518,6198]
["Q9BSE5","Agmatinase, mitochondrial [OS=Homo sapiens]",12,5,17,5,352,37.6,7.59,48.36,"other metabolic processes","mitochondrion","other molecular function","AGMAT","ENSG00000116771","Arginine and proline metabolism; Metabolic pathways","Agmatine biosynthesis","",2300.6,2380.1,2382.1,2128.8,2055.2,2175.5,1.1105904552244672,0.15132690210521965,6.031196085789876E-3,2.2195965515502434,0.08029510417311148,1.0953109341163623,549]
["Q9BSJ8","Extended synaptotagmin-1 [OS=Homo sapiens]",36,32,121,32,1104,122.8,5.83,371.03,"cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi","other molecular function","ESYT1","ENSG00000139641","","RAC1 GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; Glycosphingolipid metabolism; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle","",11998.8,11820.2,11935.8,11421.1,11325.1,11635.5,1.0399369431994347,0.05649605289381035,0.012312084391868665,1.909668416341192,0.11566712701821089,0.936790051446908,778]
["Q9BT17-1","Mitochondrial ribosome-associated GTPase 1 [OS=Homo sapiens]",10,3,8,3,334,37.2,9.47,26.68,"other biological processes","other membranes;mitochondrion;translational apparatus","other molecular function","MTG1","ENSG00000148824","","","",449.8,486.1,489.3,421.3,467.8,732,0.8791561285546851,-0.18580869983746287,0.5400065644986184,0.26760096071740563,0.6766514623556321,0.1696349752634481,5833]
["Q9BT30","Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial [OS=Homo sapiens]",10,1,1,1,221,24.5,7.11,0,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","mitochondrion","other molecular function","ALKBH7","ENSG00000125652","","","",67.2,54.6,61.9,95,98.1,219.2,0.4455493572641282,-1.166342834776715,0.13703289475986302,0.8631751678955972,0.3638116337812709,0.4391234174049546,2753]
["Q9BTC0","Death-inducer obliterator 1 [OS=Homo sapiens]",18,31,59,31,2240,243.7,7.88,180.8,"RNA metabolism OR transcription;other metabolic processes;signal transduction","cytoskeleton;nucleus;other cell component","other molecular function","DIDO1","ENSG00000101191","","","",5113.7,4857.1,4846.3,6515.9,6468.9,8253.1,0.6976725570795606,-0.5193780084773721,0.022636498933229048,1.6451907423051748,0.1491886119954654,0.8262643265703619,1109]
["Q9BTE3-1","Mini-chromosome maintenance complex-binding protein [OS=Homo sapiens]",19,10,22,10,642,72.9,5.87,64.67,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","MCMBP","ENSG00000197771; ENSGGOG00000006006; ENSPTRG00000003000","","","",2017.9,2130.9,1999,2513.5,2607.7,2619,0.7942688819410352,-0.3323006127387787,5.6073102086096635E-4,3.2512454171205545,0.02545579522653915,1.5942133312684312,161]
["Q9BTU6","Phosphatidylinositol 4-kinase type 2-alpha [OS=Homo sapiens]",30,15,31,14,479,54,8.29,65.4,"cell organization and biogenesis;other metabolic processes;transport","plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","PI4K2A","ENSG00000155252","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane","Thymic stromal lymphopoietin (TSLP) signaling pathway; Wnt signaling pathway",3558.7,3584.4,3718.8,3044.6,3218.8,2953.2,1.1785148536336614,0.23696994198101892,0.00403558155762864,2.394093871333551,0.06673318010114872,1.1756581787986697,442]
["Q9BTZ2","dehydrogenase/reductase sdr family member 4 [OS=Homo sapiens]",41,8,10,7,278,29.5,8.56,37.38,"other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle","other molecular function","DHRS4","ENSG00000157326; ENSG00000284807","Retinol metabolism; Metabolic pathways; Peroxisome","Peroxisomal protein import; RA biosynthesis pathway","",1860.9,2079.4,2058.3,1788.5,1679.7,2416.4,1.0193725996669272,0.02768147980391842,0.881819723052368,0.05462019183650681,0.9225909470068362,0.034990811254161786,6986]
["Q9BU61-1","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [OS=Homo sapiens]",38,5,23,5,184,20.3,8.22,88.46,"cell organization and biogenesis","other membranes;mitochondrion;nucleus","","NDUFAF3","ENSG00000178057","Thermogenesis","Complex I biogenesis","",1663.5,1643.1,1627.5,2008,1792.1,2170.4,0.8264131982246044,-0.2750647999521328,0.03488858548927836,1.4573166380799518,0.18345372038930613,0.7364734764500739,1390]
["Q9BUE0","Mediator of RNA polymerase II transcription subunit 18 [OS=Homo sapiens]",15,2,3,2,208,23.6,6.54,5.4,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","MED18","ENSG00000130772; ENSG00000284944","","Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression","",165.1,166.9,172.3,148.7,183.5,211.9,0.9268516816761624,-0.10958960310252715,0.5108561347177033,0.29170138693981557,0.6563275599668998,0.1828793588236142,5689]
["Q9BUL5-1","PHD finger protein 23 [OS=Homo sapiens]",5,2,3,2,403,43.8,5.78,6.47,"other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","PHF23","ENSG00000040633; ENSGGOG00000005820; ENSPPAG00000042657","","","",210.4,191.7,197.4,250.6,258.1,1019.8,0.39221458946679755,-1.3502848934727463,0.29174830129669377,0.5349916639530978,0.5142002252658633,0.2888677374331427,4147]
["Q9BUR5-1","MICOS complex subunit MIC26 [OS=Homo sapiens]",32,5,14,5,198,22.3,9.13,45.62,"cell organization and biogenesis;transport","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi","","APOO","ENSG00000184831; ENSGGOG00000001200; ENSNLEG00000010026; ENSPPYG00000020191","","Cristae formation","",1638,1632.5,1710.2,1416.8,1550.8,1104.2,1.2232182327226289,0.2906818161135774,0.08766074214104486,1.0571948569036402,0.2932322033450329,0.532788336326108,2185]
["Q9BV23","Monoacylglycerol lipase ABHD6 [OS=Homo sapiens]",11,3,3,3,337,38.3,8.41,9.05,"other metabolic processes;other biological processes","plasma membrane;other membranes;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","ABHD6","ENSG00000163686","Retrograde endocannabinoid signaling","Arachidonate production from DAG","",145.5,133.1,131,136.4,143.4,1496,0.23065660547358938,-2.1161814864311825,0.3707411118683827,0.4309292519321791,0.566300268891538,0.24695323216106854,4785]
["Q9BV44","THUMP domain-containing protein 3 [OS=Homo sapiens]",9,6,15,6,507,57,6.37,44.86,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","THUMPD3","ENSG00000134077","","","",1850.7,2082.2,2050.1,1995.8,2124.5,704.2,1.2401285107265,0.3104896304356833,0.4477546014749005,0.34895994230776545,0.6099978345163183,0.21467170672576236,5365]
["Q9BV94-1","ER degradation-enhancing alpha-mannosidase-like protein 2 [OS=Homo sapiens]",5,3,7,3,578,64.7,5.31,14.41,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi","other molecular function","EDEM2","ENSG00000088298","Protein processing in endoplasmic reticulum","ER Quality Control Compartment (ERQC); Maturation of spike protein","",832.6,842.5,833.9,834.8,856.2,783.5,1.0139422105475853,0.01997542854216948,0.6256240344202304,0.20368657546038538,0.7389602565574441,0.1313789186037423,6188]
["Q9BVI4","Nucleolar complex protein 4 homolog [OS=Homo sapiens]",24,8,15,8,516,58.4,7.49,51.37,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","","NOC4L","ENSG00000184967; ENSG00000288146","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",1210.3,1142.4,1189.7,1930.9,1897.3,2223.6,0.5853465084768169,-0.7726371828975723,1.3724197437944851E-3,2.8625130427585934,0.040447644787878594,1.3931067617008366,248]
["Q9BVK2-1","Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase [OS=Homo sapiens]",5,2,4,2,526,60,9.14,10.37,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","ALG8","ENSG00000159063","N-Glycan biosynthesis; Metabolic pathways","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG8 causes CDG-1h","",201.5,233,222.9,167.4,203.1,220.2,1.1129168782800067,0.15434584445760022,0.2869932533354521,0.5421283125817705,0.5103731602503211,0.2921121725738668,4110]
["Q9BVQ7-1","Spermatogenesis-associated protein 5-like protein 1 [OS=Homo sapiens]",29,11,17,11,753,80.7,8.09,54.08,"","cytoskeleton;other cell component","other molecular function","SPATA5L1","ENSG00000171763","","","",413.2,413.6,383,359,392.2,674.2,0.8487442121509751,-0.2365982636796914,0.5140949068914453,0.2889566986420064,0.6580594876479114,0.18173484500388143,5710]
["Q9BW60","Elongation of very long chain fatty acids protein 1 [OS=Homo sapiens]",4,1,1,1,279,32.6,9.6,2.12,"other metabolic processes;developmental processes","other membranes;ER/Golgi","other molecular function","ELOVL1","ENSG00000066322","Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism","Synthesis of very long-chain fatty acyl-CoAs; alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism","Omega-9 fatty acid synthesis",87.1,73.3,75,79.3,78,98.5,0.920250195465207,-0.11990194384319304,0.4392066591624546,0.35733108382302875,0.6045501830166442,0.21856764302052487,5310]
["Q9BW62","katanin p60 ATPase-containing subunit A-like 1 [OS=Homo sapiens]",8,3,4,2,490,55.4,6.74,11.03,"cell organization and biogenesis;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KATNAL1","ENSG00000102781","","","",95.8,79.2,75.9,92.9,85,94.5,0.9210719530102791,-0.11861423260289843,0.35274553687740234,0.4525384724617178,0.5536218872744114,0.2567867485104761,4657]
["Q9BWF3-1","RNA-binding protein 4 [OS=Homo sapiens]",46,15,44,15,364,40.3,7.08,116.4,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RBM14; RBM4","ENSCATG00000036313; ENSG00000173933; ENSGGOG00000014455; ENSMFAG00000052468; ENSMLEG00000024601; ENSMMUG00000020363; ENSMNEG00000014872; ENSNLEG00000035021; ENSPPAG00000033403; ENSPTRG00000003934; ENSRBIG00000043267; ENSRROG00000044302","","Circadian Clock","",6046.5,6231.1,6237.7,4341.3,4349.3,4171,1.4395798345462463,0.5256477984256467,2.5055900053649575E-5,4.601089991991047,0.007962329282266294,2.098959866124666,23]
["Q9BWL3","Uncharacterized protein C1orf43 [OS=Homo sapiens]",9,2,2,2,253,28.8,9.6,6.68,"transport","other membranes;mitochondrion;ER/Golgi","","C1orf43","ENSG00000143612","","","",197.4,183.2,175.8,240.2,253.2,247,0.7514856834143708,-0.4121824753283346,1.1366886346320976E-3,2.944358482348303,0.036924698802337785,1.4326830385756926,225]
["Q9BX10","GTP-binding protein 2 [OS=Homo sapiens]",2,1,1,1,602,65.7,8.05,1.96,"protein metabolism;other metabolic processes","non-structural extracellular;other cell component","nucleic acid binding activity;other molecular function","GTPBP2","ENSG00000172432","","Platelet degranulation","Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway",61.3,67.1,70,110.4,82.2,156.9,0.5676680972818311,-0.8168804298759238,0.08322444551356001,1.0797490896672803,0.2870634602447429,0.5420220844941019,2119]
["Q9BXB4","Oxysterol-binding protein-related protein 11 [OS=Homo sapiens]",28,15,32,15,747,83.6,7.06,106.32,"transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","OSBPL11","ENSG00000144909","","RHOH GTPase cycle","",2538.1,2604,2687.4,2844.2,2722.2,2097.5,1.021607797596524,0.03084144181234252,0.8260168918528689,0.08301107136789936,0.8857625385200438,0.05268269124257008,6816]
["Q9BXF6","Rab11 family-interacting protein 5 [OS=Homo sapiens]",13,7,11,7,653,70.4,9.23,33.04,"cell-cell signaling;transport;other biological processes","other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB11FIP5","ENSG00000135631","Endocytosis","","",1074,1051.8,1072.2,1218.1,1257.4,1959.7,0.7210497835497837,-0.47182922376951913,0.16224224443675633,0.7898360543354417,0.3939629782685223,0.40454458804531207,3010]
["Q9BXL7","Caspase recruitment domain-containing protein 11 [OS=Homo sapiens]",14,13,15,13,1154,133.2,6.09,42.42,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","kinase activity;other molecular function","CARD11","ENSG00000198286","NF-kappa B signaling pathway; T cell receptor signaling pathway; B cell receptor signaling pathway","FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; Activation of NF-kappaB in B cells","B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Modulators of TCR signaling and T cell activation; T-cell receptor (TCR) signaling pathway",1034.1,977.9,1030.3,1108,1116.3,1391.9,0.8412974946075991,-0.24931204696150108,0.11439205765480877,0.9416041279593561,0.3367263590008044,0.47272288562994746,2483]
["Q9BXS9-1","Solute carrier family 26 member 6 [OS=Homo sapiens]",3,3,5,3,759,82.9,8.37,11.45,"stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component","transporter activity;other molecular function","SLC26A6","ENSG00000225697","Mineral absorption; Chemical carcinogenesis","Multifunctional anion exchangers","Proximal tubule transport",989.1,932.4,975.2,850.8,873.7,1081.8,1.032213234508071,0.04574103334820209,0.7099679178040088,0.14876127583795024,0.8015377681849707,0.0960760090205316,6474]
["Q9BY12","S phase cyclin A-associated protein in the endoplasmic reticulum [OS=Homo sapiens]",5,6,9,6,1400,158.2,7.44,19.34,"","cytosol;ER/Golgi;nucleus","nucleic acid binding activity;other molecular function","SCAPER","ENSG00000140386","","","",644.8,634.5,652.3,725.9,802,707.4,0.8641345680669261,-0.21067210013094168,0.02622304656426802,1.5813168538668003,0.15945444870069464,0.7973633596495482,1202]
["Q9BY43","Charged multivesicular body protein 4a [OS=Homo sapiens]",31,6,11,6,222,25.1,4.7,34.79,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","CHMP4A","ENSG00000254505; ENSG00000285302","Endocytosis; Necroptosis","HCMV Late Events; Late endosomal microautophagy; Pyroptosis; Sealing of the nuclear envelope (NE) by ESCRT-III; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","",1024.4,857.1,1033.6,1582,2041.1,2224.5,0.49851221013749225,-1.004299253675973,0.008046158334692837,2.0944114255049002,0.09409499402923192,1.0264334809650026,625]
["Q9BY50","Signal peptidase complex catalytic subunit SEC11C [OS=Homo sapiens]",33,7,57,7,192,21.5,9.2,140.87,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","SEC11C","ENSG00000166562","Protein export","SRP-dependent cotranslational protein targeting to membrane; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP); Synthesis, secretion, and deacylation of Ghrelin","",8431,8280.7,8439.5,7946.7,7965.9,9867.3,0.9756127836027294,-0.03561943277680769,0.7594292436242677,0.11951268333512244,0.8382163004605516,0.07664389786719904,6622]
["Q9BYD3","39S ribosomal protein L4, mitochondrial [OS=Homo sapiens]",40,8,16,8,311,34.9,9.72,64.08,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL4","ENSG00000105364","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1552.2,1838,1825.9,1558.3,1496.3,1885.4,1.0558906882591093,0.07846048652459635,0.5788875000176241,0.23740582810115346,0.706005128921878,0.15119214391366542,5993]
["Q9BYT3-1","Serine/threonine-protein kinase 33 [OS=Homo sapiens]",20,8,10,8,514,57.8,7.03,25.81,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction","nucleus;other cell component","kinase activity;other molecular function","STK33","ENSG00000130413","","","",703.5,721.8,682.2,643.6,667.5,778.5,1.0085662327718223,0.012305829170376172,0.8965994826179228,0.04740151607946852,0.9340429900875709,0.029633134553479688,7016]
["Q9BYV9","Transcription regulator protein BACH2 [OS=Homo sapiens]",2,1,1,1,841,92.5,5.1,2.39,"transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","BACH2","ENSG00000112182","","","",75.9,79.5,83,90.4,78.5,180.7,0.6819221967963386,-0.552320949038437,0.3155286662612396,0.5009611783104222,0.5333485249082794,0.272988901707722,4324]
["Q9BZ95","Histone-lysine N-methyltransferase NSD3 [OS=Homo sapiens]",4,4,5,1,1437,161.5,8.21,15.42,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","NSD3","ENSG00000147548","Lysine degradation; Metabolic pathways","PKMTs methylate histone lysines","",197,190.2,193.7,204.1,236.1,369.5,0.7174262072372483,-0.4790976476674312,0.20686211691612022,0.6843190352921035,0.44273944730305204,0.3538517814256819,3415]
["Q9BZF1-1","Oxysterol-binding protein-related protein 8 [OS=Homo sapiens]",33,24,60,22,889,101.1,6.96,152,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","OSBPL8","ENSG00000091039; ENSPTRG00000005242","","Acyl chain remodelling of PS","",5835.7,5846,5788.5,5497.1,5783,5543.6,1.0384279320244654,0.05440109512457945,0.07550832599340895,1.1220051578591628,0.2722695385721885,0.5650009446681985,2027]
["Q9BZF2","Oxysterol-binding protein-related protein 7 [OS=Homo sapiens]",6,4,6,4,842,95.4,8.05,24.38,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","OSBPL7","ENSG00000006025","","Synthesis of bile acids and bile salts","",414.2,387.5,398.6,367.7,397.5,401.4,1.0288873649922856,0.04108505525299366,0.441502869629755,0.35506646929973645,0.6066825482466403,0.21703849773634368,5319]
["Q9BZL4","Protein phosphatase 1 regulatory subunit 12C [OS=Homo sapiens]",36,18,25,1,782,84.8,5.57,76.28,"signal transduction;other biological processes","cytoskeleton;other cell component","enzyme regulator activity;other molecular function","PPP1R12C","ENSG00000125503","Vascular smooth muscle contraction; Focal adhesion; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Proteoglycans in cancer","","Focal adhesion",26.1,21.1,27.2,15.1,18.4,34.7,1.0909090909090908,0.12553088208385882,0.760886874942895,0.11867990727681477,0.8395715834779015,0.07594226916966552,6624]
["Q9BZQ6","ER degradation-enhancing alpha-mannosidase-like protein 3 [OS=Homo sapiens]",16,11,22,11,932,104.6,4.93,67.01,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","other molecular function","EDEM3","ENSG00000116406","Protein processing in endoplasmic reticulum","ER Quality Control Compartment (ERQC)","",1526.4,1614.4,1584.8,2068,2034.8,1794.4,0.8013294444821271,-0.3195326060530441,0.012257507329810815,1.9115978383799332,0.1153026011243079,0.9381608952968745,777]
["Q9C037-1","E3 ubiquitin-protein ligase TRIM4 [OS=Homo sapiens]",22,9,14,9,500,57.4,8.1,44.58,"protein metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","TRIM4","ENSG00000146833","","Antigen processing: Ubiquitination & Proteasome degradation; Negative regulators of DDX58/IFIH1 signaling; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; TRAF6 mediated IRF7 activation; TRAF6 mediated NF-kB activation; Ovarian tumor domain proteases; TRAF3-dependent IRF activation pathway","",1129,1224.1,1147,1044.8,994.2,1105.9,1.1129447677191644,0.15438199760812543,0.052935171410130044,1.2762556762869453,0.22759009872743557,0.6428466357812463,1700]
["Q9C0C9","(E3-independent) E2 ubiquitin-conjugating enzyme [OS=Homo sapiens]",34,34,79,34,1292,141.2,5.12,264.41,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","UBE2O","ENSG00000175931","Ubiquitin mediated proteolysis","Antigen processing: Ubiquitination & Proteasome degradation","",7261.5,7203.2,7435.9,7722.8,7565.1,7149.7,0.9760669590330515,-0.03494797358344403,0.3872786914398284,0.41197639778459566,0.5736967887583514,0.24131758105433992,4934]
["Q9C0J8","pre-mRNA 3' end processing protein WDR33 [OS=Homo sapiens]",23,22,38,22,1336,145.8,9.17,83.97,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","","WDR33","ENSG00000136709","mRNA surveillance pathway","mRNA Splicing - Major Pathway; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs","",2398.1,2311.2,2339.1,2987.3,3005.9,3473.9,0.7445152158527955,-0.42562676104163705,0.007489068507114511,2.1255721966366625,0.09062516840811252,1.0427511733738215,604]
["Q9GZM5","protein YIPF3 [OS=Homo sapiens]",13,3,4,3,350,38.2,5.76,17.57,"other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","","YIPF3","ENSG00000137207","","","",479.4,464.7,485.8,573.9,549.6,590.7,0.834150040835375,-0.26162118639722,0.0021489363460153,2.667776448623836,0.049547557580523115,1.3049777489576142,317]
["Q9GZS1-2","Isoform 2 of DNA-directed RNA polymerase I subunit RPA49 [OS=Homo sapiens]",32,10,21,10,419,47.2,8.94,68.24,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","POLR1E","ENSG00000137054","RNA polymerase","B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","Pyrimidine metabolism; Eukaryotic transcription initiation; Eukaryotic transcription initiation",1953.2,1945.3,1977.2,2302.3,2165.1,1466.7,0.990158575015588,-0.014268501949356409,0.9436725878966437,0.02517866029334018,0.9666857666344174,0.014714675860032993,7135]
["Q9GZT6","Coiled-coil domain-containing protein 90B, mitochondrial [OS=Homo sapiens]",28,8,18,8,254,29.5,7.55,45.98,"","other membranes;mitochondrion","","CCDC90B","ENSG00000137500","","","",1922.5,1805,1916.9,1435.1,1775.7,1504,1.1971663697293626,0.25962365696390194,0.04896567204148656,1.3101082805348734,0.2186255937392946,0.660298998062842,1637]
["Q9GZU8","Protein FAM192A [OS=Homo sapiens]",33,7,10,7,254,28.9,5.45,17.77,"other biological processes","nucleus","","PSME3IP1","ENSG00000172775","","","",1113.2,1226.5,1085.2,1528.8,1237.5,856.1,0.9454781360424027,-0.08088399830715312,0.7579697354741592,0.12034813470959609,0.8371110300061393,0.07721693564945736,6618]
["Q9GZY8-2","Isoform 2 of Mitochondrial fission factor [OS=Homo sapiens]",40,8,15,4,291,33,7.44,59.29,"","","","MFF","","","","",760.5,650.9,748.7,885.2,839.7,650.1,0.9095157894736844,-0.13682941116381353,0.4208207767268598,0.3759028263755227,0.5935505706477456,0.2265422731413558,5182]
["Q9H078-2","Isoform 2 of Caseinolytic peptidase B protein homolog [OS=Homo sapiens]",32,20,53,20,677,75.4,9.01,157.62,"","","","CLPB","","","","",4759.7,4982.2,5187.3,4931.5,4727,4304.6,1.0691895066281845,0.09651758368711132,0.2206229579744043,0.6563492969601239,0.454234704178851,0.34271968813124504,3550]
["Q9H0D6-1","5'-3' exoribonuclease 2 [OS=Homo sapiens]",43,33,111,33,950,108.5,7.47,358.53,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","XRN2","ENSG00000088930","Ribosome biogenesis in eukaryotes; RNA degradation","Major pathway of rRNA processing in the nucleolus and cytosol; Association of TriC/CCT with target proteins during biosynthesis","mRNA processing",10558,10220.9,10430.4,10274.4,11030.1,12195,0.9316348005194107,-0.10216356354054897,0.24954364956179617,0.6028534776726809,0.47947280090619565,0.3192360240540843,3804]
["Q9H0H0","integrator complex subunit 2 [OS=Homo sapiens]",9,7,9,7,1204,134.2,6.05,30.57,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","","INTS2","ENSG00000108506","","RNA polymerase II transcribes snRNA genes","",644.7,694.8,666.7,753.6,728.6,945.9,0.826242741238005,-0.2753624026705834,0.11553134009731994,0.9373001890613472,0.3379025869433019,0.47120848330382425,2499]
["Q9H0K6","Pseudouridylate synthase 7 homolog-like protein [OS=Homo sapiens]",9,5,10,5,701,80.6,7.56,31.67,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","PUS7L","ENSG00000129317","","","",665.4,746.9,719.9,896.2,977.3,1128.3,0.7103071490439069,-0.4934850891689628,0.01586521905366142,1.7995539271475822,0.12798994046712064,0.8928241629404224,906]
["Q9H0U3","Magnesium transporter protein 1 [OS=Homo sapiens]",17,8,25,8,335,38,9.63,56.67,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","transporter activity","MAGT1","ENSG00000102158","","Neutrophil degranulation; Maturation of spike protein; Miscellaneous transport and binding events; Asparagine N-linked glycosylation","",2955.3,2918.2,2921.8,2494.9,2499.4,4648,{"$f":"AVERAGE(S5890:U5890)/AVERAGE(V5890:X5890)","v":0.9121578876409155},{"$f":"LOG(Y5890,2)","v":-0.13264452926751147},{"$f":"TTEST(V5890:X5890,S5890:U5890,2,2)","v":0.7138576042630775},0.1463884098628635,{"$f":"AA5890*7309/AE5890","v":0.8043140480281846},0.09457434590911722,6487]
["Q9H0U4","ras-related protein Rab-1B [OS=Homo sapiens]",83,15,110,6,201,22.2,5.73,318.85,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","RAB1B","ENSG00000174903","Legionellosis","COPI-mediated anterograde transport; COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs; COPI-dependent Golgi-to-ER retrograde traffic; RAB geranylgeranylation; Golgi Cisternae Pericentriolar Stack Reorganization","",6051.1,5871.4,5932.2,4986.7,5698.4,5384,1.1111201000678321,0.15201476488879448,0.04880970582755762,{"$f":"-LOG10(AA5891)","v":1.3114938097959157},0.21886511649915255,{"$f":"-LOG10(AC5891)","v":0.6598234523159006},1630]
["Q9H115","Beta-soluble NSF attachment protein [OS=Homo sapiens]",35,8,33,5,298,33.5,5.47,97.76,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","other membranes;other cytoplasmic organelle;other cell component","other molecular function","NAPB","ENSG00000125814","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Retrograde transport at the Trans-Golgi-Network; Intra-Golgi traffic; COPII-mediated vesicle transport","",489.2,510.2,527.4,523.8,508.8,368.9,1.0894042097752408,0.12353934729570187,0.4550611092921714,0.3419302788454402,0.6145679319690467,0.2114301048870526,5412]
["Q9H1A4","anaphase-promoting complex subunit 1 [OS=Homo sapiens]",7,9,20,9,1944,216.4,6.3,56.12,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","ANAPC1","ENSG00000153107","Cell cycle; Oocyte meiosis; Ubiquitin mediated proteolysis; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection","Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Cyclin B; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Inactivation of APC/C via direct inhibition of the APC/C complex; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Cell cycle",1231.9,1311,1257.7,1327.7,1224.9,1026.8,1.061798066715092,0.08650941976783165,0.46471126942439733,0.3328167955876566,0.6217416562736445,0.2063900342182661,5463]
["Q9H1C4","Protein unc-93 homolog B1 [OS=Homo sapiens]",12,6,36,6,597,66.6,6.96,84.38,"stress response;transport;signal transduction;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding","UNC93B1","ENSG00000110057","","Trafficking and processing of endosomal TLR; UNC93B1 deficiency - HSE","",2983.4,2912.9,2895.3,3008.8,2941.4,2004,1.105277714917905,0.14440891042707346,0.43935190658488693,0.3571874846206373,0.6046362427469287,0.21850582415580158,5311]
["Q9H1K1","Iron-sulfur cluster assembly enzyme ISCU, mitochondrial [OS=Homo sapiens]",20,4,6,4,167,18,9.48,17.48,"cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","ISCU","ENSG00000136003","","","",731.9,754.1,786.2,790.5,885.1,428.7,1.0797890034690871,0.11074942962216597,0.709690213719196,0.14893118343823297,0.8013480259653335,0.09617882857219041,6473]
["Q9H246","Uncharacterized protein C1orf21 [OS=Homo sapiens]",11,1,1,1,121,13.9,5.22,4.29,"","","","C1orf21","ENSG00000116667","","","",79.9,66.5,63,68.1,80.8,43.2,1.0900572618427904,0.12440392326528153,0.6606957159095426,0.17999850923962782,0.7646912094351301,0.1165139022470044,6315]
["Q9H269","Vacuolar protein sorting-associated protein 16 homolog [OS=Homo sapiens]",18,12,37,12,839,94.6,6.77,104.51,"cell organization and biogenesis;other metabolic processes;transport","other membranes;other cytoplasmic organelle;other cell component","cytoskeletal activity","VPS16","ENSG00000215305","Salmonella infection","","Ebola virus pathway in host; Network map of SARS-CoV-2 signaling pathway",3234.2,3335.7,3256.5,3141.1,3008.9,3178,1.0534305317324184,0.07509517905354776,0.050063560836939684,1.30047826386012,0.2212300883658961,0.6551558071926749,1654]
["Q9H2G9-1","Golgin-45 [OS=Homo sapiens]",3,1,1,1,400,44.9,8.54,2.25,"cell organization and biogenesis;transport","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","BLZF1","ENSG00000117475","","Golgi Cisternae Pericentriolar Stack Reorganization","",57.8,57.4,62.9,102.7,107.5,61.2,0.6562269712601327,-0.607733204317235,0.10357871826886636,0.9847294674463611,0.31889505131724694,0.4963522201809606,2374]
["Q9H2H8-1","peptidyl-prolyl cis-trans isomerase-like 3 [OS=Homo sapiens]",39,7,18,7,161,18.1,6.79,51.85,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","CLK1; LOC111141199; PPIL3","ENSAMEG00000005917; ENSCAFG00000011929; ENSECAG00000019985; ENSFCAG00000005373; ENSG00000240344; ENSGGOG00000022268; ENSOCUG00000010661; ENSPPAG00000039183; ENSPPYG00000013062; ENSPTRG00000012793; ENSRFEG00010017851; ENSSSCG00000016096; ENSSSCG00070023158; ENSSSUG00005004462; ENSSTOG00000028255; ENSUMAG00000021460","","mRNA Splicing - Major Pathway; mRNA Splicing - Major Pathway","mRNA Processing",1365.8,1339.4,1284,1325.5,1363.2,1218.6,1.0209607657461677,0.029927426302868564,0.6110723420461442,0.21390737258612819,0.7287204679417961,0.13743903205426525,6129]
["Q9H2P9-1","Diphthine methyl ester synthase [OS=Homo sapiens]",15,4,8,4,285,31.6,5.31,21.24,"protein metabolism;other metabolic processes","cytosol","other molecular function","DPH5","ENSG00000117543; ENSPPAG00000030165; ENSPTRG00000001012","","Synthesis of diphthamide-EEF2","",1129.7,1178.9,1157.3,1197.2,1096.9,675.4,1.1671661895942078,0.22300999706338606,0.36080264083188923,0.4427302923758834,0.5597763748334278,0.2519854347301441,4711]
["Q9H329","Band 4.1-like protein 4B [OS=Homo sapiens]",1,1,2,1,900,99.7,9.04,2.25,"cell organization and biogenesis;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity","EPB41L4B","ENSG00000095203","Tight junction","","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway",167.7,162.5,179.4,167.3,146,167.2,1.0605619146722165,0.08482884659518769,0.3258165204881047,0.4870268986189104,0.5384112476254934,0.26888587610454123,4423]
["Q9H3E2","Sorting nexin-25 [OS=Homo sapiens]",3,3,4,3,840,97.9,6.38,7.29,"other metabolic processes;transport;other biological processes","other membranes;other cytoplasmic organelle;other cell component","other molecular function","SNX25","ENSG00000109762","","","",430.5,431.8,421.7,407.3,419.9,337.7,1.1022405356682976,0.14043908938003163,0.19808065931462862,0.7031579271014718,0.4332051283454879,0.3633064107748714,3342]
["Q9H3P2-1","Negative elongation factor A [OS=Homo sapiens]",38,14,42,14,528,57.2,9.03,144.18,"developmental processes;other biological processes","cytosol;nucleus","other molecular function","NELFA","ENSG00000185049","","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat","Initiation of transcription and translation elongation at the HIV-1 LTR",3329.4,3133.8,3152.3,4012.5,4100.4,4799.8,0.7446544874425952,-0.425356910759185,0.012842919094687029,1.8913362533209526,0.11718963253816166,0.9311108075212172,801]
["Q9H3S7","Tyrosine-protein phosphatase non-receptor type 23 [OS=Homo sapiens]",20,27,56,27,1636,178.9,6.92,172.73,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PTPN23","ENSG00000076201","","Interleukin-37 signaling","",5675.7,5625,5743.4,5749.2,5574.5,7359.2,0.9122834249500879,-0.13244598952559117,0.3914441740596969,0.40733016624099455,0.5769440347252116,0.23886631264813157,4959]
["Q9H3Z4","DnaJ homolog subfamily C member 5 [OS=Homo sapiens]",32,5,14,5,198,22.1,5.07,43.26,"cell-cell signaling;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","DNAJC5","ENSG00000101152","Protein processing in endoplasmic reticulum","Neutrophil degranulation; Sensory processing of sound by inner hair cells of the cochlea; GABA synthesis, release, reuptake and degradation","",1954.2,2019.5,2036.7,1614.8,1876,979.2,1.344608501118568,0.427186175969345,0.12732453775204372,0.8950878918421521,0.35317459067540324,0.4520105495067446,2635]
["Q9H488-1","GDP-fucose protein O-fucosyltransferase 1 [OS=Homo sapiens]",9,2,8,2,388,43.9,8.53,26.45,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","POFUT1","ENSG00000101346; ENSPTRG00000013375","Other types of O-glycan biosynthesis","Pre-NOTCH Processing in the Endoplasmic Reticulum","Delta-Notch signaling pathway",385.1,405,392.5,391.9,368.3,277,1.1401851137678365,0.18926807091134734,0.24406283980446636,0.6124983397814966,0.47379954744511144,0.324405358434243,3765]
["Q9H490","Phosphatidylinositol glycan anchor biosynthesis class U protein [OS=Homo sapiens]",11,4,7,4,435,50,7.72,24.74,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;ER/Golgi","","PIGU","ENSG00000101464","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways","Attachment of GPI anchor to uPAR","",976.2,1026.4,1011.2,852,868.4,995.1,1.1098508561959124,0.15036581758142256,0.10493218164957961,0.9790912976080225,0.32063098481470625,0.49399451104042275,2392]
["Q9H4G0-1","Band 4.1-like protein 1 [OS=Homo sapiens]",39,26,63,4,881,98.4,5.62,181.92,"cell organization and biogenesis","plasma membrane;other membranes;cytosol;cytoskeleton","cytoskeletal activity;other molecular function","EPB41L1","ENSG00000088367","","Neurexins and neuroligins; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Trafficking of AMPA receptors","Splicing factor NOVA regulated synaptic proteins",5671.1,5612,5472.1,5075.6,4925,4842.4,1.1288284039614633,0.1748261950843014,2.1185261068259373E-3,2.6739661797722274,0.04915653115806595,1.3084187716778548,315]
["Q9H4K7","Mitochondrial ribosome-associated GTPase 2 [OS=Homo sapiens]",9,2,2,2,406,43.9,9.45,8.88,"other biological processes","other membranes;mitochondrion;translational apparatus","other molecular function","MTG2","ENSG00000101181","","","",57.9,62.1,46.6,60,63.9,79.5,0.8190757128810227,-0.2879312784919524,0.17927072981048023,0.7464906135024798,0.4130800013192938,0.383965830264073,3172]
["Q9H4L7","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 [OS=Homo sapiens]",6,5,11,5,1026,117.3,5.55,27.98,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SMARCAD1","ENSG00000163104","Signaling pathways regulating pluripotency of stem cells","","",799.7,787.1,768.7,1003.2,946.8,655.6,0.9040144304574762,-0.14558229284061983,0.48354017086452916,0.31556744038118256,0.635646602310943,0.19678427007926708,5560]
["Q9H583","HEAT repeat-containing protein 1 [OS=Homo sapiens]",15,31,81,31,2144,242.2,6.54,202.7,"RNA metabolism OR transcription;other metabolic processes;other biological processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity","HEATR1","ENSG00000119285","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",7311.1,7367.4,7337,8149,7697.9,6891.1,0.968224997801038,-0.04658575245679163,0.5488507011494805,0.26054577665192485,0.6833985987566531,0.1653259160155663,5870]
["Q9H5X1-1","MIP18 family protein FAM96A [OS=Homo sapiens]",28,4,10,4,160,18.3,4.88,28.37,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","CIAO2A","ENSCANG00000036332; ENSCATG00000033389; ENSG00000166797; ENSGGOG00000016550; ENSMFAG00000035924; ENSMLEG00000042755; ENSMMUG00000014004; ENSPANG00000016877; ENSPPAG00000026013; ENSPTRG00000007153; ENSRBIG00000030155; ENSRROG00000031571","","","",597.9,569.3,589.8,663.9,698.2,1075.6,0.7207613734257702,-0.4724063976375296,0.16114933810637846,0.7927714739390359,0.3928754210205204,0.40574514056732364,2998]
["Q9H6A0-1","DENN domain-containing protein 2D [OS=Homo sapiens]",5,2,3,2,471,53.6,7.64,9.16,"","cytosol;nucleus","enzyme regulator activity","DENND2D","ENSG00000162777; ENSPPAG00000037282","","RAB GEFs exchange GTP for GDP on RABs","",108.2,123.9,118.1,116.3,116.6,260.3,0.7100567721005678,-0.4939937159692811,0.37839836852101405,0.42205074474341714,0.568725822644477,0.24509705242762153,4863]
["Q9H6K1","Uncharacterized protein C6orf106 [OS=Homo sapiens]",7,1,2,1,298,32.9,4.58,4.76,"other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","ILRUN","ENSG00000196821","","","",199.9,189.4,185.5,207.4,240.5,224.8,0.8544670729894455,-0.22690319637401818,0.03575784113296422,1.4466287094606665,0.18522612391271118,0.7322977613310414,1411]
["Q9H6P5","Threonine aspartase 1 [OS=Homo sapiens]",12,3,3,3,420,44.4,7.75,6.42,"protein metabolism;other metabolic processes;other biological processes","other cell component","other molecular function","TASP1","ENSG00000089123","","","",167.2,179.4,168.7,142.6,141.7,177.4,1.1160927008880226,0.1584568601036626,0.2219763736606577,0.6536932477783913,0.45509826510119133,0.34189482008230276,3565]
["Q9H6U8","Alpha-1,2-mannosyltransferase ALG9 [OS=Homo sapiens]",6,3,6,3,611,69.8,8.68,22.32,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","ALG9","ENSG00000086848","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG9 causes CDG-1l","",626,615.4,606.5,510.2,559.4,731.2,1.026155042203465,0.03724872482349286,0.8268074137241929,0.08259563784413002,0.8863501594177362,0.05239467285302943,6818]
["Q9H788","SH2 domain-containing protein 4A [OS=Homo sapiens]",22,8,14,8,454,52.7,8.06,29.96,"other biological processes","cytosol;other cell component","other molecular function","SH2D4A","ENSG00000104611","","","",1409,1386.4,1440.9,1698.6,1802.6,2046,0.7636825785982118,-0.3889549820712672,0.013744326144093487,1.8618765478594896,0.12059697453442891,0.9186635873823044,833]
["Q9H7B4-1","Histone-lysine N-methyltransferase SMYD3 [OS=Homo sapiens]",7,2,9,2,428,49.1,7.25,19.06,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","SMYD3","ENSG00000185420","Lysine degradation; Metabolic pathways","PKMTs methylate histone lysines","Histone modifications",353.2,388.6,438,385.1,294.4,389.4,1.1037515202544672,0.14241542497414472,0.40285855064928017,0.3948474140470161,0.5829525136993841,0.23436682067539272,5051]
["Q9H7P6","Multivesicular body subunit 12B [OS=Homo sapiens]",7,1,1,1,319,35.6,8.15,4.5,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MVB12B","ENSG00000196814","Endocytosis","Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Late endosomal microautophagy","",51.2,45.6,49.4,44.7,30.3,24.9,1.4634634634634636,0.5493867281600191,0.06567707887396597,1.1825861716183594,0.2530489032629506,0.5967955406230491,1897]
["Q9H832","Ubiquitin-conjugating enzyme E2 Z [OS=Homo sapiens]",21,7,11,7,354,38.2,5.62,28.13,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","enzyme regulator activity;other molecular function","UBE2Z","ENSG00000159202","Ubiquitin mediated proteolysis","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation","",1912.4,1953.9,1986.4,1933.4,1888.7,943.2,1.228191299603383,0.296535288309503,0.3253562563540191,0.4876408376963672,0.5378938877384133,0.2693033907182683,4421]
["Q9H871-1","Protein RMD5 homolog A [OS=Homo sapiens]",19,4,10,4,391,44,6.06,36.75,"protein metabolism;other metabolic processes","nucleus;other cell component","other molecular function","LOC111148095; RMD5A; Rmnd5a; RMND5A","ENSAMEG00000009979; ENSBIXG00000016128; ENSBIXG00005012781; ENSBMUG00000001433; ENSBTAG00000021140; ENSCANG00000000502; ENSCATG00000002310; ENSCHIG00000026499; ENSCPOG00000038199; ENSCSAG00000016355; ENSDLEG00000016828; ENSECAG00000020001; ENSG00000153561; ENSHGLG00000004880; ENSLCNG00005014561; ENSMFAG00000065825; ENSMMNG00015005282; ENSMMUG00000003523; ENSMNEG00000044699; ENSMPUG00000009296; ENSMUSG00000002222; ENSNVIG00000017991; ENSOARG00000020715; ENSOCUG00000009371; ENSOGAG00000007229; ENSPANG00000005829; ENSPCOG00000015308; ENSPCTG00005006099; ENSPPYG00000012209; ENSPTRG00000050213; ENSRBIG00000033920; ENSRNOG00000028422; ENSRROG00000038497; ENSSSCG00000035478; ENSSSCG00070028877; ENSSSUG00005017842","","","Ciliary landscape",429.4,438.2,412.2,376.5,427.2,314.8,1.1442109968708092,0.19435311511524658,0.18256253972173375,0.7385883311891034,0.41607408881389213,0.3808293292335709,3207]
["Q9H8M1","Coenzyme Q-binding protein COQ10 homolog B, mitochondrial [OS=Homo sapiens]",3,1,1,1,238,27.1,9.6,2.4,"other metabolic processes","other membranes;mitochondrion","other molecular function","COQ10B","ENSG00000115520","","Respiratory electron transport","",101.9,99.2,108.1,112.2,120.4,189.9,{"$f":"AVERAGE(S6082:U6082)/AVERAGE(V6082:X6082)","v":0.7318343195266273},{"$f":"LOG(Y6082,2)","v":-0.4504110221320616},{"$f":"TTEST(V6082:X6082,S6082:U6082,2,2)","v":0.20227996388214067},0.694047132584423,{"$f":"AA6082*7309/AE6082","v":0.43793372512279805},0.3585916086540674,3376]
["Q9H8T0-1","AKT-interacting protein [OS=Homo sapiens]",11,3,4,3,292,33.1,9.31,11.58,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","AKTIP; FTS","ENSCSAG00000005299; ENSG00000166971; ENSGGOG00000014821; ENSMNEG00000035738; ENSNLEG00000031116; ENSPANG00000018701; ENSPTRG00000008116; ENSRROG00000038050; ENSSBOG00000028267","","","",450.5,424.3,452.6,486.9,446.2,359.6,1.026843041695676,0.03821567506128229,0.7795003451113265,0.10818368819815227,0.851624517551373,0.0697518440820024,6690]
["Q9H936","Mitochondrial glutamate carrier 1 [OS=Homo sapiens]",7,2,6,2,323,34.4,9.29,22.94,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","SLC25A22","ENSG00000177542","","Organic anion transporters","",1180.3,1369.1,1317.9,1191.8,1113.2,1792.1,0.9439115471919162,-0.08327642217153584,0.7471053169314,0.12661817283225765,0.8286180214645832,0.08164562554229451,6590]
["Q9H999","Pantothenate kinase 3 [OS=Homo sapiens]",13,4,9,2,370,41.1,6.55,21.39,"other metabolic processes","cytosol;nucleus","kinase activity;other molecular function","PANK3","ENSG00000120137","Pantothenate and CoA biosynthesis; Metabolic pathways; Biosynthesis of cofactors","Coenzyme A biosynthesis","",52.6,46.4,49.1,71.6,68,60.3,0.7408704352176089,-0.4327068314557798,0.01032753298303276,1.9860034093432668,0.10601676765868882,0.9746254410961502,712]
["Q9H9A7","RecQ-mediated genome instability protein 1 [OS=Homo sapiens]",7,3,3,3,625,70.1,4.96,10.08,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","nucleus;other cell component","other molecular function","RMI1","ENSG00000178966","Fanconi anemia pathway","Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function","",108.6,114.4,114.9,114.5,121,189,0.7959952885747938,-0.32916820327659935,0.29381535826491667,0.5319255065873719,0.5158530995816181,0.28747395559017636,4163]
["Q9H9J4-1","Ubiquitin carboxyl-terminal hydrolase 42 [OS=Homo sapiens]",2,2,2,2,1324,145.3,8.63,5.63,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","USP42","ENSG00000106346","","Ub-specific processing proteases","",58.3,46,52.9,63.8,67.5,198.3,0.4769417475728155,-1.068115024924612,0.26498030518847704,0.576786404047437,0.49218324031069344,0.3078731788585474,3935]
["Q9H9T3","elongator complex protein 3 [OS=Homo sapiens]",20,10,24,10,547,62.2,8.88,76.04,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","ELP3","ENSG00000134014","","HATs acetylate histones","Ethanol effects on histone modifications",2338.1,2341,2347.8,2721.4,2688.5,2101,0.935560319003049,-0.09609742258517405,0.4683102770769535,0.329466311513591,0.6246131049553746,0.20438890811398727,5480]
["Q9HA64","Ketosamine-3-kinase [OS=Homo sapiens]",28,8,20,8,309,34.4,7.33,43.08,"protein metabolism;other metabolic processes","cytosol","kinase activity;other molecular function","FN3KRP","ENSG00000141560","","Gamma carboxylation, hypusine formation and arylsulfatase activation","",2315.6,2214.7,2234,2250.9,2219.8,3886.1,0.8094366264598888,-0.3050099634281807,0.3900521040898726,0.40887737500615917,0.5754725128770446,0.2399754153720044,4954]
["Q9HAF1","Chromatin modification-related protein MEAF6 [OS=Homo sapiens]",18,2,3,2,191,21.6,9.32,11.04,"protein metabolism;other metabolic processes","nucleus;other cell component","","MEAF6","ENSG00000163875","","HATs acetylate histones; Regulation of TP53 Activity through Acetylation","",27.7,35.7,37.3,31,43.9,80.8,0.6467565831727682,-0.6287052610722522,0.2946268980679225,0.5307276066135009,0.516533460776792,0.2869015398558254,4169]
["Q9HAP2-1","MLX-interacting protein [OS=Homo sapiens]",2,1,1,1,919,101.1,8.35,0,"other biological processes","other membranes;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","MLXIP","ENSG00000175727; ENSG00000281178","Insulin resistance; Non-alcoholic fatty liver disease","","Nonalcoholic fatty liver disease",17.7,17.8,17.5,22.4,16.8,27.4,0.7957957957957958,-0.32952981762070055,0.2129498784498352,0.6717226034821361,0.4482864808726514,0.3484443581026174,3472]
["Q9HAW4","Claspin [OS=Homo sapiens]",1,1,1,1,1339,151,4.82,2.74,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","ER/Golgi;nucleus","nucleic acid binding activity;other molecular function","CLSPN","ENSG00000092853","","Ub-specific processing proteases; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Apoptotic cleavage of cellular proteins","",12.8,17.4,17.1,21.7,21,56.1,0.478744939271255,-1.0626708582452826,0.2155705996130374,0.6664104702779184,0.45068807567840113,0.34612393235631095,3496]
["Q9HB90","ras-related GTP-binding protein C [OS=Homo sapiens]",34,9,14,5,399,44.2,5.1,41.02,"RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RRAGC","ENSG00000116954","Autophagy; mTOR signaling pathway; Shigellosis","Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Macroautophagy; mTORC1-mediated signalling; Amino acids regulate mTORC1; Energy dependent regulation of mTOR by LKB1-AMPK","Target of rapamycin (TOR) signaling",1364.7,1549.6,1480.3,1354.1,1175,810.3,1.3159849074684078,0.396142943445996,0.10564299310293986,0.9761593027540572,0.32186104067919447,0.4923315888379147,2399]
["Q9HBH5","Retinol dehydrogenase 14 [OS=Homo sapiens]",34,9,27,9,336,36.8,8.79,85.2,"other metabolic processes","other membranes;cytosol;ER/Golgi;nucleus","other molecular function","RDH14","ENSG00000240857","","RA biosynthesis pathway","",2680.6,2767.1,2743.3,2603.7,2663.9,2761.4,1.0201768588865363,0.028819280942296886,0.3633905384871616,0.4396263845026937,0.5608153390630625,0.2511801163335841,4736]
["Q9HBR0","Putative sodium-coupled neutral amino acid transporter 10 [OS=Homo sapiens]",16,16,33,16,1119,119.7,5.73,90.23,"transport;developmental processes","other membranes;ER/Golgi","transporter activity","SLC38A10","ENSG00000157637","","","",4138.3,4001.3,4037.3,4051.9,4349.2,5987.7,0.8462762704325588,-0.24079938081182614,0.2887303277058089,0.539507596224855,0.5122160109713003,0.29054685037401673,4120]
["Q9HC52","chromobox protein homolog 8 [OS=Homo sapiens]",22,7,17,7,389,43.4,9.91,39.61,"protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","CBX8","ENSG00000141570","","SUMOylation of DNA damage response and repair proteins; SUMOylation of RNA binding proteins; SUMOylation of chromatin organization proteins; SUMOylation of transcription cofactors; Oxidative Stress Induced Senescence; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN gene transcription","",1052.8,1116.1,980,1282.9,1176.7,1419.3,0.8118023150893292,-0.3007996405833008,0.039018650146300085,1.4087277591381573,0.19374138173865987,0.7127776072556644,1472]
["Q9HCC9-1","Lateral signaling target protein 2 homolog [OS=Homo sapiens]",6,3,3,3,887,96.4,5.11,10.56,"other biological processes","other membranes;cytosol;other cytoplasmic organelle","other molecular function","ZFYVE28","ENSG00000159733","","","",40,51.3,56,53.8,46.8,81.2,0.8102310231023102,-0.3035947691582579,0.37465710568477373,0.42636602623037156,0.5681263040352721,0.24555510258524813,4820]
["Q9HCJ1","progressive ankylosis protein homolog [OS=Homo sapiens]",5,2,5,2,492,54.2,7.88,10.25,"transport;developmental processes;other biological processes","plasma membrane;other membranes","transporter activity","ANKH","ENSG00000154122","","Miscellaneous transport and binding events","",428.8,411.7,438.7,412.9,399.6,276.7,1.1744399559309586,0.23197295643653618,0.22400960113065677,0.6497333672519747,0.45606857232979675,0.3409698539463209,3590]
["Q9HCK8-1","Chromodomain-helicase-dna-binding protein 8 [OS=Homo sapiens]",5,11,13,5,2581,290.3,6.47,32.73,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CHD8","ENSG00000100888","Wnt signaling pathway","Deactivation of the beta-catenin transactivating complex","lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Malignant pleural mesothelioma",938.9,976.6,930.3,1070.5,1104.5,947.3,0.9114434871729175,-0.1337748882147568,0.13801848105805906,0.8600627564672844,0.3647061019715668,0.4380569703566032,2766]
["Q9HD26-1","Golgi-associated PDZ and coiled-coil motif-containing protein [OS=Homo sapiens]",18,8,12,8,462,50.5,5.92,36.97,"transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","GOPC","ENSG00000047932","","RHOQ GTPase cycle; RHO GTPases regulate CFTR trafficking","",1646.6,1689.3,1729.4,2322.7,2081.8,2007.2,0.7900088899979725,-0.34005920680796997,0.010243096862681267,1.9895687204071257,0.10619403541749983,0.9738998755145515,705]
["Q9HDC9","Adipocyte plasma membrane-associated protein [OS=Homo sapiens]",50,18,71,18,416,46.5,6.16,226.63,"other metabolic processes","other membranes;other cell component","other molecular function","APMAP","ENSG00000101474","","","Ciliary landscape",10193.4,10400.5,10598.1,9063.3,9090.1,9211.9,1.139837677642854,0.18882838725528403,5.2716442743577557E-4,3.278053903212186,0.024699005129026175,1.6073205396826746,156]
["Q9NNX1","tuftelin [OS=Homo sapiens]",5,2,2,2,390,44.2,6,2.63,"developmental processes;signal transduction","non-structural extracellular;other cell component","extracellular structural activity;bone, tooth or skin structural activity","TUFT1","ENSG00000143367","","","",234.6,205.5,229.2,214.6,225.7,605.2,0.6401721664275466,-0.643468142511645,0.3850531047363703,0.41447937048236166,0.572372003766144,0.24232161688855022,4917]
["Q9NP80-1","Calcium-independent phospholipase A2-gamma [OS=Homo sapiens]",8,6,10,5,782,88.4,9.23,22.81,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle","other molecular function","IPLA2(GAMMA); PNPLA8","ENSG00000135241","","Acyl chain remodelling of PC; Acyl chain remodelling of PE","Eicosanoid synthesis",813.2,839.6,877.8,783.9,762.1,313.4,1.3609766591373562,0.4446423247143997,0.2210863224886754,0.6554381242301142,0.4542929241129403,0.34266402753192143,3557]
["Q9NPF5","DNA methyltransferase 1-associated protein 1 [OS=Homo sapiens]",14,6,7,6,467,53,9.5,18.39,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","DMAP1","ENSG00000178028","","HATs acetylate histones","",465.8,470.3,494.7,591.5,574.2,645.8,0.7898426718189345,-0.3403627823454245,0.00557394542206748,2.253837288046642,0.077452408916143,1.110965070316408,526]
["Q9NPI1-1","Bromodomain-containing protein 7 [OS=Homo sapiens]",30,17,35,17,651,74.1,6.39,99.61,"cell-cell signaling;cell cycle OR cell proliferation;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","BRD7","ENSG00000166164","Hepatocellular carcinoma","Regulation of TP53 Activity through Acetylation","",2849.7,2695.6,2684.7,3309.3,3424.7,3028.7,0.8430044967068536,-0.24638776815728147,0.016710121731832946,1.7770203862962703,0.13175218957709495,0.8802421585567944,927]
["Q9NPR2-1","Semaphorin-4B [OS=Homo sapiens]",1,1,1,1,832,92.1,6.95,2.25,"","","","","","","","",127.2,147,133.6,138.9,148.4,239.4,0.7742547940003794,-0.36911968413736085,0.29042777733722563,0.5369618488281256,0.5133583130732242,0.28957940083271805,4135]
["Q9NQ25-7","Isoform 7 of SLAM family member 7 [OS=Homo sapiens]",32,4,13,1,188,21.3,6.02,48.57,"","","","SLAMF7","","","","",47.1,57.8,49.4,18.6,19.7,31.5,2.210601719197708,1.1444391203610829,5.8491548812515705E-3,2.2329068786909865,0.07946370451127831,1.0998311924734028,538]
["Q9NQ88","Fructose-2,6-bisphosphatase TIGAR [OS=Homo sapiens]",23,5,11,5,270,30,7.69,35.58,"other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","other molecular function","TIGAR","ENSG00000078237","Fructose and mannose metabolism; Metabolic pathways; Central carbon metabolism in cancer","TP53 Regulates Metabolic Genes","Genotoxicity pathway; Metabolic reprogramming in colon cancer; p53 transcriptional gene network",1019.6,1007.3,1024.7,920.3,915.5,556.2,1.2757525083612042,0.3513484783257953,0.14257534563847057,0.8459555669026074,0.3711122511650931,0.43049470847640214,2808]
["Q9NQL2-1","Ras-related GTP-binding protein D [OS=Homo sapiens]",13,5,8,1,400,45.6,4.92,24.01,"stress response;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RRAGD","ENSG00000025039; ENSGGOG00000024195; ENSNLEG00000013157; ENSPPAG00000029815; ENSPTRG00000018420","Autophagy; mTOR signaling pathway; Shigellosis","Amino acids regulate mTORC1; TP53 Regulates Metabolic Genes; Regulation of PTEN gene transcription; mTORC1-mediated signalling; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK","Target of rapamycin (TOR) signaling",43.5,46.8,56.9,43,32,65.6,1.0469416785206258,0.06618107698447748,0.846858417365173,0.07218919143642018,0.9009735331182022,0.04528796661199767,6870]
["Q9NQS7","Inner centromere protein [OS=Homo sapiens]",17,16,29,15,918,105.4,9.44,76.56,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity","INCENP","ENSG00000149503","","SUMOylation of DNA replication proteins; Separation of Sister Chromatids; RHO GTPases Activate Formins; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",2028.1,2008.1,1975,2085.4,2243.2,2064.1,0.94032255541477,-0.08877237078360697,0.09567976510709356,1.019179899543147,0.3071249025769639,0.5126849682743168,2277]
["Q9NQW7-3","Isoform 3 of Xaa-Pro aminopeptidase 1 [OS=Homo sapiens]",42,21,59,20,666,74.8,5.88,197.11,"","","","XPNPEP1","","","","",5605.1,5802.5,5785.8,5401.5,5392.6,5708.2,1.0418790108045548,0.05918775300336924,0.13079760673418755,0.8834002024310562,0.35645030112609133,0.4480010140626633,2682]
["Q9NR28-1","Diablo homolog, mitochondrial [OS=Homo sapiens]",32,8,22,7,239,27.1,5.9,68.42,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion","","DIABLO","ENSG00000184047","Apoptosis; Apoptosis","Regulation of the apoptosome activity; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Release of apoptotic factors from the mitochondria","TNF-alpha signaling pathway; Nanomaterial induced apoptosis; Apoptosis; Complement system in neuronal development and plasticity",2655.8,2613.5,2739.3,2696.4,2651.3,2392.3,1.0347028423772608,0.04921649778897879,0.428384950986538,0.3681657941854242,0.5978738985603602,0.22339040620293713,5237]
["Q9NR34","mannosyl-oligosaccharide 1,2-alpha-mannosidase IC [OS=Homo sapiens]",1,1,1,1,630,70.9,7.46,2.08,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","MAN1C1","ENSG00000117643","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum","Intra-Golgi traffic; Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2","",117.8,147.2,151.9,139.2,127.3,129.3,1.0533097524002022,0.07492975976087698,0.5669437560263297,0.2464600233980722,0.6972559166744816,0.1566077917723087,5943]
["Q9NRA0-1","Sphingosine kinase 2 [OS=Homo sapiens]",2,1,3,1,654,69.2,6.95,7.09,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","SPHK2","ENSG00000063176","Sphingolipid metabolism; Metabolic pathways; Calcium signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; VEGF signaling pathway; Apelin signaling pathway; Fc gamma R-mediated phagocytosis; Tuberculosis","Sphingolipid de novo biosynthesis","Sphingolipid pathway; S1P receptor signal transduction; Metabolism of spingolipids in ER and Golgi apparatus; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway",120.8,130,128.3,123.5,138.6,185.1,0.8477191413237924,-0.23834173167254605,0.29267988877723605,0.5336071186770545,0.5152209313759196,0.288006501633483,4152]
["Q9NRB3","carbohydrate sulfotransferase 12 [OS=Homo sapiens]",18,5,8,5,414,48.4,9.32,35.01,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","CHST12","ENSG00000136213","Glycosaminoglycan biosynthesis","Chondroitin sulfate biosynthesis","Metapathway biotransformation Phase I and II",654.6,668.5,632.9,825,830.8,681.3,0.8369346626160626,-0.2568130952886738,0.06386860471440833,1.194712571417592,0.24936732471026204,0.6031604539357054,1872]
["Q9NRG7-1","Epimerase family protein sdr39u1 [OS=Homo sapiens]",5,1,3,1,319,34.7,9.77,10.09,"","","","","","","","",137.2,147.4,136.3,120.2,107.4,127.8,1.1842993809791784,0.2440338283123772,0.034578589474501965,1.4611927263869784,0.18314123947038757,0.737213850904242,1380]
["Q9NRP0-1","oligosaccharyltransferase complex subunit OSTC [OS=Homo sapiens]",13,2,19,2,149,16.8,9.13,58.98,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","DC2; OSTC","ENSANAG00000024765; ENSCANG00000031432; ENSCATG00000035272; ENSCCAG00000023668; ENSCJAG00000042857; ENSG00000198856; ENSGGOG00000026873; ENSMFAG00000034553; ENSMLEG00000037144; ENSMMUG00000011902; ENSNLEG00000012929; ENSOGAG00000033684; ENSPANG00000016693; ENSPPAG00000043858; ENSPTRG00000024222; ENSRBIG00000031965; ENSRROG00000031431","","","",1480.5,1443,1411.1,1141.9,1183.3,1490.4,1.136020547227173,0.18398892913367298,0.19646040127172645,0.7067249732388627,0.4315987595115866,0.3649198122237122,3327]
["Q9NRR8","CDC42 small effector protein 1 [OS=Homo sapiens]",10,1,1,1,79,8.9,9.99,2.02,"transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","CDC42SE1","ENSG00000197622","","","",46.2,43,44.4,64.4,81.8,244.7,0.3417753901253518,-1.5488795768152386,0.20960987245379445,0.6785882662912017,0.4461381938744274,0.3505305952321265,3434]
["Q9NRX2","39S ribosomal protein L17, mitochondrial [OS=Homo sapiens]",9,2,4,2,175,20,10.11,9.19,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL17","ENSG00000158042","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",676.4,625.7,693.8,738.5,868.6,1117.5,0.7325478969390002,-0.44900500304219754,0.09812647764003062,1.0082137903630757,0.31034462357030884,0.5081557739582121,2311]
["Q9NS00-1","Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 [OS=Homo sapiens]",18,6,13,6,363,42.2,6.64,40.84,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","C1GALT1","ENSG00000106392","Mucin type O-glycan biosynthesis; Other types of O-glycan biosynthesis; Metabolic pathways","O-linked glycosylation of mucins; Defective C1GALT1C1 causes TNPS","Ectoderm differentiation",1123.2,1126.2,1131,1153.8,1181.2,3274.5,0.6026205544166147,-0.7306782131113226,0.3497660817774997,0.4562223080965719,0.551313412057741,0.25860144210840336,4637]
["Q9NS69","Mitochondrial import receptor subunit TOM22 homolog [OS=Homo sapiens]",63,5,47,5,142,15.5,4.34,200.86,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity","TOMM22","ENSG00000100216","","Mitochondrial protein import; PINK1-PRKN Mediated Mitophagy","",3447.1,3281.4,3305.7,2740,3276,3195.1,1.0893595770320592,0.1234802390640999,0.1912716340733753,0.7183494318484971,0.4253131650265592,0.37129117404614853,3287]
["Q9NSD4","zinc finger protein 275 [OS=Homo sapiens]",3,1,1,1,429,48.4,9.09,2.04,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF275","ENSG00000063587","","","",114.4,90.2,87.9,275.1,276.2,226.4,0.37610903947537616,-1.4107771140885668,9.391407355245024E-4,3.0272693213847592,0.03300086363436821,1.481474694463548,208]
["Q9NSG2-1","Uncharacterized protein C1orf112 [OS=Homo sapiens]",4,2,2,2,853,96.5,6,6.63,"","","","C1orf112","ENSG00000000460","","","",64.8,66.6,61.1,67.3,76.5,696.2,0.22916666666666663,-2.125530882083859,0.35828937106472314,0.44576607532930806,0.5581280931611384,0.2532661168888267,4692]
["Q9NSY1","BMP-2-inducible protein kinase [OS=Homo sapiens]",8,6,8,6,1161,129.1,6.51,19.35,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","BMP2K","ENSG00000138756","Transcriptional misregulation in cancer","","",748.1,687.9,694,777.9,781.7,678.7,0.9516150650046911,-0.071549983658656,0.40446356082688234,0.3931205990076084,0.5842340249177239,0.23341315396343454,5060]
["Q9NTN3","UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter [OS=Homo sapiens]",2,1,3,1,355,39.2,8.97,6.69,"transport","other membranes;ER/Golgi","transporter activity","SLC35D1","ENSG00000116704","","Formation of the active cofactor, UDP-glucuronate; Transport of nucleotide sugars; Defective SLC35D1 causes SCHBCKD","",367.7,317,327.5,327.3,320.9,389.7,0.9752384622796031,-0.03617306957955265,0.7655494018604599,0.11602677849528116,0.841287111441603,0.07505576444545885,6651]
["Q9NTX7","E3 ubiquitin-protein ligase rnf146 [OS=Homo sapiens]",9,3,3,3,359,38.9,5.33,4.98,"cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","RNF146","ENSG00000118518","","Degradation of AXIN; Ub-specific processing proteases; Regulation of PTEN stability and activity","",169.8,183.9,159.1,165.1,168,286.6,0.8274971760529289,-0.27317370635286875,0.43035219985253015,0.3661759726881589,0.5993605618754083,0.22231183717178976,5248]
["Q9NUL5","Repressor of yield of DENV protein [OS=Homo sapiens]",4,1,3,1,291,33.1,7.25,8.25,"stress response;other biological processes","cytosol;nucleus;other cell component","translation activity;nucleic acid binding activity;other molecular function","SHFL","ENSG00000130813","","","",324,327.7,300,306.5,323.5,516.2,0.8303088466236259,-0.2682800251587509,0.39312637563831365,0.4054678175131463,0.5776760513752381,0.23831563656309054,4974]
["Q9NUQ2","1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [OS=Homo sapiens]",35,12,28,12,364,42,9.1,77.29,"other metabolic processes;developmental processes","other membranes;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","AGPAT5","ENSG00000155189; ENSG00000284980","Glycerolipid metabolism; Glycerophospholipid metabolism; Metabolic pathways; Phospholipase D signaling pathway","Synthesis of PA","Triacylglyceride synthesis",3005.2,2877.5,2857.6,2689.9,2644.4,2252.9,1.1519796499367352,0.2041152313681858,0.05825696590330251,1.2346521377269957,0.23840994612947258,0.6226756303955503,1786]
["Q9NUQ3-1","Gamma-taxilin [OS=Homo sapiens]",22,10,16,9,528,60.5,7.52,45.14,"cell cycle OR cell proliferation;other biological processes","other membranes;cytosol;nucleus","other molecular function","TXLNG","ENSG00000086712","","","",1347.1,1391.9,1466.7,1844.5,1739.6,825.1,0.9538465027669417,-0.06817097489798435,0.8451517358495759,0.073065312202661,0.9003372740598382,0.045594769645099,6861]
["Q9NUU7","ATP-dependent RNA helicase DDX19A [OS=Homo sapiens]",49,21,55,4,478,53.9,6.58,145.47,"other metabolic processes;transport","nucleus;other cell component","nucleic acid binding activity;other molecular function","DDX19A","ENSG00000168872","Nucleocytoplasmic transport; mRNA surveillance pathway","","",7379.5,7352.3,7417.4,7095.5,7217,6640.4,1.05709472197166,0.08010465656548495,0.0867512702408043,1.061724157407023,0.2930060231931787,0.5331234519575818,2164]
["Q9NUY8","TBC1 domain family member 23 [OS=Homo sapiens]",16,8,13,8,699,78.3,5.41,44.18,"cell organization and biogenesis;transport;developmental processes","cytosol;ER/Golgi;other cell component","","TBC1D23","ENSG00000036054","","","",725.4,690.3,679.2,707,665.3,937,0.9071580132507683,-0.1405742265171392,0.45083289851977,0.34598439980365564,0.6120240815900815,0.21323148913560314,5384]
["Q9NV96","Cell cycle control protein 50A [OS=Homo sapiens]",24,7,26,7,361,40.7,8.59,87.23,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity","TMEM30A","ENSG00000112697","","Neutrophil degranulation","",2363.9,2442.8,2492.2,2430.2,2639.5,2131.8,1.0135249600777616,0.019381618491044562,0.84128158133965,0.07505861923857704,0.8977846514836475,0.046827823564501804,6849]
["Q9NVG8","TBC1 domain family member 13 [OS=Homo sapiens]",26,9,11,9,400,46.5,5.24,34.76,"transport;other biological processes","other membranes;cytosol","enzyme regulator activity;other molecular function","TBC1D13","ENSG00000107021","","TBC/RABGAPs","",1110.6,1028.3,1011.8,1000.8,1057,1085.8,1.0022585570683291,0.003254734961711579,0.955045180298315,0.01997608277214535,0.9732885140547106,0.011758401778317605,7172]
["Q9NVH2","Integrator complex subunit 7 [OS=Homo sapiens]",13,8,13,8,962,106.8,8.02,34.41,"RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","","INTS7","ENSG00000143493","","RNA polymerase II transcribes snRNA genes","",716.4,683.7,703.6,856.6,824.4,764.6,0.8601979064442263,-0.2172594748419633,0.01630311132180832,1.787729505967286,0.12980331225609698,0.8867142252845555,918]
["Q9NVM6","DnaJ homolog subfamily C member 17 [OS=Homo sapiens]",2,1,1,1,304,34.7,8.53,2.12,"transport;other biological processes","nucleus;other cell component","nucleic acid binding activity","DNAJC17","ENSG00000104129","","","",75.9,68,84.7,119.1,137.2,193.4,{"$f":"AVERAGE(S6402:U6402)/AVERAGE(V6402:X6402)","v":0.5083388925950635},{"$f":"LOG(Y6402,2)","v":-0.9761374804545373},{"$f":"TTEST(V6402:X6402,S6402:U6402,2,2)","v":0.0322576135197818},1.4913677656986917,{"$f":"AA6402*7309/AE6402","v":0.17820929494791019},0.7490696480022196,1323]
["Q9NVS2","39S ribosomal protein S18a, mitochondrial [OS=Homo sapiens]",18,3,8,3,196,22.2,10.33,26.3,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPS18A","ENSG00000096080","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",757.7,820.9,832.1,728.7,660.4,655.2,1.1792300542973144,0.237845199078485,0.02107058930605191,1.6763233177954364,0.14528767663955983,0.8377712211762338,1060]
["Q9NVS9","Pyridoxine-5'-phosphate oxidase [OS=Homo sapiens]",41,7,19,7,261,30,7.06,69.9,"other metabolic processes","cytosol","other molecular function","PNPO","ENSG00000108439","Vitamin B6 metabolism; Metabolic pathways; Biosynthesis of cofactors","Vitamins B6 activation to pyridoxal phosphate","Selenium micronutrient network; Vitamin B6-dependent and responsive disorders",2551.5,2328.6,2219.8,2697.9,3014.2,4712,0.6811043639259026,-0.5540522191428445,0.15488864139356057,0.8099804296324787,0.3873010879047329,0.41195128310594215,2923]
["Q9NVX7-1","Kelch repeat and BTB domain-containing protein 4 [OS=Homo sapiens]",5,2,2,2,518,58.1,5.67,7.11,"","","","KBTBD4","ENSG00000123444; ENSG00000284900","","","",41.7,55.9,44.4,55.2,50.6,73.6,0.7915273132664437,-0.3372889605272169,0.20600077168634448,0.6861311527449561,0.4416719390599858,0.35490019208987433,3409]
["Q9NW13-1","RNA-binding protein 28 [OS=Homo sapiens]",31,21,47,20,759,85.7,9.22,121.73,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity","RBM28","ENSG00000106344","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol","",5872.2,5859.5,6037.5,9041.4,8969.1,10863.1,0.6154133880084229,-0.7003722657702343,0.004007775050126527,2.3970966626973023,0.06718538495728162,1.1727251900819156,436]
["Q9NW82","WD repeat-containing protein 70 [OS=Homo sapiens]",26,16,25,16,654,73.2,6.33,58.75,"other biological processes","nucleus;other cell component","other molecular function","WDR70","ENSG00000082068","","","",2591.2,2656.8,2610.9,2913.7,2924.1,3248.1,0.8649555905303823,-0.20930203261928962,0.02141423100182715,1.6692975167686752,0.1461406296847382,0.8352290257165579,1071]
["Q9NWS8","Required for meiotic nuclear division protein 1 homolog [OS=Homo sapiens]",10,4,4,4,449,51.6,8.69,9.4,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","","RMND1","ENSG00000155906","","","",272.7,292.1,302.9,272,238.5,379.1,0.975382194244604,-0.035960458898120745,0.8743329563944292,0.0583231513605571,0.9179114591046944,0.037199208424853754,6962]
["Q9NWV4","UPF0587 protein C1orf123 [OS=Homo sapiens]",71,7,29,7,160,18,5.01,88.76,"","","other molecular function","CZIB","ENSG00000162384","","","",3885.6,3994.9,3882.2,4276.2,4756,2372.8,1.0313634370889961,0.04455280651036454,0.8779572257025873,0.05652664251514528,0.9198665944180348,0.03627515255568312,6976]
["Q9NWY4","Histone PARylation factor 1 [OS=Homo sapiens]",28,10,19,10,346,39.4,6.8,59.54,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","other molecular function","HPF1","ENSG00000056050","","","",2579.2,2639.4,2696.5,2934.3,2989.8,2963.4,0.8905879043600563,-0.16717007713109625,9.8201370759765636E-4,3.0078824500007557,0.0336973623888792,1.4724040915555205,213]
["Q9NX14-1","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [OS=Homo sapiens]",44,5,28,5,153,17.3,5.22,75.73,"cell organization and biogenesis","other membranes;mitochondrion","","NDUFB11","ENSG00000147123","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Nonalcoholic fatty liver disease",2831.1,2780.1,3023.8,2992.6,3305.4,3821.9,0.8532693010800503,-0.2289269512151004,0.12197769222044964,0.9137195876155148,0.34690075970399475,0.45979474906283635,2570]
["Q9NX20","39S ribosomal protein L16, mitochondrial [OS=Homo sapiens]",35,8,24,8,251,28.4,10.13,68.39,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL16","ENSG00000166902","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",4803.2,4979.9,5108.1,4468.8,4933,5423.2,1.0044654300168632,0.006427912700907643,0.9428769021567505,0.02554500313086138,0.966276959879934,0.014898375750205398,7132]
["Q9NX63","MICOS complex subunit MIC19 [OS=Homo sapiens]",52,16,78,16,227,26.1,8.28,211.32,"cell organization and biogenesis","other membranes;mitochondrion;nucleus","other molecular function","CHCHD3","ENSG00000106554","","Mitochondrial protein import; Cristae formation","",9908.2,8758.3,10124.2,11986.4,12012.6,9566.3,0.857751904496608,-0.22136767083452696,0.1570205574519978,0.8040434851480661,0.38877481518179263,0.41030187641509713,2952]
["Q9NX78","Transmembrane protein 260 [OS=Homo sapiens]",4,2,4,2,707,79.5,8.4,13.94,"","other membranes","","TMEM260","ENSG00000070269","","","",216.4,237.1,209.5,156,172.6,204.9,1.2427366447985004,0.3135205992881628,0.05982143852183067,1.2231431477309538,0.24183345915711305,0.6164836119863254,1808]
["Q9NXF7","DDB1- and CUL4-associated factor 16 [OS=Homo sapiens]",7,1,2,1,216,24.2,6.04,8.54,"protein metabolism;other metabolic processes","nucleus;other cell component","","DCAF16","ENSG00000163257","","Neddylation","",159.5,166.2,180.7,229.2,232.1,187.9,0.7800369685767098,-0.35838559511963014,0.03787509190892359,1.4216463046153172,0.19052239969877666,0.7200539570293658,1453]
["Q9NXR7-1","Isoform 1 of BRISC and BRCA1-A complex member 2 [OS=Homo sapiens]",11,4,10,4,415,46.9,6.14,26.99,"","","","BABAM2","","","","",992.8,1026.4,1030.8,1028.1,1062.9,648,1.1135450894487038,0.15515997663223263,0.48055376546211326,0.31825801541013776,0.633315447486943,0.19837991876800762,5546]
["Q9NXX6","Non-structural maintenance of chromosomes element 4 homolog A [OS=Homo sapiens]",12,4,6,4,385,44.3,5.38,9.92,"DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","","NSMCE4A","ENSG00000107672","","SUMOylation of DNA damage response and repair proteins","",185.8,187.1,210.7,222.1,226.9,149.5,0.9751044277360066,-0.036371363912973555,0.8594787348950153,0.06576486409851169,0.9079245661725202,0.04195023281803266,6919]
["Q9NY35-1","Claudin domain-containing protein 1 [OS=Homo sapiens]",14,3,7,3,253,28.6,5.82,21.12,"","plasma membrane;other membranes","","CLDND1","ENSCANG00000033095; ENSG00000080822; ENSGGOG00000007565; ENSPPYG00000013614","","","",502.3,495.4,517.9,418.4,460.1,392.7,1.1922592825676526,0.2536980151601893,0.01711980524960541,1.7665011800503838,0.13325735523894136,0.8753088104325217,939]
["Q9NYG2-1","Palmitoyltransferase ZDHHC3 [OS=Homo sapiens]",3,1,2,1,299,34.1,8.18,3.48,"protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","ZDHHC3","ENSCCAG00000029642; ENSG00000163812","","","",91.5,97.7,90.8,101,92.3,252.3,0.6283662477558348,-0.670322405507703,0.3482072807309437,0.4581621523794699,0.550518497698998,0.25922808393357866,4623]
["Q9NYH9","U3 small nucleolar RNA-associated protein 6 homolog [OS=Homo sapiens]",20,10,15,10,597,70.1,7.28,50.5,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","UTP6","ENSG00000108651","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",1110.1,1145.2,1123.3,2099.6,1986.2,1642.5,0.5898084946668296,-0.7616814940450942,0.004730672726456678,2.325077095918945,0.0724873940412408,1.1397375130750862,477]
["Q9NYP7-1","elongation of very long chain fatty acids protein 5 [OS=Homo sapiens]",3,1,11,1,299,35.3,9.42,23.14,"other metabolic processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","ELOVL5","ENSG00000012660; ENSGGOG00000011386; ENSPPAG00000035952; ENSPTRG00000018289","Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism","Synthesis of very long-chain fatty acyl-CoAs; alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Linoleic acid metabolism affected by coronavirus infection",2025,2087.2,2161.2,1949,2099,783.4,1.2984642132715156,0.3768062527169898,0.3139009745647134,0.5032073359488258,0.5323207014138028,0.27382664422558445,4310]
["Q9NYU2-1","UDP-glucose:glycoprotein glucosyltransferase 1 [OS=Homo sapiens]",46,53,322,53,1555,177.1,5.63,1048.08,"protein metabolism;other metabolic processes;stress response;other biological processes","ER/Golgi;other cell component","other molecular function","UGGT1","ENSG00000136731","Protein processing in endoplasmic reticulum","ER Quality Control Compartment (ERQC)","IL-18 signaling pathway",31751,31308.6,31084.3,28775.3,28188.4,27790.3,1.1107900512070228,0.15158616082668186,8.3390581058251931E-4,3.0788830000269325,0.03125650035665453,1.5050596495054775,195]
["Q9NZ09-1","Ubiquitin-associated protein 1 [OS=Homo sapiens]",25,9,16,9,502,55,5.11,48.67,"protein metabolism;other metabolic processes;transport","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","UBAP1","ENSG00000165006","","HCMV Late Events; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy","",1410,1218.3,1248.3,1845.5,1822.9,1944.1,0.6907082405345212,-0.5338516589786995,1.1818228118803892E-3,2.92744763139971,0.037556273617538105,1.4253175055333303,230]
["Q9NZB2-1","Constitutive coactivator of PPAR-gamma-like protein 1 [OS=Homo sapiens]",34,34,120,34,1118,121.8,8.88,407.71,"","plasma membrane;other membranes;cytosol;nucleus","","FAM120A","ENSG00000048828; ENSRROG00000028506","","","VEGFA-VEGFR2 signaling pathway",14400,13803.5,13653.2,14975.1,14645.7,20396.3,0.8368477980530656,-0.25696283885131954,0.22113356356312167,0.6553453353769831,0.4541346490820051,0.34281536149685604,3559]
["Q9NZJ4-1","Sacsin [OS=Homo sapiens]",1,4,4,4,4579,520.8,7.05,13.72,"other biological processes","mitochondrion;nucleus;other cell component","other molecular function","SACS","ENSG00000151835","","","",214.7,195.7,213,190.3,224.6,452.3,0.7188653136531364,-0.47620660172850376,0.38004895757269613,0.42016045434599464,0.5698005806971971,0.24427711249657733,4875]
["Q9NZJ7","Mitochondrial carrier homolog 1 [OS=Homo sapiens]",6,2,9,2,389,41.5,9.32,23.47,"cell organization and biogenesis;developmental processes;other biological processes","other membranes;mitochondrion","","MTCH1","ENSG00000137409","","","IL-18 signaling pathway",766.5,760.9,761,698.1,695.6,1375.5,0.8263758486205404,-0.27513000378280233,0.5177751337450136,0.28585881048021355,0.6608029426475125,0.17992803170956984,5727]
["Q9NZM4","BRD4-interacting chromatin-remodeling complex-associated protein [OS=Homo sapiens]",1,1,1,1,1560,158.4,6.65,2.78,"other biological processes","nucleus","other molecular function","BICRA","ENSG00000063169","","","",22.2,19.3,24.4,23.6,20.7,14.7,1.116949152542373,0.1595635107588482,0.4871300351567937,0.3123550921471424,0.6384137398172862,0.19489777475473047,5577]
["Q9NZN8-1","CCR4-NOT transcription complex subunit 2 [OS=Homo sapiens]",16,8,13,8,540,59.7,7.66,30.49,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","Cnot2; CNOT2; LOC111142051","ENSAMEG00000011938; ENSBIXG00000020780; ENSBIXG00005028198; ENSBMUG00000006457; ENSBTAG00000003748; ENSCAFG00000000441; ENSCANG00000037683; ENSCATG00000036994; ENSCCAG00000033920; ENSCSAG00000004177; ENSDLEG00000001866; ENSFCAG00000024278; ENSG00000111596; ENSGGOG00000027402; ENSLAFG00000004789; ENSLCNG00005003598; ENSMFAG00000034373; ENSMLEG00000041145; ENSMMUG00000014853; ENSMNEG00000045426; ENSMPUG00000017494; ENSPANG00000018112; ENSPCTG00005004059; ENSPPAG00000042482; ENSPTRG00000005216; ENSRBIG00000039989; ENSRFEG00010003667; ENSRROG00000042572; ENSSBOG00000026423; ENSSSUG00005015658; ENSUMAG00000020863","RNA degradation","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","",1350.7,1475.2,1491.4,1689.7,1572,1082.8,0.9937392104960295,-0.009060803551057412,0.9644253978106161,0.015731361148415966,0.9795699322676199,0.008964553937956775,7196]
["Q9P015","39S ribosomal protein L15, mitochondrial [OS=Homo sapiens]",40,10,20,10,296,33.4,10.01,72.38,"protein metabolism;other metabolic processes;other biological processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL15","ENSG00000137547","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",2245.8,2259.2,2276.1,2195.5,2298.5,2305.9,0.9972352534596098,-3.9942101602732875E-3,0.8726836771110537,0.05914314710752421,0.9164432465523982,0.03789442483411335,6960]
["Q9P0J1","[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial [OS=Homo sapiens]",7,3,6,3,537,61,6.67,16.84,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","other molecular function","PDP1","ENSG00000164951","","Regulation of pyruvate dehydrogenase (PDH) complex","Orexin receptor pathway",382.4,408.6,387.1,384.7,304.2,905.6,0.7388523047977422,-0.4366420937520701,0.5027161299066351,0.2986771799856458,0.64917883277166,0.18763564928994428,5660]
["Q9P0L0","vesicle-associated membrane protein-associated protein A [OS=Homo sapiens]",67,14,116,2,249,27.9,8.62,298.47,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","VAPA","ENSG00000101558","Cholesterol metabolism","Neutrophil degranulation; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; Sphingolipid de novo biosynthesis","Exercise-induced circadian regulation",18470.5,17267.9,17495.5,17705.1,19234.7,23910.2,0.8748381265406739,-0.19291199867540004,0.2529711887922907,0.5969289383539569,0.48275885610518343,0.3162697504386067,3830]
["Q9P0U4","CXXC-type zinc finger protein 1 [OS=Homo sapiens]",14,8,9,8,656,75.7,8.24,25.33,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","CXXC1","ENSG00000154832","","XBP1(S) activates chaperone genes","Male infertility",475.5,447.6,422,486.4,491.9,510.8,0.9032972936673158,-0.14672720849771667,0.04866730587732408,1.312762694746769,0.2186289727457663,0.6602922857996548,1627]
["Q9P1Y6-1","PHD and RING finger domain-containing protein 1 [OS=Homo sapiens]",7,11,18,10,1649,178.6,8.95,39.76,"RNA metabolism OR transcription;other metabolic processes","","other molecular function","KIAA1542; PHRF1","ENSG00000070047; ENSG00000274780","","","",1604.9,1541.7,1476.1,1434.1,1541.9,1609.4,1.0081345138919182,0.011688148339305515,0.8535278713341997,0.06878229274606726,0.9049079216103373,0.043395609934023145,6894]
["Q9P206","Uncharacterized protein KIAA1522 [OS=Homo sapiens]",2,1,2,1,1035,107,9.73,8.5,"other biological processes","","","KIAA1522","ENSG00000162522","","","",10.6,10.4,16.1,8.4,13,19.1,0.9160493827160494,-0.12650272115118374,0.7697557789533136,0.11364704194004303,0.8443861606438194,0.07345889332420648,6663]
["Q9P275","Ubiquitin carboxyl-terminal hydrolase 36 [OS=Homo sapiens]",3,4,6,4,1121,122.6,9.67,13.86,"","","","","","","","",273.2,266.1,258.3,529.1,609.7,529.3,0.4781487920388464,-1.0644684638496797,4.3584953531452918E-4,3.3606634127056036,0.022593079812864493,1.6460245634770108,141]
["Q9P287","BRCA2 and CDKN1A-interacting protein [OS=Homo sapiens]",37,10,30,10,314,36,4.61,75.8,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus","enzyme regulator activity;cytoskeletal activity","BCCIP","ENSG00000107949","","","",3170.5,3396.3,3452,3395.1,3431.7,2737.9,1.0474766589647349,0.06691809655373994,0.564470876920997,0.24835845997245729,0.6952675496150265,0.15784804006930733,5934]
["Q9P2E9-1","Ribosome-binding protein 1 [OS=Homo sapiens]",74,90,756,2,1410,152.4,8.6,2319.83,"","","","","","","","",89264.8,85198.9,84758.3,98845.2,102195.2,115150.4,0.8198277748751702,-0.2866072271446216,0.0213937780961995,1.6697125131637904,0.14613749916366556,0.835238328965027,1070]
["Q9P2K5-1","Myelin expression factor 2 [OS=Homo sapiens]",8,6,16,6,600,64.1,8.75,44.33,"stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","MYEF2","ENSG00000104177","","","Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Mitochondrial gene expression",2003.4,1874.1,1847.8,2748.8,2154.6,2391.6,0.784825222755312,-0.34955668717416055,0.04329764651304477,1.3635357095167544,0.2049627580076711,0.6883250436324989,1544]
["Q9P2M7-1","cingulin [OS=Homo sapiens]",18,23,34,23,1197,136.3,5.54,88.33,"","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity","CGN","ENSG00000143375","Tight junction","TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)","",2535,2421.2,2531.3,3284.1,3374.8,4248.9,0.686435394855058,-0.5428041500549599,0.021214367153519292,1.673369919157032,0.14531940911440722,0.8376763766975289,1067]
["Q9P2X0-1","Dolichol-phosphate mannosyltransferase subunit 3 [OS=Homo sapiens]",24,2,11,2,92,10.1,5.94,36.9,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi;other cell component","enzyme regulator activity","DPM3","ENSG00000179085","N-Glycan biosynthesis; Metabolic pathways","Synthesis of dolichyl-phosphate mannose; Defective DPM1 causes DPM1-CDG (CDG-1e); Defective DPM3 causes DPM3-CDG (CDG-1o); Defective DPM2 causes DPM2-CDG (CDG-1u)","",1100.1,1001.1,1212,984.5,1168.3,1177.9,0.9947458492208844,-7.6001208938982975E-3,0.9500944879292311,0.02223320150516584,0.9702725460772321,0.013106256835135114,7157]
["Q9UBC2-2","Isoform 2 of Epidermal growth factor receptor substrate 15-like 1 [OS=Homo sapiens]",37,29,73,2,910,99.5,5.08,234.54,"","","","EPS15L1","","","","",5958.6,5974.3,6078.2,6578.5,7071.1,6379.2,0.899260065505672,-0.15318969220994705,0.03235310293624454,1.4900840604832535,0.1784670410271784,0.748441976872107,1325]
["Q9UBD5-1","Origin recognition complex subunit 3 [OS=Homo sapiens]",22,13,21,12,711,82.2,7.61,48.09,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","ORC3","ENSG00000135336","Cell cycle","CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Assembly of the ORC complex at the origin of replication; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation","Cell cycle; G1 to S cell cycle control; DNA replication",1392.9,1386.2,1420.9,1364.7,1418.2,1248.2,1.0418992334598496,0.05921575514283739,0.33405335417491794,0.47618416320875406,0.5431804150532759,0.2650558973940287,4495]
["Q9UBM7","7-dehydrocholesterol reductase [OS=Homo sapiens]",23,11,81,11,475,54.5,8.7,186.98,"other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","DHCR7","ENSG00000172893","Steroid biosynthesis; Metabolic pathways","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis via desmosterol; Cholesterol biosynthesis via lathosterol","Vitamin D metabolism; Cholesterol biosynthesis pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias",10539.3,10238.1,10513,9074,9042.4,9645.7,1.1270905298950726,0.1726033999690868,5.7517692014292035E-3,2.2401985490084724,0.07872599455664053,1.103881844153056,534]
["Q9UBQ7","Glyoxylate reductase/hydroxypyruvate reductase [OS=Homo sapiens]",35,10,41,10,328,35.6,7.39,118.2,"other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle;other cell component","other molecular function","GRHPR","ENSG00000137106","Glycine, serine and threonine metabolism; Pyruvate metabolism; Glyoxylate and dicarboxylate metabolism; Metabolic pathways","Glyoxylate metabolism and glycine degradation","",4063.8,4139.2,4243.9,4041.3,3994,4479.8,0.9945505828958617,-0.007883346415363484,0.8959673927570151,0.04770779547557678,0.9336506520759942,0.029815595137087567,7014]
["Q9UBS0","Ribosomal protein S6 kinase beta-2 [OS=Homo sapiens]",20,4,6,4,482,53.4,7.34,21.13,"protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus;other cell component","kinase activity;other molecular function","RPS6KB2","ENSG00000175634","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; ErbB signaling pathway; HIF-1 signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; TGF-beta signaling pathway; Apelin signaling pathway; Fc gamma R-mediated phagocytosis; Thermogenesis; Insulin signaling pathway; Insulin resistance; Shigellosis; Human cytomegalovirus infection; Human papillomavirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Proteoglycans in cancer; Chemical carcinogenesis; Colorectal cancer; Pancreatic cancer; Acute myeloid leukemia; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer","Constitutive Signaling by AKT1 E17K in Cancer; AKT phosphorylates targets in the nucleus","IL-5 signaling pathway; AMP-activated protein kinase (AMPK) signaling; Follicle stimulating hormone (FSH) signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Thermogenesis; Translation inhibitors in chronically activated PDGFRA cells; Head and neck squamous cell carcinoma; Cytoplasmic ribosomal proteins; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; Malignant pleural mesothelioma; ErbB signaling pathway",281.3,292.1,272.4,267,302.6,319.1,0.9517272420389332,-0.07137992780418224,0.43230138444161037,0.3642133736396327,0.6004733597270486,0.22150625550534392,5262]
["Q9UBU6","Protein FAM8A1 [OS=Homo sapiens]",13,2,4,2,413,44.1,7.21,15.08,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","","FAM8A1","ENSG00000137414","","","",188.5,188.6,181.8,198.5,221.7,232.1,0.8568143492258167,-0.22294545352050657,0.03775535898986017,1.423021395967427,0.19057591081276795,0.7199319959445819,1448]
["Q9UBV2","Protein sel-1 homolog 1 [OS=Homo sapiens]",22,13,47,13,794,88.7,5.39,129.68,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;ER/Golgi","","SEL1L","ENSG00000071537","Protein processing in endoplasmic reticulum","ABC-family proteins mediated transport; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Defective CFTR causes cystic fibrosis; ER Quality Control Compartment (ERQC); Pre-NOTCH Processing in Golgi","Genotoxicity pathway; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5",2631.8,2775.3,2710.7,2729.8,2845.4,1926.2,1.08217132801877,0.11392892293170172,0.5204897690735191,0.2835878027117237,0.6626475739694044,0.17871738769537,5741]
["Q9UDW1","cytochrome b-c1 complex subunit 9 [OS=Homo sapiens]",38,2,6,2,63,7.3,9.47,16.43,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","UQCR10","ENSG00000184076","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly",876.4,796.7,922.9,809.2,859.4,551,1.1695801045233376,0.2259906752353693,0.28768422168573354,0.5410839567496822,0.5109803101582082,0.29159583441399783,4115]
["Q9UER7-1","Death domain-associated protein 6 [OS=Homo sapiens]",7,6,13,6,740,81.3,4.87,27.33,"cell organization and biogenesis;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","DAXX","ENSG00000204209; ENSG00000206206; ENSG00000206279; ENSG00000227046; ENSG00000231617","MAPK signaling pathway; Apoptosis; Parkinson disease; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Herpes simplex virus 1 infection","HCMV Early Events; Inhibition of DNA recombination at telomere; Regulation of TP53 Degradation; SUMOylation of transcription cofactors; Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations; Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations","Androgen receptor signaling pathway; Amyotrophic lateral sclerosis (ALS); Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; p38 MAPK signaling pathway",1784.1,1674.3,1662.9,2004.1,2021.9,1567.1,0.9156460639001625,-0.1271380517308997,0.36394144181513577,0.4389684887202056,0.5611915608073476,0.25088886851031766,4740]
["Q9UEW8","STE20/SPS1-related proline-alanine-rich protein kinase [OS=Homo sapiens]",22,11,31,9,545,59.4,6.29,89.07,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","STK39","ENSG00000198648","","","",2498.2,2545.4,2552.5,2496.9,2392,1922,1.115285791892408,0.15741344800577609,0.2145238607686413,0.6685243956758308,0.4499153223408893,0.34686921622588607,3485]
["Q9UFW8","CGG triplet repeat-binding protein 1 [OS=Homo sapiens]",25,3,3,3,167,18.8,8.95,11.39,"cell organization and biogenesis;other biological processes","nucleus","nucleic acid binding activity;other molecular function","CGGBP1","ENSG00000163320","","","",382,403.9,391,383.7,354.4,353.2,1.0784385595161734,0.10894398604286291,0.07332834410962213,1.1347281220707128,0.2683810050561984,0.5712482250574423,1997]
["Q9UG63","ATP-binding cassette sub-family F member 2 [OS=Homo sapiens]",38,26,112,26,623,71.2,7.37,269.11,"transport","","transporter activity;other molecular function","ABCF2","ENSG00000033050","Pathogenic Escherichia coli infection","","VEGFA-VEGFR2 signaling pathway",15100.6,15324.8,15939,17046.7,16816.5,13743.9,0.9738967506947495,-0.03815926421871683,0.7241318400049159,0.14018235621446573,0.8122589961012784,0.09030546996696459,6516]
["Q9UGP4","LIM domain-containing protein 1 [OS=Homo sapiens]",34,15,32,15,676,72.1,6.65,121.56,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","LIMD1","ENSG00000144791","Hippo signaling pathway; Hippo signaling pathway","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Malignant pleural mesothelioma",3190.2,3049.3,3000.9,3581.3,3726.7,2844.1,0.910195920055949,-0.13575097543276682,0.33734554542125655,0.4719250202403908,0.5446561942752296,0.2638775528516701,4527]
["Q9UGU5","HMG domain-containing protein 4 [OS=Homo sapiens]",7,3,3,3,601,65.7,9.32,9.13,"cell-cell signaling;transport;signal transduction;other biological processes","nucleus","nucleic acid binding activity;other molecular function","HMGXB4","ENSG00000100281","","","",140.5,129,133.9,167.2,147.2,135.5,0.8966436985996888,-0.15739328296608457,0.19020303741158104,0.7207825519592986,0.4243571429918333,0.3722684831637065,3276]
["Q9UH17-1","DNA dC->dU-editing enzyme APOBEC-3B [OS=Homo sapiens]",21,6,14,4,382,45.9,6.06,42.85,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","other molecular function","APOBEC3B","ENSG00000179750","Human immunodeficiency virus 1 infection","Formation of the Editosome","",439.9,487.3,473.5,781.6,688.1,558.5,{"$f":"AVERAGE(S6722:U6722)/AVERAGE(V6722:X6722)","v":0.6906123656444138},{"$f":"LOG(Y6722,2)","v":-0.5340519285296019},{"$f":"TTEST(V6722:X6722,S6722:U6722,2,2)","v":0.034192842715660324},1.4660647914407976,{"$f":"AA6722*7309/AE6722","v":0.18255331439646552},0.7386102776908147,1369]
["Q9UHB7-1","AF4/FMR2 family member 4 [OS=Homo sapiens]",10,9,12,9,1163,127.4,9.31,24.62,"other biological processes","nucleus;other cell component","","AFF4","ENSG00000072364","","RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex","",632.8,585.3,574.6,510.8,527.4,689.4,1.0376823338735817,0.053364858448050285,0.7346821525776142,0.13390051021851235,0.819315204941987,0.08654898538089634,6554]
["Q9UHG3","prenylcysteine oxidase 1 [OS=Homo sapiens]",29,12,37,12,505,56.6,6.18,118.54,"protein metabolism;other metabolic processes;transport","non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle","other molecular function","PCYOX1","ENSG00000116005","Terpenoid backbone biosynthesis","","",4173,4420.6,4252.7,3712.2,3092.6,3968.9,1.1923758782962213,0.25383909508913577,0.06280740270434455,1.2019891657504216,0.24787219566201638,0.6057721862123642,1852]
["Q9UHJ6","Sedoheptulokinase [OS=Homo sapiens]",18,5,12,5,478,51.5,6.83,47.44,"other metabolic processes;other biological processes","cytosol;other cell component","kinase activity;other molecular function","SHPK","ENSG00000197417","Metabolic pathways","Pentose phosphate pathway","",741.7,796.1,767,811.1,678.7,3818.4,0.4341961493538299,-1.203581163344179,0.3841538023148446,0.41549486385247864,0.5716164782408792,0.24289526010161697,4912]
["Q9UHQ4","B-cell receptor-associated protein 29 [OS=Homo sapiens]",37,12,28,12,241,28.3,9.54,66.24,"transport;other biological processes","other membranes;ER/Golgi","","BCAP29","ENSG00000075790; ENSG00000283852","","","",4330.7,4243.2,4352.9,4050.9,4329.4,3711.1,1.0690904279074382,0.09638388708651956,0.20052850434785888,0.6978238853824008,0.4362091780590775,0.3603052008882719,3360]
["Q9UHW5-1","GPN-loop GTPase 3 [OS=Homo sapiens]",12,2,2,2,284,32.7,4.5,4.46,"","other cell component","other molecular function","GPN3","ENSG00000111231; ENSNLEG00000029104; ENSPPAG00000031515","","","",70.9,75.9,75.4,77.3,75.2,122.8,0.8071195059934618,-0.3091457932064689,0.3201812097437856,0.4946041588128395,0.535393379550979,0.27132700341851906,4371]
["Q9UI09","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [OS=Homo sapiens]",6,1,3,1,145,17.1,9.63,7.87,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;mitochondrion","transporter activity","NDUFA12","ENSG00000184752","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease",459,402.1,476.3,572.7,488.5,5215.5,0.2130737489445091,-2.2305752333502444,0.35131183460535226,0.45430721992835965,0.5524393715857401,0.25771537742666095,4648]
["Q9UI32","Glutaminase liver isoform, mitochondrial [OS=Homo sapiens]",1,1,2,1,602,66.3,7.3,4.69,"other metabolic processes;other biological processes","mitochondrion","other molecular function","GLS2","ENSG00000135423","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; D-Amino acid metabolism; Metabolic pathways; Glutamatergic synapse; GABAergic synapse; Proximal tubule bicarbonate reclamation; MicroRNAs in cancer; Central carbon metabolism in cancer","TP53 Regulates Metabolic Genes; Glutamate and glutamine metabolism; Glutamate Neurotransmitter Release Cycle","p53 transcriptional gene network; Neuroinflammation and glutamatergic signaling",338,321.5,330.3,256.7,211.8,134,1.6428215767634855,0.7161758008623167,0.023366370303385255,1.6314087450163697,0.15113699163490518,0.8206292266158163,1130]
["Q9UIA9","exportin-7 [OS=Homo sapiens]",31,26,75,26,1087,123.8,6.32,238.09,"transport","nucleus;other cell component","other molecular function","XPO7","ENSG00000130227","Nucleocytoplasmic transport","","",6022,6413.8,6524.8,5700,6001.3,7021.5,1.012701091717051,0.018208411915409773,0.8620669152584113,0.06445902211081854,0.9094756183059655,0.04120893923613576,6928]
["Q9UII2-1","ATPase inhibitor, mitochondrial [OS=Homo sapiens]",24,4,10,4,106,12.2,9.35,31.07,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","mitochondrion;other cell component","enzyme regulator activity;other molecular function","ATP5IF1","ENSG00000130770; ENSG00000285390; ENSPPAG00000043083; ENSPPYG00000001644; ENSPTRG00000000428","","","Electron transport chain: OXPHOS system in mitochondria",945.6,1203.2,987.3,680.2,661.7,675.3,1.5546797541146145,0.6366174326179265,0.00958343815626779,2.018478655387261,0.10346432715533424,0.9852093621884324,677]
["Q9UJ04","testis-specific Y-encoded-like protein 4 [OS=Homo sapiens]",2,1,2,1,414,45.1,8.57,4.23,"cell organization and biogenesis","nucleus;other cell component","other molecular function","TSPYL4","ENSG00000187189","","","",299.5,324.6,304,228.9,231,79.7,1.71997776130467,0.7823899115187206,0.06295237127242354,{"$f":"-LOG10(AA6787)","v":1.2009879063641773},0.24764202455874254,{"$f":"-LOG10(AC6787)","v":0.6061756541378274},1858]
["Q9UJ70","N-acetyl-D-glucosamine kinase [OS=Homo sapiens]",53,12,63,12,344,37.4,6.24,220.03,"other metabolic processes","cytosol","kinase activity;other molecular function","NAGK","ENSG00000124357","Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars","Synthesis of UDP-N-acetyl-glucosamine","",5971,6031.7,6019.7,6324.2,6202.2,5875.8,0.979361163339166,-0.03008710791654816,0.4018649570588403,0.39591986297817794,0.5830152781149391,0.23432006425629923,5038]
["Q9UJF2","ras GTPase-activating protein nGAP [OS=Homo sapiens]",6,6,7,5,1139,128.5,8.24,17.53,"signal transduction;other biological processes","cytosol","enzyme regulator activity","RASAL2","ENSG00000075391","Ras signaling pathway","Regulation of RAS by GAPs; RND1 GTPase cycle; RND3 GTPase cycle","Ras signaling",228.6,199.4,218.3,258.2,279.6,347.2,0.7302824858757061,-0.45347346357978346,0.04751733554232058,1.3231479197042566,0.2161196051517244,0.6653058345836281,1607]
["Q9UJQ1-1","Lysosome-associated membrane glycoprotein 5 [OS=Homo sapiens]",9,2,5,2,280,31.5,6.46,17.09,"other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","","LAMP5","ENSG00000125869","","","",407.4,429.8,393.5,462.5,462.6,243.1,1.0535011128231466,0.075191838088382,0.7920230329542037,0.1012621884364402,0.8609304503067037,0.06503193131990058,6724]
["Q9UJX4","Anaphase-promoting complex subunit 5 [OS=Homo sapiens]",17,8,16,8,755,85,6.87,43.29,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","ANAPC5","ENSG00000089053","Cell cycle; Oocyte meiosis; Ubiquitin mediated proteolysis; IL-17 signaling pathway; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection","Separation of Sister Chromatids; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Inactivation of APC/C via direct inhibition of the APC/C complex; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Cell cycle",658.8,649.8,667.1,610.4,655.3,485.9,1.1279401689883535,0.17369054274282533,0.216232733200589,0.6650785621295049,0.4514267486327063,0.3454127110105646,3501]
["Q9UK23","N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [OS=Homo sapiens]",6,3,4,3,515,56,6.6,12.23,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport","other membranes;ER/Golgi","other molecular function","NAGPA","ENSG00000103174","Lysosome","","",351,340,357.3,318.8,369.4,440.7,0.9286030649304633,-0.10686605224179825,0.4937764361123592,0.306469639212825,0.6437766627800987,0.19126477075311937,5606]
["Q9UK45","U6 snRNA-associated Sm-like protein LSm7 [OS=Homo sapiens]",54,5,11,5,103,11.6,5.27,20.11,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","LSM7","ENSG00000130332","RNA degradation; Spliceosome","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease","mRNA processing",1032.5,1120.1,1147.2,1203.1,1268.4,913.7,0.9747725392886685,-0.03686248599895586,0.8156745245335646,0.08848310153649361,0.8784094739672643,0.05630298884398741,6787]
["Q9UK97","F-box only protein 9 [OS=Homo sapiens]",9,3,3,3,447,52.3,6.15,9.57,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;other cell component","other molecular function","FBXO9","ENSG00000112146","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",267.5,265.9,231.7,282.5,265.3,548.2,0.6980839416058394,-0.5185275701183804,0.2981317655578403,0.5255917479811014,0.5195624879499893,0.2843622122264535,4194]
["Q9UKG9-1","peroxisomal carnitine O-octanoyltransferase [OS=Homo sapiens]",8,3,3,3,612,70.1,7.08,9.46,"other metabolic processes;transport","cytosol;other cytoplasmic organelle;other cell component","other molecular function","CROT","ENSG00000005469","Peroxisome","Peroxisomal protein import; Beta-oxidation of pristanoyl-CoA","",113.8,131.6,115.2,123.8,123.7,96.6,1.0479511769834349,0.0675715046953602,0.6344276568363564,0.19761789291994802,0.7452638611084745,0.12768993780865967,6222]
["Q9UKK3","Poly [ADP-ribose] polymerase 4 [OS=Homo sapiens]",19,24,55,24,1724,192.5,5.66,167.84,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","PARP4","ENSG00000102699","Base excision repair; Apoptosis","Maturation of nucleoprotein; Nicotinamide salvaging; Maturation of nucleoprotein","NAD+ biosynthetic pathways; 16p11.2 proximal deletion syndrome",3846.6,3903.8,3892.5,4340.3,4259.5,5710.1,0.8136255319743675,-0.2975631424927728,0.13211705777312538,0.8790411065452932,0.3577782790899494,0.4463860292178369,2699]
["Q9UKM9-1","RNA-binding protein Raly [OS=Homo sapiens]",74,19,91,1,306,32.4,9.17,296.76,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","RALY","ENSG00000125970","","","",12237.6,13085,13362,17710.5,16283.3,9766.3,0.8840153473141056,-0.1778566785492169,0.5307575739306296,0.27510379971908216,0.6706962496298361,0.1734741221215836,5784]
["Q9UKQ2-1","Disintegrin and metalloproteinase domain-containing protein 28 [OS=Homo sapiens]",9,8,14,8,775,87.1,6.95,29.09,"protein metabolism;other biological processes","non-structural extracellular;plasma membrane;other membranes;mitochondrion","other molecular function","ADAM28","ENSG00000042980","","","",1406.9,1440.8,1479.2,1444.9,1472.7,1416.4,0.99836179049377,-2.3653747497115905E-3,0.9330383730141045,0.03010049468267392,0.9598279336185912,0.01780661506218948,7105]
["Q9UKV5","E3 ubiquitin-protein ligase AMFR [OS=Homo sapiens]",20,6,8,6,643,72.9,6.39,27.33,"cell-cell signaling;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","AMFR","ENSG00000159461","Protein processing in endoplasmic reticulum","ER Quality Control Compartment (ERQC); N-glycan trimming in the ER and Calnexin/Calreticulin cycle","Sterol regulatory element-binding proteins (SREBP) signaling",446.9,436.2,408,377.8,432.2,465,1.012627450980392,0.018103499429961437,0.8570900059526633,0.06697356893319761,0.9065804418969633,0.04259365442342302,6910]
["Q9UL15-1","BAG family molecular chaperone regulator 5 [OS=Homo sapiens]",25,8,17,8,447,51.2,6.05,44.99,"cell organization and biogenesis;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","BAG5","ENSG00000166170","","Regulation of HSF1-mediated heat shock response","",922.6,975.5,947.6,932.6,886.5,876.3,1.055761668027009,0.07828419154999702,0.09588437896277408,1.018252140304397,0.307511595365913,0.5121385036007995,2279]
["Q9UL26","Ras-related protein Rab-22A [OS=Homo sapiens]",26,4,7,4,194,21.8,8.15,16.74,"cell organization and biogenesis;transport","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","RAB22A","ENSG00000124209","Endocytosis","RAB geranylgeranylation","",916.3,1151.7,1183,716.9,816.9,261.7,1.8106377053745477,0.8564979030256978,0.06348756042832443,1.1973113607957482,0.2486766233497445,0.6043650383222564,1866]
["Q9ULC3","Ras-related protein Rab-23 [OS=Homo sapiens]",27,6,13,6,237,26.6,6.6,31.71,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","RAB23","ENSG00000112210","","RAB geranylgeranylation","Genes related to primary cilium development (based on CRISPR); Ciliopathies",1327.6,1525.1,1589.4,1206.6,1309.9,1080.4,1.2349801217715255,0.30448782039097094,0.05215310710107171,1.2827198127091057,0.22595557783149564,0.645976933414258,1687]
["Q9ULH1-1","Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 [OS=Homo sapiens]",14,14,26,14,1129,125.4,7.31,81.99,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","ASAP1","ENSG00000153317","Endocytosis; Fc gamma R-mediated phagocytosis","VxPx cargo-targeting to cilium","EGF/EGFR signaling pathway; CCL18 signaling pathway",1921.9,1939.5,1943.9,1860.9,1884.6,1952.6,1.018813288640073,0.026889682284721488,0.27518675521456337,0.5603724726009616,0.501956574460505,0.29933385314968836,4007]
["Q9ULJ3","Zinc finger and BTB domain-containing protein 21 [OS=Homo sapiens]",2,3,4,3,1066,118.8,8.29,9.48,"other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","ZBTB21","ENSG00000173276","","","",447.2,453.9,471.7,592.5,636.5,524.7,0.782802075611564,-0.3532805135898143,0.018947206812270606,1.722454804452014,0.13876265991070727,0.8577273838554123,998]
["Q9ULN7-5","Isoform 2 of Paraneoplastic antigen-like protein 8B [OS=Homo sapiens]",2,1,1,1,635,68.6,5.45,0,"","","","PNMA8B","ENSG00000204851","","","",33.4,21.1,31.1,38.5,34.3,36.4,0.7838827838827839,-0.35129015451870554,0.11828303663087877,0.9270775345423886,0.34225285618966467,0.46565291887772764,2526]
["Q9ULQ1-1","Two pore calcium channel protein 1 [OS=Homo sapiens]",3,2,2,2,816,94.1,8.27,6.27,"transport;signal transduction;other biological processes","other membranes;other cytoplasmic organelle","transporter activity;other molecular function","TPCN1","ENSG00000186815; ENSGGOG00000010443","Calcium signaling pathway","Stimuli-sensing channels","",111.2,108.9,116.3,95.7,92.7,85.3,1.2290829375228354,0.29758227089018807,0.005256562944556574,2.279298130772716,0.0750394893784453,1.1247101298645736,512]
["Q9ULU8-3","Isoform 3 of Calcium-dependent secretion activator 1 [OS=Homo sapiens]",4,3,5,1,1314,148.7,5.81,6.79,"","","","CADPS","","","","",34.5,47.5,37.3,40.1,37.4,55.4,0.8976674191121142,-0.1557470615809467,0.5446539451916591,0.26387934621528364,0.6796782799053844,0.1676966083592707,5857]
["Q9ULZ3","apoptosis-associated speck-like protein containing a CARD [OS=Homo sapiens]",47,9,36,9,195,21.6,6.34,109.68,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function","PYCARD","ENSG00000103490","Necroptosis; NOD-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Legionellosis; Yersinia infection; Influenza A; Lipid and atherosclerosis","Neutrophil degranulation; The AIM2 inflammasome; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; CLEC7A/inflammasome pathway","Nucleotide-binding oligomerization domain (NOD) pathway; Nanomaterial-induced inflammasome activation; TYROBP causal network in microglia; Acute viral myocarditis; Cytosolic DNA-sensing pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Prostaglandin signaling",3606.4,3248.1,3594.4,3538.5,3974.9,3412.1,0.9563772825042332,-0.06434823377104808,0.4856839668571087,0.3136462329906558,0.6372041130422917,0.19572142956612568,5571]
["Q9UM13","Anaphase-promoting complex subunit 10 [OS=Homo sapiens]",11,2,3,2,185,21.2,9.06,7.44,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","","ANAPC10","ENSG00000164162","Cell cycle; Oocyte meiosis; Ubiquitin mediated proteolysis; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection","Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; Senescence-Associated Secretory Phenotype (SASP); APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Cell cycle",247.2,262.9,247,285.7,268.4,187.7,1.0206255055270963,0.029453600369950518,0.8759385652299543,0.057526352413251186,0.9185416030510382,0.03690116862728764,6970]
["Q9UMS4","Pre-mRNA-processing factor 19 [OS=Homo sapiens]",51,15,72,15,504,55.1,6.61,239.65,"cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","PRPF19","ENSG00000110107","Spliceosome; Ubiquitin mediated proteolysis","mRNA Splicing - Major Pathway; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of TC-NER Pre-Incision Complex","",8696.8,8702.5,8635.5,9516.5,9443,6134,1.0375117062187418,0.053127614443610305,0.792475730756264,0.10101402899667705,0.8609103918099782,0.06504204990255986,6728]
["Q9UNA1-1","Rho GTPase-activating protein 26 [OS=Homo sapiens]",6,4,5,4,814,92.2,6.64,11.44,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","ARHGAP26","ENSG00000145819","","RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOB GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOD GTPase cycle; RHOQ GTPase cycle","",501,530.4,569.9,482.9,418.3,989.1,0.8471142146749194,-0.239371596597498,0.6238077781822464,0.20494921438078478,0.7377687784359287,0.13207972758562764,6180]
["Q9UNF1","Melanoma-associated antigen D2 [OS=Homo sapiens]",41,19,58,18,606,64.9,9.32,192.7,"transport;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","","MAGED2","ENSG00000102316","","Platelet degranulation","",6480.4,6483.1,6579.1,8736.3,8331.5,8860,0.7537315159789878,-0.40787737715480843,1.9791069226636536E-4,3.7035307420905084,0.016072547219720717,1.7939152896458603,90]
["Q9UNM6","26S proteasome non-ATPase regulatory subunit 13 [OS=Homo sapiens]",61,21,115,21,376,42.9,5.81,329.62,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","PSMD13","ENSG00000185627","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection","Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease",17000.8,18071.4,18598.5,16496.8,15674.4,9014.6,1.3031360323218197,0.3819876924344084,0.15995591629920425,0.7959996920063853,0.3914020061034094,0.4073769527265406,2987]
["Q9UNS1","Protein timeless homolog [OS=Homo sapiens]",7,6,12,6,1208,138.6,5.4,27.19,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity","TIMELESS","ENSG00000111602","","Processing of DNA double-strand break ends","",371.4,336.2,377,524.2,513.7,737.1,0.6110422535211267,-0.7106559491515604,0.035716902245840024,1.447126214841648,0.18527667744133763,0.7321792460670314,1409]
["Q9UNZ2","NSFL1 cofactor p47 [OS=Homo sapiens]",61,22,122,1,370,40.5,5.1,384.24,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","NSFL1C","ENSG00000088833","Protein processing in endoplasmic reticulum","RHOH GTPase cycle","",13629.4,14042.7,14048,14706.7,15005.6,17377.1,0.8859764617939493,-0.1746597244414174,0.10474156692592174,0.9798809333733226,0.32031636513036066,0.49442087243748734,2390]
["Q9UPN9-2","Isoform Beta of E3 ubiquitin-protein ligase TRIM33 [OS=Homo sapiens]",7,7,8,1,1110,120.5,6.67,20.82,"","","","TRIM33","","","","",78.6,66.2,64.9,81.2,86.9,63.8,0.9042690815006468,-0.14517595854941107,0.4181485547380405,0.37866939994430804,0.5931006766117481,0.22687158052140982,5153]
["Q9UPQ3-1","Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 [OS=Homo sapiens]",4,3,8,2,857,94.4,7.94,10.84,"transport","nucleus;other cell component","enzyme regulator activity;other molecular function","AGAP1","ENSG00000157985","Endocytosis","","",197.8,195.5,229.3,184.4,181.9,233.8,1.037493751041493,0.05310264694765975,0.7281221778071211,0.137795740610858,0.8147343841996705,0.08898395479151562,6532]
["Q9UPT6","C-Jun-amino-terminal kinase-interacting protein 3 [OS=Homo sapiens]",4,7,12,4,1336,147.4,5.4,32.57,"cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","MAPK8IP3","ENSG00000138834","MAPK signaling pathway","","MAPK signaling pathway",743.4,847.2,853.1,244,246.7,379.3,2.8088505747126433,1.4899798779869045,7.8106068248584473E-4,3.1073152234274777,0.03052819533844406,1.5152988680800035,187]
["Q9UPY8","Microtubule-associated protein RP/EB family member 3 [OS=Homo sapiens]",19,5,11,1,281,32,5.54,26.85,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MAPRE3","ENSG00000084764","","","",18.4,23.6,25.1,22.4,24.6,13,1.1183333333333332,0.16135026570430247,0.5943371014623773,0.22596715808531198,0.7163604674453357,0.14486838882533618,6064]
["Q9UPY8-2","Isoform 2 of Microtubule-associated protein RP/EB family member 3 [OS=Homo sapiens]",19,5,11,1,266,30.4,5.3,28.17,"","","","MAPRE3","","","","",193.4,186.3,194.4,194.9,218.3,448.5,0.666241151212719,-0.5858836282707913,0.30189919322717024,0.520138047551451,0.5228865410657315,0.281592536629152,4220]
["Q9UQ90","Paraplegin [OS=Homo sapiens]",11,7,10,7,795,88.2,8.69,29.27,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes","other membranes;mitochondrion;other cell component","other molecular function","SPG7","ENSG00000197912","","Processing of SMDT1","",752,803.9,786.9,704.2,703.1,870,1.0287621305932464,0.04090944220805739,0.7235355216723052,0.14054014251650399,0.8119639379553014,0.09046325880661353,6513]
["Q9UQL6-1","histone deacetylase 5 [OS=Homo sapiens]",5,4,6,4,1122,121.9,6.24,18.79,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","HDAC5","ENSG00000108840","Apelin signaling pathway; Neutrophil extracellular trap formation; Alcoholism; Viral carcinogenesis; MicroRNAs in cancer","Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Regulation of PTEN gene transcription","MicroRNAs in cardiomyocyte hypertrophy; Cell differentiation - expanded index; Cell differentiation - index; Neural crest differentiation; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; VEGFA-VEGFR2 signaling pathway; Ethanol effects on histone modifications; Rett syndrome causing genes",286.1,272.3,241.8,279.3,268.1,372,0.8703502284098324,-0.20033203747120207,0.3248832922320285,0.48827262253624587,0.5379637478305157,0.26924698947790915,4414]
["Q9Y222-1","Cyclin-D-binding Myb-like transcription factor 1 [OS=Homo sapiens]",3,2,2,2,760,84.4,4.61,4.62,"cell cycle OR cell proliferation;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","DMTF1","ENSG00000135164","","","",106.1,96,90.4,97.5,83.5,79.9,1.1211192027596781,0.16493968054067726,0.21026982467515712,0.6772230474152293,0.4466324174805938,0.3500497581521865,3441]
["Q9Y248","Dna replication complex gins protein psf2 [OS=Homo sapiens]",16,3,4,3,185,21.4,5.44,9.5,"DNA metabolism;other metabolic processes;stress response","nucleus","","GINS2","ENSG00000131153","","Unwinding of DNA","",321.6,321.9,351.3,346.6,381.8,455,0.8406286969748181,-0.2504593875331077,0.13304030228108985,0.8760167770262088,0.3589485305915414,0.4449678201754041,2709]
["Q9Y259-1","Choline/ethanolamine kinase [OS=Homo sapiens]",8,3,3,3,395,45.2,5.49,5.95,"other metabolic processes","cytosol","kinase activity;other molecular function","CHKB","ENSG00000100288","Glycerophospholipid metabolism; Metabolic pathways; Choline metabolism in cancer","Synthesis of PC; Synthesis of PE","Fatty acid beta-oxidation; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids",194.5,179,191,180.1,175.5,597.2,0.5924643157010915,-0.7551998322037509,0.40718798078323887,0.3902050498180427,0.5863153962854004,0.23186870135673698,5076]
["Q9Y281-1","Cofilin-2 [OS=Homo sapiens]",33,5,42,1,166,18.7,7.88,107.36,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity","CFL2; CFL2b; LOC101358143; LOC111160529","ENSAMEG00000015508; ENSANAG00000001737; ENSBIXG00000015466; ENSBIXG00005004635; ENSBTAG00000015053; ENSCAFG00000032562; ENSCANG00000033619; ENSCCAG00000037328; ENSCHIG00000015758; ENSCJAG00000041665; ENSCPOG00000033162; ENSECAG00000000511; ENSFCAG00000008480; ENSG00000165410; ENSGGOG00000038032; ENSHGLG00000001467; ENSLCNG00005006126; ENSMFAG00000001352; ENSMLEG00000005793; ENSMMNG00015019505; ENSMMUG00000039560; ENSMNEG00000039241; ENSMPUG00000016306; ENSNLEG00000003417; ENSPANG00000021779; ENSPCOG00000013026; ENSPCTG00005008413; ENSPPAG00000007558; ENSPPYG00000005737; ENSPTRG00000006254; ENSRROG00000036826; ENSSBOG00000014011; ENSSSCG00000001959; ENSSSCG00015060726; ENSSSCG00025071059; ENSSSCG00030060165; ENSSSCG00035044355; ENSSSCG00040010975; ENSSSCG00045008975; ENSSSCG00050005802; ENSSSCG00055017925; ENSSSCG00060075576; ENSSSCG00065063654; ENSSSCG00070007061; ENSSSUG00005010833; ENSVVUG00000019333","Axon guidance; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Pertussis; Human immunodeficiency virus 1 infection","","Actin cytoskeleton regulation; G13 signaling pathway; G13 signaling pathway; Leptin signaling pathway; Microtubule cytoskeleton regulation; Microtubule cytoskeleton regulation; Leptin signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; G13 signaling pathway",55.9,64.6,64,63.6,55.9,53,1.0695652173913044,0.09702445439486472,0.3976495529714869,0.4004995014348532,0.5797766971212045,0.23673924416393394,5013]
["Q9Y2C4","Nuclease EXOG, mitochondrial [OS=Homo sapiens]",7,3,6,3,368,41.1,8.27,11.83,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes","other membranes;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","EXOG","ENSG00000157036","","","",760.1,771.5,776.2,743.2,738,671.8,1.0718996748722713,0.10016988215996889,0.09284333067115842,1.032249288011908,0.30186472592326374,0.5201876330249586,2248]
["Q9Y2D4","Exocyst complex component 6B [OS=Homo sapiens]",9,7,9,6,811,94.1,6.46,28.88,"cell organization and biogenesis;transport","other membranes;other cell component","","EXOC6B","ENSG00000144036","","","Ciliary landscape",595.1,639.2,609,602.3,531.1,718.3,0.9954636280174975,-6.559490782274028E-3,0.9625762137103593,0.016564874408058497,0.9786436981512054,0.009375396135620566,7189]
["Q9Y2H0-1","Isoform 2 of Disks large-associated protein 4 [OS=Homo sapiens]",3,2,2,2,989,107.5,7.3,6.2,"","","","DLGAP4","","","","",158.2,147.6,134.3,168.6,167.9,195.8,0.8267894044711629,-0.27440819453093984,0.055620824813097644,1.2547625751784235,0.23323729693570322,0.6322020004044437,1743]
["Q9Y2H6","Fibronectin type-III domain-containing protein 3a [OS=Homo sapiens]",11,9,18,9,1198,131.8,6.71,49.03,"cell adhesion;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","","FNDC3A","ENSG00000102531","","","",1412.5,1406.8,1412,1463.7,1450.1,825.3,{"$f":"AVERAGE(S7042:U7042)/AVERAGE(V7042:X7042)","v":1.1316359551763793},{"$f":"LOG(Y7042,2)","v":0.17840992095124353},{"$f":"TTEST(V7042:X7042,S7042:U7042,2,2)","v":0.47942670629034995},0.3192777774123297,{"$f":"AA7042*7309/AE7042","v":0.632514403659958},0.1989295802567865,5540]
["Q9Y2K7","Lysine-specific demethylase 2A [OS=Homo sapiens]",18,21,32,21,1162,132.7,7.58,78.47,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus","nucleic acid binding activity;other molecular function","KDM2A","ENSG00000173120","","HDMs demethylate histones","",3065.9,3060.1,3021.3,3333.4,3320.5,2496.9,0.9996175197796915,-0.000551907870728757,0.9968418778068546,1.3737253815376221E-3,0.9988918679586374,4.815224753271243E-4,7294]
["Q9Y2R0","Cytochrome c oxidase assembly factor 3 homolog, mitochondrial [OS=Homo sapiens]",27,3,7,3,106,11.7,9.6,19.06,"cell organization and biogenesis;other biological processes","other membranes;mitochondrion","","COA3","ENSG00000183978","Thermogenesis","","Mitochondrial complex IV assembly",449.9,366.9,517.1,604.4,982.6,283.6,0.7130867101464772,-0.48785057825710615,0.43543786311240684,0.36107380996226524,0.6033394012300629,0.21943831204802255,5275]
["Q9Y2R9","28S ribosomal protein S7, mitochondrial [OS=Homo sapiens]",15,3,10,3,242,28.1,9.99,35.8,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPS7","ENSG00000125445","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1144.9,955,1163.9,1572,1982.6,1426.1,0.6552894171501998,-0.6097958623325289,0.033241271711674875,1.4783223697616266,0.18063974345028375,0.7431866922160805,1345]
["Q9Y2S0-1","DNA-directed RNA polymerases I and III subunit RPAC2 [OS=Homo sapiens]",24,3,7,3,133,15.2,5.8,19.33,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","POLR1D","ENSG00000186184; ENSGGOG00000004235; ENSNLEG00000000358; ENSPTRG00000005734","RNA polymerase; Cytosolic DNA-sensing pathway","","Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway",474.2,492.4,490.3,604.5,638.3,889.7,0.6831887456037513,-0.549643885730176,0.0669002672056938,1.1745721476174296,0.2553389310738464,0.5928829640380981,1915]
["Q9Y2S7","Polymerase delta-interacting protein 2 [OS=Homo sapiens]",41,12,33,12,368,42,8.63,108.07,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component","nucleic acid binding activity","POLDIP2","ENSG00000004142","","","",3115.4,3073.1,3110.1,3231,2999.9,5148.5,0.8171432588712938,-0.2913390657881411,0.366086942532538,0.43641576111354413,0.5624825442443389,0.24989095064947295,4757]
["Q9Y2T2","ap-3 complex subunit mu-1 [OS=Homo sapiens]",30,8,16,7,418,46.9,6.93,58.53,"transport","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","AP3M1","ENSG00000185009","Lysosome","Association of TriC/CCT with target proteins during biosynthesis","",1407.5,1563,1540.7,1369.3,1354.9,1120.2,1.1734470918738946,0.23075279540866667,0.07772656588841718,1.1094305198496008,0.2764493771671247,0.5583843841777159,2055]
["Q9Y2U5","Mitogen-activated protein kinase kinase kinase 2 [OS=Homo sapiens]",8,4,5,2,619,69.7,8,15.49,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus","kinase activity;other molecular function","MAP3K2","ENSG00000169967","MAPK signaling pathway; Gap junction; GnRH signaling pathway","","IL-1 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; MAPK cascade; EGF/EGFR signaling pathway; Insulin signaling; Malignant pleural mesothelioma",162.1,202.8,200.9,230.2,191.5,185.3,0.9321252059308072,-0.10140433974679182,0.5164078312735152,0.28700718032295797,0.6598644823038676,0.18054524723200918,5720]
["Q9Y2U8","inner nuclear membrane protein Man1 [OS=Homo sapiens]",29,20,56,20,911,99.9,7.55,184,"cell organization and biogenesis;other biological processes","other membranes;nucleus","nucleic acid binding activity","LEMD3","ENSG00000174106","","RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOG GTPase cycle; RND2 GTPase cycle; RHOD GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; Initiation of Nuclear Envelope (NE) Reformation; Depolymerisation of the Nuclear Lamina","Envelope proteins and their potential roles in EDMD physiopathology",5215.2,5343.6,5244.4,5421.7,5449.2,6775,0.8955734759915899,-0.15911629405510444,0.24248883727546033,0.6153082489019367,0.47224911048397006,0.3258288514310461,3753]
["Q9Y2V2","Calcium-regulated heat-stable protein 1 [OS=Homo sapiens]",29,4,22,4,147,15.9,8.21,91.27,"signal transduction;other biological processes","cytosol;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","CARHSP1","ENSG00000153048","","","",3041.8,3034.7,2928.8,2641.4,2660.6,2835.7,1.10661489118547,0.14615324267873897,0.015767482454888366,1.802237643591304,0.12748288635263172,0.8945481121826941,904]
["Q9Y2V7-1","Conserved oligomeric Golgi complex subunit 6 [OS=Homo sapiens]",7,5,6,5,657,73.2,5.76,14.61,"other metabolic processes;transport","other membranes;ER/Golgi","","COG6","ENSG00000133103","","Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network; COPI-mediated anterograde transport","",308.7,329.6,341.5,313.5,311.1,765.2,0.7049935242480931,-0.5043180892597184,0.41737734584820246,0.37947112700060565,0.5924666966021581,0.22733605694386733,5149]
["Q9Y2W1","Thyroid hormone receptor-associated protein 3 [OS=Homo sapiens]",38,42,191,41,955,108.6,10.15,496.99,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","THRAP3","ENSG00000054118","","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","Interactome of polycomb repressive complex 2 (PRC2)",29260.8,28586.8,27719.3,26341.1,28273.6,22863.1,1.1044053909636051,0.14326983532173868,0.1764566194759366,0.7533620451648791,0.40969549928514,0.38753880696793314,3148]
["Q9Y2W2","WW domain-binding protein 11 [OS=Homo sapiens]",17,12,38,12,641,70,8.38,88.86,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","WBP11","ENSG00000084463","Spliceosome","mRNA Splicing - Major Pathway","",4675.5,4558,4539.8,6116.1,6297.7,6088.9,0.7443940614072541,-0.4258615489106087,3.5606599193214818E-5,4.448469504060957,0.008395117209780874,2.075973236011256,31]
["Q9Y2W6","tudor and KH domain-containing protein [OS=Homo sapiens]",27,12,19,12,561,62,5.02,53.9,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","mitochondrion;other cell component","nucleic acid binding activity","TDRKH","ENSG00000182134","","PIWI-interacting RNA (piRNA) biogenesis","",2123.7,2045.3,2053.9,2171.1,2042.3,2490.2,0.9282922608747538,-0.10734900404615282,0.3022527722986553,0.51962970704788,0.5231270454015798,0.2813928265888148,4223]
["Q9Y2X0-1","Mediator of RNA polymerase II transcription subunit 16 [OS=Homo sapiens]",7,7,8,7,877,96.7,7.37,15.28,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","MED16","ENSG00000175221","Thyroid hormone signaling pathway","Transcriptional regulation of white adipocyte differentiation; Generic Transcription Pathway; PPARA activates gene expression","",768.1,763.4,765.8,807.2,817.6,1086.3,0.8473682269189627,-0.23893906074046467,0.20560865977885207,0.6869585977751637,0.44147875861446234,0.3550901873037409,3404]
["Q9Y2X3","Nucleolar protein 58 [OS=Homo sapiens]",52,27,199,27,529,59.5,8.92,613.24,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NOP58","ENSG00000055044","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; SUMOylation of RNA binding proteins; rRNA modification in the nucleus and cytosol","",27420.5,27814.1,27487.2,24997,25124,15352.5,1.263439406782897,0.3373564758141334,0.15049906548581896,0.8224661967851687,0.38128168791537287,0.418754052392946,2885]
["Q9Y2X7-1","ARF GTPase-activating protein GIT1 [OS=Homo sapiens]",27,17,25,15,761,84.3,6.8,70.26,"developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","GIT1","ENSG00000108262","Endocytosis; Regulation of actin cytoskeleton; Epithelial cell signaling in Helicobacter pylori infection","RHOJ GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOU GTPase cycle; CDC42 GTPase cycle; RHOQ GTPase cycle; RHOV GTPase cycle; Ephrin signaling; Activation of RAC1 downstream of NMDARs","CAMKK2 pathway; Regulation of actin cytoskeleton",2095,2134.9,2154.8,2088.4,2070.2,1963.3,1.0429278491971445,0.06063935420861445,0.11009776413039596,0.95822150060764,0.3296618426993298,0.4819313181408557,2441]
["Q9Y2X9","Zinc finger protein 281 [OS=Homo sapiens]",1,1,2,1,895,96.9,8.48,4.27,"developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF281","ENSG00000162702","","","Mesodermal commitment pathway",66.6,79.8,68.7,95.8,122.9,102.6,0.669467787114846,-0.578913456048351,0.01776763876035824,1.7503702841521693,0.13598290230309779,0.8665156938519427,955]
["Q9Y2Y0","ADP-ribosylation factor-like protein 2-binding protein [OS=Homo sapiens]",34,5,13,5,163,18.8,4.35,30.82,"signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","ARL2BP","ENSG00000102931","","Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane","Ciliopathies",1250.1,1200.6,1232.4,1387.7,1358.9,869.9,1.0184155951887182,0.026326416780382673,0.9016173193637738,0.04497775442437941,0.9378000551059944,0.02788974607762522,7027]
["Q9Y2Y9","Krueppel-like factor 13 [OS=Homo sapiens]",9,2,2,1,288,31.2,9.54,6.01,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KLF13","ENSG00000169926; ENSG00000275746","","","15q13.3 copy number variation syndrome",97.7,82.8,68.1,195,197.1,225.9,0.4022653721682848,-1.313780541739252,7.201501821126646E-4,3.1425769251500952,0.029080539674372737,1.5363975381353068,181]
["Q9Y2Z0-1","Protein SGT1 homolog [OS=Homo sapiens]",46,14,43,14,365,41,5.16,124.5,"cell cycle OR cell proliferation;other biological processes","cytosol;nucleus;other cell component","other molecular function","SUGT1","ENSG00000165416; ENSPTRG00000005906","NOD-like receptor signaling pathway","The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection","Nucleotide-binding oligomerization domain (NOD) pathway",5356,5318.7,5604.7,5475.8,5403.5,4255.8,1.0756057112275441,0.10514932073415263,0.3998638652763184,0.3980878402279507,0.5814972127545983,0.23545236260053487,5026]
["Q9Y2Z2-6","Isoform 7 of Protein MTO1 homolog, mitochondrial [OS=Homo sapiens]",10,6,7,6,732,81.5,8.16,15.6,"","","","MTO1","","","","",264.8,265.5,261.9,304.9,309.6,282.4,0.8832645779908574,-0.17908243936859805,0.014582761484009272,1.8361602274784927,0.12307783335637848,0.9098201576118663,866]
["Q9Y2Z4","Tyrosine--tRNA ligase, mitochondrial [OS=Homo sapiens]",27,10,15,10,477,53.2,8.98,35.42,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;mitochondrion;nucleus","nucleic acid binding activity;other molecular function","YARS2","ENSG00000139131","Aminoacyl-tRNA biosynthesis","Mitochondrial tRNA aminoacylation","Orexin receptor pathway",1321.8,1343.6,1326.5,1303.9,1286.9,1083,1.086586096140236,0.11980249164159962,0.21107118492539326,0.6755710517803062,0.44716501177382584,0.34953218496960736,3450]
["Q9Y2Z9-1","Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial [OS=Homo sapiens]",6,3,4,3,468,50.8,7.3,4.76,"other metabolic processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","COQ6","ENSG00000119723","Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways; Biosynthesis of cofactors","Ubiquinol biosynthesis","Nephrotic syndrome",377.3,404.4,417.3,336.2,279.4,198.9,1.47206875383671,0.5578450548887063,0.036735900802464465,1.4349093063370109,0.18763291332299986,0.7266909782128143,1431]
["Q9Y303","N-acetylglucosamine-6-phosphate deacetylase [OS=Homo sapiens]",22,7,18,1,409,43.7,6.7,58.49,"other metabolic processes","cytosol","other molecular function","AMDHD2","ENSG00000162066","Amino sugar and nucleotide sugar metabolism; Metabolic pathways","Synthesis of UDP-N-acetyl-glucosamine","",115.2,114.5,108.5,116.2,133.1,132.4,0.8860361540476813,-0.17456252680557507,0.07036168249898699,1.1526637841763518,0.26292103138297335,0.5801746727439614,1956]
["Q9Y303-3","Isoform 3 of N-acetylglucosamine-6-phosphate deacetylase [OS=Homo sapiens]",19,8,18,2,594,63.6,7.53,56.95,"","","","AMDHD2","","","","",1468.2,1610,1594.5,1541.1,1527.1,2130.1,0.8988900217378759,-0.1537834805928355,0.4382756447647764,0.35825266267515843,0.6041789301368824,0.21883442418826007,5302]
["Q9Y305-1","Acyl-coenzyme A thioesterase 9, mitochondrial [OS=Homo sapiens]",34,14,39,14,439,49.9,8.6,116.05,"other metabolic processes","mitochondrion","other molecular function","ACOT9","ENSG00000123130","","Mitochondrial Fatty Acid Beta-Oxidation","VEGFA-VEGFR2 signaling pathway",2951.2,2939.4,2975,2837.9,2676.8,3382.1,0.9964931211222012,-0.005068248836717573,0.9635073553126021,0.016144965638021754,0.9787734899207517,0.009317802026672794,7195]
["Q9Y312","Protein AAR2 homolog [OS=Homo sapiens]",24,6,14,6,384,43.4,5.96,36.75,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","","AAR2","ENSG00000131043","","","Ciliary landscape",1119.7,1097.2,1099.3,1128.1,1185.6,1205,0.9424503367721033,-0.08551149855419601,0.049226330461864955,1.3078025371616497,0.21952120155324648,0.6585235288481759,1639]
["Q9Y314","nitric oxide synthase-interacting protein [OS=Homo sapiens]",45,8,17,8,301,33.2,8.82,55.24,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","NOSIP","ENSG00000142546","","NOSIP mediated eNOS trafficking","",1223.5,1177.3,1197.9,1297,1334,865.9,1.029111498756041,0.04139929903265758,0.8330336096171393,0.0793374761720797,0.8911947676656428,0.05002737196905539,6832]
["Q9Y315","deoxyribose-phosphate aldolase [OS=Homo sapiens]",31,10,21,10,318,35.2,8.94,65.5,"other metabolic processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","DERA","ENSG00000023697","Pentose phosphate pathway; Metabolic pathways","Neutrophil degranulation; Pentose phosphate pathway","",2764.6,2780.2,2855,2670.1,2677.3,2588.8,1.0584158665356214,0.08190659409192748,0.01779111914185923,1.7497967319696643,0.13602017762327315,0.8663966623617915,956]
["Q9Y316-1","Protein MEMO1 [OS=Homo sapiens]",39,9,21,9,297,33.7,7.14,62.18,"other biological processes","","other molecular function","LOC111154137; LOC114499315; MEMO1","ENSANAG00000021250; ENSCANG00000020056; ENSCATG00000030724; ENSCCAG00000037443; ENSCHIG00000006439; ENSCJAG00000003208; ENSDLEG00000015222; ENSECAG00000019946; ENSFCAG00000001385; ENSG00000162959; ENSHGLG00000018935; ENSMMUG00000003908; ENSMNEG00000040106; ENSMODG00000047380; ENSPANG00000022798; ENSPCOG00000018130; ENSPCTG00005009736; ENSPTRG00000050445; ENSRFEG00010015180; ENSSSCG00000008515; ENSSSCG00070008027; ENSVURG00010020209; ENSVVUG00000007616","","ERBB2 Regulates Cell Motility; ERBB2 Regulates Cell Motility","",2186.9,2190.3,2234.9,2141.8,2131.2,1889.4,1.07297481500714,0.10161621338174003,0.14838771694640712,0.8286020470568229,0.37908627163973774,0.42126194297811265,2861]
["Q9Y320","Thioredoxin-related transmembrane protein 2 [OS=Homo sapiens]",40,11,38,11,296,34,8.69,125.59,"developmental processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","TMX2","ENSG00000213593","","","",5113.5,5361.9,5510,4534.8,4799.9,4497.3,1.1556824754193173,0.2087450707948363,0.008707343217154537,2.060114336627136,0.0965735532233422,1.0151417893371728,659]
["Q9Y333","U6 snRNA-associated Sm-like protein LSm2 [OS=Homo sapiens]",75,6,22,6,95,10.8,6.52,72.61,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LSM2","ENSG00000172850; ENSG00000204392; ENSG00000224979; ENSG00000225998; ENSG00000231502; ENSG00000236826","RNA degradation; Spliceosome","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease; mRNA Splicing - Minor Pathway","mRNA processing",2159.8,2318.6,2257.5,2644.8,2300,1727.3,1.0095622068014567,0.013729808815958642,0.9413350818400051,0.026255755647870208,0.9655091374078862,0.015243611778894028,7126]
["Q9Y365","START domain-containing protein 10 [OS=Homo sapiens]",12,2,4,2,291,33,7.12,6.11,"transport","other membranes;cytosol;cytoskeleton;other cell component","other molecular function","STARD10","ENSG00000214530","","Synthesis of PC","",11.7,13.3,7.7,17,12,3.9,0.993920972644377,-0.008796948237158861,0.98799372308668,5.245814559616555E-3,0.9930206438449592,3.0417228895546484E-3,7272]
["Q9Y371","Endophilin-B1 [OS=Homo sapiens]",28,12,35,11,365,40.8,6.04,97.7,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SH3GLB1","ENSG00000097033","Autophagy; Endocytosis","","Nanoparticle triggered autophagic cell death; Senescence and autophagy in cancer",3656.3,3741.4,3748.3,3687.5,3427,1953.7,1.2291303676584107,0.29763794321223386,0.2693598303492982,0.5696671701512525,0.49615700605418867,0.3043808717494206,3968]
["Q9Y375","Complex I intermediate-associated protein 30, mitochondrial [OS=Homo sapiens]",36,11,26,11,327,37.7,7.64,91.39,"cell organization and biogenesis;other metabolic processes","other membranes;cytosol;mitochondrion","other molecular function","NDUFAF1","ENSG00000137806","Thermogenesis","Complex I biogenesis","Mitochondrial immune response to SARS-CoV-2",2658.7,2694.7,2735,2697.6,2847.7,3446.4,0.8995406875229378,-0.1527395567568943,0.2602513030888773,0.5846070872818181,0.48748764076796613,0.3120363904563444,3902]
["Q9Y376","Calcium-binding protein 39 [OS=Homo sapiens]",45,16,38,16,341,39.8,6.89,98.08,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","CAB39","ENSG00000135932","mTOR signaling pathway; AMPK signaling pathway","Neutrophil degranulation; Energy dependent regulation of mTOR by LKB1-AMPK","AMP-activated protein kinase (AMPK) signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias",6261.5,6408.8,6639.5,6320.1,6471.8,6590.3,0.9962646139241158,-0.005399113143133158,0.8667744471422645,0.06209390033870862,0.9120723343165579,0.03997071742947917,6946]
["Q9Y383","Putative RNA-binding protein Luc7-like 2 [OS=Homo sapiens]",40,20,182,14,392,46.5,10.01,519.86,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","LUC7L2","ENSG00000146963","","","",20365.6,19951.4,20097.3,20480.8,21202.6,18635.2,1.0015865752852358,2.2871304230924682E-3,0.969100428677799,0.013631214321212504,0.9818623555871961,7.949390419583844E-3,7214]
["Q9Y385","ubiquitin-conjugating enzyme e2 j1 [OS=Homo sapiens]",33,9,26,9,318,35.2,6.74,93.82,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","UBE2J1","ENSG00000198833","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum; Parkinson disease; Pathways of neurodegeneration","Antigen processing: Ubiquitination & Proteasome degradation","Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway",1681.8,1639,1697.1,2608.3,2758.8,3543.6,0.5631319649410259,-0.8284550502786321,0.011099188000603714,1.9547087923625632,0.10977532489365703,0.9594952688734161,739]
["Q9Y388","RNA-binding motif protein, X-linked 2 [OS=Homo sapiens]",15,5,9,5,322,37.3,9.83,24.14,"RNA metabolism OR transcription;other metabolic processes","nucleus","","RBMX2","ENSG00000134597","","","",1278.5,1214.7,1264.5,1429.7,1465.7,1287.6,0.8983265598852498,-0.15468810572868222,0.06996158801656067,1.1551403412888122,0.26249961335371763,0.5808713319474359,1948]
["Q9Y394","Dehydrogenase/reductase SDR family member 7 [OS=Homo sapiens]",40,9,16,9,339,38.3,8.32,51.28,"","","other molecular function","DHRS7","ENSG00000100612","","","",1706.8,1756.7,1702.6,1497.4,1495,1290.3,1.2062717444602706,0.2705549488820664,0.014156478694306095,1.8490447603337108,0.12172906209021558,0.9146057241640305,850]
["Q9Y399","28S ribosomal protein S2, mitochondrial [OS=Homo sapiens]",12,5,13,5,296,33.2,9.26,31.26,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPS2","ENSG00000122140","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1908.8,1984.5,2170.7,1887.4,1788.1,1304.1,1.2177684954614827,0.2842398949894275,0.13931664139222188,0.855997003941097,0.3668102780748378,0.4355585038399414,2776]
["Q9Y3A0-1","Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial [OS=Homo sapiens]",15,4,6,4,265,29.6,9.17,14.49,"other metabolic processes","other membranes;mitochondrion;other cell component","","COQ4","ENSG00000167113","","","",184,159.5,173.3,188.1,200.5,285.5,0.7666518320723927,-0.3833565552071386,0.1704910568424988,0.7682983971161698,0.4026233067728025,0.39510108858833354,3095]
["Q9Y3A3","MOB-like protein phocein [OS=Homo sapiens]",46,7,22,7,225,26,5.78,49.1,"","other membranes;ER/Golgi;other cell component","other molecular function","MOB4","ENSG00000115540","","","",881.9,898.8,1012.2,1157.1,1134.6,928.1,0.8674141251009378,-0.20520715843392162,0.16382574160863292,0.7856178573971067,0.39531275847391817,0.4030591688459894,3029]
["Q9Y3A4","Ribosomal RNA-processing protein 7 homolog A [OS=Homo sapiens]",21,5,9,5,280,32.3,9.58,22.92,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","","RRP7A","ENSG00000189306","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",864.2,923.5,931.7,2353.5,2293.2,1679.8,0.42984272504544374,-1.2181192055425412,5.124772931379383E-3,2.2903253725812083,0.07446712794324437,1.1280353957531626,503]
["Q9Y3A5","Ribosome maturation protein SBDS [OS=Homo sapiens]",54,17,52,17,250,28.7,8.75,132.39,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;translation activity;nucleic acid binding activity","SBDS","ENSG00000126524","Ribosome biogenesis in eukaryotes","","",6337.8,6309.9,7108.4,7376.6,6836.8,6523.9,0.9526842935194069,-0.06992989086079107,0.4164301873364292,0.38045779568782423,0.5918118295240057,0.22781635812494133,5143]
["Q9Y3A6-1","Transmembrane emp24 domain-containing protein 5 [OS=Homo sapiens]",36,7,15,7,229,26,4.84,29.15,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED5","ENSG00000117500","","WNT ligand biogenesis and trafficking","",1991.2,2060.8,2136.7,1839.6,1838.2,1107.8,1.2931920762286861,0.3709365727834085,0.13155926929639952,0.8808785473315452,0.3567965489006991,0.4475793549703298,2695]
["Q9Y3B2","Exosome complex component csl4 [OS=Homo sapiens]",28,4,6,4,195,21.4,8.24,17.07,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","EXOSC1","ENSG00000171311","RNA degradation","Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease","",676.5,682.6,695,739.7,595.9,337.1,1.2280145871943564,0.2963276981250022,0.34163861634511955,0.4664330457180073,0.5473556876077332,0.26173036477466405,4562]
["Q9Y3B3-1","Transmembrane emp24 domain-containing protein 7 [OS=Homo sapiens]",33,6,21,6,224,25.2,6.89,52.45,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED7","ENSG00000134970; ENSPTRG00000017152","","COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic","Regulation of toll-like receptor signaling pathway",2556.7,2744.6,2677.8,2413.6,1963.2,2249.3,{"$f":"AVERAGE(S7106:U7106)/AVERAGE(V7106:X7106)","v":1.204192511432064},{"$f":"LOG(Y7106,2)","v":0.2680660508075199},{"$f":"TTEST(V7106:X7106,S7106:U7106,2,2)","v":0.034112238490728426},1.4670897806725474,{"$f":"AA7106*7309/AE7106","v":0.1825229510459254},0.738682518134088,1366]
["Q9Y3B4","Splicing factor 3B subunit 6 [OS=Homo sapiens]",11,1,1,1,125,14.6,9.38,2.98,"RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus","nucleic acid binding activity","SF3B6","ENSG00000115128","Spliceosome","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","",34.8,34.5,36.8,52.7,55.7,129.9,0.44523709609735623,-1.1673542952755063,0.155992333934938,{"$f":"-LOG10(AA7107)","v":0.80689674402734},0.38741011509699685,{"$f":"-LOG10(AC7107)","v":0.41182904424297806},2943]
["Q9Y3B6","ER membrane protein complex subunit 9 [OS=Homo sapiens]",8,1,3,1,208,23,5.91,12.27,"cell organization and biogenesis","other membranes;ER/Golgi;other cell component","","EMC9","ENSG00000100908; ENSG00000285377","","","",90.5,91.7,95.9,91.2,105.2,167.6,0.7640109890109891,-0.38833470573937157,0.2907231547376173,0.5365203773306702,0.5133837975301389,0.2895578418474572,4139]
["Q9Y3B7-1","39S ribosomal protein L11, mitochondrial [OS=Homo sapiens]",58,12,42,12,192,20.7,9.91,125.25,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL11","ENSG00000174547; ENSPPAG00000028194; ENSPTRG00000003924","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",6126.6,5600.4,6056.7,5465.8,6521.3,4421.4,1.083810220312643,0.11611215689135418,0.5060333885475687,0.29582082706616836,0.6520800488177327,0.18569908735720553,5672]
["Q9Y3B8-1","Oligoribonuclease, mitochondrial [OS=Homo sapiens]",32,6,20,6,237,26.8,6.87,64.33,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","REXO2","ENSG00000076043; ENSPPAG00000039849; ENSPTRG00000004306","Ribosome biogenesis in eukaryotes","","",1411.4,1262.2,1459.8,2298.5,2291.8,2560.6,0.5780251436882072,-0.7907958445743608,7.0411491956054516E-4,3.152356453275596,0.028750703614905167,1.5413515223715162,179]
["Q9Y3B9","RRP15-like protein [OS=Homo sapiens]",16,5,12,5,282,31.5,5.52,20.14,"RNA metabolism OR transcription;other metabolic processes","other cell component","","RRP15","ENSG00000067533","","","",1772.7,1781.4,1706.5,2733.3,2804.3,1870,0.7101625357740698,-0.4937788410880517,0.07633617556453141,1.1172696019560313,0.2737689436708342,0.562615819742466,2038]
["Q9Y3C0","WASH complex subunit 3 [OS=Homo sapiens]",17,2,3,2,194,21.2,4.46,8.94,"cell organization and biogenesis;transport","other cytoplasmic organelle;other cell component","","WASHC3","ENSG00000120860","Endocytosis","","",330,336.3,371.3,473,479.8,205,0.8961824149248574,-0.1581356769771795,0.6837410308216939,0.1651083576094365,0.7834242348762753,0.10600299787592406,6379]
["Q9Y3C1","nucleolar protein 16 [OS=Homo sapiens]",14,3,4,3,178,21.2,9.94,6.24,"other biological processes","nucleus;other cell component","","NOP16","ENSG00000048162","","","",387.1,378.8,356,533.5,442.7,562.8,0.7289798570500325,-0.4560491438955253,0.020394845555003493,1.6904795791364777,0.14319493387273827,0.8440723467630409,1041]
["Q9Y3C4","EKC/KEOPS complex subunit TPRKB [OS=Homo sapiens]",25,3,10,3,175,19.6,6.79,31.28,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","TPRKB","ENSG00000144034","","tRNA modification in the nucleus and cytosol","",934.6,940.7,997,1014.4,967.4,741.5,1.0547130319832556,0.07685052153773628,0.5967661512860591,0.22419581812013734,0.7175133738690255,0.1441699996206055,6079]
["Q9Y3C6","Peptidyl-prolyl cis-trans isomerase-like 1 [OS=Homo sapiens]",34,5,30,5,166,18.2,7.99,62.77,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","PPIL1","ENSG00000137168","Spliceosome","mRNA Splicing - Major Pathway","",4114.5,4026,4060.7,4385.9,4618.2,5330.9,0.8511475409836067,-0.23251885933847227,0.06737063062371668,1.1715293874088106,0.2563310459285503,0.5911987903865312,1921]
["Q9Y3C8","ubiquitin-fold modifier-conjugating enzyme 1 [OS=Homo sapiens]",38,8,27,8,167,19.4,7.4,79.1,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes","","other molecular function","UFC1","ENSG00000143222","","","",4234,3792,4287.7,5314.4,5642.1,4971.8,0.7730705725030291,-0.37132797316576815,8.433886008836898E-3,2.0739722731418424,0.09571936776178398,1.0190001786176817,644]
["Q9Y3D0","Mitotic spindle-associated MMXD complex subunit MIP18 [OS=Homo sapiens]",13,1,2,1,163,17.7,5.19,7.54,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","","CIAO2B","ENSG00000166595","","Cytosolic iron-sulfur cluster assembly","",48.6,43.5,50.1,66.6,68,98.4,0.6103004291845493,-0.7124084899222275,0.04570846711227332,1.3400033430476608,0.21198171708350613,0.6737015943172244,1576]
["Q9Y3D2","Methionine-R-sulfoxide reductase B2, mitochondrial [OS=Homo sapiens]",16,1,1,1,182,19.5,8.63,5.54,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response","cytosol;mitochondrion;other cell component","cytoskeletal activity;other molecular function","MSRB2","ENSG00000148450","","Protein repair","Sulindac metabolic pathway; Methionine de novo and salvage pathway",71.1,68.3,61.7,61.5,71.3,129.9,0.7655119908641033,-0.38550311882828053,0.3943556756643996,0.4041119043194014,0.5786680653344904,0.23757048416781185,4981]
["Q9Y3D3","28S ribosomal protein S16, mitochondrial [OS=Homo sapiens]",34,4,10,4,137,15.3,9.5,31.7,"protein metabolism;other metabolic processes","other membranes;cytosol;mitochondrion;translational apparatus","other molecular function","MRPS16","ENSG00000182180","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",942.9,855.2,911.4,1015.8,1111.7,910.5,0.8918696510862409,-0.1650952227160543,0.15978549616599463,0.7964626444271936,0.3912469653190133,0.4075490180086085,2985]
["Q9Y3D6","mitochondrial fission 1 protein [OS=Homo sapiens]",20,3,14,3,152,16.9,8.79,36.07,"cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","FIS1","ENSG00000214253","Mitophagy","Class I peroxisomal membrane protein import","CAMKK2 pathway",952.2,935.8,1066.2,810,942.1,613.5,1.2488163679404802,0.3205613516147251,0.13199816064565087,0.8794321205139208,0.35772137788619285,0.44645510508283914,2697]
["Q9Y3D8","Adenylate kinase isoenzyme 6 [OS=Homo sapiens]",47,5,11,5,172,20,4.58,41.12,"other metabolic processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","AK6","ENSG00000085231; ENSG00000279247","Purine metabolism; Metabolic pathways; Biosynthesis of cofactors; Ribosome biogenesis in eukaryotes","Interconversion of nucleotide di- and triphosphates","",728.6,702.3,814.1,1085.3,917.8,1281.6,0.6834718543550402,-0.5490461665929278,0.034888048265406764,1.4573233255152844,0.18358296959816994,0.7361676093689271,1389]
["Q9Y3D9","28S ribosomal protein S23, mitochondrial [OS=Homo sapiens]",19,4,5,4,190,21.8,8.9,13.39,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus","other molecular function","MRPS23","ENSG00000181610","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",856.4,901.8,855.9,989.6,990.3,417.1,1.0905715477680433,0.12508442217866625,0.7247824049729178,0.13979235826160025,0.8127392755365229,0.09004875250675266,6518]
["Q9Y3E0","vesicle transport protein GOT1B [OS=Homo sapiens]",25,4,27,4,138,15.4,10.36,67.71,"transport","other membranes;ER/Golgi;other cell component","","GOLT1B","ENSG00000111711","","","",1938.4,2111.1,2201.8,1868.5,1967.7,2015.4,1.0683061043133502,0.09532508513435553,0.20685295979439527,0.6843382605399119,0.4428495264022364,0.3537438154346537,3414]
["Q9Y3E1","Hepatoma-derived growth factor-related protein 3 [OS=Homo sapiens]",18,3,6,2,203,22.6,7.99,12.72,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;nucleus","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function","HDGFL3","ENSG00000166503","","","",217.8,200.8,201.2,165.9,180.7,340.5,0.9020521030417697,-0.1487173281150893,0.7100497784902438,0.14871120372342828,0.8015063831637361,0.09609301459274477,6475]
["Q9Y3E2","BolA-like protein 1 [OS=Homo sapiens]",9,1,1,1,137,14.3,7.96,2.23,"","mitochondrion","","BOLA1","ENSG00000178096","","","",52.9,55.7,60.2,39.9,54.3,19,1.4911660777385163,0.5764409458753033,0.15129371049132964,0.8201791258808775,0.38223495678573394,0.4176695976448874,2893]
["Q9Y3E5","Peptidyl-tRNA hydrolase 2, mitochondrial [OS=Homo sapiens]",56,7,11,7,179,19.2,8.73,36.93,"other biological processes","cytosol;mitochondrion","other molecular function","PTRH2","ENSG00000141378","","Ub-specific processing proteases","",1160.9,1110.4,1093.2,1101,1162.5,819.9,1.091165596419537,0.1258700631684797,0.4321870997590928,0.3643282004029261,0.6005428730302679,0.2214559826726922,5260]
["Q9Y3E7","Charged multivesicular body protein 3 [OS=Homo sapiens]",9,2,2,2,222,25.1,5.12,5.28,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","CHMP3","ENSG00000115561","Endocytosis; Necroptosis","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","",81.1,88.9,92.6,73,85.2,107,0.9901960784313728,-0.014213859219700479,0.9382195649781506,0.02769551481941481,0.963395167241543,0.016195536603268963,7118]
["Q9Y3F4","Serine-threonine kinase receptor-associated protein [OS=Homo sapiens]",63,16,105,16,350,38.4,5.12,381.28,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","STRAP","ENSG00000023734","","Downregulation of TGF-beta receptor signaling","TGF-beta signaling pathway; Epithelial to mesenchymal transition in colorectal cancer",10689.6,10670.4,10547,11101.9,10678.4,10899.1,0.9763643151343048,-0.03450852746142266,0.11913839917351357,0.9239482396810244,0.3437751912985435,0.46372546758759936,2533]
["Q9Y3I0","tRNA-splicing ligase RtcB homolog [OS=Homo sapiens]",68,26,142,26,505,55.2,7.23,472.97,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","cytoskeletal activity;other molecular function","RTCB","ENSG00000100220","","tRNA processing in the nucleus","Unfolded protein response",16736.5,17233.4,17427.5,17112.9,16675.2,13862.5,1.0786306992986447,0.1092010006110593,0.29562378390610505,0.5292606284515741,0.517040975489285,0.28647503771122695,4179]
["Q9Y3I1","F-box only protein 7 [OS=Homo sapiens]",5,2,4,2,522,58.5,6.55,8.54,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","FBXO7","ENSG00000100225","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",463.5,487.2,470.8,552.5,524.8,452.7,0.9290849673202614,-0.10611755390248682,0.30214410852585716,0.5197858695924422,0.5230628349634036,0.2814461366801069,4222]
["Q9Y3L3-1","SH3 domain-binding protein 1 [OS=Homo sapiens]",18,12,33,12,701,75.7,6.77,85.44,"cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","SH3BP1","ENSG00000100092","","RAC1 GTPase cycle","",3207.3,3183.1,3137.5,3053.2,3248.6,2645.7,1.0648672813635094,0.09067363284529861,0.3400420142203784,0.4684674199671841,0.5468354415702411,0.26214334564119735,4545]
["Q9Y3L5","ras-related protein Rap-2c [OS=Homo sapiens]",46,8,43,4,183,20.7,4.94,126.77,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","RAP2C","ENSG00000123728","Tight junction","Neutrophil degranulation","",1337,1419,1415.5,1119.4,1273.1,966,1.2420723537293434,0.31274921649408943,0.04296831157404621,1.3668517114424996,0.20446314407207275,0.6893849652540198,1536]
["Q9Y3M8-4","Isoform 4 of StAR-related lipid transfer protein 13 [OS=Homo sapiens]",1,1,3,1,1078,120.6,6.95,6.05,"","","","STARD13","","","","",365.6,478.2,355.9,369.8,438,248.1,1.136187138933611,0.18420047760314234,0.5198042159222237,0.2841602024334425,0.662351641243991,0.1789113832092133,5736]
["Q9Y3P4","rhomboid domain-containing protein 3 [OS=Homo sapiens]",3,1,3,1,386,40.5,6.58,7.94,"protein metabolism;developmental processes;signal transduction;other biological processes","other membranes","other molecular function","RHBDD3","ENSG00000100263","","","",102.2,101.9,114.1,97.9,100.5,223.6,0.7540284360189575,-0.4073091632634995,0.45301048873919164,0.3438917424710127,0.6129310740827012,0.2125883604384718,5402]
["Q9Y3P9","Rab GTPase-activating protein 1 [OS=Homo sapiens]",31,26,56,23,1069,121.7,5.25,167.69,"cell cycle OR cell proliferation;transport;other biological processes","cytosol;cytoskeleton","enzyme regulator activity;cytoskeletal activity;other molecular function","RABGAP1","ENSG00000011454","","TBC/RABGAPs","",6128.1,5932.5,5859.4,5691.8,6178.7,5403.9,1.0373732228036863,0.05293503572886033,0.4204359446188559,0.37630016162024044,0.5933512877426564,0.22668811075416154,5179]
["Q9Y3Q3","Transmembrane emp24 domain-containing protein 3 [OS=Homo sapiens]",12,3,7,3,217,24.8,5.6,19.5,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED3","ENSG00000166557","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport","",974.6,963.7,994.9,867.8,797,536,1.3327880770628864,0.41444739972427197,0.07356430417414506,1.133332868553122,0.26897523722302463,0.570287700787266,1999]
["Q9Y3Q8","TSC22 domain family protein 4 [OS=Homo sapiens]",32,8,19,6,395,41,7.21,54.61,"stress response;other biological processes","nucleus","","TSC22D4","ENSG00000166925","","","",1730.4,1634.1,1655.4,1834.1,1933.2,1824.7,0.8976931330472103,-0.15570573576858796,0.01364916102291524,1.864894042712334,0.12033982860854946,0.9195906113786344,829]
["Q9Y3R5-1","Protein dopey-2 [OS=Homo sapiens]",3,5,5,5,2298,258.1,6.29,14.93,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","","DOP1B","ENSG00000142197","","","",574.5,551.5,598,543.6,547.4,430.1,1.1333903096443363,0.18064477273757343,0.1723625572566812,0.7635570711267965,0.40481938656461536,0.39273869756047486,3112]
["Q9Y3S2","zinc finger protein 330 [OS=Homo sapiens]",27,8,24,8,320,36.2,6.16,60.9,"","nucleus;other cell component","other molecular function","ZNF330","ENSG00000109445","","","",2485.6,2125.9,2061.5,2946.2,2560.4,4084.6,0.695741930102594,-0.5233758250257551,0.11059051771896765,0.956282108825813,0.33046038185115884,0.48088059964210667,2446]
["Q9Y3T6","R3H and coiled-coil domain-containing protein 1 [OS=Homo sapiens]",21,7,9,7,440,49.1,5.63,30.34,"","","nucleic acid binding activity","R3HCC1","ENSG00000104679","","","",1131.2,1180.6,1221,1403.8,1450.8,1583.1,0.7960880636365686,-0.3290000636857843,0.007187337034665108,2.1434319893629117,0.08784656586349043,1.0562752114673497,598]
["Q9Y3T9","Nucleolar complex protein 2 homolog [OS=Homo sapiens]",24,16,48,16,749,84.9,5.62,133.65,"cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","other molecular function","NOC2L","ENSG00000188976","","Regulation of TP53 Activity through Phosphorylation","",4995.8,5313.1,5227.3,5637.9,5219.9,4016.2,1.0445206400430282,0.06284100077602604,0.6788821005911319,0.16820564178514566,0.7792005768248402,0.10835073463078533,6368]
["Q9Y3U8","60S ribosomal protein L36 [OS=Homo sapiens]",21,2,5,2,105,12.2,11.59,14.47,"protein metabolism;other metabolic processes","cytosol;translational apparatus;nucleus","other molecular function","RPL36","ENSG00000130255","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",422.1,401.9,372.9,417.6,415.4,464.6,0.9223951911220717,-0.11654310332268213,0.19314110180463379,0.7141252954206065,0.4272603853178173,0.3693073721849782,3304]
["Q9Y3X0","coiled-coil domain-containing protein 9 [OS=Homo sapiens]",17,9,13,9,531,59.7,5.4,33.02,"","","","CCDC9","ENSG00000105321","","","IL-18 signaling pathway",2736.7,2912.1,2523.4,3671.6,3065.9,1727.5,0.965410513880685,-0.050785556233157975,0.8756421350362507,0.05767334877899612,0.9184943118513139,0.03692352889462999,6968]
["Q9Y3Z3","deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [OS=Homo sapiens]",60,33,158,33,626,72.2,7.14,474.84,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","plasma membrane;other membranes;nucleus;other cell component","nucleic acid binding activity;other molecular function","SAMHD1","ENSG00000101347","Human immunodeficiency virus 1 infection","Interferon alpha/beta signaling; Nucleotide catabolism","",20662.1,20193.7,20756.1,18719.7,18668.2,15829.7,1.157735410841526,0.21130557708980632,0.04488094319198544,1.3479380247739445,0.20987512078708992,0.6780390409091585,1563]
["Q9Y448","Small kinetochore-associated protein [OS=Homo sapiens]",3,1,1,1,316,35.4,6.3,0,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KNSTRN","ENSG00000128944","","","Overview of leukocyte-intrinsic Hippo pathway functions",162.7,166.6,150.6,182.9,219.5,132.7,0.8968417118295647,-0.1570747158851684,0.5122956595037307,0.29047932372850793,0.6573681487557527,0.18219134247333496,5696]
["Q9Y450-1","HBS1-like protein [OS=Homo sapiens]",41,23,81,23,684,75.4,6.61,246.97,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol","nucleic acid binding activity;other molecular function","HBS1L","ENSG00000112339","mRNA surveillance pathway; Legionellosis","mRNA decay by 3' to 5' exoribonuclease","",7846.8,7881.9,7828.3,8128.4,7925.3,7937.2,0.9819139757157921,-0.026331457561739168,0.09934137628417063,1.0028698275451398,0.3124294833308963,0.50524798937946,2324]
["Q9Y478","5'-AMP-activated protein kinase subunit beta-1 [OS=Homo sapiens]",24,4,7,4,270,30.4,6.4,23.12,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","PRKAB1","ENSG00000111725","FoxO signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Apelin signaling pathway; Tight junction; Circadian rhythm; Thermogenesis; Insulin signaling pathway; Adipocytokine signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Insulin resistance; Non-alcoholic fatty liver disease; Alcoholic liver disease; Hypertrophic cardiomyopathy","Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Lipophagy","AMP-activated protein kinase (AMPK) signaling; Target of rapamycin (TOR) signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Angiopoietin-like protein 8 regulatory pathway; Leptin and adiponectin; Lipid metabolism pathway; Genotoxicity pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; Malignant pleural mesothelioma",277.2,291.4,288.9,284,271.2,528.7,0.791124642494695,-0.33802308420606264,0.41922833531354015,0.3775493714097495,0.5929063279424661,0.22701391451280417,5168]
["Q9Y483","Metal-response element-binding transcription factor 2 [OS=Homo sapiens]",8,3,3,3,593,67.1,8.72,9.82,"","","","","","","","",224.7,224.2,222.5,283,283.3,305.6,0.7700424360591811,-0.3769901418003907,8.826538884029679E-4,3.054209561228718,0.03193721420959056,1.4957029687913688,202]
["Q9Y484-1","WD repeat domain phosphoinositide-interacting protein 4 [OS=Homo sapiens]",3,1,3,1,360,39.8,7.14,9.19,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response","other membranes;cytosol;other cell component","other molecular function","WDR45","ENSCANG00000035794; ENSCSAG00000012964; ENSG00000196998; ENSGGOG00000000589; ENSMFAG00000032970; ENSMLEG00000042347; ENSMMUG00000010620","","Macroautophagy","Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway",367.8,354.6,340.2,393.7,394.5,803.6,0.6675461741424803,-0.5830604634767814,0.26654288887752503,0.5742328995672575,0.4937055181971187,0.30653201859945695,3946]
["Q9Y485","DmX-like protein 1 [OS=Homo sapiens]",10,21,31,21,3027,337.6,6.34,93.99,"other biological processes","other cell component","","DMXL1","ENSG00000172869","","","",1806.7,1855.4,1904.2,2034.3,1931.5,1955.9,0.939983450698279,-0.08929273789038311,0.04740309469388472,1.3241933046422694,0.21586867234741647,0.6658103794991872,1605]
["Q9Y487","V-type proton ATPase 116 kDa subunit a isoform 2 [OS=Homo sapiens]",11,8,18,7,856,98,6.61,37.74,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ATP6V0A2","ENSG00000185344","Oxidative phosphorylation; Metabolic pathways; Lysosome; Phagosome; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Tuberculosis; Human papillomavirus infection; Rheumatoid arthritis","ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","",798.7,798.8,794.6,784.2,770.8,1132,0.8902493487160402,-0.16771861973792637,0.4525106969525173,0.3443711500001221,0.612822064855651,0.21266560618136296,5397]
["Q9Y490","Talin-1 [OS=Homo sapiens]",70,136,676,115,2541,269.6,6.07,2295.38,"cell adhesion;cell organization and biogenesis;signal transduction","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","TLN1","ENSG00000137076","Rap1 signaling pathway; Focal adhesion; Platelet activation; Shigellosis; Human T-cell leukemia virus 1 infection","Platelet degranulation ; p130Cas linkage to MAPK signaling for integrins; Signaling by BRAF and RAF1 fusions; XBP1(S) activates chaperone genes; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Smooth Muscle Contraction; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins","Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion",75116.2,75079.9,76136.2,73253.2,73499.4,77350.4,1.0099476579965463,0.014280525149764398,0.6166005408648774,0.20999609865828014,0.732206881101769,0.13536619404164232,6155]
["Q9Y496","kinesin-like protein KIF3A [OS=Homo sapiens]",11,7,14,7,699,80,6.54,27.19,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF3A","ENSG00000131437","Hedgehog signaling pathway","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Hedgehog 'off' state; Activation of SMO","Hedgehog signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Insulin signaling",942.6,967.1,1041.1,878.7,984.9,1451.3,0.8901625991734292,-0.16785920870125215,0.5335062954491889,0.2728604514734147,0.6726578425803211,0.17220578996021343,5797]
["Q9Y4A5","Transformation/transcription domain-associated protein [OS=Homo sapiens]",9,29,55,29,3859,437.3,8.19,157.22,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","ER/Golgi;nucleus","other molecular function","TRRAP","ENSG00000196367","Human T-cell leukemia virus 1 infection","Ub-specific processing proteases; HATs acetylate histones; Formation of the beta-catenin:TCF transactivating complex","Rett syndrome causing genes",3437.7,3410.4,3331.1,4027.6,3916.3,5737.7,0.7440065489416444,-0.4266127745163528,0.11911954610318862,0.9240169701018851,0.3438565412591649,0.4636227095632297,2532]
["Q9Y4B4","Helicase ARIP4 [OS=Homo sapiens]",5,5,5,5,1467,162.7,6.09,13.39,"cell organization and biogenesis","nucleus","nucleic acid binding activity;other molecular function","RAD54L2","ENSG00000164080","","","",147.6,164.9,160.8,213.9,197.5,1260.7,0.2830572334190539,-1.8208343032382437,0.31937370135770315,0.49570084845257845,0.5353904548677644,0.27132937583719147,4360]
["Q9Y4B5","Microtubule cross-linking factor 1 [OS=Homo sapiens]",11,17,21,15,1905,209.4,6.43,59.89,"cell organization and biogenesis;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MTCL1","ENSG00000168502","","","",1545.7,1517.3,1514.1,1862.9,1685.3,2081,0.8130995523342571,-0.29849609453508125,0.03791414116026664,1.4211987773032007,0.1905876600690432,0.7199052219422468,1454]
["Q9Y4B6","DDB1- and CUL4-associated factor 1 [OS=Homo sapiens]",14,17,24,17,1507,168.9,5.06,59.02,"protein metabolism;DNA metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","kinase activity;other molecular function","DCAF1","ENSG00000145041","Human immunodeficiency virus 1 infection","Antigen processing: Ubiquitination & Proteasome degradation","Hippo-Merlin signaling dysregulation",1872.6,1866.9,1783.1,2579.6,2545.3,2725.4,0.7034890386354663,-0.5074001505008281,2.3950695660495452E-4,3.620681867755607,0.017162317115937378,1.7654240776335517,102]
["Q9Y4C1","Lysine-specific demethylase 3A [OS=Homo sapiens]",4,4,5,4,1321,147.2,8.07,17.37,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KDM3A","ENSG00000115548","Thermogenesis","NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; HDMs demethylate histones","Thermogenesis; Male infertility; Vitamin D-sensitive calcium signaling in depression",324.6,304.7,336.9,360.8,345.1,322.8,0.939243705647905,-0.0904285522247138,0.22350498892929352,0.6507127783920842,0.4556758616692347,0.34134397651193016,3585]
["Q9Y4C2-1","TRPM8 channel-associated factor 1 [OS=Homo sapiens]",12,8,10,8,921,102.1,6.54,20.97,"other biological processes","plasma membrane;other membranes","other molecular function","TCAF1","ENSG00000198420","","","",713.7,718.8,699.4,703.6,754.2,665.7,1.0039557334589122,0.005695659201818134,0.9202937458911319,0.03607352933082468,0.9501945174061708,0.022187479775701836,7079]
["Q9Y4C8","Probable RNA-binding protein 19 [OS=Homo sapiens]",6,5,6,5,960,107.3,6.54,18.91,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","RBM19","ENSG00000122965","","","",274.7,292.2,280.6,429.6,476.6,568.1,0.5748490809197585,-0.7987448497646853,0.006994652853916527,2.155233834763236,0.0867978229359523,1.0614911676663643,589]
["Q9Y4D1","Disheveled-associated activator of morphogenesis 1 [OS=Homo sapiens]",8,9,12,9,1078,123.4,7.23,24.91,"cell-cell signaling;cell organization and biogenesis;signal transduction","plasma membrane;other membranes;cytosol;cytoskeleton","cytoskeletal activity;other molecular function","DAAM1","ENSG00000100592","Wnt signaling pathway","RHO GTPases Activate Formins; RHOA GTPase cycle; PCP/CE pathway; RHOC GTPase cycle; CDC42 GTPase cycle; RHOB GTPase cycle","Physico-chemical features and toxicity-associated pathways; Wnt signaling; Genotoxicity pathway",1311.5,1467.8,1314.3,1127.9,1187.2,1162.8,1.1770321170821472,0.23515368700590156,0.01959586460704571,1.7078355698595153,0.1415278403289497,0.8491581204793228,1012]
["Q9Y4D8-1","Probable E3 ubiquitin-protein ligase HECTD4 [OS=Homo sapiens]",1,2,2,1,3996,439.1,6.19,7.94,"protein metabolism;other metabolic processes;other biological processes","other membranes","other molecular function","HECTD4","","","","",18.1,16.2,18.6,18.2,16.3,26.2,0.871499176276771,-0.1984287941416564,0.4515496660321324,0.3452944745920637,0.6123147512112905,0.21302527789482945,5390]
["Q9Y4D8-5","Isoform 5 of Probable E3 ubiquitin-protein ligase HECTD4 [OS=Homo sapiens]",3,3,3,2,1321,145,5.78,9.3,"","","","HECTD4","","","","",113.4,91.8,87.8,111.9,93.2,410,0.4763453097057389,-1.0699203112940003,0.35580417861622726,0.4487889558043335,0.5557966961970517,0.25508403911254074,4679]
["Q9Y4E1","WASH complex subunit 2C [OS=Homo sapiens]",31,32,65,7,1318,144.6,4.79,199.88,"","","","","","","","",365.3,367.4,336.8,451,478.4,851.4,0.6005727762803235,-0.7355890152895528,0.14112598432458034,0.8503930159421372,0.3689162444307431,0.4330722211318081,2796]
["Q9Y4E5","E3 SUMO-protein ligase ZNF451 [OS=Homo sapiens]",13,11,16,11,1061,121.4,6.77,39.08,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","ZNF451","ENSG00000112200","","","",952,913.8,885.3,1007.2,845,1862.8,0.7405383580080754,-0.4333536294950536,0.3671886729506941,0.43511072439586057,0.5634646253614577,0.2491333440234781,4763]
["Q9Y4E6-1","WD repeat-containing protein 7 [OS=Homo sapiens]",5,5,8,5,1490,163.7,6.92,26.64,"","ER/Golgi","","WDR7","ENSG00000091157","","","",498.2,554.6,610.3,513.2,514.9,772.1,0.9238417953560717,-0.1142822785240195,0.6450982286507512,0.19037415061604246,0.7531985548256135,0.12309052194249916,6260]
["Q9Y4E8-3","Isoform 3 of Ubiquitin carboxyl-terminal hydrolase 15 [OS=Homo sapiens]",36,27,68,26,956,109.7,5.16,185.84,"","","","USP15","","","","",6668.6,6589.9,6696,6525.1,6498.2,6906.4,1.0012443739745205,1.794136105283299E-3,0.9543105671617087,0.02031026716678041,0.9729468454993623,0.011910885668843565,7169]
["Q9Y4F1","FERM, RhoGEF and pleckstrin domain-containing protein 1 [OS=Homo sapiens]",6,5,7,5,1045,118.6,8.15,21.83,"cell-cell signaling;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","FARP1","ENSG00000152767","","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOF GTPase cycle","",316.7,369.4,328.4,281.2,288.3,566.1,0.8933603381472349,-0.16268588908037038,0.6932311877706026,0.15912190704872892,0.7909501641297743,0.10185087949255892,6406]
["Q9Y4F3-1","Meiosis regulator and mRNA stability factor 1 [OS=Homo sapiens]",1,2,2,2,1742,192.7,7.87,4.99,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","ER/Golgi;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","MARF1","ENSG00000166783; ENSG00000277140","","","",199.8,209.1,209.5,240,228.1,183,0.9497772999539241,-0.0743388192504491,0.5702186151659681,0.24395860896290247,0.6998703372372898,0.15498241289772582,5955]
["Q9Y4G6","Talin-2 [OS=Homo sapiens]",8,22,62,2,2542,271.4,5.57,173.61,"cell adhesion;cell organization and biogenesis","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","TLN2","ENSG00000171914","Rap1 signaling pathway; Focal adhesion; Platelet activation; Shigellosis; Human T-cell leukemia virus 1 infection","","Focal adhesion",454.5,455.5,477.8,480.9,430.4,362.1,{"$f":"AVERAGE(S7170:U7170)/AVERAGE(V7170:X7170)","v":1.089838228365007},{"$f":"LOG(Y7170,2)","v":0.12411400247350991},{"$f":"TTEST(V7170:X7170,S7170:U7170,2,2)","v":0.34023760808383335},0.46821768343194686,{"$f":"AA7170*7309/AE7170","v":0.5466688673301248},0.26227565837792916,4549]
["Q9Y4G8","rap guanine nucleotide exchange factor 2 [OS=Homo sapiens]",6,7,11,5,1499,167.3,6.67,18.79,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","RAPGEF2","ENSG00000109756","MAPK signaling pathway; Rap1 signaling pathway; Tight junction","RAF/MAP kinase cascade","MAPK signaling pathway; Genotoxicity pathway",569.3,611.1,554.5,543.4,520.3,641.7,1.0172979946053715,0.024742346222167456,0.8218030239518918,{"$f":"-LOG10(AA7171)","v":0.08523226501719458},0.8827981043598437,{"$f":"-LOG10(AC7171)","v":0.05413860807375303},6804]
["Q9Y4H2","Insulin receptor substrate 2 [OS=Homo sapiens]",1,2,3,2,1338,137.2,8.65,4.13,"other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;other molecular function","IRS2","ENSG00000185950","cGMP-PKG signaling pathway; FoxO signaling pathway; Autophagy; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Regulation of lipolysis in adipocytes; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; Growth hormone synthesis, secretion and action; Alzheimer disease; MicroRNAs in cancer","Growth hormone receptor signaling; Interleukin-7 signaling; Signaling by Leptin; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); RAF/MAP kinase cascade; PI3K Cascade; PI3K/AKT activation; Erythropoietin activates Phospholipase C gamma (PLCG); Erythropoietin activates STAT5; Erythropoietin activates RAS; SOS-mediated signalling; IRS activation; Signal attenuation","Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Farnesoid X receptor pathway; Nuclear receptors meta-pathway; Transcription factor regulation in adipogenesis; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; Nonalcoholic fatty liver disease; Insulin signaling; FOXA2 pathway; Alzheimer's disease; EPO receptor signaling; Interferon type I signaling pathways",262.1,232.2,260,347.4,334,420.8,0.6843585556160405,-0.5471757012459626,0.015501258930512952,1.8096330292895577,0.12659072795879237,0.8975981027214968,895]
["Q9Y4I1-1","Unconventional myosin-Va [OS=Homo sapiens]",33,53,123,1,1855,215.3,8.48,353.17,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYO5A","ENSG00000197535","Pathogenic Escherichia coli infection","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Insulin processing; Translocation of SLC2A4 (GLUT4) to the plasma membrane","Joubert syndrome",115.5,119.4,98.1,118.4,109.5,173.9,0.8287705326032851,-0.2709553867746676,0.33991477872641757,0.46862995286382564,0.546991879725096,0.2620191208635691,4542]
["Q9Y4I1-3","Isoform 3 of Unconventional myosin-Va [OS=Homo sapiens]",32,53,122,1,1880,218.5,8.51,350.7,"","","","MYO5A","","","","",11404,11339.9,11432.1,11176,11246,10427.1,1.0403938007433995,0.05712970802349148,0.16853546997136964,0.7733086835658225,0.4005937398441433,0.39729584179328514,3075]
["Q9Y4J8-1","Dystrobrevin alpha [OS=Homo sapiens]",11,7,7,7,743,83.8,6.89,19.38,"cell-cell signaling;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","other molecular function","DTNA","ENSG00000134769","","","",563.4,523.5,526.6,578,597.4,532.9,0.9445062342679856,-0.08236777565029414,0.24152402879694768,0.6170396555758414,0.47162680376085775,0.32640152080629037,3743]
["Q9Y4K3","TNF receptor-associated factor 6 [OS=Homo sapiens]",20,7,9,7,522,59.5,6.44,27.18,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","TRAF6","ENSG00000175104","MAPK signaling pathway; NF-kappa B signaling pathway; Ubiquitin mediated proteolysis; Autophagy; Endocytosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; IL-17 signaling pathway; Neurotrophin signaling pathway; Alcoholic liver disease; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Yersinia infection; Leishmaniasis; Chagas disease; Toxoplasmosis; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis","Ub-specific processing proteases; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; TRAF6 mediated NF-kB activation; activated TAK1 mediates p38 MAPK activation; Ovarian tumor domain proteases; NRIF signals cell death from the nucleus; Regulated proteolysis of p75NTR; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; PIP3 activates AKT signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; TICAM1,TRAF6-dependent induction of TAK1 complex; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway; TRAF6 mediated IRF7 activation; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling","Regulation of toll-like receptor signaling pathway; IL-1 signaling pathway; RANKL/RANK signaling pathway; IL-17 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Melatonin metabolism and effects; Photodynamic therapy-induced NF-kB survival signaling; Interleukin-1 induced activation of NF-kB; TGF-beta signaling pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor (RLR) pathway; MYD88 distinct input-output pathway; ApoE and miR-146 in inflammation and atherosclerosis; Oxidative damage response; Fibrin complement receptor 3 signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; miRNAs involvement in the immune response in sepsis; Signal transduction through IL1R; Interactions between immune cells and microRNAs in tumor microenvironment; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; 16p11.2 proximal deletion syndrome; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Modulators of TCR signaling and T cell activation; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; T-cell receptor (TCR) signaling pathway; Toll-like receptor signaling pathway",847,1013.1,954,910.3,853.5,560.1,1.2109385085416755,0.27612560683704973,0.24134020912169932,0.6173703152860166,0.47164587927018725,0.3263839556025238,3740]
["Q9Y4K4","mitogen-activated protein kinase kinase kinase kinase 5 [OS=Homo sapiens]",2,1,1,1,846,95,7.64,3.44,"","","","","","","","",84.6,74.6,72.7,81.3,95.1,119.7,0.7831813576494429,-0.3525816705315501,0.14449850823736998,0.8401366364203932,0.37372243337117383,0.42745083204896,2826]
["Q9Y4L1","Hypoxia up-regulated protein 1 [OS=Homo sapiens]",63,51,778,51,999,111.3,5.22,2458.55,"stress response;transport;other biological processes","non-structural extracellular;ER/Golgi;other cell component","other molecular function","HYOU1","ENSG00000149428; ENSG00000280682","Protein processing in endoplasmic reticulum","XBP1(S) activates chaperone genes; Scavenging by Class F Receptors","VEGFA-VEGFR2 signaling pathway",76286,75361,75565.4,68812.9,71997.1,62815.2,1.1158363503142046,0.1581254555699895,0.04388885743976464,1.3576457250120397,0.20682376468551886,0.6843995609416716,1551]
["Q9Y4L5","E3 ubiquitin-protein ligase RNF115 [OS=Homo sapiens]",3,1,1,1,304,33.7,5.69,1.74,"protein metabolism;other metabolic processes;other biological processes","cytosol","other molecular function","RNF115","ENSG00000265491","","Antigen processing: Ubiquitination & Proteasome degradation","",52.4,65.7,50.6,97.7,110.1,177.6,0.4377270368448365,-1.1918965980081555,0.0460461726086259,1.3368064628402963,0.21287253358409028,0.6718803708885323,1581]
["Q9Y4P1-1","Cysteine protease ATG4B [OS=Homo sapiens]",23,6,17,6,393,44.3,5.07,57.73,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol","other molecular function","ATG4B","ENSG00000168397","Autophagy; Autophagy","Macroautophagy","",1269.5,1393.4,1250.1,1364.8,1383.3,1917.9,0.8386198028289755,-0.25391119708340515,0.2502822361956702,0.6015699733880537,0.4798827031359269,0.31886490347036955,3812]
["Q9Y4P3","Transducin beta-like protein 2 [OS=Homo sapiens]",37,17,53,17,447,49.8,9.44,156.95,"stress response;signal transduction","other membranes;ER/Golgi","other molecular function","TBL2","ENSG00000106638","","","7q11.23 copy number variation syndrome",7643.3,7637.4,7705.3,6861.3,6903.2,6922.4,1.1111379665392107,0.15203796279730378,1.0950745075020539E-5,4.960556330964345,6.156845827178856E-3,2.210641721387209,13]
["Q9Y4P8-1","WD repeat domain phosphoinositide-interacting protein 2 [OS=Homo sapiens]",28,8,18,1,454,49.4,6.46,61,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","WIPI2","ENSG00000157954","Autophagy; Autophagy; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis","Macroautophagy","Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Alzheimer's disease",941.9,1059,934.4,982.1,906.8,1595.2,0.8424844292643724,-0.24727807213074046,0.45566652827540166,0.34135287205214415,0.6150446269925967,0.21109337112951035,5415]
["Q9Y4P8-6","Isoform 6 of WD repeat domain phosphoinositide-interacting protein 2 [OS=Homo sapiens]",28,8,16,1,443,48.2,6.3,47.61,"","","","WIPI2","","","","",41.1,45.7,38.6,34.5,40.8,48.8,1.0104754230459307,0.015034232671682354,0.9299457014022945,0.031542408725417186,0.9577248318373073,0.01875925207033117,7097]
["Q9Y4R8","telomere length regulation protein TEL2 homolog [OS=Homo sapiens]",16,9,19,9,837,91.7,5.76,60.21,"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TELO2","ENSG00000100726","Fanconi anemia pathway; mTOR signaling pathway","","Fragile X syndrome; Malignant pleural mesothelioma",821.3,846.6,842.5,872.8,862.6,1042.5,0.9037042370135715,-0.1460774080990753,0.2044058523256903,0.6895066741128208,0.4403190022541911,0.3562325718739656,3393]
["Q9Y4W2","Ribosomal biogenesis protein LAS1L [OS=Homo sapiens]",42,26,58,26,734,83,4.73,167.39,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","LAS1L","ENSG00000001497","","Major pathway of rRNA processing in the nucleolus and cytosol","",5765.2,5873.2,5696.7,5615.1,6194.5,5392.5,1.007731614163387,0.011111461782616433,0.8649269333840834,0.06302057897264207,0.9117033395016247,0.04014645440904698,6934]
["Q9Y4W6","AFG3-like protein 2 [OS=Homo sapiens]",41,33,106,33,797,88.5,8.66,305.32,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;mitochondrion","other molecular function","AFG3L2","ENSG00000141385","Spinocerebellar ataxia","Processing of SMDT1","Ciliary landscape",13714.5,13910.5,14002.1,11146.1,11958.6,9982.4,1.2581066337031652,0.3312542063150059,0.007983791878572453,2.0977907927584645,0.09351528019308664,1.0291174205569156,624]
["Q9Y4X4-1","Krueppel-like factor 12 [OS=Homo sapiens]",4,2,2,1,402,44.2,9.7,3.52,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","KLF12","ENSCANG00000041690; ENSG00000118922; ENSGGOG00000004142; ENSMFAG00000002684; ENSMLEG00000030485; ENSMMUG00000019097; ENSMNEG00000039444; ENSNLEG00000016131; ENSPANG00000007736; ENSPPAG00000031325; ENSRBIG00000037086; ENSRROG00000027231","","","",31.7,44.7,37,44.3,53.6,6.6,1.0851674641148326,0.11791769797398376,0.8514703164166216,0.06983048762054538,0.9040378475724996,0.043813387392095074,6884]
["Q9Y4X5","E3 ubiquitin-protein ligase ARIH1 [OS=Homo sapiens]",38,15,49,15,557,64.1,5.08,160.36,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","ARIH1","ENSG00000166233","","ISG15 antiviral mechanism","",5280.9,5172.9,5329.6,5067.9,5179.7,4156.1,1.095787887834376,0.13196856218064587,0.2328818105305087,0.6328644311506924,0.46215942252714853,0.33520818812163233,3683]
["Q9Y4Y9","U6 snRNA-associated Sm-like protein LSm5 [OS=Homo sapiens]",25,1,2,1,91,9.9,4.54,4.63,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LSM5","ENSG00000106355","RNA degradation; Spliceosome","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease","",14.7,15.6,16.6,19,16.5,4.1,1.1843434343434343,0.2440874924357668,0.6276615533208751,0.20227447273843088,0.7405291837324094,0.1304578215665402,6195]
["Q9Y4Z0","U6 snRNA-associated Sm-like protein LSm4 [OS=Homo sapiens]",12,2,4,2,139,15.3,9.99,6.58,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LSM4","ENSG00000130520","RNA degradation; Spliceosome","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease","Ciliary landscape",438.1,424,415,525.8,525.5,843.3,0.674073683099335,-0.5690217936407049,0.12436924234279559,0.90528701138497,0.34989022027848077,0.45606819623800604,2598]
["Q9Y508-1","E3 ubiquitin-protein ligase RNF114 [OS=Homo sapiens]",18,4,6,4,228,25.7,7.25,19.78,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus","other molecular function","RNF114","ENSG00000124226; ENSPPAG00000043607; ENSPTRG00000013613","","Antigen processing: Ubiquitination & Proteasome degradation","",936.7,975.4,969.1,879,1014.2,967.6,1.0071308724832215,0.010251167768254934,0.8775705458311919,0.056717961547346284,0.9197251390135046,0.03634194270333107,6974]
["Q9Y512","sorting and assembly machinery component 50 homolog [OS=Homo sapiens]",42,16,73,16,469,51.9,6.9,220.8,"cell organization and biogenesis;transport","other membranes;mitochondrion","","SAMM50","ENSG00000100347","","RAC2 GTPase cycle; Mitochondrial protein import; Cristae formation","",7250.1,7611.1,7685.6,6283.9,6496.4,4590.5,1.2979713081723354,0.37625849272458045,0.049181807419327046,1.3081955150886264,0.2194565509327603,0.6586514506290532,1638]
["Q9Y519","Transmembrane protein 184B [OS=Homo sapiens]",2,1,1,1,407,45.5,6.89,2.07,"","other membranes","","TMEM184B","ENSG00000198792","","","",52,50.6,62.8,46.4,60.4,34.5,1.170559094125973,0.2271977688373351,0.3940257179620004,0.4044754309549584,0.5784161423145734,0.23775959534644497,4979]
["Q9Y520-7","Isoform 7 of Protein PRRC2C [OS=Homo sapiens]",23,56,122,54,2898,316.9,9.13,331.37,"","","","PRRC2C","","","","",14442.7,13514.2,12892.5,20416.6,21211.3,19705.6,0.6660210162472386,-0.5863603927300277,4.0139721678572387E-4,3.396425643155939,0.02205873877809666,1.6564193222390518,133]
["Q9Y535","DNA-directed RNA polymerase III subunit RPC8 [OS=Homo sapiens]",27,3,6,3,204,22.9,4.58,24.95,"RNA metabolism OR transcription;other metabolic processes;stress response","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","POLR3H","ENSG00000100413","RNA polymerase; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway",431.7,422.9,438.4,428.3,476.3,650.8,0.8312974154558312,-0.26656336874907954,0.26626111540880665,0.5746922529994208,0.49330861660911735,0.3068812986608869,3945]
["Q9Y547","Intraflagellar transport protein 25 homolog [OS=Homo sapiens]",42,4,11,4,144,16.3,5.03,43.54,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","other molecular function","HSPB11","ENSG00000081870","","Intraflagellar transport","Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); GDNF/RET signaling axis",669.1,660.1,629.2,737.8,630.3,562.4,1.0144522144522146,0.020700908863431622,0.8679348424033575,0.06151287695118938,0.9128990880883782,0.03957722674666729,6949]
["Q9Y548","Protein YIPF1 [OS=Homo sapiens]",8,3,3,3,306,34.3,5.31,9.76,"transport","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle","other molecular function","YIPF1","ENSG00000058799","","","",431.3,435.8,425,407.1,437.9,248.1,1.182051047479645,0.24129234038472797,0.3230207008430092,0.49076964493263653,0.5373141334687197,0.26977173563315504,4394]
["Q9Y570","Protein phosphatase methylesterase 1 [OS=Homo sapiens]",38,11,21,11,386,42.3,5.97,56.27,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","nucleus","enzyme regulator activity;other molecular function","PPME1","ENSG00000214517","","Cyclin A/B1/B2 associated events during G2/M transition","",2348.8,2398.3,2496.7,2407.3,2241.3,2353.2,1.03456254106087,0.049020861197058424,0.2849994251386353,0.5451560159892804,0.5098044048796587,0.2925964164017362,4086]
["Q9Y572-1","Receptor-interacting serine/threonine-protein kinase 3 [OS=Homo sapiens]",7,3,3,3,518,56.9,6.47,9.74,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","RIPK3","ENSG00000129465; ENSG00000285379","Necroptosis; NOD-like receptor signaling pathway; Cytosolic DNA-sensing pathway; TNF signaling pathway; Salmonella infection","Regulation of necroptotic cell death; IKK complex recruitment mediated by RIP1; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; TRIF-mediated programmed cell death; TLR3-mediated TICAM1-dependent programmed cell death; TRP channels; Microbial modulation of RIPK1-mediated regulated necrosis","TNF-alpha signaling pathway; Nanoparticle triggered regulated necrosis; Cytosolic DNA-sensing pathway",144.2,160.1,156.7,165.4,163.6,189.6,0.8889317392981102,-0.16985545553659448,0.11823977592581884,0.9272364019725294,0.3422631771254693,0.46563982254323666,2525]
["Q9Y575","Ankyrin repeat and SOCS box protein 3 [OS=Homo sapiens]",2,1,1,1,518,57.7,6.27,2.27,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol","","ASB3","ENSG00000115239","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",66.5,73.8,81,155.4,146.1,289.7,0.37432341001353175,-1.4176428183451395,0.057166780422333204,1.242856266141297,0.23646406231286554,0.6262348537640879,1767]
["Q9Y580","RNA-binding protein 7 [OS=Homo sapiens]",6,2,5,2,266,30.5,9.57,13.63,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","RBM7","ENSG00000076053","","","",480.4,452.2,432.3,584.2,643.4,620,0.7387421519809482,-0.4368571959705362,1.9104940738999402E-3,2.7188543050975547,0.04701616560988102,1.327752792530794,297]
["Q9Y587-1","AP-4 complex subunit sigma-1 [OS=Homo sapiens]",7,1,1,1,144,17,5.19,2.06,"transport;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","AP4S1","ENSCANG00000008358; ENSCATG00000035780; ENSG00000100478; ENSGGOG00000003198; ENSMMUG00000003123; ENSPANG00000017427; ENSPCOG00000016646; ENSPPAG00000041450; ENSPTRG00000006239; ENSRROG00000019504","Lysosome","Lysosome Vesicle Biogenesis","",27.5,37.3,29.5,30.7,30,18.3,1.1936708860759495,0.2554051176106315,0.36636126572446265,0.4360904492273563,0.5626674703047063,0.24974819214214083,4759]
["Q9Y592","Centrosomal protein of 83 kDa [OS=Homo sapiens]",2,2,2,2,693,82,6.28,4.99,"","","","","","","","",48.8,58.3,60.8,76.9,55.6,32.7,1.0163438256658595,0.023388543517584584,0.9492026026617697,0.022641079641281845,0.9696326796442871,0.013392755853104071,7155]
["Q9Y597","BTB/POZ domain-containing protein KCTD3 [OS=Homo sapiens]",1,1,1,1,815,88.9,7.03,3.19,"cell organization and biogenesis","plasma membrane;other membranes","","KCTD3","ENSG00000136636","","CDC42 GTPase cycle","",116.4,99.1,99,203.7,200.9,316.9,0.4358974358974359,-1.197939377611909,0.024656314131676575,1.6080718454984388,0.15522222221225157,0.8090461033530397,1161]
["Q9Y5A7","NEDD8 ultimate buster 1 [OS=Homo sapiens]",25,15,24,15,615,70.5,5.96,68.07,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus","","NUB1","ENSG00000013374","","","",3137.1,3264.4,3259.4,3527.5,3518,3302.6,0.9335916738338438,-0.09913640035044279,0.05333315266224743,1.273002743274773,0.22822717377539023,0.6416326477437863,1708]
["Q9Y5A9-1","YTH domain-containing family protein 2 [OS=Homo sapiens]",16,9,24,6,579,62.3,8.79,62.04,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity","YTHDF2","ENSCSAG00000001018; ENSG00000198492; ENSMFAG00000026128; ENSMMUG00000011391; ENSMNEG00000041161; ENSNLEG00000009856; ENSPTRG00000000439; ENSRBIG00000043898; ENSRROG00000038863","","","",1077.9,1101.4,1118.6,1897.1,1811.7,1087.1,0.6876498675952376,-0.540253923655379,0.1241989479694118,0.9058820828471543,0.34981507156394254,0.45616148314765803,2595]
["Q9Y5B0","RNA polymerase II subunit A C-terminal domain phosphatase [OS=Homo sapiens]",12,10,17,10,961,104.3,5.27,44.42,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","CTDP1","ENSG00000060069","","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat","",1244.1,1255,1232.9,1329.1,1355.8,2080.4,0.7831616057750824,-0.3526180558339455,0.23435719295122326,0.6301217124613079,0.4635769210502005,0.3338781933081795,3695]
["Q9Y5B6","PAX3- and PAX7-binding protein 1 [OS=Homo sapiens]",14,11,23,11,917,104.7,5.68,71.3,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus","nucleic acid binding activity","PAXBP1","ENSG00000159086; ENSG00000263141","","","",2487.6,2581.6,2518,2689.1,2771.9,1931.6,1.0263236209182154,0.03748571406063959,0.8211738160823658,0.08556490697830559,0.8823815674428127,0.054343572691035937,6802]
["Q9Y5B8","Nucleoside diphosphate kinase 7 [OS=Homo sapiens]",11,4,5,4,376,42.5,6.47,11.96,"other metabolic processes","cytosol;cytoskeleton","kinase activity;other molecular function","NME7","ENSG00000143156","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors","Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes","Pyrimidine metabolism; Ciliopathies",414.3,410.9,428.1,407.5,395.5,324.7,1.1113771393101002,0.15234846990783074,0.18746520679432654,0.7270793247329852,0.4210765815795122,0.37563891144985223,3254]
["Q9Y5B9","FACT complex subunit SPT16 [OS=Homo sapiens]",41,44,216,44,1047,119.8,5.66,598.2,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus","other molecular function","SUPT16H","ENSG00000092201","","Regulation of TP53 Activity through Phosphorylation; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes","",29384.3,30106.7,30045.5,26839.8,27284.2,20747.8,1.195864130420265,0.25805348526853966,0.08254103639196542,1.0833300823875354,0.28578514210747286,0.5439603538112188,2111]
["Q9Y5J1","U3 small nucleolar RNA-associated protein 18 homolog [OS=Homo sapiens]",23,8,18,8,556,62,8.76,49.37,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","","UTP18","ENSG00000011260","Ribosome biogenesis in eukaryotes","rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol","",905,897.4,860.1,1495.9,1639.9,1342.2,0.5945734702992407,-0.7500730028520347,2.2510226461275712E-3,2.6476201358129994,0.050314142264667946,1.2983099265893123,327]
["Q9Y5J6","Mitochondrial import inner membrane translocase subunit Tim10 B [OS=Homo sapiens]",24,1,1,1,103,11.6,7.43,2.04,"cell adhesion;cell organization and biogenesis;transport","other membranes;mitochondrion","transporter activity;other molecular function","TIMM10B","ENSG00000132286","","Mitochondrial protein import","",50.7,52.7,61,47.6,58.8,23,1.2704791344667699,0.3453726816891755,0.349958508488887,0.4559834430854074,0.5512600729623438,0.2586434617563153,4640]
["Q9Y5J9","mitochondrial import inner membrane translocase subunit Tim8 B [OS=Homo sapiens]",13,1,2,1,83,9.3,5.12,3.6,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","TIMM8B","ENSG00000150779","","Mitochondrial protein import","",175.7,182.5,164.8,156.4,221.5,417.9,0.6572003015833124,-0.6055949525594337,0.31257897305597604,0.5050402399857424,0.5306944748121089,0.2751554338914431,4305]
["Q9Y5K5-1","Ubiquitin carboxyl-terminal hydrolase isozyme L5 [OS=Homo sapiens]",61,15,80,1,329,37.6,5.33,271.77,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","UCHL5","ENSCANG00000036448; ENSCATG00000035323; ENSG00000116750; ENSGGOG00000004347; ENSMFAG00000038349; ENSMLEG00000030039; ENSMNEG00000039813; ENSPPAG00000029294; ENSPTRG00000001793","","UCH proteinases; Downregulation of TGF-beta receptor signaling","TGF-beta signaling pathway",186.8,153.5,162.2,204.5,189.6,173.9,0.8846830985915493,-0.17676733343839118,0.1765803530311618,0.7530576192455242,0.4098525882199941,0.3873723179980952,3149]
["Q9Y5K5-3","Isoform 3 of Ubiquitin carboxyl-terminal hydrolase isozyme L5 [OS=Homo sapiens]",61,15,82,1,328,37.5,5.4,278.15,"","","","UCHL5","","","","",8262.9,8754.6,8955.4,8897.7,8331.1,9127.4,0.9854569323347067,-0.021135272695049286,0.7045091717800156,0.15211334857659561,0.7983345017891681,0.0978151013278904,6450]
["Q9Y5K6","CD2-associated protein [OS=Homo sapiens]",41,23,57,23,639,71.4,6.4,150.5,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","CD2AP","ENSG00000198087","Bacterial invasion of epithelial cells","Nephrin family interactions","Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome; Genes controlling nephrogenesis",6977.3,6959.1,6853.3,7636.1,8096.1,4549.7,1.0250371020466524,0.03567613018923374,0.8865946398532188,0.05227489867305489,0.9261283725435439,0.033328810701222546,6997]
["Q9Y5K8","V-type proton ATPase subunit D [OS=Homo sapiens]",39,11,36,11,247,28.2,9.36,101.86,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol","transporter activity","ATP6V1D","ENSG00000100554","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis","Neutrophil degranulation; Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Proximal tubule transport",3843.6,3908.2,4072.2,3850.9,3964.1,3413.4,1.053044066830537,0.0745658102170491,0.3347028943883137,0.47534053200601734,0.5437527128437841,0.2645985632876112,4499]
["Q9Y5L0-2","transportin-3 [OS=Homo sapiens]",31,23,71,23,923,104.1,5.57,225.81,"transport","other membranes;nucleus;other cell component","other molecular function","TNPO3","ENSCANG00000033070; ENSCATG00000030018; ENSG00000064419; ENSGGOG00000008339; ENSMLEG00000037881; ENSMMUG00000004311; ENSMNEG00000045277; ENSPPAG00000034975; ENSPPYG00000017990; ENSPTRG00000019676","Nucleocytoplasmic transport","","",7218,7045.4,7050.7,7307.7,7200.5,6476.4,1.0157019909838645,0.022477174555338812,0.7020538278827321,0.15362958835989066,0.7966637832626748,0.09872492563182882,6441]
["Q9Y5M8","signal recognition particle receptor subunit beta [OS=Homo sapiens]",50,11,82,11,271,29.7,9.04,282.32,"transport","other membranes;cytoskeleton;ER/Golgi;other cell component","other molecular function","SRPRB","ENSG00000144867","Protein export","XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane","",9271,9533.3,9516,8627.2,9191.7,9045.2,1.0542061710610071,0.07615704238313172,0.06222370487460687,1.206044134039018,0.2467678019145424,0.6077115073741189,1843]
["Q9Y5N5","HemK methyltransferase family member 2 [OS=Homo sapiens]",24,5,9,5,214,22.9,5.11,21.42,"protein metabolism;DNA metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","N6AMT1","ENSG00000156239","","Eukaryotic Translation Termination; Methylation","",788,753.1,778.1,792.9,870.4,1349,0.7699100355210303,-0.37723821906744537,0.2554257716843496,0.5927352858680665,0.48453334161456296,0.31467633299709447,3853]
["Q9Y5N6","Origin recognition complex subunit 6 [OS=Homo sapiens]",7,1,1,1,252,28.1,8.66,2.55,"DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","ORC6","ENSG00000091651","Cell cycle","Assembly of the ORC complex at the origin of replication; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation","Cell cycle; G1 to S cell cycle control; DNA replication",65.7,67.9,62.6,95.5,93.2,97.6,0.6852951449528468,-0.5452026287801138,1.13333088790767E-4,3.945643274768011,0.012942992905808063,1.887965286867925,64]
["Q9Y5P4-1","Collagen type IV alpha-3-binding protein [OS=Homo sapiens]",24,14,34,14,624,70.8,5.48,79.24,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus","transporter activity;kinase activity;other molecular function","CERT1","ENSG00000113163; ENSPTRG00000016996","","","Sphingolipid pathway",3155.1,3123.5,3111.8,3195.8,3106.1,2711.5,1.0418266137084786,0.05911519665971614,0.4473757610603748,0.34932754979436165,0.6098227224151958,0.21479639755724944,5362]
["Q9Y5P6","Mannose-1-phosphate guanyltransferase beta [OS=Homo sapiens]",45,11,38,11,360,39.8,6.61,132.58,"other metabolic processes","other cell component","other molecular function","GMPPB","ENSG00000173540","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars","Synthesis of GDP-mannose","",4133,4134.8,4072.7,4114.9,3863.4,3937.3,1.0356591359226561,0.05054925029134417,0.1411308316512544,0.8503780992626626,0.3687970141362239,0.4332126037502169,2797]
["Q9Y5Q8-1","general transcription factor 3C polypeptide 5 [OS=Homo sapiens]",23,10,18,10,519,59.5,6.9,39.12,"RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","nucleic acid binding activity","GTF3C5","ENSG00000148308","","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter","",1235.4,1289.8,1248.4,1287.4,1269,1408.4,0.9517756255044388,-0.07130658661100496,0.2440545078725873,0.6125131661836158,0.4739092449630023,0.32430481905486214,3764]
["Q9Y5Q9","General transcription factor 3C polypeptide 3 [OS=Homo sapiens]",23,14,28,14,886,101.2,5.07,89.01,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","nucleic acid binding activity","GTF3C3","ENSG00000119041","","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter","",1481.3,1550.1,1567.4,1570.2,1521.3,1454.1,1.0117036254839844,0.01678672020314921,0.6992876600608542,0.15534413544453549,0.7952533853095975,0.09949447347096249,6427]
["Q9Y5R8","trafficking protein particle complex subunit 1 [OS=Homo sapiens]",4,1,1,1,145,16.8,9.16,1.79,"transport","non-structural extracellular;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","TRAPPC1","ENSG00000170043","","Neutrophil degranulation; COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs","",72.7,72.6,84.2,68.9,89.6,53.9,1.0805084745762712,0.1117103874970167,0.6329420537535564,0.19863604809798743,0.7442364013649845,0.12828909200687233,6216]
["Q9Y5S1","Transient receptor potential cation channel subfamily V member 2 [OS=Homo sapiens]",17,7,12,7,764,85.9,5.83,30.85,"cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","transporter activity","TRPV2","ENSG00000187688","NOD-like receptor signaling pathway; Inflammatory mediator regulation of TRP channels","TRP channels","",1017.3,918.9,952.7,936.5,977.1,2221.9,0.6985612380606939,-0.5175415025540706,0.3813933221933518,0.4186269152752454,0.5700621251352164,0.24407781251489274,4890]
["Q9Y5S2","Serine/threonine-protein kinase MRCK beta [OS=Homo sapiens]",3,4,5,4,1711,194.2,6.37,8.61,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","kinase activity;other molecular function","CDC42BPB","ENSG00000198752","","CDC42 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle","VEGFA-VEGFR2 signaling pathway",709.4,1063.3,1180.3,769.1,636.6,212.7,1.824641621354424,0.8676131314630336,0.11267117048372088,0.9481871939940764,0.33354134672560387,0.47685032204203565,2469]
["Q9Y5S9","RNA-binding protein 8A [OS=Homo sapiens]",47,7,39,1,174,19.9,5.72,112.15,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","RBM8A","ENSG00000265241","Nucleocytoplasmic transport; mRNA surveillance pathway; Spliceosome","Regulation of expression of SLITs and ROBOs; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); RNA Polymerase II Transcription Termination; mRNA 3'-end processing; Transport of Mature mRNA derived from an Intron-Containing Transcript","",1427.7,1537.6,1334.2,1846.1,1465,3052.4,0.6756501925041252,-0.5656515882592447,0.22666953011174182,0.6446068556728064,0.4576595567919119,0.33945746432199914,3620]
["Q9Y5S9-2","Isoform 2 of RNA-binding protein 8A [OS=Homo sapiens]",47,7,32,1,173,19.7,5.92,94.61,"","","","RBM8A","","","","",2790.5,2988,2501.6,3466.6,2847,2293.7,0.961985756276649,-0.05591256211987716,0.78113696809329,0.10727280828445619,0.8525205464825828,0.06929514533666273,6697]
["Q9Y5T5-2","Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 16 [OS=Homo sapiens]",23,13,22,13,822,93.4,6.93,70.14,"","","","USP16","","","","",1591.5,1622.8,1681.6,1776.4,1733.1,2003,0.8881451247165532,-0.1711326597510009,0.07919881042033122,1.101281341538863,0.278836274259249,0.5546507288313103,2076]
["Q9Y5U2-1","Protein TSSC4 [OS=Homo sapiens]",13,4,9,4,329,34.3,5.19,23.79,"","","","TSSC4","ENSG00000184281","","","",702.7,722.3,713.6,775.7,803,1294,0.7444564347129878,-0.4257406695353415,0.22007541896337526,0.657428462693046,0.4543873551421779,0.34257376283486085,3540]
["Q9Y5U8","Mitochondrial pyruvate carrier 1 [OS=Homo sapiens]",27,2,4,2,109,12.3,9.61,11.35,"transport","other membranes;mitochondrion","transporter activity","MPC1","ENSG00000060762","Diabetic cardiomyopathy","Pyruvate metabolism","Glycolysis and gluconeogenesis",357.9,381,408.5,385.6,313,619.3,0.8706275134683967,-0.1998724821619489,0.5763390242758402,0.23932197307201208,0.7044250716441666,0.1521651951764499,5980]
["Q9Y5U9","immediate early response 3-interacting protein 1 [OS=Homo sapiens]",24,1,9,1,82,9,8.22,48,"transport;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","","IER3IP1","ENSG00000134049","","","",1046.6,1100.1,1061.8,762.7,929.2,355.5,{"$f":"AVERAGE(S7234:U7234)/AVERAGE(V7234:X7234)","v":1.5671095047377162},{"$f":"LOG(Y7234,2)","v":0.6481059943748104},{"$f":"TTEST(V7234:X7234,S7234:U7234,2,2)","v":0.08654194834227208},1.0627733316381878,{"$f":"AA7234*7309/AE7234","v":0.29284032427484563},0.5333691209051458,2160]
["Q9Y5W8","Sorting nexin-13 [OS=Homo sapiens]",4,3,3,3,968,112.1,6.58,8.65,"transport;other biological processes","other membranes;other cytoplasmic organelle","other molecular function","SNX13","ENSG00000071189","","","",149.2,146,148.8,170.2,173.9,246.2,0.7521599186854142,-0.41088866521009826,0.12023034168380602,{"$f":"-LOG10(AA7235)","v":0.919985918664503},0.34447807423243365,{"$f":"-LOG10(AC7235)","v":0.46283841539031995},2551]
["Q9Y5W9","Sorting nexin-11 [OS=Homo sapiens]",5,1,1,1,270,30.4,7.05,3.13,"cell organization and biogenesis;transport","other membranes;other cytoplasmic organelle","other molecular function","SNX11","ENSG00000002919","","","",65.8,74.5,61.2,62.3,59.7,130.6,0.7977038796516231,-0.3260748003722225,0.5093250809454785,0.2930049371204544,0.6545906482557591,0.18403020348864899,5687]
["Q9Y5X2","Sorting nexin-8 [OS=Homo sapiens]",15,6,8,6,465,52.5,7.39,23.67,"transport","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","SNX8","ENSG00000106266","","","",590.7,639.2,618.7,600.9,604.8,1394.9,0.7108359609320927,-0.49241142625844436,0.39677231798700363,0.4014586353204373,0.5790752540269588,0.2372649936388376,5008]
["Q9Y5X3","sorting nexin-5 [OS=Homo sapiens]",45,16,60,15,404,46.8,6.76,184.77,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","SNX5","ENSG00000089006","Endocytosis","Golgi Associated Vesicle Biogenesis","",7716.3,7984.2,8063.8,8027.7,7461.4,3522,1.2500223553608156,0.3219538962311925,0.327284666151006,0.485074341658095,0.5399827595705876,0.26762010599719155,4430]
["Q9Y5Y0","Feline leukemia virus subgroup C receptor-related protein 1 [OS=Homo sapiens]",2,1,1,1,555,59.8,5.97,3.04,"other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion","transporter activity;other molecular function","FLVCR1","ENSG00000162769","","","",150.6,159.9,187.3,199.4,222.3,293.4,0.6961264158858901,-0.5225787729934112,0.07556127074416273,1.1217007469844922,0.27205779697984506,0.5653388230137321,2030]
["Q9Y5Y2","Cytosolic Fe-S cluster assembly factor NUBP2 [OS=Homo sapiens]",42,8,17,8,271,28.8,5.83,54.52,"cell organization and biogenesis;other metabolic processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","NUBP2","ENSG00000095906","","Cytosolic iron-sulfur cluster assembly","",1890.8,2051.9,2097.2,1820.8,1755.8,2313.3,1.0254673254214843,0.03628152379886245,0.8022065352036887,0.09571380434472439,0.8692850357010764,0.06083779646867449,6745]
["Q9Y5Y5","Peroxisomal membrane protein PEX16 [OS=Homo sapiens]",15,3,8,3,336,38.6,9.85,31.89,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","other molecular function","PEX16","ENSG00000121680","Peroxisome","Class I peroxisomal membrane protein import","",687.1,609.2,598.2,905.4,593.5,1253.7,0.6882583739010391,-0.5389778369796996,0.21192587944498298,0.6738160059419839,0.44754875841184066,0.34915964335213867,3461]
["Q9Y5Y6","suppressor of tumorigenicity 14 protein [OS=Homo sapiens]",20,16,31,16,855,94.7,6.55,89.97,"protein metabolism;developmental processes","non-structural extracellular;plasma membrane;other membranes","other molecular function","ST14","ENSG00000149418","MicroRNAs in cancer","Formation of the cornified envelope","",3319.3,3256.8,3323,3261.2,3742.2,4199.6,0.8836115326251898,-0.17851584646059407,0.1850099522710551,0.7328049088934905,0.4185198827450145,0.3782839050271615,3231]
["Q9Y5Z7","host cell factor 2 [OS=Homo sapiens]",11,7,15,6,792,86.7,8.48,42.05,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","HCFC2","ENSG00000111727","Herpes simplex virus 1 infection","","",912.7,889.4,970.7,1041.4,1061.4,1913.2,0.6904382470119522,-0.5344157096779646,0.22402918986371942,0.649695391617485,0.4559814393522488,0.3410528348595851,3591]
["Q9Y5Z9-1","UbiA prenyltransferase domain-containing protein 1 [OS=Homo sapiens]",8,2,3,2,338,36.8,8.15,6.32,"other metabolic processes;other biological processes","other membranes;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","UBIAD1","ENSG00000120942; ENSGGOG00000001270","","Metabolism of vitamin K","7q11.23 copy number variation syndrome",125.9,104.8,110.7,118.8,131.8,200.7,0.7564812763128739,-0.4026237201847493,0.23426374376097903,0.6302949205492098,0.46364302820173187,0.3338162663162156,3693]
["Q9Y606","tRNA pseudouridine synthase A [OS=Homo sapiens]",36,15,26,15,427,47.4,8.41,75.22,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","PUS1","ENSG00000177192","","","",2373.3,2436.7,2395.7,2236.3,2178.9,2185.3,1.0916900234830693,0.1265632728627208,1.4802884446313207E-3,2.8296536510198655,0.04193576837910978,1.3774153950991228,258]
["Q9Y608","Leucine-rich repeat flightless-interacting protein 2 [OS=Homo sapiens]",5,3,11,2,721,82.1,6.95,36.04,"cell-cell signaling;signal transduction;other biological processes","","other molecular function","LRRFIP2","ENSG00000093167","","","VEGFA-VEGFR2 signaling pathway; Genotoxicity pathway",423.6,413.6,419.1,429.2,512.2,243.6,1.0601687763713081,0.0842939567235067,0.7797423069059092,0.1080489013862007,0.8517615485241803,0.0696819693816586,6691]
["Q9Y613","FH1/FH2 domain-containing protein 1 [OS=Homo sapiens]",38,33,92,33,1164,126.5,6.39,245.41,"cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","FHOD1","ENSG00000135723","Salmonella infection","","VEGFA-VEGFR2 signaling pathway",6123.5,6365.6,6149.6,6514.9,6516.3,8005.6,0.8860045254031031,-0.174614027303523,0.18690829602090603,0.7283714218092824,0.4204717561147437,0.3762631712702922,3249]
["Q9Y617-1","phosphoserine aminotransferase [OS=Homo sapiens]",65,21,89,20,370,40.4,7.66,269.38,"other metabolic processes","cytosol;other cell component","other molecular function","PSAT1","ENSG00000135069; ENSGGOG00000015480; ENSPPAG00000036829; ENSPTRG00000021045","Glycine, serine and threonine metabolism; Cysteine and methionine metabolism; Vitamin B6 metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; Biosynthesis of cofactors","Serine biosynthesis","Trans-sulfuration and one-carbon metabolism; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Male infertility; Neuroinflammation and glutamatergic signaling",11206.9,11633.4,11849.2,15848.9,15281.6,15400.3,0.7455169479140697,-0.42368694506991245,1.030033753284752E-4,3.987148543619942,0.01298020121165216,1.8867185752989064,58]
["Q9Y619","mitochondrial ornithine transporter 1 [OS=Homo sapiens]",5,2,2,2,301,32.7,9.13,2.12,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","SLC25A15","ENSG00000102743","","Urea cycle","",61.2,75.2,59.2,55,55.8,200.5,0.6283327979441053,-0.6703992065169458,0.4721140766326966,0.3259530503783959,0.6271686270644092,0.20261567454808763,5502]
["Q9Y624","Junctional adhesion molecule A [OS=Homo sapiens]",51,12,52,12,299,32.6,7.9,148.06,"cell adhesion;cell organization and biogenesis;stress response;transport;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","F11R","ENSG00000158769","Cell adhesion molecules; Tight junction; Leukocyte transendothelial migration; Epithelial cell signaling in Helicobacter pylori infection","Integrin cell surface interactions; Cell surface interactions at the vascular wall; Tight junction interactions; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)","1q21.1 copy number variation syndrome",6931.1,7092.4,7029.5,5188.2,5535.4,5637.2,1.2867952667351232,0.36378253439647845,4.054916819902991E-4,3.3920180502142685,0.021953620027163674,1.6584938568253016,135]
["Q9Y639-1","Isoform 1 of Neuroplastin [OS=Homo sapiens]",11,3,5,3,282,31.3,6.87,17.58,"","","","NPTN","","","","",889.5,916.5,896.7,973.3,1006.2,1224.5,0.8435393258426966,-0.2454727662966104,0.10262038215082442,0.9887663723966224,0.31714688082045484,0.49873955558647975,2365]
["Q9Y657","Spindlin-1 [OS=Homo sapiens]",37,7,7,5,262,29.6,6.96,20.32,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;signal transduction;other biological processes","other membranes;cytosol;nucleus","other molecular function","SPIN1","ENSG00000106723","","","",370.3,348.7,374.4,406.6,441.5,824.5,0.6537127824943203,-0.613271187431114,0.2233611567037552,0.6509923500026826,0.45589128577150145,0.34113870913061267,3581]
["Q9Y666","Solute carrier family 12 member 7 [OS=Homo sapiens]",8,8,13,7,1083,119,6.71,26.59,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;other cell component","transporter activity;other molecular function","SLC12A7","ENSG00000113504","Collecting duct acid secretion","Cation-coupled Chloride cotransporters","",585,552.8,542.2,513.3,557.1,880.5,0.8611410118406888,-0.2156785966079284,0.48156620395000055,0.3173439992274746,0.6337355752017562,0.1980919127577404,5554]
["Q9Y672","Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase [OS=Homo sapiens]",10,5,17,5,507,58.1,8.46,38.32,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","ALG6","ENSG00000088035","N-Glycan biosynthesis; Metabolic pathways","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG6 causes CDG-1c","GPCRs, other",2013.7,2119.2,2125.7,1533.1,1630.4,1181.4,1.4404474211144098,0.5265170005311703,0.010656685110621464,1.9723778667963454,0.10803011300073827,0.9664551696318013,721]
["Q9Y673","dolichyl-phosphate beta-glucosyltransferase [OS=Homo sapiens]",37,13,32,13,324,36.9,9.28,77.45,"protein metabolism;other metabolic processes;developmental processes","other membranes;ER/Golgi","other molecular function","ALG5","ENSG00000120697","N-Glycan biosynthesis; Metabolic pathways","Synthesis of dolichyl-phosphate-glucose","",3211.6,3371.6,3454.5,2769.5,2689.6,1998.1,1.3460414096443705,0.4287227937295262,0.027984460250043437,1.5530830651263177,0.16575236626221027,0.7805402629395677,1234]
["Q9Y676","28S ribosomal protein S18b, mitochondrial [OS=Homo sapiens]",17,3,6,3,258,29.4,9.38,16.02,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus;other cell component","other molecular function","MRPS18B","ENSG00000203624; ENSG00000204568; ENSG00000223775; ENSG00000226111; ENSG00000227420; ENSG00000229861; ENSG00000233813","Viral carcinogenesis","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",231.3,232.1,235.5,191.5,178.6,205.2,1.2148444289935687,0.28077157647329526,6.125155778350164E-3,2.21288286160546,0.08051935896395927,1.0940996913035443,556]
["Q9Y678","Coatomer subunit gamma-1 [OS=Homo sapiens]",67,46,229,42,874,97.7,5.47,675.39,"transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","COPG1","ENSG00000181789","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport","VEGFA-VEGFR2 signaling pathway",22039.2,22634.7,22950.8,22028.2,21004.3,20110,1.0709854693748266,0.09893890641581796,0.0721007605059616,1.1420601543956792,0.26548335442724097,0.5759627036108402,1985]
["Q9Y679-1","Ancient ubiquitous protein 1 [OS=Homo sapiens]",13,6,16,6,476,53,8.09,46.26,"","","","","","","","",1711.6,1676,1729.4,1504.1,1496.8,2531.5,0.9249150459113586,-0.11260723571349888,0.707923474603858,0.15001368631235878,0.8003422545830777,0.0967242536447987,6465]
["Q9Y689-1","ADP-ribosylation factor-like protein 5A [OS=Homo sapiens]",4,1,1,1,179,20.7,6.79,2.51,"transport;other biological processes","ER/Golgi","other molecular function","ARL5A; LOC111161526","ENSAMEG00000008735; ENSANAG00000027698; ENSCANG00000029546; ENSCATG00000029667; ENSCCAG00000023321; ENSCJAG00000040846; ENSECAG00000023672; ENSFCAG00000014742; ENSG00000162980; ENSGGOG00000002066; ENSLCNG00005010847; ENSMMUG00000010521; ENSMNEG00000035230; ENSMPUG00000000396; ENSNVIG00000004853; ENSOCUG00000035346; ENSOGAG00000011424; ENSPANG00000009772; ENSPPAG00000033494; ENSPTRG00000012538; ENSRBIG00000031831; ENSRFEG00010001991; ENSRROG00000040290; ENSSBOG00000034323; ENSSSCG00000031541; ENSSSCG00070004184; ENSSSUG00005001466","","","",34,34.7,36.3,40.5,34.5,84.8,0.6570713391739674,-0.6058780803744919,0.3140105920866662,0.5030557022223076,0.5323830706475164,0.2737757631922227,4311]
["Q9Y692-1","Glucocorticoid modulatory element-binding protein 1 [OS=Homo sapiens]",8,4,8,4,573,62.6,4.83,26.33,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","GMEB1","ENSG00000162419; ENSGGOG00000009221; ENSPPAG00000038756","","","",286.9,306,340.4,328.5,354.8,419.1,0.8466074020319302,-0.24023499244875354,0.14444571827144173,0.8402953271922048,0.37371814330830716,0.4274558174636891,2825]
["Q9Y696","Chloride intracellular channel protein 4 [OS=Homo sapiens]",74,15,147,13,253,28.8,5.59,511.58,"transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","transporter activity","CLIC4","ENSG00000169504","","","",12177.1,12140.7,13133.7,13157.6,13710.3,10461.1,1.003281630903587,0.004726641319382075,0.9709819934104111,0.012788823887059252,0.9826789517912898,0.007588346093894089,7222]
["Q9Y697","Cysteine desulfurase, mitochondrial [OS=Homo sapiens]",48,15,40,15,457,50.2,8.31,118.05,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytosol;mitochondrion;nucleus","other molecular function","NFS1","ENSG00000244005","Thiamine metabolism; Metabolic pathways; Biosynthesis of cofactors; Sulfur relay system","","",3023.4,3211.1,3018.5,2905,2766.2,3445.4,1.0149617181844108,0.021425313590704567,0.8440391451094357,0.0736374110629848,0.899807775905027,0.04585025809415358,6856]
["Q9Y6A4","Cilia- and flagella-associated protein 20 [OS=Homo sapiens]",38,7,19,7,193,22.8,9.76,47.39,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","","CFAP20","ENSG00000070761","","","",2108.2,2160.6,2115.8,2314.3,1875.6,1614.5,1.0999586520570601,0.1374492932104822,0.39852167414016176,0.3995480539328642,0.580469293800407,0.23622074902748297,5018]
["Q9Y6A5","Transforming acidic coiled-coil-containing protein 3 [OS=Homo sapiens]",32,22,51,22,838,90.3,5.05,162.76,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","","TACC3","ENSG00000013810","","Negative regulation of NOTCH4 signaling; NOTCH3 Activation and Transmission of Signal to the Nucleus","",4300.5,4143.9,4142.9,4256.7,4354.1,6058.6,0.8580650878699878,-0.22084100848453067,0.3028483115710078,0.5187748432568738,0.5235379161004011,0.2810518600082895,4228]
["Q9Y6A9","Signal peptidase complex subunit 1 [OS=Homo sapiens]",17,2,7,2,102,11.8,9.31,25.02,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","translation activity;other molecular function","SPCS1","ENSG00000114902","Protein export","","",1135.3,1054.2,1089.7,926.9,1087.6,853.2,1.143494786762911,0.19344978846192512,0.13372952006371158,0.8737727140121039,0.3600107042893804,0.44368458605299677,2715]
["Q9Y6B6","GTP-binding protein SAR1b [OS=Homo sapiens]",47,8,65,4,198,22.4,6.11,172.63,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","SAR1B","ENSG00000152700","Protein processing in endoplasmic reticulum; Legionellosis","MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Chylomicron assembly","Sterol regulatory element-binding proteins (SREBP) signaling",2084.7,2114.4,2093,1919.2,1980,1847.4,1.0949256951936797,0.13083296771418165,0.00985702350903909,2.006254207650288,0.10396101706719582,0.9831294803781218,693]
["Q9Y6B7","AP-4 complex subunit beta-1 [OS=Homo sapiens]",5,5,8,5,739,83.2,5.86,15.67,"transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","other molecular function","AP4B1","ENSG00000134262","Lysosome","Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis","",532.5,558.2,515.7,516,580.7,489.9,1.0124795159460482,0.017892720301464167,0.8349410063800536,0.07834420895797158,0.8927126705137233,0.04928830112269782,6836]
["Q9Y6C2","EMILIN-1 [OS=Homo sapiens]",4,3,3,3,1016,106.6,5.15,9.3,"","","","","","","","",336.9,319.8,346.9,477.6,481,684.7,0.6107223270248889,-0.7114115061344194,0.0364499708560224,1.4383028145908272,0.18695637683274927,0.7282597170513833,1425]
["Q9Y6C9","Mitochondrial carrier homolog 2 [OS=Homo sapiens]",45,12,36,12,303,33.3,7.97,143.4,"other biological processes","other membranes;mitochondrion","","MTCH2","ENSG00000109919; ENSG00000285121","","","",5587.1,4904.2,4715,5305.7,4488.1,6752.8,0.9189984649414381,-0.12186564319157737,0.5649762471594775,0.24796981048925762,0.6955383847883815,0.15767889753134337,5937]
["Q9Y6D0","selenoprotein K [OS=Homo sapiens]",10,1,2,1,94,10.6,10.86,4.11,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi","other molecular function","SELENOK","ENSG00000113811","","","Selenium micronutrient network",106.5,82.2,105.9,154.8,207.7,57.5,0.7014285714285714,-0.5116318975176358,0.4027403328804697,0.3949748753086328,0.5828968501036342,0.23440829154332124,5050]
["Q9Y6D5","Brefeldin A-inhibited guanine nucleotide-exchange protein 2 [OS=Homo sapiens]",29,43,115,33,1785,201.9,6.33,337.73,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","ARFGEF2","ENSG00000124198","Endocytosis","Association of TriC/CCT with target proteins during biosynthesis","",9677,10284.3,9914.6,9717.7,9331.1,9292.4,1.0541508475293917,0.0760813294141985,0.0833287968225442,1.0792048888704,0.28674678718266267,0.5425014393958585,2124]
["Q9Y6D6","Brefeldin A-inhibited guanine nucleotide-exchange protein 1 [OS=Homo sapiens]",21,30,54,20,1849,208.6,5.85,148.05,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","ARFGEF1","ENSG00000066777","Endocytosis","","",2148,2155.4,2172.4,2356.2,2376,1933.4,0.9715254440710512,-0.04167631466662089,0.6841676854029017,0.1648374422565212,0.7836673895329586,0.10586822499493967,6381]
["Q9Y6D9","mitotic spindle assembly checkpoint protein MAD1 [OS=Homo sapiens]",30,21,46,21,718,83,5.92,141.24,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","MAD1L1","ENSG00000002822","Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection; Viral carcinogenesis","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; Malignant pleural mesothelioma; CCL18 signaling pathway",5056.2,4959.7,5035.7,5338.1,5330,5061.8,0.9568783018328152,-0.06359264405979934,0.07683501652165856,1.1144408110062112,0.27474908794364106,0.5610637405849134,2044]
["Q9Y6E0","Serine/threonine-protein kinase 24 [OS=Homo sapiens]",44,16,82,9,443,49.3,5.69,238.94,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","STK24","ENSG00000102572","","Apoptotic cleavage of cellular proteins","",3819.6,3753,3714.6,4121.6,3869.7,5162.4,0.8581007625230924,-0.2207810286811625,0.19200252598175985,0.7166930576885157,0.42616048053467437,0.3704268265164505,3293]
["Q9Y6E2","Basic leucine zipper and W2 domain-containing protein 2 [OS=Homo sapiens]",43,20,98,16,419,48.1,6.68,245.56,"developmental processes;other biological processes","other cell component","","BZW2","ENSG00000136261","","","",7701.2,8253.1,8249.2,7724.9,7336.2,6070.7,1.1453591270029055,0.19580002584267123,0.1265804208135752,0.8976334648574761,0.35258242977378856,0.45273933367712577,2624]
["Q9Y6G1","Transmembrane protein 14A [OS=Homo sapiens]",6,1,1,1,99,10.7,10.55,0,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion;ER/Golgi","","TMEM14A","ENSG00000096092","","","",45.6,51.8,40.3,46.5,23.5,35.4,1.3064516129032258,0.3856536924977495,0.22069565085201873,0.6562062251962067,0.45412852254431446,0.34282122041879715,3552]
["Q9Y6G5","COMM domain-containing protein 10 [OS=Homo sapiens]",29,4,8,4,202,23,6.54,19.29,"","nucleus;other cell component","","COMMD10","ENSG00000145781","","Neddylation","",288.3,297.7,290.7,284.1,293,230.9,1.0850247524752477,0.11772795498861213,0.3073641045409791,0.5123468528741189,0.5261180890140554,0.2789167660151697,4270]
["Q9Y6G9","Cytoplasmic dynein 1 light intermediate chain 1 [OS=Homo sapiens]",54,23,68,23,523,56.5,6.42,245.49,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","DYNC1LI1","ENSG00000144635","Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection","Neutrophil degranulation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; MHC class II antigen presentation; COPI-mediated anterograde transport; HCMV Early Events; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy","Ciliary landscape; Intraflagellar transport proteins binding to dynein",8892.1,9127.5,9488.1,8953,9569,7860.4,1.042653435623749,0.06025970455730956,0.5172659865679535,0.28628607819541724,0.6603837721965367,0.1802036073233699,5725]
["Q9Y6H1","Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 [OS=Homo sapiens]",15,2,2,2,151,15.5,9.22,5.96,"cell organization and biogenesis;stress response;other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","CHCHD2","ENSG00000106153","","Mitochondrial protein import","",186.3,167.3,157.3,306.1,312.3,373.5,0.5150720838794233,-0.9571537445759242,2.2733857705628155E-3,2.6433268626423176,0.05019992929620429,1.2992968945340633,331]
["Q9Y6H3","Mitochondrial inner membrane protease ATP23 homolog [OS=Homo sapiens]",14,2,2,2,246,28.1,8.03,7.23,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component","kinase activity;other molecular function","ATP23","ENSG00000166896; ENSG00000262145","","","",47.9,48.2,36.8,55.8,46.9,68.5,0.7762850467289718,-0.3653415971249728,0.15540481434234837,0.8085355311597565,0.38792820629379243,0.41124864166213787,2928]
["Q9Y6I3","epsin-1 [OS=Homo sapiens]",20,10,24,9,576,60.3,4.83,78.69,"transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","EPN1","ENSG00000063245","Endocytosis","Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation","VEGFA-VEGFR2 signaling pathway; EGF/EGFR signaling pathway",2640.7,2590.3,2730.6,2795.7,2836.8,2571.1,0.9705007557657614,-0.04319875846661852,0.4310428719924039,0.3654795322899365,0.5997510663225738,0.22202897120907208,5253]
["Q9Y6I4-1","Ubiquitin carboxyl-terminal hydrolase 3 [OS=Homo sapiens]",10,4,6,4,520,58.9,8.18,22.19,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","USP3","ENSG00000140455","","Ub-specific processing proteases","",433.1,449.5,448.2,496.4,427.7,1107.7,0.654985726941628,-0.6104646262447411,0.3405861410946145,0.46777302803692317,0.546988377336967,0.2620219016593432,4551]
["Q9Y6I9","Testis-expressed protein 264 [OS=Homo sapiens]",52,11,32,11,313,34.2,4.86,102.42,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","TEX264","ENSG00000164081","","Platelet degranulation","",2587.7,2701.3,2748.2,2572,3068.2,3293,0.8996999955223212,-0.15248407913964085,0.24300616841185538,0.6143827022320161,0.4730045499127166,0.32513468168823034,3755]
["Q9Y6J0","Calcineurin-binding protein cabin-1 [OS=Homo sapiens]",5,9,12,9,2220,246.2,6.02,36.69,"cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity","CABIN1","ENSG00000099991","","Formation of Senescence-Associated Heterochromatin Foci (SAHF)","",1159.2,1143,1178.2,1293.8,1297.2,1434.8,0.8645238213522777,-0.2100223780142353,0.01871757601126106,1.7277503945453643,0.13818864956192636,0.8595276272589412,990]
["Q9Y6J9","TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L [OS=Homo sapiens]",13,6,8,6,622,67.8,8.97,15.23,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","TAF6L","ENSG00000162227","Basal transcription factors","HATs acetylate histones","",661.3,620.6,595.3,761.6,817,1088.5,0.7038356267106596,-0.5066895526981547,0.06258707376243629,1.2035153532643303,0.24753729552470066,0.6063593582644453,1848]
["Q9Y6K0","Choline/ethanolaminephosphotransferase 1 [OS=Homo sapiens]",1,1,1,1,416,46.5,8.21,1.82,"other metabolic processes","other membranes;ER/Golgi;nucleus","other molecular function","CEPT1","ENSG00000134255","Phosphonate and phosphinate metabolism; Glycerophospholipid metabolism; Ether lipid metabolism; Metabolic pathways","Synthesis of PC; Synthesis of PE","Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways",90.2,93,88.7,73.6,76.1,84,1.1634574240479247,0.21841841724193475,0.019613773221330986,1.7074388504132658,0.14137777956085618,0.84961884352661,1014]
["Q9Y6K1","DNA (cytosine-5)-methyltransferase 3A [OS=Homo sapiens]",2,2,3,2,912,101.8,6.57,4.65,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DNMT3A","ENSG00000119772","Cysteine and methionine metabolism; Metabolic pathways; MicroRNAs in cancer","PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; RMTs methylate histone arginines; SUMOylation of DNA methylation proteins","One-carbon metabolism; Trans-sulfuration and one-carbon metabolism; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; One-carbon metabolism and related pathways; MTHFR deficiency",95.9,91.2,95.7,144.3,93.2,2564.1,0.10094231867504283,-3.308396963624159,0.36126937217037863,0.4421688556509674,0.5600249928299676,0.2517925908403416,4715]
["Q9Y6K5","2'-5'-oligoadenylate synthase 3 [OS=Homo sapiens]",5,6,10,6,1087,121.1,8.4,24.05,"other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","OAS3","ENSG00000111331","NOD-like receptor signaling pathway; Hepatitis C; Measles; Influenza A; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease","Interferon gamma signaling; Interferon alpha/beta signaling; OAS antiviral response","Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction",744.5,740.9,736.4,778.8,717.1,1416.2,0.7629545688678272,-0.3903309424415526,0.3613579915489427,0.4420623362767358,0.5596875524965506,0.25205435173571217,4719]
["Q9Y6K9","NF-kappa-B essential modulator [OS=Homo sapiens]",11,4,4,4,419,48.2,5.71,12.21,"cell organization and biogenesis;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","IKBKG","ENSG00000269335","Antifolate resistance; MAPK signaling pathway; Ras signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; TNF signaling pathway; Adipocytokine signaling pathway; Alcoholic liver disease; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Chagas disease; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Chemical carcinogenesis; Pancreatic cancer; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Primary immunodeficiency; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; TNFR1-induced NFkappaB signaling pathway; activated TAK1 mediates p38 MAPK activation; ER-Phagosome pathway; IKK complex recruitment mediated by RIP1; TICAM1, RIP1-mediated IKK complex recruitment; Regulation of TNFR1 signaling; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Ovarian tumor domain proteases; RIP-mediated NFkB activation via ZBP1; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; SUMOylation of immune response proteins","Nucleotide-binding oligomerization domain (NOD) pathway; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; ATM signaling in development and disease ; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNAs involvement in the immune response in sepsis; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Canonical NF-kB pathway; Cytosolic DNA-sensing pathway; Small cell lung cancer; Hepatitis B infection; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Network map of SARS-CoV-2 signaling pathway; T-cell receptor (TCR) signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway",317.7,298.4,289.7,501.9,591,540.5,0.5545487939267785,-0.8506136883161881,8.6122332931612238E-4,3.06488421426886,0.031316822457569844,1.504222309805376,201]
["Q9Y6M1","Insulin-like growth factor 2 mRNA-binding protein 2 [OS=Homo sapiens]",23,13,35,13,599,66.1,8.46,107.13,"transport;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","IGF2BP2","ENSG00000073792","","Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA","",4170.2,4171.8,4140.8,4302.3,3808.4,3281.5,1.0957321676234617,0.1318952000667281,0.2851776895481039,0.5448844538732982,0.5096243845738611,0.292749799996667,4090]
["Q9Y6M5","zinc transporter 1 [OS=Homo sapiens]",45,15,58,15,507,55.3,6.48,185.42,"stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","SLC30A1","ENSG00000170385","Mineral absorption","Zinc efflux and compartmentalization by the SLC30 family","Zinc homeostasis",5959.7,5808.1,5926.8,4652.4,4872.3,6217.9,1.1239947657947225,0.1686353172496047,0.2561270446524129,0.591544561620652,0.48473137477071104,0.314498869180055,3862]
["Q9Y6M7-7","Isoform 7 of Sodium bicarbonate cotransporter 3 [OS=Homo sapiens]",7,8,12,8,1259,140.7,6.62,35,"","","","SLC4A7","","","","",986.8,1030.5,1054.2,1017.8,1068.7,1082.7,0.9691720307964157,-0.0451753240369655,0.3079647161145976,0.5114990382869526,0.5267760613343304,0.27837396922017615,4273]
["Q9Y6M9","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [OS=Homo sapiens]",11,1,1,1,179,21.8,8.38,3.79,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity","NDUFB9","ENSG00000147684","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial immune response to SARS-CoV-2; Oxidative phosphorylation",21.3,19.2,27.8,23.1,29.9,33.1,0.7932636469221835,-0.33412765910675346,0.20501725747008068,0.6882095803658175,0.44111602438881947,0.35544716535187243,3397]
["Q9Y6N1","Cytochrome c oxidase assembly protein COX11, mitochondrial [OS=Homo sapiens]",12,2,10,2,276,31.4,9.06,13.74,"other metabolic processes;other biological processes","other membranes;mitochondrion;other cell component","other molecular function","COX11","ENSG00000166260","Oxidative phosphorylation; Metabolic pathways; Thermogenesis","Cytoprotection by HMOX1; Respiratory electron transport; TP53 Regulates Metabolic Genes","Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis; Mitochondrial complex IV assembly",207,195.4,215.4,172.4,203.8,268.9,0.9576809796930708,-0.062382945882840796,0.7693858310751185,0.11385581587499374,0.8443605164156218,0.07347208316132182,6660]
["Q9Y6N5","Sulfide:quinone oxidoreductase, mitochondrial [OS=Homo sapiens]",71,29,161,29,450,49.9,9.11,531.19,"other metabolic processes","other membranes;mitochondrion","other molecular function","SQOR","ENSG00000137767","Sulfur metabolism; Metabolic pathways","Sulfide oxidation to sulfate","",20143.8,20270.6,20205.7,17622.6,17755.9,13034,1.2521580170410533,0.32441663576609736,0.05875035988408784,1.2309894687124854,0.2393569567406901,0.6209539455365857,1794]
["Q9Y6N7","Roundabout homolog 1 [OS=Homo sapiens]",4,7,11,6,1651,180.8,6.04,21.23,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","ROBO1","ENSG00000169855","Axon guidance","Regulation of expression of SLITs and ROBOs; Netrin-1 signaling; Regulation of cortical dendrite branching; Regulation of commissural axon pathfinding by SLIT and ROBO; Role of ABL in ROBO-SLIT signaling; Inactivation of CDC42 and RAC1; Activation of RAC1; SLIT2:ROBO1 increases RHOA activity","Development of ureteric collection system",622,623.7,604.9,598.1,611.8,959.3,0.8531255762493086,-0.22916997948928092,0.42021291538823563,0.376530603534914,0.5933802547474138,0.22666690931158504,5176]
["Q9Y6P5-2","Isoform T1 of Sestrin-1 [OS=Homo sapiens]",25,13,29,13,551,63.8,6.3,95.15,"","","","SESN1","","","","",2860.3,2844.8,2760.4,3211.2,2917.4,3065.4,0.9207635414400697,-0.11909738524969363,0.05473039145810279,1.261771445563215,0.23176386510270758,0.6349542750584327,1726]
["Q9Y6Q9-1","Nuclear receptor coactivator 3 [OS=Homo sapiens]",3,3,4,3,1424,155.2,7.47,12.25,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","NCOA3","ENSG00000124151","Endocrine resistance; Estrogen signaling pathway; Thyroid hormone signaling pathway; Pathways in cancer; Breast cancer","PPARA activates gene expression; Estrogen-dependent gene expression; Transcriptional regulation of white adipocyte differentiation; MAPK6/MAPK4 signaling; Activation of anterior HOX genes in hindbrain development during early embryogenesis","Androgen receptor signaling pathway; Integrated breast cancer pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Breast cancer pathway; EGF/EGFR signaling pathway",263.6,246.9,217.9,425.3,437.5,519.3,{"$f":"AVERAGE(S7298:U7298)/AVERAGE(V7298:X7298)","v":0.5270240937703494},{"$f":"LOG(Y7298,2)","v":-0.924059176348529},{"$f":"TTEST(V7298:X7298,S7298:U7298,2,2)","v":0.002543160556585471},2.5946262207767203,{"$f":"AA7298*7309/AE7298","v":0.05341367962092875},1.2723475028393285,348]
["Q9Y6R4-1","Mitogen-activated protein kinase kinase kinase 4 [OS=Homo sapiens]",4,5,7,4,1608,181.6,6.32,20.22,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","other cell component","kinase activity;other molecular function","MAP3K4","ENSG00000085511","MAPK signaling pathway; GnRH signaling pathway","","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; EGF/EGFR signaling pathway; Insulin signaling; MAP3K1 role in promoting and blocking gonadal determination; Host-pathogen interaction of human coronaviruses - MAPK signaling; Malignant pleural mesothelioma; G13 signaling pathway; DNA damage response (only ATM dependent)",132.7,132,138.6,122.4,128,303.8,0.7277156261277515,-0.45855330507554115,0.4461527482867982,{"$f":"-LOG10(AA7299)","v":0.350516427429492},0.6094058002669049,{"$f":"-LOG10(AC7299)","v":0.2150934165197738},5351]
["Q9Y6R9","Coiled-coil domain-containing protein 61 [OS=Homo sapiens]",8,5,8,5,512,57.3,10.27,17.7,"cell cycle OR cell proliferation;cell organization and biogenesis","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","CCDC61","ENSG00000104983","","","",392.2,378.8,392.5,539.6,528.9,625.7,0.6867548105300436,-0.5421329838657634,0.004646525699523651,2.3328716564629093,0.07149780281645972,1.1457073042038026,475]
["Q9Y6V0-1","Protein piccolo [OS=Homo sapiens]",0,1,6,1,5065,552.9,6.51,12.09,"","","","","","","","",664.4,691.5,661,503.2,483.7,692.5,1.2009646302250803,0.2641936626586344,0.16983842889337605,0.7699640363061014,0.4012117248809585,0.39662638378547715,3094]
["Q9Y6V7","Probable ATP-dependent RNA helicase ddx49 [OS=Homo sapiens]",10,3,4,3,483,54.2,9.06,15.77,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","DDX49","ENSG00000105671","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",320.5,299.7,296.6,690.1,672.8,426,0.512493711219185,-0.9643937933884215,0.02740313289470575,1.5621997831247174,0.16390302645450439,0.7854130271472799,1222]
["Q9Y6W3","Calpain-7 [OS=Homo sapiens]",18,12,25,12,813,92.6,7.65,63.85,"protein metabolism;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","CAPN7","ENSG00000131375","","Degradation of the extracellular matrix","Integrin-mediated cell adhesion",2922.7,2843.7,2807.9,3159.8,3240.7,2513.4,0.9619021976912463,-0.056037880807601435,0.6519850659204536,0.18576235191013354,0.7578496893785934,0.12041692305751203,6288]
["Q9Y6W5","Wiskott-Aldrich syndrome protein family member 2 [OS=Homo sapiens]",24,13,44,12,498,54.3,5.53,115.77,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","WASF2","ENSG00000158195","Adherens junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Yersinia infection; Choline metabolism in cancer","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RAC2 GTPase cycle; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway","Regulation of actin cytoskeleton",5603.1,5464.8,5576.4,5647.1,5771.9,5427.9,0.9879740486380284,-0.01745494821196209,0.5694290626340597,0.24456037101501957,0.6993710332368244,0.15529235939584113,5951]
["Q9Y6X3-1","MAU2 chromatid cohesion factor homolog [OS=Homo sapiens]",7,3,4,3,613,69,7.25,16.13,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MAU2","ENSANAG00000026794; ENSCANG00000033671; ENSCATG00000015302; ENSCCAG00000031923; ENSCSAG00000005122; ENSG00000129933; ENSGGOG00000002989; ENSMFAG00000041829; ENSMNEG00000034232; ENSPPAG00000032359; ENSPTRG00000010738; ENSRBIG00000036077; ENSRROG00000032649; ENSSBOG00000034577","","Cohesin Loading onto Chromatin","Cohesin complex - Cornelia de Lange syndrome",421.9,437.2,460.5,333.8,303.7,285.3,1.4299956653662766,0.5160107738819482,0.001845351075849955,2.7339209976351118,0.04634938492572963,1.3339560247370459,291]
["Q9Y6X4-1","Soluble lamin-associated protein of 75 kDa [OS=Homo sapiens]",6,4,6,4,670,74.9,4.6,19.28,"","other membranes;nucleus","","FAM169A","ENSG00000198780","","RHOF GTPase cycle","",451.6,472.6,478.7,482.1,513.4,352,1.041113172541744,0.05812690301795143,0.7310749182729259,0.13603811562032786,0.8167879207668627,0.08789069352531771,6542]
["Q9Y6X5","Bis(5'-adenosyl)-triphosphatase ENPP4 [OS=Homo sapiens]",11,5,11,5,453,51.6,6.15,29.68,"other metabolic processes;stress response;other biological processes","plasma membrane;other membranes","other molecular function","ENPP4","ENSG00000001561","Purine metabolism; Metabolic pathways","Neutrophil degranulation","",882.2,901.8,956.8,854.5,909,930,1.0175607945052905,0.025114991357541045,0.645006076826226,0.19043619370633638,0.7532112822372402,0.1230831833756596,6259]
["Q9Y6X9-1","MORC family CW-type zinc finger protein 2 [OS=Homo sapiens]",12,12,19,12,1032,117.8,8.38,55.94,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","MORC2","ENSG00000133422","","Fatty acyl-CoA biosynthesis","",2613.6,2635.9,2522.2,2921,2816.5,2971.2,0.892406444130582,-0.16422716346390748,0.005512160702128525,2.258678129447623,0.0768862262821706,1.1141514545473765,524]
["Q9Y6Y0","influenza virus NS1A-binding protein [OS=Homo sapiens]",1,1,1,1,642,71.7,5.53,0,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","","IVNS1ABP","ENSG00000116679","","","",55.4,68.6,65.9,143.5,125.7,55.5,0.5848475515860795,-0.7738674791365906,0.17342426993479843,0.7608901250766981,0.40561855646510137,0.39188218487281906,3125]
["Q9Y6Y8","SEC23-interacting protein [OS=Homo sapiens]",29,26,73,26,1000,111,5.54,187.51,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","SEC23IP","ENSG00000107651","","COPII-mediated vesicle transport","",7526.9,7505.5,7276,7629.8,7327.7,8771,0.9401521377246772,-0.08903385875570956,0.34909323005589127,0.4570585733510406,0.5508468088252395,0.2589691621864474,4632]

{"sheet":"CF3-P","index":5,"n_rows":7310,"n_cols":31,"rows_kept":2250,"cut":true,"bounds":{"rows_first":1000,"rows_last":250,"rows_between":1000,"halvings":1}}
["Accession","Description","Coverage [%]","# Peptides","# PSMs","# Unique Peptides","# AAs","MW [kDa]","calc. pI","Score Sequest HT: Sequest HT","Biological Process","Cellular Component","Molecular Function","Gene Symbol","Ensembl Gene ID","KEGG Pathways","Reactome Pathways","WikiPathways","Abundances (Normalized): F7: 133N, Sample, CF3-P","Abundances (Normalized): F7: 134N, Sample, CF3-P","Abundances (Normalized): F7: 135N, Sample, CF3-P","Abundances (Normalized): F7: 126, Sample, DMSO","Abundances (Normalized): F7: 127C, Sample, DMSO","Abundances (Normalized): F7: 128C, Sample, DMSO","Ratio","log2(Ratio)","P-Value","− log10(P-Value)","q-Value","− log10(q-Value)","Rank (P-Value)"]
["A0A096LP01","Small integral membrane protein 26 [OS=Homo sapiens]",17,1,1,1,95,10.9,6.7,3.05,"","other membranes","","SMIM26","ENSG00000232388","","","",77,76.8,73.7,251.3,281.5,85.3,{"$f":"AVERAGE(S2:U2)/AVERAGE(V2:X2)","v":0.3680634201585504},{"$f":"LOG(Y2,2)","v":-1.441973719732649},{"$f":"TTEST(V2:X2,S2:U2,2,2)","v":0.09971937294094484},{"$f":"-LOG10(AA2)","v":1.001220461106328},{"$f":"AA2*7309/AE2","v":0.33743004482655825},{"$f":"-LOG10(AC2)","v":0.47181625037328584},2160]
["A0A0B4J2F0","Protein PIGBOS1 [OS=Homo sapiens]",19,1,1,1,54,6.3,8.5,3.82,"stress response;other biological processes","other membranes;mitochondrion","","PIGBOS1","ENSG00000225973","","","",59.6,62.3,59.8,42.3,98.1,55.7,0.9265680775114737,-0.11003111595803315,0.7897661437638619,{"$f":"-LOG10(AA3)","v":0.10250148783382482},0.8664666383623637,{"$f":"-LOG10(AC3)","v":0.062248154305009816},6662]
["A0A1B0GVM6","Uncharacterized protein C11orf97 [OS=Homo sapiens]",6,1,1,1,126,13.9,9.35,2.08,"","cytoskeleton;other cell component","","C11orf97","ENSG00000257057","","","",208.2,204.6,192.9,184.6,165.2,271.8,0.9744208494208495,-0.03738309235508051,0.8805666605453342,{"$f":"-LOG10(AA4)","v":0.05523776154659025},0.9232623327967074,0.034674882399124383,6971]
["A0AV96","RNA-binding protein 47 [OS=Homo sapiens]",22,9,24,9,593,64.1,7.68,76.54,"RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus","nucleic acid binding activity","RBM47","ENSG00000163694","","","TYROBP causal network in microglia",1536.6,1648.1,1586.8,2427.4,2137.3,2465,0.6787629628575899,-0.5590202494520847,0.00226222192513473,2.6454647928085526,0.060566227292343386,1.2177694779653359,273]
["A0AVK6","Transcription factor E2F8 [OS=Homo sapiens]",2,1,1,1,867,94.1,8.98,2.02,"cell cycle OR cell proliferation;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","E2F8","ENSG00000129173","","TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest","Genotoxicity pathway",76.2,76.5,64.4,55.7,63.9,429.8,0.3951583545686203,-1.3394971844607118,0.42020135146214155,0.37654255513899837,0.6179580840717893,0.20904098198835747,4970]
["A0AVT1-1","Ubiquitin-like modifier-activating enzyme 6 [OS=Homo sapiens]",46,38,125,37,1052,117.9,6.14,376.11,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","UBA6; UBE1L2","ENSG00000033178","Ubiquitin mediated proteolysis","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation","",12764.2,12376,12458.4,11917.7,11594.7,13800.7,1.0076514682510966,0.010996718227131975,0.898124872807411,0.046663276026549155,0.9337688044593694,0.029760639162400186,7030]
["A0FGR8-2","Isoform 2 of Extended synaptotagmin-2 [OS=Homo sapiens]",31,20,56,20,893,98.8,8.68,171.95,"","","","ESYT2","","","","",4324,4452.1,4349.4,3942.7,3944,5552,0.9766941742876916,-0.03402120342900345,0.8554976217433609,0.06778119344628313,0.9092383477275301,0.041322255904332694,6877]
["A0JLT2","Mediator of RNA polymerase II transcription subunit 19 [OS=Homo sapiens]",5,1,1,1,244,26.3,9.82,3.01,"other biological processes","nucleus","other molecular function","MED19","ENSG00000156603","","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","",119.8,119.2,125.7,105.2,117.4,226.6,0.8118878005342831,-0.300647728064489,0.506523048178706,0.29540078827192934,0.6726338951922533,0.17222125161541127,5504]
["A0JNW5-1","UHRF1-binding protein 1-like [OS=Homo sapiens]",9,10,15,10,1464,164.1,6.32,37.87,"","cytosol;other cytoplasmic organelle","other molecular function","UHRF1BP1L","ENSG00000111647","","RND2 GTPase cycle","",1051.8,976.8,1064.2,1131,1203.2,1931.1,0.7251072609195135,-0.46373367444827585,0.2029241574926991,0.6926662484754623,0.4614725162147286,0.33585415901881505,3214]
["A0MZ66","Shootin-1 [OS=Homo sapiens]",37,24,49,24,631,71.6,5.33,145.6,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SHTN1","ENSG00000187164","","Recycling pathway of L1","",5354.8,5541.4,5835.1,6728.1,6456.4,8164.3,0.7837114966649181,-0.3516054340828536,0.04837726672645749,1.3153586725419344,0.2395592428886706,0.6205870681449842,1476]
["A0PJW6","Transmembrane protein 223 [OS=Homo sapiens]",4,1,1,1,202,22,11.02,3.28,"developmental processes","other membranes","","TMEM223","ENSG00000168569","","","",21.1,32.4,26.1,21.1,21,122.1,0.48477466504263095,-1.044613791234156,0.45154491471730435,0.3452990443677121,0.6357815029221301,0.19669211136258838,5191]
["A0PK00","Transmembrane protein 120B [OS=Homo sapiens]",9,2,2,2,339,40.2,8.9,9.39,"cell organization and biogenesis;transport;other biological processes","other membranes;nucleus","","TMEM120B","ENSG00000188735","","","",267.5,280.2,251.4,219.3,255,285.2,1.052139565503621,0.07332608971089102,0.5599643393944205,0.25183962959621986,0.710058875196707,0.1487056398541986,5764]
["A1A4S6","Rho GTPase-activating protein 10 [OS=Homo sapiens]",23,14,19,14,786,89.3,7.18,61.26,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","enzyme regulator activity","ARHGAP10","ENSG00000071205","Bacterial invasion of epithelial cells","Regulation of PAK-2p34 activity by PS-GAP/RHG10; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle","Ectoderm differentiation; Ectoderm differentiation",1589,1557.2,1672,1464.4,1402.6,1580.4,1.0833745559203132,0.11553211325717419,0.1184661262246621,0.9264058124955886,0.3664278106542765,0.4360115722439846,2363]
["A1L0T0","Acetolactate synthase-like protein [OS=Homo sapiens]",30,13,32,13,632,67.8,8.15,108.67,"other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","ILVBL","ENSG00000105135","","","",2244.7,2378.2,2422,2179.6,2147.2,2475.2,1.0357100852690386,0.050620222060766426,0.5276194234056318,0.2776792250236728,0.6864311793648563,0.16340299800525918,5618]
["A2AJT9-1","BCLAF1 and THRAP3 family member 3 [OS=Homo sapiens]",3,2,2,2,711,83.8,9.7,4.71,"other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","BCLAF3","ENSG00000173681","","","",122.2,138.8,135.8,210.3,232.3,338.7,0.5078714962242417,-0.9774645884654024,0.0327027875089347,1.4854152275185277,0.20136872274878154,0.696007984589146,1187]
["A2RRP1-1","neuroblastoma-amplified sequence [OS=Homo sapiens]",17,31,67,31,2371,268.4,5.96,179.73,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","NBAS","ENSG00000151779","","COPI-dependent Golgi-to-ER retrograde traffic","",4937.4,5193.7,5141.7,4878.7,4713.7,6019.2,0.9782981885264804,-0.031653824454950984,0.8003117399318407,0.09674081230731597,0.8730564936062423,0.05895765312416948,6700]
["A2RTX5","Probable threonine--tRNA ligase 2, cytoplasmic [OS=Homo sapiens]",20,13,26,11,802,92.6,6.05,55.39,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","other molecular function","TARS3","ENSG00000185418","Aminoacyl-tRNA biosynthesis","","",1102.4,1139,1200.8,1143.6,1083.2,1076.6,1.042017315493128,0.05937925148255102,0.26541776575499204,0.5760700109699516,0.5214888306191497,0.28275498896787604,3720]
["A2RU49","Hydroxylysine kinase [OS=Homo sapiens]",5,1,1,1,373,41.9,6.84,3.01,"other metabolic processes","mitochondrion","kinase activity","HYKK","ENSG00000188266","Lysine degradation; Metabolic pathways","Lysine catabolism","",32.8,33.8,25.2,35.9,27.7,126.8,0.48214285714285715,-1.0524674198941357,0.36069592268504475,0.4428587669286409,0.5878096987525067,0.23076325242477874,4485]
["A2RU67","Protein FAM234B [OS=Homo sapiens]",6,3,6,3,622,67,5.02,18.88,"","other membranes;cytoskeleton;ER/Golgi","","FAM234B","ENSG00000084444","","","",423.8,424.3,411.4,474,475.7,618.1,0.8033550197729301,-0.3158904084195736,0.09867505965660237,1.005792602368217,0.3357616438687647,0.47396891751176223,2148]
["A2RUC4","tRNA wybutosine-synthesizing protein 5 [OS=Homo sapiens]",7,2,4,2,315,36.5,7.55,10.06,"RNA metabolism OR transcription;other metabolic processes","other cell component","nucleic acid binding activity;other molecular function","TYW5","ENSG00000162971","","Synthesis of wybutosine at G37 of tRNA(Phe)","",255.8,251.1,252.1,249.7,247.3,250.2,1.0157922912205566,0.022605430593166522,0.08006071589578685,1.0965805307909964,0.30701142312817736,0.512845465209331,1906]
["A2RUR9","Coiled-coil domain-containing protein 144A [OS=Homo sapiens]",2,3,7,2,1427,165,5.36,13.7,"","","","CCDC144A","ENSG00000170160","","","",118.4,125.4,112.7,107,121.1,198.6,0.8354816029997657,-0.25932003386986086,0.4608138028598025,0.3364745208694181,0.640564489369018,0.19343714075578905,5258]
["A2RUS2","DENN domain-containing protein 3 [OS=Homo sapiens]",9,7,10,7,1198,135.8,7.06,23.16,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol;other cell component","enzyme regulator activity","DENND3","ENSG00000105339","","RAB GEFs exchange GTP for GDP on RABs","",712.6,751.6,712.7,735.7,702.1,775.8,0.9834206722081675,-0.02411941292514552,0.6495598548656961,0.18738082389782218,0.7743651898896384,0.11105417814108345,6131]
["A3KMH1","von Willebrand factor A domain-containing protein 8 [OS=Homo sapiens]",14,19,30,19,1905,214.7,7.4,99.05,"","mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","VWA8","ENSG00000102763","","","",3121.7,3014.9,2997,2826.6,2908.5,3020.7,1.0431485415381805,0.06094460836764392,0.13947546394232288,0.8555021853056152,0.3931454554394284,0.4054467401909937,2593]
["A3KN83-1","protein strawberry notch homolog 1 [OS=Homo sapiens]",6,5,8,5,1393,154.2,7.88,19.95,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","SBNO1","ENSG00000139697","","","",122.2,146.7,122.2,119.2,118,125.7,1.0777073573987324,0.10796547925361098,0.3312993605363789,0.4797794023788008,0.5720451278432301,0.24256970896883812,4233]
["A4D1E9-1","GTP-binding protein 10 [OS=Homo sapiens]",26,8,19,8,387,42.9,9.03,60.89,"other biological processes","mitochondrion;nucleus;other cell component","other molecular function","GTPBP10","ENSG00000105793","","","",1599.9,1789.6,1663.6,1626,1598.6,2402.9,0.8979298089737895,-0.15532542074859093,0.5166217345464784,0.2868273267824392,0.6799906821178121,0.1674970383710328,5553]
["A4D1P6-1","WD repeat-containing protein 91 [OS=Homo sapiens]",18,10,19,10,747,83.3,6.58,71.16,"transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle","enzyme regulator activity","WDR91","ENSG00000105875","","CDC42 GTPase cycle","",1870.1,1946.8,1863.8,1910,1861.6,1666.9,1.0445343385124575,0.06285992101902248,0.364243631129847,0.4386080332143758,0.5888645653457314,0.22998457836469707,4521]
["A5A3E0","POTE ankyrin domain family member F [OS=Homo sapiens]",13,11,339,2,1075,121.4,6.2,1022.65,"","other cell component","","POTEF","ENSG00000196604","","","",597.2,504.8,584.5,364.9,434.4,225.5,1.6456869633099143,0.7186899375638425,0.03140308030231145,1.5030277502489346,0.19769604989629144,0.7040020081035355,1161]
["A5LHX3","proteasome subunit beta type-11 [OS=Homo sapiens]",5,1,1,1,300,32.5,6.46,2.88,"protein metabolism;other metabolic processes;developmental processes","cytosol;nucleus;other cell component","other molecular function","PSMB11","ENSG00000222028","Proteasome","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling","",41.7,43,35.9,33.2,26.9,108.3,0.7161520190023752,-0.4816622311663114,0.5764557169082472,0.2392340494118917,0.7204710729963028,0.14238345147772277,5848]
["A5PLN9-1","Trafficking protein particle complex subunit 13 [OS=Homo sapiens]",4,2,4,2,417,46.5,5.6,9.61,"","cytosol;ER/Golgi","","C5orf44; TRAPPC13","ENSG00000113597","","RAB GEFs exchange GTP for GDP on RABs","",442.7,478,479.4,481.4,491.6,621,0.8783563362609785,-0.18712175619253468,0.23694951654822513,0.6253441730614455,0.4966630388445591,0.30393815855344913,3487]
["A5YKK6","CCR4-NOT transcription complex subunit 1 [OS=Homo sapiens]",19,40,103,40,2376,266.8,7.11,284.22,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","CNOT1","ENSG00000125107","RNA degradation","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","Ciliary landscape",8770.5,9132.5,8972.1,9575.5,9325.3,14309,0.8092520882390137,-0.30533891163773663,0.26351132376561054,0.5792007172891912,0.5204010444211963,0.28366184050033,3701]
["A6NC62","Putative RBAK downstream neighbor protein [OS=Homo sapiens]",6,1,1,1,111,12.3,8.76,2.34,"","","","RBAKDN","","","","",165.3,186,165.4,161.9,173.2,181.8,0.9996130779647899,-5.5831852124427325E-4,0.9944302024964837,2.4256939215490086E-3,0.9968852489434644,1.3548302729204484E-3,7291]
["A6NC98","Coiled-coil domain-containing protein 88B [OS=Homo sapiens]",41,50,114,50,1476,164.7,5.11,346.24,"cell organization and biogenesis;stress response;transport;other biological processes","cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","CCDC88B","ENSG00000168071","","","",7982.3,8501.1,8217.3,9566.4,9578.2,10639.8,0.8293166892735796,-0.2700049692841006,0.011799382221368223,1.9281407303950875,0.12795502174477794,0.8929426650464345,674]
["A6ND36-1","Protein FAM83G [OS=Homo sapiens]",3,2,2,2,823,90.8,6.39,5.4,"signal transduction","cytosol;nucleus","other molecular function","FAM83G","ENSG00000188522","","","",55.7,63.1,51.9,76.3,65,124.5,0.6422121896162528,-0.6388780462484365,0.16244017291619464,0.7893065568789399,0.4198285798601367,0.3769280001198287,2828]
["A6NDG6","glycerol-3-phosphate phosphatase [OS=Homo sapiens]",38,10,26,10,321,34,6.14,84.02,"protein metabolism;other metabolic processes;other biological processes","other cell component","other molecular function","PGP","ENSG00000184207","Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism","Glycolysis","",3460.4,3233.1,3359.7,3260.2,3459.1,3532.5,0.9806277921925908,-0.028222444940043133,0.5611720806312532,0.25090394407526434,0.7108503877528302,0.14822179534702276,5770]
["A6NDU8","UPF0600 protein C5orf51 [OS=Homo sapiens]",42,8,16,8,294,33.6,5.26,52.53,"","cytosol;nucleus","","C5orf51","ENSG00000205765","","","",1487.8,1501.6,1427.1,1512.7,1549.9,888.6,1.117761692650334,0.1606126376635298,0.5119106207536991,0.29080585992645697,0.6768369622085358,0.16951593240862603,5528]
["A6NED2","RCC1 domain-containing protein 1 [OS=Homo sapiens]",7,1,2,1,376,40.1,5.27,8.95,"cell organization and biogenesis","plasma membrane;other membranes;cytosol;other cell component","","RCCD1","ENSG00000166965","","","",18,21,11.4,10.1,13.5,17.5,1.2262773722627738,0.2942853398182336,0.43200349632619844,0.36451273830307324,0.6241378838996213,0.20471945582766765,5059]
["A6NEE1","Pleckstrin homology domain-containing family D member 1 [OS=Homo sapiens]",1,1,3,1,506,59.2,6.44,6.54,"","","","PLEKHD1","ENSG00000175985","","","",466.7,477.9,464.9,566.3,547.1,640.4,0.8036834302657087,-0.31530075706942495,0.016210204895911864,1.790211495663422,0.14773115658880276,0.8305279020636126,802]
["A6NF36","Coiled-coil domain-containing protein 182 [OS=Homo sapiens]",5,1,1,1,153,17.5,6.58,2.1,"developmental processes","","","CCDC182","ENSG00000166329","","","",347.3,369.2,304.8,299.4,278.1,163,1.3792032410533424,0.46383506979928496,0.11380981919039092,0.9438202666207617,0.359479675221507,0.4443256593525195,2314]
["A6NFI3","Zinc finger protein 316 [OS=Homo sapiens]",1,1,1,1,1004,108.4,5.31,1.81,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF316","ENSG00000205903","Herpes simplex virus 1 infection","","",96.1,98.2,88.2,130.7,138,329.6,0.4721711515961893,-1.082618195465043,0.18165485241066628,0.740752996661549,0.43964083320184105,0.3569019777347267,3020]
["A6NFQ2","TRPM8 channel-associated factor 2 [OS=Homo sapiens]",10,7,10,7,919,100.8,7.17,35.62,"other biological processes","plasma membrane;other membranes;other cell component","other molecular function","TCAF2","ENSG00000170379","","","",822.6,772.4,748.8,721.7,739.8,932.8,0.9789082404042936,-0.030754462145182588,0.8241644211344962,0.08398613773484477,0.8896496461485797,0.050780989648296256,6771]
["A6NHR9-1","structural maintenance of chromosomes flexible hinge domain-containing protein 1 [OS=Homo sapiens]",19,35,74,35,2005,226.2,7.3,199.26,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SMCHD1","ENSG00000101596","","","",8854,8861.3,8847.6,9475,9740.7,10286.6,0.9003670900234898,-0.15141477013396254,0.01484363171359906,1.828459829500826,0.1421914864937032,0.8471264055717336,763]
["A6NI79","Coiled-coil domain-containing protein 69 [OS=Homo sapiens]",15,5,6,5,296,34.8,5.76,11.39,"cell cycle OR cell proliferation;cell organization and biogenesis","cytoskeleton;nucleus;other cell component","cytoskeletal activity","CCDC69","ENSG00000198624","","","",578.9,591.2,582.6,518.2,518.1,400.8,1.2196089346600791,0.2864186244522415,0.05535504949700782,1.2568427565619096,0.2562318282290248,0.5913669246862309,1579]
["A6NIH7","Protein unc-119 homolog B [OS=Homo sapiens]",35,5,10,5,251,28.1,5.68,36.45,"cell organization and biogenesis;transport;developmental processes","cytosol;other cell component","other molecular function","UNC119B","ENSG00000175970","","Trafficking of myristoylated proteins to the cilium","",839.8,849,818.1,801.2,836.9,1088.4,0.9194571795342014,-0.12114570710404127,0.46550801471554365,0.3320728373104147,0.6443935756734676,0.19084879796025397,5280]
["A6NJ78","Probable methyltransferase-like protein 15 [OS=Homo sapiens]",16,4,5,4,407,46.1,8.62,15.12,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","other molecular function","METTL15","ENSG00000169519","","","",163.4,195.6,158.8,170.3,160.6,214.8,0.9488730071467839,-0.07571307847253142,0.6707785467247714,0.17342083573208295,0.7877121462100505,0.10363245782974254,6224]
["A6NK58","Putative lipoyltransferase 2, mitochondrial [OS=Homo sapiens]",4,1,1,1,231,25.2,8.27,2.54,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","other molecular function","LIPT2","ENSG00000175536","Lipoic acid metabolism; Metabolic pathways; Biosynthesis of cofactors","Glyoxylate metabolism and glycine degradation","",76.7,75,77.6,78.9,84.2,198.5,0.6341261061946901,-0.6571583228343946,0.3215832028871153,0.492706643642336,0.566101066932063,0.24710602659876452,4152]
["A6NK97-2","Isoform 2 of Solute carrier family 22 member 20 [OS=Homo sapiens]",5,1,1,1,347,37,7.78,0,"","","","SLC22A20P","","","","",21.6,24.4,33.9,25,16.6,38.5,0.9975031210986268,-0.003606739480733186,0.9932300202338956,2.9501624311118386E-3,0.9960919618399483,1.7005645120806987E-3,7288]
["A6NKF1","SAC3 domain-containing protein 1 [OS=Homo sapiens]",7,2,2,2,404,43.5,8.69,6.58,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;nucleus;other cell component","","SAC3D1","","","","",172.8,181.4,186.6,223.8,183.7,237.9,0.8379299659126124,-0.2550984262047577,0.10548102917180235,0.9768256414738423,0.34618807463704687,0.4606878966239075,2227]
["A7E2V4","Zinc finger SWIM domain-containing protein 8 [OS=Homo sapiens]",6,6,7,6,1837,197.2,6.8,22.41,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","other molecular function","ZSWIM8","ENSG00000214655","","Regulation of expression of SLITs and ROBOs","",542.4,573.9,581.3,590.7,586.6,896.1,0.8187518086235169,-0.28850190643168705,0.29150751076014136,0.5353502510604994,0.5404942658919009,0.26720890911995077,3942]
["A8MVU1","Putative neutrophil cytosol factor 1C [OS=Homo sapiens]",33,8,20,8,366,41.8,8.84,66.73,"other metabolic processes","other cell component","enzyme regulator activity;other molecular function","NCF1C","","","","",1291.1,1361.7,1299.8,1575.4,1490.5,2348.5,0.7300162529550829,-0.4539995106252908,0.14980975390217674,0.8244599094136735,0.40434250046935366,0.3932506075428073,2708]
["A8MW92","PHD finger protein 20-like protein 1 [OS=Homo sapiens]",1,1,1,1,1017,114.9,6.83,2.6,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","PHF20L1","ENSG00000129292","","","",50.5,55.6,54.3,77.4,78,64.2,0.7304189435336975,-0.45320391255027853,0.014271851004059848,1.845519696912207,0.13871404120834233,0.8578795756198763,752]
["A8MXV4","nucleoside diphosphate-linked moiety X motif 19 [OS=Homo sapiens]",12,2,13,2,375,42.2,7.64,35.47,"other metabolic processes","cytosol;other cytoplasmic organelle","other molecular function","NUDT19","ENSG00000213965","Peroxisome","Peroxisomal lipid metabolism; Peroxisomal protein import","",1053.6,1037.9,1209,968.4,908.5,307.5,1.510941219556858,0.5954475361457995,0.1630587773900842,0.787655818327029,0.41994242563217954,0.37681024756451126,2838]
["A9UHW6","MIF4G domain-containing protein [OS=Homo sapiens]",18,4,6,4,222,25.4,5.33,20.28,"other biological processes","cytosol;ER/Golgi;nucleus","nucleic acid binding activity;other molecular function","MIF4GD","ENSG00000125457","","","",491.4,470.3,468.8,574.4,609.8,916,0.6811256070850396,-0.5540072232155864,0.10922173078451766,0.9616909456890519,0.34967219899432306,0.45633889529531424,2283]
["B2RTY4","unconventional myosin-IXa [OS=Homo sapiens]",1,3,4,3,2548,292.5,8.88,9.32,"cell organization and biogenesis;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","MYO9A","ENSG00000066933","","RHOA GTPase cycle; RHOB GTPase cycle; RHOV GTPase cycle","",199.8,219.7,216.3,203.7,199,631.4,0.6148341553041291,-0.7017307829504498,0.40718953938990915,0.3902033874581185,0.6112442685152693,0.21378520012003985,4869]
["B5ME19","eukaryotic translation initiation factor 3 subunit C-like protein [OS=Homo sapiens]",44,41,177,1,914,105.4,5.64,520.95,"cell organization and biogenesis;protein metabolism;other metabolic processes","translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3CL","ENSG00000205609","","","",591.3,607.8,525,681.2,692.4,1038.4,0.7148009950248755,-0.48438645223088234,0.12848960634269158,0.8911320014422451,0.37746404049788296,0.42312441557705327,2488]
["B7ZC32","Kinesin-like protein KIF28P [OS=Homo sapiens]",1,1,1,1,967,108.2,8.43,1.83,"cell organization and biogenesis;transport;other biological processes","other membranes;cytoskeleton;mitochondrion","cytoskeletal activity;other molecular function","KIF28P","","","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",86.8,94.4,84.6,74.7,69.1,108,1.0555996822875295,0.07806282155715763,0.727825334510463,0.137972831345825,0.8239893695689242,0.08407839117586602,6456]
["B9A064-1","Immunoglobulin lambda-like polypeptide 5 [OS=Homo sapiens]",48,8,196,8,214,23,8.84,691.91,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","IGLL5","ENSG00000254709","","","",27301.6,30276.3,27030.7,42363.8,37975.4,53210.2,0.6335378519109781,-0.6584972764165071,0.024634605117081963,1.6084543949010184,0.17791929723394473,0.7497769455208257,1012]
["C9J798","Ras GTPase-activating protein 4B [OS=Homo sapiens]",17,12,17,12,803,90.4,7.74,47.22,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol","enzyme regulator activity;other molecular function","RASA4B","ENSG00000170667","","","Ras signaling",1778.9,1741.1,1812.8,1996.9,2038.5,2414.6,0.8267906976744187,-0.27440593797509283,0.050339314526923605,1.2980927025580462,0.24496008646956366,0.6109046733422229,1502]
["C9JI98","Transmembrane protein 238 [OS=Homo sapiens]",6,1,1,1,176,18,11.53,2.83,"","other membranes","","TMEM238","ENSG00000233493","","","",167.1,141.1,129.7,141.9,164.1,152,0.956113537117904,-0.0647461485316551,0.6281517884099934,0.20193539940996796,0.7601260631603712,0.11911437614712679,6040]
["C9JRZ8","Aldo-keto reductase family 1 member B15 [OS=Homo sapiens]",5,2,7,1,316,36.5,6.7,14.99,"other metabolic processes","cytosol;mitochondrion","other molecular function","AKR1B15","ENSG00000227471","","Estrogen biosynthesis","",557.3,617.9,709.6,428.9,324.6,145.3,2.097018246550957,1.0683394146505536,0.024897804717512784,1.6038389437115168,0.1792887238229566,0.7464470240767755,1015]
["L0R6Q1","SLC35A4 upstream open reading frame protein [OS=Homo sapiens]",47,5,18,5,103,11.1,8.1,62.31,"stress response","other membranes","","SLC35A4","ENSG00000176087","","","",2412.6,2466.9,2652.2,1898.8,2251.4,1431.4,1.3493801060627775,0.432296797425185,0.05893640135929763,1.2296163855799624,0.2620232101795051,0.5816602369000211,1644]
["O00115","Deoxyribonuclease-2-alpha [OS=Homo sapiens]",10,4,11,4,360,39.6,8.05,21.95,"cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes","other cytoplasmic organelle","nucleic acid binding activity;other molecular function","DNASE2","ENSG00000105612","Lysosome","Lysosome Vesicle Biogenesis","",1226.4,1091,1315.8,1199.4,1293.7,1838.2,0.8388243714358276,-0.2535593163822552,0.3290207948756798,0.48277665276625553,0.571893695540153,0.2426846910162136,4205]
["O00116","Alkyldihydroxyacetonephosphate synthase, peroxisomal [OS=Homo sapiens]",36,17,47,17,658,72.9,7.34,166.8,"other metabolic processes","cytosol;nucleus;other cytoplasmic organelle","other molecular function","AGPS","ENSG00000018510","Ether lipid metabolism; Metabolic pathways; Peroxisome","Plasmalogen biosynthesis; TYSND1 cleaves peroxisomal proteins","Triacylglyceride synthesis",4392.3,4672.9,4565.4,4356.3,4094.6,5517,0.9758517744256475,-0.03526606650597564,0.8128496889848373,0.08998975610304771,0.8822569612103023,0.05440490627114458,6734]
["O00124-1","UBX domain-containing protein 8 [OS=Homo sapiens]",8,1,1,1,270,30.5,7.78,3.78,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","UBXN8","ENSG00000104691; ENSPTRG00000049759","Protein processing in endoplasmic reticulum","","",20,11.7,18.8,20.3,12.5,31.2,0.7890625,-0.34178851724820525,0.49560790932854437,0.3048617714034538,0.6652705618516678,0.17700169361127455,5445]
["O00139","Kinesin-like protein KIF2A [OS=Homo sapiens]",38,19,40,1,706,79.9,6.68,110.76,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KIF2A","ENSG00000068796","","COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Kinesins; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",3516.7,3736,3520.2,3818.6,3718.5,4630,0.8854123003838219,-0.17557867900808208,0.1933761443112037,0.7135971033297012,0.4517054134773371,0.34514470459192154,3129]
["O00139-2","Isoform 2 of Kinesin-like protein KIF2A [OS=Homo sapiens]",39,19,42,1,660,75,6.4,112.68,"","","","KIF2A","","","","",183.7,163.6,153.9,167.5,193,471.5,{"$f":"AVERAGE(S66:U66)/AVERAGE(V66:X66)","v":0.6024038461538461},{"$f":"LOG(Y66,2)","v":-0.731197113706594},{"$f":"TTEST(V66:X66,S66:U66,2,2)","v":0.3224079918443516},0.49159420144857063,{"$f":"AA66*7309/AE66","v":0.566325405525202},0.24693395535754498,4161]
["O00142","thymidine kinase 2, mitochondrial [OS=Homo sapiens]",15,3,5,3,265,31,8.46,13.08,"DNA metabolism;other metabolic processes","mitochondrion;other cell component","kinase activity;other molecular function","TK2","ENSG00000166548","Pyrimidine metabolism; Drug metabolism; Metabolic pathways","Pyrimidine salvage","Pyrimidine metabolism",535.1,526.5,549.8,454.1,439.1,490.1,1.1648955396515577,0.22020058905675063,0.010162723200549973,{"$f":"-LOG10(AA67)","v":1.992989903026143},0.12097613008602566,{"$f":"-LOG10(AC67)","v":0.9173003122833377},614]
["O00148","ATP-dependent RNA helicase DDX39A [OS=Homo sapiens]",56,22,194,9,427,49.1,5.68,472.72,"RNA metabolism OR transcription;other metabolic processes;transport","nucleus;other cell component","other molecular function","DDX39A","ENSG00000123136","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","",24242,25838.5,25538.1,25702.3,23819.2,21174.1,1.0696365827576257,0.0971207131584036,0.30669977367751594,0.5132865444956437,0.5558315511552104,0.2550568046192894,4033]
["O00151","PDZ and LIM domain protein 1 [OS=Homo sapiens]",73,16,96,16,329,36,7.02,326.94,"cell organization and biogenesis;stress response;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","PDLIM1","ENSG00000107438","","","",11924.5,10896.8,11547.3,12502.6,13141.8,10253.8,0.9573906212567761,-0.06282042161912624,0.6111289302656558,0.2138671567034435,0.7459487894642083,0.12729098649048523,5988]
["O00154","cytosolic acyl coenzyme A thioester hydrolase [OS=Homo sapiens]",39,14,70,14,380,41.8,8.54,221.44,"other metabolic processes","cytosol;mitochondrion;nucleus","other molecular function","ACOT7","ENSG00000097021","Fatty acid elongation; Biosynthesis of unsaturated fatty acids","Mitochondrial Fatty Acid Beta-Oxidation","",6436.9,6542.2,6635,5621.5,5603.7,6431.7,1.110846184777622,0.1516590653126967,0.07953114136277187,1.099462784880366,0.3067509827021106,0.5132140373004842,1895]
["O00159-1","Unconventional myosin-Ic [OS=Homo sapiens]",24,25,63,25,1063,121.6,9.41,176.7,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","MYO1C","ENSG00000197879","Pathogenic Escherichia coli infection","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Translocation of SLC2A4 (GLUT4) to the plasma membrane","VEGFA-VEGFR2 signaling pathway; Insulin signaling",8940.2,9020.5,9249.7,8970.4,8543.7,8856.5,1.0318460710033144,0.04522776808331313,0.15054635676790273,0.8223297499801231,0.4046867677883785,0.3928809956836503,2719]
["O00161","Synaptosomal-associated protein 23 [OS=Homo sapiens]",57,11,42,11,211,23.3,5.01,126.62,"cell-cell signaling;cell organization and biogenesis;stress response;transport","plasma membrane;other membranes;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","SNAP23","ENSG00000092531","SNARE interactions in vesicular transport; Platelet activation","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; ER-Phagosome pathway; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; trans-Golgi Network Vesicle Budding","Insulin signaling",4665.9,4300.8,4448.2,3792.4,4336.9,4031.3,1.1031445816818253,0.1416218875799895,0.09252191508884264,1.0337553864514728,0.32731978576202847,0.4850277417511017,2066]
["O00165","HCLS1-associated protein X-1 [OS=Homo sapiens]",45,10,25,10,279,31.6,4.92,86.17,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","HAX1","ENSG00000143575","","","",2727.7,2454.1,2673.4,2995.9,3300.3,4735.6,0.7120506173063325,-0.4899482936659091,0.12289885447310994,0.9104521651064326,0.3705724947788616,0.4311268187167082,2424]
["O00170","AH receptor-interacting protein [OS=Homo sapiens]",27,7,27,7,330,37.6,6.29,89.27,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","AIP","ENSG00000110711","Cushing syndrome; Chemical carcinogenesis","Aryl hydrocarbon receptor signalling; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","Aryl hydrocarbon receptor Netpath; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway",2417.1,2490,2923.3,3532,3435.6,3761.4,0.7298350265635195,-0.45435770384866625,0.006440065079152898,2.1911097439174885,0.09725296624695977,1.012097143677928,484]
["O00178","GTP-binding protein 1 [OS=Homo sapiens]",34,16,39,16,669,72.4,8.34,131.59,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;other cytoplasmic organelle","nucleic acid binding activity;other molecular function","GTPBP1","ENSG00000100226","","","",3454.4,3253,3386,3173.6,3308.3,3119.7,1.0512206298950177,0.07206549351564338,0.11459612645923924,0.9408300620004706,0.36087164510580766,0.44264724057241533,2321]
["O00186","syntaxin-binding protein 3 [OS=Homo sapiens]",19,9,24,9,592,67.7,7.8,66.92,"cell adhesion;cell-cell signaling;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","STXBP3","ENSG00000116266","","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Disinhibition of SNARE formation","Insulin signaling",2404.9,2270.7,2399.2,2164.9,2140.5,2261.8,1.0772932147642833,0.10741097217828702,0.042009268973910614,1.3766548757902408,0.2241209831608122,0.6495174810626745,1370]
["O00189","AP-4 complex subunit mu-1 [OS=Homo sapiens]",7,3,3,3,453,49.9,7.2,9.07,"transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","AP4M1","ENSG00000221838","Lysosome","Lysosome Vesicle Biogenesis","",228.1,198.8,261.2,210,207.8,360.2,0.8844473007712083,-0.17715191147536952,0.6056765364760921,0.21775925030291132,0.7421441416770758,0.12951173642529906,5965]
["O00193","Small acidic protein [OS=Homo sapiens]",33,6,29,6,183,20.3,4.72,110.48,"","","","SMAP","ENSG00000110696","","","",3285.7,2913.7,2676.6,3074.4,3436.3,3777.8,0.8627107936045099,-0.21305108885490134,0.1556248161458837,0.8079211486324799,0.41182540956200725,0.38528686099111936,2762]
["O00203-1","AP-3 complex subunit beta-1 [OS=Homo sapiens]",36,36,116,35,1094,121.2,6.04,322.39,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","AP3B1","ENSG00000132842","Lysosome","Golgi Associated Vesicle Biogenesis; Signaling by BRAF and RAF1 fusions","",16419.2,16427.7,17244.2,15594.9,15066.6,11748.1,1.1811264430694939,0.24016341776193764,0.10675372202013488,0.9716169741518699,0.3478657843268684,0.4585882858508647,2243]
["O00214-1","Galectin-8 [OS=Homo sapiens]",10,3,6,3,317,35.8,8.25,21.56,"other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;cytosol;other cell component","signal transduction activity or receptor binding;other molecular function","LGALS8","ENSG00000116977","","","",403.6,473.1,490.2,443.3,400.6,1220.6,0.6620973601356261,-0.5948847167414496,0.43423977832633354,0.3622703957218923,0.6248983145869603,0.20419064666651704,5079]
["O00217","NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [OS=Homo sapiens]",31,6,19,6,210,23.7,6.34,49.75,"cell organization and biogenesis;other metabolic processes;stress response;transport","other membranes;mitochondrion","transporter activity;other molecular function","NDUFS8","ENSG00000110717","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",1716.3,1714,2345.7,2671.5,2675.8,2494.1,0.7366031575994083,-0.44104051323042887,0.034505480265944584,1.4621119234703277,0.20554242482786386,0.687098524313359,1227]
["O00221","NF-kappa-B inhibitor epsilon [OS=Homo sapiens]",22,7,15,7,500,52.8,6.68,46.7,"other biological processes","cytosol;nucleus;other cell component","","NFKBIE","ENSG00000146232","Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; Neurotrophin signaling pathway; Adipocytokine signaling pathway; Epstein-Barr virus infection; PD-L1 expression and PD-1 checkpoint pathway in cancer","Activation of NF-kappaB in B cells","TNF-alpha signaling pathway; Apoptosis; Oxidative damage response; Canonical NF-kB pathway; IL-18 signaling pathway; STING pathway in Kawasaki-like disease and COVID-19",1462.9,1427.2,1340.8,1579.3,1686.8,5556.6,0.479547077425278,-1.0602556424508722,0.3071218958604119,0.5126892199868548,0.5557697293497773,0.2551051112728701,4039]
["O00231","26S proteasome non-ATPase regulatory subunit 11 [OS=Homo sapiens]",69,27,96,26,422,47.4,6.48,321.34,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","PSMD11","ENSG00000108671","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection","Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling pathway",15442.9,15801.1,15195.4,17054.6,15760.9,19822.4,0.8822426426586167,-0.1807526009894032,0.1631052979050261,0.7875319321936265,0.419766416333745,0.37699231035669123,2840]
["O00232-1","26s proteasome non-atpase regulatory subunit 12 [OS=Homo sapiens]",61,28,163,28,456,52.9,7.65,457.29,"protein metabolism;other metabolic processes","non-structural extracellular;cytosol;nucleus;other cell component","","PSMD12","ENSCANG00000030312; ENSCATG00000032968; ENSCSAG00000004164; ENSG00000197170; ENSMFAG00000032701; ENSMLEG00000034943; ENSMMUG00000002132; ENSMNEG00000032475; ENSNLEG00000001265; ENSPANG00000020562; ENSPPYG00000008565; ENSRROG00000042400","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection","Activation of NF-kappaB in B cells; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease",15767.8,17376,17474.8,15355.9,13956.8,11641,1.2359957708338931,0.305673806828527,0.05706377909775539,1.2436394702016513,0.259538992797445,0.5857973850810229,1607]
["O00233-1","26S proteasome non-ATPase regulatory subunit 9 [OS=Homo sapiens]",30,6,24,6,223,24.7,6.95,72.5,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PSMD9","ENSG00000110801","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease",2175.4,2019.3,2188.7,2237.1,2323,2075.8,0.9619493964646844,-0.05596709214947871,0.40547011129044735,0.39204115373405496,0.6102926366190032,0.21446186991728317,4856]
["O00244","Copper transport protein ATOX1 [OS=Homo sapiens]",40,3,9,3,68,7.4,7.24,33.66,"stress response;transport;other biological processes","cytosol","other molecular function","ATOX1","ENSG00000177556","Mineral absorption","Detoxification of Reactive Oxygen Species; Ion influx/efflux at host-pathogen interface","Copper homeostasis",1192.8,1027.4,1088.4,1138.8,1217.3,991.6,0.9883203393374556,-0.01694936373737957,0.8812780842718224,0.05488702983040448,0.9236107711417766,0.03451101098638926,6974]
["O00255-1","Menin [OS=Homo sapiens]",23,10,17,10,615,68,6.55,59.91,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","MEN1","ENSG00000133895","Cushing syndrome; Transcriptional misregulation in cancer","RHO GTPases activate IQGAPs; Formation of the beta-catenin:TCF transactivating complex; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",1423.2,1378.1,1317.5,1427.1,1456.8,1922,0.8570299007469986,-0.2225825557690804,0.233035690884907,0.6325775589425636,0.493411895908976,0.3067903841017626,3452]
["O00257-1","E3 SUMO-protein ligase CBX4 [OS=Homo sapiens]",5,2,3,2,560,61.3,9.36,8.25,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","CBX4","ENSG00000141582; ENSPTRG00000040905","","SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Oxidative Stress Induced Senescence; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN gene transcription","",224.6,202.6,216.7,201.9,223.2,266,0.9317030820431196,-0.10205782918436475,0.47373003364497046,0.3244690808983729,0.6491362609507104,0.18766413036825724,5334]
["O00258-1","Tail-anchored protein insertion receptor WRB [OS=Homo sapiens]",12,2,3,2,174,19.8,9.67,7.23,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;ER/Golgi;nucleus","","GET1; WRB","ENSANAG00000014374; ENSCANG00000035340; ENSCATG00000041953; ENSCCAG00000026562; ENSCSAG00000008355; ENSG00000182093; ENSMLEG00000038301; ENSMNEG00000036276; ENSNLEG00000033928; ENSPANG00000032093; ENSPPAG00000034665; ENSPPYG00000011427; ENSPTRG00000013915; ENSSBOG00000020756","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",405.3,387.6,424.2,346.9,358.3,271.4,1.246262543518329,0.31760802528996557,0.05182680209635068,1.2854455878950952,0.24806948036819065,0.6054266630675434,1527]
["O00264","Membrane-associated progesterone receptor component 1 [OS=Homo sapiens]",61,12,49,10,195,21.7,4.7,143.13,"other metabolic processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","PGRMC1","ENSG00000101856","","Neutrophil degranulation","",3100.4,2930.8,3617.7,3056.2,3665.6,2840.3,1.0090775038955881,0.013036987320043032,0.9327394880293548,0.030239636756788025,0.9565585685430833,0.01928843366976871,7127]
["O00267","Transcription elongation factor Spt5 [OS=Homo sapiens]",35,32,126,32,1087,120.9,5.06,422.29,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","SUPT5H","ENSG00000196235","","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE","Initiation of transcription and translation elongation at the HIV-1 LTR; mRNA processing",10782.3,11313.3,11187.1,10375.5,10216.4,9399.7,1.1097340588698166,0.15021398475704237,0.03268157365079833,1.4856970399179568,0.20174799139669342,0.6951907804208848,1184]
["O00268","Transcription initiation factor TFIID subunit 4 [OS=Homo sapiens]",8,6,7,6,1085,110,9.94,21.59,"RNA metabolism OR transcription;other metabolic processes;developmental processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","TAF4","ENSG00000130699","Basal transcription factors; Huntington disease","RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation","",623.5,689.4,640.1,777.7,756.3,749.8,0.8551536912163936,-0.2257443653806171,0.006854976397294469,2.163994036212531,0.09960839460800253,1.0017040593844853,503]
["O00273-1","DNA fragmentation factor subunit alpha [OS=Homo sapiens]",50,11,30,3,331,36.5,4.79,101.46,"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","DFFA","ENSG00000160049","Apoptosis","Apoptosis induced DNA fragmentation","Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis",3074.6,2980,3113.1,3664.1,3806.5,5204,0.7233127672668171,-0.4673084778449271,0.07667762438822413,1.1153313508157205,0.302448330627917,0.5193488082506451,1853]
["O00273-2","Isoform DFF35 of DNA fragmentation factor subunit alpha [OS=Homo sapiens]",55,9,25,1,268,29.4,4.61,92.3,"","","","DFFA","","","","",72.8,77.2,87.3,90.3,72.7,135,0.7963087248322149,-0.3286002301555756,0.3476768643615048,0.4588242078339412,0.5805734981992777,0.23614279256308227,4377]
["O00287","Regulatory factor X-associated protein [OS=Homo sapiens]",7,1,1,1,272,28.2,5.54,2.31,"other biological processes","nucleus","nucleic acid binding activity","RFXAP","ENSG00000133111","Antigen processing and presentation; Tuberculosis; Primary immunodeficiency","","",9.7,13.6,12.5,12.7,11.1,3.2,1.325925925925926,0.4070001802134256,0.4055002718298279,0.39200885032050775,0.6100867613841523,0.2146083989056466,4858]
["O00291","Huntingtin-interacting protein 1 [OS=Homo sapiens]",4,3,3,2,1037,116.1,5.3,7.67,"cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","HIP1","ENSG00000127946","Huntington disease; Pathways of neurodegeneration","Clathrin-mediated endocytosis; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants","",104.1,90.6,81.5,94.5,91.5,141.6,0.843101343101343,-0.24622203738295795,0.3830196472298207,0.4167789480557965,0.5976709226308197,0.22353787257214908,4684]
["O00299","chloride intracellular channel protein 1 [OS=Homo sapiens]",86,18,273,17,241,26.9,5.17,1010.2,"other metabolic processes;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;mitochondrion;nucleus;other cell component","transporter activity","CLIC1","ENSG00000206394; ENSG00000213719; ENSG00000223639; ENSG00000226248; ENSG00000226417; ENSG00000226651; ENSG00000230685","","","VEGFA-VEGFR2 signaling pathway",29613.5,28521.9,30352,29428.6,30336.2,19887.3,1.1109236291321885,0.15175964151606708,0.43324771559617703,0.3632637185311609,0.6243311422106581,0.20458500152086423,5072]
["O00300","Tumor necrosis factor receptor superfamily member 11B [OS=Homo sapiens]",2,1,1,1,401,46,8.29,2.56,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","TNFRSF11B","ENSG00000164761","Cytokine-cytokine receptor interaction; Osteoclast differentiation","TNFs bind their physiological receptors","Osteoclast signaling; RANKL/RANK signaling pathway; Ectoderm differentiation; Vitamin D receptor pathway; Osteoblast signaling; IL-18 signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta; Overlap between signal transduction pathways contributing to LMNA laminopathies; Monoamine transport",173.3,199.1,156.1,149.9,131.5,138,1.260133524082022,0.3335766101734528,0.055657105802475376,1.2544793809465413,0.2568167842868008,0.5903765963160431,1584]
["O00303","Eukaryotic translation initiation factor 3 subunit F [OS=Homo sapiens]",47,12,71,12,357,37.5,5.45,236.86,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3F","ENSG00000175390","","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","Translation factors; VEGFA-VEGFR2 signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell",7195,7174.3,7281.6,7458,7639.6,7674.9,0.9507476122516194,-0.07286568427322423,0.007500003160096646,2.1249385536200003,0.10461359369684424,0.9804118787197541,524]
["O00308","NEDD4-like E3 ubiquitin-protein ligase WWP2 [OS=Homo sapiens]",9,6,6,6,870,98.9,7.12,10.1,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","WWP2","ENSG00000198373","Ubiquitin mediated proteolysis","RHOQ GTPase cycle; Regulation of PTEN stability and activity; RHOJ GTPase cycle; NOTCH3 Activation and Transmission of Signal to the Nucleus; RHOU GTPase cycle","",652,644.4,682.8,781,766,837.9,0.8298880456203614,-0.26901136917758084,0.00553375853625324,2.256979795079539,0.09192327532153395,1.0365745096817534,440]
["O00327-1","Isoform BMAL1A of Aryl hydrocarbon receptor nuclear translocator-like protein 1 [OS=Homo sapiens]",2,1,1,1,583,64.2,6.98,2.86,"","","","ARNTL","","","","",32.9,36.4,35.1,40.7,36.4,23.8,1.034687809712587,0.049195537463527485,0.832614697519767,0.079555927108388,0.8949383564958789,0.04820687793065139,6800]
["O00330-1","Pyruvate dehydrogenase protein X component, mitochondrial [OS=Homo sapiens]",29,14,42,14,501,54.1,8.66,119.68,"other metabolic processes","mitochondrion;other cell component","other molecular function","PDHX","ENSG00000110435","Metabolic pathways","Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid","Amino acid metabolism",6528,6422.9,6205.3,6065,5880.9,8357.9,0.9434785606635212,-0.08393836007790273,0.6584271123624726,0.1814922942797132,0.7806072610311943,0.10756741332749067,6165]
["O00391","Sulfhydryl oxidase 1 [OS=Homo sapiens]",2,1,1,1,747,82.5,8.92,2.8,"cell organization and biogenesis;other biological processes","non-structural extracellular;other membranes;ER/Golgi;other cell component","other molecular function","QSOX1","ENSG00000116260","","Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",31.1,38.1,40.2,30.1,23.5,11.5,1.6804915514592935,0.7488832896269212,0.0726971985342757,1.138482324829376,0.2946998469700616,0.530620089667805,1803]
["O00399","Dynactin subunit 6 [OS=Homo sapiens]",22,4,9,4,190,20.7,6.32,21.9,"cell cycle OR cell proliferation;cell organization and biogenesis","cytosol;cytoskeleton;other cell component","other molecular function","DCTN6","ENSG00000104671","Vasopressin-regulated water reabsorption; Amyotrophic lateral sclerosis; Huntington disease; Pathways of neurodegeneration; Salmonella infection","MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic","",1124.8,1101.7,1083.4,1212.3,1218,2029.8,0.7421134055290239,-0.4302884267842031,0.2312132917705069,0.6359872032244348,0.49183293060262945,0.3081823964996665,3436]
["O00400","Acetyl-coenzyme A transporter 1 [OS=Homo sapiens]",23,12,40,12,549,60.9,7.33,119.98,"transport;signal transduction","plasma membrane;other membranes;ER/Golgi","transporter activity","SLC33A1","ENSG00000169359","Glycosphingolipid biosynthesis; Metabolic pathways","Transport of vitamins, nucleosides, and related molecules; Defective SLC33A1 causes spastic paraplegia 42 (SPG42)","Ganglio sphingolipid metabolism",4138.2,4886.3,4616.4,4236.2,3712.8,4514.2,1.0944941908980035,0.13026429733760453,0.2884622337277656,0.5399110378193883,0.539087309208959,0.26834089188754606,3911]
["O00401","Neural Wiskott-Aldrich syndrome protein [OS=Homo sapiens]",2,1,1,1,505,54.8,7.93,1.92,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity","WASL","ENSG00000106299","Endocytosis; Adherens junction; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection","Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RHOJ GTPase cycle; RHOV GTPase cycle; NOSTRIN mediated eNOS trafficking; Nephrin family interactions; EPHB-mediated forward signaling; DCC mediated attractive signaling","Pathogenic Escherichia coli infection; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Chemokine signaling pathway; G13 signaling pathway",163.6,144.1,156,144.1,145.7,92,1.214510214772132,0.28037462397058804,0.2146647325450904,0.6682393003199993,0.4748742524733855,0.32342137708437096,3304]
["O00410","Importin-5 [OS=Homo sapiens]",59,46,321,43,1097,123.6,4.94,1059.57,"transport;other biological processes","nucleus;other cell component","enzyme regulator activity;other molecular function","IPO5","ENSG00000065150","Nucleocytoplasmic transport","vRNP Assembly","",32299.7,32261.5,31532.3,32169.4,31506.5,24107.6,1.0946647148951683,0.1304890540922729,0.3460659790765997,0.4608410930651056,0.5797378503485829,0.23676834416795273,4363]
["O00411","DNA-directed RNA polymerase, mitochondrial [OS=Homo sapiens]",19,16,52,16,1230,138.5,8.98,169.38,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","POLRMT","ENSG00000099821","","Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis","Mitochondrial gene expression",2771.4,2914,2609.7,3221.2,3059.9,4222.6,0.7897312375639058,-0.34056633805931263,0.12049116918674026,0.9190447814211142,0.36909889169567667,0.4328572588714643,2386]
["O00418","Eukaryotic elongation factor 2 kinase [OS=Homo sapiens]",16,11,19,11,725,82.1,5.33,36.59,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;other cell component","nucleic acid binding activity;kinase activity;other molecular function","EEF2K","ENSG00000103319","AMPK signaling pathway; Oxytocin signaling pathway","mTORC1-mediated signalling","Translation factors; AMP-activated protein kinase (AMPK) signaling; BDNF-TrkB signaling",1509.3,1683.1,1506.1,1695.3,1608.5,2592.4,0.7968691699738814,-0.327585212984473,0.28008659327143043,0.5527076787793812,0.5326965678430614,0.27352010135975696,3843]
["O00422","Histone deacetylase complex subunit SAP18 [OS=Homo sapiens]",52,8,41,8,153,17.6,9.35,77,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","SAP18","ENSG00000150459","Nucleocytoplasmic transport; mRNA surveillance pathway","Potential therapeutics for SARS; HDACs deacetylate histones; NoRC negatively regulates rRNA expression","Hedgehog signaling pathway Netpath",4533.2,4430.1,4448.7,4930.1,5002.2,4738.1,0.9142218344421421,-0.12938381951877695,0.007832225419195794,2.106114821600216,0.10640471299052427,0.9730391353826323,538]
["O00425","Insulin-like growth factor 2 mRNA-binding protein 3 [OS=Homo sapiens]",2,2,2,2,579,63.7,8.87,2.02,"protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","IGF2BP3","ENSG00000136231","","Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA","",167.9,146.3,149.3,160.9,155.1,86.3,1.1521252796420585,0.20429760088726337,0.45851404166063003,0.3386473598361614,0.6394350563819013,0.1942035576547818,5241]
["O00429","Dynamin-1-like protein [OS=Homo sapiens]",70,45,189,1,736,81.8,6.81,589.96,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","DNM1L","ENSG00000087470","Necroptosis; NOD-like receptor signaling pathway; TNF signaling pathway","Apoptotic execution phase","Synaptic vesicle pathway; CAMKK2 pathway",19778.9,19764.8,19224.3,18290.6,17781.6,15240.3,1.145295980511571,0.19572048429176547,0.06092979992368571,1.215170247974036,0.26571354871254105,0.5755863003843208,1676]
["O00429-2","Isoform 4 of Dynamin-1-like protein [OS=Homo sapiens]",71,45,192,1,725,80.5,6.71,609.4,"","","","DNM1L","","","","",396.9,373.4,399.4,402.7,419.6,447.6,0.9210961493030945,-0.1185763339207849,0.09733201824862091,1.0117442711263012,0.33367716762625244,0.47667350959686283,2132]
["O00442","RNA 3'-terminal phosphate cyclase [OS=Homo sapiens]",44,14,51,14,366,39.3,7.85,155.6,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","RTCA","ENSG00000137996","","","",4476.5,4616.8,4551.1,4173.4,3915.1,3798.1,1.1478808069590967,0.19897284398519005,0.007686179953636695,2.114289451779486,0.10639827515365645,0.9730654124293254,528]
["O00443","phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [OS=Homo sapiens]",16,23,31,23,1686,190.6,8.02,87.31,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","PIK3C2A","ENSG00000011405","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Salmonella infection","Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane","Glioblastoma signaling pathways; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; Osteoblast differentiation and related diseases; Insulin signaling; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)",2468.5,2537.5,2510.8,2998.7,3003.3,3676.6,0.7766412497675282,-0.3646797597055836,0.03330793526459144,1.4774522880829737,0.2028730823740824,0.6927755722466254,1200]
["O00459","Phosphatidylinositol 3-kinase regulatory subunit beta [OS=Homo sapiens]",6,3,5,3,728,81.5,6.43,10.37,"other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;cytosol;nucleus","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","PIK3R2","ENSG00000105647","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; Platinum drug resistance; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Phosphatidylinositol signaling system; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Osteoclast differentiation; Focal adhesion; Signaling pathways regulating pluripotency of stem cells; Platelet activation; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; TNF signaling pathway; Leukocyte transendothelial migration; Neurotrophin signaling pathway; Cholinergic synapse; Inflammatory mediator regulation of TRP channels; Regulation of actin cytoskeleton; Insulin signaling pathway; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Prolactin signaling pathway; Thyroid hormone signaling pathway; Regulation of lipolysis in adipocytes; Relaxin signaling pathway; GnRH secretion; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Aldosterone-regulated sodium reabsorption; Carbohydrate digestion and absorption; Alzheimer disease; Spinocerebellar ataxia; Prion disease; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection; Chagas disease; Amoebiasis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","Downstream TCR signaling; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOJ GTPase cycle; Nephrin family interactions; Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; RND2 GTPase cycle; RHOA GTPase cycle; G alpha (q) signalling events; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; Extra-nuclear estrogen signaling; RHOU GTPase cycle; PIP3 activates AKT signaling; Synthesis of PIPs at the plasma membrane; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Interleukin receptor SHC signaling; Regulation of signaling by CBL; RAF/MAP kinase cascade; PI3K Cascade; GPVI-mediated activation cascade; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; Costimulation by the CD28 family; CD28 dependent PI3K/Akt signaling; VEGFA-VEGFR2 Pathway; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; RND3 GTPase cycle; RND1 GTPase cycle","IL-5 signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase (AMPK) signaling; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL-6 signaling pathway; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Ebola virus pathway in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Modulators of TCR signaling and T cell activation; Orexin receptor pathway; Regulation of actin cytoskeleton; Alzheimer's disease; G13 signaling pathway; Interferon type I signaling pathways; Notch signaling pathway (Netpath); ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway",221.5,222.7,216.4,288,282.3,380.6,0.6947102744768116,-0.5255166605373025,0.038713714698025904,1.4121351548124603,0.21649467538475234,0.6645527805090318,1307]
["O00461","Golgi integral membrane protein 4 [OS=Homo sapiens]",38,23,53,23,696,81.8,4.77,156.08,"","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","GOLIM4","ENSG00000173905","","Intra-Golgi traffic","",3796.3,3861.3,4056.1,4137.1,4307.5,3796.1,0.9569469066311568,-0.06348921162307182,0.35830307048904547,0.445749470118189,0.5875784478807344,0.2309341423203924,4457]
["O00462","Beta-mannosidase [OS=Homo sapiens]",14,11,21,10,879,100.8,5.52,57.12,"protein metabolism;other metabolic processes","plasma membrane;other membranes;other cytoplasmic organelle","other molecular function","MANBA","ENSG00000109323","Other glycan degradation; Lysosome","Neutrophil degranulation; Lysosomal oligosaccharide catabolism","",1458.5,1455.6,1469.6,1318.6,1323.4,1890.2,0.9672344556727417,-0.04806245643887511,0.8071089840377452,0.09306781847433915,0.8785047750308086,0.05625587359510035,6715]
["O00463","TNF receptor-associated factor 5 [OS=Homo sapiens]",2,1,3,1,557,64.4,7.43,5.82,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton","signal transduction activity or receptor binding;other molecular function","TRAF5","ENSG00000082512","NF-kappa B signaling pathway; Necroptosis; NOD-like receptor signaling pathway; IL-17 signaling pathway; TNF signaling pathway; Shigellosis; Human cytomegalovirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Viral carcinogenesis; Small cell lung cancer","","RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Small cell lung cancer; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling",31.4,29.2,34.2,38.9,36.8,20,0.9905956112852665,-0.013631865587766363,0.963452463114136,0.016169708633357566,0.9779022431469546,0.009704557670285902,7201]
["O00469-1","procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 [OS=Homo sapiens]",4,2,2,2,737,84.6,6.71,7.23,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","other molecular function","PLOD2","ENSG00000152952","Lysine degradation; Metabolic pathways","Collagen biosynthesis and modifying enzymes","Clear cell renal cell carcinoma pathways; Type I collagen synthesis in the context of osteogenesis imperfecta",151.6,163.7,158.1,213.1,233.8,283.6,0.6480492813141683,-0.6258245669562462,0.015600961689712202,1.8068486296159068,0.14525787132497642,0.8378603244771864,785]
["O00470","Homeobox protein Meis1 [OS=Homo sapiens]",2,1,1,1,390,43,6.33,2.92,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MEIS1","ENSG00000143995","Signaling pathways regulating pluripotency of stem cells; Transcriptional misregulation in cancer","Activation of anterior HOX genes in hindbrain development during early embryogenesis","Mesodermal commitment pathway",29.8,25.5,27,53,61.9,52.2,0.4925194494314781,-1.0217473976395626,1.0857635488308323E-3,2.964264742536073,0.045347690162311736,1.3434448293383947,175]
["O00471","Exocyst complex component 5 [OS=Homo sapiens]",21,14,26,14,708,81.8,6.71,63.68,"cell organization and biogenesis;transport;other biological processes","cytosol;other cell component","other molecular function","EXOC5","ENSG00000070367","Salmonella infection","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium","Ciliary landscape",2159.3,2136.8,2160,2119.4,2100,3453.2,0.8414487918046034,-0.24905261900356201,0.41651949492837625,0.38036466690622045,0.6171378448067103,0.2096178204843887,4933]
["O00479","High mobility group nucleosome-binding domain-containing protein 4 [OS=Homo sapiens]",27,3,5,3,90,9.5,10.48,8.92,"cell organization and biogenesis","nucleus;other cell component","nucleic acid binding activity;other molecular function","HMGN4","ENSG00000182952","","","",1010.7,833.7,615.8,575.9,683.9,539,1.3676895708249943,0.45174081395697535,0.1455266662047417,0.8370574195683698,0.3986710657010709,0.3993852829289081,2668]
["O00481-1","Butyrophilin subfamily 3 member A1 [OS=Homo sapiens]",10,5,6,2,513,57.6,8.03,14.04,"cell cycle OR cell proliferation;signal transduction;other biological processes","plasma membrane;other membranes","signal transduction activity or receptor binding","BTN3A1","ENSG00000026950","","Butyrophilin (BTN) family interactions","",247.2,260.5,255.3,230.2,211.3,212.8,1.1661317438483876,0.22173078635998608,0.007302180483485894,2.136547437065103,0.10323334072301431,0.9861800182750724,517]
["O00483","Cytochrome c oxidase subunit NDUFA4 [OS=Homo sapiens]",56,5,23,5,81,9.4,9.38,59.42,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","NDUFA4","ENSG00000189043","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; Oxidative phosphorylation",4109.8,4059.4,4619.4,4209.6,5351,2755.8,1.0383391250690135,0.05427770973682751,0.8483920972807775,0.07140338556251874,0.90352583986962,0.04405942256921721,6863]
["O00487","26S proteasome non-ATPase regulatory subunit 14 [OS=Homo sapiens]",47,12,47,12,310,34.6,6.52,121.33,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PSMD14","ENSG00000115233","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection","Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; Metalloprotease DUBs","Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease",5496.9,5469.9,6002.1,5230.7,5249.7,4488.4,1.1336179252845922,0.18093447610209576,0.0938260842570402,1.0276764081658396,0.3287511264787665,0.4831327503723786,2086]
["O00499","Myc box-dependent-interacting protein 1 [OS=Homo sapiens]",4,2,6,1,593,64.7,5.06,19.85,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","BIN1","ENSG00000136717","Endocytosis; Fc gamma R-mediated phagocytosis","Clathrin-mediated endocytosis","VEGFA-VEGFR2 signaling pathway; IL-18 signaling pathway",42.1,52.2,40.9,58.4,55.3,50.5,0.823386114494519,-0.2803589754956202,0.0856558185012781,1.06724313057156,0.3158720370463379,0.5004888188368434,1982]
["O00505","Importin subunit alpha-4 [OS=Homo sapiens]",28,11,49,7,521,57.8,4.94,140.19,"cell organization and biogenesis;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","KPNA3","ENSG00000102753","Nucleocytoplasmic transport; Salmonella infection; Chemical carcinogenesis","ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways","",1041.4,886.2,1069.2,1016,1092.6,662.2,1.0815648910062077,0.11312022574777413,0.6291292400668249,0.20126012962254952,0.7608050323706855,0.11872662340556432,6044]
["O00506","serine/threonine-protein kinase 25 [OS=Homo sapiens]",23,7,35,2,426,48.1,6.74,85.36,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","kinase activity;other molecular function","STK25","ENSG00000115694","","","",68.1,71.3,62.1,65.7,75,246.5,0.5204028925619835,-0.9422991138592648,0.35214881916905394,0.4532737635522796,0.5839055624561287,0.2336573875120353,4408]
["O00507-1","Probable ubiquitin carboxyl-terminal hydrolase FAF-Y [OS=Homo sapiens]",9,21,47,1,2555,290.9,5.86,131.75,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","USP9Y","ENSG00000114374","","","",123.1,111.1,119.4,115,132.6,181.1,{"$f":"AVERAGE(S130:U130)/AVERAGE(V130:X130)","v":0.8248192209003966},{"$f":"LOG(Y130,2)","v":-0.27785014242554096},{"$f":"TTEST(V130:X130,S130:U130,2,2)","v":0.2805359817771488},0.5520114278656593,{"$f":"AA130*7309/AE130","v":0.5329964883829427},0.2732756522885018,3847]
["O00512","B-cell CLL/lymphoma 9 protein [OS=Homo sapiens]",1,1,1,1,1426,149.2,8.91,0,"cell-cell signaling;developmental processes;signal transduction;other biological processes","ER/Golgi;nucleus","other molecular function","BCL9","ENSG00000116128","","Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex","Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; 1q21.1 copy number variation syndrome",20.2,14.9,20.8,15.7,17.8,45,0.7121019108280255,-0.48984437093579913,0.4773663134168789,{"$f":"-LOG10(AA131)","v":0.32114823135638976},0.6521626887409285,{"$f":"-LOG10(AC131)","v":0.18564405149364527},5350]
["O00519","Fatty-acid amide hydrolase 1 [OS=Homo sapiens]",25,10,26,10,579,63,7.66,84.13,"other metabolic processes","other membranes;cytoskeleton;ER/Golgi","other molecular function","FAAH","ENSG00000117480","Retrograde endocannabinoid signaling","Arachidonic acid metabolism","Cannabinoid receptor signaling",2187.9,2154.8,2151.9,2007.5,2099.8,2778.6,0.9431737318288098,-0.08440455626438068,0.620435589047365,0.20730329840906797,0.7537838630896261,0.12275316410868083,6016]
["O00522","Krev interaction trapped protein 1 [OS=Homo sapiens]",9,6,11,6,736,84.3,8.41,34.25,"developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","KRIT1","ENSG00000001631","Rap1 signaling pathway","","",993.8,1077.9,994.9,899.8,920,1279.5,0.9894492304713965,-0.015302411693649601,0.9354465328962389,0.02898103032508046,0.958527787598291,0.018395292461790735,7133]
["O00534","von Willebrand factor A domain-containing protein 5A [OS=Homo sapiens]",5,4,4,4,786,86.4,6.58,7.8,"","nucleus","","VWA5A","ENSG00000110002","","","",499.3,526,489.1,451.6,417.8,420.5,1.1740444995736103,0.23148709166558615,0.008374306957295508,2.07705112424054,0.10969141496572199,0.9598273612941457,558]
["O00541-1","Pescadillo homolog [OS=Homo sapiens]",32,18,54,18,588,68,7.33,167.5,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PES1","ENSG00000100029","","Major pathway of rRNA processing in the nucleolus and cytosol","",6592.5,6920.2,6531.8,8828.2,8283.3,8207.2,0.7916875668971944,-0.3369969002111412,1.567687548392758E-3,2.8047404910971117,0.05329408507536124,1.2733209891287438,215]
["O00555-1","Voltage-dependent P/Q-type calcium channel subunit alpha-1A [OS=Homo sapiens]",1,1,2,1,2505,282.2,8.84,2.07,"","","","","","","","",824.6,881.5,973.8,536.3,571.9,221.5,2.015417011355945,1.0110783786887718,0.01968311232328838,1.7059062291790283,0.1614633759493993,0.7919259713319301,891]
["O00559","Receptor-binding cancer antigen expressed on SiSo cells [OS=Homo sapiens]",8,1,1,1,213,24.4,6.29,3.29,"other biological processes","other membranes;ER/Golgi;other cell component","enzyme regulator activity","EBAG9","ENSG00000147654","Estrogen signaling pathway","Estrogen-dependent gene expression","",46.6,51,46.7,42.6,51.4,74.3,0.857397504456328,-0.22196387683875088,0.4497131685631658,0.34706439517481125,0.6347921106659287,0.19736847938969154,5178]
["O00560-1","Syntenin-1 [OS=Homo sapiens]",23,4,13,4,298,32.4,7.53,47.62,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","SDCBP","ENSG00000137575; ENSPPAG00000038846; ENSPTRG00000020277","","Neutrophil degranulation; Ephrin signaling; Neurofascin interactions; Regulation of necroptotic cell death","Ectoderm differentiation; Ectoderm differentiation; VEGFA-VEGFR2 signaling pathway",961.8,995.4,1070.4,813.2,835.5,1467.3,0.9716302952503207,-0.0415206212515752,0.8984545189832431,0.046503902588998676,0.9339786771794232,0.029663038640379908,7031]
["O00566","U3 small nucleolar ribonucleoprotein protein Mpp10 [OS=Homo sapiens]",27,15,32,15,681,78.8,4.86,83.9,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","MPHOSPH10","ENSG00000124383","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",2221.4,2415.2,2430,3835.5,3701,2119.3,0.7318502868742103,-0.45037954538758485,0.19496980976171183,0.7100326320680957,0.45296705007894206,0.3439333884713909,3146]
["O00567","Nucleolar protein 56 [OS=Homo sapiens]",67,29,161,29,594,66,9.19,489.84,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NOP56","ENSG00000101361","Ribosome biogenesis in eukaryotes; Spinocerebellar ataxia","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; Association of TriC/CCT with target proteins during biosynthesis","",17163.2,18065.4,18094.9,17149.4,16242.9,16429.3,1.0702887904041622,0.09800012398106488,0.047245482302823494,1.325639713181325,0.23716842730174237,0.6249431262743704,1456]
["O00571","ATP-dependent RNA helicase DDX3X [OS=Homo sapiens]",58,34,224,33,662,73.2,7.18,686.69,"cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function","DDX3X","ENSG00000215301","RIG-I-like receptor signaling pathway; Hepatitis B; Viral carcinogenesis","Neutrophil degranulation","Novel intracellular components of RIG-I-like receptor (RLR) pathway; Hepatitis B infection",28502.1,27669.2,27766.3,33554.5,33132.1,22239.6,0.9439017972206166,-0.0832913243177511,0.6774116454198598,0.1691473416475266,0.7916855958384641,0.10144725667046811,6254]
["O00592","Podocalyxin [OS=Homo sapiens]",13,7,19,7,558,58.6,5.49,54.88,"cell adhesion;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","","PODXL","ENSG00000128567","Salmonella infection","","Primary focal segmental glomerulosclerosis (FSGS); Ectoderm differentiation; Hepatitis C and hepatocellular carcinoma; Nephrotic syndrome; Malignant pleural mesothelioma",2996.6,2826.1,2787.6,2436.9,2684,2327.5,1.1559932334461094,0.2091329531134077,0.03494500278677388,1.4566149205562902,0.20614449182286543,0.6858282650483806,1239]
["O00625","Pirin [OS=Homo sapiens]",10,3,9,3,290,32.1,6.92,14.48,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PIR","ENSG00000087842","","Digestion","",1089.7,1104.6,1114.9,1135.8,1048.9,1355.1,0.9348550765579979,-0.09718536254624413,0.4476805863406482,0.34903173837942686,0.6335135344750819,0.1982441023510933,5165]
["O00629","Importin subunit alpha-3 [OS=Homo sapiens]",41,13,91,9,521,57.9,4.96,346.45,"transport","other membranes;cytosol;nucleus","other molecular function","KPNA4","ENSG00000186432","Nucleocytoplasmic transport; Salmonella infection; Chemical carcinogenesis","ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways","Leptin signaling pathway",10750,9967.8,10569.4,9700.6,10471,6426,1.1763166601497879,0.23427648069456275,0.2833147122623686,0.5477308723963966,0.5352151025912774,0.27147164023366854,3869]
["O00635","E3 ubiquitin-protein ligase TRIM38 [OS=Homo sapiens]",8,4,9,4,465,53.4,7.02,15.62,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","TRIM38","ENSG00000112343","","Interferon gamma signaling","",798.6,820.7,744.3,762.7,771.6,2036.2,0.6619801148298559,-0.5951402142102044,0.3960684070549199,0.40222979831503,0.6041035031645262,0.21888864581231202,4792]
["O00743","Serine/threonine-protein phosphatase 6 catalytic subunit [OS=Homo sapiens]",33,9,31,9,305,35.1,5.69,93.67,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport","cytosol;mitochondrion;nucleus","other molecular function","PPP6C","ENSG00000119414","","Telomere Extension By Telomerase; COPII-mediated vesicle transport","",3781.4,3917.9,3818.2,3754.2,3731.2,3826,1.0182205562529836,0.026050096725840244,0.239649924800647,0.6204227029487182,0.4991739242997803,0.30174810928015133,3509]
["O00746","Nucleoside diphosphate kinase, mitochondrial [OS=Homo sapiens]",16,2,4,2,187,20.6,10.29,10.56,"other metabolic processes;transport","other membranes;mitochondrion","kinase activity;other molecular function","NME4","ENSG00000103202","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors","Interconversion of nucleotide di- and triphosphates","Pyrimidine metabolism",466.1,414.3,470.5,361.1,418.5,419,1.1270649090605709,0.17257060449257094,0.12642358778516058,0.8981718889553549,0.37562195248851166,0.42524903417476106,2460]
["O00750","Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [OS=Homo sapiens]",2,3,3,3,1634,184.7,7.3,8.8,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","PIK3C2B","ENSG00000133056","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Salmonella infection","Synthesis of PIPs at the plasma membrane","Glioblastoma signaling pathways; S1P receptor signal transduction; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; EGF/EGFR signaling pathway; Osteoblast differentiation and related diseases; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)",202.5,167.5,182.2,200.9,207.5,222.7,0.8749801933132627,-0.19267773546485556,0.09400407046728373,1.026853340621512,0.3290592677420387,0.4827258730677634,2088]
["O00754","Lysosomal alpha-mannosidase [OS=Homo sapiens]",11,10,16,10,1011,113.7,7.28,49.54,"protein metabolism;other metabolic processes","non-structural extracellular;other membranes;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MAN2B1","ENSG00000104774","Other glycan degradation; Lysosome","Neutrophil degranulation; Lysosomal oligosaccharide catabolism","",2132.8,2079.6,2026,1786.6,1800,4479.4,0.7734192908504836,-0.3706773458956026,0.5338339953089274,0.2725937731768882,0.689606339998754,0.16139875441388732,5658]
["O00762","Ubiquitin-conjugating enzyme E2 C [OS=Homo sapiens]",6,1,1,1,179,19.6,7.37,0,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","UBE2C","ENSG00000175063","Ubiquitin mediated proteolysis","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Gastric cancer network 1; Gastric cancer network 2",17.6,16.8,26.9,49.4,62.7,137.8,0.2452981192476991,-2.0273919223959225,0.08584283258157108,1.0662959602610078,0.31560626928506186,0.5008543784383293,1988]
["O00763","Acetyl-CoA carboxylase 2 [OS=Homo sapiens]",5,9,16,5,2458,276.4,6.49,54.84,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus","other molecular function","ACACB","ENSG00000076555","Fatty acid biosynthesis; Pyruvate metabolism; Propanoate metabolism; Metabolic pathways; AMPK signaling pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Glucagon signaling pathway; Insulin resistance; Alcoholic liver disease","ChREBP activates metabolic gene expression; Biotin transport and metabolism; Carnitine metabolism; Activation of gene expression by SREBF (SREBP)","AMP-activated protein kinase (AMPK) signaling; Leptin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; IL-18 signaling pathway; 7q11.23 copy number variation syndrome",503.2,532.4,506.1,550.4,556.6,808,0.8050652741514359,-0.3128223341733707,0.21864661331850876,0.6602572451815734,0.4791868356056913,0.3194951215501682,3335]
["O00764-1","Pyridoxal kinase [OS=Homo sapiens]",57,17,137,17,312,35.1,6.13,367.38,"other metabolic processes","non-structural extracellular;nucleus;other cell component","kinase activity;other molecular function","HEL-S-1a; PDXK","ENSG00000160209","Vitamin B6 metabolism; Metabolic pathways; Biosynthesis of cofactors","Neutrophil degranulation; Vitamins B6 activation to pyridoxal phosphate","",12100.6,11989.1,11335,10624.9,10519.4,8501,1.1949516449487776,0.25695223912311865,0.05789176209531532,1.2373832312826456,0.26151476461969075,0.5825037866749262,1618]
["O00767","acyl-CoA desaturase [OS=Homo sapiens]",13,5,23,5,359,41.5,9,75.05,"other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","SCD","ENSG00000099194","Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; AMPK signaling pathway; Alcoholic liver disease","Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis","Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Adipogenesis; Liver X receptor pathway; Nuclear receptors meta-pathway; Fatty acid biosynthesis; Angiopoietin-like protein 8 regulatory pathway; PPAR signaling pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways",3089.4,2830.2,2395.7,4986.8,6148,2671.5,0.6022830157247054,-0.7314865191396748,0.15374079948842084,0.8132108648271343,0.40965785762335694,0.38757871054769083,2743]
["O14492","SH2B adapter protein 2 [OS=Homo sapiens]",13,4,8,4,632,67.7,6.27,21.53,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;other molecular function","SH2B2","ENSG00000160999","Neurotrophin signaling pathway; Insulin signaling pathway","Regulation of KIT signaling; Factors involved in megakaryocyte development and platelet production","Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; Insulin signaling",97.7,101.1,108.1,120.6,118,143.7,0.8027726916034529,-0.3169365543681637,0.044953036054522326,1.3472409714013036,0.23203512748764382,0.6344462628710809,1416]
["O14494","Phospholipid phosphatase 1 [OS=Homo sapiens]",4,1,2,1,284,32.1,7.97,6.94,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","PLPP1","ENSG00000067113","Glycerolipid metabolism; Glycerophospholipid metabolism; Ether lipid metabolism; Sphingolipid metabolism; Metabolic pathways; Phospholipase D signaling pathway; Fc gamma R-mediated phagocytosis; Fat digestion and absorption; Choline metabolism in cancer","Sphingolipid de novo biosynthesis","Androgen receptor signaling pathway; Androgen receptor signaling pathway; Sphingolipid pathway; Triacylglyceride synthesis; Androgen receptor signaling pathway",353.4,377.6,314.9,358.4,327.4,393,0.9695031516499817,-0.04468250665079875,0.6982129317672469,0.15601211177628455,0.8059441437597611,0.09369505608262989,6332]
["O14497","AT-rich interactive domain-containing protein 1A [OS=Homo sapiens]",21,40,81,38,2285,241.9,6.7,259.41,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ARID1A","ENSG00000117713","Thermogenesis; Hepatocellular carcinoma","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines","Pathways affected in adenoid cystic carcinoma; Tumor suppressor activity of SMARCB1; Thermogenesis",7453,7436.9,7126.6,8249.5,8664.5,9550.9,0.8319132133505133,-0.2654950631550006,0.020413553307753796,1.690081392754074,0.16359940912979443,0.7862182691985173,912]
["O14523","Phospholipid transfer protein C2CD2L [OS=Homo sapiens]",21,11,23,11,706,76.1,7.69,62.31,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","transporter activity;other molecular function","C2CD2L","ENSG00000172375","","","",1282.2,1245.3,1173.1,958.5,1110.6,1685.9,0.9855126498002662,-0.021053705417701452,0.9393190117402661,0.02718688748953646,0.9612829259044532,0.017148771462326653,7142]
["O14524-1","Nuclear envelope integral membrane protein 1 [OS=Homo sapiens]",8,4,9,4,444,50.6,6.93,22.32,"cell organization and biogenesis","other membranes;nucleus","","NEMP1","ENSG00000166881","","","",1478.1,1427.9,1328.3,1438.4,1364.9,1897.1,0.9008382265339121,-0.1506600462649831,0.4180139279592511,0.37880924756689277,0.6174744946350376,0.20938097664000288,4948]
["O14526-1","F-BAR domain only protein 1 [OS=Homo sapiens]",4,4,4,4,889,96.8,6.96,10.43,"cell organization and biogenesis;transport","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","FCHO1","ENSG00000130475","","Cargo recognition for clathrin-mediated endocytosis","",150.3,161.1,145.4,185.4,176.8,409.7,0.591786500842078,-0.7568513070921135,0.24108839394304302,0.6178236961667825,0.4998908003772202,0.301124855610227,3525]
["O14530","Thioredoxin domain-containing protein 9 [OS=Homo sapiens]",33,6,14,6,226,26.5,5.88,40.52,"","cytosol;cytoskeleton;nucleus;other cell component","","TXNDC9","ENSG00000115514","","","",1096.1,1130.5,1251,1868.3,1816.3,1616,0.6560766705655964,-0.6080636736700386,2.5209645199731068E-3,2.5984332665362984,0.06397822804334527,1.1939677924115564,288]
["O14531","dihydropyrimidinase-related protein 4 [OS=Homo sapiens]",11,2,16,2,572,61.8,7.09,35.54,"cell organization and biogenesis;developmental processes;other biological processes","cytosol","cytoskeletal activity;other molecular function","DPYSL4","ENSG00000151640","","CRMPs in Sema3A signaling","",936.9,1001.8,851.3,791.6,747,1400.1,0.9493993942899922,-0.07491296554881781,0.8290757528843928,0.08140578602796997,0.8931045951115737,0.049097676139752855,6785]
["O14545","TRAF-type zinc finger domain-containing protein 1 [OS=Homo sapiens]",2,1,1,1,582,64.8,5.29,1.98,"other biological processes","","other molecular function","TRAFD1","ENSG00000135148","","","Regulation of toll-like receptor signaling pathway",106.9,73.1,100.1,121.2,127,28.6,1.0119219653179192,0.017098040437781944,0.9753836215128406,0.0108245412873229,0.985087590111559,0.006525152029403452,7237]
["O14548","Cytochrome c oxidase subunit 7A-related protein, mitochondrial [OS=Homo sapiens]",11,1,1,1,114,12.6,9.42,3.72,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion;nucleus","transporter activity","COX7A2L","ENSG00000115944","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease",72.1,97.6,83.2,131,132,109,0.6798387096774193,-0.5567355843321553,0.019584822580626257,1.7080803583823398,0.16101852445646492,0.7931241574685806,889]
["O14561","Acyl carrier protein, mitochondrial [OS=Homo sapiens]",13,2,3,2,156,17.4,4.93,8.5,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;nucleus","other molecular function","NDUFAB1","ENSG00000004779","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Glyoxylate metabolism and glycine degradation; Mitochondrial Fatty Acid Beta-Oxidation; Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",250.3,199.4,249.5,237.4,356.7,597,0.5870204013097138,-0.7685174512506877,0.20046149631923862,0.6979690322304292,0.4591579682222861,0.3380378745399667,3191]
["O14562","Ubiquitin domain-containing protein UBFD1 [OS=Homo sapiens]",19,4,13,4,309,33.4,5.77,35.8,"","","","UBFD1","ENSG00000103353","","","",1310.6,1327,1667.2,1890.3,1816.8,1556.1,0.8179054567563461,-0.28999400593997554,0.10708230164705305,0.9702823025778241,0.34785090788369366,0.4586068588052136,2250]
["O14576-1","cytoplasmic dynein 1 intermediate chain 1 [OS=Homo sapiens]",6,3,4,3,645,72.9,5.12,8.9,"transport;other biological processes","cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","DNCI1; DYNC1I1","ENSG00000158560; ENSGGOG00000000228; ENSPTRG00000019422","Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection","Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Intraflagellar transport proteins binding to dynein",187.9,234.2,215.8,227.8,215.2,327.7,0.827689113792656,-0.27283911244255954,0.30930474315592266,0.5096134200852479,0.5579240789058832,0.25342489488951775,4052]
["O14578-4","Isoform 4 of Citron Rho-interacting kinase [OS=Homo sapiens]",5,9,11,9,2069,236.5,6.67,18.9,"","","","CIT","","","","",736.4,700.4,774.5,653.9,668.8,616.2,1.1404920315642892,0.1896563668053823,0.026649407733127774,1.5743124384607734,0.18497675320173873,0.7328828477622868,1053]
["O14579-1","coatomer subunit epsilon [OS=Homo sapiens]",36,11,48,11,308,34.5,5.12,138.59,"transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","COPE","ENSG00000105669; ENSPTRG00000010723","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport","",5958.2,6180.7,6085.5,5904.8,5629.1,4351.1,1.1472710103871575,0.19820622758592665,0.18167387148979766,0.7407075288491697,0.43954131966862997,0.3570002922384771,3021]
["O14593","DNA-binding protein RFXANK [OS=Homo sapiens]",4,1,1,1,260,28.1,4.55,0,"signal transduction;other biological processes","non-structural extracellular;cytosol;nucleus","nucleic acid binding activity;other molecular function","RFXANK","ENSG00000064490","Antigen processing and presentation; Tuberculosis; Primary immunodeficiency","","",67.1,59.9,61,97.1,92.3,180.7,0.5079708186976493,-0.9771824737352208,0.1026565366951564,0.9886133915417875,0.3426103318287206,0.4651995444979329,2190]
["O14617-5","Isoform 5 of AP-3 complex subunit delta-1 [OS=Homo sapiens]",36,40,125,40,1215,136.6,7.64,411.02,"","","","AP3D1","","","","",12749,12979.2,12629,12059.2,12303.9,11535.3,1.0684933033227109,0.095577866075973,0.030133931340215747,1.5209442055989835,0.19405189794329242,0.712082105244152,1135]
["O14618","copper chaperone for superoxide dismutase [OS=Homo sapiens]",16,5,19,5,274,29,5.58,36.89,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","CCS","ENSG00000173992","Amyotrophic lateral sclerosis; Pathways of neurodegeneration","Detoxification of Reactive Oxygen Species","Amyotrophic lateral sclerosis (ALS); Copper homeostasis",1953.5,1807.9,1750.6,1892.3,1917,3252.6,0.7805264872059927,-0.3574805039239656,0.31812488706610376,0.4974023544930809,0.5628600337850768,0.2495995875856941,4131]
["O14628-1","Zinc finger protein 195 [OS=Homo sapiens]",7,3,4,1,629,72.3,8.09,5.49,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF195","ENSG00000005801","Herpes simplex virus 1 infection","Generic Transcription Pathway","",23.4,23.4,25.6,25.6,36.6,9.4,1.0111731843575418,0.01603010981894876,0.974796737813426,0.011085932864414876,0.9847670154358439,0.006666506435498205,7235]
["O14639-1","Actin-binding LIM protein 1 [OS=Homo sapiens]",7,5,6,5,778,87.6,8.59,12.99,"cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ABLIM1","ENSG00000099204","Axon guidance","DCC mediated attractive signaling","Male infertility",728.9,679.6,705,767.6,728.4,1006,0.8447242206235012,-0.24344767713502707,0.21468269132731696,0.6682029689035585,0.47477028469330096,0.3235164708412446,3305]
["O14641","Segment polarity protein dishevelled homolog DVL-2 [OS=Homo sapiens]",6,4,6,2,736,78.9,6.02,11.66,"cell-cell signaling;cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","DVL2","ENSG00000004975","mTOR signaling pathway; Wnt signaling pathway; Notch signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer","RHO GTPases Activate Formins; Asymmetric localization of PCP proteins; Degradation of DVL; Cargo recognition for clathrin-mediated endocytosis; WNT mediated activation of DVL; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Negative regulation of TCF-dependent signaling by DVL-interacting proteins; WNT5:FZD7-mediated leishmania damping; Signaling by Hippo; WNT5A-dependent internalization of FZD4","Alzheimer's disease and miRNA effects; Neural crest differentiation; Notch signaling; Wnt signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Type 2 papillary renal cell carcinoma; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Malignant pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)",186.6,197.7,178.7,252.2,264.8,468.8,0.5711097585717184,-0.8081600587036387,0.11590439044510209,0.9359001126993305,0.36233754908607835,0.44088665764117885,2338]
["O14646","Chromodomain-helicase-DNA-binding protein 1 [OS=Homo sapiens]",13,18,26,15,1710,196.6,7.14,58.47,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CHD1","ENSG00000153922","","Estrogen-dependent gene expression","",2167.6,2085,2036.6,2481.4,2504.8,2489.5,0.8412857658814559,-0.24933216005241354,5.2465657688787436E-4,3.280124878623023,0.03277534120062798,1.4844527784852115,117]
["O14647","Chromodomain-helicase-DNA-binding protein 2 [OS=Homo sapiens]",11,17,26,14,1828,211.2,8.1,66.08,"cell organization and biogenesis;stress response;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","CHD2","ENSG00000173575","","","Prion disease pathway; Male infertility",1477.5,1427,1385.3,1564.8,1646.3,1463,0.9177809631800774,-0.1237782125330478,0.09704777081908376,1.01301443587675,0.33317151569595266,0.47733213543109976,2129]
["O14653-1","Golgi SNAP receptor complex member 2 [OS=Homo sapiens]",21,4,7,4,212,24.8,8.06,14.57,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","other molecular function","GOSR2","ENSG00000108433","SNARE interactions in vesicular transport","COPI-mediated anterograde transport; Intra-Golgi traffic; COPII-mediated vesicle transport; XBP1(S) activates chaperone genes; Cargo concentration in the ER","",608.1,577.5,608.6,641.8,730.6,596,0.9115017272912009,-0.13368270472049676,0.22802520925817774,0.6420171370499524,0.48789117519555647,0.311677037182947,3416]
["O14656","Torsin-1A [OS=Homo sapiens]",20,6,14,6,332,37.8,6.99,37.88,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","TOR1A","ENSG00000136827","","Cargo recognition for clathrin-mediated endocytosis","",1324.4,1365.9,1296,1348,1279,1088.1,1.0729993809049556,0.10164924369405459,0.32341788063567006,0.49023597315337164,0.5671452230244992,0.2463057215608667,4168]
["O14662-2","Isoform A of Syntaxin-16 [OS=Homo sapiens]",24,7,16,7,304,34.8,6.2,46.86,"","","","STX16","","","","",1096.3,944.7,1044.9,834.2,976.3,1727.1,0.8723145635459069,-0.1970796187928736,0.6199543564514305,0.20764028384202923,0.7537003312214746,0.12280129387292682,6012]
["O14672","Disintegrin and metalloproteinase domain-containing protein 10 [OS=Homo sapiens]",38,25,56,25,748,84.1,7.77,170.99,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ADAM10","ENSG00000137845","Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection","Amyloid fiber formation; Collagen degradation; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; NOTCH3 Activation and Transmission of Signal to the Nucleus; Neutrophil degranulation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant; Signaling by EGFR; EPH-ephrin mediated repulsion of cells; NOTCH4 Activation and Transmission of Signal to the Nucleus","Alzheimer's disease and miRNA effects; Copper homeostasis; Canonical and non-canonical Notch signaling; VEGFA-VEGFR2 signaling pathway; 3q29 copy number variation syndrome; Interactions of natural killer cells in pancreatic cancer; Alzheimer's disease; Hypertrophy model",4102.6,4253.5,4105.5,4325.1,4485.8,5928.8,0.8454446155620535,-0.24221784701863067,0.21242326670529305,0.6727979167415926,0.47248985281466427,0.32560751395666265,3286]
["O14681","Etoposide-induced protein 2.4 homolog [OS=Homo sapiens]",2,1,3,1,340,38.9,9.72,5.03,"other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus","other molecular function","EI24","ENSG00000149547","p53 signaling pathway","","miRNA regulation of p53 pathway in prostate cancer; Genotoxicity pathway",425.7,465.6,400.8,380.7,391.1,705.4,0.8746953696181967,-0.19314743824259864,0.5990207867097979,0.22255810683151153,0.7383208988300021,0.13175483831180118,5930]
["O14683","Tumor protein p53-inducible protein 11 [OS=Homo sapiens]",8,1,2,1,189,21,9.55,8.88,"other biological processes","other membranes","","TP53I11","ENSG00000175274","","","",144.4,159.7,163.7,133.4,139.1,273.4,0.8569335043048177,-0.22274483539398995,0.6026054522129523,0.21996694326457442,0.7403669944905813,0.13055295030556655,5949]
["O14686-1","Histone-lysine N-methyltransferase 2D [OS=Homo sapiens]",4,13,15,12,5537,593,5.58,42.08,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","KMT2D","ENSG00000167548","Lysine degradation; Metabolic pathways; Cushing syndrome","Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","Histone modifications; 16p11.2 proximal deletion syndrome",570.7,607.4,620.4,707.1,728.6,1326.8,0.6510407239819004,-0.6191803050307766,0.18968596403292234,0.7219648038955977,0.4483876814736835,0.34834632725791204,3092]
["O14717-1","tRNA (cytosine(38)-C(5))-methyltransferase [OS=Homo sapiens]",2,1,2,1,391,44.6,6.09,5.15,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DNMT2; TRDMT1","ENSG00000107614","","tRNA modification in the nucleus and cytosol","",372.4,302.6,363.8,326.9,433.1,151.6,1.1395348837209303,0.18844508941311033,0.6439550973291532,0.1911444147241205,0.7699440219824606,0.11354084862992772,6113]
["O14730","serine/threonine-protein kinase RIO3 [OS=Homo sapiens]",12,6,7,6,519,59.1,5.76,17.24,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;other cell component","kinase activity;other molecular function","RIOK3","ENSG00000101782","","Major pathway of rRNA processing in the nucleolus and cytosol","",779.5,788.4,712,776.7,803.3,958,0.8983057525610717,-0.15472152227496083,0.23411957275025433,0.6305622771102928,0.4938470295040718,0.30640755417414545,3465]
["O14732-1","inositol monophosphatase 2 [OS=Homo sapiens]",7,2,2,2,288,31.3,6.61,5.48,"other metabolic processes;signal transduction","cytosol;other cell component","other molecular function","IMPA2","ENSG00000141401","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of IP2, IP, and Ins in the cytosol","",155,145.5,147.6,166.1,172.4,249.5,0.7620748299319728,-0.3919954285712214,0.15880675883606807,0.7991310178866073,0.41543256991153243,0.3814994577807974,2794]
["O14733","dual specificity mitogen-activated protein kinase kinase 7 [OS=Homo sapiens]",18,6,10,6,419,47.5,9.16,26.35,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","MAP2K7","ENSG00000076984","MAPK signaling pathway; ErbB signaling pathway; Protein processing in endoplasmic reticulum; Osteoclast differentiation; Tight junction; Toll-like receptor signaling pathway; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; TNF signaling pathway; Neurotrophin signaling pathway; GnRH signaling pathway; Relaxin signaling pathway; Alcoholic liver disease; Alzheimer disease; Huntington disease; Pathways of neurodegeneration; Salmonella infection; Yersinia infection; Hepatitis B; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Chemical carcinogenesis; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; Uptake and function of anthrax toxins","Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; MAPK signaling pathway; ERK pathway in Huntington's disease; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; MAPK cascade; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; IL-18 signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Malignant pleural mesothelioma; Alzheimer's disease; ErbB signaling pathway; Toll-like receptor signaling pathway",1265.6,1088,1054.9,1208.7,1302.9,933.7,0.9893187821089601,-0.01549262823713052,0.9286142392914714,0.03216466118427597,0.9538000948540422,0.020542638712190447,7116]
["O14734","Acyl-coenzyme A thioesterase 8 [OS=Homo sapiens]",20,5,8,5,319,35.9,7.56,23.55,"cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle","other molecular function","ACOT8","ENSG00000101473","Primary bile acid biosynthesis; Metabolic pathways; Peroxisome","Peroxisomal protein import; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of pristanoyl-CoA; Beta-oxidation of very long chain fatty acids","",694.7,712.5,692.3,571,491.8,526,1.3214375629405841,0.4021082601940056,0.00202239509766332,2.694133996137201,0.05936419987478396,1.2264753813489646,249]
["O14735","CDP-diacylglycerol--inositol 3-phosphatidyltransferase [OS=Homo sapiens]",25,5,18,5,213,23.5,8.03,34.86,"other metabolic processes","plasma membrane;other membranes;ER/Golgi","other molecular function","CDIPT","ENSG00000103502","Inositol phosphate metabolism; Glycerophospholipid metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of PI","Glycerolipids and glycerophospholipids; 16p11.2 proximal deletion syndrome",1681.6,1438.2,1657.4,1314.8,1364.5,1431.9,1.1619964973730297,0.21660572000735048,0.05840511868126331,1.2335490892298808,0.2615704733096529,0.5824112817637501,1632]
["O14744","Protein arginine N-methyltransferase 5 [OS=Homo sapiens]",37,21,49,21,637,72.6,6.29,162.74,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","PRMT5","ENSG00000100462","","snRNP Assembly; RMTs methylate histone arginines; Regulation of TP53 Activity through Methylation","Transcription co-factors SKI and SKIL protein partners; Nitric oxide metabolism in cystic fibrosis",6646.7,6790.8,6872.1,6239.4,6233.2,6015.1,1.0985466012538065,0.13559607137406157,3.5673517164607504E-3,2.44765407008753,0.07535772744396423,1.1228722069963337,346]
["O14745","Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [OS=Homo sapiens]",69,21,108,21,358,38.8,5.77,328.28,"cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;transporter activity;cytoskeletal activity;other molecular function","SLC9A3R1","ENSG00000109062","Tight junction; Parathyroid hormone synthesis, secretion and action; Pathogenic Escherichia coli infection; Human papillomavirus infection","","",12181.8,11473.5,13639,14842,14667.6,15476.2,0.8290238252959823,-0.2705145309921033,0.019897804033203795,1.701194850669999,0.16159227742076282,0.7915793982253508,900]
["O14757","Serine/threonine-protein kinase Chk1 [OS=Homo sapiens]",4,2,2,2,476,54.4,8.25,5.21,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","CHEK1","ENSG00000149554","Cell cycle; p53 signaling pathway; Cellular senescence; Human T-cell leukemia virus 1 infection; Human immunodeficiency virus 1 infection; Viral carcinogenesis","Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Transcriptional Regulation by E2F6; Signaling by SCF-KIT; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex","miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; ATR signaling; ATM signaling in development and disease ; DNA repair pathways, full network; DNA damage response",171.4,219.9,224.2,468.5,406.6,199.1,0.5729845466393595,-0.8034318647837144,0.1399916996000987,0.8538977137841991,0.3935382047604313,0.40501309987104417,2600]
["O14772","fucose-1-phosphate guanylyltransferase [OS=Homo sapiens]",3,1,1,1,594,66.6,6.48,3.55,"","","other molecular function","FPGT","ENSG00000254685","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars","","",33.2,40.7,40.7,39.5,25.4,45,1.042766151046406,0.060415657807673884,0.8172598465398191,0.08763983823349338,0.8853345514094468,0.05289258650481503,6747]
["O14773","Tripeptidyl-peptidase 1 [OS=Homo sapiens]",32,10,45,10,563,61.2,6.48,142.15,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","TPP1","ENSG00000166340","Lysosome","XBP1(S) activates chaperone genes","VEGFA-VEGFR2 signaling pathway",5801.6,5529.8,5794.5,5407.2,5617.3,6027.4,{"$f":"AVERAGE(S194:U194)/AVERAGE(V194:X194)","v":1.004339692350999},{"$f":"LOG(Y194,2)","v":0.006247306722545569},{"$f":"TTEST(V194:X194,S194:U194,2,2)","v":0.909097615904854},0.04138948116452756,{"$f":"AA194*7309/AE194","v":0.9410274004600734},0.026397730775333965,7061]
["O14776-1","Transcription elongation regulator 1 [OS=Homo sapiens]",25,33,92,33,1098,123.8,8.65,229.28,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","TCERG1","ENSG00000113649; ENSGGOG00000003329; ENSPTRG00000017375","Spliceosome","","",12380.8,12718,12397.1,13546.6,13575.3,13963.2,0.9126398621398024,-0.13188242592139318,2.3185099936440206E-3,{"$f":"-LOG10(AA195)","v":2.634791027792719},0.060738313776143894,{"$f":"-LOG10(AC195)","v":1.2165372691823437},279]
["O14777","Kinetochore protein NDC80 homolog [OS=Homo sapiens]",29,18,37,18,642,73.9,5.6,94.67,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","NDC80","ENSG00000080986","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",4669.1,4436.4,4595.6,5123.2,5579.2,3890,0.9389202598612978,-0.09092545627091755,0.5908916409103886,0.2284921537539095,0.7322527981373399,0.13533896008571575,5898]
["O14782","Kinesin-like protein KIF3C [OS=Homo sapiens]",3,3,5,1,793,89.4,8.22,10.83,"transport;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF3C","ENSG00000084731","","Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins","",373,347,279.3,329.1,273.9,497.8,0.9077943313953487,-0.1395626153065908,0.6667331195195914,0.176047971052106,0.7857388536873094,0.10472177106944065,6202]
["O14787-2","Isoform 2 of Transportin-2 [OS=Homo sapiens]",30,19,68,11,887,100.3,4.98,205.82,"","","","TNPO2","","","","",1748.7,1752.4,1722.9,1506.4,1518.2,1350.3,1.1940844362156848,0.25590485620289904,0.006717909109954203,2.172765876247908,0.0993951370134722,1.0026348632875821,494]
["O14795","Protein unc-13 homolog B [OS=Homo sapiens]",14,16,28,16,1591,180.6,5.99,85.29,"cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","UNC13B","ENSG00000198722","Synaptic vesicle cycle","Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle","Synaptic vesicle pathway; 16p11.2 proximal deletion syndrome; Monoamine transport",1745.2,1765.7,1752.2,1847.4,1900.7,2540.4,0.83694044684742,-0.2568031245544805,0.1996730674939482,0.6996805101296261,0.4585015552350824,0.33865918686665625,3183]
["O14802","DNA-directed RNA polymerase III subunit RPC1 [OS=Homo sapiens]",22,26,44,25,1390,155.5,8.48,120,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR3A","ENSG00000148606","RNA polymerase; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","Pyrimidine metabolism; Cytosolic DNA-sensing pathway",4751.8,4815.2,4573.6,4610.6,4636.6,4556,1.0244436072794716,0.034840570256960995,0.21361103286765876,0.6703763200432827,0.4736902424847445,0.32450556118438795,3296]
["O14818-1","Proteasome subunit alpha type-7 [OS=Homo sapiens]",63,16,110,16,248,27.9,8.46,348.28,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","HEL-S-276; PSMA7","ENSG00000101182","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease",12219.4,12270.2,12869.8,12164.8,11610.6,8384.4,1.1616801099509322,0.2162128507360915,0.22120841768401872,0.6551983507662439,0.4820549567240587,0.3169034471523378,3354]
["O14828","Secretory carrier-associated membrane protein 3 [OS=Homo sapiens]",56,13,79,13,347,38.3,7.64,296.69,"transport","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SCAMP3","ENSG00000116521; ENSG00000263290","","","",5721.2,4875.5,5053.2,5118.4,5874.1,5729.6,0.9358812589327897,-0.09560259714679732,0.3603505347303015,0.44327482914707556,0.5880335026442898,0.2305979297077904,4479]
["O14832","Phytanoyl-CoA dioxygenase, peroxisomal [OS=Homo sapiens]",5,2,2,2,338,38.5,8.47,4.08,"other metabolic processes","cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","PHYH","ENSG00000107537","Peroxisome","TYSND1 cleaves peroxisomal proteins; Alpha-oxidation of phytanate","",199.9,162.1,179.4,169.8,191.3,148.7,1.061985092193017,0.08676351419276207,0.5567914428961283,0.2543074478435245,0.7078776580497133,0.15004179460552639,5749]
["O14836","Tumor necrosis factor receptor superfamily member 13B [OS=Homo sapiens]",7,1,1,1,293,31.8,7.94,4.71,"developmental processes;signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","TNFRSF13B","ENSG00000240505","Cytokine-cytokine receptor interaction; Intestinal immune network for IgA production; Primary immunodeficiency","TNFs bind their physiological receptors","",36,50.2,34.9,60.8,62.7,176.9,0.4031291611185087,-1.3106859478199429,0.19740419625819428,0.7046436196886282,0.4555817083836886,0.3414337211765673,3167]
["O14867","Transcription regulator protein BACH1 [OS=Homo sapiens]",9,6,6,6,736,81.9,5.05,18.29,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","BACH1","ENSG00000156273","","Heme signaling; Regulation of HMOX1 expression and activity; Regulation of BACH1 activity","Integrated cancer pathway; Ferroptosis",299.5,318.3,277.9,314.9,280.4,374.4,0.9236877384758174,-0.11452287776057059,0.4547862824117318,0.3421926432867122,0.637887725608779,0.1952557545695003,5211]
["O14874","[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial [OS=Homo sapiens]",24,7,11,7,412,46.3,8.82,34.8,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","kinase activity;other molecular function","BCKDK","ENSG00000103507","","Branched-chain amino acid catabolism","Thiamine metabolic pathways",1191.6,1445.1,1192.6,1556.8,1344.9,1617.2,0.8473964902963109,-0.23889094145413708,0.12328309416878717,0.9090964741958096,0.370508279309073,0.431202082912534,2432]
["O14880","Microsomal glutathione S-transferase 3 [OS=Homo sapiens]",38,4,23,4,152,16.5,9.38,79.97,"other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","MGST3","ENSG00000143198","Glutathione metabolism; Metabolism of xenobiotics by cytochrome P450; Drug metabolism; Drug metabolism; Metabolic pathways; Platinum drug resistance; Pathways in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Chemical carcinogenesis; Hepatocellular carcinoma; Fluid shear stress and atherosclerosis","Aflatoxin activation and detoxification; Glutathione conjugation","Nuclear receptors meta-pathway; NRF2 pathway; Metapathway biotransformation Phase I and II",3502.3,3272.2,3424.9,3059.4,3020.6,1386.6,1.3660032678863203,0.44996093498799555,0.17630541540549152,0.7537343476859212,0.4343162390288971,0.36219393211879,2967]
["O14893","Gem-associated protein 2 [OS=Homo sapiens]",14,3,6,3,280,31.6,5.58,17.9,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","","GEMIN2","ENSG00000092208","","snRNP Assembly","",412.7,364.6,492.8,461.3,546.8,1025.1,0.6246803069053709,-0.6788100453389669,0.2291384256177336,0.639902075217376,0.4892704507274364,0.31045101247128004,3423]
["O14920-1","Inhibitor of nuclear factor kappa-B kinase subunit beta [OS=Homo sapiens]",26,12,24,12,756,86.5,5.78,76.67,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","IKBKB","ENSG00000104365","Antifolate resistance; MAPK signaling pathway; Ras signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; FoxO signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; TNF signaling pathway; Neurotrophin signaling pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; Alcoholic liver disease; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Chagas disease; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Pancreatic cancer; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; CLEC7A (Dectin-1) signaling; IKK complex recruitment mediated by RIP1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation","Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNAs involvement in the immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Nonalcoholic fatty liver disease; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; Insulin signaling; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; T-cell receptor (TCR) signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway",1784.7,1887.1,1800,1795.6,1692.1,1936.7,1.0087382936361626,0.01255193118726775,0.8488485883246248,0.07116976926066707,0.9036170014658729,0.04401560646642542,6866]
["O14929","histone acetyltransferase type B catalytic subunit [OS=Homo sapiens]",44,14,93,14,419,49.5,5.69,261.91,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","mitochondrion;nucleus;other cell component","other molecular function","HAT1","ENSG00000128708","Neutrophil extracellular trap formation; Alcoholism","HATs acetylate histones","Ethanol effects on histone modifications",10904.7,11242.2,11706.2,10441.6,9834.6,9981.5,1.1188259517412098,0.16198562336553143,0.01542841924651171,1.811678568278077,0.14457220034968474,0.8399152090845845,780]
["O14933","Ubiquitin/ISG15-conjugating enzyme E2 L6 [OS=Homo sapiens]",15,2,3,2,153,17.8,7.88,9.18,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","UBE2L6","ENSG00000156587","Ubiquitin mediated proteolysis; Parkinson disease; Pathways of neurodegeneration","Antigen processing: Ubiquitination & Proteasome degradation; Amyloid fiber formation; ISG15 antiviral mechanism; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling","Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway; 7q11.23 copy number variation syndrome",328.8,266.7,557.9,619.4,783.5,462.4,0.6183455744384281,-0.6935147532171658,0.1378221280928381,0.860681048487205,0.3902913344558518,0.4086110911471009,2581]
["O14936","peripheral plasma membrane protein CASK [OS=Homo sapiens]",6,5,8,5,926,105.1,6.43,25.47,"cell adhesion;protein metabolism;other metabolic processes;transport;other biological processes","extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","CASK","ENSG00000147044","","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Assembly and cell surface presentation of NMDA receptors; Nephrin family interactions; Neurexins and neuroligins; Dopamine Neurotransmitter Release Cycle; Syndecan interactions","Parkin-ubiquitin proteasomal system pathway; Splicing factor NOVA regulated synaptic proteins",747.6,776.4,761.5,609.2,608.6,881.8,1.088540674414174,0.12239531628061945,0.5347531882141051,0.2718466174723477,0.6903057316596423,0.16095852061745886,5662]
["O14949","Cytochrome b-c1 complex subunit 8 [OS=Homo sapiens]",30,4,17,4,82,9.9,10.08,40.67,"other metabolic processes;transport;developmental processes","other membranes;mitochondrion","","UQCRQ","ENSG00000164405","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly",3159.5,2596.4,4241.1,3560.8,4564.9,2446,0.9456378822705903,-0.08064026382494964,0.8179299576644852,0.08728388496219983,0.8857979049592121,0.052665351219615845,6749]
["O14950","Myosin regulatory light chain 12B [OS=Homo sapiens]",66,11,109,11,172,19.8,4.84,318.93,"other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYL12B","ENSG00000118680","Axon guidance; Focal adhesion; Tight junction; Platelet activation; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Shigellosis; Salmonella infection","RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs","Thyroid stimulating hormone (TSH) signaling pathway; Focal adhesion",6881.5,6179.9,8096.5,8901,9224.1,9556.3,0.7643363413700175,-0.3877204680819077,0.021210124858137416,1.6734567749044427,0.16633562509455618,0.779014725374451,932]
["O14964","Hepatocyte growth factor-regulated tyrosine kinase substrate [OS=Homo sapiens]",26,19,36,19,777,86.1,6.16,92.11,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","HGS","ENSG00000185359","Endocytosis; Phagosome","Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; Endosomal Sorting Complex Required For Transport (ESCRT); Ub-specific processing proteases; RHOU GTPase cycle; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Inhibition of membrane repair; Prevention of phagosomal-lysosomal fusion; RHOBTB3 ATPase cycle","TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway",4409,4057.9,4496,4465.3,4814.4,6327.4,0.8305771091362264,-0.26781398352764607,0.20759343239312755,0.6827863903252275,0.46643110893371326,0.3312124917231081,3253]
["O14965","Aurora kinase A [OS=Homo sapiens]",15,5,6,5,403,45.8,9.39,16.59,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","AURKA","ENSG00000087586","Oocyte meiosis; Progesterone-mediated oocyte maturation","APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; SUMOylation of DNA replication proteins; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Interaction between PHLDA1 and AURKA","Integrated breast cancer pathway; Gastric cancer network 1; EGF/EGFR signaling pathway",481.1,551.3,533.7,536.9,485.6,846.2,0.8380692459998932,-0.25485864245038725,0.4284199574928613,0.3681303062175451,0.6227767440961264,0.20566761334749228,5028]
["O14967","calmegin [OS=Homo sapiens]",22,10,25,9,610,70,4.69,63.37,"cell organization and biogenesis;stress response;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","CLGN","ENSG00000153132","","","",1546,1518.5,1651,1482,1599.7,1672.4,0.9918806924549336,-0.01176149721383416,0.8603680078131892,0.06531574692301376,0.9111025455095045,0.040432739994508825,6902]
["O14972","Down syndrome critical region protein 3 [OS=Homo sapiens]",16,3,8,3,297,33,7.68,19.29,"transport","other cytoplasmic organelle","","VPS26C","ENSG00000157538","","","",538.2,578,627.7,534.5,480.3,399,1.2334842269062103,0.30273926739346113,0.07981579417169689,1.0979111607432732,0.3068772433460981,0.5130353157247435,1901]
["O14974","Protein phosphatase 1 regulatory subunit 12A [OS=Homo sapiens]",51,50,148,3,1030,115.2,5.4,403.41,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP1R12A","ENSG00000058272","cGMP-PKG signaling pathway; cAMP signaling pathway; Vascular smooth muscle contraction; Focal adhesion; Platelet activation; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Proteoglycans in cancer","Regulation of PLK1 Activity at G2/M Transition; RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs","Focal adhesion; Hippo-Merlin signaling dysregulation; Regulation of actin cytoskeleton",20949.5,20925.8,20690,22099,22183.2,14814.9,1.0586864668486273,0.08227539415001311,0.660802457342933,0.17992835066271717,0.7824080934261295,0.10656666574585374,6173]
["O14974-4","Isoform 4 of Protein phosphatase 1 regulatory subunit 12A [OS=Homo sapiens]",53,48,152,1,971,109,5.41,415.41,"","","","PPP1R12A","","","","",573.3,575,577.5,615.7,604.8,512.4,0.995902821859311,-0.00592312092891432,0.9459276033005644,0.024142101114308173,0.9646692971290394,0.015621543699875517,7167]
["O14975","very long-chain acyl-CoA synthetase [OS=Homo sapiens]",23,11,29,11,620,70.3,8.51,72.21,"other metabolic processes;transport","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","transporter activity;other molecular function","SLC27A2","ENSG00000140284","PPAR signaling pathway; Peroxisome; Insulin resistance","Peroxisomal protein import; Neutrophil degranulation; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Alpha-oxidation of phytanate; Synthesis of bile acids and bile salts via 24-hydroxycholesterol","PPAR signaling pathway",2424.4,2367.4,2382.5,2091.2,2281.9,3344.1,0.9296506504949982,-0.1052394211241816,0.6668654448414052,0.17596178596042372,0.7856414468642539,0.10477561321801805,6204]
["O14976","Cyclin-G-associated kinase [OS=Homo sapiens]",23,22,59,22,1311,143.1,5.73,183.19,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;ER/Golgi;other cell component","kinase activity;other molecular function","GAK","ENSG00000178950","","Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis","",5277.2,5294.3,5455.5,5640.1,5590.7,6262.5,0.9161793372319689,-0.12629806904205423,0.0940278819177364,1.0267433467458773,0.32882765020896426,0.4830316709729583,2090]
["O14979-1","Heterogeneous nuclear ribonucleoprotein D-like [OS=Homo sapiens]",30,15,127,13,420,46.4,9.57,302.04,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","HNRNPDL; HNRPDL","ENSG00000152795; ENSPPAG00000043177; ENSPTRG00000016217","","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","",12250.1,10759.2,11566.8,12641.1,14005.7,8899.1,0.9727169659510663,-0.039908013642267724,0.848451217412046,0.07137312284283522,0.903457160265828,0.04409243579951133,6864]
["O14980","Exportin-1 [OS=Homo sapiens]",47,39,166,39,1071,123.3,6.06,503.63,"transport;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","XPO1","ENSG00000082898","Ribosome biogenesis in eukaryotes; Nucleocytoplasmic transport; Influenza A; Human T-cell leukemia virus 1 infection","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; MAPK6/MAPK4 signaling; Deactivation of the beta-catenin transactivating complex; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Heme signaling; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Downregulation of TGF-beta receptor signaling; HuR (ELAVL1) binds and stabilizes mRNA; Cyclin A/B1/B2 associated events during G2/M transition","eIF5A regulation in response to inhibition of the nuclear export system; 22q11.2 copy number variation syndrome",17583.8,17771.1,17518.6,16609.7,15939.8,14510.8,1.1235266243521607,0.16803431264929544,0.035960684052546,1.4441720556089848,0.20909836097061155,0.6796493714109695,1257]
["O14981","TATA-binding protein-associated factor 172 [OS=Homo sapiens]",15,20,44,20,1849,206.8,6.52,146.79,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","BTAF1","ENSG00000095564","","","",3195.2,3059.5,3228,3293.8,3497.7,3862.9,0.8900266556540021,-0.16807955048925918,0.08851683550617279,1.0529741205781848,0.32091743587034566,0.49360668646769956,2016]
["O14986","Phosphatidylinositol 4-phosphate 5-kinase type-1 beta [OS=Homo sapiens]",5,2,3,1,540,61,6.86,6.4,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;other cell component","kinase activity;other molecular function","PIP5K1B","ENSG00000107242","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Phospholipase D signaling pathway; Endocytosis; Focal adhesion; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Yersinia infection; Choline metabolism in cancer","Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; WNT mediated activation of DVL","B cell receptor signaling pathway; Wnt signaling pathway; Regulation of actin cytoskeleton",37.3,33.2,28.2,40,37.5,56.3,0.7376681614349775,-0.43895612618506347,0.14411837315649118,0.8412806489443243,0.3964475684609688,0.4018142414706288,2657]
["O15014","zinc finger protein 609 [OS=Homo sapiens]",1,1,1,1,1411,151.1,8.03,2.25,"developmental processes;other biological processes","nucleus","other molecular function","ZNF609","ENSG00000180357","","","",120.6,109.8,103.3,191,173.3,185.5,0.6069479810840306,-0.7203552203306338,5.8146610194968946E-4,3.235475598502703,0.034273675315728065,1.465039321780965,124]
["O15015","Zinc finger protein 646 [OS=Homo sapiens]",1,1,1,1,1829,200.6,7.33,3.44,"","","","","","","","",88.3,104.1,99.7,117.5,116.3,257.6,0.5944240944240944,-0.7504354995329862,0.2315222731742508,0.6354072221347344,0.4922036924463639,0.30785513260179503,3438]
["O15020","Spectrin beta chain, non-erythrocytic 2 [OS=Homo sapiens]",13,30,70,16,2390,271.2,6.11,202.36,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SPTBN2","ENSG00000173898","Spinocerebellar ataxia; Pathways of neurodegeneration","MHC class II antigen presentation; COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins","",867.2,961.1,852,907,941.9,2017.4,0.693246773400926,-0.5285590983854154,0.34091287053998465,0.46735660247019806,0.5774582087547504,0.23847944063745344,4315]
["O15027-5","Isoform 5 of Protein transport protein Sec16A [OS=Homo sapiens]",22,34,83,34,2201,235.6,5.67,232.92,"","","","","","","","",7512.1,7651.5,7621.7,7680.2,7940.7,10692,0.8659364798254847,-0.20766689395590582,0.2897156877554632,0.5380279876365314,0.5400489573590106,0.2675668680527652,3921]
["O15031","Plexin-B2 [OS=Homo sapiens]",6,10,18,9,1838,205,6.24,46.43,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","PLXNB2","ENSG00000196576","Axon guidance","","",791.1,816.7,784.9,748.7,678.7,1592.7,0.792258534485613,-0.33595679898133396,0.5159660821605477,0.28737884646321943,0.6792500170229545,0.16797034202604494,5552]
["O15037","protein KHNYN [OS=Homo sapiens]",7,4,4,4,678,74.5,7.02,12.78,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KHNYN","ENSG00000100441","","","",334.9,360.5,324.4,320.6,326.6,443.7,0.9348244568704738,-0.0972326164959813,0.5983288116784549,0.22306008381732928,0.7379657921967309,0.13196376907738855,5926]
["O15042-2","Isoform 2 of U2 snRNP-associated SURP motif-containing protein [OS=Homo sapiens]",31,24,78,1,1028,118.2,8.47,207.63,"","","","U2SURP","","","","",6907.2,6847.9,6910.6,7732.4,7754.8,5273.8,0.995409662347671,-6.63770369982415E-3,0.9710791088586097,0.012745388896011772,0.9827772371431153,0.007544911102846614,7222]
["O15047","Histone-lysine N-methyltransferase SETD1A [OS=Homo sapiens]",6,8,12,8,1707,185.9,5.14,36.58,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SETD1A","ENSG00000099381","Lysine degradation; Metabolic pathways","PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","Histone modifications",697,672.6,658.5,645.7,674.9,1386.3,0.749233440466955,-0.4165128021948436,0.4034478286559204,0.39421261755098563,0.6097601694884455,0.21484094785574692,4836]
["O15050","TPR and ankyrin repeat-containing protein 1 [OS=Homo sapiens]",1,1,1,1,2925,336,6.76,0,"","","","TRANK1","ENSG00000168016","","","",26.8,32.2,27.1,30.9,24.4,35.5,0.948237885462555,-0.07667905989407103,0.6911056021470185,0.1604555865974094,0.8000143880412668,0.09690220226963502,6314]
["O15056","Synaptojanin-2 [OS=Homo sapiens]",3,4,4,4,1496,165.4,7.34,11.76,"cell organization and biogenesis;other metabolic processes;transport;developmental processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity;other molecular function","SYNJ2","ENSG00000078269","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane","",324.8,358,340.8,394.9,354,683.2,0.7147545562460722,-0.4844801834550358,0.2607111227734279,0.5838404400396567,0.5179498766923035,0.2857122659868107,3679]
["O15061-1","Synemin [OS=Homo sapiens]",4,5,5,5,1565,172.7,5.16,13.83,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SYNM","ENSG00000182253","","","",166.5,169.4,162.8,159.9,165.8,252.1,0.8631014191761853,-0.2123980008995016,0.4271036633924573,0.36946670348699934,0.6221005730839918,0.206139398581618,5018]
["O15062","zinc finger and BTB domain-containing protein 5 [OS=Homo sapiens]",2,1,1,1,677,74.2,6.19,3.91,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB5","ENSG00000168795","","","",48.5,44.9,52.6,54.3,63.8,123.1,0.6053067993366501,-0.7242615381327052,0.2164213361865899,0.6646999259530556,0.4774595672163554,0.32106339995104266,3313]
["O15066","Kinesin-like protein KIF3B [OS=Homo sapiens]",18,11,14,9,747,85.1,7.69,41.08,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF3B","ENSG00000101350","","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins","",1159.3,1187,1110.8,1330.2,1336.7,1117.4,0.9135375102396744,-0.13046412714490385,0.22159752269089267,0.6544350990324574,0.4824713414798137,0.31652847839649695,3357]
["O15067","Phosphoribosylformylglycinamidine synthase [OS=Homo sapiens]",33,35,110,35,1338,144.6,5.76,331.34,"other metabolic processes;other biological processes","cytosol","other molecular function","PFAS","ENSG00000178921","Purine metabolism; Metabolic pathways","Purine ribonucleoside monophosphate biosynthesis","",13583.7,13186.4,13274.7,12803.2,13171.3,14186.5,0.997106645750853,-4.1802782602057015E-3,0.9326824213419352,0.030266208490860664,0.9567685358018533,0.019193115287435517,7125]
["O15078-1","Centrosomal protein of 290 kDa [OS=Homo sapiens]",1,2,4,2,2479,290.2,5.95,10.65,"cell organization and biogenesis;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","CEP290","ENSG00000198707","","Neutrophil degranulation; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","Clear cell renal cell carcinoma pathways; Ciliary landscape; Joubert syndrome; Ciliopathies",1115.6,1081.5,1229.1,1358.8,1425.2,1782.5,0.7502901565750574,-0.4144794639477431,0.05212391042699359,1.2829630102050447,0.24932831237624092,0.6032284025607428,1528]
["O15084","serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A [OS=Homo sapiens]",14,11,22,9,1053,112.9,6.25,80.85,"","cytosol;nucleus","","ANKRD28","ENSG00000206560","","Telomere Extension By Telomerase; COPII-mediated vesicle transport","",1375.5,1484.1,1418.7,1468.1,1427.2,1690.3,0.9329858688066992,-0.1000728649967045,0.3073142273056773,0.512417333341672,0.5558425358518178,0.25504822190034715,4041]
["O15085-1","Rho guanine nucleotide exchange factor 11 [OS=Homo sapiens]",1,2,2,2,1522,167.6,5.5,5.16,"cell organization and biogenesis;signal transduction;other biological processes","other membranes;cytosol;other cell component","signal transduction activity or receptor binding;enzyme regulator activity","ARHGEF11","ENSG00000132694","Vascular smooth muscle contraction; Parathyroid hormone synthesis, secretion and action; Pathogenic Escherichia coli infection; Human cytomegalovirus infection; Pathways in cancer","RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOB GTPase cycle; Sema4D induced cell migration and growth-cone collapse","",164,161.9,167.4,161.6,166.3,260.6,0.838232795242141,-0.2545771279313141,0.38130003715054395,0.4187331524124677,0.5968991157706844,0.22409906445930058,4669]
["O15091","Mitochondrial ribonuclease P protein 3 [OS=Homo sapiens]",19,10,14,10,583,67.3,8.78,42.78,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus","other molecular function","PRORP","ENSG00000100890","","tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion","",1332.9,1211.6,1269.8,1204.9,1384.1,807.2,1.1231081797302869,0.16749689732327294,0.468109933964156,0.3296521424229988,0.6461596803293703,0.1896601449825297,5295]
["O15111","Inhibitor of nuclear factor kappa-B kinase subunit alpha [OS=Homo sapiens]",8,4,5,4,745,84.6,6.73,16.69,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","CHUK","ENSG00000213341","Antifolate resistance; MAPK signaling pathway; Ras signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; FoxO signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; TNF signaling pathway; Adipocytokine signaling pathway; Alcoholic liver disease; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Chagas disease; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Chemical carcinogenesis; Pancreatic cancer; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Constitutive Signaling by AKT1 E17K in Cancer; IKK complex recruitment mediated by RIP1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; AKT phosphorylates targets in the cytosol","Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Canonical and non-canonical Notch signaling; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Chemokine signaling pathway; IL-4 signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNAs involvement in the immune response in sepsis; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - interferon induction; Neuroinflammation; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; T-cell receptor (TCR) signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway",388.5,403,354.4,363.1,333.5,503.5,0.9548370969085911,-0.06667347642914671,0.7563829501165679,0.12125826929519809,0.8436445875785128,0.07384047536736381,6553]
["O15116","U6 snRNA-associated Sm-like protein LSm1 [OS=Homo sapiens]",35,4,6,4,133,15.2,5.22,15.68,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","LSM1","ENSG00000175324","RNA degradation","mRNA decay by 5' to 3' exoribonuclease","",490.2,485.5,533.8,558.2,546.3,1157.9,0.667211810466761,-0.5837832684084112,0.2829603542007578,0.5482744095569664,0.5349604834074855,0.2716782973655276,3866]
["O15118","Niemann-Pick C1 protein [OS=Homo sapiens]",4,5,16,5,1278,142.1,5.36,47.77,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","NPC1","ENSG00000141458","Lysosome; Cholesterol metabolism","LDL clearance","Irinotecan pathway; Irinotecan pathway; Irinotecan pathway; Ebola virus pathway in host; Irinotecan pathway; Irinotecan pathway",1428.1,1326.8,1396.7,1239.9,1277.1,1189.6,1.1200561161171962,0.16357101479707842,0.019419276795575296,1.7117669479367343,0.16037908937724274,0.7948522567505868,885]
["O15121","Sphingolipid delta(4)-desaturase DES1 [OS=Homo sapiens]",5,1,4,1,323,37.8,7.46,17.04,"cell organization and biogenesis;other metabolic processes;developmental processes","plasma membrane;other membranes;mitochondrion;ER/Golgi","other molecular function","DEGS1","ENSG00000143753","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway","Neutrophil degranulation; Sphingolipid de novo biosynthesis","Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway; Sphingolipid metabolism in senescence",279.5,318.2,308.4,240.3,276.3,244.9,1.1898883782009193,0.2508262426348608,0.041032396227675696,1.3868731201749436,0.22198799706001604,0.6536705073130011,1351]
["O15126-1","Secretory carrier-associated membrane protein 1 [OS=Homo sapiens]",12,4,6,4,338,37.9,7.42,21.87,"transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","SCAMP1","ENSG00000085365","","Neutrophil degranulation","",778.8,712.6,710.8,827.5,964.6,1194.7,0.7373108343377527,-0.43965513822890134,0.07518881714142966,1.1238467473726794,0.29964834486734426,0.5233881168227088,1834]
["O15127","Secretory carrier-associated membrane protein 2 [OS=Homo sapiens]",16,5,25,5,329,36.6,6.1,97.67,"transport","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","SCAMP2","ENSG00000140497","","","Serotonin transporter activity; Monoamine transport",2743.5,2389.3,2312.2,2190,2172.4,2220.4,1.1309776994591967,0.17757048264619912,0.09773184382705426,1.009963907672338,0.33379534884670076,0.4765197191375557,2140]
["O15143","Actin-related protein 2/3 complex subunit 1B [OS=Homo sapiens]",51,17,75,16,372,40.9,8.35,254.53,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","ARPC1B","ENSG00000130429","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling","Pathogenic Escherichia coli infection; Microglia pathogen phagocytosis pathway",13594.9,13030.1,13674,12658,12872.7,9442.8,1.1522724348435243,0.20448185734468804,0.1905443625946426,0.7200038956467653,0.4491095602077532,0.34764770000011874,3101]
["O15144","Actin-related protein 2/3 complex subunit 2 [OS=Homo sapiens]",67,19,142,19,300,34.3,7.36,398.24,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity","ARPC2","ENSG00000163466","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling","Pathogenic Escherichia coli infection",21174.8,23258,24026.7,19720,17620.2,12857.7,1.3637921108253532,0.44762374440658087,0.05059392981544321,1.2959015860415717,0.24521951791848437,0.610444965691354,1508]
["O15145","Actin-related protein 2/3 complex subunit 3 [OS=Homo sapiens]",31,6,26,6,178,20.5,8.59,47.95,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity","ARPC3","ENSG00000111229","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection","Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling","Pathogenic Escherichia coli infection",1838.3,1990.2,3178.8,2440.7,3381.1,1933.8,0.9035148795708908,-0.14637973452092817,0.6987041468012039,0.15570667920517295,0.8056205409323235,0.09386946909317581,6339]
["O15155","BET1 homolog [OS=Homo sapiens]",51,3,4,3,118,13.3,9.06,15.06,"cell organization and biogenesis;transport","other membranes;ER/Golgi","other molecular function","BET1","ENSG00000105829","SNARE interactions in vesicular transport","COPI-mediated anterograde transport; COPII-mediated vesicle transport","",234.1,235.8,216.7,209,215.8,338.3,0.8997510155942864,-0.1524022692938879,0.5804441439797199,0.2362395659831517,0.7234765089269735,0.14057556573225033,5864]
["O15156","Zinc finger and BTB domain-containing protein 7B [OS=Homo sapiens]",5,1,1,1,539,58,5.86,3.39,"RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZBTB7B","ENSG00000160685","","","Ectoderm differentiation; Ectoderm differentiation",19.3,24.2,19.5,14.9,15,26.6,1.1150442477876108,0.15710096108472899,0.6331889669613795,0.1984666611336503,0.7640710185769725,0.11686627291297912,6057]
["O15160","DNA-directed RNA polymerases I and III subunit RPAC1 [OS=Homo sapiens]",37,9,25,9,346,39.2,5.5,78.2,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR1C","ENSG00000171453","RNA polymerase; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","Pyrimidine metabolism; Cytosolic DNA-sensing pathway",1423.5,1481.2,1468.3,1537.9,1599.4,1806.7,0.8845064724919094,-0.17705539482316696,0.08399817322240048,1.0757301587959516,0.3145197992226051,0.5023520102426516,1952]
["O15162","phospholipid scramblase 1 [OS=Homo sapiens]",3,1,1,1,318,35,4.94,2.06,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","extracellular matrix;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;transporter activity;nucleic acid binding activity;other molecular function","PLSCR1","ENSG00000188313","","","EGF/EGFR signaling pathway; Complement system in neuronal development and plasticity",44.4,42.9,39.4,35.3,25.5,18.6,1.595717884130982,0.6742056119978513,0.03580332890626294,1.4460765918363305,0.20901480109894235,0.6798229588267685,1252]
["O15164","Transcription intermediary factor 1-alpha [OS=Homo sapiens]",14,10,14,9,1050,116.8,7.11,36.53,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;kinase activity;other molecular function","TRIM24","ENSG00000122779","","Signaling by BRAF and RAF1 fusions; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease","",1136.6,1099.3,1083.8,1138,1105.9,2018.8,{"$f":"AVERAGE(S258:U258)/AVERAGE(V258:X258)","v":0.778778708330401},{"$f":"LOG(Y258,2)","v":-0.36071465331251734},{"$f":"TTEST(V258:X258,S258:U258,2,2)","v":0.35316604028326276},0.45202106394683805,{"$f":"AA258*7309/AE258","v":0.5847962366176638},0.23299543088850128,4414]
["O15173","Membrane-associated progesterone receptor component 2 [OS=Homo sapiens]",49,13,55,11,223,23.8,4.88,196.01,"transport;developmental processes;signal transduction","other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","PGRMC2","ENSG00000164040","","RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle","Ciliary landscape",5965.2,5799.5,5785.7,5516.9,5889.3,6640.6,0.9724937385021166,-0.040239133694472254,0.6476950917201569,{"$f":"-LOG10(AA259)","v":0.1886293940483583},0.7730247265484368,{"$f":"-LOG10(AC259)","v":0.11180661419060876},6124]
["O15182","Centrin-3 [OS=Homo sapiens]",15,3,3,3,167,19.5,4.74,7.09,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","CETN3","ENSG00000153140","","","Breast cancer pathway",228,204.1,288.7,397.5,471.3,230.9,0.6554514867691188,-0.6094390915382619,0.16935230290624342,0.7712088933053047,0.42550566584452837,0.371094652668391,2909]
["O15211","Ral guanine nucleotide dissociation stimulator-like 2 [OS=Homo sapiens]",3,2,2,2,777,83.5,6.18,5.85,"signal transduction;other biological processes","cytosol","enzyme regulator activity","RGL2","ENSG00000206282; ENSG00000224841; ENSG00000228736; ENSG00000237441; ENSG00000237825","Ras signaling pathway","RAF/MAP kinase cascade","Ras signaling",118.3,127.4,132.2,153.2,163.6,520.7,0.45122388059701485,-1.1480846718598983,0.2737570711153171,0.5626346542278009,0.527382823611453,0.2778740188964716,3794]
["O15213","WD repeat-containing protein 46 [OS=Homo sapiens]",21,11,15,11,610,68,9.67,46.35,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","WDR46","ENSG00000204221; ENSG00000206284; ENSG00000226916; ENSG00000227057; ENSG00000236222","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",924.7,903.9,957.8,1603.9,1703,2132.8,0.5122341305586704,-0.9651247108562161,5.6048138313797196E-3,2.251438808287074,0.09226482948998732,1.0349638165177208,444]
["O15226","NF-kappa-B-repressing factor [OS=Homo sapiens]",32,22,55,22,690,77.6,8.79,152.72,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","NKRF","ENSG00000186416","","","Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Network map of SARS-CoV-2 signaling pathway",4982.4,5058.2,4848.4,5878.1,5708.8,5687.8,0.8618962992121424,-0.21441379588882203,7.5938066477355764E-4,3.119540464990603,0.03827802261262023,1.417050505341605,145]
["O15228","Dihydroxyacetone phosphate acyltransferase [OS=Homo sapiens]",23,14,32,14,680,77.1,6.57,82.48,"cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;other cytoplasmic organelle","other molecular function","GNPAT","ENSG00000116906","Glycerophospholipid metabolism; Peroxisome","Peroxisomal protein import; Plasmalogen biosynthesis; Synthesis of PA","Triacylglyceride synthesis",3382.6,3913.5,3634.2,3477.7,2936.5,2952.2,1.166969166381961,0.2227664427114966,0.09060478981894415,1.0428488427541895,0.3243048035194235,0.48904661862110815,2042]
["O15229","Kynurenine 3-monooxygenase [OS=Homo sapiens]",8,3,4,3,486,55.8,9.03,13.58,"other metabolic processes;stress response;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion","other molecular function","KMO","ENSG00000117009","Tryptophan metabolism; Metabolic pathways; Biosynthesis of cofactors","Tryptophan catabolism","Selenium micronutrient network; NAD biosynthesis II (from tryptophan)",256.4,240,240.6,243,241.8,478.7,0.7649195640892579,-0.38662004720065146,0.3930752841558201,0.405524262952237,0.603568750398086,0.21927325378875712,4760]
["O15230","Laminin subunit alpha-5 [OS=Homo sapiens]",0,1,1,1,3695,399.5,7.02,3.56,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;other cell component","signal transduction activity or receptor binding;extracellular structural activity","LAMA5","ENSG00000130702","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Toxoplasmosis; Amoebiasis; Human papillomavirus infection; Pathways in cancer; Small cell lung cancer","Degradation of the extracellular matrix; ECM proteoglycans; Non-integrin membrane-ECM interactions; Interleukin-4 and Interleukin-13 signaling; Laminin interactions; MET activates PTK2 signaling","Alpha 6 beta 4 signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Complement system; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Inflammatory response pathway; Small cell lung cancer; Malignant pleural mesothelioma",16.4,28.4,20,14.3,20.3,64.6,0.6532258064516129,-0.6143463075022506,0.5194613838932596,0.2844467318130852,0.6813968511981038,0.16659987768103812,5572]
["O15234","Protein CASC3 [OS=Homo sapiens]",17,9,11,9,703,76.2,6.48,19.86,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","CASC3","ENSG00000108349","Nucleocytoplasmic transport; mRNA surveillance pathway","Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","",1280.8,1378.5,1354.3,2220.8,2193.9,2484.5,0.5817486085343229,-0.7815322399882088,5.8647770736621353E-4,3.2317484912242262,0.03429252450511724,1.4648005423483095,125]
["O15235","28S ribosomal protein S12, mitochondrial [OS=Homo sapiens]",30,3,14,3,138,15.2,10.29,40.07,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPS12","ENSG00000128626; ENSG00000283018","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1447.3,1342.5,1410.5,1434.4,1475.1,1304.3,0.9967962409226826,-4.629467147869281E-3,0.9437796370367092,0.02512939721768862,0.96355431863407,0.01612379775154967,7159]
["O15243","Leptin receptor gene-related protein [OS=Homo sapiens]",17,2,4,2,131,14.2,6.51,9.3,"transport;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","signal transduction activity or receptor binding","LEPROT","ENSG00000213625","","","",439.4,421.1,418.5,398.2,378.5,603.9,0.92640880776474,-0.11027912517624641,0.6641863750382496,0.17771003766024182,0.7841282854392774,0.10561287978917382,6191]
["O15247","Chloride intracellular channel protein 2 [OS=Homo sapiens]",57,13,57,11,247,28.3,5.59,218.71,"other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","transporter activity;other molecular function","CLIC2","ENSG00000155962","","Stimuli-sensing channels; Ion homeostasis","",2853.6,3040.5,3344.8,3318.9,3663.7,3649.4,0.8689710308502635,-0.20262001260637455,0.0633358129655252,1.1983506505642434,0.2708727074107804,0.5672347514010073,1709]
["O15254","Peroxisomal acyl-coenzyme A oxidase 3 [OS=Homo sapiens]",24,12,20,12,700,77.6,7.25,66.46,"other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle","other molecular function","ACOX3","ENSG00000087008","Fatty acid degradation; beta-Alanine metabolism; alpha-Linolenic acid metabolism; Propanoate metabolism; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Carbon metabolism; Fatty acid metabolism; PPAR signaling pathway; cAMP signaling pathway; Peroxisome; Alcoholic liver disease","Peroxisomal protein import; Beta-oxidation of pristanoyl-CoA","PPAR signaling pathway; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Omega-3 / omega-6 fatty acid synthesis",1234.3,1293.5,1161.8,1130.5,1084.8,1461.4,1.0035085810645414,0.005052953328660451,0.9741265449799053,0.01138462195438757,0.9844981909925508,6.785077537721524E-3,7232]
["O15258","Protein RER1 [OS=Homo sapiens]",24,4,18,4,196,22.9,9.54,56.74,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding","RER1","ENSG00000157916","","","",2420.7,2509.1,2339.9,2359.5,2446.1,1686.1,1.1198453409738587,0.16329949905340976,0.34972831290127915,0.45626920715586666,0.5822697583133142,0.23487576551401507,4390]
["O15260-1","surfeit locus protein 4 [OS=Homo sapiens]",21,5,34,5,269,30.4,7.78,61.06,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","","SURF4","ENSG00000148248; ENSG00000280951; ENSGGOG00000014456; ENSNLEG00000013096; ENSPTRG00000021519","","COPI-dependent Golgi-to-ER retrograde traffic; Neutrophil degranulation","",2733,2576,2764,2093.7,2134.9,1342.3,1.449137482273959,0.5351944724558365,0.034248632147865436,1.465356769061973,0.20484717869783017,0.6885700130845357,1222]
["O15264","Mitogen-activated protein kinase 13 [OS=Homo sapiens]",28,7,19,6,365,42.1,8.38,64.93,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","MAPK13","ENSG00000156711","Endocrine resistance; MAPK signaling pathway; Rap1 signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Oocyte meiosis; Cellular senescence; Adrenergic signaling in cardiomyocytes; VEGF signaling pathway; Osteoclast differentiation; Signaling pathways regulating pluripotency of stem cells; Platelet activation; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; TNF signaling pathway; Leukocyte transendothelial migration; Thermogenesis; Neurotrophin signaling pathway; Retrograde endocannabinoid signaling; Dopaminergic synapse; Inflammatory mediator regulation of TRP channels; GnRH signaling pathway; Progesterone-mediated oocyte maturation; Prolactin signaling pathway; Relaxin signaling pathway; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Alcoholic liver disease; Amyotrophic lateral sclerosis; Prion disease; Pathways of neurodegeneration; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Yersinia infection; Leishmaniasis; Chagas disease; Toxoplasmosis; Tuberculosis; Hepatitis B; Human cytomegalovirus infection; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Proteoglycans in cancer; Chemical carcinogenesis; PD-L1 expression and PD-1 checkpoint pathway in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","VEGFA-VEGFR2 Pathway; NOD1/2 Signaling Pathway; p38MAPK events; DSCAM interactions","Regulation of toll-like receptor signaling pathway; Parkinson's disease pathway; Retinoblastoma gene in cancer; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Angiopoietin-like protein 8 regulatory pathway; Oxidative damage response; Epithelial to mesenchymal transition in colorectal cancer; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Regulatory circuits of the STAT3 signaling pathway; Hepatitis B infection; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - apoptosis; Host-pathogen interaction of human coronaviruses - MAPK signaling; Toll-like receptor signaling pathway",1495,1572.6,1413.2,1598.6,1390.7,1556.8,0.9856360396823651,-0.02087308589145026,0.7950883214951436,0.09958462554800346,0.8707372702738995,0.06011286598280442,6674]
["O15269","serine palmitoyltransferase 1 [OS=Homo sapiens]",18,8,16,8,473,52.7,6.01,50.1,"other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","SPTLC1","ENSG00000090054","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway","Sphingolipid de novo biosynthesis","Sphingolipid pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway",1163.5,1285.2,1196,1210.2,1157.6,1512.7,0.9392346347120215,-0.09044248541088298,0.5367812139843834,0.27020269180643414,0.691214568888629,0.16038711670789757,5676]
["O15270","Serine palmitoyltransferase 2 [OS=Homo sapiens]",11,5,12,5,562,62.9,7.78,29.59,"other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","SPTLC2","ENSG00000100596","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway","Sphingolipid de novo biosynthesis","Sphingolipid pathway; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway",580.2,579.9,559.9,586.7,582.6,993.7,0.7951918631530283,-0.3306251003725183,0.3402629144175399,0.4681853824983616,0.577025902895081,0.23880469077512023,4310]
["O15287","Fanconi anemia group G protein [OS=Homo sapiens]",2,1,1,1,622,68.5,5.47,2.22,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus","nucleic acid binding activity","FANCG","ENSG00000221829","Fanconi anemia pathway","Fanconi Anemia Pathway","Retinoblastoma gene in cancer; DNA repair pathways, full network",29.1,25.8,20.4,26.2,31.8,37,0.7926315789473686,-0.33527764854638176,0.17763909668271866,0.7504614439351336,0.43613172914141435,0.3603823166978854,2977]
["O15294","UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit [OS=Homo sapiens]",12,12,22,12,1046,116.9,6.7,62.76,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component","other molecular function","OGT","ENSG00000147162","Other types of O-glycan biosynthesis; Insulin resistance","UCH proteinases; Regulation of necroptotic cell death; HATs acetylate histones","Ectoderm differentiation; Ectoderm differentiation",2486.3,2556,2612.7,3685.8,3531.2,4889.2,0.6323206290991392,-0.6612718075064913,0.02619067544598169,1.5818533011669766,0.18371175320026886,0.7358630582465093,1042]
["O15297","protein phosphatase 1D [OS=Homo sapiens]",7,3,3,3,605,66.6,8.94,10.35,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus","kinase activity;other molecular function","PPM1D","ENSG00000170836","p53 signaling pathway","Transcriptional regulation by RUNX2","ATM signaling in development and disease ; Genotoxicity pathway",159.1,157.5,137.5,139.4,134.1,768.7,0.43571291498752635,-1.1985502180072152,0.404977303736424,0.39256931539824813,0.6103049717545408,0.21445309211653882,4850]
["O15305","Phosphomannomutase 2 [OS=Homo sapiens]",44,12,65,11,246,28.1,6.77,167.72,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","PMM2","ENSG00000140650","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars","Defective PMM2 causes PMM2-CDG (CDG-1a); Synthesis of GDP-mannose","Nephrotic syndrome",7868.8,7796.2,7430.1,8350,8145.3,7184.9,0.9752915938209982,-0.036094472881117085,0.6382062097069741,0.1950389744634846,0.7665816247737508,0.1154415951455954,6085]
["O15315-1","Isoform 2 of DNA repair protein RAD51 homolog 2 [OS=Homo sapiens]",3,1,1,1,350,38.2,6.1,2.84,"","","","RAD51B","","","","",21.9,27.9,23.1,28.4,18.4,95.2,0.5133802816901408,-0.9619002100651074,0.3946821040921084,0.40375256519365804,0.6036265952729065,0.21923163383047903,4779]
["O15320","Endoplasmic reticulum export factor CTAGE5 [OS=Homo sapiens]",31,22,47,22,804,90.9,5.22,160.23,"","","","","","","","",5674.4,5646.1,5442.8,5428.3,5866.5,4146.1,1.0856426762688705,0.11854933886804273,0.4454050479950468,0.3512448652005658,0.6327435365978226,0.19877228241504458,5145]
["O15321-1","Transmembrane 9 superfamily member 1 [OS=Homo sapiens]",5,2,3,2,606,68.8,7.17,10.15,"other metabolic processes;other biological processes","other membranes;other cytoplasmic organelle;other cell component","","TM9SF1","ENSCANG00000029500; ENSCCAG00000032112; ENSG00000100926; ENSG00000285465; ENSPPAG00000042444; ENSPTRG00000032568; ENSRBIG00000029944; ENSRROG00000042511","","","",271.3,290.1,288.5,303.7,288.8,221.4,1.0442314780685589,0.06244155409623253,0.66866866194438,0.17478903011780364,0.7867513280990782,0.10416251529035155,6212]
["O15344-1","E3 ubiquitin-protein ligase Midline-1 [OS=Homo sapiens]",10,6,6,6,667,75.2,6.8,19.65,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","MID1","ENSCANG00000031338; ENSCCAG00000029160; ENSCJAG00000000987; ENSCSAG00000015273; ENSG00000101871; ENSMFAG00000037182; ENSMLEG00000034816; ENSMMUG00000020179; ENSMNEG00000026727; ENSPANG00000006683; ENSPPAG00000038224; ENSRBIG00000037000; ENSTSYG00000003295","Ubiquitin mediated proteolysis","Interferon gamma signaling","",349.5,357.1,378.8,346.4,354.8,455.9,0.9380347420274826,-0.09228673800752059,0.5458505066559431,0.26292628224774495,0.6994427337216494,0.15524783720758115,5704]
["O15347","High mobility group protein B3 [OS=Homo sapiens]",23,4,6,3,200,23,8.37,19.09,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","HMGB3","ENSG00000029993","","","",556.6,547.1,429.9,480.5,412.6,797.5,0.9071335620489768,-0.14061311291009915,0.697899024153058,0.15620740893191576,0.8057090455749014,0.09382176056941392,6331]
["O15355","Protein phosphatase 1G [OS=Homo sapiens]",51,23,124,23,546,59.2,4.36,418.89,"protein metabolism;other metabolic processes;other biological processes","other membranes;nucleus;other cell component","other molecular function","PPM1G","ENSG00000115241","","","VEGFA-VEGFR2 signaling pathway; mRNA processing",16553.6,15569.5,15882.4,16651.6,18717.2,16347.2,0.9282523783741975,-0.10741098832012425,0.19657308010135474,0.7064759573275229,0.45466855774076004,0.3423050780619538,3160]
["O15357","Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 [OS=Homo sapiens]",25,21,39,20,1258,138.5,6.54,114.09,"cell adhesion;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","INPPL1","ENSG00000165458","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; B cell receptor signaling pathway; Fc gamma R-mediated phagocytosis; Insulin signaling pathway","Synthesis of PIPs at the plasma membrane; Interleukin receptor SHC signaling; Synthesis of IP3 and IP4 in the cytosol","EGF/EGFR signaling pathway; Insulin signaling",2898.4,2842,2876.2,2912.5,2956.6,3269,0.9429312439128482,-0.08477551771165985,0.20006888733744768,0.6988204431390894,0.4589778711705603,0.3382082527202291,3186]
["O15360","Fanconi anemia group A protein [OS=Homo sapiens]",2,2,2,2,1455,162.7,6.6,5.6,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","","FANCA","ENSG00000187741","Fanconi anemia pathway","Fanconi Anemia Pathway","DNA repair pathways, full network",149.6,123.4,141.5,164.3,174.6,214.2,0.7494124028204665,-0.4161682403328124,0.053716881853486005,1.2698892051084603,0.2521622925286636,0.5983198557926076,1557]
["O15371","Eukaryotic translation initiation factor 3 subunit D [OS=Homo sapiens]",58,23,96,23,548,63.9,6.05,317.05,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity","EIF3D","ENSG00000100353","","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","Translation factors; VEGFA-VEGFR2 signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell",8164.9,8285.9,8047.6,8291.1,8385.6,6068.7,1.0770705285464315,0.10711272328293604,0.48494517854797636,0.31430735418082495,0.656747139152707,0.18260181036206574,5397]
["O15372","Eukaryotic translation initiation factor 3 subunit H [OS=Homo sapiens]",53,18,89,18,352,39.9,6.54,252.59,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3H","ENSG00000147677","Measles","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","Translation factors; VEGFA-VEGFR2 signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell",10729.8,11315.9,11107.8,11781.7,11401.3,13680.3,0.8993633234138017,-0.15302404366665254,0.16347083932649553,0.7865597075240862,0.4204111064874581,0.37632581923156416,2842]
["O15379","Histone deacetylase 3 [OS=Homo sapiens]",11,5,13,5,428,48.8,5.16,34.32,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","HDAC3","ENSG00000171720","Neutrophil extracellular trap formation; Thyroid hormone signaling pathway; Alcoholism; Viral carcinogenesis","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Regulation of PTEN gene transcription; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Cytoprotection by HMOX1; Association of TriC/CCT with target proteins during biosynthesis; NR1D1 (REV-ERBA) represses gene expression; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RUNX2 regulates osteoblast differentiation; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; STAT3 nuclear events downstream of ALK signaling","Neural crest differentiation; Initiation of transcription and translation elongation at the HIV-1 LTR; Ethanol effects on histone modifications; Transcription co-factors SKI and SKIL protein partners; 22q11.2 copy number variation syndrome; IL-18 signaling pathway; 7q11.23 copy number variation syndrome; 16p11.2 proximal deletion syndrome",1412.3,1448.6,1318.7,1539.3,1480,1855,0.8574769710522535,-0.22183016901864225,0.1320435243972724,0.8792828923555086,0.38252323417346973,0.41734218098911025,2523]
["O15381-1","Nuclear valosin-containing protein-like [OS=Homo sapiens]",26,17,29,17,856,95,6.48,88.47,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","NVL","ENSG00000143748","Ribosome biogenesis in eukaryotes","","",2130.3,2080.6,2107,2484.4,2531,3403.3,0.7504602848420777,-0.41415236998005467,0.07932517141532064,1.1005889807510618,0.30660374292679987,0.5134225477121286,1891]
["O15382","Branched-chain-amino-acid aminotransferase, mitochondrial [OS=Homo sapiens]",49,14,34,14,392,44.3,8.65,113.66,"other metabolic processes;other biological processes","mitochondrion","other molecular function","BCAT2","ENSG00000105552","Cysteine and methionine metabolism; Valine, leucine and isoleucine degradation; Valine, leucine and isoleucine biosynthesis; Pantothenate and CoA biosynthesis; Metabolic pathways; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids; Biosynthesis of cofactors","Branched-chain amino acid catabolism","One-carbon metabolism and related pathways",4830.8,4755.3,5040.6,3826.9,4035.9,4161,1.2164789833496898,0.2827113955915119,2.5854090540809224E-3,2.587470734629676,0.06449404360504253,1.1904803930998122,293]
["O15397-1","Importin-8 [OS=Homo sapiens]",10,8,19,7,1037,119.9,5.16,63.01,"transport;signal transduction","cytosol;nucleus","other molecular function","IPO8","ENSG00000133704","Nucleocytoplasmic transport","Transcriptional regulation by small RNAs","",1033.4,978.8,918,1148.4,1290,1524.3,0.7394453276806218,-0.4354846120658925,0.039777781362356095,1.4003594436589628,0.21876283218770556,0.6600264627177218,1329]
["O15400","Syntaxin-7 [OS=Homo sapiens]",62,11,84,11,261,29.8,5.55,223.5,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","STX7","ENSG00000079950","SNARE interactions in vesicular transport; Phagosome","","",4585.5,4407.2,4155.6,4546.6,5216.7,6621.1,0.8024889529064232,-0.31744656271076144,0.1588363855389471,0.7990500042469774,0.4152128547582848,0.38172920943664823,2796]
["O15427","Monocarboxylate transporter 4 [OS=Homo sapiens]",3,2,4,2,465,49.4,7.96,10.11,"transport","plasma membrane;other membranes;nucleus;other cell component","transporter activity","SLC16A3","ENSG00000141526","Central carbon metabolism in cancer","Pyruvate metabolism; Basigin interactions; Proton-coupled monocarboxylate transport","Metabolic reprogramming in colon cancer",571.4,540.9,466.8,476.6,468.5,567.5,1.0439640354356736,0.06207201191514819,0.6438464204876198,0.1912177144555585,0.7699400339240858,0.11354309813921906,6112]
["O15439-1","multidrug resistance-associated protein 4 [OS=Homo sapiens]",8,7,13,6,1325,149.4,8.19,35.69,"cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes","transporter activity;other molecular function","ABCC4","ENSG00000125257","Antifolate resistance; ABC transporters; cAMP signaling pathway; Bile secretion","ABC-family proteins mediated transport; Platelet degranulation","Fluoropyrimidine activity; Drug induction of bile acid pathway; Ectoderm differentiation; Pregnane X receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; TYROBP causal network in microglia; Aspirin and miRNAs; Proximal tubule transport; FOXA2 pathway; Prostaglandin synthesis and regulation",524,479.7,465.5,425.6,426.8,604.3,1.0085810393354844,0.012327008938718917,0.9495843850947114,0.022466435505612378,0.967453620108342,0.014369845961587222,7174]
["O15446-1","DNA-directed RNA polymerase I subunit RPA34 [OS=Homo sapiens]",17,3,3,3,510,55,8.51,13.7,"RNA metabolism OR transcription;other metabolic processes;signal transduction","cytosol;mitochondrion;nucleus;other cell component","other molecular function","POLR1G","ENSG00000117877","RNA polymerase","B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","",53.7,58,59,66.1,46,54.9,1.0221556886227545,0.03161495566632357,0.8481214630473969,0.07154194614690401,0.9035009143584644,0.044071403589341966,6861]
["O15498","Synaptobrevin homolog YKT6 [OS=Homo sapiens]",38,8,44,8,198,22.4,6.92,123.61,"cell organization and biogenesis;transport","plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","YKT6","ENSG00000106636","SNARE interactions in vesicular transport","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; COPI-mediated anterograde transport; RAC3 GTPase cycle; Intra-Golgi traffic; COPII-mediated vesicle transport","",7826,7677.8,7199.8,5781,6097,5020.4,1.3435354826492447,0.42603442329832647,6.4573940483872985E-3,2.1899427109120184,0.09731359401992323,1.0118264876303094,485]
["O15504","nucleoporin-like protein 2 [OS=Homo sapiens]",7,2,4,2,423,44.8,9.19,8.16,"transport","other membranes;cytosol;nucleus","other molecular function","NUP42","ENSG00000136243","Nucleocytoplasmic transport","HCMV Early Events; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus","",173.1,190.6,173.3,204.4,190.6,228.6,0.8611289288005132,-0.21569883982500973,0.08257958364635036,1.0831273111022515,0.31257078035793623,0.5050516229976731,1931]
["O15511-1","Actin-related protein 2/3 complex subunit 5 [OS=Homo sapiens]",58,9,39,9,151,16.3,5.67,142.68,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity","Arpc5; ARPC5","ENSDLEG00000020693; ENSG00000162704; ENSGGOG00000007894; ENSPCTG00005002795; ENSPPAG00000038421; ENSPPYG00000000425; ENSPTRG00000001767; ENSRNOG00000028062; ENSSBOG00000027275; ENSSSCG00000015560; ENSSSCG00070012419; ENSSTOG00000001001","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection","Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; EPHB-mediated forward signaling; Neutrophil degranulation; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling","Pathogenic Escherichia coli infection; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton",4240.6,3916.9,4205.8,4410.4,4453.8,3513.1,0.9988688970938732,-1.6327601374496372E-3,0.9891745864153781,0.004727049934420941,0.9943442514248382,2.463232694313284E-3,7271]
["O15527-1","N-glycosylase/DNA lyase [OS=Homo sapiens]",3,1,1,1,345,38.8,8.6,3.08,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","OGG1","ENSG00000114026","Base excision repair","Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Displacement of DNA glycosylase by APEX1; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; Defective OGG1 Substrate Binding; Defective OGG1 Substrate Processing","Base excision repair; DNA repair pathways, full network",106.6,131.5,84.9,121,102,130.6,0.9134615384615384,-0.13058410981014437,0.5553995097155755,0.25539450796335234,0.7073383893554873,0.15037277082633763,5739]
["O15530-1","3-phosphoinositide-dependent protein kinase 1 [OS=Homo sapiens]",25,10,18,10,556,63.1,7.36,46.45,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function","PDPK1","ENSG00000140992","Platinum drug resistance; PPAR signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Apoptosis; Axon guidance; Focal adhesion; T cell receptor signaling pathway; Fc epsilon RI signaling pathway; Neurotrophin signaling pathway; Insulin signaling pathway; Thyroid hormone signaling pathway; Insulin resistance; Aldosterone-regulated sodium reabsorption; Toxoplasmosis; Proteoglycans in cancer; Chemical carcinogenesis; Endometrial cancer; Prostate cancer; Non-small cell lung cancer; Choline metabolism in cancer; Lipid and atherosclerosis","Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of TP53 Degradation; PIP3 activates AKT signaling; GPVI-mediated activation cascade; CD28 dependent PI3K/Akt signaling; G beta:gamma signalling through PI3Kgamma; RHO GTPases activate PKNs; Activation of AKT2; Integrin signaling; RSK activation; VEGFR2 mediated vascular permeability; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ","MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac hypertrophic response; Focal adhesion; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; PPAR signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; EGF/EGFR signaling pathway; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Modulators of TCR signaling and T cell activation; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway",2229.9,2272.5,2193.2,1819.7,1788.2,2346.4,1.1244982617604082,0.16928143101205956,0.24716508292416262,0.6070128821448795,0.5061724827942574,0.2957014682165669,3569]
["O15533-1","Tapasin [OS=Homo sapiens]",11,5,40,5,448,47.6,7.15,107.11,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;ER/Golgi","signal transduction activity or receptor binding;transporter activity;other molecular function","TAPBP","ENSG00000112493; ENSG00000206208; ENSG00000206281; ENSG00000231925; ENSG00000236490; ENSPPAG00000024524; ENSPTRG00000018043","Antigen processing and presentation; Human cytomegalovirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection","ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC","",4937.1,4750.7,4858.8,4419.3,4543.7,7375.9,0.890304732876754,-0.16762886963726117,0.5701240408186727,0.2440306454109623,0.7153710925911896,0.1454686132250459,5825]
["O15534-1","period circadian protein homolog 1 [OS=Homo sapiens]",2,2,2,2,1290,136.1,6.09,0,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PER1","ENSG00000179094","Circadian rhythm; Circadian entrainment","Circadian Clock","Melatonin metabolism and effects; Exercise-induced circadian regulation",190.4,170.1,207,132.4,132.6,290.1,1.0223383174202847,0.031872699304057214,0.9422421584857525,0.025837468142658953,0.9627915470952559,0.01646773130311635,7153]
["O15541","RING finger protein 113A [OS=Homo sapiens]",29,7,14,7,343,38.8,5.69,43.22,"protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus","other molecular function","RNF113A","ENSG00000125352","","","",1398.3,1278.4,1216,1317.8,1347.3,1185,1.011064647671489,0.015875246393496963,0.8555655182665879,0.06774672705553005,0.9091783037235376,0.041350936657551705,6878]
["O15550","Lysine-specific demethylase 6A [OS=Homo sapiens]",3,4,5,4,1401,154.1,7.44,12.76,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","KDM6A","ENSG00000147050","Transcriptional misregulation in cancer","Activation of anterior HOX genes in hindbrain development during early embryogenesis; HDMs demethylate histones","Mesodermal commitment pathway; Mesodermal commitment pathway; Pathways affected in adenoid cystic carcinoma",647.3,638.4,638.6,676.6,656.1,724.5,0.9353976278436711,-0.09634832478189975,0.09653010403510565,1.015337225749726,0.33295824935940876,0.4776102205765476,2119]
["O15553","Pyrin [OS=Homo sapiens]",2,2,5,1,781,86.4,8.03,11.75,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","MEFV","ENSG00000103313","NOD-like receptor signaling pathway; Yersinia infection","The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection","Nucleotide-binding oligomerization domain (NOD) pathway",233.2,223.4,207.4,254.3,282.6,239.4,0.8553394306324873,-0.2254310459850272,0.06392157275963942,1.1943525479551766,0.2728988173482503,0.5639983464123381,1712]
["O43143","Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 [OS=Homo sapiens]",41,32,171,32,795,90.9,7.46,501.7,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","DHX15","ENSG00000109606","Spliceosome","mRNA Splicing - Major Pathway","mRNA processing",19677.8,19266,19982,18872.9,18753.7,13842.8,1.1448705444399971,0.1951844756556702,0.21092298563829626,0.6758760898104204,0.47015434645633036,0.32775954459581264,3279]
["O43148-1","mRNA cap guanine-N7 methyltransferase [OS=Homo sapiens]",41,18,47,18,476,54.8,6.61,140.64,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RNMT","ENSG00000101654","mRNA surveillance pathway","RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE","mRNA processing",5592,5509.2,5415.7,6097.7,6281.2,4832.5,0.9596488373984685,-0.059421515330496166,0.6399920612169174,0.19382541318965912,0.7674654594642246,0.11494116126008694,6095]
["O43149","Zinc finger ZZ-type and EF-hand domain-containing protein 1 [OS=Homo sapiens]",14,33,57,21,2961,330.9,5.95,161.32,"","","other molecular function","ZZEF1","ENSG00000074755","","","",4892.4,4967.7,4963.4,4537.7,4605.1,6038.2,0.9764508266912587,-0.034380701952898586,0.8197897040800618,0.08629754038557487,0.8874174980925906,0.051872012119200527,6752]
["O43149-3","Isoform 3 of Zinc finger ZZ-type and EF-hand domain-containing protein 1 [OS=Homo sapiens]",13,13,25,1,1085,119.9,5.67,74.37,"","","","ZZEF1","","","","",306.1,276.7,317.7,287.9,288.2,382.2,0.9396848586037776,-0.08975109252186522,0.5978183283998093,0.22343077413970036,0.7378342050446144,0.13204121530900775,5922]
["O43150-1","Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 [OS=Homo sapiens]",4,3,4,3,1006,111.6,6.68,13.77,"other biological processes","plasma membrane;other membranes;ER/Golgi","enzyme regulator activity;other molecular function","ASAP2","ENSG00000151693","Endocytosis; Fc gamma R-mediated phagocytosis","","Vitamin D receptor pathway",115.4,106.9,108.4,96.9,128.8,152.6,0.8741739360296062,-0.19400773085826106,0.3867021422305741,0.412623422040355,0.6002136244559919,0.22169415059910452,4709]
["O43156","TELO2-interacting protein 1 homolog [OS=Homo sapiens]",7,7,9,7,1089,122,5.97,19.69,"other biological processes","nucleus;other cell component","","TTI1","ENSG00000101407","mTOR signaling pathway","","Fragile X syndrome; Malignant pleural mesothelioma",963.9,1038,968.9,1082.4,997.3,1155.1,0.9183875355508843,-0.12282503314483695,0.16260690445285877,0.7888610177695327,0.4196659126574664,0.3770963049032911,2832]
["O43159","ribosomal rna-processing protein 8 [OS=Homo sapiens]",19,8,22,8,456,50.7,9.42,54.26,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","RRP8","ENSG00000132275","","SIRT1 negatively regulates rRNA expression","",1921.3,1892.1,1832.5,2255.8,2264.5,1651.7,0.9147602073882046,-0.1285344858631127,0.4395064140480444,0.35703478255756727,0.6288865270707041,0.20142770926497197,5108]
["O43164","E3 ubiquitin-protein ligase Praja-2 [OS=Homo sapiens]",3,1,2,1,708,78.2,4.39,6.64,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component","other molecular function","PJA2","ENSG00000198961","","Antigen processing: Ubiquitination & Proteasome degradation","",67.8,58.5,59.6,84.8,77.9,81.1,0.7625102543068089,-0.3911713557007305,0.005539368608271667,2.256539734472026,0.09180781214933699,1.0371203620558915,441]
["O43166-1","Signal-induced proliferation-associated 1-like protein 1 [OS=Homo sapiens]",1,2,2,2,1804,199.9,8.19,0,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;enzyme regulator activity","SIPA1L1","ENSG00000197555","Rap1 signaling pathway","Neurexins and neuroligins","",99.6,90.2,90.8,92.2,93.8,278.1,0.6046110751993105,-0.7259206885502928,0.37815995551919235,0.4223244617887327,0.5952985386366093,0.22526518357093375,4643]
["O43169","Cytochrome b5 type B [OS=Homo sapiens]",55,5,29,5,146,16.3,4.97,98.99,"","other membranes","other molecular function","","","","","",2279,3294.5,3574.8,2621.4,2054.7,2395.4,1.2936859223644204,0.3714874061663733,0.18003787999937867,0.7446361096526447,0.4376111955156165,0.3589115758691892,3007]
["O43172-1","U4/U6 small nuclear ribonucleoprotein Prp4 [OS=Homo sapiens]",43,19,56,1,522,58.4,7.42,166.66,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity","PRPF4","ENSG00000136875; ENSPTRG00000021274","Spliceosome","mRNA Splicing - Major Pathway","mRNA processing; mRNA Processing",148.2,157.2,161.1,171.4,201.6,210.2,0.7998971193415637,-0.32211363858781616,0.034685601428750955,1.459850770677977,0.20577683509962721,0.6866035166224108,1232]
["O43172-2","Isoform 2 of U4/U6 small nuclear ribonucleoprotein Prp4 [OS=Homo sapiens]",43,19,57,1,521,58.3,7.42,168.72,"","","","PRPF4","","","","",7072.2,6776.1,6817.2,7079.9,7108.6,7296.6,0.9618526327547929,-0.05611222197302166,0.07612817013570777,1.1184546090549168,0.30141971588401306,0.520828343860837,1846]
["O43175","D-3-phosphoglycerate dehydrogenase [OS=Homo sapiens]",43,18,195,18,533,56.6,6.71,658.6,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytosol","other molecular function","PHGDH","ENSG00000092621","Glycine, serine and threonine metabolism; Cysteine and methionine metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids","Serine biosynthesis","Trans-sulfuration and one-carbon metabolism; Clear cell renal cell carcinoma pathways; Neuroinflammation and glutamatergic signaling",14315.2,13345.5,14272.8,15590.3,16148.3,18313.5,0.8377970155098388,-0.25532734999639506,0.03821452004474284,1.4177715905662165,0.21501918938185177,0.6675227797552713,1299]
["O43181","NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [OS=Homo sapiens]",23,4,8,4,175,20.1,10.3,15.99,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity","NDUFS4","ENSG00000164258","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",1090.3,1015.3,1064.3,1026.4,1052,514.3,{"$f":"AVERAGE(S322:U322)/AVERAGE(V322:X322)","v":1.222625062675975},{"$f":"LOG(Y322,2)","v":0.2899820464242443},{"$f":"TTEST(V322:X322,S322:U322,2,2)","v":0.33693861172355954},0.47244921787722866,{"$f":"AA322*7309/AE322","v":0.5752591247576493},0.2401364838275651,4281]
["O43182","Rho GTPase-activating protein 6 [OS=Homo sapiens]",7,6,7,6,974,105.9,7.36,16.39,"cell adhesion;cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","ARHGAP6","ENSG00000047648","","RHOA GTPase cycle; RAC3 GTPase cycle","",362.5,349.9,351.7,395,386,383.3,0.913939706261273,-0.12982910285025928,3.2196347527298635E-3,{"$f":"-LOG10(AA323)","v":2.4921933934815312},0.07066759882192965,{"$f":"-LOG10(AC323)","v":1.1507796651038782},333]
["O43189-2","Isoform 1 of PHD finger protein 1 [OS=Homo sapiens]",18,5,10,5,457,49.6,7.93,27.84,"","","","PHF1","","","","",607.5,590.9,596.8,557.8,567.8,885,0.8928678006565205,-0.1634815113168343,0.5409289760149039,0.2668597540241464,0.6953306165481766,0.1578086474945968,5686]
["O43237","Cytoplasmic dynein 1 light intermediate chain 2 [OS=Homo sapiens]",18,7,14,7,492,54.1,6.38,47.14,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","DYNC1LI2","ENSG00000135720","Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection","Separation of Sister Chromatids; COPI-mediated anterograde transport; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Intraflagellar transport proteins binding to dynein",1353.7,1387.5,1310.6,1491.6,1411.1,1674.7,0.8851749901690916,-0.1759654052359506,0.09687152873081448,1.0138038466024104,0.33334934251107484,0.47710039712786895,2124]
["O43242","26S proteasome non-ATPase regulatory subunit 3 [OS=Homo sapiens]",57,29,211,29,534,60.9,8.44,648.47,"protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","enzyme regulator activity","PSMD3","ENSG00000108344","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Interleukin-1 signaling; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease",20037,20809.6,20003.9,20029,19359.3,19592,1.031708892630251,0.04503595680392859,0.13046122915948774,0.8845185340254875,0.38080715811769006,0.4192948966799066,2504]
["O43251-1","RNA binding protein fox-1 homolog 2 [OS=Homo sapiens]",2,1,1,1,390,41.3,7.27,2.16,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RBFOX2","ENSG00000100320; ENSG00000277564","","FGFR2 alternative splicing","Mammalian disorder of sexual development",55.6,68.4,52.8,70.1,58.5,752,0.20077220077220076,-2.316368569545462,0.36410705184592557,0.438770909783125,0.5891650303169957,0.22976303846054624,4517]
["O43252","bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [OS=Homo sapiens]",52,24,106,22,624,70.8,6.86,321.71,"other metabolic processes;developmental processes","cytosol","kinase activity;other molecular function","PAPSS1","ENSG00000138801","Purine metabolism; Selenocompound metabolism; Sulfur metabolism; Metabolic pathways","Signaling by BRAF and RAF1 fusions; Transport and synthesis of PAPS; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se","Sulfation biotransformation reaction",11412.2,11223.3,11290.7,11694.8,11725.5,12200.6,0.952423998270678,-0.07032412216875723,0.030816001447700032,1.5112237141529077,0.19619699876414595,0.7073076403308893,1148]
["O43264","Centromere/kinetochore protein zw10 homolog [OS=Homo sapiens]",36,19,56,19,779,88.8,6.27,186.12,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","nucleic acid binding activity","ZW10","ENSG00000086827","","COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",3051.1,3059.7,3111,2982.9,3055.2,1988.2,1.1489478339957389,0.20031329637902887,0.31206743806732534,0.5057515443927701,0.5591813936832756,0.2524472878258918,4079]
["O43278","Kunitz-type protease inhibitor 1 [OS=Homo sapiens]",17,9,13,9,529,58.4,6.29,35.9,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes","enzyme regulator activity","SPINT1","ENSG00000166145","Transcriptional misregulation in cancer; Prostate cancer","MET Receptor Activation; Signaling by MST1","",1592.7,1537.9,1642.7,1451.6,1433.4,3188.7,0.7858965704595223,-0.34758863876953944,0.49838610069812467,0.30243407805490463,0.6670397381436721,0.17584829270647503,5461]
["O43283","Mitogen-activated protein kinase kinase kinase 13 [OS=Homo sapiens]",2,1,1,1,966,108.2,6.49,0,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;other cell component","kinase activity;other molecular function","MAP3K13","ENSG00000073803","MAPK signaling pathway","","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Insulin signaling",284.2,274.1,271.8,203.3,270.6,49.8,1.5850677869008971,0.6645445398817595,0.19366187533388995,0.7129558669513275,0.4517952910358767,0.34505829994905973,3133]
["O43290","U4/U6.U5 tri-snRNP-associated protein 1 [OS=Homo sapiens]",56,39,111,39,800,90.2,6.13,371.13,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","","SART1","ENSG00000175467","Spliceosome","mRNA Splicing - Major Pathway","",11057.5,10875.2,10618.1,11840.3,12343.4,13451.8,0.8648961751537778,-0.20940113737602536,0.026306789169991143,1.5799321557474424,0.18417272226385561,0.7347746925297128,1044]
["O43291","Kunitz-type protease inhibitor 2 [OS=Homo sapiens]",13,3,3,3,252,28.2,8.29,4.49,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","enzyme regulator activity","SPINT2","ENSG00000167642","","MET Receptor Activation; Signaling by MST1","",387.1,396,372.7,385.9,378.6,1264.5,0.5696402168555939,-0.8118770900684187,0.37845289406775295,0.42198816931999394,0.5952468695375954,0.22530287991488948,4647]
["O43292-1","Glycosylphosphatidylinositol anchor attachment 1 protein [OS=Homo sapiens]",10,6,10,6,621,67.6,8.06,27.83,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi","cytoskeletal activity","GPAA1","ENSG00000197858","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways","Attachment of GPI anchor to uPAR","",1467,1396.3,1499.9,1107.1,1215.3,1366.1,1.1829198861325747,0.24235236971066298,0.05014217717044963,1.2997968129269717,0.24465231838372253,0.6114506644064465,1498]
["O43298","Zinc finger and BTB domain-containing protein 43 [OS=Homo sapiens]",2,1,1,1,467,52.6,5.76,2.49,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB43","ENSG00000169155","","","",72.9,45.7,39.7,37.7,57.2,0.6,1.6575916230366494,0.7290886172140704,0.3432976041585697,0.46432922746368616,0.5782812142878511,0.2378609157089251,4339]
["O43299","AP-5 complex subunit zeta-1 [OS=Homo sapiens]",3,2,2,2,807,88.5,7.01,4.08,"DNA metabolism;stress response;transport","other membranes;nucleus;other cell component","","AP5Z1","ENSG00000242802","","","",115.9,159.9,127.3,143.6,110.1,1476.2,0.23301924966761087,-2.101478954373151,0.38141923679579715,0.4185974071904232,0.5969578590450709,0.2240563258725624,4670]
["O43301","Heat shock 70 kDa protein 12A [OS=Homo sapiens]",2,1,4,1,675,74.9,6.77,0,"","nucleus;other cell component","other molecular function","HSPA12A","ENSG00000165868","","Regulation of HSF1-mediated heat shock response","",324.5,142.1,557.5,72.2,126.1,3.4,5.077342588001982,2.3440736075831294,0.09400535110553705,1.026847424171984,0.3289062284491959,0.48292790226831966,2089]
["O43303","centriolar coiled-coil protein of 110 kDa [OS=Homo sapiens]",12,9,9,8,1012,113.4,8.65,21.8,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;other cell component","","CCP110","ENSG00000103540","","Ub-specific processing proteases; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; RHOV GTPase cycle","Genotoxicity pathway; Joubert syndrome",605.3,578.2,632,722.8,782.8,808.7,0.7844704662316898,-0.35020896129899604,0.005062927989567165,2.295598249574649,0.08707044864881508,1.0601292177409876,425]
["O43310","CBP80/20-dependent translation initiation factor [OS=Homo sapiens]",15,6,7,1,598,67.5,6.54,17.4,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity","CTIF","ENSG00000134030; ENSG00000282825","","","",402.5,443.7,367.7,489.9,442.7,1097.1,0.5980686801005076,-0.741616926933985,0.2685910585068878,0.5709084492464365,0.5235018791004915,0.28108175509018235,3750]
["O43310-2","Isoform 2 of CBP80/20-dependent translation initiation factor [OS=Homo sapiens]",15,6,7,1,600,67.7,6.54,15.96,"","","","CTIF","","","","",34.5,30.9,22.3,38,23.5,210.6,0.3223079750091878,-1.6334882088049456,0.3649967185130603,0.43771104003140643,0.5894301846248249,0.2295676277661433,4526]
["O43314-1","inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 [OS=Homo sapiens]",15,16,30,13,1243,140.3,8.22,88.09,"other metabolic processes;other biological processes","cytosol","kinase activity;other molecular function","PPIP5K2","ENSG00000145725","Phosphatidylinositol signaling system","Synthesis of pyrophosphates in the cytosol","",2837.1,2699.1,2859.6,2710.5,2746.6,2651.8,1.0353808778009348,0.050161578771673,0.17029327782870327,0.7688024950762726,0.42669645788481053,0.3698809623140323,2917]
["O43318","mitogen-activated protein kinase kinase kinase 7 [OS=Homo sapiens]",3,2,2,2,606,67.2,7.11,3.79,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle","signal transduction activity or receptor binding;kinase activity;other molecular function","MAP3K7","ENSG00000135341","MAPK signaling pathway; NF-kappa B signaling pathway; Autophagy; AMPK signaling pathway; Wnt signaling pathway; Osteoclast differentiation; Adherens junction; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; IL-17 signaling pathway; T cell receptor signaling pathway; TNF signaling pathway; Alcoholic liver disease; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Leishmaniasis; Toxoplasmosis; Hepatitis B; Measles; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Ca2+ pathway; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; TNFR1-induced NFkappaB signaling pathway; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway","Regulation of toll-like receptor signaling pathway; IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; Fas ligand pathway and stress induction of heat shock proteins; Wnt signaling pathway; IL-6 signaling pathway; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Angiopoietin-like protein 8 regulatory pathway; Wnt signaling pathway and pluripotency; p38 MAPK signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; miRNAs involvement in the immune response in sepsis; Signal transduction through IL1R; Hepatitis B infection; IL-18 signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - interferon induction; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway",113,126,114,141.2,128.3,97.7,0.9613289760348585,-0.05689787525526522,0.7446146049028863,0.1280684497634396,0.8360043236920424,0.0777914764476586,6510]
["O43324-1","Eukaryotic translation elongation factor 1 epsilon-1 [OS=Homo sapiens]",53,8,37,8,174,19.8,8.54,111.53,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","EEF1E1","ENSANAG00000036153; ENSG00000124802; ENSPTRG00000017709","","Selenoamino acid metabolism; Cytosolic tRNA aminoacylation","",4074.2,4305.3,5164.9,5300,5283.6,2630.4,1.025003783865597,0.03562923553955656,0.9130378575577146,0.03951121481230209,0.943235858782945,0.025379697124656975,7075]
["O43353-1","Receptor-interacting serine/threonine-protein kinase 2 [OS=Homo sapiens]",10,4,5,4,540,61.2,7.09,10.76,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","RIPK2","ENSG00000104312","NOD-like receptor signaling pathway; Neurotrophin signaling pathway; Shigellosis; Salmonella infection; Tuberculosis","Downstream TCR signaling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; p75NTR recruits signalling complexes; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; activated TAK1 mediates p38 MAPK activation; Ovarian tumor domain proteases","Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Fas ligand pathway and stress induction of heat shock proteins; T-cell receptor (TCR) signaling pathway",243.5,245.3,230,260.4,227.8,276.2,0.9403453689167975,-0.08873736946751463,0.36951135251050526,0.4323722142192772,0.5921417398595227,0.22757432457624255,4561]
["O43379-4","Isoform 4 of WD repeat-containing protein 62 [OS=Homo sapiens]",7,10,16,10,1523,166.4,5.88,35.16,"","","","WDR62","","","","",1291.7,1256.4,1189.5,1240.3,1151.1,1239.4,1.0294150049575852,0.04182471681982691,0.44550516824463543,0.3511472534068888,0.6325169531274359,0.19892782975526493,5148]
["O43390-1","heterogeneous nuclear ribonucleoprotein r [OS=Homo sapiens]",58,32,239,23,633,70.9,8.13,774.29,"RNA metabolism OR transcription;other metabolic processes;other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity","Hnrnpr; HNRNPR; LOC111154612","ENSAMEG00000009537; ENSCAFG00000013308; ENSCANG00000026442; ENSCATG00000035305; ENSFCAG00000019123; ENSG00000125944; ENSG00000282958; ENSGGOG00000013250; ENSLCNG00005013650; ENSMFAG00000039737; ENSMMUG00000010970; ENSMPUG00000015898; ENSNLEG00000008411; ENSRROG00000036942; ENSSSUG00005005658; ENSUAMG00000027050; ENSUMAG00000013292","","mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA","mRNA Processing; mRNA processing",24519.9,26143.1,25097,30181.9,28766.6,24215.1,0.9109754748471687,-0.13451588036897308,0.25560364362984894,0.5924329596018267,0.5122585772664014,0.29051076103163503,3647]
["O43395","U4/U6 small nuclear ribonucleoprotein Prp3 [OS=Homo sapiens]",42,24,72,24,683,77.5,9.5,192.25,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","other molecular function","PRPF3","ENSG00000117360","Spliceosome","mRNA Splicing - Major Pathway","mRNA processing",8128,8335.4,7885.3,9392.2,9415.7,8312.7,0.8977935591395471,-0.15554434863475775,0.07505027440505721,1.1246477155141914,0.29942273778742534,0.5237152229620499,1832]
["O43396","Thioredoxin-like protein 1 [OS=Homo sapiens]",59,13,79,13,289,32.2,4.96,327.32,"","cytosol;nucleus;other cell component","other molecular function","TXNL1","ENSG00000091164","","RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle","",9715,9333,9422.1,8421.9,8617.9,6289.4,1.2203633215026664,0.28731072491661563,0.08561953018841832,1.0674271595563374,0.31621684999855965,0.5000149918787608,1979]
["O43399","Tumor protein D54 [OS=Homo sapiens]",60,11,30,11,206,22.2,5.36,92.73,"other metabolic processes;other biological processes","other cell component","other molecular function","TPD52L2","ENSG00000101150","","","",2408.2,2303.9,3021.7,2426.5,2858.8,2903.4,0.9444478366529485,-0.08245697840110489,0.605233794753133,0.21807683004568634,0.7419748080930307,0.12961083985832533,5962]
["O43402","ER membrane protein complex subunit 8 [OS=Homo sapiens]",29,5,10,5,210,23.8,6.4,41.53,"cell organization and biogenesis","other membranes;cytosol;ER/Golgi;other cell component","","EMC8","ENSG00000131148","","","",1170.1,1107.9,1073.9,1071.4,1102,659.6,1.1831627250264736,0.2426485068510491,0.29997565455650727,0.5229139903496796,0.5499177474676478,0.25970226412810105,3987]
["O43414-1","ERI1 exoribonuclease 3 [OS=Homo sapiens]",3,1,3,1,337,37.2,8.07,8.56,"RNA metabolism OR transcription;other metabolic processes","","nucleic acid binding activity;other molecular function","ERI3","ENSG00000117419; ENSMFAG00000044436; ENSMLEG00000012810; ENSMMUG00000011651; ENSMNEG00000035539; ENSNLEG00000014004; ENSPANG00000013867; ENSPPAG00000042776; ENSPTRG00000000655; ENSRBIG00000044795; ENSRROG00000036414","","","",616.7,640,604.8,629.2,593.6,494.2,1.084158415841584,0.11657557684937847,0.31233753477143317,0.5053758218390012,0.5593910908219566,0.25228445472829913,4081]
["O43422-1","52 kDa repressor of the inhibitor of the protein kinase [OS=Homo sapiens]",16,7,11,7,761,87.6,5.86,27.98,"other metabolic processes;signal transduction;other biological processes","","nucleic acid binding activity;kinase activity;other molecular function","THAP12","ENSG00000137492; ENSPTRG00000004091","","","",478.8,383.6,463.2,363.3,392,274.4,1.2873652520151504,0.364421433909018,0.09896777757329783,1.0045061821699766,0.33613173154425363,0.47349048728035525,2152]
["O43426","Synaptojanin-1 [OS=Homo sapiens]",7,9,12,9,1573,173,7.42,33.23,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity;other molecular function","SYNJ1","ENSG00000159082","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; Synthesis of IP3 and IP4 in the cytosol; Synthesis of IP2, IP, and Ins in the cytosol","VEGFA-VEGFR2 signaling pathway; EGF/EGFR signaling pathway",1110.8,880.1,1015.9,1013.9,1081.3,1042.3,0.9583426294820718,-0.061386550115304916,0.5660216965577257,0.2471669212592543,0.7130390520752184,0.14688668384192663,5802]
["O43427","Acidic fibroblast growth factor intracellular-binding protein [OS=Homo sapiens]",23,9,17,9,364,41.9,6.48,41.38,"signal transduction","other membranes;mitochondrion;nucleus;other cell component","other molecular function","FIBP","ENSG00000172500","","","Modulators of TCR signaling and T cell activation",2172.2,2165.2,2025,2162.2,2092.2,1377.9,1.129627328089768,0.1758468960080984,0.3941513299323294,0.40433700371660514,0.603446181498826,0.2193614565033679,4774]
["O43432","Eukaryotic translation initiation factor 4 gamma 3 [OS=Homo sapiens]",15,23,56,17,1585,176.5,5.38,136.67,"protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus","nucleic acid binding activity","EIF4G3","ENSG00000075151","Viral myocarditis","ISG15 antiviral mechanism","Translation factors; Translation inhibitors in chronically activated PDGFRA cells",2343.6,2414.8,2344.1,2511.6,2561.4,2319.5,0.9607710517416301,-0.057735411930782875,0.28004659371557183,0.5527697054074086,0.5327591237551054,0.27346910404911035,3842]
["O43447","peptidyl-prolyl cis-trans isomerase H [OS=Homo sapiens]",47,8,66,7,177,19.2,8.07,156.88,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","PPIH","ENSG00000171960","Spliceosome","mRNA Splicing - Major Pathway","",5629.9,5222.4,5827.9,6010.3,6148.1,6364,0.900542046387077,-0.15113445762534103,0.04060400865476007,1.3914310883267018,0.22081450837622127,0.6559723951605352,1344]
["O43463","Histone-lysine N-methyltransferase SUV39H1 [OS=Homo sapiens]",8,3,4,3,412,47.9,8.03,9.35,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SUV39H1","ENSG00000101945","Lysine degradation; Metabolic pathways","PKMTs methylate histone lysines; SIRT1 negatively regulates rRNA expression","Histone modifications; Retinoblastoma gene in cancer; Interactions between LOXL4 and oxidative stress pathway; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome",216.7,199,185.4,263.5,291.9,215.6,0.7796368352788586,-0.3591258400807781,0.07800082968777856,1.107900777733782,0.30454490608331913,0.5163486602518955,1872]
["O43464","Serine protease HTRA2, mitochondrial [OS=Homo sapiens]",30,9,36,9,458,48.8,10.07,113.17,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","HTRA2","ENSG00000115317","Apoptosis; Apoptosis; Parkinson disease; Pathways of neurodegeneration","","Parkinson's disease pathway; Nanomaterial induced apoptosis; Ciliary landscape; Complement system in neuronal development and plasticity",2096.9,1922.8,2082.2,1957.7,2058.9,1810.7,1.0471230243852212,0.06643095157510354,0.3718681999674665,0.42961095842278996,0.5926700116795056,0.22718704693273703,4586]
["O43488","aflatoxin B1 aldehyde reductase member 2 [OS=Homo sapiens]",39,11,37,11,359,39.6,7.17,96.56,"other metabolic processes","cytosol;ER/Golgi","other molecular function","AKR7A2","ENSG00000053371","Metabolism of xenobiotics by cytochrome P450","Aflatoxin activation and detoxification","Aflatoxin B1 metabolism; Metapathway biotransformation Phase I and II",5452.9,5083.2,4921,4891.3,5124.2,4580.6,1.058988359904358,0.08268673172821875,0.26685567186270354,0.5737235620846901,0.521789220343633,0.28250489724353045,3738]
["O43491-1","band 4.1-like protein 2 [OS=Homo sapiens]",48,43,149,40,1005,112.5,5.44,466.01,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","EPB41L2","ENSG00000079819","","Neurexins and neuroligins","Splicing factor NOVA regulated synaptic proteins",16780.5,16846.1,16099.9,15141.3,15325.6,14363.1,1.109223734106625,0.14955039122641237,0.012620173770178728,1.8989346651465457,0.13158466488764098,0.8807947212292315,701]
["O43493-1","Trans-Golgi network integral membrane protein 2 [OS=Homo sapiens]",37,16,34,2,480,51.1,5.73,98.24,"","","","","","","","",4296,3558,3423.8,5425.7,5494.7,3340.7,0.7908085631543149,-0.3385996017244177,0.2592465245659325,0.5862870570101071,0.5165847459248638,0.2868584221241176,3668]
["O43493-4","Isoform 4 of Trans-Golgi network integral membrane protein 2 [OS=Homo sapiens]",44,15,33,1,379,39.5,5.59,87.4,"","","","TGOLN2","","","","",524.5,476.7,452.1,741,712.3,783,0.6498680856772348,-0.6217811943668056,9.0699328775161511E-4,3.0423959269456615,0.040921073704793545,1.3880529796043195,162]
["O43502","DNA repair protein RAD51 homolog 3 [OS=Homo sapiens]",2,1,1,1,376,42.2,6.74,2.89,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","RAD51C","ENSG00000108384","Homologous recombination; Fanconi anemia pathway","Resolution of D-loop Structures through Holliday Junction Intermediates; Factors involved in megakaryocyte development and platelet production; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Meiotic recombination","DNA repair pathways, full network",24.9,24.7,20,32.7,29.1,33.7,0.7287958115183246,-0.45641342707438276,0.01530736987463626,1.815099423740515,0.1441772763063356,0.8411031831147304,776]
["O43504","Ragulator complex protein LAMTOR5 [OS=Homo sapiens]",37,2,2,2,91,9.6,4.87,3.67,"cell organization and biogenesis;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","LAMTOR5","ENSG00000134248","mTOR signaling pathway","mTORC1-mediated signalling; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK","",58,42.5,51.9,67.9,78,54.8,0.759342301943199,-0.3971777138692948,0.11739199224230874,0.9303615269690645,0.36449365815591955,0.4383100235925074,2354]
["O43513","Mediator of RNA polymerase II transcription subunit 7 [OS=Homo sapiens]",6,1,2,1,233,27.2,5.78,6.96,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","MED7","ENSG00000155868","","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Generic Transcription Pathway","",49.9,54.1,57.1,58,63,109.3,0.6995223621363439,-0.5155579170862769,0.23380283041263053,0.6311502355815937,0.49403437047872695,0.30624283571198213,3459]
["O43521","Bcl-2-like protein 11 [OS=Homo sapiens]",15,2,2,2,198,22.2,8.21,4.69,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;other cell component","cytoskeletal activity;other molecular function","BCL2L11","ENSG00000153094","EGFR tyrosine kinase inhibitor resistance; FoxO signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Apoptosis; Non-alcoholic fatty liver disease; Epstein-Barr virus infection; Pathways in cancer; MicroRNAs in cancer; Colorectal cancer","NRAGE signals death through JNK; Signaling by BRAF and RAF1 fusions; Activation of BIM and translocation to mitochondria ; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; RUNX3 regulates BCL2L11 (BIM) transcription; FLT3 Signaling; FOXO-mediated transcription of cell death genes","Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Photodynamic therapy-induced unfolded protein response; BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Nonalcoholic fatty liver disease; EGFR tyrosine kinase inhibitor resistance; Host-pathogen interaction of human coronaviruses - apoptosis; Unfolded protein response; Galanin receptor pathway; ErbB signaling pathway; DNA damage response (only ATM dependent)",61.1,77,97.7,70.5,91,130.5,0.8075342465753426,-0.30840465078761675,0.41354730412399254,0.3834748059542266,0.615855184564438,0.21052139812522025,4908]
["O43524","Forkhead box protein O3 [OS=Homo sapiens]",11,7,16,7,673,71.2,5.16,48.59,"RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","FOXO3","ENSG00000118689","EGFR tyrosine kinase inhibitor resistance; Chemokine signaling pathway; FoxO signaling pathway; Mitophagy; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Neurotrophin signaling pathway; Prolactin signaling pathway; Alcoholic liver disease; Shigellosis; Chemical carcinogenesis; Endometrial cancer; Non-small cell lung cancer","AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of localization of FOXO transcription factors; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; MAPK6/MAPK4 signaling; Signaling by NODAL; Interleukin-4 and Interleukin-13 signaling; FOXO-mediated transcription of cell cycle genes; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; RUNX3 regulates BCL2L11 (BIM) transcription; FLT3 Signaling; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation","IL-5 signaling pathway; Energy metabolism; Glioblastoma signaling pathways; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Kit receptor signaling pathway; Copper homeostasis; NAD metabolism, sirtuins and aging; Imatinib and chronic myeloid leukemia; Pathways affected in adenoid cystic carcinoma; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Non-small cell lung cancer; Overview of leukocyte-intrinsic Hippo pathway functions; Gastrin signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; DNA damage response (only ATM dependent)",1713,1758.1,1677.1,2468.2,2578.4,2778.4,0.6579169329073482,-0.604022650816974,6.8078576031880135E-4,3.1669895367654846,0.03632016877496437,1.4398521420379182,137]
["O43566","Regulator of G-protein signaling 14 [OS=Homo sapiens]",27,12,22,1,566,61.4,8.19,49.83,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","RGS14","ENSG00000169220","Rap1 signaling pathway","G alpha (i) signalling events","Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells",1533.3,1521.9,1492.2,1507.3,1661.7,2534.2,0.797341843175761,-0.3267297135572701,0.29487859081253137,0.5303567575584114,0.5442595000628262,0.2641939815999507,3960]
["O43566-5","Isoform 3 of Regulator of G-protein signaling 14 [OS=Homo sapiens]",36,12,24,1,414,44.8,9.2,56.83,"","","","RGS14","","","","",134.4,178.8,152.1,145.3,142.3,573.5,0.5403553594239926,-0.8880196011967822,0.4108539415220894,0.3863125422717551,0.6140964127985586,0.2117634395114024,4890]
["O43567","E3 ubiquitin-protein ligase RNF13 [OS=Homo sapiens]",8,2,5,2,381,42.8,4.98,13.39,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RNF13","ENSG00000082996","","","",975.5,946.2,717.2,954.4,1071.8,408.9,1.0836926614923412,0.115955662033929,0.7728481031901823,0.1119058546309908,0.8545759131947114,0.06824935223265807,6610]
["O43572","A-kinase anchor protein 10, mitochondrial [OS=Homo sapiens]",9,4,5,4,662,73.8,6.39,16.72,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;other cell component","other molecular function","AKAP10","ENSG00000108599","","Factors involved in megakaryocyte development and platelet production","G protein signaling pathways",204.3,208.7,199.5,251.1,230,339.8,0.7461322938238517,-0.4224966430632577,0.10862116054660688,0.9640855613639143,0.3489723351363295,0.4572090004730725,2275]
["O43583","density-regulated protein [OS=Homo sapiens]",22,5,11,5,198,22.1,5.3,35.13,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","","nucleic acid binding activity","DENR","ENSG00000139726","","","",932.9,779.6,861.2,1045.8,1092.6,855.3,0.8597053813007315,-0.21808575804814104,0.17494613232441597,0.757095654374165,0.4322789997157391,0.3642358621510658,2958]
["O43592","Exportin-T [OS=Homo sapiens]",29,21,53,21,962,109.9,5.39,161.81,"transport","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","XPOT","ENSG00000184575","Nucleocytoplasmic transport","tRNA processing in the nucleus","",4452,4902.6,4881.9,4513.4,4113,6574.5,0.9365563881085989,-0.09456223614182956,0.7001472155624175,0.15481063400811282,0.8066481712713919,0.09331584643368723,6344]
["O43598-1","2'-deoxynucleoside 5'-phosphate N-hydrolase 1 [OS=Homo sapiens]",68,8,60,8,174,19.1,5.05,166.11,"other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","C6orf108; DNPH1","ENSG00000112667","","Purine catabolism","",4990.4,4699.4,5588.8,5684.6,5691.1,6981.2,0.8323082873469919,-0.26481009266763217,0.11166018369592942,0.9521016620125204,0.3546824348689909,0.45016031879719093,2301]
["O43615","Mitochondrial import inner membrane translocase subunit TIM44 [OS=Homo sapiens]",56,29,144,29,452,51.3,8.32,402.17,"cell organization and biogenesis;transport","other membranes;mitochondrion;nucleus","other molecular function","TIMM44","ENSG00000104980","","Mitochondrial protein import","",18318.5,17564.5,17966.7,17154.6,17212.4,17275.2,1.0427460487740645,0.06038784550466177,0.02894977459145412,1.5383548134242395,0.19028228641091563,0.7206016387863052,1112]
["O43617-1","Trafficking protein particle complex subunit 3 [OS=Homo sapiens]",47,9,26,9,180,20.3,4.96,60.57,"transport","other membranes;cytosol;ER/Golgi;other cell component","","TRAPPC3","ENSCANG00000028241; ENSCATG00000041647; ENSCSAG00000001096; ENSG00000054116; ENSGGOG00000004752; ENSMMUG00000022499; ENSMNEG00000014589; ENSPPAG00000041117; ENSPPYG00000001546; ENSRBIG00000043692; ENSRROG00000034420","","COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs","",5286.9,5447.7,5172.2,5092.8,5009.6,4117.2,1.1186531266702295,0.16176275301492474,0.15595039396660146,0.8070135237775976,0.41209017697103767,0.38500773766691637,2766]
["O43633","charged multivesicular body protein 2a [OS=Homo sapiens]",33,9,33,9,222,25.1,5.97,66.06,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle","other molecular function","CHMP2A","ENSG00000130724","Endocytosis; Necroptosis","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Lysosome Vesicle Biogenesis; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","",3354.2,3273.5,3454.8,3656.7,3612.8,3639.6,0.9242283964763363,-0.11367867858543633,0.006959376302229396,2.1574296800212447,0.1005258525553254,0.9977222349770707,506]
["O43639","Cytoplasmic protein NCK2 [OS=Homo sapiens]",22,8,11,7,380,42.9,6.95,32.89,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","NCK2","ENSG00000071051","ErbB signaling pathway; Axon guidance; T cell receptor signaling pathway; Pathogenic Escherichia coli infection","RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; Downstream signal transduction; VEGFA-VEGFR2 Pathway; Ephrin signaling; Activation of RAC1; Regulation of cortical dendrite branching","Pathogenic Escherichia coli infection; Brain-derived neurotrophic factor (BDNF) signaling pathway; EGF/EGFR signaling pathway; Genes controlling nephrogenesis; ErbB signaling pathway",910.5,912.6,859.7,1010.2,1007.6,874.6,0.9275342276310332,-0.10852757420789758,0.21919367113729601,0.6591719895573274,0.4799540270648582,0.3188003600165823,3338]
["O43660-1","Pleiotropic regulator 1 [OS=Homo sapiens]",37,13,23,13,514,57.2,9.17,85.7,"RNA metabolism OR transcription;other metabolic processes;other biological processes","other membranes;nucleus;other cell component","","PLRG1","ENSG00000171566","Spliceosome","mRNA Splicing - Major Pathway","",2100.9,2130.1,2266.1,2478.4,2522.9,2725.3,0.8408743820050217,-0.2500378021293715,0.010978368867005766,1.9594621812594624,0.12518080818868196,0.9024622488943069,641]
["O43663-1","Protein regulator of cytokinesis 1 [OS=Homo sapiens]",25,12,17,12,620,71.6,6.68,47.23,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","PRC1","ENSG00000198901","","RHO GTPases activate CIT","",1122.7,1342.3,1282.4,1730.3,1321.3,1622.7,0.80170292878078,-0.31886035019065095,0.09008822512595602,1.0453319692540335,0.32372410887198255,0.48982495595678627,2034]
["O43670-1","BUB3-interacting and GLEBS motif-containing protein ZNF207 [OS=Homo sapiens]",13,6,33,6,478,50.7,9.1,112.27,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","LOC111151255; Znf207; ZNF207","ENSAMEG00000005671; ENSANAG00000033773; ENSCANG00000036057; ENSCJAG00000014376; ENSECAG00000017464; ENSG00000010244; ENSGGOG00000024003; ENSMFAG00000001904; ENSMLEG00000018149; ENSMMUG00000016875; ENSMNEG00000041308; ENSNLEG00000005954; ENSOCUG00000008195; ENSPCOG00000020744; ENSPPAG00000032098; ENSPTRG00000008989; ENSRROG00000037743; ENSSBOG00000026038; ENSSTOG00000000712","","","",3655.8,3520.1,3448.3,3916.2,4030.8,4956,0.8233899093234132,-0.2803523264058261,0.08580237644841493,1.0665006834317097,0.31593429192013334,0.5004032326468706,1985]
["O43674-1","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [OS=Homo sapiens]",25,6,26,6,189,21.7,9.63,70.78,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB5","ENSG00000136521; ENSGGOG00000005222; ENSPTRG00000015649","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",3250.3,3262.2,3296.6,3228.6,3310.1,1843.9,1.1701739317156967,0.226722984316313,0.37429318679916435,0.4267880782087344,0.5936868277593516,0.22644258673991707,4608]
["O43676","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [OS=Homo sapiens]",11,1,5,1,98,11.4,9.2,14.66,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity","NDUFB3","ENSG00000119013","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease",586,542.3,630.5,759.8,804.6,422.1,0.8853762899572112,-0.17563735576281397,0.5717263631315082,0.24281178137578818,0.7166434553469719,0.14469686091285963,5831]
["O43678","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [OS=Homo sapiens]",29,2,3,2,99,10.9,9.57,10.45,"cell organization and biogenesis;other metabolic processes;transport;developmental processes","other membranes;mitochondrion","transporter activity","NDUFA2","ENSG00000131495","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",164.1,168.7,169.1,198.6,191.7,230.1,0.8089941972920697,-0.3057987402765819,0.02960740176995143,1.5285997029275944,0.19252713481901693,0.7155080522766637,1124]
["O43681","ATPase ASNA1 [OS=Homo sapiens]",50,11,55,11,348,38.8,4.91,159.62,"cell organization and biogenesis;transport","ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","GET3","ENSG00000198356","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",5724.4,6308.9,6003.9,5886.9,5263,4360.5,1.162910047452032,0.2177395068594256,0.15030755302920315,0.8230191953513062,0.4046401123721716,0.3929310673921989,2715]
["O43683","Mitotic checkpoint serine/threonine-protein kinase BUB1 [OS=Homo sapiens]",14,13,24,13,1085,122.3,6.47,63.69,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","BUB1","ENSG00000169679","Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Cell cycle; ATM signaling in development and disease ; Regulation of sister chromatid separation at the metaphase-anaphase transition",1566.7,1670.7,1617.6,1320.6,1271.7,1747.3,{"$f":"AVERAGE(S386:U386)/AVERAGE(V386:X386)","v":1.1187667066089038},{"$f":"LOG(Y386,2)","v":0.1619092263874883},{"$f":"TTEST(V386:X386,S386:U386,2,2)","v":0.3270952952992713},0.485325702405925,{"$f":"AA386*7309/AE386","v":0.5696305726333986},0.24440670973344208,4197]
["O43684","Mitotic checkpoint protein BUB3 [OS=Homo sapiens]",40,11,57,11,328,37.1,6.84,184.97,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","BUB3","ENSG00000154473","Cell cycle; Human T-cell leukemia virus 1 infection","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A","Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition",4180.9,4306.9,4418.1,4480.1,4289,4940.3,0.9413905787270047,-0.08713468002871301,0.2615843904178711,{"$f":"-LOG10(AA387)","v":0.5823881753234827},0.5189794542791043,{"$f":"-LOG10(AC387)","v":0.2848498349643211},3684]
["O43707","Alpha-actinin-4 [OS=Homo sapiens]",72,59,636,38,911,104.8,5.44,2080.36,"transport;signal transduction;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function","ACTN4","ENSG00000130402; ENSG00000282844","Focal adhesion; Adherens junction; Tight junction; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Shigellosis; Amoebiasis; Viral carcinogenesis; Systemic lupus erythematosus","Platelet degranulation ; Nephrin family interactions","Arrhythmogenic right ventricular cardiomyopathy; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Striated muscle contraction pathway; Ebola virus pathway in host; Nephrotic syndrome",68225.2,70917,67100.1,64818.1,64268.4,78807.3,0.9920560401512696,-0.01150647572203324,0.915793766752939,0.038202316774706674,0.9450143500207865,0.02456159668912317,7083]
["O43708","maleylacetoacetate isomerase [OS=Homo sapiens]",5,2,4,2,216,24.2,8.54,8.57,"other metabolic processes;other biological processes","cytosol;mitochondrion","other molecular function","GSTZ1","ENSG00000100577","Tyrosine metabolism; Metabolic pathways","Regulation of pyruvate dehydrogenase (PDH) complex; Glutathione conjugation; Tyrosine catabolism","Metapathway biotransformation Phase I and II",607.7,624,591.3,585.4,583,866.6,0.8958230958230957,-0.15871423311447527,0.49661219975900983,0.3039826157864098,0.6657627600951216,0.17668050106507277,5452]
["O43709-1","Probable 18S rRNA (guanine-N(7))-methyltransferase [OS=Homo sapiens]",16,3,9,3,281,31.9,8.73,35.36,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","BUD23","ENSG00000071462; ENSGGOG00000001453","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","7q11.23 copy number variation syndrome",729.6,732,708.6,1116.2,1101.8,1123.9,0.6493910649630449,-0.6228405603129239,2.4252217296111796E-6,5.615248549208326,0.017725945621728113,1.7513905873243534,1]
["O43719","HIV Tat-specific factor 1 [OS=Homo sapiens]",66,46,151,46,755,85.8,4.4,460.43,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","","HTATSF1","ENSG00000102241","","","",15181.8,15049.8,14945.7,14812.8,15296.4,16307.7,0.9732942096520881,-0.039052122720658985,0.40633783957281394,0.39111273279917497,0.6105927774337371,0.21424833717988054,4864]
["O43739","cytohesin-3 [OS=Homo sapiens]",18,6,17,2,400,46.3,5.47,57.64,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","CYTH3","ENSG00000008256","Phospholipase D signaling pathway; Endocytosis; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection","Intra-Golgi traffic","Insulin signaling",532.8,453.7,463.2,586.6,611.6,1137.7,0.6206173209469583,-0.6882241329618076,0.17876197354646628,0.7477248593394429,0.4368342576566773,0.3596833104867881,2991]
["O43741","5'-AMP-activated protein kinase subunit beta-2 [OS=Homo sapiens]",4,1,1,1,272,30.3,6.46,2.61,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","PRKAB2","ENSG00000131791","FoxO signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Apelin signaling pathway; Tight junction; Circadian rhythm; Thermogenesis; Insulin signaling pathway; Adipocytokine signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Insulin resistance; Non-alcoholic fatty liver disease; Alcoholic liver disease; Hypertrophic cardiomyopathy","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Carnitine metabolism; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; AMPK inhibits chREBP transcriptional activation activity; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Lipophagy","AMP-activated protein kinase (AMPK) signaling; Target of rapamycin (TOR) signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Angiopoietin-like protein 8 regulatory pathway; Lipid metabolism pathway; Caloric restriction and aging; Genotoxicity pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; Malignant pleural mesothelioma",63.1,63.9,59.6,65.9,60.9,49.3,1.0596252129471888,0.08355407702054997,0.5295518692478073,0.27609149462195787,0.6868668344866412,0.16312745312011026,5635]
["O43747-1","AP-1 complex subunit gamma-1 [OS=Homo sapiens]",28,21,71,21,822,91.3,6.8,217.4,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","AP1G1","ENSCANG00000031796; ENSCCAG00000037984; ENSCJAG00000015028; ENSG00000166747; ENSGGOG00000004800; ENSMFAG00000037769; ENSMLEG00000040277; ENSMMUG00000010878; ENSMNEG00000034875; ENSPANG00000016832; ENSPPAG00000031149; ENSPTRG00000008327; ENSRBIG00000018408; ENSRROG00000025423; ENSSBOG00000025975","Lysosome; Human immunodeficiency virus 1 infection","MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression","",7300.1,7986.3,8194.2,7224.4,6492.4,4606,1.2814962778614625,0.35782928829113064,0.1056770574367973,0.9760192880955867,0.34620959785098676,0.4606608964954515,2231]
["O43752","Syntaxin-6 [OS=Homo sapiens]",49,6,22,6,255,29.2,4.93,71.86,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","STX6","ENSG00000135823","SNARE interactions in vesicular transport","Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network","",1466.3,1409.7,1517.5,1251.7,1374.4,1315.7,1.1145923182302502,0.15651611550935465,0.033143582078967025,1.4796005558726517,0.202547191818704,0.6934737736410709,1196]
["O43760","Synaptogyrin-2 [OS=Homo sapiens]",42,6,64,6,224,24.8,4.94,159.97,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","SYNGR2","ENSG00000108639","","","",5244.1,5144,5433.8,4717.2,4866.4,5040.2,1.081928089826174,0.11360461386087353,0.034054909193767545,1.467820273410979,0.20503075065671086,0.6881809982662449,1214]
["O43765","Small glutamine-rich tetratricopeptide repeat-containing protein alpha [OS=Homo sapiens]",39,11,76,11,313,34,4.87,190.79,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","SGTA","ENSG00000104969","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",8783.1,8267.8,9308.4,8752.8,9262,6439.7,1.0778915945940422,0.10821209107203131,0.5275986541131197,0.27769632099525327,0.6865263597850795,0.16334278298742264,5617]
["O43766-1","Lipoyl synthase, mitochondrial [OS=Homo sapiens]",4,2,2,2,372,41.9,8.59,4.94,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","mitochondrion","other molecular function","LIAS","ENSG00000121897","Lipoic acid metabolism; Metabolic pathways; Biosynthesis of cofactors","Glyoxylate metabolism and glycine degradation","",208.7,240.8,218.7,257.9,268.6,164.8,0.9665846955012297,-0.04903194297220945,0.8333716596746519,0.07916127260467128,0.8952253763318682,0.0480676156612297,6804]
["O43768","alpha-endosulfine [OS=Homo sapiens]",17,2,3,2,121,13.4,7.24,9.83,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","ENSA","ENSG00000143420","","MASTL Facilitates Mitotic Progression","",318.5,254,271.7,254.7,241.2,118.2,1.374694675134343,0.45911122621312217,0.1816467338323988,0.7407724067267762,0.43976680277608576,0.356777557865901,3019]
["O43772","mitochondrial carnitine/acylcarnitine carrier protein [OS=Homo sapiens]",49,14,46,14,301,32.9,9.41,134.56,"transport;developmental processes","other membranes;cytosol;mitochondrion","transporter activity","SLC25A20","ENSG00000178537","Thermogenesis","Carnitine metabolism","Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation; Thermogenesis",7431.6,7775.6,7957.2,7116.8,6572.5,5849.2,1.1855771937456818,0.24558960074350755,0.03857499485158363,1.413694123227976,0.21621521270722757,0.6651137527399045,1304]
["O43776","Asparagine--tRNA ligase, cytoplasmic [OS=Homo sapiens]",44,27,177,26,548,62.9,6.25,523.97,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","NARS1","ENSG00000134440","Aminoacyl-tRNA biosynthesis","Cytosolic tRNA aminoacylation","Photodynamic therapy-induced unfolded protein response",20489.5,20478.7,20391.6,21624.7,21700,21522.9,0.9462154343414406,-0.0797594010994522,4.1671199720191111E-5,4.380163995958406,0.01692082215304871,1.7715785391777388,18]
["O43791","Speckle-type POZ protein [OS=Homo sapiens]",3,1,1,1,374,42.1,5.8,3.23,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","SPOP","ENSG00000121067","Hedgehog signaling pathway","Hedgehog 'on' state","mRNA processing; Hedgehog signaling pathway",55.6,55.9,51,101,83.8,49.2,0.6944444444444444,-0.5260688116675878,0.19462691983488664,0.710797090443938,0.4527460716337322,0.34414530926391956,3142]
["O43795","Unconventional myosin-Ib [OS=Homo sapiens]",7,7,9,7,1136,131.9,9.38,22.07,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","MYO1B","ENSG00000128641","Pathogenic Escherichia coli infection","","",631,662.5,621.5,595,555.3,855.9,0.9545409231382715,-0.06712104462006771,0.7652067821931199,0.11622118938181185,0.849596896711152,0.07078708258991766,6583]
["O43808","peroxisomal membrane protein PMP34 [OS=Homo sapiens]",8,3,6,3,307,34.5,10.08,14.39,"other metabolic processes;transport","other membranes;cytosol;other cytoplasmic organelle","transporter activity;other molecular function","SLC25A17","ENSG00000100372","Peroxisome","Class I peroxisomal membrane protein import; Alpha-oxidation of phytanate","",834.5,734,816,790.2,800.9,428.8,1.1805039853458092,0.2394029120696728,0.38982721574577167,0.4091278439366986,0.6009801982463289,0.2211398373716823,4741]
["O43809","Cleavage and polyadenylation specificity factor subunit 5 [OS=Homo sapiens]",60,13,65,13,227,26.2,8.82,198.22,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","NUDT21","ENSG00000167005","mRNA surveillance pathway","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs","mRNA processing",9021.5,9214.3,9290.6,8855,9240.8,9662.8,0.9916350248211365,-0.012118866178154717,0.7693350970884063,0.11388445458403935,0.8522385911820493,0.06943880390939153,6598]
["O43813","LanC-like protein 1 [OS=Homo sapiens]",23,8,19,8,399,45.3,7.75,56.37,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","LANCL1","ENSG00000115365","Glutathione metabolism; Metabolic pathways","","",1751,1712.8,1766.9,1518.3,1540.6,1446.6,1.1609588280989902,0.21531680979982423,0.001762212213334275,2.7539417931257315,0.055757615009784475,1.253695811133903,231]
["O43815","striatin [OS=Homo sapiens]",31,19,52,19,780,86.1,5.27,148.03,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","STRN","ENSG00000115808","","Extra-nuclear estrogen signaling; PIP3 activates AKT signaling; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins","",5344,5366.3,5096,5585.3,5696.3,6241.7,0.9020161727528491,-0.14877479428790097,0.06037697446307846,1.219128653600291,0.26440701399079714,0.5777270283955648,1669]
["O43818","U3 small nucleolar RNA-interacting protein 2 [OS=Homo sapiens]",34,14,42,14,475,51.8,7.85,119.52,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","RRP9","ENSG00000114767","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",4563.8,6084.7,5717.2,5294.4,4605.5,7108.3,0.9622241036676427,-0.05555515557300077,0.8188514996337413,0.08679485127649351,0.8865331966853822,0.05230499738134078,6751]
["O43819","Protein SCO2 homolog, mitochondrial [OS=Homo sapiens]",41,9,41,9,266,29.8,8.85,136.52,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","other membranes;cytoskeleton;mitochondrion","other molecular function","SCO2","ENSG00000284194","Central carbon metabolism in cancer","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","",2995.6,2943.7,2886.9,2897.6,2781.2,3879.4,0.9234165428637191,-0.1149465166113373,0.5237738058554061,0.2808562246143168,0.6838625843153204,0.16503115686048736,5598]
["O43823","A-kinase anchor protein 8 [OS=Homo sapiens]",30,12,37,12,692,76.1,5.15,125.45,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","mitochondrion;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","AKAP8","ENSG00000105127","","","G protein signaling pathways",3206.7,3021.5,3140.4,3875.2,4080.6,2723.5,0.8772672366166323,-0.18891170579421582,0.3628316094926159,0.44029488470393574,0.5882733437847226,0.23042083019403173,4508]
["O43824","Putative GTP-binding protein 6 [OS=Homo sapiens]",11,5,7,5,516,56.8,9.42,21.19,"","","","","","","","",636.7,712.4,603.2,715.5,642.9,1442.4,0.6970508426163953,-0.5206642053425882,0.33337498113818154,0.47706699587374773,0.5734614584935206,0.24149576507928913,4249]
["O43826-1","Glucose-6-phosphate exchanger SLC37A4 [OS=Homo sapiens]",9,3,9,3,429,46.3,8.62,22.03,"other metabolic processes;transport;other biological processes","other membranes;ER/Golgi","transporter activity","SLC37A4","ENSG00000281500","Carbohydrate digestion and absorption","Gluconeogenesis; Glycogen storage disease type Ib (SLC37A4)","",818.9,868,822.5,777.8,803.8,690.5,1.1044408256678844,0.1433161232631612,0.10408708159615908,0.982603168084524,0.343929692308466,0.46353032883321166,2212]
["O43829","Zinc finger and BTB domain-containing protein 14 [OS=Homo sapiens]",20,5,6,5,449,50.9,6.04,14.2,"developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB14","ENSG00000198081","","","",360.8,314.7,325.5,407,461.2,656,0.65673796089752,-0.6066102462930426,0.0858564445393638,1.0662271003535138,0.31549761344304167,0.5010039215939764,1989]
["O43837-1","isocitrate dehydrogenase [NAD] subunit beta, mitochondrial [OS=Homo sapiens]",46,15,78,14,385,42.2,8.46,228.86,"other metabolic processes","mitochondrion","other molecular function","IDH3B","ENSG00000101365","Citrate cycle (TCA cycle); Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids","Citric acid cycle (TCA cycle)","TCA cycle (aka Krebs or citric acid cycle)",11823.6,12146.9,12147.5,10834.9,9659,8646,1.2394689068939837,0.30972208067635015,0.0222507108160936,1.652656110589739,0.16976038137247193,0.7701636577843105,958]
["O43847-1","Nardilysin [OS=Homo sapiens]",26,26,63,26,1150,131.5,5,183.22,"","","","","","","","",7242.7,8100.1,8254.6,7337.2,6665.7,5638.7,1.2013990713587488,0.264715453822496,0.08749368041069508,1.0580233145420213,0.31926675492849244,0.4958463019516246,2003]
["O43852","Calumenin [OS=Homo sapiens]",71,22,218,6,315,37.1,4.64,726.76,"","non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","CALU","ENSG00000128595","","Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","NOTCH1 regulation of endothelial cell calcification; VEGFA-VEGFR2 signaling pathway",24373.7,21947.5,21124.5,26480.9,23816.2,18907.5,0.9745840594411352,-0.03714146927207093,0.8206979047588722,0.08581667532882097,0.887611865327404,0.05177690088372555,6758]
["O43852-4","Isoform 4 of Calumenin [OS=Homo sapiens]",59,17,159,1,323,38.1,4.58,498.58,"","","","CALU","","","","",377.9,323.8,289.2,353.2,365.9,218.7,1.0566218809980807,0.0794591912858609,0.7582437464269356,0.1201911628220778,0.8448176132064744,0.07323704031376511,6560]
["O43861-1","Probable phospholipid-transporting ATPase IIB [OS=Homo sapiens]",9,8,12,8,1147,129.2,7.61,36.53,"cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ATP9B","ENSG00000166377","","Ion transport by P-type ATPases","",1428.9,1164.7,1271.3,1227,1412.9,1309.5,0.9786043449637921,-0.031202406594438847,0.7787094125224157,0.10862457580874403,0.8592371823862223,0.06588693770159477,6624]
["O43865","S-adenosylhomocysteine hydrolase-like protein 1 [OS=Homo sapiens]",29,14,43,7,530,58.9,6.89,134.9,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","nucleic acid binding activity;other molecular function","AHCYL1","ENSG00000168710","Cysteine and methionine metabolism; Metabolic pathways","Role of phospholipids in phagocytosis; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Ion homeostasis; Regulation of insulin secretion; VEGFR2 mediated cell proliferation; PLC beta mediated events; DAG and IP3 signaling; CLEC7A (Dectin-1) induces NFAT activation","Trans-sulfuration and one-carbon metabolism; One-carbon metabolism and related pathways",3588.2,3804.8,3806.4,3186.4,2955.9,2999.9,1.225022423486688,0.2928081573559797,2.4764271838090234E-3,2.6061744373705444,0.06306692085874618,1.2001983722205638,287]
["O43896","Kinesin-like protein KIF1C [OS=Homo sapiens]",9,10,10,4,1103,122.9,6.9,26.12,"transport;other biological processes","cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","KIF1C","ENSG00000129250","","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",282.7,290.3,266.8,279.9,332.3,632,0.674971869474361,-0.5671007180802222,0.2872464016709909,0.5417454030025,0.5379154367956117,0.26928599239977574,3903]
["O43903","Growth arrest-specific protein 2 [OS=Homo sapiens]",38,9,25,9,313,34.9,8.47,91.92,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton","cytoskeletal activity;other molecular function","GAS2","ENSG00000148935","","Caspase-mediated cleavage of cytoskeletal proteins","",2720.3,2725.7,2951.7,2971.8,3130.2,2280.9,1.0017654988130602,0.002544830595033756,0.9863810217172821,5.9552922950810265E-3,0.9924915869674581,3.2731659241367365E-3,7264]
["O43913","Origin recognition complex subunit 5 [OS=Homo sapiens]",19,9,17,9,435,50.3,7.74,48.42,"DNA metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ORC5","ENSG00000164815","Cell cycle","CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication","Cell cycle; G1 to S cell cycle control; DNA replication",2080.7,2028.2,2005,1984.5,2112.6,1643.4,1.0650465987283337,0.09091655372205953,0.4296345446724464,0.3669008065508946,0.6229317371574907,0.20555954210507216,5041]
["O43920","NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [OS=Homo sapiens]",11,1,2,1,106,12.5,9.14,3.58,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity","NDUFS5","ENSG00000168653","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",65.7,67.4,55.7,60.2,62.7,76.1,0.9487437185929649,-0.0759096660691698,0.6091989658354049,0.21524084258543405,0.7445878329918018,0.12808406468987193,5980]
["O43924","Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [OS=Homo sapiens]",25,3,5,3,150,17.4,5.67,16.56,"other biological processes","other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","PDE6D","ENSG00000156973","Purine metabolism; Metabolic pathways","ARL13B-mediated ciliary trafficking of INPP5E; RAS processing","Phosphodiesterases in neuronal function; Joubert syndrome; Ciliopathies",736.5,723.7,729,564.2,523.5,529.5,1.353697749196141,0.43690565293579314,1.3424388912884475E-4,3.8721054745522463,0.022299740582789232,1.651700189154461,44]
["O43929","origin recognition complex subunit 4 [OS=Homo sapiens]",15,5,11,5,436,50.3,8,26.58,"DNA metabolism;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","ORC4","ENSG00000115947","Cell cycle","CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication","Cell cycle; G1 to S cell cycle control; DNA replication",821.7,863.2,809.3,906,876.8,877.7,0.9374929524525465,-0.0931202497247915,0.04274283740318561,1.369136651389436,0.22621824661830817,0.6454723680840945,1381]
["O43933","Peroxisome biogenesis factor 1 [OS=Homo sapiens]",8,11,16,11,1283,142.8,6.33,44.12,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","PEX1","ENSG00000127980","Peroxisome","Peroxisomal protein import","",1333.5,1409.2,1327,1321.8,1363.9,1689.4,0.9301958812370001,-0.10439354304043669,0.44091109802077455,0.3556489695598805,0.629663777927675,0.20089128922707428,5118]
["O43934","UNC93-like protein MFSD11 [OS=Homo sapiens]",4,3,3,3,449,49.2,5.68,7.53,"","other membranes","","MFSD11","ENSG00000092931","","","",425.5,477,466.9,381,320.4,537,1.1057816537467702,0.1450665409477258,0.5467692886331625,0.26219588721271125,0.7000064338097364,0.1548979683354212,5709]
["O60216","Double-strand-break repair protein rad21 homolog [OS=Homo sapiens]",52,26,97,26,631,71.6,4.65,350.07,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","RAD21","ENSG00000164754","Cell cycle","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin","Cell cycle; Prion disease pathway; Regulation of sister chromatid separation at the metaphase-anaphase transition; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome",7044.5,7266.9,7246.3,8137,8262,7143.3,0.9157006749552933,-0.12705200893325064,0.14077878927607712,0.8514627741304965,0.3943856538209458,0.4040788913467443,2609]
["O60231","Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [OS=Homo sapiens]",23,21,45,21,1041,119.2,6.8,125.94,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","DHX16","ENSG00000204560; ENSG00000206486; ENSG00000226171; ENSG00000231377; ENSG00000233049; ENSG00000233418; ENSG00000233561","Spliceosome","mRNA Splicing - Major Pathway","mRNA processing",5620.4,5744.2,5747.9,6783.3,6634.3,6338.5,0.866188164668128,-0.20724763489385378,3.0261748762578514E-3,2.5191059786263392,0.06847774665810723,1.1644505390734692,323]
["O60232","Sjoegren syndrome/scleroderma autoantigen 1 [OS=Homo sapiens]",27,3,5,3,199,21.5,5.24,24.01,"cell cycle OR cell proliferation;other biological processes","","","ZNRD2","ENSG00000173465","","","",285.3,309.6,397,469.7,479.7,702.2,0.600569145071446,-0.7355977382005543,0.05725089193653568,1.2422177428728223,0.2600663574668361,0.5849158250878788,1609]
["O60234","glia maturation factor gamma [OS=Homo sapiens]",45,6,29,5,142,16.8,5.26,95.43,"protein metabolism;other metabolic processes;signal transduction;other biological processes","non-structural extracellular;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function","GMFG","ENSG00000130755","","Neutrophil degranulation","",2348.3,2115.8,2999.6,2702.7,2764.4,2701.4,0.9137173287629308,-0.13018017847276253,0.4259278874846311,0.37066392371073925,0.6215026810990555,0.2065569935162806,5009]
["O60237","Protein phosphatase 1 regulatory subunit 12b [OS=Homo sapiens]",13,11,12,10,982,110.3,5.67,29.37,"signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP1R12B","ENSG00000077157","Vascular smooth muscle contraction; Focal adhesion; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Proteoglycans in cancer","RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs","Focal adhesion",620.1,627.2,574.4,706.3,721.5,854.8,0.7980811355471832,-0.32539267187167104,0.03717012405560345,1.4298059894403483,0.211421351534946,0.6748511552236887,1285]
["O60244","Mediator of RNA polymerase II transcription subunit 14 [OS=Homo sapiens]",6,7,13,6,1454,160.5,8.73,34.12,"other biological processes","nucleus","other molecular function","MED14","ENSG00000180182","Thyroid hormone signaling pathway","Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","Vitamin D in inflammatory diseases",834.5,786.6,731,763.9,785.9,1622.8,0.7413793103448276,-0.43171624042547413,0.3904943510352889,0.4083852443268792,0.6015012037338096,0.2207634992062178,4745]
["O60256-1","Phosphoribosyl pyrophosphate synthase-associated protein 2 [OS=Homo sapiens]",34,10,27,9,369,40.9,7.44,112.72,"other metabolic processes;other biological processes","other cell component","enzyme regulator activity;other molecular function","PRPSAP2","ENSG00000141127","","","",2833.1,2969.1,2870.3,2837.7,2664.5,2649.7,1.063862412443725,0.0893115815531922,0.07548415565383551,1.122144198493208,0.3003340738562241,0.5223953929150432,1837]
["O60264","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 [OS=Homo sapiens]",39,40,133,40,1052,121.8,8.09,366.57,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMARCA5","ENSG00000153147","","Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; NoRC negatively regulates rRNA expression","",13851.9,13966,14005.5,15770,16147.3,21682.8,0.7802858576756386,-0.35792534283624367,0.10926385907642222,0.9615234647586661,0.3495008954002495,0.4565517072805621,2285]
["O60266","Adenylate cyclase type 3 [OS=Homo sapiens]",4,4,8,4,1144,128.9,6.58,20.91,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","ADCY3","ENSG00000138031","Purine metabolism; Metabolic pathways; Endocrine resistance; Rap1 signaling pathway; Calcium signaling pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Phospholipase D signaling pathway; Oocyte meiosis; Longevity regulating pathway; Longevity regulating pathway; Adrenergic signaling in cardiomyocytes; Vascular smooth muscle contraction; Apelin signaling pathway; Gap junction; Platelet activation; Circadian entrainment; Thermogenesis; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; GABAergic synapse; Olfactory transduction; Inflammatory mediator regulation of TRP channels; Insulin secretion; GnRH signaling pathway; Ovarian steroidogenesis; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Melanogenesis; Thyroid hormone synthesis; Oxytocin signaling pathway; Regulation of lipolysis in adipocytes; Aldosterone synthesis and secretion; Relaxin signaling pathway; Cortisol synthesis and secretion; Parathyroid hormone synthesis, secretion and action; Cushing syndrome; Growth hormone synthesis, secretion and action; Vasopressin-regulated water reabsorption; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Bile secretion; Morphine addiction; Vibrio cholerae infection; Human cytomegalovirus infection; Human T-cell leukemia virus 1 infection; Pathways in cancer; Chemical carcinogenesis; Dilated cardiomyopathy","FCGR3A-mediated IL10 synthesis; Olfactory Signaling Pathway; G alpha (i) signalling events; G alpha (z) signalling events; Adenylate cyclase inhibitory pathway; ADORA2B mediated anti-inflammatory cytokines production; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Adenylate cyclase activating pathway; Hedgehog 'off' state","Thyroid stimulating hormone (TSH) signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; Phosphodiesterases in neuronal function; Thermogenesis; Envelope proteins and their potential roles in EDMD physiopathology; Neuroinflammation and glutamatergic signaling; Calcium regulation in cardiac cells",274.3,232.2,273,265.4,307.7,350.7,0.843797358735657,-0.24503152326388988,0.16370783568178077,0.7859305330992503,0.42072453269976634,0.37600216327300606,2844]
["O60268-1","Uncharacterized protein KIAA0513 [OS=Homo sapiens]",9,3,3,3,411,46.6,5.06,9.16,"","other cell component","","KIAA0513","ENSG00000135709","","","",368.2,367.9,366.1,319.6,341.4,249,1.211208791208791,0.27644758185908447,0.08323056053543372,1.0797171805007049,0.31325034343639807,0.504108444188718,1942]
["O60271","C-jun-amino-terminal kinase-interacting protein 4 [OS=Homo sapiens]",33,37,102,2,1321,146.1,5.15,305,"transport;other biological processes","other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","SPAG9","ENSG00000008294","","Myogenesis","",10624,10514.3,10621.7,10545.3,10468.9,9689.2,1.0344131268849706,0.04881248843142071,0.27084869044419485,0.5672732598893494,0.5246840918252372,0.280102103206372,3773]
["O60271-2","Isoform 2 of C-Jun-amino-terminal kinase-interacting protein 4 [OS=Homo sapiens]",32,36,103,1,1311,145,5.19,309.2,"","","","SPAG9","","","","",376.8,367.3,364.5,387.6,387.5,124.8,1.2319146571841315,0.30090231453774735,0.47186143683560117,0.32618551418882724,0.6483991806413628,0.18815754262543455,5319]
["O60281-1","zinc finger protein 292 [OS=Homo sapiens]",2,5,5,5,2723,304.6,7.39,7.84,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF292","ENSG00000188994","","","",97,101,91.7,107.8,100.7,461,0.4327109783420463,-1.2085243709412696,0.3472229864610122,0.4593915318747775,0.580080641838523,0.23651162734913656,4375]
["O60285","NUAK family SNF1-like kinase 1 [OS=Homo sapiens]",2,1,1,1,661,74.3,8.82,2.03,"cell adhesion;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","NUAK1","ENSG00000074590","","Regulation of TP53 Activity through Phosphorylation","",67.2,59.5,60.4,82.8,80.8,156,0.5854192740926157,-0.7724578496871928,0.15026563887265787,0.8231403178433292,0.4046763281209493,0.3928921992830745,2714]
["O60287","nucleolar pre-ribosomal-associated protein 1 [OS=Homo sapiens]",8,14,26,14,2271,254.2,6.47,81.68,"RNA metabolism OR transcription;other metabolic processes","nucleus","","URB1","ENSG00000142207","","","",2778.1,2998.8,2980,3446.5,3317.7,10983.1,0.4934215345432827,-1.0191074139050993,0.3025997931874024,0.519131373132398,0.5523730990026783,0.25776748005570604,4004]
["O60291-1","E3 ubiquitin-protein ligase MGRN1 [OS=Homo sapiens]",6,2,2,2,552,60.7,5.15,7.27,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MGRN1","ENSG00000102858","Ubiquitin mediated proteolysis; Hedgehog signaling pathway","Antigen processing: Ubiquitination & Proteasome degradation","",145.9,184.8,183,130,115.8,163.8,1.2541503906250002,0.32671035834695944,0.14282545050477335,0.845194397399193,0.3963216468258878,0.4019522061409851,2634]
["O60292","Signal-induced proliferation-associated 1-like protein 3 [OS=Homo sapiens]",1,1,1,1,1781,194.5,8.32,2.87,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","enzyme regulator activity","SIPA1L3","ENSG00000105738","Rap1 signaling pathway","","",37.7,27,31.7,21.3,21.1,16.5,1.6366723259762306,0.7107655123995007,0.02272556289766473,1.643485350776092,0.17141500435400567,0.7659511659428845,969]
["O60293","Zinc finger C3H1 domain-containing protein [OS=Homo sapiens]",8,11,13,11,1989,226.2,8.13,35.99,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","other molecular function","ZFC3H1","ENSG00000133858","","","",597.9,589.1,598.5,830.6,884.6,868.4,0.6910899520049544,-0.5330545914149619,8.2177581364612792E-5,4.0852466449609794,0.02002119807313183,1.6985099377966688,30]
["O60294","tRNA wybutosine-synthesizing protein 4 [OS=Homo sapiens]",5,3,3,3,686,75.6,6.73,3.98,"RNA metabolism OR transcription;other metabolic processes","other cell component","other molecular function","LCMT2","ENSG00000168806","","Synthesis of wybutosine at G37 of tRNA(Phe)","",351,364.9,345.3,354.7,347.9,191.8,1.1864937388193206,0.2467044873855062,0.35754104992794605,0.4466740888734405,0.5873831274271427,0.23107853273751197,4449]
["O60306","Intron-binding protein aquarius [OS=Homo sapiens]",14,20,39,19,1485,171.2,6.37,107.07,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","AQR","ENSG00000021776","Spliceosome","mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER","",3760.1,3858.4,3988.9,4478,4610.9,4476.3,0.8556748149677115,-0.2248654664468546,1.2215805727261598E-3,2.913077882651796,0.0474921936492314,1.323377770031503,188]
["O60307","Microtubule-associated serine/threonine-protein kinase 3 [OS=Homo sapiens]",3,4,6,2,1309,143,8.06,12.05,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction","","kinase activity;other molecular function","MAST3","ENSG00000099308","","","",156.4,139.2,143.1,205.7,198.1,274.2,0.6470501474926255,-0.6280505670044754,0.03220541267475281,1.4920711314958142,0.19965170588614783,0.6997269747069305,1179]
["O60308","Centrosomal protein of 104 kDa [OS=Homo sapiens]",2,2,3,2,925,104.4,7.62,7.45,"","cytoskeleton;other cell component","other molecular function","CEP104","ENSG00000116198","","","Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies",308.4,353.2,360,293,235.7,337.8,1.178995960761685,0.23755877565519176,0.19967845981123084,0.6996687818477464,0.45836993177144664,0.3387838790294049,3184]
["O60313-2","Isoform 2 of Dynamin-like 120 kDa protein, mitochondrial [OS=Homo sapiens]",41,39,101,39,997,115.8,7.87,303.65,"","","","OPA1","","","","",12725.5,13066.9,12829.4,12934.5,12496.6,10329.4,{"$f":"AVERAGE(S450:U450)/AVERAGE(V450:X450)","v":1.080012863354819},{"$f":"LOG(Y450,2)","v":0.11104849552549415},{"$f":"TTEST(V450:X450,S450:U450,2,2)","v":0.3051453838824205},0.5154931954912848,{"$f":"AA450*7309/AE450","v":0.5546649119116169},0.25596930671022294,4021]
["O60318","Germinal-center associated nuclear protein [OS=Homo sapiens]",12,13,21,13,1980,218.3,6.39,81.22,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","MCM3AP","ENSG00000160294","","","",1251.3,1334.6,1209.9,1281.1,1266.5,1720,0.8894460586746648,-0.16902098039242489,0.36278083844786796,{"$f":"-LOG10(AA451)","v":0.44035565980412333},0.5883215327746765,{"$f":"-LOG10(AC451)","v":0.2303852559911279},4507]
["O60331","Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [OS=Homo sapiens]",9,6,10,5,668,73.2,5.29,22.5,"cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","PIP5K1C","ENSG00000186111","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Phospholipase D signaling pathway; Endocytosis; Focal adhesion; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Yersinia infection; Choline metabolism in cancer","Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion","B cell receptor signaling pathway; Focal adhesion; Regulation of actin cytoskeleton",985.6,1038.8,1003.5,882.3,877.3,1325.8,0.9813638426135998,-0.027139977183083218,0.904169471466479,0.04375016064774896,0.9377855352559238,0.027896470261044266,7047]
["O60333","Kinesin-like protein KIF1B [OS=Homo sapiens]",15,21,28,9,1816,204.3,5.6,85.55,"cell-cell signaling;transport;other biological processes","other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","KIF1B","ENSG00000054523","","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","Intracellular trafficking proteins involved in CMT neuropathy",2133.9,2246.8,2215.1,2461.7,2460.7,3108.3,0.8213231723261983,-0.283978092892825,0.09358997925066206,1.0287706490088744,0.32839613938698464,0.4836019570726473,2083]
["O60333-3","Isoform 3 of Kinesin-like protein KIF1B [OS=Homo sapiens]",13,13,18,1,1153,130.3,8.43,47.74,"","","","KIF1B","","","","",34,37.1,35.2,47,43.7,28.9,0.8887959866220735,-0.1700757926670005,0.4756546334503664,0.3227082683440665,0.6503104593880898,0.18687926088061194,5346]
["O60337","E3 ubiquitin-protein ligase MARCH6 [OS=Homo sapiens]",2,2,2,2,910,102.5,6.28,5.33,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","other molecular function","MARCHF6","ENSG00000145495","Protein processing in endoplasmic reticulum","ER Quality Control Compartment (ERQC)","",219.1,242.7,217.4,282.2,288.9,535.9,0.613550135501355,-0.7047468581158762,0.16430974299106355,0.7843366836629162,0.4207918400566515,0.37593269055757145,2854]
["O60341","Lysine-specific histone demethylase 1A [OS=Homo sapiens]",20,13,20,13,852,92.8,6.52,66.77,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KDM1A","ENSG00000004487","Thermogenesis","Estrogen-dependent gene expression; Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; Factors involved in megakaryocyte development and platelet production; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3","Androgen receptor signaling pathway; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; Thermogenesis; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects",1866,1946.2,1851.2,2261.8,2179,2059,0.8713191175113081,-0.19872689738036126,0.01333101362203531,1.8751368278014018,0.13551652095056477,0.8680077563003115,719]
["O60343-1","TBC1 domain family member 4 [OS=Homo sapiens]",1,1,1,1,1298,146.5,7.01,0,"transport;other biological processes","cytosol;other cell component","enzyme regulator activity","TBC1D4","ENSG00000136111","Thyroid hormone signaling pathway; Insulin resistance; Diabetic cardiomyopathy","Translocation of SLC2A4 (GLUT4) to the plasma membrane","Ciliary landscape; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling",41.3,30,27.5,23.3,23.9,18.5,1.5038051750380514,0.5886176712623478,0.07347091314927219,1.1338845623983675,0.2963570111523347,0.5281847938551888,1812]
["O60344-1","Endothelin-converting enzyme 2 [OS=Homo sapiens]",5,4,10,4,883,99.7,5.1,26.93,"protein metabolism;other metabolic processes;developmental processes","plasma membrane;other membranes;ER/Golgi","other molecular function","EEF1AKMT4-ECE2","ENSG00000284917","","","",1191.9,1190.2,1124.9,1393.1,1286.6,2842.5,0.635072978160878,-0.6550057090163577,0.2521082767182136,0.5984128961956544,0.5104319652447157,0.2920621362173393,3610]
["O60353-1","Frizzled-6 [OS=Homo sapiens]",6,3,3,3,706,79.2,7.96,6.58,"cell-cell signaling;cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","FZD6","ENSG00000164930","mTOR signaling pathway; Wnt signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Proteoglycans in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer","Class B/2 (Secretin family receptors); Ca2+ pathway; PCP/CE pathway; Regulation of FZD by ubiquitination; Signaling by RNF43 mutants","Alzheimer's disease and miRNA effects; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Osteoblast differentiation and related diseases; Malignant pleural mesothelioma; Alzheimer's disease",104.2,107.9,109.8,115.1,126.5,246.4,0.6596311475409837,-0.6002685709725702,0.25810499270191173,0.5882035945188261,0.5159981924667049,0.2873518196966469,3656]
["O60361","putative nucleoside diphosphate kinase [OS=Homo sapiens]",66,8,139,1,137,15.5,8.57,432.69,"other metabolic processes;other biological processes","","kinase activity;other molecular function","NME2P1","","","Interconversion of nucleotide di- and triphosphates","",881.8,925.5,904.1,692.4,652.8,165.6,1.7946783161239084,0.8437252739519874,0.07799221724867142,1.1079487328812352,0.3046740330681664,0.5161645584972723,1871]
["O60381-1","HMG box-containing protein 1 [OS=Homo sapiens]",5,2,2,2,514,57.6,6.19,7.78,"cell-cell signaling;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HBP1","ENSG00000105856; ENSG00000283847; ENSPPAG00000042116; ENSPTRG00000019575","","","",214.4,230,232.9,154.4,152.8,222,1.279856386999244,0.3559819341409236,0.10374918109608623,0.9840153225373591,0.34374558686822043,0.46376286875755796,2206]
["O60427","Fatty acid desaturase 1 [OS=Homo sapiens]",2,1,1,1,444,51.9,8.87,2.12,"cell-cell signaling;other metabolic processes;stress response;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","FADS1","ENSG00000149485","Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism","PPARA activates gene expression; alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Linoleic acid metabolism affected by coronavirus infection",252.9,220.1,231.9,367,389,419.4,0.5997107367704612,-0.7376612929243543,9.4871252888430473E-4,3.0228653640030756,0.04152179565039152,1.381723873266686,167]
["O60447","Ecotropic viral integration site 5 protein homolog [OS=Homo sapiens]",3,2,2,2,810,92.9,6.1,6.74,"cell cycle OR cell proliferation;transport;other biological processes","cytosol;cytoskeleton;nucleus","enzyme regulator activity;other molecular function","EVI5","ENSG00000067208","","","",90.2,87.6,86.1,96.1,89.2,93.6,0.9462172821799928,-0.07975658370204378,0.10003038925516641,0.999868041191355,0.3378567999380829,0.47126733574191376,2164]
["O60449","Lymphocyte antigen 75 [OS=Homo sapiens]",7,11,15,11,1722,198.2,6.67,42.58,"stress response;transport;other biological processes","plasma membrane;other membranes","other molecular function","LY75","ENSG00000054219","","","",1550.4,1628.7,1418.3,1687.8,1741.2,1922.4,0.859102290989274,-0.21909817549458516,0.0553566259827684,1.2568303882355574,0.25607694892914823,0.5916295133060071,1580]
["O60476","mannosyl-oligosaccharide 1,2-alpha-mannosidase IB [OS=Homo sapiens]",7,4,10,4,641,73,7.61,26.26,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","MAN1A2","ENSG00000198162","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum","Intra-Golgi traffic; Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2","",775.1,822.2,792.9,758.6,743.5,1118.5,0.91208120277799,-0.13276582134167014,0.5672049412148774,0.24625999444521568,0.7136686030882319,0.14650340903747144,5809]
["O60486","Plexin-C1 [OS=Homo sapiens]",24,30,84,29,1568,175.6,7.61,247.2,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","PLXNC1","ENSG00000136040","Axon guidance","Other semaphorin interactions","",8747.8,8446.7,8672.5,7173.7,7596.6,6837.2,1.1971306259400671,0.2595805817834575,0.003940018462520272,2.4045017431104942,0.0778313376825964,1.1088455052935164,370]
["O60488-1","Long-chain-fatty-acid--CoA ligase 4 [OS=Homo sapiens]",42,23,70,20,711,79.1,8.38,174.26,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ACSL4","ENSG00000068366","Fatty acid biosynthesis; Fatty acid degradation; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; Peroxisome; Ferroptosis; Thermogenesis; Adipocytokine signaling pathway","Synthesis of very long-chain fatty acyl-CoAs; Intracellular metabolism of fatty acids regulates insulin secretion","Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters",8744.9,8634.1,9401,8245.1,8046.9,7127.4,1.1434964175000213,0.19345184588684003,0.05572003994437843,1.2539885809125229,0.25678295835653336,0.590433802010135,1586]
["O60493-1","sorting nexin-3 [OS=Homo sapiens]",15,2,3,2,162,18.8,8.66,9.39,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","LOC111158258; Snx3; SNX3; Snx3_1","ENSAMEG00000008145; ENSANAG00000028701; ENSBIXG00000016466; ENSBIXG00005007963; ENSBMUG00000010256; ENSBTAG00000018801; ENSCANG00000036155; ENSCATG00000029122; ENSCCAG00000022069; ENSCGRG00015001325; ENSCHIG00000003391; ENSCJAG00000005955; ENSCSAG00000015156; ENSDLEG00000017815; ENSFCAG00000024997; ENSG00000112335; ENSLCNG00005012116; ENSMFAG00000039300; ENSMMNG00015010894; ENSMMUG00000020366; ENSMNEG00000027766; ENSMPUG00000009812; ENSMUSG00000019804; ENSNVIG00000004406; ENSOARG00000010805; ENSPANG00000017995; ENSPCOG00000020531; ENSPCTG00005013214; ENSPPAG00000032382; ENSPPYG00000016894; ENSPTRG00000018473; ENSPTRG00000046352; ENSRFEG00010011106; ENSRROG00000037899; ENSSBOG00000028606; ENSSSCG00000004385; ENSSSCG00070023370; ENSSSUG00005019212; ENSSTOG00000007274; ENSTSYG00000035289; ENSTTRG00000008868; ENSUAMG00000027552","Endocytosis","Ub-specific processing proteases; WNT ligand biogenesis and trafficking; Ub-specific processing proteases; WNT ligand biogenesis and trafficking; WNT ligand biogenesis and trafficking; Ub-specific processing proteases; WNT ligand biogenesis and trafficking","",294.8,264.3,452.6,470.7,471.2,662.4,0.6306177148912299,-0.6651623970723373,0.08438070419367484,1.073756854562682,0.3148231582192799,0.5019333286734454,1959]
["O60496","Docking protein 2 [OS=Homo sapiens]",43,11,20,11,412,45.4,6.02,62.11,"signal transduction","cytosol","signal transduction activity or receptor binding","DOK2","ENSG00000147443","","RET signaling; Tie2 Signaling","RAC1/PAK1/p38/MMP2 pathway; IL-4 signaling pathway; EGF/EGFR signaling pathway",1635.2,1742.4,1671.9,1788.8,1798.2,2269.3,0.8622338336492325,-0.2138489205868261,0.1716379886225618,0.7653865834847441,0.4287430139584088,0.3678029433900632,2926]
["O60499","Syntaxin-10 [OS=Homo sapiens]",19,2,3,2,249,28.1,4.89,9.32,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","STX10","ENSG00000104915","Salmonella infection","Retrograde transport at the Trans-Golgi-Network","",21.2,24.1,25,21.3,24.2,23.3,1.0218023255813953,0.031116124370437235,0.7444707423349999,0.1281523653290528,0.8360996705172886,0.07774194770990099,6508]
["O60502","protein O-GlcNAcase [OS=Homo sapiens]",33,27,59,27,916,102.8,4.91,160.99,"protein metabolism;other metabolic processes","cytosol;nucleus","other molecular function","OGA","ENSG00000198408","Insulin resistance","","",6743.4,6853.8,6550.9,8554.2,8713.5,6651.8,0.8423294801312735,-0.2475434359733529,0.1330566235829883,0.8759635013159551,0.3840880180758537,0.4155692407772997,2532]
["O60506","Heterogeneous nuclear ribonucleoprotein Q [OS=Homo sapiens]",58,32,270,2,623,69.6,8.59,831.37,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","ER/Golgi;nucleus;other cell component","nucleic acid binding activity","SYNCRIP","ENSG00000135316","","","",15339.5,15816.5,15020.6,18221.6,17923,15128.9,0.9005938740284941,-0.1510514305973122,0.16838917149135751,0.7736858398717397,0.4255727712414703,0.3710261666102599,2892]
["O60506-3","Isoform 3 of Heterogeneous nuclear ribonucleoprotein Q [OS=Homo sapiens]",56,29,255,1,562,62.6,7.56,769.42,"","","","SYNCRIP","","","","",449,412.4,450.3,565.7,581.9,1295,0.5370097437157129,-0.8969798296137169,0.19247686472471445,0.7156214642137358,0.45162549093834287,0.34522155332495125,3115]
["O60508","pre-mRNA-processing factor 17 [OS=Homo sapiens]",21,10,17,10,579,65.5,7.06,44.75,"RNA metabolism OR transcription;other metabolic processes","nucleus","","CDC40","ENSG00000168438","Spliceosome","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway","mRNA processing",1550.5,1557.4,1526.3,1884.7,2035.2,1401.4,0.8708774171724954,-0.19945843241596853,0.29756659071497077,0.5264158307962773,0.5475614832667979,0.26156710873564787,3972]
["O60512","beta-1,4-galactosyltransferase 3 [OS=Homo sapiens]",22,6,13,6,393,43.9,9.25,41.19,"protein metabolism;other metabolic processes","other membranes;cytosol;ER/Golgi","other molecular function","B4GALT3","ENSG00000158850","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Other types of O-glycan biosynthesis; Mannose type O-glycan biosynthesis; Glycosaminoglycan biosynthesis; Glycosphingolipid biosynthesis; Metabolic pathways","N-Glycan antennae elongation; Keratan sulfate biosynthesis","",534.4,446.8,488.7,592,681.3,877.6,0.6833883490631829,-0.5492224430991853,0.061477585452694855,1.211283197860047,0.26667042853041345,0.5740251411834314,1685]
["O60518","ran-binding protein 6 [OS=Homo sapiens]",7,6,30,3,1105,124.6,5.01,74.1,"transport","nucleus;other cell component","other molecular function","RANBP6","ENSG00000137040","","","",187.8,200.8,199.4,196.5,195.8,258,0.9041980624327234,-0.14528926871653022,0.37921361733465325,0.42111607579833327,0.5954183306335082,0.2251777992317217,4655]
["O60524","nuclear export mediator factor NEMF [OS=Homo sapiens]",16,16,29,16,1076,122.9,6.35,83.71,"protein metabolism;other metabolic processes;transport","nucleus;other cell component","translation activity;nucleic acid binding activity","NEMF","ENSG00000165525","","","",3334.4,3539.2,3644.5,3779.2,3725.1,3271.4,0.9760943604591814,-0.03490747293301238,0.6666241947631065,0.17611892790708034,0.7857371777977014,0.10472269737005802,6201]
["O60547-1","GDP-mannose 4,6 dehydratase [OS=Homo sapiens]",32,11,32,11,372,41.9,7.31,83.54,"other metabolic processes;signal transduction","cytosol;other cell component","other molecular function","GMDS","ENSG00000112699; ENSPPAG00000026874; ENSPPYG00000016168; ENSPTRG00000017663","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars","GDP-fucose biosynthesis","",3969.2,4105,4171.2,3581.9,3324.7,3696.9,1.1548450983165934,0.20769935304614662,0.011910564477101152,1.9240676555213432,0.12820959611654245,0.892079467917872,679]
["O60551","Glycylpeptide N-tetradecanoyltransferase 2 [OS=Homo sapiens]",20,8,34,4,498,56.9,7.58,109.02,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","NMT2","ENSG00000152465","","Membrane binding and targetting of GAG proteins; Inactivation, recovery and regulation of the phototransduction cascade","",480.5,497.3,456.3,414.8,367.4,2429.6,0.446509745314154,-1.1632364316058754,0.43254308487154314,0.3639706267193461,0.6243004358858825,0.20460636184467185,5064]
["O60563","Cyclin-T1 [OS=Homo sapiens]",18,11,17,11,726,80.6,8.78,48.91,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","CCNT1","ENSG00000129315","Transcriptional misregulation in cancer","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interactions of Tat with host cellular proteins","Initiation of transcription and translation elongation at the HIV-1 LTR; Male infertility",1918.4,1866.2,1817.4,1881.5,1950,1825.1,0.9903475586041083,-0.013993172646238531,0.7149765055378597,0.14570822908410413,0.8149973922296033,0.08884378088223843,6412]
["O60566","Mitotic checkpoint serine/threonine-protein kinase BUB1 beta [OS=Homo sapiens]",20,18,29,18,1050,119.5,5.27,70.87,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","BUB1B","ENSG00000156970","Cell cycle; Human T-cell leukemia virus 1 infection","Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A","Regulation of sister chromatid separation at the metaphase-anaphase transition",2986.3,3100,3068.6,3456.6,3177.8,3709.4,0.8850615827838899,-0.17615025315396823,0.06530932427423233,1.1850248096627671,0.27608204229055183,0.5589618410527166,1729]
["O60568","Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 [OS=Homo sapiens]",28,18,49,18,738,84.7,6.05,140.33,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;other membranes;ER/Golgi","other molecular function","PLOD3","ENSG00000106397","Lysine degradation; Other types of O-glycan biosynthesis; Metabolic pathways","Collagen biosynthesis and modifying enzymes","VEGFA-VEGFR2 signaling pathway; IL-18 signaling pathway",5436.6,5708.1,5607.6,5670.6,5357.1,7017.2,0.9283675720009533,-0.10723196484874303,0.4501554405649234,0.34663749661788623,0.6352937082620245,0.19702544575180733,5179]
["O60573","eukaryotic translation initiation factor 4E type 2 [OS=Homo sapiens]",27,6,12,6,245,28.3,8.88,35.32,"protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF4E2","ENSG00000135930","EGFR tyrosine kinase inhibitor resistance; HIF-1 signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Longevity regulating pathway; Insulin signaling pathway","ISG15 antiviral mechanism","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; EGFR tyrosine kinase inhibitor resistance",1380,1481,1597,2053.8,2003.7,1392.3,0.8180116701530331,-0.2898066693831646,0.2101588737873063,0.6774522675405474,0.4694533033347866,0.32840760065585994,3272]
["O60583-2","Isoform 2 of Cyclin-T2 [OS=Homo sapiens]",4,2,2,2,663,73.6,9.14,4.4,"","","","CCNT2","","","","",33.1,41.4,31.1,36.3,33,33.6,1.0262390670553934,0.03736685246448462,0.7993067335597719,0.09728652840941138,0.8726113391468816,0.05917914787346622,6695]
["O60610-1","Protein diaphanous homolog 1 [OS=Homo sapiens]",51,64,287,62,1272,141.3,5.41,788.76,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","DIAPH1","ENSG00000131504","Focal adhesion; Regulation of actin cytoskeleton; AGE-RAGE signaling pathway in diabetic complications; Shigellosis","RHOA GTPase cycle; RHOC GTPase cycle; RHO GTPases Activate Formins; RHOB GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; ERBB2 Regulates Cell Motility","Microtubule cytoskeleton regulation; AGE/RAGE pathway; Focal adhesion; Type 2 papillary renal cell carcinoma; Regulation of actin cytoskeleton; G13 signaling pathway",31822.5,32313.9,31874.3,30399,29739.8,31001.7,1.0534361782083705,0.07510291199917381,0.014902453782192807,1.8267422163979818,0.14219586774679793,0.8471130241466128,766]
["O60613-1","selenoprotein F [OS=Homo sapiens]",30,4,18,4,162,17.8,5.03,52.18,"","","","","","","","",1675.5,1631,1892.6,1766.6,1898.4,2401,0.8570886910649523,-0.2224835935378759,0.23988616397708906,0.6199948003093166,0.49895502917146956,0.3019385955846199,3514]
["O60637","Tetraspanin-3 [OS=Homo sapiens]",6,2,4,2,253,28,5.81,9.72,"","plasma membrane;other membranes","","TSPAN3","ENSG00000140391","","","",734.8,776.9,715.4,749.3,750.9,1351.9,0.7808632235896358,-0.3568582276082685,0.35941724937176855,0.44440108380131094,0.5879544932090995,0.23065628636090935,4468]
["O60645","exocyst complex component 3 [OS=Homo sapiens]",18,12,32,12,756,86.8,6.11,85.84,"","","","","","","","",3138.5,3388.4,3246.2,3159.2,2964.1,2478.7,1.1361427574982559,0.18414412233817584,0.1434133806623953,0.8434103265152195,0.3970486360838816,0.40115629150107757,2640]
["O60664-1","Perilipin-3 [OS=Homo sapiens]",58,23,80,23,434,47,5.44,261.45,"transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","PLIN3","ENSG00000105355","","RHOBTB3 ATPase cycle; Late endosomal microautophagy; Triglyceride catabolism; Retrograde transport at the Trans-Golgi-Network; Lipophagy; Chaperone Mediated Autophagy","",11319.5,10902.7,10366.2,10852.4,10944.6,10650.6,1.0043393039855029,6.2467488504550535E-3,0.8789694814609748,0.05602620372393821,0.9226465517734115,0.03496463701554541,6963]
["O60669","monocarboxylate transporter 2 [OS=Homo sapiens]",5,3,6,3,478,52.2,9.31,15.05,"transport","plasma membrane;other membranes;nucleus","transporter activity","SLC16A7","ENSG00000118596","","Proton-coupled monocarboxylate transport","Male infertility",865.7,836.9,826,772.5,884.6,792.5,1.032250163291966,0.0457926467344737,0.5104829749683351,0.29201873741762124,0.6756827352487433,0.17025717783689268,5522]
["O60671-1","Cell cycle checkpoint protein RAD1 [OS=Homo sapiens]",20,4,10,4,282,31.8,4.83,32.83,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RAD1","ENSCCAG00000029737; ENSG00000113456; ENSGGOG00000004219; ENSMFAG00000012657; ENSMMUG00000045918; ENSPANG00000024799; ENSPPAG00000028406; ENSPPYG00000015389; ENSPTRG00000016783","Cellular senescence","Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA)","miRNA regulation of DNA damage response; ATR signaling; DNA damage response",894.5,1089.9,1171.7,959.4,843,813.7,1.2064141279003098,0.27072522872283716,0.12651074009933988,0.8978726035958101,0.3754230610580898,0.4254790535509403,2463]
["O60674","Tyrosine-protein kinase JAK2 [OS=Homo sapiens]",2,2,2,2,1132,130.6,7.21,5.57,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","JAK2","ENSG00000096968","EGFR tyrosine kinase inhibitor resistance; Chemokine signaling pathway; PI3K-Akt signaling pathway; Necroptosis; Signaling pathways regulating pluripotency of stem cells; JAK-STAT signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; Cholinergic synapse; Prolactin signaling pathway; Adipocytokine signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Leishmaniasis; Toxoplasmosis; Tuberculosis; Hepatitis B; Influenza A; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Pathways in cancer; Chemical carcinogenesis; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis","RMTs methylate histone arginines; Potential therapeutics for SARS; Signaling by BRAF and RAF1 fusions; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Signaling by SCF-KIT; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Interleukin-4 and Interleukin-13 signaling; Cyclin D associated events in G1; Factors involved in megakaryocyte development and platelet production; Growth hormone receptor signaling; Interleukin-6 signaling; Signaling by Leptin; Regulation of IFNG signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; RAF activation; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; Prolactin receptor signaling; IL-6-type cytokine receptor ligand interactions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-12 signaling; Interleukin-23 signaling; Interleukin-27 signaling; Erythropoietin activates Phospholipase C gamma (PLCG); Erythropoietin activates STAT5; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants","IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Mesodermal commitment pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Mesodermal commitment pathway; IL-6 signaling pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; PI3K-Akt signaling pathway; Immune response to tuberculosis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; EGF/EGFR signaling pathway; Overview of interferons-mediated signaling pathway; Gastrin signaling pathway; Hepatitis B infection; EGFR tyrosine kinase inhibitor resistance; mBDNF and proBDNF regulation of GABA neurotransmission; 16p11.2 distal deletion syndrome; CCL18 signaling pathway; EPO receptor signaling; Notch signaling pathway (Netpath); Type II interferon signaling (IFNG); Serotonin receptor 2 and STAT3 signaling",36.7,47.4,43.6,39.7,33.7,33.3,1.1968134957825678,0.2591983488782987,0.13566087665344878,0.8675453808098055,0.387928539694858,0.41124826841219503,2556]
["O60678","protein arginine N-methyltransferase 3 [OS=Homo sapiens]",7,3,4,3,531,59.8,5.35,11.5,"","","","","","","","",177.6,192.2,183.8,186.8,189.4,173.7,1.0067284960901979,0.00967465637568225,0.8575000357956388,0.06676585315592298,0.9093830182284278,0.04125316004794088,6892]
["O60683-1","Peroxisome biogenesis factor 10 [OS=Homo sapiens]",11,2,2,2,326,37,9.99,7.37,"cell organization and biogenesis;transport","other membranes;other cytoplasmic organelle","other molecular function","PEX10","ENSG00000157911","Peroxisome","E3 ubiquitin ligases ubiquitinate target proteins; Peroxisomal protein import","Male infertility",238,273.6,241.2,233.5,222.1,712.8,0.6442998972954467,-0.6341957301006422,0.4409268240621383,0.355633479790579,0.6295632266204666,0.20096064745685155,5119]
["O60684","Importin subunit alpha-7 [OS=Homo sapiens]",40,20,64,15,536,60,4.98,212.03,"transport;other biological processes","nucleus;other cell component","other molecular function","KPNA6","ENSG00000025800","Nucleocytoplasmic transport; Influenza A; Chemical carcinogenesis","Assembly of the ORC complex at the origin of replication","",7198.7,7004.2,6894.4,7048.3,7090.5,5137.5,1.0944683367658732,0.1302302176055477,0.4033797971277537,0.39428585678178063,0.6097834409941575,0.21482437331682816,4835]
["O60701","UDP-glucose 6-dehydrogenase [OS=Homo sapiens]",27,10,21,10,494,55,7.12,73.03,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes","cytosol;nucleus","other molecular function","UGDH","ENSG00000109814","Pentose and glucuronate interconversions; Ascorbate and aldarate metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars","Formation of the active cofactor, UDP-glucuronate","Glucuronidation",1979.9,2147.9,1915.6,2047.8,1980.8,2457.5,0.9317463498866807,-0.10199083267533453,0.419882547396242,0.3768721766290974,0.6178621982925574,0.20910837474034777,4967]
["O60704","Protein-tyrosine sulfotransferase 2 [OS=Homo sapiens]",7,2,2,2,377,41.9,9.09,6.91,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","TPST2","ENSG00000128294","","Cytosolic sulfonation of small molecules; Gamma carboxylation, hypusine formation and arylsulfatase activation; Defective F8 sulfation at Y1699","",302.3,292.8,286,266.2,271.7,232.7,1.1433947573319494,0.19332358038645772,0.047936264657702746,1.3193358105558277,0.238669045220129,0.6222039042519065,1468]
["O60711-1","Leupaxin [OS=Homo sapiens]",36,11,87,11,386,43.3,6.01,336.59,"cell adhesion;cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","LPXN","ENSG00000110031","","","",7734.9,7731.2,7423.2,7934.7,7964.5,9958.9,0.8851887803048174,-0.1759429296738577,0.2180310165771201,0.6614817202939419,0.47841149809731937,0.32019839110114573,3331]
["O60725","protein-s-isoprenylcysteine O-methyltransferase [OS=Homo sapiens]",6,2,3,2,284,31.9,7.96,7.07,"protein metabolism;other metabolic processes;transport","other membranes;ER/Golgi","other molecular function","ICMT","ENSG00000116237","Terpenoid backbone biosynthesis","RAS processing; Gamma carboxylation, hypusine formation and arylsulfatase activation","Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome",599.2,538.1,549.3,503.6,502.5,1101.3,0.8003226724874253,-0.3213463147104626,0.5223398727193859,0.28204682110716695,0.6832108320876864,0.16544525666533824,5588]
["O60733","85/88 kDa calcium-independent phospholipase A2 [OS=Homo sapiens]",1,1,1,1,806,89.8,7.27,2.59,"other metabolic processes;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component","other molecular function","PLA2G6","ENSG00000184381","Glycerophospholipid metabolism; Ether lipid metabolism; Arachidonic acid metabolism; Linoleic acid metabolism; alpha-Linolenic acid metabolism; Metabolic pathways; Ras signaling pathway; Vascular smooth muscle contraction; Fc gamma R-mediated phagocytosis; Inflammatory mediator regulation of TRP channels","Role of phospholipids in phagocytosis; COPI-independent Golgi-to-ER retrograde traffic; Acyl chain remodelling of PC; Acyl chain remodelling of PE; Acyl chain remodeling of CL","Eicosanoid synthesis; Spinal cord injury; Ras signaling; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Eicosanoid metabolism via cyclooxygenases (COX); Omega-3 / omega-6 fatty acid synthesis",174.1,162,178.1,191.3,201.7,76.9,1.0942753777399448,0.12997584243254054,0.732431981129091,0.13523270079216917,0.8276662569685415,0.08214475014255974,6468]
["O60749","Sorting nexin-2 [OS=Homo sapiens]",43,20,66,18,519,58.4,5.12,199.82,"cell organization and biogenesis;transport","other membranes;cytosol;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","SNX2","ENSG00000205302","Endocytosis","Golgi Associated Vesicle Biogenesis","",8167.2,8162.7,7947.7,7414.6,7304.2,6584.4,1.1396222163806378,0.18855565168643823,0.0213978882662972,1.669629084573584,0.16673471784474012,0.7779739610686754,938]
["O60759","cytohesin-interacting protein [OS=Homo sapiens]",12,2,3,2,359,40,6.99,8.96,"other biological processes","cytosol;nucleus;other cytoplasmic organelle;other cell component","","CYTIP","ENSG00000115165","","","Amplification and expansion of oncogenic pathways as metastatic traits",211.9,222.8,233.9,227.7,247.2,187.2,1.0098172481498264,0.014094224616633297,0.9136982374369842,0.03919721286007012,0.9437846830733349,0.025127075213782674,7076]
["O60762","Dolichol-phosphate mannosyltransferase subunit 1 [OS=Homo sapiens]",47,10,50,10,260,29.6,9.57,123.59,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","DPM1","ENSG00000000419","N-Glycan biosynthesis; Metabolic pathways","Synthesis of dolichyl-phosphate mannose; Defective DPM1 causes DPM1-CDG (CDG-1e); Defective DPM3 causes DPM3-CDG (CDG-1o); Defective DPM2 causes DPM2-CDG (CDG-1u)","VEGFA-VEGFR2 signaling pathway",6827.6,7992.3,6828.2,7693.1,6668,5618.6,1.0835047573286887,0.11570548786577156,0.47934419375134785,0.31935252882679865,0.653643043307575,0.18465935663559568,5360]
["O60763-1","General vesicular transport factor p115 [OS=Homo sapiens]",48,41,195,41,962,107.8,4.91,605.23,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","","USO1","ENSG00000138768","","COPI-mediated anterograde transport; COPII-mediated vesicle transport; Golgi Cisternae Pericentriolar Stack Reorganization","",21451.3,20729,20645.8,21250.5,21834.1,16130,1.0609900261084262,0.08541109418713082,0.5465594160113226,0.2623626193625212,0.7001056382100871,0.15483642479960583,5706]
["O60783","28S ribosomal protein S14, mitochondrial [OS=Homo sapiens]",12,1,3,1,128,15.1,11.41,11.73,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus","other molecular function","MRPS14","ENSG00000120333","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",39.2,36.6,37.2,31.4,43.4,77.3,0.7429322813938201,-0.4286973804219462,0.3973687084401082,0.40080633523036224,0.6054550531558789,0.21791809181228639,4797]
["O60784","Target of Myb protein 1 [OS=Homo sapiens]",57,19,81,19,492,53.8,4.7,205.96,"transport;signal transduction","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","TOM1","ENSG00000100284","","Neutrophil degranulation","",5476,5154.6,5069,4893,4972.1,6049.1,0.986515187694009,-0.01958683304936089,0.8643947632740406,0.06328787284857933,0.9139102162259458,0.03909646784703969,6913]
["O60825-1","6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 [OS=Homo sapiens]",46,19,72,1,505,58.4,8.38,198.67,"other metabolic processes;other biological processes","cytosol;nucleus","kinase activity;other molecular function","PFKFB2","ENSG00000123836; ENSGGOG00000012227; ENSPPAG00000041619; ENSPTRG00000001925","Fructose and mannose metabolism; Metabolic pathways; AMPK signaling pathway; Thyroid hormone signaling pathway","Regulation of glycolysis by fructose 2,6-bisphosphate metabolism","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Thyroid hormones production and peripheral downstream signaling effects",5027.3,5247.3,4837,5229.1,4670.4,5312.8,0.9933803566850509,-0.009581875989456786,0.8928291207850954,0.0492316530950894,0.9303803883402141,0.03133945275660021,7014]
["O60825-2","Isoform 2 of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 [OS=Homo sapiens]",50,19,71,1,471,54.4,7.56,198.67,"","","","PFKFB2","","","","",154.5,137.6,136.2,125.4,114.2,134.1,1.1461065025421462,0.1967411135102979,0.0915188757860807,1.038489323372952,0.32566283501483145,0.4872318007502384,2054]
["O60826","Coiled-coil domain-containing protein 22 [OS=Homo sapiens]",26,14,30,14,627,70.7,6.74,85.37,"transport;other biological processes","cytosol;nucleus;other cytoplasmic organelle","other molecular function","CCDC22","ENSG00000101997","","Neddylation","",2577.2,2485.6,2422.1,2573.7,2576.3,2127.6,1.0284846652742663,0.04052028341297013,0.6802903138495291,0.1673057125932293,0.7932740752913543,0.1005767385058088,6268]
["O60828","Polyglutamine-binding protein 1 [OS=Homo sapiens]",19,4,9,4,265,30.5,6.33,27.86,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","PQBP1","ENSG00000102103","Spliceosome","mRNA Splicing - Major Pathway","",866.8,724.1,634,937,943.8,1001.3,0.771971826099025,-0.37337989906359864,0.03638840111428152,1.4390370266478947,0.2102472914974574,0.6772695902757585,1265]
["O60830-1","Mitochondrial import inner membrane translocase subunit Tim17-B [OS=Homo sapiens]",30,5,15,5,172,18.3,9.03,43.72,"cell organization and biogenesis;transport","other membranes;mitochondrion","transporter activity","TIMM17B","ENSG00000126768; ENSGGOG00000011427; ENSNLEG00000007902; ENSPPAG00000036547; ENSPPYG00000020323; ENSPTRG00000021872","","Mitochondrial protein import","",1918,1771.1,1869.5,1912.9,2016.6,1980.8,0.9404937143630611,-0.08850979312458432,0.09075527878682291,1.042128104789768,0.32452560305914313,0.4887510343684701,2044]
["O60831","PRA1 family protein 2 [OS=Homo sapiens]",22,3,7,3,178,19.2,9.19,15.69,"transport","other membranes;other cytoplasmic organelle","","PRAF2","ENSG00000243279","","","",353.3,383.9,363.6,325.1,345,536.4,0.9123912142561128,-0.13227554040101563,0.6315046530568735,0.19962344512531027,0.7626681277582104,0.11766440259248638,6052]
["O60832-1","H/ACA ribonucleoprotein complex subunit 4 [OS=Homo sapiens]",53,27,113,27,514,57.6,9.42,378.31,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DKC1","ENSG00000130826; ENSGGOG00000001045; ENSPTRG00000022449","Ribosome biogenesis in eukaryotes","rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase","",16848.5,17824.4,17376,17538.2,16910.5,17734.1,0.9974340204051911,-3.706683710260512E-3,0.9111900621454011,0.04039102551691705,0.942125925055982,0.02589104529424302,7069]
["O60841","Eukaryotic translation initiation factor 5B [OS=Homo sapiens]",41,55,214,54,1220,138.7,5.49,606.45,"protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","EIF5B","ENSG00000158417","","GTP hydrolysis and joining of the 60S ribosomal subunit","Translation factors; Ciliary landscape",28896.6,28535.8,28109.2,28722.6,29131.3,18313.4,{"$f":"AVERAGE(S514:U514)/AVERAGE(V514:X514)","v":1.1230751254147122},{"$f":"LOG(Y514,2)","v":0.16745443658816397},{"$f":"TTEST(V514:X514,S514:U514,2,2)","v":0.4281061060544159},0.368448577802627,{"$f":"AA514*7309/AE514","v":0.6225681514428424},0.20581310017521126,5026]
["O60861-1","Isoform 1 of Growth arrest-specific protein 7 [OS=Homo sapiens]",7,2,3,2,412,47.2,7.58,8.59,"","","","GAS7","","","","",286.4,251.7,305.7,580.2,576.6,168,0.6369263285024153,-0.6508015852799747,0.30902691794410864,{"$f":"-LOG10(AA515)","v":0.5100036894896299},0.5578359454812275,{"$f":"-LOG10(AC515)","v":0.2534935043740704},4049]
["O60869-1","Endothelial differentiation-related factor 1 [OS=Homo sapiens]",10,1,1,1,148,16.4,9.95,2.52,"developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","EDF1; LOC101354658; LOC113248658","ENSBIXG00000009641; ENSBIXG00005005090; ENSBTAG00000030302; ENSCATG00000040060; ENSCCAG00000020655; ENSCJAG00000011166; ENSCSAG00000016077; ENSECAG00000012630; ENSFCAG00000000388; ENSG00000107223; ENSLCNG00005013346; ENSPANG00000026162; ENSPCOG00000009350; ENSRFEG00010005371","","","",257.5,250.7,240.6,225.5,236.7,207.8,1.1176119402985074,0.16041933935090735,0.05428307757957587,1.2653355379847009,0.253517580849278,0.5959919179831951,1565]
["O60870","DNA/RNA-binding protein KIN17 [OS=Homo sapiens]",13,5,13,5,393,45.3,8.95,36.4,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response","nucleus;other cell component","nucleic acid binding activity;other molecular function","KIN","ENSG00000151657","","Protein methylation","",719.9,748.9,701.9,1031.1,998.5,1108,0.6918345232024478,-0.5315010875219224,7.9237398028606312E-4,3.101069794117486,0.03939769674769276,1.404529166981689,147]
["O60879-2","Isoform 2 of Protein diaphanous homolog 2 [OS=Homo sapiens]",18,20,36,18,1096,124.7,6.43,109.53,"","","","DIAPH2","","","","",3883.3,3654.7,3758.2,3666.3,3801.7,2043.3,1.1876609927139299,0.2481230904095883,0.35458177508845523,0.4502835901731211,0.5860782890369786,0.23204436653184327,4422]
["O60884","DnaJ homolog subfamily A member 2 [OS=Homo sapiens]",37,14,52,14,412,45.7,6.48,156.08,"stress response;other biological processes","other membranes;cytosol","other molecular function","DNAJA2","ENSG00000069345","Protein processing in endoplasmic reticulum","HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand","",6425.5,6396.5,6074.1,6382.7,6463.7,6425.5,0.9805001063724904,-0.028410307954837545,0.33732139617472073,0.4719561107944716,0.5745705161130352,0.24065666344317044,4291]
["O60885-1","Bromodomain-containing protein 4 [OS=Homo sapiens]",4,5,6,5,1362,152.1,9.19,12.26,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","kinase activity;other molecular function","BRD4","ENSG00000141867; ENSPTRG00000010619","","Potential therapeutics for SARS","VEGFA-VEGFR2 signaling pathway; 7q11.23 copy number variation syndrome",346.2,398.3,342.2,2149.6,2182.1,1282.2,0.19357309535260694,-2.369049647949961,6.9288643752317075E-3,2.1593379394119996,0.10028330637340306,0.9987713556466881,505]
["O60888-1","Protein CutA [OS=Homo sapiens]",47,5,48,5,179,19.1,5.5,156.55,"other biological processes","other membranes","other molecular function","CUTA","ENSG00000112514; ENSG00000226492","","","",2241.8,2359.9,3071.4,2634.6,3118.3,2518.3,0.9276888480510688,-0.10828709626576123,0.5642620338541675,0.2485191700778807,0.7120495865746046,0.1474897613829983,5792]
["O60906","Sphingomyelin phosphodiesterase 2 [OS=Homo sapiens]",6,2,3,2,423,47.6,6.98,6.62,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","SMPD2","ENSG00000135587","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway","Glycosphingolipid metabolism; Ceramide signalling; TNFR1-mediated ceramide production","TNF-alpha signaling pathway; S1P receptor signal transduction",79.5,71.6,79.4,55.9,68.3,219.4,0.6708381839348078,-0.5759632858217635,0.5133170686702417,0.2896142944650245,0.6777157613639445,0.16895241402975295,5536]
["O60907","F-box-like/WD repeat-containing protein TBL1X [OS=Homo sapiens]",14,7,25,2,577,62.5,6.55,91.11,"protein metabolism;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","TBL1X","ENSG00000101849","Wnt signaling pathway","Heme signaling; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; RORA activates gene expression","Ectoderm differentiation; Ectoderm differentiation; Rett syndrome causing genes",45.6,57,52.2,63.8,61,102.8,0.6801405975395431,-0.5560950861621715,0.15554314757516585,0.8081491168975798,0.4119075600097417,0.38520023707882456,2760]
["O60921","checkpoint protein HUS1 [OS=Homo sapiens]",20,4,9,4,280,31.7,6.84,31.78,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","","HUS1","ENSG00000136273","Cellular senescence","Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA)","ATR signaling",363.8,394.1,364.7,358.7,362,307.9,1.0913863503791563,0.1261619056094833,0.19475350734349456,0.7105147123141409,0.4528963999916009,0.34400113144774797,3143]
["O60925","prefoldin subunit 1 [OS=Homo sapiens]",8,1,1,1,122,14.2,6.81,3.51,"other biological processes","other cell component","other molecular function","PFDN1","ENSG00000113068","","Prefoldin mediated transfer of substrate  to CCT/TriC","Cellular proteostasis",107.9,128.6,155.6,134.5,170.2,154.9,0.8531331592689295,-0.22915715612952386,0.26215631940505396,0.5814396689452416,0.5195500375627818,0.2843726194428603,3688]
["O60927","Protein phosphatase 1 regulatory subunit 11 [OS=Homo sapiens]",12,1,2,1,126,13.9,7.01,8.98,"protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","enzyme regulator activity;other molecular function","PPP1R11","ENSG00000204619; ENSG00000206501; ENSG00000227720; ENSG00000233314; ENSG00000234058; ENSG00000236560; ENSG00000237403; ENSG00000237829","","","",106.1,116.9,100.8,154.3,154.1,211.2,0.6231716705157815,-0.682298445145315,0.02902336186151587,1.537252283375135,0.19042347562461356,0.7202795123288721,1114]
["O60930","Ribonuclease H1 [OS=Homo sapiens]",7,2,3,2,286,32,9.16,10.07,"RNA metabolism OR transcription;other metabolic processes","other cell component","nucleic acid binding activity;other molecular function","RNASEH1","ENSG00000171865","DNA replication","","",438.3,412.4,386.1,415.2,389.8,467.9,0.971639563202137,-0.041506860087044815,0.6842502582877386,0.16478502998226194,0.7958601428747742,0.09916324446622468,6284]
["O60934","Nibrin [OS=Homo sapiens]",12,7,14,7,754,84.9,6.9,28.06,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NBN","ENSG00000104320","Homologous recombination; Cellular senescence","Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks","miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM signaling in development and disease ; Breast cancer pathway; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; DNA damage response",1218.8,1243.2,1198.9,1486.5,1639.8,1418.9,0.8054431048138695,-0.31214541197897716,0.011453503633360394,1.9410616420681266,0.12683887584277442,0.8967476157260224,660]
["O60942-1","mRNA-capping enzyme [OS=Homo sapiens]",19,10,25,10,597,68.5,8.13,62.35,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","RNGTT","ENSG00000111880; ENSGGOG00000007863; ENSNLEG00000013064; ENSPPAG00000024828; ENSPTRG00000018413","mRNA surveillance pathway","RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE","mRNA processing; Ciliary landscape; mRNA Processing",1822.4,1793.4,1793.9,1834.7,1902.7,2316.3,0.8936187785982126,-0.1622685918035346,0.2276572264049958,0.6427185595530106,0.4878178445599866,0.31174231707643485,3411]
["O75027-1","ATP-binding cassette sub-family B member 7, mitochondrial [OS=Homo sapiens]",26,17,33,16,752,82.6,9.33,94.31,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","ABCB7","ENSG00000131269","ABC transporters","Mitochondrial ABC transporters; Cytosolic iron-sulfur cluster assembly","",3717.1,3104.6,3786.2,2939,3176.3,3174.4,1.1418990925433543,0.19143516810937378,0.129281653013134,0.8884631035845492,0.37857355844270685,0.42184972271096255,2496]
["O75037","Kinesin-like protein KIF21B [OS=Homo sapiens]",8,10,15,9,1637,182.5,7.08,40.29,"other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF21B","ENSG00000116852","","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","",863.9,842.2,848.5,1111.7,1013.6,2361,0.5694224639457904,-0.8124286857834472,0.21185176216377483,0.6739679192257918,0.4715056424040896,0.326513105789222,3284]
["O75044","SLIT-ROBO Rho GTPase-activating protein 2 [OS=Homo sapiens]",31,28,60,28,1071,120.8,6.7,171.11,"","","","","","","","",7359.1,7541,7523.9,6965.9,6721.1,6491.6,1.1112763026176247,0.15221756637286696,0.007318769012449556,2.135561959386642,0.1032681133436174,0.9860337572479021,518]
["O75052","Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein [OS=Homo sapiens]",12,5,15,4,506,56.1,6.3,29.74,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","NOS1AP","ENSG00000198929","Circadian entrainment","","Sudden infant death syndrome (SIDS) susceptibility pathways",396.3,410.4,404,401.4,400,780.2,0.7654906423874558,-0.3855433530391472,0.38396548629615274,0.4157078115303278,0.5982527689913836,0.2231152825935132,4691]
["O75063","Glycosaminoglycan xylosylkinase [OS=Homo sapiens]",15,5,12,5,409,46.4,6.87,36.6,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;nucleus","kinase activity;other molecular function","FAM20B","ENSG00000116199","","","",828.2,848.4,835.6,863.6,888.8,1116.4,0.875697155605131,-0.1914960694069167,0.21435332028905899,0.6688697849686106,0.47447256753262634,0.3237888920114125,3302]
["O75064","DENN domain-containing protein 4B [OS=Homo sapiens]",4,5,8,5,1496,163.7,7.21,29.61,"other biological processes","cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity","DENND4B","ENSG00000198837","","RAB GEFs exchange GTP for GDP on RABs","",496.1,561.9,538,523.3,483.8,1231.7,0.7128819010184027,-0.4882650012859445,0.4290051234677545,0.36753752114747357,0.6227603669167463,0.20567903415313737,5035]
["O75071","EF-hand calcium-binding domain-containing protein 14 [OS=Homo sapiens]",3,2,2,2,495,55,6.32,2.24,"","","other molecular function","EFCAB14","ENSG00000159658","","","",185.4,204.8,157.3,210.3,222.6,379.4,0.6740120645081866,-0.5691536796666437,0.19106746667362431,0.7188132545825631,0.4496175511646877,0.34715674409112984,3106]
["O75083","WD repeat-containing protein 1 [OS=Homo sapiens]",66,28,263,28,606,66.2,6.65,1018.95,"cell organization and biogenesis;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity","WDR1","ENSG00000071127","","Platelet degranulation","Hypertrophy model",29252.1,31507.2,30781.5,28306.9,25728,25594,1.1495926730119344,0.20112277184609767,0.02289575324024587,1.6402450641825286,0.17198875686840398,0.7644999425669075,973]
["O75093-1","Slit homolog 1 protein [OS=Homo sapiens]",1,1,1,1,1534,167.8,6.57,1.87,"cell organization and biogenesis;transport;developmental processes;other biological processes","non-structural extracellular","signal transduction activity or receptor binding;other molecular function","SLIT1","ENSG00000187122","Axon guidance","Regulation of expression of SLITs and ROBOs; Netrin-1 signaling; Regulation of cortical dendrite branching; Regulation of commissural axon pathfinding by SLIT and ROBO","Spinal cord injury",255.2,258.9,250.6,273.9,262.7,391.5,0.823941385626549,-0.2793863857236301,0.25731675007445853,0.5895319424016338,0.5148448196808698,0.2883236527295775,3653]
["O75113","NEDD4-binding protein 1 [OS=Homo sapiens]",19,12,17,12,896,100.3,5.36,60.04,"RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","N4BP1","ENSG00000102921","","","",943.4,974.1,893.4,937.6,904.2,834.9,1.0501363619382074,0.07057667638539067,0.3078156844674381,0.5117092548615394,0.5566117856933462,0.2544476021568516,4042]
["O75116","Rho-associated protein kinase 2 [OS=Homo sapiens]",29,34,65,28,1388,160.8,6.02,166.7,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;kinase activity;other molecular function","ROCK2","ENSG00000134318","cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Vascular smooth muscle contraction; Wnt signaling pathway; Axon guidance; Focal adhesion; Tight junction; Platelet activation; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Human cytomegalovirus infection; Pathways in cancer; Proteoglycans in cancer; Lipid and atherosclerosis","RHOA GTPase cycle; RHOB GTPase cycle; RHOC GTPase cycle; G alpha (12/13) signalling events; Potential therapeutics for SARS; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHOBTB1 GTPase cycle; RHOH GTPase cycle","Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Pathogenic Escherichia coli infection; Spinal cord injury; Focal adhesion; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; Wnt signaling; Airway smooth muscle cell contraction; Regulation of actin cytoskeleton; G13 signaling pathway",5156.3,5237.3,5292.3,5494.7,5485.7,4088.7,1.040931442488271,0.05787505342193496,0.6836479233573234,0.16516750107105221,0.796173147198642,0.0989924741019783,6276]
["O75122","CLIP-associating protein 2 [OS=Homo sapiens]",29,29,71,1,1294,141,8.47,187.27,"","","","","","","","",16.1,20.8,15.2,16,21.4,30.2,0.7707100591715978,-0.37573987400367564,0.3137406211839076,0.5034292479139518,0.5606675306193596,0.2512945940373207,4090]
["O75122-3","Isoform 3 of CLIP-associating protein 2 [OS=Homo sapiens]",24,29,71,1,1515,165.8,8.37,188.79,"","","","","","","","",5219.6,5323.9,5348.8,5824.7,5843.1,7082.7,0.8475667315538252,-0.2386011343177576,0.0849457729432108,1.0708582275437708,0.31484211685696134,0.5019071762649903,1972]
["O75127","pentatricopeptide repeat-containing protein 1, mitochondrial [OS=Homo sapiens]",15,8,17,8,700,78.8,8.59,43.17,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","nucleic acid binding activity","PTCD1","ENSG00000106246","","","",1442.5,1464.7,1416,1658.4,1671.1,1816.2,0.840157801659638,-0.2512677690310728,0.006433981226126061,2.191520210670877,0.09736225420653287,1.0116093795384162,483]
["O75131","Copine-3 [OS=Homo sapiens]",46,20,84,19,537,60.1,5.85,274.59,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","CPNE3","ENSG00000085719","","Neutrophil degranulation; Glycerophospholipid biosynthesis","",10447.1,10311.1,10656.9,9807.3,9514,11112.7,1.0322369718078463,0.04577420991459901,0.5499459313414901,0.2596800066408745,0.7025965411947126,0.15329399252256956,5721]
["O75132","Zinc finger BED domain-containing protein 4 [OS=Homo sapiens]",2,2,2,2,1171,130.2,6.83,7.41,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBED4","ENSG00000100426","","","",133.5,132.2,128.5,140.7,137,218.8,0.7939577039274924,-0.3328659413722505,0.27084935256425696,0.5672721982089796,0.5245463481431251,0.28021613215391916,3774]
["O75140-1","Isoform 1 of GATOR complex protein DEPDC5 [OS=Homo sapiens]",8,9,10,9,1572,177.8,6.73,33.77,"","","","DEPDC5","","","","",658.3,679.3,663.1,700.4,665.7,851.7,0.9021101992966001,-0.14862441499008022,0.27631618251069956,0.5585936797982958,0.5299383306141965,0.2757746666864901,3811]
["O75143-1","Autophagy-related protein 13 [OS=Homo sapiens]",17,5,9,5,517,56.5,5.12,27.52,"cell organization and biogenesis;other metabolic processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cell component","other molecular function","ATG13","ENSG00000175224","Autophagy; Autophagy; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration","Macroautophagy","Alzheimer's disease and miRNA effects; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Host-pathogen interaction of human coronaviruses - autophagy; Autophagy; Malignant pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; Senescence and autophagy in cancer",705.2,719.4,710.8,939.2,911.7,1145.8,0.712583842226449,-0.4888683240235823,0.017839879106874755,1.7486080929753156,0.15449250757363459,0.8110925777169976,844]
["O75144-1","ICOS ligand [OS=Homo sapiens]",4,1,1,1,302,33.3,5.31,2.94,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","ICOSLG","ENSG00000160223","Cell adhesion molecules; Intestinal immune network for IgA production","Costimulation by the CD28 family","",88.9,96.5,81.4,88.8,92.6,147,0.8124238733252133,-0.2996954605932196,0.3472781605814794,0.4593225274787006,0.5800402366750532,0.23654187892010203,4376]
["O75145-1","Liprin-alpha-3 [OS=Homo sapiens]",1,2,2,1,1194,133.4,5.68,4.59,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","non-structural extracellular;cytosol;other cell component","","PPFIA3","ENSG00000177380","","Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Receptor-type tyrosine-protein phosphatases","",292.3,308.8,299.8,330,301.1,639.1,0.7092583845063769,-0.4956167944504397,0.31906799003807645,0.4961167634879089,0.5638462135368232,0.24883933168982203,4136]
["O75146","Huntingtin-interacting protein 1-related protein [OS=Homo sapiens]",25,25,37,25,1068,119.3,6.67,110.28,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component","cytoskeletal activity;other molecular function","HIP1R","ENSG00000130787","","Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis","",3445.8,3449.7,3439.7,3500.6,3424.6,5411.7,0.8377469218361178,-0.25541361439456206,0.36271941132899027,0.4404292020498765,0.5886137161198024,0.23016962200919336,4504]
["O75150","E3 ubiquitin-protein ligase BRE1B [OS=Homo sapiens]",39,36,87,33,1001,113.6,6.23,274.24,"protein metabolism;other metabolic processes","nucleus","other molecular function","RNF40","","","","",7340.7,7574.5,7462.4,7649.3,7730.5,8338.4,0.9434780042330363,-0.08393921092896746,0.12117175320080807,0.9165986083773435,0.36978887020655793,0.4320461642439526,2395]
["O75151","lysine-specific demethylase phf2 [OS=Homo sapiens]",7,6,6,6,1096,120.7,9.17,14.18,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","other molecular function","PHF2","ENSG00000197724","","HDMs demethylate histones","",298.5,291.8,262.2,321.9,347,450.6,0.7615006699419383,-0.39308278894106274,0.09537577893377254,1.0205619021405201,0.33116464048785915,0.4799560404282343,2105]
["O75152","Zinc finger CCCH domain-containing protein 11A [OS=Homo sapiens]",35,26,48,26,810,89.1,8.37,125.72,"other metabolic processes;transport","nucleus","nucleic acid binding activity;other molecular function","ZC3H11A","ENSG00000058673","","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","",5823.9,5603.4,5828.6,6431.8,6612.9,5477.3,0.9316434510312062,-0.10215016774154993,0.3061267643114414,0.5140986988749376,0.5552060844546713,0.2555457831320741,4030]
["O75153","Clustered mitochondria protein homolog [OS=Homo sapiens]",24,22,46,22,1309,146.6,6.13,135.35,"cell organization and biogenesis","other cell component","nucleic acid binding activity","CLUH","ENSG00000132361","","","Translation factors",4411.5,4394.7,4463.2,6413.4,6103.6,4640.8,0.77337420881465,-0.37076144196862426,0.07685571895517442,1.1143238104249544,0.30266080271733287,0.5190438204238247,1856]
["O75157","TSC22 domain family protein 2 [OS=Homo sapiens]",6,5,11,3,780,79.2,5.02,19.03,"stress response;other biological processes","","","TSC22D2","ENSG00000196428","","","",622.7,568.8,587.7,571.1,605.2,538.3,1.0376764259885687,0.05335664466200497,0.4367170439313017,0.3597998583629047,0.6263667335349066,0.20317131580622574,5096]
["O75164-1","Lysine-specific demethylase 4A [OS=Homo sapiens]",12,9,18,9,1064,120.6,5.85,58.62,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","KDM4A","ENSG00000066135","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux","",1022.5,994.5,970.3,1137.1,1113.6,1404.9,0.8171845935003831,-0.291266089898597,0.07818627968106961,1.106869451308321,0.3041317286795837,0.5169382695248738,1879]
["O75165","DnaJ homolog subfamily C member 13 [OS=Homo sapiens]",30,57,155,57,2243,254.3,6.74,473.49,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","","DNAJC13","ENSG00000138246","","Neutrophil degranulation","",15043.5,15225.2,15236.9,14905.2,14569.8,18052.4,0.9574603281475528,-0.06271538390251963,0.5768480628507882,0.23893856146256479,0.7207149557908393,0.14223646566077233,5850]
["O75167","Phosphatase and actin regulator 2 [OS=Homo sapiens]",2,2,2,1,634,69.7,8.16,3.9,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes","enzyme regulator activity;cytoskeletal activity","PHACTR2","ENSG00000112419","","Platelet degranulation","",46,57.5,48,52.1,47.1,204.9,0.498191384413022,-1.0052280226704846,0.38260144393104484,0.4172533952859793,0.5976563269271226,0.22354847859418667,4679]
["O75170","Serine/threonine-protein phosphatase 6 regulatory subunit 2 [OS=Homo sapiens]",25,14,27,14,966,104.9,4.87,59.4,"other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PPP6R2","ENSG00000100239","","","",991.8,960.7,959.9,1037.9,1065.8,952.8,0.9528545722231311,-0.06967205277991824,0.24824414066675954,0.6051209934111305,0.5073871432140228,0.2946605416510376,3576]
["O75175","CCR4-NOT transcription complex subunit 3 [OS=Homo sapiens]",7,5,14,5,753,81.8,6.2,35.81,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","","CNOT3","ENSG00000088038; ENSG00000273943; ENSG00000274176; ENSG00000274616; ENSG00000274941; ENSG00000275979; ENSG00000276082; ENSG00000277114; ENSG00000277600; ENSG00000277615","RNA degradation","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","",913.8,944.8,919.3,1192.6,1226.6,1051.6,0.8003630286965542,-0.321273568758214,0.013217904088666403,1.878837403767908,0.13455384538170298,0.8711038861262353,718]
["O75177","Calcium-responsive transactivator [OS=Homo sapiens]",6,2,2,2,396,43,6.44,5.82,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","SS18L1","ENSG00000184402","","","",182.1,163.7,172.2,218.1,211.6,225.2,0.7909604519774012,-0.3383225331380309,2.3087593454977884E-3,2.636621333591808,0.06091957421026475,1.2152431407722837,277]
["O75179-1","Ankyrin repeat domain-containing protein 17 [OS=Homo sapiens]",14,29,48,17,2603,274.1,6.52,133.09,"stress response;developmental processes;other biological processes","other membranes;nucleus;other cell component","other molecular function","ANKRD17","ENSG00000132466","","","",4153.4,4296,4199.4,4840.6,4741.1,4272.8,0.9129741239308526,-0.1313541238406958,0.0893699516560049,1.0488084769935246,0.32241114346186567,0.49158995613381334,2026]
["O75182-2","Isoform 2 of Paired amphipathic helix protein Sin3b [OS=Homo sapiens]",8,6,10,5,1130,129.3,6.98,26.85,"","","","SIN3B","","","","",154.1,198.5,169.5,191.9,203.3,184.1,0.9012601415501467,-0.14998450632387875,0.24936746117792208,0.6031602162656917,0.508403563110023,0.29379141438553763,3585]
["O75190","DnaJ homolog subfamily B member 6 [OS=Homo sapiens]",30,8,18,7,326,36.1,9.16,53.64,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","DNAJB6","ENSG00000105993","","Regulation of HSF1-mediated heat shock response","",1763.1,1780.1,1723.4,1596.8,1618.9,1495.7,1.1178418304537932,0.16071606782052583,0.011144924483592255,1.9529228698908128,0.12570718063360461,0.9006399138774333,648]
["O75191","xylulose kinase [OS=Homo sapiens]",4,2,2,2,536,58.3,5.86,6.13,"other metabolic processes","cytosol","kinase activity;other molecular function","XYLB","ENSG00000093217","Pentose and glucuronate interconversions; Metabolic pathways","Formation of xylulose-5-phosphate","",166.9,179.8,183,161.6,138.9,299.8,0.8823921372647011,-0.1805081593295115,0.6655712466755201,0.17680544825562608,0.7851291546080337,0.10505889545882151,6196]
["O75208-1","Ubiquinone biosynthesis protein COQ9, mitochondrial [OS=Homo sapiens]",18,4,13,4,318,35.5,5.94,59.67,"other metabolic processes","other membranes;mitochondrion","other molecular function","COQ9","ENSG00000088682","","Ubiquinol biosynthesis","",867.6,764,839.4,644.7,741.2,613.2,1.2360562253013856,0.3057443695518069,0.03337197232635559,1.4766181252259372,0.20292491325568468,0.692664631008685,1202]
["O75223-1","gamma-glutamylcyclotransferase [OS=Homo sapiens]",54,9,45,9,188,21,5.14,115.66,"cell organization and biogenesis;signal transduction","cytosol","other molecular function","C7orf24; GGCT","ENSG00000006625; ENSGGOG00000024930; ENSPPAG00000031715; ENSPTRG00000019041","Glutathione metabolism; Metabolic pathways","Glutathione synthesis and recycling","Gamma-glutamyl cycle for the biosynthesis and degradation of glutathione, including diseases",5149.1,5457.2,5398,5184.2,4634.5,3910,1.1657549513063872,0.22126455724375302,0.11723469816469316,0.930943830372484,0.36431479969631897,0.43852318589261186,2352]
["O75251","NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [OS=Homo sapiens]",14,3,27,3,213,23.5,9.99,53.49,"cell organization and biogenesis;other metabolic processes;transport","plasma membrane;other membranes;mitochondrion;other cell component","transporter activity;other molecular function","NDUFS7","ENSG00000115286","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",2826.6,2998.6,2659.5,2800.9,2771.1,5203.5,0.7874066168623266,-0.3448192588517304,0.4001558497598189,0.39777082990124807,0.6079274799198745,0.2161482249198393,4811]
["O75306-1","NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [OS=Homo sapiens]",47,17,73,17,463,52.5,7.55,235.08,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion;nucleus","transporter activity;other molecular function","NDUFS2","ENSG00000158864","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",7763.7,7680.2,7981.2,7397.9,6906.8,7210.3,1.0887799209853588,0.12271236636861896,0.019602004877143298,1.7076995070847942,0.1609787119629667,0.793231551845734,890]
["O75312","Zinc finger protein ZPR1 [OS=Homo sapiens]",45,15,37,15,459,50.9,4.73,120.57,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ZPR1","ENSG00000109917","","","",3508.4,3113.1,3421.6,3652.9,4076.2,4109.1,0.8483637715193189,-0.2372450814745731,0.03434044108326557,1.4641941308757997,0.20489329296129635,0.688472257692378,1225]
["O75323-1","Protein NipSnap homolog 2 [OS=Homo sapiens]",24,6,16,5,286,33.7,9.36,44.31,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;mitochondrion","","NIPSNAP2","ENSG00000146729","","RHOJ GTPase cycle; RHOH GTPase cycle","",1474.1,1459.5,1447,1410.5,1400.6,1710.6,0.9687949222637504,-0.045736791420050514,0.6687498001759304,0.174736334738945,0.7867201496033921,0.10417972646808712,6213]
["O75330-1","Hyaluronan mediated motility receptor [OS=Homo sapiens]",36,25,38,24,724,84,5.83,108.57,"","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","HMMR","ENSG00000072571","ECM-receptor interaction","AURKA Activation by TPX2; Hyaluronan uptake and degradation","",4176.5,4110.9,3996.7,3954.1,4134.7,4218.1,0.9981473807376348,-0.002675243492155665,0.9394238090945243,0.027138437097907694,0.9612555817824272,0.017161125338477058,7143]
["O75335-1","Isoform 1 of Liprin-alpha-4 [OS=Homo sapiens]",1,1,1,1,701,78,7.28,2.27,"","","","PPFIA4","","","","",192.1,202,194,176.2,171,354.6,0.8379880307779995,-0.25499845724023446,0.5645553417628713,0.2482934789929154,0.7120509047359492,0.14748895740855728,5795]
["O75340","programmed cell death protein 6 [OS=Homo sapiens]",40,6,30,6,191,21.9,5.4,63.06,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PDCD6","ENSG00000249915","","","Epithelial to mesenchymal transition in colorectal cancer",4449.7,4306.6,4909.4,4434.6,4718.8,5267,0.9476644198496572,-0.07755182218647548,0.4551887949629778,0.3418084371789839,0.6380849448378222,0.19512150212732104,5214]
["O75347","Tubulin-specific chaperone A [OS=Homo sapiens]",34,5,6,5,108,12.8,5.29,13.87,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","TBCA","ENSG00000171530","","Post-chaperonin tubulin folding pathway","VEGFA-VEGFR2 signaling pathway",924.2,888.1,804.7,662.4,642.2,1172.1,1.056647958977672,0.0794947973131869,0.8046012910716166,0.0944192748907468,0.8764278444772646,0.057283833175765915,6710]
["O75348","V-type proton ATPase subunit G 1 [OS=Homo sapiens]",7,1,1,1,118,13.7,8.79,1.8,"transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle","transporter activity;other molecular function","ATP6V1G1","ENSG00000136888","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis","Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Osteoclast signaling; Proximal tubule transport",213.8,223.8,200.6,155.7,174,213.7,1.174457121825543,0.23199404305733737,0.16086513391077278,0.7935380751738211,0.4187191110234467,0.3780772167476158,2808]
["O75351","Vacuolar protein sorting-associated protein 4B [OS=Homo sapiens]",58,20,82,16,444,49.3,7.23,209.91,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","VPS4B","ENSG00000119541","Endocytosis; Necroptosis","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)","",9221,8988.2,8937.6,9435,9482.8,7210.3,1.038988675028035,0.055179928958259086,0.6760716303433553,0.17000728776427582,0.7908782884410346,0.10189034674954674,6248]
["O75352","Mannose-P-dolichol utilization defect 1 protein [OS=Homo sapiens]",10,2,24,2,247,26.6,8.94,56.6,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","","MPDU1","ENSG00000129255","","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective MPDU1 causes CDG-1f","",1522.9,1624.4,1589.3,1346.7,1400.8,1769.4,{"$f":"AVERAGE(S578:U578)/AVERAGE(V578:X578)","v":1.048639553676194},{"$f":"LOG(Y578,2)","v":0.06851886906368532},{"$f":"TTEST(V578:X578,S578:U578,2,2)","v":0.619059066419815},0.20826791156732624,{"$f":"AA578*7309/AE578","v":0.7531129687853575},0.12313987367946526,6008]
["O75354-1","Ectonucleoside triphosphate diphosphohydrolase 6 [OS=Homo sapiens]",2,1,2,1,484,53.2,9.26,6.59,"other metabolic processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","ENTPD6","ENSG00000197586","Purine metabolism; Pyrimidine metabolism; Metabolic pathways","Phosphate bond hydrolysis by NTPDase proteins","",92.5,91,98.4,107.4,101.6,173.9,0.7362235570645077,-0.4417841822797389,0.222049636322719,{"$f":"-LOG10(AA579)","v":0.6535499337858047},0.48288033081902804,{"$f":"-LOG10(AC579)","v":0.3161604843713093},3361]
["O75362","zinc finger protein 217 [OS=Homo sapiens]",5,5,5,4,1048,115.2,8.48,14.96,"other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","ZNF217","ENSG00000171940","","Estrogen-dependent gene expression","",306.4,231.8,289,679.9,793.7,323,0.4604252476900813,-1.118961148214416,0.08757823388917187,1.0576038170785913,0.31941582409977903,0.4956435723898265,2004]
["O75367-1","Core histone macro-H2A.1 [OS=Homo sapiens]",48,16,177,16,372,39.6,9.79,596.35,"cell organization and biogenesis;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","H2afy; H2AFY; LOC100466888; LOC101338325; LOC101381952; LOC101564704; LOC102987354; LOC103079324; LOC103663804; LOC106989149; LOC109250833; LOC110591142; LOC111141291; LOC111182462; LOC112404331; LOC112815157; LOC112861289; LOC112917035; LOC113261754; LOC113928700; LOC115516119; LOC116529369; MACROH2A1","ENSAMEG00000017887; ENSCAFG00000001076; ENSCANG00000022762; ENSCJAG00000005818; ENSFCAG00000013924; ENSG00000113648; ENSGGOG00000001707; ENSLCNG00005003680; ENSMLEG00000037795; ENSMNEG00000031666; ENSMPUG00000010011; ENSPCOG00000013464; ENSPCTG00005011747; ENSPPAG00000029258; ENSPTRG00000017256; ENSRBIG00000034425; ENSRROG00000045755; ENSSBOG00000034640; ENSSSUG00005001976; ENSVVUG00000017487","Necroptosis; Neutrophil extracellular trap formation; Alcoholism; Systemic lupus erythematosus","","H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma",27658.3,25715.8,26996,24213.7,25486.6,17375.4,1.1981999442421025,0.2608686714802729,0.16128075472830258,0.7924174529083645,0.4189058409058862,0.3778835841231184,2814]
["O75368","SH3 domain-binding glutamic acid-rich-like protein [OS=Homo sapiens]",29,5,14,5,114,12.8,5.25,36.43,"","nucleus;other cell component","other molecular function","SH3BGRL","ENSG00000131171","","","",2757.4,2686.8,2697.1,2685.8,2709.4,3673.7,0.8977163713350019,-0.155668389678489,0.39683854691042475,0.40138614927639943,0.6048994659787893,0.21831679889910882,4795]
["O75369-1","Filamin-B [OS=Homo sapiens]",14,31,65,20,2602,278,5.73,163.33,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","FLNB","ENSG00000136068","MAPK signaling pathway; Focal adhesion; Salmonella infection; Proteoglycans in cancer","ISG15 antiviral mechanism","Focal adhesion; MAPK signaling pathway; VEGFA-VEGFR2 signaling pathway; Ebola virus pathway in host",1761.1,2046.5,1763.7,1703.7,1659.4,6930.7,0.5412287007713381,-0.8856897489901518,0.41979571566550955,0.37696199803642577,0.6178588171162323,0.20911075137099827,4966]
["O75376-1","Nuclear receptor corepressor 1 [OS=Homo sapiens]",8,21,29,21,2440,270,7.11,79.66,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","NCOR1","ENSG00000141027","Endocrine resistance; Thyroid hormone signaling pathway; Transcriptional misregulation in cancer","HDACs deacetylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Transcriptional activation of mitochondrial biogenesis; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Nuclear Receptor transcription pathway; Cytoprotection by HMOX1; Nuclear signaling by ERBB4; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NR1D1 (REV-ERBA) represses gene expression; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis","Androgen receptor signaling pathway; Adipogenesis; Ovarian infertility; MECP2 and associated Rett syndrome; Pathways affected in adenoid cystic carcinoma; Rett syndrome causing genes; 22q11.2 copy number variation syndrome; Notch signaling pathway (Netpath)",3290.3,3247.7,3430.5,3943.6,3983.5,6022,0.714633919034203,-0.48472370396850495,0.1262091784773596,0.8989090601701685,0.37544276983761554,0.4254562547662764,2457]
["O75379-1","Vesicle-associated membrane protein 4 [OS=Homo sapiens]",32,3,4,3,141,16.4,7.34,8.97,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","VAMP4","ENSCATG00000035773; ENSG00000117533; ENSGGOG00000023200; ENSMFAG00000031870; ENSMLEG00000033096; ENSMMUG00000023203; ENSMNEG00000025169; ENSNLEG00000015204; ENSPANG00000022546; ENSPPAG00000028975; ENSPTRG00000001680; ENSRBIG00000031656; ENSRROG00000036404","SNARE interactions in vesicular transport","Retrograde transport at the Trans-Golgi-Network; Cargo recognition for clathrin-mediated endocytosis","",143,140.1,126.6,160.8,199,176,0.7646509891750655,-0.38712668836207775,0.02616189915132855,1.582330732786423,0.1836861872209994,0.7359235004129863,1041]
["O75380","NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [OS=Homo sapiens]",29,3,4,3,124,13.7,8.28,14.58,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity;other molecular function","NDUFS6","ENSG00000145494","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",102,96.8,79.9,120.1,111.9,121.9,0.78751059621362,-0.34462875932142084,0.02697900788358725,1.5689740249608422,0.18567755990691076,0.7312405798223194,1062]
["O75381-1","Peroxisomal membrane protein PEX14 [OS=Homo sapiens]",41,12,27,12,377,41.2,4.94,82.63,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","PEX14","ENSG00000142655; ENSMFAG00000032533; ENSMMUG00000019979; ENSPANG00000017539; ENSPPAG00000038193; ENSPTRG00000000132","Peroxisome","Peroxisomal protein import; E3 ubiquitin ligases ubiquitinate target proteins; Class I peroxisomal membrane protein import","",2889.9,2876.6,2630.7,3134.3,3222.8,3408.4,0.8598842865188676,-0.21778556355784418,0.017430232986609527,1.7586968077194611,0.152207375028828,0.8175643038287481,837]
["O75385","Serine/threonine-protein kinase ULK1 [OS=Homo sapiens]",2,2,2,2,1050,112.6,8.79,1.95,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","ULK1","ENSG00000177169","Mitophagy; Autophagy; mTOR signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration","RAB GEFs exchange GTP for GDP on RABs; Macroautophagy; TBC/RABGAPs; Receptor Mediated Mitophagy","Target of rapamycin (TOR) signaling; Alzheimer's disease and miRNA effects; Nanoparticle triggered autophagic cell death; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; 7q11.23 copy number variation syndrome; p53 transcriptional gene network; Malignant pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; Senescence and autophagy in cancer",300.1,301.3,300,242.8,233.8,384.4,1.0469221835075495,0.0661542124311528,0.7961347621359203,0.09901341279208094,0.8712305699133764,0.059866894372842296,6679]
["O75386","Tubby-related protein 3 [OS=Homo sapiens]",2,1,2,1,442,49.6,7.74,4.86,"developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","TULP3","ENSG00000078246","","Hedgehog 'off' state","H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Genes related to primary cilium development (based on CRISPR)",243.5,278.6,276.9,268.5,277.5,169.8,1.1162335848002234,0.15863895939895475,0.4879078629515651,0.31166218289416975,0.659415416108171,0.18084090394377633,5408]
["O75390","citrate synthase, mitochondrial [OS=Homo sapiens]",41,17,151,17,466,51.7,8.32,428.26,"other metabolic processes","mitochondrion","other molecular function","CS","ENSG00000062485","Citrate cycle (TCA cycle); Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids","Citric acid cycle (TCA cycle); Mitochondrial protein import","TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Fluoroacetic acid toxicity; TCA cycle (aka Krebs or citric acid cycle)",20963.7,20520.4,19937.6,19051.1,18924.2,21812.9,1.0273214446997903,0.03888766570140061,0.6109564519474466,0.21398974450857364,0.7458628206587419,0.12734104077028552,5987]
["O75396","Vesicle-trafficking protein SEC22b [OS=Homo sapiens]",38,7,51,7,215,24.6,6.92,195.73,"","","","","","","","",4833.3,4881.8,4660.1,4298,4549.9,4692.3,1.0616682176038759,0.08633297932191346,0.10540071053515876,0.977156461415137,0.3460798712046161,0.46082365952985355,2226]
["O75398","Deformed epidermal autoregulatory factor 1 homolog [OS=Homo sapiens]",1,1,1,1,565,59.3,5.34,2.35,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;nucleus;other cell component","nucleic acid binding activity;other molecular function","DEAF1","ENSG00000177030","","","Sudden infant death syndrome (SIDS) susceptibility pathways",62.2,66.5,68.8,75.4,76.4,45.1,1.0030472320975112,0.004389542050273659,0.985648761905692,0.006277819279967626,0.9920279262969847,3.4761019728681668E-3,7262]
["O75400","pre-mRNA-processing factor 40 homolog A [OS=Homo sapiens]",30,24,56,1,957,108.7,7.56,145.1,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","","PRPF40A","ENSG00000196504","Spliceosome","mRNA Splicing - Major Pathway","mRNA processing",98.8,100.1,90.4,106.6,107.9,152,0.7893587994542973,-0.3412468750915748,0.16631613919754676,0.7790656051139517,0.4237032629469743,0.3729381914759771,2869]
["O75400-3","Isoform 3 of Pre-mRNA-processing factor 40 homolog A [OS=Homo sapiens]",29,24,60,1,939,106.8,7.43,150.08,"","","","PRPF40A","","","","",7946.5,8351.1,8521.7,8218.2,7747.9,4604.7,1.2065306162132732,0.2708645250013568,0.2845333521590647,0.5458668195687914,0.5357172258966008,0.27106438873716243,3882]
["O75410-1","Transforming acidic coiled-coil-containing protein 1 [OS=Homo sapiens]",52,30,97,27,805,87.7,4.88,317.53,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","TACC1","ENSG00000147526","","","",9311.1,9355.6,9692.8,9714.8,10183.4,9163,0.9758544038098909,-0.035262179240924424,0.5035220258013343,0.2979815271465939,0.6704759494592736,0.17361679604423588,5489]
["O75414","Nucleoside diphosphate kinase 6 [OS=Homo sapiens]",17,3,7,3,186,21.1,8.32,21.18,"other metabolic processes;other biological processes","mitochondrion","kinase activity;other molecular function","NME6","ENSG00000172113","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors","","Pyrimidine metabolism",587.5,586.7,594.9,571.2,530.7,2026,0.5655871351385913,-0.822178789950161,0.40920926736773755,0.38805453937557793,0.6123895444698595,0.21297223276444982,4884]
["O75419","Cell division control protein 45 homolog [OS=Homo sapiens]",3,2,2,2,566,65.5,5.53,4.77,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","CDC45","ENSG00000093009","Cell cycle","Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA; G1/S-Specific Transcription","Cell cycle; Retinoblastoma gene in cancer; G1 to S cell cycle control; 22q11.2 copy number variation syndrome; DNA replication",171.8,180.1,195.5,218.6,205.9,347.2,0.7093430089412984,-0.49544467104310624,0.17690064217524853,0.7522705905348182,0.4351958241867693,0.3613152804545093,2971]
["O75420","GRB10-interacting GYF protein 1 [OS=Homo sapiens]",8,6,8,6,1035,114.5,5.39,22.65,"signal transduction","cytosol;other cell component","","GIGYF1","ENSG00000146830","","","",333.7,323.6,331,366.4,385.5,676.8,0.6917477427031568,-0.5316820638168958,0.21781575513649296,0.6619107098815659,0.47851378247448967,0.32010554886641535,3327]
["O75427","Leucine-rich repeat and calponin homology domain-containing protein 4 [OS=Homo sapiens]",29,13,29,13,683,73.4,8.22,97.56,"developmental processes","nucleus","","LRCH4","ENSG00000077454","","","",1784.5,1627.3,1665.3,1491.8,1598.6,1369.7,1.1383377054326138,0.186928618872251,0.06475665874242373,1.188715567688327,0.27485854747292393,0.56089075292199,1722]
["O75431","Metaxin-2 [OS=Homo sapiens]",39,7,29,7,263,29.7,6.29,115.23,"cell organization and biogenesis;transport","other membranes;mitochondrion;nucleus;other cell component","","MTX2","ENSG00000128654","","Mitochondrial protein import; Cristae formation","",1527.7,1646.1,1473.6,1666.1,1478.8,2193.3,0.8705930838110224,-0.1999295358127471,0.3540922461809695,0.45088358320429506,0.5856664918164078,0.23234962288261546,4419]
["O75436-1","Vacuolar protein sorting-associated protein 26A [OS=Homo sapiens]",51,14,42,12,327,38.1,6.57,115.45,"transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","VPS26A","ENSANAG00000022406; ENSCATG00000037809; ENSCCAG00000021117; ENSCJAG00000012907; ENSCSAG00000007798; ENSG00000122958; ENSMFAG00000042937; ENSMMUG00000004101; ENSMNEG00000039163; ENSNLEG00000011548; ENSPANG00000022152; ENSPPAG00000041182; ENSPPYG00000002386; ENSPTRG00000002567; ENSRBIG00000023684; ENSRROG00000006745; ENSSBOG00000030031","Endocytosis","WNT ligand biogenesis and trafficking","",3880.6,4707.4,4607.1,3823.6,3271.8,3597.8,1.233971121834437,0.30330863202886355,0.052594814834055065,1.2790570695336658,0.2501076783488019,0.601872975149438,1537]
["O75438","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [OS=Homo sapiens]",19,1,3,1,58,7,8.92,7.18,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB1","ENSG00000183648","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",230,269.8,438.9,266.8,521.1,816.7,0.5850056088744859,-0.7734776379577916,0.26479361984898153,0.5770924833477549,0.5212433524040415,0.2829594706899408,3713]
["O75439","mitochondrial-processing peptidase subunit beta [OS=Homo sapiens]",42,17,69,16,489,54.3,6.83,218.05,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport","other membranes;mitochondrion","other molecular function","PMPCB","ENSG00000105819","","Mitochondrial protein import; Processing of SMDT1","",6787.7,7212.6,6942.8,6338.3,5830.4,6872,1.099912293140483,0.1373884880262484,0.12307037424034807,0.9098464787698751,0.3704783217968303,0.4312371992891222,2428]
["O75448","Mediator of RNA polymerase II transcription subunit 24 [OS=Homo sapiens]",14,10,14,10,989,110.2,6.95,41.37,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","MED24","ENSG00000008838","Thyroid hormone signaling pathway","Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","",979.2,904.6,949.3,891.1,956.1,840,1.054294432866925,0.07627782477184421,0.2906968049884471,0.5365597414786688,0.5404993507149732,0.26720482341478496,3931]
["O75449-1","Katanin p60 ATPase-containing subunit A1 [OS=Homo sapiens]",15,8,11,7,491,55.9,6.9,16.05,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KATNA1","ENSG00000186625","","","",1322.3,1475.6,1299.7,1414.4,1283.5,1140.5,1.0675281367236347,0.09427409530403365,0.42113599579611255,0.3755776365006242,0.6182130936480792,0.20886180089211082,4979]
["O75460","Serine/threonine-protein kinase/endoribonuclease IRE1 [OS=Homo sapiens]",22,15,31,15,977,109.7,6.42,111.1,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","ERN1","ENSG00000178607","Autophagy; Protein processing in endoplasmic reticulum; Apoptosis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Lipid and atherosclerosis","IRE1alpha activates chaperones","Alzheimer's disease and miRNA effects; Corticotropin-releasing hormone signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling pathway; Nonalcoholic fatty liver disease; Unfolded protein response; Alzheimer's disease",2374.9,2440.5,2345.5,2940.8,3198.4,4318.1,0.6847752287875455,-0.546297580577832,0.06046642758338255,1.2184856891856017,0.26448181879529803,0.5776041771950201,1671]
["O75475-1","PC4 and SFRS1-interacting protein [OS=Homo sapiens]",51,28,82,27,530,60.1,9.13,247.61,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PSIP1","ENSG00000164985; ENSGGOG00000016152; ENSPTRG00000020786","","Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection","MECP2 and associated Rett syndrome",11327.8,11208.1,10998.1,11971.4,12573.7,10714.8,0.9510520449575866,-0.07240380222663775,0.3592555609515642,0.4445965006554301,0.5879531784583482,0.23065725750687627,4466]
["O75477","erlin-1 [OS=Homo sapiens]",27,10,23,7,346,38.9,7.87,65.26,"","","","","","","","",1701.6,1792.3,1714,1796.5,1707.4,2433.8,0.8770904559004327,-0.18920245683607814,0.35075606705966333,0.45499480820339416,0.5827861091473242,0.2344908082962842,4399]
["O75487","Glypican-4 [OS=Homo sapiens]",10,4,7,4,556,62.4,6.68,26.89,"cell adhesion;cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes","extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","GPC4","ENSG00000076716","Wnt signaling pathway","A tetrasaccharide linker sequence is required for GAG synthesis; HS-GAG biosynthesis; HS-GAG degradation; Defective B4GALT7 causes EDS, progeroid type; Defective B3GAT3 causes JDSSDHD; Defective EXT2 causes exostoses 2; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Defective B3GALT6 causes EDSP2 and SEMDJL1; Retinoid metabolism and transport","Wnt signaling",762.3,664.3,670.4,775.3,921.1,793.6,0.8421686746987952,-0.24781888085885068,0.07851741803570472,1.105033990163252,0.3044476437257113,0.5164873828210907,1885]
["O75489","NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [OS=Homo sapiens]",63,16,72,16,264,30.2,7.5,211.44,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion;nucleus","transporter activity;other molecular function","NDUFS3","ENSG00000213619; ENSG00000285387","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","RHOG GTPase cycle; Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",8233.1,7915.7,7730.9,8658.4,8690.6,6648.9,0.9950745690247895,-7.1234523152651705E-3,0.9572650950960897,0.01896777654439409,0.9732439254496202,0.011778298271956141,7189]
["O75494-1","Serine/arginine-rich splicing factor 10 [OS=Homo sapiens]",30,10,43,10,262,31.3,11.27,118.09,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","Srsf10; SRSF10","ENSCATG00000031598; ENSCCAG00000022497; ENSCPOG00000034102; ENSG00000188529; ENSGGOG00000000392; ENSMLEG00000016013; ENSMNEG00000041500; ENSMUSG00000028676; ENSNLEG00000027520; ENSPANG00000021680; ENSPCOG00000022379; ENSPCTG00005007467; ENSPPAG00000032557; ENSPPYG00000001726; ENSPTRG00000044753; ENSRBIG00000028456; ENSRFEG00010001865; ENSRROG00000043248; ENSSBOG00000019550; ENSSSCG00070027414; ENSSTOG00000000956; ENSTSYG00000009439","Spliceosome","mRNA Splicing - Major Pathway; mRNA Splicing - Major Pathway","mRNA processing; mRNA processing; mRNA Processing",6648.8,6122.6,6200.5,6696.7,7399.6,7740.8,0.8687921015153113,-0.20291710771710578,0.051825500406097784,1.2854564958417662,0.24822580764624422,0.6051530675766549,1526]
["O75503","Ceroid-lipofuscinosis neuronal protein 5 [OS=Homo sapiens]",13,3,4,3,358,41.5,7.4,11.35,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CLN5","ENSG00000102805","Lysosome","","",110,108.6,95.7,90.4,99.1,128.5,0.9883647798742138,-0.016884493372966738,0.9255142115672946,0.03361690812893936,0.951418195829164,0.021628546974732737,7110]
["O75521","Enoyl-CoA delta isomerase 2, mitochondrial [OS=Homo sapiens]",48,13,45,13,394,43.6,9,154.73,"other metabolic processes","cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","ECI2","ENSG00000198721","Fatty acid degradation; Peroxisome","","",3750.1,3843.6,3803.8,3618.1,3693.1,3085.9,1.0962191380288733,0.13253622689856853,0.15915773936849717,0.7981722380777964,0.41575551002299704,0.3811619863496323,2798]
["O75525-1","KH domain-containing, RNA-binding, signal transduction-associated protein 3 [OS=Homo sapiens]",9,4,17,2,346,38.8,7.61,34.39,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KHDRBS3","ENSCCAG00000031191; ENSG00000131773; ENSGGOG00000000940; ENSRBIG00000036854; ENSRROG00000044792","","PTK6 Regulates Proteins Involved in RNA Processing","",105.3,99.4,106.1,126.9,130.9,228.7,0.6388489208633092,-0.6464533012607642,0.1539467783618244,0.8126293951292282,0.40975855901186253,0.38747196614599155,2746]
["O75530","Polycomb protein EED [OS=Homo sapiens]",20,7,11,7,441,50.2,7.03,34.57,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","EED","ENSG00000074266","","Transcriptional Regulation by E2F6; HCMV Early Events; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; PKMTs methylate histone lysines; PRC2 methylates histones and DNA; Defective pyroptosis","Histone modifications; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Malignant pleural mesothelioma",1035.8,1135.6,1040,1224,1058,1029.6,0.9697427225510327,-0.04432605081686461,0.6528656323795625,0.18517619256992432,0.7771652943098082,0.10948660182711906,6140]
["O75531","Barrier-to-autointegration factor [OS=Homo sapiens]",30,3,4,3,89,10.1,6.09,5.01,"cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","BANF1","ENSG00000175334","","Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Nuclear Envelope Breakdown; Initiation of Nuclear Envelope (NE) Reformation","Envelope proteins and their potential roles in EDMD physiopathology; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy",237.8,207.6,277.1,227.2,247.3,164.6,1.1304960100140824,0.17695590023357752,0.4341959287452817,0.3623142530413132,0.6249582597871729,0.2041489876950436,5078]
["O75533-1","splicing factor 3B subunit 1 [OS=Homo sapiens]",49,53,229,53,1304,145.7,7.09,699.58,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","LOC101357717; LOC111145177; Sf3b1; SF3B1","ENSANAG00000021577; ENSCANG00000029415; ENSCATG00000035735; ENSCCAG00000020506; ENSCGRG00001016990; ENSCGRG00015028775; ENSCJAG00000003902; ENSCSAG00000011505; ENSDLEG00000016863; ENSFCAG00000005038; ENSG00000115524; ENSLAFG00000001956; ENSLCNG00005009987; ENSMMNG00015005194; ENSMMUG00000022430; ENSMNEG00000042333; ENSMPUG00000007799; ENSMUSG00000025982; ENSNLEG00000006861; ENSPANG00000013417; ENSPCTG00005000567; ENSPPAG00000035007; ENSRNOG00000013516; ENSRROG00000031308; ENSSBOG00000020080; ENSSSCG00000016075; ENSSSCG00070023758; ENSSSUG00005005995; ENSSTOG00000011034; ENSUMAG00000020945","Spliceosome","B-WICH complex positively regulates rRNA expression; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; mRNA Splicing - Major Pathway; B-WICH complex positively regulates rRNA expression; mRNA Splicing - Minor Pathway; mRNA Splicing - Major Pathway; B-WICH complex positively regulates rRNA expression; mRNA Splicing - Minor Pathway","mRNA processing; mRNA processing; mRNA processing",26298.9,26919.2,26229.9,30282.9,29921.9,30516.4,0.8757379752472408,-0.1914288213607675,1.7626528718148459E-4,3.7538332070988116,0.023005767571597693,1.638163272221039,56]
["O75534","cold shock domain-containing protein E1 [OS=Homo sapiens]",39,32,122,32,798,88.8,6.25,346.46,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","nucleic acid binding activity","CSDE1","ENSG00000009307","","","",17747.2,17976.1,18361.7,22128.8,21274.5,18451.9,0.8743808119608375,-0.19366635306405447,0.08279523884660457,1.081994636670421,0.3127392251833761,0.5048176441413782,1935]
["O75554","WW domain-binding protein 4 [OS=Homo sapiens]",5,2,2,2,376,42.5,5.57,5.48,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","WBP4","ENSG00000120688","","mRNA Splicing - Major Pathway","",325,307.9,294.1,347.1,344.6,448.2,0.8132292306342661,-0.2982660226791446,0.11456325300026117,0.9409546631576814,0.3609236276633228,0.44258468616460805,2320]
["O75558","syntaxin-11 [OS=Homo sapiens]",5,1,4,1,287,33.2,6.55,17.41,"cell-cell signaling;cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","STX11","ENSG00000135604","SNARE interactions in vesicular transport","","",250.1,225.9,237.4,201.2,219,241.1,1.0787842129139573,0.1094063142302806,0.26745334370594265,0.5727519681785266,0.5225384894805493,0.2818817144927586,3741]
["O75569-1","Interferon-inducible double-stranded RNA-dependent protein kinase activator A [OS=Homo sapiens]",29,8,30,8,313,34.4,8.41,86.74,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;kinase activity;other molecular function","PRKRA","ENSCATG00000032736; ENSG00000180228; ENSMNEG00000031681; ENSPANG00000001046; ENSPTRG00000012688","","MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis","VEGFA-VEGFR2 signaling pathway; Ebola virus pathway in host",3780.2,3712.7,3721.2,3353.5,3310.7,3951.7,1.0563494381069904,0.07908715404472497,0.3919970157359744,0.4067172392405944,0.6027995346127155,0.21982709165137995,4753]
["O75570","Peptide chain release factor 1, mitochondrial [OS=Homo sapiens]",6,2,3,2,445,52.3,8.5,7.44,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","mitochondrion","nucleic acid binding activity","MTRF1","ENSG00000120662","","","",226.2,168.6,216.3,159,187.2,79.5,1.435517970401691,0.5215713909053362,0.16858452488234069,0.7731822936890987,0.4254780015072611,0.371122889330235,2896]
["O75582-1","Ribosomal protein S6 kinase alpha-5 [OS=Homo sapiens]",3,2,2,2,802,89.8,7.11,4.81,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","kinase activity;other molecular function","RPS6KA5","ENSG00000100784; ENSGGOG00000004254; ENSPPAG00000038077; ENSPTRG00000006631","MAPK signaling pathway; Adrenergic signaling in cardiomyocytes; TNF signaling pathway; Circadian entrainment; Neurotrophin signaling pathway; Shigellosis; Pathways in cancer; MicroRNAs in cancer; Bladder cancer","Recycling pathway of L1; NCAM signaling for neurite out-growth; ERK/MAPK targets; CREB phosphorylation; CD209 (DC-SIGN) signaling","Brain-derived neurotrophic factor (BDNF) signaling pathway; Interleukin-1 (IL-1) structural pathway; Bladder cancer; MAPK signaling pathway; ERK pathway in Huntington's disease; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; p38 MAPK signaling pathway; EGF/EGFR signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Insulin signaling; Malignant pleural mesothelioma; Interferon type I signaling pathways; Serotonin receptor 4/6/7 and NR3C signaling; EGFR1 signaling pathway; MAPK signaling pathway; p38 MAPK signaling pathway",104.2,72.8,92.2,96.9,107.3,78.4,0.9525831564048124,-0.07008305572362239,0.7379878456644875,0.13195079075732677,0.8315019522062185,0.08013672680358049,6487]
["O75586","Mediator of RNA polymerase II transcription subunit 6 [OS=Homo sapiens]",13,4,4,4,246,28.4,8.62,8.85,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MED6","ENSG00000133997","","Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","",715,710,716.7,761.2,780.3,433.3,1.0845148875835529,0.11704985761649538,0.6472556944919683,0.1889241199961262,0.7727526741329298,0.11195948337346907,6122]
["O75592-1","E3 ubiquitin-protein ligase MYCBP2 [OS=Homo sapiens]",18,71,138,1,4640,509.8,7.03,376.42,"","","","","","","","",103.5,117.4,107.2,92.7,85.7,60.1,1.3756813417190776,0.46014632762554597,0.04983508721308759,1.3024647773723472,0.2438049882466246,0.6129574129677543,1494]
["O75592-2","Isoform 2 of E3 ubiquitin-protein ligase MYCBP2 [OS=Homo sapiens]",18,71,138,1,4637,509.4,7.03,374.77,"","","","","","","","",14254.7,14496.7,14287.7,14164.2,14023.6,17951.4,0.9328098449908104,-0.10034507988618736,0.4675624357326428,0.3301603876071804,0.6462582909927924,0.18959387220079127,5288]
["O75607","Nucleoplasmin-3 [OS=Homo sapiens]",44,5,34,5,178,19.3,4.63,111.29,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","NPM3","ENSG00000107833","","","",2391.2,2684.1,2375,2851.6,2587.8,2784.3,0.9059547405668978,-0.1424891165702354,0.11400836470910915,0.943063283630724,0.359640542796236,0.44413135553672656,2317]
["O75608","Acyl-protein thioesterase 1 [OS=Homo sapiens]",49,8,37,8,230,24.7,6.77,117.04,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","LYPLA1","ENSG00000120992","Glycerophospholipid metabolism; Choline metabolism in cancer","RAS processing; eNOS activation","",4994.7,4424.4,4820.8,4325.1,4437.5,4005.5,1.1152716535741414,0.15739515905142396,0.08230354395171426,1.0845814638699136,0.31233468470564874,0.5053797847744564,1926]
["O75616-1","GTPase Era, mitochondrial [OS=Homo sapiens]",24,7,15,7,437,48.3,8.84,51.11,"cell organization and biogenesis","other membranes;cytosol;mitochondrion","translation activity;nucleic acid binding activity;other molecular function","ERAL1","ENSG00000132591","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Integrated breast cancer pathway",1298.4,1299.6,1285.2,1177.6,1257.3,1558,0.9725262340654662,-0.04019092731226441,0.7681876538382358,0.11453267701074643,0.8513545961946423,0.06988951500915758,6595]
["O75626-1","PR domain zinc finger protein 1 [OS=Homo sapiens]",5,4,9,3,825,91.7,8.48,18.45,"cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","PRDM1","ENSG00000057657","","STAT3 nuclear events downstream of ALK signaling; Regulation of TP53 Expression","Nucleotide-binding oligomerization domain (NOD) pathway; Vitamin D receptor pathway; IL-6 signaling pathway; Overview of leukocyte-intrinsic Hippo pathway functions",272,314.7,274.7,561.4,636.4,576.9,0.4853778103341411,-1.0428199395351887,3.377121812819551E-4,3.4714532740755017,0.027425981477664552,1.561837821630854,90]
["O75643-1","U5 small nuclear ribonucleoprotein 200 kDa helicase [OS=Homo sapiens]",42,80,293,79,2136,244.4,6.06,888.7,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","SNRNP200","ENSCATG00000015790; ENSG00000144028; ENSGGOG00000005174; ENSMLEG00000019083; ENSPPAG00000041559; ENSPPYG00000012068; ENSPTRG00000012230; ENSRBIG00000044690; ENSRROG00000037952","Spliceosome","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","",34977.9,34808.1,35746.8,35500,35005.1,29160.1,1.0588731071627808,0.0825297105429601,0.3953678209471919,0.402998680884191,0.6040433535332412,0.21893188998057242,4784]
["O75648-1","Mitochondrial tRNA-specific 2-thiouridylase 1 [OS=Homo sapiens]",33,12,22,12,421,47.7,8.03,61.55,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","nucleic acid binding activity;other molecular function","TRMU","ENSG00000100416","","tRNA modification in the mitochondrion","",1773.1,1763.3,1787.1,1629.2,1459.8,1880,1.0713423223988732,0.09941953323199111,0.3884914672568681,0.4106185155090212,0.6012035007792609,0.22097849920174817,4723]
["O75663","TIP41-like protein [OS=Homo sapiens]",33,9,38,9,272,31.4,5.91,107.7,"stress response;signal transduction;other biological processes","cytosol","","TIPRL","ENSG00000143155","","","Ciliary landscape",5216.2,5532.6,5070.8,5484.6,5165.1,4674,1.0323616358973353,0.04594843483486199,0.5766141813962453,0.2391146806672047,0.7205459141434702,0.14233834014655394,5849]
["O75665","Oral-facial-digital syndrome 1 protein [OS=Homo sapiens]",4,4,4,4,1012,116.6,6.1,14.19,"cell organization and biogenesis;transport;developmental processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","OFD1","ENSG00000046651","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Hedgehog 'off' state","Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies",286.5,352,337.2,387.9,309.6,310.8,0.9676683526728158,-0.04741541509079658,0.7557867334996332,0.12160073562417793,0.8432369462904624,0.07405037317214476,6551]
["O75674","TOM1-like protein 1 [OS=Homo sapiens]",5,1,2,1,476,53,5.24,10.18,"protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","TOM1L1","ENSG00000141198","","","",48.5,51.2,47.7,43.3,65.3,97.7,0.7144934561318468,-0.4850072967914151,0.28278351201443985,0.548545916126541,0.5347644733023392,0.2718374524969117,3865]
["O75676","Ribosomal protein S6 kinase alpha-4 [OS=Homo sapiens]",9,7,8,7,772,85.6,8.28,21.95,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","RPS6KA4","ENSG00000162302","MAPK signaling pathway; TNF signaling pathway","Recycling pathway of L1","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Translation inhibitors in chronically activated PDGFRA cells; Insulin signaling; Interferon type I signaling pathways",747.9,639.8,662.8,628.6,711.3,819,0.9497892445226735,-0.07432067577434853,0.6035045402302078,0.21931945830978228,0.7410978972685801,0.13012441896363164,5952]
["O75683","Surfeit locus protein 6 [OS=Homo sapiens]",17,3,6,3,361,41.4,10.64,16.61,"other biological processes","nucleus;other cell component","nucleic acid binding activity","SURF6","ENSG00000148296; ENSG00000281309","","","",57.5,63.2,56.4,107.4,111.5,148,0.4826928318342873,-1.0508226924966286,0.008408458385440513,2.0752836208569487,0.10974539703425841,0.9596136859791761,560]
["O75688","Protein phosphatase 1B [OS=Homo sapiens]",30,12,32,1,479,52.6,5.05,85.91,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;nucleus","other molecular function","PPM1B","ENSG00000138032","MAPK signaling pathway","ISG15 antiviral mechanism; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants","MAPK signaling pathway",2835.9,2946,2838.4,2757.5,2841.6,2556.3,1.0570051744856168,0.07998243933787681,0.16771483882692836,0.7754285108253125,0.4247497425453983,0.37186687569881494,2886]
["O75688-2","Isoform Beta-2 of Protein phosphatase 1B [OS=Homo sapiens]",36,12,32,1,387,42.7,5.2,78.89,"","","","PPM1B","","","","",201.7,208,166.8,193.8,197.4,280.3,0.8585256887565151,-0.22006679177567068,0.365074091288808,0.4376189871257665,0.58942490241438,0.2295715197370458,4527]
["O75691","Small subunit processome component 20 homolog [OS=Homo sapiens]",11,23,31,23,2785,318.2,7.39,92.85,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;nucleus;other cell component","","UTP20","ENSG00000120800","","rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol","",2851.6,2884.8,2882.5,5034.3,5337.5,4439.7,0.5819059514566384,-0.7811420935256216,1.442138415784102E-3,2.840993054230784,0.05244074468142289,1.2803311497672998,201]
["O75694","nuclear pore complex protein nup155 [OS=Homo sapiens]",25,26,67,26,1391,155.1,6.16,198.87,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;nucleus","other molecular function","NUP155","ENSG00000113569","Nucleocytoplasmic transport; Amyotrophic lateral sclerosis","HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation","",5876.5,6257.9,6196.9,5660,5298.9,4918.9,1.1545239264885565,0.20729807200219696,0.02869661063070845,1.5421693949491224,0.1892992121839784,0.7228511934575603,1108]
["O75695","Protein XRP2 [OS=Homo sapiens]",31,9,25,9,350,39.6,5.12,60.43,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","enzyme regulator activity;other molecular function","RP2","ENSG00000102218","","Trafficking of myristoylated proteins to the cilium","Joubert syndrome; Ciliopathies",2930.2,2719.4,2704.7,2028.4,2125.4,2211,{"$f":"AVERAGE(S642:U642)/AVERAGE(V642:X642)","v":1.312578557063851},{"$f":"LOG(Y642,2)","v":0.39240376982248865},{"$f":"TTEST(V642:X642,S642:U642,2,2)","v":1.8025074752494605E-3},2.744122925525116,{"$f":"AA642*7309/AE642","v":0.055588722095351505},1.255013309651247,237]
["O75717","WD repeat and HMG-box DNA-binding protein 1 [OS=Homo sapiens]",16,12,13,12,1129,125.9,5.62,27.54,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response","nucleus;other cell component","nucleic acid binding activity;other molecular function","WDHD1","ENSG00000198554","","","Mesodermal commitment pathway",1136.1,1123.4,1237.6,1235.9,1365.9,1920.1,0.7733696012738009,-0.3707700371558689,0.18382677381759052,{"$f":"-LOG10(AA643)","v":0.7355912346559652},0.44138958273087026,{"$f":"-LOG10(AC643)","v":0.3551779208705275},3044]
["O75718","Cartilage-associated protein [OS=Homo sapiens]",17,6,7,6,401,46.5,5.73,22.1,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;ER/Golgi;other cell component","","CRTAP","ENSG00000170275","","Collagen biosynthesis and modifying enzymes","Type I collagen synthesis in the context of osteogenesis imperfecta",417.3,408.9,416.1,425.9,421.3,758.5,0.7736812605094353,-0.37018876442478216,0.33904886880228335,0.46973770025834993,0.5761702353117621,0.2394491809284688,4301]
["O75746","Calcium-binding mitochondrial carrier protein Aralar1 [OS=Homo sapiens]",27,17,28,12,678,74.7,8.38,83.01,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","SLC25A12","ENSG00000115840","","Mitochondrial protein import; Gluconeogenesis; Aspartate and asparagine metabolism","",3868.2,3953.7,3911.2,3441.1,3498,5925.1,0.9120738172603037,-0.13277750351738815,0.6691929761363388,0.17444862604980796,0.7869881677522929,0.10403179714349856,6215]
["O75787","Renin receptor [OS=Homo sapiens]",12,3,6,3,350,39,6.1,20.4,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ATP6AP2","ENSG00000182220","Renin-angiotensin system","Neutrophil degranulation; Metabolism of Angiotensinogen to Angiotensins","ACE inhibitor pathway; Oxidative phosphorylation",239.4,278.7,228.1,217.2,219.8,699.8,0.6564039408866995,-0.6073441944260004,0.46447255813445265,0.3330399398034661,0.6434476738826221,0.19148676479382082,5276]
["O75792","Ribonuclease H2 subunit A [OS=Homo sapiens]",25,7,14,7,299,33.4,5.25,47.15,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RNASEH2A","ENSG00000104889","DNA replication","","",1139.4,1217.4,1104.7,1261.8,1300.3,1489,0.8544592826639679,-0.22691634973653302,0.06472925881859368,1.1888993658360438,0.2750617166890123,0.5605698508596199,1720]
["O75794","Cell division cycle protein 123 homolog [OS=Homo sapiens]",24,6,16,6,336,39.1,4.81,41.87,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","other cell component","","CDC123","ENSG00000151465","","","",866.4,842.2,845.5,1634.7,1621,1726.7,0.5126244380218369,-0.964025837926782,1.8548291505954235E-5,4.731696087326991,0.015063273624113277,1.8220806348823433,9]
["O75795","UDP-glucuronosyltransferase 2B17 [OS=Homo sapiens]",11,6,14,6,530,61.1,8.54,31.24,"other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","UGT2B17","ENSG00000197888","Pentose and glucuronate interconversions; Ascorbate and aldarate metabolism; Steroid hormone biosynthesis; Retinol metabolism; Porphyrin and chlorophyll metabolism; Metabolism of xenobiotics by cytochrome P450; Drug metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors; Bile secretion; Chemical carcinogenesis; Chemical carcinogenesis","Glucuronidation","Glucuronidation; Metapathway biotransformation Phase I and II",1112.1,1066.7,1061.3,1013,962.9,3682.9,0.5725772248533259,-0.8044578088404116,0.4203159878784647,0.3764240900913122,0.6177537815008443,0.2091845874395642,4973]
["O75808-1","Calpain-15 [OS=Homo sapiens]",5,3,3,3,1086,117.2,6.71,12.14,"protein metabolism","other cell component","other molecular function","CAPN15","ENSG00000103326","","Degradation of the extracellular matrix","",106.1,117.2,114.3,138.4,142.6,210.4,0.6870166870166872,-0.5415829536549794,0.09523838726006992,1.0211879674248916,0.3311595492311375,0.47996271723314204,2102]
["O75817","Ribonuclease P protein subunit p20 [OS=Homo sapiens]",11,1,3,1,140,15.6,8.94,12.21,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POP7","ENSG00000172336","Ribosome biogenesis in eukaryotes","tRNA processing in the nucleus","",242.7,248.1,271.6,335.9,323.8,584.1,0.6129602830036982,-0.7061344979206293,0.13304377197307896,0.8760054507708582,0.38420265877172427,0.4154396340451395,2531]
["O75818-1","Ribonuclease P protein subunit p40 [OS=Homo sapiens]",8,2,3,2,363,41.8,6.67,14.23,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RPP40","ENSG00000124787","Ribosome biogenesis in eukaryotes","tRNA processing in the nucleus; Major pathway of rRNA processing in the nucleolus and cytosol","",443.1,467.7,465.7,446.8,487,501,0.9593671591859493,-0.059845040474600986,0.3424326661163547,0.4654248128109157,0.5778897152261456,0.23815503465678503,4331]
["O75820-1","Zinc finger protein 189 [OS=Homo sapiens]",7,3,6,1,626,72.9,8.5,8.26,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF189","ENSG00000136870; ENSGGOG00000003650; ENSPPAG00000034345; ENSPPYG00000019452; ENSPTRG00000021200","Herpes simplex virus 1 infection","Generic Transcription Pathway","",15.7,19.6,19.3,18.5,15.2,19.3,1.030188679245283,0.042908591469290915,0.7785790596141232,0.10869728109092722,0.8592230630710594,0.06589407425384242,6623]
["O75821","Eukaryotic translation initiation factor 3 subunit G [OS=Homo sapiens]",57,20,77,20,320,35.6,6.13,246.58,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity","EIF3G","ENSG00000130811","","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell",9166.7,9243.2,8822.4,10523.9,10441.8,9435.6,0.8957610365346221,-0.1588141811170733,0.047268994872371926,1.3254236324342035,0.23696096263523075,0.6253231945321864,1458]
["O75822","Eukaryotic translation initiation factor 3 subunit J [OS=Homo sapiens]",32,9,27,9,258,29,4.83,70.19,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF3J","ENSG00000104131","","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit","Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell",3575.9,3264.9,2629.4,4235.1,2742.7,1239.7,1.1524429571037422,0.20469534281060378,0.6696424782175627,0.17415700502919662,0.7871368403493352,0.10394976085239666,6218]
["O75828","Carbonyl reductase [NADPH] 3 [OS=Homo sapiens]",43,10,31,6,277,30.8,6.18,97.68,"other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","CBR3","ENSG00000159231","Arachidonic acid metabolism; Metabolism of xenobiotics by cytochrome P450; Metabolic pathways","Phase I - Functionalization of compounds","Nuclear receptors meta-pathway; NRF2 pathway",1139,1067.4,1106.7,986.2,1054.3,967.3,1.1015027594919875,0.1394731092924674,0.03870497999206626,1.4122331527089789,0.2166115610735163,0.664318367764061,1306]
["O75832","26S proteasome non-ATPase regulatory subunit 10 [OS=Homo sapiens]",54,9,38,9,226,24.4,6.1,130.27,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","PSMD10","ENSG00000101843","","Degradation of DVL; Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Parkin-ubiquitin proteasomal system pathway",3431.4,3760.8,3876.3,3896.7,3581.6,7583.3,0.7348820842407182,-0.4444153145009154,0.3609608070468935,0.44253995102318316,0.5877172062164724,0.23083159454086308,4489]
["O75843","AP-1 complex subunit gamma-like 2 [OS=Homo sapiens]",5,4,6,4,785,87.1,6.55,14.17,"transport","other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","AP1G2","ENSG00000213983","Lysosome; Human immunodeficiency virus 1 infection","Lysosome Vesicle Biogenesis","",506.5,532.6,477.7,534.2,524.9,860.7,0.7900823002396083,-0.3399251530365306,0.2948736634790466,0.5303640145505718,0.5443878773347692,0.2640915544188035,3959]
["O75844","caax prenyl protease 1 homolog [OS=Homo sapiens]",31,14,57,14,475,54.8,7.49,155.37,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZMPSTE24","ENSG00000084073","Terpenoid backbone biosynthesis","","Adipogenesis; Lamin A-processing pathway; Nephrotic syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy",7704.8,6920.3,6859.6,5900.9,6486.7,3979.5,1.3126760391272736,0.3925109113467766,0.10134260245060535,0.9942079473373824,0.3405577385340113,0.46780924674406554,2175]
["O75865-1","Trafficking protein particle complex subunit 6A [OS=Homo sapiens]",6,1,1,1,159,17.6,5.26,2.3,"cell organization and biogenesis;transport;other biological processes","cytosol;ER/Golgi;other cell component","","TRAPPC6A","ENSG00000007255","","RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport","",35.9,37.4,31.2,32.7,26.5,20.4,1.312814070351759,0.39266260642459655,0.10737221208590834,0.9691080994487083,0.3475569079432702,0.4589740751536844,2258]
["O75874","Isocitrate dehydrogenase [NADP] cytoplasmic [OS=Homo sapiens]",52,22,138,21,414,46.6,7.01,357.16,"other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","IDH1","ENSG00000138413","Citrate cycle (TCA cycle); Glutathione metabolism; Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids; Peroxisome; Central carbon metabolism in cancer","Peroxisomal protein import; Neutrophil degranulation; Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate; NADPH regeneration","Glutathione metabolism; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism",18336.5,17251.4,17761.3,16471.9,16563,15304.6,1.1036357430258898,0.142264086569282,0.031078295498055422,1.507542808278085,0.19683818179834234,0.7058906552138248,1154]
["O75879","Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial [OS=Homo sapiens]",11,5,11,5,557,61.8,8.63,26.29,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","other molecular function","GATB","ENSG00000059691","Aminoacyl-tRNA biosynthesis; Metabolic pathways","","",814.2,752.8,785.5,777.3,836.9,765.8,0.9884453781512604,-0.01676685057940686,0.7621285249458132,0.11797178329562573,0.8477244542427254,0.07174528860216814,6571]
["O75880","Protein SCO1 homolog, mitochondrial [OS=Homo sapiens]",5,2,5,2,301,33.8,8.88,12.22,"cell organization and biogenesis;other biological processes","other membranes;cytoskeleton;mitochondrion","other molecular function","SCO1","ENSG00000133028","","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis",937.8,916.2,948.1,968.9,1023.5,703.3,1.0394702674629968,0.055848492590553064,0.7391209622359456,0.13128448050552238,0.8317529042313359,0.0800056740305961,6495]
["O75882-1","Attractin [OS=Homo sapiens]",1,3,3,3,1429,158.4,7.31,6.16,"cell adhesion;stress response;developmental processes;other biological processes","extracellular matrix;plasma membrane;other membranes;other cell component","other molecular function","ATRN","ENSG00000088812","","","",491.8,520,462,502.7,528.6,399.5,1.0300531171372658,0.04271873532561441,0.7547527289476043,0.12219530803027925,0.8424691044407513,0.07444601688621012,6548]
["O75884-1","Putative hydrolase RBBP9 [OS=Homo sapiens]",16,3,3,3,186,21,6.2,8.55,"other biological processes","nucleus","other molecular function","RBBP9","ENSG00000089050; ENSPPAG00000038694; ENSPTRG00000013289","","","",424.1,443.4,630.1,629.3,542.8,1616.2,0.5371014596707671,-0.8967334526027864,0.2869389254041477,0.5422105324736783,0.5374773464323208,0.26963983564820465,3902]
["O75886","Signal transducing adapter molecule 2 [OS=Homo sapiens]",17,8,15,7,525,58.1,5.07,44.99,"cell organization and biogenesis;other metabolic processes;transport;signal transduction","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","STAM2","ENSG00000115145","Endocytosis; JAK-STAT signaling pathway","Ub-specific processing proteases; Endosomal Sorting Complex Required For Transport (ESCRT); RHOU GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell","EGF/EGFR signaling pathway",1152.5,1109.9,1166.7,1165.2,1212,1007.9,1.012998138902839,0.01863152359797398,0.83009825518205,0.08087049900000957,0.893416013418584,0.048946267582782026,6791]
["O75907","Diacylglycerol O-acyltransferase 1 [OS=Homo sapiens]",9,3,6,3,488,55.2,9.32,23.89,"cell organization and biogenesis;other metabolic processes;other biological processes","plasma membrane;other membranes;ER/Golgi","other molecular function","DGAT1","ENSG00000185000; ENSG00000285482","Glycerolipid metabolism; Retinol metabolism; Metabolic pathways; Fat digestion and absorption","Neutrophil degranulation; Acyl chain remodeling of DAG and TAG; Triglyceride biosynthesis","Triacylglyceride synthesis; Statin inhibition of cholesterol production; Glycerolipids and glycerophospholipids; Congenital generalized lipodystrophy (CGL); Vitamin A and carotenoid metabolism",472.4,500.4,436.8,416.8,415.5,494.6,1.0623257216067525,0.08722618130060396,0.4372856416085636,0.35923478259693425,0.6266903440229394,0.20294699681089767,5100]
["O75909","Cyclin-K [OS=Homo sapiens]",12,5,9,5,580,64.2,8.41,32.68,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","CCNK","ENSG00000090061","","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; RNA polymerase II transcribes snRNA genes","Male infertility",658.2,674.1,618.2,628.6,647.2,576.7,1.0529014844804319,0.07437045583136596,0.2907932445264517,0.5364156868740829,0.5402663508499835,0.267392080573428,3934]
["O75915","PRA1 family protein 3 [OS=Homo sapiens]",28,6,74,6,188,21.6,9.77,239.08,"other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi","","ARL6IP5","ENSG00000144746","","Glutamate Neurotransmitter Release Cycle","",7236.4,7045.3,6663.7,6170.4,6535.6,8579.9,0.9840034952715178,-0.023264654727390553,0.8897208692474943,0.050746222522965644,0.9282000903982209,0.03235839362066627,7006]
["O75925","E3 SUMO-protein ligase PIAS1 [OS=Homo sapiens]",4,2,4,1,651,71.8,7.3,11.56,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PIAS1","ENSG00000033800","Ubiquitin mediated proteolysis; JAK-STAT signaling pathway; Hepatitis C","SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of transcription cofactors; SUMOylation of intracellular receptors; Regulation of IFNG signaling; SUMOylation of transcription factors; Formation of Incision Complex in GG-NER","Androgen receptor signaling pathway; Interleukin-11 signaling pathway; Mesodermal commitment pathway; TGF-beta signaling pathway; Immune response to tuberculosis; Interferon type I signaling pathways",417.4,467,411.3,470.5,467,382.3,0.9817396575238673,-0.026587600485756147,0.8238190475460672,0.08416817092716301,0.8895395802207423,0.050834723140448575,6769]
["O75928-1","E3 SUMO-protein ligase PIAS2 [OS=Homo sapiens]",4,2,4,1,621,68.2,7.52,10.58,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PIAS2","ENSG00000078043; ENSPTRG00000009998","Ubiquitin mediated proteolysis; JAK-STAT signaling pathway","Activation of anterior HOX genes in hindbrain development during early embryogenesis","Androgen receptor signaling pathway; TGF-beta signaling pathway",74.7,54.1,87.9,65.8,72.4,40.1,1.2153673583847449,0.28139245046867867,0.40988341573699794,0.38733965328538955,0.6127710954431822,0.2127017286652522,4889]
["O75934","Pre-mRNA-splicing factor spf27 [OS=Homo sapiens]",31,7,15,7,225,26.1,5.66,52.21,"RNA metabolism OR transcription;other metabolic processes","cytoskeleton;nucleus;other cell component","","BCAS2","ENSG00000116752","Spliceosome","mRNA Splicing - Major Pathway","",1053,1040.6,1255.5,1514.6,1671.1,2946.4,0.5461587384419692,-0.8726077703369243,0.113223673618021,0.946062758247111,0.35809252724972546,0.44600474184224737,2311]
["O75935","Dynactin subunit 3 [OS=Homo sapiens]",45,7,19,7,186,21.1,5.47,63.76,"cell cycle OR cell proliferation;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","DCTN3","ENSG00000137100","Amyotrophic lateral sclerosis; Huntington disease; Pathways of neurodegeneration; Salmonella infection","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic","",2529.7,2731.2,2750.9,2600.6,2898.2,2779.9,0.9677606387476296,-0.04727783250505656,0.47039354131893024,0.3275386499183242,0.6477216265071705,0.18861160222674922,5308]
["O75937","DnaJ homolog subfamily C member 8 [OS=Homo sapiens]",12,3,7,3,253,29.8,9.06,20.11,"","non-structural extracellular;cytosol;nucleus","other molecular function","DNAJC8","ENSG00000126698; ENSG00000285317","","mRNA Splicing - Major Pathway","mRNA processing",891.1,813.7,835.1,947.1,826.4,502,1.1161942430235112,0.15858811055586036,0.5491624088062865,0.2602991986871866,0.7017181898540469,0.15383726559623784,5720]
["O75940","Survival of motor neuron-related-splicing factor 30 [OS=Homo sapiens]",29,4,9,4,238,26.7,7.24,25.68,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","SMNDC1","ENSG00000119953","Spliceosome","mRNA Splicing - Major Pathway","",319.8,334.5,322.6,424.6,410.3,895.7,0.564486305327632,-0.8249895138458079,0.19042206690279123,0.7202827251805175,0.449110967083737,0.3476463395358276,3099]
["O75943-1","cell cycle checkpoint protein RAD17 [OS=Homo sapiens]",5,3,6,3,681,77,7.06,17.38,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","other molecular function","RAD17","ENSG00000152942; ENSG00000276618","","Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA)","miRNA regulation of DNA damage response; Gastric cancer network 2; DNA damage response",424.8,474,426.2,485,449.7,308.9,1.065455130266967,0.09146983788422235,0.6542987795277053,0.18422388979620744,0.7779843467655764,0.10902914103309193,6147]
["O75947-1","ATP synthase subunit d, mitochondrial [OS=Homo sapiens]",41,6,30,6,161,18.5,5.3,46.16,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","ATP5PD","ENSG00000167863; ENSGGOG00000013716; ENSPTRG00000009628","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",1802.6,1692.4,2311.4,2101.4,2263.5,1748.1,0.949844593489285,-0.07423660517287432,0.6967409630142993,0.1569286555367611,0.8050078562553769,0.09419988123249218,6326]
["O75955","Flotillin-1 [OS=Homo sapiens]",43,17,73,16,427,47.3,7.49,227.45,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","FLOT1","ENSG00000137312; ENSG00000206379; ENSG00000206480; ENSG00000230143; ENSG00000232280","Insulin signaling pathway","RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Regulation of necroptotic cell death; Synaptic adhesion-like molecules","Angiopoietin-like protein 8 regulatory pathway; Insulin signaling",5942.5,6205.7,6317.2,5138.6,4898,5841.8,1.1629257355904878,0.2177589692821095,0.047099570583123175,1.3269830524088997,0.23692413034552465,0.6253907048229483,1453]
["O75962-1","Triple functional domain protein [OS=Homo sapiens]",4,7,9,6,3097,346.7,6.37,31.13,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;other cell component","enzyme regulator activity;kinase activity;other molecular function","TRIO","ENSG00000038382","","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; G alpha (q) signalling events; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; DCC mediated attractive signaling","Microtubule cytoskeleton regulation; Cell migration and invasion through p75NTR; Neural crest cell migration during development; Neural crest cell migration in cancer",316.9,340.4,304.8,345.4,310.9,370.8,0.9367150228799533,-0.09431789183896962,0.3451467898021604,0.46199616161419804,0.5792601347104455,0.23712635907390717,4355]
["O75962-3","Isoform 3 of Triple functional domain protein [OS=Homo sapiens]",4,2,2,1,596,66.2,7.08,5.3,"","","","TRIO","","","","",165.8,189.9,189.9,190.7,183.2,353.7,0.7498625618471689,-0.41530189862731365,0.3411390492480501,0.46706856525312507,0.577306161369298,0.23859380741665065,4319]
["O75964","ATP synthase subunit g, mitochondrial [OS=Homo sapiens]",30,3,27,3,103,11.4,9.64,83.87,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","ATP5MG","ENSG00000167283","Oxidative phosphorylation; Metabolic pathways; Thermogenesis","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",2962.2,3374.5,3331.4,2797.8,2748.8,1744.5,1.3260139073665154,0.40709590665976625,0.09720760601854513,1.0122997523304291,0.333407035377544,0.47702524016065817,2131]
["O75976","Carboxypeptidase D [OS=Homo sapiens]",11,11,15,11,1380,152.8,6.05,44.86,"protein metabolism;other metabolic processes","non-structural extracellular;plasma membrane;other membranes","other molecular function","CPD","ENSG00000108582","","Golgi Associated Vesicle Biogenesis; RND3 GTPase cycle; RND1 GTPase cycle","",1194.2,1177.7,1165.1,1315.8,1350.9,1142,0.9286633234436947,-0.10677243652917348,0.2367323818709336,0.6257423322442108,0.49649267692816457,0.30408715279426607,3485]
["O75995","SAM and SH3 domain-containing protein 3 [OS=Homo sapiens]",59,12,44,12,380,41.6,5.27,179.05,"other biological processes","nucleus;other cell component","","SASH3","ENSG00000122122","","","",3380.1,3033.2,2874,3914.9,3524.3,4284.5,0.7921816491380707,-0.33609681324107044,0.03770286269869732,1.423625673479948,0.2136203282672703,0.6703574218952241,1290]
["O76003","glutaredoxin-3 [OS=Homo sapiens]",36,11,63,11,335,37.4,5.39,205.95,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","GLRX3","ENSG00000108010","","Iron uptake and transport","",9110,9028.3,8886.3,9436.3,9781.2,9935.1,0.9270047954556369,-0.10935129286269281,0.011713231989500424,1.9313232550952022,0.12816169552583623,0.8922417556867748,668]
["O76021","Ribosomal L1 domain-containing protein 1 [OS=Homo sapiens]",44,21,75,21,490,54.9,10.13,204.17,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","RSL1D1","ENSG00000171490","","","Senescence and autophagy in cancer",9719.2,9625.7,9685.2,17856.3,17706.9,16358.4,0.5591141259129149,-0.8387853000416908,8.938886596693796E-5,4.048716572370221,0.020416975667260924,1.6900085888061545,32]
["O76024","Wolframin [OS=Homo sapiens]",18,13,34,13,890,100.2,8.05,95.23,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","WFS1","ENSG00000109501","Protein processing in endoplasmic reticulum","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; XBP1(S) activates chaperone genes","CAMKK2 pathway",3087.8,3235.3,3033.5,2999.6,3124.4,3463.7,0.975896200340019,-0.03520038892137925,0.6372412843185324,0.19569609575395194,0.7661780797967024,0.11567027725442004,6079]
["O76031","ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial [OS=Homo sapiens]",46,25,57,25,633,69.2,7.58,171.36,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","CLPX","ENSG00000166855","","","",6853.3,6356.5,6476.3,7453.4,7718.1,7069.6,0.8851225883611872,-0.17605081441160142,0.023990005470082714,1.6199696530064724,0.17551846844928384,0.7556771793484819,999]
["O76039-1","Cyclin-dependent kinase-like 5 [OS=Homo sapiens]",2,2,4,1,1030,115.5,9.54,11.44,"","","","CDKL5","","","","",226.3,240.4,230.4,219.9,161.5,103.8,1.4367271228359442,0.5227860771643427,0.10468499391380215,0.980115567867508,0.3449696215130658,0.4622191477966762,2218]
["O76062","Delta(14)-sterol reductase [OS=Homo sapiens]",16,4,8,4,418,46.4,8.87,24.51,"other metabolic processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","other molecular function","TM7SF2","ENSG00000149809","Steroid biosynthesis; Metabolic pathways","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways",709.5,687,695.2,582.3,511.7,578,1.251016746411483,0.32310110189629304,0.004170687349822834,2.3797923652574897,0.07796305329886213,1.1081111607693837,391]
["O76071","Probable cytosolic iron-sulfur protein assembly protein Ciao1 [OS=Homo sapiens]",43,10,29,10,339,37.8,4.97,123.12,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;other cell component","","CIAO1","ENSG00000144021","","Cytosolic iron-sulfur cluster assembly","",3287.5,3239.2,3294.3,3328.8,3171.5,2221.2,1.1260677635727798,0.1712936473371638,0.34971922790951315,0.45628048909357355,0.5823872947802761,0.23478810805457384,4389]
["O76074","cGMP-specific 3',5'-cyclic phosphodiesterase [OS=Homo sapiens]",18,14,21,14,875,99.9,6.09,54.97,"other metabolic processes;signal transduction","cytosol","other molecular function","PDE5A","ENSG00000138735","Purine metabolism; Metabolic pathways; cGMP-PKG signaling pathway","cGMP effects; RHOBTB1 GTPase cycle","Phosphodiesterases in neuronal function",1227.5,1247.3,1209.8,1482,1500.7,1847,0.7629045282315673,-0.3904255689741574,0.032803974098581455,1.4840735396866502,0.2013133893253836,0.6961273392854549,1191]
["O76075","DNA fragmentation factor subunit beta [OS=Homo sapiens]",12,3,6,3,338,39.1,9,17.17,"cell organization and biogenesis;DNA metabolism;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DFFB","ENSG00000169598","Apoptosis","Apoptosis induced DNA fragmentation","Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis",441.1,590.1,435.6,508.8,422.7,3393.7,0.33912882641265146,-1.5600946742662118,0.3849354312961872,0.41461211252654656,0.5992530494875041,0.22238974724470334,4695]
["O76080","AN1-type zinc finger protein 5 [OS=Homo sapiens]",8,1,1,1,213,23.1,8.51,4.43,"developmental processes;signal transduction;other biological processes","other cell component","nucleic acid binding activity;other molecular function","ZFAND5","ENSG00000107372","","","",80.5,84.7,68.7,108.3,110.2,108.1,0.7161665646050213,-0.4816329292092677,3.0791441722039506E-3,2.5115699760117893,0.06903516795901433,1.1609296141957552,326]
["O76094","Signal recognition particle subunit SRP72 [OS=Homo sapiens]",38,21,73,21,671,74.6,9.26,247.63,"transport","cytosol;ER/Golgi;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","SRP72","ENSG00000174780","Protein export","SRP-dependent cotranslational protein targeting to membrane","",9509.1,10385.3,10409.5,10519.1,9201.6,8103.1,1.089135919608393,0.12318400759829004,0.33706890239698056,0.47228131315797983,0.5750785732071734,0.2402728134338249,4284]
["O76095-1","Protein JTB [OS=Homo sapiens]",9,1,1,1,146,16.3,8.28,3.64,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion;other cell component","other molecular function","JTB","ENSG00000143543; ENSGGOG00000005608; ENSPPAG00000028370; ENSPTRG00000001369","","","",57.3,58.6,62,71.7,76.3,67.8,0.8243744207599629,-0.2786283542208571,0.011098756499348137,1.9547256766839252,0.12557401122869277,0.9011002327950363,646]
["O77932","Decapping and exoribonuclease protein [OS=Homo sapiens]",5,2,3,2,396,44.9,7.69,7.27,"RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus","nucleic acid binding activity;other molecular function","DXO","ENSG00000204348; ENSG00000206346; ENSG00000224313; ENSG00000225682; ENSG00000234798; ENSG00000236765","","","",383.9,360.3,335.5,384.9,367.5,363.2,0.9678200071710292,-0.047189331382428104,0.4823252129948968,0.3166600352409721,0.6552630077657436,0.18358434902338827,5380]
["O94760-1","N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 [OS=Homo sapiens]",33,8,25,7,285,31.1,5.81,85.27,"other metabolic processes;signal transduction;other biological processes","cytosol","other molecular function","DDAH1","ENSG00000153904; ENSMFAG00000037521; ENSMMUG00000014573; ENSMNEG00000044101; ENSRBIG00000034663; ENSRROG00000009892","","eNOS activation","Mesodermal commitment pathway; Nitric oxide metabolism in cystic fibrosis",3232.5,3116.5,2949.9,2876.7,2912.8,2412.7,1.1337080295530466,0.18104914243937584,0.11310937720642716,0.9465013888836467,0.35804089995746047,0.4460673599168499,2309]
["O94761","ATP-dependent DNA helicase Q4 [OS=Homo sapiens]",7,6,8,6,1208,133,8.09,22.05,"","","","","","","","",473.9,452.9,448.9,461.1,447.4,518,0.9643883631265333,-0.05231385224320189,0.5017914918311798,0.299476706676441,0.6690248109803161,0.17455777599594766,5482]
["O94762-1","ATP-dependent DNA helicase Q5 [OS=Homo sapiens]",6,5,7,5,991,108.8,8.56,19.38,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RECQL5","ENSG00000108469","","","",618,739.2,597.6,760.7,768.6,1122.2,0.7372430699603998,-0.4397877387814343,0.14177205990157654,0.8484093504377419,0.39580289756326315,0.4025210307685059,2618]
["O94763-1","Unconventional prefoldin RPB5 interactor 1 [OS=Homo sapiens]",10,5,6,5,535,59.8,5.05,19.81,"other biological processes","cytosol;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","URI1","ENSG00000105176","","","",703.9,731.7,693.7,787.8,830.6,502.8,1.0038185932491044,0.005498573804050045,0.9804380661597204,0.008579835320634704,0.9889624379742473,4.8202031351797835E-3,7246]
["O94766","Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 [OS=Homo sapiens]",18,4,7,4,335,37.1,8.27,23.83,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","enzyme regulator activity;other molecular function","B3GAT3","ENSG00000149541","Glycosaminoglycan biosynthesis; Glycosaminoglycan biosynthesis; Metabolic pathways","A tetrasaccharide linker sequence is required for GAG synthesis; Defective B3GAT3 causes JDSSDHD","Proteoglycan biosynthesis",589.2,567.7,579.1,565.6,560.6,748,0.9262618717319389,-0.11050796658734074,0.498497034858926,0.3023374205985368,0.6666998769961373,0.17606962500028542,5465]
["O94768","Serine/threonine-protein kinase 17B [OS=Homo sapiens]",16,5,12,5,372,42.3,5.25,31.11,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus","kinase activity;other molecular function","STK17B","ENSG00000081320","","","",860.8,892.8,806.6,922.7,877.1,2321,0.6212871287128712,-0.686667928801023,0.33456013309623667,0.47552581175335923,0.5742837042743997,0.24087350697169002,4258]
["O94776","Metastasis-associated protein MTA2 [OS=Homo sapiens]",41,28,99,27,668,75,9.66,247.68,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MTA2","ENSG00000149480","","Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation","Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome",10584,10724.8,10385.2,11132,10996.7,10456,0.9726650851473236,-0.0399849632350249,0.26419094542159605,0.5780820709789576,0.5211799244497829,0.2830123214103316,3705]
["O94788-1","retinal dehydrogenase 2 [OS=Homo sapiens]",3,2,5,1,518,56.7,6.05,11.85,"cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;other cell component","other molecular function","ALDH1A2","ENSG00000128918","Retinol metabolism; Metabolic pathways","RA biosynthesis pathway","Ethanol effects on histone modifications; Tryptophan metabolism; 22q11.2 copy number variation syndrome; Vitamin A and carotenoid metabolism",768.6,775,740.1,778.3,781,1723.3,0.6956985316517393,-0.5234658191456208,0.3497442522666778,0.4562494140180551,0.5821636847681959,0.23495488923846994,4391]
["O94804","Serine/threonine-protein kinase 10 [OS=Homo sapiens]",35,32,105,30,968,112.1,6.95,298.67,"cell adhesion;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol","kinase activity;other molecular function","STK10","ENSG00000072786","Progesterone-mediated oocyte maturation","RHOA GTPase cycle; RHOB GTPase cycle; Neutrophil degranulation; RHOC GTPase cycle","",11019.8,11574.1,11328.3,11283,10993.2,8945.6,1.0864908493424463,0.11967602388517211,0.2978900217409639,0.5259440438659099,0.5480186682367745,0.26120464703729984,3973]
["O94806","Serine/threonine-protein kinase D3 [OS=Homo sapiens]",18,12,29,9,890,100.4,6.87,95.06,"protein metabolism;other metabolic processes;signal transduction","other membranes;cytosol;nucleus","kinase activity;other molecular function","PRKD3","ENSG00000115825","Rap1 signaling pathway; Aldosterone synthesis and secretion; Chemical carcinogenesis","Sphingolipid de novo biosynthesis","G protein signaling pathways; Hippo signaling regulation pathways",2311.6,2385.1,2298.1,2691.5,2633.2,3264.2,{"$f":"AVERAGE(S706:U706)/AVERAGE(V706:X706)","v":0.8143999813713048},{"$f":"LOG(Y706,2)","v":-0.29619056647415504},{"$f":"TTEST(V706:X706,S706:U706,2,2)","v":0.05905176499486535},1.2287671172532582,{"$f":"AA706*7309/AE706","v":0.26205789335001267},0.5816027545390395,1647]
["O94811","Tubulin polymerization-promoting protein [OS=Homo sapiens]",24,4,5,4,219,23.7,9.44,10.69,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","TPPP","ENSG00000171368","","","Microtubule cytoskeleton regulation; Glial cell differentiation; Sudden infant death syndrome (SIDS) susceptibility pathways",516.2,506.7,521.8,435.5,410.6,309.8,1.3363612769270696,0.4183100841379069,0.028554079073641218,{"$f":"-LOG10(AA707)","v":1.5443318421420194},0.18921284129577848,{"$f":"-LOG10(AC707)","v":0.7230493926982371},1103]
["O94813","Slit homolog 2 protein [OS=Homo sapiens]",0,1,1,1,1529,169.8,7.06,1.9,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","non-structural extracellular;other membranes;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","SLIT2","ENSG00000145147","Axon guidance","Regulation of expression of SLITs and ROBOs; Netrin-1 signaling; Inactivation of CDC42 and RAC1; Activation of RAC1; Regulation of commissural axon pathfinding by SLIT and ROBO; Role of ABL in ROBO-SLIT signaling; SLIT2:ROBO1 increases RHOA activity","Spinal cord injury; Robo4 and VEGF signaling pathways crosstalk; Genes controlling nephrogenesis; GDNF/RET signaling axis; Development of ureteric collection system",159.4,188,186,172.1,165.3,13.5,1.5200911940723854,0.6041578771487596,0.3117116352034773,0.5062469865895167,0.5592293425876818,0.252410049369689,4074]
["O94822","E3 ubiquitin-protein ligase listerin [OS=Homo sapiens]",20,28,49,28,1766,200.4,6.25,119.14,"protein metabolism;other metabolic processes","cytosol;other cell component","translation activity;other molecular function","LTN1","ENSG00000198862","","Antigen processing: Ubiquitination & Proteasome degradation","",4265.7,4322.9,4315.8,4862.3,4536.2,4651.4,0.9184691705990788,-0.12269679834146197,0.01710417681796805,1.7668978225029948,0.1517165392749132,0.8189670723161375,824]
["O94826","Mitochondrial import receptor subunit TOM70 [OS=Homo sapiens]",57,28,155,28,608,67.4,7.12,436.56,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","TOMM70","ENSG00000154174","","Mitochondrial protein import; Ub-specific processing proteases; DDX58/IFIH1-mediated induction of interferon-alpha/beta; PINK1-PRKN Mediated Mitophagy","Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation",19500.8,19743.7,19276.1,18930.9,19424.1,14765.8,1.1016513305522506,0.13966768735957102,0.2917878760488491,0.5349327572488443,0.5406026834071073,0.26712180291031035,3945]
["O94829","Importin-13 [OS=Homo sapiens]",13,11,22,11,963,108.1,5.3,61.34,"transport","nucleus;other cell component","other molecular function","IPO13","ENSG00000117408","Nucleocytoplasmic transport","","",1609.5,1656.9,1634.5,1528.8,1463.9,2174.7,0.9484266749235593,-0.07639185505484851,0.7158579154232538,0.14517316857349138,0.8156204994276792,0.08851186740046572,6415]
["O94830","Phospholipase DDHD2 [OS=Homo sapiens]",5,3,3,3,711,81,5.39,2.46,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","DDHD2","ENSG00000085788","","Synthesis of PA","",89,88.6,86.5,85.4,77.2,94.5,1.0272267600155582,0.03875469133343703,0.6684298978846654,0.17494413299178513,0.7865970252196136,0.10424770035336288,6211]
["O94832","Unconventional myosin-Id [OS=Homo sapiens]",39,37,92,37,1006,116.1,9.39,237.91,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","MYO1D","ENSG00000176658","Pathogenic Escherichia coli infection","","",10932.6,11314.6,11500.5,9151.4,8683.2,9277.3,1.2447559927559484,0.3158629611348126,8.494402164806597E-4,3.070867181322536,0.04031531520946196,1.394529940275026,154]
["O94842","TOX high mobility group box family member 4 [OS=Homo sapiens]",11,5,6,4,621,66.2,5.06,17.83,"other biological processes","nucleus;other cell component","nucleic acid binding activity","TOX4","ENSG00000092203","","","",606.3,584.9,587.4,648.7,697,598.9,0.9146354005965238,-0.1287313357286318,0.13015917952093561,0.885525197706825,0.38038122475750435,0.4197809275533546,2501]
["O94854","Uncharacterized protein KIAA0754 [OS=Homo sapiens]",2,1,1,1,1291,135.1,4.21,2.88,"","","","KIAA0754","","","","",12,18.7,12.7,17.9,16.3,5.2,1.1015228426395938,0.13949941298810287,0.782879455693095,0.10630510353279765,0.8613677467500875,0.06481139409037419,6643]
["O94855","Protein transport protein Sec24D [OS=Homo sapiens]",22,19,48,18,1032,112.9,7.25,143.74,"cell organization and biogenesis;transport;developmental processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","SEC24D","ENSG00000150961","Protein processing in endoplasmic reticulum; Pathogenic Escherichia coli infection","MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Sterol regulatory element-binding proteins (SREBP) signaling",3608.4,3695,3944.8,4096.1,3868.7,3572,0.9749843977532765,-0.036548962654936415,0.6254233673931446,0.20382589645363366,0.7575769625913978,0.12057324040863028,6034]
["O94864-1","STAGA complex 65 subunit gamma [OS=Homo sapiens]",17,3,4,3,414,46.2,5.12,5.49,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","SUPT7L","ENSG00000119760; ENSPTRG00000011777","","HATs acetylate histones","",374.9,311.6,325.1,410.9,490.8,375.1,0.7922932330827066,-0.33589361455910766,0.08739446010878985,1.05851609620355,0.3192234427461994,0.49590522295578854,2001]
["O94868","F-BAR and double SH3 domains protein 2 [OS=Homo sapiens]",13,8,12,8,740,84.2,5.77,33.34,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","FCHSD2","ENSG00000137478","","","",795.6,806.7,742,1063.9,1058.2,1040.8,0.7411868854532232,-0.4320907403152018,2.0812344908828322E-4,3.6816789854494734,0.023402681375173262,1.630734380208356,65]
["O94874-1","E3 UFM1-protein ligase 1 [OS=Homo sapiens]",51,38,145,15,794,89.5,6.79,367.15,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","UFL1","ENSG00000014123","","Antigen processing: Ubiquitination & Proteasome degradation","",15045.1,15080.1,15374.6,13778.2,13336.4,12167.2,1.158292135289116,0.2119991643629727,0.01354009677711831,1.8683782315431747,0.13612732784588408,0.8660546805182398,727]
["O94874-3","Isoform 3 of E3 UFM1-protein ligase 1 [OS=Homo sapiens]",52,23,71,1,509,57.5,6.3,196.23,"","","","UFL1","","","","",41.7,57.6,69.2,51.3,34.9,11.4,1.7264344262295082,0.7877955385063345,0.16801077805511894,0.7746628569662797,0.4250573820716041,0.3715524369265037,2889]
["O94876","Transmembrane and coiled-coil domains protein 1 [OS=Homo sapiens]",11,5,7,5,653,72,6.55,21.85,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","TMCC1","ENSG00000172765","","","",190.1,201.2,195.4,177.2,164.3,316,0.8923193916349809,-0.16436790239566224,0.6530761703747996,0.18503616260815767,0.7770362574099643,0.10955871604374799,6143]
["O94880","PHD finger protein 14 [OS=Homo sapiens]",9,7,14,7,888,100,5.33,29.98,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","PHF14","ENSG00000106443","","","",1538.6,1541,1505.6,1787.5,1894.9,2230.1,0.7755095137420719,-0.3667836149228149,0.02973146448826049,1.5267836981443448,0.19281923153921557,0.7148496523064783,1127]
["O94886","CSC1-like protein 1 [OS=Homo sapiens]",18,10,23,10,807,92.1,7.27,71.54,"transport","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","transporter activity;nucleic acid binding activity","TMEM63A","ENSG00000196187","","Neutrophil degranulation","",2075.9,1994.5,2077.2,1983.4,1961.1,2328.4,0.9800251877122226,-0.0291092663528375,0.7493141389487453,0.12533607254071275,0.8393466730385256,0.07605862666705834,6525]
["O94887-1","FERM, RhoGEF and pleckstrin domain-containing protein 2 [OS=Homo sapiens]",11,7,7,7,1054,119.8,8.79,30.06,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity","FARP2","ENSG00000006607","Rap1 signaling pathway; Adherens junction","RAC1 GTPase cycle; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion","",581.7,657.1,634,500.7,469,1188.4,0.8678003799638571,-0.20456487705276657,0.707294722134298,0.15039958263083245,0.8111748194068075,0.09088553922672538,6373]
["O94888","UBX domain-containing protein 7 [OS=Homo sapiens]",42,16,38,15,489,54.8,5.16,97.06,"","other membranes;cytosol;ER/Golgi;nucleus","other molecular function","UBXN7","ENSG00000163960","","Neddylation","3q29 copy number variation syndrome",3894.8,3889.2,3846.5,4127.1,4283.4,6674,0.7710232357718187,-0.3751537566307715,0.23500147915837172,0.6289294041610424,0.49470789492181416,0.30565115878152377,3472]
["O94901-9","Isoform 9 of SUN domain-containing protein 1 [OS=Homo sapiens]",21,14,35,13,916,101.9,7.31,101.23,"","","","SUN1","","","","",2042,2019.2,1941.1,1782,1924.9,2456.9,0.9737986307148188,-0.03830462289228461,0.8081896989253257,0.09248668931578996,0.8794191617456015,0.05580407573050968,6717]
["O94903","Pyridoxal phosphate homeostasis protein [OS=Homo sapiens]",43,11,42,11,275,30.3,7.5,111.97,"","cytosol;other cell component","other molecular function","PLPBP","ENSG00000147471","","","",4661,4480,4595.3,4418.8,4563.5,4315.3,1.0329909156539527,0.04682756688581838,0.17695720562197467,0.7521317483802483,0.4348958358745841,0.3616147506822107,2974]
["O94905-1","Erlin-2 [OS=Homo sapiens]",32,10,32,7,339,37.8,5.62,86.04,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","ERLIN2","ENSG00000147475; ENSGGOG00000012855; ENSPPAG00000034728; ENSPTRG00000020158","","ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; Signaling by FGFR1 in disease; Signaling by plasma membrane FGFR1 fusions","",2914.8,2970.1,3101.6,2778.5,2740.5,2371.1,1.1389589485557852,0.18771574899308885,0.06085015941766231,1.2157382796505083,0.26552466578130973,0.5758951291393994,1675]
["O94906-1","Pre-mRNA-processing factor 6 [OS=Homo sapiens]",54,49,151,49,941,106.9,8.25,459.51,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","PRPF6","ENSG00000101161; ENSGGOG00000016876; ENSPPAG00000008686; ENSPTRG00000013765","Spliceosome","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","mRNA processing; mRNA Processing",18636.9,18676.5,18633.7,18138.1,17969.8,17196.7,1.0495735827677164,0.06980331362652732,0.03857196178869304,1.4137282721441404,0.21636413562053528,0.6648147259727522,1303]
["O94913","Pre-mRNA cleavage complex 2 protein Pcf11 [OS=Homo sapiens]",9,13,22,13,1555,172.9,8.48,58.17,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","PCF11","ENSG00000165494","mRNA surveillance pathway","RNA polymerase II transcribes snRNA genes; mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs","",2577,2502.6,2475.2,2663.5,2816.9,2522.7,0.9439842061201286,-0.08316537295149687,0.1730502801512249,0.7618276932896305,0.4302124141582662,0.36631706181781487,2940]
["O94915-1","protein furry homolog-like [OS=Homo sapiens]",9,26,41,20,3013,339.4,5.58,118.14,"cell organization and biogenesis;developmental processes;other biological processes","other cell component","","FRYL","ENSG00000075539","","","",4221.3,4096.5,4076.2,3780.5,3708.1,3843.5,1.0937072563778998,0.12922663548977534,0.004105286862711715,2.3866564905445506,0.0775336994303874,1.1105094936794893,387]
["O94915-2","Isoform 2 of Protein furry homolog-like [OS=Homo sapiens]",19,7,12,1,403,45.6,4.5,39.26,"","","","FRYL","","","","",322.2,367.9,330.1,300.7,286.7,341.2,1.0986431186732717,0.1357228198302813,0.23010053838754058,0.638082365171146,0.49032210935117615,0.3095185233299435,3430]
["O94916","nuclear factor of activated T-cells 5 [OS=Homo sapiens]",2,2,2,2,1531,165.7,5.24,2.25,"RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NFAT5","ENSG00000102908","","","Cancer immunotherapy by PD-1 blockade",111.8,97.9,103.4,100.1,112.7,130.2,0.9128279883381926,-0.1315850679215045,0.35860940804399594,0.4453783209980507,0.5876852384290507,0.2308552178262196,4460]
["O94919","endonuclease domain-containing 1 protein [OS=Homo sapiens]",25,8,25,8,500,55,5.71,78.53,"other metabolic processes","non-structural extracellular;cytosol","nucleic acid binding activity;other molecular function","ENDOD1","ENSG00000149218","","Platelet degranulation","",1512.1,1469.7,1440.7,1378.2,1398.8,1541.6,1.0240587227342193,0.03429844636171456,0.5657921469111082,0.24734308476315736,0.7129956554781536,0.14691311644212163,5800]
["O94921-1","Cyclin-dependent kinase 14 [OS=Homo sapiens]",14,6,12,4,469,53,8.92,26.99,"cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","CDK14","ENSCATG00000032271; ENSCSAG00000012501; ENSG00000058091; ENSGGOG00000003585; ENSMLEG00000038830; ENSMNEG00000032203; ENSPANG00000022338","Transcriptional misregulation in cancer","","",592.5,603.7,645.1,673,615.8,607.9,0.9707913744925399,-0.04276680472559227,0.5169303923090015,0.28656793325295515,0.6802744395726489,0.16731584678322098,5554]
["O94923","D-glucuronyl C5-epimerase [OS=Homo sapiens]",5,2,2,2,617,70.1,8.97,5.72,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","GLCE","ENSG00000138604","Glycosaminoglycan biosynthesis; Metabolic pathways","HS-GAG biosynthesis","",174.4,180.8,166.7,154.5,191.8,246.1,0.8809925725860906,-0.18279823866832864,0.4317157594376474,0.36480209748252096,0.6240922637914883,0.20475120087287663,5056]
["O94925-1","Glutaminase kidney isoform, mitochondrial [OS=Homo sapiens]",49,24,114,5,669,73.4,7.77,364.69,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;mitochondrion;other cell component","other molecular function","GLS","ENSG00000115419; ENSGGOG00000007590; ENSPTRG00000012747","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; D-Amino acid metabolism; Metabolic pathways; Glutamatergic synapse; GABAergic synapse; Proximal tubule bicarbonate reclamation; MicroRNAs in cancer; Central carbon metabolism in cancer","Glutamate Neurotransmitter Release Cycle; TP53 Regulates Metabolic Genes; Glutamate and glutamine metabolism","Amino acid metabolism; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling",13564.5,13507.6,13770,12737.1,12722.9,9590.2,1.1652458473846083,0.22063437151808668,0.13970649446645864,0.8547834045845509,0.39319013017148485,0.40539739232988065,2597]
["O94925-3","Isoform 3 of Glutaminase kidney isoform, mitochondrial [OS=Homo sapiens]",50,22,119,3,598,65.4,7.88,372.88,"","","","GLS","","","","",2446,2445.7,2410.7,2522.8,2554.2,1950,1.0391916891988044,0.05546179817747851,0.6650389229222958,0.17715293587630884,0.7847545185080821,0.10526617501310383,6194]
["O94927","HAUS augmin-like complex subunit 5 [OS=Homo sapiens]",6,3,5,3,633,71.6,8.51,15.7,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","","HAUS5","ENSG00000249115","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",210,246.5,223.7,232.9,213,223.9,1.015527022991938,0.022228630001126366,0.788729536737571,0.1030718951928039,0.8661094026464702,0.06242724659149851,6656]
["O94941-1","RING finger protein 37 [OS=Homo sapiens]",3,1,4,1,541,58.9,7.56,12.59,"protein metabolism;other metabolic processes","nucleus;other cell component","other molecular function","UBOX5","ENSG00000185019","Ubiquitin mediated proteolysis","Antigen processing: Ubiquitination & Proteasome degradation","",32.9,34.5,37.7,40.5,35.9,63.2,0.752865329512894,-0.40953627224747385,0.25007506915513794,0.6019296024240024,0.5092779828517423,0.29304509887326924,3589]
["O94953","lysine-specific demethylase 4B [OS=Homo sapiens]",8,6,13,6,1096,121.8,7.09,46.78,"cell organization and biogenesis;protein metabolism;other metabolic processes","nucleus","other molecular function","KDM4B","ENSG00000127663","","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Estrogen-dependent gene expression; HDMs demethylate histones","",449.7,449.4,469.7,454.6,461.1,446.6,1.0047713425823972,6.867222343922833E-3,0.7979263780754423,0.0980371776600275,0.8726685466636852,0.05915067689974781,6683]
["O94964-2","Isoform 2 of Protein SOGA1 [OS=Homo sapiens]",3,5,5,3,1661,183.7,6.52,15.95,"","","","SOGA1","","","","",233.6,259.2,242.3,290.8,299.1,1118.2,0.43036122006908256,-1.21638001265888,0.302880760303115,0.5187283131959382,0.5527479343459345,0.25747287173222166,4005]
["O94966-5","Isoform 5 of Ubiquitin carboxyl-terminal hydrolase 19 [OS=Homo sapiens]",14,12,20,12,1419,155.9,6.38,58.78,"","","","USP19","","","","",846.4,892.5,973.7,926.5,885.7,838.2,1.0234681557500755,0.03346621495912196,0.6697167106840125,0.17410886446935672,0.7870975138108132,0.10397145939890708,6219]
["O94973","AP-2 complex subunit alpha-2 [OS=Homo sapiens]",37,28,67,18,939,103.9,6.96,194.09,"transport","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","AP2A2","ENSG00000183020","Endocytosis; Synaptic vesicle cycle; Endocrine and other factor-regulated calcium reabsorption; Huntington disease","Neutrophil degranulation; MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; Recycling pathway of L1; Potential therapeutics for SARS; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation","Synaptic vesicle pathway; GABA receptor signaling; mBDNF and proBDNF regulation of GABA neurotransmission",3483.8,3591.9,3533.8,3156.2,3140.9,3008.8,1.140083173040759,0.18913907786051376,1.5128817757175455E-3,2.820195008632194,0.053418613037292464,1.272307392205139,207]
["O94979","Protein transport protein Sec31A [OS=Homo sapiens]",41,39,144,39,1220,132.9,6.89,421.07,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","SEC31A","ENSG00000138674","Protein processing in endoplasmic reticulum","Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Signaling by ALK fusions and activated point mutants; MHC class II antigen presentation; COPII-mediated vesicle transport; XBP1(S) activates chaperone genes","Sterol regulatory element-binding proteins (SREBP) signaling",17980.3,18278.9,18075.8,17881,16696.8,16012.8,1.0740137495898445,0.10301246291188104,0.08687427405758834,1.0611088114562275,0.31811827108562785,0.49741138652360684,1996]
["O94986-1","Isoform 1 of Centrosomal protein of 152 kDa [OS=Homo sapiens]",6,6,6,6,1275,147.3,5.43,14.01,"","","","CEP152","","","","",377.8,380.6,377,434.1,455.4,1351.4,0.5066714266589317,-0.9808776233977339,0.28979218975410276,0.5379133234625101,0.540053828381626,0.2675629509103024,3922]
["O94992","Protein HEXIM1 [OS=Homo sapiens]",4,2,2,2,359,40.6,4.89,2.06,"stress response;developmental processes;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","HEXIM1","ENSG00000186834","","","Initiation of transcription and translation elongation at the HIV-1 LTR",243.8,214.5,166.2,271.4,191,152,1.0164388020833335,0.023523355774163732,0.9396789511501522,0.02702050125119841,0.961382062423917,0.01710398524771543,7144]
["O95067","G2/mitotic-specific cyclin-B2 [OS=Homo sapiens]",12,3,3,3,398,45.3,8.9,12.41,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity","CCNB2","ENSG00000157456","FoxO signaling pathway; Cell cycle; Oocyte meiosis; p53 signaling pathway; Cellular senescence; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection; Human immunodeficiency virus 1 infection","Resolution of Sister Chromatid Cohesion; Initiation of Nuclear Envelope (NE) Reformation; The role of GTSE1 in G2/M progression after G2 checkpoint; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; Cyclin A/B1/B2 associated events during G2/M transition; Golgi Cisternae Pericentriolar Stack Reorganization; Polo-like kinase mediated events; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint","miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; TGF-beta signaling pathway; IL-18 signaling pathway; DNA damage response",384.4,441.2,414.8,364.3,327.7,299.4,1.2511599757918095,0.3232662671422956,0.02917551893330502,1.534981410591365,0.19073691223929018,0.7195652522577966,1118]
["O95070","protein YIF1A [OS=Homo sapiens]",2,1,3,1,293,32,8.95,3.54,"transport","other membranes;ER/Golgi;other cell component","","YIF1A","ENSG00000174851","","XBP1(S) activates chaperone genes","",257.9,243.2,236.2,215.1,237.3,832.4,0.5738636363636364,-0.8012201358855026,0.41793666458465323,0.3788895275682132,0.6177349001919576,0.20919786161743842,4945]
["O95071","E3 ubiquitin-protein ligase UBR5 [OS=Homo sapiens]",17,37,75,37,2799,309.2,5.85,229.82,"protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","UBR5","ENSG00000104517","Ubiquitin mediated proteolysis","","Mesodermal commitment pathway",7393.4,7087.8,7222.8,7174.1,7110.2,7044.9,1.0175721546049548,0.025131097587315385,0.2628652998083256,0.5802667402397942,0.5199681938563063,0.2840232210866658,3695]
["O95081","Arf-GAP domain and FG repeat-containing protein 2 [OS=Homo sapiens]",2,1,1,1,481,48.9,9.11,3.14,"","","enzyme regulator activity;other molecular function","AGFG2","ENSG00000106351","","","",84.6,67.1,69.9,55.8,67.2,77.5,1.1052369077306734,0.1443556447069058,0.4440112660581842,0.35260601023486565,0.6313771096535541,0.19971116734616845,5140]
["O95104","Splicing factor, arginine/serine-rich 15 [OS=Homo sapiens]",16,15,30,14,1147,125.8,9.55,88.37,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","SCAF4","ENSG00000156304","","","",2265.4,2396.8,2285.5,2597.2,2561.5,2973,0.8543969895593788,-0.22702153114303605,0.04575956116790718,1.3395181490592243,0.23388575704631717,0.6309962246403131,1430]
["O95136","Sphingosine 1-phosphate receptor 2 [OS=Homo sapiens]",3,1,1,1,353,38.8,8.97,2.94,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","S1PR2","ENSG00000267534","Sphingolipid signaling pathway; Neuroactive ligand-receptor interaction","G alpha (i) signalling events; Lysosphingolipid and LPA receptors","Small ligand GPCRs; S1P receptor signal transduction; Sphingolipid metabolism in senescence",35.8,50.2,49.8,42.9,34.1,57.1,1.0126771066368385,0.018174242340258336,0.9482495362500356,0.02307736102074239,0.9666326165204339,0.014738554804569518,7170]
["O95139","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [OS=Homo sapiens]",31,4,13,4,128,15.5,9.63,34.02,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB6","ENSG00000165264","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",913.6,921.4,1176.8,1164.8,1474.7,1949.2,0.6563514720944931,-0.6074595189801548,0.09744998192564945,1.0112182370962974,0.33345595407049244,0.47696152356884336,2136]
["O95140","Mitofusin-2 [OS=Homo sapiens]",18,12,18,12,757,86.3,6.98,52.88,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion","other molecular function","MFN2","ENSG00000116688","Mitophagy; NOD-like receptor signaling pathway; Parkinson disease; Pathways of neurodegeneration","Factors involved in megakaryocyte development and platelet production; PINK1-PRKN Mediated Mitophagy; RHOT2 GTPase cycle","Intracellular trafficking proteins involved in CMT neuropathy",1224.6,1238.9,1338.6,1250.4,1203.6,3013.7,0.6953746547908627,-0.5241376106143116,0.40487757665644825,0.3926762751062089,0.6102805130505219,0.21447049733776022,4849]
["O95149","Snurportin-1 [OS=Homo sapiens]",5,2,5,2,360,41.1,6.64,11.37,"transport","cytosol;nucleus","nucleic acid binding activity;other molecular function","SNUPN","ENSG00000169371","Nucleocytoplasmic transport","snRNP Assembly","",580.2,540.7,526.3,648.7,679.4,706.4,0.8096338166625707,-0.30465854532881853,0.005093823347006572,2.2929561203756528,0.08719146333318743,1.0595260335167036,427]
["O95155","Ubiquitin conjugation factor E4 B [OS=Homo sapiens]",21,21,35,20,1302,146.1,6.55,90.04,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","other molecular function","UBE4B","ENSG00000130939","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum","","",2773.7,2806.7,2749.2,2872.2,2844,2285.2,1.0410178218811708,0.057994767311198035,0.5990467772788299,0.22253926388633347,0.7381039944590303,0.13188244435870494,5932]
["O95159","Zinc finger protein-like 1 [OS=Homo sapiens]",12,3,9,3,310,34.1,8.07,41.08,"transport;other biological processes","other membranes;ER/Golgi;nucleus","nucleic acid binding activity;other molecular function","ZFPL1","ENSG00000162300","","","",861.8,934.4,776.5,1088.1,1111.3,1463.7,0.7023286287570638,-0.5097818504837148,0.048804522154208774,1.3115399350540886,0.24053422280857176,0.6188231241984977,1483]
["O95163","Elongator complex protein 1 [OS=Homo sapiens]",21,22,60,22,1332,150.2,5.94,211.47,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","ELP1","ENSG00000070061","","HATs acetylate histones","",5650,5561.6,5754.1,5656.9,5616.5,4565.4,1.0711480667727356,0.09915792026917186,0.3575555032508226,0.4466565332067452,0.5872748703955646,0.23115858230370379,4450]
["O95166","Gamma-aminobutyric acid receptor-associated protein [OS=Homo sapiens]",6,1,1,1,117,13.9,8.79,2.91,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","GABARAP","ENSG00000170296","FoxO signaling pathway; Autophagy; Mitophagy; Autophagy; NOD-like receptor signaling pathway; GABAergic synapse","Macroautophagy; TBC/RABGAPs","Senescence and autophagy in cancer",119.2,95.2,127.6,233.3,245.6,81.6,0.6101694915254237,-0.7127180479195291,0.24593821879545313,0.6091739766609472,0.50450812269884,0.2971318371279898,3563]
["O95167","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [OS=Homo sapiens]",49,3,11,3,84,9.3,8.46,20.56,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity","NDUFA3","ENSG00000170906; ENSG00000273642; ENSG00000274359; ENSG00000275605; ENSG00000275724; ENSG00000276061; ENSG00000276220; ENSG00000276766; ENSG00000277722; ENSG00000278365","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",1072,1089.5,1210.4,1248.2,1493.8,758,0.9633999999999999,-0.05379317096247219,0.8559608813075337,0.06754608277668273,0.9092018720355709,0.041339678739102236,6881]
["O95168-1","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [OS=Homo sapiens]",14,1,1,1,129,15.2,9.85,5.37,"cell organization and biogenesis;other metabolic processes;stress response;transport","other membranes;mitochondrion;nucleus","transporter activity","NDUFB4","ENSG00000065518; ENSGGOG00000013923; ENSPPAG00000027750; ENSPTRG00000015270","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",61,62.1,73.8,54.2,68,286,0.4823615874571288,-1.0518130711311657,0.40189304695026756,0.39588950736171563,0.60904753890929,0.21534880739962534,4823]
["O95169","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [OS=Homo sapiens]",28,4,7,4,186,21.8,6.8,13.42,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;ER/Golgi","transporter activity","NDUFB8","ENSG00000166136","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Mitochondrial protein import; Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",726.1,851.5,764.9,726.9,834.8,1961.3,0.6649162645472609,-0.5887554269484143,0.3771083482313374,0.4235338532993057,0.5945394558289139,0.22581931870689118,4636]
["O95182","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [OS=Homo sapiens]",5,1,1,1,113,12.5,10.18,0,"protein metabolism;other metabolic processes;transport","other membranes;mitochondrion;translational apparatus","transporter activity;other molecular function","NDUFA7","ENSG00000267855","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",115,99.2,106.1,103.3,107.3,181.8,0.8162589194699287,-0.2929012434445551,0.40650526114848956,0.39093382922619474,0.6107187983009887,0.2141587119465925,4865]
["O95183","vesicle-associated membrane protein 5 [OS=Homo sapiens]",16,2,2,1,116,12.8,7.85,5.66,"transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","VAMP5","ENSG00000168899","SNARE interactions in vesicular transport","","",54.5,59.2,60.1,38.7,38,81.8,1.0965299684542587,0.13294524178763056,0.7442743240583601,0.12826696302090773,0.8361360335909244,0.07772306008276957,6506]
["O95197","Reticulon-3 [OS=Homo sapiens]",3,4,20,4,1032,112.5,4.96,41.5,"cell organization and biogenesis;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","","RTN3","ENSG00000133318","Alzheimer disease","Synaptic adhesion-like molecules","Alzheimer's disease and miRNA effects; Alzheimer's disease",3786.4,4157.7,4080.3,3711.6,3401.7,5506,0.952857923973596,-0.06966697798108712,0.7805901724119975,0.10757692076436168,0.8602734575029085,0.06536347642260587,6632]
["O95202-1","mitochondrial proton/calcium exchanger protein [OS=Homo sapiens]",48,34,143,34,739,83.3,6.7,456.4,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity;translation activity;other molecular function","LETM1","ENSG00000168924","","RHOG GTPase cycle; Mitochondrial calcium ion transport","",14658.5,14380.6,13575.9,12055.3,13086.7,8128.8,1.2808528800028853,0.3571047758517958,0.11399168960243368,0.943126809114076,0.3597432034992175,0.4440074022855016,2316]
["O95208-1","epsin-2 [OS=Homo sapiens]",7,5,7,4,641,68.4,7.52,20.07,"transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","EPN2","ENSG00000072134","Endocytosis","Cargo recognition for clathrin-mediated endocytosis","",504.6,475.8,509.9,578.9,661.9,950,0.6802537885703852,-0.5558550085186393,0.10755350260378338,0.9683754417458263,0.34783564182789944,0.45862591900925426,2260]
["O95210","Starch-binding domain-containing protein 1 [OS=Homo sapiens]",39,15,34,15,358,39,5.73,84.87,"other metabolic processes;transport","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","STBD1","ENSG00000118804","","Neutrophil degranulation; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle","Exercise-induced circadian regulation",5035.9,5177.1,4764.6,4578.3,4673.6,5107.1,1.043080994498224,0.06085118645224803,0.3667721165107653,0.43560368855766296,0.5908612297943979,0.2285145059397067,4537]
["O95218-1","Zinc finger Ran-binding domain-containing protein 2 [OS=Homo sapiens]",35,13,50,13,330,37.4,10.01,133.31,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","ZRANB2","ENSANAG00000018241; ENSCANG00000036472; ENSCATG00000025001; ENSG00000132485; ENSGGOG00000023501; ENSMFAG00000003326; ENSMLEG00000036639; ENSMNEG00000042080; ENSNLEG00000009455; ENSPANG00000013398; ENSPPAG00000037049; ENSPTRG00000000856; ENSSBOG00000013268","","","",8150.8,7720.9,7394.8,7434.9,8154.6,6001,{"$f":"AVERAGE(S770:U770)/AVERAGE(V770:X770)","v":1.0776267339802228},{"$f":"LOG(Y770,2)","v":0.10785754702483702},{"$f":"TTEST(V770:X770,S770:U770,2,2)","v":0.45113272181931396},0.3456956712614635,{"$f":"AA770*7309/AE770","v":0.6356909704602595},0.1967539573710755,5187]
["O95219","sorting nexin-4 [OS=Homo sapiens]",11,5,6,5,450,51.9,5.99,13.91,"transport;other biological processes","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","SNX4","ENSG00000114520","Endocytosis","","",392.2,336.5,417.3,334.1,334.5,251.1,1.246058497336088,0.31737179856711273,0.10829449595843464,{"$f":"-LOG10(AA771)","v":0.9653936157257792},0.34853565431977046,{"$f":"-LOG10(AC771)","v":0.4577527880615415},2271]
["O95229","ZW10 interactor [OS=Homo sapiens]",8,2,2,2,277,31.3,5.15,5.15,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","ZWINT","ENSG00000122952","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",190.1,196.9,225.9,325.7,411.9,405.6,0.5361266620013996,-0.8993542116414329,0.004066349565096043,2.3907952898232354,0.07760038895897384,1.1101361019078853,383]
["O95232-1","Luc7-like protein 3 [OS=Homo sapiens]",49,22,71,22,432,51.4,9.79,189.39,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity","LUC7L3","ENSCANG00000028098; ENSCATG00000034891; ENSG00000108848; ENSGGOG00000024399; ENSMLEG00000034172; ENSMMUG00000010117; ENSPPAG00000025115; ENSPTRG00000009409; ENSRROG00000039925","","","",6997.7,6932.3,7189.3,7671.2,8059.8,11482.6,0.7760568245289121,-0.3657658014123341,0.16939976869878987,0.7710871869976837,0.42533250065938,0.3712714305525216,2911]
["O95235","kinesin-like protein KIF20A [OS=Homo sapiens]",19,14,24,14,890,100.2,6.92,75.44,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","KIF20A","ENSG00000112984","","COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Mitotic Telophase/Cytokinesis","",1434.1,1586.2,1504.6,1083.2,1061.5,1186.7,1.3582577895179206,0.44175732079289304,2.4439796148787727E-3,2.6119024208446158,0.06289805283503151,1.2013627990076805,284]
["O95236-1","Apolipoprotein L3 [OS=Homo sapiens]",24,10,18,10,402,44.3,8.16,43.95,"protein metabolism;other metabolic processes;stress response;transport","non-structural extracellular;other cell component","transporter activity;other molecular function","APOL3","ENSG00000128284","","","",1288.7,1251.2,1230.1,1437.7,1525.3,1517.7,0.8413863905193386,-0.24915961227988936,1.9588872396119118E-3,2.7079905627922845,0.05867830669804698,1.231522427247041,244]
["O95239-1","Chromosome-associated kinesin KIF4A [OS=Homo sapiens]",32,33,76,33,1232,139.8,6.27,222.16,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","KIF4A","ENSG00000090889; ENSGGOG00000006631; ENSPTRG00000021996","","MHC class II antigen presentation; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins","Retinoblastoma gene in cancer",6616.6,6349.8,6693.4,5325.5,5550,5923.6,1.170288884523576,0.22686470145434762,0.009350239486880255,2.0291772654377924,0.11563604130221283,0.9369067844350748,591]
["O95243","Methyl-CpG-binding domain protein 4 [OS=Homo sapiens]",24,11,15,1,580,66,8.82,29.4,"DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus","nucleic acid binding activity;other molecular function","MBD4","ENSG00000129071","Base excision repair","Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Displacement of DNA glycosylase by APEX1","Base excision repair; DNA repair pathways, full network",1725.6,1929.6,1728.8,2233.3,2174.8,2735.7,0.7536605168117808,-0.4080132809466347,0.03688676037064465,1.4331294855954901,0.21079384796641262,0.6761420681901711,1279]
["O95243-2","Isoform 2 of Methyl-CpG-binding domain protein 4 [OS=Homo sapiens]",24,11,15,1,574,65.3,8.84,29.64,"","","","MBD4","","","","",193.9,170.8,186.1,164.8,192.8,122.9,1.1463059313215402,0.1969921284738516,0.3353007350448681,0.4745654945115907,0.5746103335153437,0.2406265681311596,4265]
["O95248-1","Myotubularin-related protein 5 [OS=Homo sapiens]",26,36,70,36,1867,208.2,6.9,212.66,"","","","","","","","",5863.2,6077.5,5748.8,5126.6,5074.6,8227.3,0.9598990693762379,-0.05904537630924996,0.8255140525280363,0.08327552944729505,0.8908433795847361,0.0501986431696833,6773]
["O95249-1","Golgi SNAP receptor complex member 1 [OS=Homo sapiens]",24,7,11,7,250,28.6,9.42,33.73,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","GOSR1","ENSG00000108587","SNARE interactions in vesicular transport","Intra-Golgi traffic; COPI-mediated anterograde transport","",1618.5,1681.2,1570.6,1982.7,1958.6,1478.4,0.8986290754100779,-0.1542023534451956,0.3352258097817962,0.4746625514549549,0.5747514528958828,0.24051992221811413,4263]
["O95251-1","Histone acetyltransferase KAT7 [OS=Homo sapiens]",9,7,13,7,611,70.6,8.85,30.93,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","KAT7","ENSAMEG00000012243; ENSANAG00000032052; ENSCANG00000040077; ENSCATG00000030056; ENSCJAG00000007037; ENSDLEG00000005028; ENSECAG00000010150; ENSG00000136504; ENSGGOG00000007469; ENSMLEG00000043692; ENSMNEG00000044419; ENSPANG00000022824; ENSPCTG00005022544; ENSPPAG00000041097; ENSPPYG00000008925; ENSPTRG00000009383; ENSRFEG00010021504","","HATs acetylate histones","Androgen receptor signaling pathway; Androgen receptor signaling pathway",1453.6,1445.5,1417.2,1739,1705.1,1827.9,0.8187215477996965,-0.28855522899756897,1.1347179724337866E-3,2.9451120664318378,0.04582129094209142,1.3389326794170493,181]
["O95260","Arginyl-tRNA--protein transferase 1 [OS=Homo sapiens]",22,8,18,8,518,59.1,7.93,49.56,"protein metabolism;other metabolic processes","nucleus;other cell component","other molecular function","ATE1","ENSG00000107669","","","",941.2,925.2,934.9,944.3,990.5,965.2,0.9659655172413795,-0.04995640581885446,0.08060289410020988,1.0936493642844107,0.30795951540953165,0.5115063724277336,1913]
["O95263-4","Isoform 4 of High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [OS=Homo sapiens]",1,1,2,1,865,96.7,6.83,1.82,"","","","PDE8B","","","","",156.6,165.7,189.1,138.1,132.6,46.3,1.613249211356467,0.6899693202148793,0.10689135454566362,0.9710574194399418,0.3480039689863053,0.45841580289531086,2245]
["O95271","Tankyrase-1 [OS=Homo sapiens]",1,1,1,1,1327,142,7.05,0,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","TNKS","ENSG00000173273","","Degradation of AXIN; Ub-specific processing proteases; Regulation of PTEN stability and activity; XAV939 stabilizes AXIN","NAD+ biosynthetic pathways; Regulation of Wnt / B-catenin signaling by small molecule compounds",43,49.7,64.5,44,56,77.3,0.88663282571912,-0.1735913186400823,0.5952767986355652,0.22528104407500354,0.735815680911102,0.13323096119013614,5913]
["O95273-1","Cyclin-D1-binding protein 1 [OS=Homo sapiens]",8,3,8,3,360,40.2,4.82,20.1,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","","CCNDBP1","ENSG00000166946","","","",584.3,600.7,619.9,509.4,526,410.2,1.2485473159933589,0.3202504958800539,0.03333253381860256,1.4771316715896627,0.20285386318082105,0.6928167171085959,1201]
["O95292","Vesicle-associated membrane protein-associated protein B/C [OS=Homo sapiens]",44,10,36,9,243,27.2,7.3,130.67,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","VAPB","ENSG00000124164","Cholesterol metabolism; Amyotrophic lateral sclerosis; Pathways of neurodegeneration","RHOA GTPase cycle; Sphingolipid de novo biosynthesis; RHOC GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOD GTPase cycle","Ciliary landscape",5378.1,5154.7,5117.2,5028,5651.5,3906.3,1.072961373390558,0.101598140007807,0.5303652000820508,0.2754249799052413,0.6875557373890935,0.16269208955685188,5638]
["O95295","SNARE-associated protein Snapin [OS=Homo sapiens]",14,2,4,2,136,14.9,9.31,12.19,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SNAPIN","ENSG00000143553","","Golgi Associated Vesicle Biogenesis","",110.6,114.5,185.8,138.7,204.6,292,0.6467810483236267,-0.6286506886331319,0.21401869028546516,0.6695482979900655,0.4738753733100469,0.32433586043640417,3301]
["O95297-1","Myelin protein zero-like protein 1 [OS=Homo sapiens]",3,1,2,1,269,29.1,8.72,4.69,"cell-cell signaling;signal transduction","plasma membrane;other membranes","other molecular function","MPZL1","ENSG00000197965","Cell adhesion molecules","","",441.6,402.8,433.8,391.6,390,223.7,1.2714612553466629,0.3464875001161991,0.18542589898579762,0.7318296067552955,0.44362615243443365,0.35298285944989555,3055]
["O95298-1","NADH dehydrogenase [ubiquinone] 1 subunit C2 [OS=Homo sapiens]",30,5,22,5,119,14.2,8.98,49.67,"cell organization and biogenesis;other metabolic processes;transport","plasma membrane;other membranes;mitochondrion;other cytoplasmic organelle;other cell component","transporter activity","NDUFC2","ENSG00000151366; ENSGGOG00000041901","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Neutrophil degranulation; Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",2488.9,2699.1,3119.7,2414.3,3329.6,2422.1,1.0173524369336273,0.024819552287435806,0.9008362775230512,0.04535413269384236,0.9353903043636853,0.029007136013117548,7039]
["O95299","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [OS=Homo sapiens]",35,10,24,10,355,40.7,8.48,57.68,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;other cell component","transporter activity","NDUFA10","ENSG00000130414","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation",2365.8,2490.3,2395.7,2313.7,2151,1836.9,1.15078710168846,0.2026209561912475,0.0940891887508672,1.0264602759944599,0.3288846870301714,0.4829563469281589,2091]
["O95319-1","CUGBP Elav-like family member 2 [OS=Homo sapiens]",17,9,36,8,508,54.3,8.76,79.13,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","CELF2","ENSANAG00000024646; ENSCATG00000032144; ENSG00000048740; ENSPANG00000023401; ENSPPYG00000002083; ENSSBOG00000028844","","","mRNA processing",4625.8,4566.7,4833.7,4932.1,4745.6,3931.1,1.030671330315678,0.04358434655720472,0.6841533064976573,0.16484656976277254,0.795874027883396,0.0991556675947388,6283]
["O95336","6-phosphogluconolactonase [OS=Homo sapiens]",38,6,21,6,258,27.5,6.05,60.85,"other metabolic processes","cytosol;other cell component","other molecular function","PGLS","ENSG00000130313","Pentose phosphate pathway; Metabolic pathways; Carbon metabolism","Pentose phosphate pathway","Pentose phosphate metabolism",1432.9,1499,1436.9,1278.8,1449.5,1581.1,1.013783821413654,0.019750045808095747,0.8367985772973239,0.077379066852096,0.8973240612479666,0.04705068672676673,6816]
["O95340","bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [OS=Homo sapiens]",29,15,34,13,614,69.5,8.03,114.36,"other metabolic processes;developmental processes","cytosol","kinase activity;other molecular function","PAPSS2","ENSG00000198682","Purine metabolism; Selenocompound metabolism; Sulfur metabolism; Metabolic pathways","Transport and synthesis of PAPS; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se; Defective PAPSS2 causes SEMD-PA","RANKL/RANK signaling pathway; Proteoglycan biosynthesis; Sulfation biotransformation reaction",3196.3,3098.7,3098.5,3110.3,3173.4,3454.9,0.9645636949869589,-0.05205158506535417,0.35789107906950346,0.44624912686613977,0.5874300240105548,0.23104386011338982,4453]
["O95347-1","structural maintenance of chromosomes protein 2 [OS=Homo sapiens]",48,65,205,65,1197,135.6,8.43,553.65,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMC2; SMC2L1","ENSG00000136824","","Condensation of Prophase Chromosomes; Condensation of Prometaphase Chromosomes","Retinoblastoma gene in cancer",23890.2,24312.2,23434.2,25197.5,25235.8,21413.2,0.9970784937331674,-4.2210114654678875E-3,0.9594396710095239,0.017982328246261264,0.9747768356142077,0.0110947998447806,7194]
["O95352","Ubiquitin-like modifier-activating enzyme ATG7 [OS=Homo sapiens]",6,3,3,3,703,77.9,6.24,2.83,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;cytosol;cytoskeleton;other cell component","other molecular function","ATG7","ENSG00000197548","Autophagy; Autophagy; Ferroptosis; Neutrophil extracellular trap formation","Neutrophil degranulation; Antigen processing: Ubiquitination & Proteasome degradation; Signaling by BRAF and RAF1 fusions; Macroautophagy","Nanoparticle triggered autophagic cell death; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Senescence and autophagy in cancer",50.6,68.8,57.6,55.8,66.6,49.9,1.0272780034822984,0.038826658745411684,0.8386412064798219,0.07642380242953382,0.898509026408827,0.04647755561693929,6822]
["O95359","Transforming acidic coiled-coil-containing protein 2 [OS=Homo sapiens]",1,4,12,1,2948,309.2,4.79,28.04,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","TACC2","ENSG00000138162","","","",68.3,76.5,59.2,62.6,57,34,1.328125,0.4093909361377018,0.17079393887563088,0.7675275455883179,0.42751126686369384,0.3690524351527633,2920]
["O95363","phenylalanine--tRNA ligase, mitochondrial [OS=Homo sapiens]",7,3,6,3,451,52.3,7.46,19.74,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","FARS2","ENSG00000145982","Aminoacyl-tRNA biosynthesis","Mitochondrial tRNA aminoacylation","",949.2,1006.7,899.6,986,922.1,1049,0.9656420141354707,-0.050439647184803954,0.5190076548411489,0.28482623669729457,0.68116842327778,0.16674549270308067,5569]
["O95365","Zinc finger and BTB domain-containing protein 7A [OS=Homo sapiens]",11,3,4,3,584,61.4,5.19,20.38,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBTB7A","ENSG00000178951","","","IL-18 signaling pathway",108.5,99.7,101.6,110.5,105,441.6,0.4714655303606756,-1.0847757979966666,0.3571182963025026,0.4471878989540574,0.5874808975185666,0.23100625031095537,4443]
["O95372","acyl-protein thioesterase 2 [OS=Homo sapiens]",29,5,22,5,231,24.7,7.23,67.04,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes","cytosol;ER/Golgi;other cell component","other molecular function","LYPLA2","ENSG00000011009","Glycerophospholipid metabolism","L1CAM interactions","",2883.3,2894.9,3003.2,2578.5,2839.4,3622.7,0.9713293365484594,-0.041967559647056174,0.7981132627565171,0.09793547218349981,0.8726117931918299,0.05917892189753004,6685]
["O95373","Importin-7 [OS=Homo sapiens]",36,27,146,26,1038,119.4,4.82,481.3,"stress response;transport;signal transduction;other biological processes","cytosol;nucleus","transporter activity;enzyme regulator activity;other molecular function","IPO7","ENSG00000205339","Nucleocytoplasmic transport","","",13896.2,14637.9,14377.6,13352.1,12832.8,13001.7,1.0950605564146925,0.13101065249632715,0.009493067047797907,2.0225934517731656,0.11680947315211264,0.932521934870386,594]
["O95376","E3 ubiquitin-protein ligase ARIH2 [OS=Homo sapiens]",25,9,23,9,493,57.8,5.63,62.16,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","other molecular function","ARIH2","ENSG00000177479","","Antigen processing: Ubiquitination & Proteasome degradation","Modulators of TCR signaling and T cell activation",1258.7,1340.6,1328.5,1311.3,1263.7,1596.6,0.9415571962796048,-0.0868793587493029,0.48997745705547563,0.3098239005870485,0.6616008190686258,0.1794039657941369,5413]
["O95379","Tumor necrosis factor alpha-induced protein 8 [OS=Homo sapiens]",24,4,10,4,198,23,7.93,27.88,"other biological processes","nucleus;other cell component","enzyme regulator activity","TNFAIP8","ENSG00000145779","","PI Metabolism","",234.2,200.5,205.7,246.4,301.5,73.8,1.0300788161492682,0.04275472897881161,0.9327322910175623,0.030242987783099768,0.9566854217018471,0.019230843914123587,7126]
["O95391","Pre-mRNA-splicing factor SLU7 [OS=Homo sapiens]",16,8,13,8,586,68.3,7.14,34.85,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SLU7","ENSG00000164609","Spliceosome","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway","",700.2,676.6,722.3,971.9,921.8,1091.9,0.703074758842444,-0.5082499938158465,0.00478786411257614,2.319858184079288,0.0851447659338662,1.069842044071384,411]
["O95394","phosphoacetylglucosamine mutase [OS=Homo sapiens]",23,14,33,14,542,59.8,6.25,91.25,"protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol","other molecular function","PGM3","ENSG00000013375","Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars","Synthesis of UDP-N-acetyl-glucosamine","Glucuronidation",5036.5,5564.6,6074.3,5312,4315.6,2833,1.3382501645185625,0.4203478300114719,0.14604706479557922,0.8355071669060616,0.3991989516046704,0.39881060794805423,2674]
["O95396","Adenylyltransferase and sulfurtransferase MOCS3 [OS=Homo sapiens]",14,6,11,6,460,49.6,6.21,33.72,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;other cell component","other molecular function","MOCS3","ENSG00000124217","Sulfur relay system","Molybdenum cofactor biosynthesis","",1134,1087,1026.7,1097.1,1073.9,956,1.038599296450272,0.05463915325349327,0.4945962785578652,0.30574915568168504,0.6647672305957036,0.17733039704919346,5438]
["O95400","CD2 antigen cytoplasmic tail-binding protein 2 [OS=Homo sapiens]",50,10,33,10,341,37.6,4.61,102.7,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","CD2BP2","ENSG00000169217","","mRNA Splicing - Major Pathway","mRNA processing; Ciliary landscape",1937.5,1791.1,1944.6,2214,2251.9,2548.7,0.808770279132096,-0.3061981131466502,0.01877594159302345,1.7263982743823587,0.1579210093249809,0.8015600889470521,869]
["O95425","Supervillin [OS=Homo sapiens]",1,2,2,2,2214,247.6,6.98,2.04,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","SVIL","ENSG00000197321","","","",260.1,262.1,239.7,238.3,246.5,64,1.3883017492711374,0.4733211737256939,0.30160175903283626,0.5205661298578785,0.5520679330756324,0.2580074781682432,3993]
["O95427","GPI ethanolamine phosphate transferase 1 [OS=Homo sapiens]",2,2,2,2,931,105.7,8.65,5.83,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;ER/Golgi","other molecular function","PIGN","ENSG00000197563","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways","Synthesis of glycosylphosphatidylinositol (GPI)","",245.4,240.7,223.8,227.5,234.3,316.6,0.9119989722507708,-0.13289589629729248,0.480394327155202,0.3184021297032259,0.6545865281837008,0.18403293699881426,5364]
["O95433","activator of 90 kDa heat shock protein ATPase homolog 1 [OS=Homo sapiens]",71,19,101,19,338,38.3,5.53,313.06,"other biological processes","cytosol;ER/Golgi","other molecular function","AHSA1","ENSG00000100591","","","T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection",12284.2,11985.2,12413.3,12479.5,11762.3,13363.3,0.9754714121222919,-0.03582850210816108,0.5567020254911046,0.25437719856371077,0.7080102843769764,0.14996043381343538,5747]
["O95453","poly(A)-specific ribonuclease PARN [OS=Homo sapiens]",26,16,30,16,639,73.4,6.2,64.2,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PARN","ENSG00000140694; ENSG00000274829","RNA degradation","Deadenylation of mRNA; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA","Lung fibrosis",2315.2,2384.2,2351.3,2446.3,2346.3,2285.3,0.9961570522330068,-0.0055548820962009,0.8674963195857621,0.061732359058109136,0.9157323223356926,0.03823145637749242,6924]
["O95456","Proteasome assembly chaperone 1 [OS=Homo sapiens]",48,9,19,9,288,32.8,7.17,59.26,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes","cytosol;ER/Golgi;nucleus;other cell component","other molecular function","PSMG1","ENSG00000183527","","","",1544.9,1609.1,1671.6,1557.1,1473.4,791.7,1.2625189681335358,0.3363050631330406,0.24415563538523188,0.6123332472616319,0.5032525490780202,0.298214016642558,3546]
["O95461-1","LARGE xylosyl- and glucuronyltransferase 1 [OS=Homo sapiens]",5,4,6,3,756,88,7.84,7.11,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","LARGE; LARGE1","ENSG00000133424; ENSPTRG00000014294","Mannose type O-glycan biosynthesis; Metabolic pathways","Defective LARGE causes MDDGA6 and MDDGB6; O-linked glycosylation","",115.6,155.2,129.2,115.9,116.4,174,0.9844942160964802,-0.0225453645690012,0.93016583167403,0.031439617724919725,0.9551253250499416,0.019939639508773907,7118]
["O95466-2","Isoform 2 of Formin-like protein 1 [OS=Homo sapiens]",42,47,196,5,1104,122.3,5.83,583.57,"","","","FMNL1","","","","",23817,22964.2,23067.5,21633.8,22308.1,22747.6,1.0473717751670053,0.06677363232185085,0.06660753469112134,1.1764766403538904,0.2797899258950608,0.5531679267525171,1740]
["O95470","sphingosine-1-phosphate lyase 1 [OS=Homo sapiens]",5,3,8,3,568,63.5,9.16,14.54,"other metabolic processes;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","SGPL1","ENSG00000166224","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway","Sphingolipid de novo biosynthesis","Sphingolipid pathway; Kennedy pathway from sphingolipids; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway",597.2,662,615,597.9,558.2,338.6,1.2538971030976116,0.3264189630190484,0.20181011847290933,0.6950570626442839,0.4603714594002791,0.336891608172511,3204]
["O95476","CTD nuclear envelope phosphatase 1 [OS=Homo sapiens]",4,1,1,1,244,28.4,9.76,3.48,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","CTDNEP1","ENSG00000175826; ENSG00000288307","","Depolymerisation of the Nuclear Lamina","Development of ureteric collection system",157.2,151.7,160.2,144.7,164.4,125,1.080626583736466,0.11186807824310006,0.3730265197322471,0.42826029161232576,0.5934808081678263,0.22659332058736004,4594]
["O95478","Ribosome biogenesis protein NSA2 homolog [OS=Homo sapiens]",26,6,10,6,260,30,10.27,28.21,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","","NSA2","ENSG00000164346","","","",962.7,1079.7,1037.5,2118.4,1893.5,2250.7,0.4917925462268068,-1.023878225758803,6.4036799174532852E-4,3.193570384054094,0.03519135076441057,1.4535640631372069,133]
["O95479","GDH/6PGL endoplasmic bifunctional protein [OS=Homo sapiens]",3,2,2,2,791,88.8,7.3,6.86,"other metabolic processes;other biological processes","mitochondrion;ER/Golgi","other molecular function","H6PD","ENSG00000049239","Pentose phosphate pathway; Metabolic pathways; Carbon metabolism","","Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism",104.9,113.9,123.9,78.6,87.6,236.5,0.8510057114477281,-0.23275928042657923,0.7175024466111277,0.14417661369097282,0.816730319620111,0.08792132172349443,6421]
["O95486-1","Protein transport protein Sec24A [OS=Homo sapiens]",9,9,26,9,1093,119.7,7.66,77.11,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi","other molecular function","SEC24A","ENSG00000113615","Protein processing in endoplasmic reticulum; Pathogenic Escherichia coli infection","MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Sterol regulatory element-binding proteins (SREBP) signaling",2025.4,2079.3,1991.8,2292.8,2132.7,2255.6,0.9124994387151818,-0.13210442341893175,0.023501326038220072,1.6289076324161602,0.17350625455893992,0.7606848651297371,990]
["O95487-1","Protein transport protein Sec24B [OS=Homo sapiens]",13,13,27,13,1268,137.3,6.67,85.07,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","SEC24B","ENSG00000138802","Protein processing in endoplasmic reticulum; Pathogenic Escherichia coli infection","COPII-mediated vesicle transport; MHC class II antigen presentation; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Sterol regulatory element-binding proteins (SREBP) signaling",2177.6,2415.8,2257.2,2329.4,2196.8,2879.7,0.925019241415628,-0.11244471930577456,0.4484150905182607,0.34831978051387963,0.633571601894059,0.19820429703898923,5173]
["O95503","Chromobox protein homolog 6 [OS=Homo sapiens]",2,1,1,1,412,43.9,10.01,2.47,"cell organization and biogenesis;other biological processes","nucleus;other cell component","","CBX6","ENSG00000183741","","Regulation of PTEN gene transcription; Oxidative Stress Induced Senescence; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","",72.2,85.1,94.2,250.5,265.5,195.1,0.3536774012093939,-1.4994940562407593,0.0023674280419959,2.625723212510134,0.061798326996242964,1.2090232819683804,280]
["O95544","NAD kinase [OS=Homo sapiens]",7,2,3,2,446,49.2,6.47,11.27,"other metabolic processes;other biological processes","cytosol","kinase activity;other molecular function","NADK","ENSG00000008130","Nicotinate and nicotinamide metabolism; Metabolic pathways; Biosynthesis of cofactors","Nicotinate metabolism","NAD+ metabolism",205.8,257.1,260.3,266,220.1,432.5,0.787284998911387,-0.34504210580575606,0.3853726825601999,0.4141190738887722,0.5991680359141675,0.22245136319305184,4701]
["O95551-1","Tyrosyl-DNA phosphodiesterase 2 [OS=Homo sapiens]",21,5,10,5,362,40.9,5.1,40.15,"DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TDP2","ENSG00000111802","","Nonhomologous End-Joining (NHEJ)","Oxidative damage response",821.4,861.9,1099.7,1262.3,1310.1,1721.3,0.6481589305261196,-0.6255804852211486,0.041171807866539074,1.38540006258173,0.22224870287779477,0.6531607650468825,1354]
["O95562","Vesicle transport protein SFT2B [OS=Homo sapiens]",17,2,2,2,160,17.8,9.13,7.37,"transport","other membranes","","SFT2D2","ENSG00000213064","","","TYROBP causal network in microglia",186.5,183,165.9,210.4,178.2,136.5,1.019615311369263,0.028024943312538724,0.8851894211654892,0.052963784935590966,0.9259838957061056,0.033396566305961155,6987]
["O95563","Mitochondrial pyruvate carrier 2 [OS=Homo sapiens]",28,4,16,4,127,14.3,10.43,39.48,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MPC2","ENSG00000143158","Diabetic cardiomyopathy","Pyruvate metabolism","Glycolysis and gluconeogenesis",2183.7,2660.5,2646.9,1886.3,2199,1261.4,1.4010698187667157,0.4865288506143541,0.08721109475877158,1.059428261787523,0.3188723819869242,0.4963830940216669,1999]
["O95568","histidine protein methyltransferase 1 homolog [OS=Homo sapiens]",8,2,3,2,372,42.1,6.76,10.13,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","METTL18","ENSG00000171806","","","",127.4,124.8,124.9,151.2,167,193.2,0.7373875635510364,-0.4395050100999848,0.021841785048979215,1.6607118712217828,0.16893291737882443,0.7722857178470729,945]
["O95571","Persulfide dioxygenase ETHE1, mitochondrial [OS=Homo sapiens]",20,4,16,4,254,27.9,6.83,64.11,"other metabolic processes","mitochondrion;nucleus;other cell component","other molecular function","ETHE1","ENSG00000105755","Sulfur metabolism; Metabolic pathways","Sulfide oxidation to sulfate","",2477.5,2179.8,2392.3,2091.7,2255.7,2730.3,0.9960297836867911,-5.7392118964242214E-3,0.966711805210345,0.014702977893709503,0.9801215958222239,0.008720041533299064,7209]
["O95573","long-chain-fatty-acid--CoA ligase 3 [OS=Homo sapiens]",27,15,45,12,720,80.4,8.38,138.07,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ACSL3","ENSG00000123983","Fatty acid biosynthesis; Fatty acid degradation; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; Peroxisome; Ferroptosis; Thermogenesis; Adipocytokine signaling pathway","Synthesis of very long-chain fatty acyl-CoAs; Intracellular metabolism of fatty acids regulates insulin secretion","Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Ciliary landscape; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters",4370.1,4399.4,4311.3,3863.6,3917.7,4242.2,1.0879361250883686,0.12159385555570656,0.043586688971060196,1.360646120571979,0.22869713545547662,0.6407392751119697,1393]
["O95602","DNA-directed RNA polymerase I subunit RPA1 [OS=Homo sapiens]",21,29,61,28,1720,194.7,7.03,192.23,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POLR1A","ENSG00000068654","RNA polymerase","B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","Pyrimidine metabolism; Eukaryotic transcription initiation",4217.6,4429.6,4322.4,4977.8,4693.8,5136.2,0.8758627209983927,-0.19122332923319668,0.012845690506033056,1.8912425457456465,0.13298746729262834,0.8761892849134774,706]
["O95613","Pericentrin [OS=Homo sapiens]",23,67,104,67,3336,377.8,5.55,318.42,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton","other molecular function","PCNT","ENSG00000160299","","Late endosomal microautophagy; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Chaperone Mediated Autophagy","",8591.5,8834.7,8819.9,10737.7,10715.2,9884,0.8375461516614597,-0.25575940480139453,0.004347657340252721,2.3617446920700305,0.08024501893915945,1.0955819161115696,396]
["O95619","YEATS domain-containing protein 4 [OS=Homo sapiens]",22,5,8,5,227,26.5,8.41,21.32,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","other membranes;nucleus","cytoskeletal activity;other molecular function","YEATS4","ENSG00000127337","","HATs acetylate histones; Activation of the TFAP2 (AP-2) family of transcription factors","",695.7,784.5,843.5,1176.8,1013.7,851.9,0.7637720220878254,-0.3887860216596192,0.08093187327939827,1.0918804071486534,0.30873228695152505,0.510417950007206,1916]
["O95620","tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like [OS=Homo sapiens]",7,1,1,1,317,35.8,7.33,4.6,"RNA metabolism OR transcription;other metabolic processes","","other molecular function","DUS4L","ENSG00000105865; ENSG00000284103","","","",11.5,17.9,13,11.4,11.8,26.7,0.849699398797595,-0.2349755507740616,0.6670501868381777,0.17584148985116219,0.785732444093512,0.10472531380193782,6205]
["O95625","Zinc finger and BTB domain-containing protein 11 [OS=Homo sapiens]",3,3,4,3,1053,119.3,8.66,12.07,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZBTB11","ENSG00000066422","","","",422.2,462.5,440.8,469.2,517.3,587.7,0.842014991741837,-0.24808217475595476,0.08459176898224881,1.0726718929834074,0.31480714841713675,0.5019554145503652,1964]
["O95628-6","Isoform 6 of CCR4-NOT transcription complex subunit 4 [OS=Homo sapiens]",14,7,14,7,767,84.7,7.3,39.71,"","","","CNOT4","","","","",947.9,954.1,907.4,1032.5,979.5,1323.2,0.8423482849604221,-0.24751122846836793,0.17941449661860798,0.7461424690560753,0.43725927168569717,0.35926097293162945,2999]
["O95630","STAM-binding protein [OS=Homo sapiens]",21,10,22,10,424,48,6.29,53.17,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle","other molecular function","STAMBP","ENSG00000124356","Endocytosis","Metalloprotease DUBs","EGF/EGFR signaling pathway",3440.6,3515.3,3416.2,4026.2,3963,4309.2,{"$f":"AVERAGE(S834:U834)/AVERAGE(V834:X834)","v":0.8433698692512848},{"$f":"LOG(Y834,2)","v":-0.245762614956644},{"$f":"TTEST(V834:X834,S834:U834,2,2)","v":0.004370210636263822},2.3594976303150497,{"$f":"AA834*7309/AE834","v":0.08045810967368332},1.0944301751941916,397]
["O95639","Cleavage and polyadenylation specificity factor subunit 4 [OS=Homo sapiens]",18,5,10,5,269,30.2,8.31,21.81,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CPSF4","ENSG00000160917","mRNA surveillance pathway; Influenza A","mRNA Splicing - Major Pathway; Transport of Mature mRNA Derived from an Intronless Transcript; tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Inhibition of Host mRNA Processing and RNA Silencing","mRNA processing",1086.7,1080.2,1059.7,1235.5,1197.8,788.6,1.001458766566312,2.103021754784884E-3,0.9918022751317859,{"$f":"-LOG10(AA835)","v":3.5748997996508532E-3},0.9957531358431624,{"$f":"-LOG10(AC835)","v":1.8483172287151223E-3},7280]
["O95671-1","N-acetylserotonin O-methyltransferase-like protein [OS=Homo sapiens]",24,12,24,12,621,68.8,6.07,76.91,"other metabolic processes","cytosol","other molecular function","ASMTL","ENSG00000169093","Pyrimidine metabolism","","",2604.9,2748.7,2589,2241,2038.3,2061.1,1.2526969907261372,0.3250374898053365,0.00284118556675755,2.546500400213369,0.06742280943971082,1.1711931548298402,308]
["O95674-1","phosphatidate cytidylyltransferase 2 [OS=Homo sapiens]",31,9,25,8,445,51.4,7.09,87.87,"cell organization and biogenesis;other metabolic processes","other membranes;mitochondrion;ER/Golgi","other molecular function","CDS2","ENSG00000101290","Glycerophospholipid metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of PG","",2090.1,2123.8,2025,1898.8,1987.2,2023.5,1.0557407564091716,0.07825561560615463,0.07985389589769701,1.0977038907265313,0.3068623160443047,0.5130564414439535,1902]
["O95684","FGFR1 oncogene partner [OS=Homo sapiens]",34,7,10,7,399,43,4.81,32.64,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","CEP43","ENSG00000213066","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease","Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome",496.3,451.9,504.1,431.5,506.1,464.4,1.035877318116976,0.050853150684026814,0.5685461121031021,0.24523430596342763,0.7147408898110721,0.14585137151386368,5814]
["O95696","Bromodomain-containing protein 1 [OS=Homo sapiens]",5,4,5,4,1058,119.4,8.6,10.81,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","other molecular function","BRD1","ENSG00000100425","","HATs acetylate histones; Regulation of TP53 Activity through Acetylation","Pathways affected in adenoid cystic carcinoma",404.4,402.8,437.2,396.5,423.5,528.8,0.9225978647686833,-0.11622614140770034,0.45280127866110487,0.34409235541811095,0.6364470280257722,0.19623773716893714,5200]
["O95707","Ribonuclease P protein subunit p29 [OS=Homo sapiens]",12,2,3,2,220,25.4,10.07,9.23,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POP4","ENSG00000105171","Ribosome biogenesis in eukaryotes","tRNA processing in the nucleus","",155.5,187.3,189.5,164.1,156.1,164.4,1.098431696244325,0.1354451614741393,0.23270672491175323,0.6331910660047839,0.4932869641473331,0.3069003612734862,3448]
["O95714","E3 ubiquitin-protein ligase HERC2 [OS=Homo sapiens]",4,14,22,14,4834,526.9,6.28,62.99,"protein metabolism;DNA metabolism;other metabolic processes;stress response;transport","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","HERC2","ENSG00000128731","Ubiquitin mediated proteolysis","SUMOylation of DNA damage response and repair proteins; Antigen processing: Ubiquitination & Proteasome degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)","Prader-Willi and Angelman syndrome",1220.1,1299.1,1223.5,1443.4,1392.7,1602.6,0.8431973325523238,-0.24605779185865484,0.02734466177894068,1.5631274439641691,0.1869617707598479,0.7282471872889742,1069]
["O95716","ras-related protein Rab-3D [OS=Homo sapiens]",31,7,25,4,219,24.3,4.93,56.46,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB3D","ENSG00000105514","Pancreatic secretion","Neutrophil degranulation; RAB geranylgeranylation","",1104.7,1129,1092,1021.7,1067.2,958.1,1.091467016737775,0.1262685338946001,0.0499522388005841,1.3014450424339792,0.24405141269616926,0.6125186740784486,1496]
["O95721","Synaptosomal-associated protein 29 [OS=Homo sapiens]",22,6,7,6,258,29,5.81,17.87,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","SNAP29","ENSG00000099940","SNARE interactions in vesicular transport; Autophagy","Intra-Golgi traffic; Neutrophil degranulation","Ciliary landscape; 22q11.2 copy number variation syndrome",991.4,935.1,1182.6,1131.8,1162.4,1261.6,0.8743742617695033,-0.1936771606707877,0.15293897693883365,0.8154818192818166,0.4088628319114613,0.3884223676296471,2734]
["O95747","Serine/threonine-protein kinase OSR1 [OS=Homo sapiens]",31,13,59,11,527,58,6.43,200.91,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol","kinase activity;other molecular function","OXSR1","ENSG00000172939","","","",4963.5,4855,4725.8,4489.1,4383.1,4095.8,1.1215530536705736,0.16549786693072818,0.018138284061811945,1.7414038009438084,0.15505581076933744,0.8095119537880081,855]
["O95749","geranylgeranyl pyrophosphate synthase [OS=Homo sapiens]",12,4,7,4,300,34.8,6.14,18.08,"other metabolic processes","cytosol","other molecular function","GGPS1","ENSG00000152904","Terpenoid backbone biosynthesis; Metabolic pathways","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways",1076.3,962.5,1028.8,997.2,1042.3,557.9,1.1810271810271809,0.24004216836069892,0.3773146974707916,0.42329627747554144,0.5946082630043156,0.22576905989353704,4638]
["O95757","Heat shock 70 kDa protein 4L [OS=Homo sapiens]",56,41,192,36,839,94.5,5.88,590.57,"stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","HSPA4L","ENSG00000164070","Protein processing in endoplasmic reticulum","Regulation of HSF1-mediated heat shock response","",17595.6,17253.6,17282,18043.3,18086.7,13930.3,1.0413681100592684,0.05848013269370351,0.643805302389163,0.191245450780459,0.77001684751471,0.11349977261631253,6111]
["O95758-1","Isoform 1 of Polypyrimidine tract-binding protein 3 [OS=Homo sapiens]",17,8,57,3,521,56.5,9.22,133.39,"","","","PTBP3","","","","",1161.4,994.7,1130.4,1111,1324.3,3166,0.5867387927802475,-0.7692097146021042,0.3036835308817779,0.5175787597481984,0.5532459938222619,0.25708172221260595,4012]
["O95772-1","STARD3 N-terminal-like protein [OS=Homo sapiens]",7,2,3,2,234,26.6,4.81,4.26,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","STARD3NL","ENSCANG00000042172; ENSCATG00000036966; ENSCSAG00000015104; ENSG00000010270; ENSGGOG00000013471; ENSMFAG00000043802; ENSMLEG00000030425; ENSMMUG00000023659; ENSMNEG00000034363; ENSPANG00000016262; ENSPPAG00000039214; ENSPTRG00000019094; ENSRBIG00000036179; ENSRROG00000026971","","Pregnenolone biosynthesis","",558.5,583.7,604.5,562,544.8,501.1,1.0863237763542508,0.11945415924088941,0.10870724321478466,0.9637415177038569,0.34909544844326057,0.4570558135429174,2276]
["O95777","U6 snRNA-associated Sm-like protein LSm8 [OS=Homo sapiens]",59,4,23,4,96,10.4,4.48,78.7,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","LSM8","ENSG00000128534","RNA degradation; Spliceosome","mRNA Splicing - Major Pathway","",926.6,940.1,1038,949.3,944.4,574.8,1.1767065019242453,0.23475452341760278,0.32238132786460966,0.49163012021744645,0.5664146935967385,0.2468654889602162,4160]
["O95782","AP-2 complex subunit alpha-1 [OS=Homo sapiens]",38,32,95,22,977,107.5,7.03,261.06,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","AP2A1","ENSG00000196961","Endocytosis; Synaptic vesicle cycle; Endocrine and other factor-regulated calcium reabsorption; Huntington disease","MHC class II antigen presentation; Recycling pathway of L1; Potential therapeutics for SARS; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Trafficking of GluR2-containing AMPA receptors; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation","Synaptic vesicle pathway; VEGFA-VEGFR2 signaling pathway; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; mBDNF and proBDNF regulation of GABA neurotransmission",11426,11811.9,12070.9,10116.4,10056.4,11456.9,1.116317891096027,0.15874791838712815,0.06805137213984756,1.1671631135648879,0.2838969628825033,0.5468392535129769,1752]
["O95785-3","Isoform 3 of Protein Wiz [OS=Homo sapiens]",14,8,13,8,965,102.9,9.52,28.55,"","","","WIZ","","","","",483,520.9,472.2,553.4,560.3,717.5,0.8060834425513325,-0.3109989063524192,0.10026435843440451,0.998853420779512,0.33817821679606025,0.47085437021535703,2167]
["O95793","double-stranded RNA-binding protein Staufen homolog 1 [OS=Homo sapiens]",12,6,9,6,577,63.1,9.44,22.2,"cell organization and biogenesis;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","nucleic acid binding activity;other molecular function","STAU1","ENSG00000124214","","","",626.7,672.8,635.9,764.5,765.9,685.8,0.873296633877809,-0.195456315563367,0.035470828252783575,1.4501286705240006,0.2082379788751768,0.6814400600717829,1245]
["O95801","Tetratricopeptide repeat protein 4 [OS=Homo sapiens]",36,10,23,10,387,44.7,5.6,68.81,"stress response","nucleus;other cell component","other molecular function","TTC4","ENSG00000243725","","","",2400.6,2428.8,2437,3270.8,3444.9,2597.3,0.7802426715344142,-0.3580051932595193,0.05775045952699769,1.2384445556913093,0.2613610580079419,0.582759120474458,1615]
["O95816","BAG family molecular chaperone regulator 2 [OS=Homo sapiens]",33,8,15,8,211,23.8,6.7,43.88,"protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","BAG2","ENSG00000112208","Protein processing in endoplasmic reticulum","Regulation of HSF1-mediated heat shock response","Malignant pleural mesothelioma",1417.6,1280.3,1821.6,1806.5,1986.7,1400.3,0.8702223933763358,-0.20054395275344966,0.3979616196448369,0.40015881028863304,0.6059794745800235,0.21754208578024728,4800]
["O95817","BAG family molecular chaperone regulator 3 [OS=Homo sapiens]",4,2,3,2,575,61.6,6.95,7.24,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","BAG3","ENSG00000151929","","Regulation of HSF1-mediated heat shock response","",144,130.9,112,142.6,86.3,252.2,0.8041987112866349,-0.31437607063900513,0.5609709288824574,0.25105964454253504,0.7107187587453425,0.14830222161670437,5769]
["O95819","Mitogen-activated protein kinase kinase kinase kinase 4 [OS=Homo sapiens]",7,7,7,4,1239,142,7.46,21.82,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","other cell component","cytoskeletal activity;kinase activity;other molecular function","MAP4K4","ENSG00000071054","MAPK signaling pathway","Oxidative Stress Induced Senescence","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Insulin signaling; Malignant pleural mesothelioma",229.3,245.5,232.2,234.4,248,323.2,0.8776067527308838,-0.18835346831002345,0.30649916831787455,0.513570699597272,0.5556057592349566,0.2552332611507679,4032]
["O95822","Malonyl-CoA decarboxylase, mitochondrial [OS=Homo sapiens]",18,6,6,6,493,55,8.95,22.43,"other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","MLYCD","ENSG00000103150","beta-Alanine metabolism; Propanoate metabolism; Metabolic pathways; Peroxisome; AMPK signaling pathway; Alcoholic liver disease","","",509.5,475,480,450,466.9,891.2,0.8099662629279355,-0.3040662774088749,0.47302513539706076,0.3251157813040284,0.6490220977317659,0.18774051620488513,5327]
["O95825-1","Quinone oxidoreductase-like protein 1 [OS=Homo sapiens]",11,2,3,2,349,38.7,5.78,10.21,"other metabolic processes","","other molecular function","CRYZL1","ENSG00000205758","","","",252,276.2,266.5,236.9,234,141.4,1.297893189612935,0.37617166133690333,0.13148682696283043,0.8811177548846552,0.38197027753232415,0.41797042977391347,2516]
["O95831-1","Apoptosis-inducing factor 1, mitochondrial [OS=Homo sapiens]",47,23,87,23,613,66.9,8.95,288.87,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","AIFM1","ENSG00000156709","Apoptosis; Necroptosis","","Apoptosis modulation and signaling; Nanomaterial induced apoptosis; Apoptosis modulation by HSP70",9769.6,9384.5,9539.7,9088.5,8936.1,7357.7,1.1304649302860657,0.1769162369482146,0.12218557202271614,0.9129800736422107,0.3705619692589346,0.431139154333106,2410]
["O95834-3","Isoform 3 of Echinoderm microtubule-associated protein-like 2 [OS=Homo sapiens]",14,12,29,12,850,92,7.06,75.05,"","","","EML2","","","","",3780.5,3798.9,3742.3,3489,3410.4,3541.9,1.08431900242307,0.11678925439401446,0.002144714232950367,2.6686305660995666,0.06123326690872748,1.2130125695274432,256]
["O95835","Serine/threonine-protein kinase LATS1 [OS=Homo sapiens]",1,1,1,1,1130,126.8,8.7,3.38,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","LATS1","ENSG00000131023","Hippo signaling pathway; Hippo signaling pathway","Signaling by Hippo","Mesodermal commitment pathway; Transcription co-factors SKI and SKIL protein partners; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Overview of leukocyte-intrinsic Hippo pathway functions; Malignant pleural mesothelioma",23,23.3,31.6,27.8,21.3,48.6,0.797338792221085,-0.3267352339067161,0.49042720227990555,0.309425449027127,0.6615969770143649,0.17940648784030352,5418]
["O95841","Angiopoietin-related protein 1 [OS=Homo sapiens]",2,1,1,1,491,56.7,8.21,0,"developmental processes;signal transduction","non-structural extracellular;extracellular matrix","signal transduction activity or receptor binding","ANGPTL1","ENSG00000116194","","","RAC1/PAK1/p38/MMP2 pathway",57.4,60.7,51.7,54.7,48.9,58,1.0507425742574257,0.07140926080124367,0.5053386536801292,0.2964174810256886,0.6719156302979924,0.1726852561074462,5497]
["O95848","uridine diphosphate glucose pyrophosphatase [OS=Homo sapiens]",7,1,1,1,222,24.1,5.05,3.49,"protein metabolism;other metabolic processes","cytosol","other molecular function","NUDT14","ENSG00000183828","","Synthesis of dolichyl-phosphate-glucose","",36.7,39.7,37.7,42,36.2,57.5,0.8408253500368462,-0.25012192913017206,0.3247610395878309,0.4884360770506602,0.5685457337359177,0.24523459498630815,4175]
["O95861-1","3'(2'),5'-bisphosphate nucleotidase 1 [OS=Homo sapiens]",60,14,59,13,308,33.4,5.69,154.82,"other metabolic processes;developmental processes","cytosol","other molecular function","BPNT1; HEL20","ENSG00000162813; ENSPTRG00000001996","Sulfur metabolism; Metabolic pathways","Cytosolic sulfonation of small molecules","",6550.5,6324,6336,5863,5608.1,4592.2,1.1959248722242628,0.25812676255121314,0.056661041622854263,1.2467154459310115,0.2593209475400387,0.5861624001855215,1597]
["O95865","N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 [OS=Homo sapiens]",53,12,36,11,285,29.6,6.01,135.24,"other metabolic processes;signal transduction;other biological processes","cytosol;mitochondrion","other molecular function","DDAH2","ENSG00000206395; ENSG00000213722; ENSG00000225635; ENSG00000226634; ENSG00000227317; ENSG00000228128; ENSG00000233076","","eNOS activation","Nitric oxide metabolism in cystic fibrosis",3896.4,3896.4,3747.6,3466.9,3500.3,5286.7,0.9417736394127583,-0.08654775324453243,0.7134670936954788,0.14662605248070276,0.8142927838570041,0.08921941384399193,6404]
["O95870-1","Protein ABHD16A [OS=Homo sapiens]",26,11,30,11,558,63.2,8.13,82.31,"other metabolic processes","other membranes","other molecular function","ABHD16A","ENSG00000204427; ENSG00000206403; ENSG00000224552; ENSG00000230475; ENSG00000231488; ENSG00000235676; ENSG00000236063; ENSGGOG00000009970","","","IL-18 signaling pathway",1939.9,1890,2026.5,1722.3,1820.7,2555.7,0.9602702215226195,-0.0584876553101625,0.7765008760294682,0.10985804997463787,0.8573179611630488,0.06685807753036481,6620]
["O95873","Uncharacterized protein C6orf47 [OS=Homo sapiens]",10,3,5,3,294,31.7,6.37,5.67,"","","","C6orf47","ENSG00000203623; ENSG00000204439; ENSG00000226103; ENSG00000226531; ENSG00000228177; ENSG00000228435; ENSG00000235360","","","",630.1,553.4,491,644.5,723.6,993.3,0.7091132379097146,-0.4959120658343679,0.11265819056509771,0.9482372283705428,0.35692185298669227,0.4474268610076634,2307]
["O95881","Thioredoxin domain-containing protein 12 [OS=Homo sapiens]",30,5,11,5,172,19.2,5.4,26.41,"other biological processes","ER/Golgi","other molecular function","TXNDC12","ENSG00000117862","Glutathione metabolism; Metabolic pathways","","",1456.3,1379.4,1869.1,1593.5,1638,1454.6,1.003990525170184,0.005745654393776185,0.9711092979776611,0.012731887664336774,0.98267172351083,0.007591540640655463,7223]
["O95900","Mitochondrial mRNA pseudouridine synthase TRUB2 [OS=Homo sapiens]",12,4,9,3,331,36.7,8.98,19.47,"RNA metabolism OR transcription;other metabolic processes;other biological processes","mitochondrion;other cell component","other molecular function","TRUB2","ENSG00000167112","","","",248.9,270.5,261.5,292.1,270.8,240.2,0.9723571161748225,-0.040441827236665714,0.6736168666361939,0.1715870471091783,0.7890169356160163,0.10291367490762929,6240]
["O95905","Protein ecdysoneless homolog [OS=Homo sapiens]",15,6,10,6,644,72.7,4.87,14.3,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","ECD","ENSG00000122882","","","",496.3,527.2,504,683.1,740.1,818.3,0.6814633058219942,-0.5532921193445964,0.004104534482375163,2.386736091455615,0.07772031743958567,1.109465434243397,386]
["O95983-1","methyl-CpG-binding domain protein 3 [OS=Homo sapiens]",6,2,3,2,291,32.8,5.34,7.15,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MBD3","ENSG00000071655; ENSPTRG00000010209","","Potential therapeutics for SARS; HDACs deacetylate histones; Regulation of PTEN gene transcription; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation","Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome",298.9,292.7,358.2,424.9,477.5,172.1,0.8839460214053046,-0.17796982145680876,0.6889958829125731,0.1617833732065878,0.7992177286475157,0.09733489093774167,6301]
["O95985","DNA topoisomerase 3-beta-1 [OS=Homo sapiens]",14,8,10,8,862,96.6,8.12,22.94,"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TOP3B","ENSG00000100038","Homologous recombination; Fanconi anemia pathway","","",533.2,508.8,488.4,477.9,512.6,783.3,0.862780471304544,-0.21293457285230102,0.45170741989069896,0.34514277551980904,0.6358878143261015,0.1966194974281488,5192]
["O95989","Diphosphoinositol polyphosphate phosphohydrolase 1 [OS=Homo sapiens]",33,5,11,5,172,19.5,6.34,27.02,"cell-cell signaling;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","NUDT3","ENSG00000272325","","Synthesis of pyrophosphates in the cytosol","",1030.2,1121.1,1102.5,1091.1,987.9,1159,1.004879555281038,0.007022590546437019,0.9307597690029773,0.031162396848144452,0.9553325588600984,0.019845420733970394,7121]
["O95997","Securin [OS=Homo sapiens]",11,2,2,2,202,22,6.6,5.51,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","PTTG1","ENSG00000164611","Cell cycle; Oocyte meiosis; Human T-cell leukemia virus 1 infection","APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids","Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition",122.5,110.6,136.2,109.4,116.7,138.3,1.0134467618002192,0.0192703034035623,0.8930109198550977,0.04914323046888195,0.9304371793614981,0.031312943949287735,7015]
["O95999","B-cell lymphoma/leukemia 10 [OS=Homo sapiens]",3,1,1,1,233,26.2,5.74,2.09,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","BCL10","ENSG00000142867","NF-kappa B signaling pathway; C-type lectin receptor signaling pathway; T cell receptor signaling pathway; B cell receptor signaling pathway; Shigellosis; Tuberculosis","E3 ubiquitin ligases ubiquitinate target proteins; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling","B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Modulators of TCR signaling and T cell activation; T-cell receptor (TCR) signaling pathway",47.8,56.1,57.1,71.9,47.3,372.4,0.3275020341741253,-1.6104242273706821,0.35132098121621336,0.4542959129625138,0.5833269086118363,0.23408798929587,4402]
["O96000","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [OS=Homo sapiens]",26,4,6,4,172,20.8,8.48,9.51,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity","NDUFB10","ENSG00000140990","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Modulators of TCR signaling and T cell activation; Oxidative phosphorylation",222.5,238.9,316.7,345.3,311.7,298.7,0.8141676258240031,-0.29660223891146575,0.13985470379330903,0.8543229222340054,0.3934557467379891,0.40510410708704153,2598]
["O96005-1","Cleft lip and palate transmembrane protein 1 [OS=Homo sapiens]",33,14,54,14,669,76,6.3,171.56,"developmental processes;other biological processes","plasma membrane;other membranes;other cell component","","CLPTM1","ENSG00000104853","","","",3767.1,3841.5,3742,3384.4,3465.6,5415.3,0.9254237564511264,-0.11181396024359583,0.6701822793757801,0.173807059746137,0.7875180514401249,0.10373948255298274,6220]
["O96006","zinc finger BED domain-containing protein 1 [OS=Homo sapiens]",1,1,1,1,694,78.1,6.1,2.51,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","ZBED1","ENSG00000214717","","SUMOylation of chromatin organization proteins","",30,30.8,30.2,52.4,46.8,30.5,0.7016191210485737,-0.5112400291656407,0.12120030012866172,0.9164963047236908,0.36956737323337024,0.43230637687337176,2397]
["O96007","molybdopterin synthase catalytic subunit [OS=Homo sapiens]",20,4,5,4,188,20.9,5.44,12.16,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","MOCS2","ENSG00000164172","Folate biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Sulfur relay system","Molybdenum cofactor biosynthesis","",442.5,447.9,383.5,500.4,472.2,245.9,1.045465736561346,0.06414578071941694,0.8351129449615418,0.07825478432906015,0.8964371441803362,0.047480156623430185,6809]
["O96008","Mitochondrial import receptor subunit TOM40 homolog [OS=Homo sapiens]",50,14,97,14,361,37.9,7.25,383.07,"cell organization and biogenesis;transport","other membranes;cytosol;mitochondrion;other cell component","transporter activity","TOMM40","ENSG00000130204","Amyotrophic lateral sclerosis; Pathways of neurodegeneration","Mitochondrial protein import; PINK1-PRKN Mediated Mitophagy","IL-18 signaling pathway",5987.8,6511,6778.5,5441.5,5074.6,5515.4,1.202463899198453,0.2659935815386229,0.015885739730447605,1.7989925571433174,0.14604889520734785,0.8355017239158147,795]
["O96011-1","Peroxisomal membrane protein 11B [OS=Homo sapiens]",31,8,22,8,259,28.4,9.85,65.56,"cell organization and biogenesis;signal transduction","other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PEX11B","ENSG00000131779; ENSPPAG00000024465; ENSPTRG00000001203","Peroxisome","Class I peroxisomal membrane protein import","",2574,2748.1,2578.4,2543.1,2369.1,3112.4,0.9845350547067766,-0.02248552019651428,0.8669580398492218,0.06200192155830791,0.9152963040961956,0.038438291285771205,6923]
["O96013-1","serine/threonine-protein kinase PAK 4 [OS=Homo sapiens]",2,1,1,1,591,64,9.73,4.48,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;ER/Golgi;other cell component","kinase activity;other molecular function","PAK4","ENSG00000130669","ErbB signaling pathway; Ras signaling pathway; Axon guidance; Focal adhesion; T cell receptor signaling pathway; Regulation of actin cytoskeleton; Human immunodeficiency virus 1 infection; MicroRNAs in cancer; Renal cell carcinoma","CDC42 GTPase cycle; RAC3 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; Activation of RAC1; RHOH GTPase cycle","Integrin-mediated cell adhesion; Focal adhesion; Ras signaling; Pancreatic adenocarcinoma pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; 22q11.2 copy number variation syndrome; Malignant pleural mesothelioma; Regulation of actin cytoskeleton; ErbB signaling pathway",143,155.6,120.7,151.7,172,269.7,0.7066059993259186,-0.5010220966338769,0.1997677373394084,0.699474649377503,0.4584308923747994,0.3387261241648992,3185]
["O96017-1","Serine/threonine-protein kinase Chk2 [OS=Homo sapiens]",25,10,20,10,543,60.9,5.91,64.49,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","CHEK2","ENSG00000183765","Cell cycle; p53 signaling pathway; Cellular senescence; Human T-cell leukemia virus 1 infection","Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Regulation of TP53 Activity through Methylation; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Stabilization of p53","miRNA regulation of DNA damage response; Cell cycle; ATM signaling in development and disease ; miRNA regulation of p53 pathway in prostate cancer; DNA damage response",1170.1,1208,1251.8,1221.8,1123,1203.8,1.0229104435552046,0.0326798417650533,0.5200433512833016,0.28396045167602324,0.6811822319945612,0.16673668872962905,5580]
["O96018","amyloid-beta A4 precursor protein-binding family A member 3 [OS=Homo sapiens]",14,5,7,5,575,61.4,4.94,15.3,"cell-cell signaling;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","enzyme regulator activity;other molecular function","APBA3","ENSG00000011132","","Neurexins and neuroligins","",578.9,587.5,571.5,629.5,584.2,574.5,0.9718711553517504,-0.04116303193714281,0.3939514635344256,0.4045572817724829,0.6040258542003601,0.21894447181555196,4767]
["O96019-1","Actin-like protein 6A [OS=Homo sapiens]",37,12,55,12,429,47.4,5.6,163.76,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;nucleus","other molecular function","ACTL6A","ENSCANG00000034249; ENSCATG00000017467; ENSCCAG00000029449; ENSCJAG00000013036; ENSCSAG00000013017; ENSG00000136518; ENSGGOG00000015710; ENSMFAG00000030153; ENSMMUG00000009742; ENSPANG00000024431; ENSPPAG00000031814; ENSPTRG00000023973; ENSRBIG00000036584; ENSRROG00000035215","Thermogenesis; Hepatocellular carcinoma","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines; UCH proteinases; HATs acetylate histones; DNA Damage Recognition in GG-NER","Gastric cancer network 1; Tumor suppressor activity of SMARCB1; Thermogenesis",8410.2,8127.7,8618.4,9685.1,10079.6,8348.3,0.8948280155088394,-0.16031766951071735,0.1436093114186648,0.8428174001588873,0.39668951517725665,0.40154927812639646,2646]
["O96028-1","Histone-lysine N-methyltransferase NSD2 [OS=Homo sapiens]",13,14,20,14,1365,152.2,8.69,51.59,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NSD2","ENSG00000109685","Lysine degradation; Metabolic pathways; Transcriptional misregulation in cancer","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; PKMTs methylate histone lysines; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)","",1191.8,1076,1155.4,1394.4,1516.1,1245.2,0.8237360733450443,-0.2797459257662284,0.0460828945130846,1.3364602502536669,0.23455423119508031,0.6297567282759754,1436]
["P00156","cytochrome b [OS=Homo sapiens]",2,1,1,1,380,42.7,8.05,2.39,"other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MT-CYB","ENSG00000198727","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly",226.3,252.8,272.7,164.5,181.3,105.5,1.6658541989807223,0.7362621368305293,0.01973864099640305,1.7046827517717746,0.1615562452885889,0.7916762487763482,893]
["P00167-1","Cytochrome b5 [OS=Homo sapiens]",49,5,12,5,134,15.3,4.96,47.76,"other metabolic processes;transport;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cell component","transporter activity;other molecular function","CYB5A","ENSG00000166347; ENSPTRG00000010111","","Vitamin C (ascorbate) metabolism","Oxidation by cytochrome P450",1518.9,1513.6,1761.6,2164.5,2172.5,1578.4,0.8104439260235995,-0.3032157246241675,0.15421748186937917,0.8118663925038453,0.41003112949555925,0.3871831704633408,2749]
["P00338-1","L-lactate dehydrogenase A chain [OS=Homo sapiens]",66,23,487,21,332,36.7,8.27,1452.1,"other metabolic processes;stress response;developmental processes;other biological processes","cytosol;other cell component","other molecular function","HEL-S-133P; LDHA","ENSG00000134333; ENSG00000288299","Glycolysis / Gluconeogenesis; Cysteine and methionine metabolism; Pyruvate metabolism; Propanoate metabolism; Metabolic pathways; HIF-1 signaling pathway; Glucagon signaling pathway; Central carbon metabolism in cancer","Pyruvate metabolism","Cori cycle; HIF1A and PPARG regulation of glycolysis; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling pathway; Amino acid metabolism; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - VitD3 signaling; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Orexin receptor pathway; CCL18 signaling pathway; Glycolysis and gluconeogenesis",56333.7,60322.5,55794.8,51375.8,45637.8,33748.3,1.3188168724987934,0.39924424959335614,0.061250042181121865,1.2128936078773538,0.265999143376007,0.5751197619692047,1683]
["P00367","Glutamate dehydrogenase 1, mitochondrial [OS=Homo sapiens]",47,24,162,24,558,61.4,7.8,471.84,"other metabolic processes;other biological processes","mitochondrion;ER/Golgi;other cell component","other molecular function","GLUD1","ENSG00000148672","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Nitrogen metabolism; Metabolic pathways; Carbon metabolism; Necroptosis; Proximal tubule bicarbonate reclamation","Transcriptional activation of mitochondrial biogenesis; Glutamate and glutamine metabolism","VEGFA-VEGFR2 signaling pathway; Amino acid metabolism; Metabolic reprogramming in colon cancer; 22q11.2 copy number variation syndrome; Amino acid metabolism pathway excerpt: histidine catabolism extension",17429.2,17226.4,17042.4,15392.9,15169.1,18358.2,1.0567822699007774,0.07967816717353472,0.42106999290702185,0.3756457069987326,0.6182403732738897,0.20884263738733405,4978]
["P00374","dihydrofolate reductase [OS=Homo sapiens]",41,7,22,7,187,21.4,7.42,58.4,"cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;mitochondrion","nucleic acid binding activity;other molecular function","DHFR","ENSG00000228716","One carbon pool by folate; Folate biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Antifolate resistance","G1/S-Specific Transcription; Metabolism of folate and pterines; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation","Fluoropyrimidine activity; Folate metabolism; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration and one-carbon metabolism; Ethanol effects on histone modifications; Nucleotide metabolism",2149.1,2199,2109.3,2935.6,2891.6,1746.5,0.8526083684328664,-0.23004487932589898,0.3941756632799822,0.4043101929167563,0.6033570519190345,0.2194256069525485,4775]
["P00387","NADH-cytochrome b5 reductase 3 [OS=Homo sapiens]",45,12,80,12,301,34.2,7.59,261.81,"other metabolic processes;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CYB5R3","ENSG00000100243","Amino sugar and nucleotide sugar metabolism","Neutrophil degranulation; Phase I - Functionalization of compounds; Vitamin C (ascorbate) metabolism","Oxidation by cytochrome P450",8029.3,8208.8,7345.9,7180,7109.5,8334.2,1.0424466378178634,0.05997353491605727,0.538246531119633,0.2690187604277568,0.6927353224077123,0.159432667227243,5679]
["P00390","Glutathione reductase, mitochondrial [OS=Homo sapiens]",47,18,83,18,522,56.2,8.5,280.8,"other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion","other molecular function","GSR","ENSG00000104687","Glutathione metabolism; Metabolic pathways; Thyroid hormone synthesis; Diabetic cardiomyopathy","","Glutathione metabolism; Selenium micronutrient network; Nuclear receptors meta-pathway; NRF2 pathway; Amino acid metabolism; One-carbon metabolism and related pathways; Oxidative stress response; Vitamin D-sensitive calcium signaling in depression; Sulfation biotransformation reaction; Metapathway biotransformation Phase I and II",9260.7,10012.5,9844.7,9536.3,8739.1,9030.8,1.0663475694164695,0.09267775230396381,0.1374120410952221,0.8619752094010308,0.39003674111261294,0.40889448089426766,2575]
["P00395","Cytochrome c oxidase subunit 1 [OS=Homo sapiens]",2,1,2,1,513,57,6.7,6.58,"other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MT-CO1","ENSG00000198804","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Electron transport chain: OXPHOS system in mitochondria; Effects of nitric oxide; Nonalcoholic fatty liver disease; Neuroinflammation; Mitochondrial complex IV assembly",329.1,331.3,342.3,362,315,707.4,0.7242848887604738,-0.4653708191826264,0.362090627538354,0.44118271644522,0.5883771446593663,0.2303442056608604,4498]
["P00403","Cytochrome c oxidase subunit 2 [OS=Homo sapiens]",31,6,33,6,227,25.5,4.82,81.38,"other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MT-CO2","ENSG00000198712","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Cytoprotection by HMOX1; Respiratory electron transport; TP53 Regulates Metabolic Genes","Electron transport chain: OXPHOS system in mitochondria; Endothelin pathways; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Neuroinflammation; Mitochondrial complex IV assembly; CCL18 signaling pathway",4993.3,5087,4732.5,4048.8,4186.1,5395.3,1.086763216974072,0.12003764146094711,0.42165967946219013,0.37503792572045,0.6183608742353828,0.20875799748759025,4984]
["P00439","phenylalanine-4-hydroxylase [OS=Homo sapiens]",2,1,1,1,452,51.8,6.6,0,"other metabolic processes","cytosol","other molecular function","PAH","ENSG00000171759","Phenylalanine metabolism; Phenylalanine, tyrosine and tryptophan biosynthesis; Folate biosynthesis; Metabolic pathways; Biosynthesis of amino acids","Phenylketonuria; Phenylalanine metabolism","Biogenic amine synthesis; Sudden infant death syndrome (SIDS) susceptibility pathways",59.6,59.4,41.3,53,42.1,26.4,1.3193415637860084,0.399818111661405,0.25816315029315656,0.5881057479969829,0.5159733293663334,0.28737274645105426,3657]
["P00441","Superoxide dismutase [Cu-Zn] [OS=Homo sapiens]",97,16,152,16,154,15.9,6.13,551.15,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","SOD1","ENSG00000142168","Peroxisome; Longevity regulating pathway; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Platelet degranulation ; Detoxification of Reactive Oxygen Species","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; AGE/RAGE pathway; Dopamine metabolism; Amyotrophic lateral sclerosis (ALS); Copper homeostasis; Physico-chemical features and toxicity-associated pathways; One-carbon metabolism and related pathways; Oxidative stress response; Extracellular vesicles in the crosstalk of cardiac cells",18889.9,18399.2,16906.2,18055.1,17869.9,29445.5,0.8290482710090944,-0.2704719903701859,0.39075121932379486,0.4080996581078297,0.6017700509982336,0.220569430105177,4746]
["P00450","Ceruloplasmin [OS=Homo sapiens]",1,1,1,1,1065,122.1,5.72,2.11,"transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi","other molecular function","CP","ENSG00000047457","Porphyrin and chlorophyll metabolism; Ferroptosis","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Metal ion SLC transporters; Iron uptake and transport; Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages); Defective CP causes aceruloplasminemia (ACERULOP)","Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway",66,43.6,51.1,39.3,43,64.3,{"$f":"AVERAGE(S898:U898)/AVERAGE(V898:X898)","v":1.0961800818553886},{"$f":"LOG(Y898,2)","v":0.13248482554128166},{"$f":"TTEST(V898:X898,S898:U898,2,2)","v":0.6688663483513313},0.17466065349117255,{"$f":"AA898*7309/AE898","v":0.786730630849675},0.10417394052615524,6214]
["P00488","Coagulation factor XIII A chain [OS=Homo sapiens]",1,1,2,1,732,83.2,6.09,2.76,"protein metabolism;other metabolic processes;stress response","non-structural extracellular;other cell component","other molecular function","F13A1","ENSG00000124491","Complement and coagulation cascades; Coronavirus disease","Platelet degranulation ; Interleukin-4 and Interleukin-13 signaling; Common Pathway of Fibrin Clot Formation","Complement system",83.9,88.2,74.3,66.3,70.2,52.8,1.301637612255679,0.3803278449911963,0.04650159941469194,{"$f":"-LOG10(AA899)","v":1.332532109367482},0.23537409288225997,{"$f":"-LOG10(AC899)","v":0.6282413407171293},1444]
["P00491","purine nucleoside phosphorylase [OS=Homo sapiens]",66,15,60,15,289,32.1,6.95,220.04,"other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","PNP","ENSG00000198805","Purine metabolism; Pyrimidine metabolism; Nicotinate and nicotinamide metabolism; Metabolic pathways","Neutrophil degranulation; Purine catabolism; Purine salvage","VEGFA-VEGFR2 signaling pathway",6130.4,7062.5,7001.4,5834.4,5076.4,5116.8,1.2599703012303778,0.3333897283501002,0.023346771957637177,1.6317731586909905,0.1730644586596046,0.7617921117482288,986]
["P00492","Hypoxanthine-guanine phosphoribosyltransferase [OS=Homo sapiens]",62,10,57,10,218,24.6,6.68,199.36,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","other molecular function","HPRT1","ENSG00000165704","Purine metabolism; Drug metabolism; Metabolic pathways","Purine salvage","Mesodermal commitment pathway; Nucleotide metabolism",6659.8,6393.1,6249.8,6218.4,6605.2,3693.7,1.168635309645039,0.22482478525662658,0.37032171963817856,0.4314208155163512,0.592271651823949,0.22747905370222846,4570]
["P00505","Aspartate aminotransferase, mitochondrial [OS=Homo sapiens]",51,22,164,22,430,47.5,9.01,475.51,"other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion;other cell component","other molecular function","GOT2","ENSG00000125166","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Cysteine and methionine metabolism; Arginine and proline metabolism; Tyrosine metabolism; Phenylalanine metabolism; Phenylalanine, tyrosine and tryptophan biosynthesis; Metabolic pathways; Carbon metabolism; 2-Oxocarboxylic acid metabolism; Biosynthesis of amino acids; Fat digestion and absorption","Gluconeogenesis; Glyoxylate metabolism and glycine degradation; Aspartate and asparagine metabolism; Glutamate and glutamine metabolism; Degradation of cysteine and homocysteine","Alanine and aspartate metabolism; Amino acid metabolism; Metabolic reprogramming in colon cancer; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis and gluconeogenesis",24702.8,23968.6,24826.1,21795,20893.5,16135.4,1.2494496284673406,0.321292740380031,0.0511579620993638,1.2910867641665833,0.24729731811127648,0.6067805934477982,1512]
["P00519","Tyrosine-protein kinase ABL1 [OS=Homo sapiens]",1,1,1,1,1130,122.8,8.66,0,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;kinase activity;other molecular function","ABL1","ENSG00000097007","ErbB signaling pathway; Ras signaling pathway; Cell cycle; Axon guidance; Neurotrophin signaling pathway; Pathogenic Escherichia coli infection; Pathways in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chronic myeloid leukemia; Viral myocarditis","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Factors involved in megakaryocyte development and platelet production; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RHO GTPases Activate WASPs and WAVEs; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Myogenesis; Cyclin D associated events in G1; RUNX2 regulates osteoblast differentiation; HDR through Single Strand Annealing (SSA); Role of ABL in ROBO-SLIT signaling","miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; TP53 network; Cell cycle; Integrated breast cancer pathway; Microtubule cytoskeleton regulation; Pathogenic Escherichia coli infection; Retinoblastoma gene in cancer; ATM signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Imatinib and chronic myeloid leukemia; VEGFA-VEGFR2 signaling pathway; Ras signaling; Acute viral myocarditis; EGF/EGFR signaling pathway; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)",28.3,20.4,21.1,32.6,41,44.8,0.5895270270270272,-0.7623701394192972,0.021179957500105907,1.674074915686891,0.16627745367161556,0.7791666347842606,931]
["P00558","phosphoglycerate kinase 1 [OS=Homo sapiens]",76,29,692,24,417,44.6,8.1,2197.3,"protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;other membranes;cytosol","kinase activity;other molecular function","PGK1","ENSG00000102144","Glycolysis / Gluconeogenesis; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; HIF-1 signaling pathway","Glycolysis; Gluconeogenesis; Manipulation of host energy metabolism","Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Glycolysis and gluconeogenesis",105936.9,105549.9,97969.9,96243.4,92534.9,93015.5,1.0981671704629412,0.1350976878952181,0.031570685130042984,1.5007159931800533,0.19789891733746498,0.7035565817190756,1166]
["P00568","Adenylate kinase isoenzyme 1 [OS=Homo sapiens]",39,6,16,6,194,21.6,8.63,37.83,"other metabolic processes","cytosol;cytoskeleton;other cell component","kinase activity;other molecular function","AK1","ENSG00000106992","Purine metabolism; Thiamine metabolism; Metabolic pathways; Biosynthesis of cofactors","Interconversion of nucleotide di- and triphosphates","",1217.5,1124.8,1184.9,1145.7,1171.7,983.2,1.0686541840877415,0.09579507324926338,0.3093609278767669,0.5095345383388071,0.5577501287250344,0.25356032081182406,4054]
["P00734","Prothrombin [OS=Homo sapiens]",6,3,3,3,622,70,5.9,10.7,"protein metabolism;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi","signal transduction activity or receptor binding;other molecular function","F2","ENSG00000180210","Phospholipase D signaling pathway; Neuroactive ligand-receptor interaction; Complement and coagulation cascades; Platelet activation; Regulation of actin cytoskeleton; Pathogenic Escherichia coli infection; Coronavirus disease; Pathways in cancer","Cell surface interactions at the vascular wall; Regulation of Complement cascade; G alpha (q) signalling events; Peptide ligand-binding receptors; Thrombin signalling through proteinase activated receptors (PARs); Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Intrinsic Pathway of Fibrin Clot Formation; Common Pathway of Fibrin Clot Formation; Defective F8 cleavage by thrombin; Gamma-carboxylation of protein precursors; Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus; Removal of aminoterminal propeptides from gamma-carboxylated proteins; Platelet Aggregation (Plug Formation); Defective factor XII causes hereditary angioedema","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Blood clotting cascade; IL1 and megakaryocytes in obesity; Regulation of actin cytoskeleton; Complement and coagulation cascades",223,226.5,223.6,230,200.1,159.6,1.1414278446667796,0.19083966251344933,0.2451793712320533,0.6105160730482767,0.5042251053278215,0.29737553463358646,3554]
["P00747","Plasminogen [OS=Homo sapiens]",4,3,9,3,810,90.5,7.24,19.13,"cell organization and biogenesis;protein metabolism;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","PLG","ENSG00000122194","Neuroactive ligand-receptor interaction; Complement and coagulation cascades; Staphylococcus aureus infection; Influenza A","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Signaling by PDGF; Platelet degranulation ; Activation of Matrix Metalloproteinases; Dissolution of Fibrin Clot","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Blood clotting cascade; Complement system; Fibrin complement receptor 3 signaling pathway; Complement and coagulation cascades",1447.2,1423.8,1303.9,1165.8,1215.3,1320,1.128015995244657,0.173787525269094,0.06777579377639179,1.168925387348538,0.28290878167427047,0.548353571548011,1751]
["P00813","adenosine deaminase [OS=Homo sapiens]",69,19,119,19,363,40.7,5.95,352.3,"cell adhesion;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","ADA","ENSG00000196839","Purine metabolism; Metabolic pathways; Primary immunodeficiency","Purine salvage","",10401.2,10811.5,10811.2,10040.6,9749.2,8942.4,1.1145648436249225,0.15648055276166065,0.03678500089411291,1.4343292290653236,0.21037681653761442,0.6770021210037319,1278]
["P00846","ATP synthase subunit A [OS=Homo sapiens]",4,1,5,1,226,24.8,10.1,16.69,"other metabolic processes;stress response;transport;other biological processes","other membranes;mitochondrion","transporter activity","MT-ATP6","ENSG00000198899","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation",854.5,792.1,903.6,723.5,859.9,969,0.9991380661338347,-0.001244043933142405,0.9929489392197239,0.003073083816072076,0.9960834198129237,1.7042888379962204E-3,7286]
["P00918","Carbonic anhydrase 2 [OS=Homo sapiens]",26,5,6,5,260,29.2,7.4,18.9,"other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","CA2","ENSG00000104267","Nitrogen metabolism; Metabolic pathways; Proximal tubule bicarbonate reclamation; Collecting duct acid secretion; Gastric acid secretion; Pancreatic secretion; Bile secretion","Reversible hydration of carbon dioxide; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide","Proximal tubule transport",269.7,302.2,280.9,295.9,269.3,1146.1,0.498334599427336,-1.0048133509093773,0.3767819488608055,0.42390991187154786,0.5942812395821381,0.22600797944153164,4634]
["P00966","Argininosuccinate synthase [OS=Homo sapiens]",5,3,3,3,412,46.5,8.02,6.49,"other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","ASS1","ENSG00000130707","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Metabolic pathways; Biosynthesis of amino acids; Fluid shear stress and atherosclerosis","Urea cycle","Alanine and aspartate metabolism; Amino acid metabolism",399.3,425.1,434.2,416.4,386.2,712.9,0.830484988452656,-0.26797400409963984,0.4595565485507291,0.33766104094272154,0.640156053622504,0.19371414325708755,5247]
["P00973-1","2'-5'-oligoadenylate synthase 1 [OS=Homo sapiens]",18,6,13,6,400,46,8.22,35.48,"cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component","nucleic acid binding activity;other molecular function","OAS1","ENSG00000089127","NOD-like receptor signaling pathway; Hepatitis C; Measles; Influenza A; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease","OAS antiviral response; Interferon gamma signaling; Interferon alpha/beta signaling","Immune response to tuberculosis; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; Type II interferon signaling (IFNG)",853.4,959.4,982,941.5,876.9,728.7,1.0972478504966432,0.13388944396755306,0.32946590789096414,0.48218951818937805,0.5717156507063288,0.242819918818854,4212]
["P01008","Antithrombin-III [OS=Homo sapiens]",2,1,2,1,464,52.6,6.71,2.3,"stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi","enzyme regulator activity;other molecular function","SERPINC1","ENSG00000117601","Complement and coagulation cascades","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Intrinsic Pathway of Fibrin Clot Formation; Common Pathway of Fibrin Clot Formation","Complement and coagulation cascades",291.6,266.2,258.8,228.8,251,486.2,0.8453416149068322,-0.24239362149798477,0.5806074989266672,0.23611735927003544,0.7235567279889191,0.1405274138376105,5865]
["P01023","alpha-2-macroglobulin [OS=Homo sapiens]",1,2,4,2,1474,163.2,6.46,8.32,"other biological processes","non-structural extracellular;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","A2M","ENSG00000175899","Complement and coagulation cascades","Platelet degranulation ; Intrinsic Pathway of Fibrin Clot Formation; Degradation of the extracellular matrix; HDL assembly","Complement system; Complement and coagulation cascades",832.6,965.4,1042.6,855.8,697,913.6,1.151719104768083,0.20378889770708788,0.2344884275466361,0.6298785856851611,0.49433975106384864,0.30597446545758483,3467]
["P01024","Complement C3 [OS=Homo sapiens]",1,1,1,1,1663,187,6.4,3.6,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity","C3","ENSG00000125730","Neuroactive ligand-receptor interaction; Phagosome; Complement and coagulation cascades; Neutrophil extracellular trap formation; Alcoholic liver disease; Shigellosis; Pertussis; Legionellosis; Leishmaniasis; Chagas disease; Staphylococcus aureus infection; Tuberculosis; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Coronavirus disease; Viral carcinogenesis; Systemic lupus erythematosus","Purinergic signaling in leishmaniasis infection; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; G alpha (i) signalling events; Neutrophil degranulation; Peptide ligand-binding receptors; Alternative complement activation; Activation of C3 and C5","Allograft Rejection; Complement system; TYROBP causal network in microglia; Cells and molecules involved in local acute inflammatory response ; 16p11.2 distal deletion syndrome; Complement system in neuronal development and plasticity; Acquired partial lipodystrophy / Barraquer-Simons syndrome; Complement activation; Complement and coagulation cascades",90,100.5,89.7,75.1,71,60.7,1.3549323017408121,0.43822077011588323,0.01171543484541908,1.9312415869252237,0.12799419026183567,0.8928097428090739,669]
["P01111","GTPase NRas [OS=Homo sapiens]",61,8,33,4,189,21.2,5.17,92.25,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi","other molecular function","NRAS","ENSG00000213281","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; Chemokine signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Mitophagy; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Apelin signaling pathway; Gap junction; Signaling pathways regulating pluripotency of stem cells; C-type lectin receptor signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Thermogenesis; Long-term potentiation; Neurotrophin signaling pathway; Cholinergic synapse; Serotonergic synapse; Long-term depression; Regulation of actin cytoskeleton; Insulin signaling pathway; GnRH signaling pathway; Estrogen signaling pathway; Melanogenesis; Prolactin signaling pathway; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Relaxin signaling pathway; GnRH secretion; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Alzheimer disease; Pathways of neurodegeneration; Alcoholism; Hepatitis C; Hepatitis B; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Endometrial cancer; Glioma; Prostate cancer; Thyroid cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis","Neutrophil degranulation; Tie2 Signaling; FCERI mediated MAPK activation; Regulation of RAS by GAPs; Signaling by BRAF and RAF1 fusions; Signaling by SCF-KIT; Downstream signal transduction; DAP12 signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; GRB2 events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; GRB2 events in EGFR signaling; SHC1 events in EGFR signaling; NCAM signaling for neurite out-growth; Signaling by FGFR1 in disease; p38MAPK events; SHC-mediated cascade:FGFR1; FRS-mediated FGFR1 signaling; SHC-mediated cascade:FGFR2; FRS-mediated FGFR2 signaling; Signaling by FGFR2 in disease; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ; SHC-mediated cascade:FGFR3; FRS-mediated FGFR3 signaling; FRS-mediated FGFR4 signaling; SHC-mediated cascade:FGFR4; Signaling by FGFR3 point mutants in cancer; FLT3 Signaling; Activated NTRK2 signals through FRS2 and FRS3; RAS processing; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; CD209 (DC-SIGN) signaling; Activation of RAS in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; SOS-mediated signalling; SHC-related events triggered by IGF1R; Signaling by FGFR4 in disease; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants; RAS signaling downstream of NF1 loss-of-function variants; Insulin receptor signalling cascade; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; MET activates RAS signaling; Signaling by FGFR3 fusions in cancer; Activated NTRK2 signals through RAS; Activated NTRK3 signals through RAS; Constitutive Signaling by Overexpressed ERBB2; RAS GTPase cycle mutants; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants","Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; RalA downstream regulated genes; TNF-alpha signaling pathway; Aryl hydrocarbon receptor Netpath; Bladder cancer; Extracellular vesicle-mediated signaling in recipient cells; RAC1/PAK1/p38/MMP2 pathway; G protein signaling pathways; BDNF-TrkB signaling; MAPK signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MAPK cascade; Ras signaling; Non-small cell lung cancer; Breast cancer pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Synaptic signaling pathways associated with autism spectrum disorder; Hippo-Merlin signaling dysregulation; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; EGFR tyrosine kinase inhibitor resistance; Kisspeptin/kisspeptin receptor system in the ovary; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; ErbB signaling pathway; DNA damage response (only ATM dependent); Serotonin receptor 2 and ELK-SRF/GATA4 signaling",1760.2,1645.7,1781.1,1441.5,1523.1,1400.7,1.1882344856023639,0.24881956495550053,0.007779398476648221,2.109053982492569,0.10608138706310047,0.9743608103013658,536]
["P01116-2","Isoform 2B of GTPase KRas [OS=Homo sapiens]",61,8,40,4,188,21.4,8.12,99.1,"","","","KRAS","","","","",1430.2,1481.2,1423,1359.6,1405.8,1656.1,0.9803008028949451,-0.028703590295046294,0.772628639747356,0.11202919749367077,0.8545918171781818,0.06824126992202356,6608]
["P01130","Low-density lipoprotein receptor [OS=Homo sapiens]",20,16,21,16,860,95.3,5.05,57.91,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","LDLR","ENSG00000130164","Endocytosis; Ovarian steroidogenesis; Aldosterone synthesis and secretion; Cortisol synthesis and secretion; Cushing syndrome; Bile secretion; Cholesterol metabolism; Toxoplasmosis; Hepatitis C; Lipid and atherosclerosis","Retinoid metabolism and transport; Cargo recognition for clathrin-mediated endocytosis; LDL clearance; Chylomicron clearance","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Oncostatin M signaling pathway; PCSK9-mediated LDL receptor degradation; Evolocumab mechanism to reduce LDL cholesterol; Lipid particles composition; Wnt signaling pathway and pluripotency; Statin inhibition of cholesterol production; Bile acids synthesis and enterohepatic circulation ; Metabolic pathway of LDL, HDL and TG, including diseases; Orexin receptor pathway; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5; DNA damage response (only ATM dependent)",2166.7,2082,2242.6,3481.6,4009.7,2908,0.6242054753685344,-0.6799070826280182,0.015450259482596033,1.8110642223289013,0.14459148086849477,0.8398572943222287,781]
["P01591","Immunoglobulin J chain [OS=Homo sapiens]",38,3,20,3,159,18.1,5.24,60.44,"cell organization and biogenesis;stress response;other biological processes","non-structural extracellular","signal transduction activity or receptor binding;other molecular function","JCHAIN","ENSG00000132465","","Cell surface interactions at the vascular wall; Scavenging of heme from plasma","",952.1,901.7,853.3,1289,1348.9,1275,0.6918398119042144,-0.5314900589386526,3.8369027502227861E-4,3.4160192082493896,0.028616247144263612,1.5433873220579117,98]
["P01834","immunoglobulin kappa constant [OS=Homo sapiens]",19,1,1,1,107,11.8,6.52,5.11,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","IGKC","","","Initial triggering of complement; Classical antibody-mediated complement activation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; Scavenging of heme from plasma; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Regulation of Complement cascade; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers","",20.4,19.1,10.7,16.3,26.6,23.5,0.7560240963855421,-0.40349587739615284,0.2781863811872907,0.5556641350196858,0.531711365088365,0.27432405673977533,3824]
["P01854","immunoglobulin heavy constant epsilon [OS=Homo sapiens]",4,1,1,1,428,47,8.06,2.5,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","IGHE","ENSG00000211891; ENSG00000276192","","FCERI mediated NF-kB activation; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; Interleukin-4 and Interleukin-13 signaling","",162.7,143.2,164,170.6,157.6,79.9,1.1514334721881891,0.20343105714301507,0.5181353371956818,0.2855567875126296,0.680512341341103,0.16716399429938378,5565]
["P01857","Immunoglobulin heavy constant gamma 1 [OS=Homo sapiens]",11,2,6,2,330,36.1,8.19,24.71,"cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","IGHG1","ENSG00000211896; ENSG00000277633","","Initial triggering of complement; Classical antibody-mediated complement activation; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Regulation of Complement cascade; Interleukin-4 and Interleukin-13 signaling","Interactions of natural killer cells in pancreatic cancer",383.8,350.7,387.5,438.1,478.4,278.6,0.9388335704125179,-0.09105866482671927,0.7148521217987244,0.14578378942839781,0.8149827106889528,0.08885160442815672,6411]
["P01889","HLA class I histocompatibility antigen, B-7 alpha chain [OS=Homo sapiens]",43,13,95,3,362,40.4,5.85,312.16,"stress response;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","HLA-B","ENSG00000234745","Endocytosis; Phagosome; Cellular senescence; Cell adhesion molecules; Antigen processing and presentation; Natural killer cell mediated cytotoxicity; Type I diabetes mellitus; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Viral carcinogenesis; Autoimmune thyroid disease; Allograft rejection; Graft-versus-host disease; Viral myocarditis","DAP12 interactions; Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ER-Phagosome pathway; Interferon gamma signaling; Interferon alpha/beta signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Endosomal/Vacuolar pathway","Proteasome degradation; Allograft Rejection; Ebola virus pathway in host; Type II interferon signaling (IFNG)",3682.6,3441.3,3378.4,2784,3336.8,5387.5,0.9125848300791602,-0.1319694228608285,0.6956885979983105,0.15758511446180573,0.804173329553954,0.09465033439105106,6323]
["P01903","HLA class II histocompatibility antigen, DR alpha chain [OS=Homo sapiens]",26,5,14,5,254,28.6,5,51.51,"other biological processes","plasma membrane;other membranes;other cytoplasmic organelle","","HLA-DRA","","","","",1418.1,1272.5,1291.6,1142.2,1217.1,1160.1,1.1314996874467236,0.17823618609033418,0.038888390756505326,1.410180028054132,0.21631297415471645,0.6649174313939208,1314]
["P01911","HLA class II histocompatibility antigen, DRB1-15 beta chain [OS=Homo sapiens]",23,6,13,2,266,29.9,7.74,31.26,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","HLA-DRB1","ENSG00000196126","Phagosome; Cell adhesion molecules; Antigen processing and presentation; Hematopoietic cell lineage; Th1 and Th2 cell differentiation; Th17 cell differentiation; Intestinal immune network for IgA production; Type I diabetes mellitus; Leishmaniasis; Toxoplasmosis; Staphylococcus aureus infection; Tuberculosis; Influenza A; Human T-cell leukemia virus 1 infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Asthma; Autoimmune thyroid disease; Inflammatory bowel disease; Systemic lupus erythematosus; Rheumatoid arthritis; Allograft rejection; Graft-versus-host disease; Viral myocarditis","Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling","Allograft Rejection; Vitamin D receptor pathway; Ebola virus pathway in host; Cancer immunotherapy by PD-1 blockade; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Genes associated with the development of rheumatoid arthritis; Network map of SARS-CoV-2 signaling pathway; Cytokines and inflammatory response",436.3,443.9,424.1,399.2,444.3,699.3,0.8454109411459685,-0.2422753113158078,0.4435542584389298,0.3530532468597503,0.6315873904013517,0.19956654923654005,5133]
["P02042","Hemoglobin subunit delta [OS=Homo sapiens]",13,2,25,1,147,16,8.05,63.89,"other metabolic processes;transport;other biological processes","cytosol;other cell component","other molecular function","HBD","ENSG00000223609","","Factors involved in megakaryocyte development and platelet production","VEGFA-VEGFR2 signaling pathway",962.3,1120,943.2,710.8,844.7,685.9,1.349826001606139,0.4327734496476189,0.02484955433343479,1.6046813957542165,0.17911774420421586,0.7468613888675608,1014]
["P02533","Keratin, type I cytoskeletal 14 [OS=Homo sapiens]",42,19,57,6,472,51.5,5.16,160.3,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KRT14","ENSG00000186847","Estrogen signaling pathway; Staphylococcus aureus infection","Formation of the cornified envelope; Type I hemidesmosome assembly","Corticotropin-releasing hormone signaling pathway",2854.8,3088.2,2664.1,2558.6,3424,8519.1,0.5935235179323802,-0.7526228981588524,0.35117723592001504,0.4544736437760218,0.5832207265029289,0.2341670504549939,4401]
["P02538","Keratin, type II cytoskeletal 6A [OS=Homo sapiens]",33,23,73,4,564,60,8,179.44,"cell organization and biogenesis;stress response;other biological processes","cytosol;cytoskeleton","cytoskeletal activity","KRT6A","ENSG00000205420","","Formation of the cornified envelope","Ectoderm differentiation; Ectoderm differentiation",2822.6,2573.7,2921.2,2384.4,3413.9,15991.8,0.3817100426340403,-1.38945095112212,0.36273433721800524,0.44041133121730974,0.5885072743010877,0.23024816464841857,4505]
["P02545","Prelamin-A/C [OS=Homo sapiens]",66,46,249,43,664,74.1,7.02,742.27,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","LMNA","ENSG00000160789","Apoptosis; Hypertrophic cardiomyopathy; Arrhythmogenic right ventricular cardiomyopathy; Dilated cardiomyopathy","Signaling by BRAF and RAF1 fusions; XBP1(S) activates chaperone genes","Arrhythmogenic right ventricular cardiomyopathy; Adipogenesis; Fas ligand pathway and stress induction of heat shock proteins; Lamin A-processing pathway; Nephrotic syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome",27286,27346.3,27295.6,26818.7,26635.8,27545.9,1.0114505607379718,0.016425803315561815,0.3292984391856162,0.48241032775963977,0.5718323335727414,0.24273129162368917,4209]
["P02647","Apolipoprotein A-I [OS=Homo sapiens]",8,2,13,1,267,30.8,5.76,31.99,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;other molecular function","APOA1","ENSG00000118137","PPAR signaling pathway; Fat digestion and absorption; Vitamin digestion and absorption; Cholesterol metabolism; African trypanosomiasis; Lipid and atherosclerosis","PPARA activates gene expression; Platelet degranulation ; Scavenging of heme from plasma; Amyloid fiber formation; Scavenging by Class B Receptors; Heme signaling; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Retinoid metabolism and transport; HDL clearance; Defective ABCA1 causes TGD; HDL assembly; Scavenging by Class A Receptors; ABC transporters in lipid homeostasis; Chylomicron assembly; Chylomicron remodeling; HDL remodeling","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Complement system; PPAR-alpha pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Statin inhibition of cholesterol production; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5",429.6,409.8,403.1,335.9,388.3,191,1.3576267482517483,0.44108689455862155,0.14083310830712223,0.8512952353585892,0.3943866623052707,0.40407778081289714,2610]
["P02649","Apolipoprotein E [OS=Homo sapiens]",5,2,4,2,317,36.1,5.73,10.12,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;cytoskeletal activity;other molecular function","APOE","ENSG00000130203","Cholesterol metabolism; Alzheimer disease","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Amyloid fiber formation; Retinoid metabolism and transport; Nuclear signaling by ERBB4; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Chylomicron clearance; Scavenging by Class A Receptors; Chylomicron assembly; Chylomicron remodeling; HDL remodeling; Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors","Vitamin B12 metabolism; Alzheimer's disease and miRNA effects; Apoptosis-related network due to altered Notch3 in ovarian cancer; ApoE and miR-146 in inflammation and atherosclerosis; Statin inhibition of cholesterol production; Familial hyperlipidemia type 3; Alzheimer's disease",478.7,421.3,406.5,381.4,406.5,448.1,1.0570388349514563,0.08002838141564626,0.46858135354153485,0.329214997461508,0.6459564528545979,0.18979675897460965,5302]
["P02656","Apolipoprotein C-III [OS=Homo sapiens]",16,1,2,1,99,10.8,5.41,10.27,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","non-structural extracellular;other cytoplasmic organelle","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","APOC3","ENSG00000110245","PPAR signaling pathway; Cholesterol metabolism","Retinoid metabolism and transport; Chylomicron assembly; Chylomicron remodeling; HDL remodeling","PPAR-alpha pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Statin inhibition of cholesterol production",86.4,96,81.7,70.3,76.5,148.2,0.8952542372881358,-0.1596306529694727,0.7053035588418307,0.15162392477375966,0.8099078886999121,0.09156437087946089,6365]
["P02671-1","Fibrinogen alpha chain [OS=Homo sapiens]",1,1,1,1,866,94.9,6.01,2.72,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGA","ENSG00000171560","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Coronavirus disease","ER-Phagosome pathway; Signaling by BRAF and RAF1 fusions; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Amyloid fiber formation; Integrin cell surface interactions; Platelet degranulation ; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Common Pathway of Fibrin Clot Formation; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway",102.5,154.5,164.2,152.1,110.1,101.3,1.1587345254470427,0.21255007221876027,0.48051004881111997,0.3182975255863088,0.6546221708780011,0.18400929000430571,5365]
["P02675","Fibrinogen beta chain [OS=Homo sapiens]",7,4,12,4,491,55.9,8.27,24.85,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGB","ENSG00000171564","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Coronavirus disease","ER-Phagosome pathway; Platelet degranulation ; Common Pathway of Fibrin Clot Formation; Integrin cell surface interactions; Signaling by BRAF and RAF1 fusions; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway; Complement and coagulation cascades",1147,1726,1853.4,1798.2,1322.1,1446.4,1.0349705476602358,0.04958971328102759,0.847741582550491,0.07173651375279246,0.9033595607029508,0.04413935472730635,6859]
["P02679","Fibrinogen gamma chain [OS=Homo sapiens]",2,1,2,1,453,51.5,5.62,5.09,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","FGG","ENSG00000171557","Complement and coagulation cascades; Platelet activation; Neutrophil extracellular trap formation; Staphylococcus aureus infection; Coronavirus disease","ER-Phagosome pathway; Platelet degranulation ; Integrin cell surface interactions; Signaling by BRAF and RAF1 fusions; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Common Pathway of Fibrin Clot Formation; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins","Selenium micronutrient network; Folate metabolism; Blood clotting cascade; Complement system; VEGFA-VEGFR2 signaling pathway; Fibrin complement receptor 3 signaling pathway; COVID-19, thrombosis and anticoagulation; Network map of SARS-CoV-2 signaling pathway",84,185.9,190.3,196.3,118.6,109,1.085633404104742,0.11853701716899442,0.7986245907488273,0.09765732141177931,0.8722574915993991,0.05935529181816323,6692]
["P02686-1","myelin basic protein [OS=Homo sapiens]",3,1,1,1,304,33.1,9.79,2,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","MBP","ENSG00000197971; ENSGGOG00000009590","","EGR2 and SOX10-mediated initiation of Schwann cell myelination","Neural crest differentiation; Glial cell differentiation; Spinal cord injury; Interleukin-1 (IL-1) structural pathway; MECP2 and associated Rett syndrome; MAPK cascade; Complement system in neuronal development and plasticity",32.6,28.5,31.5,36.9,28.5,66.2,0.7036474164133737,-0.5070753904750055,0.32120288490489357,0.4932205627313094,0.5662498518499438,0.2469918986051785,4146]
["P02749","Beta-2-glycoprotein 1 [OS=Homo sapiens]",4,2,5,2,345,38.3,7.97,7.37,"protein metabolism;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;other cell component","enzyme regulator activity;other molecular function","APOH","ENSG00000091583","Cholesterol metabolism","Platelet degranulation","",688.1,521.7,665.6,494.6,717.9,548.3,1.0650840527033167,0.0909672873838082,0.6768256520656546,0.16952318965661556,0.7913803696925084,0.10161472667544584,6251]
["P02751","fibronectin [OS=Homo sapiens]",12,20,36,20,2386,262.5,5.71,113.49,"","","","","","","","",1936.8,2766.6,2446.6,2711.6,2191.2,2600,0.9529775550461164,-0.06948585935129147,0.704704421841024,0.15199300340675953,0.8094742447329946,0.09179696475901084,6363]
["P02753","Retinol-binding protein 4 [OS=Homo sapiens]",4,1,1,1,201,23,6.07,1.83,"other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;other cell component","transporter activity;other molecular function","RBP4","ENSG00000138207","","Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision); Retinoid cycle disease events; Retinoid metabolism disease events","Sterol regulatory element-binding proteins (SREBP) signaling; Vitamin A and carotenoid metabolism",171.4,162.6,174.6,127,195.8,188,0.9956930305403288,-0.006227063012617733,0.9750557609417827,0.010970547402115383,0.98489255897229,0.006611143705918515,7236]
["P02760","Protein AMBP [OS=Homo sapiens]",2,1,2,1,352,39,6.25,1.84,"cell adhesion;protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","enzyme regulator activity;other molecular function","AMBP","ENSG00000106927","","Scavenging of heme from plasma","",403.8,430.7,419.3,404.6,452.5,286.5,1.096362364463099,0.13272470980462323,0.502804661512901,0.29860070461387267,0.6700089828619497,0.17391937464062965,5485]
["P02765","Alpha-2-HS-glycoprotein [OS=Homo sapiens]",5,3,23,3,367,39.3,5.72,66.88,"","","","","","","","",4601.1,2730.4,4399.6,3233.2,5121.5,1528.1,1.1870218966284858,0.24734654817776394,0.6333920493569817,0.19832739240405273,0.7640637875474797,0.11687038301660951,6059]
["P02766","Transthyretin [OS=Homo sapiens]",4,1,2,1,147,15.9,5.76,2.01,"other metabolic processes;transport;signal transduction","non-structural extracellular;other cytoplasmic organelle","signal transduction activity or receptor binding;other molecular function","TTR","ENSG00000118271","Thyroid hormone synthesis","Neutrophil degranulation; Amyloid fiber formation; Retinoid metabolism and transport; Non-integrin membrane-ECM interactions; The canonical retinoid cycle in rods (twilight vision); Retinoid cycle disease events","",136.2,128,139.2,147.9,165.1,106.3,0.9620796565704746,-0.05577174623342836,0.7803893536026549,0.10768866406372918,0.8601818406698545,0.06540973009176505,6631]
["P02768-1","Serum albumin [OS=Homo sapiens]",12,9,57,9,609,69.3,6.28,144.76,"stress response;other biological processes","non-structural extracellular;ER/Golgi;other cell component","nucleic acid binding activity;other molecular function","ALB","ENSG00000163631","Thyroid hormone synthesis","Cytoprotection by HMOX1; Scavenging of heme from plasma; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Recycling of bile acids and salts; Heme degradation; HDL remodeling; Heme biosynthesis","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Complement system; VEGFA-VEGFR2 signaling pathway",9906.5,8678,9661.6,9218.8,11913.2,8098.5,0.9663228477104394,-0.0494228220009333,0.7968435403034471,0.0986269436645454,0.8718756640835171,0.05954544425611811,6680]
["P02771","Alpha-fetoprotein [OS=Homo sapiens]",3,2,5,2,609,68.6,5.68,14.64,"other metabolic processes;developmental processes;signal transduction","non-structural extracellular;ER/Golgi;other cell component","other molecular function","AFP","ENSG00000081051","Hippo signaling pathway","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","",999.7,1046.4,996.3,1049.3,1271.3,2405.2,0.6437851792289138,-0.6353487304033423,0.25266927133960104,0.5974475720852922,0.5105777451537583,0.29193811896293903,3617]
["P02774","vitamin D-binding protein [OS=Homo sapiens]",8,2,7,2,474,52.9,5.54,29.89,"transport","non-structural extracellular","transporter activity;cytoskeletal activity;other molecular function","HEL-S-51","","","","",337.2,431.9,372.2,380,450.5,1837.1,0.42783775678512526,-1.2248642885811636,0.3446274972360667,0.46265007389476065,0.5793197739876751,0.2370816474250447,4348]
["P02786","Transferrin receptor protein 1 [OS=Homo sapiens]",34,25,82,25,760,84.8,6.61,240.32,"protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","TFRC","ENSG00000072274","HIF-1 signaling pathway; Endocytosis; Phagosome; Ferroptosis; Hematopoietic cell lineage","RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; RHOC GTPase cycle; RND2 GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RND1 GTPase cycle; Transferrin endocytosis and recycling; RHOH GTPase cycle","Iron metabolism in placenta; Ferroptosis; 3q29 copy number variation syndrome",9593.4,10097.7,10268.7,9305.5,8895.7,9027,1.1003224598027044,0.1379263810084295,0.01816924820154359,1.7406630423494203,0.1549580339615894,0.8097859023886455,857]
["P02787","Serotransferrin [OS=Homo sapiens]",2,1,2,1,698,77,7.12,2.06,"cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","TF","ENSG00000091513","HIF-1 signaling pathway; Ferroptosis; Mineral absorption","Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cargo recognition for clathrin-mediated endocytosis; Transferrin endocytosis and recycling","Iron metabolism in placenta; Pluripotent stem cell differentiation pathway; Ferroptosis; IL-18 signaling pathway; 3q29 copy number variation syndrome; Sudden infant death syndrome (SIDS) susceptibility pathways",183.6,183.5,169.1,147,169.1,386.6,0.7630567809876192,-0.3901376792412794,0.508851913071105,0.29340858837726946,0.6741342455386453,0.17125361045103643,5517]
["P02788","Lactotransferrin [OS=Homo sapiens]",1,1,1,1,710,78.1,8.12,2.05,"protein metabolism;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","LTF","ENSG00000012223","","Neutrophil degranulation; Amyloid fiber formation; Mtb iron assimilation by chelation; Metal sequestration by antimicrobial proteins","Male infertility",185.3,177.1,200.5,164,183.7,136.2,1.1632568712543916,0.21816970899101845,0.16222562596718756,0.7898805413882196,0.41971932750236246,0.377041031659704,2825]
["P02792","Ferritin light chain [OS=Homo sapiens]",62,11,90,11,175,20,5.78,266.59,"transport;other biological processes","non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component","other molecular function","FTL","ENSG00000087086","Ferroptosis; Necroptosis; Mineral absorption","Neutrophil degranulation; Scavenging by Class A Receptors; Golgi Associated Vesicle Biogenesis; Iron uptake and transport","Nuclear receptors meta-pathway; NRF2 pathway; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway",14664.5,14896.5,16241,10647.9,12880.8,14601.4,1.2012032488768716,0.26448028204916924,0.10929071073329578,0.9614167497494217,0.3494338603454326,0.4566350139247116,2286]
["P02794","Ferritin heavy chain [OS=Homo sapiens]",43,5,13,5,183,21.2,5.55,47.17,"transport;other biological processes","non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component","other molecular function","FTH1","ENSG00000167996","Ferroptosis; Necroptosis; Mineral absorption","Neutrophil degranulation; Scavenging by Class A Receptors; Golgi Associated Vesicle Biogenesis; Iron uptake and transport","Iron metabolism in placenta; Nuclear receptors meta-pathway; NRF2 pathway; Ferroptosis",659.4,851,908.5,780.4,734,2290,0.6358164230890547,-0.6533178132288185,0.4218795381816468,0.37481153806988604,0.6185591864733513,0.2086187388335876,4985]
["P03891","NADH-ubiquinone oxidoreductase chain 2 [OS=Homo sapiens]",5,2,8,2,347,38.9,9.83,14.21,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion;other cell component","signal transduction activity or receptor binding;transporter activity;other molecular function","MT-ND2","ENSG00000198763","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",757.1,772.7,816.6,654.9,639.3,481.9,1.3210967850909296,0.401736163977483,0.030652550432157644,1.5135333843582592,0.19583871600405614,0.7081014469312915,1144]
["P03897","NADH-ubiquinone oxidoreductase chain 3 [OS=Homo sapiens]",13,1,4,1,115,13.2,4.44,10.89,"other metabolic processes;stress response;transport;other biological processes","other membranes;mitochondrion","transporter activity","MT-ND3","ENSG00000198840","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",127.2,133,113,124,134.2,832.5,0.34216558173649947,-1.547233447729157,0.36555249872743634,0.4370502431374402,0.5898064488297643,0.22929048326629908,4530]
["P03905","NADH-ubiquinone oxidoreductase chain 4 [OS=Homo sapiens]",7,3,13,3,459,51.5,9.35,35.17,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","MT-ND4","ENSG00000198886","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",1225.3,1439.5,1409.4,1037.2,961,785.8,1.4634339080459773,0.549357591877582,0.012684835583113669,1.8967151575955206,0.1318825935661135,0.8798125207313715,703]
["P03923","NADH-ubiquinone oxidoreductase chain 6 [OS=Homo sapiens]",8,1,2,1,174,18.6,4.22,9.21,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","other membranes;mitochondrion","transporter activity","MT-ND6","ENSG00000198695","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",193.2,250.9,226.4,154,154.7,186.6,1.3537250151423381,0.4369347111574223,0.04247885773810537,1.3718271700035052,0.2253105741711264,0.6472184256911391,1378]
["P03928","ATP synthase protein 8 [OS=Homo sapiens]",13,1,2,1,68,8,9.91,5.52,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","MT-ATP8","ENSG00000228253","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome",857.6,878.3,1111.2,605.9,1450.1,69.7,1.3393705602860237,0.4215551626982187,0.5889723497259013,0.22990509340192364,0.7306176008395473,0.13630986968854397,5892]
["P04004","Vitronectin [OS=Homo sapiens]",9,2,18,2,478,54.3,5.8,74.16,"cell adhesion;transport;developmental processes;other biological processes","non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component","signal transduction activity or receptor binding;extracellular structural activity;other molecular function","VTN","ENSG00000109072","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Complement and coagulation cascades; Human papillomavirus infection; Proteoglycans in cancer","Regulation of Complement cascade; Integrin cell surface interactions; ECM proteoglycans; Syndecan interactions; Molecules associated with elastic fibres","Primary focal segmental glomerulosclerosis (FSGS); Complement system; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; Inflammatory response pathway; Complement system in neuronal development and plasticity; Senescence and autophagy in cancer",1370.1,1277.1,1225.2,1039.9,1138.2,1014.6,1.2128919096689321,0.2784509862927394,0.016208927706794732,1.790245714727393,0.1479039358414016,0.8300202689276576,801]
["P04040","catalase [OS=Homo sapiens]",49,20,80,20,527,59.7,7.39,257.61,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","CAT","ENSG00000121691","Tryptophan metabolism; Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism; FoxO signaling pathway; Peroxisome; Longevity regulating pathway; Longevity regulating pathway; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Chemical carcinogenesis","Neutrophil degranulation; Peroxisomal protein import; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Detoxification of Reactive Oxygen Species","Selenium micronutrient network; Folate metabolism; Amyotrophic lateral sclerosis (ALS); Oxidative stress response; Tryptophan metabolism; Male infertility; DNA damage response (only ATM dependent)",7587.6,7373.9,7612.2,6944.4,6996.2,5750.6,1.1463851872917852,0.19709187343674733,0.08097022097212216,1.091674675509021,0.308556488574161,0.5106653164596927,1918]
["P04049","RAF proto-oncogene serine/threonine-protein kinase [OS=Homo sapiens]",18,10,19,7,648,73,9.2,53.28,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","RAF1","ENSG00000132155","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; FoxO signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Cellular senescence; Vascular smooth muscle contraction; Axon guidance; VEGF signaling pathway; Apelin signaling pathway; Focal adhesion; Gap junction; Signaling pathways regulating pluripotency of stem cells; Neutrophil extracellular trap formation; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Long-term potentiation; Neurotrophin signaling pathway; Serotonergic synapse; Long-term depression; Regulation of actin cytoskeleton; Insulin signaling pathway; GnRH signaling pathway; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Melanogenesis; Prolactin signaling pathway; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Relaxin signaling pathway; Parathyroid hormone synthesis, secretion and action; GnRH secretion; Growth hormone synthesis, secretion and action; Alzheimer disease; Pathways of neurodegeneration; Alcoholism; Salmonella infection; Tuberculosis; Hepatitis C; Hepatitis B; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer","Signaling by BRAF and RAF1 fusions; Stimuli-sensing channels; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; CD209 (DC-SIGN) signaling; Rap1 signalling; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GP1b-IX-V activation signalling; Negative feedback regulation of MAPK pathway","IL-5 signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Endothelin pathways; Pilocytic astrocytoma; Glioblastoma signaling pathways; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Retinoblastoma gene in cancer; Aryl hydrocarbon receptor Netpath; Common pathways underlying drug addiction; Cardiac hypertrophic response; Bladder cancer; IL-3 signaling pathway; Extracellular vesicle-mediated signaling in recipient cells; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; Pathways affected in adenoid cystic carcinoma; TGF-beta signaling pathway; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; ERK pathway in Huntington's disease; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway; Fragile X syndrome; 22q11.2 copy number variation syndrome; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; Netrin-UNC5B signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Regucalcin in proximal tubule epithelial kidney cells; Kisspeptin/kisspeptin receptor system in the ovary; CAMKK2 pathway; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Angiotensin II receptor type 1 pathway; Malignant pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; EPO receptor signaling; Senescence and autophagy in cancer; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling",1707.7,1794.4,1731.2,1874.2,1826.1,2988.4,0.7824091377995723,-0.3540048751836874,0.27139184858417265,0.5664032007738415,0.5253185967430397,0.2795772245158999,3776]
["P04053","DNA nucleotidylexotransferase [OS=Homo sapiens]",3,1,1,1,509,58.5,8.43,2.25,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DNTT","ENSG00000107447","Non-homologous end-joining; Hematopoietic cell lineage","","",16.9,15.8,18.7,7.4,8.3,10.3,1.9769230769230774,0.9832567361654241,0.002152809644175914,2.6669943696836365,0.060518791112622136,1.2181097557704816,260]
["P04062","glucosylceramidase [OS=Homo sapiens]",21,10,25,10,536,59.7,7.61,73.39,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","signal transduction activity or receptor binding;other molecular function","GBA","ENSG00000177628","Other glycan degradation; Sphingolipid metabolism; Metabolic pathways; Lysosome","Glycosphingolipid metabolism; Association of TriC/CCT with target proteins during biosynthesis","Sphingolipid pathway",3262.4,3186.6,3319.2,2972.1,3108.7,4172.5,0.9526884027581366,-0.06992366805897511,0.6933683739102692,0.15903597137516934,0.8021255848227536,0.09575763106032652,6318]
["P04066","tissue alpha-L-fucosidase [OS=Homo sapiens]",21,9,25,9,466,53.7,6.84,71.08,"other metabolic processes","non-structural extracellular;other cytoplasmic organelle;other cell component","other molecular function","FUCA1","ENSG00000179163","Other glycan degradation; Lysosome","Neutrophil degranulation; Reactions specific to the complex N-glycan synthesis pathway","p53 transcriptional gene network",3383.7,3322.8,3349.3,2821,2693.4,2298.4,1.2870929756297358,0.3641162731662758,0.009148896438972348,2.0386312883782454,0.11411140626697763,0.9426709425123629,586]
["P04075","fructose-bisphosphate aldolase A [OS=Homo sapiens]",77,29,534,21,364,39.4,8.09,1806.83,"cell organization and biogenesis;other metabolic processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ALDOA","ENSG00000149925","Glycolysis / Gluconeogenesis; Pentose phosphate pathway; Fructose and mannose metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; HIF-1 signaling pathway","Neutrophil degranulation; Glycolysis; Platelet degranulation ; Gluconeogenesis","VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; 16p11.2 proximal deletion syndrome; Glycolysis and gluconeogenesis; Sudden infant death syndrome (SIDS) susceptibility pathways",64202.7,62884.4,59554.2,59033.5,57098.5,60892.3,{"$f":"AVERAGE(S962:U962)/AVERAGE(V962:X962)","v":1.0543258750352353},{"$f":"LOG(Y962,2)","v":0.07632084954982765},{"$f":"TTEST(V962:X962,S962:U962,2,2)","v":0.14338062412505145},0.8435095334947176,{"$f":"AA962*7309/AE962","v":0.39710836746115996},0.40109096183079423,2639]
["P04080","Cystatin-B [OS=Homo sapiens]",52,4,24,4,98,11.1,7.56,83.31,"other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","CSTB","ENSG00000160213","","Neutrophil degranulation","",3227.7,3456.3,4517.8,3610.7,3643.5,3212.9,1.0701913615041414,0.09786878878426701,0.5918461310424112,{"$f":"-LOG10(AA963)","v":0.22779118706934098},0.7329385584190078,{"$f":"-LOG10(AC963)","v":0.13493243034930866},5902]
["P04114","apolipoprotein B-100 [OS=Homo sapiens]",1,2,2,2,4563,515.3,7.05,5.51,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;transporter activity;other molecular function","APOB","ENSG00000084674","Fat digestion and absorption; Vitamin digestion and absorption; Cholesterol metabolism; Lipid and atherosclerosis","Heme signaling; Cell surface interactions at the vascular wall; Scavenging by Class B Receptors; Regulation of TLR by endogenous ligand; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Retinoid metabolism and transport; Cargo recognition for clathrin-mediated endocytosis; LDL clearance; Chylomicron clearance; Scavenging by Class A Receptors; Chylomicron assembly; Chylomicron remodeling; VLDL assembly; VLDL clearance; Scavenging by Class F Receptors; Scavenging by Class H Receptors; Platelet sensitization by LDL; LDL remodeling","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Statin inhibition of cholesterol production; Male infertility; Familial hyperlipidemia type 2",273.1,282.8,235.8,201.1,184.1,460.9,0.9357049994090535,-0.09587433321070792,0.8513010783422783,0.06991681648686704,0.9059638295870286,0.042889141091772956,6868]
["P04150","Glucocorticoid receptor [OS=Homo sapiens]",27,15,26,15,777,85.6,6.38,70.1,"cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","NR3C1","ENSG00000113580","Neuroactive ligand-receptor interaction","Potential therapeutics for SARS; Regulation of RUNX2 expression and activity; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Circadian Clock; SUMOylation of intracellular receptors; PTK6 Expression","Nuclear receptors; Adipogenesis; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Endoderm differentiation; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Transcription factor regulation in adipogenesis; White fat cell differentiation; Vitamin D in inflammatory diseases; 16p11.2 proximal deletion syndrome; Sudden infant death syndrome (SIDS) susceptibility pathways; Serotonin receptor 4/6/7 and NR3C signaling",1861.1,1766.1,1871.9,1932.4,1955.2,1829.2,0.9619192555275679,-0.05601229708637942,0.23015119282484264,0.6379867699079405,0.4902871082357257,0.3095495260801409,3431]
["P04156-1","Major prion protein [OS=Homo sapiens]",20,5,16,5,253,27.6,9,32.24,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function","PRNP","ENSG00000171867","Ferroptosis; Prion disease; Pathways of neurodegeneration","NCAM1 interactions; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","Complement system; Copper homeostasis; Prion disease pathway; Ferroptosis",1500.4,1524.2,1491.6,1452.4,1590.8,1661.7,0.9598928776382072,-0.059054682306980966,0.36926710464387197,0.43265937880436506,0.5922697537507263,0.2274804455028409,4557]
["P04179","Superoxide dismutase [Mn], mitochondrial [OS=Homo sapiens]",39,7,31,7,222,24.7,8.25,102.06,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","mitochondrion","other molecular function","SOD2","ENSPPAG00000038347","FoxO signaling pathway; Peroxisome; Longevity regulating pathway; Longevity regulating pathway; Huntington disease; Chemical carcinogenesis; Lipid and atherosclerosis","","",4119.5,3806.5,4532.2,3830.3,3969.7,4373,1.0234289000246448,0.03341087847773655,0.7386547760131863,0.1315584897554506,0.8317405265568293,0.0800121370026014,6491]
["P04181-1","Ornithine aminotransferase, mitochondrial [OS=Homo sapiens]",51,15,92,15,439,48.5,7.03,291.77,"other metabolic processes;other biological processes","mitochondrion;nucleus;other cell component","other molecular function","OAT","ENSG00000065154; ENSPPAG00000034558; ENSPTRG00000003028","Arginine and proline metabolism; Metabolic pathways","Glutamate and glutamine metabolism","Amino acid metabolism; 22q11.2 copy number variation syndrome",9485.7,9626.5,10128.6,8646.5,7964.1,6560.2,1.261967648937456,0.33567492671053195,0.03485188527204566,1.4577737242775672,0.20592759050394643,0.686285462022715,1237]
["P04183","Thymidine kinase, cytosolic [OS=Homo sapiens]",43,9,38,9,234,25.5,8.51,104.68,"cell organization and biogenesis;DNA metabolism;other metabolic processes","cytosol","kinase activity;other molecular function","TK1","ENSG00000167900","Pyrimidine metabolism; Drug metabolism; Metabolic pathways","Pyrimidine salvage; G1/S-Specific Transcription","Fluoropyrimidine activity; Pyrimidine metabolism",2740.3,3180.7,3200,2661.7,2327.1,1782.2,1.3470683798552654,0.42982308671274666,0.05774605130117219,1.2384777076564761,0.2615030290955809,0.5825232761585547,1614]
["P04233-2","Isoform 2 of HLA class II histocompatibility antigen gamma chain [OS=Homo sapiens]",48,10,116,10,232,26.4,9.14,330.43,"","","","CD74","","","","",15153.5,13909.9,14547.6,12989.7,15204.5,13950.3,1.0347969485935296,0.049347704926291494,0.5423333007836302,0.2657337278482435,0.6967681658336357,0.15691169973204205,5689]
["P04259","keratin, type II cytoskeletal 6B [OS=Homo sapiens]",31,21,79,2,564,60,8,188.7,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","cytoskeletal activity","KRT6B","ENSG00000185479","","Formation of the cornified envelope","",287.3,212.1,261.3,194.8,259.3,578.2,0.7368981885110917,-0.44046278774683023,0.49443662637169605,0.305889365504298,0.6649194668170609,0.17723095204263845,5435]
["P04264","Keratin, type II cytoskeletal 1 [OS=Homo sapiens]",52,37,272,31,644,66,8.12,762.82,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","bone, tooth or skin structural activity;other molecular function","KRT1","ENSG00000167768","","Neutrophil degranulation; Formation of the cornified envelope","Corticotropin-releasing hormone signaling pathway",34551.9,36804.2,30265.8,27217.1,41089.7,33969.5,0.9936016457380645,-0.009260531739416865,0.963176364048583,0.016294183363267798,0.9777577840043185,9.768717910563305E-3,7200]
["P04406-1","glyceraldehyde-3-phosphate dehydrogenase [OS=Homo sapiens]",79,22,1504,22,335,36,8.46,5838.71,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","GAPDH; HEL-S-162eP; LOC117800120","ENSAMEG00000025937; ENSG00000111640; ENSGGOG00000009553; ENSPPAG00000039909; ENSPTRG00000004577","Glycolysis / Gluconeogenesis; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; HIF-1 signaling pathway; Alzheimer disease; Pathogenic Escherichia coli infection; Salmonella infection; Diabetic cardiomyopathy","Glycolysis; Gluconeogenesis","Cori cycle; Alzheimer's disease and miRNA effects; HIF1A and PPARG regulation of glycolysis; VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; 7q11.23 copy number variation syndrome; Glycolysis in senescence; Alzheimer's disease; Glycolysis and gluconeogenesis; Sudden infant death syndrome (SIDS) susceptibility pathways",139648.6,139466.6,133391.5,125776.7,120659.5,111905.4,1.1511549314955338,0.2030820157969396,0.01646711833620723,1.78338239355519,0.14932775176096608,0.8258594734763077,806]
["P04424","argininosuccinate lyase [OS=Homo sapiens]",19,8,21,8,464,51.6,6.48,62.06,"other metabolic processes","cytosol;other cell component","other molecular function","ASL","ENSG00000126522","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; Metabolic pathways; Biosynthesis of amino acids","Urea cycle","Alanine and aspartate metabolism",2033.8,1858.4,2003.1,1753.1,1764.7,2077.2,1.0536729222520105,0.07542709973020482,0.44807285239352684,0.3486513680995563,0.6335779605618664,0.1981999383832743,5169]
["P04632","Calpain small subunit 1 [OS=Homo sapiens]",77,12,90,12,268,28.3,5.2,324.41,"protein metabolism;other biological processes","plasma membrane;other membranes;cytosol","other molecular function","CAPNS1","ENSG00000126247","Shigellosis","Formation of the cornified envelope; Degradation of the extracellular matrix; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models","Integrin-mediated cell adhesion",8511.6,8526.5,8178.3,8200,8346.5,5359.8,1.1511026508356044,0.20301649311224398,0.3226272873239889,0.49129890342857735,0.5664383480785574,0.24684735243138178,4163]
["P04637","Cellular tumor antigen p53 [OS=Homo sapiens]",6,3,3,3,393,43.6,6.79,7.18,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function","TP53","ENSG00000141510","Endocrine resistance; Platinum drug resistance; MAPK signaling pathway; Sphingolipid signaling pathway; Cell cycle; p53 signaling pathway; Mitophagy; PI3K-Akt signaling pathway; Apoptosis; Longevity regulating pathway; Ferroptosis; Cellular senescence; Wnt signaling pathway; Neurotrophin signaling pathway; Thyroid hormone signaling pathway; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Shigellosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Pathways in cancer; Transcriptional misregulation in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Colorectal cancer; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Thyroid cancer; Basal cell carcinoma; Melanoma; Bladder cancer; Chronic myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","TP53 Regulates Transcription of DNA Repair Genes; Autodegradation of the E3 ubiquitin ligase COP1; Ub-specific processing proteases; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of PTEN gene transcription; Factors involved in megakaryocyte development and platelet production; Interleukin-4 and Interleukin-13 signaling; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; TP53 Regulates Transcription of Death Receptors and Ligands; Oxidative Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Association of TriC/CCT with target proteins during biosynthesis; Pre-NOTCH Transcription and Translation; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; TP53 Regulates Transcription of Caspase Activators and Caspases; Regulation of TP53 Activity through Methylation; G2/M DNA damage checkpoint; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Activation of PUMA and translocation to mitochondria; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; Regulation of TP53 Activity through Association with Co-factors; Ovarian tumor domain proteases; Pyroptosis; SUMOylation of transcription factors; Regulation of TP53 Expression; RUNX3 regulates CDKN1A transcription; Activation of NOXA and translocation to mitochondria; Formation of Senescence-Associated Heterochromatin Foci (SAHF); PI5P Regulates TP53 Acetylation; Transcriptional  activation of  cell cycle inhibitor p21 ; Loss of function of TP53 in cancer due to loss of tetramerization ability","AMP-activated protein kinase (AMPK) signaling; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Fluoropyrimidine activity; TP53 network; Folate metabolism; Apoptosis modulation and signaling; Cell cycle; Metastatic brain tumor; Glioblastoma signaling pathways; Gastric cancer network 2; Oncostatin M signaling pathway; Spinal cord injury; Retinoblastoma gene in cancer; Amyotrophic lateral sclerosis (ALS); ATM signaling pathway; Apoptosis; Mammary gland development pathway - Involution (Stage 4 of 4); Bladder cancer; Copper homeostasis; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced HIF-1 survival signaling; Hepatitis C and hepatocellular carcinoma; Pathways affected in adenoid cystic carcinoma; TGF-beta signaling pathway; lncRNA-mediated mechanisms of therapeutic resistance; MAPK signaling pathway; miRNA regulation of p53 pathway in prostate cancer; Wnt signaling pathway and pluripotency; Endometrial cancer; PI3K-Akt signaling pathway; Caloric restriction and aging; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer; Ferroptosis; Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome; MicroRNA network associated with chronic lymphocytic leukemia; G1 to S cell cycle control; 22q11.2 copy number variation syndrome; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Unfolded protein response; 16p11.2 proximal deletion syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis in senescence; TCA cycle in senescence; Malignant pleural mesothelioma; Senescence and autophagy in cancer; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)",344,287.8,332.9,230.8,246.5,335.4,1.187030884705303,0.2473574721588594,0.24084858319221714,0.6182559041081597,0.49981893655647786,0.3011872938554448,3522]
["P04792","Heat shock protein beta-1 [OS=Homo sapiens]",29,5,7,5,205,22.8,6.4,25.69,"stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","HSPB1","ENSG00000106211","MAPK signaling pathway; VEGF signaling pathway; Amoebiasis","AUF1 (hnRNP D0) binds and destabilizes mRNA; MAPK6/MAPK4 signaling; Extra-nuclear estrogen signaling; VEGFA-VEGFR2 Pathway","Apoptosis-related network due to altered Notch3 in ovarian cancer; Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; ATM signaling in development and disease ; VEGFA-VEGFR2 signaling pathway; p38 MAPK signaling pathway; Extracellular vesicles in the crosstalk of cardiac cells; Ferroptosis; IL-18 signaling pathway; Intracellular trafficking proteins involved in CMT neuropathy",871.1,914.5,906.9,783.3,757.3,814.9,1.1430694120144345,0.1929130127636489,0.006262331069433446,2.203263976350632,0.09656408815714992,1.015184356140744,474]
["P04818","thymidylate synthase [OS=Homo sapiens]",15,5,6,5,313,35.7,7.01,3.92,"DNA metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","TYMS","ENSG00000176890","Pyrimidine metabolism; One carbon pool by folate; Metabolic pathways; Antifolate resistance","Interconversion of nucleotide di- and triphosphates; G1/S-Specific Transcription","Fluoropyrimidine activity; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration and one-carbon metabolism; One-carbon metabolism and related pathways; Ethanol effects on histone modifications; Pyrimidine metabolism",335.3,307.6,320.3,583.7,632.5,590.8,0.5330381848367459,-0.90768920899226,8.1830046511368359E-5,4.087087201975255,0.020623993446606596,1.685627237990238,29]
["P04839","Cytochrome b-245 heavy chain [OS=Homo sapiens]",4,2,4,2,570,65.3,8.63,5.85,"other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","CYBB","ENSG00000165168","HIF-1 signaling pathway; Phagosome; Ferroptosis; Necroptosis; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Leukocyte transendothelial migration; AGE-RAGE signaling pathway in diabetic complications; Alzheimer disease; Prion disease; Pathways of neurodegeneration; Leishmaniasis; Coronavirus disease; Diabetic cardiomyopathy; Lipid and atherosclerosis","Neutrophil degranulation; RAC2 GTPase cycle; RAC3 GTPase cycle; RAC1 GTPase cycle; Detoxification of Reactive Oxygen Species; VEGFA-VEGFR2 Pathway; ROS and RNS production in phagocytes; Cross-presentation of particulate exogenous antigens (phagosomes); RHO GTPases Activate NADPH Oxidases","Alzheimer's disease and miRNA effects; VEGFA-VEGFR2 signaling pathway; Microglia pathogen phagocytosis pathway; Oxidative stress response; Ferroptosis; Alzheimer's disease; Type II interferon signaling (IFNG)",596.7,504,492.6,525.6,510.7,422.4,1.0922739425515873,0.12733472988088237,0.38540316568174543,0.41408472239341726,0.599087991911501,0.22250938529836484,4702]
["P04843","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [OS=Homo sapiens]",63,36,375,36,607,68.5,6.38,1108.82,"protein metabolism;other metabolic processes","other membranes;cytosol;ER/Golgi;other cell component","","RPN1","ENSG00000163902","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum","SRP-dependent cotranslational protein targeting to membrane; Asparagine N-linked glycosylation; Maturation of spike protein","Proteasome degradation",45793.3,45483.6,45953.2,41985.2,41427.5,36981.5,1.1398397929468362,0.1888310645976752,0.024199278856098808,1.61619757589905,0.17651949017886845,0.753207335546304,1002]
["P04844-1","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [OS=Homo sapiens]",52,22,187,1,631,69.2,5.69,634.88,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus;other cytoplasmic organelle","translation activity","RPN2","ENSG00000118705","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum","SRP-dependent cotranslational protein targeting to membrane; Asparagine N-linked glycosylation; Maturation of spike protein","Proteasome degradation",488.9,570.2,557.6,395.3,382.7,127.3,1.7858168562907324,0.83658413305198,0.059482757344012906,1.2256089078109134,0.2633309954133194,0.579498019189734,1651]
["P04844-2","Isoform 2 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [OS=Homo sapiens]",49,22,161,1,615,67.7,6.06,563.89,"","","","RPN2","","","","",13392.2,14031.2,14695,11247,10539,9175.7,1.360338741089798,0.44396594503383313,0.006503357908714405,2.186862344177186,0.09780461513332013,1.0096406515555063,486]
["P04899-1","guanine nucleotide-binding protein G(i) subunit alpha-2 [OS=Homo sapiens]",60,16,67,9,355,40.4,5.54,231.53,"cell-cell signaling;cell cycle OR cell proliferation;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","GNAI2","ENSCANG00000029469; ENSCATG00000043630; ENSCSAG00000014329; ENSG00000114353; ENSMFAG00000032665; ENSMMUG00000056280; ENSMNEG00000033996; ENSNLEG00000006962; ENSPANG00000023235; ENSPTRG00000014951; ENSRBIG00000038900; ENSRROG00000029350; ENSTSYG00000005938","Rap1 signaling pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Adrenergic signaling in cardiomyocytes; Axon guidance; Apelin signaling pathway; Gap junction; Platelet activation; Leukocyte transendothelial migration; Circadian entrainment; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; GABAergic synapse; Dopaminergic synapse; Long-term depression; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Melanogenesis; Oxytocin signaling pathway; Regulation of lipolysis in adipocytes; Renin secretion; Relaxin signaling pathway; Parathyroid hormone synthesis, secretion and action; Cushing syndrome; Growth hormone synthesis, secretion and action; Gastric acid secretion; Parkinson disease; Cocaine addiction; Morphine addiction; Alcoholism; Pertussis; Chagas disease; Toxoplasmosis; Human cytomegalovirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Chemical carcinogenesis","G alpha (i) signalling events; G alpha (z) signalling events; Adenylate cyclase inhibitory pathway; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; ADORA2B mediated anti-inflammatory cytokines production; Adrenaline,noradrenaline inhibits insulin secretion","Thyroid stimulating hormone (TSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; S1P receptor signal transduction; Complement system; G protein signaling pathways; Chemokine signaling pathway; Hippo signaling regulation pathways; Purinergic signaling; Calcium regulation in cardiac cells; Calcium regulation in cardiac cells",8456.9,9762.5,9328.7,7375.3,6896.3,7728.2,1.2521977472522479,0.3244624108747986,0.015100563253458581,1.8210068531500905,0.1433376841812062,0.8436396164385994,770]
["P04920-1","Anion exchange protein 2 [OS=Homo sapiens]",26,23,59,23,1241,136.9,6.29,248.64,"transport;developmental processes;other biological processes","plasma membrane;other membranes","transporter activity;other molecular function","SLC4A2","ENSG00000164889","Salivary secretion; Gastric acid secretion; Pancreatic secretion; Bile secretion","Bicarbonate transporters","Proximal tubule transport",4283.3,4154,4134.1,3627.6,3698.9,4072.9,1.1028124287243188,0.14118743176242643,0.05525690573198138,1.2576134382966506,0.2559396223035817,0.5918624752860792,1578]
["P04921-1","Glycophorin-C [OS=Homo sapiens]",27,2,4,2,128,13.8,4.84,19.82,"","plasma membrane;other membranes;cytoskeleton","","GYPC","ENSG00000136732","Malaria","Cell surface interactions at the vascular wall","",380.6,372.9,390.5,441.9,473,758.7,0.6835564053537284,-0.5488677045811897,0.15523488138627442,0.8090106858389104,0.41198683662029045,0.38511665987584226,2754]
["P05023","Sodium/potassium-transporting ATPase subunit alpha-1 [OS=Homo sapiens]",46,42,245,42,1023,112.8,5.49,823.18,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;cytoskeletal activity;other molecular function","ATP1A1","ENSG00000163399","cGMP-PKG signaling pathway; cAMP signaling pathway; Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Insulin secretion; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Aldosterone synthesis and secretion; Aldosterone-regulated sodium reabsorption; Endocrine and other factor-regulated calcium reabsorption; Proximal tubule bicarbonate reclamation; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Carbohydrate digestion and absorption; Protein digestion and absorption; Bile secretion; Mineral absorption","Ion homeostasis; Ion transport by P-type ATPases; Potential therapeutics for SARS","Pre-implantation embryo; Proximal tubule transport",26922.9,26077.4,25264.8,20977.8,21878.1,23742.2,1.1751851779555273,0.23288810510408453,0.01463334905386189,1.8346562679170533,0.14073045820352176,0.8516118983138717,760]
["P05026","Sodium/potassium-transporting ATPase subunit beta-1 [OS=Homo sapiens]",8,3,5,3,303,35,8.53,5.59,"cell adhesion;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","transporter activity;other molecular function","ATP1B1","ENSG00000143153","cGMP-PKG signaling pathway; cAMP signaling pathway; Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Insulin secretion; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Aldosterone synthesis and secretion; Aldosterone-regulated sodium reabsorption; Endocrine and other factor-regulated calcium reabsorption; Proximal tubule bicarbonate reclamation; Salivary secretion; Gastric acid secretion; Pancreatic secretion; Carbohydrate digestion and absorption; Protein digestion and absorption; Bile secretion; Mineral absorption","Ion homeostasis; Ion transport by P-type ATPases; Potential therapeutics for SARS; Basigin interactions","Proximal tubule transport; Calcium regulation in cardiac cells",606,590.1,602.7,505,511.5,626.3,1.0949598246895544,0.13087793668996006,0.26032941876038246,0.5844767512785217,0.5177544821005811,0.28587613281476243,3675]
["P05062","fructose-bisphosphate aldolase B [OS=Homo sapiens]",6,3,32,1,364,39.4,7.87,72.4,"cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;cytoskeleton","cytoskeletal activity;other molecular function","ALDOB","ENSG00000136872","Glycolysis / Gluconeogenesis; Pentose phosphate pathway; Fructose and mannose metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; HIF-1 signaling pathway","Glycolysis; Gluconeogenesis; Fructose catabolism; Hereditary fructose intolerance","Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Glycolysis and gluconeogenesis; Polyol pathway",44.4,47.6,50,37,39.8,83.7,0.8847352024922119,-0.1766823676176209,0.7058770429688801,0.15127094230613242,0.8103118120087239,0.09134783028600117,6367]
["P05067-1","Amyloid-beta A4 protein [OS=Homo sapiens]",13,8,19,8,770,86.9,4.82,63.9,"cell adhesion;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function","APP","ENSG00000142192","Serotonergic synapse; Alzheimer disease; Pathways of neurodegeneration","Amyloid fiber formation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Platelet degranulation ; G alpha (q) signalling events; G alpha (i) signalling events; ECM proteoglycans; Lysosome Vesicle Biogenesis; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; TRAF6 mediated NF-kB activation; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Formyl peptide receptors bind formyl peptides and many other ligands; Advanced glycosylation endproduct receptor signaling","Alzheimer's disease and miRNA effects; Endoderm differentiation; Apoptosis-related network due to altered Notch3 in ovarian cancer; Copper homeostasis; TGF-beta signaling pathway; Fragile X syndrome; Inclusion body myositis; Alzheimer's disease",2111.5,2058.9,1985.6,2191.8,2379.7,2105.2,0.9220123713810715,-0.11714198630392161,0.12251436331696224,0.911812992575981,0.37078984740524923,0.4308721657795391,2415]
["P05089","Arginase-1 [OS=Homo sapiens]",7,2,2,2,322,34.7,7.21,2.25,"other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","ARG1","ENSG00000118520","Arginine biosynthesis; Arginine and proline metabolism; Metabolic pathways; Biosynthesis of amino acids; Amoebiasis","Neutrophil degranulation; Urea cycle","Spinal cord injury; Amino acid metabolism; IL-18 signaling pathway",180.3,194.4,173.2,165.7,189,171.5,1.0412390725959713,0.05830135514009053,0.48335125120707995,0.3157371528513202,0.6561690741219441,0.18298424218326767,5384]
["P05091","Aldehyde dehydrogenase, mitochondrial [OS=Homo sapiens]",4,2,2,1,517,56.3,7.05,6.5,"other metabolic processes","mitochondrion","other molecular function","ALDH2","ENSG00000111275","Glycolysis / Gluconeogenesis; Ascorbate and aldarate metabolism; Fatty acid degradation; Valine, leucine and isoleucine degradation; Lysine degradation; Arginine and proline metabolism; Histidine metabolism; Tryptophan metabolism; beta-Alanine metabolism; Glycerolipid metabolism; Pyruvate metabolism; Pantothenate and CoA biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Alcoholic liver disease","Ethanol oxidation; Metabolism of serotonin","Fatty acid omega-oxidation; Ethanol effects on histone modifications; Tryptophan metabolism; Fluoroacetic acid toxicity",79.2,57.7,73.9,84,84.5,61.8,0.915327833260964,-0.12763954415563092,0.5469865458624127,0.26202335580472774,0.7001619376021672,0.15480150216660282,5710]
["P05114","Non-histone chromosomal protein HMG-14 [OS=Homo sapiens]",51,6,23,6,100,10.7,9.6,67.88,"cell organization and biogenesis;DNA metabolism;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HMGN1","ENSG00000205581","","Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER","ATM signaling in development and disease ; p38 MAPK signaling pathway; Malignant pleural mesothelioma; Nucleotide excision repair in xeroderma pigmentosum",3512.4,2777.1,2462.9,2531,2860.3,1567.3,1.2577817377058604,0.3308815937205454,0.29545300237928157,0.5295115923821337,0.5447694234082161,0.2637872763113986,3964]
["P05141","ADP/ATP translocase 2 [OS=Homo sapiens]",52,18,249,5,298,32.8,9.69,692.48,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion","transporter activity;other molecular function","SLC25A5","ENSG00000005022","Calcium signaling pathway; cGMP-PKG signaling pathway; Necroptosis; Cellular senescence; Neutrophil extracellular trap formation; Alzheimer disease; Parkinson disease; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Influenza A; Human T-cell leukemia virus 1 infection; Chemical carcinogenesis; Diabetic cardiomyopathy","Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization","Electron transport chain: OXPHOS system in mitochondria; Alzheimer's disease and miRNA effects; Alzheimer's disease",37950.6,39985.6,38934,35261.3,33767.1,49370.8,0.9870860613923066,-0.018752220001908897,0.9237993144883261,0.034422364360578085,0.9509928436049543,0.021822751195680404,7100]
["P05161","Ubiquitin-like protein ISG15 [OS=Homo sapiens]",10,2,3,2,165,17.9,7.44,6.18,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;cytosol;translational apparatus;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ISG15","ENSG00000187608","RIG-I-like receptor signaling pathway; Human papillomavirus infection; Epstein-Barr virus infection; Coronavirus disease","Interferon alpha/beta signaling; ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling","Novel intracellular components of RIG-I-like receptor (RLR) pathway; Non-genomic actions of 1,25 dihydroxyvitamin D3; Cytosolic DNA-sensing pathway; p53 transcriptional gene network; Type II interferon signaling (IFNG)",333.1,337.9,349.5,298.1,264.3,156.3,1.4199248643383886,0.5058145911987609,0.0795965993153456,1.0991054866609384,0.3066797809150559,0.513314855665628,1897]
["P05165-1","Propionyl-CoA carboxylase alpha chain, mitochondrial [OS=Homo sapiens]",28,16,30,16,728,80,7.52,89.32,"other metabolic processes","cytosol;mitochondrion","other molecular function","PCCA","ENSG00000175198","Valine, leucine and isoleucine degradation; Glyoxylate and dicarboxylate metabolism; Propanoate metabolism; Metabolic pathways; Carbon metabolism","Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency; Propionyl-CoA catabolism","",2527.7,2591.6,2538.8,2367.7,2313.9,2650.3,1.0444905140550198,0.06279939007096166,0.3636804835928538,0.43928000412909046,0.5887354716678115,0.23007979689464206,4515]
["P05166-1","propionyl-CoA carboxylase beta chain, mitochondrial [OS=Homo sapiens]",21,9,15,9,539,58.2,7.64,54.36,"other metabolic processes","cytosol;mitochondrion","other molecular function","PCCB","ENSG00000114054","Valine, leucine and isoleucine degradation; Glyoxylate and dicarboxylate metabolism; Propanoate metabolism; Metabolic pathways; Carbon metabolism","Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency; Propionyl-CoA catabolism","",1635.1,1585.6,1604.6,1562.6,1517.8,1395.8,1.0779902595951922,0.10834414237873098,0.08834419578093242,1.053821978393973,0.32060959630726665,0.49402348272759933,2014]
["P05198","Eukaryotic translation initiation factor 2 subunit 1 [OS=Homo sapiens]",66,20,221,20,315,36.1,5.08,697.51,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;translational apparatus;nucleus;other cell component","translation activity;nucleic acid binding activity","EIF2S1","ENSG00000134001","Autophagy; Protein processing in endoplasmic reticulum; Apoptosis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Prion disease; Pathways of neurodegeneration; Hepatitis C; Measles; Influenza A; Herpes simplex virus 1 infection; Lipid and atherosclerosis","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency","Translation factors; Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; Ebola virus pathway in host; Nonalcoholic fatty liver disease; Unfolded protein response; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; Alzheimer's disease",19573.7,19790,19474.4,17837,17392,15061,1.1699761383972958,0.22647910641813718,0.030190127333721287,1.5201350552373893,0.1942426414455712,0.7116554247284165,1136]
["P05204","Non-histone chromosomal protein HMG-17 [OS=Homo sapiens]",16,2,9,2,90,9.4,9.99,21.42,"cell organization and biogenesis;other biological processes","non-structural extracellular;nucleus;other cell component","nucleic acid binding activity;other molecular function","HMGN2","ENSG00000198830","","","",2004.3,1863.2,1617.4,1221.9,1158.2,975.8,1.634405077624482,0.708765591227513,6.2634206371177175E-3,2.2031884210873285,0.09637756091935452,1.016024068828222,475]
["P05362","Intercellular adhesion molecule 1 [OS=Homo sapiens]",24,9,19,9,532,57.8,7.99,72.98,"cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","ICAM1","ENSG00000090339","NF-kappa B signaling pathway; Cell adhesion molecules; Natural killer cell mediated cytotoxicity; TNF signaling pathway; Leukocyte transendothelial migration; AGE-RAGE signaling pathway in diabetic complications; African trypanosomiasis; Malaria; Staphylococcus aureus infection; Influenza A; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Epstein-Barr virus infection; Rheumatoid arthritis; Viral myocarditis; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","Interleukin-4 and Interleukin-13 signaling; Interferon gamma signaling; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Integrin cell surface interactions; Interleukin-10 signaling","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; RANKL/RANK signaling pathway; Interleukin-11 signaling pathway; Spinal cord injury; Complement system; IL1 and megakaryocytes in obesity; Photodynamic therapy-induced NF-kB survival signaling; VEGFA-VEGFR2 signaling pathway; miRNAs involvement in the immune response in sepsis; Cells and molecules involved in local acute inflammatory response ; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; CAMKK2 pathway; p53 transcriptional gene network; Orexin receptor pathway; Type II interferon signaling (IFNG)",2333.8,2258.7,2308.1,2336.2,2363.9,1999.8,1.0299556709801638,0.042582245531473294,0.6042352830748309,0.21879391859052674,0.7411236254394931,0.1301093421313405,5959]
["P05386","60S acidic ribosomal protein P1 [OS=Homo sapiens]",57,3,24,3,114,11.5,4.32,86.06,"protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus","enzyme regulator activity;other molecular function","RPLP1","ENSG00000137818","Ribosome; Coronavirus disease","L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",2438.1,2131,3390.8,3507.1,3955.9,3739.2,0.7105657817214476,-0.4929598795216515,0.05428331517780884,1.2653336370722938,0.25335680117152287,0.5962674329102454,1566]
["P05455","Lupus La protein [OS=Homo sapiens]",70,34,273,34,408,46.8,7.12,717.54,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","nucleus;other cell component","nucleic acid binding activity","SSB","ENSG00000138385","Systemic lupus erythematosus","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination","",38009.1,38430.9,37449.7,38798.5,38169.2,27350.4,1.0917539717460343,0.1266477795797064,0.4401542998639547,0.35639505116754144,0.6290746534426368,0.20129781297388516,5114]
["P06213-1","insulin receptor [OS=Homo sapiens]",10,12,19,11,1382,156.2,6.2,54.6,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","INSR","ENSG00000171105","MAPK signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cGMP-PKG signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Phospholipase D signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Adherens junction; Insulin signaling pathway; Ovarian steroidogenesis; Regulation of lipolysis in adipocytes; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; Aldosterone-regulated sodium reabsorption; Alzheimer disease; Diabetic cardiomyopathy","PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Insulin receptor recycling; IRS activation; Signal attenuation","AMP-activated protein kinase (AMPK) signaling; Selenium micronutrient network; Vitamin B12 metabolism; Type II diabetes mellitus; Folate metabolism; Alzheimer's disease and miRNA effects; AGE/RAGE pathway; Nanoparticle triggered autophagic cell death; Transcription factor regulation in adipogenesis; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; PI3K-Akt signaling pathway; Ras signaling; NRF2-ARE regulation; Nonalcoholic fatty liver disease; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Male infertility; Insulin signaling; 16p11.2 distal deletion syndrome; Neuroinflammation and glutamatergic signaling; Malignant pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)",1646.5,1691.3,1685.4,1830.5,1811.1,1720.2,0.9368495654444405,-0.09411068906398398,0.03736442762865234,1.4275416661475904,0.21236127646797817,0.6729246728518208,1286]
["P06396","Gelsolin [OS=Homo sapiens]",10,8,12,8,782,85.6,6.28,27.52,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","GSN","ENSG00000148180","Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Viral carcinogenesis","Neutrophil degranulation; Amyloid fiber formation; Sensory processing of sound by outer hair cells of the cochlea; Caspase-mediated cleavage of cytoskeletal proteins","Ebola virus pathway in host; Regulation of actin cytoskeleton; Senescence and autophagy in cancer",1655.7,1617.8,1587.5,1461.6,1570.1,1354.6,1.1082233317374555,0.14824864593828768,0.07240681362045316,1.140220563933642,0.29368557200437967,0.5321173886927132,1802]
["P06737-1","Glycogen phosphorylase, liver form [OS=Homo sapiens]",8,7,11,4,847,97.1,7.17,27.47,"other metabolic processes;other biological processes","non-structural extracellular;cytosol;other cell component","other molecular function","PYGL","ENSG00000100504; ENSPPAG00000035478; ENSPTRG00000006337","Starch and sucrose metabolism; Metabolic pathways; Necroptosis; Insulin signaling pathway; Glucagon signaling pathway; Insulin resistance","Neutrophil degranulation; Glycogen breakdown (glycogenolysis)","TNF-alpha signaling pathway; Glycogen synthesis and degradation; Glycogen metabolism",164.5,148.1,167.7,136.8,136.6,233.9,0.9467770549970431,-0.07890335189372638,0.7983493836341902,0.09780700567009262,0.8724784158167309,0.0592453082170796,6688]
["P06858","lipoprotein lipase [OS=Homo sapiens]",1,1,1,1,475,53.1,8.15,1.76,"cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes","signal transduction activity or receptor binding;other molecular function","LPL","ENSG00000175445","Glycerolipid metabolism; PPAR signaling pathway; Cholesterol metabolism; Alzheimer disease","Transcriptional regulation of white adipocyte differentiation; Retinoid metabolism and transport; Assembly of active LPL and LIPC lipase complexes; Chylomicron remodeling","Fatty acid beta-oxidation; Sterol regulatory element-binding proteins (SREBP) signaling; Alzheimer's disease and miRNA effects; Adipogenesis; Aryl hydrocarbon receptor Netpath; Triacylglyceride synthesis; Lipid particles composition; Angiopoietin-like protein 8 regulatory pathway; PPAR signaling pathway; Statin inhibition of cholesterol production; Metabolic pathway of LDL, HDL and TG, including diseases; Overview of leukocyte-intrinsic Hippo pathway functions; Orexin receptor pathway; Familial partial lipodystrophy (FPLD); Familial  hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5; Alzheimer's disease; Vitamin A and carotenoid metabolism",75.7,64.4,68.8,78.7,91.2,91,0.8006899195093907,-0.32068445175034355,0.03045985790040252,1.5162721270411783,0.19477786648647596,0.7104603955524871,1143]
["P07099","epoxide hydrolase 1 [OS=Homo sapiens]",39,15,66,15,455,52.9,7.25,209.82,"other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","EPHX1","ENSG00000143819","Metabolism of xenobiotics by cytochrome P450; Bile secretion; Chemical carcinogenesis; Chemical carcinogenesis; Chemical carcinogenesis","Phase I - Functionalization of compounds","Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Benzene metabolism; Benzo(a)pyrene metabolism; Aflatoxin B1 metabolism; Metapathway biotransformation Phase I and II",7741.9,7790.3,7692.8,6094.4,6182.6,6299.1,1.2502624339877586,0.32223095286654385,1.90663470122877E-5,4.7197325069736635,0.01393559303128108,1.8558745450896905,10]
["P07311","Acylphosphatase-1 [OS=Homo sapiens]",26,3,5,3,99,11.3,9.31,14.66,"other metabolic processes","","other molecular function","ACYP1","ENSG00000119640","Pyruvate metabolism; Metabolic pathways","","",796.9,786,810.8,783.2,854.7,1004.2,0.9059838764619051,-0.14244271962185373,0.27484793664185486,0.5609075190526995,0.5282312829122581,0.27717588258030895,3803]
["P07384","Calpain-1 catalytic subunit [OS=Homo sapiens]",57,35,159,34,714,81.8,5.67,466.75,"protein metabolism;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","CAPN1","ENSG00000014216","Protein processing in endoplasmic reticulum; Apoptosis; Necroptosis; Cellular senescence; Alzheimer disease; Pathways of neurodegeneration; Shigellosis","Degradation of the extracellular matrix; Neutrophil degranulation; Formation of the cornified envelope; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models","Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Alzheimer's disease",17227.2,17624.6,17618.9,15734.6,15584.8,15426,1.1224783615072285,0.1666876337885953,2.7526038054806451E-4,3.5602562940465425,0.02579330924904876,1.5884929348530499,78]
["P07741-1","Adenine phosphoribosyltransferase [OS=Homo sapiens]",74,12,84,12,180,19.6,6.02,249.53,"other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","APRT","ENSG00000198931; ENSPPAG00000005769; ENSPTRG00000008466","Purine metabolism; Metabolic pathways","Neutrophil degranulation; Purine salvage","",10471.7,9888.5,9966.8,9085.2,8850.8,9965.6,1.0869269145855436,0.12025493621634308,0.10393753760004945,0.9832275763276522,0.3439019747934638,0.4635653303151142,2209]
["P07992-1","DNA excision repair protein ERCC-1 [OS=Homo sapiens]",15,3,3,3,297,32.5,6.25,10.09,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ERCC1","ENSG00000012061; ENSPPAG00000043568; ENSPTRG00000011152","Platinum drug resistance; Nucleotide excision repair; Fanconi anemia pathway","HDR through Single Strand Annealing (SSA); Fanconi Anemia Pathway; Dual incision in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER","Male infertility; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum",264.3,238.5,242.9,246.1,246.8,166.7,1.130533656761674,0.1770039427487723,0.35949543825153607,0.44430661614272676,0.5879508073798339,0.23065900891911287,4469]
["P08069","Insulin-like growth factor 1 receptor [OS=Homo sapiens]",3,4,5,3,1367,154.7,5.8,12.45,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;transporter activity;kinase activity;other molecular function","IGF1R","ENSG00000140443","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; Ras signaling pathway; Rap1 signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Oocyte meiosis; Autophagy; Endocytosis; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Focal adhesion; Adherens junction; Signaling pathways regulating pluripotency of stem cells; Long-term depression; Ovarian steroidogenesis; Progesterone-mediated oocyte maturation; Pathways in cancer; Transcriptional misregulation in cancer; Proteoglycans in cancer; Glioma; Prostate cancer; Melanoma; Breast cancer; Hepatocellular carcinoma","Extra-nuclear estrogen signaling; IRS-related events triggered by IGF1R; Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R); SHC-related events triggered by IGF1R","MicroRNAs in cardiomyocyte hypertrophy; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Apoptosis; Focal adhesion; MECP2 and associated Rett syndrome; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Ebola virus pathway in host; Ras signaling; Breast cancer pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Head and neck squamous cell carcinoma; Endochondral ossification; EGFR tyrosine kinase inhibitor resistance; Endochondral ossification with skeletal dysplasias; Insulin signaling; Malignant pleural mesothelioma; Senescence and autophagy in cancer",260.3,260.8,243.6,268.1,282.5,241.7,0.9651647103369937,-0.05115292814489096,0.5246807445315195,0.28010487385608424,0.6846798003536646,0.16451248464085205,5601]
["P08237","ATP-dependent 6-phosphofructokinase, muscle type [OS=Homo sapiens]",48,27,99,24,780,85.1,7.99,319.74,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus","kinase activity;other molecular function","PFKM","ENSG00000152556","Glycolysis / Gluconeogenesis; Pentose phosphate pathway; Fructose and mannose metabolism; Galactose metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; RNA degradation; HIF-1 signaling pathway; AMPK signaling pathway; Thyroid hormone signaling pathway; Glucagon signaling pathway; Central carbon metabolism in cancer","Glycolysis","Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Insulin signaling; Glycolysis and gluconeogenesis",10342.6,10023.3,10673.7,10073.3,9877,9264.2,1.0624724024029166,0.08742536790112335,0.11911740652714865,0.924024770789877,0.3665806839187072,0.43583042286678936,2375]
["P08582-1","Melanotransferrin [OS=Homo sapiens]",10,5,7,5,738,80.2,5.94,23.52,"transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","MELTF","ENSG00000163975","","Post-translational modification: synthesis of GPI-anchored proteins; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","3q29 copy number variation syndrome",515.8,473.9,480.8,398.5,444.5,603.6,1.0165214986865754,0.023640727450744005,0.9061758907113708,0.04278749663741127,0.9389338793889155,0.027364990084909113,7054]
["P08670","Vimentin [OS=Homo sapiens]",82,44,1256,40,466,53.6,5.12,3152.9,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","VIM","ENSG00000026025","Epstein-Barr virus infection; MicroRNAs in cancer","Aggrephagy; Interleukin-4 and Interleukin-13 signaling; Chaperone Mediated Autophagy; Late endosomal microautophagy; Striated Muscle Contraction; RHOBTB1 GTPase cycle; Caspase-mediated cleavage of cytoskeletal proteins","Allograft Rejection; Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Mammary gland development pathway - Puberty (Stage 2 of 4); Apoptosis-related network due to altered Notch3 in ovarian cancer; Striated muscle contraction pathway; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Ciliary landscape; Burn wound healing; CCL18 signaling pathway; T-cell receptor (TCR) signaling pathway",138103.2,137195.1,128759,130907,135923,127700.4,1.0241474421235983,0.03442342891997845,0.4522972705464266,0.34457603305930407,0.6363504813135384,0.1963036230685273,5195]
["P08887-1","Interleukin-6 receptor subunit alpha [OS=Homo sapiens]",2,1,1,1,468,51.5,8.22,2.3,"other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cell component","other molecular function","IL6R","ENSG00000160712","EGFR tyrosine kinase inhibitor resistance; Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor; HIF-1 signaling pathway; PI3K-Akt signaling pathway; JAK-STAT signaling pathway; Hematopoietic cell lineage; Th17 cell differentiation; Non-alcoholic fatty liver disease; Human cytomegalovirus infection; Coronavirus disease; Pathways in cancer","Transcriptional regulation of granulopoiesis; Potential therapeutics for SARS; Interleukin-4 and Interleukin-13 signaling; Interleukin-6 signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation","Pluripotent stem cell differentiation pathway; IL-6 signaling pathway; Hepatitis C and hepatocellular carcinoma; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Nonalcoholic fatty liver disease; Regulatory circuits of the STAT3 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Neuroinflammation and glutamatergic signaling; Senescence and autophagy in cancer; Sudden infant death syndrome (SIDS) susceptibility pathways",96.8,108.8,79.8,154.7,185.5,598.3,0.30410229088971763,-1.717371410242473,0.20322881240896096,0.6920147206835374,0.4618779197441218,0.3354727988759781,3216]
["P09001","39S ribosomal protein L3, mitochondrial [OS=Homo sapiens]",47,10,38,10,348,38.6,9.48,101.96,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL3","ENSG00000114686","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",3564.1,3468.1,3418.2,3648.6,3500.9,4087.2,0.9300239394128168,-0.10466024229288362,0.22156183510510813,{"$f":"-LOG10(AA1091)","v":0.6545050464287587},0.4825373816398198,{"$f":"-LOG10(AC1091)","v":0.31646903670144844},3356]
["P09493-1","Tropomyosin alpha-1 chain [OS=Homo sapiens]",28,10,53,1,284,32.7,4.74,127.27,"cell organization and biogenesis;stress response;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","TPM1","ENSG00000140416; ENSGGOG00000009130; ENSPPAG00000004536; ENSPTRG00000007141","Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; MicroRNAs in cancer; Hypertrophic cardiomyopathy; Dilated cardiomyopathy","Smooth Muscle Contraction; Striated Muscle Contraction","Vitamin D receptor pathway; Striated muscle contraction pathway",74,69.9,92.3,76.2,86.4,75.3,0.9928541403951239,-0.010346307027977557,0.9452322663843262,0.024461461739747104,0.9643638518988051,0.015759077032768083,7164]
["P09543-1","2',3'-cyclic-nucleotide 3'-phosphodiesterase [OS=Homo sapiens]",47,20,86,19,421,47.5,9.07,280.98,"cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;mitochondrion;other cell component","nucleic acid binding activity;other molecular function","CNP","ENSG00000173786; ENSPTRG00000009187","","","Glial cell differentiation; MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation",9715.3,10378.7,9865.5,7974.1,7824.9,8818.6,1.2169951579357858,0.2833234280056871,8.476550165154256E-3,2.071780863436403,0.11043690758843575,0.9568857628085918,561]
["P09651-1","Heterogeneous nuclear ribonucleoprotein A1 [OS=Homo sapiens]",68,24,322,1,372,38.7,9.13,982.14,"RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HNRNPA1; HNRPA1","ENSCANG00000041992; ENSCATG00000043560; ENSG00000135486; ENSMFAG00000031561; ENSMLEG00000044414; ENSMMUG00000012989; ENSMNEG00000042992; ENSPANG00000010434; ENSPPAG00000018027; ENSPTRG00000049417; ENSRBIG00000029387; ENSRROG00000030782","Spliceosome; Amyotrophic lateral sclerosis","mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA","mRNA processing; mRNA Processing",24370,23301.4,20439.5,27543.6,30740.5,37046.8,0.7144682364270137,-0.4850582209600454,0.04009661420491971,1.396892298058142,0.21952520840730946,0.658515601874763,1335]
["P09960-1","leukotriene A-4 hydrolase [OS=Homo sapiens]",49,28,124,28,611,69.2,6.18,365.67,"protein metabolism;other metabolic processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","LTA4H","ENSG00000111144; ENSPTRG00000005321","Arachidonic acid metabolism; Metabolic pathways","Neutrophil degranulation; Biosynthesis of protectins; Synthesis of Leukotrienes (LT) and Eoxins (EX); Biosynthesis of D-series resolvins; Biosynthesis of E-series 18(S)-resolvins; Biosynthesis of aspirin-triggered D-series resolvins; Biosynthesis of E-series 18(R)-resolvins","Eicosanoid synthesis; Eicosanoid metabolism via lipooxygenases (LOX); Prostaglandin and leukotriene metabolism in senescence",17409.7,17957.6,17713.9,15498.6,14364.9,10633.3,1.3107504790501965,0.39039307312736865,0.046976818635444374,1.32811639785757,0.23679556372859514,0.625626438208572,1450]
["P0CAP2-1","DNA-directed RNA polymerase II subunit GRINL1A [OS=Homo sapiens]",22,5,6,5,368,41.7,6.39,18.32,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction","nucleus;other cell component","other molecular function","POLR2M","ENSG00000255529","RNA polymerase","","",415.7,374.7,347.6,453.7,443.1,391.5,0.8833346270278661,-0.17896802813363616,0.14350857816107543,0.8431221383956737,0.39686121747230435,0.4013613396434111,2643]
["P0CG08","Golgi pH regulator B [OS=Homo sapiens]",11,3,12,3,455,52.9,9.28,50.47,"transport;developmental processes;other biological processes","other membranes;ER/Golgi","transporter activity","GPR89B","ENSG00000188092","","","",473.6,406.3,442.8,365.1,387.5,180.3,1.4178368528245255,0.5036915345786251,0.13060371531771983,0.8840444683975942,0.3806150539303087,0.4195140386723001,2508]
["P0DMV8","heat shock 70 kDa protein 1A [OS=Homo sapiens]",57,32,354,17,641,70,5.66,921,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","HSPA1A","ENSG00000204389; ENSG00000215328; ENSG00000234475; ENSG00000235941; ENSG00000237724","Spliceosome; MAPK signaling pathway; Protein processing in endoplasmic reticulum; Endocytosis; Longevity regulating pathway; Antigen processing and presentation; Estrogen signaling pathway; Prion disease; Legionellosis; Toxoplasmosis; Measles; Lipid and atherosclerosis","AUF1 (hnRNP D0) binds and destabilizes mRNA; Neutrophil degranulation; Regulation of HSF1-mediated heat shock response; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase; Viral RNP Complexes in the Host Cell Nucleus","Apoptosis modulation and signaling; Parkin-ubiquitin proteasomal system pathway; Nuclear receptors meta-pathway; NRF2 pathway; MAPK signaling pathway; Apoptosis modulation by HSP70; VEGFA-VEGFR2 signaling pathway",18804.3,17456.3,18467.5,17641.2,18213.1,12665.8,1.1279469745528141,0.17369924739290146,0.31611564934838476,0.5001540038206003,0.5624365338576788,0.2499264768618678,4108]
["P10114","Ras-related protein Rap-2a [OS=Homo sapiens]",50,8,41,4,183,20.6,4.82,124.75,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","RAP2A","ENSG00000125249","","","",665.3,629.4,618.1,533.1,554.3,508.7,1.1984211515569196,0.26113499200758583,5.5284373622409575E-3,2.2573976066443,0.09204407444332383,1.0360041650024483,439]
["P10412","Histone H1.4 [OS=Homo sapiens]",45,17,408,3,219,21.9,11.03,1195.29,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","H1-4","ENSG00000168298","","Formation of Senescence-Associated Heterochromatin Foci (SAHF); Apoptosis induced DNA fragmentation","Pathways affected in adenoid cystic carcinoma; Genotoxicity pathway",21045.8,20028.3,19658.2,19487.2,20849.3,63072.8,0.5873001751293162,-0.7678300268491303,0.3765265932147828,0.42420434515099176,0.5946484161207536,0.22573973354673074,4628]
["P10747-1","T-cell-specific surface glycoprotein CD28 [OS=Homo sapiens]",8,2,6,2,220,25.1,9.39,14.27,"developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","CD28","ENSG00000178562; ENSGGOG00000041735; ENSPPAG00000034998; ENSPTRG00000012833","Cell adhesion molecules; T cell receptor signaling pathway; Intestinal immune network for IgA production; Type I diabetes mellitus; Measles; PD-L1 expression and PD-1 checkpoint pathway in cancer; Autoimmune thyroid disease; Systemic lupus erythematosus; Rheumatoid arthritis; Allograft rejection; Graft-versus-host disease; Viral myocarditis","PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; CD28 dependent PI3K/Akt signaling; CD28 dependent Vav1 pathway; Nef mediated downregulation of CD28 cell surface expression","Allograft Rejection; T cell receptor and co-stimulatory signaling; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Control of immune tolerance by vasoactive intestinal peptide; Selective expression of chemokine receptors during T-cell polarization; Inflammatory response pathway; Cancer immunotherapy by CTLA4 blockade; Modulators of TCR signaling and T cell activation; Prostaglandin signaling; T-cell receptor (TCR) signaling pathway",798.7,806.1,827.5,745,787.5,578.1,1.1524211124798638,0.2046679961822656,0.17166858059268011,0.7653091837199888,0.4286729263928592,0.36787394426980785,2927]
["P10909-1","Clusterin [OS=Homo sapiens]",14,5,10,5,449,52.5,6.27,34.37,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","CLU","ENSG00000120885","Complement and coagulation cascades","Platelet degranulation ; Regulation of Complement cascade; Antimicrobial peptides; Terminal pathway of complement","Male infertility; Complement system in neuronal development and plasticity; Complement and coagulation cascades",746.3,725.1,739.3,558.1,559.1,681.8,1.2288493607559756,0.2973080729031517,0.029828116352650667,1.52537417149477,0.19259160991300683,0.7153626364630497,1132]
["P11169","Solute carrier family 2, facilitated glucose transporter member 3 [OS=Homo sapiens]",4,2,2,2,496,53.9,7.2,4.48,"other metabolic processes;transport","plasma membrane;other membranes;other cell component","transporter activity;other molecular function","SLC2A3","ENSG00000059804","","Neutrophil degranulation; Cellular hexose transport; Vitamin C (ascorbate) metabolism; MECP2 regulates neuronal receptors and channels","Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced HIF-1 survival signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K/AKT/mTOR - VitD3 signaling; Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis",118.8,146.2,122.6,124.1,138,223.9,0.7975308641975309,-0.32638774307806206,0.36816186301018317,0.4339612010086697,0.5917957019444532,0.22782819332980495,4547]
["P11277","Spectrin beta chain, erythrocytic [OS=Homo sapiens]",9,19,54,9,2137,246.3,5.27,150.96,"cell organization and biogenesis","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity","SPTB","ENSG00000070182","","COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins","",955.7,919,931.5,1072.7,1069,1293.3,0.816943231441048,-0.2916922644527279,0.04895844044557937,1.3101724249447393,0.24096783920319167,0.6180409167139974,1485]
["P11279","Lysosome-associated membrane glycoprotein 1 [OS=Homo sapiens]",19,8,56,8,417,44.9,8.75,149.71,"transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","LAMP1","ENSG00000185896","Autophagy; Lysosome; Phagosome; Tuberculosis","Neutrophil degranulation","Senescence and autophagy in cancer",6362.8,6642,6347.7,5392.4,5142.9,3420.5,1.3866994367933045,0.47165512144850186,0.04556542989395904,1.3413645279539999,0.23371068568066433,0.6313214304145558,1425]
["P11717","Cation-independent mannose-6-phosphate receptor [OS=Homo sapiens]",37,74,213,74,2491,274.2,5.94,668.87,"protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","IGF2R","ENSG00000197081","Lysosome; Endocytosis","Neutrophil degranulation; Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; Retrograde transport at the Trans-Golgi-Network","",22647.7,22999.4,22484.4,21247.2,20754,25221,1.0135267813311675,0.019384210939183077,0.841646304931475,0.07487037891393628,0.9001452798864721,0.04568739149270733,6834]
["P11908","ribose-phosphate pyrophosphokinase 2 [OS=Homo sapiens]",54,16,99,7,318,34.7,6.61,304.64,"other metabolic processes","other cell component","kinase activity;other molecular function","PRPS2","ENSG00000101911","Pentose phosphate pathway; Purine metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids","5-Phosphoribose 1-diphosphate biosynthesis","Nucleotide metabolism",6787.7,6555.1,7088.2,5733.5,5548.9,3222.2,1.4085876204790206,0.49424930861796146,0.07425810034774862,1.1292561649811608,0.2978882850942342,0.5259465757341671,1822]
["P12259","Coagulation factor V [OS=Homo sapiens]",2,4,10,4,2224,251.5,6.05,25.4,"stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","F5","ENSG00000198734","Complement and coagulation cascades","COPII-mediated vesicle transport; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Common Pathway of Fibrin Clot Formation; Cargo concentration in the ER","Blood clotting cascade; Complement and coagulation cascades",1189.7,1103.8,1146.8,849.8,919,901.3,1.2884536159694393,0.36564060144637367,1.3628087177707097E-3,2.86556509695065,0.05134416968137174,1.2895088649969029,194]
["P12956","X-ray repair cross-complementing protein 6 [OS=Homo sapiens]",67,39,511,39,609,69.8,6.64,1565.56,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","XRCC6","ENSG00000196419","Non-homologous end-joining","Neutrophil degranulation; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation; IRF3-mediated induction of type I IFN","Non-homologous end joining; DNA repair pathways, full network",51869.7,51872.5,52505.9,51563.2,50782.5,39669.3,1.1002225117065099,0.1377953274515223,0.28499119788113153,0.5451685532219682,0.5361649074165227,0.2707016144749283,3885]
["P13073","Cytochrome c oxidase subunit 4 isoform 1, mitochondrial [OS=Homo sapiens]",36,7,70,7,169,19.6,9.51,154.87,"other metabolic processes;transport;other biological processes","other membranes;cytosol;mitochondrion;nucleus","transporter activity","COX4I1","ENSG00000131143","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly",7619.6,7626.5,8630.7,8249.7,9117.7,8181.7,0.9345456395724312,-0.0976629735846587,0.2842916475243462,0.5462358996742187,0.5358142474872218,0.27098574253293234,3878]
["P13598","Intercellular adhesion molecule 2 [OS=Homo sapiens]",8,2,2,2,275,30.6,7.43,7.3,"cell adhesion","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding","ICAM2","ENSG00000108622","Cell adhesion molecules; Natural killer cell mediated cytotoxicity","Integrin cell surface interactions; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; CD209 (DC-SIGN) signaling","Complement system; Ebola virus pathway in host",428.5,373.9,384,396.1,407.2,325.5,1.0510276399716514,0.07180060985736644,0.5643060187502444,0.24848531762632692,0.7119821665882162,0.14753088424141111,5793]
["P13747","HLA class I histocompatibility antigen, alpha chain E [OS=Homo sapiens]",38,11,40,9,358,40.1,5.95,128.11,"other biological processes","plasma membrane;other membranes","","HLA-E","","","","",2086.6,1992.7,1916.9,1898.5,1966.6,1759.2,1.0661237842931566,0.092374954624406,0.1886374867740507,0.7243719983358841,0.44750126284697717,0.34920573476885175,3081]
["P13796","Plastin-2 [OS=Homo sapiens]",79,45,1261,36,627,70.2,5.43,3790.82,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","LCP1","ENSG00000136167","","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","",146224.6,144925.7,142946.8,137380.8,136450.6,145636.5,1.034875612651171,0.049457372753014546,0.18749708192192116,0.7270054869499641,0.446099014247175,0.35056873642546565,3072]
["P13995","Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [OS=Homo sapiens]",38,9,47,9,350,37.9,8.73,177.98,"other metabolic processes","mitochondrion","other molecular function","MTHFD2","ENSG00000065911","One carbon pool by folate; Metabolic pathways; Biosynthesis of cofactors","Metabolism of folate and pterines","Folate metabolism; One-carbon metabolism; Trans-sulfuration and one-carbon metabolism; Nucleotide metabolism",4586,4179.4,4391.3,4830.6,5119,3691.1,0.9645179499585798,-0.052120007390322375,0.7388794820356266,0.13142639320903618,0.8318653934378304,0.07994694247925747,6492]
["P14174","Macrophage Migration inhibitory factor [OS=Homo sapiens]",32,3,25,3,115,12.5,7.88,55.83,"cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","MIF","ENSG00000240972; ENSG00000276701","Tyrosine metabolism; Phenylalanine metabolism; Metabolic pathways","Neutrophil degranulation; Cell surface interactions at the vascular wall; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","Adipogenesis; Spinal cord injury",2488,2229.9,3017.8,3106.4,3011.1,2404.9,0.9076903219750305,-0.13972791978854762,0.457800498146194,0.33932373909261276,0.6394159833652842,0.19421651194830508,5233]
["P14373","Zinc finger protein RFP [OS=Homo sapiens]",13,5,6,5,513,58.5,6.21,17.27,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","TRIM27","ENSG00000204713; ENSG00000215641; ENSG00000229006; ENSG00000234495; ENSG00000237071","","Regulation of PTEN stability and activity; SUMOylation of ubiquitinylation proteins; Suppression of apoptosis","",364.6,323.5,358.3,445,486.3,537,0.7126609003609616,-0.48871232079787946,0.008873498174736658,2.051905135694429,0.11299024069538367,0.9469590662084296,574]
["P14678-1","Small nuclear ribonucleoprotein-associated proteins B and B' [OS=Homo sapiens]",22,7,33,7,240,24.6,11.19,98.36,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","Snrpb; SNRPB; SNRPN","ENSANAG00000024443; ENSCANG00000019461; ENSCCAG00000026002; ENSG00000125835; ENSLCNG00005019999; ENSMLEG00000022346; ENSMMUG00000010050; ENSNLEG00000029067; ENSOGAG00000016149; ENSPANG00000020362; ENSRROG00000036094; ENSSBOG00000027310","Spliceosome; Systemic lupus erythematosus","snRNP Assembly; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs","mRNA processing",3243.1,3839.5,4548.1,4194.5,3615.8,2313.5,1.148847270787649,0.20018701702418315,0.49636014352978564,0.30420309852708716,0.6655469251622094,0.1768213186708109,5451]
["P14927","Cytochrome b-c1 complex subunit 7 [OS=Homo sapiens]",22,2,4,2,111,13.5,8.78,11.24,"other metabolic processes","other membranes;mitochondrion","","UQCRB","ENSG00000156467","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly",184,167.2,174.9,158.4,140.6,164.2,1.1357944732297065,0.18370179674555293,0.07139860662069887,1.1463102636138314,0.29186376722074275,0.5348198161897573,1788]
["P15121","aldose reductase [OS=Homo sapiens]",72,18,128,16,316,35.8,6.98,425.69,"other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","AKR1B1","ENSG00000085662","Pentose and glucuronate interconversions; Fructose and mannose metabolism; Galactose metabolism; Glycerolipid metabolism; Folate biosynthesis; Metabolic pathways","Pregnenolone biosynthesis; Fructose biosynthesis","Eicosanoid metabolism via cyclooxygenases (COX); Polyol pathway; Metapathway biotransformation Phase I and II",16899.9,19190.9,19767.3,17357.7,15029.1,12368.3,1.2480834586449365,0.3197144096387506,0.09322906925042673,1.0304486515232458,0.3277591472589557,0.48444517897074213,2079]
["P15374","Ubiquitin carboxyl-terminal hydrolase isozyme L3 [OS=Homo sapiens]",45,9,42,9,230,26.2,4.92,127.2,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","UCHL3","ENSG00000118939","","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; UCH proteinases; Neddylation","Proteasome degradation",4471.7,4254.9,4309.6,4776.4,5126.4,5348.8,0.8547431089197199,-0.2264372084277826,0.014510370934491602,1.8383214853745475,0.1399159645912917,0.8541327291226282,758]
["P15498-1","Proto-oncogene vav [OS=Homo sapiens]",45,38,162,36,845,98.3,6.62,478.58,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","enzyme regulator activity;other molecular function","VAV1","ENSG00000141968; ENSPTRG00000010378","Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Focal adhesion; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Yersinia infection; Proteoglycans in cancer; Lipid and atherosclerosis","RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC1 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated phagocytosis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; NRAGE signals death through JNK; G alpha (12/13) signalling events; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Regulation of signaling by CBL; GPVI-mediated activation cascade; Signaling by SCF-KIT; VEGFR2 mediated vascular permeability; Erythropoietin activates RAS; CD28 dependent Vav1 pathway","Prolactin signaling pathway; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL-6 signaling pathway; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; EGF/EGFR signaling pathway; Modulators of TCR signaling and T cell activation; Regulation of actin cytoskeleton; Interferon type I signaling pathways; T-cell receptor (TCR) signaling pathway; EGFR1 signaling pathway; Kit receptor signaling pathway",22539.4,22528.9,22957.5,21633.1,20300.9,16884.7,1.1565335514045703,0.20980711962120024,0.0969294167840476,1.0135444003673246,0.33323476353462084,0.4772496986706296,2126]
["P15924-1","Desmoplakin [OS=Homo sapiens]",30,80,151,80,2871,331.6,6.81,424.21,"cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","DSP","ENSG00000096696","Arrhythmogenic right ventricular cardiomyopathy","Neutrophil degranulation; Formation of the cornified envelope; RND3 GTPase cycle; RND1 GTPase cycle; Apoptotic cleavage of cell adhesion  proteins","Arrhythmogenic right ventricular cardiomyopathy; Lung fibrosis; Epithelial to mesenchymal transition in colorectal cancer",15677.5,16085.6,15773.8,15221.4,15465.3,16655.7,{"$f":"AVERAGE(S1282:U1282)/AVERAGE(V1282:X1282)","v":1.0041083679745852},{"$f":"LOG(Y1282,2)","v":0.00591497994869756},{"$f":"TTEST(V1282:X1282,S1282:U1282,2,2)","v":0.8947011732897732},0.04832199313290364,{"$f":"AA1282*7309/AE1282","v":0.9315343127599647},0.03080114337873596,7020]
["P16035","Metalloproteinase inhibitor 2 [OS=Homo sapiens]",10,2,3,2,220,24.4,7.49,10.74,"developmental processes;other biological processes","non-structural extracellular;extracellular matrix;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","TIMP2","ENSG00000035862","","Neutrophil degranulation; Activation of Matrix Metalloproteinases","Matrix metalloproteinases; Angiogenesis; IL1 and megakaryocytes in obesity; Vitamin D receptor pathway; Burn wound healing; CCL18 signaling pathway",209.5,240.4,244.2,240.2,230.6,427.5,0.772681732160748,-0.3720538049095046,0.35430731966234164,0.45061987545082594,0.5857571136421749,0.23228242847272695,4421]
["P16219","Short-chain specific acyl-CoA dehydrogenase, mitochondrial [OS=Homo sapiens]",6,2,5,2,412,44.3,7.99,12.11,"other metabolic processes","cytoskeleton;mitochondrion;nucleus","other molecular function","ACADS","ENSG00000122971","Fatty acid degradation; Valine, leucine and isoleucine degradation; beta-Alanine metabolism; Propanoate metabolism; Butanoate metabolism; Metabolic pathways; Carbon metabolism; Fatty acid metabolism","Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA","Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation; IL-18 signaling pathway",163.5,233.3,198.9,164.7,150.3,395.4,0.8385416666666669,-0.2540456226065389,0.6650107006842223,0.17717136641009734,0.7848479269014985,0.1052144845356957,6193]
["P16402","Histone H1.3 [OS=Homo sapiens]",47,17,377,5,221,22.3,11.02,1091.22,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity","H1-3","ENSG00000124575","","Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)","",13022,12238.8,11821.2,11628.8,12293.5,17280.9,0.8999786424355389,-0.15203732990942626,0.4919271635563167,0.3080991956213874,0.6627641729830634,0.1786409762579815,5425]
["P16619","C-C motif chemokine 3-like 1 [OS=Homo sapiens]",24,2,10,2,93,10.2,4.89,30.53,"stress response;signal transduction;other biological processes","non-structural extracellular","signal transduction activity or receptor binding","CCL3L1; CCL3L3","ENSG00000276085; ENSG00000277336; ENSG00000277768; ENSG00000277796","Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor; Chemokine signaling pathway; Toll-like receptor signaling pathway; Chagas disease; Human cytomegalovirus infection; Rheumatoid arthritis; Lipid and atherosclerosis","Chemokine receptors bind chemokines; Interleukin-10 signaling","Overview of proinflammatory and profibrotic mediators",1197.1,1171.1,1144.7,1691.6,2014.3,2191.2,0.5956995811500567,-0.7473431501972684,0.005673072601218779,2.246181658510577,0.09276171732059968,1.0326312197585408,447]
["P16949-1","Stathmin [OS=Homo sapiens]",36,6,9,6,149,17.3,5.97,21.91,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity","LOC101348598; Stathmin; STMN1","ENSAMEG00000010298; ENSANAG00000030242; ENSBIXG00000025259; ENSBTAG00000013761; ENSCAFG00000029191; ENSCATG00000016402; ENSCCAG00000028161; ENSCHIG00000023552; ENSCJAG00000009462; ENSCSAG00000000960; ENSFCAG00000040721; ENSG00000117632; ENSGGOG00000026648; ENSLCNG00005009740; ENSMFAG00000041588; ENSMLEG00000037590; ENSMLUG00000010762; ENSMMUG00000000653; ENSMNEG00000044643; ENSNLEG00000009154; ENSOARG00000005764; ENSOGAG00000002109; ENSPANG00000010315; ENSPCTG00005008718; ENSPPAG00000038785; ENSPPYG00000001700; ENSPTRG00000000369; ENSRBIG00000033291; ENSRFEG00010003199; ENSRROG00000019821; ENSSBOG00000029102; ENSSSCG00000026257; ENSSSCG00005028094; ENSSSCG00015059883; ENSSSCG00055018660; ENSSSCG00070026240; ENSSSUG00005019081; ENSTTRG00000012495; ENSUAMG00000025721; ENSUMAG00000012809; ENSVVUG00000011613","MAPK signaling pathway; MicroRNAs in cancer","Nuclear signaling by ERBB4","MAPK signaling pathway; Microtubule cytoskeleton regulation; Retinoblastoma gene in cancer; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; EGF/EGFR signaling pathway; IL-18 signaling pathway; MAPK signaling pathway; MAPK signaling pathway",1435.1,1358.3,1202.1,907.4,893.1,1262.4,1.3044826798132487,0.38347778898984625,0.08878731310754305,1.0516490864851504,0.3212606294569466,0.4931424940478012,2020]
["P17096-1","High mobility group protein HMG-I/HMG-Y [OS=Homo sapiens]",48,4,8,4,107,11.7,10.32,24.83,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","HMGA1; LOC111152215","ENSAMEG00000001061; ENSCAFG00030004107; ENSCAFG00040011381; ENSCANG00000029050; ENSCATG00000042051; ENSCCAG00000024304; ENSCSAG00000009775; ENSECAG00000000734; ENSFCAG00000044104; ENSG00000137309; ENSGGOG00000025804; ENSMLEG00000042857; ENSMMUG00000019529; ENSMNEG00000005671; ENSPCTG00005015441; ENSPTRG00000040884; ENSRBIG00000030072; ENSRFEG00010017624; ENSUAMG00000015725; ENSUMAG00000010910","","Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Formation of Senescence-Associated Heterochromatin Foci (SAHF)","Adipogenesis; Adipogenesis; Pre-implantation embryo; Male infertility; 7q11.23 copy number variation syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Orexin receptor pathway; Senescence and autophagy in cancer; Adipogenesis",1359.2,1175,1009.8,762.8,836.2,978.3,1.3750824506266246,0.4595181259419477,0.05378168825759936,1.269365568987924,0.2521426295540691,0.5983537222927927,1559]
["P17152","Transmembrane protein 11, mitochondrial [OS=Homo sapiens]",14,3,9,3,192,21.5,7.36,21.08,"cell organization and biogenesis","plasma membrane;other membranes;mitochondrion","","TMEM11","ENSG00000178307","","Cristae formation","",1268.6,1435.9,1338.2,1303.4,1190.6,847.1,1.2099907216186285,0.274995984751015,0.1833691761956496,0.7366736661207512,0.44116040448123867,0.35540347376354575,3038]
["P17612","cAMP-dependent protein kinase catalytic subunit alpha [OS=Homo sapiens]",37,15,43,9,351,40.6,8.79,135.85,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","kinase activity;other molecular function","PRKACA","ENSG00000072062; ENSG00000288516","Endocrine resistance; MAPK signaling pathway; Ras signaling pathway; Calcium signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Oocyte meiosis; Autophagy; Longevity regulating pathway; Longevity regulating pathway; Adrenergic signaling in cardiomyocytes; Vascular smooth muscle contraction; Wnt signaling pathway; Hedgehog signaling pathway; Apelin signaling pathway; Tight junction; Gap junction; Platelet activation; Circadian entrainment; Thermogenesis; Long-term potentiation; Retrograde endocannabinoid signaling; Glutamatergic synapse; Cholinergic synapse; Serotonergic synapse; GABAergic synapse; Dopaminergic synapse; Olfactory transduction; Taste transduction; Inflammatory mediator regulation of TRP channels; Insulin signaling pathway; Insulin secretion; GnRH signaling pathway; Ovarian steroidogenesis; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Melanogenesis; Thyroid hormone synthesis; Thyroid hormone signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Regulation of lipolysis in adipocytes; Renin secretion; Aldosterone synthesis and secretion; Relaxin signaling pathway; Cortisol synthesis and secretion; Parathyroid hormone synthesis, secretion and action; Cushing syndrome; Growth hormone synthesis, secretion and action; Endocrine and other factor-regulated calcium reabsorption; Vasopressin-regulated water reabsorption; Salivary secretion; Gastric acid secretion; Bile secretion; Parkinson disease; Prion disease; Cocaine addiction; Amphetamine addiction; Morphine addiction; Alcoholism; Vibrio cholerae infection; Amoebiasis; Human cytomegalovirus infection; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; Chemical carcinogenesis; Dilated cardiomyopathy","Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; MAPK6/MAPK4 signaling; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Interleukin-3, Interleukin-5 and GM-CSF signaling; Factors involved in megakaryocyte development and platelet production; VEGFA-VEGFR2 Pathway; RET signaling; ROBO receptors bind AKAP5; FCGR3A-mediated IL10 synthesis; Triglyceride catabolism; ADORA2B mediated anti-inflammatory cytokines production; Ion homeostasis; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; Regulation of MECP2 expression and activity; PKA activation; PKA activation in glucagon signalling; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; CD209 (DC-SIGN) signaling; Rap1 signalling; HDL assembly; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase; Loss of phosphorylation of MECP2 at T308; PKA-mediated phosphorylation of key metabolic factors","Nicotine effect on dopaminergic neurons; Sterol regulatory element-binding proteins (SREBP) signaling; Follicle stimulating hormone (FSH) signaling pathway; Microtubule cytoskeleton regulation; Dopamine metabolism; Common pathways underlying drug addiction; Complement system; Mesodermal commitment pathway; IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Mesodermal commitment pathway; G protein signaling pathways; MAPK signaling pathway; Cannabinoid receptor signaling; Lipid metabolism pathway; Ras signaling; Hedgehog signaling pathway; Thermogenesis; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Neuroinflammation and glutamatergic signaling; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways; Estrogen signaling pathway",5876.2,5886.5,6019.3,5135,5190.1,3977.9,1.243235684821366,0.31409981939233356,0.04347722007755789,1.3617382323772171,0.22845075596468054,0.6412074004852906,1391]
["P17931","Galectin-3 [OS=Homo sapiens]",6,1,1,1,250,26.1,8.56,3.66,"RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","LGALS3","ENSG00000131981","","Neutrophil degranulation; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; Advanced glycosylation endproduct receptor signaling; RUNX2 regulates genes involved in differentiation of myeloid cells","AGE/RAGE pathway; Spinal cord injury",78.6,82.2,88.4,87.1,78.4,143.9,0.8054298642533938,-0.3121691284250336,0.3879822571506534,0.41118813470928506,0.6013066831030801,0.22090396924836356,4716]
["P18031","Tyrosine-protein phosphatase non-receptor type 1 [OS=Homo sapiens]",46,18,62,18,435,49.9,6.27,198.79,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","PTPN1","ENSG00000196396","Adherens junction; Insulin signaling pathway; Insulin resistance; Chemical carcinogenesis","MECP2 regulates neuronal receptors and channels; Growth hormone receptor signaling; Regulation of IFNG signaling; Regulation of IFNA signaling; Negative regulation of MET activity; Integrin signaling; PTK6 Down-Regulation","Leptin signaling pathway; Prolactin signaling pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Insulin signaling",8494.9,8903.9,8331.8,7986.6,8039.4,9097.7,1.0241564737677968,0.03443615155180595,0.639546222715322,0.19412806174864364,0.7674344675465915,0.11495869936609193,6091]
["P18583-5","Isoform D of Protein SON [OS=Homo sapiens]",24,37,125,6,2459,266.9,5.73,394.66,"","","","SON","","","","",12826.5,12885.2,12374.3,15412.3,15806,14191.3,0.8387213276487792,-0.25373655240132426,0.008864593892912605,2.05234115561941,0.11307385124484856,0.9466378157028269,573]
["P18827","syndecan-1 [OS=Homo sapiens]",16,5,34,5,310,32.4,4.63,131.88,"cell-cell signaling;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SDC1","ENSG00000115884","ECM-receptor interaction; Cell adhesion molecules; Malaria; Proteoglycans in cancer; Fluid shear stress and atherosclerosis","Cell surface interactions at the vascular wall; A tetrasaccharide linker sequence is required for GAG synthesis; HS-GAG biosynthesis; HS-GAG degradation; Defective B4GALT7 causes EDS, progeroid type; Defective B3GAT3 causes JDSSDHD; Defective EXT2 causes exostoses 2; Defective EXT1 causes exostoses 1, TRPS2 and CHDS; Defective B3GALT6 causes EDSP2 and SEMDJL1; Retinoid metabolism and transport; Syndecan interactions; Other interleukin signaling","",3693.5,3730.7,3910.6,4475.8,5044,2149.4,0.9713433654406471,-0.04194672297892571,0.9061662038759777,0.042792139181631765,0.9390569664156416,0.027308061142260635,7053]
["P18850","Cyclic AMP-dependent transcription factor ATF-6 alpha [OS=Homo sapiens]",2,1,1,1,670,74.5,8.22,0,"stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","ATF6","ENSG00000118217","Protein processing in endoplasmic reticulum; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Lipid and atherosclerosis","ATF4 activates genes in response to endoplasmic reticulum  stress; ATF6 (ATF6-alpha) activates chaperone genes","Sterol regulatory element-binding proteins (SREBP) signaling; Alzheimer's disease and miRNA effects; Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling pathway; Unfolded protein response; Alzheimer's disease",35.4,39.3,39,36.4,37.6,85,0.7150943396226415,-0.48379451127946993,0.40014303342875107,0.3977847398590861,0.6080343932080544,0.21607185434894485,4810]
["P19388","DNA-directed RNA polymerases I, II, and III subunit RPABC1 [OS=Homo sapiens]",21,4,11,4,210,24.5,5.95,29.4,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","POLR2E","ENSG00000099817","RNA polymerase; Cytosolic DNA-sensing pathway; Huntington disease","mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; RNA Polymerase I Promoter Escape; Inhibition of DNA recombination at telomere; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Viral Messenger RNA Synthesis; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM","Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway",994.8,1030.3,1339.2,1571.6,1482.2,1502.5,0.738384215262384,-0.4375563826486479,0.02430129975675377,1.6143704975090887,0.1770869391047989,0.7518134686455339,1003]
["P19397","Leukocyte surface antigen CD53 [OS=Homo sapiens]",13,4,10,4,219,24.3,7.52,23.32,"signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","CD53","ENSG00000143119","","Neutrophil degranulation","",1169.5,1273.2,1252.2,1157.8,981.6,2309.8,0.8304639036231231,-0.2680106325343278,0.5796519082564724,0.23683273006779043,0.7227355505708899,0.14102058228623418,5862]
["P19784","casein kinase II subunit alpha' [OS=Homo sapiens]",51,14,25,13,350,41.2,8.56,89.99,"cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","CSNK2A2","ENSG00000070770","Ribosome biogenesis in eukaryotes; NF-kappa B signaling pathway; Mitophagy; Wnt signaling pathway; Adherens junction; Alzheimer disease; Prion disease; Pathways of neurodegeneration; Measles; PD-L1 expression and PD-1 checkpoint pathway in cancer","ROS sensing by NFE2L2; Regulation of PTEN stability and activity; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of TP53 Activity through Phosphorylation; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Receptor Mediated Mitophagy; Condensation of Prometaphase Chromosomes; Synthesis of PC","Alzheimer's disease and miRNA effects; Allograft Rejection; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Malignant pleural mesothelioma; Alzheimer's disease",2123.2,2275.3,2215.1,1917.2,1925.8,2333.4,1.070785570882715,0.0986696035270709,0.369562196945061,0.4323124597945271,0.5920934014623961,0.22760977885118383,4562]
["P20036","HLA class II histocompatibility antigen, DP alpha 1 chain [OS=Homo sapiens]",18,3,4,3,260,29.4,5.21,16,"stress response;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","HLA-DPA1","ENSG00000168384; ENSG00000206291; ENSG00000224103; ENSG00000228163; ENSG00000229685; ENSG00000231389; ENSG00000235844; ENSG00000236177","Phagosome; Cell adhesion molecules; Antigen processing and presentation; Hematopoietic cell lineage; Th1 and Th2 cell differentiation; Th17 cell differentiation; Intestinal immune network for IgA production; Type I diabetes mellitus; Leishmaniasis; Toxoplasmosis; Staphylococcus aureus infection; Tuberculosis; Influenza A; Human T-cell leukemia virus 1 infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Asthma; Autoimmune thyroid disease; Inflammatory bowel disease; Systemic lupus erythematosus; Rheumatoid arthritis; Allograft rejection; Graft-versus-host disease; Viral myocarditis","Downstream TCR signaling; Generation of second messenger molecules; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling","Allograft Rejection; Ebola virus pathway in host",410.9,343.2,393.1,298.3,325,639.9,0.9081697276757441,-0.13896614715833228,0.7463218301229103,0.12707385495837828,0.8372780132568459,0.07713031312300885,6515]
["P20073-1","Annexin A7 [OS=Homo sapiens]",34,16,117,16,488,52.7,5.68,287.16,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","ANXA7","ENSG00000138279","Amyotrophic lateral sclerosis","","",11114,11671.7,10970.6,11141.7,9707.5,10186.5,1.0876603395444602,0.1212280943080261,0.12749044433604606,0.8945223652507835,0.376040216970202,0.4247657054068553,2478]
["P20340-2","Isoform 2 of Ras-related protein Rab-6A [OS=Homo sapiens]",45,11,48,1,208,23.5,5.54,102.09,"","","","RAB6A","","","","",222.9,236.7,219.7,178.9,162.4,257,1.1353835868293498,0.1831797911934078,0.4138234406014653,0.3831849128110717,0.6158899465192649,0.21049688505870265,4911]
["P20701-1","Integrin alpha-L [OS=Homo sapiens]",11,8,11,8,1170,128.7,5.63,35.18,"cell adhesion;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","ITGAL","ENSG00000005844","Rap1 signaling pathway; Cell adhesion molecules; Neutrophil extracellular trap formation; Natural killer cell mediated cytotoxicity; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Malaria; Staphylococcus aureus infection; Human T-cell leukemia virus 1 infection; Epstein-Barr virus infection; Rheumatoid arthritis; Viral myocarditis","Neutrophil degranulation; Integrin cell surface interactions; Cell surface interactions at the vascular wall; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; RUNX3 Regulates Immune Response and Cell Migration","Integrin-mediated cell adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Acute viral myocarditis; Cells and molecules involved in local acute inflammatory response ; Overview of leukocyte-intrinsic Hippo pathway functions; CCL18 signaling pathway",1264.1,1181,1246.7,1152.1,1154.8,626.2,1.258668303160479,0.33189813974128823,0.22747718997194907,0.6430621452309047,0.48771803505572775,0.3118311845758229,3409]
["P20810-6","Isoform 6 of Calpastatin [OS=Homo sapiens]",65,41,192,1,791,84.9,5.36,471.87,"","","","CAST","","","","",20120,19262.1,20103.6,21697.8,22478.2,21107.5,0.9111904233075738,-0.13417551061490657,0.016636097524330946,1.7789485423733076,0.1493774407927947,0.8257149853785359,814]
["P21333-2","Isoform 2 of Filamin-A [OS=Homo sapiens]",58,114,509,103,2639,279.8,6.05,1811.48,"","","","FLNA","","","","",61745.3,63096.4,58960.6,48158.1,49246.1,54612.5,1.2090928167760517,0.273924998236903,0.010551081550767252,1.9767030202283613,0.12260390310740514,0.9114957037896573,629]
["P21359-1","Neurofibromin [OS=Homo sapiens]",3,6,6,6,2839,319.2,7.39,17.78,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","NF1","ENSG00000196712","EGFR tyrosine kinase inhibitor resistance; MAPK signaling pathway; Ras signaling pathway","Regulation of RAS by GAPs; RAS signaling downstream of NF1 loss-of-function variants","Pilocytic astrocytoma; Glioblastoma signaling pathways; Aryl hydrocarbon receptor Netpath; MECP2 and associated Rett syndrome; MAPK signaling pathway; Ras signaling; Transcription co-factors SKI and SKIL protein partners; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Melanoma; EGFR tyrosine kinase inhibitor resistance",310.4,272.5,318.2,286.4,312.5,522.7,0.8034058487874465,-0.315799130658663,0.38891724002793887,0.4101428049033223,0.6010987750823018,0.2210541570347756,4729]
["P21964-1","Catechol O-methyltransferase [OS=Homo sapiens]",44,9,29,9,271,30,5.47,77.17,"other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","COMT","ENSG00000093010","Steroid hormone biosynthesis; Tyrosine metabolism; Metabolic pathways; Dopaminergic synapse","Potential therapeutics for SARS; Methylation; Enzymatic degradation of dopamine by COMT; Enzymatic degradation of Dopamine by monoamine oxidase","Dopamine metabolism; MTHFR deficiency; 22q11.2 copy number variation syndrome; Biogenic amine synthesis; Estrogen metabolism; Metapathway biotransformation Phase I and II; Methylation pathways",3409.3,3534.3,3344.8,3229.1,3047.8,2946,1.1155276539916947,0.15772627851451362,0.023568340894404734,1.6276709887852108,0.17365020523911714,0.7603246990554166,992]
["P22304","iduronate 2-sulfatase [OS=Homo sapiens]",9,3,6,3,550,61.8,5.45,24.23,"other metabolic processes","other cytoplasmic organelle","other molecular function","IDS","ENSG00000010404","Glycosaminoglycan degradation; Metabolic pathways; Lysosome","HS-GAG degradation; CS/DS degradation; MPS II - Hunter syndrome","Glycosaminoglycan degradation",230.3,223.3,221.1,212.4,249.1,432.3,0.7548668605952115,-0.4057058828960371,0.3437264847465397,0.4637870033991914,0.5787368986437362,0.23751882735391833,4341]
["P22392-2","Isoform 3 of Nucleoside diphosphate kinase B [OS=Homo sapiens]",81,15,248,2,267,30.1,8.92,730.63,"","","","NME2","","","","",38061.4,39195.6,37741.5,42051.2,38268.9,30943.6,1.0335671022984136,0.04763205592402495,0.7243693127657351,0.14003995645129974,0.8209668641657246,0.08567437150466861,6449]
["P22695","Cytochrome b-c1 complex subunit 2, mitochondrial [OS=Homo sapiens]",48,17,119,17,453,48.4,8.63,367.02,"protein metabolism;other metabolic processes;other biological processes","other membranes;mitochondrion;nucleus","other molecular function","UQCRC2","ENSG00000140740","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly",13838.9,14399.2,13859.8,12580.4,11553.9,12864,1.1378333599111308,0.1862892848558194,0.017848864837826908,1.7483893991789243,0.15438740011796082,0.8113881462446436,845]
["P23229-1","integrin alpha-6 [OS=Homo sapiens]",2,2,2,2,1130,126.5,6.61,6.6,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","ITGA6","ENSG00000091409","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Cell adhesion molecules; Hematopoietic cell lineage; Regulation of actin cytoskeleton; Toxoplasmosis; Human papillomavirus infection; Pathways in cancer; Small cell lung cancer; Hypertrophic cardiomyopathy; Arrhythmogenic right ventricular cardiomyopathy; Dilated cardiomyopathy","Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; Syndecan interactions; Laminin interactions; Basigin interactions; Type I hemidesmosome assembly","Integrin-mediated cell adhesion; Arrhythmogenic right ventricular cardiomyopathy; Alpha 6 beta 4 signaling pathway; Mammary gland development pathway - Embryonic development (Stage 1 of 4); Focal adhesion; Regulation of apoptosis by parathyroid hormone-related protein; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ebola virus pathway in host; Small cell lung cancer; Malignant pleural mesothelioma",104.3,109.2,107.4,127.8,131.9,155.5,0.7728805394990365,-0.37168265407607365,0.022907672785172042,1.640019029007683,0.1719016225737397,0.7647200240023256,974]
["P23284","peptidyl-prolyl cis-trans isomerase B [OS=Homo sapiens]",64,18,453,16,216,23.7,9.41,1131.48,"protein metabolism;other metabolic processes;developmental processes;other biological processes","ER/Golgi;nucleus;other cell component","other molecular function","PPIB","ENSG00000166794","","Collagen biosynthesis and modifying enzymes","Prolactin signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta",69760,69589.5,69415.4,68583.8,66200.7,65807.1,1.0407459734106512,0.057617976780583474,0.03551559903691501,1.4495808557425216,0.20833347781766595,0.6812409361816995,1246]
["P23434","Glycine cleavage system H protein, mitochondrial [OS=Homo sapiens]",39,3,11,3,173,18.9,4.88,37.11,"protein metabolism;other metabolic processes","mitochondrion;other cell component","other molecular function","GCSH","ENSG00000140905","Glycine, serine and threonine metabolism; Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Carbon metabolism","Glycine degradation","",893.7,887.3,920.9,931.4,933.5,597,1.097485681790487,0.1342021179432244,0.5155506298719162,0.28772867820922626,0.6793148645635183,0.16792888220408878,5547]
["P23468-1","Receptor-type tyrosine-protein phosphatase delta [OS=Homo sapiens]",2,2,2,2,1912,214.6,6.57,8.19,"cell adhesion;cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","PTPRD","ENSG00000153707; ENSG00000282932","","Synaptic adhesion-like molecules; Receptor-type tyrosine-protein phosphatases","",42.5,30.8,35.7,32.4,41.1,51,0.8755020080321285,-0.19181760729115455,0.4617906042764115,0.3355549076085768,0.6413124694387785,0.19293031574188138,5263]
["P23634-1","Plasma membrane calcium-transporting ATPase 4 [OS=Homo sapiens]",21,20,33,10,1241,137.8,6.6,122.21,"stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","transporter activity;enzyme regulator activity;other molecular function","ATP2B4","ENSG00000058668","Calcium signaling pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Adrenergic signaling in cardiomyocytes; Aldosterone synthesis and secretion; Endocrine and other factor-regulated calcium reabsorption; Salivary secretion; Pancreatic secretion; Mineral absorption","Ion homeostasis; Ion transport by P-type ATPases; Reduction of cytosolic Ca++ levels","Vitamin D-sensitive calcium signaling in depression",1037.5,910,937.2,769.9,845.3,698.4,1.2468447441217152,0.3182818333869859,0.029573211446262904,1.5291015115354294,0.19247604849575742,0.7156233059129142,1123]
["P24539","ATP synthase F(0) complex subunit B1, mitochondrial [OS=Homo sapiens]",43,12,65,12,256,28.9,9.36,184.57,"other metabolic processes;transport","other membranes;mitochondrion;nucleus","transporter activity","ATP5PB","ENSG00000116459","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation",7013.4,8208.7,7665,6015.5,6791.4,6791.5,1.1678045146542573,0.2237987936164855,0.06398875101108517,1.1938963666911595,0.2728668501400359,0.5640492223943658,1714]
["P24752","Acetyl-CoA acetyltransferase, mitochondrial [OS=Homo sapiens]",64,25,217,25,427,45.2,8.85,726.81,"other metabolic processes;stress response;developmental processes;other biological processes","mitochondrion","other molecular function","ACAT1","ENSG00000075239","Fatty acid degradation; Valine, leucine and isoleucine degradation; Lysine degradation; Tryptophan metabolism; Pyruvate metabolism; Glyoxylate and dicarboxylate metabolism; Butanoate metabolism; Terpenoid backbone biosynthesis; Metabolic pathways; Carbon metabolism; Fatty acid metabolism; Fat digestion and absorption","Branched-chain amino acid catabolism; Utilization of Ketone Bodies; Synthesis of Ketone Bodies","Fatty acid beta-oxidation; Ketone bodies synthesis and degradation; Tryptophan metabolism; SARS-CoV-2 and COVID-19 pathway",26291.6,26593.5,28297.1,25531.4,24854.7,34794.1,0.9530642097576665,-0.06935468035509354,0.7041833145972067,0.15231426961546693,0.8095117720023568,0.09177683131024801,6358]
["P25440-1","Bromodomain-containing protein 2 [OS=Homo sapiens]",3,2,2,2,801,88,9.09,5.99,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","kinase activity;other molecular function","BRD2","ENSG00000204256; ENSG00000215077; ENSG00000234507; ENSG00000234704; ENSG00000235307; ENSGGOG00000043461","","RUNX3 regulates p14-ARF","",166.3,173.8,153.1,679.3,697.2,375.8,0.2814586543400103,-1.829005085759768,0.015890015957860628,1.7988756666436378,0.14590468170352178,0.8359307724973339,796]
["P25786-1","Proteasome subunit alpha type-1 [OS=Homo sapiens]",64,17,151,17,263,29.5,6.61,439.06,"protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","PSMA1","ENSCANG00000029071; ENSCATG00000014932; ENSCJAG00000009850; ENSCPOG00000015226; ENSG00000129084; ENSGGOG00000001416; ENSHGLG00000008245; ENSMFAG00000036829; ENSMLEG00000030594; ENSMMUG00000016446; ENSMNEG00000005235; ENSOCUG00000000439; ENSPANG00000016448; ENSPPYG00000003466; ENSPTRG00000003385; ENSRBIG00000037598; ENSRROG00000037748; ENSSSCG00000013391; ENSSTOG00000006270; ENSTSYG00000003869","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration","ER-Phagosome pathway; MAPK6/MAPK4 signaling; Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Downstream TCR signaling; UCH proteinases; Regulation of expression of SLITs and ROBOs; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease",16001.2,15420.8,15473.6,16137.9,16086.5,14506.1,1.0035330244700997,0.005088093985322364,0.9273113696045892,0.03277441537473361,0.9525957555080734,0.021091357911063778,7115]
["P26006","Integrin alpha-3 [OS=Homo sapiens]",1,1,1,1,1051,116.5,6.77,1.82,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","ITGA3","ENSG00000005884","PI3K-Akt signaling pathway; Focal adhesion; ECM-receptor interaction; Hematopoietic cell lineage; Regulation of actin cytoskeleton; Human papillomavirus infection; Pathways in cancer; Small cell lung cancer; Hypertrophic cardiomyopathy; Arrhythmogenic right ventricular cardiomyopathy; Dilated cardiomyopathy","Integrin cell surface interactions; Laminin interactions; MET activates PTK2 signaling; Basigin interactions","Integrin-mediated cell adhesion; Arrhythmogenic right ventricular cardiomyopathy; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ebola virus pathway in host; Small cell lung cancer; Nephrotic syndrome; Genes controlling nephrogenesis; Malignant pleural mesothelioma",75.4,74.3,70.3,65.1,65.7,93.6,0.9803921568627451,-0.028569152196770954,0.8851224056546655,0.05299666554580394,0.9260463302218651,0.03336728496345895,6986]
["P26358-1","DNA (cytosine-5)-methyltransferase 1 [OS=Homo sapiens]",36,45,110,1,1616,183.1,7.75,300.92,"cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DNMT1","ENSG00000130816","Cysteine and methionine metabolism; Metabolic pathways; MicroRNAs in cancer","NoRC negatively regulates rRNA expression; PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; SUMOylation of DNA methylation proteins","Trans-sulfuration pathway; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration and one-carbon metabolism; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; MTHFR deficiency",398.5,342.9,398.2,622.5,699,270,0.7160540370719446,-0.4818596301994324,0.321937586559689,0.4922283160061275,0.5663157208579463,0.2469413822422843,4155]
["P26373-1","60S ribosomal protein L13 [OS=Homo sapiens]",39,10,37,10,211,24.2,11.65,99.04,"protein metabolism;other metabolic processes;developmental processes","cytosol;ER/Golgi;translational apparatus;nucleus","other molecular function","RPL13","ENSG00000167526","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",5474.1,4881.1,6476.7,5994.4,6414.3,5247.7,0.9533030515846945,-0.06899318031446601,0.6588286261756702,0.18122753894970642,0.7804503125961059,0.10765474109897515,6170]
["P26885","Peptidyl-prolyl cis-trans isomerase FKBP2 [OS=Homo sapiens]",44,4,14,4,142,15.6,9.13,41.59,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","FKBP2","ENSG00000173486","","","Complement system",1594.2,1460,1507.1,1422,1491.2,2248,0.8837673409284662,-0.1782614767038745,0.4962283920073718,0.30431839093165186,0.6654923517764918,0.17685693132432134,5450]
["P27540","Aryl hydrocarbon receptor nuclear translocator [OS=Homo sapiens]",4,3,4,3,789,86.6,6.54,8.99,"stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","ARNT","ENSG00000143437","HIF-1 signaling pathway; Cushing syndrome; Pathways in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Renal cell carcinoma","PPARA activates gene expression; Endogenous sterols; Xenobiotics; Aryl hydrocarbon receptor signalling; Regulation of gene expression by Hypoxia-inducible Factor","Angiogenesis; Aryl hydrocarbon receptor Netpath; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling pathway; Clear cell renal cell carcinoma pathways; Type 2 papillary renal cell carcinoma",412.9,378.8,375.4,386.6,382.1,407.9,0.9919258881523032,-0.01169576136124316,0.8364463484987967,0.07756191040771533,0.8972096215406083,0.047106077755600974,6814]
["P27695","DNA-(apurinic or apyrimidinic site) lyase [OS=Homo sapiens]",61,17,74,17,318,35.5,8.12,255.72,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytoskeleton;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component","nucleic acid binding activity;other molecular function","APEX1","ENSG00000100823","Base excision repair","Displacement of DNA glycosylase by APEX1; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Abasic sugar-phosphate removal via the single-nucleotide replacement pathway","Thyroid stimulating hormone (TSH) signaling pathway; Spinal cord injury; Base excision repair; DNA repair pathways, full network",8574.9,7596.2,8805,8739.9,9806.9,6166.9,1.0106175926712715,0.015237199494275282,0.9426336702837602,0.02565705157269206,0.9627877999027395,0.016469421584054435,7156]
["P27986","Phosphatidylinositol 3-kinase regulatory subunit alpha [OS=Homo sapiens]",16,10,16,9,724,83.5,6.16,43.18,"cell adhesion;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","PIK3R1","ENSG00000145675","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; Platinum drug resistance; ErbB signaling pathway; Ras signaling pathway; Rap1 signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Phosphatidylinositol signaling system; Sphingolipid signaling pathway; Phospholipase D signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Apoptosis; Longevity regulating pathway; Longevity regulating pathway; Cellular senescence; Axon guidance; VEGF signaling pathway; Osteoclast differentiation; Focal adhesion; Signaling pathways regulating pluripotency of stem cells; Platelet activation; Neutrophil extracellular trap formation; Toll-like receptor signaling pathway; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; TNF signaling pathway; Leukocyte transendothelial migration; Neurotrophin signaling pathway; Cholinergic synapse; Inflammatory mediator regulation of TRP channels; Regulation of actin cytoskeleton; Insulin signaling pathway; Progesterone-mediated oocyte maturation; Estrogen signaling pathway; Prolactin signaling pathway; Thyroid hormone signaling pathway; Regulation of lipolysis in adipocytes; Relaxin signaling pathway; GnRH secretion; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Aldosterone-regulated sodium reabsorption; Carbohydrate digestion and absorption; Alzheimer disease; Spinocerebellar ataxia; Prion disease; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection; Chagas disease; Amoebiasis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Pancreatic cancer; Endometrial cancer; Glioma; Prostate cancer; Melanoma; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Central carbon metabolism in cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Diabetic cardiomyopathy; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Signaling by FGFR1 in disease; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; G alpha (q) signalling events; RAC1 GTPase cycle; VEGFA-VEGFR2 Pathway; RHOC GTPase cycle; CDC42 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; RAF/MAP kinase cascade; PI3K Cascade; PI-3K cascade:FGFR4; Signaling by FGFR4 in disease; Downstream TCR signaling; RND2 GTPase cycle; RHOF GTPase cycle; Extra-nuclear estrogen signaling; RHOV GTPase cycle; Signaling by ALK fusions and activated point mutants; RHOU GTPase cycle; Synthesis of PIPs at the plasma membrane; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Regulation of signaling by CBL; Nephrin family interactions; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; Costimulation by the CD28 family; CD28 dependent PI3K/Akt signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; RND3 GTPase cycle; RND1 GTPase cycle; Interleukin-4 and Interleukin-13 signaling; PI3K events in ERBB4 signaling; PI3K events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; GAB1 signalosome; Signaling by cytosolic FGFR1 fusion mutants; PI-3K cascade:FGFR1; PI-3K cascade:FGFR2; Signaling by FGFR2 in disease; PI-3K cascade:FGFR3; Signaling by FGFR3 point mutants in cancer; FLT3 Signaling; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FGFR3 fusions in cancer; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants; GP1b-IX-V activation signalling; MET activates PI3K/AKT signaling; Activated NTRK3 signals through PI3K; Activated NTRK2 signals through PI3K","IL-5 signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase (AMPK) signaling; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Apoptosis; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; IL-6 signaling pathway; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; Ebola virus pathway in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Overview of interferons-mediated signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; IL-18 signaling pathway; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; Modulators of TCR signaling and T cell activation; Orexin receptor pathway; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; Interferon type I signaling pathways; Notch signaling pathway (Netpath); ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway",1691.4,1641,1643.1,1477,1613.2,1440.8,1.0981019642463032,0.1350120219957892,0.0544492786319415,1.264007869594937,0.25396922624177437,0.5952189041795543,1567]
["P28072","Proteasome subunit beta type-6 [OS=Homo sapiens]",31,7,35,7,239,25.3,4.92,93.1,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","PSMB6","ENSG00000142507","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration","FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease",3297.7,3714.1,4145.3,3397.3,3005.1,2059.3,1.318541191486344,0.39894264198352286,0.12636911664223377,0.8983590503468657,0.37576561169165446,0.42508296701332804,2458]
["P28288","ATP-binding cassette sub-family D member 3 [OS=Homo sapiens]",22,11,28,11,659,75.4,9.36,86.64,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ABCD3","ENSG00000117528","ABC transporters; Peroxisome","RHOA GTPase cycle; RHOC GTPase cycle; Class I peroxisomal membrane protein import; ABC transporters in lipid homeostasis","Nuclear receptors in lipid metabolism and toxicity; Fragile X syndrome",1937.6,2020.5,1829.6,1780.8,1746.5,2376,0.9804177324547287,-0.02853151695234897,0.8644189499781785,0.06327572098737802,0.913803602168138,0.03914713430979306,6914]
["P28347","Transcriptional enhancer factor TEF-1 [OS=Homo sapiens]",10,2,2,2,426,47.9,8.15,5.03,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TEAD1","ENSG00000187079","Hippo signaling pathway; Hippo signaling pathway","YAP1- and WWTR1 (TAZ)-stimulated gene expression; EGR2 and SOX10-mediated initiation of Schwann cell myelination; RUNX3 regulates YAP1-mediated transcription","Mesodermal commitment pathway; Mesodermal commitment pathway; miR-509-3p alteration of YAP1/ECM axis; Transcription co-factors SKI and SKIL protein partners; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Overview of leukocyte-intrinsic Hippo pathway functions; Malignant pleural mesothelioma",73.8,58.1,106.3,75.2,89.3,51.8,1.1012482662968097,0.13913974790213493,0.7045575960060573,0.15208349850185196,0.8095600486100099,0.09175093219441137,6361]
["P28702","Retinoic acid receptor RXR-beta [OS=Homo sapiens]",12,4,6,4,533,56.9,8.18,23.05,"signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RXRB","ENSG00000204231; ENSG00000206289; ENSG00000227322; ENSG00000228333; ENSG00000231321; ENSG00000235712","PPAR signaling pathway; Th17 cell differentiation; Thyroid hormone signaling pathway; Adipocytokine signaling pathway; Parathyroid hormone synthesis, secretion and action; Pathways in cancer; Transcriptional misregulation in cancer; Chemical carcinogenesis; Thyroid cancer; Small cell lung cancer; Non-small cell lung cancer; Gastric cancer; Lipid and atherosclerosis","NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; PPARA activates gene expression; Nuclear Receptor transcription pathway; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis; Signaling by Retinoic Acid; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose; NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake ; NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis","Vitamin D metabolism; Nuclear receptors; PPAR signaling pathway; Non-small cell lung cancer; Non-genomic actions of 1,25 dihydroxyvitamin D3; Small cell lung cancer; IL-18 signaling pathway; Vitamin A and carotenoid metabolism",553.1,487.1,452.5,627.3,661.4,618.3,0.7827477713686419,-0.353380599143967,0.012888231617387788,1.8898066677122431,0.1326761759035033,0.8772070545473455,710]
["P29218-1","Inositol monophosphatase 1 [OS=Homo sapiens]",35,8,29,8,277,30.2,5.26,96.42,"other metabolic processes;signal transduction","cytosol;other cell component","other molecular function","IMPA1","ENSG00000133731","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of IP2, IP, and Ins in the cytosol","Integrated breast cancer pathway",2257.2,2256.2,2290.4,2174.2,2075.2,1677.9,1.1478750864643261,0.1989656542578671,0.12707955626204837,0.8959243103170358,0.37558612079228126,0.42529046479436006,2473]
["P29466-1","caspase-1 [OS=Homo sapiens]",45,15,58,15,404,45.1,5.91,200.9,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;other cell component","enzyme regulator activity;other molecular function","CASP1","ENSG00000137752","Necroptosis; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; Amyotrophic lateral sclerosis; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Legionellosis; Yersinia infection; Influenza A; Coronavirus disease; Lipid and atherosclerosis","The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; NOD1/2 Signaling Pathway; TP53 Regulates Transcription of Caspase Activators and Caspases; The AIM2 inflammasome; Pyroptosis; Interleukin-37 signaling; Interleukin-1 processing; The IPAF inflammasome","Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis modulation and signaling; Parkin-ubiquitin proteasomal system pathway; Amyotrophic lateral sclerosis (ALS); Apoptosis; Cytosolic DNA-sensing pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Malignant pleural mesothelioma; Prostaglandin signaling",5448.4,5327.2,5368,5615.7,5708.6,4189.2,1.04061623747059,0.05743812399319722,0.6920113388991571,0.15988678938574188,0.80093600570292,0.09640218239311844,6315]
["P29597","Non-receptor tyrosine-protein kinase TYK2 [OS=Homo sapiens]",4,6,7,5,1187,133.6,7.15,21.06,"protein metabolism;other metabolic processes;stress response;signal transduction","other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","TYK2","ENSG00000105397","Necroptosis; Osteoclast differentiation; NOD-like receptor signaling pathway; JAK-STAT signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease","Potential therapeutics for SARS; Interleukin-4 and Interleukin-13 signaling; Interleukin-10 signaling; Interleukin-6 signaling; Regulation of IFNA signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; IL-6-type cytokine receptor ligand interactions; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-12 signaling; Interleukin-23 signaling; Interleukin-27 signaling; Other interleukin signaling","Type III interferon signaling; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; IL-6 signaling pathway; IL-4 signaling pathway; Immune response to tuberculosis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Overview of interferons-mediated signaling pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Interferon type I signaling pathways",627.6,678.7,616.9,705.7,732.4,1347.3,0.6904573849357365,-0.5343757208662117,0.24375421411553613,0.6130478673163875,0.5028505647672745,0.2985610577655917,3543]
["P30041","Peroxiredoxin-6 [OS=Homo sapiens]",73,18,185,18,224,25,6.38,666,"other metabolic processes;stress response;other biological processes","non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PRDX6","ENSG00000117592","Glutathione metabolism; Metabolic pathways","Neutrophil degranulation; Detoxification of Reactive Oxygen Species","Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling pathway",23280.4,23024.3,24579.8,23336.3,23487.2,18963.7,1.0774816377654013,0.10766328339277524,0.3371738373210171,0.4721461314017624,0.57472098343734,0.24054294620250305,4288]
["P30085-1","UMP-CMP kinase [OS=Homo sapiens]",47,10,43,10,196,22.2,5.57,139.27,"other metabolic processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","CMPK1","ENSG00000162368","Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors","Interconversion of nucleotide di- and triphosphates","Pyrimidine metabolism",5842.9,5515.8,6653.4,6616.8,6732.5,5424.5,0.9594275000266328,-0.059754302853221954,0.6613855946607188,0.17954526849018798,0.7825914378136949,0.10646490794390887,6177]
["P30154","Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [OS=Homo sapiens]",26,13,56,6,601,66.2,4.94,165.5,"protein metabolism;other metabolic processes;other biological processes","other membranes;other cell component","enzyme regulator activity","PPP2R1B","ENSG00000137713","mRNA surveillance pathway; Sphingolipid signaling pathway; Oocyte meiosis; PI3K-Akt signaling pathway; AMPK signaling pathway; Adrenergic signaling in cardiomyocytes; TGF-beta signaling pathway; Hippo signaling pathway; Tight junction; Dopaminergic synapse; Long-term depression; Chagas disease; Hepatitis C; Human papillomavirus infection","Regulation of TP53 Degradation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; DARPP-32 events; Cyclin A/B1/B2 associated events during G2/M transition; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Cyclin D associated events in G1; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; S33 mutants of beta-catenin aren't phosphorylated; S37 mutants of beta-catenin aren't phosphorylated; S45 mutants of beta-catenin aren't phosphorylated; T41 mutants of beta-catenin aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; MASTL Facilitates Mitotic Progression; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated","Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Netrin-UNC5B signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome",1240.2,1279.3,1215.5,1388.8,1393.9,1137.8,0.9526846065552864,-0.06992941681577959,0.514423877845712,{"$f":"-LOG10(AA1603)","v":0.2886788811103548},0.678564180323824,{"$f":"-LOG10(AC1603)","v":0.16840906938628566},5541]
["P30414","NK-tumor recognition protein [OS=Homo sapiens]",8,12,20,12,1462,165.6,9.99,53.52,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","NKTR","ENSG00000114857","","","",2324.3,2202.2,2132.6,2093.4,2149.7,2438.8,0.9965877968841198,-4.931186411322749E-3,0.9528430063866155,0.020978649284634398,0.9699623305960686,0.013245131642961757,7180]
["P30479","HLA class I histocompatibility antigen, B-41 alpha chain [OS=Homo sapiens]",40,12,106,2,362,40.5,6.54,299.71,"other biological processes","plasma membrane;other membranes","","HLA-B","","","","",3259.1,3245.2,3344.5,2762.2,2901.7,4118.5,1.0067877003598298,0.009759496722506984,0.9615820882674049,0.017013635024236834,0.9764105978252935,0.010367515457156272,7198]
["P30622-2","Isoform 3 of CAP-Gly domain-containing linker protein 1 [OS=Homo sapiens]",28,35,54,1,1392,156.7,5.36,147.85,"","","","CLIP1","","","","",322.7,341,301.8,371.3,389,479.7,0.7786290322580645,-0.3609919563235873,0.06117523145057935,1.2134243788618406,0.2661486706382646,0.5748756987037305,1680]
["P31146","Coronin-1A [OS=Homo sapiens]",62,30,362,27,461,51,6.68,1038.25,"cell adhesion;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","CORO1A","ENSG00000102879","Phagosome; Tuberculosis","Prevention of phagosomal-lysosomal fusion","16p11.2 proximal deletion syndrome",42363.6,41432,42570.3,40321.8,39726.6,42214.9,1.0335554495911694,0.04761579050914764,0.1738973496202758,0.7597070370545658,0.43143778967230006,0.36508181767720493,2946]
["P31153","S-adenosylmethionine synthase isoform type-2 [OS=Homo sapiens]",59,18,128,14,395,43.6,6.48,410.75,"cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;other cell component","other molecular function","MAT2A","ENSG00000168906","Cysteine and methionine metabolism; Metabolic pathways; Biosynthesis of amino acids; Biosynthesis of cofactors","Methylation","Trans-sulfuration and one-carbon metabolism; Methionine de novo and salvage pathway; One-carbon metabolism and related pathways; Methylation pathways",13197.1,13556,13250,14292,13405.7,13677.3,0.9668422960725076,-0.0486475073865561,0.1838995402627647,0.7354193564693395,0.4414192905683242,0.35514869155426076,3045]
["P31641","Sodium- and chloride-dependent taurine transporter [OS=Homo sapiens]",1,1,1,1,620,69.8,7.39,0,"transport;other biological processes","plasma membrane;other membranes;other cell component","transporter activity","SLC6A6","ENSG00000131389","","Na+/Cl- dependent neurotransmitter transporters; Amino acid transport across the plasma membrane","Nuclear receptors meta-pathway; NRF2 pathway",82.1,77.2,62.1,74.7,69.1,114.8,0.8561484918793503,-0.22406705302870222,0.471158585288088,0.32683289091051343,0.6482865398852853,0.1882329953865015,5312]
["P31943","Heterogeneous nuclear ribonucleoprotein H [OS=Homo sapiens]",56,20,433,8,449,49.2,6.3,1435.7,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","HNRNPH1","ENSG00000169045; ENSG00000284254","","mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA","MECP2 and associated Rett syndrome; mRNA processing; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells",31299.7,30581,28662.2,32126.9,33206.3,36018.8,0.8933508958875995,-0.16270113754457813,0.06197425753121037,1.2077886674972904,0.26818818726797905,0.571560355184326,1689]
["P31947-1","14-3-3 protein sigma [OS=Homo sapiens]",62,15,140,11,248,27.8,4.74,392.51,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;nucleus","enzyme regulator activity;other molecular function","SFN","ENSG00000175793; ENSGGOG00000011493; ENSNLEG00000018582; ENSPPAG00000013397; ENSPTRG00000030723","Cell cycle; p53 signaling pathway; Aldosterone-regulated sodium reabsorption","TP53 Regulates Metabolic Genes; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; Activation of BAD and translocation to mitochondria ; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest","miRNA regulation of DNA damage response; Cell cycle; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells; DNA damage response; Calcium regulation in cardiac cells",2037.6,2035.3,2098.9,2237,2133,2660.6,0.8778482633061189,-0.1879565044365786,0.15329062800183263,0.8144843965579514,0.4093537450001442,0.38790123208410204,2737]
["P32246","C-C chemokine receptor type 1 [OS=Homo sapiens]",3,1,1,1,355,41.1,8.16,1.86,"cell adhesion;cell-cell signaling;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;other cell component","other molecular function","CCR1","ENSG00000163823","Cytokine-cytokine receptor interaction; Viral protein interaction with cytokine and cytokine receptor; Chemokine signaling pathway; Human cytomegalovirus infection; Kaposi sarcoma-associated herpesvirus infection","G alpha (i) signalling events; Chemokine receptors bind chemokines; Interleukin-10 signaling","Peptide GPCRs; Chemokine signaling pathway; Selective expression of chemokine receptors during T-cell polarization; GPCRs, class A rhodopsin-like; CCL18 signaling pathway",131.3,122.5,122.9,258.2,272.4,240.4,0.48858625162127123,-1.0333148268550036,1.7112212195781129E-4,3.7666938430411654,0.02274057435253896,1.6431985706514365,55]
["P32455","Guanylate-binding protein 1 [OS=Homo sapiens]",35,18,53,16,592,67.9,6.32,161.45,"stress response;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","GBP1","ENSG00000117228","NOD-like receptor signaling pathway","Interferon gamma signaling","Type II interferon signaling (IFNG)",5928,5987.1,5634.5,5838.2,5614.4,7399.3,0.93091942987179,-0.10327178548612134,0.49008291369972273,0.30973043851018073,0.6614988026281207,0.17947093758754692,5415]
["P33121","Long-chain-fatty-acid--CoA ligase 1 [OS=Homo sapiens]",8,7,12,6,698,77.9,7.15,31.55,"other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle","other molecular function","ACSL1","ENSG00000151726","Fatty acid biosynthesis; Fatty acid degradation; Metabolic pathways; Fatty acid metabolism; PPAR signaling pathway; Peroxisome; Ferroptosis; Thermogenesis; Adipocytokine signaling pathway","PPARA activates gene expression; Synthesis of very long-chain fatty acyl-CoAs; alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism","Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters",976.2,1038.4,953.5,954.5,881.7,1926.4,0.7888428214532505,-0.34219022595369464,0.4767591202643091,0.3217009902744529,0.6514549280261424,0.186115626285497,5349]
["P33981","Dual specificity protein kinase TTK [OS=Homo sapiens]",6,5,6,5,857,97,8.16,15.62,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","TTK","ENSG00000112742","Cell cycle","","Cell cycle; Retinoblastoma gene in cancer",582.9,554.7,588.8,596.3,551.9,437.3,1.0888678650268055,0.12282889249681554,0.3878813656135675,0.4113010840390087,0.6012778157517635,0.22092481922838295,4715]
["P33993-1","DNA replication licensing factor MCM7 [OS=Homo sapiens]",68,42,230,42,719,81.3,6.46,689.22,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","MCM7","ENSG00000166508","DNA replication; Cell cycle","Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Assembly of the pre-replicative complex; Unwinding of DNA","miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication",23894.7,24920.7,25401.1,24061.8,23234.6,20324.3,1.0975411375510753,0.1342750152309491,0.14521648989346178,0.837984065019424,0.3982691649648451,0.3998233164980421,2665]
["P34932","Heat shock 70 kDa protein 4 [OS=Homo sapiens]",77,56,447,51,840,94.3,5.19,1386.98,"cell organization and biogenesis;stress response;transport","non-structural extracellular;cytosol;mitochondrion;nucleus","other molecular function","HSPA4","ENSG00000170606","Tight junction; Antigen processing and presentation; Lipid and atherosclerosis","Regulation of HSF1-mediated heat shock response","Parkin-ubiquitin proteasomal system pathway",53569.3,53519.4,55324.1,50395.3,50025.7,42113.3,1.139464676221794,0.18835620127758843,0.07468530938328666,1.126764815603774,0.2987821161918129,0.5246454010723389,1827]
["P35236","Tyrosine-protein phosphatase non-receptor type 7 [OS=Homo sapiens]",31,8,27,8,360,40.5,6.79,80.38,"protein metabolism;other metabolic processes;signal transduction","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","PTPN7","ENSG00000143851","MAPK signaling pathway","Interleukin-37 signaling; Negative regulation of MAPK pathway","MAPK signaling pathway; IL-18 signaling pathway",2943.2,3014.8,2983.7,3030.4,2828.2,2957.7,1.0142236539137737,0.020375826713159517,0.5412284209394373,0.26661940584181354,0.6955932000433177,0.1576446722100081,5687]
["P35241-1","radixin [OS=Homo sapiens]",55,38,230,19,583,68.5,6.37,622.21,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","RDX","ENSG00000137710; ENSPPAG00000040677; ENSRBIG00000033138; ENSRROG00000036137","Tight junction; Regulation of actin cytoskeleton; Proteoglycans in cancer; MicroRNAs in cancer","Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea","Regulation of actin cytoskeleton",8688.2,9313.4,8882.1,9634.7,9424,10184.9,0.9193020011216128,-0.12138921384400081,0.05472312563709824,1.261829104851964,0.2542729340632874,0.5946998655912781,1573]
["P35556","Fibrillin-2 [OS=Homo sapiens]",0,1,1,1,2912,314.6,4.86,0,"developmental processes;other biological processes","non-structural extracellular;extracellular matrix","extracellular structural activity;other molecular function","FBN2","ENSG00000138829","","Degradation of the extracellular matrix; Molecules associated with elastic fibres","Hypothesized pathways in pathogenesis of cardiovascular disease",28.2,52.4,24.5,142.3,61.3,142.3,0.3038450419196299,-1.71859234441075,0.04743745956261507,1.3238785769684154,0.23731717449907838,0.6246708310187392,1461]
["P35568","Insulin receptor substrate 1 [OS=Homo sapiens]",3,3,5,3,1242,131.5,8.54,11.72,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","IRS1","ENSG00000169047","cGMP-PKG signaling pathway; FoxO signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Neurotrophin signaling pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Regulation of lipolysis in adipocytes; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; Growth hormone synthesis, secretion and action; Aldosterone-regulated sodium reabsorption; Alzheimer disease; MicroRNAs in cancer; Diabetic cardiomyopathy","RAF/MAP kinase cascade; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by ALK fusions and activated point mutants; PI3K Cascade; Interleukin-7 signaling; PI3K/AKT activation; Signaling by ALK; Growth hormone receptor signaling; Signaling by Leptin; SOS-mediated signalling; IRS activation; Signal attenuation; Activated NTRK3 signals through PI3K","Type II diabetes mellitus; Integrated breast cancer pathway; Leptin signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; AGE/RAGE pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Transcription factor regulation in adipogenesis; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; PI3K-Akt signaling pathway; Nonalcoholic fatty liver disease; Gastrin signaling pathway; Insulin signaling; FOXA2 pathway; Neuroinflammation and glutamatergic signaling; Congenital generalized lipodystrophy (CGL); Alzheimer's disease; EPO receptor signaling; Interferon type I signaling pathways; DNA damage response (only ATM dependent)",363.6,345.7,359.4,538.4,529.7,623.2,0.631880801750133,-0.6622756613946079,2.3806172757558945E-3,2.6233104191215877,0.06192146501245492,1.2081587771426947,281]
["P35612-1","Beta-adducin [OS=Homo sapiens]",17,9,14,9,726,80.8,5.92,31.34,"cell adhesion;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ADD2","ENSG00000075340","","Miscellaneous transport and binding events","",865.2,996.6,906,951.9,917.1,1201.3,0.9014754258541511,-0.1496399304416909,0.3597328244802144,0.4440199323782515,0.5876815409311325,0.23085795025488945,4474]
["P35813","Protein phosphatase 1A [OS=Homo sapiens]",39,13,32,12,382,42.4,5.36,89.7,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus","other molecular function","PPM1A","ENSG00000100614","MAPK signaling pathway","Energy dependent regulation of mTOR by LKB1-AMPK; Downregulation of SMAD2/3:SMAD4 transcriptional activity","TGF-beta signaling pathway; MAPK signaling pathway",3341.7,3501,3325.9,3348.5,3301.5,4933.9,0.8778218044009358,-0.1879999888383463,0.43113850726858094,0.3653831862683489,0.6236278150853074,0.20507452262260645,5053]
["P35998","26S proteasome regulatory subunit 7 [OS=Homo sapiens]",67,25,125,25,433,48.6,5.95,394.41,"protein metabolism;other metabolic processes;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","PSMC2","ENSG00000161057","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection","Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of expression of SLITs and ROBOs; Downstream TCR signaling; Interleukin-1 signaling; Neutrophil degranulation; AUF1 (hnRNP D0) binds and destabilizes mRNA; MAPK6/MAPK4 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Orc1 removal from chromatin; SCF(Skp2)-mediated degradation of p27/p21; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease",11988.3,12262.2,12487.1,12173,11663.1,9645.7,1.0972408890800376,0.13388029085500033,0.23898355967717957,0.6216319743115438,0.4987809359453186,0.3020901541749982,3502]
["P36551","Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial [OS=Homo sapiens]",43,18,69,18,454,50.1,8.25,212.4,"other metabolic processes","cytosol;mitochondrion;other cell component","other molecular function","CPOX","ENSG00000080819","Porphyrin and chlorophyll metabolism; Metabolic pathways; Biosynthesis of cofactors","Heme biosynthesis","Heme biosynthesis",7347.6,7487,7244.9,7153.6,6752.8,8091.3,1.003718570577833,0.005354813365101173,0.9492756334577201,0.022607666699165897,0.9672738888808694,0.014450535650630175,7173]
["P36969","Phospholipid hydroperoxide glutathione peroxidase, mitochondrial [OS=Homo sapiens]",38,8,39,8,197,22.2,8.37,102.9,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","GPX4","ENSG00000167468","Glutathione metabolism; Metabolic pathways; Ferroptosis","Synthesis of 15-eicosatetraenoic acid derivatives; Synthesis of 12-eicosatetraenoic acid derivatives; Synthesis of 5-eicosatetraenoic acids","Glutathione metabolism; Selenium micronutrient network; Folate metabolism; One-carbon metabolism and related pathways; Ferroptosis; Metapathway biotransformation Phase I and II",3432.3,3551.4,3940,3059.1,2700.2,3102.3,1.2327006409677712,0.3018224864981888,0.026100385360047332,1.583353080458401,0.1834304967274865,0.7365284578732083,1040]
["P37235","Hippocalcin-like protein 1 [OS=Homo sapiens]",52,10,18,10,193,22.3,5.35,42.62,"","other membranes","other molecular function","HPCAL1","ENSG00000115756","","","",1822.4,2097.8,2395.4,2692.4,2662.7,3285.2,0.7309468421235374,-0.45216160443241177,0.04150113459542308,1.3819400299916236,0.2233665631501821,0.6509818380521335,1358]
["P38432","coilin [OS=Homo sapiens]",16,10,16,10,576,62.6,9.07,42.12,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","COIL","ENSG00000121058","","","Genotoxicity pathway",1515.3,1487.9,1452,1873.8,2051.8,2588.2,0.6839632779637077,-0.5480092260946685,0.033393884366267966,1.4763330610079592,0.20272084786798386,0.6931015860457921,1204]
["P38606","V-type proton ATPase catalytic subunit A [OS=Homo sapiens]",66,30,212,30,617,68.3,5.52,604.83,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ATP6V1A","ENSG00000114573","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis","Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Proximal tubule transport",20544.4,20879.8,20042.9,19573.5,18777,16701.5,1.1165280098815664,0.15901944391484815,0.07412253796261142,1.130049718814998,0.29783487079094384,0.5260244559945086,1819]
["P39210","Protein Mpv17 [OS=Homo sapiens]",16,2,3,2,176,19.7,9.47,5.65,"cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component","transporter activity","MPV17","ENSG00000115204","Peroxisome","Peroxisomal protein import","",326.9,330.4,339.7,280,369.3,340.7,1.007070707070707,0.01016497943122386,0.9343246184898681,0.029502207789999346,0.9576467026423288,0.018794682353869083,7131]
["P40306","Proteasome subunit beta type-10 [OS=Homo sapiens]",27,6,23,6,273,28.9,7.81,77.74,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","PSMB10","ENSG00000205220","Proteasome","Regulation of PTEN stability and activity; FCERI mediated NF-kB activation; Downstream TCR signaling; Regulation of expression of SLITs and ROBOs; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; MAPK6/MAPK4 signaling; Degradation of beta-catenin by the destruction complex; ER-Phagosome pathway; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; CDT1 association with the CDC6:ORC:origin complex; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation",2872.7,2639.6,2880,2768.7,2808.6,3426.3,0.9321049358034564,-0.10143571313954367,0.42017354504223836,0.37657129510917137,0.6180415457262467,0.20898232997073127,4969]
["P40616","ADP-ribosylation factor-like protein 1 [OS=Homo sapiens]",64,9,33,9,181,20.4,5.72,97.08,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","ARL1","ENSG00000120805","","Retrograde transport at the Trans-Golgi-Network","",2291.4,2441,2776.6,2187.3,2186.1,1673.5,1.2417933155831915,0.3124250709846608,0.09442781079662729,1.024900078829836,0.3294381236814076,0.48222614424817695,2095]
["P40937-1","Replication factor C subunit 5 [OS=Homo sapiens]",45,13,39,13,340,38.5,7.2,117.6,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RFC5","ENSG00000111445","DNA replication; Nucleotide excision repair; Mismatch repair","Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER","Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair",4178.8,4733.6,4583.9,4415,3909.8,4728.2,1.0339615414081056,0.048182525061293016,0.6375880923342161,0.1954598024680186,0.7660909694017402,0.11571965704696896,6083]
["P41226","ubiquitin-like modifier-activating enzyme 7 [OS=Homo sapiens]",8,7,9,7,1012,111.6,6.04,25.58,"protein metabolism;other metabolic processes;stress response","cytosol;nucleus;other cell component","other molecular function","UBA7","ENSG00000182179","Ubiquitin mediated proteolysis; Parkinson disease; Pathways of neurodegeneration","Termination of translesion DNA synthesis; Antigen processing: Ubiquitination & Proteasome degradation; ISG15 antiviral mechanism; Negative regulators of DDX58/IFIH1 signaling","Proteasome degradation; Parkinson's disease pathway",1050,1039.7,1010.5,1052.4,967.9,1962.7,0.7783580215917648,-0.3614941901055322,0.40805131788935517,0.3892852151584957,0.6119095368184851,0.21331277812322827,4874]
["P41227-1","N-alpha-acetyltransferase 10 [OS=Homo sapiens]",47,12,58,12,235,26.4,5.64,151.74,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","translation activity;other molecular function","NAA10","ENSCATG00000038709; ENSCSAG00000006823; ENSG00000102030; ENSGGOG00000009788; ENSMFAG00000044161; ENSMMUG00000000322; ENSMNEG00000034261; ENSPPYG00000020861; ENSPTRG00000022419; ENSRROG00000041881","","","",5060.8,4959.4,4951.8,5753.6,5395,7997,{"$f":"AVERAGE(S1794:U1794)/AVERAGE(V1794:X1794)","v":0.7820073541701489},{"$f":"LOG(Y1794,2)","v":-0.3547459198676313},{"$f":"TTEST(V1794:X1794,S1794:U1794,2,2)","v":0.16298660101614823},0.7878480970925765,{"$f":"AA1794*7309/AE1794","v":0.4199045001152723},0.3768494710044558,2837]
["P41567","eukaryotic translation initiation factor 1 [OS=Homo sapiens]",39,4,6,4,113,12.7,7.44,21.11,"protein metabolism;other metabolic processes;other biological processes","translational apparatus;nucleus;other cell component","translation activity;nucleic acid binding activity","EIF1","ENSG00000173812","","","Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell",265.8,250.3,264.2,293.4,302.3,274.4,0.8967934720147107,-0.1571523184459421,0.035456396747176024,1.4503054016265473,0.20848817685045018,0.680918568384219,1243]
["P42167-2","Isoform Gamma of Lamina-associated polypeptide 2, isoforms beta/gamma [OS=Homo sapiens]",54,18,162,2,345,38.7,9.16,512.19,"","","","TMPO","","","","",533.2,488.8,496.5,585.6,606.7,486.7,0.9044073853484216,-0.14495532176957052,0.24648706711789045,0.6082058627018949,0.5052086297152724,0.2965292396572578,3566]
["P42285","Superkiller viralicidic activity 2-like 2 [OS=Homo sapiens]",29,28,77,28,1042,117.7,6.52,226.12,"RNA metabolism OR transcription;other metabolic processes;stress response","nucleus","other molecular function","MTREX","ENSG00000039123","RNA degradation","Major pathway of rRNA processing in the nucleolus and cytosol; mRNA Splicing - Major Pathway","",7190,7288,7618.5,9534.3,9726.6,7600.9,0.8225993790438466,-0.28173811209684413,0.08307071271096134,1.080552063459045,0.3131324596206376,0.5042719106537775,1939]
["P42574","Caspase-3 [OS=Homo sapiens]",50,10,57,9,277,31.6,6.54,162.65,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","CASP3","ENSG00000164305","Platinum drug resistance; MAPK signaling pathway; p53 signaling pathway; Apoptosis; Apoptosis; Natural killer cell mediated cytotoxicity; IL-17 signaling pathway; TNF signaling pathway; Serotonergic synapse; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Alcoholic liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Salmonella infection; Pertussis; Legionellosis; Toxoplasmosis; Amoebiasis; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Colorectal cancer; Small cell lung cancer; Viral myocarditis; Lipid and atherosclerosis","Caspase-mediated cleavage of cytoskeletal proteins; Degradation of the extracellular matrix; Other interleukin signaling; Apoptosis induced DNA fragmentation; Signaling by Hippo; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Caspase activation via Dependence Receptors in the absence of ligand; Pyroptosis; NADE modulates death signalling; Apoptotic cleavage of cell adhesion  proteins; Stimulation of the cell death response by PAK-2p34","miRNA regulation of DNA damage response; Integrated breast cancer pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; AGE/RAGE pathway; Allograft Rejection; Corticotropin-releasing hormone signaling pathway; Parkinson's disease pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Copper homeostasis; Hepatitis C and hepatocellular carcinoma; MAPK signaling pathway; Apoptosis modulation by HSP70; ERK pathway in Huntington's disease; Oxidative damage response; miRNA regulation of p53 pathway in prostate cancer; Prion disease pathway; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; MTHFR deficiency; Acute viral myocarditis; Nonalcoholic fatty liver disease; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; Peroxiredoxin 2 induced ovarian failure; Complement system in neuronal development and plasticity; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; Sudden infant death syndrome (SIDS) susceptibility pathways; DNA damage response",6970.5,6860.1,6559,7027.1,6930.9,6633.7,0.990185365948416,-0.01422946716844329,0.7132489011680054,0.14675888874489848,0.8141708915566065,0.08928442868509312,6403]
["P42680","Tyrosine-protein kinase Tec [OS=Homo sapiens]",8,5,9,5,631,73.5,8.44,26.54,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton","kinase activity;other molecular function","TEC","ENSG00000135605","Osteoclast differentiation; T cell receptor signaling pathway","FCERI mediated Ca+2 mobilization; Interleukin-3, Interleukin-5 and GM-CSF signaling; Signaling by SCF-KIT","Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; Kit receptor signaling pathway",999.6,1001.8,1030.2,893.9,946.5,1255.9,0.9791040919807512,-0.03046584894865194,0.8583721898155995,0.06632436141171938,0.9097799210212031,0.04106365234440281,6896]
["P42766","60S ribosomal protein L35 [OS=Homo sapiens]",28,4,12,4,123,14.5,11.05,22.64,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;translational apparatus;nucleus","nucleic acid binding activity;other molecular function","RPL35","ENSG00000136942","Ribosome; Coronavirus disease","Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",2469.5,2338.9,2529.1,2417.4,2643.8,2010.2,1.0376304550725457,0.05329272928333247,0.6707667380840932,0.1734284812846313,0.7878248575697633,0.10357032038512885,6223]
["P43243","Matrin-3 [OS=Homo sapiens]",46,44,247,44,847,94.6,6.25,724.57,"stress response;developmental processes;other biological processes","other membranes;nucleus","nucleic acid binding activity;other molecular function","MATR3","ENSG00000015479","Amyotrophic lateral sclerosis","","",31037.8,30007.6,30681.8,34868.3,35524.9,29746.6,0.9159914439613418,-0.1265939723426448,0.20442226292168564,0.6894718084515635,0.46329374254096134,0.33414356553887714,3225]
["P43246-1","DNA mismatch repair protein MSH2 [OS=Homo sapiens]",46,34,131,34,934,104.7,5.77,390.5,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MSH2","ENSG00000095002","Platinum drug resistance; Mismatch repair; Pathways in cancer; Colorectal cancer","TP53 Regulates Transcription of DNA Repair Genes; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MSH3; Defective Mismatch Repair Associated With MSH2; Defective Mismatch Repair Associated With MSH6","RAC1/PAK1/p38/MMP2 pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ciliary landscape; DNA repair pathways, full network; p53 transcriptional gene network; DNA mismatch repair",14956.2,15503.1,15103.8,15945.3,15454.3,16052.4,0.9601934586529547,-0.05860298726107837,0.06277461878868075,1.2022159159463834,0.27005278912682024,0.568551332931456,1699]
["P43490","nicotinamide phosphoribosyltransferase [OS=Homo sapiens]",64,26,133,26,491,55.5,7.15,417.93,"cell-cell signaling;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","NAMPT","ENSG00000105835","Nicotinate and nicotinamide metabolism; Metabolic pathways; NOD-like receptor signaling pathway","BMAL1:CLOCK,NPAS2 activates circadian gene expression; Nicotinamide salvaging","Adipogenesis; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; Caloric restriction and aging; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence",15534,16658.2,15442.8,15764.1,14495.6,14702.5,1.0594454897669598,0.08330936055956667,0.1831937501038533,0.7370893469438744,0.44131941974590105,0.35524696151061314,3034]
["P45880","Voltage-dependent anion-selective channel protein 2 [OS=Homo sapiens]",65,14,219,13,294,31.5,7.56,684.41,"cell organization and biogenesis;transport;signal transduction;other biological processes","other membranes;mitochondrion;ER/Golgi;other cell component","transporter activity;other molecular function","VDAC2","ENSG00000165637","Calcium signaling pathway; cGMP-PKG signaling pathway; Ferroptosis; Necroptosis; Cellular senescence; Neutrophil extracellular trap formation; NOD-like receptor signaling pathway; Cholesterol metabolism; Alzheimer disease; Parkinson disease; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Human T-cell leukemia virus 1 infection; Chemical carcinogenesis; Diabetic cardiomyopathy","Ub-specific processing proteases; Mitochondrial calcium ion transport","Alzheimer's disease and miRNA effects; Ferroptosis; Alzheimer's disease",19575.9,19082.8,20004.9,16009.5,15971.1,11325.8,1.3546173313875087,0.43788535926883404,0.031524746504788405,1.5013483969678614,0.19778057699871113,0.7038163604459262,1165]
["P46013","Proliferation marker protein Ki-67 [OS=Homo sapiens]",54,140,476,13,3256,358.5,9.45,1457.52,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MKI67","ENSG00000148773","","","Primary focal segmental glomerulosclerosis (FSGS)",50700.1,54722.9,51729.5,58365.7,60126.3,61058.2,0.875256613470773,-0.19222203713625025,0.006615409177411557,2.179443288589682,0.09847663070814883,1.0066668188286771,491]
["P46108-1","Adapter molecule crk [OS=Homo sapiens]",21,4,6,4,304,33.8,5.55,20.67,"cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","Crk; CRK","ENSANAG00000030093; ENSBTAG00000005665; ENSCANG00000032179; ENSCATG00000041862; ENSCCAG00000032085; ENSG00000167193; ENSGGOG00000006758; ENSLAFG00000010559; ENSMFAG00000000502; ENSMMUG00000040390; ENSMNEG00000039514; ENSPPAG00000029995; ENSPTRG00000045379; ENSRBIG00000006454; ENSRROG00000035466","MAPK signaling pathway; ErbB signaling pathway; Rap1 signaling pathway; Chemokine signaling pathway; Focal adhesion; Fc gamma R-mediated phagocytosis; Neurotrophin signaling pathway; Regulation of actin cytoskeleton; Insulin signaling pathway; Growth hormone synthesis, secretion and action; Bacterial invasion of epithelial cells; Shigellosis; Yersinia infection; Human cytomegalovirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; MicroRNAs in cancer; Renal cell carcinoma; Chronic myeloid leukemia","Regulation of signaling by CBL; ARMS-mediated activation; FCGR3A-mediated phagocytosis; Regulation of signaling by CBL; Regulation of actin dynamics for phagocytic cup formation; Downstream signal transduction; VEGFA-VEGFR2 Pathway; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; ARMS-mediated activation; p130Cas linkage to MAPK signaling for integrins; MET activates RAP1 and RAC1; MET receptor recycling","Kit receptor signaling pathway; TCR signaling pathway; B cell receptor signaling pathway; ErbB signaling pathway; Hepatocyte growth factor receptor signaling; Actin cytoskeleton regulation; Integrin-mediated cell adhesion; Integrin-mediated cell adhesion; B cell receptor signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; Focal adhesion; Interferon type I signaling pathways; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Rett syndrome causing genes; EGF/EGFR signaling pathway; Gastrin signaling pathway; Insulin signaling; Regulation of actin cytoskeleton; Interferon type I signaling pathways; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; EGFR1 signaling pathway; MAPK signaling pathway; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; Integrin-mediated cell adhesion; Insulin signaling; EGF/EGFR signaling pathway; MAPK signaling pathway",488.6,482.6,545.4,492.2,510.6,363.9,1.1096802517011781,0.15014403176538646,0.3766838427012011,0.4240230078195653,0.5945113811926319,0.22583982692948576,4631]
["P46736","Lys-63-specific deubiquitinase BRCC36 [OS=Homo sapiens]",27,8,28,1,316,36,5.92,93.21,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","BRCC3","ENSG00000185515","Homologous recombination; NOD-like receptor signaling pathway","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs","",2083.6,2040.9,1803.6,1942.2,1926.3,1714.7,1.0617746095429146,0.08647754749300607,0.3697156354907309,0.4321321824705527,0.5918203197112905,0.22781012774079612,4566]
["P46777","60S ribosomal protein L5 [OS=Homo sapiens]",64,20,365,20,297,34.3,9.72,1037.11,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;ER/Golgi;translational apparatus;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","RPL5","ENSG00000122406","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; SRP-dependent cotranslational protein targeting to membrane; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","VEGFA-VEGFR2 signaling pathway; Cytoplasmic ribosomal proteins",45915.7,45641.9,44779.1,46480.4,47979.2,46094.6,0.9699937817582115,-0.043952596098263096,0.10352236131787343,0.9849658304193221,0.3434611615398715,0.4641223656861167,2203]
["P46940","Ras GTPase-activating-like protein IQGAP1 [OS=Homo sapiens]",63,84,618,82,1657,189.1,6.48,2180.23,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","IQGAP1","ENSG00000140575","Adherens junction; Regulation of actin cytoskeleton; Proteoglycans in cancer","Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; RHOV GTPase cycle; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHO GTPases activate IQGAPs; RAC2 GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants","VEGFA-VEGFR2 signaling pathway; Ebola virus pathway in host; Ciliary landscape; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway",64432.5,65046.4,63639.3,56989,56244.8,43318.6,1.2335690797458232,0.302838508679114,0.05217652328470559,1.2825248629240333,0.24925373116857066,0.6033583318576593,1530]
["P46976-2","Isoform GN-1 of Glycogenin-1 [OS=Homo sapiens]",39,10,56,10,333,37.5,5.4,196.35,"","","","GYG1","","","","",5473.4,5568.2,5494.1,4948.4,5270.3,4639,1.112938072514588,0.15437331868013748,0.03872561135363664,1.4120017173927688,0.21639563714352464,0.6647514994970444,1308]
["P47985","cytochrome b-c1 complex subunit Rieske, mitochondrial [OS=Homo sapiens]",37,10,82,10,274,29.6,8.32,229.58,"cell organization and biogenesis;other metabolic processes;transport","other membranes;mitochondrion","transporter activity;other molecular function","UQCRFS1","ENSG00000169021","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly",7551.6,7979,8011.6,7146.1,6960.7,5919.7,1.1755523930791703,0.23333883975745984,0.04582544153662634,1.3388933418377247,0.2340588065626848,0.630675013713528,1431]
["P48163","NADP-dependent malic enzyme [OS=Homo sapiens]",31,13,54,13,572,64.1,6.13,156.68,"other metabolic processes;other biological processes","cytosol;mitochondrion","other molecular function","ME1","ENSG00000065833","Pyruvate metabolism; Metabolic pathways; Carbon metabolism; PPAR signaling pathway","PPARA activates gene expression; Pyruvate metabolism","Nuclear receptors meta-pathway; NRF2 pathway; PPAR signaling pathway; Clear cell renal cell carcinoma pathways; TCA cycle in senescence",5208.5,5345,5231.1,5523.8,5140.7,4519.9,1.0395274097099656,0.055927798919033496,0.535552056103771,0.2711983089967587,0.6903615481591644,0.1609234060056923,5670]
["P48431","Transcription factor SOX-2 [OS=Homo sapiens]",3,1,1,1,317,34.3,9.74,1.83,"cell organization and biogenesis;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SOX2","ENSG00000181449","Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells","Interleukin-4 and Interleukin-13 signaling; POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation; Transcriptional Regulation by MECP2; Deactivation of the beta-catenin transactivating complex; POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation","Cell differentiation - expanded index; Cardiac progenitor differentiation; Endoderm differentiation; Dopaminergic neurogenesis; Mesodermal commitment pathway; Ectoderm differentiation; let-7 inhibition of ES cell reprogramming; Pre-implantation embryo; Wnt signaling pathway and pluripotency; Sudden infant death syndrome (SIDS) susceptibility pathways",190.1,171.9,167.9,308.6,311.1,659.5,0.41424327704815506,-1.2714498114369965,0.09916718265558608,1.0036320249183805,0.33649625720969295,0.47301976199637036,2154]
["P48553","Trafficking protein particle complex subunit 10 [OS=Homo sapiens]",3,4,7,4,1259,142.1,6.04,17.74,"transport","cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","TRAPPC10","ENSG00000160218","","COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs","",611.6,613.4,602.9,785.4,660.6,932,0.7686711522287638,-0.37956156889455256,0.07973072022972884,1.0983743127863097,0.3067114916626779,0.5132699518551657,1900]
["P48723","Heat shock 70 kDa protein 13 [OS=Homo sapiens]",22,9,30,9,471,51.9,5.76,85.01,"stress response;other biological processes","mitochondrion;ER/Golgi;other cell component","other molecular function","HSPA13","ENSG00000155304","","Regulation of HSF1-mediated heat shock response","",3155.2,3083.5,2998.8,3625.2,3624.9,6151.5,0.6892833691499523,-0.5368308881225704,0.17514347186739435,0.7566060455275856,0.4326203568363587,0.3638930488042456,2959]
["P48729-3","Isoform 3 of Casein kinase I isoform alpha [OS=Homo sapiens]",24,8,14,1,325,37.5,9.48,22.4,"","","","CSNK1A1","","","","",71.1,64.8,63.5,71.2,71.7,78.4,0.9010393131495705,-0.15033804140281598,0.09146741055649969,1.038733615622967,0.3256382385569685,0.48726460310958586,2053]
["P49116-1","Nuclear receptor subfamily 2 group C member 2 [OS=Homo sapiens]",8,4,8,4,596,65.4,6.28,19.2,"developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NR2C2","ENSCANG00000032916; ENSG00000177463; ENSMLEG00000044042; ENSMMUG00000005156; ENSPPAG00000023138","","Nuclear Receptor transcription pathway","Androgen receptor signaling pathway; Nuclear receptors; Hypothesized pathways in pathogenesis of cardiovascular disease; Epithelial to mesenchymal transition in colorectal cancer; Androgen receptor signaling pathway; Nuclear receptors",768.2,760.8,764,819.6,786.9,727.9,0.9822652501713502,-0.02581543344973505,0.6351881348683954,0.19709762300115938,0.7650939482124427,0.11628523323187927,6068]
["P49137","MAP kinase-activated protein kinase 2 [OS=Homo sapiens]",17,7,14,5,400,45.5,8.68,31.3,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","MAPKAPK2","ENSG00000162889","MAPK signaling pathway; Cellular senescence; VEGF signaling pathway; C-type lectin receptor signaling pathway; Neurotrophin signaling pathway; Kaposi sarcoma-associated herpesvirus infection; Viral carcinogenesis","VEGFA-VEGFR2 Pathway; Oxidative Stress Induced Senescence; activated TAK1 mediates p38 MAPK activation; Regulation of HSF1-mediated heat shock response; p38MAPK events; CREB phosphorylation; Synthesis of Leukotrienes (LT) and Eoxins (EX); Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA","IL-1 signaling pathway; Microtubule cytoskeleton regulation; Interleukin-1 (IL-1) structural pathway; Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; VEGFA-VEGFR2 signaling pathway; p38 MAPK signaling pathway; Malignant pleural mesothelioma; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling",1358.6,1323.1,1432.7,1280.7,1331.5,1593.3,0.9783378908572107,-0.031595276668505,0.7809308868229061,0.10738739992500358,0.860259811874698,0.0653703652414849,6635]
["P49356","protein farnesyltransferase subunit beta [OS=Homo sapiens]",5,2,6,2,437,48.7,5.82,28.73,"protein metabolism;other metabolic processes","cytosol;cytoskeleton;other cell component","other molecular function","FNTB","ENSG00000257365","Terpenoid backbone biosynthesis","RAS processing; Potential therapeutics for SARS; Inactivation, recovery and regulation of the phototransduction cascade","",524.8,507.4,514.3,482.9,463.5,440.3,1.1152376144804208,0.15735112602953594,0.016113069929335547,1.7928217081001057,0.147397281744072,0.8315105255301241,799]
["P49406","39S ribosomal protein L19, mitochondrial [OS=Homo sapiens]",34,9,28,9,292,33.5,9.5,78.73,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus","other molecular function","MRPL19","ENSG00000115364","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","Cytoplasmic ribosomal proteins",3308.7,3422,3600,3326.3,3109,2288.6,1.1841836793177365,0.2438928754669752,0.17693527998317252,0.7521855623737265,0.43498821439522634,0.3615225096946913,2973]
["P49454","Centromere protein F [OS=Homo sapiens]",19,55,69,54,3210,367.5,5.07,183.38,"","","","","","","","",5367.1,5307.3,5342.3,5651.7,5906.9,7448.6,0.8426648848857277,-0.2469690877234374,0.15053740874033775,0.8223555639192439,0.40496058906261634,0.3925872404531617,2717]
["P49642","DNA primase small subunit [OS=Homo sapiens]",20,5,8,5,420,49.9,8.21,27.68,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","PRIM1","ENSG00000198056","DNA replication","Activation of the pre-replicative complex; Removal of the Flap Intermediate; Polymerase switching on the C-strand of the telomere; Polymerase switching; Defective pyroptosis; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Telomere C-strand synthesis initiation; DNA replication initiation","Retinoblastoma gene in cancer; Pyrimidine metabolism; G1 to S cell cycle control; DNA replication",439.3,454.3,459.9,471.3,484.7,421.6,0.9825058072009292,-0.025462160294517887,0.7105637211856224,0.14839696978660305,0.813647225152078,0.08956385233243536,6383]
["P49736","DNA replication licensing factor mcm2 [OS=Homo sapiens]",53,38,216,38,904,101.8,5.52,634.35,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MCM2","ENSG00000073111","DNA replication; Cell cycle","Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Assembly of the pre-replicative complex; Unwinding of DNA","Cell cycle; Ciliary landscape; G1 to S cell cycle control; DNA replication",19914.2,20460.7,20313.8,21544.8,21171.9,19868.8,0.9696926604405174,-0.04440053059507869,0.30167979327080946,0.5204537782071083,0.5520725110206175,0.2580038768578191,3994]
["P49750-4","Isoform 4 of YLP motif-containing protein 1 [OS=Homo sapiens]",19,36,59,35,2146,241.5,6.55,155.29,"other biological processes","cytosol;nucleus","","YLPM1","ENSG00000119596","","","",7021.4,7306.4,7085.6,7504.5,7360.1,8231.2,0.9271555867300547,-0.1091166358973281,0.11860479910545348,0.9258977377605508,0.36623678777429636,0.4362380338056606,2367]
["P49770","Translation initiation factor eIF-2B subunit beta [OS=Homo sapiens]",27,8,18,8,351,39,6.16,55.22,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity;other molecular function","EIF2B2","ENSG00000119718","Herpes simplex virus 1 infection","Recycling of eIF2:GDP","Translation factors; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Rett syndrome causing genes",1256,1289.6,1249.8,1291.8,1320.8,2237.3,0.782572836553331,-0.3537030603577291,0.3211417089511768,{"$f":"-LOG10(AA1987)","v":0.4933032858660842},0.5662785888357421,{"$f":"-LOG10(AC1987)","v":0.24696985886840356},4145]
["P49773","Histidine triad nucleotide-binding protein 1 [OS=Homo sapiens]",48,4,23,4,126,13.8,6.95,82.96,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","HINT1","ENSG00000169567","","","",3315.9,2994.4,3690.3,3644.3,3872.2,3459.9,0.9111001785649212,-0.1343184029095427,0.2365088988940709,0.6261525138357609,0.4961663438624467,0.3043726982874135,3484]
["P49840","Glycogen synthase kinase-3 alpha [OS=Homo sapiens]",35,10,22,7,483,50.9,8.75,54.73,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function","GSK3A","ENSG00000105723","Chemokine signaling pathway; Dopaminergic synapse; Non-alcoholic fatty liver disease; Shigellosis","XBP1(S) activates chaperone genes; Constitutive Signaling by AKT1 E17K in Cancer; AKT phosphorylates targets in the cytosol; Suppression of apoptosis; Maturation of nucleoprotein; Maturation of nucleoprotein","IL-5 signaling pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; Wnt signaling pathway; Regulation of apoptosis by parathyroid hormone-related protein; Angiopoietin-like protein 8 regulatory pathway; Nonalcoholic fatty liver disease; Insulin signaling; Glycogen synthesis and degradation",1499.9,1696.3,1726.6,1435.5,1391.3,1338.7,1.1818029048133476,0.24098945010246833,0.029778809890267714,1.5260926628100873,0.1926135588389086,0.7153131444095341,1130]
["P49916-1","DNA ligase 3 [OS=Homo sapiens]",32,28,62,28,1009,112.8,9.01,209.66,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","LIG3","ENSG00000005156","Base excision repair","HDR through MMEJ (alt-NHEJ); Gap-filling DNA repair synthesis and ligation in TC-NER; Gap-filling DNA repair synthesis and ligation in GG-NER; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; Resolution of AP sites via the single-nucleotide replacement pathway","Base excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum",7255.5,7438.3,7300.9,7530.7,7751.9,9904.9,0.8732387096774191,-0.19555201011313827,0.23360680584564855,0.6315145087422002,0.494048652756321,0.3062302806650829,3456]
["P50336","protoporphyrinogen oxidase [OS=Homo sapiens]",31,11,24,11,477,50.7,8.16,62.92,"other metabolic processes;other biological processes","other membranes;mitochondrion","other molecular function","PPOX","ENSG00000143224","Porphyrin and chlorophyll metabolism; Metabolic pathways; Biosynthesis of cofactors","Heme biosynthesis","Orexin receptor pathway; Heme biosynthesis",1787.6,1774.6,1777.8,1556,1514.5,2134.4,1.0259563103998157,0.03696929613837355,0.8329784393517121,0.07936623963974342,0.8950660707470838,0.04814490535247379,6802]
["P50443","sulfate transporter [OS=Homo sapiens]",1,1,1,1,739,81.6,8.38,2.85,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes","transporter activity","SLC26A2","ENSG00000155850","Chemical carcinogenesis","Transport and synthesis of PAPS; Multifunctional anion exchangers; Defective SLC26A2 causes chondrodysplasias","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Proteoglycan biosynthesis",39.6,42.3,33.9,45.2,45.3,71.4,0.7152563310685608,-0.4834677323133294,0.16516289243296212,0.7820875201017962,0.42194183180444605,0.3747474160230858,2861]
["P50570-1","Dynamin-2 [OS=Homo sapiens]",44,37,151,2,870,98,7.44,464.51,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","DNM2","ENSG00000079805; ENSGGOG00000005968; ENSPTRG00000034439","Phospholipase D signaling pathway; Endocytosis; Fc gamma R-mediated phagocytosis; Synaptic vesicle cycle; Endocrine and other factor-regulated calcium reabsorption; Bacterial invasion of epithelial cells; Salmonella infection","MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Recycling pathway of L1; Clathrin-mediated endocytosis; NGF-stimulated transcription; Toll Like Receptor 4 (TLR4) Cascade; NOSTRIN mediated eNOS trafficking; Retrograde neurotrophin signalling; Formation of annular gap junctions","Synaptic vesicle pathway; Fragile X syndrome; Intracellular trafficking proteins involved in CMT neuropathy",18797.5,19084,19612.9,16611.5,16131.8,18262,1.127224033580824,0.17277427683668947,0.03470653313167667,1.4595887662473375,0.20556730199305087,0.6870459640605874,1234]
["P50579-2","Isoform 2 of Methionine aminopeptidase 2 [OS=Homo sapiens]",35,13,57,1,455,50.5,5.35,180.07,"","","","METAP2","","","","",67,65.3,74.8,83.8,88.2,93.6,0.7797439759036144,-0.358927593126413,8.72322322246963E-3,2.0593230140257863,0.11225006783984247,0.9498133878528322,568]
["P50897","Palmitoyl-protein thioesterase 1 [OS=Homo sapiens]",20,5,15,5,306,34.2,6.52,51.73,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PPT1","ENSG00000131238","Fatty acid elongation; Metabolic pathways; Fatty acid metabolism; Lysosome","Fatty acyl-CoA biosynthesis","",1358.2,1503.2,1364.9,1611.1,1493.8,1505.9,0.9166088314392298,-0.12562190887816865,0.10020267201331282,0.9991206973793022,0.3382823693973687,0.47072063618471355,2165]
["P50914","60S ribosomal protein L14 [OS=Homo sapiens]",29,6,40,6,215,23.4,10.93,109.32,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","other molecular function","RPL14","ENSG00000188846","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",4799.1,4419.9,4989.5,5218,5207.7,6522.8,0.8383337758503703,-0.2544033391591814,0.12253240266542048,0.9117490505812741,0.37053758009166665,0.43116773910495154,2417]
["P51151","Ras-related protein Rab-9A [OS=Homo sapiens]",47,7,8,7,201,22.8,5.47,21.06,"transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","RAB9A","ENSG00000123595","Salmonella infection; Measles","RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Retrograde transport at the Trans-Golgi-Network; RHOBTB3 ATPase cycle","Ebola virus pathway in host",874,822.1,777.9,673.1,749.6,1054.9,0.9985469809493056,-2.0977878109312313E-3,0.9924931161134933,3.2724968009096426E-3,0.9961730548851309,1.6652095148616461E-3,7282]
["P51532-4","Isoform 4 of Transcription activator BRG1 [OS=Homo sapiens]",22,35,82,18,1617,181.6,8.07,239.68,"","","","SMARCA4","","","","",3725.9,3804.6,3787,4220.1,4276.1,4964.5,0.8407809400699814,-0.2501981301284126,0.04114073605398986,1.3857279425555733,0.22224511442617287,0.6531677772692233,1353]
["P51571","translocon-associated protein subunit delta [OS=Homo sapiens]",36,5,27,5,173,19,6.15,88.66,"","other membranes;ER/Golgi;other cell component","","SSR4","ENSG00000180879","Protein processing in endoplasmic reticulum","SRP-dependent cotranslational protein targeting to membrane","VEGFA-VEGFR2 signaling pathway",3772.4,4428.6,4373.1,4479.7,3627.5,4815.3,0.9730392725865739,-0.039430060464232676,0.7916526040599511,0.10146535532729249,0.8677547815048264,0.06160298459928724,6668]
["P51648","Fatty aldehyde dehydrogenase [OS=Homo sapiens]",14,7,18,7,485,54.8,7.88,52.73,"other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","ALDH3A2","ENSG00000072210","Glycolysis / Gluconeogenesis; Ascorbate and aldarate metabolism; Fatty acid degradation; Valine, leucine and isoleucine degradation; Lysine degradation; Arginine and proline metabolism; Histidine metabolism; Tryptophan metabolism; beta-Alanine metabolism; Glycerolipid metabolism; Pyruvate metabolism; Pantothenate and CoA biosynthesis; Metabolic pathways; Biosynthesis of cofactors; Alcoholic liver disease","RND2 GTPase cycle; RND1 GTPase cycle","Fragile X syndrome; Tryptophan metabolism; Fluoroacetic acid toxicity",1747.3,1757.6,1727.9,1589.3,1572.7,1107,1.2257671585851486,0.2936849569590593,0.11229922455011764,0.9496232426233833,0.356247843852782,0.4482477554905847,2304]
["P51692","Signal transducer and activator of transcription 5B [OS=Homo sapiens]",10,8,12,8,787,89.8,6.05,26.85,"other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","STAT5B","ENSG00000173757","ErbB signaling pathway; Chemokine signaling pathway; Necroptosis; JAK-STAT signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; Prolactin signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Growth hormone synthesis, secretion and action; Hepatitis B; Measles; Human T-cell leukemia virus 1 infection; Pathways in cancer; Viral carcinogenesis; Chemical carcinogenesis; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer","Interleukin-3, Interleukin-5 and GM-CSF signaling; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Growth hormone receptor signaling; Signaling by Leptin; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Signaling by cytosolic FGFR1 fusion mutants; Prolactin receptor signaling; Interleukin-20 family signaling; Erythropoietin activates STAT5; Signaling by FLT3 fusion proteins; Interleukin-2 signaling; STAT5 activation downstream of FLT3 ITD mutants; Interleukin-15 signaling; Interleukin-9 signaling; Interleukin-21 signaling; STAT5 Activation","IL-5 signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; AGE/RAGE pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Chemokine signaling pathway; IL-4 signaling pathway; White fat cell differentiation; Non-small cell lung cancer; EGF/EGFR signaling pathway; Hepatitis B infection; Endochondral ossification; Endochondral ossification with skeletal dysplasias; IL-2 signaling pathway; 3q29 copy number variation syndrome; FOXP3 in COVID-19; Familial partial lipodystrophy (FPLD); EPO receptor signaling; ErbB signaling pathway",1214.3,1366.7,1403.1,1425.5,1253.5,2078.6,0.8374180258954094,-0.2559801216503019,0.3739915908848597,0.42713816270155286,0.5937238353122155,0.22641551577533403,4604]
["P51795-2","Isoform 2 of H(+)/Cl(-) exchange transporter 5 [OS=Homo sapiens]",4,5,9,4,816,90.7,6.19,13.15,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","CLCN5","ENSG00000171365; ENSPPAG00000029912; ENSPTRG00000021899","Neutrophil extracellular trap formation","Stimuli-sensing channels","",696.7,786.6,735.3,820.8,782.3,1491.8,0.7168567643542604,-0.4802432130583523,0.2761571879100577,0.5588436483336656,0.5297724111376934,0.27591066212531196,3810]
["P51946","Cyclin-H [OS=Homo sapiens]",5,2,3,2,323,37.6,7.15,2.43,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","enzyme regulator activity","CCNH","ENSG00000134480","Basal transcription factors; Nucleotide excision repair; Cell cycle","RUNX1 regulates transcription of genes involved in differentiation of HSCs; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Formation of Incision Complex in GG-NER; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry","Cell cycle; Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum",257.7,273.7,278.6,285.1,349.3,195.6,0.9759036144578312,-0.03518942846230015,0.8894276934742226,0.05088935235976499,0.9281591964024976,0.03237752788720054,7004]
["P51948-1","CDK-activating kinase assembly factor MAT1 [OS=Homo sapiens]",20,4,5,4,309,35.8,6.09,14,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","nucleus","enzyme regulator activity;kinase activity;other molecular function","MNAT1","ENSCANG00000033478; ENSCATG00000030975; ENSCSAG00000014164; ENSG00000020426; ENSMFAG00000000901; ENSMMUG00000001642; ENSNLEG00000013781; ENSPPAG00000033622; ENSPTRG00000006412; ENSRROG00000035712","Basal transcription factors; Nucleotide excision repair","RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of Incision Complex in GG-NER; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry","Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; Eukaryotic transcription initiation; G1 to S cell cycle control",180.2,216.9,219.6,215.9,220.4,250.3,0.8981939994174193,-0.15490101097923867,0.23481607270795768,0.6292721797861089,0.4946025001217472,0.30574369269300966,3470]
["P52272","Heterogeneous nuclear ribonucleoprotein M [OS=Homo sapiens]",64,43,419,43,730,77.5,8.7,1152.55,"RNA metabolism OR transcription;other metabolic processes;stress response","nucleus;other cell component","nucleic acid binding activity;other molecular function","HNRNPM","ENSG00000099783","Spliceosome","mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA","mRNA processing",52527.3,52210.5,51638.7,52427.7,50947.1,50203.6,1.0182193589723556,0.026048400323396337,0.2555534856703776,0.5925181910261508,0.5122985262657131,0.2904768934611353,3646]
["P52429","Diacylglycerol kinase epsilon [OS=Homo sapiens]",8,6,11,6,567,63.9,7.74,27.76,"other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","kinase activity;other molecular function","DGKE","ENSG00000153933","Glycerolipid metabolism; Glycerophospholipid metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Phospholipase D signaling pathway; Choline metabolism in cancer","Effects of PIP2 hydrolysis","Ciliary landscape",1752.2,1783.5,1725.8,1676.9,1800.3,1397.8,1.0792820512820511,0.11007193694026847,0.3442198949206846,0.4631640323100986,0.5790341109264174,0.23729585121081095,4345]
["P52565-1","rho GDP-dissociation inhibitor 1 [OS=Homo sapiens]",40,9,172,9,204,23.2,5.11,548.54,"signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","ARHGDIA; HEL-S-47e","ENSCATG00000044701; ENSG00000141522; ENSGGOG00000011564; ENSMLEG00000000660; ENSMMUG00000009949; ENSMNEG00000037888; ENSPPAG00000035710; ENSPPYG00000008748; ENSPTRG00000009773; ENSRBIG00000034513; ENSRROG00000034509","Neurotrophin signaling pathway; Vasopressin-regulated water reabsorption","CDC42 GTPase cycle; RAC1 GTPase cycle; RHOC GTPase cycle; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOH GTPase cycle; Axonal growth stimulation; Axonal growth inhibition (RHOA activation)","Ciliary landscape; Nephrotic syndrome",30874.4,31591.1,32088.7,28457.1,27496.4,17242,1.2918034578628468,0.3693865871092644,0.11958835812239012,0.9223110966795218,0.36694849266018026,0.43539489194230757,2382]
["P52739","Zinc finger protein 131 [OS=Homo sapiens]",10,5,6,5,623,71.4,5.19,18.71,"other biological processes","cytoskeleton;nucleus","nucleic acid binding activity;other molecular function","ZNF131","ENSG00000172262","","SUMOylation of transcription cofactors","",329.1,296.7,288.6,293.3,339.5,332.8,{"$f":"AVERAGE(S2114:U2114)/AVERAGE(V2114:X2114)","v":0.9469759734879869},{"$f":"LOG(Y2114,2)","v":-0.07860027254054303},{"$f":"TTEST(V2114:X2114,S2114:U2114,2,2)","v":0.4197442931514803},0.37701519982283704,{"$f":"AA2114*7309/AE2114","v":0.618156566319599},0.2089015131361874,4963]
["P52815","39S ribosomal protein L12, mitochondrial [OS=Homo sapiens]",39,5,53,5,198,21.3,8.87,149.17,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL12","ENSG00000262814","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",2854.9,2862.7,3810.5,3429.4,4231.8,3108.5,0.8847135946219485,-0.17671760296020395,0.4197776572056501,0.3769806805952664,0.6180811636817277,0.20895449153798565,4964]
["P52907","F-actin-capping protein subunit alpha-1 [OS=Homo sapiens]",69,14,178,11,286,32.9,5.69,709.15,"cell organization and biogenesis","non-structural extracellular;cytosol;cytoskeleton;other cell component","cytoskeletal activity","CAPZA1","ENSG00000116489","Endocytosis","MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Sensory processing of sound by inner hair cells of the cochlea; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Factors involved in megakaryocyte development and platelet production; Advanced glycosylation endproduct receptor signaling","",15812.6,16414.7,15476.3,15009.1,14704.6,16070,1.0419341381321303,0.0592640860682314,0.2669758714851697,0.5735279871536221,0.5218846335076506,0.2824254904238687,3739]
["P53365","Arfaptin-2 [OS=Homo sapiens]",23,4,6,3,341,37.8,6.04,24.62,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","other molecular function","ARFIP2","ENSG00000132254","","Retrograde transport at the Trans-Golgi-Network","",529,448,497,423.4,474.8,216.9,1.321854542193525,0.4025634303995179,0.21950763421615022,0.6585503709102768,0.4799226139652533,0.3188287856188724,3343]
["P53370","Nucleoside diphosphate-linked moiety X motif 6 [OS=Homo sapiens]",3,1,2,1,316,35.7,8,4.1,"other biological processes","mitochondrion;nucleus;other cell component","other molecular function","NUDT6","ENSG00000170917","","","",143.5,111.3,155.9,128.2,127.2,96.3,1.1677566107477964,0.22373961235374876,0.30972412520303017,0.5090249650194392,0.5579920214712712,0.2533720108397924,4057]
["P53621-1","coatomer subunit alpha [OS=Homo sapiens]",54,57,294,57,1224,138.3,7.66,894.15,"transport;signal transduction","non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","COPA","ENSG00000122218","","COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic","",33672.1,34216,34939.6,32776.4,32277.1,28380.5,1.1005383479247384,0.1382094163761826,0.09489094097352985,1.0227752467191789,0.33058049932103417,0.4807227686927449,2098]
["P53701","Cytochrome c-type heme lyase [OS=Homo sapiens]",65,16,41,16,268,30.6,6.68,118.25,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes","other membranes;mitochondrion","other molecular function","HCCS","ENSG00000004961","Porphyrin and chlorophyll metabolism; Metabolic pathways","","",3753.3,3801.4,3856.5,4182.2,4152.7,4524.2,0.8874026953674832,-0.1723391597285541,0.017142225695270418,1.7659327912564067,0.1518697304324018,0.8185287779223589,825]
["P53801","pituitary tumor-transforming gene 1 protein-interacting protein [OS=Homo sapiens]",8,2,6,2,180,20.3,8.79,13.57,"transport;other biological processes","other membranes;nucleus;other cell component","other molecular function","PTTG1IP","ENSG00000183255","","","",1108,923,1001.7,781.5,865.6,472.3,1.4309238463716145,0.5169468940174061,0.0808496283928233,1.0923219718901362,0.3087408223213926,0.5104059434469881,1914]
["P54105","Methylosome subunit pICln [OS=Homo sapiens]",35,5,13,5,237,26.2,4.11,50.27,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","","CLNS1A","ENSG00000074201","","snRNP Assembly","",513.2,503.9,516.1,615,667.2,974.6,0.6793690180786954,-0.5577326677850537,0.09810300277618199,1.0083176993563616,0.334437895191751,0.47568451849312104,2144]
["P54274-1","telomeric repeat-binding factor 1 [OS=Homo sapiens]",3,1,1,1,439,50.2,6.37,2.11,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;nucleic acid binding activity;other molecular function","TERF1","ENSG00000147601","","Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Meiotic synapsis; Inhibition of DNA recombination at telomere; Packaging Of Telomere Ends; DNA Damage/Telomere Stress Induced Senescence; Telomere Extension By Telomerase; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; Removal of the Flap Intermediate from the C-strand","",59.6,63.8,72.6,87.5,86.9,61.5,0.8308605341246289,-0.26732176423689236,0.22942372725361457,0.6393616689001398,0.48959358321070623,0.3101642828446112,3425]
["P54296","Myomesin-2 [OS=Homo sapiens]",6,7,9,7,1465,164.8,6.19,23.9,"cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYOM2","ENSG00000036448; ENSG00000274137","","","",324.7,389.7,357.2,390.1,376,386.4,0.9298047722342733,-0.1050002643616837,0.2335135477478657,0.6316879179181712,0.49399436193607826,0.30627800774441555,3455]
["P54802","alpha-N-acetylglucosaminidase [OS=Homo sapiens]",19,10,20,10,743,82.2,6.65,57.38,"cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","non-structural extracellular;other cytoplasmic organelle","other molecular function","NAGLU","ENSG00000108784","Glycosaminoglycan degradation; Metabolic pathways; Lysosome","HS-GAG degradation; MPS IIIB - Sanfilippo syndrome B","Glycosaminoglycan degradation",1717.1,1712.7,1746.8,1615,1596.3,1945.3,1.0038785246092388,0.005584704999155324,0.9561139309933705,{"$f":"-LOG10(AA2179)","v":0.01949035390212696},0.9723440547697989,{"$f":"-LOG10(AC2179)","v":0.012180036874901863},7187]
["P54852","Epithelial membrane protein 3 [OS=Homo sapiens]",10,1,3,1,163,18.4,7.96,10.84,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes","","EMP3","ENSG00000142227","","","",201.9,226.8,207.4,182.8,180.6,253.8,1.0306221646143874,0.043515524612516336,0.8149018536636201,0.0888946943017857,0.8838281122462383,0.05363218878951507,6739]
["P55039","Developmentally-regulated GTP-binding protein 2 [OS=Homo sapiens]",35,11,41,10,364,40.7,8.88,108.5,"protein metabolism;other metabolic processes;signal transduction","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","DRG2","ENSG00000108591","","","",4031,4160.4,4170.9,3781.7,3744.8,3507.2,1.1204129167912849,0.16403052087360462,0.010318982043550346,1.9863631432780107,0.12164748347791852,0.9148968708922917,620]
["P55145","Mesencephalic astrocyte-derived neurotrophic factor [OS=Homo sapiens]",25,6,18,6,182,20.7,8.69,39.71,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;ER/Golgi;other cell component","signal transduction activity or receptor binding;other molecular function","MANF","ENSG00000145050","","Platelet degranulation","Orexin receptor pathway",1447,1338,1716.4,1561.8,1638.9,1445.8,0.9687721941246098,-0.04577063775585067,0.7199489852435274,0.14269827608563043,0.8179864966803888,0.08725386560202558,6433]
["P55197-1","Isoform 1 of Protein AF-10 [OS=Homo sapiens]",3,3,3,2,1027,109,8.38,6.62,"","","","MLLT10","","","","",226.9,195.7,231.2,299.4,316.5,265,0.7421954818935179,-0.4301288762147041,0.01585360196576569,1.799872049778395,0.14612102997198165,0.835287275212026,793]
["P55209-3","Isoform 3 of Nucleosome assembly protein 1-like 1 [OS=Homo sapiens]",47,11,262,1,323,37.3,4.67,864.92,"","","","NAP1L1","","","","",22.8,26.5,23.7,12.9,18.7,41.5,0.9986320109439125,-0.001974942185057669,0.9971589567265653,1.2356054530661836E-3,0.9982515839904761,7.5999200988090927E-4,7301]
["P55769","NHP2-like protein 1 [OS=Homo sapiens]",38,5,20,5,128,14.2,8.46,56.04,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SNU13","ENSG00000100138","Ribosome biogenesis in eukaryotes; Spliceosome","mRNA Splicing - Major Pathway; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; mRNA Splicing - Minor Pathway","mRNA processing",2264,2071.6,2522.3,2783.5,3096.2,2835.1,0.7869256896314317,-0.34570068820404815,0.018967204222391898,1.7219966796685156,0.15843576647024274,0.8001467708068557,875]
["P55795","heterogeneous nuclear ribonucleoprotein H2 [OS=Homo sapiens]",48,18,271,7,449,49.2,6.3,653.89,"other biological processes","cytosol;nucleus;other cell component","","HNRNPH2","ENSG00000126945","","mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA","mRNA processing",7109.7,7032.4,6641.6,6924.6,7277,5944.9,1.0316283225374132,0.0449232868316279,0.6427389322100947,0.19196539305377913,0.7694969460317088,0.11379309945070744,6105]
["P56181-2","Isoform 2 of NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [OS=Homo sapiens]",22,7,14,7,473,51,9.17,48.09,"","","","NDUFV3","","","","",1865.7,1527.4,1157.3,2229,1452.9,1493.4,0.8792533766158483,-0.18564912461302643,0.5561597183244917,0.2548004695224052,0.7079364996923911,0.15000569579891945,5742]
["P56270-2","Isoform 2 of Myc-associated zinc finger protein [OS=Homo sapiens]",10,5,11,4,493,51,9.1,40.42,"","","","MAZ","","","","",794.6,833.8,802.6,943.9,1055.7,1098.9,0.7845731805712443,-0.35002007494288095,0.009560712315158204,2.019509749667607,0.11744411144788457,0.9301687535121836,595]
["P56937-1","3-keto-steroid reductase [OS=Homo sapiens]",21,6,13,6,341,38.2,8.1,39.26,"other metabolic processes","other membranes;ER/Golgi","other molecular function","HSD17B7","ENSG00000132196","Steroid biosynthesis; Steroid hormone biosynthesis; Metabolic pathways; Ovarian steroidogenesis","Cholesterol biosynthesis","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Steroid biosynthesis",1107.7,1114.6,1119.4,1161.9,1221.3,1879.9,0.7838662006521075,-0.3513206754055255,0.25285228236927254,0.5971331218577879,0.5106651925496029,0.29186374308201435,3619]
["P57678","Gem-associated protein 4 [OS=Homo sapiens]",10,10,21,10,1058,120,6.04,54.82,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","GEMIN4","ENSG00000179409","","snRNP Assembly","",1944.5,2069.7,1984.3,2318.4,2202.4,2392.4,0.8676879014060058,-0.20475188178173823,0.010141751625575684,1.9938870296551117,0.12092343006742687,0.9174895422895538,613]
["P57737","Coronin-7 [OS=Homo sapiens]",52,34,178,1,925,100.5,5.8,561.51,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cell component","cytoskeletal activity","CORO7","ENSG00000262246; ENSG00000282725","","","",305.3,292.9,301.9,305.9,301.9,474.4,0.8317316577342452,-0.26580994933392954,0.34666808537398947,0.46008613810693694,0.5799489668112815,0.23661022093253248,4369]
["P58005-1","sestrin-3 [OS=Homo sapiens]",5,2,3,2,492,57.3,6.25,5.58,"stress response;signal transduction;other biological processes","nucleus;other cell component","other molecular function","SESN3","ENSG00000149212","p53 signaling pathway; Longevity regulating pathway","TP53 Regulates Metabolic Genes","Angiopoietin-like protein 8 regulatory pathway; miRNA regulation of p53 pathway in prostate cancer",163.2,189.6,151.4,97.3,104.8,164.7,1.3745910577971645,0.45900247926348525,0.13055685246941023,0.8842003286548912,0.3807821367513645,0.41932343342904943,2506]
["P60468","protein transport protein Sec61 subunit beta [OS=Homo sapiens]",36,4,39,4,96,10,11.56,58.02,"protein metabolism;other metabolic processes;stress response;transport","other membranes;cytosol;ER/Golgi","translation activity;other molecular function","SEC61B","ENSG00000106803","Protein export; Protein processing in endoplasmic reticulum; Phagosome; Vibrio cholerae infection","ER-Phagosome pathway; SRP-dependent cotranslational protein targeting to membrane; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",4629.2,4025.3,4217.9,4022.2,4432.7,3268.9,1.0979716474180727,0.13484080055671302,0.3757475240280651,0.4251038724961879,0.593931369619621,0.22626373602468766,4624]
["P60520","Gamma-aminobutyric acid receptor-associated protein-like 2 [OS=Homo sapiens]",35,5,6,5,117,13.7,8.1,15.85,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","GABARAPL2","ENSG00000034713","FoxO signaling pathway; Autophagy; Mitophagy; Autophagy; NOD-like receptor signaling pathway; GABAergic synapse","TBC/RABGAPs; Macroautophagy","Network map of SARS-CoV-2 signaling pathway; Senescence and autophagy in cancer",691.9,676.7,723.6,1131.2,1150,1962.8,0.4929783223374175,-1.0204038863042666,0.059214667687298286,1.2275707036378418,0.26262136294081506,0.5806699491149657,1648]
["P60891","ribose-phosphate pyrophosphokinase 1 [OS=Homo sapiens]",58,17,100,8,318,34.8,6.98,299.06,"other metabolic processes;developmental processes","cytosol;other cell component","kinase activity;other molecular function","PRPS1","ENSG00000147224","Pentose phosphate pathway; Purine metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids","5-Phosphoribose 1-diphosphate biosynthesis","Nucleotide metabolism",14245.1,14133.6,14610.6,12683.6,11950.9,10499,1.2235985597791283,0.29113031390419924,0.016397514229552386,1.7852219835505865,0.1490664570942766,0.8266200704150649,804]
["P60953","Cell division control protein 42 homolog [OS=Homo sapiens]",48,8,143,2,191,21.2,6.55,517.75,"cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","CDC42","ENSG00000070831","MAPK signaling pathway; Ras signaling pathway; Rap1 signaling pathway; Chemokine signaling pathway; Endocytosis; Axon guidance; VEGF signaling pathway; Focal adhesion; Adherens junction; Tight junction; T cell receptor signaling pathway; Fc gamma R-mediated phagocytosis; Leukocyte transendothelial migration; Neurotrophin signaling pathway; Regulation of actin cytoskeleton; GnRH signaling pathway; Non-alcoholic fatty liver disease; AGE-RAGE signaling pathway in diabetic complications; Bacterial invasion of epithelial cells; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Human papillomavirus infection; Pathways in cancer; Viral carcinogenesis; Proteoglycans in cancer; Renal cell carcinoma; Pancreatic cancer; Lipid and atherosclerosis","RHO GTPases Activate Formins; MAPK6/MAPK4 signaling; RHO GTPases activate IQGAPs; RAC1 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; GPVI-mediated activation cascade; CDC42 GTPase cycle; RHOG GTPase cycle; RAC3 GTPase cycle; RHOQ GTPase cycle; RAC2 GTPase cycle; RHOJ GTPase cycle; EPHB-mediated forward signaling; DCC mediated attractive signaling; Myogenesis; G beta:gamma signalling through CDC42; EGFR downregulation; RHO GTPases activate PAKs; Inactivation of CDC42 and RAC1; CD28 dependent Vav1 pathway; RHO GTPases activate KTN1","Androgen receptor signaling pathway; Target of rapamycin (TOR) signaling; Integrin-mediated cell adhesion; Integrated breast cancer pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; Microtubule cytoskeleton regulation; Metastatic brain tumor; Pathogenic Escherichia coli infection; RalA downstream regulated genes; B cell receptor signaling pathway; AGE/RAGE pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Focal adhesion; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; Oxidative damage response; p38 MAPK signaling pathway; Ebola virus pathway in host; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Hippo signaling regulation pathways; 22q11.2 copy number variation syndrome; Gastrin signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent)",13978.7,12926.2,13282.4,11551.8,12429.2,6408.7,1.322398707456803,0.4031572196199276,0.16127646424183423,0.792429006421902,0.41904361078690594,0.37774077670312994,2813]
["P61020","Ras-related protein Rab-5B [OS=Homo sapiens]",66,9,33,6,215,23.7,8.13,109.45,"transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","RAB5B","ENSG00000111540","Ras signaling pathway; Endocytosis; Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection; Amoebiasis; Tuberculosis","RAB geranylgeranylation; Neutrophil degranulation; Clathrin-mediated endocytosis; RAB GEFs exchange GTP for GDP on RABs; TBC/RABGAPs","Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells",1390,1424.3,1307.4,1114.8,1176.2,1743.8,1.0215376226826611,0.030742338734059547,0.8935373695727334,0.048887279689001716,0.930720341200956,0.031180794333844252,7017]
["P61160-1","Actin-related protein 2 [OS=Homo sapiens]",36,11,110,11,394,44.7,6.74,332.6,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","Actr2; ACTR2; LOC111147990","ENSAMEG00000015749; ENSANAG00000038066; ENSBIXG00000015264; ENSBIXG00005008678; ENSBTAG00000009761; ENSCAFG00000003197; ENSCATG00000036025; ENSCCAG00000030047; ENSCHIG00000014272; ENSCJAG00000006722; ENSCPOG00000025808; ENSDLEG00000013424; ENSECAG00000009219; ENSFCAG00000004960; ENSG00000138071; ENSHGLG00000013085; ENSLAFG00000010273; ENSLCNG00005006073; ENSMFAG00000044097; ENSMLEG00000038155; ENSMLUG00000005227; ENSMMUG00000002263; ENSMNEG00000044163; ENSMPUG00000006176; ENSMUSG00000020152; ENSNLEG00000009948; ENSOANG00000039143; ENSOCUG00000004906; ENSPANG00000007073; ENSPCOG00000025808; ENSPCTG00005007920; ENSPPAG00000030634; ENSPPYG00000012359; ENSPTRG00000011990; ENSRBIG00000040326; ENSRFEG00010007536; ENSRROG00000043956; ENSSBOG00000028028; ENSSSUG00005000856; ENSSTOG00000012608; ENSTSYG00000034470; ENSVURG00010013014; ENSVVUG00000027598","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Salmonella infection; Yersinia infection; Pathogenic Escherichia coli infection; Shigellosis","Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; EPHB-mediated forward signaling; Regulation of actin dynamics for phagocytic cup formation; Neutrophil degranulation; EPHB-mediated forward signaling; Clathrin-mediated endocytosis; RHO GTPases Activate WASPs and WAVEs","ESC pluripotency pathways; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways",14926.5,14731.2,14819,13217.8,13253.1,13396.9,1.115604573114142,0.15782575342254457,4.0549386988486579E-5,4.392015706915957,0.017433851146991083,1.7586066664102575,17]
["P61201-1","COP9 signalosome complex subunit 2 [OS=Homo sapiens]",44,17,60,1,443,51.6,5.53,181.37,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","Cops2; COPS2; LOC101356833; LOC111162519","ENSACCG00020011181; ENSANAG00000033255; ENSBIXG00000019496; ENSBIXG00005014970; ENSCHIG00000021490; ENSCPOG00000003447; ENSCSAG00000010648; ENSDLEG00000002228; ENSG00000166200; ENSGALG00000000404; ENSLSDG00000017105; ENSMMUG00000009838; ENSMPUG00000012327; ENSMUSG00000027206; ENSOARG00000021006; ENSPPYG00000006460; ENSPSIG00000010252; ENSRNOG00000008744; ENSSHBG00005020299; ENSSSCG00000004652; ENSSSCG00070002171; ENSSTOG00000005348; ENSUMAG00000014609","","Cargo recognition for clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER; Formation of TC-NER Pre-Incision Complex; RHOBTB1 GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; Neddylation; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER; RHOBTB1 GTPase cycle; Neddylation; DNA Damage Recognition in GG-NER; Formation of TC-NER Pre-Incision Complex; Cargo recognition for clathrin-mediated endocytosis; RHOBTB1 GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; Neddylation; Formation of TC-NER Pre-Incision Complex; RHOBTB1 GTPase cycle; DNA Damage Recognition in GG-NER","Ciliary landscape",5510.3,5540.8,5414.5,5809.3,5670.5,4886.1,1.0060919350600943,0.008762142315552396,0.9142609022304493,0.03892985215448549,0.943965663851159,0.025043802599362612,7079]
["P61313-1","60S ribosomal protein L15 [OS=Homo sapiens]",50,12,68,12,204,24.1,11.62,207.71,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;cytoskeleton;translational apparatus;nucleus","nucleic acid binding activity;other molecular function","LOC111155115; NR1D2; Rpl15; RPL15","ENSAMEG00000003497; ENSAMEG00000024645; ENSBIXG00000012476; ENSBIXG00005007092; ENSBMUG00000012295; ENSBTAG00000033080; ENSCAFG00000005764; ENSCAFG00030022972; ENSCAFG00040022162; ENSCANG00000040764; ENSCATG00000039291; ENSCGRG00001021972; ENSCGRG00015016653; ENSCJAG00000043224; ENSCPOG00000030042; ENSCSAG00000009762; ENSECAG00000010157; ENSFCAG00000026237; ENSG00000174748; ENSGGOG00000024274; ENSHGLG00000000795; ENSLCNG00005011910; ENSMFAG00000043886; ENSMLEG00000031741; ENSMLUG00000013809; ENSMMUG00000006353; ENSMPUG00000012148; ENSMUSG00000012405; ENSNLEG00000003580; ENSOANG00000045456; ENSOCUG00000010961; ENSOGAG00000013056; ENSPANG00000015926; ENSPPAG00000032386; ENSPPYG00000014065; ENSPTRG00000014695; ENSRBIG00000024014; ENSRBIG00000033415; ENSRFEG00010011144; ENSRNOG00000008140; ENSRROG00000001983; ENSRROG00000015533; ENSRROG00000027506; ENSRROG00000028991; ENSRROG00000037650; ENSSHAG00000031281; ENSSSCG00000037030; ENSSSCG00070018008; ENSSSUG00005002593; ENSSTOG00000011153; ENSUAMG00000015536; ENSVURG00010022414; ENSVVUG00000028235","Ribosome; Coronavirus disease","L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; SRP-dependent cotranslational protein targeting to membrane; Formation of a pool of free 40S subunits; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; Formation of a pool of free 40S subunits; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins; Cytoplasmic ribosomal proteins; Cytoplasmic ribosomal proteins",12134,10633.1,10020.7,12974.8,14214.9,14247.5,0.7912648538028633,-0.33776741749445527,0.01877491728314409,1.72642196769547,0.15809432076324903,0.8010837309879889,868]
["P61626","lysozyme c [OS=Homo sapiens]",6,1,1,1,148,16.5,9.16,2.6,"other metabolic processes;stress response;other biological processes","non-structural extracellular;other cytoplasmic organelle;other cell component","other molecular function","LYZ","ENSG00000090382","Salivary secretion","Neutrophil degranulation; Amyloid fiber formation; Antimicrobial peptides","Macrophage markers",143.6,94,64.2,182,101.8,59.1,0.8801399825021872,-0.1841950984089512,0.7650540256886973,0.11630789526465772,0.8495563466664674,0.07080781133903953,6582]
["P61769","Beta-2-microglobulin [OS=Homo sapiens]",8,1,2,1,119,13.7,6.52,6.3,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","B2M","ENSG00000166710; ENSG00000273686","Antigen processing and presentation; Human cytomegalovirus infection; Human T-cell leukemia virus 1 infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection","ER-Phagosome pathway; Neutrophil degranulation; DAP12 signaling; Amyloid fiber formation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Modulation by Mtb of host immune system; Nef mediated downregulation of MHC class I complex cell surface expression; Endosomal/Vacuolar pathway","IL-18 signaling pathway",177.2,207.8,174,195.3,155.6,152.7,1.1100079428117555,0.15057000001153614,0.3498936365896174,0.4560639558284551,0.5821471863950635,0.23496719720980258,4393]
["P61962","DDB1- and CUL4-associated factor 7 [OS=Homo sapiens]",17,5,9,5,342,38.9,5.52,25.48,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","DCAF7","ENSG00000136485","","Neddylation; Association of TriC/CCT with target proteins during biosynthesis","Ciliary landscape",1079.6,1025,956.7,945.7,1042,1795.7,0.8091399270497436,-0.3055388809780086,0.4247258412841878,0.37189131474345516,0.6207400867718713,0.20709020740714998,5001]
["P61970","nuclear transport factor 2 [OS=Homo sapiens]",74,6,40,6,127,14.5,5.38,113.91,"transport;other biological processes","other membranes;cytosol;nucleus","other molecular function","NUTF2","ENSG00000102898","","","",6516.2,6042.9,6282.2,5978.4,6305.2,5754.3,1.0445395528304295,0.06286712293821846,0.27195967448593084,0.5654954873135194,0.5258606510099652,0.27912932526677187,3780]
["P62136-1","serine/threonine-protein phosphatase PP1-alpha catalytic subunit [OS=Homo sapiens]",59,15,107,4,330,37.5,6.33,384.55,"cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","LOC111149674; Ppp1ca; PPP1CA","ENSAMEG00000000758; ENSANAG00000023829; ENSBIXG00000010347; ENSBIXG00005003445; ENSBTAG00000012146; ENSCAFG00000041420; ENSCATG00000031120; ENSCCAG00000020614; ENSCHIG00000012800; ENSCJAG00000000983; ENSCPOG00000032835; ENSCSAG00000008548; ENSECAG00000010532; ENSFCAG00000028502; ENSG00000172531; ENSGGOG00000009981; ENSHGLG00000013028; ENSLCNG00005013643; ENSMLUG00000005112; ENSMMUG00000017278; ENSMNEG00000042253; ENSMPUG00000003801; ENSNLEG00000006360; ENSOARG00000011318; ENSOGAG00000033516; ENSPANG00000009836; ENSPCOG00000026258; ENSPCTG00005022585; ENSPPYG00000002995; ENSRFEG00010000614; ENSRNOG00000018708; ENSSHAG00000030720; ENSSSCG00000012913; ENSSSCG00070006658; ENSVURG00010024750; ENSVVUG00000010423","mRNA surveillance pathway; cGMP-PKG signaling pathway; cAMP signaling pathway; Oocyte meiosis; Cellular senescence; Adrenergic signaling in cardiomyocytes; Vascular smooth muscle contraction; Hippo signaling pathway; Focal adhesion; Platelet activation; Long-term potentiation; Dopaminergic synapse; Inflammatory mediator regulation of TRP channels; Regulation of actin cytoskeleton; Insulin signaling pathway; Oxytocin signaling pathway; Insulin resistance; Amphetamine addiction; Alcoholism; Herpes simplex virus 1 infection; Proteoglycans in cancer; Diabetic cardiomyopathy","DARPP-32 events; Circadian Clock; Triglyceride catabolism; Downregulation of TGF-beta receptor signaling; DARPP-32 events; DARPP-32 events","Sphingolipid pathway; Nicotine effect on dopaminergic neurons; Common pathways underlying drug addiction; Vascular smooth muscle contraction; Focal adhesion; VEGFA-VEGFR2 signaling pathway; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Netrin-UNC5B signaling pathway; Neuroinflammation and glutamatergic signaling",3227.6,3030.4,2987.8,3137.1,3261,2542.7,1.0341132784538296,0.048394229475152296,0.6859446773322709,0.1637109095092485,0.7970698961242557,0.09850359307054443,6290]
["P62256","ubiquitin-conjugating enzyme E2 H [OS=Homo sapiens]",28,6,8,6,183,20.6,4.67,23.56,"protein metabolism;other metabolic processes","cytosol;nucleus","other molecular function","UBE2H","ENSG00000186591","Ubiquitin mediated proteolysis","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation","Ciliary landscape",1663,1673,1703.6,1962.5,1783.9,832,1.1007338808317317,0.13846571757537704,0.6840823348461047,0.1648916242778533,0.7961716218774171,0.09899330613107647,6280]
["P62266","40S ribosomal protein S23 [OS=Homo sapiens]",52,7,57,7,143,15.8,10.49,177.3,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytosol;ER/Golgi;translational apparatus;nucleus;other cell component","other molecular function","RPS23","ENSG00000186468","Ribosome; Coronavirus disease","Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",7910.7,7924.1,7901.3,8889.7,8621.3,8194.3,0.9233932301898831,-0.11498293950602373,0.03167059662564401,1.4993437551066384,0.19835509060568302,0.7025566492680356,1167]
["P62312","U6 snRNA-associated Sm-like protein LSm6 [OS=Homo sapiens]",43,4,6,4,80,9.1,9.58,13.28,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","LSM6","ENSG00000164167","RNA degradation; Spliceosome","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease","",1343.8,1246.3,1560.9,1337.1,1379.1,1448.8,0.996638655462185,-4.8575636493020345E-3,0.9644907510612757,0.01570193264664998,0.9786842842575127,0.009357385539366754,7203]
["P62487","DNA-directed RNA polymerase II subunit rpb7 [OS=Homo sapiens]",38,5,9,5,172,19.3,5.54,24.31,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","POLR2G","ENSG00000168002","RNA polymerase; Huntington disease","FGFR2 alternative splicing; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere","Pyrimidine metabolism; Eukaryotic transcription initiation",884.5,880.9,878.2,996.7,965.9,1294.6,0.811617340046666,-0.3011284065644802,0.12279487531834968,0.9108197575222393,0.37071777930682276,0.4309565850799992,2421]
["P62633-1","Cellular nucleic acid-binding protein [OS=Homo sapiens]",50,9,54,1,177,19.5,7.71,136.79,"DNA metabolism;other metabolic processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","Cnbp; CNBP; LOC101344172; LOC111159043; LOC113917796","ENSAMEG00000015334; ENSBIXG00000009042; ENSBMUG00000014129; ENSCAFG00000004320; ENSCANG00000042967; ENSCATG00000020089; ENSCCAG00000034056; ENSCGRG00001000923; ENSCJAG00000017430; ENSCPOG00000032294; ENSCSAG00000008817; ENSDLEG00000010302; ENSECAG00000009512; ENSFCAG00000042197; ENSG00000169714; ENSHGLG00000002069; ENSLAFG00000002502; ENSLCNG00005005148; ENSMFAG00000030262; ENSMLEG00000041892; ENSMMUG00000058753; ENSMNEG00000028473; ENSMPUG00000017315; ENSNLEG00000035879; ENSOCUG00000008696; ENSPANG00000007815; ENSPCTG00005021559; ENSPPYG00000013423; ENSPTRG00000015369; ENSRBIG00000030361; ENSRNOG00000010239; ENSRROG00000045469; ENSSBOG00000023735; ENSSSCG00070013675; ENSSTOG00000000173; ENSTSYG00000004344; ENSTTRG00000015266; ENSVVUG00000018264","","","",4899.4,4790.8,4738.3,8275.2,7904.2,6269.5,0.6427263696662197,-0.6377234306562015,0.012384367102043185,1.9071261829508563,0.13156589992563028,0.8808566593023948,688]
["P62753","40S RIBOSOMAL PROTEIN S6 [OS=Homo sapiens]",43,13,163,13,249,28.7,10.84,526.71,"cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;ER/Golgi;translational apparatus;nucleus;other cell component","other molecular function","RPS6","ENSG00000137154","EGFR tyrosine kinase inhibitor resistance; Ribosome; HIF-1 signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Apelin signaling pathway; Thermogenesis; Insulin signaling pathway; Coronavirus disease; Proteoglycans in cancer","L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); mTORC1-mediated signalling; rRNA modification in the nucleus and cytosol; Nuclear events stimulated by ALK signaling in cancer","IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Thermogenesis; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Cytoplasmic ribosomal proteins; EGFR tyrosine kinase inhibitor resistance; IL-2 signaling pathway; Malignant pleural mesothelioma; Interferon type I signaling pathways",17568.9,17650.9,17584,18514.7,17848.3,17554.3,0.9793480014763349,-0.030106496761586127,0.2630389006275355,0.5799800192723149,0.5198894874761106,0.28408896421149615,3698]
["P62826","GTP-binding nuclear protein RAN [OS=Homo sapiens]",66,10,91,10,216,24.4,7.49,277.36,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;other biological processes","cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RAN","ENSG00000132341","Ribosome biogenesis in eukaryotes; Nucleocytoplasmic transport; Human T-cell leukemia virus 1 infection","Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Nuclear import of Rev protein; Transcriptional regulation by small RNAs; tRNA processing in the nucleus; Regulation of cholesterol biosynthesis by SREBP (SREBF); MicroRNA (miRNA) biogenesis; Postmitotic nuclear pore complex (NPC) reformation","Androgen receptor signaling pathway; miRNA biogenesis; 22q11.2 copy number variation syndrome",12293.9,13080.3,13657.9,11756.3,11128.9,11932.9,1.1210290050289935,0.16482360630581955,0.03900947626692967,1.408829880395958,0.21649222629839704,0.664557693473769,1317]
["P62854","40S ribosomal protein S26 [OS=Homo sapiens]",21,2,7,2,115,13,11,24.57,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;translational apparatus;nucleus","nucleic acid binding activity;other molecular function","RPS26","ENSG00000197728","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Peptide chain elongation; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",671,631.6,852.5,719.6,669.4,815.8,0.9774582728592162,-0.03289297898809177,0.8469051395999394,0.07216523152930923,0.9029948454173534,0.04431472877086769,6855]
["P62913","60S ribosomal protein L11 [OS=Homo sapiens]",49,8,53,8,178,20.2,9.6,142.44,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;translational apparatus;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","RPL11","ENSG00000142676","Ribosome; Coronavirus disease","Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",8132.4,7583.7,9263.6,9705.4,9531.4,4948.7,1.032837857393893,0.04661378692879557,0.8791497493123346,0.055937143400822294,0.9225707850285504,0.03500030227683162,6965]
["P62937-2","Isoform 2 of Peptidyl-prolyl cis-trans isomerase A [OS=Homo sapiens]",90,12,899,1,105,11.4,7.9,1952.98,"","","","PPIA","","","","",596.3,908.8,1087.2,461.9,292.7,159.7,2.835283823690255,1.503493162163927,0.029129663151888245,1.5356645374156561,0.19060761681034125,0.7198597486472922,1117]
["P63027","Vesicle-associated membrane protein 2 [OS=Homo sapiens]",34,4,16,1,116,12.7,8.13,54.84,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","VAMP2","ENSG00000220205","SNARE interactions in vesicular transport; Synaptic vesicle cycle; Insulin secretion; Vasopressin-regulated water reabsorption; Salivary secretion","Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; GABA synthesis, release, reuptake and degradation; Cargo recognition for clathrin-mediated endocytosis; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Sensory processing of sound by inner hair cells of the cochlea; Lysosome Vesicle Biogenesis; trans-Golgi Network Vesicle Budding; Golgi Associated Vesicle Biogenesis; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; Regulation of insulin secretion; Insulin processing; Other interleukin signaling; Toxicity of tetanus toxin (tetX); Toxicity of botulinum toxin type B (botB); Toxicity of botulinum toxin type D (botD); Toxicity of botulinum toxin type G (botG); Toxicity of botulinum toxin type F (botF)","Synaptic vesicle pathway; Insulin signaling; 7q11.23 copy number variation syndrome; Galanin receptor pathway; Sudden infant death syndrome (SIDS) susceptibility pathways",1259,1326.8,1294.2,1288,1639.9,2775.2,0.6803317493994493,-0.5556896771984707,0.24748099406259189,0.6064581482079149,0.5065355882395642,0.2953900365167239,3571]
["P63208","s-phase kinase-associated protein 1 [OS=Homo sapiens]",63,10,50,10,163,18.6,4.54,140.14,"protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","SKP1","ENSG00000113558","Cell cycle; Oocyte meiosis; Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum; Wnt signaling pathway; TGF-beta signaling pathway; Circadian rhythm; Shigellosis; Salmonella infection; Human immunodeficiency virus 1 infection; Pathways in cancer","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Regulation of RUNX2 expression and activity; Circadian Clock; Antigen processing: Ubiquitination & Proteasome degradation; Nuclear events stimulated by ALK signaling in cancer; SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Neddylation; SCF(Skp2)-mediated degradation of p27/p21; Negative regulation of NOTCH4 signaling; Regulation of PLK1 Activity at G2/M Transition; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Cyclin D associated events in G1; Regulation of BACH1 activity; MAP3K8 (TPL2)-dependent MAPK1/3 activation; NOTCH1 Intracellular Domain Regulates Transcription; Prolactin receptor signaling; Iron uptake and transport; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling","Cell cycle; TNF-alpha signaling pathway; TGF-beta signaling pathway; Breast cancer pathway; Small cell lung cancer; Notch signaling pathway (Netpath)",3598.3,3132.1,5177.1,5491.8,6301.1,4832,0.7162449097438178,-0.481475114020886,0.1042383147719709,0.9819726185075781,0.344118266787866,0.46329227316630917,2214]
["P63279","SUMO-conjugating enzyme ubc9 [OS=Homo sapiens]",25,2,5,2,158,18,8.66,15.5,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","UBE2I","ENSG00000103275","Nucleocytoplasmic transport; NF-kappa B signaling pathway; Ubiquitin mediated proteolysis; MicroRNAs in cancer","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; Formation of Incision Complex in GG-NER; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; SUMOylation of intracellular receptors; Vitamin D (calciferol) metabolism; SUMOylation of transcription factors; Postmitotic nuclear pore complex (NPC) reformation; Negative regulation of activity of TFAP2 (AP-2) family transcription factors; Maturation of nucleoprotein; SUMOylation of immune response proteins; Maturation of nucleoprotein; SUMO is transferred from E1 to E2 (UBE2I, UBC9)","Androgen receptor signaling pathway; TGF-beta signaling pathway",548.1,501.4,777.7,740,735.9,271.4,1.0457276941566989,0.06450722497432335,0.8879395251691591,0.05161661167599828,0.9272681796630067,0.03279464330544038,6999]
["P67936","Tropomyosin alpha-4 chain [OS=Homo sapiens]",59,19,105,8,248,28.5,4.69,249.85,"cell organization and biogenesis;other biological processes","cytosol;cytoskeleton","cytoskeletal activity;other molecular function","TPM4","ENSG00000167460","Cardiac muscle contraction; Adrenergic signaling in cardiomyocytes; Hypertrophic cardiomyopathy; Dilated cardiomyopathy","Smooth Muscle Contraction; Striated Muscle Contraction; RHOV GTPase cycle; Signaling by ALK fusions and activated point mutants","Striated muscle contraction pathway",4722.2,4305.7,6956.8,5573.3,7100.9,6903,0.816495719510451,-0.29248277242829457,0.27714395934380176,0.5572945828923532,0.5308294546236496,0.27504498704043784,3816]
["P68133","Actin, alpha skeletal muscle [OS=Homo sapiens]",40,18,1223,3,377,42,5.39,3506.87,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ACTA1","ENSG00000143632","","Striated Muscle Contraction","Myometrial relaxation and contraction pathways; Fas ligand pathway and stress induction of heat shock proteins; Physico-chemical features and toxicity-associated pathways; Striated muscle contraction pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; IL-18 signaling pathway; Malignant pleural mesothelioma",41139.7,44785.6,38828.6,36132.3,36751.4,30290.6,1.209156737675952,0.2740012669289798,0.0556426925526405,1.2545918626400767,0.25691246990982275,0.5902148156184598,1583]
["P69905","Hemoglobin subunit alpha [OS=Homo sapiens]",22,3,75,3,142,15.2,8.68,198.38,"other metabolic processes;stress response;transport;other biological processes","non-structural extracellular;cytosol;translational apparatus;other cell component","other molecular function","HBA1; HBA2","ENSG00000188536; ENSG00000206172","African trypanosomiasis; Malaria","Heme signaling; Scavenging of heme from plasma; Cytoprotection by HMOX1; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide","Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Effects of nitric oxide",9486.9,9068.3,9231.3,7865.2,8607.6,9512.5,1.0693161133410043,0.09668840846796409,0.2890568539223741,0.5390167284671173,0.5393710863718746,0.2681123381310102,3917]
["P78345","Ribonuclease P protein subunit p38 [OS=Homo sapiens]",18,4,6,4,283,31.8,9.92,14.17,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RPP38","ENSG00000152464","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus","Integrated breast cancer pathway; Sphingolipid metabolism in senescence",311.4,321.2,328.1,354.4,394.1,646.7,0.688575114678899,-0.5383140524896834,0.18925137320903396,0.7229609605732409,0.4483754576287939,0.3483581670585284,3085]
["P78356","Phosphatidylinositol 5-phosphate 4-kinase type-2 beta [OS=Homo sapiens]",31,11,34,6,416,47.3,7.33,83,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle","kinase activity;other molecular function","PIP4K2B","ENSG00000276293; ENSG00000277292","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system; Regulation of actin cytoskeleton","Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs in the nucleus","Regulation of actin cytoskeleton",1412.4,1427.3,1435.5,1416.7,1369,1797.6,0.932777692928676,-0.1003948075131762,0.49154766549130186,0.3084343621530387,0.6624971209802555,0.1788160047045208,5423]
["P78410-1","Butyrophilin subfamily 3 member A2 [OS=Homo sapiens]",25,6,11,4,334,36.4,5.33,34.54,"signal transduction;other biological processes","plasma membrane;other membranes","signal transduction activity or receptor binding","BTN3A2","ENSG00000186470","","Butyrophilin (BTN) family interactions","",1121.4,1048.9,1038.2,1023.1,1030.7,2349.8,0.7286084112998455,-0.4567844447551584,0.41815454196770524,0.3786631815748782,0.6174326358064561,0.20941041862447393,4950]
["P80297","metallothionein-1X [OS=Homo sapiens]",20,1,1,1,61,6.1,7.96,2.54,"stress response;other biological processes","nucleus;other cell component","other molecular function","MT1X","ENSG00000187193","Mineral absorption","Metallothioneins bind metals","Copper homeostasis; Zinc homeostasis; Oxidative stress response",48.8,44.7,50.3,37.4,43.8,45.9,1.1313926042486233,0.17809964543433915,0.14256168849809953,0.84599716950063,0.39634210012651555,0.4019297937230198,2629]
["P80303","Nucleobindin-2 [OS=Homo sapiens]",8,3,4,3,420,50.2,5.12,11.01,"","","","","","","","",271.6,307.3,584.8,549.9,675.7,1040.7,0.5134801217844063,-0.9616196679216084,0.10697824380170573,0.9707045359370641,0.3478220569157772,0.45864288095011463,2248]
["P82673-1","28S ribosomal protein S35, mitochondrial [OS=Homo sapiens]",30,9,16,8,323,36.8,8.24,39.55,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPS35","ENSG00000061794","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1559.4,1523.4,1985.1,2088.7,2153.6,1718,0.8502759928191534,-0.23399689029284543,0.2129511228080591,0.6717200657190947,0.47294431984324037,0.3251899861294953,3291]
["P82912-1","28S ribosomal protein S11, mitochondrial [OS=Homo sapiens]",34,4,10,4,194,20.6,10.81,31.36,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes","other membranes;cytosol;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPS11","ENSG00000181991","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",874.3,968.3,1090.7,924.6,883.1,973.7,1.0546127849284535,0.07671339153365997,0.4972839493505665,0.30339555810333546,0.6662966793406583,0.17633235114372317,5455]
["P82987-1","ADAMTS-like protein 3 [OS=Homo sapiens]",1,1,1,1,1691,188.6,7.83,0,"cell organization and biogenesis;protein metabolism","non-structural extracellular;extracellular matrix;other cell component","other molecular function","ADAMTSL3","ENSG00000156218","","Defective B3GALTL causes PpS; O-glycosylation of TSR domain-containing proteins","",29.4,25.4,33.7,24.2,24.2,2.5,1.738703339882122,0.7980117988946646,0.1753575733517541,0.7560754730453749,0.43271050088722846,0.3638025653465916,2962]
["P84077","ADP-ribosylation factor 1 [OS=Homo sapiens]",73,11,196,5,181,20.7,6.8,662.51,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","ARF1","ENSG00000143761","Phospholipase D signaling pathway; Endocytosis; Vibrio cholerae infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Legionellosis","COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; COPI-mediated anterograde transport; Synthesis of PIPs at the plasma membrane; Intra-Golgi traffic; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis; trans-Golgi Network Vesicle Budding; Synthesis of PIPs at the Golgi membrane; Nef Mediated CD4 Down-regulation","Cell migration and invasion through p75NTR; Neural crest cell migration during development; Neural crest cell migration in cancer; Insulin signaling",16529.8,16410.7,16036,14093.5,15437.3,15953.2,1.0767852431624307,0.10673054373633034,0.11240990202551256,0.9491954307097832,0.3564442403056275,0.4480083985514771,2305]
["P84095","Rho-related GTP-binding protein RhoG [OS=Homo sapiens]",60,8,48,7,191,21.3,8.12,179.23,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","other molecular function","RHOG","ENSG00000177105","Bacterial invasion of epithelial cells; Salmonella infection; Yersinia infection","Neutrophil degranulation; RHOG GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; RHO GTPases activate KTN1","Brain-derived neurotrophic factor (BDNF) signaling pathway",3598.8,3807.3,3566,2939.9,2946.6,2889.9,1.2501823070963038,0.3221384903801039,7.0635114271112159E-4,3.150979347914022,0.03687657501482563,1.433249421708287,140]
["P98155-1","very low-density lipoprotein receptor [OS=Homo sapiens]",1,1,1,1,873,96,4.79,1.97,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component","other molecular function","VLDLR","ENSG00000147852","Spinocerebellar ataxia; Lipid and atherosclerosis","VLDLR internalisation and degradation; Reelin signalling pathway; VLDL clearance","Familial hyperlipidemia type 3",32.4,21.8,20.7,30.1,24,29.4,0.8970059880239521,-0.15681047890266345,0.5322538456275463,{"$f":"-LOG10(AA2499)","v":0.27388119202437106},0.6882950031301727,{"$f":"-LOG10(AC2499)","v":0.1622253833169191},5652]
["P99999","cytochrome c [OS=Homo sapiens]",41,4,26,4,105,11.7,9.57,56.92,"other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus","other molecular function","CYCS","ENSG00000172115","Oxidative phosphorylation; Metabolic pathways; Platinum drug resistance; p53 signaling pathway; Apoptosis; Apoptosis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Legionellosis; Toxoplasmosis; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Colorectal cancer; Small cell lung cancer; Viral myocarditis; Lipid and atherosclerosis","Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Respiratory electron transport; TP53 Regulates Metabolic Genes; Detoxification of Reactive Oxygen Species; Formation of apoptosome; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity; Release of apoptotic factors from the mitochondria; Pyroptosis","miRNA regulation of DNA damage response; Alzheimer's disease and miRNA effects; AGE/RAGE pathway; Parkinson's disease pathway; Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; VEGFA-VEGFR2 signaling pathway; Oxidative damage response; NO/cGMP/PKG mediated neuroprotection; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Acute viral myocarditis; Nonalcoholic fatty liver disease; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Malignant pleural mesothelioma; Complement system in neuronal development and plasticity; Alzheimer's disease; DNA damage response",2560.8,2524.8,2689.5,2887.8,2643.8,1661.9,1.0808507680544936,0.11216734541308031,0.6350359011033395,0.197201721620879,0.765036657518429,0.11631775468095427,6067]
["Q00013-1","55 kDa erythrocyte membrane protein [OS=Homo sapiens]",25,11,13,11,466,52.3,7.37,29.49,"other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","kinase activity","MPP1","ENSG00000130830; ENSGGOG00000001049; ENSPPAG00000040588; ENSPTRG00000022450; ENSPTRG00000051407","","Sensory processing of sound by outer hair cells of the cochlea","MECP2 and associated Rett syndrome",1229.8,1312.9,1253.1,1307,1263,1872.7,0.8543903482116731,-0.22703274545764157,0.3370562673774663,0.4722975929810763,0.5751912814060007,0.24018770549367274,4283]
["Q00577","Transcriptional activator protein Pur-alpha [OS=Homo sapiens]",43,9,24,9,322,34.9,6.44,87.56,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","PURA","ENSG00000185129","","","Exercise-induced circadian regulation",3123.3,2903.1,3194.3,3082,3126.9,1980.6,1.1259173331705232,0.17110090610102402,0.4223663490436254,0.3743106903957219,0.6186524338997712,0.20855327413513883,4990]
["Q00653-1","Nuclear factor NF-kappa-B p100 subunit [OS=Homo sapiens]",34,22,60,21,900,96.7,6.25,196.7,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NFKB2","ENSG00000077150","MAPK signaling pathway; NF-kappa B signaling pathway; Osteoclast differentiation; C-type lectin receptor signaling pathway; Legionellosis; Human T-cell leukemia virus 1 infection; Epstein-Barr virus infection; Pathways in cancer; Viral carcinogenesis; Breast cancer","Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; PKMTs methylate histone lysines; RIP-mediated NFkB activation via ZBP1; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; Interleukin-1 processing; DEx/H-box helicases activate type I IFN and inflammatory cytokines production ; SUMOylation of immune response proteins","Regulation of toll-like receptor signaling pathway; Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Neural crest differentiation; Thymic stromal lymphopoietin (TSLP) signaling pathway; TNF-alpha signaling pathway; Ebstein-Barr virus LMP1 signaling; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Toll-like receptor signaling related to MyD88; ApoE and miR-146 in inflammation and atherosclerosis; Ebola virus pathway in host; Breast cancer pathway; Acute viral myocarditis; miRNAs involvement in the immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Interactions between immune cells and microRNAs in tumor microenvironment; Head and neck squamous cell carcinoma; IL-18 signaling pathway; FGF23 signaling in hypophosphatemic rickets and related disorders; Mitochondrial immune response to SARS-CoV-2; Neuroinflammation and glutamatergic signaling; Network map of SARS-CoV-2 signaling pathway; Inclusion body myositis; Sudden infant death syndrome (SIDS) susceptibility pathways",6607.5,7038.9,6697.9,8031,7792.6,7409.6,0.8756563882719556,-0.19156323440580417,0.0125858567060957,1.9001172171385246,0.13179086914735455,0.8801146778777126,698]
["Q00987-1","E3 ubiquitin-protein ligase Mdm2 [OS=Homo sapiens]",14,6,9,6,491,55.2,4.69,20.89,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","MDM2","ENSG00000135679","Endocrine resistance; Platinum drug resistance; FoxO signaling pathway; Cell cycle; p53 signaling pathway; Ubiquitin mediated proteolysis; Endocytosis; PI3K-Akt signaling pathway; Cellular senescence; C-type lectin receptor signaling pathway; Thyroid hormone signaling pathway; Shigellosis; Human cytomegalovirus infection; Human papillomavirus infection; Epstein-Barr virus infection; Pathways in cancer; Transcriptional misregulation in cancer; Viral carcinogenesis; Proteoglycans in cancer; MicroRNAs in cancer; Glioma; Prostate cancer; Melanoma; Bladder cancer; Chronic myeloid leukemia","Ub-specific processing proteases; Oxidative Stress Induced Senescence; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of RUNX3 expression and activity; SUMOylation of ubiquitinylation proteins; SUMOylation of transcription factors; Regulation of TP53 Degradation; Regulation of TP53 Activity through Phosphorylation; Oncogene Induced Senescence; Regulation of TP53 Activity through Methylation; AKT phosphorylates targets in the cytosol; Stabilization of p53; Trafficking of AMPA receptors","Androgen receptor signaling pathway; miRNA regulation of DNA damage response; TP53 network; Cell cycle; Glioblastoma signaling pathways; Retinoblastoma gene in cancer; Apoptosis; Bladder cancer; Copper homeostasis; VEGFA-VEGFR2 signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of p53 pathway in prostate cancer; PI3K-Akt signaling pathway; Genotoxicity pathway; G1 to S cell cycle control; Male infertility; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; Malignant pleural mesothelioma; Senescence and autophagy in cancer; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)",779.8,742.3,694.3,530,545.9,1817.5,0.7660192161470932,-0.3845475112327081,0.6253234516229076,0.2038952835863477,0.75770708022411,0.12049865456409235,6032]
["Q01167","Forkhead box protein K2 [OS=Homo sapiens]",8,5,12,4,660,69,9.54,25.47,"other metabolic processes;stress response;other biological processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","FOXK2","ENSG00000141568","","UCH proteinases","",534,576.2,558.7,582.5,557,677.6,0.9184414726762425,-0.12274030579901649,0.2706867521505285,0.5675329987869826,0.5246484941575743,0.2801315693086299,3771]
["Q01518-1","adenylyl cyclase-associated protein 1 [OS=Homo sapiens]",53,23,275,1,475,51.9,8.06,908.04,"cell organization and biogenesis;transport;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","CAP1","ENSG00000131236","","Neutrophil degranulation; Platelet degranulation ; Role of ABL in ROBO-SLIT signaling","Angiopoietin-like protein 8 regulatory pathway; Insulin signaling; Complement system in neuronal development and plasticity",571.6,656.7,566.8,597.1,577.2,848.1,0.8876087816455697,-0.17200415383526607,0.45615996208000836,0.3408828361369561,0.6387113338779274,0.19469537725524527,5220]
["Q01581","hydroxymethylglutaryl-CoA synthase, cytoplasmic [OS=Homo sapiens]",20,9,22,9,520,57.3,5.41,67.63,"other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","other molecular function","HMGCS1","ENSG00000112972","Valine, leucine and isoleucine degradation; Butanoate metabolism; Terpenoid backbone biosynthesis; Metabolic pathways; PPAR signaling pathway","PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Endochondral ossification; Endochondral ossification with skeletal dysplasias",2648.3,2620.2,2636.5,5696.1,5759.4,3125.9,0.5421290136749558,-0.8832918757060272,0.062285162074227234,1.205615401122399,0.2684211377361597,0.571183287159121,1696]
["Q01974","Tyrosine-protein kinase transmembrane receptor ROR2 [OS=Homo sapiens]",3,3,3,3,943,104.7,6.55,6.43,"cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;kinase activity;other molecular function","ROR2","ENSG00000169071","Wnt signaling pathway","WNT5A-dependent internalization of FZD2, FZD5 and ROR2","Cardiac progenitor differentiation; Ectoderm differentiation; Wnt signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Malignant pleural mesothelioma",483.3,496.2,566.2,382,433.9,580.4,1.1069970636682662,0.14665139534724383,0.4847005330208852,0.3145265026871811,0.6570245170344307,0.18241842433047153,5392]
["Q02040-1","A-kinase anchor protein 17A [OS=Homo sapiens]",16,12,23,12,695,80.7,9.73,49.25,"RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus","other molecular function","AKAP17A","ENSG00000197976","","","",2459.6,2574.8,2433.5,2736.8,2832,2643.9,0.9093111887686143,-0.13715399005707074,0.023350944450341176,1.6316955493044365,0.17292001315860553,0.7621547400901002,987]
["Q02241-1","Kinesin-like protein KIF23 [OS=Homo sapiens]",27,19,31,19,960,110,8.51,90.01,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KIF23","ENSG00000137807","MicroRNAs in cancer","COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; MHC class II antigen presentation; Mitotic Telophase/Cytokinesis","Malignant pleural mesothelioma",2349.3,2300.7,2448,1867.2,1940.4,1736.3,1.2803261242085895,0.35651133979624816,0.002165952093952355,2.664351153233424,0.0604234498270907,1.2187944826691968,262]
["Q02383","Semenogelin-2 [OS=Homo sapiens]",1,1,2,1,582,65.4,9.07,4.54,"stress response;other biological processes","non-structural extracellular","other molecular function","SEMG2","ENSG00000124157","","","Genotoxicity pathway",354.9,384.8,456.2,377.9,362.2,513.4,0.9540486637415239,-0.06786523835469596,0.7516221474827567,0.12400043135512441,0.8409010065745398,0.075255127660964,6533]
["Q02556","Interferon regulatory factor 8 [OS=Homo sapiens]",2,1,2,1,426,48.3,6.77,2.2,"other metabolic processes;stress response;transport;developmental processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","IRF8","ENSG00000140968","Pertussis","Interferon gamma signaling; Interferon alpha/beta signaling","Vitamin D receptor pathway; Development of pulmonary dendritic cells and macrophage subsets; Type II interferon signaling (IFNG)",71,112.4,60.8,80.7,51.5,4163.5,0.056847545219638244,-4.136758137507113,0.37877415431309003,0.42161966277899227,0.5954958687619649,0.2251212470781064,4649]
["Q03001-7","dystonin [OS=Homo sapiens]",12,83,135,79,7570,860.1,5.25,375.37,"cell adhesion;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes","extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","DST","ENSG00000151914","","RND1 GTPase cycle; RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; Type I hemidesmosome assembly","",11262.9,11422,11398.9,13901.4,13249.9,12874.6,0.8515436255024872,-0.23184765226026982,2.8661565645295844E-3,2.542700089844431,0.06757657525853784,1.1702038217947308,310]
["Q03252","Lamin-B2 [OS=Homo sapiens]",64,48,309,41,620,69.9,5.59,891.24,"","other membranes;cytoskeleton;nucleus","other molecular function","LMNB2","ENSG00000176619","Apoptosis","","Gastric cancer network 2; Fas ligand pathway and stress induction of heat shock proteins; IL-18 signaling pathway; Familial partial lipodystrophy (FPLD); Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome",35977.4,37439.4,37514.2,37355.7,34099.4,36810.3,1.024620977708483,0.03509033440870991,0.4735848229081977,0.32460222400649835,0.6493024705751298,0.18755294464748937,5331]
["Q03468","DNA excision repair protein ERCC-6 [OS=Homo sapiens]",3,4,4,4,1493,168.3,8.09,11.65,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","ERCC6","ENSG00000225830","Nucleotide excision repair","Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; B-WICH complex positively regulates rRNA expression; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression","Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum",382.4,397,360.3,445.7,415.7,379,0.9188165108029668,-0.12215131322644383,0.20243872625099252,0.6937064039452772,0.46094225861947175,0.3363534744661763,3210]
["Q04656-1","copper-transporting ATPase 1 [OS=Homo sapiens]",8,8,15,8,1500,163.3,6.24,40.93,"","","","","","","","",1118.4,1154.8,1140.3,1178.6,1128.2,1399.4,0.9210242296692028,-0.11868898464697535,0.30977159978067687,0.5089584013731976,0.5578025678238402,0.25351949080651,4059]
["Q04695","Keratin, type I cytoskeletal 17 [OS=Homo sapiens]",27,12,31,3,432,48.1,5.02,86.77,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","other molecular function","KRT17","ENSG00000128422","Estrogen signaling pathway; Staphylococcus aureus infection","Formation of the cornified envelope","",310.7,313.1,349.4,287.3,360.6,1769.8,0.4025313314306986,-1.3128270136713194,0.3748599247052951,0.4261309863846684,0.5935552837242205,0.22653882464837044,4616]
["Q05469-1","hormone-sensitive lipase [OS=Homo sapiens]",9,7,14,7,1076,116.5,6.7,42.9,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","LIPE","ENSG00000079435","cAMP signaling pathway; AMPK signaling pathway; Apelin signaling pathway; Thermogenesis; Insulin signaling pathway; Regulation of lipolysis in adipocytes; Aldosterone synthesis and secretion","Triglyceride catabolism","AMP-activated protein kinase (AMPK) signaling; Fatty acid beta-oxidation; Adipogenesis; Triacylglyceride synthesis; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Lipid metabolism pathway; Thermogenesis; Insulin signaling; Orexin receptor pathway; Familial partial lipodystrophy (FPLD)",701,729.5,692.7,682.7,678.1,921.7,0.930208105147864,-0.10437458438875363,0.5488974798071795,0.2605087632215694,0.7018704828395163,0.1537430214565291,5716]
["Q05519","serine/arginine-rich splicing factor 11 [OS=Homo sapiens]",18,10,38,10,484,53.5,10.52,76.07,"RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","SRSF11","ENSG00000116754","","mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript","",4473.7,4480.8,4349.1,4569.3,4557.2,3760.7,1.0323111304239867,0.04587785319389604,0.6354322728617212,0.19693073164008243,0.7650097977839434,0.1163330026290584,6071]
["Q06124-2","Isoform 2 of Tyrosine-protein phosphatase non-receptor type 11 [OS=Homo sapiens]",39,21,47,21,593,68,7.3,127.47,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","PTPN11","ENSG00000179295; ENSMMUG00000013253; ENSRROG00000031729","Ras signaling pathway; Phospholipase D signaling pathway; Axon guidance; C-type lectin receptor signaling pathway; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; Leukocyte transendothelial migration; Neurotrophin signaling pathway; Adipocytokine signaling pathway; Insulin resistance; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Herpes simplex virus 1 infection; Proteoglycans in cancer; Chemical carcinogenesis; Renal cell carcinoma; Chronic myeloid leukemia; PD-L1 expression and PD-1 checkpoint pathway in cancer","PIP3 activates AKT signaling; GPVI-mediated activation cascade; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by SCF-KIT; RET signaling; Platelet sensitization by LDL; CTLA4 inhibitory signaling; FLT3 Signaling; Interleukin-3, Interleukin-5 and GM-CSF signaling; PD-1 signaling; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; Signal regulatory protein family interactions; PI3K Cascade; Downstream signal transduction; Tie2 Signaling; Interleukin-6 signaling; Signaling by Leptin; Regulation of IFNG signaling; Regulation of IFNA signaling; Signaling by CSF3 (G-CSF); GAB1 signalosome; PI-3K cascade:FGFR1; FRS-mediated FGFR1 signaling; PI-3K cascade:FGFR2; FRS-mediated FGFR2 signaling; FRS-mediated FGFR3 signaling; PI-3K cascade:FGFR3; FRS-mediated FGFR4 signaling; PI-3K cascade:FGFR4; Activated NTRK2 signals through FRS2 and FRS3; Spry regulation of FGF signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; Prolactin receptor signaling; Interleukin-20 family signaling; Netrin mediated repulsion signals; Interleukin-37 signaling; Signaling by FLT3 ITD and TKD mutants; PECAM1 interactions; MET activates PTPN11; STAT5 activation downstream of FLT3 ITD mutants; Regulation of RUNX1 Expression and Activity; STAT5 Activation","IL-5 signaling pathway; Heart development; IL-1 signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Pilocytic astrocytoma; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL-6 signaling pathway; Hepatitis C and hepatocellular carcinoma; VEGFA-VEGFR2 signaling pathway; Embryonic stem cell pluripotency pathways; IL-4 signaling pathway; Ras signaling; EGF/EGFR signaling pathway; Fragile X syndrome; Cancer immunotherapy by CTLA4 blockade; Cancer immunotherapy by PD-1 blockade; Gastrin signaling pathway; Netrin-UNC5B signaling pathway; Insulin signaling; IL-2 signaling pathway; Angiotensin II receptor type 1 pathway; Kallmann syndrome; Interferon type I signaling pathways; Type II interferon signaling (IFNG); T-cell receptor (TCR) signaling pathway",5820.4,6125.2,6201.7,5829.4,5349.3,5228,{"$f":"AVERAGE(S2626:U2626)/AVERAGE(V2626:X2626)","v":1.1060908043665085},{"$f":"LOG(Y2626,2)","v":0.14546982827765534},{"$f":"TTEST(V2626:X2626,S2626:U2626,2,2)","v":0.055902980695915976},1.2525650353107654,{"$f":"AA2626*7309/AE2626","v":0.2573015654322732},0.5895575715178698,1588]
["Q06481","Amyloid-like protein 2 [OS=Homo sapiens]",4,4,4,4,763,86.9,4.79,8.09,"signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","APLP2","ENSG00000084234","","Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","Splicing factor NOVA regulated synaptic proteins",600.9,607,558.4,455,450.7,610.3,1.1651055408970978,0.2204606470960974,0.2017316187111057,0.6952260266481065,0.4603360603057982,0.3369250034279552,3203]
["Q07020","60S ribosomal protein L18 [OS=Homo sapiens]",46,8,48,8,188,21.6,11.72,150.29,"protein metabolism;other metabolic processes","cytosol;ER/Golgi;translational apparatus;nucleus","nucleic acid binding activity;other molecular function","RPL18","ENSG00000063177","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis","Cytoplasmic ribosomal proteins",6317,5307.7,5805.5,6706,7625.6,6459.6,0.8383450690676824,-0.2543839047055751,0.07119040082579826,1.1475785618327368,0.291665156746502,0.5351154499888681,1784]
["Q07157","Tight junction protein ZO-1 [OS=Homo sapiens]",18,28,46,26,1748,195.3,6.7,137.15,"cell adhesion;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","TJP1","ENSG00000104067; ENSG00000277401","Adherens junction; Tight junction; Gap junction; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection","RUNX1 regulates expression of components of tight junctions; Signaling by Hippo; Apoptotic cleavage of cell adhesion  proteins; Regulation of gap junction activity","Epithelial to mesenchymal transition in colorectal cancer; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; Disruption of postsynaptic signaling by CNV; 1q21.1 copy number variation syndrome",4405.6,4427.9,4267.8,5215.9,4976.2,7524.5,0.7394929049591907,-0.43539178938762335,0.13174724758978978,0.8802584491253027,0.3824228088299339,0.4174562130131735,2518]
["Q07866-6","Isoform N of Kinesin light chain 1 [OS=Homo sapiens]",38,25,77,21,628,71,6.67,227.5,"","","","KLC1","","","","",9421.7,9397.2,9352.5,9975.5,10145.3,6531.6,1.056992991250319,0.07996581047468185,0.6893343782152442,0.16157006200070112,0.7992298493615515,0.09732830459822701,6304]
["Q07889","Son of sevenless homolog 1 [OS=Homo sapiens]",7,8,10,8,1333,152.4,6.84,23.92,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","SOS1","ENSG00000115904","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; MAPK signaling pathway; ErbB signaling pathway; Ras signaling pathway; Chemokine signaling pathway; FoxO signaling pathway; Phospholipase D signaling pathway; mTOR signaling pathway; PI3K-Akt signaling pathway; Focal adhesion; Gap junction; JAK-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; B cell receptor signaling pathway; Fc epsilon RI signaling pathway; Thermogenesis; Neurotrophin signaling pathway; Regulation of actin cytoskeleton; Insulin signaling pathway; GnRH signaling pathway; Estrogen signaling pathway; Prolactin signaling pathway; Relaxin signaling pathway; Growth hormone synthesis, secretion and action; Alcoholism; Hepatitis C; Hepatitis B; Human cytomegalovirus infection; Human papillomavirus infection; Pathways in cancer; Proteoglycans in cancer; MicroRNAs in cancer; Chemical carcinogenesis; Chemical carcinogenesis; Colorectal cancer; Renal cell carcinoma; Endometrial cancer; Glioma; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Non-small cell lung cancer; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Choline metabolism in cancer","RAC1 GTPase cycle; Role of LAT2/NTAL/LAB on calcium mobilization; RET signaling; FLT3 Signaling; Downstream signal transduction; Tie2 Signaling; FRS-mediated FGFR1 signaling; FRS-mediated FGFR2 signaling; FRS-mediated FGFR3 signaling; FRS-mediated FGFR4 signaling; Activated NTRK2 signals through FRS2 and FRS3; Signaling by FLT3 ITD and TKD mutants; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; NRAGE signals death through JNK; G alpha (12/13) signalling events; Interleukin receptor SHC signaling; RAF/MAP kinase cascade; DAP12 signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; Regulation of KIT signaling; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; GRB2 events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; GRB2 events in EGFR signaling; SHC1 events in EGFR signaling; NCAM signaling for neurite out-growth; Signaling by FGFR1 in disease; SHC-mediated cascade:FGFR1; SHC-mediated cascade:FGFR2; Signaling by FGFR2 in disease; SHC-mediated cascade:FGFR3; SHC-mediated cascade:FGFR4; Signaling by FGFR3 point mutants in cancer; Activation of RAC1; Erythropoietin activates RAS; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; SOS-mediated signalling; Signalling to RAS; SHC-related events triggered by IGF1R; Signaling by FGFR4 in disease; MET activates RAS signaling; Signaling by FGFR3 fusions in cancer; Activated NTRK2 signals through RAS; Activated NTRK3 signals through RAS; Constitutive Signaling by Overexpressed ERBB2; Signaling by FLT3 fusion proteins; Signal attenuation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Interleukin-15 signaling","IL-5 signaling pathway; Integrin-mediated cell adhesion; Leptin signaling pathway; Prolactin signaling pathway; Pilocytic astrocytoma; B cell receptor signaling pathway; TNF-alpha signaling pathway; Oncostatin M signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL-6 signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Acute viral myocarditis; Thermogenesis; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Malignant pleural mesothelioma; Regulation of actin cytoskeleton; EPO receptor signaling; ErbB signaling pathway; T-cell receptor (TCR) signaling pathway; DNA damage response (only ATM dependent)",803.2,837.4,802.4,809.9,795.5,843.6,0.9975500204164965,-3.5389102967217775E-3,0.9183970592548951,0.036969515572644024,0.9474331836406533,0.02345140827215025,7085]
["Q08378","Golgin subfamily A member 3 [OS=Homo sapiens]",27,31,49,31,1498,167.3,5.44,179.93,"other biological processes","other membranes;cytosol;ER/Golgi;nucleus","","GOLGA3","ENSG00000090615","","RND2 GTPase cycle","",3792.3,3740.3,3782.8,4138.6,4304.2,5305.8,0.8230219804198249,-0.2809971337189287,0.09037911264582875,1.0439319269449796,0.32429108214450775,0.4890649940611707,2037]
["Q08752","peptidyl-prolyl cis-trans isomerase D [OS=Homo sapiens]",59,23,87,22,370,40.7,7.21,264.19,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","other molecular function","PPID","ENSG00000171497","Necroptosis; Cellular senescence; Alzheimer disease; Pathways of neurodegeneration; Shigellosis","ESR-mediated signaling","Alzheimer's disease and miRNA effects; NO/cGMP/PKG mediated neuroprotection; Alzheimer's disease",11797.2,11681.9,11444.3,12414,12837.2,11379.6,0.9533889513742531,-0.068863188474881,0.2702725485503556,0.5681980631378888,0.5245411729565983,0.2802204169345618,3766]
["Q08AD1","Calmodulin-regulated spectrin-associated protein 2 [OS=Homo sapiens]",8,9,11,9,1489,168,6.8,30.42,"cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi","cytoskeletal activity;other molecular function","CAMSAP2","ENSG00000118200","","","",882.3,956.3,896.2,1041.6,1035.4,2342.4,0.6188170339865141,-0.6924151849303504,0.2665142688866508,0.5742795343565656,0.5215402386325384,0.28271217862401016,3735]
["Q09327","Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase [OS=Homo sapiens]",8,3,3,3,533,61.3,8.28,8.11,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi","other molecular function","MGAT3","ENSG00000128268","N-Glycan biosynthesis; Metabolic pathways","Reactions specific to the hybrid N-glycan synthesis pathway","",161.6,117.8,146.8,235.5,286.9,183.4,0.6038537829413432,-0.7277288369970207,0.045694386346362706,1.340137150664227,0.233716074041683,0.6313114175712243,1429]
["Q0P6H9","Transmembrane protein 62 [OS=Homo sapiens]",11,5,7,5,643,73.1,9.26,26.35,"","other membranes","other molecular function","TMEM62","ENSG00000137842","","","",456,494.7,457,481.6,412.6,618.7,{"$f":"AVERAGE(S2690:U2690)/AVERAGE(V2690:X2690)","v":0.9304646705003635},{"$f":"LOG(Y2690,2)","v":-0.10397672231552378},{"$f":"TTEST(V2690:X2690,S2690:U2690,2,2)","v":0.6012883558194302},0.22091720635295894,{"$f":"AA2690*7309/AE2690","v":0.7393702208418935},0.13113804522150488,5944]
["Q0VDG4-1","secernin-3 [OS=Homo sapiens]",26,9,16,9,424,48.5,5.55,46.04,"protein metabolism","","other molecular function","SCRN3","ENSG00000144306","","","",1491.8,1437.3,1452.8,1498.9,1465.6,1103.5,1.0771632251720746,0.10723688154753867,0.458421849531184,0.3387346909868184,0.639672641890688,0.19404222319205883,5238]
["Q11201","CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 [OS=Homo sapiens]",15,4,7,4,340,39.1,9.09,28.5,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","ST3GAL1","ENSG00000008513","Mucin type O-glycan biosynthesis; Glycosaminoglycan biosynthesis; Glycosphingolipid biosynthesis; Glycosphingolipid biosynthesis; Metabolic pathways","Maturation of spike protein; Sialic acid metabolism; Keratan sulfate biosynthesis; Maturation of protein 3a; Maturation of protein 3a; Termination of O-glycan biosynthesis","Ganglio sphingolipid metabolism; Globo sphingolipid metabolism",562.9,561.4,555.9,760,842.4,894.8,0.6728335736024347,-0.5716783987157442,0.002274751025868897,2.6430661304391463,0.060679398715604994,1.2169587313755612,274]
["Q12765","Secernin-1 [OS=Homo sapiens]",3,1,1,1,414,46.4,4.75,2.14,"protein metabolism;transport","other membranes;nucleus;other cell component","other molecular function","SCRN1","ENSG00000136193","","","",47.6,46.1,37.3,49.1,27.6,96.7,0.7554786620530565,-0.40453708679702244,0.5316337778894394,0.2743874335138021,0.6882237482454682,0.16227034544072969,5646]
["Q12792-2","Twinfilin-1 [OS=Homo sapiens]",40,12,33,9,350,40.3,6.96,94.03,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","TWF1","ENSG00000151239","","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHOBTB2 GTPase cycle","",2159.6,2284.2,2154.4,2219.2,2014.8,2623.6,0.9621733551096592,-0.05563124660359123,0.6626155616410787,0.1787383688532606,0.7835394175755774,0.10593915056111308,6181]
["Q12824-1","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 [OS=Homo sapiens]",37,10,52,10,385,44.1,6.23,155.01,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","LOC101347788; LOC111142756; Smarcb1; SMARCB1","ENSCAFG00000014105; ENSCATG00000029590; ENSCCAG00000036123; ENSCHIG00000019816; ENSCSAG00000011285; ENSDLEG00000015913; ENSECAG00000007797; ENSG00000099956; ENSG00000275837; ENSHGLG00000019077; ENSMFAG00000040790; ENSMLUG00000004975; ENSMMUG00000009098; ENSMNEG00000033936; ENSMUSG00000000902; ENSPANG00000026464; ENSPPAG00000028391; ENSRBIG00000027964; ENSRFEG00010017090; ENSRROG00000030710; ENSSBOG00000031674; ENSSSCG00000010070; ENSSSCG00070020965; ENSSSUG00005014167; ENSSTOG00000012408; ENSTSYG00000008262; ENSUAMG00000010813","Thermogenesis; Hepatocellular carcinoma","RMTs methylate histone arginines; RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines","TNF-alpha NF-kB signaling pathway; Tumor suppressor activity of SMARCB1; Thermogenesis; Modulators of TCR signaling and T cell activation",2771.9,2632,2661.7,2911.4,2810.9,2680.2,0.9599047902409996,-0.05903677807336251,0.22974607579331507,0.6387518978999097,0.48985241189420653,0.30993474926709724,3428]
["Q12851","Mitogen-activated protein kinase kinase kinase kinase 2 [OS=Homo sapiens]",13,8,11,8,820,91.5,6.34,30,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi","kinase activity;other molecular function","MAP4K2","ENSG00000168067","MAPK signaling pathway","","TNF-alpha signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Insulin signaling; Malignant pleural mesothelioma",624.7,630.6,615,629.5,640.7,731.2,0.934495852902968,-0.09773983328139961,0.2501270761588591,0.6018392935157764,0.5091001948329438,0.2931967367578765,3591]
["Q12893","Transmembrane protein 115 [OS=Homo sapiens]",15,4,8,4,351,38.2,8.16,28.67,"transport;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","TMEM115","ENSG00000126062","","COPI-mediated anterograde transport","",454.7,444.6,436.6,405.9,346.6,449.4,1.1114901406106996,0.1524951511043213,0.2138257229609393,0.669940050913872,0.47373513462306915,0.32446440457524295,3299]
["Q12907","Vesicular integral-membrane protein VIP36 [OS=Homo sapiens]",42,13,93,13,356,40.2,6.95,303.48,"cell organization and biogenesis;transport;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","LMAN2","ENSG00000169223","Protein processing in endoplasmic reticulum","COPII-mediated vesicle transport; Cargo concentration in the ER","",14099.3,14379.8,14022.9,12068.5,12275,12963.1,1.1392622216980375,0.1880998474877033,4.0199858973808825E-3,2.395775470472845,0.0775252689286461,1.1105567185569443,379]
["Q12931","heat shock protein 75 kDa, mitochondrial [OS=Homo sapiens]",50,30,194,29,704,80.1,8.21,663.74,"other biological processes","other membranes;mitochondrion;nucleus","signal transduction activity or receptor binding;other molecular function","TRAP1","ENSG00000126602","Parkinson disease; Pathways of neurodegeneration","Respiratory electron transport","TNF-alpha signaling pathway; TGF-beta signaling pathway",16775.9,17204.9,16739.5,15818.5,15338.3,15506.9,1.0869326692911192,0.12026257450655954,0.002747622703771065,2.5610429036794464,0.0667188516340954,1.1757514373893168,301]
["Q12979","active breakpoint cluster region-related protein [OS=Homo sapiens]",17,15,38,15,859,97.5,6.55,106.76,"signal transduction;other biological processes","cytosol;other cell component","enzyme regulator activity","ABR","ENSG00000159842; ENSG00000276016; ENSG00000278741","","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC3 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOC GTPase cycle; RAC2 GTPase cycle; RHOB GTPase cycle","",4876.7,4900.4,4939.3,4838.1,4608.3,3004.6,1.1819452252831095,0.24116317845666677,0.2607426204562885,0.5837879741400316,0.517871688292123,0.2857778309295762,3680]
["Q12982","BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 [OS=Homo sapiens]",13,5,6,5,314,36,4.81,16.43,"other metabolic processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","BNIP2","ENSG00000140299","","Myogenesis","Acute viral myocarditis",841.9,777.6,804.5,896.2,992.8,623.9,0.9646225476541048,-0.05196356199201463,0.804417365899016,0.09451856235089574,0.8764887488604514,0.05725365440097093,6708]
["Q13033-2","Isoform Alpha of Striatin-3 [OS=Homo sapiens]",11,6,9,1,713,77.7,5.26,23.04,"","","","STRN3","","","","",33.1,35.8,39.8,29.7,41.2,39.5,0.9846014492753622,-0.022388231750860067,0.8962025505659009,0.04759382443199111,0.9326989095950691,0.030258530964304916,7023]
["Q13085-1","Acetyl-CoA carboxylase 1 [OS=Homo sapiens]",18,34,70,29,2346,265.4,6.37,209.21,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","ACACA","ENSG00000275176; ENSG00000278540","Fatty acid biosynthesis; Pyruvate metabolism; Propanoate metabolism; Metabolic pathways; Fatty acid metabolism; AMPK signaling pathway; Insulin signaling pathway; Glucagon signaling pathway; Alcoholic liver disease","Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency; ChREBP activates metabolic gene expression; Carnitine metabolism; Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis","AMP-activated protein kinase (AMPK) signaling; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; Corticotropin-releasing hormone signaling pathway; Mesodermal commitment pathway; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin and adiponectin; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Mitochondrial fatty acid synthesis pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; 7q11.23 copy number variation syndrome",6446.2,6608.9,6645.2,6580.9,6338.7,7368.5,0.9710273510087194,-0.0424161621585356,0.5697748787154088,0.24429670264968975,0.715301372128293,0.14551094186850883,5822]
["Q13107-1","Ubiquitin carboxyl-terminal hydrolase 4 [OS=Homo sapiens]",25,18,30,17,963,108.5,5.71,84.23,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","USP4","ENSG00000114316","","Ub-specific processing proteases; Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway; TNFR1-induced proapoptotic signaling","",2278.5,2284.6,2220.8,2510.5,2349.7,2009,0.9875822512082922,-0.018027186235619604,0.8581737766698343,0.06642476039480409,0.9098334977777515,0.04103807758275996,6894]
["Q13144","Translation initiation factor eIF-2B subunit epsilon [OS=Homo sapiens]",25,14,54,14,721,80.3,5.08,172.66,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;translational apparatus;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","EIF2B5","ENSG00000145191","Herpes simplex virus 1 infection","Recycling of eIF2:GDP","Translation factors; MicroRNAs in cardiomyocyte hypertrophy",5035.7,4942.7,4949.3,4725.6,4582.1,6262.7,0.958722961516724,-0.06081410945384907,0.7111790501229391,0.14802104527464405,0.8137144141121733,0.08952799085711637,6388]
["Q13164-1","Mitogen-activated protein kinase 7 [OS=Homo sapiens]",8,4,10,4,816,88.3,5.88,27.2,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","MAPK7","ENSG00000166484","MAPK signaling pathway; Gap junction; IL-17 signaling pathway; Neurotrophin signaling pathway; GnRH signaling pathway; Oxytocin signaling pathway; MicroRNAs in cancer; Fluid shear stress and atherosclerosis","Senescence-Associated Secretory Phenotype (SASP); Gastrin-CREB signalling pathway via PKC and MAPK; ERKs are inactivated; RET signaling; Signalling to ERK5","MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Brain-derived neurotrophic factor (BDNF) signaling pathway; S1P receptor signal transduction; Cardiac hypertrophic response; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Osteoblast differentiation and related diseases; Insulin signaling; Malignant pleural mesothelioma",272.1,282.7,256.3,256.1,273.9,513.5,0.7772879731672255,-0.36347890102853525,0.4052647749596339,0.39226114287927555,0.6104864468631418,0.21432397318983798,4852]
["Q13188","serine/threonine-protein kinase 3 [OS=Homo sapiens]",22,10,38,6,491,56.3,5.24,113.73,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","STK3","ENSG00000104375","MAPK signaling pathway; Hippo signaling pathway; Hippo signaling pathway","Signaling by Hippo","MAPK signaling pathway; Transcription co-factors SKI and SKIL protein partners; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Overview of leukocyte-intrinsic Hippo pathway functions; Malignant pleural mesothelioma",1109.4,1076.5,1072.1,957.6,1044.5,679.1,1.2151275548261973,0.2811077649061241,0.15781437677005059,0.8018534354263995,0.41417065702416506,0.3828206730521743,2785]
["Q13232","Nucleoside diphosphate kinase 3 [OS=Homo sapiens]",37,6,24,6,169,19,7.84,62.61,"other metabolic processes;other biological processes","cytosol","kinase activity;other molecular function","NME3","ENSG00000103024","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors","Interconversion of nucleotide di- and triphosphates","Pyrimidine metabolism",3288.6,3273.3,3166.8,3073,3146.3,3209.7,1.0317849188673243,0.0451422645375808,0.1435958184696813,0.842858206625643,0.39680220687897944,0.40142592111287473,2645]
["Q13243-1","Serine/arginine-rich splicing factor 5 [OS=Homo sapiens]",30,9,51,8,272,31.2,11.59,160.37,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","SFRS5; SRSF5","ENSCANG00000030560; ENSCCAG00000029002; ENSCJAG00000014884; ENSCSAG00000013041; ENSG00000100650; ENSGGOG00000016462; ENSMFAG00000002393; ENSMMUG00000022407; ENSMNEG00000030872; ENSNLEG00000001615; ENSPPAG00000029921; ENSPPYG00000005945; ENSPTRG00000006488; ENSRBIG00000013003; ENSRROG00000043407; ENSSBOG00000030784","Spliceosome; Herpes simplex virus 1 infection","mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination","mRNA processing; mRNA Processing",5734.8,5809.7,5357,5863.6,6091,6165.1,0.9327693063350937,-0.1004077788261219,0.071745490429416,1.1442053913628814,0.2923008860360098,0.5341698681869816,1794]
["Q13303-2","Isoform 2 of Voltage-gated potassium channel subunit beta-2 [OS=Homo sapiens]",48,13,60,13,353,39.3,8.62,152.58,"","","","KCNAB2","","","","",6385.3,6298.5,6455,5938.5,5925.7,5065.1,1.1305133703106445,0.17697805459877114,0.06552808533982292,1.1835725214761468,0.27684669118425764,0.5577606627209691,1730]
["Q13325","Interferon-induced protein with tetratricopeptide repeats 5 [OS=Homo sapiens]",21,9,16,9,482,55.8,7.4,47.35,"stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","nucleic acid binding activity","IFIT5","ENSG00000152778","","Interferon alpha/beta signaling","",1417.8,1461.5,1418,1588.6,1413.3,981.1,1.0789103690685415,0.10957501730839322,0.5939460821251917,0.2262529780799598,0.7346677803779025,0.13390900617565338,5909]
["Q13395","Probable methyltransferase TARBP1 [OS=Homo sapiens]",2,3,3,3,1621,181.6,7.05,7.9,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","TARBP1","ENSG00000059588","","","",266,262.1,234.9,285.2,281.5,464.3,0.7400581959262852,-0.43428937053357786,0.2176191493506656,0.6623028916419968,0.47865734655552655,0.31997527103673495,3323]
["Q13423","NAD(P) transhydrogenase, mitochondrial [OS=Homo sapiens]",42,39,277,39,1086,113.8,8.09,854.59,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","NNT","ENSG00000112992","Nicotinate and nicotinamide metabolism; Metabolic pathways","Citric acid cycle (TCA cycle)","",41420,41146,40462.5,34477,35727.9,32138,1.2021205183749926,0.2655815404300722,3.1947240700584455E-3,2.4955666461209045,0.0705445263687528,1.1515366780126504,331]
["Q13433-1","Zinc transporter ZIP6 [OS=Homo sapiens]",3,2,3,2,755,85,6.95,8.51,"transport;other biological processes","plasma membrane;other membranes;ER/Golgi","transporter activity","SLC39A6","ENSG00000141424","Alzheimer disease; Parkinson disease","Zinc influx into cells by the SLC39 gene family","Nuclear receptors meta-pathway; NRF2 pathway; Zinc homeostasis",589.4,567.5,533,508.5,501.1,549.7,1.08375553132816,0.11603935676830192,0.12286284856920128,0.9105794198031716,0.37061682220069836,0.4310748720567048,2423]
["Q13439-1","Golgin subfamily A member 4 [OS=Homo sapiens]",23,44,60,42,2230,261,5.39,181.85,"cell organization and biogenesis;transport;developmental processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","GOLGA4","ENSG00000144674","","Retrograde transport at the Trans-Golgi-Network; Signaling by membrane-tethered fusions of PDGFRA or PDGFRB","",4472.7,4600.5,4432.8,5062.7,4901,5392,0.879543101258816,-0.1851738174189632,0.01575750959715691,1.8025124196939533,0.14578688309572133,0.8362815491004219,790]
["Q13464","Rho-associated protein kinase 1 [OS=Homo sapiens]",36,47,75,41,1354,158.1,5.9,189.39,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function","ROCK1","ENSG00000067900","cGMP-PKG signaling pathway; cAMP signaling pathway; Chemokine signaling pathway; Sphingolipid signaling pathway; Vascular smooth muscle contraction; TGF-beta signaling pathway; Axon guidance; Focal adhesion; Tight junction; Platelet activation; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Pathogenic Escherichia coli infection; Shigellosis; Yersinia infection; Human cytomegalovirus infection; Pathways in cancer; Proteoglycans in cancer; MicroRNAs in cancer","Neutrophil degranulation; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHOB GTPase cycle; Sema4D induced cell migration and growth-cone collapse; RND3 GTPase cycle; RHOBTB1 GTPase cycle; EPHB-mediated forward signaling; Potential therapeutics for SARS; VEGFA-VEGFR2 Pathway; Apoptotic cleavage of cellular proteins; EPHA-mediated growth cone collapse; RHO GTPases Activate ROCKs; RHOH GTPase cycle","Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Microtubule cytoskeleton regulation; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Focal adhesion; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Chemokine signaling pathway; EGF/EGFR signaling pathway; Gastrin signaling pathway; mBDNF and proBDNF regulation of GABA neurotransmission; MAP3K1 role in promoting and blocking gonadal determination; Airway smooth muscle cell contraction; RAS and bradykinin pathways in COVID-19; Regulation of actin cytoskeleton; G13 signaling pathway",8105.2,8769.5,8625.4,8906.5,8483,7989,1.004791457335934,6.896103705757755E-3,0.9090315175195434,0.041421058859959704,0.9410922608428247,0.0263677980277905,7060]
["Q13480-1","GRB2-associated-binding protein 1 [OS=Homo sapiens]",26,13,23,13,694,76.6,5.96,75.05,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;other cell component","","GAB1","ENSG00000109458","EGFR tyrosine kinase inhibitor resistance; ErbB signaling pathway; Ras signaling pathway; Phospholipase D signaling pathway; Neurotrophin signaling pathway; Bacterial invasion of epithelial cells; Proteoglycans in cancer; Renal cell carcinoma; Hepatocellular carcinoma; Gastric cancer","Signaling by ERBB2 KD Mutants; Signaling by FGFR1 in disease; Signaling by FGFR2 in disease; Signaling by FGFR3 point mutants in cancer; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FGFR4 in disease; Signaling by FGFR3 fusions in cancer; RET signaling; PIP3 activates AKT signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Constitutive Signaling by Aberrant PI3K in Cancer; MET activates RAP1 and RAC1; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); PI3K Cascade; PI3K events in ERBB2 signaling; GAB1 signalosome; PI-3K cascade:FGFR1; PI-3K cascade:FGFR2; PI-3K cascade:FGFR3; PI-3K cascade:FGFR4; MET activates PI3K/AKT signaling; MET activates PTPN11; MET receptor recycling; Activated NTRK2 signals through PI3K","Glioblastoma signaling pathways; B cell receptor signaling pathway; Alpha 6 beta 4 signaling pathway; Hepatocyte growth factor receptor signaling; IL-6 signaling pathway; BDNF-TrkB signaling; VEGFA-VEGFR2 signaling pathway; Embryonic stem cell pluripotency pathways; Ras signaling; EGF/EGFR signaling pathway; Fragile X syndrome; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; ErbB signaling pathway",2368.8,2327.3,2326.7,2221.9,2218,2830.7,0.9659175308777818,-0.05002807650189539,0.7063525770512766,0.1509784660220785,0.8107303683523526,0.09112355886771814,6368]
["Q13510","Acid ceramidase [OS=Homo sapiens]",39,14,67,14,395,44.6,7.62,179.54,"other metabolic processes;developmental processes;other biological processes","non-structural extracellular;nucleus;other cytoplasmic organelle;other cell component","other molecular function","ASAH1","ENSG00000104763","Sphingolipid metabolism; Metabolic pathways; Sphingolipid signaling pathway; Lysosome","Neutrophil degranulation; Glycosphingolipid metabolism","Sphingolipid pathway; S1P receptor signal transduction; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway; Sphingolipid metabolism in senescence",7400.4,7404.2,7236,6810.9,7121.3,6359.6,1.0861825959254474,0.11926665203042427,0.06284006255699016,1.2017633912937111,0.2701753042523771,0.5683543507880121,1700]
["Q13555-8","Isoform 8 of Calcium/calmodulin-dependent protein kinase type II subunit gamma [OS=Homo sapiens]",27,11,24,9,556,62.1,7.42,70.38,"protein metabolism;other metabolic processes;other biological processes","other cell component","kinase activity;other molecular function","CAMK2G; LOC111145432","ENSCATG00000041481; ENSECAG00000000031; ENSFCAG00000018407; ENSG00000148660; ENSLCNG00005022562; ENSMPUG00000003376; ENSPANG00000022457; ENSPTRG00000002643","ErbB signaling pathway; Calcium signaling pathway; cAMP signaling pathway; HIF-1 signaling pathway; Oocyte meiosis; Necroptosis; Adrenergic signaling in cardiomyocytes; Wnt signaling pathway; Axon guidance; Circadian entrainment; Long-term potentiation; Neurotrophin signaling pathway; Cholinergic synapse; Dopaminergic synapse; Olfactory transduction; Inflammatory mediator regulation of TRP channels; Insulin secretion; GnRH signaling pathway; Melanogenesis; Oxytocin signaling pathway; Glucagon signaling pathway; Aldosterone synthesis and secretion; Cushing syndrome; Gastric acid secretion; Parkinson disease; Pathways of neurodegeneration; Amphetamine addiction; Tuberculosis; Pathways in cancer; Proteoglycans in cancer; Glioma; Diabetic cardiomyopathy; Lipid and atherosclerosis","","Energy metabolism; Myometrial relaxation and contraction pathways; NO/cGMP/PKG mediated neuroprotection; Splicing factor NOVA regulated synaptic proteins; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Disruption of postsynaptic signaling by CNV; Neuroinflammation and glutamatergic signaling; Calcium regulation in cardiac cells; ErbB signaling pathway; Calcium regulation in cardiac cells",2244.7,2176.9,2226.2,1871.5,1771.1,1723.9,1.2387589676698034,0.30889550146094563,8.812753369975728E-4,3.0548883836912664,0.040767350874147214,1.3896875087617158,158]
["Q13564-1","NEDD8-activating enzyme E1 regulatory subunit [OS=Homo sapiens]",54,17,64,17,534,60.2,5.4,215.51,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","NAE1","ENSG00000159593","Alzheimer disease","Neddylation","Alzheimer's disease and miRNA effects; Hijack of ubiquitination by SARS-CoV-2; Alzheimer's disease",5925.8,5967,5731.3,5694.2,5645.9,6678.4,0.9781113855204372,-0.03192932890436262,0.721899240737881,0.14152341495840345,0.8194380417072795,0.0864838781665547,6439]
["Q13576-1","Ras GTPase-activating-like protein IQGAP2 [OS=Homo sapiens]",47,62,224,61,1575,180.5,5.64,738.75,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","IQGAP2","ENSG00000145703","Regulation of actin cytoskeleton","CDC42 GTPase cycle; RAC1 GTPase cycle; Neutrophil degranulation; RHOG GTPase cycle; RHO GTPases activate IQGAPs","Ciliary landscape; G13 signaling pathway",24025.9,23984.3,23976.8,21279.9,21419.5,18646.7,1.173456829366496,0.23076476712353713,0.01707131279896646,1.7677330799734776,0.15179346137183194,0.818746935629555,822]
["Q13614-1","Myotubularin-related protein 2 [OS=Homo sapiens]",8,3,3,3,643,73.3,7.4,11.38,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MTMR2","ENSG00000087053; ENSGGOG00000010339; ENSPPAG00000042525; ENSPTRG00000004195","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; Synthesis of PIPs at the ER membrane","Intracellular trafficking proteins involved in CMT neuropathy",95.6,90.9,91.8,86.8,87,158,0.8387582881253767,-0.25367297762425595,0.49438028651533494,0.3059388551285883,0.664966049713026,0.1772005273264873,5434]
["Q13617-1","Cullin-2 [OS=Homo sapiens]",37,25,81,25,745,86.9,6.92,223.45,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction","cytosol;nucleus;other cell component","other molecular function","CUL2","ENSCANG00000032700; ENSCATG00000031722; ENSCCAG00000022671; ENSG00000108094; ENSMFAG00000044478; ENSMMUG00000002469; ENSMNEG00000040111; ENSPANG00000022742; ENSPPYG00000019905","HIF-1 signaling pathway; Ubiquitin mediated proteolysis; Pathways in cancer; Renal cell carcinoma","Antigen processing: Ubiquitination & Proteasome degradation; Regulation of expression of SLITs and ROBOs; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Neddylation","Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2",9573,10327.9,10146.5,9142.9,8258.9,7409.4,1.211041787579803,0.2762486467779305,0.033697086379501334,1.472407648802503,0.2038841095594166,0.6906166212036432,1208]
["Q13636","ras-related protein rab-31 [OS=Homo sapiens]",8,1,1,1,194,21.6,7.06,4.1,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","RAB31","ENSG00000168461","Endocytosis","Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation","",29.1,26.2,23.2,22.4,22.6,33.1,1.005121638924456,0.007370105637010201,0.9745145759725561,0.011211660684781669,0.9847541871676223,0.006672163897924829,7233]
["Q13642-1","Isoform 1 of Four and a half LIM domains protein 1 [OS=Homo sapiens]",58,14,55,14,280,31.9,8.32,169.98,"","","","FHL1","","","","",11156.2,11200.2,10908.6,10559.4,10081.4,9983.4,1.086232456684583,0.11933287682468349,0.011627330272474727,1.9345199912931732,0.12760383928155825,0.8941362585795012,666]
["Q13813","Spectrin alpha chain, non-erythrocytic 1 [OS=Homo sapiens]",71,168,1089,1,2472,284.4,5.35,3590.42,"cell organization and biogenesis","non-structural extracellular;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SPTAN1","ENSG00000197694","Apoptosis","Neutrophil degranulation; COPI-mediated anterograde transport; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Interaction between L1 and Ankyrins; RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Caspase-mediated cleavage of cytoskeletal proteins","Fas ligand pathway and stress induction of heat shock proteins",826.1,837.6,823.3,902.9,931,549.1,1.043642467477969,0.061627556026635645,0.7919833590099932,0.10128394362017809,0.8679871601445553,0.06148669915485821,6669]
["Q13868","Exosome complex component Rrp4 [OS=Homo sapiens]",25,6,17,6,293,32.8,7.5,62.26,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","EXOSC2","ENSG00000130713","RNA degradation","ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; Major pathway of rRNA processing in the nucleolus and cytosol; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease","Ciliary landscape",1224.8,1494.2,1514.9,1268,1095.9,764.6,1.3533322678599968,0.43651609086143534,0.10272116429014837,0.988340066748731,0.3425132252722146,0.46532265467708955,2192]
["Q13948","Protein CASP [OS=Homo sapiens]",35,22,48,5,678,77.4,5.44,118.09,"transport","other membranes;ER/Golgi;nucleus","","CUX1","ENSG00000257923","","Intra-Golgi traffic","",476.3,456.7,446.6,496.7,533.6,349.8,0.9996377074125063,-5.2277242333399862E-4,0.9977996710061642,9.5664359209773333E-4,0.998346036329097,7.1890197844036061E-4,7305]
["Q13951-2","Isoform 2 of Core-binding factor subunit beta [OS=Homo sapiens]",29,5,16,5,187,22,5.58,50.61,"","","","CBFB","","","","",1347,1169.8,1448.7,1534.1,1666.9,1018.2,0.9398701175578309,-0.0894666930990781,0.7128516848506867,0.14700081958888778,0.8139717176337555,0.08939068490070523,6401]
["Q14061","cytochrome C oxidase copper chaperone [OS=Homo sapiens]",32,2,7,2,63,6.9,7.24,22.8,"cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes","mitochondrion;other cell component","other molecular function","COX17","ENSG00000138495","Oxidative phosphorylation; Metabolic pathways; Thermogenesis","Mitochondrial protein import","Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis; IL-18 signaling pathway; Mitochondrial complex IV assembly",654.4,602.4,583.4,544.4,616.7,614.4,1.0364404393128694,0.051637212079841524,0.5352387203956938,0.2714524762456214,0.6903228881898934,0.16094772700314444,5667]
["Q14108-1","Lysosome membrane protein 2 [OS=Homo sapiens]",27,12,78,12,478,54.3,5.14,208.67,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SCARB2","ENSG00000138760","Lysosome","Cargo recognition for clathrin-mediated endocytosis","Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome",10059.3,10075.6,9753.7,8424.2,8813.4,6991.2,1.233598032094037,0.30287236889797925,0.028677040622501333,1.5424656684725646,0.18934100262860185,0.7227553274673145,1107]
["Q14141-1","Septin-6 [OS=Homo sapiens]",47,19,85,9,434,49.7,6.67,271.65,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component","other molecular function","SEPTIN6","ENSCANG00000016430; ENSCATG00000036060; ENSG00000125354; ENSMLEG00000030428; ENSMMUG00000017669; ENSMNEG00000026932; ENSPANG00000000899; ENSPPAG00000040865; ENSRBIG00000044672; ENSRROG00000038667","Bacterial invasion of epithelial cells; Shigellosis","","",12893.5,12758.1,12620.2,13888.8,13526.6,11628.1,0.9802348662389387,-0.028800631617136734,0.7338480868966779,0.13439383361354754,0.8287539658726543,0.0815743803337905,6472]
["Q14147","Probable ATP-dependent RNA helicase DHX34 [OS=Homo sapiens]",9,6,8,6,1143,128,7.56,16.79,"RNA metabolism OR transcription;other metabolic processes;other biological processes","","other molecular function","DHX34","ENSG00000134815","","","",428.9,415.6,446.2,500,514.5,436.4,{"$f":"AVERAGE(S2946:U2946)/AVERAGE(V2946:X2946)","v":0.889585774346957},{"$f":"LOG(Y2946,2)","v":-0.16879437724320245},{"$f":"TTEST(V2946:X2946,S2946:U2946,2,2)","v":0.1050065997078093},0.9787834044861532,{"$f":"AA2946*7309/AE2946","v":0.3452511188773631},0.4618649053011708,2223]
["Q14164","Inhibitor of nuclear factor kappa-B kinase subunit epsilon [OS=Homo sapiens]",6,4,5,3,716,80.4,7.84,15.39,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","IKBKE","ENSG00000263528","Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Alcoholic liver disease; Hepatitis C; Hepatitis B; Measles; Influenza A; Human papillomavirus infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease; Chemical carcinogenesis; Lipid and atherosclerosis","Negative regulators of DDX58/IFIH1 signaling; SUMOylation of immune response proteins; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon; TICAM1-dependent activation of IRF3/IRF7","Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Cardiac hypertrophic response; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor (RLR) pathway; Ebola virus pathway in host; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; STING pathway in Kawasaki-like disease and COVID-19; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Toll-like receptor signaling pathway",359.3,318.3,408.1,353.5,377.3,376.7,0.9803160270880361,-0.028681185236048092,0.8019379047775406,0.09585925846959029,0.8744389297357965,0.058270515979343546,6703]
["Q14197","Peptidyl-tRNA hydrolase ICT1, mitochondrial [OS=Homo sapiens]",8,2,3,2,206,23.6,10.07,7.23,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL58","ENSG00000167862","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",586,475.2,640.9,678.9,597.1,447.5,0.9875834058601682,-0.018025499480354798,0.9359907889450152,0.02872842511877063,0.9588166329921676,0.018264440685463453,7135]
["Q14204","Cytoplasmic dynein 1 heavy chain 1 [OS=Homo sapiens]",44,185,631,185,4646,532.1,6.4,1919.08,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","DYNC1H1","ENSG00000197102","Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection","Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; COPI-mediated anterograde transport; Neutrophil degranulation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; HCMV Early Events; COPI-independent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Aggrephagy","Ciliary landscape; Intraflagellar transport proteins binding to dynein",69656.3,70630.6,71749.2,64816.8,62724.8,66577,1.0923018196092493,0.12737154992946337,0.009212985256234554,2.035599623848785,0.11471500721945206,0.9403797632124264,587]
["Q14247-1","Src substrate cortactin [OS=Homo sapiens]",4,2,2,2,550,61.5,5.4,3.99,"cell adhesion;cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","CTTN","ENSG00000085733; ENSG00000288401","Tight junction; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Proteoglycans in cancer","Clathrin-mediated endocytosis; RHO GTPases activate PAKs","Pathogenic Escherichia coli infection; Hepatitis C and hepatocellular carcinoma",116.2,108.7,103.8,104,124.9,147.4,0.8735051820356098,-0.19511183298757132,0.29056703919325244,0.5367536519387573,0.5406706948735952,0.2670671691696965,3928]
["Q14331","Protein FRG1 [OS=Homo sapiens]",24,6,20,6,258,29.2,9.01,52.02,"RNA metabolism OR transcription;other metabolic processes;developmental processes","cytoskeleton;nucleus","cytoskeletal activity","FRG1","ENSG00000109536; ENSG00000275145; ENSG00000283153; ENSG00000283630","","","",2914.9,2714.2,3048.4,3293.6,3663.9,2507.4,0.9168084184724614,-0.12530780337466657,0.500209773666514,0.30084782678391225,0.6675247828607906,0.17553260582872454,5477]
["Q14376","UDP-glucose 4-epimerase [OS=Homo sapiens]",40,12,41,12,348,38.3,6.73,131.26,"other metabolic processes","cytosol","other molecular function","GALE","ENSG00000117308","Galactose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars","Galactose catabolism; Defective GALE can cause Epimerase-deficiency galactosemia (EDG)","",4089.8,4271,4146,3726.5,3343.9,2820,1.26453935129014,0.3386119330294502,0.031301931384665985,1.5044288648872597,0.19791160596066062,0.7035287370877971,1156]
["Q14498-1","RNA-binding protein 39 [OS=Homo sapiens]",31,13,35,13,530,59.3,10.1,115.7,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","LOC101348913; LOC111141906; LOC112827340; Rbm39; RBM39","ENSAMEG00000009940; ENSANAG00000024610; ENSBIXG00000021585; ENSBIXG00005010311; ENSBMUG00000009739; ENSCAFG00000008327; ENSCCAG00000031689; ENSDLEG00000014321; ENSECAG00000013423; ENSFCAG00000003233; ENSG00000131051; ENSGGOG00000003950; ENSHGLG00000017871; ENSLAFG00000010346; ENSLCNG00005002645; ENSMMUG00000031284; ENSMNEG00000040217; ENSMPUG00000017786; ENSOCUG00000007050; ENSPCOG00000027976; ENSPCTG00005007206; ENSPPAG00000029710; ENSPPYG00000010963; ENSPTRG00000049720; ENSRBIG00000044413; ENSRFEG00010016851; ENSRROG00000037484; ENSSSCG00000007309; ENSSSCG00070008152; ENSSSUG00005008586; ENSTTRG00000017039; ENSUAMG00000010443; ENSUMAG00000004302; ENSVVUG00000001290","","","mRNA Processing; VEGFA-VEGFR2 signaling pathway; mRNA processing; mRNA Processing",5516.9,4802.9,4791.4,5212.6,6166.1,4166.8,0.9720626547875592,-0.040878788424501565,0.8282555308249259,0.08183565535698853,0.8924841036118801,0.04939951053803774,6783]
["Q14554","Protein disulfide-isomerase A5 [OS=Homo sapiens]",40,16,47,16,519,59.6,7.91,140.49,"other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","PDIA5","ENSG00000065485","","XBP1(S) activates chaperone genes","",4410.6,4336.2,4392.5,4043,3801.8,3816.4,1.1267536788666688,0.17217216048063785,3.7310176846574185E-3,2.4281726924410982,0.07596102578596399,1.1194091791354444,359]
["Q14596-1","Next to BRCA1 gene 1 protein [OS=Homo sapiens]",7,4,4,4,966,107.3,5.12,7.5,"other metabolic processes;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","other molecular function","NBR1","ENSG00000188554","Mitophagy","Pexophagy","",255.7,231.4,252.9,229.7,259.2,444.7,0.792630676949443,-0.33527929030367365,0.39462866467405666,0.40381137205485856,0.6037975528789365,0.21910865145423947,4777]
["Q14671-3","Isoform 3 of Pumilio homolog 1 [OS=Homo sapiens]",12,12,15,8,1188,126.6,6.84,37.44,"","","","PUM1","","","","",1153.9,1317.2,1173.2,1799.8,1716.3,1951.3,{"$f":"AVERAGE(S3010:U3010)/AVERAGE(V3010:X3010)","v":0.66655082854739},{"$f":"LOG(Y3010,2)","v":-0.5852132011226238},{"$f":"TTEST(V3010:X3010,S3010:U3010,2,2)","v":2.1099648715259445E-3},2.675724775142799,{"$f":"AA3010*7309/AE3010","v":0.06071548522040602},1.216700529878764,254]
["Q14677-1","Clathrin interactor 1 [OS=Homo sapiens]",31,20,83,20,625,68.2,6.42,237.51,"cell organization and biogenesis;transport","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","CLINT1","ENSG00000113282","","Golgi Associated Vesicle Biogenesis","",9725,9781.3,9797.1,10207.1,10175.5,16984.9,0.7841948217033519,-0.35071597959185036,0.30092200923243906,0.521546047093286,0.551376025439934,0.25855212151915263,3989]
["Q14692","ribosome biogenesis protein BMS1 homolog [OS=Homo sapiens]",16,16,27,16,1282,145.7,6.44,68.05,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","BMS1","ENSG00000165733","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",1741.8,1758.2,1738.9,3833.4,3706.4,4388.9,0.43918448783186764,-1.187100996198296,4.4238975596619156E-4,3.3541949381655303,0.030794540251018042,1.5115262753514955,105]
["Q14764","major vault protein [OS=Homo sapiens]",62,42,250,42,893,99.3,5.48,824.62,"transport;signal transduction;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","MVP","ENSG00000013364","","Neutrophil degranulation","16p11.2 proximal deletion syndrome",29307.8,29517.5,29924.8,28437.7,28053.5,26598.7,1.0681213962226457,0.09507562434332141,0.03273355901669931,1.4850067726546285,0.20138853775509702,0.6959652514158303,1188]
["Q14790-4","Isoform 4 of Caspase-8 [OS=Homo sapiens]",50,20,54,9,496,57.7,5.43,187.15,"","","","CASP8","","","","",5434.1,5477,5272.8,5193.2,5170.8,4414.9,1.0950679685226912,0.13102041759580013,0.1498241297531587,0.8244182362044706,0.40408286507964464,0.3935295651949034,2710]
["Q14849-1","StAR-related lipid transfer protein 3 [OS=Homo sapiens]",13,4,8,4,445,50.5,8.37,16.7,"cell organization and biogenesis;other metabolic processes;transport","other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","STARD3","ENSG00000131748","Cholesterol metabolism","Pregnenolone biosynthesis","",331.4,369.6,339.6,281.3,258.6,314.9,1.2173607861488065,0.2837567993168812,0.036645067801554354,1.4359844704284157,0.21056509478110125,0.6766136198568378,1272]
["Q14966-1","Zinc finger protein 638 [OS=Homo sapiens]",19,29,48,29,1978,220.5,6.38,116.6,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF638","ENSG00000075292","","Transcriptional regulation of white adipocyte differentiation","",3845.2,3774.1,3727.8,4877,5079.3,5580.3,0.7303464078369786,-0.4533471893468314,2.7411716200845867E-3,2.5620637731717535,0.0670074360240744,1.1738769996122103,299]
["Q14999","Cullin-7 [OS=Homo sapiens]",2,3,3,1,1698,191,5.87,8.39,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","CUL7","ENSG00000044090","Ubiquitin mediated proteolysis","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; XBP1(S) activates chaperone genes","",30.4,48.5,43.9,45.8,42.9,94.5,0.6703056768558953,-0.5771089427267644,0.31637873912759124,0.4997927090865253,0.5626307066383368,0.24977656907862156,4110]
["Q15006","ER membrane protein complex subunit 2 [OS=Homo sapiens]",34,8,35,8,297,34.8,6.57,87.91,"cell organization and biogenesis","other membranes;ER/Golgi;other cell component","","EMC2","ENSG00000104412","","","",1990.4,1977.6,2175.5,1963.4,1900.8,1417.7,1.1631231185747553,0.2180038166357943,0.19336379461777042,0.7136248398170573,0.45182096383033377,0.3450336223208947,3128]
["Q15011-3","Isoform 3 of Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein [OS=Homo sapiens]",22,4,10,4,232,26.2,5.77,25.63,"","","","HERPUD1","","","","",760.1,806.7,717.1,1239.3,1190.9,1768.9,0.5439022647710224,-0.878580661790294,0.02689764454338627,1.5702857499826979,0.18546687166755682,0.7317336533634953,1060]
["Q15022","Polycomb protein suz12 [OS=Homo sapiens]",9,5,9,5,739,83,8.81,24.37,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus","enzyme regulator activity;nucleic acid binding activity;other molecular function","SUZ12","ENSG00000178691","","HCMV Early Events; Oxidative Stress Induced Senescence; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PRC2 methylates histones and DNA; Defective pyroptosis; PKMTs methylate histone lysines; SUMOylation of chromatin organization proteins; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6","Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Malignant pleural mesothelioma",1129.1,1216.9,1123.3,1606.7,1532.8,1417.3,0.7613456811797753,-0.3933764515540683,0.00449358383733703,2.3474071512130883,0.08170050812710536,1.0877752424135854,402]
["Q15042-1","Rab3 GTPase-activating protein catalytic subunit [OS=Homo sapiens]",39,31,82,31,981,110.5,5.55,233.69,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","RAB3GAP1","ENSG00000115839","","RAB GEFs exchange GTP for GDP on RABs; COPI-independent Golgi-to-ER retrograde traffic","",7204.9,7472.1,7325,7642.9,7442.1,7011.4,0.9957278108651182,-0.00617666944330678,0.8835668659845102,0.05376057866513444,0.9253460701362352,0.033695815107074006,6979]
["Q15043","Zinc transporter ZIP14 [OS=Homo sapiens]",9,4,5,4,492,54.2,5.33,18.12,"other metabolic processes;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle","transporter activity","SLC39A14","ENSG00000104635","Ferroptosis; Alzheimer disease; Parkinson disease","Zinc influx into cells by the SLC39 gene family","Nuclear receptors meta-pathway; NRF2 pathway; Zinc homeostasis; Ferroptosis",485.5,498.7,454.9,557,597.2,630.6,0.8063088301210218,-0.3105955733214964,0.009849709503249558,2.006576577928392,0.11919126946895864,0.9237555546655513,604]
["Q15056-1","Eukaryotic translation initiation factor 4H [OS=Homo sapiens]",38,8,31,8,248,27.4,7.23,82.22,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;translational apparatus;other cell component","translation activity;nucleic acid binding activity","EIF4H","ENSG00000106682; ENSPTRG00000019287","","L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Ribosomal scanning and start codon recognition","Translation factors; 7q11.23 copy number variation syndrome",3217.7,2997.8,2589.4,3574,2889.1,2917.6,0.9386186531921925,-0.09138896352132375,0.5438605891147501,0.26451241121632246,0.6979942134924861,0.15614817774746864,5695]
["Q15061","WD repeat-containing protein 43 [OS=Homo sapiens]",30,17,45,17,677,74.8,5.57,106.65,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","WDR43","ENSG00000163811","Ribosome biogenesis in eukaryotes","rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol","",4090.8,4000.8,3886.7,4643.9,4496.7,5180.7,0.836397533743445,-0.2577392869786974,0.02246957427967922,1.6484051558736006,0.1705401021912517,0.7681734811141622,963]
["Q15102","Platelet-activating factor acetylhydrolase IB subunit gamma [OS=Homo sapiens]",41,8,32,8,231,25.7,6.84,85.33,"other metabolic processes;developmental processes;other biological processes","cytosol;other cell component","other molecular function","PAFAH1B3","ENSG00000079462","Ether lipid metabolism; Metabolic pathways","COPI-independent Golgi-to-ER retrograde traffic","",3636.3,3592.1,3713.2,3711.7,3616.1,4676.9,0.9114430181512241,-0.1337756306145377,0.3569408990548015,0.4474036867987273,0.5874535084871749,0.2310264980884303,4441]
["Q15126","phosphomevalonate kinase [OS=Homo sapiens]",78,12,44,12,192,22,5.73,115.47,"other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle","kinase activity;other molecular function","PMVK","ENSG00000163344","Terpenoid backbone biosynthesis; Metabolic pathways; Peroxisome","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis","Cholesterol biosynthesis pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways",5520.1,5536.8,5643.2,6193.4,5898.1,4596.7,1.0007130787023166,1.0283884901915287E-3,0.9939532620305421,2.634036648414819E-3,0.9965438123705395,1.5036030824164646E-3,7290]
["Q15154-1","Pericentriolar material 1 protein [OS=Homo sapiens]",31,44,79,44,2024,228.4,5.02,213.04,"","","","","","","","",6163.6,6444.9,6186.7,8225.3,8400.7,8339,0.7528620068095334,-0.40954263946621927,3.8239712584704416E-5,4.417485380604776,0.018632937285440306,1.7297186777764841,15]
["Q15185","Prostaglandin E synthase 3 [OS=Homo sapiens]",56,9,100,9,160,18.7,4.54,330.43,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","PTGES3","ENSG00000110958","Arachidonic acid metabolism; Metabolic pathways; Chemical carcinogenesis","HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Estrogen-dependent gene expression; Potential therapeutics for SARS; HSF1 activation; Aryl hydrocarbon receptor signalling; Synthesis of Prostaglandins (PG) and Thromboxanes (TX); Attenuation phase","Aryl hydrocarbon receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway",15327.7,14102.3,13736.3,15081.2,15758,10466.6,1.0450421006250938,0.06356106397081855,0.7382140784867433,0.1318176766277584,0.8315004930897837,0.08013748890253936,6489]
["Q15291-1","Retinoblastoma-binding protein 5 [OS=Homo sapiens]",36,14,34,14,538,59.1,5.1,104.98,"protein metabolism;other metabolic processes;stress response;other biological processes","nucleus","nucleic acid binding activity;other molecular function","LOC101350636; RBBP5","ENSANAG00000037817; ENSBIXG00000017360; ENSBIXG00005000379; ENSBTAG00000015946; ENSCANG00000035291; ENSCHIG00000014205; ENSCJAG00000017172; ENSCSAG00000014601; ENSG00000117222; ENSGGOG00000014796; ENSLCNG00005015908; ENSMFAG00000038790; ENSMLEG00000013766; ENSMMUG00000018803; ENSMNEG00000044153; ENSNLEG00000014409; ENSPANG00000015342; ENSPPAG00000004153; ENSPPYG00000000310; ENSPTRG00000001894; ENSRBIG00000028065; ENSRFEG00010013463; ENSRROG00000045061; ENSSSCG00070019803; ENSSSUG00005002678; ENSTSYG00000000255","Cushing syndrome","Formation of the beta-catenin:TCF transactivating complex; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Neddylation; PKMTs methylate histone lysines; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Neddylation; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","",2352.2,2426.5,2464.9,2166.4,2120.1,3806.2,0.8950782804255687,-0.15991423391473472,0.6371957622169668,0.19572712121350952,0.7662493955320517,0.11562985507346064,6078]
["Q15293","Reticulocalbin-1 [OS=Homo sapiens]",48,12,47,12,331,38.9,5,138.54,"","ER/Golgi","other molecular function","RCN1","ENSG00000049449","","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation","VEGFA-VEGFR2 signaling pathway",5206.2,4566.7,3713.2,6474.4,3947.3,3689.5,0.9557018538465897,-0.06536747779381018,0.8432942476444214,0.07402086211189395,0.9005899555863641,0.04547290109698365,6844]
["Q15365","Poly(RC)-binding protein 1 [OS=Homo sapiens]",71,18,365,11,356,37.5,7.09,1369.44,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PCBP1","ENSG00000169564","Spliceosome; Ferroptosis","mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA","Ferroptosis",32732.5,32679.2,31406.1,34548,34031,31053.3,0.9717511289009686,-0.0413412163168358,0.46832188183245854,0.32945554980477715,0.6462081620376514,0.18962756085640192,5297]
["Q15369-1","elongin-C [OS=Homo sapiens]",48,4,18,4,112,12.5,4.78,67.62,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","eloc; Eloc; ELOC; eloc.L; LOC101358566; LOC105890220; LOC107550711; LOC107664095; LOC107751353; LOC111156807; LOC113045545; LOC113937395; LOC115195324; Tceb1; TCEB1","ENSACCG00020004765; ENSACUG00000011303; ENSAMEG00000012854; ENSANAG00000026963; ENSBIXG00000018463; ENSBIXG00005018332; ENSBTAG00000050514; ENSCAFG00000008152; ENSCATG00000020385; ENSCATG00000034779; ENSCCAG00000008410; ENSCCAG00000023220; ENSCGRG00001001449; ENSCHIG00000015198; ENSCPOG00000032030; ENSCPRG00005018410; ENSCSAG00000013512; ENSDLEG00000009234; ENSECAG00000000064; ENSEGOG00005000341; ENSELUG00000027740; ENSFCAG00000032823; ENSG00000154582; ENSGAGG00000025908; ENSGALG00000035417; ENSGGOG00000002188; ENSHGLG00000016964; ENSHHUG00000007733; ENSLCNG00005018064; ENSLSDG00000013506; ENSMFAG00000038428; ENSMMDG00005018719; ENSMNEG00000033021; ENSMODG00000006970; ENSMPUG00000010207; ENSMUSG00000079658; ENSOCUG00000032655; ENSOMYG00000017295; ENSOMYG00000030379; ENSPANG00000016947; ENSPCOG00000017567; ENSPCTG00005011391; ENSPMRG00000007569; ENSPPAG00000004063; ENSPPYG00000018678; ENSPSIG00000003701; ENSPTRG00000045560; ENSPTRG00000046987; ENSPTXG00000006319; ENSRBIG00000038767; ENSRFEG00010008700; ENSRNOG00000031730; ENSRROG00000031208; ENSSANG00000000802; ENSSANG00000018252; ENSSBOG00000024839; ENSSFOG00015012880; ENSSFOG00015024826; ENSSGRG00000038413; ENSSGRG00000052876; ENSSHAG00000009970; ENSSHBG00005007386; ENSSRHG00000026121; ENSSRHG00000030142; ENSSSAG00000055027; ENSSSCG00070017636; ENSSSUG00005020214; ENSSTUG00000043851; ENSTMTG00000005512; ENSTSYG00000035894; ENSUAMG00000019951; ENSVURG00010016846; ENSVURG00010021344; ENSXETG00000011828","HIF-1 signaling pathway; Ubiquitin mediated proteolysis; Human immunodeficiency virus 1 infection; Pathways in cancer; Renal cell carcinoma","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Neddylation; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Inactivation of CSF3 (G-CSF) signaling; RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex ; TP53 Regulates Transcription of DNA Repair Genes; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Neddylation; Inactivation of CSF3 (G-CSF) signaling; Neddylation; Antigen processing: Ubiquitination & Proteasome degradation; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Inactivation of CSF3 (G-CSF) signaling; Neddylation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Antigen processing: Ubiquitination & Proteasome degradation; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Inactivation of CSF3 (G-CSF) signaling; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; TP53 Regulates Transcription of DNA Repair Genes; RNA Polymerase II Pre-transcription Events; RNA Polymerase II Transcription Elongation; Inactivation of CSF3 (G-CSF) signaling; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Inactivation of CSF3 (G-CSF) signaling; RNA Polymerase II Pre-transcription Events; Neddylation; Antigen processing: Ubiquitination & Proteasome degradation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA Polymerase II Transcription Elongation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Dual hijack model of Vif in HIV infection; VEGFA-VEGFR2 signaling pathway; Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2",1241.9,1225.9,1299.4,1690.6,1498.7,1803.2,0.75457185778668,-0.40626979991916956,0.011190166156650928,1.9511634648227771,0.12563582863127745,0.9008864915069961,651]
["Q15393-1","Splicing factor 3B subunit 3 [OS=Homo sapiens]",41,40,162,40,1217,135.5,5.26,514.36,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","Sf3b3; SF3B3","ENSANAG00000028001; ENSBIXG00000000514; ENSBTAG00000010627; ENSCATG00000036562; ENSCCAG00000017736; ENSCJAG00000014773; ENSG00000189091; ENSGGOG00000003246; ENSHGLG00000010135; ENSMFAG00000045487; ENSMMUG00000017812; ENSMNEG00000033385; ENSPANG00000024075; ENSPPAG00000026807; ENSPTRG00000008308; ENSRBIG00000021904; ENSRROG00000045703; ENSSBOG00000029156; ENSSTOG00000007065; ENSTSYG00000007910","Spliceosome","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","mRNA Processing; mRNA processing; mRNA Processing",17297.2,17450.6,18462.4,17615.3,17328.4,16420.1,1.0359474960964727,0.050950886189793175,0.2966065980327024,0.5278191922917153,0.5463451675960236,0.2625328938898833,3968]
["Q15435","Protein phosphatase 1 regulatory subunit 7 [OS=Homo sapiens]",44,13,38,13,360,41.5,4.91,122.15,"other biological processes","other cell component","enzyme regulator activity","PPP1R7","ENSG00000115685","","","",3973.3,4138,3875.5,3770.2,3464.7,2813.1,1.192953821656051,0.2545381984755343,0.0916475172924535,1.037879295467634,0.3256449702919508,0.48725562527838484,2057]
["Q15438-1","Cytohesin-1 [OS=Homo sapiens]",32,13,35,9,398,46.4,5.54,109.11,"transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cell component","enzyme regulator activity;other molecular function","CYTH1","ENSCATG00000038229; ENSG00000108669; ENSMFAG00000037544; ENSMMUG00000013313; ENSPANG00000019854; ENSPTRG00000009717","Phospholipase D signaling pathway; Endocytosis; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection","Intra-Golgi traffic","",2474.2,2533.3,2474.2,2761.8,2910.7,4420.9,0.7412467553054471,-0.4319742103922772,0.17602539326431246,0.7544246767365641,0.4339189205291264,0.3625914125528726,2965]
["Q15542","Transcription initiation factor TFIID subunit 5 [OS=Homo sapiens]",16,8,24,8,800,86.8,5.64,63.3,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","TAF5","ENSG00000148835","Basal transcription factors","RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Regulation of TP53 Activity through Phosphorylation","Eukaryotic transcription initiation",1097.9,1158.9,1220.9,1224.8,1114.7,790.2,1.111192766079816,0.15210911244603054,0.4392492250180475,0.35728899607212666,0.6287647053773813,0.20151184465638522,5106]
["Q15633","RISC-loading complex subunit TARBP2 [OS=Homo sapiens]",2,1,1,1,366,39,6.54,2.9,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TARBP2","ENSG00000139546","","MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis","Fragile X syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies",62,80.2,71.3,105.2,99.5,154.4,0.594541910331384,-0.7501495831568054,0.05602295408810774,1.2516339945781618,0.25736754961029507,0.5894462123407704,1591]
["Q15637-5","Isoform 5 of Splicing factor 1 [OS=Homo sapiens]",24,12,53,12,673,71.7,9.58,169.22,"","","","SF1","","","","",5794.8,5289.9,5577.7,6633.8,7174.9,6158.3,0.8344969199178646,-0.2610213701975385,0.02836548342189104,1.5472098105244272,0.18847574393691055,0.7247445337986793,1100]
["Q15654-1","thyroid receptor-interacting protein 6 [OS=Homo sapiens]",3,1,1,1,476,50.3,7.37,2.8,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","TRIP6","ENSG00000087077","NOD-like receptor signaling pathway","","",21.3,25,22.5,20,19.7,23.4,1.0903328050713152,0.12476855971954877,0.30361784555201965,0.5176727057772187,0.5532642316478962,0.2570674058748926,4011]
["Q15696","U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 [OS=Homo sapiens]",10,4,6,4,482,58,9.72,17.05,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","ZRSR2","ENSG00000169249","","mRNA Splicing - Minor Pathway","",331.3,283.9,278.6,292.7,330.3,269.7,1.0012322168701693,0.001776618802719604,0.9887040703029073,0.004933677934023682,0.994144731028195,2.5503849072193606E-3,7269]
["Q15771","Ras-related protein Rab-30 [OS=Homo sapiens]",55,11,24,9,203,23,4.97,71.5,"cell organization and biogenesis;signal transduction","other membranes;ER/Golgi;other cell component","other molecular function","RAB30","ENSG00000137502","","Intra-Golgi traffic; RAB geranylgeranylation","",2391,2405.5,2481.3,2138.6,2119.3,2121,1.1409177130853283,0.1901947432438702,4.7362008321452572E-4,3.3245698902287137,0.030907939180490788,1.5099299510149224,112]
["Q15811-8","Isoform 8 of Intersectin-1 [OS=Homo sapiens]",7,11,19,1,1716,194.7,7.77,55.22,"","","","ITSN1","","","","",1663.4,1695.8,1624.1,1830.6,1785,1324.4,1.0087651821862347,0.012590386613305736,0.9336946802371497,0.02979511559630754,0.9572695213709254,0.01896576842532434,7129]
["Q15843","NEDD8 [OS=Homo sapiens]",36,4,24,4,81,9.1,8.43,57.78,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","NEDD8","ENSG00000129559; ENSG00000285246","","Cargo recognition for clathrin-mediated endocytosis; UCH proteinases; Neddylation; Iron uptake and transport; TGF-beta receptor signaling activates SMADs","EGF/EGFR signaling pathway",3012.1,2927.7,3150.7,3109.4,3023.6,4198.4,0.879890431112918,-0.1846042124235423,0.3416547383472825,0.46641255174852897,0.5771098873538912,0.23874148506328036,4327]
["Q15904","V-type proton ATPase subunit S1 [OS=Homo sapiens]",9,3,5,3,470,52,6.14,14.3,"transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","ATP6AP1","ENSG00000071553","Oxidative phosphorylation; Metabolic pathways; Lysosome; Phagosome; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Tuberculosis; Hepatitis B; Human papillomavirus infection; Rheumatoid arthritis","Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport; RHOA GTPase cycle","Hepatitis B infection; Oxidative phosphorylation",655.5,749.5,780.4,529.8,496.7,329.2,1.6120085564652946,0.6888594016433532,0.01891934361237273,1.7230939350837762,0.15821679915655867,0.8007474058342061,874]
["Q16254","Transcription factor E2F4 [OS=Homo sapiens]",11,4,4,4,413,43.9,4.75,14.49,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","E2F4","ENSG00000205250","Cell cycle; Cellular senescence; TGF-beta signaling pathway","Cyclin D associated events in G1; G1/S-Specific Transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest","Cell cycle; Adipogenesis; TGF-beta signaling pathway",419.4,395.6,397.5,512.9,538.4,462.5,0.8009644602985865,-0.32018986484824163,0.013044895290492018,1.8845594025694352,0.13353661019356605,0.8743996524616368,714]
["Q16401","26S proteasome non-ATPase regulatory subunit 5 [OS=Homo sapiens]",46,16,61,16,504,56.2,5.48,181.89,"cell organization and biogenesis","cytosol;nucleus;other cell component","","PSMD5","ENSG00000095261","","Degradation of DVL; Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Parkin-ubiquitin proteasomal system pathway",7279.5,7125.3,7095.8,6357.4,6393.7,5341.4,1.1883708719082493,0.24898514890214965,0.031375406589687856,1.503410637510469,0.19803354642834933,0.7032612350179135,1158]
["Q16540","39S ribosomal protein L23, mitochondrial [OS=Homo sapiens]",13,1,1,1,153,17.8,9.69,2.29,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus","nucleic acid binding activity;other molecular function","MRPL23","ENSG00000214026; ENSG00000288141","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",28.7,26.3,26.9,21.5,27,58.3,0.7668539325842697,-0.38297629004654526,0.5098067361804133,0.2925944304072476,0.6750321439751161,0.1706755462524735,5520]
["Q16563","Synaptophysin-like protein 1 [OS=Homo sapiens]",10,2,2,2,259,28.5,8.43,6.69,"cell-cell signaling","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","SYPL1","ENSG00000008282","","","",351.2,312.2,304.3,307,370.5,360.5,0.9322736030828517,-0.10117467661382507,0.3924659206221637,0.4061980487997859,0.6031399103926397,0.21958193286246686,4756]
["Q16629","serine/arginine-rich splicing factor 7 [OS=Homo sapiens]",37,11,91,10,238,27.4,11.82,225.6,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","nucleus;other cell component","other molecular function","SRSF7","ENSG00000115875","Spliceosome; Amyotrophic lateral sclerosis; Herpes simplex virus 1 infection","Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Minor Pathway","mRNA processing",12061.8,11102.4,11831,11498.8,12349.7,12064.5,0.9744437947261436,-0.03734912070059906,0.46833800481547916,0.329440598545183,0.6461084328418907,0.1896945906224223,5298]
["Q16690","Dual specificity protein phosphatase 5 [OS=Homo sapiens]",6,1,1,1,384,42,8.35,3.41,"protein metabolism;other metabolic processes;developmental processes;signal transduction","nucleus;other cell component","other molecular function","DUSP5","ENSG00000138166","MAPK signaling pathway","Negative regulation of MAPK pathway; RAF-independent MAPK1/3 activation","Endoderm differentiation; VEGFA-VEGFR2 signaling pathway",19.6,21.3,20.9,34.1,31.9,62.5,0.48093385214007783,-1.0560896161768658,0.08732910677874646,1.0588409818780022,0.3191442207229289,0.4960130156580104,2000]
["Q16763","ubiquitin-conjugating enzyme E2 S [OS=Homo sapiens]",18,4,6,4,222,23.8,8.38,19.55,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","UBE2S","ENSG00000108106","Ubiquitin mediated proteolysis","APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; APC-Cdc20 mediated degradation of Nek2A; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; APC/C:Cdc20 mediated degradation of Securin; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","",488.7,456,591.8,533.5,584,2408.6,0.43575054592893,-1.198425623058567,0.343737012444503,0.4637737019769293,0.578621332095088,0.23760555921135762,4342]
["Q16774-1","guanylate kinase [OS=Homo sapiens]",47,8,28,8,197,21.7,6.55,84.33,"other metabolic processes;transport","cytosol;other cell component","kinase activity;other molecular function","GUK1","ENSG00000143774","Purine metabolism; Metabolic pathways","Interconversion of nucleotide di- and triphosphates; Abacavir metabolism","",3429.1,2909.1,3756.4,3237.1,3625.1,1651.9,1.185633243678134,0.24565780469397086,0.4644010397475463,0.3331068165904051,0.6435925672193432,0.19138898016384767,5274]
["Q16854","Deoxyguanosine kinase, mitochondrial [OS=Homo sapiens]",3,1,3,1,277,32,8.66,8.22,"protein metabolism;other metabolic processes;other biological processes","cytosol;mitochondrion;other cell component","kinase activity;other molecular function","DGUOK","ENSG00000114956","Purine metabolism; Metabolic pathways","Purine salvage","",162.5,168.4,201.6,151.5,140.2,163.8,1.1690450054884742,0.22533047131114992,0.13956947249793422,0.8552095629128269,0.39295580681332865,0.40565628915718555,2596]
["Q16864-1","V-type proton ATPase subunit F [OS=Homo sapiens]",33,3,7,3,119,13.4,5.52,19.7,"transport","other membranes;cytosol;other cytoplasmic organelle","transporter activity;other molecular function","ATP6V1F","ENSCATG00000033101; ENSG00000128524; ENSGGOG00000023527; ENSMLEG00000037581; ENSPPAG00000012238; ENSPPAG00000027671; ENSPTRG00000019672; ENSPTRG00000040903","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis","ROS and RNS production in phagocytes; Amino acids regulate mTORC1; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Proximal tubule transport",750.6,765.5,1136.7,995.1,1154.3,1079.6,0.8215546608857233,-0.28357152900559257,0.22619752527402384,0.6455121508062969,0.4865443532159624,0.31287756345535067,3398]
["Q17RN3-1","Protein Fam98c [OS=Homo sapiens]",5,2,3,2,349,37.3,7.18,6.77,"","other cell component","","FAM98C","ENSG00000130244","","","",190.8,180.8,179.9,173.7,190.4,409.7,0.7127164642026363,-0.48859984296447145,0.385425968045796,0.4140590281365422,0.5989960451725967,0.22257604499864878,4703]
["Q29963","HLA class I histocompatibility antigen, Cw-6 alpha chain [OS=Homo sapiens]",46,14,120,3,366,40.9,6,477.31,"other biological processes","plasma membrane;other membranes","","HLA-C","ENSG00000228299","","","",12043.8,11896.1,11468.5,10055.8,10727.7,17440.5,0.9263394725826706,-0.11038710479165172,0.7116173474453413,0.14775347344933049,0.81370638180194,0.08953227787129245,6392]
["Q2KHR3-1","Glutamine and serine-rich protein 1 [OS=Homo sapiens]",0,1,1,1,1735,189.9,7.08,0,"","","","QSER1","ENSG00000060749","","","",13.7,12.5,13.5,15.7,15.6,13.1,0.8941441441441442,-0.16142066920714804,0.1666267181026422,0.7782553595066667,0.4241987748562215,0.37243059011919977,2871]
["Q2NKX8","Dna excision repair protein ercc-6-like [OS=Homo sapiens]",23,21,34,21,1250,141,5.31,102.91,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","ERCC6L","ENSG00000186871","","RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",2514.1,2543,2610.4,2524.6,2567.5,5268.8,0.7400418882529509,-0.4343211616262212,0.3788057963338056,0.42158338421858604,0.5952895216950732,0.22527176184612954,4651]
["Q2TAL8","Glutamine-rich protein 1 [OS=Homo sapiens]",6,4,7,4,776,86.4,5.87,22.38,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cell component","nucleic acid binding activity","QRICH1","ENSG00000198218","","","",616,705.2,628.9,759.8,692.5,536.7,0.9804424333836098,-0.028495169732669776,0.8652711210748385,0.06284779087312885,0.9144399398403693,0.03884481359104087,6916]
["Q2TB10","zinc finger protein 800 [OS=Homo sapiens]",21,12,19,12,664,75.2,9.47,45.09,"","nucleus","nucleic acid binding activity;other molecular function","ZNF800","ENSG00000048405","","","",1399.8,1601.3,1429.3,1635.6,1579.6,1762.9,0.8899781040959401,-0.1681582526294384,0.09268928825142836,1.0329704527173789,0.32712023555272324,0.4852925897268585,2071]
["Q32MZ4-3","Isoform 3 of Leucine-rich repeat flightless-interacting protein 1 [OS=Homo sapiens]",52,30,133,27,752,82.6,4.61,441.23,"","","","LRRFIP1","","","","",12583.4,11708.6,11417.2,14100.8,14601.2,13843.5,0.839317906711638,-0.25271073408418016,5.362417883838083E-3,2.2706393452256903,0.09010094784591391,1.0452706402963545,435]
["Q32P28-1","Prolyl 3-hydroxylase 1 [OS=Homo sapiens]",4,3,6,3,736,83.3,5.14,16.19,"protein metabolism;other metabolic processes;developmental processes;other biological processes","ER/Golgi;nucleus;other cell component","other molecular function","P3H1","ENSG00000117385","","Collagen biosynthesis and modifying enzymes","Type I collagen synthesis in the context of osteogenesis imperfecta",662.4,603.9,621.4,687.9,732.5,557.1,0.9545891276864727,-0.0670481900100605,0.6177449179628416,0.20919081874623643,0.7517645030620063,0.12391818472522571,6006]
["Q3B820-3","Isoform 3 of Protein FAM161A [OS=Homo sapiens]",5,3,4,2,716,83.4,8.66,10.04,"","","","FAM161A","","","","",70.6,59.3,67.1,86,83.5,90.5,0.7576923076923076,-0.4003159935720785,0.005845544957691772,{"$f":"-LOG10(AA3331)","v":2.2331749950092328},0.0941081235589629,{"$f":"-LOG10(AC3331)","v":1.0263728859823638},454]
["Q3MHD2","Protein LSM12 homolog [OS=Homo sapiens]",18,4,11,4,195,21.7,7.74,27.54,"","","","LSM12","ENSG00000161654","","","",750.5,749.7,1018.7,1263.9,1260.4,1284.1,0.6614063648776389,-0.5963911658790145,0.008746354438293571,2.0581729272340064,0.1123499201924213,0.9494272317451047,569]
["Q3SXM5","Inactive hydroxysteroid dehydrogenase-like protein 1 [OS=Homo sapiens]",9,3,13,3,330,37,8.72,40.46,"","cytoskeleton;mitochondrion;other cell component","other molecular function","HSDL1","ENSG00000103160","","","",1162.2,1393,1312.8,1079.3,900.2,901.6,1.342542778799764,0.4249680589957846,0.021728918766325395,1.6629618836887419,0.16859518817735913,0.7731548245976464,942]
["Q460N5-1","Isoform 1 of Poly [ADP-ribose] polymerase 14 [OS=Homo sapiens]",3,3,3,3,1720,193.6,7.97,6.48,"","","","PARP14","","","","",51.4,48.6,54.7,46.5,52.5,57.8,0.9866071428571427,-0.019452362666172795,0.8595209327742327,0.06574354203959508,0.9106013186906605,0.04067172510221672,6899]
["Q49MG5","Microtubule-associated protein 9 [OS=Homo sapiens]",2,2,3,2,647,74.2,7.8,3.64,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;other cell component","cytoskeletal activity","MAP9","ENSG00000164114","","","",429.6,452.8,745.9,672.8,630.8,260.3,1.0411791035232434,0.058218262238917,0.9033169191804639,0.04415985532951782,0.9375665098395357,0.027997914179710273,7042]
["Q4G0F5","Vacuolar protein sorting-associated protein 26B [OS=Homo sapiens]",25,9,32,7,336,39.1,7.36,93.1,"stress response;transport;other biological processes","other membranes;cytosol;other cytoplasmic organelle;other cell component","","VPS26B","ENSG00000151502","Endocytosis","","",2645.8,2923.4,2865.9,2717.9,2493.8,1622.7,1.2342122205314292,0.3035904845879109,0.1964384738605077,0.7067734485810301,0.45464496689247963,0.3423276123693326,3158]
["Q4KMP7","TBC1 domain family member 10B [OS=Homo sapiens]",21,13,41,13,808,87.1,9.19,100.53,"transport;other biological processes","plasma membrane;other membranes;cytosol","enzyme regulator activity","TBC1D10B","ENSG00000169221","","TBC/RABGAPs","",2634,2717.8,2533.5,2559.6,2741.8,4049.2,0.8432934784933588,-0.24589329730988574,0.3593394599088825,0.4444950892809881,0.5879588342229735,0.23065307986885364,4467]
["Q4KMQ1","Taperin [OS=Homo sapiens]",12,4,4,4,711,75.5,7.25,13.69,"cell organization and biogenesis;developmental processes;other biological processes","other cell component","other molecular function","TPRN","ENSG00000176058","","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea","",284.2,319.5,278.3,283.9,319.4,286.7,0.9910112359550561,-0.01302668029623959,0.8841983357660704,0.053450306856397234,0.9256095153414794,0.03357218945058426,6982]
["Q504Q3","PAN2-PAN3 deadenylation complex catalytic subunit PAN2 [OS=Homo sapiens]",7,6,10,6,1202,135.3,5.99,31.96,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PAN2","ENSG00000135473","RNA degradation","Deadenylation of mRNA","Ectoderm differentiation; Ectoderm differentiation",457.2,406,496.1,459.6,526,485.4,0.9240652617267168,-0.11393334990764674,0.31541589030077977,0.5011164311843277,0.5618753941526686,0.25035998626726735,4103]
["Q53EZ4-1","Centrosomal protein of 55 kDa [OS=Homo sapiens]",21,9,13,9,464,54.1,7.01,32.64,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cell component","other molecular function","CEP55","ENSG00000138180","","","",781.6,797,1098.8,978.3,1000.4,1511.2,0.7671853061692312,-0.3823530060743179,0.25184745565570943,0.598862432339592,0.510327988186188,0.29215061277398224,3607]
["Q53FT3","Protein Hikeshi [OS=Homo sapiens]",15,3,8,3,197,21.6,5.45,23.91,"cell organization and biogenesis;stress response;transport;developmental processes","cytosol;nucleus","other molecular function","HIKESHI","ENSG00000149196","","Regulation of HSF1-mediated heat shock response","",860.3,856.1,928,712.9,786.5,662.9,1.2229570364889237,0.29037372166324077,0.01985790032003571,1.7020666736467531,0.16162738690327508,0.7914850484300844,898]
["Q53H47","Histone-lysine N-methyltransferase SETMAR [OS=Homo sapiens]",6,4,5,4,684,78,7.14,13.3,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SETMAR","ENSG00000170364","Lysine degradation; Metabolic pathways","","Histone modifications",370.4,345.3,348.7,350.6,392.1,510.5,0.8493456750718161,-0.23557625934883375,0.2645856143902269,0.5774337722451998,0.5209742067829117,0.28318377790805116,3712]
["Q53QZ3","Rho GTPase-activating protein 15 [OS=Homo sapiens]",23,10,14,10,475,54.5,9.39,36.96,"signal transduction;other biological processes","other membranes;cytosol;other cell component","enzyme regulator activity","ARHGAP15","ENSG00000075884","","RAC1 GTPase cycle; RAC3 GTPase cycle","Ectoderm differentiation; Ectoderm differentiation",1009,1001.2,1032.1,1023.6,968.2,1111.1,0.9804698830126657,-0.028454778896848495,0.6602371837135573,0.1803000204072984,0.7818654529751118,0.10686797591443614,6172]
["Q53S33","BolA-like protein 3 [OS=Homo sapiens]",7,1,1,1,107,12.1,9.64,2.1,"","cytosol;mitochondrion;nucleus","","BOLA3","ENSG00000163170","","","",76.4,72.5,93.8,69.6,75.2,54.8,1.2159318637274545,0.2820623878138728,0.18328049996276424,0.7368837391243468,0.44138292396304574,0.35518447265165026,3035]
["Q567V2-1","Mpv17-like protein 2 [OS=Homo sapiens]",5,1,1,1,206,23.2,9.25,0,"cell organization and biogenesis;other biological processes","other membranes;mitochondrion;translational apparatus;other cell component","","FKSG24; MPV17L2","ENSG00000254858; ENSGGOG00000008883; ENSPPAG00000039781; ENSPTRG00000010696","Peroxisome","","",137.9,135.9,141.8,160,183.3,496.3,0.494997617913292,-1.0145065123879426,0.26241558512836954,0.581010375339626,0.5195004094537522,0.28441410580952736,3692]
["Q56VL3","OCIA domain-containing protein 2 [OS=Homo sapiens]",55,9,40,9,154,16.9,9.03,115.42,"transport;other biological processes","ER/Golgi;other cytoplasmic organelle","","OCIAD2","ENSG00000145247","","","",3965,4055.4,3982.9,4296.2,4016.7,3990,0.9756480179469882,-0.035567330655249904,0.381904286651136,0.41804546689904115,0.5972054837683255,0.22387621307127623,4674]
["Q5BKT4","Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase [OS=Homo sapiens]",1,1,1,1,473,55.6,9.29,1.85,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","ALG10","ENSG00000139133","N-Glycan biosynthesis; Metabolic pathways","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein","",68.7,71.9,68.3,64.5,69.9,65.4,1.0455455455455456,0.06425590927468997,0.2079276523926442,0.6820877498078213,0.46660829331834097,0.3310475464887215,3257]
["Q5F1R6","DnaJ homolog subfamily C member 21 [OS=Homo sapiens]",23,10,15,10,531,62,5.47,39.69,"other biological processes","cytosol;translational apparatus;nucleus","other molecular function","DNAJC21","ENSG00000168724","","","",1384.6,1275.5,1354.7,1381.4,1536.1,1555.5,0.8975631567180863,-0.15591463764722988,0.07540543322324973,1.1225973605776411,0.300184265484059,0.5226120755588917,1836]
["Q5GJ75","Tumor necrosis factor alpha-induced protein 8-like protein 3 [OS=Homo sapiens]",10,2,2,2,292,32.6,8.59,4.37,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","transporter activity;other molecular function","TNFAIP8L3","ENSG00000183578","","PI Metabolism","",52.5,53.8,58.2,53.8,50.9,74,0.9205372132064914,-0.11945205041888662,0.5605828714691792,0.2513601761798418,0.7103502440305531,0.14852746600724148,5768]
["Q5HYK3-1","2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial [OS=Homo sapiens]",24,6,13,6,327,37.1,6.95,36.6,"other metabolic processes","other membranes;mitochondrion;other cell component","other molecular function","COQ5","ENSG00000110871","Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways; Biosynthesis of cofactors","Ubiquinol biosynthesis","",832.1,889.1,757,724.6,672.4,2468.3,0.6411404030735001,-0.6412877682506647,0.4779857863182541,0.32058501764589326,0.6525211266716697,0.18540542261283408,5354]
["Q5JRA6-1","Transport and Golgi organization protein 1 homolog [OS=Homo sapiens]",40,63,179,63,1907,213.6,4.84,539.69,"cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","MIA3","ENSG00000154305","","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cargo concentration in the ER","Type I collagen synthesis in the context of osteogenesis imperfecta",16626.1,16234.3,16823.3,17858.1,18942.9,17829.9,0.9094431905752972,-0.13694457381660735,0.015228580801727228,1.8173405680163852,0.14380581018065156,0.8422235668153049,774]
["Q5JS54-1","Proteasome assembly chaperone 4 [OS=Homo sapiens]",30,3,5,3,123,13.8,6.52,15.87,"cell organization and biogenesis","other cell component","other molecular function","PSMG4","ENSG00000180822; ENSGGOG00000012606; ENSPTRG00000033938","","","",548.6,632.5,712.3,673.8,575.4,556.4,1.0486264953478068,0.06850090359324286,0.6493422496246288,0.18752633872297517,0.7746111477895238,0.11091625717095614,6127]
["Q5JTJ3-1","Cytochrome c oxidase assembly factor 6 homolog [OS=Homo sapiens]",11,1,1,1,125,14.1,8.25,2.19,"cell organization and biogenesis;other metabolic processes","plasma membrane;other membranes;mitochondrion;nucleus","other molecular function","COA6","ENSG00000168275; ENSPTRG00000002122","Thermogenesis","Mitochondrial protein import","Mitochondrial complex IV assembly",24.6,25.4,18.7,15.8,17.9,30.8,1.0651162790697675,0.09101093850748368,0.798941292847662,0.09748513198642275,0.8723426814197134,0.05931287812420814,6694]
["Q5JTW2-1","Centrosomal protein of 78 kDa [OS=Homo sapiens]",9,5,5,5,689,76.3,8.18,17.8,"cell organization and biogenesis","cytosol;cytoskeleton","","CEP78","ENSG00000148019","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","Ciliopathies",392.2,442.3,406.4,551.9,547.2,519.7,0.7665554731900174,-0.3835378959579353,0.002182783825607273,2.660989272992032,0.06043169311122559,1.2187352379778902,264]
["Q5JWF2-1","Guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas [OS=Homo sapiens]",17,14,58,1,1037,111,5.03,185.46,"cell adhesion;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","GNAS","ENSG00000087460","","G alpha (i) signalling events; G alpha (z) signalling events; G alpha (s) signalling events; ADORA2B mediated anti-inflammatory cytokines production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Prostacyclin signalling through prostacyclin receptor; Glucagon-type ligand receptors; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation in glucagon signalling; Hedgehog 'off' state","Thyroid stimulating hormone (TSH) signaling pathway; Endothelin pathways; Corticotropin-releasing hormone signaling pathway; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; G protein signaling pathways; Thermogenesis; Hippo signaling regulation pathways; Purinergic signaling; Prostaglandin and leukotriene metabolism in senescence ; Calcium regulation in cardiac cells; Estrogen signaling pathway; Serotonin receptor 4/6/7 and NR3C signaling",6066.2,6202.6,5916.4,5142.9,5283.6,4193.7,1.2438407135333303,0.3148017455093942,0.027916010948718355,1.5541466400148802,0.18736283197812897,0.7273165578866821,1089]
["Q5MNZ9","WD repeat domain phosphoinositide-interacting protein 1 [OS=Homo sapiens]",7,1,4,1,446,48.6,6.6,18.58,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport","other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","WIPI1","ENSG00000070540","Autophagy; Autophagy; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis","XBP1(S) activates chaperone genes; Macroautophagy","Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Alzheimer's disease",52.2,52,44.4,41,42.5,145.1,0.6500437445319335,-0.621391287675882,0.4832623334216363,0.3158170534533482,0.656170238710522,0.18298347138506307,5383]
["Q5PSV4","Breast cancer metastasis-suppressor 1-like protein [OS=Homo sapiens]",5,2,4,2,323,37.6,5.15,9.87,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","BRMS1L","ENSG00000100916","","","Genotoxicity pathway",428.7,440.3,431.8,420.3,470.5,1098.3,0.65396410436881,-0.6127166455100936,0.3522510901979245,0.453147654098776,0.5836779003075562,0.23382674999321035,4411]
["Q5RKV6","Exosome complex component MTR3 [OS=Homo sapiens]",42,12,34,12,272,28.2,6.28,112.9,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cytoplasmic organelle;other cell component","","EXOSC6","ENSG00000223496","RNA degradation","Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease","",3477.9,3183.8,3145.3,3278.4,3511.4,4961.6,0.8345388634545671,-0.2609488591908679,0.29388269423792274,0.5318259873137805,0.5432444643866913,0.26500469040746105,3954]
["Q5SRD1","Putative mitochondrial import inner membrane translocase subunit Tim23B [OS=Homo sapiens]",14,2,6,2,257,28,9.39,26.68,"","","","","","","","",546,710.7,671.3,782.6,655.4,874.7,0.833657629610412,-0.26247308229092814,0.1871207180934133,0.727878124549649,0.4457840053926851,0.35087551794261934,3068]
["Q5SSJ5-1","Heterochromatin protein 1-binding protein 3 [OS=Homo sapiens]",48,24,119,24,553,61.2,9.67,300.56,"cell organization and biogenesis;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","HP1BP3","ENSG00000127483; ENSPPAG00000040189; ENSPTRG00000000296","","","",21476.1,21282,21227.9,18053.8,18472,15989.1,1.2184351488815555,0.28502946577048294,7.715663042010542E-3,2.1126267470974716,0.10640336070576424,0.9730446548142878,530]
["Q5SZL2","Centrosomal protein of 85 kDa-like [OS=Homo sapiens]",1,1,3,1,805,91.8,6.33,5.03,"developmental processes","cytoskeleton;other cell component","","CEP85L","ENSG00000111860","","","",806,581.3,492.9,550.5,695.9,240.7,1.2643399905857033,0.33838446729356314,0.46756508175099065,0.3301579298650094,0.6461397584643582,0.1896735350000209,5289]
["Q5T0D9","Tumor protein p63-regulated gene 1-like protein [OS=Homo sapiens]",31,3,10,3,272,30.2,7.34,53.52,"other biological processes","other membranes;ER/Golgi;other cell component","","TPRG1L","ENSG00000158109","","","",415.2,471.8,434.7,391.5,387.6,441.3,1.083005571943625,0.11504066547140802,0.231648882741626,0.6351697900877062,0.4920435001332591,0.30799650082466334,3441]
["Q5T3I0","G patch domain-containing protein 4 [OS=Homo sapiens]",36,16,26,16,446,50.4,9.63,81.55,"","","","GPATCH4","","","","",2145.6,2155.9,2031,2980.1,3238.9,3530.2,0.649540475115907,-0.622508667090083,2.2510820647515363E-3,2.647608672205567,0.06071276314121394,1.216720001196,271]
["Q5T4S7-1","e3 ubiquitin-protein ligase UBR4 [OS=Homo sapiens]",24,98,284,98,5183,573.5,6.04,848.76,"protein metabolism;other metabolic processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus","other molecular function","UBR4","ENSG00000127481","Human papillomavirus infection; Viral carcinogenesis","Neutrophil degranulation; Antigen processing: Ubiquitination & Proteasome degradation","",26298.4,26934.4,26454.3,24102.5,23574.9,25234.9,1.0929171072644808,0.1281839833762585,0.012693172556970403,1.896429815905029,0.13159489109063358,0.8807609710124548,705]
["Q5T5U3","rho GTPase-activating protein 21 [OS=Homo sapiens]",2,2,2,2,1957,217.2,7.8,7.72,"","","","","","","","",78,76.8,77.7,79.3,75,456.2,0.3808353808353808,-1.3927605789920094,0.37511434552301814,0.42583632677875033,0.5935723644571854,0.2265263271413241,4619]
["Q5T6V5","queuosine salvage protein [OS=Homo sapiens]",11,4,6,4,341,39,5.88,14.13,"RNA metabolism OR transcription;other metabolic processes","","","C9orf64","ENSG00000165118","","","",592.9,611.3,603.5,563.6,486.9,358.5,1.2829666430092261,0.35948366100376705,0.09137267369326253,1.0391836668334276,0.3254594892904756,0.4875030613892333,2052]
["Q5TAQ9-1","DDB1- and CUL4-associated factor 8 [OS=Homo sapiens]",20,12,20,12,597,66.8,5.39,49.73,"protein metabolism;other metabolic processes","cytosol;mitochondrion;nucleus;other cell component","","DCAF8","ENSG00000132716; ENSPPAG00000008803; ENSPTRG00000001546","","Neddylation","",2928.9,2939.2,3037.8,2433.9,2456.1,2119,1.2706377514624054,0.34555278828290875,0.005210604189103588,2.2831119157061903,0.08815811578277344,1.0547377006371295,432]
["Q5TC12-1","ATP synthase mitochondrial F1 complex assembly factor 1 [OS=Homo sapiens]",14,4,11,4,328,36.4,7.96,31.61,"cell organization and biogenesis","mitochondrion","","ATPAF1","ENSG00000123472","","","7q11.23 copy number variation syndrome",763.6,759.3,821,792,827.2,515.8,1.0978454332552694,0.1346749501782188,0.5263141160212825,0.2787549818201974,0.6855872168953046,0.16393728863968166,5611]
["Q5TF39","Sodium-dependent glucose transporter 1 [OS=Homo sapiens]",6,2,2,2,518,56.2,5.43,6.55,"transport","plasma membrane;other membranes","transporter activity","MFSD4B","ENSG00000173214","","Cellular hexose transport","",232.7,230.5,226.5,206.2,205.9,270.3,1.0106975381008205,0.015351320121045847,0.9153169314203671,0.0384285040375522,0.944789076648985,0.024665136540279985,7081]
["Q5TGZ0","MICOS complex subunit Mic10 [OS=Homo sapiens]",10,1,2,1,78,8.8,8.5,5.26,"cell organization and biogenesis","mitochondrion","","MICOS10","ENSG00000173436","","Cristae formation","",362.5,394.5,438.9,350.9,305.7,184,1.4226742802759935,0.5086053962146313,0.0956474811703178,1.0193264624190748,0.33179280487605733,0.479133036143202,2107]
["Q5VIR6-4","Isoform 4 of Vacuolar protein sorting-associated protein 53 homolog [OS=Homo sapiens]",26,17,47,17,832,94.3,6.7,140.26,"transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","VPS53","ENSG00000141252; ENSG00000283883","","Retrograde transport at the Trans-Golgi-Network","",3860.7,4003.1,3738.1,3855.7,3837.7,3836.5,1.0062446335180704,0.008981089098050034,0.7703358303500747,0.11331990148784728,0.8529593370744881,0.06907167235545951,6601]
["Q5VTE6-1","protein angel homolog 2 [OS=Homo sapiens]",11,5,8,5,544,62.3,7.81,15.84,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ANGEL2","ENSG00000174606; ENSPPAG00000031266; ENSPTRG00000001970","","","",597.9,581.4,603.2,566.8,553.2,427.7,1.151708987529883,0.20377622434478268,0.15526102815017526,0.808937542232442,0.4119066623410639,0.38520118353627286,2755]
["Q5VTY9-1","Protein-cysteine N-palmitoyltransferase HHAT [OS=Homo sapiens]",3,1,1,1,493,57.3,7.28,3.27,"protein metabolism;other metabolic processes;signal transduction","other membranes;ER/Golgi","other molecular function","HHAT","ENSG00000054392; ENSG00000280680","Hedgehog signaling pathway","Hedgehog ligand biogenesis; HHAT G278V doesn't palmitoylate Hh-Np","",66,73.8,75,51.6,65.1,56.5,1.240184757505774,0.31055506325868815,0.04598581163339468,1.3373761439666996,0.23438653921093566,0.6300673334145078,1434]
["Q5VW32","BRO1 domain-containing protein BROX [OS=Homo sapiens]",27,10,25,10,411,46.4,7.65,66.72,"","other membranes","","BROX","ENSG00000162819","","","",4343.3,4781.4,4782,4128.8,3936.4,2853.4,1.273670617112084,0.348992231676577,0.07812120082542222,1.1072310896565025,0.3042023744448647,0.5168374003938758,1877]
["Q5VYS8-1","terminal uridylyltransferase 7 [OS=Homo sapiens]",20,22,38,21,1495,171.1,6.83,111.51,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TUT7","ENSG00000083223","","Deadenylation of mRNA","",2999.1,3123.1,3095.3,3878.7,3931.4,3905.8,0.7867513379253833,-0.34602036795829394,3.3138205418615088E-5,4.479671014259946,0.018631318723435205,1.72975640468281,13]
["Q5VZE5","N-alpha-acetyltransferase 35, NatC auxiliary subunit [OS=Homo sapiens]",10,5,5,5,725,83.6,7.05,14.31,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","","NAA35","ENSG00000135040","","Retrograde transport at the Trans-Golgi-Network","",196.1,184.2,202.6,170.3,173.1,273.2,0.9453454427505676,-0.08108648780067441,0.7595042870093259,0.11946977042629085,0.8455775832065747,0.07284653896781605,6565]
["Q5W0Z9-1","Probable palmitoyltransferase ZDHHC20 [OS=Homo sapiens]",5,1,2,1,365,42.3,7.71,5.62,"protein metabolism;other metabolic processes;transport","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","ZDHHC20","ENSG00000180776; ENSPPYG00000005201","","","",68.6,73.4,71.1,64.9,73.8,185.9,0.6565003080714725,-0.6071324067652681,0.39411507619604175,0.40437695162636456,0.6035170944724217,0.21931042410863555,4773]
["Q5XKP0","MICOS complex subunit MIC13 [OS=Homo sapiens]",75,5,22,5,118,13.1,9.42,65.16,"cell organization and biogenesis","other membranes;mitochondrion;nucleus","","MICOS13","ENSG00000174917","","Cristae formation","",2695.5,2957.5,2657.2,2745.9,2400.8,4536.8,0.8581814426601952,-0.2206453903421636,0.5312335155824649,0.2747145330877905,0.6881931523204956,0.16228965302316498,5642]
["Q63ZY3-1","KN motif and ankyrin repeat domain-containing protein 2 [OS=Homo sapiens]",3,2,3,2,851,91.1,5.63,9.86,"developmental processes;other biological processes","mitochondrion;other cell component","","KANK2","ENSG00000197256","","","",182.5,158.3,156.6,179.5,205.8,246.4,0.7873990818426466,-0.3448330646635005,0.10207709983635643,0.9910716774058219,0.3416124188204804,0.4664663495545485,2184]
["Q66K14-1","TBC1 domain family member 9B [OS=Homo sapiens]",14,14,25,12,1250,140.4,5.25,84.37,"transport;other biological processes","other membranes","enzyme regulator activity;other molecular function","TBC1D9B","ENSG00000197226; ENSG00000284400","","","",1654.9,1597.9,1600.8,1432.5,1442.3,1248.5,1.177115417262872,0.23525578490412902,0.020739483727195526,1.683202058806227,0.1651251487604271,0.7821867781234965,918]
["Q676U5","Autophagy-related protein 16-1 [OS=Homo sapiens]",12,6,7,6,607,68.2,6.64,17.74,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","ATG16L1","ENSG00000085978; ENSG00000281089","Autophagy; Autophagy; NOD-like receptor signaling pathway; Shigellosis","Macroautophagy","Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; LDLRAD4 and what we know about it; Autophagy; Senescence and autophagy in cancer",469.9,441.4,465.6,404.9,438.9,602,0.9523447226449026,-0.0704442108188698,0.7276592220816367,0.1380719621970612,0.8239289317110275,0.08411024691552733,6455]
["Q68CZ6","HAUS augmin-like complex subunit 3 [OS=Homo sapiens]",4,3,4,3,603,69.6,5.55,2.05,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","non-structural extracellular;cytosol;cytoskeleton;mitochondrion;nucleus","","HAUS3","ENSG00000214367","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",261.1,264,229,238.9,259.9,73.6,1.3174353598881903,0.39773217760706664,0.3696552408536055,0.432203132134754,0.5918532651476457,0.22778595212109878,4565]
["Q68DQ2","very large A-kinase anchor protein [OS=Homo sapiens]",5,13,14,13,2970,330.4,5.2,33.18,"developmental processes;other biological processes","other cell component","other molecular function","CRYBG3","ENSG00000080200","","","",1018.1,977.5,1093.9,1106.4,1246.4,1336.5,0.837421733120104,-0.2559737348964006,0.056326277224781396,1.2492889516611982,0.25827400265741984,0.5879193068373189,1594]
["Q69YH5-1","cell division cycle-associated protein 2 [OS=Homo sapiens]",23,18,40,17,1023,112.6,8.4,106.03,"cell cycle OR cell proliferation;other biological processes","cytosol;nucleus;other cell component","","CDCA2","ENSG00000184661","","","",3362.4,3544.9,3420.9,2862.2,2915.8,4265.1,1.028387649231811,0.040384188855759416,0.8471038303173146,{"$f":"-LOG10(AA3651)","v":0.07206335452146627},0.9030749556285373,{"$f":"-LOG10(AC3651)","v":0.044276201552635085},6856]
["Q6BCY4","NADH-cytochrome b5 reductase 2 [OS=Homo sapiens]",4,1,1,1,276,31.4,8.5,2.31,"other metabolic processes;transport","other membranes;ER/Golgi","other molecular function","CYB5R2","ENSG00000166394","Amino sugar and nucleotide sugar metabolism","Erythrocytes take up carbon dioxide and release oxygen","Oxidation by cytochrome P450",69.2,78.3,67.8,74,60.3,48.6,1.177145981410607,0.23529324441851726,0.25053580623301847,0.6011301965905866,0.5089400243905314,0.2933333937161462,3598]
["Q6DD87","Zinc finger protein 787 [OS=Homo sapiens]",14,3,5,3,383,40.5,7.84,20.81,"","","","","","","","",570.1,569.7,610.6,617.3,722.8,619.7,0.8931523624859681,-0.16302178980627552,0.13483356329276863,0.8702019880789462,0.38616712935221237,0.41322469624409797,2552]
["Q6DT37","Serine/threonine-protein kinase MRCK gamma [OS=Homo sapiens]",4,5,5,5,1551,172.4,6.28,16.18,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction","cytosol;cytoskeleton;other cell component","kinase activity;other molecular function","CDC42BPG","ENSG00000171219","","","",415.1,406.7,381.9,499.8,468.7,724.4,0.7110284127827986,-0.49202088361956603,0.11492339257101632,0.9395915619950534,0.3609690916637552,0.4425299833978104,2327]
["Q6IA69","glutamine-dependent NAD(+) synthetase [OS=Homo sapiens]",14,8,12,8,706,79.2,6.44,32.21,"other metabolic processes","cytosol;other cell component","other molecular function","NADSYN1","ENSG00000172890","Nicotinate and nicotinamide metabolism; Metabolic pathways; Biosynthesis of cofactors","Nicotinate metabolism","NAD biosynthesis II (from tryptophan); NAD+ biosynthetic pathways",789.5,770.3,844.4,792.5,839.6,724.2,1.0203284810932394,0.02903368332764316,0.7114466826561967,0.14785764132226975,0.8136385234758475,0.08956849698685258,6391]
["Q6IAN0","Dehydrogenase/reductase SDR family member 7B [OS=Homo sapiens]",23,6,11,6,325,35.1,9.55,27.45,"other metabolic processes","other membranes;ER/Golgi;other cytoplasmic organelle","other molecular function","DHRS7B","ENSG00000109016","","Plasmalogen biosynthesis","",1157.4,1159.2,1228.6,1030.5,1020,1536.2,0.9884294755624948,-0.01679006154383066,0.9397434471200601,0.0269906939616048,0.9613134856543764,0.017134965204620878,7145]
["Q6IEG0-1","U11/U12 small nuclear ribonucleoprotein 48 kDa protein [OS=Homo sapiens]",2,1,1,1,339,39.9,6.95,1.64,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","other molecular function","SNRNP48","ENSG00000168566","","mRNA Splicing - Minor Pathway","",120,130.6,106.3,111.7,109.8,159.8,0.9360083923419877,-0.0954066296770927,0.6715585439485356,0.17291612118510347,0.7876157570153798,0.10368560396563857,6232]
["Q6JQN1","Acyl-CoA dehydrogenase family member 10 [OS=Homo sapiens]",2,2,2,2,1059,118.8,8.06,3.95,"other metabolic processes","mitochondrion","other molecular function","ACAD10","ENSG00000111271","","Mitochondrial Fatty Acid Beta-Oxidation","",124.3,158.4,148.7,123.2,133.3,186.3,0.9742547425474254,-0.037629045621098374,0.8714927783834759,0.05973620731612374,0.9182270026243082,0.0370499399316829,6937]
["Q6KCM7-3","Isoform 3 of Calcium-binding mitochondrial carrier protein SCaMC-2 [OS=Homo sapiens]",14,6,14,6,515,56.8,8.46,36.72,"","","","SLC25A25","","","","",1172.6,1079.1,1197.5,1120.5,1208.3,2127.7,0.7739706047346573,-0.3696493207771821,0.35873498814985333,0.4452262636379954,0.5874958611667663,0.23099518859455184,4463]
["Q6NT16","MFS-type transporter SLC18B1 [OS=Homo sapiens]",2,1,1,1,456,48.8,5.22,2.8,"transport","other membranes","transporter activity","SLC18B1","ENSG00000146409","","","",78.8,83.4,72.6,71,63,59.7,1.2121837893649974,0.27760845450679844,0.04048395163452672,1.39271710265766,0.22081880783339985,0.6559639391384945,1340]
["Q6NUK1","Calcium-binding mitochondrial carrier protein SCaMC-1 [OS=Homo sapiens]",32,14,38,14,477,53.3,6.33,111,"stress response;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","SLC25A24","ENSG00000085491; ENSG00000284468","","","",4778.3,4475.1,4658.6,3989.5,4226,3767.7,1.160958675479004,0.2153166201427008,0.015559824565579226,1.8079953039164065,0.14505963998701346,0.838453404716872,784]
["Q6NW29","RWD domain-containing protein 4 [OS=Homo sapiens]",11,2,3,2,188,21.2,5.31,8.35,"","","","RWDD4","ENSG00000182552","","","",263.5,258.6,312.7,378.6,393.2,504.5,0.6540781947817911,-0.6124649752490554,0.027403496669529293,1.5621940179317189,0.18683969884103507,0.7285308414044971,1072]
["Q6NXR4","TELO2-interacting protein 2 [OS=Homo sapiens]",24,10,19,10,508,56.9,7.09,61.94,"","cytosol;cytoskeleton;nucleus","","TTI2","ENSG00000129696","","","",1511.1,1569.1,1491.8,1596.3,1613.9,1698.2,0.9314644283269498,-0.10242741971530156,0.045550164195788376,1.341510053176245,0.23379645372683794,0.6311620805931095,1424]
["Q6P0N0","Mis18-binding protein 1 [OS=Homo sapiens]",3,3,3,3,1132,129,9.25,5.18,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","nucleic acid binding activity","MIS18BP1","ENSG00000129534","","Deposition of new CENPA-containing nucleosomes at the centromere","",168.4,198.5,168.6,202.9,206.1,571.1,0.5463728191000918,-0.872042380521601,0.29334389888502344,0.5326229400303061,0.5425229142081569,0.26558191406192366,3952]
["Q6P1L8","39S ribosomal protein L14, mitochondrial [OS=Homo sapiens]",13,1,1,1,145,15.9,10.24,5.95,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL14","ENSG00000180992","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",43.9,38.5,33.4,34.3,45.7,52.2,0.8759455370650531,-0.19108692351845488,0.41705407424883845,0.37980763177595916,0.6175543413056646,0.20932482091717144,4936]
["Q6P1X5","Transcription initiation factor TFIID subunit 2 [OS=Homo sapiens]",6,6,9,6,1199,136.9,8.19,23.55,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","TAF2","ENSG00000064313","Basal transcription factors","Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation","",553.7,530,586.5,547,540.5,737.8,0.9150276666849286,-0.12811272964837456,0.4818614954142364,0.3170777759134236,0.6548764726631934,0.18384061191673345,5378]
["Q6P1X6","UPF0598 protein C8orf82 [OS=Homo sapiens]",24,4,5,4,216,23.9,9.14,16.32,"","","","C8orf82","ENSG00000213563","","","",243.9,271.9,321.6,283.5,230.3,341.8,0.9787283777466106,-0.031019564424742126,0.8851055675444037,0.05300492741770214,0.9261612874992193,0.03331337598392987,6985]
["Q6P3X3","tetratricopeptide repeat protein 27 [OS=Homo sapiens]",25,16,26,16,843,96.6,5.59,62.23,"","","","TTC27","ENSG00000018699","","","",2151,2009.7,2086.3,2135.3,2182.2,1707.7,1.0368120560313352,0.05215439906385582,0.6610220716037746,0.1797840391290458,0.7824146269395933,0.10656303917677616,6175]
["Q6P4E1","Protein CASC4 [OS=Homo sapiens]",32,16,37,16,433,48.8,5.82,88.85,"","","","","","","","",3792.3,3769.8,3782.6,4092.6,4348.4,5297.2,0.8257777583671806,-0.27617453363350025,0.09505825897029908,1.0220101442440397,0.3308480070542457,0.480371477093986,2100]
["Q6P6C2-2","RNA demethylase ALKBH5 [OS=Homo sapiens]",24,6,10,6,394,44.2,9.09,30.01,"RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes","cytosol;ER/Golgi;nucleus","other molecular function","ALKBH5","ENSCSAG00000008183; ENSG00000091542; ENSMFAG00000001517; ENSMMUG00000018352; ENSMNEG00000037007; ENSPANG00000023682; ENSPPAG00000030479; ENSPTRG00000024216; ENSRBIG00000029698; ENSRROG00000033654","","Reversal of alkylation damage by DNA dioxygenases","",951.9,926.2,933.1,1064,1033.6,1287.4,0.8304874446085672,-0.26796973734134544,0.07603713295063602,1.1189742669669371,0.3012224415914356,0.5211126755780435,1845]
["Q6PD62","RNA polymerase-associated protein CTR9 homolog [OS=Homo sapiens]",14,15,24,15,1173,133.4,6.77,58.56,"cell-cell signaling;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes","nucleus;other cell component","other molecular function","CTR9","ENSG00000198730","","E3 ubiquitin ligases ubiquitinate target proteins; RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex","Endoderm differentiation",2120.1,2269.3,2222.7,2809.9,2564.6,3508.2,0.7443795242437546,-0.4258897233676141,0.05724056796537686,1.2422960656354387,0.26018116371824596,0.5847241481638982,1608]
["Q6PGP7","Tetratricopeptide repeat protein 37 [OS=Homo sapiens]",26,38,67,38,1564,175.4,7.53,178.13,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","","TTC37","ENSG00000198677","RNA degradation","mRNA decay by 3' to 5' exoribonuclease","",6221.2,6487.4,6278.6,6128.1,5979.8,6596.4,1.015124864336008,0.021657195468435964,0.6659060322263233,0.17658705095707253,0.7853973195969335,0.10491058522277838,6197]
["Q6PII5-1","Hydroxyacylglutathione hydrolase-like protein [OS=Homo sapiens]",2,1,1,1,290,31.5,8.21,2.02,"","","other molecular function","HAGHL","ENSG00000103253","","","Orexin receptor pathway",185.8,167.1,181.5,201.9,185.8,367.2,0.7079083322294343,-0.4983655385340901,0.2755490668387211,0.5598010553969223,0.5294395713786048,0.2761836017783256,3804]
["Q6PJG6-1","BRCA1-associated ATM activator 1 [OS=Homo sapiens]",23,12,25,12,821,88.1,5.27,67.16,"cell cycle OR cell proliferation;other metabolic processes;stress response;other biological processes","nucleus;other cell component","","BRAT1","ENSG00000106009","","","",1248.6,1229.7,1250.7,1502.1,1409,1604.8,0.825749020128878,-0.27622474234271055,0.009980009203003294,2.000869058230494,0.11977649797167665,0.9216283889793965,609]
["Q6PJI9-1","GATOR complex protein WDR59 [OS=Homo sapiens]",4,3,3,3,974,109.7,7.91,9.14,"stress response;other biological processes","other membranes;other cytoplasmic organelle;other cell component","","WDR59","ENSG00000103091","mTOR signaling pathway","Amino acids regulate mTORC1","",269.3,259.1,275.8,248.9,250.8,341,0.9565837992149399,-0.06403673696287782,0.7127631297418486,0.1470547738474554,0.8141249750403455,0.08930892213257367,6399]
["Q6Q0C0-1","E3 ubiquitin-protein ligase TRAF7 [OS=Homo sapiens]",2,1,1,1,670,74.6,7.15,3.82,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;nucleus;other cell component","other molecular function","TRAF7","ENSG00000131653","","Antigen processing: Ubiquitination & Proteasome degradation","",46.4,47.1,41.4,42.5,57.8,45.8,0.9233401779603013,-0.11506582985523055,0.49539052696064173,0.30505230240915526,0.6652231051911318,0.17703267484225607,5443]
["Q6QNY1","biogenesis of lysosome-related organelles complex 1 subunit 2 [OS=Homo sapiens]",21,1,3,1,142,16,4.86,11.69,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","BLOC1S2","ENSG00000196072","","","Genotoxicity pathway",40.7,50.8,98.2,83.3,114.1,26.1,0.8487695749440717,-0.23655515265920427,0.7369742952593642,0.13254765952452763,0.8307441585519267,0.080532703817032,6484]
["Q6SZW1","Sterile alpha and TIR motif-containing protein 1 [OS=Homo sapiens]",8,4,6,4,724,79.3,6.55,17.3,"other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;mitochondrion;other cell component","other molecular function","SARM1","ENSG00000004139","","","Regulation of toll-like receptor signaling pathway",334.3,309.1,324.9,316.3,305.4,528.7,0.8417072322670376,-0.2486095813158888,0.45276300091280186,0.34412907023836736,0.6365156325585053,0.19619092578797379,5199]
["Q6UW02","Cytochrome P450 20A1 [OS=Homo sapiens]",35,13,34,13,462,52.4,6.21,71.7,"","other membranes","other molecular function","CYP20A1","ENSG00000119004","","","Oxidation by cytochrome P450; Metapathway biotransformation Phase I and II",3049.5,3156.9,3180.6,2653.4,2775.9,2638.3,1.1635430611334225,0.21852460389673467,1.7720071088517934E-3,2.751534540164028,0.05534871777178529,1.2568924356901978,234]
["Q6UWI2","Prostate androgen-regulated mucin-like protein 1 [OS=Homo sapiens]",7,1,3,1,310,32.3,4.68,13.41,"other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","","PARM1","ENSG00000169116","","","",76.2,111.1,75.8,123.1,111.3,254.9,0.5377069282648682,-0.8951080342671514,0.18754830428870428,0.7268868581535562,0.4460756772034297,0.3505914565259615,3073]
["Q6UWP7-1","Lysocardiolipin acyltransferase 1 [OS=Homo sapiens]",9,3,5,3,414,48.9,8.62,18.6,"other metabolic processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","LCLAT1","ENSG00000172954","Glycerolipid metabolism; Glycerophospholipid metabolism; Metabolic pathways","Synthesis of PA; Acyl chain remodeling of CL","",360.2,343,357.8,327,368.6,399,0.9693038552896037,-0.044979105405360785,0.6306955056358965,0.20018026379736417,0.7620686808882076,0.11800588642074195,6049]
["Q6UXV4","MICOS complex subunit MIC27 [OS=Homo sapiens]",47,8,19,8,268,29.1,9.52,61.94,"cell organization and biogenesis","non-structural extracellular;other membranes;mitochondrion;other cell component","","APOOL","ENSG00000155008","","Platelet degranulation ; Cristae formation","",2186,2053.5,2043.9,1902.9,1916.6,1422.9,{"$f":"AVERAGE(S3842:U3842)/AVERAGE(V3842:X3842)","v":1.1985731725927058},{"$f":"LOG(Y3842,2)","v":0.26131798784743737},{"$f":"TTEST(V3842:X3842,S3842:U3842,2,2)","v":0.10880755107989884},0.9633409642101054,{"$f":"AA3842*7309/AE3842","v":0.34911079492668157},0.45703672206921403,2278]
["Q6V1X1","Dipeptidyl peptidase 8 [OS=Homo sapiens]",9,6,11,5,898,103.3,5.8,24.15,"protein metabolism;other biological processes","cytosol;other cell component","other molecular function","DPP8","ENSG00000074603","","","",407.2,424.6,400.4,426.3,409.7,484.3,0.9332727410437022,-0.0996293368010213,0.28363620982449983,{"$f":"-LOG10(AA3843)","v":0.5472383266514105},0.5354072979357617,{"$f":"-LOG10(AC3843)","v":0.2713157134037935},3872]
["Q6Y1H2","Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 [OS=Homo sapiens]",9,2,10,2,254,28.4,9.55,22.85,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","HACD2","ENSG00000206527","Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism","Synthesis of very long-chain fatty acyl-CoAs","",1195.9,1203,1068.1,933.8,927,1353.2,1.0787181082762913,0.10931790752773976,0.5983368706331285,0.22305423429795818,0.7378512210996349,0.13203119965300336,5927]
["Q6YHK3-1","CD109 antigen [OS=Homo sapiens]",2,2,2,2,1445,161.6,5.85,5.29,"developmental processes;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytosol","enzyme regulator activity;other molecular function","CD109","ENSG00000156535","","Platelet degranulation ; Post-translational modification: synthesis of GPI-anchored proteins","",45.9,44.9,39.4,36.7,25.6,114.5,0.7364253393665158,-0.4413888262257962,0.6091130117227491,0.21530212310729194,0.7446072926378279,0.12807271464346906,5979]
["Q6ZMS4","Zinc finger protein 852 [OS=Homo sapiens]",18,7,10,3,543,62,8.12,25.13,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF852","ENSG00000178917; ENSG00000281626","","","",1317.3,1325.1,1340.4,1531.1,1638.5,658.2,1.04049323371127,0.05726758331165622,0.8759132035889183,0.05753892701682295,0.92129077637522,0.03560327681230085,6949]
["Q6ZQN7","Solute carrier organic anion transporter family member 4C1 [OS=Homo sapiens]",5,2,2,2,724,78.9,7.53,6.93,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle","transporter activity","SLCO4C1","ENSG00000173930","","Neutrophil degranulation; Transport of organic anions","",104.1,114,93.9,117.3,143.8,202.2,0.673429743146989,-0.5704006532836607,0.12165881732900827,0.9148564097207212,0.3701932955277774,0.4315714509036356,2402]
["Q6ZSR9","Uncharacterized protein FLJ45252 [OS=Homo sapiens]",15,4,6,4,355,38,5.26,18.58,"","","","","","","","",309.8,350.9,322,401.7,378.9,961.2,0.5641864737627741,-0.8257560168215357,0.25544648872136894,0.5927000626016606,0.512365089479826,0.29042046901864826,3644]
["Q6ZT07","TBC1 domain family member 9 [OS=Homo sapiens]",2,3,3,1,1266,143.1,5.31,4.78,"transport;other biological processes","","enzyme regulator activity;other molecular function","TBC1D9","ENSG00000109436","","","",52.1,42.8,44.3,68.7,77.2,94.5,0.579034941763727,-0.7882776848624574,0.014208865001830107,1.8474406119478919,0.13884036670905917,0.8574842479283803,748]
["Q6ZVF9","G protein-regulated inducer of neurite outgrowth 3 [OS=Homo sapiens]",23,13,20,13,776,82.4,7.56,69.33,"cell organization and biogenesis;developmental processes","plasma membrane;other membranes","","GPRIN3","ENSG00000185477","","","",1731.1,1652.5,1629.9,2739.6,2930.8,3050.3,0.5748965106012132,-0.7986258207085724,2.0610247416966536E-4,3.685916794675016,0.023537546620407565,1.6282388067749305,64]
["Q6ZVK8-1","8-oxo-dGDP phosphatase NUDT18 [OS=Homo sapiens]",24,6,8,6,323,35.5,6.23,28.93,"other metabolic processes","cytosol","other molecular function","NUDT18","ENSG00000275074; ENSPTRG00000020049","","","",367.5,386.5,357.2,372.8,349.9,1518.9,0.4957173447537473,-1.0124103564494256,0.38425816098786214,0.4153769000563032,0.5985811804476309,0.2228769416158219,4692]
["Q70CQ3","ubiquitin carboxyl-terminal hydrolase 30 [OS=Homo sapiens]",2,1,1,1,517,58.5,8.27,2.23,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle","other molecular function","USP30","ENSG00000135093","Mitophagy","Ub-specific processing proteases; Pexophagy","",121.4,137,112,124.6,114.4,139.7,0.9780829152363347,-0.03197132262418313,0.8024790343149228,0.09556630521627443,0.874898457906887,0.05804234895452159,6704]
["Q70IA6-1","MOB kinase activator 2 [OS=Homo sapiens]",8,2,5,2,237,26.9,6.79,14.96,"other metabolic processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","MOB2","ENSCATG00000043655; ENSCSAG00000009929; ENSG00000182208","","","",624.8,673.2,640.6,687.7,671.8,722.1,0.9313028439661798,-0.1026777107312756,0.08144579777437749,1.0891313183595186,0.309884089501783,0.5088007213372393,1921]
["Q71RC2","La-related protein 4 [OS=Homo sapiens]",8,5,8,5,724,80.5,6.61,23.37,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;other cell component","nucleic acid binding activity","LARP4","ENSG00000161813","","","",701.9,724.9,701.8,1382.8,1445.9,1287.4,0.5171400111756274,-0.9513731642846891,1.4344218562995764E-4,3.8433231060462743,0.021396304791211438,1.669661224190815,49]
["Q76I76","Protein phosphatase Slingshot homolog 2 [OS=Homo sapiens]",3,2,2,2,1423,158.1,5.41,7.71,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","SSH2","ENSG00000141298","Axon guidance; Regulation of actin cytoskeleton","","Regulation of actin cytoskeleton",88.9,90.2,91.2,90,90.1,236.6,0.6486681065514759,-0.624447588167854,0.3743805746292139,0.42668669345477694,0.5936965979529019,0.22643543969532431,4609]
["Q7L014","probable ATP-dependent RNA helicase DDX46 [OS=Homo sapiens]",46,46,192,45,1031,117.3,9.29,604.08,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus","other molecular function","DDX46","ENSG00000145833","Spliceosome","mRNA Splicing - Major Pathway","",22230.6,22696.5,22815.5,22540.3,22738.4,19559.7,1.0447913582074821,0.06321486906936757,0.4060748698165954,0.3913938862491442,0.6106998402241761,0.21417219362746456,4860]
["Q7L0Y3","Mitochondrial ribonuclease P protein 1 [OS=Homo sapiens]",38,16,56,16,403,47.3,9.36,174.21,"RNA metabolism OR transcription;other metabolic processes;other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","TRMT10C","ENSG00000174173","","tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion","",8141.5,7495.8,8013.5,6857,7254.7,5249.9,1.2215312784067434,0.2886908055818823,0.0905475271910923,1.043123405558951,0.3242586360802026,0.4891084483910485,2041]
["Q7L2J0-1","7SK snRNA methylphosphate capping enzyme [OS=Homo sapiens]",30,13,34,13,689,74.3,9.57,115.51,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MEPCE","ENSG00000146834","","","IL-18 signaling pathway",2135,2106.1,2059.6,2596.3,2620.8,3753.8,0.7023487052581123,-0.5097406107373308,0.08049019125588708,1.0942570406630923,0.30801194130328724,0.5114324460268468,1910]
["Q7L2Z9","Centromere protein Q [OS=Homo sapiens]",15,3,5,3,268,30.6,9.42,19.29,"cell cycle OR cell proliferation;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","","CENPQ","ENSG00000031691","","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Deposition of new CENPA-containing nucleosomes at the centromere","",261.5,285.6,271.9,290.6,318.1,302.2,0.8991107695685584,-0.1534292295783169,0.0444953795876098,1.3516850839355974,0.23147098178351605,0.6355034462927232,1405]
["Q7L5D6","Golgi to ER traffic protein 4 homolog [OS=Homo sapiens]",20,7,23,7,327,36.5,5.41,65.88,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","GET4","ENSG00000239857","","Insertion of tail-anchored proteins into the endoplasmic reticulum membrane","",1689.7,1875.3,1868.9,1651.8,1477.8,1927.7,1.0744666126193818,0.10362065395526529,0.4337604381265722,0.36275006109737656,0.6248236188937951,0.2042425620991155,5074]
["Q7L8L6","FAST kinase domain-containing protein 5, mitochondrial [OS=Homo sapiens]",7,4,8,4,764,86.5,8.13,30.2,"RNA metabolism OR transcription;other metabolic processes;other biological processes","mitochondrion;other cell component","nucleic acid binding activity","FASTKD5","ENSG00000215251","","","",507.9,511.3,487.6,470,491.7,657.8,0.9304106205619018,-0.10406052973515635,0.563796258545781,0.24887781051179703,0.7120765256110443,0.14747333099137097,5787]
["Q7LBC6-1","Lysine-specific demethylase 3B [OS=Homo sapiens]",14,15,21,15,1761,191.5,7.18,59.58,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KDM3B","ENSG00000120733","Thermogenesis","HDMs demethylate histones","Thermogenesis",1245,1278.7,1215.1,1460.1,1442.7,1951.7,0.7701720053558554,-0.37674741068817924,0.09105066975763228,1.040716855240021,0.3249459693645187,0.48818884565984133,2048]
["Q7Z2E3-4","Isoform 4 of Aprataxin [OS=Homo sapiens]",33,7,22,7,254,29.1,8.59,61.07,"","","","APTX","","","","",1694.6,1704.7,1628.8,1682.1,1633.9,1614.5,1.0197951526214382,0.028279385552503724,0.35520698331034656,0.4495185046520615,0.5864485748848708,0.23177006474693648,4427]
["Q7Z2Z1","Treslin [OS=Homo sapiens]",0,1,2,1,1910,210.7,8.78,0,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","other molecular function","TICRR","ENSG00000140534","","","",86.8,91.8,77.1,88.5,92.2,69.6,1.02157411106672,0.030793869553317105,0.8374265903357431,0.0770532533173175,0.8976024268608221,0.046915981877977776,6819]
["Q7Z392","trafficking protein particle complex subunit 11 [OS=Homo sapiens]",8,8,9,8,1133,128.8,7.14,27.94,"cell organization and biogenesis;transport;other biological processes","cytosol;ER/Golgi;other cell component","","TRAPPC11","ENSG00000168538","","RAB GEFs exchange GTP for GDP on RABs","Genes related to primary cilium development (based on CRISPR)",648.2,615.5,643.8,610.9,579.4,871.1,0.9253420005821287,-0.1119414196872289,0.6105709159856063,0.21426388678447783,0.7456412405912777,0.1274700796429343,5985]
["Q7Z3K3-1","Pogo transposable element with ZNF domain [OS=Homo sapiens]",11,13,34,13,1410,155.2,7.4,119.03,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","POGZ","ENSG00000143442; ENSPTRG00000001289","","","",2681.5,2867.5,2914.5,2664,2700.4,2824.5,1.033533197376937,0.04758472927800969,0.3478836364282421,0.4585659988926944,0.5807860892311607,0.23598379424063431,4378]
["Q7Z3K6-1","Mesoderm induction early response protein 3 [OS=Homo sapiens]",5,2,2,2,550,61.4,4.51,6.44,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","MIER3","ENSG00000155545; ENSGGOG00000015237","","","",22.6,27.8,23,33.8,30,25,0.8265765765765767,-0.274779613506893,0.16733055620481319,0.7764247453531311,0.4242174940343321,0.372411425857366,2883]
["Q7Z434","Mitochondrial antiviral-signaling protein [OS=Homo sapiens]",40,11,31,11,540,56.5,5.52,126.96,"stress response;signal transduction;other biological processes","other membranes;mitochondrion;other cytoplasmic organelle","other molecular function","MAVS","ENSG00000088888","NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; Hepatitis C; Hepatitis B; Measles; Influenza A; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease","Ovarian tumor domain proteases; TRAF6 mediated NF-kB activation; Negative regulators of DDX58/IFIH1 signaling; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10","Novel intracellular components of RIG-I-like receptor (RLR) pathway; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation",1349.4,1384.8,1377.9,1411.2,1440.1,2001.7,0.8473315474963939,-0.23900151100079967,0.26881021211775735,0.5705542364286839,0.5233707619522345,0.2811905428300384,3754]
["Q7Z4G4","tRNA (guanine(10)-N2)-methyltransferase homolog [OS=Homo sapiens]",3,2,2,2,463,53.4,7.78,4.86,"RNA metabolism OR transcription;other metabolic processes","other cell component","nucleic acid binding activity;other molecular function","TRMT11","ENSG00000066651","","tRNA modification in the nucleus and cytosol","",315,330.7,362,352.9,323.1,356.1,0.976358879953493,-0.03451655861342945,0.6637494608876363,0.17799581865415778,0.7838656987603383,0.10575833946299883,6189]
["Q7Z4H8","KDEL motif-containing protein 2 [OS=Homo sapiens]",2,1,1,1,507,58.5,8.24,0,"protein metabolism;other metabolic processes","ER/Golgi;other cell component","other molecular function","POGLUT3","ENSG00000178202","","","",148.1,158.9,148,197.2,201.5,103.9,0.9052924791086351,-0.14354412590723453,0.6464749900015825,0.18944827188862087,0.772072827111367,0.11234173215020911,6120]
["Q7Z5D8","NANOG neighbor homeobox [OS=Homo sapiens]",4,1,1,1,188,22.7,9.72,2.13,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","NANOGNB","ENSG00000205857","","","Pre-implantation embryo",85.1,73.1,71.8,69,80.4,135.7,0.8067344791301297,-0.30983417810621516,0.4317340385457906,0.36478370957897305,0.6239952714516874,0.20481870132754465,5057]
["Q7Z5U6","WD repeat-containing protein 53 [OS=Homo sapiens]",13,2,2,2,358,39,6.52,11.19,"","","","WDR53","ENSG00000185798","","","3q29 copy number variation syndrome",84.8,73.7,67.6,83.5,87.3,141.8,0.7232885476647472,-0.4673567862481357,0.21319215526112975,0.6712287798963291,0.4733358027957465,0.32483064455258837,3292]
["Q7Z5W3","Pre-miRNA 5'-monophosphate methyltransferase [OS=Homo sapiens]",3,1,1,1,292,33.2,6.7,2.56,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","BCDIN3D","ENSG00000186666","","MicroRNA (miRNA) biogenesis","",85.1,83.1,80.9,102.2,111.6,105.9,0.7791679699718486,-0.3599937225396838,1.4101171390116963E-3,2.8507448088245324,0.051791689291640644,1.2857399233502662,199]
["Q7Z6K3","Protein prenyltransferase alpha subunit repeat-containing protein 1 [OS=Homo sapiens]",4,1,1,1,402,46.4,6.99,2.39,"protein metabolism;other metabolic processes","other cell component","other molecular function","PTAR1","ENSG00000188647","","","",98,100.2,107.5,116,103.8,96,0.9680177327422419,-0.04689461897326698,0.631292116940543,0.19976963375295342,0.7625374454996577,0.1177388248014083,6051]
["Q7Z6L1-1","Tectonin beta-propeller repeat-containing protein 1 [OS=Homo sapiens]",9,6,7,6,1165,129.6,6.24,25,"cell organization and biogenesis;other metabolic processes","other membranes;nucleus;other cytoplasmic organelle;other cell component","other molecular function","TECPR1","ENSG00000205356","Shigellosis","","",337.4,279.2,333.2,298,373.1,370.7,0.9116913035131503,-0.13338268089236502,0.3779699143297594,0.4225427677833349,0.595127553605388,0.22538994201926085,4642]
["Q7Z7A3","Cytoplasmic tRNA 2-thiolation protein 1 [OS=Homo sapiens]",10,2,3,2,348,36.4,9.2,9.81,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol","nucleic acid binding activity;other molecular function","CTU1","ENSG00000142544","Sulfur relay system","tRNA modification in the nucleus and cytosol","",274.3,285.7,268,319.8,318.2,540.9,0.7023496479769276,-0.5097386742991531,0.18982759914041514,0.7216406450014106,0.4481427397019684,0.3485836351282926,3096]
["Q7Z7H8","39S ribosomal protein L10, mitochondrial [OS=Homo sapiens]",33,5,16,5,261,29.3,9.58,50.63,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus;other cell component","other molecular function","MRPL10","ENSG00000159111","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1406.9,1421.2,1436.3,1131.5,1042.9,1058.3,1.3191449871624341,0.39960313984704565,2.7492516804101613E-4,3.5607855008221954,0.0260964682235297,1.5834182641107044,77]
["Q7Z7L1","Schlafen family member 11 [OS=Homo sapiens]",21,12,30,10,901,102.8,7.77,80.77,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SLFN11","ENSG00000172716","","","",2170,2310.2,2273.6,2455.9,2255.5,2785.8,0.900842981379715,-0.15065243138569162,0.19680785227318043,0.7059575780038572,0.4550675711055602,0.34192411195946393,3161]
["Q86TG7-1","Retrotransposon-derived protein PEG10 [OS=Homo sapiens]",22,12,39,4,708,80.1,6.39,131.72,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","PEG10","ENSG00000242265","","","",3643.5,3810,4089.3,1321.2,1361.4,2135.8,2.395566993192761,1.2603671597009487,1.6153780497105879E-3,2.7917258227511716,0.054409208135182886,1.264327594715728,217]
["Q86TU7","Histone-lysine N-methyltransferase setd3 [OS=Homo sapiens]",15,8,12,8,594,67.2,5.96,42.46,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","cytoskeletal activity;other molecular function","SETD3","ENSG00000183576","","PKMTs methylate histone lysines","Histone modifications",1112.3,1137.6,1097.7,1100.7,1092,1005.9,1.0465828800100043,0.06568656467038893,0.20031160535526696,0.6982938884710467,0.45910239057436375,0.33809044583003295,3189]
["Q86U38","Nucleolar protein 9 [OS=Homo sapiens]",16,9,15,9,636,69.4,7.28,32,"RNA metabolism OR transcription;other metabolic processes;transport","nucleus;other cell component","","NOP9","ENSG00000196943; ENSG00000285326","","","",928,930.8,918.8,1059.3,1056.1,1537.4,0.7604029785370128,-0.39516391178022214,0.14221900498982146,0.8470423641498479,0.39584109195377193,0.4024791240193355,2626]
["Q86UD5","Sodium/hydrogen exchanger 9B2 [OS=Homo sapiens]",3,1,1,1,537,57.5,6.71,2.37,"transport;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle","transporter activity;other molecular function","SLC9B2","ENSG00000164038","","Stimuli-sensing channels","",32.6,34.7,29.5,31.7,38.2,54,0.7812752219531881,-0.3560972348660069,0.2542587607878268,0.5947240740148118,0.5119496646276105,0.29077273716695123,3630]
["Q86UF1","Tetraspanin-33 [OS=Homo sapiens]",5,1,2,1,283,31.5,7.17,7.59,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","TSPAN33","ENSG00000158457","","Amyloid fiber formation","",62.3,57.1,51.9,57.5,46.6,26.1,1.315668202764977,0.3957957029183636,0.22997739391978528,0.6383148517145975,0.49020261655284647,0.30962437494556866,3429]
["Q86UV5","Ubiquitin carboxyl-terminal hydrolase 48 [OS=Homo sapiens]",15,11,20,11,1035,119,6.05,67.89,"protein metabolism;other metabolic processes","cytosol;mitochondrion;nucleus","other molecular function","USP48","ENSG00000090686","","Ub-specific processing proteases","",1824.4,1812.1,2001.5,2196.3,2182.8,1684.5,0.9298106735272774,-0.10499110788132497,0.47277839691167445,0.3253423762816255,0.6489271930567941,0.18780402650842784,5325]
["Q86V42","Protein FAM124A [OS=Homo sapiens]",1,1,1,1,546,60.1,6.6,1.79,"","","","FAM124A","ENSG00000150510","","","",308.4,236.1,283.2,282.5,293.6,311.3,0.9327248140635566,-0.10047659574579458,0.4317949869306205,0.36472240406062784,0.6239599761715906,0.20484326718504084,5058]
["Q86V85","Integral membrane protein GPR180 [OS=Homo sapiens]",5,2,3,2,440,49.4,7.39,6.67,"signal transduction;other biological processes","other membranes","","GPR180","ENSG00000152749","","","",146.5,127.1,93.7,108.7,99,951.6,0.31682912102130595,-1.658223149551326,0.4037270778598854,0.393912121605888,0.6098039289270308,0.21480978183053898,4839]
["Q86VQ1","Glucocorticoid-induced transcript 1 protein [OS=Homo sapiens]",20,8,12,8,547,58,9.44,39.59,"","other cell component","","GLCCI1","ENSG00000106415","","","",1347.4,1313.9,1245.2,1477.9,1567,2213.3,0.7429348446236355,-0.42869240291234445,0.12606110203108256,0.8994189005744682,0.375307777900278,0.42561243514948255,2455]
["Q86VX9","Vacuolar fusion protein MON1 homolog A [OS=Homo sapiens]",12,4,4,4,555,62.1,6.3,15.8,"","","","","","","","",148.8,145,138.4,130,142.8,140.6,1.0454765360425742,0.06416068343406031,0.2770646754997936,0.5574188412818005,0.5308167007150698,0.2750554216887269,3815]
["Q86W56","Poly(ADP-ribose) glycohydrolase [OS=Homo sapiens]",17,12,21,12,976,111,6.43,67.22,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","PARG","ENSG00000227345","","POLB-Dependent Long Patch Base Excision Repair","",1120.4,1139.8,1120.1,1229.4,1247.5,1182.3,0.9237811543506778,-0.114376980181413,0.010530485697492292,1.9775515973922715,0.12275489627268128,0.910961176339015,627]
["Q86WN1-1","F-BAR and double SH3 domains protein 1 [OS=Homo sapiens]",9,6,7,6,690,76.9,5.34,16.03,"cell-cell signaling;cell organization and biogenesis","cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","FCHSD1","ENSG00000197948","","","",913.8,972.1,898.6,891.6,933.5,1271.5,0.8992120390105276,-0.15326674382083222,0.4429898302927934,0.35360624375078703,0.6312756228524131,0.19978098093256758,5129]
["Q86WU2","Probable D-lactate dehydrogenase, mitochondrial [OS=Homo sapiens]",3,1,1,1,507,54.8,6.65,3.44,"other metabolic processes","other membranes;mitochondrion","other molecular function","LDHD","ENSG00000166816","Pyruvate metabolism; Metabolic pathways","Mitochondrial protein import","Clear cell renal cell carcinoma pathways",48.7,48,51.8,50.7,55.8,70.2,0.8404074702886248,-0.25083910886348865,0.18954808972991166,0.7222805880454535,0.44849692063319013,0.3482405344629312,3089]
["Q86X95","Corepressor interacting with RBPJ 1 [OS=Homo sapiens]",8,4,5,4,450,52.3,9.86,9.3,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","CIR1","ENSG00000138433","Notch signaling pathway; Epstein-Barr virus infection","","Notch signaling pathway (Netpath)",274.4,269.3,306.9,367,392,259.9,0.8348218667190108,-0.26045970498626736,0.2543894006810753,0.5945009878413045,0.5117897411445029,0.2909084238200462,3633]
["Q86Y07","serine/threonine-protein kinase VRK2 [OS=Homo sapiens]",6,3,5,3,508,58.1,8.84,10.03,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;mitochondrion;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","VRK2","ENSG00000028116","","RAC1 GTPase cycle; RAC3 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOD GTPase cycle","",234.4,266.4,240.5,254.3,270.1,312.7,0.8855572810894755,-0.1753424660909022,0.18574561066912554,0.7310814402037326,0.44380996024211783,0.3528029553044383,3059]
["Q86Y39-1","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [OS=Homo sapiens]",26,2,4,2,141,14.8,8.72,13.78,"cell organization and biogenesis","other membranes;mitochondrion","","NDUFA11","ENSG00000174886; ENSPPAG00000024786; ENSPTRG00000029161","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Nonalcoholic fatty liver disease; Oxidative phosphorylation",239.9,262.6,260.6,321.1,307.5,217.2,0.9022227476944904,-0.1484444337776574,0.45557245129344387,0.34144254581544803,0.6385002965491431,0.1948388966940247,5215]
["Q86YB8","ERO1-like protein beta [OS=Homo sapiens]",11,5,8,3,467,53.5,7.99,22.85,"other biological processes","other membranes;ER/Golgi","other molecular function","ERO1B","ENSG00000086619","Protein processing in endoplasmic reticulum","Insulin processing","",245.1,253.1,277,230.3,251.9,367,0.912859161563825,-0.13153580049029628,0.6009560943117535,0.2211572562745717,0.739085999213294,0.13130502464880822,5943]
["Q86YS6","Ras-related protein Rab-43 [OS=Homo sapiens]",39,7,20,6,212,23.3,5.64,58.4,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","RAB43","ENSG00000172780","","Retrograde transport at the Trans-Golgi-Network; RAB geranylgeranylation","",1691.3,1655.8,1650.3,1512.7,1567.4,1057.6,1.207772433960896,0.2723486505870401,0.15182190797141315,0.8186655550242853,0.40691834446756825,0.3904927310819422,2727]
["Q86YV0","RAS protein activator like-3 [OS=Homo sapiens]",38,35,96,33,1011,111.8,8.75,290.2,"signal transduction;other biological processes","other membranes;cytosol;other cell component","enzyme regulator activity;other molecular function","RASAL3","ENSG00000105122","Ras signaling pathway","Regulation of RAS by GAPs","Ras signaling",10501.2,10620.9,10591.2,11074.1,10704.5,15522.9,0.8501883302280069,-0.2341456383540856,0.2953707110071533,0.529632571578618,0.54475511651559,0.26379868202883466,3963]
["Q8IU85-1","calcium/calmodulin-dependent protein kinase type 1D [OS=Homo sapiens]",29,11,29,8,385,42.9,7.21,95.13,"protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","kinase activity;other molecular function","CAMK1D","ENSCATG00000031901; ENSG00000183049; ENSGGOG00000016547; ENSMMUG00000011956; ENSMNEG00000040028; ENSPPYG00000002093; ENSPTRG00000002296; ENSRBIG00000041279; ENSRROG00000039467","Calcium signaling pathway; Oxytocin signaling pathway; Aldosterone synthesis and secretion; Glioma","","",3356.2,3390.1,3153.2,3671.2,3658.7,3088,0.9502394916441894,-0.07363692895601927,0.4489333906381022,0.34781809156744425,0.6340587733669351,0.1978704838124267,5175]
["Q8IUC8-1","Polypeptide N-acetylgalactosaminyltransferase 13 [OS=Homo sapiens]",3,2,2,1,556,64,6.83,4.33,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","GALNT13","ENSG00000144278; ENSGGOG00000034959; ENSMFAG00000043213; ENSMMUG00000055468; ENSPPAG00000035152; ENSPPYG00000012857; ENSPTRG00000012546","Mucin type O-glycan biosynthesis; Other types of O-glycan biosynthesis; Metabolic pathways","O-linked glycosylation of mucins","",125.9,103.3,137,109.7,130.6,110,1.0453896660005708,0.06404080299527402,0.683741888478697,0.1651078128484036,0.7960289045700536,0.09907116232845424,6278]
["Q8IUR0","Trafficking protein particle complex subunit 5 [OS=Homo sapiens]",32,5,14,5,188,20.8,9.66,29.55,"transport","cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","TRAPPC5","ENSG00000181029","","RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport","",1121.4,1239.4,1215,1397.6,1278.5,743.8,1.0455861282493641,0.06431190619376108,0.8116979642423482,0.0906055432523393,0.8812686305180218,0.05489168867215256,6732]
["Q8IV36","protein HID1 [OS=Homo sapiens]",3,2,2,2,788,88.7,6.06,5.21,"","other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","","HID1","ENSG00000167861","","","",139.1,133.6,147.2,181.7,155,280,0.6808821144802983,-0.5545230581430007,0.16115663950187176,0.7927517972591493,0.4190301949908149,0.37775468098261705,2811]
["Q8IV53-1","DENN domain-containing protein 1C [OS=Homo sapiens]",11,5,11,5,801,87,5.67,41.56,"transport","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity;other molecular function","DENND1C","ENSG00000205744","","RAB GEFs exchange GTP for GDP on RABs","",634.1,649.6,632.9,622.4,643,821.5,0.9183957065503857,-0.12281219737827535,0.4214803649726944,0.3752226525520159,0.6184701842171098,0.20868123240042633,4981]
["Q8IVH4","methylmalonic aciduria type A protein, mitochondrial [OS=Homo sapiens]",10,4,5,4,418,46.5,9.29,14.05,"other metabolic processes","mitochondrion;other cell component","other molecular function","MMAA","ENSG00000151611","","Cobalamin (Cbl, vitamin B12) transport and metabolism; Propionyl-CoA catabolism; Defective MMAA causes MMA, cblA type; Defective MUT causes MMAM","",431,447.9,409.4,393.4,367.8,481.8,1.0364440868865648,0.051642289387733006,0.6986681331978954,0.15572906480622947,0.8057061195240482,0.09382333777653822,6338]
["Q8IW19","Aprataxin and PNK-like factor [OS=Homo sapiens]",5,2,2,2,511,56.9,5.08,6.3,"DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","APLF","ENSG00000169621","","","",100.7,71.1,88.2,46.5,67.9,49,1.591187270501836,0.6701036397701334,0.04201730155331285,1.376571842414046,0.22400033337211056,0.6497513353195858,1371]
["Q8IW50","Protein FAM219A [OS=Homo sapiens]",9,1,2,1,185,20.4,4.73,6.09,"","","","FAM219A","ENSG00000164970","","","",190.8,207.2,218.2,178.8,195.6,109.2,1.274193548387097,0.34958443779022796,0.1847926927308182,0.7333152061106507,0.4434175282894124,0.3531871432267016,3046]
["Q8IWD4-1","Coiled-coil domain-containing protein 117 [OS=Homo sapiens]",11,3,3,3,279,30.5,5.07,4.93,"","","","CCDC117; FLJ33814","ENSG00000159873","","","",177.5,176.6,191.1,258.9,274.9,282.1,0.6682191445030029,-0.5816067783565229,4.0766470877231603E-4,{"$f":"-LOG10(AA4227)","v":3.38969688346773},0.029211974082518213,{"$f":"-LOG10(AC4227)","v":1.5344390933456744},102]
["Q8IWJ2","GRIP and coiled-coil domain-containing protein 2 [OS=Homo sapiens]",30,44,73,43,1684,195.8,5.14,202.13,"cell organization and biogenesis;transport;other biological processes","cytosol;ER/Golgi;nucleus","other molecular function","GCC2","ENSG00000135968","Salmonella infection","Signaling by ALK fusions and activated point mutants; Retrograde transport at the Trans-Golgi-Network","Deregulation of Rab and Rab effector genes in bladder cancer",6587.8,6745,6579.7,7271.3,7332,7336.7,0.9075888787602553,-0.13988916399052065,3.0543242409407004E-4,3.5150848610003855,0.02626359514945362,1.5806458248307054,85]
["Q8IWU5-1","Extracellular sulfatase Sulf-2 [OS=Homo sapiens]",7,5,7,5,870,100.4,9.17,19.82,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","SULF2","ENSG00000196562","","","",459.4,434.3,416.8,518,512.9,668.6,0.7711091497499264,-0.3749930082132545,0.06911951695547155,1.1603993056030384,0.28606712878116736,0.5435320429606152,1766]
["Q8IWY9","Codanin-1 [OS=Homo sapiens]",5,3,5,3,1227,134,6.77,18.73,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","","CDAN1","ENSG00000140326","","","",213.7,264.1,217.7,201.2,174.2,1192.8,0.44350210432342824,-1.1729871450627776,0.43484199054647404,0.36166852488449086,0.6250265700893174,0.20410152025928127,5085]
["Q8IWZ8-1","SURP and G-patch domain-containing protein 1 [OS=Homo sapiens]",9,5,9,5,645,72.4,7.61,25.73,"RNA metabolism OR transcription;other metabolic processes","nucleus","","SUGP1","ENSG00000105705","","mRNA Splicing - Major Pathway","mRNA processing",698.7,684.9,776.1,854.1,739.9,941.6,0.851751064836725,-0.23149624894530943,0.12583596540821612,0.9001952146460377,0.3750958691552413,0.4258577186084421,2452]
["Q8IXH7","Negative elongation factor C/D [OS=Homo sapiens]",25,11,27,11,590,66.2,5.1,83.75,"other biological processes","nucleus","nucleic acid binding activity","NELFCD","ENSG00000101158","","RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat","Initiation of transcription and translation elongation at the HIV-1 LTR",2378.3,2399.8,2345,2418.7,2348.7,1712.3,1.099294720434588,0.13657822405555045,0.3949967187906197,0.4034065120116323,0.6037287782602758,0.21915812190741538,4782]
["Q8IXS8","protein FAM126B [OS=Homo sapiens]",3,2,2,2,530,58.6,7.9,3.57,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol","","FAM126B","ENSG00000155744","","","",151.6,171.8,187.2,157.7,148.1,108.1,1.2336313119110895,0.3029112891768281,0.15392964414647023,0.8126777346228933,0.40986221095320613,0.3873621215250311,2745]
["Q8IXW5","Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 [OS=Homo sapiens]",14,7,8,7,612,69.5,7.78,26.92,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","RPAP2","ENSG00000122484","","RNA polymerase II transcribes snRNA genes","",671.9,713,640.1,836.7,786.7,879.1,0.8091908091908092,-0.3054481610640064,0.009471558854466312,2.023578537767755,0.11674135525682001,0.9327752692480445,593]
["Q8IY63-1","Angiomotin-like protein 1 [OS=Homo sapiens]",1,1,1,1,956,106.5,7.11,0,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","AMOTL1","ENSG00000166025","Tight junction","Signaling by Hippo","",124.5,122.3,132.4,148.7,150.8,161,0.8234527687296418,-0.28024219208043866,0.005153186707307349,2.287924122145103,0.0877963674678541,1.0565234524458544,429]
["Q8IY95","transmembrane protein 192 [OS=Homo sapiens]",12,3,11,3,271,30.9,7.99,29.51,"","other membranes;nucleus;other cytoplasmic organelle;other cell component","other molecular function","TMEM192","ENSG00000170088","","","",1716.2,1660.6,1677.4,1533.9,1651.9,1091,1.1817714178825292,0.2409510116759623,0.20537141504545325,0.6874600045164254,0.4645805238524351,0.3329390006500965,3231]
["Q8IYD1","eukaryotic peptide chain release factor GTP-binding subunit ERF3B [OS=Homo sapiens]",32,17,60,5,628,68.8,5.43,148.61,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;other cell component","nucleic acid binding activity;other molecular function","GSPT2","ENSG00000189369","mRNA surveillance pathway","Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Translation factors",315.4,320.7,304.8,296.8,291.9,319.8,1.035663181067694,0.05055488525277715,0.3317956888234808,0.4791292612662594,0.5720912218945085,0.24253471595050746,4239]
["Q8IYS1","Peptidase M20 domain-containing protein 2 [OS=Homo sapiens]",51,17,62,16,436,47.7,5.85,200.63,"protein metabolism;other biological processes","nucleus","other molecular function","PM20D2","ENSG00000146281","","","",7696.2,7523.6,7450.9,7518.8,7594,8671.3,0.9531872133063685,-0.06916849650985328,0.3832529525443191,0.4165144906972895,0.5975247077957399,0.2236441318233508,4688]
["Q8IYU8","calcium uptake protein 2, mitochondrial [OS=Homo sapiens]",12,4,5,4,434,49.6,9.09,13.56,"transport;other biological processes","other membranes;mitochondrion","other molecular function","MICU2","ENSG00000165487","","Processing of SMDT1","",297.1,307.2,337.2,322.9,277.7,225.7,1.139416676751785,0.18829542707601185,0.2772275309969012,0.5571636428685897,0.5307113735087351,0.27514160504226465,3818]
["Q8IZ81","ELMO domain-containing protein 2 [OS=Homo sapiens]",29,8,34,8,293,34.9,8.05,93.22,"stress response;other biological processes","","enzyme regulator activity","ELMOD2","ENSG00000179387","","","Lung fibrosis",3284.4,3551.3,3502,2962.8,2803.5,1942,1.341112826433844,0.4234306147885362,0.0554450070175274,1.2561375572221178,0.25616154000702135,0.5914860744998026,1582]
["Q8IZN3-1","Probable palmitoyltransferase ZDHHC14 [OS=Homo sapiens]",2,1,1,1,488,53.4,8.24,1.87,"protein metabolism;other metabolic processes;transport","other membranes;ER/Golgi","other molecular function","ZDHHC14","ENSG00000175048; ENSGGOG00000012728; ENSPPYG00000017128","","","",35.4,32.7,26.6,34.8,28.9,36.3,0.9469999999999998,-0.07856366919370229,0.6352021733828432,0.19708802461345212,0.7649847891341575,0.11634720021994625,6069]
["Q8IZT6-1","Abnormal spindle-like microcephaly-associated protein [OS=Homo sapiens]",3,8,10,8,3477,409.5,10.45,29.69,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","other molecular function","ASPM","ENSG00000066279","","","",694,679.9,709.6,638.8,603.1,725.2,1.059173402470642,0.08293879934472724,0.3563715843343057,0.4480969321851056,0.5871776172000542,0.2312305077782551,4436]
["Q8N0X7","Spartin [OS=Homo sapiens]",1,1,1,1,666,72.8,5.91,1.7,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion;other cell component","other molecular function","SPART","ENSG00000133104","Endocytosis","","",91.4,71.4,76.7,101.9,97.9,144.9,0.6948070786190889,-0.5253156427437273,0.09624814323324121,1.0166076399112605,0.33277089824586564,0.477854660998695,2114]
["Q8N0Z8","tRNA pseudouridine synthase-like 1 [OS=Homo sapiens]",10,3,5,3,303,33.2,9.85,13.95,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","PUSL1","ENSG00000169972","","","",335.1,365.1,331.2,293.3,273.7,457.8,1.0064402810304451,0.009261569857570918,0.9722063456427069,0.01224154858896292,0.9833733988794001,0.007281543936993358,7226]
["Q8N141","Zinc finger protein 82 homolog [OS=Homo sapiens]",1,1,1,1,532,62.5,8.98,2.89,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZFP82","ENSG00000181007","Herpes simplex virus 1 infection","","",136.5,157.6,142.1,221.5,210.4,70.4,0.8684053354568985,-0.2035595050310786,0.6764293408611495,0.1697775626684325,0.7910435283766626,0.10179961812853479,6250]
["Q8N1G4","Leucine-rich repeat-containing protein 47 [OS=Homo sapiens]",42,21,77,21,583,63.4,8.28,235.75,"","","other molecular function","LRRC47","ENSG00000130764","","","",7522.8,7877,7980.8,7737.4,7529.8,7690.3,1.018429707067407,0.02634640763327654,0.4066197508979174,0.3908115300323366,0.6107652608534481,0.21412567274316333,4866]
["Q8N1S5-1","zinc transporter zip11 [OS=Homo sapiens]",10,2,4,2,342,35.4,5.6,13.38,"transport","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","transporter activity","SLC39A11","ENSG00000133195","Alzheimer disease; Parkinson disease","","Nuclear receptors meta-pathway; NRF2 pathway; Zinc homeostasis",106.5,102.8,99.7,80.8,81.7,137.4,1.0303434478159388,0.043125315922996864,0.8797764834558953,0.05562765095410439,0.9228309870234126,0.03487783106973821,6968]
["Q8N2K1-1","Ubiquitin-conjugating enzyme E2 J2 [OS=Homo sapiens]",5,1,1,1,259,28.9,8.4,4.48,"protein metabolism;other metabolic processes;stress response","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","UBE2J2","ENSG00000160087","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum; Parkinson disease; Pathways of neurodegeneration","Antigen processing: Ubiquitination & Proteasome degradation; E3 ubiquitin ligases ubiquitinate target proteins","Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway",87,108.1,95.6,128.6,135.8,173.8,{"$f":"AVERAGE(S4354:U4354)/AVERAGE(V4354:X4354)","v":0.6633957097215882},{"$f":"LOG(Y4354,2)","v":-0.5920584128539853},{"$f":"TTEST(V4354:X4354,S4354:U4354,2,2)","v":0.032488360113420905},1.488272209605043,{"$f":"AA4354*7309/AE4354","v":0.20106471132006215},0.6966641453345848,1181]
["Q8N3C0","Activating signal cointegrator 1 complex subunit 3 [OS=Homo sapiens]",22,36,65,36,2202,251.3,7.09,177.2,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","cytosol;nucleus","other molecular function","ASCC3","ENSG00000112249","","ALKBH3 mediated reversal of alkylation damage","Mesodermal commitment pathway; VEGFA-VEGFR2 signaling pathway",6582.2,7213.9,6956.6,7283.3,6674.8,6988.6,0.9907383979338032,-0.013423927310679094,0.8115688373014204,0.09067463739998644,0.8812593421239164,0.05489626607275938,6731]
["Q8N3F8","MICAL-like protein 1 [OS=Homo sapiens]",8,6,7,6,863,93.4,7.25,21.62,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;other cytoplasmic organelle","other molecular function","MICALL1","ENSG00000100139","","","",809.8,772.6,740.3,846,838.7,786.6,0.9398697042042647,-0.08946732759448339,0.14536783364432448,0.8375316816216338,0.39838526288202764,0.3996967354275369,2667]
["Q8N3Z6","Zinc finger CCHC domain-containing protein 7 [OS=Homo sapiens]",9,4,4,4,543,63,7.33,7.63,"","cytosol;nucleus","other molecular function","ZCCHC7","ENSG00000147905","RNA degradation","","",119.4,100.3,86.3,96.9,121.3,182.9,0.7629020194465219,-0.3904303132344951,0.31056928043183996,0.5078415041732602,0.5582761610123753,0.25315091659130706,4066]
["Q8N488","RING1 and YY1-binding protein [OS=Homo sapiens]",30,5,8,5,228,24.8,9.63,24.08,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RYBP","ENSG00000163602","","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Transcriptional Regulation by E2F6","",824.7,737.4,655.1,544,600.8,385.1,1.449245048695993,0.5353015566947508,0.04745831346482004,1.3236876994506794,0.23725910609738007,0.6247771101885481,1462]
["Q8N4Q0","Prostaglandin reductase 3 [OS=Homo sapiens]",11,4,9,4,377,40.1,8.18,24.72,"other metabolic processes;other biological processes","other cytoplasmic organelle","other molecular function","ZADH2","ENSG00000180011","","","",720.7,731.7,660.4,654.7,688.5,809.7,0.9813739607041666,-0.027125102736726206,0.8098689374604604,0.091585258088226,0.8803289803537336,0.05535500097168642,6724]
["Q8N554","Zinc finger protein 276 [OS=Homo sapiens]",2,1,1,1,614,67.2,8.51,1.62,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF276","ENSG00000158805","","","",69.1,77.4,69.4,85.2,80.4,81.3,0.8744430943701903,-0.1935635931202767,0.02877071076738887,1.541049408928515,0.189275540052966,0.7229055059854097,1111]
["Q8N584-1","Tetratricopeptide repeat protein 39C [OS=Homo sapiens]",2,1,1,1,583,65.8,6.99,4.74,"cell organization and biogenesis;developmental processes","","","TTC39C","ENSG00000168234","","","",50.2,61.2,45,59.5,54.5,193.7,0.5082872928176796,-0.9762839310261925,0.3329949831733145,0.4775623094262885,0.5732125134276391,0.24168433737229555,4246]
["Q8N5G2-1","macoilin [OS=Homo sapiens]",10,7,10,7,664,76.1,9.07,24.67,"developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;nucleus;other cell component","cytoskeletal activity","LOC111154705; MACO1","ENSANAG00000024751; ENSCAFG00000012804; ENSCAFG00040000254; ENSCATG00000033846; ENSCCAG00000030283; ENSCPOG00000012618; ENSCSAG00000000952; ENSG00000204178; ENSMMUG00000018014; ENSMNEG00000031369; ENSPANG00000000594; ENSPPAG00000042632; ENSPPYG00000001709; ENSPTRG00000029594","","RHOC GTPase cycle; RHOA GTPase cycle","",1260.8,1271.5,1309.4,1268.5,1476.8,1496,0.9057836040836538,-0.1427616700072753,0.14757024651672718,0.8310011972296131,0.40185951258970154,0.3959257468425946,2684]
["Q8N5U6-1","RING finger protein 10 [OS=Homo sapiens]",5,3,3,3,811,89.9,6.92,6.95,"protein metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","RNF10","ENSG00000022840","","","",175.3,185,175,172.1,184.4,265.3,0.8608877452557092,-0.2161029640260702,0.38250456635959973,0.417363375849085,0.5976327224288829,0.22356563143824634,4678]
["Q8N5X7","Eukaryotic translation initiation factor 4E type 3 [OS=Homo sapiens]",15,3,5,3,224,24.4,6.42,13.8,"protein metabolism;other metabolic processes","cytosol;translational apparatus;other cell component","nucleic acid binding activity","EIF4E3","ENSG00000163412","","ISG15 antiviral mechanism","",719,731.5,696.7,743.5,754,869.7,0.9070631970260222,-0.14072502499373798,0.15340691796524053,0.8141550552085132,0.409514668885297,0.38773053712251143,2738]
["Q8N6H7","ADP-ribosylation factor GTPase-activating protein 2 [OS=Homo sapiens]",28,14,36,14,521,56.7,7.99,94.25,"cell organization and biogenesis;transport","plasma membrane;other membranes;cytosol;ER/Golgi","enzyme regulator activity;other molecular function","ARFGAP2","ENSG00000149182","Endocytosis","COPI-dependent Golgi-to-ER retrograde traffic; CDC42 GTPase cycle; COPI-mediated anterograde transport","IL-18 signaling pathway",5305.2,5587.9,4985.1,6443.8,6159.8,5531.6,0.8755458996867969,-0.19174528228821142,0.07896962369125335,1.102539931496897,0.3060386954185423,0.5142236580142336,1886]
["Q8N6M3","fat storage-inducing transmembrane protein 2 [OS=Homo sapiens]",5,1,2,1,262,29.8,8.65,6.54,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;ER/Golgi","other molecular function","FITM2","ENSG00000197296","","Lipid particle organization","",207.8,265.1,214.4,243.9,233.8,112.4,1.164717844433147,0.2199805010261449,0.5197587856332553,0.2841981609290667,0.6811757152937893,0.16674084353665478,5577]
["Q8N806","Putative E3 ubiquitin-protein ligase UBR7 [OS=Homo sapiens]",21,6,15,6,425,48,4.81,48.09,"protein metabolism;other metabolic processes","other cell component","other molecular function","UBR7","ENSG00000012963; ENSG00000278787","","","",1154.8,1138.5,1191.1,1509,1541.6,1218.8,0.8161334145313159,-0.29312308392876835,0.06524573797461707,1.1854478523354208,0.2759728581345348,0.5591336285943225,1728]
["Q8N8Q9","Magnesium transporter NIPA2 [OS=Homo sapiens]",4,1,1,1,360,39.2,8.22,5.24,"transport","plasma membrane;other membranes;other cytoplasmic organelle","transporter activity","NIPA2","ENSG00000140157","","Miscellaneous transport and binding events","Prader-Willi and Angelman syndrome; 15q11.2 copy number variation syndrome",198.1,195.6,172.6,186.5,190.9,41.4,1.352196752626552,0.43530508755677316,0.37924371160375847,0.42108161169727576,0.5953376907456767,0.2252366214551349,4656]
["Q8N8S7","Protein enabled homolog [OS=Homo sapiens]",12,6,8,6,591,66.5,6.93,18.75,"cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","ENAH","ENSG00000154380","Rap1 signaling pathway; Axon guidance; Regulation of actin cytoskeleton","Generation of second messenger molecules; Signaling by ROBO receptors","Regulation of actin cytoskeleton",953.4,917,906.5,1041.3,1148.5,876.3,0.9056782231499299,-0.1429295262086852,0.29685824065680794,0.5274508907429604,0.5465332193855439,0.2623834356221024,3970]
["Q8N9B5-1","Junction-mediating and -regulatory protein [OS=Homo sapiens]",9,7,7,7,988,111.4,6.18,11.21,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","JMY","ENSG00000152409","","Regulation of TP53 Activity through Methylation","",637.5,619.5,632.6,738.6,730.5,794.9,0.8346289752650177,-0.2607930883220874,0.003987966223969154,2.399248528596574,0.07752139662497486,1.1105784116402624,376]
["Q8N9Q2","protein SREK1IP1 [OS=Homo sapiens]",5,1,1,1,155,18.2,9.85,0,"RNA metabolism OR transcription;other metabolic processes","","nucleic acid binding activity;other molecular function","SREK1IP1","ENSG00000153006","","","",406.4,378.4,337.9,421.7,376.5,11.6,1.3863917016547294,0.47133492428368695,0.4715700577678372,0.3264537781295998,0.6484864632596655,0.1880990851049424,5315]
["Q8N9R8-1","protein SCAI [OS=Homo sapiens]",7,4,6,4,606,70.4,8.6,11.07,"RNA metabolism OR transcription;other metabolic processes;other biological processes","other membranes;nucleus;other cell component","other molecular function","SCAI","ENSANAG00000024288; ENSCSAG00000013617; ENSG00000173611; ENSMMUG00000020633; ENSPPYG00000019606","","RHO GTPases Activate Formins","",529.7,567.7,566.7,569.2,571.3,1094.3,0.7446303919813854,-0.42540359410752043,0.3384554259912555,0.4704985190636294,0.5756971628043022,0.23980591086355962,4297]
["Q8NB14","Ubiquitin carboxyl-terminal hydrolase 38 [OS=Homo sapiens]",5,5,6,4,1042,116.5,6.21,13.72,"protein metabolism;other metabolic processes","cytosol;nucleus","other molecular function","USP38","ENSG00000170185","","","Integrated breast cancer pathway",391.8,385.2,390.9,264.9,284.5,332.3,1.3246002041510716,0.40555698569595067,9.031121326534497E-3,2.0442583232532274,0.11380769961317352,0.9438283549321916,580]
["Q8NB37","Glutamine amidotransferase-like class 1 domain-containing protein 1 [OS=Homo sapiens]",23,4,9,4,220,23.3,6.61,30.33,"","","","GATD1","ENSG00000177225","","","",964.7,1074.9,973.9,1166.8,993.1,1689.2,0.7829102907173104,-0.35308108820362505,0.2594502988922704,0.5859458246522725,0.5167090557503009,0.2867539270203889,3670]
["Q8NBB4","Zinc finger and SCAN domain-containing protein 1 [OS=Homo sapiens]",2,1,1,1,408,45.3,8.54,0,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZSCAN1","ENSG00000152467","","","",133.1,122.9,139.4,92.7,96.9,30.2,1.7989080982711554,0.8471214847799767,0.05704359734467405,1.243793094346961,0.2596087503064898,0.5856806734056502,1606]
["Q8NBJ9-1","SID1 transmembrane family member 2 [OS=Homo sapiens]",5,2,2,2,832,94.4,6.96,5.39,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle","transporter activity;nucleic acid binding activity;other molecular function","SIDT2","ENSG00000149577","","","",30.8,30.9,30.8,34.4,31.3,31.4,0.952626158599382,-0.07001793001551783,0.20634048591966747,0.685415551055263,0.46533249354731554,0.3322366202035,3241]
["Q8NBP0-1","Tetratricopeptide repeat protein 13 [OS=Homo sapiens]",12,8,11,8,860,96.8,7.01,35.48,"","","","TTC13","ENSG00000143643","","","",814.7,817.3,808.1,740.2,713.4,785.3,1.0898655589798565,0.12415018146511309,0.03385735584610955,1.4703469619472165,0.20434633681190315,0.6896331432062958,1211]
["Q8NBS9-1","Thioredoxin domain-containing protein 5 [OS=Homo sapiens]",71,29,1001,28,432,47.6,5.97,2951.38,"transport;other biological processes","non-structural extracellular;ER/Golgi;other cytoplasmic organelle","other molecular function","TXNDC5","ENSG00000239264","Protein processing in endoplasmic reticulum","Golgi Associated Vesicle Biogenesis; Neutrophil degranulation; Lysosome Vesicle Biogenesis","VEGFA-VEGFR2 signaling pathway",104749.3,105157.3,98604.7,111578.6,111130.9,143654.6,0.8420893313509703,-0.2479548080791554,0.15370638146372595,0.8133081014205495,0.4098649916520879,0.38735917507607504,2741]
["Q8NC51-3","Isoform 3 of Plasminogen activator inhibitor 1 RNA-binding protein [OS=Homo sapiens]",46,20,124,3,393,43.1,8.44,368.7,"","","","SERBP1","","","","",15418.1,14782.1,12170.1,15624.2,14111.3,10340.7,1.0572434512254159,0.08030762405659177,0.7018837781959031,0.15373479480308386,0.8076304368441208,0.09278732233815075,6352]
["Q8NC56-1","LEM domain-containing protein 2 [OS=Homo sapiens]",29,15,39,15,503,56.9,9,105.47,"cell organization and biogenesis;developmental processes;other biological processes","other membranes;nucleus","nucleic acid binding activity","LEMD2","ENSG00000161904","","Sealing of the nuclear envelope (NE) by ESCRT-III; Initiation of Nuclear Envelope (NE) Reformation; Depolymerisation of the Nuclear Lamina","",3373.4,3211.6,3144.9,2833.9,2963.2,4367.1,0.9572716003227011,-0.06299978580110871,0.7847322860321018,0.1052784789606235,0.8627569612828868,0.06411152785270513,6648]
["Q8NCG7","Sn1-specific diacylglycerol lipase beta [OS=Homo sapiens]",17,8,18,8,672,73.7,6.55,51.15,"cell-cell signaling;cell cycle OR cell proliferation;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;nucleus","other molecular function","DAGLB","ENSG00000164535","Retrograde endocannabinoid signaling; Aldosterone synthesis and secretion","Arachidonate production from DAG","Cannabinoid receptor signaling",1405,1407,1397.3,1325.2,1254.2,1799.3,0.9613127183867359,-0.0569222737985731,0.757976967189701,0.12034399116794126,0.8446491314513682,0.07332366018600342,6559]
["Q8NCL4","Polypeptide N-acetylgalactosaminyltransferase 6 [OS=Homo sapiens]",4,3,4,2,622,71.1,8.18,13.51,"protein metabolism;other metabolic processes","other membranes;ER/Golgi;other cell component","other molecular function","GALNT6","ENSG00000139629","Mucin type O-glycan biosynthesis; Other types of O-glycan biosynthesis; Metabolic pathways","O-linked glycosylation of mucins","",150.2,169.2,138.3,194.7,174.3,162.2,0.8616340361445781,-0.2148528547462634,0.13419367077362668,0.8722679671246258,0.38615021247418796,0.4132437218605909,2540]
["Q8ND24","Ring finger protein 214 [OS=Homo sapiens]",8,5,7,5,703,77.6,6.95,19.94,"protein metabolism;other metabolic processes","","other molecular function","RNF214","ENSG00000167257","","","",659,682.5,673.9,746.3,744.3,635.3,0.9480220142057484,-0.0770075342694088,0.3794002373091264,0.4209024018026228,0.595327680225935,0.2252439241173117,4658]
["Q8NDA8-1","Maestro heat-like repeat-containing protein family member 1 [OS=Homo sapiens]",8,15,27,15,1641,181.1,6.89,49.58,"","","","MROH1","ENSG00000179832","","","",2469.8,2483.3,2398.2,2340.3,2354.7,2622.5,1.00461906388794,6.648557302983419E-3,0.9117598883259734,0.04011951792685657,0.9424484547835582,0.02574239328686979,7071]
["Q8NDX6","Zinc finger protein 740 [OS=Homo sapiens]",4,1,2,1,193,21.8,9.19,3.54,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ZNF740","ENSG00000139651","","Generic Transcription Pathway","",98.7,80.2,92.5,99,93.1,330.9,0.5189292543021031,-0.94639022571545,0.34549102481009963,0.46156323027553375,0.5793057812197793,0.23709213740924484,4359]
["Q8NE01","Metal transporter CNNM3 [OS=Homo sapiens]",13,8,8,8,707,76.1,6.09,19.59,"transport","plasma membrane;other membranes;other cell component","transporter activity","CNNM3","ENSG00000168763","","","",563,543,542.8,543.6,521.7,654.3,0.9588276343335659,-0.06065660544404565,0.6006871324310915,0.2213516711557359,0.7391283250738802,0.13128015425295644,5940]
["Q8NEL9-1","Phospholipase DDHD1 [OS=Homo sapiens]",7,5,6,5,900,100.4,5.67,14.26,"other metabolic processes;other biological processes","cytosol;other cell component","other molecular function","DDHD1","ENSG00000100523","","Synthesis of PA","",567,520,544.1,548.3,555.8,599.5,0.9574430617515848,-0.06274140103107988,0.3129603952748999,0.5045106183699994,0.5600948895847804,0.2517383899008992,4084]
["Q8NEM2","SHC SH2 domain-binding protein 1 [OS=Homo sapiens]",28,14,44,14,672,75.6,4.75,139.46,"signal transduction;other biological processes","cytoskeleton;other cell component","","SHCBP1","ENSG00000171241","","","",2737.4,2822,2746.6,3476.2,3515.3,3259.1,0.8102940315688837,-0.30348258082517,1.5230876802387933E-3,2.817275094728434,0.05352042237916029,1.2714804678072222,208]
["Q8NEZ2","Vacuolar protein sorting-associated protein 37A [OS=Homo sapiens]",7,2,2,2,397,44.3,5.57,7.15,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","","VPS37A","ENSG00000155975","Endocytosis","Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; HCMV Late Events","7q11.23 copy number variation syndrome",325.6,334.5,317.1,376.4,363.8,420.9,0.8416157092412369,-0.2487664612731734,0.02729605904904271,1.5639000510106047,0.18680420935342057,0.7286133418191694,1068]
["Q8NF37","Lysophosphatidylcholine acyltransferase 1 [OS=Homo sapiens]",32,12,41,12,534,59.1,6.02,121.9,"other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","LPCAT1","ENSG00000153395","Glycerophospholipid metabolism; Ether lipid metabolism; Metabolic pathways","Neutrophil degranulation; Synthesis of PA; Acyl chain remodelling of PC; Acyl chain remodelling of PG; Synthesis of PC","",4233.9,4313.6,4147.7,4152.9,4147,5165.7,0.9427875475285172,-0.08499539149391216,0.4944381892805636,0.30588799270627315,0.6647992504510006,0.17730947888275686,5436]
["Q8NFG4-1","Folliculin [OS=Homo sapiens]",7,3,3,3,579,64.4,6.23,7.92,"cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","FLCN","ENSG00000154803","mTOR signaling pathway; Renal cell carcinoma","Amino acids regulate mTORC1","Ciliopathies",341.5,375.7,363.6,364.2,320.1,150.7,1.2943712574850301,0.3722514770769078,0.281275817241786,0.5508676048056894,0.5331548102230845,0.2731466681525097,3856]
["Q8NFT6-1","Protein DBF4 homolog B [OS=Homo sapiens]",1,1,1,1,615,67.2,8.34,0,"cell cycle OR cell proliferation;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","DBF4B","ENSG00000161692","","","",645.4,636.5,558.7,610.3,596.5,1108,0.7951442889234492,-0.33071141558961076,0.4063244955592449,0.39112699513473426,0.6106982804940408,0.21417330281893868,4863]
["Q8NG11-1","Tetraspanin-14 [OS=Homo sapiens]",8,2,2,2,270,30.7,6.84,5.39,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","TSPAN14","ENSCATG00000031568; ENSCSAG00000009464; ENSG00000108219; ENSGGOG00000005770; ENSMMUG00000013895; ENSMNEG00000032257; ENSNLEG00000029109; ENSPPAG00000030989; ENSPTRG00000002686","","Neutrophil degranulation; Amyloid fiber formation","",108.4,141.2,126.7,140.5,135.4,230.6,0.7429417571569595,-0.42867897962061924,0.2507355873115927,0.6007840215416024,0.5087802353304917,0.29346976814114395,3602]
["Q8NH93","Olfactory receptor 1L3 [OS=Homo sapiens]",2,1,1,1,324,36.6,9.2,2.06,"signal transduction;other biological processes","plasma membrane;other membranes","other molecular function","OR1L3","ENSG00000171481","Olfactory transduction","","",43,51.8,57.1,60.4,44.1,17.7,1.2430441898527005,0.3138775846833539,0.49196186365628525,0.3080685619594047,0.6626887691603002,0.17869038950100902,5426]
["Q8NHU6","tudor domain-containing protein 7 [OS=Homo sapiens]",4,5,5,5,1098,123.5,7.21,9.53,"developmental processes;other biological processes","mitochondrion;other cell component","nucleic acid binding activity;other molecular function","TDRD7","ENSG00000196116","","","",657.4,677.2,667.8,693,675.6,463.3,1.0930727659806756,0.12838944458269272,0.4856303666615507,0.31369416447561405,0.6574314409944941,0.1821495300628836,5399]
["Q8NHV4","Protein NEDD1 [OS=Homo sapiens]",13,8,15,8,660,71.9,7.97,41.05,"cell cycle OR cell proliferation;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus","","NEDD1","ENSG00000139350","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2","",1469.1,1425.9,1423.5,1555.1,1610.2,1315,0.9638863468964132,-0.05306504846875909,0.5885299957558028,0.2302313974607418,0.7304407775478285,0.13641498989643752,5889]
["Q8NI60-1","Atypical kinase COQ8A, mitochondrial [OS=Homo sapiens]",9,6,15,6,647,71.9,6.99,44.09,"protein metabolism;other metabolic processes","other membranes;mitochondrion","kinase activity;other molecular function","COQ8A","ENSG00000163050","","","",1870,1816.5,1813.2,1892.7,1876.7,1911.7,0.9680695639928887,-0.04681737381142418,0.04506965242381653,1.346115791185747,0.23214523577566953,0.6342402247592482,1419]
["Q8TAF3-1","WD repeat-containing protein 48 [OS=Homo sapiens]",22,11,23,11,677,76.2,7.03,55.85,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","WDR48","ENSANAG00000001805; ENSCAFG00000005066; ENSCANG00000036746; ENSCATG00000045029; ENSCCAG00000035592; ENSCSAG00000014688; ENSFCAG00000025123; ENSG00000114742; ENSGGOG00000002185; ENSLCNG00005009903; ENSMLEG00000040913; ENSMMUG00000020138; ENSMNEG00000033674; ENSNLEG00000005481; ENSPANG00000006231; ENSPPAG00000029758; ENSPTRG00000014765; ENSRROG00000029632; ENSSSCG00070011863; ENSSTOG00000011459","Fanconi anemia pathway","Fanconi Anemia Pathway; Ub-specific processing proteases; Recognition of DNA damage by PCNA-containing replication complex; Ub-specific processing proteases; Fanconi Anemia Pathway; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins; Recognition of DNA damage by PCNA-containing replication complex","DNA repair pathways, full network",2029.4,2029.2,2099.6,2458.9,2422.6,3523.8,0.732656776081758,-0.44879059013116274,0.10728315978028453,0.9694684438166664,0.34757651366759734,0.45894957724399815,2256]
["Q8TAQ2","SWI/SNF complex subunit SMARCC2 [OS=Homo sapiens]",38,52,186,1,1214,132.8,5.69,556.76,"cell organization and biogenesis;developmental processes;other biological processes","nucleus","other molecular function","SMARCC2","ENSG00000139613","Thermogenesis; Hepatocellular carcinoma","RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","Tumor suppressor activity of SMARCB1; Thermogenesis",21690.1,21589.2,21355.9,24004,25466.4,19261.1,0.9404014171086039,-0.08865138187046583,0.5069235279555869,0.295057551301452,0.6730434270349474,0.1719569127252496,5505]
["Q8TB36","ganglioside-induced differentiation-associated protein 1 [OS=Homo sapiens]",10,3,4,3,358,41.3,8.34,12.93,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;mitochondrion;other cytoplasmic organelle","","GDAP1","ENSG00000104381","","Class I peroxisomal membrane protein import","Intracellular trafficking proteins involved in CMT neuropathy",132.5,132.8,133.5,126.8,114.8,241.2,0.8260149130074567,-0.27576026635682527,0.5252746098422303,0.2796135911479873,0.6850878164412672,0.16425375587775135,5604]
["Q8TBQ9","Protein kish-A [OS=Homo sapiens]",13,1,11,1,72,8.1,8.95,25.22,"transport","other membranes;ER/Golgi","","TMEM167A","ENSG00000174695","","","",1439.4,1292.8,1686.5,1177.1,1177.3,359.7,1.628053498397259,0.7031481078377569,0.12706981940036105,0.8959575873242518,0.3757092677982358,0.425148091857057,2472]
["Q8TBZ6","tRNA methyltransferase 10 homolog A [OS=Homo sapiens]",8,3,3,3,339,39.7,7.65,5.15,"RNA metabolism OR transcription;other metabolic processes","cytosol;cytoskeleton;mitochondrion;nucleus","nucleic acid binding activity;other molecular function","TRMT10A","ENSG00000145331","","tRNA modification in the nucleus and cytosol","",274.4,247.8,287.9,354.6,400.9,129.6,0.9152638119986443,-0.12774045487259716,0.7823442251486138,0.10660211882066932,0.8610380878800208,0.06497763717554045,6641]
["Q8TCG2","Phosphatidylinositol 4-kinase type 2-beta [OS=Homo sapiens]",11,6,9,5,481,54.7,5.97,19.27,"cell organization and biogenesis;other metabolic processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","kinase activity;other molecular function","PI4K2B","ENSG00000038210","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the ER membrane","",587.5,551.7,559.1,622.5,657.6,1155.8,0.6971961082146231,-0.5203635786009504,0.22733203174975786,0.6433393665977118,0.48754982982951295,0.31198099080840147,3408]
["Q8TCJ2","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [OS=Homo sapiens]",19,19,81,18,826,93.6,8.91,215.66,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi;other cell component","other molecular function","STT3B","ENSG00000163527","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum","","",11573.2,10830,11633,9802.7,10199.8,7285.3,1.2473046562932886,0.318813888937935,0.07666414661274353,1.1154076943129478,0.302558449024051,0.5191907147748904,1852]
["Q8TD16","Protein bicaudal D homolog 2 [OS=Homo sapiens]",42,30,63,27,824,93.5,5.44,201,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","BICD2","ENSG00000185963","","COPI-independent Golgi-to-ER retrograde traffic","",5540.6,5792.2,5561.2,6466.3,6359.7,6190,0.8884097602019351,-0.17070285225282714,3.4231264583205116E-3,2.4655770567089426,0.07358715083489593,1.1331980118672247,340]
["Q8TDB6-1","E3 ubiquitin-protein ligase DTX3L [OS=Homo sapiens]",1,1,1,1,740,83.5,8.06,2.45,"protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","DTX3L","ENSG00000163840","Notch signaling pathway","Antigen processing: Ubiquitination & Proteasome degradation","Notch signaling",62.5,64.5,75.6,128.3,117.4,140.9,0.5240558717020175,-0.9322074634100977,1.496749181688059E-3,2.8248509706223697,0.05310553285901953,1.27486022910755,206]
["Q8TDI8","Transmembrane channel-like protein 1 [OS=Homo sapiens]",1,1,2,1,760,87.7,6.52,3.9,"transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","transporter activity","TMC1","ENSG00000165091","","Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea","",425.4,469.3,346,314.8,302.2,73.1,{"$f":"AVERAGE(S4674:U4674)/AVERAGE(V4674:X4674)","v":1.797855383277786},{"$f":"LOG(Y4674,2)","v":0.8462769773490255},{"$f":"TTEST(V4674:X4674,S4674:U4674,2,2)","v":0.10097709557039873},0.995777125182317,{"$f":"AA4674*7309/AE4674","v":0.3396417816493531},0.4689788896188686,2173]
["Q8TDY2-1","RB1-inducible coiled-coil protein 1 [OS=Homo sapiens]",17,26,40,26,1594,183,5.41,90.54,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RB1CC1","ENSG00000023287","Autophagy; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration","Macroautophagy","Alzheimer's disease and miRNA effects; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Malignant pleural mesothelioma; Alzheimer's disease; Senescence and autophagy in cancer",3628.8,3750.3,3682.3,3691.5,3444.4,4135.3,0.9813861878060899,-0.02710712807046576,0.7503478188309759,0.12473737556414069,0.8403757597051185,0.07552648313202381,6526]
["Q8TEA8","D-aminoacyl-tRNA deacylase 1 [OS=Homo sapiens]",35,6,23,6,209,23.4,8.24,66.76,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DTD1","ENSG00000125821","","","",2529.7,2594.7,2608.6,2712.2,2318.4,1590.5,1.1679328208303756,0.22395729318865526,0.3235352202895281,0.4900784347949809,0.5672149016781388,0.24625236803730535,4169]
["Q8TED0","U3 small nucleolar RNA-associated protein 15 homolog [OS=Homo sapiens]",21,12,22,12,518,58.4,9.11,54.87,"RNA metabolism OR transcription;other metabolic processes;other biological processes","ER/Golgi;nucleus;other cell component","","UTP15","ENSG00000164338","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",2646.5,2683.3,2637.4,3149.9,3011.4,4193.2,0.7694432372398475,-0.37811319377002633,0.0999917014239925,1.000036041753174,0.33788226801107774,0.4712345993082925,2163]
["Q8TET4","neutral alpha-glucosidase c [OS=Homo sapiens]",5,2,2,2,914,104.3,6.23,6.3,"protein metabolism;other metabolic processes","","other molecular function","GANC","ENSG00000214013","Galactose metabolism; Starch and sucrose metabolism; Metabolic pathways","","",30.4,50.4,36.9,50.7,42,50.9,0.8196378830083564,-0.28694142878460743,0.25975755190469463,0.585431817388262,0.5171800454566639,0.2863582400082758,3671]
["Q8TEU7","Rap guanine nucleotide exchange factor 6 [OS=Homo sapiens]",12,16,23,14,1601,179.3,6.4,67.06,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","RAPGEF6","ENSG00000158987","Rap1 signaling pathway; Tight junction","","",1522.7,1579.8,1477.3,1735.6,1729.3,4314.7,0.5886935060928583,-0.764411381589177,0.2832747602797521,0.547792119300764,0.5352779790291387,0.2714206228277551,3868]
["Q8TF30","WASP homolog-associated protein with actin, membranes and microtubules [OS=Homo sapiens]",3,2,3,2,809,90.9,7.08,12.4,"cell adhesion;cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","WHAMM","ENSG00000156232","Tight junction","RHOD GTPase cycle","",175.5,197.7,202.6,128,130.1,230.8,1.1777459603190834,0.23602838355529693,0.45358712995872896,0.343339276573707,0.6370615551245868,0.19581860257928269,5204]
["Q8WTS6","Histone-lysine N-methyltransferase SETD7 [OS=Homo sapiens]",34,10,22,10,366,40.7,4.63,70.13,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","other molecular function","SETD7","ENSG00000145391","Lysine degradation; Metabolic pathways; FoxO signaling pathway","PKMTs methylate histone lysines","Histone modifications",2236.3,2217.9,2130.3,2499.9,2585,2431.2,0.8760527401178805,-0.19091036933470995,0.004913203972162696,2.3086352057113193,0.08653158513864373,1.062825340539439,415]
["Q8WTW4","GATOR complex protein NPRL2 [OS=Homo sapiens]",10,3,4,3,380,43.6,6.52,11.64,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;other cytoplasmic organelle;other cell component","enzyme regulator activity;kinase activity","NPRL2","ENSG00000114388","mTOR signaling pathway","Amino acids regulate mTORC1","22q11.2 copy number variation syndrome",308.2,284.9,286.7,327.7,343.9,245.6,0.9592237243785435,-0.06006075367066936,0.7110609479782171,0.14809317249640708,0.813961545618291,0.08939611221186822,6385]
["Q8WUA4-1","General transcription factor 3C polypeptide 2 [OS=Homo sapiens]",14,9,12,9,911,100.6,7.31,32.67,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","GTF3C2","ENSG00000115207; ENSPPAG00000042866; ENSPTRG00000011763","","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter","",1373.5,1469.7,1325.3,1673.2,1636.9,2452.1,0.7234216098018117,-0.4670914005593387,0.11976228966942874,0.9216799095479983,0.3673279795190326,0.43494599001048134,2383]
["Q8WUF8","Protein Fam172a [OS=Homo sapiens]",11,4,5,4,416,47.9,6.09,13.07,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","ER/Golgi;nucleus","","FAM172A","ENSG00000113391","","","",205.6,228.4,224.5,233.4,226.8,204.9,0.9900766801984663,-0.014387830444586754,0.852878165155679,0.06911300397867075,0.9069818869668062,0.042401386003757695,6873]
["Q8WUM0","Nuclear pore complex protein Nup133 [OS=Homo sapiens]",39,35,105,35,1156,128.9,5.1,328.44,"cell organization and biogenesis;other metabolic processes;transport;developmental processes","other membranes;cytosol;nucleus;other cell component","other molecular function","NUP133","ENSG00000069248","Nucleocytoplasmic transport; Amyotrophic lateral sclerosis","Separation of Sister Chromatids; Transport of Mature mRNA derived from an Intron-Containing Transcript; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; ISG15 antiviral mechanism; Transcriptional regulation by small RNAs; tRNA processing in the nucleus; Viral Messenger RNA Synthesis; Regulation of HSF1-mediated heat shock response; snRNP Assembly; SUMOylation of DNA replication proteins; HCMV Early Events; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Postmitotic nuclear pore complex (NPC) reformation","Ciliary landscape",9482.4,9245.6,9834.2,8540,8584.7,5453.8,1.2650176052439268,0.33915746303924327,0.13037604101488032,0.8848022108360695,0.38086270334842537,0.41923155430949766,2502]
["Q8WUX1-1","Sodium-coupled neutral amino acid transporter 5 [OS=Homo sapiens]",10,5,11,5,472,51.4,8.21,26.74,"transport","plasma membrane;other membranes","transporter activity","SLC38A5","ENSG00000017483","GABAergic synapse","Amino acid transport across the plasma membrane","Neuroinflammation and glutamatergic signaling",1385.4,1307.2,1374.2,1629.2,1621.1,1907.1,0.7885368596579674,-0.34274990042595777,0.020073697111555378,1.6973726331289598,0.16229939401367063,0.7896831017203502,904]
["Q8WUY1","Protein THEM6 [OS=Homo sapiens]",26,5,8,5,208,23.9,9.55,20.98,"","non-structural extracellular","","THEM6","ENSG00000130193","","","",1128.8,1061.4,1051.2,875.1,1031.3,2520.2,0.7322550038404191,-0.44958194814005376,0.4934843025046188,0.30672665747063765,0.664005295840622,0.17782845685910997,5432]
["Q8WVB3","Hexosaminidase D [OS=Homo sapiens]",14,4,7,4,486,53.8,5.97,9.2,"other metabolic processes","non-structural extracellular;nucleus;other cell component","other molecular function","HEXD","ENSG00000169660","Other glycan degradation; Various types of N-glycan biosynthesis; Metabolic pathways","","",483.1,456.8,444.5,439.9,476.2,855.8,0.7813082002370337,-0.35603633878085394,0.38800963279698614,0.4111574923989728,0.6012216252094915,0.2209654067607017,4717]
["Q8WVM0","Dimethyladenosine transferase 1, mitochondrial [OS=Homo sapiens]",10,3,5,3,346,39.5,9.26,9.47,"RNA metabolism OR transcription;other metabolic processes","mitochondrion","nucleic acid binding activity;other molecular function","TFB1M","ENSG00000029639","","Transcriptional activation of mitochondrial biogenesis; rRNA modification in the mitochondrion","Energy metabolism; Mitochondrial gene expression",621.4,559.3,576.8,600.9,629.5,1067.6,0.7647954743255003,-0.3868541086862159,0.301923575762057,0.5201029736824097,0.5521039317600387,0.2579791600585415,3997]
["Q8WVP7-1","Limb region 1 protein homolog [OS=Homo sapiens]",4,2,3,2,490,55.1,5.94,7.03,"developmental processes;signal transduction","plasma membrane;other membranes","other molecular function","LMBR1","ENSG00000105983; ENSPPYG00000018221","","","",151.6,184.4,170.2,154.2,152.3,625.6,0.5430747773844008,-0.8807772347323128,0.4189957087602003,0.37779042493659026,0.6179256729879549,0.20906376075664312,4956]
["Q8WW59","SPRY domain-containing protein 4 [OS=Homo sapiens]",27,4,9,4,207,23.1,6.93,24.78,"","nucleus","","SPRYD4","ENSG00000176422","","","",747.1,897.6,902.2,718.1,629.7,508.7,1.371882574737409,0.45615700039263507,0.04393560732407283,1.357183365947127,0.22986782672272607,0.6385218101773359,1397]
["Q8WWM7-1","ataxin-2-like protein [OS=Homo sapiens]",32,28,81,27,1075,113.3,8.59,230.61,"cell organization and biogenesis;other biological processes","other membranes;cytosol;nucleus;other cell component","","ATXN2L","ENSG00000168488","Amyotrophic lateral sclerosis; Spinocerebellar ataxia; Pathways of neurodegeneration","","16p11.2 distal deletion syndrome",9794.3,9733.1,10415.1,14436.5,13757.8,15680.9,0.6824470315804829,-0.5512110199049297,1.536641535871976E-3,2.813427431881884,0.052977891441925815,1.2759053309266626,212]
["Q8WWW0-2","Isoform 2 of Ras association domain-containing protein 5 [OS=Homo sapiens]",20,5,16,5,265,30.3,8.09,42.51,"","","","RASSF5","","","","",1636.2,1379.9,1579.3,1937.3,2150.7,1407,0.8362875341219291,-0.2579290368745244,0.2698709118543611,0.5688439235277079,0.5244579884986772,0.2802892950661341,3761]
["Q8WXB1-1","Protein N-lysine methyltransferase METTL21A [OS=Homo sapiens]",4,1,1,1,218,24.6,6.27,2.67,"protein metabolism;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","METTL21A","ENSG00000144401","","Protein methylation","",68.6,74.1,58.8,62.5,73.6,98.9,0.8574468085106384,-0.22188091803703225,0.39257802412226317,0.4060740151526197,0.6030585914900424,0.21964049096989416,4758]
["Q8WXE9-1","Stonin-2 [OS=Homo sapiens]",7,4,6,4,905,101.1,5.39,16.32,"transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","STON2","ENSG00000140022","","Cargo recognition for clathrin-mediated endocytosis","",382.5,411.4,404.7,504.1,466.4,581.2,0.7724431268930849,-0.37249938008371364,0.0279661311884118,1.5533676094145974,0.18718356488654014,0.7277322858993429,1092]
["Q8WXX7-1","Autism susceptibility gene 2 protein [OS=Homo sapiens]",1,1,1,1,1259,138.9,9.38,2.35,"cell organization and biogenesis;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","AUTS2","ENSG00000158321","","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","",58.5,78.9,60.4,83.8,76.7,669.2,0.23839942147764254,-2.0685473600619058,0.34397955056456725,0.4634673752800668,0.578763014520355,0.2374992299768844,4344]
["Q8WYP5","protein elys [OS=Homo sapiens]",23,37,83,37,2266,252.3,6.6,286.37,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity","AHCTF1","ENSG00000153207","Nucleocytoplasmic transport","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation","Gastric cancer network 2",6770,7047.5,6683,7453.9,7415.2,9060.2,0.8567112284939384,-0.22311909757999143,0.107634860903596,0.9680470460856399,0.34794480245218184,0.4584896465470267,2261]
["Q8WZ42","Titin [OS=Homo sapiens]",0,7,16,3,34350,3813.7,6.35,25.83,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","non-structural extracellular;cytosol;cytoskeleton;nucleus","cytoskeletal activity;kinase activity;other molecular function","TTN","ENSG00000155657","Hypertrophic cardiomyopathy; Dilated cardiomyopathy","Platelet degranulation ; Striated Muscle Contraction","Striated muscle contraction pathway",1641.5,1686.3,1610.4,1534.8,1489.4,794.2,1.2932641944269854,0.3710170261575881,0.1958536055869613,0.7080684288538863,0.4542983190209775,0.342658870143913,3151]
["Q92187-1","CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase [OS=Homo sapiens]",7,2,2,2,359,41.3,9.74,6.59,"protein metabolism;other metabolic processes;developmental processes","other membranes;ER/Golgi","other molecular function","ST8SIA4","ENSANAG00000034757; ENSCCAG00000025138; ENSG00000113532; ENSGGOG00000011260; ENSNLEG00000035472; ENSPPAG00000033695; ENSPPYG00000015661; ENSPTRG00000042921","","Sialic acid metabolism; NCAM1 interactions","Ectoderm differentiation",86.6,79.8,81.3,91.3,96.3,431.4,0.40016155088852984,-1.3213455408552641,0.3332591020235419,0.4772179802348353,0.5735320877537246,0.24144227934154178,4247]
["Q92508","Piezo-type mechanosensitive ion channel component 1 [OS=Homo sapiens]",11,19,33,19,2521,286.6,7.47,120.25,"transport;other biological processes","plasma membrane;other membranes;ER/Golgi","transporter activity","PIEZO1","ENSG00000103335","","","",2150.5,2131.5,2069.9,1730.6,1839.7,2975.8,0.9703334810039564,-0.043447441703288084,0.8789455015033195,0.056038052264268674,0.922753902684252,0.034914109328565306,6962]
["Q92522","Histone H1x [OS=Homo sapiens]",54,15,108,15,213,22.5,10.76,339.77,"cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity","H1-10","ENSG00000184897","","","",19221.9,16911.1,15894.9,11792.9,12834.8,16936.8,1.2517388636937772,0.3239336202986565,0.13295484362345902,0.8762958364397985,0.3840976095035028,0.4155583957316434,2530]
["Q92544","Transmembrane 9 superfamily member 4 [OS=Homo sapiens]",20,12,30,12,642,74.5,6.54,95.66,"cell adhesion;cell organization and biogenesis;stress response;transport;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle","","TM9SF4","ENSG00000101337","","","",2777.8,3029.1,2994.7,2820.1,2629.9,2889.2,1.0554489639293936,0.0778568190771932,0.23533281845045587,0.6283175038564017,0.49440861456004076,0.30591397072001775,3479]
["Q92551","Inositol hexakisphosphate kinase 1 [OS=Homo sapiens]",7,2,2,2,441,50.2,7.24,4.45,"other metabolic processes;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","IP6K1","ENSG00000176095","Phosphatidylinositol signaling system","Synthesis of pyrophosphates in the cytosol; Synthesis of IPs in the nucleus","",280,240.8,236.7,253.9,290.2,124.1,1.1336426219694702,0.1809659059127053,0.5995038166494777,0.22220804768684854,0.7385426252976628,0.13162443414032932,5933]
["Q92576-1","PHD finger protein 3 [OS=Homo sapiens]",11,13,21,13,2039,229.3,6.96,77.84,"RNA metabolism OR transcription;other metabolic processes;developmental processes","","other molecular function","PHF3","ENSG00000118482","","","",1459.8,1498,1397.4,2066.4,2126.5,3624.3,0.5571304303331117,-0.843912977076859,0.08659648491328834,1.062499736316892,0.31726000412592703,0.498584674455686,1995]
["Q92609-1","TBC1 domain family member 5 [OS=Homo sapiens]",28,15,26,15,795,88.9,6.54,79.85,"other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","enzyme regulator activity;other molecular function","TBC1D5","ENSG00000131374","","","",883.4,913.7,790.2,890.1,890.9,900.7,0.964798448745199,-0.05170050729012711,0.4465706012925965,0.35010987086747763,0.6329231190319154,0.19864904039021955,5157]
["Q92613","protein jade-3 [OS=Homo sapiens]",5,4,4,4,823,93.7,7.18,7.19,"protein metabolism;other metabolic processes","nucleus","other molecular function","JADE3","ENSG00000102221","","HATs acetylate histones","",175.6,202.2,182,216.1,211.7,575.8,0.5577919489836589,-0.8422009838362574,0.2882720999118722,0.5401973882765775,0.5390076178705229,0.26840509682485164,3909]
["Q92622-1","Run domain Beclin-1-interacting and cysteine-rich domain-containing protein [OS=Homo sapiens]",7,5,8,5,972,108.6,6.25,16.64,"other metabolic processes;transport;other biological processes","cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RUBCN","ENSG00000145016","Autophagy","","",773.8,761.4,736.1,813,733.9,1170,0.8359895469100812,-0.2584431917143028,0.331720900304274,0.4792271645948905,0.572097229901826,0.24253015508569334,4238]
["Q92696","geranylgeranyl transferase type-2 subunit alpha [OS=Homo sapiens]",30,14,42,14,567,65,5.67,113.42,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","RABGGTA","ENSG00000100949; ENSG00000285193","","RAB geranylgeranylation; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain","",4182.6,4344.1,4445.7,4336.4,4057.9,6456.2,0.8735328776808863,-0.19506609114482695,0.4570104573964249,0.3400738622111098,0.6389229979170753,0.1945514792356435,5228]
["Q92747","Actin-related protein 2/3 complex subunit 1A [OS=Homo sapiens]",19,6,19,5,370,41.5,8.18,61.41,"cell organization and biogenesis","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity","ARPC1A","ENSG00000241685","Endocytosis; Tight junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection","Clathrin-mediated endocytosis; FCGR3A-mediated phagocytosis; EPHB-mediated forward signaling; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs","Pathogenic Escherichia coli infection",2530.2,2622.8,2499.2,2208.8,2134.5,2058.3,1.195357410647338,0.2574420470542967,0.001877913759099759,2.7263243560566432,0.05719029860525057,1.2426776358842766,240]
["Q92793-1","CREB-binding protein [OS=Homo sapiens]",8,15,27,8,2442,265.2,8.53,70.88,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CREBBP","ENSG00000005339","cAMP signaling pathway; HIF-1 signaling pathway; FoxO signaling pathway; Cell cycle; Wnt signaling pathway; Notch signaling pathway; TGF-beta signaling pathway; Adherens junction; JAK-STAT signaling pathway; Long-term potentiation; Melanogenesis; Thyroid hormone signaling pathway; Glucagon signaling pathway; Growth hormone synthesis, secretion and action; Huntington disease; Tuberculosis; Hepatitis B; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Pathways in cancer; Viral carcinogenesis; MicroRNAs in cancer; Renal cell carcinoma; Prostate cancer","Heme signaling; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RORA activates gene expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; HATs acetylate histones; SUMOylation of transcription cofactors; Pre-NOTCH Transcription and Translation; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production; Formation of the beta-catenin:TCF transactivating complex; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation; Attenuation phase; CD209 (DC-SIGN) signaling; Activation of the TFAP2 (AP-2) family of transcription factors; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Regulation of gene expression by Hypoxia-inducible Factor; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells","Androgen receptor signaling pathway; Angiogenesis; TNF-alpha signaling pathway; Notch signaling; Initiation of transcription and translation elongation at the HIV-1 LTR; IL-6 signaling pathway; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling pathway; Wnt signaling pathway and pluripotency; Clear cell renal cell carcinoma pathways; Ebola virus pathway in host; Type 2 papillary renal cell carcinoma; Ciliary landscape; Hepatitis B infection; Male infertility; TGF-beta receptor signaling in skeletal dysplasias; Overlap between signal transduction pathways contributing to LMNA laminopathies; 15q13.3 copy number variation syndrome; TGF-beta receptor signaling; Sudden infant death syndrome (SIDS) susceptibility pathways",2092.2,1986.4,2103.4,2357.5,2433.6,1857.4,0.9298337970970896,-0.10495522977663956,0.44683946852685524,0.34984847341143177,0.6330586694054633,0.1985560394007671,5159]
["Q92797-1","Symplekin [OS=Homo sapiens]",28,34,94,34,1274,141.1,6.13,244.46,"cell adhesion;RNA metabolism OR transcription;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","","SYMPK","ENSG00000125755","mRNA surveillance pathway; Tight junction","mRNA Splicing - Major Pathway; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs","",10786.3,10978.7,10648.7,12437.5,12592.7,13783.1,0.8351183743716716,-0.2599473871032092,0.008065358434389377,2.0933763272684005,0.10737651146985784,0.9690907098345194,549]
["Q92845","Kinesin-associated protein 3 [OS=Homo sapiens]",10,7,10,6,792,91.1,5.08,27.94,"cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity;other molecular function","KIFAP3","ENSG00000075945","","COPI-dependent Golgi-to-ER retrograde traffic; Translocation of SLC2A4 (GLUT4) to the plasma membrane; MHC class II antigen presentation; Kinesins; Intraflagellar transport","Genes related to primary cilium development (based on CRISPR)",347.8,333.3,354.1,388.8,370.6,430.5,0.8699890747121606,-0.20093081111858743,0.05150717332654609,1.288132283207514,0.24734949398405084,0.6066889737580949,1522]
["Q92882","osteoclast-stimulating factor 1 [OS=Homo sapiens]",37,5,15,5,214,23.8,5.68,53.68,"signal transduction;other biological processes","other cell component","other molecular function","OSTF1","ENSG00000134996","","Neutrophil degranulation","",1169.5,1037.2,1275.5,1365.7,1370.2,1973.4,0.7394304886076487,-0.4355135641344226,0.1275746295045989,0.894235684248656,0.3759850673585135,0.42482940319089924,2480]
["Q92890-1","Isoform Long of Ubiquitin recognition factor in ER-associated degradation protein 1 [OS=Homo sapiens]",37,13,34,13,343,38.7,6.34,102.54,"","","","UFD1","","","","",4615.9,4716.1,4647.7,4680.2,4671.1,5170.7,0.9626566588624157,-0.05490675671416034,0.34164665986465353,0.46642282083457876,0.5772296433080797,0.23865137405367842,4326]
["Q92918","mitogen-activated protein kinase kinase kinase kinase 1 [OS=Homo sapiens]",23,14,25,14,833,91.2,8.34,62.26,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes","","kinase activity;other molecular function","MAP4K1","ENSG00000104814; ENSG00000282928","MAPK signaling pathway","","B cell receptor signaling pathway; Cardiac hypertrophic response; Hepatocyte growth factor receptor signaling; TGF-beta signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; EGF/EGFR signaling pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Yap signaling pathway; Insulin signaling; Modulators of TCR signaling and T cell activation; Malignant pleural mesothelioma; T-cell receptor (TCR) signaling pathway",1600.4,1652.2,1682.9,1601.1,1634,2020.1,0.9391650175064699,-0.09054942367307578,0.47906349056546027,0.3196069254685709,0.6535041158161532,0.18475167285678804,5358]
["Q92963","GTP-binding protein Rit1 [OS=Homo sapiens]",17,2,3,2,219,25.1,9.1,10.42,"signal transduction","plasma membrane;other membranes","other molecular function","RIT1","ENSG00000143622","","Signalling to p38 via RIT and RIN","Ectoderm differentiation; Ectoderm differentiation",108.5,121.1,110.3,111.9,101.5,135.3,0.9747634069400629,-0.036876002235032956,0.7983061554687072,0.09783052201820511,0.8725616405444565,0.05920388333413233,6687]
["Q92966","snRNA-activating protein complex subunit 3 [OS=Homo sapiens]",11,2,2,2,411,46.7,5.27,3.54,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SNAPC3","ENSG00000164975","","RNA polymerase II transcribes snRNA genes; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter","",14.6,20.6,15,15.9,16.3,317.4,0.1435926773455378,-2.799945915549826,0.37669693167353946,0.42400791726070247,0.5944036860107729,0.2259185060961093,4632]
["Q92997","segment polarity protein dishevelled homolog DVL-3 [OS=Homo sapiens]",11,6,9,4,716,78,6.65,16.05,"cell-cell signaling;developmental processes;signal transduction;other biological processes","cytosol;other cell component","signal transduction activity or receptor binding;other molecular function","DVL3","ENSG00000161202","mTOR signaling pathway; Wnt signaling pathway; Notch signaling pathway; Hippo signaling pathway; Signaling pathways regulating pluripotency of stem cells; Melanogenesis; Cushing syndrome; Alzheimer disease; Pathways of neurodegeneration; Human papillomavirus infection; Pathways in cancer; Basal cell carcinoma; Breast cancer; Hepatocellular carcinoma; Gastric cancer","WNT mediated activation of DVL; Degradation of DVL; RHO GTPases Activate Formins; PCP/CE pathway; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Negative regulation of TCF-dependent signaling by DVL-interacting proteins; WNT5:FZD7-mediated leishmania damping","Alzheimer's disease and miRNA effects; Neural crest differentiation; Notch signaling; Wnt signaling pathway; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Ciliary landscape; Joubert syndrome; Malignant pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)",752.1,807,711.8,795.1,785.1,2214,0.5985187918401771,-0.7405315503601481,0.3456955368319431,0.4613062274630067,0.5795157519964844,0.23693475484761978,4360]
["Q93034","Cullin-5 [OS=Homo sapiens]",22,18,47,18,780,90.9,7.94,120.07,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;transport;signal transduction","cytosol;other cell component","transporter activity;other molecular function","CUL5","ENSG00000166266","Ubiquitin mediated proteolysis; Human immunodeficiency virus 1 infection","Antigen processing: Ubiquitination & Proteasome degradation; Vif-mediated degradation of APOBEC3G; Neddylation; Inactivation of CSF3 (G-CSF) signaling; Downregulation of ERBB2 signaling","Apoptosis-related network due to altered Notch3 in ovarian cancer; Dual hijack model of Vif in HIV infection; Modulators of TCR signaling and T cell activation",4807.4,4936.2,4522.9,4815.3,4629,3492.8,1.1027587326371444,0.14111718503445492,0.3619401665843552,0.4413632180579543,0.5883942788178496,0.2303315587349861,4496]
["Q93086-1","Isoform 2 of P2X purinoceptor 5 [OS=Homo sapiens]",6,2,2,2,421,47.1,7.28,7.62,"","","","P2RX5","","","","",268.7,341.2,327.2,349.1,274.4,254.6,1.0671905249971527,0.09381776278927523,0.6171558001716386,0.20960518505368517,0.7515481078731268,0.12404321425854602,6002]
["Q969F2-1","protein naked cuticle homolog 2 [OS=Homo sapiens]",3,1,1,1,451,50,7.96,4.31,"cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","NKD2","ENSG00000145506; ENSG00000276920","Wnt signaling pathway; Hippo signaling pathway","","Wnt signaling pathway and pluripotency; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma",23.3,21,23.1,20.4,21.2,81,0.5497553017944535,-0.8631384825089229,0.41136972244370396,0.3857676763251109,0.6144903538403909,0.21148493020107612,4893]
["Q969H4","Connector enhancer of kinase suppressor of Ras 1 [OS=Homo sapiens]",8,3,3,3,720,79.7,5.38,10.8,"signal transduction","plasma membrane;other membranes;other cell component","other molecular function","CNKSR1","ENSG00000142675","","Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants","",69.5,61.5,80.3,82.3,79.1,88.5,0.8455382152861145,-0.24205813415176314,0.10281658780069383,0.9879368132672696,0.3423628429317864,0.46551337596143677,2195]
["Q969M1","Mitochondrial import receptor subunit TOM40B [OS=Homo sapiens]",5,2,6,2,308,33.9,7.24,24.12,"cell organization and biogenesis;transport","other membranes;mitochondrion;other cell component","transporter activity;other molecular function","TOMM40L","ENSG00000158882","Amyotrophic lateral sclerosis; Pathways of neurodegeneration","","",376.3,374,398.4,336.9,377.6,679.3,0.8241498062849762,-0.27902149395864706,0.49248691243578224,0.3076053061459498,0.6630294424374898,0.17846718591765667,5429]
["Q969R5-1","Lethal(3)malignant brain tumor-like protein 2 [OS=Homo sapiens]",2,1,1,1,705,79.1,6.84,4.57,"cell organization and biogenesis;other biological processes","nucleus","other molecular function","L3MBTL2","ENSG00000100395","","SUMOylation of chromatin organization proteins; Transcriptional Regulation by E2F6","",98,91.1,79.8,135.2,130.1,288.8,0.48529146363472303,-1.043076611830721,0.14348975211791334,0.8431791146621569,0.39695934830803503,0.40125396605669233,2642]
["Q969S9","Ribosome-releasing factor 2, mitochondrial [OS=Homo sapiens]",15,12,19,11,779,86.5,6.51,52.92,"cell organization and biogenesis;protein metabolism;other metabolic processes","mitochondrion","other molecular function","GFM2","ENSG00000164347","","Mitochondrial translation termination","",2875,2861.7,2717.9,2776.4,2718.5,2843.1,1.0139841688654354,0.020035128004348774,0.5638495232261975,0.2488367824563981,0.7120207611023286,0.14750734301942497,5788]
["Q969V6","MKL/myocardin-like protein 1 [OS=Homo sapiens]",2,2,3,1,931,98.9,5.86,5.08,"cell organization and biogenesis;stress response;other biological processes","cytosol;nucleus;other cell component","cytoskeletal activity;other molecular function","MRTFA","ENSG00000196588","","RHO GTPases Activate Formins; SUMOylation of transcription cofactors","",44.4,35.5,43.8,47.7,47.3,138.9,0.5288584865327063,-0.919046361376058,0.2962264075620605,0.528376228234552,0.545920023416818,0.26287097621986283,3966]
["Q969X6","U3 small nucleolar RNA-associated protein 4 homolog [OS=Homo sapiens]",8,6,11,6,686,76.8,8.85,25.28,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","UTP4","ENSG00000141076; ENSG00000262788","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",1078.6,1064.2,1103.9,1154.1,1180.9,1315.6,{"$f":"AVERAGE(S4994:U4994)/AVERAGE(V4994:X4994)","v":0.8893606530433354},{"$f":"LOG(Y4994,2)","v":-0.169159516277258},{"$f":"TTEST(V4994:X4994,S4994:U4994,2,2)","v":0.05852283086221164},1.2326746743768333,{"$f":"AA4994*7309/AE4994","v":0.26161674053327516},0.5823344694891652,1635]
["Q96A26","Protein FAM162A [OS=Homo sapiens]",12,2,6,2,154,17.3,9.77,21.68,"stress response;other biological processes","other membranes;cytosol;mitochondrion","","FAM162A","ENSG00000114023","","","",469.5,458.1,586.7,637.5,644.6,379.6,0.9112956610699887,-0.1340088964504195,0.6370278069414383,0.19584160983474758,0.7661734804895463,0.11567288429809104,6077]
["Q96AA3","Protein RFT1 homolog [OS=Homo sapiens]",5,3,6,3,541,60.3,8.85,12.36,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport","other membranes;ER/Golgi","transporter activity","RFT1","ENSG00000163933","","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective RFT1 causes CDG-1n","",580.2,612.4,601.1,544.3,554.9,433.3,1.1704404567699838,0.2270515428158643,0.09518366592949619,1.0214375726798155,0.3311268035595848,0.48000566320179505,2101]
["Q96AC1","Fermitin family homolog 2 [OS=Homo sapiens]",3,2,2,2,680,77.8,6.7,1.98,"cell adhesion;cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","FERMT2","ENSG00000073712","","RAC1 GTPase cycle; RAC3 GTPase cycle; Cell-extracellular matrix interactions","",108.9,128.7,113.3,106.7,88.4,124,1.0996552804763395,0.13705133912285442,0.4234899177990082,0.37315692463995165,0.6194292193702123,0.20800831219856553,4997]
["Q96AJ9-1","Isoform 1 of Vesicle transport through interaction with t-SNAREs homolog 1A [OS=Homo sapiens]",34,7,13,6,203,23.4,6.15,32.44,"","","","VTI1A","","","","",1734.8,1809.9,1663.9,1518.5,1449.6,1486.4,1.1692894825457403,0.22563214401128656,5.7214836989163504E-3,2.2424913350711835,0.09334447400754377,1.0299113871853545,448]
["Q96AY2","crossover junction endonuclease EME1 [OS=Homo sapiens]",4,1,1,1,570,63.2,7.05,0,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","EME1","ENSG00000154920","Homologous recombination; Fanconi anemia pathway","Fanconi Anemia Pathway; Resolution of D-loop Structures through Holliday Junction Intermediates","",21.1,17.7,23.3,17.9,18.2,4.9,1.5146341463414636,0.5989693587150356,0.20706603254602876,0.6838911376479239,0.465818907934418,0.3317828871089337,3249]
["Q96AZ6-1","Interferon-stimulated gene 20 kDa protein [OS=Homo sapiens]",38,6,28,6,181,20.4,8.92,94.24,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ISG20","ENSG00000172183; ENSGGOG00000010365; ENSPTRG00000044668","","Interferon alpha/beta signaling","",2244,2248,2417.8,3119.9,2690.3,2242.1,0.8581150727121443,-0.22075696965740116,0.21657636998113916,0.6643889297357575,0.47765741949068985,0.3208834719351024,3314]
["Q96BD0","solute carrier organic anion transporter family member 4A1 [OS=Homo sapiens]",7,5,8,5,722,77.1,7.83,22.06,"transport","plasma membrane;other membranes","transporter activity","SLCO4A1","ENSG00000101187","","Transport of organic anions","",821.9,879.9,869.6,873.2,829.8,1424.6,0.8221639595856248,-0.2825019636407159,0.3895288678278314,0.40946035140923676,0.6011542430223015,0.22101408324012717,4736]
["Q96BI3-1","gamma-secretase subunit APH-1A [OS=Homo sapiens]",5,2,3,2,265,29,7.9,9.98,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle","enzyme regulator activity;other molecular function","APH1A","ENSANAG00000030676; ENSCANG00000034955; ENSCATG00000033983; ENSCCAG00000036376; ENSCSAG00000018098; ENSG00000117362; ENSGGOG00000017118; ENSMLEG00000037901; ENSMNEG00000034177; ENSNLEG00000009799; ENSPANG00000008739; ENSPPAG00000033416; ENSPPYG00000000905; ENSPTRG00000001250; ENSRBIG00000035934; ENSRROG00000045010; ENSSBOG00000025150","Notch signaling pathway; Alzheimer disease","Amyloid fiber formation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; EPH-ephrin mediated repulsion of cells; NOTCH2 Activation and Transmission of Signal to the Nucleus; Activated NOTCH1 Transmits Signal to the Nucleus; Nuclear signaling by ERBB4; NOTCH4 Activation and Transmission of Signal to the Nucleus; NRIF signals cell death from the nucleus; Regulated proteolysis of p75NTR; Noncanonical activation of NOTCH3","Alzheimer's disease and miRNA effects; Notch signaling; Alzheimer's disease; Notch signaling pathway (Netpath); Notch signaling pathway; Delta-Notch signaling pathway",449.4,471.3,463.2,556.3,523,475.5,0.8900823257010548,-0.1679893145523851,0.07901123447611251,1.102311152708384,0.30603768563111095,0.5142250909893423,1887]
["Q96BR5","Cytochrome c oxidase assembly factor 7 [OS=Homo sapiens]",39,8,16,8,231,25.7,6.02,41.77,"","mitochondrion;nucleus","","COA7","ENSG00000162377","Thermogenesis","","",1857,1910.3,1930,2468.3,2416.3,1953.5,0.8331700326113979,-0.2633171453076867,0.08260481382355493,1.0829946432838566,0.3125044431865233,0.5051438034793582,1932]
["Q96BY9","Store-operated calcium entry-associated regulatory factor [OS=Homo sapiens]",5,1,1,1,339,37,7.58,2.79,"transport;other biological processes","other membranes;ER/Golgi;other cell component","","SARAF","ENSG00000133872","","","",92.7,103.3,86,96.1,99.2,189.2,0.7334200260078024,-0.4472884355630328,0.33145925459574477,{"$f":"-LOG10(AA5059)","v":0.4795698506432715},0.57205093077693,{"$f":"-LOG10(AC5059)","v":0.24256530342602423},4235]
["Q96C01","Protein FAM136A [OS=Homo sapiens]",54,7,9,7,138,15.6,7.61,27.53,"","other cell component","","FAM136A","ENSG00000035141","","","",695,662.3,916.6,1009.1,1089.2,838.8,0.7741990398692588,-0.3692235764288225,0.11190747188574823,0.9511409153446104,0.3551592323113043,0.44957689142486856,2303]
["Q96C92-4","Isoform 4 of Serologically defined colon cancer antigen 3 [OS=Homo sapiens]",6,1,1,1,362,40,4.88,2.97,"","","","ENTR1","","","","",25.6,18.4,23.2,18.1,23.8,34.3,0.8818897637795275,-0.18132976471456175,0.5945765034021122,0.22579225733160938,0.7351987249815662,0.13359525479652384,5911]
["Q96CM4","Nucleoredoxin-like protein 1 [OS=Homo sapiens]",4,1,3,1,212,23.9,4.84,6.94,"other biological processes","other cell component","","NXNL1","ENSG00000171773","","","",680.2,689.5,775.5,582,612.8,584.8,1.2054394245897955,0.26955915484781323,0.01875391284176064,1.726908106693698,0.15809959511006752,0.8010692422859352,867]
["Q96CM8","Acyl-CoA synthetase family member 2, mitochondrial [OS=Homo sapiens]",19,10,15,10,615,68.1,7.55,41.94,"other metabolic processes","mitochondrion","other molecular function","ACSF2","ENSG00000167107","","Mitochondrial Fatty Acid Beta-Oxidation","Mitochondrial long chain fatty acid beta-oxidation",1140.6,1218.9,1386.3,1234.5,1116.5,1513.5,0.969284512873593,-0.04500789460900684,0.7888971306115444,0.10297962355915617,0.8660332123219853,0.062465452495831804,6658]
["Q96CV9-2","Isoform 2 of Optineurin [OS=Homo sapiens]",41,23,58,1,571,65.2,5.17,167.77,"","","","","","","","",107.4,95.6,87.8,94.5,91.1,97.3,1.0279250618593143,0.03973509252334171,0.682062288533239,0.1661759621015742,0.7947064031387604,0.09979328775493554,6273]
["Q96CW6","Probable RNA polymerase II nuclear localization protein SLC7A6OS [OS=Homo sapiens]",42,7,11,7,309,35,4.6,35.29,"transport;developmental processes;other biological processes","nucleus;other cell component","","SLC7A6OS","ENSG00000103061","","","",426.1,427.3,439.7,445.7,471.8,540.2,0.8870823900665432,-0.17285999011258893,0.12661266245162614,0.8975228586324706,0.37511631530560824,0.4258340462382336,2467]
["Q96D71","RalBP1-associated Eps domain-containing protein 1 [OS=Homo sapiens]",19,9,15,9,796,86.6,5.69,50,"transport","plasma membrane;other membranes;cytosol","other molecular function","REPS1","ENSG00000135597","","Cargo recognition for clathrin-mediated endocytosis","",1182,1197.2,1247.3,1216.3,1242,1006.1,1.0467902089827965,0.06597233549970805,0.5229538948364375,0.28153659813224696,0.6832803034250128,0.16540109828378247,5594]
["Q96DI7","U5 small nuclear ribonucleoprotein 40 kDa protein [OS=Homo sapiens]",35,10,29,10,357,39.3,8.1,88.99,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","","SNRNP40","ENSG00000060688","Spliceosome","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","mRNA processing",3530.1,3612.3,3484.5,3716.6,3518.5,2539.9,1.0871508951406648,0.1205521984723916,0.480762815452639,0.3180691301655454,0.6546004877316204,0.1840236754425081,5368]
["Q96DP5","Methionyl-tRNA formyltransferase, mitochondrial [OS=Homo sapiens]",7,3,7,3,389,43.8,9.66,12.69,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","mitochondrion","other molecular function","MTFMT","ENSG00000103707","One carbon pool by folate; Aminoacyl-tRNA biosynthesis; Metabolic pathways","Mitochondrial translation initiation","One-carbon metabolism",276,289.2,276.1,249.7,254.4,202.6,1.1904627140229234,0.25152243527719526,0.05866183035420044,1.2316443903781789,0.26159811962101953,0.582365382064705,1639]
["Q96E11","Ribosome-recycling factor, mitochondrial [OS=Homo sapiens]",27,5,18,5,262,29.3,9.79,55.07,"cell organization and biogenesis;protein metabolism;other metabolic processes","mitochondrion","translation activity","MRRF","ENSG00000148187","","Mitochondrial translation termination","",1591.9,1375.3,1744.7,1519,1811.9,1246.7,1.0293385180006989,0.041717518602835096,0.8298867696048793,0.08098115905813402,0.8934515243838654,0.0489290058485521,6789]
["Q96ED9-2","Isoform 2 of Protein Hook homolog 2 [OS=Homo sapiens]",16,10,11,10,717,83,5.47,26.51,"","","","HOOK2","","","","",712.8,771.8,716.9,917.4,973.5,1729,0.608165971435675,-0.7174629990290341,0.14589860136857538,0.8359488713746867,0.3990916457346248,0.39892736329422174,2672]
["Q96EE3","nucleoporin Seh1 [OS=Homo sapiens]",29,9,23,9,360,39.6,8.09,84.51,"cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","SEH1L","ENSG00000085415","Nucleocytoplasmic transport; mTOR signaling pathway; Amyotrophic lateral sclerosis","Amino acids regulate mTORC1","",2547.5,2973.3,2814.1,3056.7,2473.5,1927.1,1.117683343837582,0.16051150930490926,0.4490797548147251,0.3476765231390969,0.6341429536207159,0.19781282891576796,5176]
["Q96EP0-1","E3 ubiquitin-protein ligase RNF31 [OS=Homo sapiens]",11,9,15,9,1072,119.6,6.57,36.21,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","RNF31","ENSG00000092098; ENSG00000285152","Necroptosis; NOD-like receptor signaling pathway; Shigellosis","Regulation of TNFR1 signaling; TNFR1-induced NFkappaB signaling pathway","Regulation of toll-like receptor signaling pathway",1105.7,1053.4,1046.9,1041.2,1028.9,1726.4,0.8444620044778084,-0.2438955826772925,0.44258907060700803,0.3539993148409185,0.6309505592094055,0.2000046703973448,5127]
["Q96ES6","Major facilitator superfamily domain-containing protein 3 [OS=Homo sapiens]",2,1,1,1,412,42.7,9.17,2.16,"transport","other membranes","transporter activity","MFSD3","ENSG00000167700","","","",47.3,43.2,50.4,40.9,54.3,90.4,0.7591594827586207,-0.3975250988179356,0.3747105625791178,0.426304064565208,0.5935759648657937,0.2265236928663097,4614]
["Q96EX1","small integral membrane protein 12 [OS=Homo sapiens]",12,1,2,1,92,10.8,8.44,6.31,"","other membranes","","SMIM12","ENSG00000163866","","","",115.2,148.8,134.7,121,119.9,143.6,1.0369310793237974,0.052320007148142104,0.7227402542883189,0.14101775581412446,0.8200106362299477,0.08618051441382403,6442]
["Q96F10","Diamine acetyltransferase 2 [OS=Homo sapiens]",13,3,6,3,170,19.1,6.04,4.77,"other metabolic processes","other cell component","other molecular function","SAT2","ENSG00000141504","Arginine and proline metabolism; Metabolic pathways; Ferroptosis","","Ferroptosis",606.8,670.6,597.5,648.7,568.8,674.9,0.9907524836186852,-0.013403416141118627,0.8892389057737994,0.05098154440619746,0.9282272439732504,0.03234568895123833,7002]
["Q96FF9","Sororin [OS=Homo sapiens]",6,1,1,1,252,27.6,9.61,2.45,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","CDCA5","ENSG00000146670","MicroRNAs in cancer","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion","",58.6,42.7,44.3,55,48.7,42.3,0.9972602739726029,-0.003958013568683133,0.9839864242573926,7.010893347900009E-3,0.9913103755888741,3.7903482376817543E-3,7255]
["Q96FL9","Polypeptide N-acetylgalactosaminyltransferase 14 [OS=Homo sapiens]",3,1,1,1,552,64.3,7.72,3.54,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","GALNT14","ENSG00000158089","Mucin type O-glycan biosynthesis; Other types of O-glycan biosynthesis; Metabolic pathways","O-linked glycosylation of mucins","",52.7,48,50.4,49.5,59,67.5,0.8585227272727273,-0.2200717683598305,0.19728906041141892,0.7048969955114839,0.45574770624116967,0.3412755084531499,3164]
["Q96G01","Protein bicaudal D homolog 1 [OS=Homo sapiens]",11,9,13,6,975,110.7,5.81,36.9,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","BICD1","ENSG00000151746","","COPI-independent Golgi-to-ER retrograde traffic","",520.1,603,537.6,632.6,634,860.6,0.7806976306882286,-0.3571642035910905,0.12334967627839909,0.908861985944731,0.37055601476318084,0.4311461329915765,2433]
["Q96G03","Phosphoglucomutase-2 [OS=Homo sapiens]",35,23,61,22,612,68.2,6.73,151.91,"other metabolic processes","non-structural extracellular;cytosol;other cell component","other molecular function","PGM2","ENSG00000169299","Glycolysis / Gluconeogenesis; Pentose phosphate pathway; Galactose metabolism; Purine metabolism; Starch and sucrose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars","Neutrophil degranulation; Glycogen breakdown (glycogenolysis); Glycogen synthesis; Pentose phosphate pathway; Galactose catabolism","Clear cell renal cell carcinoma pathways; Glucuronidation",7351.5,7381,7611.1,6750.5,6653,5366.7,1.1903762346698488,0.2514176290836109,0.058360186328668705,1.2338833301887393,0.261689939801374,0.582212972708724,1630]
["Q96GA7","serine dehydratase-like [OS=Homo sapiens]",20,4,11,4,329,34.7,6.89,56.45,"other metabolic processes","cytosol","other molecular function","SDSL","ENSG00000139410","Glycine, serine and threonine metabolism; Cysteine and methionine metabolism; Valine, leucine and isoleucine biosynthesis; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids","Threonine catabolism","Clear cell renal cell carcinoma pathways",752,593.1,670.1,660.8,862.7,1307.7,0.7117829895450692,-0.4904906396909892,0.23854487307214187,0.6224299130828598,0.49829221985832667,0.3025158936817932,3499]
["Q96GD0","Pyridoxal phosphate phosphatase [OS=Homo sapiens]",36,8,19,8,296,31.7,6.55,69.41,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","PDXP","ENSG00000241360","Vitamin B6 metabolism; Metabolic pathways; Biosynthesis of cofactors","","",1873.8,1847.9,1878.2,1737.1,1658.7,1715.5,1.0955921194216736,0.13171079390861198,2.9600094606108277E-3,2.5287069008719696,0.06824829384102378,1.165908201205748,317]
["Q96GM1-2","Isoform 2 of Phospholipid phosphatase-related protein type 2 [OS=Homo sapiens]",2,1,2,1,427,45.5,9.52,0,"","","","PLPPR2","","","","",86.5,85.6,77.3,91.4,97,71.1,0.9610789980732176,-0.05727307341557327,0.7088988698200314,0.14941571603238835,0.8125046008334027,0.09017417113567049,6377]
["Q96GY0","Zinc finger C2HC domain-containing protein 1A [OS=Homo sapiens]",7,2,3,2,325,35.1,9.82,8.43,"","","other molecular function","ZC2HC1A","ENSG00000104427","","","",58.7,56.4,47.1,76,75.8,75.4,0.7139084507042253,-0.4861890152874092,3.6484037759233973E-3,2.437897103470948,0.07532820112492687,1.1230424036127629,354]
["Q96HA7","Tonsoku-like protein [OS=Homo sapiens]",15,17,36,17,1378,150.8,6.42,111.68,"DNA metabolism;other metabolic processes;stress response","nucleus;other cell component","other molecular function","TONSL","ENSG00000160949","","","",1615.8,1745.7,1682.6,1758,1805,2267.3,0.8651527365658714,-0.20897324209847926,0.19118574317674247,0.7185444964245744,0.44975107720592555,0.3470277877955759,3107]
["Q96HE7","ERO1-like protein alpha [OS=Homo sapiens]",47,15,84,13,468,54.4,5.68,301.52,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","ERO1A","ENSG00000197930","Protein processing in endoplasmic reticulum; Vibrio cholerae infection; Lipid and atherosclerosis","Insulin processing; Detoxification of Reactive Oxygen Species","",8776.4,8710.6,8433.3,8106.4,8491.4,6666.4,1.1141711298905617,0.15597083885678317,0.19234150274560036,0.7159269951757833,0.45174294459112885,0.3451086216094616,3112]
["Q96HY7","Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial [OS=Homo sapiens]",10,7,11,7,919,103,6.93,32.57,"other metabolic processes;developmental processes","mitochondrion","other molecular function","DHTKD1","ENSG00000181192","Lysine degradation; Tryptophan metabolism; Metabolic pathways","Glyoxylate metabolism and glycine degradation","Integrated breast cancer pathway",748.7,727.1,674.3,664.1,649,558.4,1.148864547154689,0.20020871211132082,0.07955084318143722,1.0993552127854103,0.30666514388877886,0.5133355839034848,1896]
["Q96I15-1","selenocysteine lyase [OS=Homo sapiens]",20,7,12,7,445,48.1,7.12,36.49,"other metabolic processes","cytosol;ER/Golgi;other cell component","other molecular function","SCLY","ENSG00000132330","Selenocompound metabolism; Metabolic pathways","Metabolism of ingested SeMet, Sec, MeSec into H2Se","",1468.1,1516.2,1479.7,1424.6,1481.6,3511.3,0.6955979742890535,-0.5236743636335929,0.3965183254117454,0.40173673661550807,0.6046635594480383,0.21848620372332292,4793]
["Q96IJ6","Mannose-1-phosphate guanyltransferase alpha [OS=Homo sapiens]",32,11,44,11,420,46.3,7.21,135.66,"other metabolic processes","other cell component","other molecular function","GMPPA","ENSG00000144591","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars","Synthesis of GDP-mannose","",4653.1,4606.6,4938,4441.5,4357.7,5245,1.0109297788410874,0.015682788303080585,0.8733572539097523,0.05880806824868732,0.9191314857921353,0.036622356438348706,6945]
["Q96IV0","Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase [OS=Homo sapiens]",18,12,23,12,654,74.3,6.89,58.16,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","NGLY1","ENSG00000151092","Protein processing in endoplasmic reticulum","N-glycan trimming in the ER and Calnexin/Calreticulin cycle","",2813.5,2935,3013.5,2981.9,2885.8,3108.2,0.9761695206051759,-0.03479638839059567,0.4574737409945929,0.3396338293974046,0.6392038946529305,0.1943605875408677,5231]
["Q96JB2-1","Conserved oligomeric Golgi complex subunit 3 [OS=Homo sapiens]",15,10,13,10,828,94,5.57,37.33,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi","","COG3","ENSG00000136152","","COPI-mediated anterograde transport; Retrograde transport at the Trans-Golgi-Network; Intra-Golgi traffic","",774.4,872.9,850.5,801.7,813.5,883.3,0.9997198318991395,-4.0425376187577171E-4,0.9955361942430812,1.9429459084953885E-3,0.9970367283807454,1.2888430531519046E-3,7298]
["Q96JJ7-1","Protein disulfide-isomerase TMX3 [OS=Homo sapiens]",43,17,88,16,454,51.8,4.91,313.97,"protein metabolism;other metabolic processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","TMX3","ENSG00000166479; ENSGGOG00000005485","","Platelet degranulation","",7975.2,7986.5,7595.6,6808.6,7237.5,6445.9,1.1495852039820418,0.20111339846747037,0.017627065675418517,1.7538199773794916,0.15337645597813565,0.8142413015574003,840]
["Q96JQ2","Calmin [OS=Homo sapiens]",10,8,10,8,1002,111.6,4.94,25.17,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;nucleus;other cell component","cytoskeletal activity","CLMN","ENSG00000165959","","","Vitamin D receptor pathway",576.7,529.9,568.9,586.1,652.4,614.1,0.9044046205333046,-0.14495973216163477,0.0701626540267854,1.1538939913725272,0.28891202156719686,0.5392343868796672,1775]
["Q96K17-1","transcription factor BTF3 homolog 4 [OS=Homo sapiens]",29,4,19,2,158,17.3,6.35,49.87,"","","","Btf3l4; BTF3L4; LOC108587672; LOC110308160; LOC111143096","ENSAMEG00000009159; ENSANAG00000025045; ENSCAFG00000003782; ENSCANG00000032994; ENSCATG00000029142; ENSCCAG00000034219; ENSCGRG00001021460; ENSCGRG00015007601; ENSCJAG00000021582; ENSCJAG00000023403; ENSCPOG00000036248; ENSECAG00000024180; ENSFCAG00000024164; ENSG00000134717; ENSGGOG00000010677; ENSHGLG00000000408; ENSLCNG00005020988; ENSMFAG00000046175; ENSMLEG00000043474; ENSMMUG00000003636; ENSMNEG00000032806; ENSMODG00000000770; ENSMUSG00000028568; ENSMUSG00000114133; ENSNLEG00000016041; ENSOCUG00000001517; ENSPANG00000025278; ENSPCOG00000026062; ENSPPAG00000025800; ENSPTRG00000000735; ENSRBIG00000044688; ENSRFEG00010003696; ENSRNOG00000008512; ENSSHAG00000025846; ENSSSCG00000038762; ENSSSCG00070030088; ENSSSUG00005008763; ENSSTOG00000006129; ENSTSYG00000033616; ENSUMAG00000022798","","","",605.4,594.6,676.3,839.2,963.3,434.5,0.8387572641931158,-0.25367473882640146,0.49844006182158973,0.3023870587870278,0.6669898227488099,0.17588079270676932,5462]
["Q96KG9","N-terminal kinase-like protein [OS=Homo sapiens]",35,22,48,22,808,89.6,6.3,144.42,"protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;kinase activity;other molecular function","SCYL1","ENSG00000142186","","","",5807.1,5504.6,5745.9,5291.8,5294.8,4302.1,1.1456742361656824,0.19619688294362134,0.10279203522744326,0.9880405350564911,0.3425932446317295,0.46522120485004104,2193]
["Q96KM6","zinc finger protein 512B [OS=Homo sapiens]",8,5,5,5,892,97.2,9.83,17.38,"","nucleus","nucleic acid binding activity;other molecular function","ZNF512B","ENSG00000196700","","RHOV GTPase cycle","",315.9,303.8,281.2,364.4,357.6,324.9,0.860540643805521,-0.21668476173643736,0.037462037494583836,1.4264086058024554,0.21258542860862828,0.6724665069422757,1288]
["Q96L91-5","Isoform 5 of E1A-binding protein p400 [OS=Homo sapiens]",5,13,17,13,3122,339.5,9.16,50.24,"","","","EP400","","","","",1277.2,1370.2,1298.4,1548.5,1447.1,2157.1,0.7657732839094067,-0.3850107661745368,0.14621949164252362,0.8349947303292562,0.399371548735129,0.3986228775410688,2676]
["Q96LT4-1","Sphingomyelin synthase-related protein 1 [OS=Homo sapiens]",3,1,1,1,415,48.3,8.07,3.67,"other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi","other molecular function","SAMD8","ENSG00000156671; ENSGGOG00000011029; ENSPTRG00000002656","","Sphingolipid de novo biosynthesis","",41.8,40.5,43.6,28.5,23.2,22,1.7082767978290367,0.7725417586239469,1.3586553854683218E-3,2.8668906854077445,0.05145291301755422,1.2885900325315454,193]
["Q96LZ7-1","Regulator of microtubule dynamics protein 2 [OS=Homo sapiens]",3,1,1,1,410,47.4,6.54,2.41,"","other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cell component","cytoskeletal activity","RMDN2","ENSG00000115841","","","",34.7,33.3,23.7,31.9,29.7,34.7,0.9522326064382138,-0.07061406424840505,0.703388356600801,0.15280482496686515,0.8088523439891842,0.09213075161823413,6356]
["Q96MG8-1","Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 [OS=Homo sapiens]",9,4,6,4,357,40.7,5.66,10.9,"protein metabolism;other metabolic processes","other membranes;other cell component","other molecular function","PCMTD1","ENSG00000168300; ENSGGOG00000025636; ENSPPAG00000008533; ENSPPYG00000018582; ENSPTRG00000020242","","","",922.5,899.1,910.3,769.1,745.6,702.2,1.2323063737651674,0.3013609808396389,1.1601503661921022E-3,2.935485718552941,0.046590873771967446,1.331699144654043,182]
["Q96MW5","Conserved oligomeric Golgi complex subunit 8 [OS=Homo sapiens]",17,9,13,9,612,68.4,5.2,41.01,"transport","other membranes;ER/Golgi","","COG8","ENSG00000213380","","COPI-mediated anterograde transport; Retrograde transport at the Trans-Golgi-Network; Intra-Golgi traffic","",717.5,725.5,669.3,740.8,766.3,1032.7,0.8316796598157336,-0.2659001460740939,0.20790978398546858,0.6821250728093728,0.46671148991086914,0.33095150714256344,3256]
["Q96N11","Uncharacterized protein C7orf26 [OS=Homo sapiens]",4,1,2,1,449,50,7.69,4.92,"","","","C7orf26","ENSG00000146576","","","",23.4,20.2,19.8,16.9,20.5,24.2,1.029220779220779,0.04155248944450563,0.8145705816762329,0.08907127856917589,0.8837310941771688,0.05367986403788126,6737]
["Q96NC0","Zinc finger matrin-type protein 2 [OS=Homo sapiens]",14,2,2,2,199,23.6,9.01,4.03,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","ZMAT2","ENSG00000146007","Spliceosome","","",139.3,146.2,149.6,140.3,138.7,81.7,1.2062655946770169,0.2705475937529591,0.2725461967684156,0.5645598739335322,0.5265768311341131,0.27853825334230325,3783]
["Q96ND0","Protein FAM210A [OS=Homo sapiens]",11,3,8,3,272,30.8,9.76,22.34,"","other membranes;mitochondrion;other cell component","","FAM210A","ENSG00000177150","","","",1455,1428.1,1433.9,1388.2,1360,1193.9,1.0951015955962558,0.1310647188344529,0.11054975264349998,0.9564422248236952,0.352073264519103,0.45336695281300227,2295]
["Q96P16-1","Regulation of nuclear pre-mRNA domain-containing protein 1A [OS=Homo sapiens]",25,6,11,5,312,35.7,7.55,38.34,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","nucleus","other molecular function","LOC111142439; P15RS; RPRD1A","ENSAMEG00000000830; ENSANAG00000021312; ENSBIXG00000008485; ENSBIXG00005019871; ENSBTAG00000005497; ENSCAFG00000017862; ENSCCAG00000025615; ENSCJAG00000021044; ENSDLEG00000001661; ENSG00000141425; ENSGGOG00000007369; ENSLCNG00005017687; ENSMPUG00000001133; ENSNLEG00000006228; ENSOARG00000005585; ENSPCTG00005006209; ENSPPAG00000027698; ENSPPYG00000009111; ENSPTRG00000009974; ENSRFEG00010007667; ENSSBOG00000026758; ENSSSUG00005007348; ENSSTOG00000003343; ENSTSYG00000006414; ENSTTRG00000007088; ENSUMAG00000002096; ENSVVUG00000027590","","RNA polymerase II transcribes snRNA genes; RNA polymerase II transcribes snRNA genes","",365.2,383,413.9,467.1,485.1,466.2,0.8193034404963337,-0.2875302217491083,0.005288872618098973,2.276636892788712,0.08927568121405402,1.0492668272581047,433]
["Q96PE3-1","Type I inositol 3,4-bisphosphate 4-phosphatase [OS=Homo sapiens]",32,25,69,25,977,109.9,6.96,235.14,"other metabolic processes;signal transduction","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","INPP4A","ENSG00000040933","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of IP2, IP, and Ins in the cytosol","Insulin signaling",5671.5,5670.9,5659,5698.8,5755.4,6536.2,0.9450262362148703,-0.08157371229263145,0.28948363818266937,0.5383759778701911,0.5400295843484254,0.2675824476449356,3918]
["Q96PU5","E3 ubiquitin-protein ligase NEDD4-like [OS=Homo sapiens]",11,8,12,5,975,111.9,5.82,32.67,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","NEDD4L","ENSG00000049759","Ubiquitin mediated proteolysis; Endocytosis; Tight junction; Aldosterone-regulated sodium reabsorption","Stimuli-sensing channels; Antigen processing: Ubiquitination & Proteasome degradation; Budding and maturation of HIV virion; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity","TGF-beta signaling pathway",538,473.7,561.5,434.4,478.7,567.9,1.062255232950709,0.08713045076670055,0.5506455325783499,0.25912787988433694,0.7032444867403739,0.152893663908753,5723]
["Q96PZ2","Protein FAM111A [OS=Homo sapiens]",9,4,5,4,611,70.2,8.53,22.54,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","FAM111A","ENSG00000166801","","","",246.8,225.7,239.6,183.8,233.5,332.3,0.9499733191035219,-0.07404110032543791,0.7908056623538597,0.10193022969696941,0.8672165920696716,0.061872421562874425,6665]
["Q96QC0","Serine/threonine-protein phosphatase 1 regulatory subunit 10 [OS=Homo sapiens]",20,19,31,19,940,99,9.17,61.29,"transport;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","PPP1R10","ENSG00000204569; ENSG00000206489; ENSG00000227804; ENSG00000230995; ENSG00000231737; ENSG00000235291; ENSG00000238104","","","",4705.1,4379.8,4606.1,4978.2,5265.5,4921,0.9028203657177524,-0.14748913184209436,0.026776266199459,1.5722499830381842,0.18532928944303584,0.7320559393520046,1056]
["Q96QE3-1","ATPase family AAA domain-containing protein 5 [OS=Homo sapiens]",4,4,4,4,1844,207.4,9.19,6.82,"stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ATAD5","ENSG00000176208","","","",169.2,175.8,153.8,260.8,289.2,282.7,0.5990152515912094,-0.7393353587933588,4.9718814554833193E-4,3.3034792347856636,0.031599549180980506,1.5003191132553024,115]
["Q96QT6-1","PHD finger protein 12 [OS=Homo sapiens]",3,2,2,2,1004,109.6,7.74,5.82,"other biological processes","nucleus;other cell component","other molecular function","PHF12","ENSG00000109118","","","",69.8,62.5,64.7,66,84.1,52.2,0.9738012852199703,-0.03830069021454432,0.8613242645357946,0.06483331801596119,0.9117189065158757,0.04013903904663837,6905]
["Q96R06","Sperm-associated antigen 5 [OS=Homo sapiens]",22,16,29,16,1193,134.3,5,88.13,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity","SPAG5","ENSG00000076382","","","",1717.3,1688.9,1602.6,1794.8,1756.3,4725.7,0.6051614150396288,-0.7246080903227639,0.3303863345621156,0.48097792426631153,0.5716841191558955,0.24284387190809448,4224]
["Q96RP9","Elongation factor G, mitochondrial [OS=Homo sapiens]",38,27,168,1,751,83.4,7.01,461.06,"protein metabolism;other metabolic processes","mitochondrion","nucleic acid binding activity;other molecular function","GFM1","ENSG00000168827","","Mitochondrial translation elongation","",455,436.9,460.2,459.4,406.4,581,0.9345452032070777,-0.09766364721925913,0.5777325779892915,{"$f":"-LOG10(AA5379)","v":0.23827314216594012},0.7214500961086162,{"$f":"-LOG10(AC5379)","v":0.14179370439614772},5853]
["Q96RS0","Trimethylguanosine synthase [OS=Homo sapiens]",11,6,7,6,853,96.6,4.94,20.72,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","TGS1","ENSG00000137574","","Heme signaling; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); RORA activates gene expression; snRNP Assembly","",378.9,328.6,401.3,389.3,398.7,458.4,0.8896020539152758,-0.16876797592445578,0.2070609906342846,0.6839017125407769,0.4659509792321386,0.33165977122594165,3248]
["Q96RT7","gamma-tubulin complex component 6 [OS=Homo sapiens]",2,4,5,4,1819,200.4,6.32,14.98,"cell cycle OR cell proliferation;cell organization and biogenesis","cytosol;cytoskeleton","cytoskeletal activity","TUBGCP6","ENSG00000128159","","Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes","15q11.2 copy number variation syndrome",320.7,390.6,314.3,384,345.4,348.5,0.951479729102885,-0.07175517410457963,0.5591246569887809,0.25249135524973665,0.7094864788074652,0.14905587678897575,5760]
["Q96S59-1","Ran-binding protein 9 [OS=Homo sapiens]",16,8,14,8,729,77.8,6.79,41.53,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","other molecular function","RANBP9","ENSG00000010017","","RAF/MAP kinase cascade; L1CAM interactions; MET activates RAS signaling","Brain-derived neurotrophic factor (BDNF) signaling pathway; Ciliary landscape",631.1,631.9,669.8,599.9,632.8,2635.3,0.49968976215098243,-1.0008954350391248,0.39220136733815913,0.40649089657751,0.6029869149925546,0.2196921120856985,4754]
["Q96SB8","structural maintenance of chromosomes protein 6 [OS=Homo sapiens]",18,16,39,16,1091,126.2,6.99,104.02,"cell organization and biogenesis;DNA metabolism;stress response;other biological processes","cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMC6","ENSG00000163029","","SUMOylation of DNA damage response and repair proteins","",2472,2518.8,2414.6,2402.4,2450.8,2713.2,0.9787217170649185,-0.031029382639236193,0.6237834422710637,0.2049661573533976,0.7562171470491301,0.12135347933477719,6029]
["Q96SK2","Transmembrane protein 209 [OS=Homo sapiens]",15,6,13,6,561,62.9,8.63,35.02,"","other membranes","","TMEM209","ENSG00000146842","","","",1458.6,1398.3,1392,1442.1,1503,2114.3,0.8398031387121003,-0.2518769147211959,0.2785864418802483,0.5550400234464178,0.5320586108447177,0.2740405237869441,3827]
["Q96SU4","Oxysterol-binding protein-related protein 9 [OS=Homo sapiens]",18,12,31,12,736,83.1,6.18,87.81,"other metabolic processes;transport","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","OSBPL9","ENSG00000117859","","Synthesis of bile acids and bile salts","",4017.5,4126.8,4227.1,3944.6,3654,3240.4,1.1413783559368946,0.1907771104271818,0.07459194433551779,1.1273080722530726,0.29873562802646547,0.5247129791615933,1825]
["Q96SZ5","2-aminoethanethiol dioxygenase [OS=Homo sapiens]",22,4,12,4,270,29.7,6.04,35.36,"","cytosol","other molecular function","ADO","ENSG00000181915","Taurine and hypotaurine metabolism; Metabolic pathways","Degradation of cysteine and homocysteine","",664.8,666,739.3,864.8,833.8,1452,0.6570494508982415,-0.605926140046152,0.15008605644490444,0.823659653461738,0.4043416832126084,0.3932514853393611,2713]
["Q96T66-1","Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 [OS=Homo sapiens]",4,1,1,1,252,28.3,9.22,1.77,"other metabolic processes","mitochondrion;nucleus","other molecular function","NMNAT3","ENSG00000163864","Nicotinate and nicotinamide metabolism; Metabolic pathways; Biosynthesis of cofactors","Nicotinate metabolism","NAD+ metabolism",66.7,74.4,58.4,56.9,61.1,125.5,0.8193018480492814,-0.28753302585999624,0.5529990628043222,0.2572756047156566,0.7051413381083027,0.15172382455699046,5732]
["Q99081-1","Transcription factor 12 [OS=Homo sapiens]",7,4,4,4,682,72.9,7.02,8.37,"developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","TCF12","ENSG00000140262","","RUNX1 regulates transcription of genes involved in differentiation of HSCs; Myogenesis; NGF-stimulated transcription","",139.8,164.5,143.9,270.7,294.8,254.5,0.5465853658536586,-0.8714812608824151,8.9457238391227518E-4,3.0483845129369285,0.04061136368953304,1.3913524270848054,161]
["Q99439","Calponin-2 [OS=Homo sapiens]",60,13,71,13,309,33.7,7.33,202.24,"cell organization and biogenesis;stress response;developmental processes;other biological processes","non-structural extracellular;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","CNN2","ENSG00000064666","","Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation","Myometrial relaxation and contraction pathways; Burn wound healing",9247.3,8853.2,8741.5,9125.7,9593.1,9100.6,0.9648662444193621,-0.05159913373720318,0.21573881019107796,0.6660717207496959,0.4765291519149559,0.3219105260255759,3309]
["Q99471-1","prefoldin subunit 5 [OS=Homo sapiens]",44,5,13,5,154,17.3,6.33,46.55,"developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","LOC101567244; PFDN5","ENSCJAG00000018477; ENSG00000123349; ENSGGOG00000026308; ENSMFAG00000003143; ENSMMUG00000022030; ENSNLEG00000017706; ENSPPAG00000037126; ENSPPYG00000004575; ENSPTRG00000005010","","Prefoldin mediated transfer of substrate  to CCT/TriC","Cellular proteostasis",1148.5,1318.6,1540.5,1134.8,1939.2,971.7,0.9905825938650913,-0.013650824172595758,0.9702308588482051,0.013124916460765334,0.982190768327082,0.007804152146431468,7220]
["Q99543-1","dnaJ homolog subfamily C member 2 [OS=Homo sapiens]",35,20,42,20,621,72,8.7,115.84,"cell organization and biogenesis;other metabolic processes;other biological processes","other membranes;cytosol;nucleus;other cell component","translation activity;other molecular function","DNAJC2","ENSG00000105821","","Regulation of HSF1-mediated heat shock response","",4721.7,4689.4,4981,5345.8,5509,4623.6,0.929818327475708,-0.10497923205723515,0.276013498296761,0.5590696784693793,0.529774857944072,0.27590865629784295,3808]
["Q99567","Nuclear pore complex protein Nup88 [OS=Homo sapiens]",29,17,57,17,741,83.5,5.69,186.33,"cell cycle OR cell proliferation;other metabolic processes;transport","cytosol;nucleus","transporter activity;other molecular function","NUP88","ENSG00000108559","Nucleocytoplasmic transport; Amyotrophic lateral sclerosis","HCMV Early Events; ISG15 antiviral mechanism; tRNA processing in the nucleus; HCMV Late Events; Transcriptional regulation by small RNAs; Viral Messenger RNA Synthesis; SUMOylation of DNA damage response and repair proteins; Rev-mediated nuclear export of HIV RNA; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)","Ciliary landscape",5802.8,5658.7,5782.5,5566.2,5504.2,4704.5,1.0931289580282602,0.12846360790212952,0.1564658515837693,0.8055804318362534,0.4122598807591095,0.38482892668954644,2774]
["Q99576","TSC22 domain family protein 3 [OS=Homo sapiens]",43,4,5,3,134,14.8,4.54,11.75,"stress response;other biological processes","cytosol;nucleus","","TSC22D3","ENSG00000157514","","Stimuli-sensing channels","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway",454,413.5,502.9,753.2,790.2,501.5,0.6701550198053695,-0.5774332374727797,0.07565765524540977,1.1211471223316622,0.3005335881460326,0.5221069834572258,1840]
["Q99607","ETS-related transcription factor Elf-4 [OS=Homo sapiens]",1,1,1,1,663,70.7,5.6,2.6,"cell cycle OR cell proliferation;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","ELF4","ENSG00000102034","","","TYROBP causal network in microglia",132.7,63.5,89.4,95.6,118,87,0.9500998003992016,-0.07384902988726487,0.8328422111245736,0.0794372714971534,0.8950512749756666,0.04815208445936024,6801]
["Q99638","cell cycle checkpoint control protein rad9a [OS=Homo sapiens]",10,2,5,2,391,42.5,5.66,20.5,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus","other molecular function","RAD9A","ENSG00000172613","Cellular senescence","Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Activation of ATR in response to replication stress; Presynaptic phase of homologous DNA pairing and strand exchange; HDR through Single Strand Annealing (SSA)","Androgen receptor signaling pathway; miRNA regulation of DNA damage response; ATM signaling pathway; ATR signaling; DNA IR-double strand breaks and cellular response via ATM; DNA damage response",145.5,162.7,174,125.8,124.4,126.6,1.279723991507431,0.35583268598974294,0.0133970499859254,1.8729908222232783,0.13543435456034406,0.8682711576338361,723]
["Q99717","mothers against decapentaplegic homolog 5 [OS=Homo sapiens]",10,5,13,1,465,52.2,7.71,36.7,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","SMAD5","ENSG00000113658","TGF-beta signaling pathway; Signaling pathways regulating pluripotency of stem cells","Signaling by BMP","Differentiation of white and brown adipocyte; BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation; BMP signaling in eyelid development; Embryonic stem cell pluripotency pathways; Genotoxicity pathway; Neovascularisation processes; Osteoblast differentiation and related diseases; TGF-beta receptor signaling in skeletal dysplasias; Network map of SARS-CoV-2 signaling pathway; TGF-beta receptor signaling",1385.2,1161.7,1529,1294.6,1438.7,500,1.260600624748709,0.3341112828389149,0.4172772258662815,0.379575317542079,0.6175094642349973,0.20935638181965424,4939]
["Q99732","Lipopolysaccharide-induced tumor necrosis factor-alpha factor [OS=Homo sapiens]",4,1,1,1,161,17.1,6.44,2.51,"other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","LITAF","ENSG00000189067","Lysosome","","Intracellular trafficking proteins involved in CMT neuropathy",549.3,619.6,608.1,483,545.1,748,1.0005067282247622,7.3086913656781466E-4,0.9972867516943047,1.1799502410482783E-3,0.9982427921300565,7.6381697078395968E-4,7302]
["Q99766-1","ATP synthase subunit s, mitochondrial [OS=Homo sapiens]",5,1,1,1,215,24.9,7.56,2.9,"other metabolic processes;transport","other membranes;mitochondrion;other cell component","transporter activity;other molecular function","DMAC2L","ENSG00000125375","","Cristae formation; Formation of ATP by chemiosmotic coupling","Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation",100.4,103.3,85.2,90.2,93.5,63.2,1.1701093560145808,0.22664336742183358,0.27642893296000737,0.558416502660859,0.5300154960662891,0.2757114327431748,3812]
["Q99832","T-complex protein 1 subunit eta [OS=Homo sapiens]",67,29,204,29,543,59.3,7.65,700.66,"transport;other biological processes","cytosol;cytoskeleton;other cell component","other molecular function","CCT7","ENSG00000135624","","Formation of tubulin folding intermediates by CCT/TriC; Association of TriC/CCT with target proteins during biosynthesis; RHOBTB1 GTPase cycle; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate  to CCT/TriC; RHOBTB2 GTPase cycle; Folding of actin by CCT/TriC","VEGFA-VEGFR2 signaling pathway; 16p11.2 proximal deletion syndrome",26240.6,25470,25914.6,24108.4,23910.8,21103.7,1.1230026517984635,0.16736133444552725,0.04656531017397641,1.3319374998410742,0.23553346163432082,0.627947385049668,1445]
["Q99856","AT-rich interactive domain-containing protein 3A [OS=Homo sapiens]",21,12,15,12,593,62.9,4.91,37.81,"other biological processes","other membranes;cytosol;nucleus","nucleic acid binding activity;other molecular function","ARID3A","ENSG00000116017","","TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest","",1192.2,1218.4,1126.7,1251.8,1304.7,1370.3,0.9008098197005195,-0.15070554060862237,0.041376221900557675,1.3832491676734116,0.22302271819408265,0.651650895320483,1356]
["Q99962","Endophilin-A1 [OS=Homo sapiens]",24,8,26,3,352,39.9,5.45,63.46,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SH3GL2","ENSG00000107295","Endocytosis","Golgi Associated Vesicle Biogenesis; MHC class II antigen presentation; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; Lysosome Vesicle Biogenesis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Retrograde neurotrophin signalling","EGF/EGFR signaling pathway",285,262.4,275.3,273.3,259.5,487.1,0.806647710559859,-0.30998935595180604,0.42437251195305026,0.3722527545862709,0.6204718323394367,0.2072779294548882,4999]
["Q99996-2","Isoform 2 of A-kinase anchor protein 9 [OS=Homo sapiens]",29,95,152,1,3907,452.7,4.98,440.93,"cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","AKAP9","ENSG00000127914","","Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Signaling by BRAF and RAF1 fusions; Phase 3 - rapid repolarisation; Phase 2 - plateau phase","G protein signaling pathways; NO/cGMP/PKG mediated neuroprotection",58.6,56.2,66.5,87,69.6,84.1,0.7532197756543415,-0.40885721673033887,0.033378248950564855,1.476536450492432,0.20279436540289156,0.692944115948304,1203]
["Q9BPZ7","Target of rapamycin complex 2 subunit MAPKAP1 [OS=Homo sapiens]",6,2,2,2,522,59.1,7.55,4.33,"cell organization and biogenesis;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","MAPKAP1","ENSG00000119487","mTOR signaling pathway","PIP3 activates AKT signaling; CD28 dependent PI3K/Akt signaling; Regulation of TP53 Degradation; Constitutive Signaling by AKT1 E17K in Cancer; VEGFR2 mediated vascular permeability","Target of rapamycin (TOR) signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Head and neck squamous cell carcinoma; Interferon type I signaling pathways",126.2,107.1,112.6,111.5,137.3,208.4,0.7565616797900262,-0.40247038984155026,0.2772818067124147,0.5570786248455514,0.530676283126745,0.2751703213348962,3819]
["Q9BQ75","Protein CMSS1 [OS=Homo sapiens]",11,2,4,2,279,31.9,9.19,14.34,"","","","CMSS1","ENSG00000184220","","","",592.4,539.2,568,718.7,725.5,180.7,1.0459720598190658,0.06484431458787249,0.8973017769532432,0.04706147220196269,0.9334441627883938,0.029911655773996463,7026]
["Q9BQA9-1","Uncharacterized protein C17orf62 [OS=Homo sapiens]",21,5,25,5,187,20.8,6.8,67.12,"other metabolic processes;stress response","other membranes;ER/Golgi","","C17orf62; CYBC1","ENSG00000178927; ENSGGOG00000001586; ENSPPAG00000037586; ENSPTRG00000009804","","","",3312,3463.8,3293.8,3330.1,3147.7,2832.8,1.0815199879707003,0.11306032852664671,0.17778914907936505,0.7500947486456709,0.4360607015506977,0.36045305083795315,2980]
["Q9BQG0","Myb-binding protein 1A [OS=Homo sapiens]",42,43,162,43,1328,148.8,9.28,491.28,"other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MYBBP1A","ENSG00000132382","","B-WICH complex positively regulates rRNA expression","Energy metabolism",13521.1,14015.8,13554.8,19236,18750.8,21339.1,0.6926435165753911,-0.5298150645926156,1.689359878427216E-3,2.7722778243386332,0.05587118258563132,1.2528121361397708,221]
["Q9BRD0","BUD13 homolog [OS=Homo sapiens]",14,7,12,7,619,70.5,9.86,32.44,"RNA metabolism OR transcription;other metabolic processes","nucleus","","BUD13","ENSG00000137656","","","",824.2,871,835.1,1060.8,1097,1046.7,0.7896083632391949,-0.34079082452084447,4.0074184679516023E-4,3.3971353047265107,0.029000219388374514,1.53759871662518,101]
["Q9BRJ2","39S ribosomal protein L45, mitochondrial [OS=Homo sapiens]",43,12,47,12,306,35.3,9.03,113.97,"","other membranes;mitochondrion;translational apparatus","","MRPL45","ENSG00000277936","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",5345.9,5520.2,5506.5,5012.8,5002,5541.4,1.0524806829431352,0.07379375454783306,0.21851674995813888,0.660515267455198,0.4791895965928704,0.31949261923175504,3333]
["Q9BRP8","Partner of Y14 and mago [OS=Homo sapiens]",9,1,2,1,204,22.6,9.45,7.99,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","translation activity","PYM1","ENSG00000170473","Nucleocytoplasmic transport; mRNA surveillance pathway","","",96.7,170.2,65.3,146,67.2,179.7,0.8455077627895139,-0.24211009449631052,0.6800570570753768,0.16745464827398093,0.7933818084858625,0.10051776172017682,6265]
["Q9BRR6-1","ADP-dependent glucokinase [OS=Homo sapiens]",28,8,22,8,497,54.1,6.2,86.21,"other metabolic processes","non-structural extracellular;other membranes;ER/Golgi","kinase activity;other molecular function","ADPGK","ENSG00000159322; ENSPPAG00000038547; ENSPTRG00000007256","Glycolysis / Gluconeogenesis; Metabolic pathways; Carbon metabolism","Glycolysis","",1979.1,1917.6,2028.6,1895.7,1858.2,1815.7,1.0638645504165467,0.08931448083758463,0.040046825892786804,1.3974319003506797,0.21958158323359248,0.6584040878805658,1333]
["Q9BRX5","DNA replication complex GINS protein PSF3 [OS=Homo sapiens]",19,3,3,3,216,24.5,5.34,11.94,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes","nucleus","","GINS3","ENSG00000181938","","Unwinding of DNA","",415.8,398.7,389.1,446.3,507.4,448.6,0.858304214504742,-0.22043901246670491,0.036729266229318304,{"$f":"-LOG10(AA5571)","v":1.4349877478251722},0.21022255823812647,{"$f":"-LOG10(AC5571)","v":0.6773206832046145},1277]
["Q9BSB4","Autophagy-related protein 101 [OS=Homo sapiens]",19,4,6,4,218,25,6.15,20.06,"cell organization and biogenesis;other metabolic processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","ATG101","ENSG00000123395","Autophagy; Autophagy; Longevity regulating pathway; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration","Macroautophagy","Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Alzheimer's disease",581.3,550.5,559.3,596.5,512.2,292,1.207324908974084,0.2718139788990222,0.3484997763674843,0.4577974962529121,0.5812836297284215,0.2356119075936256,4382]
["Q9BSE5","Agmatinase, mitochondrial [OS=Homo sapiens]",12,5,17,5,352,37.6,7.59,48.36,"other metabolic processes","mitochondrion","other molecular function","AGMAT","ENSG00000116771","Arginine and proline metabolism; Metabolic pathways","Agmatine biosynthesis","",2224.8,2320.4,2326.2,2128.8,2055.2,2175.5,1.080493749508609,0.11169072645099237,0.02374318740510442,1.6244609795883178,0.17458647559749318,0.757989402101658,994]
["Q9BSJ8","Extended synaptotagmin-1 [OS=Homo sapiens]",36,32,121,32,1104,122.8,5.83,371.03,"cell organization and biogenesis;transport","plasma membrane;other membranes;ER/Golgi","other molecular function","ESYT1","ENSG00000139641","","RAC1 GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; Glycosphingolipid metabolism; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle","",11969.1,11983.5,12049.4,11421.1,11325.1,11635.5,1.0471268145554176,0.06643617354971683,0.00473018112137413,2.325122229556617,0.08432413125883785,1.0740481243923798,410]
["Q9BT17-1","Mitochondrial ribosome-associated GTPase 1 [OS=Homo sapiens]",10,3,8,3,334,37.2,9.47,26.68,"other biological processes","other membranes;mitochondrion;translational apparatus","other molecular function","MTG1","ENSG00000148824","","","",488.3,479.2,470.8,421.3,467.8,732,0.8872370612547036,-0.1726084645414451,0.5635246641127252,0.2490870711819453,0.7118565105426734,0.14760753860993645,5786]
["Q9BT30","Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial [OS=Homo sapiens]",10,1,1,1,221,24.5,7.11,0,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","mitochondrion","other molecular function","ALKBH7","ENSG00000125652","","","",61.8,67.2,50.8,95,98.1,219.2,0.43609022556390986,-1.197301440373617,0.1329542067561388,0.8762979167598363,0.3842476461765989,0.41538878422026804,2529]
["Q9BTC0","Death-inducer obliterator 1 [OS=Homo sapiens]",18,31,59,31,2240,243.7,7.88,180.8,"RNA metabolism OR transcription;other metabolic processes;signal transduction","cytoskeleton;nucleus;other cell component","other molecular function","DIDO1","ENSG00000101191","","","",4947.4,5248.7,5074.6,6515.9,6468.9,8253.1,0.7190306009539549,-0.47587492379849433,0.0285337136575114,1.544641701318523,0.18924946744351254,0.7229653339503163,1102]
["Q9BTE3-1","Mini-chromosome maintenance complex-binding protein [OS=Homo sapiens]",19,10,22,10,642,72.9,5.87,64.67,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","MCMBP","ENSG00000197771; ENSGGOG00000006006; ENSPTRG00000003000","","","",1869,1904.8,1976.4,2513.5,2607.7,2619,0.742900700240304,-0.428758708948279,1.3432488110253654E-4,3.871843535174196,0.021817345688409765,1.6611980870655667,45]
["Q9BTU6","Phosphatidylinositol 4-kinase type 2-alpha [OS=Homo sapiens]",30,15,31,14,479,54,8.29,65.4,"cell organization and biogenesis;other metabolic processes;transport","plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","kinase activity;other molecular function","PI4K2A","ENSG00000155252","Inositol phosphate metabolism; Metabolic pathways; Phosphatidylinositol signaling system","Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane","Thymic stromal lymphopoietin (TSLP) signaling pathway; Wnt signaling pathway",3769.7,3576.4,3644,3044.6,3218.8,2953.2,1.192424538333008,0.2538979692769144,3.571830079952498E-3,2.4471092096643066,0.07501869555854256,1.1248304917269145,348]
["Q9BTZ2","dehydrogenase/reductase sdr family member 4 [OS=Homo sapiens]",41,8,10,7,278,29.5,8.56,37.38,"other metabolic processes;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle","other molecular function","DHRS4","ENSG00000157326; ENSG00000284807","Retinol metabolism; Metabolic pathways; Peroxisome","Peroxisomal protein import; RA biosynthesis pathway","",1857.9,1930.5,1915.5,1788.5,1679.7,2416.4,0.9692927301770723,-0.04499566392485775,0.8068788495280219,0.09319166841455198,0.8783850925231325,0.05631504344257276,6714]
["Q9BU61-1","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [OS=Homo sapiens]",38,5,23,5,184,20.3,8.22,88.46,"cell organization and biogenesis","other membranes;mitochondrion;nucleus","","NDUFAF3","ENSG00000178057","Thermogenesis","Complex I biogenesis","",1748.4,1789.3,1856.1,2008,1792.1,2170.4,0.9034084247550456,-0.14654972716500853,0.16695645233027384,0.7773967921994013,0.42415179356342425,0.37247869220575436,2877]
["Q9BUE0","Mediator of RNA polymerase II transcription subunit 18 [OS=Homo sapiens]",15,2,3,2,208,23.6,6.54,5.4,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","MED18","ENSG00000130772; ENSG00000284944","","Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression","",172.4,163.7,210.6,148.7,183.5,211.9,1.0047785333578387,0.006877547139732977,0.972074403581175,0.012300492452255372,0.9833760298650254,0.007280381996867875,7225]
["Q9BUL5-1","PHD finger protein 23 [OS=Homo sapiens]",5,2,3,2,403,43.8,5.78,6.47,"other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","PHF23","ENSG00000040633; ENSGGOG00000005820; ENSPPAG00000042657","","","",216.8,232.8,221,250.6,258.1,1019.8,0.43873078181223424,-1.188592163980548,0.3252128131683197,0.4878323518274375,0.5685196009201743,0.24525455749387923,4181]
["Q9BUR5-1","MICOS complex subunit MIC26 [OS=Homo sapiens]",32,5,14,5,198,22.3,9.13,45.62,"cell organization and biogenesis;transport","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi","","APOO","ENSG00000184831; ENSGGOG00000001200; ENSNLEG00000010026; ENSPPYG00000020191","","Cristae formation","",1690.1,1670.5,1723.9,1416.8,1550.8,1104.2,1.2487106439412545,0.3204392088000517,0.06440984517420682,1.1910477447824284,0.27434239998734133,0.561707066411142,1716]
["Q9BV23","Monoacylglycerol lipase ABHD6 [OS=Homo sapiens]",11,3,3,3,337,38.3,8.41,9.05,"other metabolic processes;other biological processes","plasma membrane;other membranes;mitochondrion;other cytoplasmic organelle;other cell component","other molecular function","ABHD6","ENSG00000163686","Retrograde endocannabinoid signaling","Arachidonate production from DAG","",148.9,150.2,136.5,136.4,143.4,1496,0.24529789390697157,-2.0273932477142753,0.37898858424337345,0.42137387149572036,0.5953207741746867,0.22524896214501472,4653]
["Q9BV44","THUMP domain-containing protein 3 [OS=Homo sapiens]",9,6,15,6,507,57,6.37,44.86,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","THUMPD3","ENSG00000134077","","","",2181,2043.4,1703.4,1995.8,2124.5,704.2,1.2286869105606797,0.29711734034370046,0.48217605219647003,0.316794363135662,0.6551821464034207,0.1836379455335343,5379]
["Q9BV94-1","ER degradation-enhancing alpha-mannosidase-like protein 2 [OS=Homo sapiens]",5,3,7,3,578,64.7,5.31,14.41,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi","other molecular function","EDEM2","ENSG00000088298","Protein processing in endoplasmic reticulum","ER Quality Control Compartment (ERQC); Maturation of spike protein","",831.6,852.8,817.7,834.8,856.2,783.5,1.0111537684380683,0.016002407818833612,0.7194625158723837,0.1429918279592713,0.8179423749434208,0.08727729183678946,6429]
["Q9BVI4","Nucleolar complex protein 4 homolog [OS=Homo sapiens]",24,8,15,8,516,58.4,7.49,51.37,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","","NOC4L","ENSG00000184967; ENSG00000288146","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",1233.4,1341.6,1185.8,1930.9,1897.3,2223.6,0.6214349449750489,-0.6863247244853881,2.5343529746683214E-3,2.5961328984205925,0.06365493433625691,1.1961679255225266,291]
["Q9BVK2-1","Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase [OS=Homo sapiens]",5,2,4,2,526,60,9.14,10.37,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","ALG8","ENSG00000159063","N-Glycan biosynthesis; Metabolic pathways","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG8 causes CDG-1h","",211.8,263.6,244.8,167.4,203.1,220.2,1.2192314203487389,0.28597198756757075,0.11762114261289869,0.9295146060250663,0.364740318777122,0.4380162266654171,2357]
["Q9BVQ7-1","Spermatogenesis-associated protein 5-like protein 1 [OS=Homo sapiens]",29,11,17,11,753,80.7,8.09,54.08,"","cytoskeleton;other cell component","other molecular function","SPATA5L1","ENSG00000171763","","","",428.2,416.2,440,359,392.2,674.2,0.901080398484636,-0.15027225930323654,0.6635399172630712,0.178132945707415,0.7837448699540703,0.10582528885077194,6188]
["Q9BW60","Elongation of very long chain fatty acids protein 1 [OS=Homo sapiens]",4,1,1,1,279,32.6,9.6,2.12,"other metabolic processes;developmental processes","other membranes;ER/Golgi","other molecular function","ELOVL1","ENSG00000066322","Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism","Synthesis of very long-chain fatty acyl-CoAs; alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism","Omega-9 fatty acid synthesis",104.6,82.3,81.9,79.3,78,98.5,1.050820953870211,0.07151687389712302,0.6873843380580402,0.16280036741621928,0.7982351647388332,0.0978691441094478,6294]
["Q9BW62","katanin p60 ATPase-containing subunit A-like 1 [OS=Homo sapiens]",8,3,4,2,490,55.4,6.74,11.03,"cell organization and biogenesis;other biological processes","cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KATNAL1","ENSG00000102781","","","",79.1,81.5,88.3,92.9,85,94.5,0.9137298091042584,-0.13016047303103548,0.12361674356532504,0.9079227012088242,0.37105329721517893,0.4305637048755044,2435]
["Q9BWF3-1","RNA-binding protein 4 [OS=Homo sapiens]",46,15,44,15,364,40.3,7.08,116.4,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","RBM14; RBM4","ENSCATG00000036313; ENSG00000173933; ENSGGOG00000014455; ENSMFAG00000052468; ENSMLEG00000024601; ENSMMUG00000020363; ENSMNEG00000014872; ENSNLEG00000035021; ENSPPAG00000033403; ENSPTRG00000003934; ENSRBIG00000043267; ENSRROG00000044302","","Circadian Clock","",6477.2,6121.2,6237.4,4341.3,4349.3,4171,1.464498973689121,0.5504071821868023,7.6879522106137736E-5,4.114189324966363,0.020068300966920027,1.6974893944246092,28]
["Q9BWL3","Uncharacterized protein C1orf43 [OS=Homo sapiens]",9,2,2,2,253,28.8,9.6,6.68,"transport","other membranes;mitochondrion;ER/Golgi","","C1orf43","ENSG00000143612","","","",221.7,227.6,185.4,240.2,253.2,247,0.8572393300918422,-0.22223005258779446,0.062076573293925505,1.2070722646978989,0.2684719965711843,0.5711010074275995,1690]
["Q9BX10","GTP-binding protein 2 [OS=Homo sapiens]",2,1,1,1,602,65.7,8.05,1.96,"protein metabolism;other metabolic processes","non-structural extracellular;other cell component","nucleic acid binding activity;other molecular function","GTPBP2","ENSG00000172432","","Platelet degranulation","Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway",65.6,105.8,70.7,110.4,82.2,156.9,0.6927038626609441,-0.5296893762638625,0.228138132347294,0.6418021181257582,0.48784716481169454,0.3117162146265032,3418]
["Q9BXB4","Oxysterol-binding protein-related protein 11 [OS=Homo sapiens]",28,15,32,15,747,83.6,7.06,106.32,"transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","OSBPL11","ENSG00000144909","","RHOH GTPase cycle","",2574.8,2584,2665.1,2844.2,2722.2,2097.5,1.0208770991270764,0.02980919417621923,0.8302009335058483,0.08081678262190455,0.8933949680498006,0.04895649797382784,6792]
["Q9BXF6","Rab11 family-interacting protein 5 [OS=Homo sapiens]",13,7,11,7,653,70.4,9.23,33.04,"cell-cell signaling;transport;other biological processes","other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","RAB11FIP5","ENSG00000135631","Endocytosis","","",1060.9,1122.6,1015.8,1218.1,1257.4,1959.7,0.7213428932178934,-0.4712428815379615,0.16511759456823955,0.7822066468052413,0.4219736009437982,0.37471471805031137,2860]
["Q9BXL7","Caspase recruitment domain-containing protein 11 [OS=Homo sapiens]",14,13,15,13,1154,133.2,6.09,42.42,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","kinase activity;other molecular function","CARD11","ENSG00000198286","NF-kappa B signaling pathway; T cell receptor signaling pathway; B cell receptor signaling pathway","FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; Activation of NF-kappaB in B cells","B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Modulators of TCR signaling and T cell activation; T-cell receptor (TCR) signaling pathway",1005.4,993.9,1090.4,1108,1116.3,1391.9,0.8544051767048281,-0.22700770677603563,0.14818515977657115,0.8291952872464208,0.4024843302887249,0.3952510231262023,2691]
["Q9BXS9-1","Solute carrier family 26 member 6 [OS=Homo sapiens]",3,3,5,3,759,82.9,8.37,11.45,"stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component","transporter activity;other molecular function","SLC26A6","ENSG00000225697","Mineral absorption; Chemical carcinogenesis","Multifunctional anion exchangers","Proximal tubule transport",922.5,937,1025.2,850.8,873.7,1081.8,1.0279371414317784,0.03975204612972864,0.760822154046578,0.1187168498560014,0.8466579055917233,0.07229203208341282,6568]
["Q9BY12","S phase cyclin A-associated protein in the endoplasmic reticulum [OS=Homo sapiens]",5,6,9,6,1400,158.2,7.44,19.34,"","cytosol;ER/Golgi;nucleus","nucleic acid binding activity;other molecular function","SCAPER","ENSG00000140386","","","",670.8,638,661.2,725.9,802,707.4,0.8813134702277099,-0.18227283907249617,0.04431218004383856,1.353476883285485,0.23101121536406277,0.636366935032152,1402]
["Q9BY43","Charged multivesicular body protein 4a [OS=Homo sapiens]",31,6,11,6,222,25.1,4.7,34.79,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","CHMP4A","ENSG00000254505; ENSG00000285302","Endocytosis; Necroptosis","HCMV Late Events; Late endosomal microautophagy; Pyroptosis; Sealing of the nuclear envelope (NE) by ESCRT-III; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","",948.2,963.5,1462,1582,2041.1,2224.5,0.5769375470278404,-0.7935129380091552,0.031837631093001716,1.4970592537958967,0.19855055090336993,0.7021289035939955,1172]
["Q9BY50","Signal peptidase complex catalytic subunit SEC11C [OS=Homo sapiens]",33,7,57,7,192,21.5,9.2,140.87,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","SEC11C","ENSG00000166562","Protein export","SRP-dependent cotranslational protein targeting to membrane; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP); Synthesis, secretion, and deacylation of Ghrelin","",8150.7,8231.7,7882.1,7946.7,7965.9,9867.3,0.9412177704335549,-0.08739953561463014,0.477771745834387,0.3207795368612261,0.6525945973282629,0.18535652595150795,5351]
["Q9BYD3","39S ribosomal protein L4, mitochondrial [OS=Homo sapiens]",40,8,16,8,311,34.9,9.72,64.08,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL4","ENSG00000105364","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1676.3,1702.6,1916.6,1558.3,1496.3,1885.4,1.0719635627530364,0.10025586780230122,0.4529542456536933,0.34394566523595316,0.6364172590316887,0.19625805121183412,5202]
["Q9BYT3-1","Serine/threonine-protein kinase 33 [OS=Homo sapiens]",20,8,10,8,514,57.8,7.03,25.81,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction","nucleus;other cell component","kinase activity;other molecular function","STK33","ENSG00000130413","","","",700.1,670.4,709.6,643.6,667.5,778.5,0.9954536753445636,-0.006573914959371908,0.9450902142151235,0.024526733643325895,0.9643535356272983,0.01576372291797475,7163]
["Q9BYV9","Transcription regulator protein BACH2 [OS=Homo sapiens]",2,1,1,1,841,92.5,5.1,2.39,"transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","BACH2","ENSG00000112182","","","",86.6,84.8,82.7,90.4,78.5,180.7,0.7268306636155605,-0.4603088094472439,0.3799678162451236,0.4202531871176042,0.5958345352790406,0.22487432816621686,4661]
["Q9BZ95","Histone-lysine N-methyltransferase NSD3 [OS=Homo sapiens]",4,4,5,1,1437,161.5,8.21,15.42,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","other molecular function","NSD3","ENSG00000147548","Lysine degradation; Metabolic pathways","PKMTs methylate histone lysines","",198.1,186.3,176.1,204.1,236.1,369.5,0.6922316907496603,-0.5306731044952189,0.17901016216094195,0.7471223140192775,0.43714843810034243,0.3593710689754959,2993]
["Q9BZF1-1","Oxysterol-binding protein-related protein 8 [OS=Homo sapiens]",33,24,60,22,889,101.1,6.96,152,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","OSBPL8","ENSG00000091039; ENSPTRG00000005242","","Acyl chain remodelling of PS","",5948.9,5686.5,5850.4,5497.1,5783,5543.6,1.0393551953494176,0.055688773585042824,0.132445768713781,0.877961911686188,0.38292963747192454,0.4168810194125624,2528]
["Q9BZF2","Oxysterol-binding protein-related protein 7 [OS=Homo sapiens]",6,4,6,4,842,95.4,8.05,24.38,"other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","OSBPL7","ENSG00000006025","","Synthesis of bile acids and bile salts","",389.2,415.5,397.2,367.7,397.5,401.4,1.0302588719355394,0.04300688724597375,0.42262154006606606,0.37404837171003413,0.6187782124084289,0.20846498650042872,4992]
["Q9BZL4","Protein phosphatase 1 regulatory subunit 12C [OS=Homo sapiens]",36,18,25,1,782,84.8,5.57,76.28,"signal transduction;other biological processes","cytoskeleton;other cell component","enzyme regulator activity;other molecular function","PPP1R12C","ENSG00000125503","Vascular smooth muscle contraction; Focal adhesion; Regulation of actin cytoskeleton; Oxytocin signaling pathway; Proteoglycans in cancer","","Focal adhesion",32.9,27.4,27.5,15.1,18.4,34.7,1.2873900293255132,0.3644492005111857,0.36000915631890823,0.44368645343213725,0.5877388705684388,0.23081558593160936,4477]
["Q9BZQ6","ER degradation-enhancing alpha-mannosidase-like protein 3 [OS=Homo sapiens]",16,11,22,11,932,104.6,4.93,67.01,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","other molecular function","EDEM3","ENSG00000116406","Protein processing in endoplasmic reticulum","ER Quality Control Compartment (ERQC)","",1629.2,1637.5,1511.3,2068,2034.8,1794.4,0.8102150172963439,-0.3036232693320595,0.01735528414097924,1.7605682716584177,0.15209804770553628,0.8178763604121834,834]
["Q9C037-1","E3 ubiquitin-protein ligase TRIM4 [OS=Homo sapiens]",22,9,14,9,500,57.4,8.1,44.58,"protein metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;other cell component","other molecular function","TRIM4","ENSG00000146833","","Antigen processing: Ubiquitination & Proteasome degradation; Negative regulators of DDX58/IFIH1 signaling; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; TRAF6 mediated IRF7 activation; TRAF6 mediated NF-kB activation; Ovarian tumor domain proteases; TRAF3-dependent IRF activation pathway","",1236.3,1229.1,1185.6,1044.8,994.2,1105.9,1.1609272154917485,0.2152775250538515,0.009374736844997244,2.0280409143596696,0.11574316148662982,0.9365046591986165,592]
["Q9C0C9","(E3-independent) E2 ubiquitin-conjugating enzyme [OS=Homo sapiens]",34,34,79,34,1292,141.2,5.12,264.41,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","UBE2O","ENSG00000175931","Ubiquitin mediated proteolysis","Antigen processing: Ubiquitination & Proteasome degradation","",7285.1,7242.9,7426.2,7722.8,7565.1,7149.7,0.9784558063250971,-0.03142140441900348,0.4205423440230445,0.3761902689512202,0.6178379884350618,0.20912539214899153,4975]
["Q9C0J8","pre-mRNA 3' end processing protein WDR33 [OS=Homo sapiens]",23,22,38,22,1336,145.8,9.17,83.97,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","","WDR33","ENSG00000136709","mRNA surveillance pathway","mRNA Splicing - Major Pathway; Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs","",2399.6,2521.3,2543.3,2987.3,3005.9,3473.9,0.7884357406175069,-0.34293491814711063,0.015631750957811656,1.8059923726701927,0.14517467312661422,0.8381091431452843,787]
["Q9GZM5","protein YIPF3 [OS=Homo sapiens]",13,3,4,3,350,38.2,5.76,17.57,"other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","","YIPF3","ENSG00000137207","","","",519.6,508.1,538.7,573.9,549.6,590.7,0.9137790222844476,-0.13008277205383298,0.029742627112101842,1.5266206736789234,0.19272062195244002,0.7150718114422739,1128]
["Q9GZS1-2","Isoform 2 of DNA-directed RNA polymerase I subunit RPA49 [OS=Homo sapiens]",32,10,21,10,419,47.2,8.94,68.24,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","POLR1E","ENSG00000137054","RNA polymerase","B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination","Pyrimidine metabolism; Eukaryotic transcription initiation; Eukaryotic transcription initiation",1854.5,1897.4,1901.1,2302.3,2165.1,1466.7,0.9526297163849616,-0.07001254197322954,0.7359639001094328,0.1331434877926317,0.8298611764732867,0.08099455260484986,6482]
["Q9GZT6","Coiled-coil domain-containing protein 90B, mitochondrial [OS=Homo sapiens]",28,8,18,8,254,29.5,7.55,45.98,"","other membranes;mitochondrion","","CCDC90B","ENSG00000137500","","","",1855.6,1825.5,1837.4,1435.1,1775.7,1504,1.1704632221939424,0.22707960340165,0.06213509347673562,1.2066630439698371,0.2680905538497406,0.5717184880805524,1694]
["Q9GZU8","Protein FAM192A [OS=Homo sapiens]",33,7,10,7,254,28.9,5.45,17.77,"other biological processes","nucleus","","PSME3IP1","ENSG00000172775","","","",1051.1,1001.4,897.4,1528.8,1237.5,856.1,0.8143496024734983,-0.2962798145535098,0.32503023927344865,0.4880762324405959,0.5684723663196066,0.24529064170024886,4179]
["Q9GZY8-2","Isoform 2 of Mitochondrial fission factor [OS=Homo sapiens]",40,8,15,4,291,33,7.44,59.29,"","","","MFF","","","","",715.3,823.5,903.9,885.2,839.7,650.1,1.0285052631578946,0.04054917656811259,0.8151269647221663,0.08877473999170137,0.8838099666450546,0.05364110524651976,6741]
["Q9H078-2","Isoform 2 of Caseinolytic peptidase B protein homolog [OS=Homo sapiens]",32,20,53,20,677,75.4,9.01,157.62,"","","","CLPB","","","","",4975.3,5013.9,5109.8,4931.5,4727,4304.6,1.0813501299854618,0.11283372844425772,0.11547663531418878,0.9375058788073342,0.3617739937897153,0.44156265571711384,2333]
["Q9H0D6-1","5'-3' exoribonuclease 2 [OS=Homo sapiens]",43,33,111,33,950,108.5,7.47,358.53,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","XRN2","ENSG00000088930","Ribosome biogenesis in eukaryotes; RNA degradation","Major pathway of rRNA processing in the nucleolus and cytosol; Association of TriC/CCT with target proteins during biosynthesis","mRNA processing",10363.8,9787,10412.9,10274.4,11030.1,12195,0.9123628710876281,-0.13232035800021721,0.1746083270198401,0.7579350487602665,0.432028524775901,0.36448757785222424,2954]
["Q9H0H0","integrator complex subunit 2 [OS=Homo sapiens]",9,7,9,7,1204,134.2,6.05,30.57,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","","INTS2","ENSG00000108506","","RNA polymerase II transcribes snRNA genes","",689.7,665.8,608,753.6,728.6,945.9,0.808656974589185,-0.30640024143657385,0.10053083737809777,0.9977006999460855,0.3387643570292838,0.4701022900763057,2169]
["Q9H0K6","Pseudouridylate synthase 7 homolog-like protein [OS=Homo sapiens]",9,5,10,5,701,80.6,7.56,31.67,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","PUS7L","ENSG00000129317","","","",750.1,787.3,851.9,896.2,977.3,1128.3,0.795955759877407,-0.3292398485143848,0.05134076392824073,1.289537673503469,0.24736298190607217,0.6066652924062264,1517]
["Q9H0U3","Magnesium transporter protein 1 [OS=Homo sapiens]",17,8,25,8,335,38,9.63,56.67,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","transporter activity","MAGT1","ENSG00000102158","","Neutrophil degranulation; Maturation of spike protein; Miscellaneous transport and binding events; Asparagine N-linked glycosylation","",2905.3,2977,2804.1,2494.9,2499.4,4648,{"$f":"AVERAGE(S5890:U5890)/AVERAGE(V5890:X5890)","v":0.9008639017661761},{"$f":"LOG(Y5890,2)","v":-0.15061892789177184},{"$f":"TTEST(V5890:X5890,S5890:U5890,2,2)","v":0.6804398903760485},0.1672102340624382,{"$f":"AA5890*7309/AE5890","v":0.7933219267440642},0.1005505420174241,6269]
["Q9H0U4","ras-related protein Rab-1B [OS=Homo sapiens]",83,15,110,6,201,22.2,5.73,318.85,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","RAB1B","ENSG00000174903","Legionellosis","COPI-mediated anterograde transport; COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs; COPI-dependent Golgi-to-ER retrograde traffic; RAB geranylgeranylation; Golgi Cisternae Pericentriolar Stack Reorganization","",6055.3,5376.2,5535.3,4986.7,5698.4,5384,1.0558649831042186,0.07842536437482235,0.3613393171846679,{"$f":"-LOG10(AA5891)","v":0.44208478045429506},0.5882024653235496,{"$f":"-LOG10(AC5891)","v":0.23047315957364525},4490]
["Q9H115","Beta-soluble NSF attachment protein [OS=Homo sapiens]",35,8,33,5,298,33.5,5.47,97.76,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","other membranes;other cytoplasmic organelle;other cell component","other molecular function","NAPB","ENSG00000125814","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Retrograde transport at the Trans-Golgi-Network; Intra-Golgi traffic; COPII-mediated vesicle transport","",533.1,527.7,507.4,523.8,508.8,368.9,1.1189439885836605,0.16213782057252318,0.3282123690396524,0.4838450561152076,0.5711676679311474,0.2432363846291352,4200]
["Q9H1A4","anaphase-promoting complex subunit 1 [OS=Homo sapiens]",7,9,20,9,1944,216.4,6.3,56.12,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","ANAPC1","ENSG00000153107","Cell cycle; Oocyte meiosis; Ubiquitin mediated proteolysis; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection","Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Cyclin B; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Inactivation of APC/C via direct inhibition of the APC/C complex; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Cell cycle",1313.8,1360.9,1332.6,1327.7,1224.9,1026.8,1.1195451751690226,0.16291274407025413,0.18567543201752293,0.7312455569230258,0.443787355335538,0.35282507611535424,3058]
["Q9H1C4","Protein unc-93 homolog B1 [OS=Homo sapiens]",12,6,36,6,597,66.6,6.96,84.38,"stress response;transport;signal transduction;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding","UNC93B1","ENSG00000110057","","Trafficking and processing of endosomal TLR; UNC93B1 deficiency - HSE","",2849.2,3062.4,2731.1,3008.8,2941.4,2004,1.0865580448065173,0.11976524650973186,0.5349301206979723,0.27170294728235117,0.6902902987608545,0.1609682300800908,5664]
["Q9H1K1","Iron-sulfur cluster assembly enzyme ISCU, mitochondrial [OS=Homo sapiens]",20,4,6,4,167,18,9.48,17.48,"cell organization and biogenesis;other metabolic processes;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","ISCU","ENSG00000136003","","","",782.5,661.5,876.5,790.5,885.1,428.7,1.1027420044670437,0.1410953000741447,0.6608697721392593,0.17988411209286886,0.7823610567809923,0.10659277535497245,6174]
["Q9H246","Uncharacterized protein C1orf21 [OS=Homo sapiens]",11,1,1,1,121,13.9,5.22,4.29,"","","","C1orf21","ENSG00000116667","","","",73.5,56.1,80.5,68.1,80.8,43.2,1.0937011972930768,0.1292186430075192,0.6732913502934978,0.17179696483390172,0.7887620579091483,0.10305398858029197,6239]
["Q9H269","Vacuolar protein sorting-associated protein 16 homolog [OS=Homo sapiens]",18,12,37,12,839,94.6,6.77,104.51,"cell organization and biogenesis;other metabolic processes;transport","other membranes;other cytoplasmic organelle;other cell component","cytoskeletal activity","VPS16","ENSG00000215305","Salmonella infection","","Ebola virus pathway in host; Network map of SARS-CoV-2 signaling pathway",3383.7,3509.8,3475.9,3141.1,3008.9,3178,1.1116423670668953,0.1526927248908864,0.005500978449355309,2.259560056439873,0.0917960079596757,1.0371762050599995,438]
["Q9H2G9-1","Golgin-45 [OS=Homo sapiens]",3,1,1,1,400,44.9,8.54,2.25,"cell organization and biogenesis;transport","other membranes;ER/Golgi;nucleus;other cell component","other molecular function","BLZF1","ENSG00000117475","","Golgi Cisternae Pericentriolar Stack Reorganization","",58.4,56.6,58,102.7,107.5,61.2,0.6374355195283715,-0.649648682894767,0.08961689191816832,1.0476101223086676,0.3225060871639056,0.4914620838295014,2031]
["Q9H2H8-1","peptidyl-prolyl cis-trans isomerase-like 3 [OS=Homo sapiens]",39,7,18,7,161,18.1,6.79,51.85,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","CLK1; LOC111141199; PPIL3","ENSAMEG00000005917; ENSCAFG00000011929; ENSECAG00000019985; ENSFCAG00000005373; ENSG00000240344; ENSGGOG00000022268; ENSOCUG00000010661; ENSPPAG00000039183; ENSPPYG00000013062; ENSPTRG00000012793; ENSRFEG00010017851; ENSSSCG00000016096; ENSSSCG00070023158; ENSSSUG00005004462; ENSSTOG00000028255; ENSUMAG00000021460","","mRNA Splicing - Major Pathway; mRNA Splicing - Major Pathway","mRNA Processing",1363.2,1306.1,1241.4,1325.5,1363.2,1218.6,1.0008701660993526,1.2548384364966777E-3,0.9847675569038687,0.006666267641441349,0.9919605944611876,3.5055798095072104E-3,7256]
["Q9H2P9-1","Diphthine methyl ester synthase [OS=Homo sapiens]",15,4,8,4,285,31.6,5.31,21.24,"protein metabolism;other metabolic processes","cytosol","other molecular function","DPH5","ENSG00000117543; ENSPPAG00000030165; ENSPTRG00000001012","","Synthesis of diphthamide-EEF2","",1127.9,1214.4,1157,1197.2,1096.9,675.4,1.1784138743896277,0.236846321565215,0.33658114287527635,0.47291021924141724,0.5751862457973801,0.24019150761425537,4277]
["Q9H329","Band 4.1-like protein 4B [OS=Homo sapiens]",1,1,2,1,900,99.7,9.04,2.25,"cell organization and biogenesis;stress response;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity","EPB41L4B","ENSG00000095203","Tight junction","","Glucocorticoid receptor pathway; Nuclear receptors meta-pathway",172.2,182,190.9,167.3,146,167.2,1.1344432882414153,0.1819844892941593,0.07295798440778324,1.1369271726603019,0.2954293119315721,0.5295464170180058,1805]
["Q9H3E2","Sorting nexin-25 [OS=Homo sapiens]",3,3,4,3,840,97.9,6.38,7.29,"other metabolic processes;transport;other biological processes","other membranes;other cytoplasmic organelle;other cell component","other molecular function","SNX25","ENSG00000109762","","","",422.7,430.6,404,407.3,419.9,337.7,1.0793201133144474,0.11012281422214154,0.3136957826561924,0.5034913199425346,0.5607244987610933,0.2512504686128976,4089]
["Q9H3P2-1","Negative elongation factor A [OS=Homo sapiens]",38,14,42,14,528,57.2,9.03,144.18,"developmental processes;other biological processes","cytosol;nucleus","other molecular function","NELFA","ENSG00000185049","","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat","Initiation of transcription and translation elongation at the HIV-1 LTR",3181.6,3318.5,2986.8,4012.5,4100.4,4799.8,0.7346952999759927,-0.44478204950484357,0.012883364315366162,1.8899707120687042,0.13281313086179306,0.8767589853677978,709]
["Q9H3S7","Tyrosine-protein phosphatase non-receptor type 23 [OS=Homo sapiens]",20,27,56,27,1636,178.9,6.92,172.73,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","PTPN23","ENSG00000076201","","Interleukin-37 signaling","",5898,6181.1,6004.8,5749.2,5574.5,7359.2,0.9679385962564698,-0.047012565658251744,0.7454824882906259,0.127562553858303,0.8368501776864053,0.07735228732122668,6511]
["Q9H3Z4","DnaJ homolog subfamily C member 5 [OS=Homo sapiens]",32,5,14,5,198,22.1,5.07,43.26,"cell-cell signaling;transport;other biological processes","plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","DNAJC5","ENSG00000101152","Protein processing in endoplasmic reticulum","Neutrophil degranulation; Sensory processing of sound by inner hair cells of the cochlea; GABA synthesis, release, reuptake and degradation","",2239.9,1700.8,2105.6,1614.8,1876,979.2,1.3526398210290826,0.43577773170766093,0.16714899822027815,0.7768962219353615,0.42419862083056004,0.3724307478106193,2880]
["Q9H488-1","GDP-fucose protein O-fucosyltransferase 1 [OS=Homo sapiens]",9,2,8,2,388,43.9,8.53,26.45,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","POFUT1","ENSG00000101346; ENSPTRG00000013375","Other types of O-glycan biosynthesis","Pre-NOTCH Processing in the Endoplasmic Reticulum","Delta-Notch signaling pathway",366.5,408.2,380.4,391.9,368.3,277,1.11367142306209,0.155323643592047,0.34940003411003734,0.45667705695526223,0.581988343051564,0.23508571397396283,4388]
["Q9H490","Phosphatidylinositol glycan anchor biosynthesis class U protein [OS=Homo sapiens]",11,4,7,4,435,50,7.72,24.74,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;ER/Golgi","","PIGU","ENSG00000101464","Glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways","Attachment of GPI anchor to uPAR","",1035.5,1022.8,1049.7,852,868.4,995.1,1.1445406002577794,0.19476864048350925,0.04631262289806595,1.3343006222041311,0.23555947165063607,0.6278994284543837,1437]
["Q9H4G0-1","Band 4.1-like protein 1 [OS=Homo sapiens]",39,26,63,4,881,98.4,5.62,181.92,"cell organization and biogenesis","plasma membrane;other membranes;cytosol;cytoskeleton","cytoskeletal activity;other molecular function","EPB41L1","ENSG00000088367","","Neurexins and neuroligins; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Trafficking of AMPA receptors","Splicing factor NOVA regulated synaptic proteins",5549.3,5806,5878.2,5075.6,4925,4842.4,1.1610523479081047,0.21543301989071564,0.002746069423825857,2.561288487491339,0.06690340472914397,1.1745517803270287,300]
["Q9H4K7","Mitochondrial ribosome-associated GTPase 2 [OS=Homo sapiens]",9,2,2,2,406,43.9,9.45,8.88,"other biological processes","other membranes;mitochondrion;translational apparatus","other molecular function","MTG2","ENSG00000101181","","","",59,53.2,61.7,60,63.9,79.5,0.8549655850540807,-0.2260617465509128,0.2028206308732247,0.6928878707455824,0.4613806383605351,0.3359406344131275,3213]
["Q9H4L7","SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 [OS=Homo sapiens]",6,5,11,5,1026,117.3,5.55,27.98,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","SMARCAD1","ENSG00000163104","Signaling pathways regulating pluripotency of stem cells","","",738.5,748.6,757,1003.2,946.8,655.6,0.861260362296592,-0.21547865910936342,0.3263951439278071,0.4862563112571639,0.5693608847179814,0.24461237233948627,4190]
["Q9H583","HEAT repeat-containing protein 1 [OS=Homo sapiens]",15,31,81,31,2144,242.2,6.54,202.7,"RNA metabolism OR transcription;other metabolic processes;other biological processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity","HEATR1","ENSG00000119285","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",6854.4,7348.3,7081.4,8149,7697.9,6891.1,0.9360585803500748,-0.09532927561716548,0.28675902282382076,0.54248290820979,0.537553654223982,0.2695781815138027,3899]
["Q9H5X1-1","MIP18 family protein FAM96A [OS=Homo sapiens]",28,4,10,4,160,18.3,4.88,28.37,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","CIAO2A","ENSCANG00000036332; ENSCATG00000033389; ENSG00000166797; ENSGGOG00000016550; ENSMFAG00000035924; ENSMLEG00000042755; ENSMMUG00000014004; ENSPANG00000016877; ENSPPAG00000026013; ENSPTRG00000007153; ENSRBIG00000030155; ENSRROG00000031571","","","",623.8,614,652.9,663.9,698.2,1075.6,0.7756081552282889,-0.36660012196669706,0.2405279974702885,0.618834364449553,0.4994372538381644,0.301519066043711,3520]
["Q9H6A0-1","DENN domain-containing protein 2D [OS=Homo sapiens]",5,2,3,2,471,53.6,7.64,9.16,"","cytosol;nucleus","enzyme regulator activity","DENND2D","ENSG00000162777; ENSPPAG00000037282","","RAB GEFs exchange GTP for GDP on RABs","",109.1,116.4,110.4,116.3,116.6,260.3,0.6810624493106244,-0.5541410041683408,0.33607909045918644,0.4735585068125154,0.574865919065339,0.24043343774573891,4273]
["Q9H6K1","Uncharacterized protein C6orf106 [OS=Homo sapiens]",7,1,2,1,298,32.9,4.58,4.76,"other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","ILRUN","ENSG00000196821","","","",206.2,194.8,182.5,207.4,240.5,224.8,0.867400029730935,-0.20523060223664416,0.0647241488123425,1.1889336522647929,0.2752000021346197,0.5603515670678724,1719]
["Q9H6P5","Threonine aspartase 1 [OS=Homo sapiens]",12,3,3,3,420,44.4,7.75,6.42,"protein metabolism;other metabolic processes;other biological processes","other cell component","other molecular function","TASP1","ENSG00000089123","","","",171.5,168,159.1,142.6,141.7,177.4,1.0799220272904486,0.11092715044213466,0.37455737618094015,0.42648164592140003,0.5935906033188404,0.22651298266008843,4612]
["Q9H6U8","Alpha-1,2-mannosyltransferase ALG9 [OS=Homo sapiens]",6,3,6,3,611,69.8,8.68,22.32,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","ALG9","ENSG00000086848","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG9 causes CDG-1l","",608.9,575,592.9,510.2,559.4,731.2,0.9866725899600179,-0.019356663907174738,0.9116323368474611,0.04018027819840109,0.9424498939205225,0.0257417301113275,7070]
["Q9H788","SH2 domain-containing protein 4A [OS=Homo sapiens]",22,8,14,8,454,52.7,8.06,29.96,"other biological processes","cytosol;other cell component","other molecular function","SH2D4A","ENSG00000104611","","","",1505.7,1468.7,1390.6,1698.6,1802.6,2046,0.7868834727430055,-0.3457780877986686,0.022048225951697212,1.6566263490707058,0.16945371554253935,0.7709489041241468,951]
["Q9H7B4-1","Histone-lysine N-methyltransferase SMYD3 [OS=Homo sapiens]",7,2,9,2,428,49.1,7.25,19.06,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","SMYD3","ENSG00000185420","Lysine degradation; Metabolic pathways","PKMTs methylate histone lysines","Histone modifications",338.1,408.8,395,385.1,294.4,389.4,1.068294508373094,0.09530942530031546,0.5546308613662907,0.2559959686056377,0.7066057112996721,0.15082285660410577,5737]
["Q9H7P6","Multivesicular body subunit 12B [OS=Homo sapiens]",7,1,1,1,319,35.6,8.15,4.5,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","MVB12B","ENSG00000196814","Endocytosis","Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Late endosomal microautophagy","",54,54.7,67.5,44.7,30.3,24.9,1.7637637637637633,0.8186573411279949,0.025924875413087127,1.5862833220185275,0.18272412188452636,0.7382041165235955,1037]
["Q9H832","Ubiquitin-conjugating enzyme E2 Z [OS=Homo sapiens]",21,7,11,7,354,38.2,5.62,28.13,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","enzyme regulator activity;other molecular function","UBE2Z","ENSG00000159202","Ubiquitin mediated proteolysis","Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation","",2054.9,1885.7,2032.3,1933.4,1888.7,943.2,1.2534153148804903,0.3258645259451756,0.2860139843272809,0.5436127320188769,0.5367076280996397,0.2702622321434872,3895]
["Q9H871-1","Protein RMD5 homolog A [OS=Homo sapiens]",19,4,10,4,391,44,6.06,36.75,"protein metabolism;other metabolic processes","nucleus;other cell component","other molecular function","LOC111148095; RMD5A; Rmnd5a; RMND5A","ENSAMEG00000009979; ENSBIXG00000016128; ENSBIXG00005012781; ENSBMUG00000001433; ENSBTAG00000021140; ENSCANG00000000502; ENSCATG00000002310; ENSCHIG00000026499; ENSCPOG00000038199; ENSCSAG00000016355; ENSDLEG00000016828; ENSECAG00000020001; ENSG00000153561; ENSHGLG00000004880; ENSLCNG00005014561; ENSMFAG00000065825; ENSMMNG00015005282; ENSMMUG00000003523; ENSMNEG00000044699; ENSMPUG00000009296; ENSMUSG00000002222; ENSNVIG00000017991; ENSOARG00000020715; ENSOCUG00000009371; ENSOGAG00000007229; ENSPANG00000005829; ENSPCOG00000015308; ENSPCTG00005006099; ENSPPYG00000012209; ENSPTRG00000050213; ENSRBIG00000033920; ENSRNOG00000028422; ENSRROG00000038497; ENSSSCG00000035478; ENSSSCG00070028877; ENSSSUG00005017842","","","Ciliary landscape",440.6,404,425.5,376.5,427.2,314.8,1.1355386678587394,0.18337683416299622,0.2134726177604695,0.6706578242370426,0.4735269691081249,0.32465528128309823,3295]
["Q9H8M1","Coenzyme Q-binding protein COQ10 homolog B, mitochondrial [OS=Homo sapiens]",3,1,1,1,238,27.1,9.6,2.4,"other metabolic processes","other membranes;mitochondrion","other molecular function","COQ10B","ENSG00000115520","","Respiratory electron transport","",110.7,107.3,110.8,112.2,120.4,189.9,{"$f":"AVERAGE(S6082:U6082)/AVERAGE(V6082:X6082)","v":0.7782248520710059},{"$f":"LOG(Y6082,2)","v":-0.3617410423752262},{"$f":"TTEST(V6082:X6082,S6082:U6082,2,2)","v":0.27427802887664054},0.5618089802912267,{"$f":"AA6082*7309/AE6082","v":0.5279689526097882},0.27739161554705094,3797]
["Q9H8T0-1","AKT-interacting protein [OS=Homo sapiens]",11,3,4,3,292,33.1,9.31,11.58,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","AKTIP; FTS","ENSCSAG00000005299; ENSG00000166971; ENSGGOG00000014821; ENSMNEG00000035738; ENSNLEG00000031116; ENSPANG00000018701; ENSPTRG00000008116; ENSRROG00000038050; ENSSBOG00000028267","","","",435.7,432,443.5,486.9,446.2,359.6,1.0143111317397697,0.020500255267920358,0.8779643934410715,0.05652309690213216,0.922121246107313,0.03521197151317414,6959]
["Q9H936","Mitochondrial glutamate carrier 1 [OS=Homo sapiens]",7,2,6,2,323,34.4,9.29,22.94,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","SLC25A22","ENSG00000177542","","Organic anion transporters","",1273.5,1338.1,1215.9,1191.8,1113.2,1792.1,0.9341973591076614,-0.09820072811327422,0.7003939950274194,0.15465758608607222,0.8068053127904504,0.09323125063282287,6345]
["Q9H999","Pantothenate kinase 3 [OS=Homo sapiens]",13,4,9,2,370,41.1,6.55,21.39,"other metabolic processes","cytosol;nucleus","kinase activity;other molecular function","PANK3","ENSG00000120137","Pantothenate and CoA biosynthesis; Metabolic pathways; Biosynthesis of cofactors","Coenzyme A biosynthesis","",46.3,64.2,45.4,71.6,68,60.3,0.7798899449724863,-0.3586575440468428,0.10317671232368837,0.9864183148270115,0.34309308024287455,0.4645880410305103,2198]
["Q9H9A7","RecQ-mediated genome instability protein 1 [OS=Homo sapiens]",7,3,3,3,625,70.1,4.96,10.08,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","nucleus;other cell component","other molecular function","RMI1","ENSG00000178966","Fanconi anemia pathway","Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function","",115.5,113.2,101.5,114.5,121,189,0.7778563015312132,-0.36242443352714276,0.26404640766804705,0.5783197366797735,0.521035419450798,0.2831327528056973,3704]
["Q9H9J4-1","Ubiquitin carboxyl-terminal hydrolase 42 [OS=Homo sapiens]",2,2,2,2,1324,145.3,8.63,5.63,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","other molecular function","USP42","ENSG00000106346","","Ub-specific processing proteases","",53.6,64.9,43.6,63.8,67.5,198.3,0.4918082524271844,-1.023832151665677,0.279336367185876,0.5538725192220957,0.5325168251855941,0.2736666658801666,3834]
["Q9H9T3","elongator complex protein 3 [OS=Homo sapiens]",20,10,24,10,547,62.2,8.88,76.04,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","ELP3","ENSG00000134014","","HATs acetylate histones","Ethanol effects on histone modifications",2407.6,2439.6,2365.4,2721.4,2688.5,2101,0.9602843866913421,-0.058466373938018915,0.6494141926828989,0.18747822427713745,0.7745705506395737,0.11093901901771207,6128]
["Q9HA64","Ketosamine-3-kinase [OS=Homo sapiens]",28,8,20,8,309,34.4,7.33,43.08,"protein metabolism;other metabolic processes","cytosol","kinase activity;other molecular function","FN3KRP","ENSG00000141560","","Gamma carboxylation, hypusine formation and arylsulfatase activation","",2307,2326.2,2149.4,2250.9,2219.8,3886.1,0.8116264598889527,-0.30111219562778496,0.39653899508408563,0.4017140983410476,0.6045689434855198,0.21855416615470963,4794]
["Q9HAF1","Chromatin modification-related protein MEAF6 [OS=Homo sapiens]",18,2,3,2,191,21.6,9.32,11.04,"protein metabolism;other metabolic processes","nucleus;other cell component","","MEAF6","ENSG00000163875","","HATs acetylate histones; Regulation of TP53 Activity through Acetylation","",38.6,30.2,36,31,43.9,80.8,0.6730892742453436,-0.5711302275415867,0.32481375283864156,0.4883655907132364,0.5682297078740142,0.2454760644735532,4178]
["Q9HAP2-1","MLX-interacting protein [OS=Homo sapiens]",2,1,1,1,919,101.1,8.35,0,"other biological processes","other membranes;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","MLXIP","ENSG00000175727; ENSG00000281178","Insulin resistance; Non-alcoholic fatty liver disease","","Nonalcoholic fatty liver disease",16,21.3,17.5,22.4,16.8,27.4,0.8228228228228228,-0.2813462841107354,0.31714105445891533,0.49874753416064305,0.5628907156484245,0.24957591455868267,4118]
["Q9HAW4","Claspin [OS=Homo sapiens]",1,1,1,1,1339,151,4.82,2.74,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","ER/Golgi;nucleus","nucleic acid binding activity;other molecular function","CLSPN","ENSG00000092853","","Ub-specific processing proteases; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Apoptotic cleavage of cellular proteins","",13.2,16.5,36.3,21.7,21,56.1,0.6680161943319838,-0.5820450173388619,0.46793507412342966,0.3298144009985185,0.6461623761133851,0.1896583331058134,5293]
["Q9HB90","ras-related GTP-binding protein C [OS=Homo sapiens]",34,9,14,5,399,44.2,5.1,41.02,"RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RRAGC","ENSG00000116954","Autophagy; mTOR signaling pathway; Shigellosis","Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Macroautophagy; mTORC1-mediated signalling; Amino acids regulate mTORC1; Energy dependent regulation of mTOR by LKB1-AMPK","Target of rapamycin (TOR) signaling",1462.9,1645,1702.4,1354.1,1175,810.3,1.4404683476073548,0.5265379595247814,0.049151368360466144,1.3084643870255903,0.24142967160392947,0.6172093563514772,1488]
["Q9HBH5","Retinol dehydrogenase 14 [OS=Homo sapiens]",34,9,27,9,336,36.8,8.79,85.2,"other metabolic processes","other membranes;cytosol;ER/Golgi;nucleus","other molecular function","RDH14","ENSG00000240857","","RA biosynthesis pathway","",2757.7,2709.3,2640.2,2603.7,2663.9,2761.4,1.0097396936106613,0.013983420561750412,0.6723173177938783,0.17242570188605483,0.7881262671620619,0.10340419781664331,6235]
["Q9HBR0","Putative sodium-coupled neutral amino acid transporter 10 [OS=Homo sapiens]",16,16,33,16,1119,119.7,5.73,90.23,"transport;developmental processes","other membranes;ER/Golgi","transporter activity","SLC38A10","ENSG00000157637","","","",3960.1,4063.2,3897.9,4051.9,4349.2,5987.7,0.8285055042811075,-0.2714168126818195,0.2447754084515125,0.6112322160619237,0.5036777760056601,0.29784721128451414,3552]
["Q9HC52","chromobox protein homolog 8 [OS=Homo sapiens]",22,7,17,7,389,43.4,9.91,39.61,"protein metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","enzyme regulator activity;nucleic acid binding activity;other molecular function","CBX8","ENSG00000141570","","SUMOylation of DNA damage response and repair proteins; SUMOylation of RNA binding proteins; SUMOylation of chromatin organization proteins; SUMOylation of transcription cofactors; Oxidative Stress Induced Senescence; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN gene transcription","",1166.5,1130.1,1060.7,1282.9,1176.7,1419.3,0.8655288870556085,-0.2083461244965937,0.08621166788109708,1.0644339528126803,0.31616712520970325,0.5000832896291948,1993]
["Q9HCC9-1","Lateral signaling target protein 2 homolog [OS=Homo sapiens]",6,3,3,3,887,96.4,5.11,10.56,"other biological processes","other membranes;cytosol;other cytoplasmic organelle","other molecular function","ZFYVE28","ENSG00000159733","","","",54.1,57.3,57.8,53.8,46.8,81.2,0.9306930693069306,-0.10362263107415745,0.7111471712881074,0.14804051310396593,0.8138053350469355,0.08947946737797798,6387]
["Q9HCJ1","progressive ankylosis protein homolog [OS=Homo sapiens]",5,2,5,2,492,54.2,7.88,10.25,"transport;developmental processes;other biological processes","plasma membrane;other membranes","transporter activity","ANKH","ENSG00000154122","","Miscellaneous transport and binding events","",413.3,424.8,408.2,412.9,399.6,276.7,1.1442343004039663,0.19438249741401703,0.2962735557031212,0.5283071103314047,0.5458692761870715,0.26291134892158224,3967]
["Q9HCK8-1","Chromodomain-helicase-dna-binding protein 8 [OS=Homo sapiens]",5,11,13,5,2581,290.3,6.47,32.73,"cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","CHD8","ENSG00000100888","Wnt signaling pathway","Deactivation of the beta-catenin transactivating complex","lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Malignant pleural mesothelioma",952.6,916.3,933.2,1070.5,1104.5,947.3,0.8974473945488903,-0.15610071957029734,0.09441763405710567,1.0249468864383087,0.3295599270885317,0.4820656018971591,2094]
["Q9HD26-1","Golgi-associated PDZ and coiled-coil motif-containing protein [OS=Homo sapiens]",18,8,12,8,462,50.5,5.92,36.97,"transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","GOPC","ENSG00000047932","","RHOQ GTPase cycle; RHO GTPases regulate CFTR trafficking","",1762.7,1929.2,1999.9,2322.7,2081.8,2007.2,0.8877208852566403,-0.171821955196909,0.11252034864359124,0.9487689308460364,0.35663973470772264,0.4477702719207436,2306]
["Q9HDC9","Adipocyte plasma membrane-associated protein [OS=Homo sapiens]",50,18,71,18,416,46.5,6.16,226.63,"other metabolic processes","other membranes;other cell component","other molecular function","APMAP","ENSG00000101474","","","Ciliary landscape",10366.7,10102.2,10251,9063.3,9090.1,9211.9,1.12258590258466,0.16682584718560364,2.3268050592121231E-4,3.633240000578707,0.023952983348987898,1.6206403874138093,71]
["Q9NNX1","tuftelin [OS=Homo sapiens]",5,2,2,2,390,44.2,6,2.63,"developmental processes;signal transduction","non-structural extracellular;other cell component","extracellular structural activity;bone, tooth or skin structural activity","TUFT1","ENSG00000143367","","","",200.8,205.1,253.1,214.6,225.7,605.2,0.6303204208512673,-0.6658426915815278,0.37604933202897983,0.4247551784164593,0.5940230317267806,0.22619671603238337,4627]
["Q9NP80-1","Calcium-independent phospholipase A2-gamma [OS=Homo sapiens]",8,6,10,5,782,88.4,9.23,22.81,"other metabolic processes;transport;other biological processes","other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle","other molecular function","IPLA2(GAMMA); PNPLA8","ENSG00000135241","","Acyl chain remodelling of PC; Acyl chain remodelling of PE","Eicosanoid synthesis",878.8,806.3,839.4,783.9,762.1,313.4,1.3576960309777346,0.44116051663109557,0.22525171220396908,0.6473318991373145,0.4855101045410823,0.3138017270314279,3391]
["Q9NPF5","DNA methyltransferase 1-associated protein 1 [OS=Homo sapiens]",14,6,7,6,467,53,9.5,18.39,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","DMAP1","ENSG00000178028","","HATs acetylate histones","",467.2,471.2,481.7,591.5,574.2,645.8,0.7839359646701627,-0.3511922813961622,0.004051261724105555,2.392409699136042,0.0777182990590223,1.1094767129276886,381]
["Q9NPI1-1","Bromodomain-containing protein 7 [OS=Homo sapiens]",30,17,35,17,651,74.1,6.39,99.61,"cell-cell signaling;cell cycle OR cell proliferation;signal transduction;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","BRD7","ENSG00000166164","Hepatocellular carcinoma","Regulation of TP53 Activity through Acetylation","",2687.5,2693.6,2611.3,3309.3,3424.7,3028.7,0.8186669671299949,-0.28865141052176824,8.067423446301283E-3,2.093265147028075,0.10720872358002922,0.9697698746383463,550]
["Q9NPR2-1","Semaphorin-4B [OS=Homo sapiens]",1,1,1,1,832,92.1,6.95,2.25,"","","","","","","","",144.2,158.5,138.5,138.9,148.4,239.4,0.8376685019935446,-0.2555486685625744,0.4311052196903008,0.36541671880936527,0.6237030979248631,0.20502209880868547,5052]
["Q9NQ25-7","Isoform 7 of SLAM family member 7 [OS=Homo sapiens]",32,4,13,1,188,21.3,6.02,48.57,"","","","SLAMF7","","","","",54.5,64.4,51.6,18.6,19.7,31.5,2.4426934097421205,1.2884727977018826,0.004057900450652939,2.391698611384095,0.07764187014089616,1.1099040124118307,382]
["Q9NQ88","Fructose-2,6-bisphosphatase TIGAR [OS=Homo sapiens]",23,5,11,5,270,30,7.69,35.58,"other metabolic processes;stress response;developmental processes;other biological processes","other membranes;cytosol;mitochondrion;nucleus;other cell component","other molecular function","TIGAR","ENSG00000078237","Fructose and mannose metabolism; Metabolic pathways; Central carbon metabolism in cancer","TP53 Regulates Metabolic Genes","Genotoxicity pathway; Metabolic reprogramming in colon cancer; p53 transcriptional gene network",1010.5,1098.2,1062.7,920.3,915.5,556.2,1.3258361204013376,0.40690246255795415,0.10270299907398253,0.988416874199566,0.3426089549209212,0.46520128987629844,2191]
["Q9NQL2-1","Ras-related GTP-binding protein D [OS=Homo sapiens]",13,5,8,1,400,45.6,4.92,24.01,"stress response;other biological processes","other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component","other molecular function","RRAGD","ENSG00000025039; ENSGGOG00000024195; ENSNLEG00000013157; ENSPPAG00000029815; ENSPTRG00000018420","Autophagy; mTOR signaling pathway; Shigellosis","Amino acids regulate mTORC1; TP53 Regulates Metabolic Genes; Regulation of PTEN gene transcription; mTORC1-mediated signalling; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK","Target of rapamycin (TOR) signaling",46.5,56.9,64,43,32,65.6,1.1906116642958748,0.2517029334778085,0.4667699398740493,0.3308971204226999,0.6452849424133584,0.1902484689438384,5287]
["Q9NQS7","Inner centromere protein [OS=Homo sapiens]",17,16,29,15,918,105.4,9.44,76.56,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","enzyme regulator activity","INCENP","ENSG00000149503","","SUMOylation of DNA replication proteins; Separation of Sister Chromatids; RHO GTPases Activate Formins; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","",1850.4,1742,1905.2,2085.4,2243.2,2064.1,0.8599809157320069,-0.21762345028691432,0.015774588007786035,1.8020419746056435,0.14576038400620497,0.836360496219347,791]
["Q9NQW7-3","Isoform 3 of Xaa-Pro aminopeptidase 1 [OS=Homo sapiens]",42,21,59,20,666,74.8,5.88,197.11,"","","","XPNPEP1","","","","",5803.9,5739.9,5763.4,5401.5,5392.6,5708.2,1.0487750192397423,0.06870522754477683,0.06363615994474864,1.1962960352656051,0.27199806610302213,0.5654341837737858,1710]
["Q9NR28-1","Diablo homolog, mitochondrial [OS=Homo sapiens]",32,8,22,7,239,27.1,5.9,68.42,"stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;mitochondrion","","DIABLO","ENSG00000184047","Apoptosis; Apoptosis","Regulation of the apoptosome activity; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Release of apoptotic factors from the mitochondria","TNF-alpha signaling pathway; Nanomaterial induced apoptosis; Apoptosis; Complement system in neuronal development and plasticity",2721.9,2921.5,3116,2696.4,2651.3,2392.3,1.1317054263565889,0.17849848534371418,0.0833912861416503,1.0788793279990996,0.31369372640726817,0.5034941667149091,1943]
["Q9NR34","mannosyl-oligosaccharide 1,2-alpha-mannosidase IC [OS=Homo sapiens]",1,1,1,1,630,70.9,7.46,2.08,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","MAN1C1","ENSG00000117643","N-Glycan biosynthesis; Various types of N-glycan biosynthesis; Metabolic pathways; Protein processing in endoplasmic reticulum","Intra-Golgi traffic; Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2","",122.7,149.1,144.1,139.2,127.3,129.3,1.0507832238504293,0.07146507259884391,0.4931262378796478,0.30704188924903825,0.6636456771611758,0.17806373015769278,5431]
["Q9NRA0-1","Sphingosine kinase 2 [OS=Homo sapiens]",2,1,3,1,654,69.2,6.95,7.09,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","SPHK2","ENSG00000063176","Sphingolipid metabolism; Metabolic pathways; Calcium signaling pathway; Sphingolipid signaling pathway; Phospholipase D signaling pathway; VEGF signaling pathway; Apelin signaling pathway; Fc gamma R-mediated phagocytosis; Tuberculosis","Sphingolipid de novo biosynthesis","Sphingolipid pathway; S1P receptor signal transduction; Metabolism of spingolipids in ER and Golgi apparatus; Sphingolipid metabolism overview; Sphingolipid metabolism: integrated pathway",126.2,109.5,108.9,123.5,138.6,185.1,0.7705724508050089,-0.37599748661824195,0.1524436395104934,0.8168906912272402,0.40798629116887447,0.38935442948300064,2731]
["Q9NRB3","carbohydrate sulfotransferase 12 [OS=Homo sapiens]",18,5,8,5,414,48.4,9.32,35.01,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","CHST12","ENSG00000136213","Glycosaminoglycan biosynthesis","Chondroitin sulfate biosynthesis","Metapathway biotransformation Phase I and II",680.1,711.4,661.5,825,830.8,681.3,0.8784390911813788,-0.18698583813230535,0.13699504220914394,0.8632951494871799,0.39006496435786253,0.40886305627465025,2567]
["Q9NRG7-1","Epimerase family protein sdr39u1 [OS=Homo sapiens]",5,1,3,1,319,34.7,9.77,10.09,"","","","","","","","",135.3,139.7,137.4,120.2,107.4,127.8,1.1603826674169948,0.21460065133943004,0.03546970241976059,1.4501424551141309,0.20839875802735544,0.6811048735849577,1244]
["Q9NRP0-1","oligosaccharyltransferase complex subunit OSTC [OS=Homo sapiens]",13,2,19,2,149,16.8,9.13,58.98,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","DC2; OSTC","ENSANAG00000024765; ENSCANG00000031432; ENSCATG00000035272; ENSCCAG00000023668; ENSCJAG00000042857; ENSG00000198856; ENSGGOG00000026873; ENSMFAG00000034553; ENSMLEG00000037144; ENSMMUG00000011902; ENSNLEG00000012929; ENSOGAG00000033684; ENSPANG00000016693; ENSPPAG00000043858; ENSPTRG00000024222; ENSRBIG00000031965; ENSRROG00000031431","","","",1422.8,1392.3,1392.2,1141.9,1183.3,1490.4,1.1026575112695252,0.14098475509919683,0.3023936222128662,0.5194273727838208,0.5524106435275778,0.25773796227884505,4001]
["Q9NRR8","CDC42 small effector protein 1 [OS=Homo sapiens]",10,1,1,1,79,8.9,9.99,2.02,"transport;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","CDC42SE1","ENSG00000197622","","","",52.4,52.1,44.6,64.4,81.8,244.7,0.3814274750575595,-1.3905193270058482,0.233463440391606,0.6317811188636678,0.4940313508460475,0.3062454902111349,3454]
["Q9NRX2","39S ribosomal protein L17, mitochondrial [OS=Homo sapiens]",9,2,4,2,175,20,10.11,9.19,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL17","ENSG00000158042","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",620.5,592.8,844.2,738.5,868.6,1117.5,0.7551567202525142,-0.40515201194913963,0.17921817149679134,0.7466179579513234,0.4373641453990143,0.35915682279268063,2995]
["Q9NS00-1","Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 [OS=Homo sapiens]",18,6,13,6,363,42.2,6.64,40.84,"protein metabolism;other metabolic processes;developmental processes;other biological processes","other membranes;ER/Golgi","other molecular function","C1GALT1","ENSG00000106392","Mucin type O-glycan biosynthesis; Other types of O-glycan biosynthesis; Metabolic pathways","O-linked glycosylation of mucins; Defective C1GALT1C1 causes TNPS","Ectoderm differentiation",1101.8,1143.9,1088.8,1153.8,1181.2,3274.5,0.5944380069524914,-0.7504017335719008,0.3411649357374256,0.4670356111454416,0.5772163229872324,0.2386613960763808,4320]
["Q9NS69","Mitochondrial import receptor subunit TOM22 homolog [OS=Homo sapiens]",63,5,47,5,142,15.5,4.34,200.86,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity","TOMM22","ENSG00000100216","","Mitochondrial protein import; PINK1-PRKN Mediated Mitophagy","",3284.4,3259.7,3164.3,2740,3276,3195.1,1.0539892086721456,0.07586009593634217,0.3867336386282145,0.4125880507476345,0.6001350668224246,0.22175099599255774,4710]
["Q9NSD4","zinc finger protein 275 [OS=Homo sapiens]",3,1,1,1,429,48.4,9.09,2.04,"other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF275","ENSG00000063587","","","",126.8,145.1,121,275.1,276.2,226.4,0.5052076636235053,-0.9850515709880091,2.030711324246618E-3,2.6923518093363734,0.05913334290405789,1.2281675689334386,251]
["Q9NSG2-1","Uncharacterized protein C1orf112 [OS=Homo sapiens]",4,2,2,2,853,96.5,6,6.63,"","","","C1orf112","ENSG00000000460","","","",69.3,68.8,60.3,67.3,76.5,696.2,0.23619047619047617,-2.08197730216661,0.36224531152778094,0.44099722681135,0.5883668848792335,0.23035177870272078,4500]
["Q9NSY1","BMP-2-inducible protein kinase [OS=Homo sapiens]",8,6,8,6,1161,129.1,6.51,19.35,"protein metabolism;other metabolic processes;other biological processes","nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","BMP2K","ENSG00000138756","Transcriptional misregulation in cancer","","",682.1,684.4,704,777.9,781.7,678.7,0.925032390653621,-0.11242421140197828,0.17954604030798849,0.7458241683232227,0.4374340028703626,0.3590874611589122,3000]
["Q9NTN3","UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter [OS=Homo sapiens]",2,1,3,1,355,39.2,8.97,6.69,"transport","other membranes;ER/Golgi","transporter activity","SLC35D1","ENSG00000116704","","Formation of the active cofactor, UDP-glucuronate; Transport of nucleotide sugars; Defective SLC35D1 causes SCHBCKD","",323.4,307.1,298.4,327.3,320.9,389.7,0.894980248578861,-0.16007225116047735,0.19139919633280983,0.7180598901169535,0.4501083416977178,0.34668293836185715,3108]
["Q9NTX7","E3 ubiquitin-protein ligase rnf146 [OS=Homo sapiens]",9,3,3,3,359,38.9,5.33,4.98,"cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","RNF146","ENSG00000118518","","Degradation of AXIN; Ub-specific processing proteases; Regulation of PTEN stability and activity","",207,222.4,202.2,165.1,168,286.6,1.0192028400839113,0.027441202888626563,0.9266653448878683,0.033077078270990275,0.9523336622307972,0.0212108643491746,7112]
["Q9NUL5","Repressor of yield of DENV protein [OS=Homo sapiens]",4,1,3,1,291,33.1,7.25,8.25,"stress response;other biological processes","cytosol;nucleus;other cell component","translation activity;nucleic acid binding activity;other molecular function","SHFL","ENSG00000130813","","","",321.4,315.6,311.2,306.5,323.5,516.2,0.8272552783109405,-0.27359550318941017,0.3823432721660142,0.4175465473918344,0.5975084405091721,0.22365595541636557,4677]
["Q9NUQ2","1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [OS=Homo sapiens]",35,12,28,12,364,42,9.1,77.29,"other metabolic processes;developmental processes","other membranes;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","AGPAT5","ENSG00000155189; ENSG00000284980","Glycerolipid metabolism; Glycerophospholipid metabolism; Metabolic pathways; Phospholipase D signaling pathway","Synthesis of PA","Triacylglyceride synthesis",2902,2947.2,2921.8,2689.9,2644.4,2252.9,1.1560259384226061,0.2091737687848187,0.047235444611017176,1.3257319924237356,0.23728100664049795,0.6247370238616887,1455]
["Q9NUQ3-1","Gamma-taxilin [OS=Homo sapiens]",22,10,16,9,528,60.5,7.52,45.14,"cell cycle OR cell proliferation;other biological processes","other membranes;cytosol;nucleus","other molecular function","TXLNG","ENSG00000086712","","","",1264.1,1292.8,1505.5,1844.5,1739.6,825.1,0.9213462759684296,-0.1181846185575906,0.7456622544266026,0.1274578404270318,0.8369234363642565,0.07731427042420368,6512]
["Q9NUU7","ATP-dependent RNA helicase DDX19A [OS=Homo sapiens]",49,21,55,4,478,53.9,6.58,145.47,"other metabolic processes;transport","nucleus;other cell component","nucleic acid binding activity;other molecular function","DDX19A","ENSG00000168872","Nucleocytoplasmic transport; mRNA surveillance pathway","","",7488.6,7023.8,7431.5,7095.5,7217,6640.4,1.0472965556080542,0.06667001793753154,0.22180688850819294,0.6540249703841465,0.48263963920999764,0.3163770123418379,3359]
["Q9NUY8","TBC1 domain family member 23 [OS=Homo sapiens]",16,8,13,8,699,78.3,5.41,44.18,"cell organization and biogenesis;transport;developmental processes","cytosol;ER/Golgi;other cell component","","TBC1D23","ENSG00000036054","","","",700.1,744.7,735.9,707,665.3,937,0.9443121292166458,-0.08266429372887603,0.6427247711299335,0.19197496170819706,0.7696060537661671,0.11373152477104818,6104]
["Q9NV96","Cell cycle control protein 50A [OS=Homo sapiens]",24,7,26,7,361,40.7,8.59,87.23,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","transporter activity","TMEM30A","ENSG00000112697","","Neutrophil degranulation","",2469,2505.7,2891.3,2430.2,2639.5,2131.8,1.0922724432409914,0.1273327495631601,0.32988821237663063,0.4816332024638857,0.5714986831620747,0.24298476596179372,4219]
["Q9NVG8","TBC1 domain family member 13 [OS=Homo sapiens]",26,9,11,9,400,46.5,5.24,34.76,"transport;other biological processes","other membranes;cytosol","enzyme regulator activity;other molecular function","TBC1D13","ENSG00000107021","","TBC/RABGAPs","",1095.6,1063.6,1060.4,1000.8,1057,1085.8,1.0241761038300037,0.03446380350023342,0.4070800933114516,0.39032013460505216,0.6112055057546014,0.2138127422791066,4868]
["Q9NVH2","Integrator complex subunit 7 [OS=Homo sapiens]",13,8,13,8,962,106.8,8.02,34.41,"RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","","INTS7","ENSG00000143493","","RNA polymerase II transcribes snRNA genes","",684.5,747.6,713.4,856.6,824.4,764.6,0.8772898266274125,-0.18887455625122201,0.03715365269681652,1.4299984828969592,0.21149224887930837,0.6747055447458207,1284]
["Q9NVM6","DnaJ homolog subfamily C member 17 [OS=Homo sapiens]",2,1,1,1,304,34.7,8.53,2.12,"transport;other biological processes","nucleus;other cell component","nucleic acid binding activity","DNAJC17","ENSG00000104129","","","",63.5,61.1,87.5,119.1,137.2,193.4,{"$f":"AVERAGE(S6402:U6402)/AVERAGE(V6402:X6402)","v":0.47164776517678464},{"$f":"LOG(Y6402,2)","v":-1.0842182631384605},{"$f":"TTEST(V6402:X6402,S6402:U6402,2,2)","v":0.02956452216949881},1.5292291358032803,{"$f":"AA6402*7309/AE6402","v":0.19259099156583495},0.7153640308394499,1122]
["Q9NVS2","39S ribosomal protein S18a, mitochondrial [OS=Homo sapiens]",18,3,8,3,196,22.2,10.33,26.3,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPS18A","ENSG00000096080","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",760.1,740.7,834.8,728.7,660.4,655.2,1.1424937631463095,0.19218628965756848,0.059394525283179414,1.2262535844612605,0.2630997486634899,0.5798795667911939,1650]
["Q9NVS9","Pyridoxine-5'-phosphate oxidase [OS=Homo sapiens]",41,7,19,7,261,30,7.06,69.9,"other metabolic processes","cytosol","other molecular function","PNPO","ENSG00000108439","Vitamin B6 metabolism; Metabolic pathways; Biosynthesis of cofactors","Vitamins B6 activation to pyridoxal phosphate","Selenium micronutrient network; Vitamin B6-dependent and responsive disorders",2464.1,1972.8,2141.1,2697.9,3014.2,4712,0.6310376915033431,-0.6642019157952889,0.11642038944759373,0.9339709522538693,0.36332904631616675,0.43969988110624064,2342]
["Q9NVX7-1","Kelch repeat and BTB domain-containing protein 4 [OS=Homo sapiens]",5,2,2,2,518,58.1,5.67,7.11,"","","","KBTBD4","ENSG00000123444; ENSG00000284900","","","",47.3,52.8,56.1,55.2,50.6,73.6,0.8706800445930879,-0.1997854367772822,0.35964667732277333,0.4441239476725249,0.5880665692510403,0.23057350892048842,4470]
["Q9NW13-1","RNA-binding protein 28 [OS=Homo sapiens]",31,21,47,20,759,85.7,9.22,121.73,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity","RBM28","ENSG00000106344","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol","",6287.4,5835.1,6268,9041.4,8969.1,10863.1,0.6369313144187078,-0.6507902917783036,5.377966669550014E-3,2.2693818936849306,0.09015495043059875,1.0450104210695437,436]
["Q9NW82","WD repeat-containing protein 70 [OS=Homo sapiens]",26,16,25,16,654,73.2,6.33,58.75,"other biological processes","nucleus;other cell component","other molecular function","WDR70","ENSG00000082068","","","",2683.1,2646.9,2589.6,2913.7,2924.1,3248.1,0.8716362715856437,-0.1982018620086541,0.02635609561605455,1.5791189255648734,0.18434134244760067,0.7343772541279733,1045]
["Q9NWS8","Required for meiotic nuclear division protein 1 homolog [OS=Homo sapiens]",10,4,4,4,449,51.6,8.69,9.4,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","","RMND1","ENSG00000155906","","","",324.4,353.3,305.1,272,238.5,379.1,1.1047661870503598,0.14374106963865746,0.5249107100309863,0.2799145660013269,0.6847353881164517,0.1644772265849223,5603]
["Q9NWV4","UPF0587 protein C1orf123 [OS=Homo sapiens]",71,7,29,7,160,18,5.01,88.76,"","","other molecular function","CZIB","ENSG00000162384","","","",3936.9,3644.4,4127,4276.2,4756,2372.8,1.0265935992985533,0.0378651706396682,0.8980870354336046,0.046681572935261206,0.9339951824109585,0.029655363874545582,7028]
["Q9NWY4","Histone PARylation factor 1 [OS=Homo sapiens]",28,10,19,10,346,39.4,6.8,59.54,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","other molecular function","HPF1","ENSG00000056050","","","",2733.5,2768.6,2682.6,2934.3,2989.8,2963.4,0.9209226441631506,-0.1188481172561058,1.3911271543068148E-3,2.856633172028116,0.051876267198104634,1.2850312815006193,196]
["Q9NX14-1","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [OS=Homo sapiens]",44,5,28,5,153,17.3,5.22,75.73,"cell organization and biogenesis","other membranes;mitochondrion","","NDUFB11","ENSG00000147123","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Nonalcoholic fatty liver disease",2972.4,2941.6,3020.9,2992.6,3305.4,3821.9,0.882903981264637,-0.17967154635182614,0.17922767801521422,0.746594921676808,0.43724135467730335,0.3592787688202638,2996]
["Q9NX20","39S ribosomal protein L16, mitochondrial [OS=Homo sapiens]",35,8,24,8,251,28.4,10.13,68.39,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL16","ENSG00000166902","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",5102.8,4421.3,4845.5,4468.8,4933,5423.2,0.9692816188870151,-0.04501220206080415,0.6781088247693571,0.16870060376677784,0.7917407987602606,0.10141697509323452,6260]
["Q9NX63","MICOS complex subunit MIC19 [OS=Homo sapiens]",52,16,78,16,227,26.1,8.28,211.32,"cell organization and biogenesis","other membranes;mitochondrion;nucleus","other molecular function","CHCHD3","ENSG00000106554","","Mitochondrial protein import; Cristae formation","",9029.7,8708.5,11824.6,11986.4,12012.6,9566.3,0.8807548271578088,-0.18318761815883697,0.3559366846361093,0.4486272491021059,0.5869903492791794,0.23136903893850624,4432]
["Q9NX78","Transmembrane protein 260 [OS=Homo sapiens]",4,2,4,2,707,79.5,8.4,13.94,"","other membranes","","TMEM260","ENSG00000070269","","","",243,229.5,221.8,156,172.6,204.9,1.301405810684161,0.38007090038886204,0.026587686671988655,1.5753194478995578,0.1847237660509174,0.7334772258333051,1052]
["Q9NXF7","DDB1- and CUL4-associated factor 16 [OS=Homo sapiens]",7,1,2,1,216,24.2,6.04,8.54,"protein metabolism;other metabolic processes","nucleus;other cell component","","DCAF16","ENSG00000163257","","Neddylation","",169.4,154.3,160.3,229.2,232.1,187.9,0.7455329636475664,-0.42365595238601433,0.021068930083589385,1.676357518050709,0.16611953611753486,0.7795792903112333,927]
["Q9NXR7-1","Isoform 1 of BRISC and BRCA1-A complex member 2 [OS=Homo sapiens]",11,4,10,4,415,46.9,6.14,26.99,"","","","BABAM2","","","","",1017.7,970.8,1046.2,1028.1,1062.9,648,1.1079591091639285,0.14790463761903633,0.5048427016830623,0.2968439177873195,0.6715005107555054,0.17295365266285592,5495]
["Q9NXX6","Non-structural maintenance of chromosomes element 4 homolog A [OS=Homo sapiens]",12,4,6,4,385,44.3,5.38,9.92,"DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","","NSMCE4A","ENSG00000107672","","SUMOylation of DNA damage response and repair proteins","",197.4,184,196.3,222.1,226.9,149.5,0.9652464494569759,-0.05103075249073857,0.7984240579658495,0.09776638544262867,0.8724295768683501,0.05926961951128904,6689]
["Q9NY35-1","Claudin domain-containing protein 1 [OS=Homo sapiens]",14,3,7,3,253,28.6,5.82,21.12,"","plasma membrane;other membranes","","CLDND1","ENSCANG00000033095; ENSG00000080822; ENSGGOG00000007565; ENSPPYG00000013614","","","",535.3,503.2,490.9,418.4,460.1,392.7,1.2031151667715545,0.266774749394839,0.022076830900972847,1.6560632688504457,0.16931747854691556,0.7712982076047992,953]
["Q9NYG2-1","Palmitoyltransferase ZDHHC3 [OS=Homo sapiens]",3,1,2,1,299,34.1,8.18,3.48,"protein metabolism;other metabolic processes;transport;signal transduction;other biological processes","other membranes;ER/Golgi","other molecular function","ZDHHC3","ENSCCAG00000029642; ENSG00000163812","","","",111.4,109.4,90.6,101,92.3,252.3,0.6988330341113106,-0.5169802882609947,0.44110301608983643,0.35545997267569673,0.6295688233939883,0.20095678662611985,5121]
["Q9NYH9","U3 small nucleolar RNA-associated protein 6 homolog [OS=Homo sapiens]",20,10,15,10,597,70.1,7.28,50.5,"RNA metabolism OR transcription;other metabolic processes","nucleus;other cell component","nucleic acid binding activity","UTP6","ENSG00000108651","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",1232.9,1388,1294.7,2099.6,1986.2,1642.5,0.6835535848331966,-0.5488736575052605,0.013942489802636468,1.8556596644738645,0.13715431758744273,0.8627905163504669,743]
["Q9NYP7-1","elongation of very long chain fatty acids protein 5 [OS=Homo sapiens]",3,1,11,1,299,35.3,9.42,23.14,"other metabolic processes;other biological processes","other membranes;ER/Golgi;other cell component","other molecular function","ELOVL5","ENSG00000012660; ENSGGOG00000011386; ENSPPAG00000035952; ENSPTRG00000018289","Fatty acid elongation; Biosynthesis of unsaturated fatty acids; Metabolic pathways; Fatty acid metabolism","Synthesis of very long-chain fatty acyl-CoAs; alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism","Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Linoleic acid metabolism affected by coronavirus infection",2091,1809.2,2085.2,1949,2099,783.4,1.238854162354597,0.3090063637243668,0.41766495090902084,0.37917196779321005,0.6175830722626003,0.20930461637001388,4943]
["Q9NYU2-1","UDP-glucose:glycoprotein glucosyltransferase 1 [OS=Homo sapiens]",46,53,322,53,1555,177.1,5.63,1048.08,"protein metabolism;other metabolic processes;stress response;other biological processes","ER/Golgi;other cell component","other molecular function","UGGT1","ENSG00000136731","Protein processing in endoplasmic reticulum","ER Quality Control Compartment (ERQC)","IL-18 signaling pathway",30504.3,31600.3,31176.7,28775.3,28188.4,27790.3,1.1006123604785616,0.1383064361249866,2.6811744496124746E-3,2.571674927889823,0.06576075185307911,1.182033230082105,298]
["Q9NZ09-1","Ubiquitin-associated protein 1 [OS=Homo sapiens]",25,9,16,9,502,55,5.11,48.67,"protein metabolism;other metabolic processes;transport","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","UBAP1","ENSG00000165006","","HCMV Late Events; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy","",1324.4,1377,1339.6,1845.5,1822.9,1944.1,0.7200000000000001,-0.47393118833241216,2.0329659147352497E-4,3.691869902801455,0.023585631540952286,1.6273524903710637,63]
["Q9NZB2-1","Constitutive coactivator of PPAR-gamma-like protein 1 [OS=Homo sapiens]",34,34,120,34,1118,121.8,8.88,407.71,"","plasma membrane;other membranes;cytosol;nucleus","","FAM120A","ENSG00000048828; ENSRROG00000028506","","","VEGFA-VEGFR2 signaling pathway",13173.1,13783.5,13241.3,14975.1,14645.7,20396.3,0.8036831403659945,-0.31530127746954717,0.15570129864588517,0.8077077651300825,0.4118786796246018,0.38523068816262085,2763]
["Q9NZJ4-1","Sacsin [OS=Homo sapiens]",1,4,4,4,4579,520.8,7.05,13.72,"other biological processes","mitochondrion;nucleus;other cell component","other molecular function","SACS","ENSG00000151835","","","",232.3,211.1,217.4,190.3,224.6,452.3,0.7619926199261993,-0.39215106993442617,0.4509917289604387,0.3458314228665617,0.6356148374415439,0.1968059734159214,5186]
["Q9NZJ7","Mitochondrial carrier homolog 1 [OS=Homo sapiens]",6,2,9,2,389,41.5,9.32,23.47,"cell organization and biogenesis;developmental processes;other biological processes","other membranes;mitochondrion","","MTCH1","ENSG00000137409","","","IL-18 signaling pathway",747.4,791.1,740.4,698.1,695.6,1375.5,0.8229452549472772,-0.28113163391608464,0.510969869366025,0.2916047083855923,0.6759599593115433,0.17007902885876763,5525]
["Q9NZM4","BRD4-interacting chromatin-remodeling complex-associated protein [OS=Homo sapiens]",1,1,1,1,1560,158.4,6.65,2.78,"other biological processes","nucleus","other molecular function","BICRA","ENSG00000063169","","","",16.5,24.9,16.7,23.6,20.7,14.7,0.9847457627118642,-0.022176790844675043,0.9410401877500911,0.02639182934062665,0.9619668157014568,0.016839909257734292,7150]
["Q9NZN8-1","CCR4-NOT transcription complex subunit 2 [OS=Homo sapiens]",16,8,13,8,540,59.7,7.66,30.49,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","Cnot2; CNOT2; LOC111142051","ENSAMEG00000011938; ENSBIXG00000020780; ENSBIXG00005028198; ENSBMUG00000006457; ENSBTAG00000003748; ENSCAFG00000000441; ENSCANG00000037683; ENSCATG00000036994; ENSCCAG00000033920; ENSCSAG00000004177; ENSDLEG00000001866; ENSFCAG00000024278; ENSG00000111596; ENSGGOG00000027402; ENSLAFG00000004789; ENSLCNG00005003598; ENSMFAG00000034373; ENSMLEG00000041145; ENSMMUG00000014853; ENSMNEG00000045426; ENSMPUG00000017494; ENSPANG00000018112; ENSPCTG00005004059; ENSPPAG00000042482; ENSPTRG00000005216; ENSRBIG00000039989; ENSRFEG00010003667; ENSRROG00000042572; ENSSBOG00000026423; ENSSSUG00005015658; ENSUMAG00000020863","RNA degradation","Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain","",1397.4,1428.5,1493.9,1689.7,1572,1082.8,0.9943146507077915,-8.225630239888853E-3,0.9671638183740809,0.014499958812297086,0.9803079113155121,0.008637492489248104,7211]
["Q9P015","39S ribosomal protein L15, mitochondrial [OS=Homo sapiens]",40,10,20,10,296,33.4,10.01,72.38,"protein metabolism;other metabolic processes;other biological processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPL15","ENSG00000137547","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",2232.7,2273.7,2485.2,2195.5,2298.5,2305.9,1.0281915910528097,0.04010911833293476,0.4985744850524649,0.30226995063059126,0.666681469310001,0.17608161610326017,5466]
["Q9P0J1","[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial [OS=Homo sapiens]",7,3,6,3,537,61,6.67,16.84,"protein metabolism;other metabolic processes;other biological processes","mitochondrion","other molecular function","PDP1","ENSG00000164951","","Regulation of pyruvate dehydrogenase (PDH) complex","Orexin receptor pathway",391.3,482.8,447,384.7,304.2,905.6,0.8285355910943869,-0.27136442279669193,0.6571139307365529,0.18235932572093916,0.7800626473531697,0.10787051742844789,6157]
["Q9P0L0","vesicle-associated membrane protein-associated protein A [OS=Homo sapiens]",67,14,116,2,249,27.9,8.62,298.47,"cell organization and biogenesis;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","VAPA","ENSG00000101558","Cholesterol metabolism","Neutrophil degranulation; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; Sphingolipid de novo biosynthesis","Exercise-induced circadian regulation",19226.7,19105.1,17680.9,17705.1,19234.7,23910.2,0.9205045193097783,-0.1195032902379817,0.45073187382221075,0.3460817294026274,0.6354936855259526,0.19688876038119135,5184]
["Q9P0U4","CXXC-type zinc finger protein 1 [OS=Homo sapiens]",14,8,9,8,656,75.7,8.24,25.33,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","CXXC1","ENSG00000154832","","XBP1(S) activates chaperone genes","Male infertility",441.3,458.9,445.8,486.4,491.9,510.8,0.9039016855818952,-0.14576223091590346,0.006286116095022037,2.2016176024845446,0.09611971242367377,1.0171875372126906,478]
["Q9P1Y6-1","PHD and RING finger domain-containing protein 1 [OS=Homo sapiens]",7,11,18,10,1649,178.6,8.95,39.76,"RNA metabolism OR transcription;other metabolic processes","","other molecular function","KIAA1542; PHRF1","ENSG00000070047; ENSG00000274780","","","",1575.1,1547.1,1513.1,1434.1,1541.9,1609.4,1.0108823657696164,0.015615123655522398,0.7738575064435047,0.11133900037968568,0.8553038733699647,0.06787956119969432,6613]
["Q9P206","Uncharacterized protein KIAA1522 [OS=Homo sapiens]",2,1,2,1,1035,107,9.73,8.5,"other biological processes","","","KIAA1522","ENSG00000162522","","","",13,14.5,17.8,8.4,13,19.1,1.1185185185185185,0.16158914227424795,0.6631579040854301,0.1783830497129833,0.7836735846338575,0.10586479179414979,6185]
["Q9P275","Ubiquitin carboxyl-terminal hydrolase 36 [OS=Homo sapiens]",3,4,6,4,1121,122.6,9.67,13.86,"","","","","","","","",286.5,307.9,293.5,529.1,609.7,529.3,0.5322822372759426,-0.9097366718166927,7.0351436321519894E-4,3.152727031418396,0.036992708494531575,1.4318838697885181,139]
["Q9P287","BRCA2 and CDKN1A-interacting protein [OS=Homo sapiens]",37,10,30,10,314,36,4.61,75.8,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus","enzyme regulator activity;cytoskeletal activity","BCCIP","ENSG00000107949","","","",3328.3,3165,3272.1,3395.1,3431.7,2737.9,1.020983407738873,0.02995942080204973,0.7860111940884914,0.10457126885086755,0.8636433880927216,0.0636655475143762,6652]
["Q9P2E9-1","Ribosome-binding protein 1 [OS=Homo sapiens]",74,90,756,2,1410,152.4,8.6,2319.83,"","","","","","","","",83981.2,85858.4,86412.3,98845.2,102195.2,115150.4,0.8104343959406788,-0.3032326895044831,0.0164642983487577,1.7834567726809396,0.14948764798890685,0.8253946911648353,805]
["Q9P2K5-1","Myelin expression factor 2 [OS=Homo sapiens]",8,6,16,6,600,64.1,8.75,44.33,"stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","MYEF2","ENSG00000104177","","","Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Mitochondrial gene expression",1922.5,2617.4,1875.8,2748.8,2154.6,2391.6,0.8794653872515422,-0.18530129561330588,0.3774167177442108,0.4231788665895895,0.5946408256073371,0.22574527722437612,4639]
["Q9P2M7-1","cingulin [OS=Homo sapiens]",18,23,34,23,1197,136.3,5.54,88.33,"","plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity","CGN","ENSG00000143375","Tight junction","TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)","",2392.1,2449.8,2439,3284.1,3374.8,4248.9,0.6674948202203929,-0.5831714534000498,0.017192151868289908,1.764669761123583,0.15176019082769437,0.8188421360244903,828]
["Q9P2X0-1","Dolichol-phosphate mannosyltransferase subunit 3 [OS=Homo sapiens]",24,2,11,2,92,10.1,5.94,36.9,"protein metabolism;other metabolic processes;other biological processes","other membranes;ER/Golgi;other cell component","enzyme regulator activity","DPM3","ENSG00000179085","N-Glycan biosynthesis; Metabolic pathways","Synthesis of dolichyl-phosphate mannose; Defective DPM1 causes DPM1-CDG (CDG-1e); Defective DPM3 causes DPM3-CDG (CDG-1o); Defective DPM2 causes DPM2-CDG (CDG-1u)","",1020.9,1352.3,1278.7,984.5,1168.3,1177.9,1.0964361845858228,0.13282184588222393,0.41753162945098254,0.37931061963973023,0.6177608663273748,0.2091796066794042,4940]
["Q9UBC2-2","Isoform 2 of Epidermal growth factor receptor substrate 15-like 1 [OS=Homo sapiens]",37,29,73,2,910,99.5,5.08,234.54,"","","","EPS15L1","","","","",6285.9,6273.8,6125.9,6578.5,7071.1,6379.2,0.9329365713372743,-0.10014909669117815,0.10222476033805475,0.9904438989588292,0.34179358339928734,0.4662360946885402,2186]
["Q9UBD5-1","Origin recognition complex subunit 3 [OS=Homo sapiens]",22,13,21,12,711,82.2,7.61,48.09,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","ORC3","ENSG00000135336","Cell cycle","CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Assembly of the ORC complex at the origin of replication; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation","Cell cycle; G1 to S cell cycle control; DNA replication",1472.9,1332.9,1346.9,1364.7,1418.2,1248.2,1.0301654635211235,0.042876079378848006,0.5782987126218586,0.23784777449883535,0.721787105627248,0.14159088066519784,5856]
["Q9UBM7","7-dehydrocholesterol reductase [OS=Homo sapiens]",23,11,81,11,475,54.5,8.7,186.98,"other metabolic processes;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","DHCR7","ENSG00000172893","Steroid biosynthesis; Metabolic pathways","Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis via desmosterol; Cholesterol biosynthesis via lathosterol","Vitamin D metabolism; Cholesterol biosynthesis pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias",10158.7,10317.6,9911.2,9074,9042.4,9645.7,1.0945677740516748,0.13036128687251433,0.01873846086572571,1.727266083937752,0.1581517441889021,0.8009260140711256,866]
["Q9UBQ7","Glyoxylate reductase/hydroxypyruvate reductase [OS=Homo sapiens]",35,10,41,10,328,35.6,7.39,118.2,"other metabolic processes;other biological processes","cytosol;other cytoplasmic organelle;other cell component","other molecular function","GRHPR","ENSG00000137106","Glycine, serine and threonine metabolism; Pyruvate metabolism; Glyoxylate and dicarboxylate metabolism; Metabolic pathways","Glyoxylate metabolism and glycine degradation","",4126.7,4359,4157,4041.3,3994,4479.8,1.010195683614194,0.014634782516577348,0.8157939323872803,0.08841952914949802,0.8842707773718865,0.05341472694216518,6743]
["Q9UBS0","Ribosomal protein S6 kinase beta-2 [OS=Homo sapiens]",20,4,6,4,482,53.4,7.34,21.13,"protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus;other cell component","kinase activity;other molecular function","RPS6KB2","ENSG00000175634","EGFR tyrosine kinase inhibitor resistance; Endocrine resistance; ErbB signaling pathway; HIF-1 signaling pathway; Autophagy; mTOR signaling pathway; PI3K-Akt signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; TGF-beta signaling pathway; Apelin signaling pathway; Fc gamma R-mediated phagocytosis; Thermogenesis; Insulin signaling pathway; Insulin resistance; Shigellosis; Human cytomegalovirus infection; Human papillomavirus infection; Human immunodeficiency virus 1 infection; Pathways in cancer; Proteoglycans in cancer; Chemical carcinogenesis; Colorectal cancer; Pancreatic cancer; Acute myeloid leukemia; Breast cancer; Hepatocellular carcinoma; Gastric cancer; Choline metabolism in cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer","Constitutive Signaling by AKT1 E17K in Cancer; AKT phosphorylates targets in the nucleus","IL-5 signaling pathway; AMP-activated protein kinase (AMPK) signaling; Follicle stimulating hormone (FSH) signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Thermogenesis; Translation inhibitors in chronically activated PDGFRA cells; Head and neck squamous cell carcinoma; Cytoplasmic ribosomal proteins; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; Malignant pleural mesothelioma; ErbB signaling pathway",288,288.2,261.7,267,302.6,319.1,0.9428378530437718,-0.08491841383187784,0.39323535842666274,0.40534743875651275,0.6035609480765388,0.2192788679414009,4762]
["Q9UBU6","Protein FAM8A1 [OS=Homo sapiens]",13,2,4,2,413,44.1,7.21,15.08,"protein metabolism;other metabolic processes;stress response","other membranes;ER/Golgi","","FAM8A1","ENSG00000137414","","","",192.7,200.5,188.8,198.5,221.7,232.1,0.8922275026828148,-0.16451647538765446,0.08964949636588868,1.0474521458801567,0.3224646500680513,0.4915178876080654,2032]
["Q9UBV2","Protein sel-1 homolog 1 [OS=Homo sapiens]",22,13,47,13,794,88.7,5.39,129.68,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;ER/Golgi","","SEL1L","ENSG00000071537","Protein processing in endoplasmic reticulum","ABC-family proteins mediated transport; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Defective CFTR causes cystic fibrosis; ER Quality Control Compartment (ERQC); Pre-NOTCH Processing in Golgi","Genotoxicity pathway; Familial  hyperlipidemia type 1; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5",2759.1,2643.2,2488,2729.8,2845.4,1926.2,1.0518436558509079,0.07292028096964041,0.6874950275027611,0.1627304386408587,0.7982368794309264,0.09786821120076712,6295]
["Q9UDW1","cytochrome b-c1 complex subunit 9 [OS=Homo sapiens]",38,2,6,2,63,7.3,9.47,16.43,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","UQCR10","ENSG00000184076","Oxidative phosphorylation; Metabolic pathways; Cardiac muscle contraction; Thermogenesis; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Respiratory electron transport","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly",815.9,1153,1256.5,809.2,859.4,551,1.4531447107586954,0.5391783802579402,0.11004316630131716,0.9584369220318385,0.3515321252169262,0.45403498026885214,2288]
["Q9UER7-1","Death domain-associated protein 6 [OS=Homo sapiens]",7,6,13,6,740,81.3,4.87,27.33,"cell organization and biogenesis;stress response;signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","DAXX","ENSG00000204209; ENSG00000206206; ENSG00000206279; ENSG00000227046; ENSG00000231617","MAPK signaling pathway; Apoptosis; Parkinson disease; Amyotrophic lateral sclerosis; Pathways of neurodegeneration; Herpes simplex virus 1 infection","HCMV Early Events; Inhibition of DNA recombination at telomere; Regulation of TP53 Degradation; SUMOylation of transcription cofactors; Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations; Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations","Androgen receptor signaling pathway; Amyotrophic lateral sclerosis (ALS); Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; p38 MAPK signaling pathway",1701.3,1668.6,1639.2,2004.1,2021.9,1567.1,0.8955856322969371,-0.15909671138223178,0.2636028805566069,0.5790498482396216,0.5204412355451756,0.2836283007725338,3702]
["Q9UEW8","STE20/SPS1-related proline-alanine-rich protein kinase [OS=Homo sapiens]",22,11,31,9,545,59.4,6.29,89.07,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","STK39","ENSG00000198648","","","",2584.9,2538.8,2464.5,2496.9,2392,1922,1.1141258864467252,0.15591225376549056,0.22387564613531594,0.6499931477086415,0.4838282370204093,0.31530878908639143,3382]
["Q9UFW8","CGG triplet repeat-binding protein 1 [OS=Homo sapiens]",25,3,3,3,167,18.8,8.95,11.39,"cell organization and biogenesis;other biological processes","nucleus","nucleic acid binding activity;other molecular function","CGGBP1","ENSG00000163320","","","",387.1,377.5,338.3,383.7,354.4,353.2,1.0106295244204162,0.015254232419319277,0.8399936484659543,0.07572399780313797,0.8989038911621756,0.04628673960069759,6830]
["Q9UG63","ATP-binding cassette sub-family F member 2 [OS=Homo sapiens]",38,26,112,26,623,71.2,7.37,269.11,"transport","","transporter activity;other molecular function","ABCF2","ENSG00000033050","Pathogenic Escherichia coli infection","","VEGFA-VEGFR2 signaling pathway",14761.2,14889.9,14843.8,17046.7,16816.5,13743.9,0.9346273980141616,-0.09753676536729343,0.3852958859789988,0.4142056281688263,0.5993036030262827,0.2223531113078051,4699]
["Q9UGP4","LIM domain-containing protein 1 [OS=Homo sapiens]",34,15,32,15,676,72.1,6.65,121.56,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","LIMD1","ENSG00000144791","Hippo signaling pathway; Hippo signaling pathway","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha","Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Malignant pleural mesothelioma",3213.8,3172.6,3039.6,3581.3,3726.7,2844.1,0.9284778518730115,-0.10706059869982226,0.4334269671453915,0.3630840710547624,0.6244663321241211,0.2044909714881937,5073]
["Q9UGU5","HMG domain-containing protein 4 [OS=Homo sapiens]",7,3,3,3,601,65.7,9.32,9.13,"cell-cell signaling;transport;signal transduction;other biological processes","nucleus","nucleic acid binding activity;other molecular function","HMGXB4","ENSG00000100281","","","",149.8,165.1,142.6,167.2,147.2,135.5,1.0168926428095133,0.024167376479721187,0.8348419743823725,0.07839572349689154,0.8962779069860106,0.04755730868945007,6808]
["Q9UH17-1","DNA dC->dU-editing enzyme APOBEC-3B [OS=Homo sapiens]",21,6,14,4,382,45.9,6.06,42.85,"DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus;other cell component","other molecular function","APOBEC3B","ENSG00000179750","Human immunodeficiency virus 1 infection","Formation of the Editosome","",454.7,555.2,558.4,781.6,688.1,558.5,{"$f":"AVERAGE(S6722:U6722)/AVERAGE(V6722:X6722)","v":0.7732472142786708},{"$f":"LOG(Y6722,2)","v":-0.37099836405563696},{"$f":"TTEST(V6722:X6722,S6722:U6722,2,2)","v":0.10397879221428843},0.9830552315044423,{"$f":"AA6722*7309/AE6722","v":0.3438828019430924},0.46358954330557994,2210]
["Q9UHB7-1","AF4/FMR2 family member 4 [OS=Homo sapiens]",10,9,12,9,1163,127.4,9.31,24.62,"other biological processes","nucleus;other cell component","","AFF4","ENSG00000072364","","RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex","",624,649.1,629.5,510.8,527.4,689.4,1.1012965964343597,0.1392030616179733,0.3675414464290762,0.4346936798709247,0.5914487961140728,0.2280828478706681,4542]
["Q9UHG3","prenylcysteine oxidase 1 [OS=Homo sapiens]",29,12,37,12,505,56.6,6.18,118.54,"protein metabolism;other metabolic processes;transport","non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle","other molecular function","PCYOX1","ENSG00000116005","Terpenoid backbone biosynthesis","","",3975.6,4972.1,4901.4,3712.2,3092.6,3968.9,1.285454393569526,0.36227842593333515,0.06812909216502387,1.1666673980905078,0.2840590613999769,0.5465913523003297,1753]
["Q9UHJ6","Sedoheptulokinase [OS=Homo sapiens]",18,5,12,5,478,51.5,6.83,47.44,"other metabolic processes;other biological processes","cytosol;other cell component","kinase activity;other molecular function","SHPK","ENSG00000197417","Metabolic pathways","Pentose phosphate pathway","",812.5,916.7,912,811.1,678.7,3818.4,0.497569797671527,-1.007029177891336,0.4350206661915559,0.36149011086200167,0.6249147109265099,0.20417925161838613,5088]
["Q9UHQ4","B-cell receptor-associated protein 29 [OS=Homo sapiens]",37,12,28,12,241,28.3,9.54,66.24,"transport;other biological processes","other membranes;ER/Golgi","","BCAP29","ENSG00000075790; ENSG00000283852","","","",4303,4025,4109.4,4050.9,4329.4,3711.1,1.028615379525944,0.040703629675977133,0.5893369705882834,0.22963631366668144,0.7309458540691945,0.13611479287785763,5893]
["Q9UHW5-1","GPN-loop GTPase 3 [OS=Homo sapiens]",12,2,2,2,284,32.7,4.5,4.46,"","other cell component","other molecular function","GPN3","ENSG00000111231; ENSNLEG00000029104; ENSPPAG00000031515","","","",81.8,81.7,73.2,77.3,75.2,122.8,0.8597893207410098,-0.2179449038609465,0.4608299860997546,0.33645926922470365,0.6404651774868048,0.19350447815418811,5259]
["Q9UI09","NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [OS=Homo sapiens]",6,1,3,1,145,17.1,9.63,7.87,"cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","other membranes;cytosol;mitochondrion","transporter activity","NDUFA12","ENSG00000184752","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease",500.3,554.5,491.5,572.7,488.5,5215.5,0.24635556900919273,-2.021186009918275,0.36983769408270095,0.4319888273632925,0.5917565030758453,0.22785696071711123,4568]
["Q9UI32","Glutaminase liver isoform, mitochondrial [OS=Homo sapiens]",1,1,2,1,602,66.3,7.3,4.69,"other metabolic processes;other biological processes","mitochondrion","other molecular function","GLS2","ENSG00000135423","Arginine biosynthesis; Alanine, aspartate and glutamate metabolism; D-Amino acid metabolism; Metabolic pathways; Glutamatergic synapse; GABAergic synapse; Proximal tubule bicarbonate reclamation; MicroRNAs in cancer; Central carbon metabolism in cancer","TP53 Regulates Metabolic Genes; Glutamate and glutamine metabolism; Glutamate Neurotransmitter Release Cycle","p53 transcriptional gene network; Neuroinflammation and glutamatergic signaling",320,348,378.5,256.7,211.8,134,1.7369294605809127,0.7965391651383851,0.020206270102505128,1.6945138459798983,0.16301062712937084,0.7877840817727383,906]
["Q9UIA9","exportin-7 [OS=Homo sapiens]",31,26,75,26,1087,123.8,6.32,238.09,"transport","nucleus;other cell component","other molecular function","XPO7","ENSG00000130227","Nucleocytoplasmic transport","","",6401.4,6088.8,6713.1,5700,6001.3,7021.5,1.0256638964257485,0.03655804634494052,0.7334661140240498,0.13461994566843297,0.8287067286136621,0.0815991349249483,6469]
["Q9UII2-1","ATPase inhibitor, mitochondrial [OS=Homo sapiens]",24,4,10,4,106,12.2,9.35,31.07,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","mitochondrion;other cell component","enzyme regulator activity;other molecular function","ATP5IF1","ENSG00000130770; ENSG00000285390; ENSPPAG00000043083; ENSPPYG00000001644; ENSPTRG00000000428","","","Electron transport chain: OXPHOS system in mitochondria",970.4,996.5,851.4,680.2,661.7,675.3,1.3971346420781283,0.48247106018780667,4.042316528554888E-3,2.3933696826013837,0.07775076712423072,1.1092953173342208,380]
["Q9UJ04","testis-specific Y-encoded-like protein 4 [OS=Homo sapiens]",2,1,2,1,414,45.1,8.57,4.23,"cell organization and biogenesis","nucleus;other cell component","other molecular function","TSPYL4","ENSG00000187189","","","",280.6,283.5,257.1,228.9,231,79.7,1.5218680504077093,0.6058432791603344,0.13822817838958623,{"$f":"-LOG10(AA6787)","v":0.8594034151986767},0.39113811686004096,{"$f":"-LOG10(AC6787)","v":0.4076698594880209},2583]
["Q9UJ70","N-acetyl-D-glucosamine kinase [OS=Homo sapiens]",53,12,63,12,344,37.4,6.24,220.03,"other metabolic processes","cytosol","kinase activity;other molecular function","NAGK","ENSG00000124357","Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of nucleotide sugars","Synthesis of UDP-N-acetyl-glucosamine","",6009.3,6052.5,5798.4,6324.2,6202.2,5875.8,0.9705469998152393,-0.04313001614879238,0.30900395286345334,0.5100359649253104,0.5579322854444122,0.25341850687308015,4048]
["Q9UJF2","ras GTPase-activating protein nGAP [OS=Homo sapiens]",6,6,7,5,1139,128.5,8.24,17.53,"signal transduction;other biological processes","cytosol","enzyme regulator activity","RASAL2","ENSG00000075391","Ras signaling pathway","Regulation of RAS by GAPs; RND1 GTPase cycle; RND3 GTPase cycle","Ras signaling",219.4,205.4,208.8,258.2,279.6,347.2,0.7159322033898305,-0.4821051197781125,0.03669871048856497,1.4353491956263722,0.2105422880383998,0.6766606617417308,1274]
["Q9UJQ1-1","Lysosome-associated membrane glycoprotein 5 [OS=Homo sapiens]",9,2,5,2,280,31.5,6.46,17.09,"other biological processes","plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle","","LAMP5","ENSG00000125869","","","",359.5,352.8,332.6,462.5,462.6,243.1,0.8944530046224961,-0.16092241113357209,0.6063139175451896,0.21730246270070025,0.7425516795137049,0.12927331528133965,5968]
["Q9UJX4","Anaphase-promoting complex subunit 5 [OS=Homo sapiens]",17,8,16,8,755,85,6.87,43.29,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","ANAPC5","ENSG00000089053","Cell cycle; Oocyte meiosis; Ubiquitin mediated proteolysis; IL-17 signaling pathway; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection","Separation of Sister Chromatids; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Inactivation of APC/C via direct inhibition of the APC/C complex; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Cell cycle",677.8,636.1,716.2,610.4,655.3,485.9,1.1589974880109615,0.21287743947807242,0.17090052319325516,0.7672566077321837,0.42748525804911086,0.3690788574464887,2922]
["Q9UK23","N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [OS=Homo sapiens]",6,3,4,3,515,56,6.6,12.23,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport","other membranes;ER/Golgi","other molecular function","NAGPA","ENSG00000103174","Lysosome","","",321.4,297.4,296.2,318.8,369.4,440.7,0.8105235184693064,-0.30307404673027033,0.12095944595755533,0.9173602110800341,0.3697585071115734,0.43208182531183587,2391]
["Q9UK45","U6 snRNA-associated Sm-like protein LSm7 [OS=Homo sapiens]",54,5,11,5,103,11.6,5.27,20.11,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","LSM7","ENSG00000130332","RNA degradation; Spliceosome","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease","mRNA processing",1156,966,1283.2,1203.1,1268.4,913.7,1.0059080704241996,0.008498463788300409,0.9649862075821343,0.015478893924371073,0.9789152243189201,0.009254917190406227,7205]
["Q9UK97","F-box only protein 9 [OS=Homo sapiens]",9,3,3,3,447,52.3,6.15,9.57,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;other cell component","other molecular function","FBXO9","ENSG00000112146","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",262.1,295.5,255.9,282.5,265.3,548.2,0.7422445255474454,-0.4300335472879987,0.36572486038319724,0.436845517211108,0.5898241404547195,0.22927745651849457,4532]
["Q9UKG9-1","peroxisomal carnitine O-octanoyltransferase [OS=Homo sapiens]",8,3,3,3,612,70.1,7.08,9.46,"other metabolic processes;transport","cytosol;other cytoplasmic organelle;other cell component","other molecular function","CROT","ENSG00000005469","Peroxisome","Peroxisomal protein import; Beta-oxidation of pristanoyl-CoA","",116,129.7,119,123.8,123.7,96.6,1.059866317930834,0.08388230759913119,0.5284455587521618,0.2769997477158326,0.6867725086983554,0.16318709784362717,5624]
["Q9UKK3","Poly [ADP-ribose] polymerase 4 [OS=Homo sapiens]",19,24,55,24,1724,192.5,5.66,167.84,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","PARP4","ENSG00000102699","Base excision repair; Apoptosis","Maturation of nucleoprotein; Nicotinamide salvaging; Maturation of nucleoprotein","NAD+ biosynthetic pathways; 16p11.2 proximal deletion syndrome",4066,4164.5,4181.2,4340.3,4259.5,5710.1,0.8673505754757197,-0.20531285891210535,0.2511555849705871,0.6000571599494285,0.5093496588651557,0.2929839803724809,3604]
["Q9UKM9-1","RNA-binding protein Raly [OS=Homo sapiens]",74,19,91,1,306,32.4,9.17,296.76,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","RALY","ENSG00000125970","","","",13218.2,13401.5,13643,17710.5,16283.3,9766.3,0.9200778791638957,-0.12017211292610809,0.6587913527141684,0.18125211000800137,0.780532662828312,0.10760891836800777,6169]
["Q9UKQ2-1","Disintegrin and metalloproteinase domain-containing protein 28 [OS=Homo sapiens]",9,8,14,8,775,87.1,6.95,29.09,"protein metabolism;other biological processes","non-structural extracellular;plasma membrane;other membranes;mitochondrion","other molecular function","ADAM28","ENSG00000042980","","","",1385.8,1338.6,1390.2,1444.9,1472.7,1416.4,0.9493770189201659,-0.07494696727209957,0.034309839602240995,1.4645813122564024,0.2050454764127387,0.6881498074087149,1223]
["Q9UKV5","E3 ubiquitin-protein ligase AMFR [OS=Homo sapiens]",20,6,8,6,643,72.9,6.39,27.33,"cell-cell signaling;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","AMFR","ENSG00000159461","Protein processing in endoplasmic reticulum","ER Quality Control Compartment (ERQC); N-glycan trimming in the ER and Calnexin/Calreticulin cycle","Sterol regulatory element-binding proteins (SREBP) signaling",475,427.6,444,377.8,432.2,465,1.056156862745098,0.07882412285730811,0.4564414169573914,0.34061495509527584,0.6389830140857256,0.19451068642201852,5221]
["Q9UL15-1","BAG family molecular chaperone regulator 5 [OS=Homo sapiens]",25,8,17,8,447,51.2,6.05,44.99,"cell organization and biogenesis;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","BAG5","ENSG00000166170","","Regulation of HSF1-mediated heat shock response","",1013.7,1017.9,977.4,932.6,886.5,876.3,1.1163463678860281,0.1587847204486581,0.008361749364390974,2.0777028541610267,0.10972356571693649,0.9597000874507828,557]
["Q9UL26","Ras-related protein Rab-22A [OS=Homo sapiens]",26,4,7,4,194,21.8,8.15,16.74,"cell organization and biogenesis;transport","plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","RAB22A","ENSG00000124209","Endocytosis","RAB geranylgeranylation","",1122.6,947.3,1199.8,716.9,816.9,261.7,1.821052631578947,0.8647726193057766,0.057868330680532445,1.2375590454866316,0.26173244365347254,0.5821424400412261,1616]
["Q9ULC3","Ras-related protein Rab-23 [OS=Homo sapiens]",27,6,13,6,237,26.6,6.6,31.71,"cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","other molecular function","RAB23","ENSG00000112210","","RAB geranylgeranylation","Genes related to primary cilium development (based on CRISPR); Ciliopathies",1439.2,1327.9,1508.4,1206.6,1309.9,1080.4,1.1886624593399873,0.2493390957638397,0.05570532839033847,1.2541032612025214,0.25687712631229265,0.5902745658723186,1585]
["Q9ULH1-1","Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 [OS=Homo sapiens]",14,14,26,14,1129,125.4,7.31,81.99,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","ASAP1","ENSG00000153317","Endocytosis; Fc gamma R-mediated phagocytosis","VxPx cargo-targeting to cilium","EGF/EGFR signaling pathway; CCL18 signaling pathway",1977.3,1977.7,1903.9,1860.9,1884.6,1952.6,1.0282199329601094,0.040148885401574255,0.2193731966955055,0.6588164361885511,0.47977220067248644,0.3189649198619507,3342]
["Q9ULJ3","Zinc finger and BTB domain-containing protein 21 [OS=Homo sapiens]",2,3,4,3,1066,118.8,8.29,9.48,"other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","ZBTB21","ENSG00000173276","","","",542.9,451.7,475.6,592.5,636.5,524.7,0.8383417916405312,-0.25438954479020703,0.09004306578711349,1.0455497265573557,0.3237209876232231,0.48982914331142136,2033]
["Q9ULN7-5","Isoform 2 of Paraneoplastic antigen-like protein 8B [OS=Homo sapiens]",2,1,1,1,635,68.6,5.45,0,"","","","PNMA8B","ENSG00000204851","","","",38.4,39.9,30.3,38.5,34.3,36.4,0.9945054945054944,-0.00794875311549104,0.9534347157068843,0.020709038935671862,0.9704295135916471,0.013036003778868691,7181]
["Q9ULQ1-1","Two pore calcium channel protein 1 [OS=Homo sapiens]",3,2,2,2,816,94.1,8.27,6.27,"transport;signal transduction;other biological processes","other membranes;other cytoplasmic organelle","transporter activity;other molecular function","TPCN1","ENSG00000186815; ENSGGOG00000010443","Calcium signaling pathway","Stimuli-sensing channels","",120.1,87.7,103.1,95.7,92.7,85.3,1.135915235659481,0.18385518197610753,0.27670102693239307,0.557989229040313,0.5303980608048416,0.2753980724300106,3813]
["Q9ULU8-3","Isoform 3 of Calcium-dependent secretion activator 1 [OS=Homo sapiens]",4,3,5,1,1314,148.7,5.81,6.79,"","","","CADPS","","","","",38.8,44.1,38.9,40.1,37.4,55.4,0.9164785553047403,-0.12582697136984222,0.562787850354098,0.2496552868256494,0.7117868832389864,0.1476500194080594,5779]
["Q9ULZ3","apoptosis-associated speck-like protein containing a CARD [OS=Homo sapiens]",47,9,36,9,195,21.6,6.34,109.68,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function","PYCARD","ENSG00000103490","Necroptosis; NOD-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Legionellosis; Yersinia infection; Influenza A; Lipid and atherosclerosis","Neutrophil degranulation; The AIM2 inflammasome; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; CLEC7A/inflammasome pathway","Nucleotide-binding oligomerization domain (NOD) pathway; Nanomaterial-induced inflammasome activation; TYROBP causal network in microglia; Acute viral myocarditis; Cytosolic DNA-sensing pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Prostaglandin signaling",3481.4,3616.2,3679.6,3538.5,3974.9,3412.1,0.9864262505148506,-0.019716902016360723,0.7974435548196093,0.09830004770392281,0.8724015779339207,0.059283557573650475,6681]
["Q9UM13","Anaphase-promoting complex subunit 10 [OS=Homo sapiens]",11,2,3,2,185,21.2,9.06,7.44,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus","","ANAPC10","ENSG00000164162","Cell cycle; Oocyte meiosis; Ubiquitin mediated proteolysis; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection","Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; Senescence-Associated Secretory Phenotype (SASP); APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects","Cell cycle",254.7,297.5,313.8,285.7,268.4,187.7,1.1674305742787814,0.22333675711107764,0.30195129646452046,0.5200631013556196,0.5520165147221561,0.25804792925374487,3998]
["Q9UMS4","Pre-mRNA-processing factor 19 [OS=Homo sapiens]",51,15,72,15,504,55.1,6.61,239.65,"cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","PRPF19","ENSG00000110107","Spliceosome; Ubiquitin mediated proteolysis","mRNA Splicing - Major Pathway; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of TC-NER Pre-Incision Complex","",8567.8,8825.9,8919.9,9516.5,9443,6134,1.0486221531472293,0.06849492960323049,0.7349788649338016,0.13372514931661714,0.8295183020075906,0.08117402751398024,6476]
["Q9UNA1-1","Rho GTPase-activating protein 26 [OS=Homo sapiens]",6,4,5,4,814,92.2,6.64,11.44,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","ARHGAP26","ENSG00000145819","","RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOB GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOD GTPase cycle; RHOQ GTPase cycle","",521.7,555,568.2,482.9,418.3,989.1,0.8701793366132361,-0.2006153360180637,0.6747320007690204,0.17086869190809664,0.78994332750613,0.10240406495541306,6243]
["Q9UNF1","Melanoma-associated antigen D2 [OS=Homo sapiens]",41,19,58,18,606,64.9,9.32,192.7,"transport;other biological processes","non-structural extracellular;cytosol;nucleus;other cell component","","MAGED2","ENSG00000102316","","Platelet degranulation","",6453.3,6852.3,6610.2,8736.3,8331.5,8860,0.7681253326545252,-0.38058636460931455,5.2938718001105118E-4,3.2762265800688093,0.03251504956891406,1.4879155795773669,119]
["Q9UNM6","26S proteasome non-ATPase regulatory subunit 13 [OS=Homo sapiens]",61,21,115,21,376,42.9,5.81,329.62,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","PSMD13","ENSG00000185627","Proteasome; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Prion disease; Pathways of neurodegeneration; Epstein-Barr virus infection","Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; ROS sensing by NFE2L2; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling","Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease",18136,18452.7,18121.1,16496.8,15674.4,9014.6,1.3283656017365209,0.40965226959232054,0.13008984757105085,0.8857565951825684,0.3803306783587243,0.4198386419706331,2500]
["Q9UNS1","Protein timeless homolog [OS=Homo sapiens]",7,6,12,6,1208,138.6,5.4,27.19,"cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity","TIMELESS","ENSG00000111602","","Processing of DNA double-strand break ends","",355.7,359.5,330.6,524.2,513.7,737.1,0.5891830985915495,-0.7632120493199274,0.02953993591295156,1.529590451227241,0.19260249026562262,0.7153381019382411,1121]
["Q9UNZ2","NSFL1 cofactor p47 [OS=Homo sapiens]",61,22,122,1,370,40.5,5.1,384.24,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component","other molecular function","NSFL1C","ENSG00000088833","Protein processing in endoplasmic reticulum","RHOH GTPase cycle","",14553.7,14486,14023.3,14706.7,15005.6,17377.1,0.9144945571614843,-0.12895351144098405,0.1940554748529411,0.712074100077378,0.4517042884395371,0.34514578626662007,3140]
["Q9UPN9-2","Isoform Beta of E3 ubiquitin-protein ligase TRIM33 [OS=Homo sapiens]",7,7,8,1,1110,120.5,6.67,20.82,"","","","TRIM33","","","","",73.5,66.9,69,81.2,86.9,63.8,0.9029754204398446,-0.14724137771519547,0.3572908372215078,0.44697812120355807,0.5875002765471318,0.23099192462581752,4445]
["Q9UPQ3-1","Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 [OS=Homo sapiens]",4,3,8,2,857,94.4,7.94,10.84,"transport","nucleus;other cell component","enzyme regulator activity;other molecular function","AGAP1","ENSG00000157985","Endocytosis","","",214.6,242.8,217.8,184.4,181.9,233.8,1.1251458090318283,0.17011197418566573,0.26028954448573405,0.5845432766212622,0.5178160807420332,0.2858244667070787,3674]
["Q9UPT6","C-Jun-amino-terminal kinase-interacting protein 3 [OS=Homo sapiens]",4,7,12,4,1336,147.4,5.4,32.57,"cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","cytoskeletal activity;other molecular function","MAPK8IP3","ENSG00000138834","MAPK signaling pathway","","MAPK signaling pathway",936.7,915.5,858.6,244,246.7,379.3,3.115862068965517,1.6396313704907877,2.6079636149738394E-4,3.5836984719609437,0.0250810606076892,1.6006541023577618,76]
["Q9UPY8","Microtubule-associated protein RP/EB family member 3 [OS=Homo sapiens]",19,5,11,1,281,32,5.54,26.85,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MAPRE3","ENSG00000084764","","","",30.2,20.3,23.2,22.4,24.6,13,1.2283333333333333,0.29670211859918877,0.3783155930915194,0.42214575795642423,0.5951589905092372,0.22536700153666786,4646]
["Q9UPY8-2","Isoform 2 of Microtubule-associated protein RP/EB family member 3 [OS=Homo sapiens]",19,5,11,1,266,30.4,5.3,28.17,"","","","MAPRE3","","","","",202.3,208.5,201.5,194.9,218.3,448.5,0.7105721248694441,-0.49294700078818615,0.36245594777081036,0.4407447692381397,0.5884474727358625,0.2302922980186679,4502]
["Q9UQ90","Paraplegin [OS=Homo sapiens]",11,7,10,7,795,88.2,8.69,29.27,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes","other membranes;mitochondrion;other cell component","other molecular function","SPG7","ENSG00000197912","","Processing of SMDT1","",780.5,821.5,736.4,704.2,703.1,870,1.0268300180037764,0.03819737690459262,0.7538966401179062,0.12268819219844564,0.8421565860647681,0.07460715061283534,6543]
["Q9UQL6-1","histone deacetylase 5 [OS=Homo sapiens]",5,4,6,4,1122,121.9,6.24,18.79,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;ER/Golgi;nucleus;other cell component","nucleic acid binding activity;other molecular function","HDAC5","ENSG00000108840","Apelin signaling pathway; Neutrophil extracellular trap formation; Alcoholism; Viral carcinogenesis; MicroRNAs in cancer","Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Regulation of PTEN gene transcription","MicroRNAs in cardiomyocyte hypertrophy; Cell differentiation - expanded index; Cell differentiation - index; Neural crest differentiation; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; VEGFA-VEGFR2 signaling pathway; Ethanol effects on histone modifications; Rett syndrome causing genes",299.8,339.1,264.9,279.3,268.1,372,0.9830324124428976,-0.024689109145800275,0.9010905561263517,0.04523156190689331,0.9353885633755865,0.02900794434117535,7041]
["Q9Y222-1","Cyclin-D-binding Myb-like transcription factor 1 [OS=Homo sapiens]",3,2,2,2,760,84.4,4.61,4.62,"cell cycle OR cell proliferation;other biological processes","cytosol;nucleus","nucleic acid binding activity;other molecular function","DMTF1","ENSG00000135164","","","",88.4,105.9,87.7,97.5,83.5,79.9,1.0808738980452282,0.11219821846870395,0.4298184639667337,0.36671493219815887,0.622704291998584,0.20571814088711524,5045]
["Q9Y248","Dna replication complex gins protein psf2 [OS=Homo sapiens]",16,3,4,3,185,21.4,5.44,9.5,"DNA metabolism;other metabolic processes;stress response","nucleus","","GINS2","ENSG00000131153","","Unwinding of DNA","",317,326.3,346,346.6,381.8,455,0.8359810714889301,-0.2584578181053766,0.12189781445782151,0.9140040809067781,0.37061194919809376,0.431080582353507,2404]
["Q9Y259-1","Choline/ethanolamine kinase [OS=Homo sapiens]",8,3,3,3,395,45.2,5.49,5.95,"other metabolic processes","cytosol","kinase activity;other molecular function","CHKB","ENSG00000100288","Glycerophospholipid metabolism; Metabolic pathways; Choline metabolism in cancer","Synthesis of PC; Synthesis of PE","Fatty acid beta-oxidation; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids",192.8,221.4,190.2,180.1,175.5,597.2,0.6343408900083963,-0.6566697526992848,0.45392992949086886,0.3430111814690743,0.6369310529177885,0.1959075770177985,5209]
["Q9Y281-1","Cofilin-2 [OS=Homo sapiens]",33,5,42,1,166,18.7,7.88,107.36,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component","cytoskeletal activity","CFL2; CFL2b; LOC101358143; LOC111160529","ENSAMEG00000015508; ENSANAG00000001737; ENSBIXG00000015466; ENSBIXG00005004635; ENSBTAG00000015053; ENSCAFG00000032562; ENSCANG00000033619; ENSCCAG00000037328; ENSCHIG00000015758; ENSCJAG00000041665; ENSCPOG00000033162; ENSECAG00000000511; ENSFCAG00000008480; ENSG00000165410; ENSGGOG00000038032; ENSHGLG00000001467; ENSLCNG00005006126; ENSMFAG00000001352; ENSMLEG00000005793; ENSMMNG00015019505; ENSMMUG00000039560; ENSMNEG00000039241; ENSMPUG00000016306; ENSNLEG00000003417; ENSPANG00000021779; ENSPCOG00000013026; ENSPCTG00005008413; ENSPPAG00000007558; ENSPPYG00000005737; ENSPTRG00000006254; ENSRROG00000036826; ENSSBOG00000014011; ENSSSCG00000001959; ENSSSCG00015060726; ENSSSCG00025071059; ENSSSCG00030060165; ENSSSCG00035044355; ENSSSCG00040010975; ENSSSCG00045008975; ENSSSCG00050005802; ENSSSCG00055017925; ENSSSCG00060075576; ENSSSCG00065063654; ENSSSCG00070007061; ENSSSUG00005010833; ENSVVUG00000019333","Axon guidance; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Pertussis; Human immunodeficiency virus 1 infection","","Actin cytoskeleton regulation; G13 signaling pathway; G13 signaling pathway; Leptin signaling pathway; Microtubule cytoskeleton regulation; Microtubule cytoskeleton regulation; Leptin signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; G13 signaling pathway",58.8,59.9,73,63.6,55.9,53,1.111304347826087,0.1522539751152568,0.31309435919441425,0.5043247566973842,0.5600603698854562,0.25176515710984004,4086]
["Q9Y2C4","Nuclease EXOG, mitochondrial [OS=Homo sapiens]",7,3,6,3,368,41.1,8.27,11.83,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes","other membranes;mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","EXOG","ENSG00000157036","","","",742.4,764.9,736.4,743.2,738,671.8,1.0421272642823967,0.05953146987921698,0.2858405686726077,0.5438761327868302,0.536657774576956,0.2703025746210192,3893]
["Q9Y2D4","Exocyst complex component 6B [OS=Homo sapiens]",9,7,9,6,811,94.1,6.46,28.88,"cell organization and biogenesis;transport","other membranes;other cell component","","EXOC6B","ENSG00000144036","","","Ciliary landscape",609.2,635,624.2,602.3,531.1,718.3,1.0090187395366421,0.012952968483446587,0.9243399805165443,0.0341682619994185,0.9510136426795359,0.021813252885990092,7104]
["Q9Y2H0-1","Isoform 2 of Disks large-associated protein 4 [OS=Homo sapiens]",3,2,2,2,989,107.5,7.3,6.2,"","","","DLGAP4","","","","",126.6,111.4,135.2,168.6,167.9,195.8,0.7011083975201954,-0.5122905800737273,0.010013930673671043,1.9993954195424957,0.1197902116102482,0.9215786679010769,611]
["Q9Y2H6","Fibronectin type-III domain-containing protein 3a [OS=Homo sapiens]",11,9,18,9,1198,131.8,6.71,49.03,"cell adhesion;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cell component","","FNDC3A","ENSG00000102531","","","",1519.2,1515.3,1580.4,1463.7,1450.1,825.3,{"$f":"AVERAGE(S7042:U7042)/AVERAGE(V7042:X7042)","v":1.2342274878981572},{"$f":"LOG(Y7042,2)","v":0.30360833080403754},{"$f":"TTEST(V7042:X7042,S7042:U7042,2,2)","v":0.239842649942774},0.620073586092,{"$f":"AA7042*7309/AE7042","v":0.49914861287919565},0.301770131442092,3512]
["Q9Y2K7","Lysine-specific demethylase 2A [OS=Homo sapiens]",18,21,32,21,1162,132.7,7.58,78.47,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus","nucleic acid binding activity;other molecular function","KDM2A","ENSG00000173120","","HDMs demethylate histones","",2947.8,3105.4,3155.7,3333.4,3320.5,2496.9,1.0063491716571231,0.009130962017804625,0.9488523139988359,0.02280137893902842,0.9671121967671861,0.014523139556773314,7171]
["Q9Y2R0","Cytochrome c oxidase assembly factor 3 homolog, mitochondrial [OS=Homo sapiens]",27,3,7,3,106,11.7,9.6,19.06,"cell organization and biogenesis;other biological processes","other membranes;mitochondrion","","COA3","ENSG00000183978","Thermogenesis","","Mitochondrial complex IV assembly",430.8,453.5,877.2,604.4,982.6,283.6,0.941676467443601,-0.0866966178389601,0.8908412031966416,0.05019970418053681,0.9289710877677635,0.03199780228010814,7009]
["Q9Y2R9","28S ribosomal protein S7, mitochondrial [OS=Homo sapiens]",15,3,10,3,242,28.1,9.99,35.8,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPS7","ENSG00000125445","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",1066.3,1059.9,1739.3,1572,1982.6,1426.1,0.7760957295159315,-0.3656934785833645,0.2554169836568088,0.5927502282033673,0.5124465367959417,0.2903514375613103,3643]
["Q9Y2S0-1","DNA-directed RNA polymerases I and III subunit RPAC2 [OS=Homo sapiens]",24,3,7,3,133,15.2,5.8,19.33,"RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","POLR1D","ENSG00000186184; ENSGGOG00000004235; ENSNLEG00000000358; ENSPTRG00000005734","RNA polymerase; Cytosolic DNA-sensing pathway","","Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway",531,487.9,576.5,604.5,638.3,889.7,0.7481359906213365,-0.418627558514191,0.12812703719719915,0.8923592163399288,0.37700503819417414,0.4236528459604984,2484]
["Q9Y2S7","Polymerase delta-interacting protein 2 [OS=Homo sapiens]",41,12,33,12,368,42,8.63,108.07,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component","nucleic acid binding activity","POLDIP2","ENSG00000004142","","","",3042.8,3423.1,3417.7,3231,2999.9,5148.5,0.8685519447422535,-0.2033159613448366,0.5113490556785478,0.2912825417374761,0.6763391690109494,0.16983546043399567,5526]
["Q9Y2T2","ap-3 complex subunit mu-1 [OS=Homo sapiens]",30,8,16,7,418,46.9,6.93,58.53,"transport","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","AP3M1","ENSG00000185009","Lysosome","Association of TriC/CCT with target proteins during biosynthesis","",1508,1525.3,1631.4,1369.3,1354.9,1120.2,1.2133752991364066,0.2790258476223074,0.03781557455197411,1.4223292967525658,0.21376182088196347,0.670069859748987,1293]
["Q9Y2U5","Mitogen-activated protein kinase kinase kinase 2 [OS=Homo sapiens]",8,4,5,2,619,69.7,8,15.49,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol;nucleus","kinase activity;other molecular function","MAP3K2","ENSG00000169967","MAPK signaling pathway; Gap junction; GnRH signaling pathway","","IL-1 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; MAPK cascade; EGF/EGFR signaling pathway; Insulin signaling; Malignant pleural mesothelioma",195,209.1,180.3,230.2,191.5,185.3,0.9627677100494235,-0.0547403383395459,0.6684274391334369,0.17494573050269577,0.7867207975243624,0.10417936879530298,6210]
["Q9Y2U8","inner nuclear membrane protein Man1 [OS=Homo sapiens]",29,20,56,20,911,99.9,7.55,184,"cell organization and biogenesis;other biological processes","other membranes;nucleus","nucleic acid binding activity","LEMD3","ENSG00000174106","","RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOG GTPase cycle; RND2 GTPase cycle; RHOD GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; Initiation of Nuclear Envelope (NE) Reformation; Depolymerisation of the Nuclear Lamina","Envelope proteins and their potential roles in EDMD physiopathology",5420.6,5389.2,5164.5,5421.7,5449.2,6775,0.9052697793821793,-0.14358030117006834,0.28682351277626605,0.5423852496206074,0.5375366807389047,0.2695918947631337,3900]
["Q9Y2V2","Calcium-regulated heat-stable protein 1 [OS=Homo sapiens]",29,4,22,4,147,15.9,8.21,91.27,"signal transduction;other biological processes","cytosol;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","CARHSP1","ENSG00000153048","","","",2976.9,2898.9,2817.3,2641.4,2660.6,2835.7,1.0682502426975682,0.09524964478737305,0.07425559229831544,1.1292708334202772,0.2980418034642435,0.5257228173312244,1821]
["Q9Y2V7-1","Conserved oligomeric Golgi complex subunit 6 [OS=Homo sapiens]",7,5,6,5,657,73.2,5.76,14.61,"other metabolic processes;transport","other membranes;ER/Golgi","","COG6","ENSG00000133103","","Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network; COPI-mediated anterograde transport","",334.9,386.9,349.6,313.5,311.1,765.2,0.7709022880990071,-0.3753800848229299,0.5228641406046318,0.28161114220468675,0.6832851785587796,0.16539799964896199,5593]
["Q9Y2W1","Thyroid hormone receptor-associated protein 3 [OS=Homo sapiens]",38,42,191,41,955,108.6,10.15,496.99,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","THRAP3","ENSG00000054118","","PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation","Interactome of polycomb repressive complex 2 (PRC2)",28854.9,27837.6,26875,26341.1,28273.6,22863.1,1.0785992890866805,0.10915898806971572,0.2942356955576995,0.5313046414543278,0.5434846345289932,0.26481272983638243,3957]
["Q9Y2W2","WW domain-binding protein 11 [OS=Homo sapiens]",17,12,38,12,641,70,8.38,88.86,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","WBP11","ENSG00000084463","Spliceosome","mRNA Splicing - Major Pathway","",4760.1,4955.3,4555.9,6116.1,6297.7,6088.9,0.7713090521923829,-0.3746190522217534,0.000442691368380785,3.3538989458348873,0.030524822749954317,1.5153468492156845,106]
["Q9Y2W6","tudor and KH domain-containing protein [OS=Homo sapiens]",27,12,19,12,561,62,5.02,53.9,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","mitochondrion;other cell component","nucleic acid binding activity","TDRKH","ENSG00000182134","","PIWI-interacting RNA (piRNA) biogenesis","",2028.9,2060.8,2039.9,2171.1,2042.3,2490.2,0.9143743660122919,-0.12914313593834528,0.22497060565262117,0.6478742224966842,0.4851903678710558,0.3140878294500895,3389]
["Q9Y2X0-1","Mediator of RNA polymerase II transcription subunit 16 [OS=Homo sapiens]",7,7,8,7,877,96.7,7.37,15.28,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","MED16","ENSG00000175221","Thyroid hormone signaling pathway","Transcriptional regulation of white adipocyte differentiation; Generic Transcription Pathway; PPARA activates gene expression","",779.3,757.3,771.2,807.2,817.6,1086.3,0.8512411936114492,-0.2323601268713861,0.2160132985961004,0.6655195112142599,0.47670326070015034,0.32175187744312944,3312]
["Q9Y2X3","Nucleolar protein 58 [OS=Homo sapiens]",52,27,199,27,529,59.5,8.92,613.24,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","NOP58","ENSG00000055044","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; SUMOylation of RNA binding proteins; rRNA modification in the nucleus and cytosol","",27733.6,26406,26280.3,24997,25124,15352.5,1.2282816712104896,0.2966414394221085,0.2022209360793486,0.6941738835964275,0.4608770881833361,0.336414881640895,3207]
["Q9Y2X7-1","ARF GTPase-activating protein GIT1 [OS=Homo sapiens]",27,17,25,15,761,84.3,6.8,70.26,"developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","GIT1","ENSG00000108262","Endocytosis; Regulation of actin cytoskeleton; Epithelial cell signaling in Helicobacter pylori infection","RHOJ GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOU GTPase cycle; CDC42 GTPase cycle; RHOQ GTPase cycle; RHOV GTPase cycle; Ephrin signaling; Activation of RAC1 downstream of NMDARs","CAMKK2 pathway; Regulation of actin cytoskeleton",2227,2233,2158,2088.4,2070.2,1963.3,1.0810369329783236,0.11241581272517288,0.022614341248260377,1.6456160586548447,0.17092887299228035,0.7671845708538735,967]
["Q9Y2X9","Zinc finger protein 281 [OS=Homo sapiens]",1,1,2,1,895,96.9,8.48,4.27,"developmental processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","ZNF281","ENSG00000162702","","","Mesodermal commitment pathway",78,77.5,76.8,95.8,122.9,102.6,0.7230003112356055,-0.4679318266626042,0.021942819344006513,1.6587075724367633,0.16917728542757762,0.7716579478908565,948]
["Q9Y2Y0","ADP-ribosylation factor-like protein 2-binding protein [OS=Homo sapiens]",34,5,13,5,163,18.8,4.35,30.82,"signal transduction;other biological processes","cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","enzyme regulator activity;other molecular function","ARL2BP","ENSG00000102931","","Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane","Ciliopathies",1223.3,1298.3,1113.8,1387.7,1358.9,869.9,1.0052260472832848,0.007519959737053283,0.9732122576603485,0.011792429744583534,0.983710191016386,0.007132829394487961,7231]
["Q9Y2Y9","Krueppel-like factor 13 [OS=Homo sapiens]",9,2,2,1,288,31.2,9.54,6.01,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KLF13","ENSG00000169926; ENSG00000275746","","","15q13.3 copy number variation syndrome",104.2,112.5,92.1,195,197.1,225.9,0.4996763754045307,-1.0009340855236566,8.8516086001458989E-4,3.0529777979254105,0.04068956431350086,1.3905169603618888,159]
["Q9Y2Z0-1","Protein SGT1 homolog [OS=Homo sapiens]",46,14,43,14,365,41,5.16,124.5,"cell cycle OR cell proliferation;other biological processes","cytosol;nucleus;other cell component","other molecular function","SUGT1","ENSG00000165416; ENSPTRG00000005906","NOD-like receptor signaling pathway","The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection","Nucleotide-binding oligomerization domain (NOD) pathway",5424.7,5633.7,5831.9,5475.8,5403.5,4255.8,1.1159688406419515,0.1582967457343867,0.22887800329476132,0.6403959439211162,0.489143077801582,0.31056408809327823,3420]
["Q9Y2Z2-6","Isoform 7 of Protein MTO1 homolog, mitochondrial [OS=Homo sapiens]",10,6,7,6,732,81.5,8.16,15.6,"","","","MTO1","","","","",246.9,269.6,250.3,304.9,309.6,282.4,0.8549448099007694,-0.22609680360506706,0.016790616073138812,1.7749333686471784,0.15021127647315982,0.8232974632956209,817]
["Q9Y2Z4","Tyrosine--tRNA ligase, mitochondrial [OS=Homo sapiens]",27,10,15,10,477,53.2,8.98,35.42,"protein metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;mitochondrion;nucleus","nucleic acid binding activity;other molecular function","YARS2","ENSG00000139131","Aminoacyl-tRNA biosynthesis","Mitochondrial tRNA aminoacylation","Orexin receptor pathway",1329.5,1352.4,1359.9,1303.9,1286.9,1083,1.1001687625891445,0.1377248458185542,0.16163160407245628,0.791473717000142,0.41951896099630076,0.3772484055862436,2816]
["Q9Y2Z9-1","Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial [OS=Homo sapiens]",6,3,4,3,468,50.8,7.3,4.76,"other metabolic processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","COQ6","ENSG00000119723","Ubiquinone and other terpenoid-quinone biosynthesis; Metabolic pathways; Biosynthesis of cofactors","Ubiquinol biosynthesis","Nephrotic syndrome",338.1,438.8,409,336.2,279.4,198.9,1.455985267034991,0.5419957571278902,0.06772234172336598,1.1692680331391099,0.2828471975177611,0.5484481199414315,1750]
["Q9Y303","N-acetylglucosamine-6-phosphate deacetylase [OS=Homo sapiens]",22,7,18,1,409,43.7,6.7,58.49,"other metabolic processes","cytosol","other molecular function","AMDHD2","ENSG00000162066","Amino sugar and nucleotide sugar metabolism; Metabolic pathways","Synthesis of UDP-N-acetyl-glucosamine","",125.2,113.4,108.1,116.2,133.1,132.4,0.9083049515326173,-0.13875135001272473,0.1940473506846073,0.7120922822767632,0.4518292724287336,0.3450256360928327,3139]
["Q9Y303-3","Isoform 3 of N-acetylglucosamine-6-phosphate deacetylase [OS=Homo sapiens]",19,8,18,2,594,63.6,7.53,56.95,"","","","AMDHD2","","","","",1589,1587.6,1460.3,1541.1,1527.1,2130.1,0.8920031548775562,-0.1648792821429528,0.40928019346970695,0.3879792719072496,0.6122449721797151,0.2130747726606946,4886]
["Q9Y305-1","Acyl-coenzyme A thioesterase 9, mitochondrial [OS=Homo sapiens]",34,14,39,14,439,49.9,8.6,116.05,"other metabolic processes","mitochondrion","other molecular function","ACOT9","ENSG00000123130","","Mitochondrial Fatty Acid Beta-Oxidation","VEGFA-VEGFR2 signaling pathway",2971.7,2986.3,2930.1,2837.9,2676.8,3382.1,0.9990221203129215,-1.4114724127664714E-3,0.9898388654000654,0.004435497890584129,0.9943282390336831,0.002470226398057123,7276]
["Q9Y312","Protein AAR2 homolog [OS=Homo sapiens]",24,6,14,6,384,43.4,5.96,36.75,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","","AAR2","ENSG00000131043","","","Ciliary landscape",1092.7,1100.1,1108.1,1128.1,1185.6,1205,0.9381021399948846,-0.09218308382928833,0.036661321913724336,1.4357918795405884,0.2104930101079428,0.6767623213102707,1273]
["Q9Y314","nitric oxide synthase-interacting protein [OS=Homo sapiens]",45,8,17,8,301,33.2,8.82,55.24,"protein metabolism;other metabolic processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","other molecular function","NOSIP","ENSG00000142546","","NOSIP mediated eNOS trafficking","",1204.5,1160.9,1341.5,1297,1334,865.9,1.0600531899682577,0.08413665627733867,0.6839596490838366,0.164969519182147,0.7961556099942286,0.09900204035652294,6279]
["Q9Y315","deoxyribose-phosphate aldolase [OS=Homo sapiens]",31,10,21,10,318,35.2,8.94,65.5,"other metabolic processes","non-structural extracellular;cytosol;nucleus;other cell component","other molecular function","DERA","ENSG00000023697","Pentose phosphate pathway; Metabolic pathways","Neutrophil degranulation; Pentose phosphate pathway","",2835.4,2945.5,2768.1,2670.1,2677.3,2588.8,1.0772157959728836,0.10730729035944536,0.025739929415015253,1.5893926483683614,0.18212308237594044,0.739635008004009,1033]
["Q9Y316-1","Protein MEMO1 [OS=Homo sapiens]",39,9,21,9,297,33.7,7.14,62.18,"other biological processes","","other molecular function","LOC111154137; LOC114499315; MEMO1","ENSANAG00000021250; ENSCANG00000020056; ENSCATG00000030724; ENSCCAG00000037443; ENSCHIG00000006439; ENSCJAG00000003208; ENSDLEG00000015222; ENSECAG00000019946; ENSFCAG00000001385; ENSG00000162959; ENSHGLG00000018935; ENSMMUG00000003908; ENSMNEG00000040106; ENSMODG00000047380; ENSPANG00000022798; ENSPCOG00000018130; ENSPCTG00005009736; ENSPTRG00000050445; ENSRFEG00010015180; ENSSSCG00000008515; ENSSSCG00070008027; ENSVURG00010020209; ENSVVUG00000007616","","ERBB2 Regulates Cell Motility; ERBB2 Regulates Cell Motility","",2209.3,2166.1,2208.3,2141.8,2131.2,1889.4,1.0683662209528755,0.0954062674258238,0.16846370595167232,0.7734936497049206,0.4253199401729786,0.3712842558844026,2895]
["Q9Y320","Thioredoxin-related transmembrane protein 2 [OS=Homo sapiens]",40,11,38,11,296,34,8.69,125.59,"developmental processes","other membranes;mitochondrion;ER/Golgi;other cell component","other molecular function","TMX2","ENSG00000213593","","","",5339.6,5051.9,5356.7,4534.8,4799.9,4497.3,1.1385338345864662,0.1871771656640775,0.009641092846093862,2.015873734756142,0.11803475311909553,0.9279901040015381,597]
["Q9Y333","U6 snRNA-associated Sm-like protein LSm2 [OS=Homo sapiens]",75,6,22,6,95,10.8,6.52,72.61,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LSM2","ENSG00000172850; ENSG00000204392; ENSG00000224979; ENSG00000225998; ENSG00000231502; ENSG00000236826","RNA degradation; Spliceosome","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease; mRNA Splicing - Minor Pathway","mRNA processing",2206.3,2472.8,2998.8,2644.8,2300,1727.3,1.1507471410800199,0.20257085832994948,0.3980541999548359,0.4000577893868953,0.6059941985981869,0.21753153347208806,4801]
["Q9Y365","START domain-containing protein 10 [OS=Homo sapiens]",12,2,4,2,291,33,7.12,6.11,"transport","other membranes;cytosol;cytoskeleton;other cell component","other molecular function","STARD10","ENSG00000214530","","Synthesis of PC","",13.4,12.8,17.6,17,12,3.9,1.331306990881459,0.41284328586593194,0.4260615308359848,0.3705276765478897,0.6213255644214312,0.20668077698602913,5012]
["Q9Y371","Endophilin-B1 [OS=Homo sapiens]",28,12,35,11,365,40.8,6.04,97.7,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","SH3GLB1","ENSG00000097033","Autophagy; Endocytosis","","Nanoparticle triggered autophagic cell death; Senescence and autophagy in cancer",3822.7,3666.3,3660.5,3687.5,3427,1953.7,1.2295163317968283,0.29809089853367426,0.2700261388595527,0.5685941935706151,0.524341405134025,0.28038584644186154,3764]
["Q9Y375","Complex I intermediate-associated protein 30, mitochondrial [OS=Homo sapiens]",36,11,26,11,327,37.7,7.64,91.39,"cell organization and biogenesis;other metabolic processes","other membranes;cytosol;mitochondrion","other molecular function","NDUFAF1","ENSG00000137806","Thermogenesis","Complex I biogenesis","Mitochondrial immune response to SARS-CoV-2",2713,2751.8,2588.5,2697.6,2847.7,3446.4,0.8956370875362836,-0.15901382473968156,0.252214672176419,0.5982296526562321,0.5105059648123641,0.29199917919908563,3611]
["Q9Y376","Calcium-binding protein 39 [OS=Homo sapiens]",45,16,38,16,341,39.8,6.89,98.08,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","non-structural extracellular;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;other molecular function","CAB39","ENSG00000135932","mTOR signaling pathway; AMPK signaling pathway","Neutrophil degranulation; Energy dependent regulation of mTOR by LKB1-AMPK","AMP-activated protein kinase (AMPK) signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias",6678.7,6697.1,6815.8,6320.1,6471.8,6590.3,1.041759965329013,0.059022900723911566,0.03901183838280349,1.4088035836360397,0.21634106732921904,0.6648610320100579,1318]
["Q9Y383","Putative RNA-binding protein Luc7-like 2 [OS=Homo sapiens]",40,20,182,14,392,46.5,10.01,519.86,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","nucleus","nucleic acid binding activity;other molecular function","LUC7L2","ENSG00000146963","","","",20174.6,20187.3,19451.3,20480.8,21202.6,18635.2,0.9916211583160088,-0.01213904021149706,0.8439285485170908,0.07369432150033829,0.9010040550849279,0.045273254418223614,6846]
["Q9Y385","ubiquitin-conjugating enzyme e2 j1 [OS=Homo sapiens]",33,9,26,9,318,35.2,6.74,93.82,"protein metabolism;other metabolic processes;stress response;other biological processes","other membranes;ER/Golgi;nucleus","other molecular function","UBE2J1","ENSG00000198833","Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum; Parkinson disease; Pathways of neurodegeneration","Antigen processing: Ubiquitination & Proteasome degradation","Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway",1695.3,1694.8,1686.2,2608.3,2758.8,3543.6,0.5696858832639411,-0.8117614380160587,0.011620589264775643,1.9347718488861536,0.12772163449059426,0.8937355323052852,665]
["Q9Y388","RNA-binding motif protein, X-linked 2 [OS=Homo sapiens]",15,5,9,5,322,37.3,9.83,24.14,"RNA metabolism OR transcription;other metabolic processes","nucleus","","RBMX2","ENSG00000134597","","","",1321.3,1234.7,1325.4,1429.7,1465.7,1287.6,0.9278986373416208,-0.10796087939613566,0.17962756413953615,0.7456270193659812,0.43734106139102924,0.35917974538925973,3002]
["Q9Y394","Dehydrogenase/reductase SDR family member 7 [OS=Homo sapiens]",40,9,16,9,339,38.3,8.32,51.28,"","","other molecular function","DHRS7","ENSG00000100612","","","",1690.3,1647.4,1684.4,1497.4,1495,1290.3,1.1726480958273988,0.229770134786389,0.02435976153962851,1.6133269673745636,0.17733615248321194,0.7512027182995913,1004]
["Q9Y399","28S ribosomal protein S2, mitochondrial [OS=Homo sapiens]",12,5,13,5,296,33.2,9.26,31.26,"cell organization and biogenesis;protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","other molecular function","MRPS2","ENSG00000122140","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",2068.5,1992.5,2147.8,1887.4,1788.1,1304.1,1.2468471363161697,0.31828460133687053,0.09195822306305149,1.0364094293271542,0.32595666943154383,0.48684012839067886,2062]
["Q9Y3A0-1","Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial [OS=Homo sapiens]",15,4,6,4,265,29.6,9.17,14.49,"other metabolic processes","other membranes;mitochondrion;other cell component","","COQ4","ENSG00000167113","","","",201,181.6,168.5,188.1,200.5,285.5,0.8175344904316867,-0.29064849806855775,0.2697572431226815,0.5690268854551321,0.5243765132935317,0.2803567684988202,3760]
["Q9Y3A3","MOB-like protein phocein [OS=Homo sapiens]",46,7,22,7,225,26,5.78,49.1,"","other membranes;ER/Golgi;other cell component","other molecular function","MOB4","ENSG00000115540","","","",910.6,984.4,1177,1157.1,1134.6,928.1,0.9540965277346419,-0.06779286111020584,0.6713217481481197,0.1730692831774711,0.7877172350641527,0.10362965216763913,6229]
["Q9Y3A4","Ribosomal RNA-processing protein 7 homolog A [OS=Homo sapiens]",21,5,9,5,280,32.3,9.58,22.92,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","","RRP7A","ENSG00000189306","Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",923,917.4,1009.4,2353.5,2293.2,1679.8,0.450454437682763,-1.150546906392069,0.0059497572179786,2.225500755455216,0.09453646849175128,1.0244006252528173,460]
["Q9Y3A5","Ribosome maturation protein SBDS [OS=Homo sapiens]",54,17,52,17,250,28.7,8.75,132.39,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;translation activity;nucleic acid binding activity","SBDS","ENSG00000126524","Ribosome biogenesis in eukaryotes","","",6411.9,6605.6,7651.8,7376.6,6836.8,6523.9,0.9967208845896041,-0.004738536898705581,0.962950209569684,0.016396167982596698,0.9776639924635117,0.009810379662665106,7199]
["Q9Y3A6-1","Transmembrane emp24 domain-containing protein 5 [OS=Homo sapiens]",36,7,15,7,229,26,4.84,29.15,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED5","ENSG00000117500","","WNT ligand biogenesis and trafficking","",2195.4,2100,2088.5,1839.6,1838.2,1107.8,1.3339811099966565,0.4157382372068298,0.09631230973289773,1.0163182018950314,0.3328353058334513,0.4777706117221197,2115]
["Q9Y3B2","Exosome complex component csl4 [OS=Homo sapiens]",28,4,6,4,195,21.4,8.24,17.07,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","nucleic acid binding activity","EXOSC1","ENSG00000171311","RNA degradation","Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum  stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease","",669.8,759.8,805,739.7,595.9,337.1,1.3359239552818798,0.4178378877070643,0.20636321096450488,0.6853677232230513,0.46509673417809627,0.33245671001205107,3243]
["Q9Y3B3-1","Transmembrane emp24 domain-containing protein 7 [OS=Homo sapiens]",33,6,21,6,224,25.2,6.89,52.45,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED7","ENSG00000134970; ENSPTRG00000017152","","COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic","Regulation of toll-like receptor signaling pathway",2463.8,3039.7,3293.7,2413.6,1963.2,2249.3,{"$f":"AVERAGE(S7106:U7106)/AVERAGE(V7106:X7106)","v":1.3276588038212522},{"$f":"LOG(Y7106,2)","v":0.4088844348772442},{"$f":"TTEST(V7106:X7106,S7106:U7106,2,2)","v":0.06016832492574942},1.2206320790124177,{"$f":"AA7106*7309/AE7106","v":0.26428502817446065},0.5779274390831498,1664]
["Q9Y3B4","Splicing factor 3B subunit 6 [OS=Homo sapiens]",11,1,1,1,125,14.6,9.38,2.98,"RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus","nucleic acid binding activity","SF3B6","ENSG00000115128","Spliceosome","mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway","",30.8,37.4,49.1,52.7,55.7,129.9,0.4922366764582459,-1.0225759381617625,0.19314321507572615,{"$f":"-LOG10(AA7107)","v":0.7141205435736685},0.4515942927026495,{"$f":"-LOG10(AC7107)","v":0.34525155537286367},3126]
["Q9Y3B6","ER membrane protein complex subunit 9 [OS=Homo sapiens]",8,1,3,1,208,23,5.91,12.27,"cell organization and biogenesis","other membranes;ER/Golgi;other cell component","","EMC9","ENSG00000100908; ENSG00000285377","","","",100.6,107.9,104.2,91.2,105.2,167.6,0.8590659340659341,-0.2191592311610181,0.5084542013068712,0.2937481597824801,0.6743407289696829,0.17112060892397785,5511]
["Q9Y3B7-1","39S ribosomal protein L11, mitochondrial [OS=Homo sapiens]",58,12,42,12,192,20.7,9.91,125.25,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus","nucleic acid binding activity;other molecular function","MRPL11","ENSG00000174547; ENSPPAG00000028194; ENSPTRG00000003924","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",6013.7,5689,5560.5,5465.8,6521.3,4421.4,1.05208885638541,0.07325655563120281,0.6702213889813502,0.17378171650619476,0.7874374107160728,0.10378395596489139,6221]
["Q9Y3B8-1","Oligoribonuclease, mitochondrial [OS=Homo sapiens]",32,6,20,6,237,26.8,6.87,64.33,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus;other cell component","nucleic acid binding activity;other molecular function","REXO2","ENSG00000076043; ENSPPAG00000039849; ENSPTRG00000004306","Ribosome biogenesis in eukaryotes","","",1246.9,1474.6,1784.9,2298.5,2291.8,2560.6,0.6301864101022249,-0.6661494517498188,0.007947772857277042,2.0997545532684136,0.10698024275108269,0.9706964209732875,543]
["Q9Y3B9","RRP15-like protein [OS=Homo sapiens]",16,5,12,5,282,31.5,5.52,20.14,"RNA metabolism OR transcription;other metabolic processes","other cell component","","RRP15","ENSG00000067533","","","",1826,1724.2,1682,2733.3,2804.3,1870,0.7063286354554781,-0.5015885085197433,0.07511848101368057,1.1242532026115728,0.2995313571898479,0.5235577056898166,1833]
["Q9Y3C0","WASH complex subunit 3 [OS=Homo sapiens]",17,2,3,2,194,21.2,4.46,8.94,"cell organization and biogenesis;transport","other cytoplasmic organelle;other cell component","","WASHC3","ENSG00000120860","Endocytosis","","",324,350.5,374,473,479.8,205,0.9055968215581275,-0.14305920024492386,0.7112304644612136,0.14798964930437797,0.8136458702061372,0.08956457555254492,6389]
["Q9Y3C1","nucleolar protein 16 [OS=Homo sapiens]",14,3,4,3,178,21.2,9.94,6.24,"other biological processes","nucleus;other cell component","","NOP16","ENSG00000048162","","","",377,369.5,284.7,533.5,442.7,562.8,0.6700454840805719,-0.5776690628539215,0.02230145112656937,1.6516668770524,0.1697930273792662,0.7700801482079954,960]
["Q9Y3C4","EKC/KEOPS complex subunit TPRKB [OS=Homo sapiens]",25,3,10,3,175,19.6,6.79,31.28,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","TPRKB","ENSG00000144034","","tRNA modification in the nucleus and cytosol","",919.6,998.9,967.3,1014.4,967.4,741.5,1.0596702530018727,0.08361539840266737,0.5686800529676472,0.245132004802183,0.7146634297009171,0.14589844076919142,5816]
["Q9Y3C6","Peptidyl-prolyl cis-trans isomerase-like 1 [OS=Homo sapiens]",34,5,30,5,166,18.2,7.99,62.77,"protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","PPIL1","ENSG00000137168","Spliceosome","mRNA Splicing - Major Pathway","",4139.9,3940.3,4335.5,4385.9,4618.2,5330.9,0.8661109173351936,-0.2073763012949134,0.10501928700860731,0.9787309345280955,0.3451375758749599,0.4620077555541423,2224]
["Q9Y3C8","ubiquitin-fold modifier-conjugating enzyme 1 [OS=Homo sapiens]",38,8,27,8,167,19.4,7.4,79.1,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes","","other molecular function","UFC1","ENSG00000143222","","","",3971.4,3922.9,4374.7,5314.4,5642.1,4971.8,0.7702642466553241,-0.3765746335735222,0.007146560463566968,2.14590292758366,0.10201994224259955,0.991314926675518,512]
["Q9Y3D0","Mitotic spindle-associated MMXD complex subunit MIP18 [OS=Homo sapiens]",13,1,2,1,163,17.7,5.19,7.54,"cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","","CIAO2B","ENSG00000166595","","Cytosolic iron-sulfur cluster assembly","",54.2,48.2,66.3,66.6,68,98.4,0.7240343347639484,-0.465869981254077,0.13990220037847004,0.8541754548812054,0.39343793096046076,0.4051237724982451,2599]
["Q9Y3D2","Methionine-R-sulfoxide reductase B2, mitochondrial [OS=Homo sapiens]",16,1,1,1,182,19.5,8.63,5.54,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response","cytosol;mitochondrion;other cell component","cytoskeletal activity;other molecular function","MSRB2","ENSG00000148450","","Protein repair","Sulindac metabolic pathway; Methionine de novo and salvage pathway",66.8,75.6,73.2,61.5,71.3,129.9,0.8207080319756375,-0.2850590223811266,0.5060096263892929,0.2958412210100361,0.6723185528593605,0.17242490407582914,5501]
["Q9Y3D3","28S ribosomal protein S16, mitochondrial [OS=Homo sapiens]",34,4,10,4,137,15.3,9.5,31.7,"protein metabolism;other metabolic processes","other membranes;cytosol;mitochondrion;translational apparatus","other molecular function","MRPS16","ENSG00000182180","Ribosome","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",888.6,834.2,1024.8,1015.8,1111.7,910.5,0.9044107965766953,-0.14494988024740646,0.298967464124045,0.5243760722783718,0.5486199335381986,0.2607284168037269,3983]
["Q9Y3D6","mitochondrial fission 1 protein [OS=Homo sapiens]",20,3,14,3,152,16.9,8.79,36.07,"cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component","other molecular function","FIS1","ENSG00000214253","Mitophagy","Class I peroxisomal membrane protein import","CAMKK2 pathway",989.9,977.8,1052.8,810,942.1,613.5,1.2768430842069667,0.3525812380035974,0.090431309828318,1.0436811786900335,0.3243191577699589,0.48902739647646826,2038]
["Q9Y3D8","Adenylate kinase isoenzyme 6 [OS=Homo sapiens]",47,5,11,5,172,20,4.58,41.12,"other metabolic processes","cytosol;cytoskeleton;nucleus;other cell component","kinase activity;other molecular function","AK6","ENSG00000085231; ENSG00000279247","Purine metabolism; Metabolic pathways; Biosynthesis of cofactors; Ribosome biogenesis in eukaryotes","Interconversion of nucleotide di- and triphosphates","",712.5,751.1,1036.8,1085.3,917.8,1281.6,0.7612262915943617,-0.39360270392997293,0.14925898169091503,0.8260595256495982,0.40330273463175526,0.39436883320821353,2705]
["Q9Y3D9","28S ribosomal protein S23, mitochondrial [OS=Homo sapiens]",19,4,5,4,190,21.8,8.9,13.39,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus","other molecular function","MRPS23","ENSG00000181610","","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",894.5,809,934.3,989.6,990.3,417.1,1.1004589069670423,0.13810527351502577,0.7009933492859697,0.15428610240724408,0.8073684824978179,0.09292820828766456,6346]
["Q9Y3E0","vesicle transport protein GOT1B [OS=Homo sapiens]",25,4,27,4,138,15.4,10.36,67.71,"transport","other membranes;ER/Golgi;other cell component","","GOLT1B","ENSG00000111711","","","",2056.7,2066.1,2172.5,1868.5,1967.7,2015.4,1.0758254152710367,0.10544397663199463,0.06042764923258357,1.218764300425961,0.26447047200057083,0.5776228096895714,1670]
["Q9Y3E1","Hepatoma-derived growth factor-related protein 3 [OS=Homo sapiens]",18,3,6,2,203,22.6,7.99,12.72,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;nucleus","signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function","HDGFL3","ENSG00000166503","","","",196.6,199.9,204.9,165.9,180.7,340.5,0.8752728860427885,-0.19219521512730212,0.6365290068029194,0.19618180063969656,0.7659516810540892,0.11579862633796999,6074]
["Q9Y3E2","BolA-like protein 1 [OS=Homo sapiens]",9,1,1,1,137,14.3,7.96,2.23,"","mitochondrion","","BOLA1","ENSG00000178096","","","",73.6,50,61.7,39.9,54.3,19,1.636925795053004,0.7109889231953839,0.12252989958830626,0.9117579223870845,0.37068337586545136,0.43099689045220574,2416]
["Q9Y3E5","Peptidyl-tRNA hydrolase 2, mitochondrial [OS=Homo sapiens]",56,7,11,7,179,19.2,8.73,36.93,"other biological processes","cytosol;mitochondrion","other molecular function","PTRH2","ENSG00000141378","","Ub-specific processing proteases","",1126.9,1017.9,1078.9,1101,1162.5,819.9,1.0455017188817541,0.06419543382624314,0.6927839113535788,0.15940220657312035,0.8017032311721513,0.09598636602540399,6316]
["Q9Y3E7","Charged multivesicular body protein 3 [OS=Homo sapiens]",9,2,2,2,222,25.1,5.12,5.28,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","CHMP3","ENSG00000115561","Endocytosis; Necroptosis","Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex","",90.3,91.3,98.8,73,85.2,107,1.057315233785822,0.08040557389803545,0.648553589184881,0.1880541328787026,0.7739229687105789,0.11130226403129971,6125]
["Q9Y3F4","Serine-threonine kinase receptor-associated protein [OS=Homo sapiens]",63,16,105,16,350,38.4,5.12,381.28,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","cytosol;nucleus;other cell component","signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function","STRAP","ENSG00000023734","","Downregulation of TGF-beta receptor signaling","TGF-beta signaling pathway; Epithelial to mesenchymal transition in colorectal cancer",10651.7,10725.6,10144.7,11101.9,10678.4,10899.1,0.9645831930818803,-0.052022422117706336,0.15398607961816355,0.8125185377237236,0.4097139628427948,0.38751923526031257,2747]
["Q9Y3I0","tRNA-splicing ligase RtcB homolog [OS=Homo sapiens]",68,26,142,26,505,55.2,7.23,472.97,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","cytoskeletal activity;other molecular function","RTCB","ENSG00000100220","","tRNA processing in the nucleus","Unfolded protein response",17170.2,17293.2,16482.7,17112.9,16675.2,13862.5,1.069159674799478,0.09647732998887344,0.3541757464564433,0.4507811821091711,0.5856720658032001,0.23234548957428997,4420]
["Q9Y3I1","F-box only protein 7 [OS=Homo sapiens]",5,2,4,2,522,58.5,6.55,8.54,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes","cytosol;mitochondrion;nucleus;other cell component","other molecular function","FBXO7","ENSG00000100225","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",456.5,512.2,440.8,552.5,524.8,452.7,0.9212418300653594,-0.11834817500959242,0.3363648324896351,0.4731894167209678,0.5749510198004544,0.2403691513737353,4276]
["Q9Y3L3-1","SH3 domain-binding protein 1 [OS=Homo sapiens]",18,12,33,12,701,75.7,6.77,85.44,"cell organization and biogenesis;transport;signal transduction;other biological processes","plasma membrane;cytosol;nucleus;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","SH3BP1","ENSG00000100092","","RAC1 GTPase cycle","",3338.3,3115.8,3007,3053.2,3248.6,2645.7,1.0574015088013413,0.08052329040786839,0.4456801981651496,0.35097666144591244,0.6323969264975885,0.1990102494425184,5151]
["Q9Y3L5","ras-related protein Rap-2c [OS=Homo sapiens]",46,8,43,4,183,20.7,4.94,126.77,"signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","RAP2C","ENSG00000123728","Tight junction","Neutrophil degranulation","",1488.8,1448.4,1373.3,1119.4,1273.1,966,1.2834598779216913,0.36003819670947634,0.02872380786203077,1.5417579869977465,0.18930776525120188,0.7228315712629336,1109]
["Q9Y3M8-4","Isoform 4 of StAR-related lipid transfer protein 13 [OS=Homo sapiens]",1,1,3,1,1078,120.6,6.95,6.05,"","","","STARD13","","","","",366.9,401.5,339.9,369.8,438,248.1,1.049625911544654,0.06987524053695568,0.7795179377706215,0.10817388665196381,0.8596102304112059,0.06569842451528998,6628]
["Q9Y3P4","rhomboid domain-containing protein 3 [OS=Homo sapiens]",3,1,3,1,386,40.5,6.58,7.94,"protein metabolism;developmental processes;signal transduction;other biological processes","other membranes","other molecular function","RHBDD3","ENSG00000100263","","","",124.3,94.7,108.4,97.9,100.5,223.6,0.7758293838862559,-0.36618867712039416,0.497849929592148,0.30290154995530655,0.6665662457206466,0.17615668237729487,5459]
["Q9Y3P9","Rab GTPase-activating protein 1 [OS=Homo sapiens]",31,26,56,23,1069,121.7,5.25,167.69,"cell cycle OR cell proliferation;transport;other biological processes","cytosol;cytoskeleton","enzyme regulator activity;cytoskeletal activity;other molecular function","RABGAP1","ENSG00000011454","","TBC/RABGAPs","",6215.9,5922,5829.3,5691.8,6178.7,5403.9,1.0401055897744638,0.05672999578116329,0.4153050656487032,0.3816327715872999,0.6168390011839812,0.20982817473740778,4921]
["Q9Y3Q3","Transmembrane emp24 domain-containing protein 3 [OS=Homo sapiens]",12,3,7,3,217,24.8,5.6,19.5,"cell organization and biogenesis;transport","other membranes;ER/Golgi;other cell component","","TMED3","ENSG00000166557","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport","",984,1013.9,1085.4,867.8,797,536,1.4009905488913121,0.4864472233535805,0.049105464963425244,1.3088701724109204,0.24136640445035315,0.6173231790489015,1487]
["Q9Y3Q8","TSC22 domain family protein 4 [OS=Homo sapiens]",32,8,19,6,395,41,7.21,54.61,"stress response;other biological processes","nucleus","","TSC22D4","ENSG00000166925","","","",1708.5,1641.3,1703.5,1834.1,1933.2,1824.7,0.9036659513590845,-0.14613852952757872,0.011766058126929348,1.9293690104324828,0.1279733911454265,0.892880321602335,672]
["Q9Y3R5-1","Protein dopey-2 [OS=Homo sapiens]",3,5,5,5,2298,258.1,6.29,14.93,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","","DOP1B","ENSG00000142197","","","",574.8,614.5,545.2,543.6,547.4,430.1,1.1402932088620077,0.18940483893485757,0.1765859529022232,0.7530438467363086,0.4347142909270291,0.3617960824483803,2969]
["Q9Y3S2","zinc finger protein 330 [OS=Homo sapiens]",27,8,24,8,320,36.2,6.16,60.9,"","nucleus;other cell component","other molecular function","ZNF330","ENSG00000109445","","","",2106.1,2361.7,2021.9,2946.2,2560.4,4084.6,0.6766306614396529,-0.5635595407163476,0.09210790688841457,1.0357030867346055,0.3260129256403981,0.48676518084305237,2065]
["Q9Y3T6","R3H and coiled-coil domain-containing protein 1 [OS=Homo sapiens]",21,7,9,7,440,49.1,5.63,30.34,"","","nucleic acid binding activity","R3HCC1","ENSG00000104679","","","",1183.3,1180.4,1224.3,1403.8,1450.8,1583.1,0.8085269396308898,-0.3066322506573301,0.006973902685530621,2.156524117102275,0.10053699157503611,0.997674114551638,507]
["Q9Y3T9","Nucleolar complex protein 2 homolog [OS=Homo sapiens]",24,16,48,16,749,84.9,5.62,133.65,"cell organization and biogenesis;other biological processes","cytosol;nucleus;other cell component","other molecular function","NOC2L","ENSG00000188976","","Regulation of TP53 Activity through Phosphorylation","",5162.2,5478.3,5429.8,5637.9,5219.9,4016.2,1.0804289363990855,0.11160418420463433,0.4664375802128079,0.3312064663503319,0.6450694936188104,0.190393496109804,5285]
["Q9Y3U8","60S ribosomal protein L36 [OS=Homo sapiens]",21,2,5,2,105,12.2,11.59,14.47,"protein metabolism;other metabolic processes","cytosol;translational apparatus;nucleus","other molecular function","RPL36","ENSG00000130255","Ribosome; Coronavirus disease","Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)","Cytoplasmic ribosomal proteins",468,437.9,450.4,417.6,415.4,464.6,1.0452373612823675,0.06383059882286347,0.3444379479423184,0.4628890068291458,0.5791343366713607,0.2372206851360099,4347]
["Q9Y3X0","coiled-coil domain-containing protein 9 [OS=Homo sapiens]",17,9,13,9,531,59.7,5.4,33.02,"","","","CCDC9","ENSG00000105321","","","IL-18 signaling pathway",2822.8,2546.1,2109.6,3671.6,3065.9,1727.5,0.8834613112817484,-0.17876113752314177,0.6188374680875627,0.20842339941504437,0.7529687122110863,0.12322306947842669,6007]
["Q9Y3Z3","deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [OS=Homo sapiens]",60,33,158,33,626,72.2,7.14,474.84,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","plasma membrane;other membranes;nucleus;other cell component","nucleic acid binding activity;other molecular function","SAMHD1","ENSG00000101347","Human immunodeficiency virus 1 infection","Interferon alpha/beta signaling; Nucleotide catabolism","",20385.9,20262.4,19609.1,18719.7,18668.2,15829.7,1.1322833047713539,0.17923497517677842,0.07575862722521984,1.1205679035126166,0.30077121476867563,0.5217637301326582,1841]
["Q9Y448","Small kinetochore-associated protein [OS=Homo sapiens]",3,1,1,1,316,35.4,6.3,0,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","KNSTRN","ENSG00000128944","","","Overview of leukocyte-intrinsic Hippo pathway functions",151.4,143.9,168.6,182.9,219.5,132.7,0.8669407587366847,-0.2059946827515264,0.4162467054347144,0.3806491908842692,0.6171089594365776,0.20963814827752622,4930]
["Q9Y450-1","HBS1-like protein [OS=Homo sapiens]",41,23,81,23,684,75.4,6.61,246.97,"protein metabolism;other metabolic processes;signal transduction;other biological processes","cytosol","nucleic acid binding activity;other molecular function","HBS1L","ENSG00000112339","mRNA surveillance pathway; Legionellosis","mRNA decay by 3' to 5' exoribonuclease","",7897.8,7992.8,8078.7,8128.4,7925.3,7937.2,0.9990996586205602,-0.001299503129267538,0.9358299386608829,0.028803065163036524,0.9587862379692169,0.01827820828139877,7134]
["Q9Y478","5'-AMP-activated protein kinase subunit beta-1 [OS=Homo sapiens]",24,4,7,4,270,30.4,6.4,23.12,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","kinase activity;other molecular function","PRKAB1","ENSG00000111725","FoxO signaling pathway; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Apelin signaling pathway; Tight junction; Circadian rhythm; Thermogenesis; Insulin signaling pathway; Adipocytokine signaling pathway; Oxytocin signaling pathway; Glucagon signaling pathway; Insulin resistance; Non-alcoholic fatty liver disease; Alcoholic liver disease; Hypertrophic cardiomyopathy","Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Lipophagy","AMP-activated protein kinase (AMPK) signaling; Target of rapamycin (TOR) signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Angiopoietin-like protein 8 regulatory pathway; Leptin and adiponectin; Lipid metabolism pathway; Genotoxicity pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; Malignant pleural mesothelioma",291.3,314.4,286.4,284,271.2,528.7,0.8230464064950641,-0.28095431729902937,0.49007859389088215,0.30973426659183423,0.6616151538139006,0.1793945561423489,5414]
["Q9Y483","Metal-response element-binding transcription factor 2 [OS=Homo sapiens]",8,3,3,3,593,67.1,8.72,9.82,"","","","","","","","",225.7,240.6,214.3,283,283.3,305.6,0.7805941048285353,-0.35735552753293254,0.003948227452928445,2.4035978360666577,0.07757417863831723,1.110282814064582,372]
["Q9Y484-1","WD repeat domain phosphoinositide-interacting protein 4 [OS=Homo sapiens]",3,1,3,1,360,39.8,7.14,9.19,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response","other membranes;cytosol;other cell component","other molecular function","WDR45","ENSCANG00000035794; ENSCSAG00000012964; ENSG00000196998; ENSGGOG00000000589; ENSMFAG00000032970; ENSMLEG00000042347; ENSMMUG00000010620","","Macroautophagy","Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway",350.9,367.8,331.1,393.7,394.5,803.6,0.6595049629350421,-0.6005445787390745,0.2574325259555462,0.5893365819437055,0.5149355041623118,0.28824716307625153,3654]
["Q9Y485","DmX-like protein 1 [OS=Homo sapiens]",10,21,31,21,3027,337.6,6.34,93.99,"other biological processes","other cell component","","DMXL1","ENSG00000172869","","","",1771.3,1929.2,1900.5,2034.3,1931.5,1955.9,0.9458432544708444,-0.08032697552378501,0.1371448501117293,0.8628204958250386,0.38988397878904296,0.40906461058392624,2571]
["Q9Y487","V-type proton ATPase 116 kDa subunit a isoform 2 [OS=Homo sapiens]",11,8,18,7,856,98,6.61,37.74,"transport;other biological processes","plasma membrane;other membranes;other cytoplasmic organelle;other cell component","transporter activity;other molecular function","ATP6V0A2","ENSG00000185344","Oxidative phosphorylation; Metabolic pathways; Lysosome; Phagosome; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Tuberculosis; Human papillomavirus infection; Rheumatoid arthritis","ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","",798.9,843.6,818.9,784.2,770.8,1132,0.9160401935243767,-0.1265171933706953,0.5615417192940712,0.2506179726418126,0.711195360651597,0.14801108506650237,5771]
["Q9Y490","Talin-1 [OS=Homo sapiens]",70,136,676,115,2541,269.6,6.07,2295.38,"cell adhesion;cell organization and biogenesis;signal transduction","non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","TLN1","ENSG00000137076","Rap1 signaling pathway; Focal adhesion; Platelet activation; Shigellosis; Human T-cell leukemia virus 1 infection","Platelet degranulation ; p130Cas linkage to MAPK signaling for integrins; Signaling by BRAF and RAF1 fusions; XBP1(S) activates chaperone genes; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Smooth Muscle Contraction; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins","Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion",76301.2,73669.2,74238,73253.2,73499.4,77350.4,1.0004703194513238,6.7836802772084617E-4,0.9829901387048661,7.450838960888724E-3,0.990579749592426,0.004110554538662085,7253]
["Q9Y496","kinesin-like protein KIF3A [OS=Homo sapiens]",11,7,14,7,699,80,6.54,27.19,"cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","KIF3A","ENSG00000131437","Hedgehog signaling pathway","Translocation of SLC2A4 (GLUT4) to the plasma membrane; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Hedgehog 'off' state; Activation of SMO","Hedgehog signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Insulin signaling",1060.8,934.3,910.8,878.7,984.9,1451.3,0.8766176958580953,-0.18998029274275224,0.4952843855497316,0.30514536347016324,0.6653250457605198,0.17696612749209484,5441]
["Q9Y4A5","Transformation/transcription domain-associated protein [OS=Homo sapiens]",9,29,55,29,3859,437.3,8.19,157.22,"protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","ER/Golgi;nucleus","other molecular function","TRRAP","ENSG00000196367","Human T-cell leukemia virus 1 infection","Ub-specific processing proteases; HATs acetylate histones; Formation of the beta-catenin:TCF transactivating complex","Rett syndrome causing genes",3429.1,3540.4,3332.2,4027.6,3916.3,5737.7,0.7529601800958953,-0.4093545241431561,0.13002501321943125,0.8859730933991157,0.3802932459467079,0.4198813876415927,2499]
["Q9Y4B4","Helicase ARIP4 [OS=Homo sapiens]",5,5,5,5,1467,162.7,6.09,13.39,"cell organization and biogenesis","nucleus","nucleic acid binding activity;other molecular function","RAD54L2","ENSG00000164080","","","",146.1,306.8,169,213.9,197.5,1260.7,0.37192751629687215,-1.4269066081460366,0.38022459469068093,0.41995979438014924,0.5961093012857543,0.22467410168073418,4662]
["Q9Y4B5","Microtubule cross-linking factor 1 [OS=Homo sapiens]",11,17,21,15,1905,209.4,6.43,59.89,"cell organization and biogenesis;other biological processes","non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MTCL1","ENSG00000168502","","","",1478.4,1544.4,1578.4,1862.9,1685.3,2081,0.8173808001136931,-0.2909197393512559,0.044088295348218946,1.3556766926269312,0.23033691972847195,0.6376364452347859,1399]
["Q9Y4B6","DDB1- and CUL4-associated factor 1 [OS=Homo sapiens]",14,17,24,17,1507,168.9,5.06,59.02,"protein metabolism;DNA metabolism;other metabolic processes;developmental processes;other biological processes","nucleus;other cell component","kinase activity;other molecular function","DCAF1","ENSG00000145041","Human immunodeficiency virus 1 infection","Antigen processing: Ubiquitination & Proteasome degradation","Hippo-Merlin signaling dysregulation",1821.3,1842.3,1773.6,2579.6,2545.3,2725.4,0.6926104734850898,-0.5298838911079905,1.6577473208967641E-4,3.7804816652833595,0.023757794447910683,1.6241938794973227,51]
["Q9Y4C1","Lysine-specific demethylase 3A [OS=Homo sapiens]",4,4,5,4,1321,147.2,8.07,17.37,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","KDM3A","ENSG00000115548","Thermogenesis","NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; HDMs demethylate histones","Thermogenesis; Male infertility; Vitamin D-sensitive calcium signaling in depression",359.7,367,369.9,360.8,345.1,322.8,1.0660056381841156,0.09221506864000821,0.11888799055134926,0.9248620133434545,0.3668013182523477,0.4355691121822467,2369]
["Q9Y4C2-1","TRPM8 channel-associated factor 1 [OS=Homo sapiens]",12,8,10,8,921,102.1,6.54,20.97,"other biological processes","plasma membrane;other membranes","other molecular function","TCAF1","ENSG00000198420","","","",803.8,787.2,752.3,703.6,754.2,665.7,1.103508358841535,0.14209755776755595,0.06973841938771942,1.1565279000769133,0.28781372518624576,0.5408884993830151,1771]
["Q9Y4C8","Probable RNA-binding protein 19 [OS=Homo sapiens]",6,5,6,5,960,107.3,6.54,18.91,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus;other cell component","","RBM19","ENSG00000122965","","","",317.7,293.8,303.4,429.6,476.6,568.1,0.620565692192905,-0.6883441548227168,0.010656979259725018,1.9723658794317778,0.12305191375881543,0.90991162756516,633]
["Q9Y4D1","Disheveled-associated activator of morphogenesis 1 [OS=Homo sapiens]",8,9,12,9,1078,123.4,7.23,24.91,"cell-cell signaling;cell organization and biogenesis;signal transduction","plasma membrane;other membranes;cytosol;cytoskeleton","cytoskeletal activity;other molecular function","DAAM1","ENSG00000100592","Wnt signaling pathway","RHO GTPases Activate Formins; RHOA GTPase cycle; PCP/CE pathway; RHOC GTPase cycle; CDC42 GTPase cycle; RHOB GTPase cycle","Physico-chemical features and toxicity-associated pathways; Wnt signaling; Genotoxicity pathway",1514.1,1365,1379.1,1127.9,1187.2,1162.8,1.224359527300957,0.2920272607197323,0.006763073784348931,2.1698558744464904,0.09925965118435007,1.003227255322235,498]
["Q9Y4D8-1","Probable E3 ubiquitin-protein ligase HECTD4 [OS=Homo sapiens]",1,2,2,1,3996,439.1,6.19,7.94,"protein metabolism;other metabolic processes;other biological processes","other membranes","other molecular function","HECTD4","","","","",13.6,18.3,17.7,18.2,16.3,26.2,0.8171334431630971,-0.291356395868807,0.33436382791860014,0.47578071145147927,0.5744864170797012,0.24072023513421645,4254]
["Q9Y4D8-5","Isoform 5 of Probable E3 ubiquitin-protein ligase HECTD4 [OS=Homo sapiens]",3,3,3,2,1321,145,5.78,9.3,"","","","HECTD4","","","","",101,137.3,106.2,111.9,93.2,410,0.5600715330840513,-0.8363169930119569,0.4316401367652982,0.36487817852751403,0.6241063817245429,0.204741376570561,5055]
["Q9Y4E1","WASH complex subunit 2C [OS=Homo sapiens]",31,32,65,7,1318,144.6,4.79,199.88,"","","","","","","","",372.1,376,361.5,451,478.4,851.4,0.6230907457322551,-0.682485805018357,0.1584081626801643,0.8002224432287522,0.4149839645266383,0.3819686846183768,2790]
["Q9Y4E5","E3 SUMO-protein ligase ZNF451 [OS=Homo sapiens]",13,11,16,11,1061,121.4,6.77,39.08,"protein metabolism;other metabolic processes;other biological processes","nucleus","other molecular function","ZNF451","ENSG00000112200","","","",896.3,1078.4,1022.9,1007.2,845,1862.8,0.8068909825033648,-0.30955432798420734,0.4967893732397905,0.30382770267181464,0.6658781457930733,0.176605238474663,5453]
["Q9Y4E6-1","WD repeat-containing protein 7 [OS=Homo sapiens]",5,5,8,5,1490,163.7,6.92,26.64,"","ER/Golgi","","WDR7","ENSG00000091157","","","",558.5,541.9,568,513.2,514.9,772.1,0.9267859126763693,-0.10969197975929604,0.6377052156283878,0.1953800310143671,0.7661057562504743,0.11571127451135502,6084]
["Q9Y4E8-3","Isoform 3 of Ubiquitin carboxyl-terminal hydrolase 15 [OS=Homo sapiens]",36,27,68,26,956,109.7,5.16,185.84,"","","","USP15","","","","",6729.9,6595,6810.3,6525.1,6498.2,6906.4,1.01031124402274,0.014799808853516474,0.663400862557519,0.1782239681440504,0.7838339645058043,0.10577592192723764,6186]
["Q9Y4F1","FERM, RhoGEF and pleckstrin domain-containing protein 1 [OS=Homo sapiens]",6,5,7,5,1045,118.6,8.15,21.83,"cell-cell signaling;cell organization and biogenesis;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","FARP1","ENSG00000152767","","RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOF GTPase cycle","",357.9,311.2,312.4,281.2,288.3,566.1,0.8643008101444171,-0.21039458137085817,0.6176182581240186,0.20927987380362703,0.7517355284976606,0.12393492365857896,6005]
["Q9Y4F3-1","Meiosis regulator and mRNA stability factor 1 [OS=Homo sapiens]",1,2,2,2,1742,192.7,7.87,4.99,"cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes","ER/Golgi;other cytoplasmic organelle;other cell component","nucleic acid binding activity;other molecular function","MARF1","ENSG00000166783; ENSG00000277140","","","",178.4,214.2,197.5,240,228.1,183,0.906312394409461,-0.14191968017561,0.3712295705561241,0.4303574370386942,0.5925566567361238,0.22727011868241861,4579]
["Q9Y4G6","Talin-2 [OS=Homo sapiens]",8,22,62,2,2542,271.4,5.57,173.61,"cell adhesion;cell organization and biogenesis","plasma membrane;other membranes;cytoskeleton;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","TLN2","ENSG00000171914","Rap1 signaling pathway; Focal adhesion; Platelet activation; Shigellosis; Human T-cell leukemia virus 1 infection","","Focal adhesion",410.6,443.5,502.7,480.9,430.4,362.1,{"$f":"AVERAGE(S7170:U7170)/AVERAGE(V7170:X7170)","v":1.0654939531961676},{"$f":"LOG(Y7170,2)","v":0.09152240567936232},{"$f":"TTEST(V7170:X7170,S7170:U7170,2,2)","v":0.5593830184543658},0.2522907219178445,{"$f":"AA7170*7309/AE7170","v":0.7096911095092796},0.1489306352603982,5761]
["Q9Y4G8","rap guanine nucleotide exchange factor 2 [OS=Homo sapiens]",6,7,11,5,1499,167.3,6.67,18.79,"cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","RAPGEF2","ENSG00000109756","MAPK signaling pathway; Rap1 signaling pathway; Tight junction","RAF/MAP kinase cascade","MAPK signaling pathway; Genotoxicity pathway",653.8,540.1,517.6,543.4,520.3,641.7,1.0035768734607717,0.005151130614722441,0.9728881094500514,{"$f":"-LOG10(AA7171)","v":0.011937104482569115},0.9836546122520994,{"$f":"-LOG10(AC7171)","v":0.00715736734556547},7229]
["Q9Y4H2","Insulin receptor substrate 2 [OS=Homo sapiens]",1,2,3,2,1338,137.2,8.65,4.13,"other metabolic processes;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;other cell component","signal transduction activity or receptor binding;other molecular function","IRS2","ENSG00000185950","cGMP-PKG signaling pathway; FoxO signaling pathway; Autophagy; AMPK signaling pathway; Longevity regulating pathway; Longevity regulating pathway; Insulin signaling pathway; Adipocytokine signaling pathway; Regulation of lipolysis in adipocytes; Type II diabetes mellitus; Insulin resistance; Non-alcoholic fatty liver disease; Growth hormone synthesis, secretion and action; Alzheimer disease; MicroRNAs in cancer","Growth hormone receptor signaling; Interleukin-7 signaling; Signaling by Leptin; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); RAF/MAP kinase cascade; PI3K Cascade; PI3K/AKT activation; Erythropoietin activates Phospholipase C gamma (PLCG); Erythropoietin activates STAT5; Erythropoietin activates RAS; SOS-mediated signalling; IRS activation; Signal attenuation","Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Farnesoid X receptor pathway; Nuclear receptors meta-pathway; Transcription factor regulation in adipogenesis; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; Nonalcoholic fatty liver disease; Insulin signaling; FOXA2 pathway; Alzheimer's disease; EPO receptor signaling; Interferon type I signaling pathways",270.4,288.6,282.5,347.4,334,420.8,0.7634730538922155,-0.3893508556151944,0.03419822484563112,1.4659964366267737,0.2052174264340869,0.6877857630396572,1218]
["Q9Y4I1-1","Unconventional myosin-Va [OS=Homo sapiens]",33,53,123,1,1855,215.3,8.48,353.17,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;cytoskeleton;other cell component","cytoskeletal activity;other molecular function","MYO5A","ENSG00000197535","Pathogenic Escherichia coli infection","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Insulin processing; Translocation of SLC2A4 (GLUT4) to the plasma membrane","Joubert syndrome",115.2,144.1,134.7,118.4,109.5,173.9,0.9805873568939771,-0.02828193438955325,0.9111049816331747,0.040431578771046174,0.9421712380810516,0.02587015772179972,7068]
["Q9Y4I1-3","Isoform 3 of Unconventional myosin-Va [OS=Homo sapiens]",32,53,122,1,1880,218.5,8.51,350.7,"","","","MYO5A","","","","",11346.5,11452.8,11249.6,11176,11246,10427.1,1.0365245927590103,0.0517543464816375,0.2106897198930281,0.6763566542478521,0.46992101394511515,0.327975133746255,3277]
["Q9Y4J8-1","Dystrobrevin alpha [OS=Homo sapiens]",11,7,7,7,743,83.8,6.89,19.38,"cell-cell signaling;signal transduction;other biological processes","plasma membrane;other membranes;cytoskeleton;nucleus;other cell component","other molecular function","DTNA","ENSG00000134769","","","",550.2,506.6,522.7,578,597.4,532.9,0.9246034068957444,-0.11309341639036292,0.13481506851021177,0.8702615632525145,0.3862655177346679,0.4131140599783315,2551]
["Q9Y4K3","TNF receptor-associated factor 6 [OS=Homo sapiens]",20,7,9,7,522,59.5,6.44,27.18,"protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;other molecular function","TRAF6","ENSG00000175104","MAPK signaling pathway; NF-kappa B signaling pathway; Ubiquitin mediated proteolysis; Autophagy; Endocytosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; IL-17 signaling pathway; Neurotrophin signaling pathway; Alcoholic liver disease; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Pertussis; Yersinia infection; Leishmaniasis; Chagas disease; Toxoplasmosis; Tuberculosis; Hepatitis C; Hepatitis B; Measles; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Lipid and atherosclerosis","Ub-specific processing proteases; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; TRAF6 mediated NF-kB activation; activated TAK1 mediates p38 MAPK activation; Ovarian tumor domain proteases; NRIF signals cell death from the nucleus; Regulated proteolysis of p75NTR; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; PIP3 activates AKT signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; TICAM1,TRAF6-dependent induction of TAK1 complex; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway; TRAF6 mediated IRF7 activation; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling","Regulation of toll-like receptor signaling pathway; IL-1 signaling pathway; RANKL/RANK signaling pathway; IL-17 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Melatonin metabolism and effects; Photodynamic therapy-induced NF-kB survival signaling; Interleukin-1 induced activation of NF-kB; TGF-beta signaling pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor (RLR) pathway; MYD88 distinct input-output pathway; ApoE and miR-146 in inflammation and atherosclerosis; Oxidative damage response; Fibrin complement receptor 3 signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; miRNAs involvement in the immune response in sepsis; Signal transduction through IL1R; Interactions between immune cells and microRNAs in tumor microenvironment; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; 16p11.2 proximal deletion syndrome; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Modulators of TCR signaling and T cell activation; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; T-cell receptor (TCR) signaling pathway; Toll-like receptor signaling pathway",938.1,1014,1085.1,910.3,853.5,560.1,1.3069409182839193,0.38619392397544094,0.11086733942759973,0.9551963744590629,0.35293091632244183,0.45231029630102587,2296]
["Q9Y4K4","mitogen-activated protein kinase kinase kinase kinase 5 [OS=Homo sapiens]",2,1,1,1,846,95,7.64,3.44,"","","","","","","","",76.9,76.8,93,81.3,95.1,119.7,0.833164471462344,-0.2633267748774305,0.25663857626818054,0.5906780626874985,0.5139099599846936,0.2891129652600002,3650]
["Q9Y4L1","Hypoxia up-regulated protein 1 [OS=Homo sapiens]",63,51,778,51,999,111.3,5.22,2458.55,"stress response;transport;other biological processes","non-structural extracellular;ER/Golgi;other cell component","other molecular function","HYOU1","ENSG00000149428; ENSG00000280682","Protein processing in endoplasmic reticulum","XBP1(S) activates chaperone genes; Scavenging by Class F Receptors","VEGFA-VEGFR2 signaling pathway",74936.7,73552.2,70985.1,68812.9,71997.1,62815.2,1.0778331954983962,0.10813392517062435,0.1457330189615505,0.8364420382906557,0.3987879579146284,0.39925796442805556,2671]
["Q9Y4L5","E3 ubiquitin-protein ligase RNF115 [OS=Homo sapiens]",3,1,1,1,304,33.7,5.69,1.74,"protein metabolism;other metabolic processes;other biological processes","cytosol","other molecular function","RNF115","ENSG00000265491","","Antigen processing: Ubiquitination & Proteasome degradation","",55.7,67.8,70.7,97.7,110.1,177.6,0.5038920601971977,-0.9888133708765289,0.06505510072051456,1.186718646405582,0.2756450615456469,0.5596497839309018,1725]
["Q9Y4P1-1","Cysteine protease ATG4B [OS=Homo sapiens]",23,6,17,6,393,44.3,5.07,57.73,"protein metabolism;other metabolic processes;transport;other biological processes","cytosol","other molecular function","ATG4B","ENSG00000168397","Autophagy; Autophagy","Macroautophagy","",1456.4,1304.9,1150.8,1364.8,1383.3,1917.9,0.8384269181311618,-0.2542430587957216,0.2807478525592646,0.5516835569729281,0.5327066600092588,0.27351187354145207,3852]
["Q9Y4P3","Transducin beta-like protein 2 [OS=Homo sapiens]",37,17,53,17,447,49.8,9.44,156.95,"stress response;signal transduction","other membranes;ER/Golgi","other molecular function","TBL2","ENSG00000106638","","","7q11.23 copy number variation syndrome",7674,7812,7562.2,6861.3,6903.2,6922.4,1.1141447002692524,0.15593661580538162,4.5318635971012888E-4,3.343723170282101,0.030669806510382706,1.5132889638850777,108]
["Q9Y4P8-1","WD repeat domain phosphoinositide-interacting protein 2 [OS=Homo sapiens]",28,8,18,1,454,49.4,6.46,61,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response","other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","WIPI2","ENSG00000157954","Autophagy; Autophagy; Alzheimer disease; Amyotrophic lateral sclerosis; Huntington disease; Spinocerebellar ataxia; Pathways of neurodegeneration; Shigellosis","Macroautophagy","Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Alzheimer's disease",952.5,1036.6,1083.1,982.1,906.8,1595.2,0.8817772164978042,-0.1815138940397054,0.5686251701929366,0.24517392017501607,0.7147173463353694,0.14586567735551034,5815]
["Q9Y4P8-6","Isoform 6 of WD repeat domain phosphoinositide-interacting protein 2 [OS=Homo sapiens]",28,8,16,1,443,48.2,6.3,47.61,"","","","WIPI2","","","","",42.2,34.8,35.2,34.5,40.8,48.8,0.9041095890410958,-0.14543043952156387,0.4537011746270182,0.3432300963492094,0.6370993055425314,0.19579286831179143,5205]
["Q9Y4R8","telomere length regulation protein TEL2 homolog [OS=Homo sapiens]",16,9,19,9,837,91.7,5.76,60.21,"cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","TELO2","ENSG00000100726","Fanconi anemia pathway; mTOR signaling pathway","","Fragile X syndrome; Malignant pleural mesothelioma",816.3,835.8,855,872.8,862.6,1042.5,0.9025162892832714,-0.147975123822604,0.20323600248724613,0.691999355952276,0.4617506814358974,0.3355924549702729,3217]
["Q9Y4W2","Ribosomal biogenesis protein LAS1L [OS=Homo sapiens]",42,26,58,26,734,83,4.73,167.39,"RNA metabolism OR transcription;other metabolic processes","cytosol;nucleus;other cell component","other molecular function","LAS1L","ENSG00000001497","","Major pathway of rRNA processing in the nucleolus and cytosol","",5949,5815,5313.5,5615.1,6194.5,5392.5,0.9927566983100902,-0.01048790497881925,0.8990754533930483,0.04620385930441079,0.9343583803284218,0.029486514833844003,7033]
["Q9Y4W6","AFG3-like protein 2 [OS=Homo sapiens]",41,33,106,33,797,88.5,8.66,305.32,"cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes","other membranes;mitochondrion","other molecular function","AFG3L2","ENSG00000141385","Spinocerebellar ataxia","Processing of SMDT1","Ciliary landscape",13928.7,13874.1,13402.7,11146.1,11958.6,9982.4,1.2453645076177724,0.31656806869149856,0.010571815697728656,1.9758504166864812,0.12245546899318344,0.9120218140466425,631]
["Q9Y4X4-1","Krueppel-like factor 12 [OS=Homo sapiens]",4,2,2,1,402,44.2,9.7,3.52,"other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","KLF12","ENSCANG00000041690; ENSG00000118922; ENSGGOG00000004142; ENSMFAG00000002684; ENSMLEG00000030485; ENSMMUG00000019097; ENSMNEG00000039444; ENSNLEG00000016131; ENSPANG00000007736; ENSPPAG00000031325; ENSRBIG00000037086; ENSRROG00000027231","","","",33.6,23.1,34.7,44.3,53.6,6.6,0.8746411483253589,-0.19323687191017533,0.7831717526386677,0.10614298501286919,0.8613003821901929,0.06484536007158846,6646]
["Q9Y4X5","E3 ubiquitin-protein ligase ARIH1 [OS=Homo sapiens]",38,15,49,15,557,64.1,5.08,160.36,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","ARIH1","ENSG00000166233","","ISG15 antiviral mechanism","",5378.8,5329.4,5395.4,5067.9,5179.7,4156.1,1.118018286967932,0.1609437859469199,0.1559873210458979,0.8069107005146554,0.4120387891306353,0.38506189777163435,2767]
["Q9Y4Y9","U6 snRNA-associated Sm-like protein LSm5 [OS=Homo sapiens]",25,1,2,1,91,9.9,4.54,4.63,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LSM5","ENSG00000106355","RNA degradation; Spliceosome","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease","",17,14.3,15.8,19,16.5,4.1,1.1893939393939394,0.25022662953317365,0.6209865722704959,0.20691779056718232,0.7539519695556568,0.12265631994103399,6020]
["Q9Y4Z0","U6 snRNA-associated Sm-like protein LSm4 [OS=Homo sapiens]",12,2,4,2,139,15.3,9.99,6.58,"cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes","other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","LSM4","ENSG00000130520","RNA degradation; Spliceosome","mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease","Ciliary landscape",453.6,426.2,417.5,525.8,525.5,843.3,0.6847355642351948,-0.5463811488903754,0.13474898219426545,0.8704745065054801,0.38637909409881765,0.41298638009077465,2549]
["Q9Y508-1","E3 ubiquitin-protein ligase RNF114 [OS=Homo sapiens]",18,4,6,4,228,25.7,7.25,19.78,"protein metabolism;other metabolic processes;other biological processes","plasma membrane;other membranes;cytosol;nucleus","other molecular function","RNF114","ENSG00000124226; ENSPPAG00000043607; ENSPTRG00000013613","","Antigen processing: Ubiquitination & Proteasome degradation","",989.2,901.1,1019.4,879,1014.2,967.6,1.0170931208053693,0.024451772385080298,0.7746456109023819,0.1108969354676142,0.8557866943901918,0.06763447012813152,6616]
["Q9Y512","sorting and assembly machinery component 50 homolog [OS=Homo sapiens]",42,16,73,16,469,51.9,6.9,220.8,"cell organization and biogenesis;transport","other membranes;mitochondrion","","SAMM50","ENSG00000100347","","RAC2 GTPase cycle; Mitochondrial protein import; Cristae formation","",7560.8,7303,7761.2,6283.9,6496.4,4590.5,1.3024731158035325,0.3812535943101523,0.04702776445757921,1.3276456656684075,0.23672584739700167,0.6257543201485095,1452]
["Q9Y519","Transmembrane protein 184B [OS=Homo sapiens]",2,1,1,1,407,45.5,6.89,2.07,"","other membranes","","TMEM184B","ENSG00000198792","","","",52.2,55.8,48.2,46.4,60.4,34.5,1.105449398443029,0.14463298780803982,0.558906146607481,0.25266111417541237,0.7093323538034517,0.1491502308213457,5759]
["Q9Y520-7","Isoform 7 of Protein PRRC2C [OS=Homo sapiens]",23,56,122,54,2898,316.9,9.13,331.37,"","","","PRRC2C","","","","",13937,14270.9,14414.8,20416.6,21211.3,19705.6,0.6949334376808759,-0.5250532950749708,1.6740621283426526E-4,3.7762284283644463,0.02353023095395471,1.6283738101152725,52]
["Q9Y535","DNA-directed RNA polymerase III subunit RPC8 [OS=Homo sapiens]",27,3,6,3,204,22.9,4.58,24.95,"RNA metabolism OR transcription;other metabolic processes;stress response","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","POLR3H","ENSG00000100413","RNA polymerase; Cytosolic DNA-sensing pathway","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation","Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway",421.5,390.9,400.4,428.3,476.3,650.8,0.7797351163687797,-0.3589439852756045,0.1693668212336649,0.7711716634647666,0.4253959094147274,0.3712066905667009,2910]
["Q9Y547","Intraflagellar transport protein 25 homolog [OS=Homo sapiens]",42,4,11,4,144,16.3,5.03,43.54,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","cytoskeleton;other cell component","other molecular function","HSPB11","ENSG00000081870","","Intraflagellar transport","Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); GDNF/RET signaling axis",690.4,810.7,761.1,737.8,630.3,562.4,1.1718207718207718,0.2287519286522973,0.14836578047556634,0.8286662544770469,0.40237680500776046,0.3953670621158314,2695]
["Q9Y548","Protein YIPF1 [OS=Homo sapiens]",8,3,3,3,306,34.3,5.31,9.76,"transport","plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle","other molecular function","YIPF1","ENSG00000058799","","","",479.1,452.9,448.7,407.1,437.9,248.1,1.2631049309303817,0.3369744942677683,0.18285318633571046,0.7378974673961606,0.4409349847996396,0.3556254418798099,3031]
["Q9Y570","Protein phosphatase methylesterase 1 [OS=Homo sapiens]",38,11,21,11,386,42.3,5.97,56.27,"cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes","nucleus","enzyme regulator activity;other molecular function","PPME1","ENSG00000214517","","Cyclin A/B1/B2 associated events during G2/M transition","",2635.9,2570.7,2542.1,2407.3,2241.3,2353.2,1.1066725699105944,0.14622843653600617,0.011428778214386268,1.9420001950738,0.12675711679658458,0.8970276477838368,659]
["Q9Y572-1","Receptor-interacting serine/threonine-protein kinase 3 [OS=Homo sapiens]",7,3,3,3,518,56.9,6.47,9.74,"cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;kinase activity;other molecular function","RIPK3","ENSG00000129465; ENSG00000285379","Necroptosis; NOD-like receptor signaling pathway; Cytosolic DNA-sensing pathway; TNF signaling pathway; Salmonella infection","Regulation of necroptotic cell death; IKK complex recruitment mediated by RIP1; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; TRIF-mediated programmed cell death; TLR3-mediated TICAM1-dependent programmed cell death; TRP channels; Microbial modulation of RIPK1-mediated regulated necrosis","TNF-alpha signaling pathway; Nanoparticle triggered regulated necrosis; Cytosolic DNA-sensing pathway",151.9,165.9,159.3,165.4,163.6,189.6,0.9199768607790204,-0.12033051986898975,0.21138983959084395,0.674915890801886,0.4706208765060854,0.32732881164725314,3283]
["Q9Y575","Ankyrin repeat and SOCS box protein 3 [OS=Homo sapiens]",2,1,1,1,518,57.7,6.27,2.27,"protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol","","ASB3","ENSG00000115239","","Antigen processing: Ubiquitination & Proteasome degradation; Neddylation","",89.6,98,81,155.4,146.1,289.7,0.4543301759133965,-1.1381869647187086,0.08248893130932343,1.0836043228898835,0.3128757648883471,0.5046280756613636,1927]
["Q9Y580","RNA-binding protein 7 [OS=Homo sapiens]",6,2,5,2,266,30.5,9.57,13.63,"cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","RBM7","ENSG00000076053","","","",488.3,433.9,475.5,584.2,643.4,620,0.7564949123186837,-0.4025977150194232,3.2374853383724056E-3,2.4897921896993798,0.07084664771905363,1.1496806946269715,334]
["Q9Y587-1","AP-4 complex subunit sigma-1 [OS=Homo sapiens]",7,1,1,1,144,17,5.19,2.06,"transport;other biological processes","other membranes;ER/Golgi;other cytoplasmic organelle;other cell component","","AP4S1","ENSCANG00000008358; ENSCATG00000035780; ENSG00000100478; ENSGGOG00000003198; ENSMMUG00000003123; ENSPANG00000017427; ENSPCOG00000016646; ENSPPAG00000041450; ENSPTRG00000006239; ENSRROG00000019504","Lysosome","Lysosome Vesicle Biogenesis","",35.2,30.9,30.9,30.7,30,18.3,1.2278481012658229,0.2961320940100249,0.23263650963690669,0.6333221267117143,0.493281186230389,0.30690544823568894,3447]
["Q9Y592","Centrosomal protein of 83 kDa [OS=Homo sapiens]",2,2,2,2,693,82,6.28,4.99,"","","","","","","","",43.7,47,50.2,76.9,55.6,32.7,0.852905569007264,-0.22954207510980867,0.5641144226390126,0.2486327965829458,0.7119862398667833,0.14752839963234685,5791]
["Q9Y597","BTB/POZ domain-containing protein KCTD3 [OS=Homo sapiens]",1,1,1,1,815,88.9,7.03,3.19,"cell organization and biogenesis","plasma membrane;other membranes","","KCTD3","ENSG00000136636","","CDC42 GTPase cycle","",148.7,142.3,132.3,203.7,200.9,316.9,0.5866943866943867,-0.7693189060601402,0.06123328871294188,1.2130124148819572,0.2660844870409585,0.5749804444598777,1682]
["Q9Y5A7","NEDD8 ultimate buster 1 [OS=Homo sapiens]",25,15,24,15,615,70.5,5.96,68.07,"protein metabolism;other metabolic processes;stress response;other biological processes","cytosol;nucleus","","NUB1","ENSG00000013374","","","",3345.3,3448.5,3389,3527.5,3518,3302.6,0.9840260530918719,-0.02323158199676351,0.525367078325243,0.2795371453863574,0.6850861686849601,0.1642548004333763,5605]
["Q9Y5A9-1","YTH domain-containing family protein 2 [OS=Homo sapiens]",16,9,24,6,579,62.3,8.79,62.04,"cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity","YTHDF2","ENSCSAG00000001018; ENSG00000198492; ENSMFAG00000026128; ENSMMUG00000011391; ENSMNEG00000041161; ENSNLEG00000009856; ENSPTRG00000000439; ENSRBIG00000043898; ENSRROG00000038863","","","",1200.7,1310.9,1233.3,1897.1,1811.7,1087.1,0.780854479868221,-0.3568743822865388,0.24761233061838486,0.6062277320825196,0.5065207177413308,0.29540278640098655,3573]
["Q9Y5B0","RNA polymerase II subunit A C-terminal domain phosphatase [OS=Homo sapiens]",12,10,17,10,961,104.3,5.27,44.42,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","cytoskeleton;nucleus;other cell component","other molecular function","CTDP1","ENSG00000060069","","Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; Abortive elongation of HIV-1 transcript in the absence of Tat","",1275.4,1291.2,1254.2,1329.1,1355.8,2080.4,0.8017963192243932,-0.31869230030826134,0.2703565043019516,0.568063177601335,0.5244256077343323,0.28031610983820177,3768]
["Q9Y5B6","PAX3- and PAX7-binding protein 1 [OS=Homo sapiens]",14,11,23,11,917,104.7,5.68,71.3,"RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes","nucleus","nucleic acid binding activity","PAXBP1","ENSG00000159086; ENSG00000263141","","","",2560.4,2439.5,2502,2689.1,2771.9,1931.6,1.0147850553255957,0.02117417819362773,0.8990446582655583,0.046218735011381615,0.9344592444913205,0.02943963519312417,7032]
["Q9Y5B8","Nucleoside diphosphate kinase 7 [OS=Homo sapiens]",11,4,5,4,376,42.5,6.47,11.96,"other metabolic processes","cytosol;cytoskeleton","kinase activity;other molecular function","NME7","ENSG00000143156","Purine metabolism; Pyrimidine metabolism; Drug metabolism; Metabolic pathways; Biosynthesis of cofactors","Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes","Pyrimidine metabolism; Ciliopathies",407.4,411.3,391.4,407.5,395.5,324.7,1.0730690786556707,0.10174295235363173,0.35918825731329096,0.44467786985384616,0.5879746859356872,0.23064137119443842,4465]
["Q9Y5B9","FACT complex subunit SPT16 [OS=Homo sapiens]",41,44,216,44,1047,119.8,5.66,598.2,"cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes","nucleus","other molecular function","SUPT16H","ENSG00000092201","","Regulation of TP53 Activity through Phosphorylation; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes","",29578.7,28290.9,30002.2,26839.8,27284.2,20747.8,1.1736301250938272,0.23097780813286767,0.11658828985881743,0.9333450679740113,0.36338755248532906,0.4396299531411404,2345]
["Q9Y5J1","U3 small nucleolar RNA-associated protein 18 homolog [OS=Homo sapiens]",23,8,18,8,556,62,8.76,49.37,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","","UTP18","ENSG00000011260","Ribosome biogenesis in eukaryotes","rRNA modification in the nucleus and cytosol; Major pathway of rRNA processing in the nucleolus and cytosol","",922.8,916.1,886.4,1495.9,1639.9,1342.2,0.6085975882090219,-0.7164394782313342,0.002525020234449053,2.5977351372782476,0.06385942177712155,1.1947750181508225,289]
["Q9Y5J6","Mitochondrial import inner membrane translocase subunit Tim10 B [OS=Homo sapiens]",24,1,1,1,103,11.6,7.43,2.04,"cell adhesion;cell organization and biogenesis;transport","other membranes;mitochondrion","transporter activity;other molecular function","TIMM10B","ENSG00000132286","","Mitochondrial protein import","",56,47,62.7,47.6,58.8,23,1.2805255023183924,0.35673598522894406,0.3524518866072041,0.45290016039499875,0.5838782500480633,0.23367770227917875,4412]
["Q9Y5J9","mitochondrial import inner membrane translocase subunit Tim8 B [OS=Homo sapiens]",13,1,2,1,83,9.3,5.12,3.6,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion","transporter activity;other molecular function","TIMM8B","ENSG00000150779","","Mitochondrial protein import","",179.9,149.5,177.5,156.4,221.5,417.9,0.6369690877104801,-0.6507047351042609,0.29086733303029855,0.5363050511191129,0.5401294047557043,0.26750217899444384,3936]
["Q9Y5K5-1","Ubiquitin carboxyl-terminal hydrolase isozyme L5 [OS=Homo sapiens]",61,15,80,1,329,37.6,5.33,271.77,"protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity;other molecular function","UCHL5","ENSCANG00000036448; ENSCATG00000035323; ENSG00000116750; ENSGGOG00000004347; ENSMFAG00000038349; ENSMLEG00000030039; ENSMNEG00000039813; ENSPPAG00000029294; ENSPTRG00000001793","","UCH proteinases; Downregulation of TGF-beta receptor signaling","TGF-beta signaling pathway",181.1,190,172.9,204.5,189.6,173.9,0.9577464788732395,-0.06228427825434257,0.4734855355975751,0.32469328362186295,0.649409979298682,0.18748104197880178,5329]
["Q9Y5K5-3","Isoform 3 of Ubiquitin carboxyl-terminal hydrolase isozyme L5 [OS=Homo sapiens]",61,15,82,1,328,37.5,5.4,278.15,"","","","UCHL5","","","","",8579.6,9108.4,8956.2,8897.7,8331.1,9127.4,1.010927220160721,0.01567913681291313,0.7523956189438564,0.12355374192820776,0.8413799845258028,0.07500782356859385,6536]
["Q9Y5K6","CD2-associated protein [OS=Homo sapiens]",41,23,57,23,639,71.4,6.4,150.5,"cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","CD2AP","ENSG00000198087","Bacterial invasion of epithelial cells","Nephrin family interactions","Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome; Genes controlling nephrogenesis",7314,6819.1,7061,7636.1,8096.1,4549.7,1.0449760624004654,0.06346989440980919,0.7998920193643166,0.09696863620728897,0.8728591772967738,0.059055817527164045,6698]
["Q9Y5K8","V-type proton ATPase subunit D [OS=Homo sapiens]",39,11,36,11,247,28.2,9.36,101.86,"cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;cytosol","transporter activity","ATP6V1D","ENSG00000100554","Oxidative phosphorylation; Metabolic pathways; Phagosome; mTOR signaling pathway; Synaptic vesicle cycle; Collecting duct acid secretion; Vibrio cholerae infection; Epithelial cell signaling in Helicobacter pylori infection; Human papillomavirus infection; Rheumatoid arthritis","Neutrophil degranulation; Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport","Proximal tubule transport",4118.7,3882.3,3708.3,3850.9,3964.1,3413.4,1.042828898151117,0.0605024675043682,0.47946286734045973,0.3192450217229118,0.6536829131489311,0.18463286706424556,5361]
["Q9Y5L0-2","transportin-3 [OS=Homo sapiens]",31,23,71,23,923,104.1,5.57,225.81,"transport","other membranes;nucleus;other cell component","other molecular function","TNPO3","ENSCANG00000033070; ENSCATG00000030018; ENSG00000064419; ENSGGOG00000008339; ENSMLEG00000037881; ENSMMUG00000004311; ENSMNEG00000045277; ENSPPAG00000034975; ENSPPYG00000017990; ENSPTRG00000019676","Nucleocytoplasmic transport","","",7105.9,7025,7117,7307.7,7200.5,6476.4,1.0125472965889273,0.017989298575668815,0.7550712928664632,0.12201204090490823,0.8426959962682822,0.07432906944973688,6549]
["Q9Y5M8","signal recognition particle receptor subunit beta [OS=Homo sapiens]",50,11,82,11,271,29.7,9.04,282.32,"transport","other membranes;cytoskeleton;ER/Golgi;other cell component","other molecular function","SRPRB","ENSG00000144867","Protein export","XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane","",9588.3,9423.8,9170.1,8627.2,9191.7,9045.2,1.0490654814417752,0.06910473206476331,0.10259692923178333,0.9888656376418377,0.34256781898360184,0.4652534373257964,2189]
["Q9Y5N5","HemK methyltransferase family member 2 [OS=Homo sapiens]",24,5,9,5,214,22.9,5.11,21.42,"protein metabolism;DNA metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","N6AMT1","ENSG00000156239","","Eukaryotic Translation Termination; Methylation","",730.8,725,772.4,792.9,870.4,1349,0.7397005610330976,-0.43498672487525014,0.2086139330839114,0.6806566889134074,0.4672875381275846,0.33041580081730926,3263]
["Q9Y5N6","Origin recognition complex subunit 6 [OS=Homo sapiens]",7,1,1,1,252,28.1,8.66,2.55,"DNA metabolism;other metabolic processes;other biological processes","nucleus;other cell component","nucleic acid binding activity","ORC6","ENSG00000091651","Cell cycle","Assembly of the ORC complex at the origin of replication; CDT1 association with the CDC6:ORC:origin complex; Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; CDC6 association with the ORC:origin complex; E2F-enabled inhibition of pre-replication complex formation","Cell cycle; G1 to S cell cycle control; DNA replication",77.3,72.1,60.7,95.5,93.2,97.6,0.7338456164862032,-0.4464515083263072,0.007408030356371345,2.1302972466855237,0.10392570801289475,0.983277008101075,521]
["Q9Y5P4-1","Collagen type IV alpha-3-binding protein [OS=Homo sapiens]",24,14,34,14,624,70.8,5.48,79.24,"cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes","other membranes;cytosol;mitochondrion;ER/Golgi;nucleus","transporter activity;kinase activity;other molecular function","CERT1","ENSG00000113163; ENSPTRG00000016996","","","Sphingolipid pathway",3353.4,3464.7,3338,3195.8,3106.1,2711.5,1.1267779084474228,0.17220318369433027,0.06871688871614753,1.1629365122151964,0.28553254100416275,0.5443443897886848,1759]
["Q9Y5P6","Mannose-1-phosphate guanyltransferase beta [OS=Homo sapiens]",45,11,38,11,360,39.8,6.61,132.58,"other metabolic processes","other cell component","other molecular function","GMPPB","ENSG00000173540","Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism; Metabolic pathways; Biosynthesis of cofactors; Biosynthesis of nucleotide sugars","Synthesis of GDP-mannose","",4021.9,4210.7,4129.6,4114.9,3863.4,3937.3,1.03748027795495,0.05308391172025948,0.18289333023127352,0.7378021321210154,0.4407409662579552,0.35581658054770593,3033]
["Q9Y5Q8-1","general transcription factor 3C polypeptide 5 [OS=Homo sapiens]",23,10,18,10,519,59.5,6.9,39.12,"RNA metabolism OR transcription;other metabolic processes;developmental processes","nucleus;other cell component","nucleic acid binding activity","GTF3C5","ENSG00000148308","","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter","",1249.6,1289.6,1374.4,1287.4,1269,1408.4,0.9870863599677158,-0.018751783613215098,0.7800720413831179,0.10786528739876024,0.8599617723181311,0.06552085391956039,6630]
["Q9Y5Q9","General transcription factor 3C polypeptide 3 [OS=Homo sapiens]",23,14,28,14,886,101.2,5.07,89.01,"RNA metabolism OR transcription;other metabolic processes","other membranes;nucleus;other cell component","nucleic acid binding activity","GTF3C3","ENSG00000119041","","RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter","",1449.5,1602.8,1582.3,1570.2,1521.3,1454.1,1.0195793734600493,0.02797409241164778,0.6396510621163729,0.19405687464716323,0.7674342765936588,0.11495880742719526,6092]
["Q9Y5R8","trafficking protein particle complex subunit 1 [OS=Homo sapiens]",4,1,1,1,145,16.8,9.16,1.79,"transport","non-structural extracellular;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component","","TRAPPC1","ENSG00000170043","","Neutrophil degranulation; COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs","",68.4,68.9,85.6,68.9,89.6,53.9,1.0494350282485876,0.06961285045559881,0.781386371506996,0.1071341677604844,0.8602429566718833,0.06537887452343183,6639]
["Q9Y5S1","Transient receptor potential cation channel subfamily V member 2 [OS=Homo sapiens]",17,7,12,7,764,85.9,5.83,30.85,"cell organization and biogenesis;stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;other cell component","transporter activity","TRPV2","ENSG00000187688","NOD-like receptor signaling pathway; Inflammatory mediator regulation of TRP channels","TRP channels","",1010.2,1011.8,981,936.5,977.1,2221.9,0.726151614073268,-0.46165729317419724,0.42157143334839936,0.3751288255931573,0.6184796480014956,0.20867458690967203,4982]
["Q9Y5S2","Serine/threonine-protein kinase MRCK beta [OS=Homo sapiens]",3,4,5,4,1711,194.2,6.37,8.61,"cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","kinase activity;other molecular function","CDC42BPB","ENSG00000198752","","CDC42 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle","VEGFA-VEGFR2 signaling pathway",911,1284.1,1487.2,769.1,636.6,212.7,2.2752718734552646,1.186038944014987,0.04451607229795264,1.351483160927062,0.23108520768873284,0.6362278538491827,1408]
["Q9Y5S9","RNA-binding protein 8A [OS=Homo sapiens]",47,7,39,1,174,19.9,5.72,112.15,"RNA metabolism OR transcription;other metabolic processes;transport;other biological processes","cytosol;nucleus;other cell component","nucleic acid binding activity","RBM8A","ENSG00000265241","Nucleocytoplasmic transport; mRNA surveillance pathway; Spliceosome","Regulation of expression of SLITs and ROBOs; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); RNA Polymerase II Transcription Termination; mRNA 3'-end processing; Transport of Mature mRNA derived from an Intron-Containing Transcript","",1559.2,1370.3,1185.4,1846.1,1465,3052.4,0.6466409994499882,-0.628963112279563,0.20117617010770103,0.6964234639921102,0.4599301305339965,0.3373081383798252,3197]
["Q9Y5S9-2","Isoform 2 of RNA-binding protein 8A [OS=Homo sapiens]",47,7,32,1,173,19.7,5.92,94.61,"","","","RBM8A","","","","",2928.1,2564,2327.7,3466.6,2847,2293.7,0.9085078944616779,-0.13842904410300758,0.5288490552154927,0.27666826717354215,0.6870525674671235,0.16301003311875129,5626]
["Q9Y5T5-2","Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 16 [OS=Homo sapiens]",23,13,22,13,822,93.4,6.93,70.14,"","","","USP16","","","","",1587.8,1610.7,1625.6,1776.4,1733.1,2003,0.8751201814058958,-0.19244693712851632,0.05306610368456428,1.2751827987548985,0.2508797877299355,0.6005343264532316,1546]
["Q9Y5U2-1","Protein TSSC4 [OS=Homo sapiens]",13,4,9,4,329,34.3,5.19,23.79,"","","","TSSC4","ENSG00000184281","","","",807.7,773.4,730.6,775.7,803,1294,0.8047133358861002,-0.313453153336978,0.33276148494841645,0.47786694633068544,0.5729455108334455,0.24188667902668393,4245]
["Q9Y5U8","Mitochondrial pyruvate carrier 1 [OS=Homo sapiens]",27,2,4,2,109,12.3,9.61,11.35,"transport","other membranes;mitochondrion","transporter activity","MPC1","ENSG00000060762","Diabetic cardiomyopathy","Pyruvate metabolism","Glycolysis and gluconeogenesis",327.4,534.8,580.6,385.6,313,619.3,1.0947719857348812,0.1306304229736525,0.7478375091240985,0.12619275582116393,0.8382064643747947,0.07664899414465051,6521]
["Q9Y5U9","immediate early response 3-interacting protein 1 [OS=Homo sapiens]",24,1,9,1,82,9,8.22,48,"transport;developmental processes;other biological processes","other membranes;ER/Golgi;other cell component","","IER3IP1","ENSG00000134049","","","",1034.6,863.6,1035.8,762.7,929.2,355.5,{"$f":"AVERAGE(S7234:U7234)/AVERAGE(V7234:X7234)","v":1.4330370225652045},{"$f":"LOG(Y7234,2)","v":0.5190758821619997},{"$f":"TTEST(V7234:X7234,S7234:U7234,2,2)","v":0.17548749779234887},0.7557538184186761,{"$f":"AA7234*7309/AE7234","v":0.43288495489850753},0.3636275080147542,2963]
["Q9Y5W8","Sorting nexin-13 [OS=Homo sapiens]",4,3,3,3,968,112.1,6.58,8.65,"transport;other biological processes","other membranes;other cytoplasmic organelle","other molecular function","SNX13","ENSG00000071189","","","",156.9,160.4,157.7,170.2,173.9,246.2,0.8046755886837202,-0.31352082834189393,0.1955924943389191,{"$f":"-LOG10(AA7235)","v":0.7086478148333502},0.453836679721638,{"$f":"-LOG10(AC7235)","v":0.34310040673897774},3150]
["Q9Y5W9","Sorting nexin-11 [OS=Homo sapiens]",5,1,1,1,270,30.4,7.05,3.13,"cell organization and biogenesis;transport","other membranes;other cytoplasmic organelle","other molecular function","SNX11","ENSG00000002919","","","",79.5,73.2,64.2,62.3,59.7,130.6,0.8586698337292161,-0.21982458611527833,0.6410535519928526,0.19310568910281395,0.7682342042163895,0.11450636057654204,6099]
["Q9Y5X2","Sorting nexin-8 [OS=Homo sapiens]",15,6,8,6,465,52.5,7.39,23.67,"transport","other membranes;cytosol;other cytoplasmic organelle;other cell component","other molecular function","SNX8","ENSG00000106266","","","",650.4,668.3,627.9,600.9,604.8,1394.9,0.7485195724063678,-0.417888054295816,0.4557845657018274,0.3412403854830236,0.6385526913388263,0.19480326032142548,5217]
["Q9Y5X3","sorting nexin-5 [OS=Homo sapiens]",45,16,60,15,404,46.8,6.76,184.77,"protein metabolism;other metabolic processes;transport;other biological processes","plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;cytoskeletal activity;other molecular function","SNX5","ENSG00000089006","Endocytosis","Golgi Associated Vesicle Biogenesis","",8099.3,8200.3,7877.4,8027.7,7461.4,3522,1.2717307257339134,0.34679322897638726,0.2920364691972926,0.5345629109414339,0.5407890938340542,0.2669720754529763,3947]
["Q9Y5Y0","Feline leukemia virus subgroup C receptor-related protein 1 [OS=Homo sapiens]",2,1,1,1,555,59.8,5.97,3.04,"other metabolic processes;transport;developmental processes;other biological processes","plasma membrane;other membranes;mitochondrion","transporter activity;other molecular function","FLVCR1","ENSG00000162769","","","",186.8,172.4,178.8,199.4,222.3,293.4,0.7523423297440918,-0.4105388305304604,0.10798917431762144,0.9666197794183402,0.34847367553531794,0.4578300238832179,2265]
["Q9Y5Y2","Cytosolic Fe-S cluster assembly factor NUBP2 [OS=Homo sapiens]",42,8,17,8,271,28.8,5.83,54.52,"cell organization and biogenesis;other metabolic processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","NUBP2","ENSG00000095906","","Cytosolic iron-sulfur cluster assembly","",2033,1923.9,2045.2,1820.8,1755.8,2313.3,1.0190495594152702,0.0272242157667335,0.8457022680303873,0.07278250470285703,0.9022387793072691,0.04467851033826743,6851]
["Q9Y5Y5","Peroxisomal membrane protein PEX16 [OS=Homo sapiens]",15,3,8,3,336,38.6,9.85,31.89,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","other molecular function","PEX16","ENSG00000121680","Peroxisome","Class I peroxisomal membrane protein import","",548.5,729,576.8,905.4,593.5,1253.7,0.6736539998546828,-0.5699203059485444,0.20638248671319842,0.6853271590144098,0.4649967926592994,0.33255004266955523,3244]
["Q9Y5Y6","suppressor of tumorigenicity 14 protein [OS=Homo sapiens]",20,16,31,16,855,94.7,6.55,89.97,"protein metabolism;developmental processes","non-structural extracellular;plasma membrane;other membranes","other molecular function","ST14","ENSG00000149418","MicroRNAs in cancer","Formation of the cornified envelope","",3155.1,2989.7,2985.9,3261.2,3742.2,4199.6,0.8150227617602426,-0.2950877437398805,0.0669582582792039,1.17419585175268,0.2807790646946078,0.5516352769787002,1743]
["Q9Y5Z7","host cell factor 2 [OS=Homo sapiens]",11,7,15,6,792,86.7,8.48,42.05,"cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","other molecular function","HCFC2","ENSG00000111727","Herpes simplex virus 1 infection","","",894.1,959,928.2,1041.4,1061.4,1913.2,0.692554780876494,-0.5299999024647951,0.22611078815194005,0.6456787161903093,0.48664421395834206,0.31278843587825145,3396]
["Q9Y5Z9-1","UbiA prenyltransferase domain-containing protein 1 [OS=Homo sapiens]",8,2,3,2,338,36.8,8.15,6.32,"other metabolic processes;other biological processes","other membranes;mitochondrion;ER/Golgi;nucleus;other cell component","other molecular function","UBIAD1","ENSG00000120942; ENSGGOG00000001270","","Metabolism of vitamin K","7q11.23 copy number variation syndrome",114.8,103.4,98.2,118.8,131.8,200.7,0.7010857522712164,-0.5123371787396958,0.15730168899104358,0.803266614213635,0.41341893018178266,0.3836096411938215,2781]
["Q9Y606","tRNA pseudouridine synthase A [OS=Homo sapiens]",36,15,26,15,427,47.4,8.41,75.22,"RNA metabolism OR transcription;other metabolic processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","PUS1","ENSG00000177192","","","",2318.5,2297.9,2322.5,2236.3,2178.9,2185.3,1.0512688432694492,0.07213166002643628,0.00460121783230896,2.337127205741864,0.08283325403040934,1.0817952774350854,406]
["Q9Y608","Leucine-rich repeat flightless-interacting protein 2 [OS=Homo sapiens]",5,3,11,2,721,82.1,6.95,36.04,"cell-cell signaling;signal transduction;other biological processes","","other molecular function","LRRFIP2","ENSG00000093167","","","VEGFA-VEGFR2 signaling pathway; Genotoxicity pathway",351.5,312.1,481.4,429.2,512.2,243.6,0.9662447257383967,-0.049539460801315056,0.8945600969811995,0.048390478002593454,0.9315201237833862,0.03080775853083364,7019]
["Q9Y613","FH1/FH2 domain-containing protein 1 [OS=Homo sapiens]",38,33,92,33,1164,126.5,6.39,245.41,"cell organization and biogenesis;transport;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","cytoskeletal activity;other molecular function","FHOD1","ENSG00000135723","Salmonella infection","","VEGFA-VEGFR2 signaling pathway",6184.8,6335.1,6080.6,6514.9,6516.3,8005.6,0.8841886598722238,-0.1775738637066925,0.1811194015240565,0.7420350255361536,0.43907187586710744,0.35746438012835074,3015]
["Q9Y617-1","phosphoserine aminotransferase [OS=Homo sapiens]",65,21,89,20,370,40.4,7.66,269.38,"other metabolic processes","cytosol;other cell component","other molecular function","PSAT1","ENSG00000135069; ENSGGOG00000015480; ENSPPAG00000036829; ENSPTRG00000021045","Glycine, serine and threonine metabolism; Cysteine and methionine metabolism; Vitamin B6 metabolism; Metabolic pathways; Carbon metabolism; Biosynthesis of amino acids; Biosynthesis of cofactors","Serine biosynthesis","Trans-sulfuration and one-carbon metabolism; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Male infertility; Neuroinflammation and glutamatergic signaling",11366.7,11704.7,11992.9,15848.9,15281.6,15400.3,0.7535718276926251,-0.40818306412969996,1.0705244389972211E-4,3.970403413749753,0.02006272596059151,1.6976100588922791,39]
["Q9Y619","mitochondrial ornithine transporter 1 [OS=Homo sapiens]",5,2,2,2,301,32.7,9.13,2.12,"other metabolic processes;transport","other membranes;mitochondrion","transporter activity","SLC25A15","ENSG00000102743","","Urea cycle","",58.6,67.1,72.8,55,55.8,200.5,0.6376485705107614,-0.6491665694388593,0.48182977701244967,0.3171063641704098,0.654955149745954,0.18378843876355602,5377]
["Q9Y624","Junctional adhesion molecule A [OS=Homo sapiens]",51,12,52,12,299,32.6,7.9,148.06,"cell adhesion;cell organization and biogenesis;stress response;transport;other biological processes","plasma membrane;other membranes;other cell component","signal transduction activity or receptor binding;other molecular function","F11R","ENSG00000158769","Cell adhesion molecules; Tight junction; Leukocyte transendothelial migration; Epithelial cell signaling in Helicobacter pylori infection","Integrin cell surface interactions; Cell surface interactions at the vascular wall; Tight junction interactions; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)","1q21.1 copy number variation syndrome",7298.9,7230.2,6925.7,5188.2,5535.4,5637.2,1.3113539680211237,0.3910571584668626,6.719298975183894E-4,3.1726760345489224,0.036111291330602265,1.442356981035167,136]
["Q9Y639-1","Isoform 1 of Neuroplastin [OS=Homo sapiens]",11,3,5,3,282,31.3,6.87,17.58,"","","","NPTN","","","","",936.4,900.3,909.2,973.3,1006.2,1224.5,0.8570224719101122,-0.2225950612751042,0.12740373589779447,0.8948178368671627,0.3759361750815421,0.4248858815690267,2477]
["Q9Y657","Spindlin-1 [OS=Homo sapiens]",37,7,7,5,262,29.6,6.96,20.32,"cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;signal transduction;other biological processes","other membranes;cytosol;nucleus","other molecular function","SPIN1","ENSG00000106723","","","",358.4,370.9,364.5,406.6,441.5,824.5,0.6539519311251942,-0.6127435008704072,0.22308902680281478,0.6515217910616955,0.4835580358546184,0.3155513951304273,3372]
["Q9Y666","Solute carrier family 12 member 7 [OS=Homo sapiens]",8,8,13,7,1083,119,6.71,26.59,"cell-cell signaling;cell organization and biogenesis;transport;other biological processes","plasma membrane;other membranes;other cell component","transporter activity;other molecular function","SLC12A7","ENSG00000113504","Collecting duct acid secretion","Cation-coupled Chloride cotransporters","",579.3,553,552.6,513.3,557.1,880.5,0.8636526731252242,-0.2114768606293123,0.4877027221681489,0.3118448203376801,0.6592600695999631,0.18094322802933177,5407]
["Q9Y672","Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase [OS=Homo sapiens]",10,5,17,5,507,58.1,8.46,38.32,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","other molecular function","ALG6","ENSG00000088035","N-Glycan biosynthesis; Metabolic pathways","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG6 causes CDG-1c","GPCRs, other",1982.3,1891.2,2006.8,1533.1,1630.4,1181.4,1.3533798246219708,0.43656678698449786,0.02208107320186133,1.6559798225044497,0.1691724989857489,0.7716702353245719,954]
["Q9Y673","dolichyl-phosphate beta-glucosyltransferase [OS=Homo sapiens]",37,13,32,13,324,36.9,9.28,77.45,"protein metabolism;other metabolic processes;developmental processes","other membranes;ER/Golgi","other molecular function","ALG5","ENSG00000120697","N-Glycan biosynthesis; Metabolic pathways","Synthesis of dolichyl-phosphate-glucose","",3246.6,3426.1,3476.4,2769.5,2689.6,1998.1,1.3609799924904789,0.4446458582108032,0.024367237946056265,1.6131936957955297,0.17703791465976665,0.7519337146314654,1006]
["Q9Y676","28S ribosomal protein S18b, mitochondrial [OS=Homo sapiens]",17,3,6,3,258,29.4,9.38,16.02,"protein metabolism;other metabolic processes","other membranes;mitochondrion;translational apparatus;nucleus;other cell component","other molecular function","MRPS18B","ENSG00000203624; ENSG00000204568; ENSG00000223775; ENSG00000226111; ENSG00000227420; ENSG00000229861; ENSG00000233813","Viral carcinogenesis","Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination","",222.2,206.4,218.6,191.5,178.6,205.2,1.124978272205806,0.1698971375457393,0.05702468058602599,1.243937138670601,0.25984625336861844,0.585283540734773,1604]
["Q9Y678","Coatomer subunit gamma-1 [OS=Homo sapiens]",67,46,229,42,874,97.7,5.47,675.39,"transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","COPG1","ENSG00000181789","","COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport","VEGFA-VEGFR2 signaling pathway",22335.9,23070.4,23015.4,22028.2,21004.3,20110,1.0836077127133075,0.11584256725134792,0.043190760902411446,1.3646091448108557,0.2276000515037673,0.6428276440001677,1387]
["Q9Y679-1","Ancient ubiquitous protein 1 [OS=Homo sapiens]",13,6,16,6,476,53,8.09,46.26,"","","","","","","","",1691.2,1603.3,1656.1,1504.1,1496.8,2531.5,0.8948376834646808,-0.16030208234049206,0.6036707877094455,0.21919983962366663,0.7409285956957745,0.13022364355848998,5955]
["Q9Y689-1","ADP-ribosylation factor-like protein 5A [OS=Homo sapiens]",4,1,1,1,179,20.7,6.79,2.51,"transport;other biological processes","ER/Golgi","other molecular function","ARL5A; LOC111161526","ENSAMEG00000008735; ENSANAG00000027698; ENSCANG00000029546; ENSCATG00000029667; ENSCCAG00000023321; ENSCJAG00000040846; ENSECAG00000023672; ENSFCAG00000014742; ENSG00000162980; ENSGGOG00000002066; ENSLCNG00005010847; ENSMMUG00000010521; ENSMNEG00000035230; ENSMPUG00000000396; ENSNVIG00000004853; ENSOCUG00000035346; ENSOGAG00000011424; ENSPANG00000009772; ENSPPAG00000033494; ENSPTRG00000012538; ENSRBIG00000031831; ENSRFEG00010001991; ENSRROG00000040290; ENSSBOG00000034323; ENSSSCG00000031541; ENSSSCG00070004184; ENSSSUG00005001466","","","",44.6,57,47.6,40.5,34.5,84.8,0.9336670838548183,-0.0990198726727393,0.8389505212076305,0.07626365180556034,0.8984453274002302,0.046508345634381026,6825]
["Q9Y692-1","Glucocorticoid modulatory element-binding protein 1 [OS=Homo sapiens]",8,4,8,4,573,62.6,4.83,26.33,"other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","GMEB1","ENSG00000162419; ENSGGOG00000009221; ENSPPAG00000038756","","","",329,310.6,281,328.5,354.8,419.1,0.8350870827285921,-0.2600014454804051,0.11633822861528292,0.9342775531254512,0.3633829542517534,0.43963544865162113,2340]
["Q9Y696","Chloride intracellular channel protein 4 [OS=Homo sapiens]",74,15,147,13,253,28.8,5.59,511.58,"transport;developmental processes;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component","transporter activity","CLIC4","ENSG00000169504","","","",12850.3,13341.1,14017.4,13157.6,13710.3,10461.1,1.0771464544991831,0.10721441962682063,0.41604314754923977,0.38086162665494516,0.6171827411076504,0.20958622704588134,4927]
["Q9Y697","Cysteine desulfurase, mitochondrial [OS=Homo sapiens]",48,15,40,15,457,50.2,8.31,118.05,"cell organization and biogenesis;protein metabolism;other metabolic processes","cytosol;mitochondrion;nucleus","other molecular function","NFS1","ENSG00000244005","Thiamine metabolism; Metabolic pathways; Biosynthesis of cofactors; Sulfur relay system","","",3154.1,3255.3,3090,2905,2766.2,3445.4,1.0419893381304433,0.05934051571140103,0.5808849519348043,0.235909873956422,0.7237790851843648,0.1403939707169824,5866]
["Q9Y6A4","Cilia- and flagella-associated protein 20 [OS=Homo sapiens]",38,7,19,7,193,22.8,9.76,47.39,"cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes","cytoskeleton;nucleus;other cell component","","CFAP20","ENSG00000070761","","","",2097.1,2506.2,2487.7,2314.3,1875.6,1614.5,1.2216594307766522,0.2888421525790858,0.15348703671539823,0.8139282984976021,0.4095789526662453,0.3876623688675904,2739]
["Q9Y6A5","Transforming acidic coiled-coil-containing protein 3 [OS=Homo sapiens]",32,22,51,22,838,90.3,5.05,162.76,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes","cytosol;cytoskeleton;other cell component","","TACC3","ENSG00000013810","","Negative regulation of NOTCH4 signaling; NOTCH3 Activation and Transmission of Signal to the Nucleus","",4081,4104.1,4252.1,4256.7,4354.1,6058.6,0.8478329038679155,-0.23814813731021783,0.2740824989920897,0.5621186946094201,0.5277315556199114,0.2775869364807022,3796]
["Q9Y6A9","Signal peptidase complex subunit 1 [OS=Homo sapiens]",17,2,7,2,102,11.8,9.31,25.02,"protein metabolism;other metabolic processes","other membranes;ER/Golgi","translation activity;other molecular function","SPCS1","ENSG00000114902","Protein export","","",1131.7,1057.9,1038.3,926.9,1087.6,853.2,1.1256058862503053,0.17070177814507967,0.18380118439389467,0.7356516943967216,0.441473170139657,0.3550956848709158,3043]
["Q9Y6B6","GTP-binding protein SAR1b [OS=Homo sapiens]",47,8,65,4,198,22.4,6.11,172.63,"cell organization and biogenesis;transport;other biological processes","other membranes;cytosol;ER/Golgi","other molecular function","SAR1B","ENSG00000152700","Protein processing in endoplasmic reticulum; Legionellosis","MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Chylomicron assembly","Sterol regulatory element-binding proteins (SREBP) signaling",2150.7,2126,2043.4,1919.2,1980,1847.4,1.0997981415097624,0.13723875378022796,0.018984792014846385,1.7215941563487462,0.15822103174060687,0.8007357878308137,877]
["Q9Y6B7","AP-4 complex subunit beta-1 [OS=Homo sapiens]",5,5,8,5,739,83.2,5.86,15.67,"transport;other biological processes","other membranes;cytosol;ER/Golgi;other cytoplasmic organelle","other molecular function","AP4B1","ENSG00000134262","Lysosome","Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis","",508.9,513.5,513.4,516,580.7,489.9,0.9679818479768058,-0.04694810118851094,0.5650172075670408,0.2479383255653147,0.7125104848356627,0.1472087404804787,5796]
["Q9Y6C2","EMILIN-1 [OS=Homo sapiens]",4,3,3,3,1016,106.6,5.15,9.3,"","","","","","","","",312.5,332.5,310.1,477.6,481,684.7,0.5812085437838495,-0.7828721840983137,0.029042703205381798,1.5369629632975805,0.19020888685316806,0.7207691960151674,1116]
["Q9Y6C9","Mitochondrial carrier homolog 2 [OS=Homo sapiens]",45,12,36,12,303,33.3,7.97,143.4,"other biological processes","other membranes;mitochondrion","","MTCH2","ENSG00000109919; ENSG00000285121","","","",4787.1,5438.2,4863.4,5305.7,4488.1,6752.8,0.9118912646706877,-0.13306628943684334,0.5219594560393045,0.2823632301438127,0.6828354509023227,0.16568393962000416,5587]
["Q9Y6D0","selenoprotein K [OS=Homo sapiens]",10,1,2,1,94,10.6,10.86,4.11,"protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi","other molecular function","SELENOK","ENSG00000113811","","","Selenium micronutrient network",84,83.9,130.3,154.8,207.7,57.5,0.7100000000000002,-0.49410907027004225,0.43297537867428154,0.36353679928155186,0.6244311449744128,0.2045154436089826,5068]
["Q9Y6D5","Brefeldin A-inhibited guanine nucleotide-exchange protein 2 [OS=Homo sapiens]",29,43,115,33,1785,201.9,6.33,337.73,"cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes","other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component","signal transduction activity or receptor binding;enzyme regulator activity;other molecular function","ARFGEF2","ENSG00000124198","Endocytosis","Association of TriC/CCT with target proteins during biosynthesis","",9676.5,9959.4,9967.4,9717.7,9331.1,9292.4,1.044532341608683,0.06285716292307456,0.06446297085838341,1.1906896833463172,0.27440876762022387,0.5616020166232607,1717]
["Q9Y6D6","Brefeldin A-inhibited guanine nucleotide-exchange protein 1 [OS=Homo sapiens]",21,30,54,20,1849,208.6,5.85,148.05,"cell organization and biogenesis;transport;developmental processes;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","enzyme regulator activity;cytoskeletal activity;other molecular function","ARFGEF1","ENSG00000066777","Endocytosis","","",2161.4,2117,2055,2356.2,2376,1933.4,0.9501620259241478,-0.07375454558510706,0.4948578228492867,0.305519559897461,0.6649964749412459,0.1771806568286591,5439]
["Q9Y6D9","mitotic spindle assembly checkpoint protein MAD1 [OS=Homo sapiens]",30,21,46,21,718,83,5.92,141.24,"cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","other molecular function","MAD1L1","ENSG00000002822","Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation; Human T-cell leukemia virus 1 infection; Viral carcinogenesis","Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal","Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; Malignant pleural mesothelioma; CCL18 signaling pathway",5036.4,4978.6,4958.6,5338.1,5330,5061.8,0.9519195926229664,-0.07108837873154082,0.05467680763883987,1.262196850090119,0.25421933017320647,0.5947914299095352,1572]
["Q9Y6E0","Serine/threonine-protein kinase 24 [OS=Homo sapiens]",44,16,82,9,443,49.3,5.69,238.94,"protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes","other membranes;cytosol;ER/Golgi;nucleus;other cell component","kinase activity;other molecular function","STK24","ENSG00000102572","","Apoptotic cleavage of cellular proteins","",3831.2,4046.8,3872.8,4121.6,3869.7,5162.4,0.8933455985768262,-0.16270969233159036,0.3084717019358736,0.5107846703885583,0.5573843434979728,0.25384523445287654,4045]
["Q9Y6E2","Basic leucine zipper and W2 domain-containing protein 2 [OS=Homo sapiens]",43,20,98,16,419,48.1,6.68,245.56,"developmental processes;other biological processes","other cell component","","BZW2","ENSG00000136261","","","",7988,8131.2,7853.6,7724.9,7336.2,6070.7,1.1344419311180307,0.1819827634111926,0.13446255928598333,0.8713986268816639,0.3861637901065824,0.4132284516704684,2545]
["Q9Y6G1","Transmembrane protein 14A [OS=Homo sapiens]",6,1,1,1,99,10.7,10.55,0,"cell organization and biogenesis;transport;other biological processes","other membranes;mitochondrion;ER/Golgi","","TMEM14A","ENSG00000096092","","","",21.6,52,101.9,46.5,23.5,35.4,1.6650853889943074,0.7355961635547085,0.39125820964987895,0.4075365366832341,0.6021701946369689,0.22028074438127948,4749]
["Q9Y6G5","COMM domain-containing protein 10 [OS=Homo sapiens]",29,4,8,4,202,23,6.54,19.29,"","nucleus;other cell component","","COMMD10","ENSG00000145781","","Neddylation","",295.9,306.4,274.6,284.1,293,230.9,1.0852722772277228,0.11805703688805184,0.34613032314007214,0.4607603521778737,0.5797127708136542,0.23678713221020503,4364]
["Q9Y6G9","Cytoplasmic dynein 1 light intermediate chain 1 [OS=Homo sapiens]",54,23,68,23,523,56.5,6.42,245.49,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cell component","other molecular function","DYNC1LI1","ENSG00000144635","Phagosome; Vasopressin-regulated water reabsorption; Salmonella infection","Neutrophil degranulation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal; MHC class II antigen presentation; COPI-mediated anterograde transport; HCMV Early Events; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy","Ciliary landscape; Intraflagellar transport proteins binding to dynein",9487.9,8915.9,8923.9,8953,9569,7860.4,1.0358307053186973,0.050788230287745706,0.5870403514012512,0.23133204562018875,0.7294590153675187,0.13699910390726636,5882]
["Q9Y6H1","Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 [OS=Homo sapiens]",15,2,2,2,151,15.5,9.22,5.96,"cell organization and biogenesis;stress response;other biological processes","mitochondrion;nucleus","nucleic acid binding activity;other molecular function","CHCHD2","ENSG00000106153","","Mitochondrial protein import","",181.2,173.6,199.6,306.1,312.3,373.5,0.5589273112208891,-0.8392674228384092,3.0931221254626323E-3,2.50960293244834,0.0691364820030776,1.1602927232246532,327]
["Q9Y6H3","Mitochondrial inner membrane protease ATP23 homolog [OS=Homo sapiens]",14,2,2,2,246,28.1,8.03,7.23,"cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response","plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component","kinase activity;other molecular function","ATP23","ENSG00000166896; ENSG00000262145","","","",44.6,57.9,60.6,55.8,46.9,68.5,0.9526869158878506,-0.06992591968926241,0.7522185433276083,0.12365596476420065,0.8413106860262416,0.07504359479679082,6535]
["Q9Y6I3","epsin-1 [OS=Homo sapiens]",20,10,24,9,576,60.3,4.83,78.69,"transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component","other molecular function","EPN1","ENSG00000063245","Endocytosis","Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation","VEGFA-VEGFR2 signaling pathway; EGF/EGFR signaling pathway",2804.7,2808,2786.4,2795.7,2836.8,2571.1,1.0238310010239409,0.03397759609359308,0.4755032966363129,0.3228464677780992,0.6502251814994969,0.1869362154389231,5345]
["Q9Y6I4-1","Ubiquitin carboxyl-terminal hydrolase 3 [OS=Homo sapiens]",10,4,6,4,520,58.9,8.18,22.19,"cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","USP3","ENSG00000140455","","Ub-specific processing proteases","",447.5,475.6,487.3,496.4,427.7,1107.7,0.694162811300325,-0.526654017807425,0.3927821036346422,0.40584830823178636,0.6032453026824123,0.2195060511465709,4759]
["Q9Y6I9","Testis-expressed protein 264 [OS=Homo sapiens]",52,11,32,11,313,34.2,4.86,102.42,"cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response","non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component","other molecular function","TEX264","ENSG00000164081","","Platelet degranulation","",2736.1,2692,2644.6,2572,3068.2,3293,0.903673935431872,-0.14612578307927535,0.2523618392562235,0.5979763160420968,0.5106624261139916,0.29186609579959205,3612]
["Q9Y6J0","Calcineurin-binding protein cabin-1 [OS=Homo sapiens]",5,9,12,9,2220,246.2,6.02,36.69,"cell organization and biogenesis;signal transduction;other biological processes","cytosol;nucleus;other cell component","enzyme regulator activity","CABIN1","ENSG00000099991","","Formation of Senescence-Associated Heterochromatin Foci (SAHF)","",1183.9,1104.5,1150.3,1293.8,1297.2,1434.8,0.8541656316756917,-0.22741224421302558,0.019508312764721054,1.7097802902496517,0.16075113641188973,0.7938459481974052,887]
["Q9Y6J9","TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L [OS=Homo sapiens]",13,6,8,6,622,67.8,8.97,15.23,"cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","nucleic acid binding activity;other molecular function","TAF6L","ENSG00000162227","Basal transcription factors","HATs acetylate histones","",639.2,600.6,561.6,761.6,817,1088.5,0.6754152450226839,-0.5661533516236926,0.04935655762968926,1.3066551377625748,0.24227473453015366,0.615691873630778,1489]
["Q9Y6K0","Choline/ethanolaminephosphotransferase 1 [OS=Homo sapiens]",1,1,1,1,416,46.5,8.21,1.82,"other metabolic processes","other membranes;ER/Golgi;nucleus","other molecular function","CEPT1","ENSG00000134255","Phosphonate and phosphinate metabolism; Glycerophospholipid metabolism; Ether lipid metabolism; Metabolic pathways","Synthesis of PC; Synthesis of PE","Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways",83.5,83,77,73.6,76.1,84,1.041934103551562,0.059264038186879246,0.43468068457518794,0.36182965764395897,0.6250405515561772,0.20409180546268957,5083]
["Q9Y6K1","DNA (cytosine-5)-methyltransferase 3A [OS=Homo sapiens]",2,2,3,2,912,101.8,6.57,4.65,"cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","DNMT3A","ENSG00000119772","Cysteine and methionine metabolism; Metabolic pathways; MicroRNAs in cancer","PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; RMTs methylate histone arginines; SUMOylation of DNA methylation proteins","One-carbon metabolism; Trans-sulfuration and one-carbon metabolism; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; One-carbon metabolism and related pathways; MTHFR deficiency",85.2,196.3,87.8,144.3,93.2,2564.1,0.13181753283837808,-2.923385821227944,0.3767009197194568,0.4240033194606629,0.5942816797387243,0.22600765777984516,4633]
["Q9Y6K5","2'-5'-oligoadenylate synthase 3 [OS=Homo sapiens]",5,6,10,6,1087,121.1,8.4,24.05,"other metabolic processes;stress response;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;nucleus;other cell component","nucleic acid binding activity;other molecular function","OAS3","ENSG00000111331","NOD-like receptor signaling pathway; Hepatitis C; Measles; Influenza A; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Coronavirus disease","Interferon gamma signaling; Interferon alpha/beta signaling; OAS antiviral response","Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction",742.9,806,813.4,778.8,717.1,1416.2,0.8112015384087085,-0.3018677065346321,0.46027865480234087,0.33697916483338486,0.6405515399753064,0.1934459203668536,5252]
["Q9Y6K9","NF-kappa-B essential modulator [OS=Homo sapiens]",11,4,4,4,419,48.2,5.71,12.21,"cell organization and biogenesis;stress response;signal transduction;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","signal transduction activity or receptor binding;other molecular function","IKBKG","ENSG00000269335","Antifolate resistance; MAPK signaling pathway; Ras signaling pathway; Chemokine signaling pathway; NF-kappa B signaling pathway; PI3K-Akt signaling pathway; Apoptosis; Osteoclast differentiation; Toll-like receptor signaling pathway; NOD-like receptor signaling pathway; RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; C-type lectin receptor signaling pathway; IL-17 signaling pathway; Th1 and Th2 cell differentiation; Th17 cell differentiation; T cell receptor signaling pathway; B cell receptor signaling pathway; TNF signaling pathway; Adipocytokine signaling pathway; Alcoholic liver disease; Alzheimer disease; Epithelial cell signaling in Helicobacter pylori infection; Pathogenic Escherichia coli infection; Shigellosis; Salmonella infection; Yersinia infection; Chagas disease; Toxoplasmosis; Hepatitis C; Hepatitis B; Measles; Human cytomegalovirus infection; Influenza A; Human papillomavirus infection; Human T-cell leukemia virus 1 infection; Kaposi sarcoma-associated herpesvirus infection; Herpes simplex virus 1 infection; Epstein-Barr virus infection; Human immunodeficiency virus 1 infection; Coronavirus disease; Pathways in cancer; Viral carcinogenesis; Chemical carcinogenesis; Pancreatic cancer; Prostate cancer; Chronic myeloid leukemia; Acute myeloid leukemia; Small cell lung cancer; PD-L1 expression and PD-1 checkpoint pathway in cancer; Primary immunodeficiency; Lipid and atherosclerosis; Fluid shear stress and atherosclerosis","FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TAK1 activates NFkB by phosphorylation and activation of IKKs complex; TNFR1-induced NFkappaB signaling pathway; activated TAK1 mediates p38 MAPK activation; ER-Phagosome pathway; IKK complex recruitment mediated by RIP1; TICAM1, RIP1-mediated IKK complex recruitment; Regulation of TNFR1 signaling; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Ovarian tumor domain proteases; RIP-mediated NFkB activation via ZBP1; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; SUMOylation of immune response proteins","Nucleotide-binding oligomerization domain (NOD) pathway; Regulation of toll-like receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor (RLR) pathway; ATM signaling in development and disease ; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNAs involvement in the immune response in sepsis; Supression of HMGB1 mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Canonical NF-kB pathway; Cytosolic DNA-sensing pathway; Small cell lung cancer; Hepatitis B infection; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Network map of SARS-CoV-2 signaling pathway; T-cell receptor (TCR) signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway",301,288.1,508.3,501.9,591,540.5,0.671850128566181,-0.573788651896427,0.07809020753032368,1.1074034230008543,0.3042437776328016,0.5167782951599269,1876]
["Q9Y6M1","Insulin-like growth factor 2 mRNA-binding protein 2 [OS=Homo sapiens]",23,13,35,13,599,66.1,8.46,107.13,"transport;developmental processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","nucleic acid binding activity;other molecular function","IGF2BP2","ENSG00000073792","","Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA","",4094.7,4552.7,3985.7,4302.3,3808.4,3281.5,1.108925405101736,0.1491623219384698,0.2932171082122001,0.5328106936987407,0.5424256755056873,0.26565976149621395,3951]
["Q9Y6M5","zinc transporter 1 [OS=Homo sapiens]",45,15,58,15,507,55.3,6.48,185.42,"stress response;transport;developmental processes;other biological processes","plasma membrane;other membranes;ER/Golgi;nucleus;other cell component","transporter activity;other molecular function","SLC30A1","ENSG00000170385","Mineral absorption","Zinc efflux and compartmentalization by the SLC30 family","Zinc homeostasis",5896.2,5657.7,5704.6,4652.4,4872.3,6217.9,1.0962928614078995,0.1326332483546756,0.3648230437347326,0.4379177376386758,0.5896708594995933,0.22939033376404375,4522]
["Q9Y6M7-7","Isoform 7 of Sodium bicarbonate cotransporter 3 [OS=Homo sapiens]",7,8,12,8,1259,140.7,6.62,35,"","","","SLC4A7","","","","",1005.9,981.3,1049,1017.8,1068.7,1082.7,0.9580335731414868,-0.06185188051668678,0.18767758339484614,0.7265875973270126,0.4462379495878108,0.350433498606766,3074]
["Q9Y6M9","NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [OS=Homo sapiens]",11,1,1,1,179,21.8,8.38,3.79,"cell organization and biogenesis;other metabolic processes;transport;other biological processes","other membranes;mitochondrion","transporter activity","NDUFB9","ENSG00000147684","Oxidative phosphorylation; Metabolic pathways; Thermogenesis; Retrograde endocannabinoid signaling; Non-alcoholic fatty liver disease; Alzheimer disease; Parkinson disease; Amyotrophic lateral sclerosis; Huntington disease; Prion disease; Pathways of neurodegeneration; Chemical carcinogenesis; Diabetic cardiomyopathy","Complex I biogenesis","Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial immune response to SARS-CoV-2; Oxidative phosphorylation",26,23,24.7,23.1,29.9,33.1,0.8559814169570267,-0.22434861830177436,0.24990139104713416,0.6022313264169151,0.5092080477177316,0.29310474120890884,3587]
["Q9Y6N1","Cytochrome c oxidase assembly protein COX11, mitochondrial [OS=Homo sapiens]",12,2,10,2,276,31.4,9.06,13.74,"other metabolic processes;other biological processes","other membranes;mitochondrion;other cell component","other molecular function","COX11","ENSG00000166260","Oxidative phosphorylation; Metabolic pathways; Thermogenesis","Cytoprotection by HMOX1; Respiratory electron transport; TP53 Regulates Metabolic Genes","Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis; Mitochondrial complex IV assembly",222.8,205.8,248.4,172.4,203.8,268.9,1.0494496977212835,0.06963301695188069,0.7488405762338899,0.12561063120766808,0.8389447841345036,0.07626662169193331,6524]
["Q9Y6N5","Sulfide:quinone oxidoreductase, mitochondrial [OS=Homo sapiens]",71,29,161,29,450,49.9,9.11,531.19,"other metabolic processes","other membranes;mitochondrion","other molecular function","SQOR","ENSG00000137767","Sulfur metabolism; Metabolic pathways","Sulfide oxidation to sulfate","",20269.8,19241.7,20747.1,17622.6,17755.9,13034,1.2446909372579396,0.3157875586482203,0.07076954285013351,1.1501536097968286,0.29010352702839365,0.5374469910882103,1783]
["Q9Y6N7","Roundabout homolog 1 [OS=Homo sapiens]",4,7,11,6,1651,180.8,6.04,21.23,"cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;ER/Golgi;other cell component","other molecular function","ROBO1","ENSG00000169855","Axon guidance","Regulation of expression of SLITs and ROBOs; Netrin-1 signaling; Regulation of cortical dendrite branching; Regulation of commissural axon pathfinding by SLIT and ROBO; Role of ABL in ROBO-SLIT signaling; Inactivation of CDC42 and RAC1; Activation of RAC1; SLIT2:ROBO1 increases RHOA activity","Development of ureteric collection system",662.2,691.1,652,598.1,611.8,959.3,0.9244421906693714,-0.11334499033877696,0.6693924903439854,0.17431916413310014,0.7870961570019609,0.10397220804198506,6216]
["Q9Y6P5-2","Isoform T1 of Sestrin-1 [OS=Homo sapiens]",25,13,29,13,551,63.8,6.3,95.15,"","","","SESN1","","","","",2784,3002.1,2897.4,3211.2,2917.4,3065.4,0.9444746573852513,-0.08241600886676885,0.18250310569950476,0.7387297406503505,0.4402360394579803,0.3563144072686825,3030]
["Q9Y6Q9-1","Nuclear receptor coactivator 3 [OS=Homo sapiens]",3,3,4,3,1424,155.2,7.47,12.25,"protein metabolism;other metabolic processes;other biological processes","cytosol;nucleus;other cell component","other molecular function","NCOA3","ENSG00000124151","Endocrine resistance; Estrogen signaling pathway; Thyroid hormone signaling pathway; Pathways in cancer; Breast cancer","PPARA activates gene expression; Estrogen-dependent gene expression; Transcriptional regulation of white adipocyte differentiation; MAPK6/MAPK4 signaling; Activation of anterior HOX genes in hindbrain development during early embryogenesis","Androgen receptor signaling pathway; Integrated breast cancer pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Breast cancer pathway; EGF/EGFR signaling pathway",279.3,283.6,261.5,425.3,437.5,519.3,{"$f":"AVERAGE(S7298:U7298)/AVERAGE(V7298:X7298)","v":0.5964836118949425},{"$f":"LOG(Y7298,2)","v":-0.7454455937861109},{"$f":"TTEST(V7298:X7298,S7298:U7298,2,2)","v":3.5670042867921936E-3},2.44769636873031,{"$f":"AA7298*7309/AE7298","v":0.07556879516569316},1.121657501919611,345]
["Q9Y6R4-1","Mitogen-activated protein kinase kinase kinase 4 [OS=Homo sapiens]",4,5,7,4,1608,181.6,6.32,20.22,"protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes","other cell component","kinase activity;other molecular function","MAP3K4","ENSG00000085511","MAPK signaling pathway; GnRH signaling pathway","","MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; EGF/EGFR signaling pathway; Insulin signaling; MAP3K1 role in promoting and blocking gonadal determination; Host-pathogen interaction of human coronaviruses - MAPK signaling; Malignant pleural mesothelioma; G13 signaling pathway; DNA damage response (only ATM dependent)",150.9,116.1,134.1,122.4,128,303.8,0.723745940093829,-0.46644474466690794,0.4457082961092111,{"$f":"-LOG10(AA7299)","v":0.35094928217830657},0.6323140404235682,{"$f":"-LOG10(AC7299)","v":0.19906717464608933},5152]
["Q9Y6R9","Coiled-coil domain-containing protein 61 [OS=Homo sapiens]",8,5,8,5,512,57.3,10.27,17.7,"cell cycle OR cell proliferation;cell organization and biogenesis","cytoskeleton;other cell component","cytoskeletal activity;other molecular function","CCDC61","ENSG00000104983","","","",408.6,386.1,377.3,539.6,528.9,625.7,0.691771927753512,-0.5316316248488638,5.5604497589010655E-3,2.2548900789378834,0.09174114511920517,1.0374358432769801,443]
["Q9Y6V0-1","Protein piccolo [OS=Homo sapiens]",0,1,6,1,5065,552.9,6.51,12.09,"","","","","","","","",690.1,664.8,656.2,503.2,483.7,692.5,1.19751101583899,0.2600389272960565,0.17605838272151075,0.7543432919057862,0.4338539175021989,0.36265647671417645,2966]
["Q9Y6V7","Probable ATP-dependent RNA helicase ddx49 [OS=Homo sapiens]",10,3,4,3,483,54.2,9.06,15.77,"RNA metabolism OR transcription;other metabolic processes;other biological processes","nucleus","other molecular function","DDX49","ENSG00000105671","","Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol","",373.1,384.7,351.7,690.1,672.8,426,0.6202135390463412,-0.6891630750609529,0.0576904271620931,1.2388962453467094,0.2614131011331299,0.5826726508516981,1613]
["Q9Y6W3","Calpain-7 [OS=Homo sapiens]",18,12,25,12,813,92.6,7.65,63.85,"protein metabolism;other biological processes","cytosol;cytoskeleton;nucleus","other molecular function","CAPN7","ENSG00000131375","","Degradation of the extracellular matrix","Integrin-mediated cell adhesion",2955.6,2881.9,2783,3159.8,3240.7,2513.4,0.9670851142597517,-0.04828522636758504,0.6992503800491239,0.15536728891325674,0.805996061785057,0.09366708021624531,6341]
["Q9Y6W5","Wiskott-Aldrich syndrome protein family member 2 [OS=Homo sapiens]",24,13,44,12,498,54.3,5.53,115.77,"cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes","plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component","cytoskeletal activity;other molecular function","WASF2","ENSG00000158195","Adherens junction; Fc gamma R-mediated phagocytosis; Regulation of actin cytoskeleton; Bacterial invasion of epithelial cells; Pathogenic Escherichia coli infection; Shigellosis; Yersinia infection; Choline metabolism in cancer","Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RAC2 GTPase cycle; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway","Regulation of actin cytoskeleton",5741.7,5534.6,5660.8,5647.1,5771.9,5427.9,1.0053541007544413,0.007703729688463802,0.8102156460675651,0.0913993744143443,0.8804439722134751,0.0552982755089881,6726]
["Q9Y6X3-1","MAU2 chromatid cohesion factor homolog [OS=Homo sapiens]",7,3,4,3,613,69,7.25,16.13,"cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes","nucleus;other cell component","nucleic acid binding activity;other molecular function","MAU2","ENSANAG00000026794; ENSCANG00000033671; ENSCATG00000015302; ENSCCAG00000031923; ENSCSAG00000005122; ENSG00000129933; ENSGGOG00000002989; ENSMFAG00000041829; ENSMNEG00000034232; ENSPPAG00000032359; ENSPTRG00000010738; ENSRBIG00000036077; ENSRROG00000032649; ENSSBOG00000034577","","Cohesin Loading onto Chromatin","Cohesin complex - Cornelia de Lange syndrome",419.7,400.9,393.7,333.8,303.7,285.3,1.3158864325964457,0.39603498284219635,3.8185760394265924E-3,2.418098556855392,0.07688697595638833,1.1141472200075315,363]
["Q9Y6X4-1","Soluble lamin-associated protein of 75 kDa [OS=Homo sapiens]",6,4,6,4,670,74.9,4.6,19.28,"","other membranes;nucleus","","FAM169A","ENSG00000198780","","RHOF GTPase cycle","",512.9,532.8,569.2,482.1,513.4,352,1.1984415584415582,0.26115955821335635,0.16224278852874635,0.7898345978975483,0.4194667638332533,0.3773024445030949,2827]
["Q9Y6X5","Bis(5'-adenosyl)-triphosphatase ENPP4 [OS=Homo sapiens]",11,5,11,5,453,51.6,6.15,29.68,"other metabolic processes;stress response;other biological processes","plasma membrane;other membranes","other molecular function","ENPP4","ENSG00000001561","Purine metabolism; Metabolic pathways","Neutrophil degranulation","",971.1,926.5,930.1,854.5,909,930,1.049823649526638,0.07014700282373493,0.1686793550735173,0.7729380681299517,0.42542353562192475,0.37117848738113446,2898]
["Q9Y6X9-1","MORC family CW-type zinc finger protein 2 [OS=Homo sapiens]",12,12,19,12,1032,117.8,8.38,55.94,"cell organization and biogenesis;other metabolic processes;stress response;other biological processes","cytosol;nucleus;other cell component","other molecular function","MORC2","ENSG00000133422","","Fatty acyl-CoA biosynthesis","",2524.5,2495.8,2520.2,2921,2816.5,2971.2,0.8658582796513831,-0.2077971853808364,0.001106167248302481,2.9561792043843687,0.044916535654682406,1.3475937476037019,180]
["Q9Y6Y0","influenza virus NS1A-binding protein [OS=Homo sapiens]",1,1,1,1,642,71.7,5.53,0,"RNA metabolism OR transcription;other metabolic processes;other biological processes","cytosol;cytoskeleton;nucleus;other cell component","","IVNS1ABP","ENSG00000116679","","","",61.8,52,61.4,143.5,125.7,55.5,0.5395749923005851,-0.8901046096849148,0.13926342045230933,0.8561629423119473,0.393002447909625,0.40560474450922623,2590]
["Q9Y6Y8","SEC23-interacting protein [OS=Homo sapiens]",29,26,73,26,1000,111,5.54,187.51,"cell organization and biogenesis;transport","other membranes;cytosol;ER/Golgi;other cell component","other molecular function","SEC23IP","ENSG00000107651","","COPII-mediated vesicle transport","",7351.9,7730.5,7357.4,7629.8,7327.7,8771,0.9456897823292665,-0.08056108562786173,0.40045269158464825,0.39744878294378644,0.6079993192339415,0.2160969069988246,4814]