{"text_format":"3","workbook":"xls","n_sheets":51,"sheets":["Figure 1b","Figure 1c","Figure 1d","Figure 1f","Figure 2a","Figure 2b","Figure 2c","Figure 2d","Figure 2e","Figure 2f","Figure 3b","Figure 3c","Figure 3d","Figure 3e","Figure 3f","Figure 4b","Figure 4c","Figure 4e","Figure 4f","Figure 5a","Figure 5b","Figure 5c","Figure 5e","Figure 5f","Figure 6a","Figure 6d","Figure 6e","Figure 6f","Figure 7b","Figure 7e","Figure 7f","Figure 8a","Figure 8b","Figure 8e","Figure 8f","Supplementary Figure 1","Supplementary Figure 2","Supplementary Figure 3","Supplementary Figure 4","Supplementary Figure 5","Supplementary Figure 7","Supplementary Figure 8","Supplementary Figure 9","Supplementary Figure 10","Supplementary Figure 11","Supplementary Figure 13","Supplementary Figure 14","Supplementary Figure 16","Supplementary Figure 17","Supplementary Figure 18","Supplementary Figure 19"],"not_rendered":{"images":42,"external_links":2},"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Figure 1b","index":0,"n_rows":20,"n_cols":7,"rows_kept":20,"merged":[[4,0,11,0],[4,4,11,4],[12,0,19,0],[12,4,19,4]],"flags":["formulas_cached_only"]}
["Figure 1b"]
[]
["C57/BL6J mice ALT（U/L）",{"$nulls":3},"C57/BL6J mice AST（U/L）"]
["Group","No.","ALT (U/L)",null,"Group","No.","AST (U/L)"]
["vehicle",1,24.9,null,"vehicle",1,101.7]
[null,2,32.4,null,null,2,117.4]
[null,3,{"v":30,"d":"30.0"},null,null,3,103.4]
[null,4,21.3,null,null,4,98.8]
[null,5,33.7,null,null,5,123.3]
[null,6,29.2,null,null,6,{"v":107.06,"d":"107.1"}]
[null,7,{"v":30.21,"d":"30.2"},null,null,7,{"v":91.16,"d":"91.2"}]
[null,8,{"v":29.15,"d":"29.2"},null,null,8,{"v":101.76,"d":"101.8"}]
["Regora",1,62.6,null,"Regora",1,167.7]
[null,2,66.8,null,null,2,{"v":170,"d":"170.0"}]
[null,3,67.6,null,null,3,177.5]
[null,4,82.1,null,null,4,148.7]
[null,5,75.1,null,null,5,168.4]
[null,6,67.7,null,null,6,152.6]
[null,7,86.9,null,null,7,{"v":236,"d":"236.0"}]
[null,8,59.4,null,null,8,176.7]

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["Figure 1c"]
[]
["Annexin V-FITC"]
["Apoptosis rates (%) ","Regora (μM ) for 24 h"]
[null,0,1,2,4,8]
["1st",4.39,4.57,4.22,28.21,29.07]
["2nd",3.77,4.48,6.75,8.53,34.43]
["3rd",{"v":4.1,"d":"4.10"},{"v":5,"d":"5.00"},8.04,{"v":9.7,"d":"9.70"},47.53]
[]
[]
["Apoptosis rates (%) ","Regora (μM ) for 48 h"]
[null,0,1,2,4,8]
["1st",7.17,{"v":5.8,"d":"5.80"},5.69,64.29,62.23]
["2nd",3.18,4.69,24.91,47.29,59.22]
["3rd",3.79,5.24,30.52,66.88,75.35]

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["Figure 1d"]
[]
["JC-1"]
["Regora (μM ) for 12 h","1st",null,"2nd",null,"3rd"]
[null,"Red positive cell (%)","Green positive cell (%)","Red positive cell (%)","Green positive cell (%)","Red positive cell (%)","Green positive cell (%)"]
[0,91.92,8.01,91.92,7.56,98.34,1.33]
[1,87.22,12.66,87.22,11.5,96.17,3.07]
[2,89.3,10.44,89.3,9.23,89.77,8.23]
[4,92.25,6.84,92.25,6.45,58.25,36.99]
[8,38.74,56.7,38.74,57.89,0.49,99.41]
[]
["Regora (μM ) for 24 h","1st",null,"2nd",null,"3rd"]
[null,"Red positive cell (%)","Green positive cell (%)","Red positive cell (%)","Green positive cell (%)","Red positive cell (%)","Green positive cell (%)"]
[0,88.33,11.66,89.28,10.82,92.93,5.53]
[1,74.66,25.3,77.04,23.26,93.82,4.79]
[2,73.97,25.62,78.83,21.99,89.35,8.77]
[4,83.95,13.85,87.6,13.45,28.86,67]
[8,25.81,70.21,31.87,70.66,0.42,99.43]

{"sheet":"Figure 1f","index":3,"n_rows":9,"n_cols":4,"rows_kept":9,"flags":["formulas_cached_only"]}
["Figure 1f"]
[]
[null,"c-PARP/GAPDH protein expression of mice"]
[null,"NO.","Vehicle","Regora"]
[null,1,{"v":0.586974,"d":"0.59"},{"v":3.199893,"d":"3.20"}]
[null,2,{"v":0.499348,"d":"0.50"},{"v":3.184491,"d":"3.18"}]
[null,3,{"v":0.906512,"d":"0.91"},{"v":1.919242,"d":"1.92"}]
[null,4,{"v":2.271943,"d":"2.27"},{"v":3.690608,"d":"3.69"}]
[null,5,{"v":0.735223,"d":"0.74"},{"v":1.264963,"d":"1.26"}]

{"sheet":"Figure 2a","index":4,"n_rows":10,"n_cols":4,"rows_kept":10,"flags":["formulas_cached_only"]}
["Figure 2a"]
[]
[null,"p53/GAPDH protein expression of mice"]
[null,"NO.","Vehicle","Regora"]
[null,1,{"v":0.371657003,"d":"0.37"},{"v":7.946139095,"d":"7.95"}]
[null,2,{"v":1.032157458,"d":"1.03"},{"v":3.849446317,"d":"3.85"}]
[null,3,{"v":1.294990342,"d":"1.29"},{"v":5.88638122,"d":"5.89"}]
[null,4,{"v":0.652034577,"d":"0.65"},{"v":5.208413241,"d":"5.21"}]
[null,5,{"v":1.579544617,"d":"1.58"},{"v":4.912231394,"d":"4.91"}]
[null,6,{"v":1.069616003,"d":"1.07"},{"v":4.055347812,"d":"4.06"}]

{"sheet":"Figure 2b","index":5,"n_rows":8,"n_cols":7,"rows_kept":8,"merged":[[3,1,4,1],[3,2,3,6]],"flags":["formulas_cached_only"]}
["Figure 2b"]
[]
[null,"c-PARP/GAPDH protein expression of HPH"]
[null,"Fold change","Regora (μM)"]
[null,null,0,1,2,4,8]
[null,"HPH-1",{"v":1,"d":"1.00"},{"v":1.154221,"d":"1.15"},{"v":1.013559,"d":"1.01"},{"v":1.541451,"d":"1.54"},{"v":2.252057,"d":"2.25"}]
[null,"HPH-2",{"v":1,"d":"1.00"},{"v":1.586317,"d":"1.59"},{"v":1.641688,"d":"1.64"},{"v":2.100142,"d":"2.10"},{"v":2.592617,"d":"2.59"}]
[null,"HPH-3",{"v":1,"d":"1.00"},{"v":1.864298,"d":"1.86"},{"v":1.7474,"d":"1.75"},{"v":1.534418,"d":"1.53"},{"v":2.115409,"d":"2.12"}]

{"sheet":"Figure 2c","index":6,"n_rows":7,"n_cols":6,"rows_kept":7,"flags":["formulas_cached_only"]}
["Figure 2c"]
[]
[null,"Survival rates of HL-7702 "]
[null,"Survival rates (%) ","NC","NC+Regora","sip53","sip53+Regora"]
[null,"1st",{"v":100,"d":"100.00"},{"v":30.98238,"d":"30.98"},{"v":97.76706,"d":"97.77"},{"v":44.13249,"d":"44.13"}]
[null,"2nd",{"v":100,"d":"100.00"},{"v":30.99159,"d":"30.99"},{"v":98.65993,"d":"98.66"},{"v":40.95237,"d":"40.95"}]
[null,"3rd",{"v":100,"d":"100.00"},{"v":33.10417,"d":"33.10"},{"v":101.957,"d":"101.96"},{"v":48.439,"d":"48.44"}]

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["Figure 2d"]
[]
[null,"c-PARP/GAPDH protein expression of HPH"]
[null,"Fold change","NC","NC + Regora","sip53","sip53 + Regora"]
[null,"HPH-1",{"v":1,"d":"1.00"},{"v":2.913641,"d":"2.91"},{"v":1.669588,"d":"1.67"},{"v":1.685965,"d":"1.69"}]
[null,"HPH-2",{"v":1,"d":"1.00"},{"v":2.413999,"d":"2.41"},{"v":0.985975,"d":"0.99"},{"v":1.335601,"d":"1.34"}]
[null,"HPH-3",{"v":1,"d":"1.00"},{"v":2.494577,"d":"2.49"},{"v":0.831088,"d":"0.83"},{"v":1.340007,"d":"1.34"}]
[]
[null,"p53/GAPDH protein expression of HPH"]
[null,"Fold change","NC","NC + Regora","sip53","sip53 + Regora"]
[null,"HPH-1",{"v":1,"d":"1.00"},{"v":2.589888,"d":"2.59"},{"v":0.244811,"d":"0.24"},{"v":1.068571,"d":"1.07"}]
[null,"HPH-2",{"v":1,"d":"1.00"},{"v":1.789171,"d":"1.79"},{"v":0.022597,"d":"0.02"},{"v":0.026234,"d":"0.03"}]
[null,"HPH-3",{"v":1,"d":"1.00"},{"v":3.176727,"d":"3.18"},{"v":0.217799,"d":"0.22"},{"v":0.728374,"d":"0.73"}]

{"sheet":"Figure 2e","index":8,"n_rows":7,"n_cols":6,"rows_kept":7,"flags":["formulas_cached_only"]}
["Figure 2e"]
[]
[null,"Annexin V-FITC"]
[null,"Apoptosis rates (%) ","NC","NC+Regora","sip53","sip53+Regora"]
[null,"1st",3.98,49.1,4.2,41.73]
[null,"2nd",4.46,59.19,4.92,48.21]
[null,"3rd",4.07,52.76,3.96,35.39]

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["Figure 2f"]
[]
[null,"JC-1"]
[null,null,"1st",null,"2nd",null,"3rd",null,"4th"]
[null,null,"Red positive cell (%)","Green positive cell (%)","Red positive cell (%)","Green positive cell (%)","Red positive cell (%)","Green positive cell (%)","Red positive cell (%)","Green positive cell (%)"]
[null,"NC",98.97,0.98,97.06,2.88,91.7,8.57,93.22,7.09]
[null,"NC+Regora",11.02,85.98,14.46,87.18,11.23,89.03,13.34,86.14]
[null,"sip53",96.94,3.03,99.06,0.89,90.56,9.51,91.15,9.21]
[null,"sip53+Regora",83.77,16.34,96.78,3.37,81.04,19.24,74.42,25.91]

{"sheet":"Figure 3b","index":10,"n_rows":7,"n_cols":6,"rows_kept":7,"flags":["formulas_cached_only"]}
["Figure 3b"]
[]
[null,"Survival rates of HL-7702 "]
[null,"Survival rates (%)","NC","NC+Regora","siEphA2","siEphA2+Regora"]
[null,"1st",{"v":100,"d":"100.00"},{"v":50.82223,"d":"50.82"},{"v":98.49376,"d":"98.49"},{"v":72.046,"d":"72.05"}]
[null,"2nd",{"v":100,"d":"100.00"},{"v":33.1835,"d":"33.18"},{"v":103.8315,"d":"103.83"},{"v":79.39381,"d":"79.39"}]
[null,"3rd",{"v":100,"d":"100.00"},{"v":34.87419,"d":"34.87"},{"v":98.85898,"d":"98.86"},{"v":75.0644,"d":"75.06"}]

{"sheet":"Figure 3c","index":11,"n_rows":19,"n_cols":6,"rows_kept":19,"flags":["formulas_cached_only"]}
["Figure 3c"]
[]
[null,"c-PARP/GAPDH protein expression of HL-7702"]
[null,"Fold change","NC","NC+Regora","siEphA2","siEphA2+Regora"]
[null,"1st",{"v":1,"d":"1.00"},{"v":3.398052,"d":"3.40"},{"v":1.280058,"d":"1.28"},{"v":0.87224,"d":"0.87"}]
[null,"2nd",{"v":1,"d":"1.00"},{"v":4.395509,"d":"4.40"},{"v":1.365034,"d":"1.37"},{"v":0.700712,"d":"0.70"}]
[null,"3rd",{"v":1,"d":"1.00"},{"v":3.932735,"d":"3.93"},{"v":0.455952,"d":"0.46"},{"v":1.697935,"d":"1.70"}]
[]
[null,"EphA2/GAPDH protein expression of HL-7702"]
[null,"Fold change","NC","NC+Regora","siEphA2","siEphA2+Regora"]
[null,"1st",{"v":1,"d":"1.00"},{"v":1.019577,"d":"1.02"},{"v":0.551596,"d":"0.55"},{"v":0.290283,"d":"0.29"}]
[null,"2nd",{"v":1,"d":"1.00"},{"v":0.930285,"d":"0.93"},{"v":0.454226,"d":"0.45"},{"v":0.176737,"d":"0.18"}]
[null,"3rd",{"v":1,"d":"1.00"},{"v":0.80892,"d":"0.81"},{"v":0.422761,"d":"0.42"},{"v":0.345459,"d":"0.35"}]
[]
[null,"p53/GAPDH protein expression of HL-7702"]
[null,"Fold change","NC","NC+Regora","siEphA2","siEphA2+Regora"]
[null,"1st",{"v":1,"d":"1.00"},{"v":3.226277,"d":"3.23"},{"v":0.629339,"d":"0.63"},{"v":1.146005,"d":"1.15"}]
[null,"2nd",{"v":1,"d":"1.00"},{"v":3.512521,"d":"3.51"},{"v":0.517707,"d":"0.52"},{"v":1.111781,"d":"1.11"}]
[null,"3rd",{"v":1,"d":"1.00"},{"v":1.947574,"d":"1.95"},{"v":1.025381,"d":"1.03"},{"v":0.951534,"d":"0.95"}]

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["Figure 3d"]
[]
[null,"C57/BL6J mice ALT（U/L）",{"$nulls":3},"C57/BL6J mice AST（U/L）"]
[null,"Group","No.","ALT (U/L)",null,"Group","No.","AST (U/L)"]
[null,"AAV8-Control",1,29.8,null,"AAV8-Control",1,95.7]
[null,null,2,29.5,null,null,2,99.3]
[null,null,3,32.1,null,null,3,116.8]
[null,null,4,33.5,null,null,4,115.4]
[null,null,5,{"v":34.98,"d":"35.0"},null,null,5,{"v":89.57,"d":"89.6"}]
[null,null,6,37.1,null,null,6,{"v":87.98,"d":"88.0"}]
[null,null,7,{"v":25.97,"d":"26.0"},null,null,7,{"v":94.86999999999999,"d":"94.9"}]
[null,null,8,31.5,null,null,8,119.8]
[null,"AAV8-Control+Regora",1,55.9,null,"AAV8-Control+Regora",1,181.1]
[null,null,2,72.2,null,null,2,161.3]
[null,null,3,60.4,null,null,3,121.3]
[null,null,4,62.3,null,null,4,179.5]
[null,null,5,64.6,null,null,5,237.7]
[null,null,6,61.3,null,null,6,180.4]
[null,null,7,45.2,null,null,7,172.2]
[null,null,8,49.6,null,null,8,178.2]
[null,"AAV8-shEphA2",1,32.4,null,"AAV8-shEphA2",1,94.7]
[null,null,2,26.4,null,null,2,113.5]
[null,null,3,33.1,null,null,3,{"v":91,"d":"91.0"}]
[null,null,4,{"v":32.86,"d":"32.9"},null,null,4,97.2]
[null,null,5,{"v":32.33,"d":"32.3"},null,null,5,96.7]
[null,null,6,31.8,null,null,6,112.1]
[null,null,7,26.5,null,null,7,118.6]
[null,null,8,30.3,null,null,8,113.1]
[null,"AAV8-shEphA2+Regora",1,27.9,null,"AAV8-shEphA2+Regora",1,131.1]
[null,null,2,26.7,null,null,2,{"v":121,"d":"121.0"}]
[null,null,3,{"v":40.28,"d":"40.3"},null,null,3,113.2]
[null,null,4,{"v":30.21,"d":"30.2"},null,null,4,{"v":123,"d":"123.0"}]
[null,null,5,{"v":42.93,"d":"42.9"},null,null,5,130.2]
[null,null,6,27.3,null,null,6,{"v":101,"d":"101.0"}]
[null,null,7,31.4,null,null,7,94.1]
[null,null,8,29.2,null,null,8,135.4]

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["Figure 3e"]
[]
[null,"IHC analysis (p53)"]
[null,"Fold change","No.","Inrensity (a.u.)"]
[null,"AAV8-Control",1,{"v":0.95400341,"d":"0.95"}]
[null,null,2,{"v":0.93696763,"d":"0.94"}]
[null,null,3,{"v":1.01362862,"d":"1.01"}]
[null,null,4,{"v":1.04770017,"d":"1.05"}]
[null,null,5,{"v":1.04770017,"d":"1.05"}]
[null,"AAV8-Control+Regora",1,{"v":2.078365,"d":"2.08"}]
[null,null,2,{"v":2.069847,"d":"2.07"}]
[null,null,3,{"v":1.942078,"d":"1.94"}]
[null,null,4,{"v":1.65247,"d":"1.65"}]
[null,null,5,{"v":1.609881,"d":"1.61"}]
[null,"AAV8-shEphA2",1,{"v":0.962521,"d":"0.96"}]
[null,null,2,{"v":1.005111,"d":"1.01"}]
[null,null,3,{"v":0.88586,"d":"0.89"}]
[null,null,4,{"v":0.843271,"d":"0.84"}]
[null,null,5,{"v":0.834753,"d":"0.83"}]
[null,"AAV8-shEphA2+Regora",1,{"v":1.064736,"d":"1.06"}]
[null,null,2,{"v":0.954003,"d":"0.95"}]
[null,null,3,{"v":1.311755,"d":"1.31"}]
[null,null,4,{"v":1.345826,"d":"1.35"}]
[null,null,5,{"v":1.201022,"d":"1.20"}]

{"sheet":"Figure 3f","index":14,"n_rows":9,"n_cols":6,"rows_kept":9,"flags":["formulas_cached_only"]}
["Figure 3f"]
[]
[null,"p53/GAPDH protein expression of mice"]
[null,"NO.","AAV8-Control","AAV8-Control+Regora","AAV8-shEphA2","AAV8-shEphA2+Regora"]
[null,1,{"v":0.651149,"d":"0.65"},{"v":2.849353,"d":"2.85"},{"v":0.662605,"d":"0.66"},{"v":2.62788,"d":"2.63"}]
[null,2,{"v":1.348851,"d":"1.35"},{"v":2.92037,"d":"2.92"},{"v":0.561756,"d":"0.56"},{"v":1.146781,"d":"1.15"}]
[null,3,{"v":1.190162,"d":"1.19"},{"v":2.736819,"d":"2.74"},{"v":1.555413,"d":"1.56"},{"v":1.306367,"d":"1.31"}]
[null,4,{"v":0.964847,"d":"0.96"},{"v":9.133313,"d":"9.13"},{"v":1.121579,"d":"1.12"},{"v":1.909732,"d":"1.91"}]
[null,5,{"v":0.84499,"d":"0.84"},{"v":5.940383,"d":"5.94"},{"v":1.093751,"d":"1.09"},{"v":1.117416,"d":"1.12"}]

{"sheet":"Figure 4b","index":15,"n_rows":20,"n_cols":7,"rows_kept":20,"merged":[[3,1,4,1],[3,2,3,6],[15,1,16,1],[15,2,15,6]],"flags":["formulas_cached_only"]}
["Figure 4b"]
[]
[null,"pS-EphA2/GAPDH protein expression of HL-7702"]
[null,"Fold change","Regora (μM)"]
[null,null,0,1,2,4,8]
[null,"1st",{"v":1,"d":"1.00"},{"v":0.586603,"d":"0.59"},{"v":0.114674,"d":"0.11"},{"v":0.114923,"d":"0.11"},{"v":0.016509,"d":"0.02"}]
[null,"2nd",{"v":1,"d":"1.00"},{"v":0.56731,"d":"0.57"},{"v":0.091065,"d":"0.09"},{"v":0.079789,"d":"0.08"},{"v":0.01045,"d":"0.01"}]
[null,"3st",{"v":1,"d":"1.00"},{"v":0.664345,"d":"0.66"},{"v":0.362169,"d":"0.36"},{"v":0.179118,"d":"0.18"},{"v":0.102331,"d":"0.10"}]
[]
[]
[]
[]
[]
[]
[null,"pS-EphA2/GAPDH protein expression of HL-7702"]
[null,"Fold change","Regora 8 μM (h)"]
[null,null,0,3,6,12,24]
[null,"1st",{"v":1,"d":"1.00"},{"v":0.493508,"d":"0.49"},{"v":0.405367,"d":"0.41"},{"v":0.358395,"d":"0.36"},{"v":0.234885,"d":"0.23"}]
[null,"2nd",{"v":1,"d":"1.00"},{"v":0.490964,"d":"0.49"},{"v":0.330361,"d":"0.33"},{"v":0.27364,"d":"0.27"},{"v":0.146036,"d":"0.15"}]
[null,"3st",{"v":1,"d":"1.00"},{"v":0.696789,"d":"0.70"},{"v":0.339358,"d":"0.34"},{"v":0.153099,"d":"0.15"},{"v":0.072069,"d":"0.07"}]

{"sheet":"Figure 4c","index":16,"n_rows":1,"n_cols":1,"rows_kept":1,"flags":["formulas_cached_only"]}
["Figure 4c"]

{"sheet":"Figure 4e","index":17,"n_rows":9,"n_cols":13,"rows_kept":9,"merged":[[3,0,4,0],[3,1,3,4],[3,5,3,8],[3,9,3,12]],"flags":["formulas_cached_only"]}
["Figure 4e"]
[]
["p53/GAPDH protein expression of HL-7702"]
["Fold  change","CHX + Vector",{"$nulls":3},"CHX + EphA2-S897A-HA",{"$nulls":3},"CHX + EphA2-S897D-HA"]
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["Figure 4f"]
[]
[null,"p53/GAPDH protein expression of HL-7702"]
[null,"Fold change","Vector","Vector + Regora","EphA2-S897D","EphA2-S897D + Regora"]
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["Figure 5a"]
[]
[null,"pS-MDM2/GAPDH protein expression of HL-7702"]
[null,"Fold change","Regora (μM)"]
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[]
[null,"pS-MDM2/GAPDH protein expression of HL-7702"]
[null,"Fold change","Regora 8 μM (h)"]
[null,null,0,3,6,12,24]
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["Figure 5f"]
[]
[null,"pS-MDM2/GAPDH protein expression of HL-7702"]
[null,"Fold change","Regora (μM)"]
[null,null,0,1,2,4,8]
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["Figure 6a"]
[]
[null,"C57/BL6J mice ALT（U/L）",{"$nulls":3},"C57/BL6J mice AST（U/L）"]
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["Figure 6d"]
[]
[null,"IHC analysis (pS-MDM2)",{"$nulls":3},"IHC analysis (p53)"]
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["Figure 6e"]
[]
[null,"pS-MDM2/GAPDH protein expression of mice"]
[null,"NO.","AAV8-Vector","AAV8-EphA2-S898A"]
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[]
[null,"p53/GAPDH protein expression of mice"]
[null,"NO.","AAV8-Vector","AAV8-EphA2-S898A"]
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[]
[null,"c-PARP/GAPDH protein expression of mice"]
[null,"NO.","AAV8-Vector","AAV8-EphA2-S898A"]
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["Figure 7b"]
[]
[null,"C57/BL6J mice ALT（U/L）",{"$nulls":3},"C57/BL6J mice AST（U/L）"]
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["Figure 7e"]
[]
[null,"IHC analysis (pS-MDM2)"]
[null,"Group","No.","Inrensity (a.u.)"]
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["Figure 7f"]
[]
[null,"IHC analysis (pS-MDM2)"]
[null,"Group","No.","Inrensity (a.u.)"]
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["Figure 8a"]
[]
[null,"pS-EphA2/GAPDH protein expression of HL-7702"]
[null,"Fold change","Schi  C (μM)"]
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[]
[null,"p53/GAPDH protein expression of HL-7702"]
[null,"Fold change","Schi  C (μM)"]
[null,null,0,10,20,30,40,50]
[null,"1st",{"v":1,"d":"1.00"},{"v":0.861542,"d":"0.86"},{"v":0.658538,"d":"0.66"},{"v":0.456913,"d":"0.46"},{"v":0.35004,"d":"0.35"},{"v":0.468731,"d":"0.47"}]
[null,"2nd",{"v":1,"d":"1.00"},{"v":1.057961,"d":"1.06"},{"v":0.832151,"d":"0.83"},{"v":0.526554,"d":"0.53"},{"v":0.522877,"d":"0.52"},{"v":0.566889,"d":"0.57"}]
[null,"3rd",{"v":1,"d":"1.00"},{"v":1.051395,"d":"1.05"},{"v":0.785399,"d":"0.79"},{"v":0.390024,"d":"0.39"},{"v":0.302101,"d":"0.30"},{"v":0.46115,"d":"0.46"}]

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["Figure 8b"]
[]
[null,"C57/BL6J mice ALT（U/L）",{"$nulls":3},"C57/BL6J mice AST（U/L）"]
[null,"Group","No.","ALT (U/L)",null,"Group","No.","AST (U/L)"]
[null,"Vehicle",1,27.3,null,"Vehicle",1,106.8]
[null,null,2,33.4,null,null,2,146.1]
[null,null,3,37.4,null,null,3,145.2]
[null,null,4,37.1,null,null,4,{"v":108,"d":"108.0"}]
[null,null,5,34.7,null,null,5,128.4]
[null,null,6,32.4,null,null,6,103.2]
[null,null,7,31.2,null,null,7,104.4]
[null,null,8,33.6,null,null,8,{"v":126,"d":"126.0"}]
[null,"Regora",1,99.8,null,"Regora",1,238.5]
[null,null,2,76.6,null,null,2,286.6]
[null,null,3,87.4,null,null,3,220.7]
[null,null,4,84.1,null,null,4,155.7]
[null,null,5,97.2,null,null,5,188.4]
[null,null,6,94.8,null,null,6,{"v":156,"d":"156.0"}]
[null,null,7,74.7,null,null,7,228.6]
[null,null,8,67.2,null,null,8,190.8]
[null,"Schi C",1,31.6,null,"Schi C",1,139.6]
[null,null,2,40.8,null,null,2,138.2]
[null,null,3,34.5,null,null,3,132.6]
[null,null,4,29.1,null,null,4,151.4]
[null,null,5,26.4,null,null,5,122.4]
[null,null,6,{"v":36,"d":"36.0"},null,null,6,119.2]
[null,null,7,31.7,null,null,7,{"v":134,"d":"134.0"}]
[null,null,8,44.4,null,null,8,128.4]
[null,"Schi C + Regora",1,32.4,null,"Schi C + Regora",1,169.2]
[null,null,2,{"v":46,"d":"46.0"},null,null,2,117.5]
[null,null,3,47.6,null,null,3,139.1]
[null,null,4,40.2,null,null,4,160.2]
[null,null,5,44.4,null,null,5,94.4]
[null,null,6,49.2,null,null,6,169.6]
[null,null,7,41.1,null,null,7,{"v":162,"d":"162.0"}]
[null,null,8,51.6,null,null,8,129.2]

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[]
[]
[null,"IHC analysis (pY-ERK)",{"$nulls":3},"IHC analysis (pS-MDM2)",{"$nulls":3},"IHC analysis (p53)"]
[null,"Fold change","No.","Inrensity (a.u.)",null,"Fold change","No.","Inrensity (a.u.)",null,"Fold change","No.","Inrensity (a.u.)"]
[null,"Vehicle",1,{"v":1.127551,"d":"1.13"},null,"Vehicle",1,{"v":1.1056683,"d":"1.11"},null,"Vehicle",1,{"v":0.951195219,"d":"0.95"}]
[null,null,2,{"v":1,"d":"1.00"},null,null,2,{"v":1.1126662,"d":"1.11"},null,null,2,{"v":1.015936255,"d":"1.02"}]
[null,null,3,{"v":0.959184,"d":"0.96"},null,null,3,{"v":0.944716585,"d":"0.94"},null,null,3,{"v":1.030876494,"d":"1.03"}]
[null,null,4,{"v":0.94898,"d":"0.95"},null,null,4,{"v":0.937718684,"d":"0.94"},null,null,4,{"v":1.030876494,"d":"1.03"}]
[null,null,5,{"v":0.964286,"d":"0.96"},null,null,5,{"v":0.899230231,"d":"0.90"},null,null,5,{"v":0.971115538,"d":"0.97"}]
[null,"Regora",1,{"v":0.520408,"d":"0.52"},null,"Regora",1,{"v":0.584324703,"d":"0.58"},null,"Regora",1,{"v":1.354581673,"d":"1.35"}]
[null,null,2,{"v":0.545918,"d":"0.55"},null,null,2,{"v":0.55283415,"d":"0.55"},null,null,2,{"v":1.434262948,"d":"1.43"}]
[null,null,3,{"v":0.5,"d":"0.50"},null,null,3,{"v":0.66829951,"d":"0.67"},null,null,3,{"v":1.573705179,"d":"1.57"}]
[null,null,4,{"v":0.571429,"d":"0.57"},null,null,4,{"v":0.762771169,"d":"0.76"},null,null,4,{"v":1.319721116,"d":"1.32"}]
[null,null,5,{"v":0.545918,"d":"0.55"},null,null,5,{"v":0.717284815,"d":"0.72"},null,null,5,{"v":1.269920319,"d":"1.27"}]
[null,"Schi C",1,{"v":1.403061,"d":"1.40"},null,"Schi C",1,{"v":1.249125,"d":"1.25"},null,"Schi C",1,{"v":0.577689,"d":"0.58"}]
[null,null,2,{"v":1.209184,"d":"1.21"},null,null,2,{"v":1.305108,"d":"1.31"},null,null,2,{"v":0.557769,"d":"0.56"}]
[null,null,3,{"v":1.188776,"d":"1.19"},null,null,3,{"v":1.305108,"d":"1.31"},null,null,3,{"v":0.562749,"d":"0.56"}]
[null,null,4,{"v":1.05102,"d":"1.05"},null,null,4,{"v":1.070679,"d":"1.07"},null,null,4,{"v":0.557769,"d":"0.56"}]
[null,null,5,{"v":1.132653,"d":"1.13"},null,null,5,{"v":1.207138,"d":"1.21"},null,null,5,{"v":0.567729,"d":"0.57"}]
[null,"Schi C + Regora",1,{"v":0.897959,"d":"0.90"},null,"Schi C + Regora",1,{"v":0.804759,"d":"0.80"},null,"Schi C + Regora",1,{"v":1.294821,"d":"1.29"}]
[null,null,2,{"v":0.877551,"d":"0.88"},null,null,2,{"v":0.797761,"d":"0.80"},null,null,2,{"v":1.130478,"d":"1.13"}]
[null,null,3,{"v":0.969388,"d":"0.97"},null,null,3,{"v":0.892232,"d":"0.89"},null,null,3,{"v":0.961155,"d":"0.96"}]
[null,null,4,{"v":0.887755,"d":"0.89"},null,null,4,{"v":0.927222,"d":"0.93"},null,null,4,{"v":0.946215,"d":"0.95"}]
[null,null,5,{"v":0.933673,"d":"0.93"},null,null,5,{"v":0.951714,"d":"0.95"},null,null,5,{"v":1.065737,"d":"1.07"}]

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["Figure 8f"]
[]
[null,"pS-EphA2/GAPDH protein expression of mice"]
[null,"NO.","Vehicle","Regora","Schi C","Combinition"]
[null,1,{"v":1.09436,"d":"1.09"},{"v":0.147577,"d":"0.15"},{"v":0.702345,"d":"0.70"},{"v":0.297424,"d":"0.30"}]
[null,2,{"v":1.306696,"d":"1.31"},{"v":0.099261,"d":"0.10"},{"v":0.529108,"d":"0.53"},{"v":0.298508,"d":"0.30"}]
[null,3,{"v":0.598944,"d":"0.60"},{"v":0.089048,"d":"0.09"},{"v":0.382591,"d":"0.38"},{"v":0.654245,"d":"0.65"}]
[null,4,{"v":1.190732,"d":"1.19"},{"v":0.003258,"d":"0.00"},{"v":1.255982,"d":"1.26"},{"v":0.876637,"d":"0.88"}]
[null,5,{"v":0.809268,"d":"0.81"},{"v":0.057379,"d":"0.06"},{"v":1.043113,"d":"1.04"},{"v":2.503756,"d":"2.50"}]
[]
[null,"p53/GAPDH protein expression of mice"]
[null,"NO.","Vehicle","Regora","Schi C","Combinition"]
[null,1,{"v":1.114191,"d":"1.11"},{"v":2.529156,"d":"2.53"},{"v":0.768795,"d":"0.77"},{"v":1.070412,"d":"1.07"}]
[null,2,{"v":0.933255,"d":"0.93"},{"v":3.252979,"d":"3.25"},{"v":1.54818,"d":"1.55"},{"v":0.848377,"d":"0.85"}]
[null,3,{"v":0.952554,"d":"0.95"},{"v":2.876228,"d":"2.88"},{"v":0.796037,"d":"0.80"},{"v":0.760173,"d":"0.76"}]
[null,4,{"v":1.079298,"d":"1.08"},{"v":9.998329,"d":"10.00"},{"v":1.121618,"d":"1.12"},{"v":0.328436,"d":"0.33"}]
[null,5,{"v":0.920702,"d":"0.92"},{"v":8.673876,"d":"8.67"},{"v":0.828184,"d":"0.83"},{"v":0.305133,"d":"0.31"}]

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["Supplementary Figure 1"]
[]
[null,"C57/BL6J mice ALT (U/L)",{"$nulls":3},"C57/BL6J mice AST (U/L)"]
[null,"Group","No.","ALT (U/L)",null,"Group","No.","AST (U/L)"]
[null,"Vehicle",1,26.3,null,"Vehicle",1,100.7]
[null,null,2,36.9,null,null,2,117.5]
[null,null,3,35.9,null,null,3,107.8]
[null,null,4,26.5,null,null,4,101.8]
[null,null,5,26.2,null,null,5,91.7]
[null,"Regora 200 mg/kg",1,33.2,null,"Regora 200 mg/kg",1,126.3]
[null,null,2,40,null,null,2,106.5]
[null,null,3,41.2,null,null,3,118.8]
[null,null,4,30.7,null,null,4,123.1]
[null,null,5,33.4,null,null,5,102.4]
[null,"Regora 400 mg/kg",1,51.1,null,"Regora 400 mg/kg",1,102.1]
[null,null,2,66.8,null,null,2,117.1]
[null,null,3,49.6,null,null,3,133]
[null,null,4,49.5,null,null,4,128.9]
[null,null,5,57.9,null,null,5,117.5]

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[]
[null,"Supplementary Figure 2b: Survival rates of HPH"]
[null,"Survival rates","Control","Regora 8 μM"]
[null,"1st",100,42.35298]
[null,"2nd",100,12.03628]
[null,"3rd",100,62.00196]
[]
[null,"Supplementary Figure 2c: Survival rates of HL-7702"]
[null,null,"Regora for 24h",null,null,"Regora for 24h",null,null,"Regora for 24h"]
[null,"Concentration (μM)","Survival rates (%)","SD","N","Survival rates (%)","SD","N","Survival rates (%)","SD","N"]
[null,{"v":0,"d":"0.00"},{"v":100,"d":"100.00"},{"v":9.564355,"d":"9.56"},4,{"v":100,"d":"100.00"},{"v":1.916099,"d":"1.92"},4,{"v":100,"d":"100.00"},{"v":3.232037,"d":"3.23"},4]
[null,{"v":1,"d":"1.00"},{"v":96.03403,"d":"96.03"},{"v":5.153779,"d":"5.15"},4,{"v":96.20582,"d":"96.21"},{"v":1.543474,"d":"1.54"},4,{"v":97.60766,"d":"97.61"},{"v":2.965934,"d":"2.97"},4]
[null,{"v":2,"d":"2.00"},{"v":91.11965,"d":"91.12"},{"v":4.757706,"d":"4.76"},4,{"v":93.01806,"d":"93.02"},{"v":4.881165,"d":"4.88"},4,{"v":84.67491,"d":"84.67"},{"v":4.891866,"d":"4.89"},4]
[null,{"v":4,"d":"4.00"},{"v":68.97869,"d":"68.98"},{"v":2.96503,"d":"2.97"},4,{"v":48.2001,"d":"48.20"},{"v":5.409486,"d":"5.41"},4,{"v":26.27967,"d":"26.28"},{"v":2.780445,"d":"2.78"},4]
[null,{"v":8,"d":"8.00"},{"v":60.68636,"d":"60.69"},{"v":5.55677,"d":"5.56"},4,{"v":29.06909,"d":"29.07"},{"v":5.791111,"d":"5.79"},4,{"v":15.4317,"d":"15.43"},{"v":4.489076,"d":"4.49"},4]
[null,{"v":16,"d":"16.00"},{"v":53.95702,"d":"53.96"},{"v":6.993402,"d":"6.99"},4,{"v":24.05698,"d":"24.06"},{"v":6.085856,"d":"6.09"},4,{"v":13.86502,"d":"13.87"},{"v":6.420976,"d":"6.42"},4]
[]
[null,"Supplementary Figure 2d: c-PARP/GAPDH protein expression of HL-7702"]
[null,"Fold change","Regora (μM)",{"$nulls":5},"Fold change","Regora 8 μM (h)"]
[null,null,0,1,2,4,8,null,null,0,3,6,12,24]
[null,"1st",{"v":1,"d":"1.00"},{"v":1.4,"d":"1.40"},2.43,2.11,3.69,null,"1st",{"v":1,"d":"1.00"},{"v":1.231161,"d":"1.23"},{"v":1.526232,"d":"1.53"},{"v":4.442926,"d":"4.44"},{"v":4.301055,"d":"4.30"}]
[null,"2nd",{"v":1,"d":"1.00"},1.45,2.45,2.75,4.39,null,"2nd",{"v":1,"d":"1.00"},{"v":0.926795,"d":"0.93"},{"v":1.543223,"d":"1.54"},{"v":1.991831,"d":"1.99"},{"v":3.044167,"d":"3.04"}]
[null,"3rd",{"v":1,"d":"1.00"},1.08,2.15,2.26,3.66,null,"3rd",{"v":1,"d":"1.00"},{"v":0.996576,"d":"1.00"},{"v":1.522188,"d":"1.52"},{"v":2.604787,"d":"2.60"},{"v":4.313774,"d":"4.31"}]
{"$rows_empty":25}
[null,"Supplementary Figure 2e: Survival rates of HL-7702"]
[null,"Survival rates","Control","Regora","Z-VAD-FMK","Combinition"]
[null,"1st",{"v":100,"d":"100.00"},{"v":38.91591,"d":"38.92"},{"v":103.1408,"d":"103.14"},{"v":66.79993,"d":"66.80"}]
[null,"2nd",{"v":100,"d":"100.00"},{"v":37.98066,"d":"37.98"},{"v":107.3834,"d":"107.38"},{"v":68.17897,"d":"68.18"}]
[null,"3rd",{"v":100,"d":"100.00"},{"v":30.99159,"d":"30.99"},{"v":98.65993,"d":"98.66"},{"v":40.95237,"d":"40.95"}]
[]
[null,"Supplementary Figure 2f: c-PARP/GAPDH protein expression of HL-7702"]
[null,"Fold change","Control","Regora","Z-VAD-FMK","Combinition"]
[null,"1st",{"v":1,"d":"1.00"},{"v":8.549388,"d":"8.55"},{"v":1.684366,"d":"1.68"},{"v":6.569958,"d":"6.57"}]
[null,"2nd",{"v":1,"d":"1.00"},{"v":8.268345,"d":"8.27"},{"v":1.091945,"d":"1.09"},{"v":5.566482,"d":"5.57"}]
[null,"3rd",{"v":1,"d":"1.00"},{"v":8.692989,"d":"8.69"},{"v":1.602622,"d":"1.60"},{"v":3.384869,"d":"3.38"}]
{"$rows_empty":22}
[null,"Supplementary Figure 2g: Annexin V-FITC"]
[null,"Apoptosis rates","Control","Regora","Z-VAD-FMK","Combinition"]
[null,"1st",5.34,47.04,3.74,20.77]
[null,"2nd",4.72,53.85,3.74,{"v":19.3,"d":"19.30"}]
[null,"3rd",4.85,56.29,3.85,20.13]

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[]
[null,"Supplementary Figure 3a: IHC analysis (pY-ERK)"]
[null,"Fold change","No.","Inrensity (a.u.)"]
[null,"Vehicle",1,{"v":0.909091,"d":"0.91"}]
[null,null,2,{"v":1.090909,"d":"1.09"}]
[null,null,3,{"v":0.909091,"d":"0.91"}]
[null,null,4,{"v":1.090909,"d":"1.09"}]
[null,null,5,{"v":1,"d":"1.00"}]
[null,"Regora",1,{"v":2.727273,"d":"2.73"}]
[null,null,2,{"v":2.363636,"d":"2.36"}]
[null,null,3,{"v":2.181818,"d":"2.18"}]
[null,null,4,{"v":2.272727,"d":"2.27"}]
[null,null,5,{"v":2.454545,"d":"2.45"}]

{"sheet":"Supplementary Figure 4","index":38,"n_rows":41,"n_cols":12,"rows_kept":41,"merged":[[2,1,3,1],[2,2,2,6],[14,1,19,1],[20,1,25,1],[29,1,34,1],[35,1,40,1]],"flags":["formulas_cached_only"]}
[]
[null,"Supplementary Figure 4a: p53 gene expression of HL-7702",{"$nulls":7},"Supplementary Figure 4a: p53 gene expression of mice"]
[null,"Fold change","Regora (μM) ",{"$nulls":6},"NO.","Vehicle","Regora"]
[null,null,0,1,2,4,8,null,null,1,{"v":1.016116658,"d":"1.02"},{"v":1.344036505,"d":"1.34"}]
[null,"1st",{"v":1,"d":"1.00"},{"v":1.6869279378734436,"d":"1.69"},{"v":1.8776583661703292,"d":"1.88"},{"v":0.9763603224208605,"d":"0.98"},{"v":1.8086021548980655,"d":"1.81"},null,null,2,{"v":0.992650303,"d":"0.99"},{"v":0.619390985,"d":"0.62"}]
[null,"2nd",{"v":1,"d":"1.00"},{"v":0.4848973986123851,"d":"0.48"},{"v":1.0700025896861964,"d":"1.07"},{"v":0.7753447152710307,"d":"0.78"},{"v":1.2948359763674602,"d":"1.29"},null,null,3,{"v":1.09717042,"d":"1.10"},{"v":1.162701033,"d":"1.16"}]
[null,"3rd",{"v":1,"d":"1.00"},{"v":0.6588411744119886,"d":"0.66"},{"v":1.2130971619752695,"d":"1.21"},{"v":0.8632882610976343,"d":"0.86"},{"v":0.6046766294102693,"d":"0.60"},null,null,4,{"v":0.903620467,"d":"0.90"},{"v":1.064894245,"d":"1.06"}]
[{"$nulls":9},5,{"v":1.316178492,"d":"1.32"},{"v":1.645367686,"d":"1.65"}]
[{"$nulls":9},6,{"v":1.284423264,"d":"1.28"},{"v":0.779872516,"d":"0.78"}]
[{"$nulls":9},7,{"v":0.589592317,"d":"0.59"},{"v":1.033256738,"d":"1.03"}]
[{"$nulls":9},8,{"v":0.67524173,"d":"0.68"},{"v":0.705390851,"d":"0.71"}]
[]
[null,"Supplementary Figure 4b:  p53/GAPDH protein expression of HL-7702"]
[null,"Fold change","Time (min)","1st","2nd","3rd"]
[null,"CHX",0,{"v":1,"d":"1.00"},{"v":1,"d":"1.00"},{"v":1,"d":"1.00"}]
[null,null,15,{"v":0.559278,"d":"0.56"},{"v":0.516826,"d":"0.52"},{"v":0.417618,"d":"0.42"}]
[null,null,30,{"v":0.520162,"d":"0.52"},{"v":0.396202,"d":"0.40"},{"v":0.167175,"d":"0.17"}]
[null,null,45,{"v":0.380477,"d":"0.38"},{"v":0.224782,"d":"0.22"},{"v":0.123628,"d":"0.12"}]
[null,null,60,{"v":0.273062,"d":"0.27"},{"v":0.123138,"d":"0.12"},{"v":0.061986,"d":"0.06"}]
[null,null,90,{"v":0.287114,"d":"0.29"},{"v":0.055322,"d":"0.06"},{"v":0.048009,"d":"0.05"}]
[null,"CHX + Regora",0,{"v":1,"d":"1.00"},{"v":1,"d":"1.00"},{"v":1,"d":"1.00"}]
[null,null,15,{"v":0.588259,"d":"0.59"},{"v":0.82773,"d":"0.83"},{"v":0.863362,"d":"0.86"}]
[null,null,30,{"v":0.630356,"d":"0.63"},{"v":0.93164,"d":"0.93"},{"v":0.803002,"d":"0.80"}]
[null,null,45,{"v":0.568644,"d":"0.57"},{"v":0.586704,"d":"0.59"},{"v":0.746881,"d":"0.75"}]
[null,null,60,{"v":0.543298,"d":"0.54"},{"v":0.408313,"d":"0.41"},{"v":0.428318,"d":"0.43"}]
[null,null,90,{"v":0.538441,"d":"0.54"},{"v":0.055419,"d":"0.06"},{"v":0.405559,"d":"0.41"}]
[]
[null,"Supplementary Figure 4c:  p53/GAPDH protein expression of HL-7702"]
[null,"Fold change","Time (min)"]
[null,"MG132",0,{"v":1,"d":"1.00"}]
[null,null,15,{"v":2.150073,"d":"2.15"}]
[null,null,30,{"v":4.010612,"d":"4.01"}]
[null,null,45,{"v":6.476364,"d":"6.48"}]
[null,null,60,{"v":5.861564,"d":"5.86"}]
[null,null,90,{"v":5.768185,"d":"5.77"}]
[null,"MG132 + Regora",0,{"v":1,"d":"1.00"}]
[null,null,15,{"v":2.469864,"d":"2.47"}]
[null,null,30,{"v":4.438946,"d":"4.44"}]
[null,null,45,{"v":4.974899,"d":"4.97"}]
[null,null,60,{"v":6.741647,"d":"6.74"}]
[null,null,90,{"v":6.873132,"d":"6.87"}]

{"sheet":"Supplementary Figure 5","index":39,"n_rows":45,"n_cols":10,"rows_kept":45,"merged":[[3,2,3,4],[3,5,3,7],[13,2,13,4],[13,5,13,7],[22,1,23,1],[22,2,22,4],[22,5,22,7],[39,1,40,1],[39,2,39,3],[39,4,39,5],[39,6,39,7],[39,8,39,9]],"flags":["formulas_cached_only"]}
[]
[null,"Supplementary Figure 5a: Survival rates of HL-7702"]
[null,"Survival rates (%)","1st","2nd","3rd","1st","2nd","3rd"]
[null,"Cmax","Regora",null,null,"Sora"]
[null,0,{"v":100,"d":"100.00"},{"v":100,"d":"100.00"},{"v":100,"d":"100.00"},{"v":100,"d":"100.00"},{"v":100,"d":"100.00"},{"v":100,"d":"100.00"}]
[null,0.125,{"v":103.4874,"d":"103.49"},{"v":94.75056,"d":"94.75"},{"v":102.9403,"d":"102.94"},{"v":109.148,"d":"109.15"},{"v":98.46208,"d":"98.46"},{"v":95.2919,"d":"95.29"}]
[null,0.25,{"v":100.3178,"d":"100.32"},{"v":92.07898,"d":"92.08"},{"v":95.67044,"d":"95.67"},{"v":99.79167,"d":"99.79"},{"v":94.9439,"d":"94.94"},{"v":88.51792,"d":"88.52"}]
[null,0.5,{"v":89.17017,"d":"89.17"},{"v":79.70531,"d":"79.71"},{"v":82.10544,"d":"82.11"},{"v":97.15865,"d":"97.16"},{"v":97.88206,"d":"97.88"},{"v":82.09787,"d":"82.10"}]
[null,1,{"v":64.12098,"d":"64.12"},{"v":64.80944,"d":"64.81"},{"v":44.8438,"d":"44.84"},{"v":94.30731,"d":"94.31"},{"v":92.161,"d":"92.16"},{"v":80.12946,"d":"80.13"}]
[null,2,{"v":28.29246,"d":"28.29"},{"v":24.84108,"d":"24.84"},{"v":26.74957,"d":"26.75"},{"v":52.38944,"d":"52.39"},{"v":65.54765,"d":"65.55"},{"v":55.63221,"d":"55.63"}]
{"$rows_empty":11}
[null,"Supplementary Figure 5c: Survival rates of HL-7702"]
[null,"Survival rates (%)","DMSO",null,null,"Regora"]
[null,null,"Mean","SD","N","Mean","SD","N"]
[null,"NC",{"v":100,"d":"100.00"},{"v":2.780143,"d":"2.78"},3,{"v":44.95968,"d":"44.96"},{"v":1.624946,"d":"1.62"},3]
[null,"siKIT",{"v":102.3135,"d":"102.31"},{"v":2.97304,"d":"2.97"},3,{"v":43.89588,"d":"43.90"},{"v":2.640544,"d":"2.64"},3]
[null,"siEphA2",{"v":104.1209,"d":"104.12"},{"v":1.627503,"d":"1.63"},3,{"v":74.07917,"d":"74.08"},{"v":4.496993,"d":"4.50"},3]
[null,"siTrkA",{"v":101.5778,"d":"101.58"},{"v":1.977901,"d":"1.98"},3,{"v":45.01345,"d":"45.01"},{"v":4.828836,"d":"4.83"},3]
[null,"siSAPK2",{"v":97.66149,"d":"97.66"},{"v":0.348331,"d":"0.35"},3,{"v":43.60942,"d":"43.61"},{"v":0.817865,"d":"0.82"},3]
[null,"siPTK",{"v":94.81803,"d":"94.82"},{"v":2.147448,"d":"2.15"},3,{"v":40.62876,"d":"40.63"},{"v":1.117069,"d":"1.12"},3]
[null,"siDDR2",{"v":96.8243,"d":"96.82"},{"v":3.147448,"d":"3.15"},3,{"v":44.62876,"d":"44.63"},{"v":1.238,"d":"1.24"},3]
[]
[null,"Supplementary Figure 5d: Annexin V-FITC"]
[null,"Apoptosis rates (%) ","NC","NC + Regora","siEphA2","siEphA2+Regora"]
[null,"1st",4.05,47.04,4.62,38.87]
[null,"2nd",4.51,57.76,5.35,46.56]
[null,"3rd",3.32,47.66,3.2,38.03]
[]
[null,"Supplementary Figure 5e: JC-1"]
[null,null,"1st",null,"2nd",null,"3rd",null,"4th"]
[null,null,"Red positive cell (%)","Green positive cell (%)","Red positive cell (%)","Green positive cell (%)","Red positive cell (%)","Green positive cell (%)","Red positive cell (%)","Green positive cell (%)"]
[null,"NC",96.91,97.81,90.1,91.34,3.11,2.21,10.05,8.98]
[null,"NC+Regora",12.09,16.88,26.42,19.51,85.07,85.17,73.95,80.17]
[null,"siEphA2",90.96,91.71,91.31,94.14,9.01,8.33,8.85,6.21]
[null,"siEphA2+ Regora",87.7,89.65,74.32,65.46,11.01,11.04,26,34.97]

{"sheet":"Supplementary Figure 7","index":40,"n_rows":9,"n_cols":4,"rows_kept":9,"flags":["formulas_cached_only"]}
[]
[null,"Supplementary Figure 7c:  pS-EphA2/GAPDH protein expression of mice"]
[null,"NO.","Vehicle","Regora"]
[null,1,{"v":2.014337362268317,"d":"2.01"},{"v":0.4810803371978677,"d":"0.48"}]
[null,2,{"v":0.6364538228562003,"d":"0.64"},{"v":0.4191684721097549,"d":"0.42"}]
[null,3,{"v":1.2118151285670458,"d":"1.21"},{"v":0.24216319162126818,"d":"0.24"}]
[null,4,{"v":0.819741957929577,"d":"0.82"},{"v":0.21918157090245532,"d":"0.22"}]
[null,5,{"v":0.7252235516669379,"d":"0.73"},{"v":0.45260896476199974,"d":"0.45"}]
[null,6,{"v":0.5924281767119224,"d":"0.59"},{"v":0.27646825461020463,"d":"0.28"}]

{"sheet":"Supplementary Figure 8","index":41,"n_rows":28,"n_cols":11,"rows_kept":28,"merged":[[2,1,3,1],[2,2,2,4],[2,5,2,7],[2,8,2,10],[9,1,10,1],[9,2,9,4],[9,5,9,7],[9,8,9,10],[17,1,18,1],[17,2,18,2],[17,3,17,4],[17,5,17,6],[17,7,17,8],[17,9,17,10],[19,1,21,1],[22,1,24,1],[25,1,27,1]],"flags":["formulas_cached_only"]}
[]
[null,"Supplementary Figure 8a:  Survival rates of HL-7702"]
[null,"Survival rates (%)","Vector (μg)",null,null,"EphA2-S897A (μg)",null,null,"EphA2-S897D (μg)"]
[null,null,0.5,1,1.5,0.5,1,1.5,0.5,1,1.5]
[null,"1st",{"v":100,"d":"100.00"},{"v":102.9582,"d":"102.96"},{"v":92.09327,"d":"92.09"},{"v":48.65761,"d":"48.66"},{"v":25.66508,"d":"25.67"},{"v":24.20666,"d":"24.21"},{"v":102.1363,"d":"102.14"},{"v":101.396,"d":"101.40"},{"v":98.80197,"d":"98.80"}]
[null,"2nd",{"v":100,"d":"100.00"},{"v":106.2245,"d":"106.22"},{"v":101.0799,"d":"101.08"},{"v":45.31054,"d":"45.31"},{"v":26.48337,"d":"26.48"},{"v":25.257,"d":"25.26"},{"v":104.6731,"d":"104.67"},{"v":108.3916,"d":"108.39"},{"v":110.2422,"d":"110.24"}]
[null,"3rd",{"v":100,"d":"100.00"},{"v":94.90303,"d":"94.90"},{"v":92.92891,"d":"92.93"},{"v":47.95163,"d":"47.95"},{"v":24.32904,"d":"24.33"},{"v":23.63865,"d":"23.64"},{"v":99.03705,"d":"99.04"},{"v":102.0275,"d":"102.03"},{"v":99.37517,"d":"99.38"}]
[]
[null,"Supplementary Figure 8b: Annexin V-FITC"]
[null,"Apoptosis rates (%)","Vector (μg)",null,null,"EphA2-S897A (μg)",null,null,"EphA2-S897D (μg)"]
[null,null,0.5,1,1.5,0.5,1,1.5,0.5,1,1.5]
[null,"1st",6.9,6.1,6.5,8.3,20.1,{"v":31,"d":"31.0"},6.4,7.2,9.2]
[null,"2nd",5.2,7.5,6.5,20.5,20.5,30.6,12.9,10.9,8.9]
[null,"3rd",{"v":6,"d":"6.0"},10.1,12.6,18.6,19.7,{"v":27,"d":"27.0"},7.8,12.6,20.4]
[null,"4th",{"v":5.75,"d":"5.8"},{"v":6.17,"d":"6.2"},{"v":11.38,"d":"11.4"},{"v":22.02,"d":"22.0"},{"v":36.67,"d":"36.7"},{"v":36.92,"d":"36.9"},{"v":8.48,"d":"8.5"},{"v":9.47,"d":"9.5"},{"v":11.23,"d":"11.2"}]
[]
[null,"Supplementary Figure 8c: JC-1"]
[{"$nulls":3},"1st",null,"2nd",null,"3rd",null,"4th"]
[{"$nulls":3},"Red positive cell (%)","Green positive cell (%)","Red positive cell (%)","Green positive cell (%)","Red positive cell (%)","Green positive cell (%)","Red positive cell (%)","Green positive cell (%)"]
[null,"Vector (μg)",0.5,84.1,16.1,86.4,13.7,88.1,12.5,{"v":84.01,"d":"84.0"},15.2]
[null,null,1,88.9,11.2,87.2,12.7,84.7,15.6,{"v":84.45,"d":"84.5"},14.7]
[null,null,1.5,86.9,13.1,85.6,14.4,82.4,18.2,{"v":84.17,"d":"84.2"},{"v":15.04,"d":"15.0"}]
[null,"EphA2-S897A (μg)",0.5,86.4,13.5,86.3,13.7,80.2,20.3,{"v":84.15,"d":"84.2"},{"v":14.79,"d":"14.8"}]
[null,null,1,72.6,27.2,68.1,32.1,79.1,21.5,{"v":71.49,"d":"71.5"},{"v":24.88,"d":"24.9"}]
[null,null,1.5,67.1,32.8,65.8,34.2,71.2,29.8,{"v":47.63,"d":"47.6"},{"v":51.53,"d":"51.5"}]
[null,"EphA2-S897D (μg)",0.5,84.5,15.5,{"v":87,"d":"87.0"},13.4,86.4,13.6,{"v":82.05,"d":"82.1"},{"v":17.23,"d":"17.2"}]
[null,null,1,84.5,15.6,80.1,20.5,81.2,18.6,{"v":81.93,"d":"81.9"},{"v":17.32,"d":"17.3"}]
[null,null,1.5,86.7,13.3,89.8,10.5,83.4,16.6,{"v":80.36,"d":"80.4"},{"v":18.84,"d":"18.8"}]

{"sheet":"Supplementary Figure 9","index":42,"n_rows":0,"n_cols":0,"rows_kept":0,"flags":["formulas_cached_only"]}

{"sheet":"Supplementary Figure 10","index":43,"n_rows":0,"n_cols":0,"rows_kept":0,"flags":["formulas_cached_only"]}

{"sheet":"Supplementary Figure 11","index":44,"n_rows":16,"n_cols":4,"rows_kept":16,"flags":["formulas_cached_only"]}
[]
[null,"Supplementary Figure 11:  pS-MDM2/GAPDH protein expression of mice"]
[null,"NO.","Vehicle","Regora"]
[null,1,{"v":1.101849560034183,"d":"1.10"},{"v":0.900779249435399,"d":"0.90"}]
[null,2,{"v":0.8364368775668265,"d":"0.84"},{"v":0.968745,"d":"0.97"}]
[null,3,{"v":0.7597493919866701,"d":"0.76"},{"v":0.4545575695951456,"d":"0.45"}]
[null,4,{"v":1.1963801859170724,"d":"1.20"},{"v":0.294380321196108,"d":"0.29"}]
[null,5,{"v":1.1055839844952473,"d":"1.11"},{"v":0.2110327489562419,"d":"0.21"}]
[]
[null,"Supplementary Figure 11:  p53/GAPDH protein expression of mice"]
[null,"NO.","Vehicle","Regora"]
[null,1,{"v":0.37604286468103226,"d":"0.38"},{"v":7.814956088379672,"d":"7.81"}]
[null,2,{"v":0.6345447991538498,"d":"0.63"},{"v":10.384606070601256,"d":"10.38"}]
[null,3,{"v":0.5379586464459543,"d":"0.54"},{"v":3.872299826024154,"d":"3.87"}]
[null,4,{"v":1.1582453741327223,"d":"1.16"},{"v":6.098549488169566,"d":"6.10"}]
[null,5,{"v":2.293208315586441,"d":"2.29"},{"v":13.130748514866916,"d":"13.13"}]

{"sheet":"Supplementary Figure 13","index":45,"n_rows":0,"n_cols":0,"rows_kept":0,"flags":["formulas_cached_only"]}

{"sheet":"Supplementary Figure 14","index":46,"n_rows":0,"n_cols":0,"rows_kept":0,"flags":["formulas_cached_only"]}

{"sheet":"Supplementary Figure 16","index":47,"n_rows":14,"n_cols":10,"rows_kept":14,"merged":[[1,1,1,3],[8,1,9,1],[8,2,8,3],[8,4,8,5],[8,6,8,7],[8,8,8,9]],"flags":["formulas_cached_only"]}
[]
[null,"Supplementary Figure 16a: Annexin V-FITC"]
[null,"Apoptosis rates","Control","Regora","Schi C","Combinition"]
[null,"1st",4.59,44.46,3.84,{"v":24.5,"d":"24.50"}]
[null,"2nd",5.06,49.69,4.18,34.55]
[null,"3rd",4.44,52.06,11.59,41.17]
[]
[null,"Supplementary Figure 16b: JC-1"]
[null,null,"1st",null,"2nd",null,"3rd",null,"4th"]
[null,null,"Red positive cell (%)","Green positive cell (%)","Red positive cell (%)","Green positive cell (%)","Red positive cell (%)","Green positive cell (%)","Red positive cell (%)","Green positive cell (%)"]
[null,"Control",92.75,7.27,93.29,6.81,94.38,5.77,{"v":95.1,"d":"95.10"},5.09]
[null,"Regora",14.99,81.79,20.28,81.99,17.53,82.79,22.86,76.47]
[null,"Schi C",97.72,2.23,97.88,2.09,94.75,5.34,89.46,10.88]
[null,"Combinition",83.04,15.22,85.73,15.28,75.17,25.29,67.33,33.21]

{"sheet":"Supplementary Figure 17","index":48,"n_rows":0,"n_cols":0,"rows_kept":0,"flags":["formulas_cached_only"]}

{"sheet":"Supplementary Figure 18","index":49,"n_rows":8,"n_cols":6,"rows_kept":8,"flags":["formulas_cached_only"]}
[]
[null,"Supplementary Figure 18：LW/BW (%)"]
[null,"NO.","Vehicle","Regora","Schi C","Combinition"]
[null,1,{"v":3.692575,"d":"3.69"},{"v":4.938438,"d":"4.94"},{"v":3.781553,"d":"3.78"},{"v":3.91784,"d":"3.92"}]
[null,2,{"v":3.717437,"d":"3.72"},{"v":4.763427,"d":"4.76"},{"v":3.945581,"d":"3.95"},{"v":4.042672,"d":"4.04"}]
[null,3,{"v":3.82286,"d":"3.82"},{"v":4.75852,"d":"4.76"},{"v":3.907723,"d":"3.91"},{"v":3.878926,"d":"3.88"}]
[null,4,{"v":3.697141,"d":"3.70"},{"v":4.92439,"d":"4.92"},{"v":3.894677,"d":"3.89"},{"v":3.856693,"d":"3.86"}]
[null,5,{"v":3.79305,"d":"3.79"},{"v":4.929561,"d":"4.93"},{"v":3.878104,"d":"3.88"},{"v":3.82792,"d":"3.83"}]

{"sheet":"Supplementary Figure 19","index":50,"n_rows":27,"n_cols":6,"rows_kept":27,"flags":["formulas_cached_only"]}
[]
[null,"Supplementary Figure 19"]
[null,"Survival rates of Bel-7402"]
[null,"Survival rates (%)","Control","Regora","Schi C","Combinition"]
[null,"1st",{"v":100,"d":"100.00"},{"v":42.7051,"d":"42.71"},{"v":98.49637,"d":"98.50"},{"v":42.86939,"d":"42.87"}]
[null,"2nd",{"v":100,"d":"100.00"},{"v":42.81498,"d":"42.81"},{"v":100.8457,"d":"100.85"},{"v":42.05883,"d":"42.06"}]
[null,"3rd",{"v":100,"d":"100.00"},{"v":29.40806,"d":"29.41"},{"v":99.98064,"d":"99.98"},{"v":29.89691,"d":"29.90"}]
[]
[null,"Survival rates of Hep-G2"]
[null,"Survival rates (%)","Control","Regora","Schi C","Combinition"]
[null,"1st",{"v":100,"d":"100.00"},{"v":47.53673,"d":"47.54"},{"v":100.7923,"d":"100.79"},{"v":46.39513,"d":"46.40"}]
[null,"2nd",{"v":100,"d":"100.00"},{"v":42.7051,"d":"42.71"},{"v":98.49637,"d":"98.50"},{"v":42.86939,"d":"42.87"}]
[null,"3rd",{"v":100,"d":"100.00"},{"v":42.81498,"d":"42.81"},{"v":100.8457,"d":"100.85"},{"v":42.05883,"d":"42.06"}]
[]
[]
[null,"Survival rates of HCT-116"]
[null,"Survival rates (%)","Control","Regora","Schi C","Combinition"]
[null,"1st",{"v":100,"d":"100.00"},{"v":20.02575,"d":"20.03"},{"v":52.19134,"d":"52.19"},{"v":15.01628,"d":"15.02"}]
[null,"2nd",{"v":100,"d":"100.00"},{"v":21.9081,"d":"21.91"},{"v":56.85196,"d":"56.85"},{"v":15.82883,"d":"15.83"}]
[null,"3rd",{"v":100,"d":"100.00"},{"v":25.4228,"d":"25.42"},{"v":58.55601,"d":"58.56"},{"v":17.76535,"d":"17.77"}]
[]
[]
[null,"Survival rates of SW-480"]
[null,"Survival rates (%)","Control","Regora","Schi C","Combinition"]
[null,"1st",{"v":100,"d":"100.00"},{"v":18.38142,"d":"18.38"},{"v":44.02815,"d":"44.03"},{"v":13.59606,"d":"13.60"}]
[null,"2nd",{"v":100,"d":"100.00"},{"v":17.90303,"d":"17.90"},{"v":39.26332,"d":"39.26"},{"v":13.08206,"d":"13.08"}]
[null,"3rd",{"v":100,"d":"100.00"},{"v":21.11209,"d":"21.11"},{"v":46.03111,"d":"46.03"},{"v":15.31872,"d":"15.32"}]