{"text_format":"3","workbook":"xlsx","n_sheets":7,"sheets":["S2A. CDE genes","S2B. p53 hypergeometric test","S2C. KRAS hypergeometric test","S2D. p53 GSEA","S2E. KRAS GSEA","S2F. Lof.p53 CDE genes","S2G. Lof.p53 CDE and pathway"],"read":"whole","date_system":"1900"}

{"sheet":"S2A. CDE genes","index":0,"n_rows":872,"n_cols":6,"rows_kept":872}
["S2A. CDE+/- genes of the two CCD genes."]
[]
["p53 CDE+","p53 CDE-","KRAS CDE+","KRAS CDE-",null,"Overlap between the CDE+ genes of p53 and KRAS:"]
["TAF8","CDKN1A","GREM2","ID1",null,"CR1"]
["FAF1","SLC4A8","GUCA2B","SLC6A12",null,"FN1"]
["HSPA14","MS4A1","HDAC1","TAF13",null,"MGST2"]
["OR2T35","TAP2","INSIG1","ELF2",null,"MAP2K2"]
["UCHL3","CCDC51","KRTAP10-10","CCDC58",null,"HOXA9"]
["QRICH1","OMP","TSC22D4","ERGIC2",null,"CD83"]
["UBFD1","FAM181B","TSPAN32","ERP44",null,"TBC1D10B"]
["TERF1","GINS4","ATOH8","FILIP1L",null,"SOX6"]
["SPTY2D1","GRIA2","RD3","GLG1",null,"AGXT"]
["THUMPD1","IL23R","GSTM1","RFWD3",null,"CLPP"]
["EHMT1","PAM","KRTAP4-12","C14orf28",null,"SOCS1"]
["SRI","PSMB2","IFI6","LIG4",null,"DUOX1"]
["NCL","ZNF664","NAGK","NOSTRIN",null,"CRYGN"]
["KNTC1","DEPDC1B","GRPEL2","DCT",null,"GBE1"]
["TAF1D","LILRB3","CR1","DNAJC5B"]
["KIAA1524","PPP2R5A","EMX2","NT5C3A"]
["KRTAP19-3","SLC2A4","KIF17","RNF17"]
["RAB26","ATE1","MAPK9","TMCO3"]
["BRIP1","MCM6","RPL15","ZNF12"]
["SLC31A1","NFIX","OPRD1","PIGB"]
["STAT5A","POLR3B","BAIAP2L2","SFR1"]
["WRN","TBCD","ALOX5AP","CEP89"]
["DDX31","ZNF44","BOK","ERMN"]
["WDR74","C9orf3","FAM216A","PARP8"]
["ZNF668","ESCO1","RRAS2","SEMG2"]
["CDAN1","KCNJ16","RSPO1","IGSF10"]
["NTAN1","RAPGEF3","TACSTD2","BMF"]
["EEF1D","TRPS1","KISS1","CCDC178"]
["URGCP","FBXO42","C5orf52","GNPNAT1"]
["CYP2A13","DHX15","LRRTM1","GOLGA8M"]
["DAZAP1","NSF","AMPD2","MAP3K2"]
["GRIN2A","CSH1","EPHB4","TAS2R13"]
["HEATR1","CCT3","HIST3H2A","ZNF205"]
["MZF1","E2F7","ELAVL4","ZNF730"]
["EXO1","CX3CR1","CDKN1C","DUOXA2"]
["BRAP","ISCU","LAMA4","CDX2"]
["OR2T2","KERA","NUP210","GNPDA2"]
["PDXK","KRT40","PCGF1","SLC16A12"]
["PAPOLA","SLC10A2","PDE4B","CYLD"]
["ZWILCH","SULT1C4","PRSS57","PLCB4"]
["HIST1H4K","C1QL2","C6orf223","ZNF253"]
["CEP295","ITGB7","FN1","PROSER1"]
["NDUFA5","MTBP","NPTX2","TSTA3"]
["C11orf58","DNAJC18","RIMS3","ACTL7A"]
["ARHGEF5","GPD1","RCN2","BMPR1A"]
["CASKIN1","RBM33","AP2A2","CLEC12A"]
["NDUFB6","RGPD4","TMEM173","FMNL1"]
["RBM34","STXBP3","FAM71F1","KIF3B"]
["SLC27A5","CCDC122","IRX1","LEO1"]
["SURF2","MFSD5","TCF15","PDPR"]
["WDR75","SORBS1","AGAP3","TMSB10"]
["ZNF425","XAB2","FCAR","TRAF7"]
["ZNF417","CCSER2","KCNAB1","YEATS2"]
["NAF1","RAD52","LHCGR","ZDHHC19"]
["PSME3","POLR3F","IGFBP2","ZNF705A"]
["RAB40B","YIPF1","CLDN23","COX6A2"]
["NDUFC1","POLR2G","DLG2","TPTE2"]
["RPS3","ANAPC10","PLXNB2","ZNF519"]
["SRFBP1","ZNF331","GADD45A","CFLAR"]
["FDX1","NAPA","FBXO2","XYLT1"]
["MSRB1","ANAPC11","NR1I2","KIF16B"]
["OR2T33","EIF3C","MYOZ3","UROD"]
["SERF2","PPP1R3C","CDHR2","FARP1"]
["DDX21","CCDC6","GJA4","BORA"]
["AGBL3","TMEM19","ARHGEF1","TF"]
["FGFR1OP","PELI1","FRS2","EPHA3"]
["PSPC1","DYNC1I2","GAD2","HADHA"]
["LPA","PHF5A","MGST2","2018-03-08"]
["YWHAE","RSF1","RUFY2","TATDN1"]
["CACYBP","VPS4B","IDUA","ZNF654"]
["CPNE7","AGTPBP1","DEDD2","GNG13"]
["FTCD","FRMD3","PLEKHA4","CSGALNACT2"]
["GAR1","HRH2","NPAS2","LATS1"]
["GPATCH2","OR10Z1","CYP2D6","OLFM4"]
["HIST1H2AB","POLR3G","DYNC2H1","UGT2B7"]
["IFNA4","SEC13","PTGIR","CCDC113"]
["PRRC2C","UBE2E2","KLHL21","SLC9B1"]
["RPL27A","DMGDH","CELA3B","CPNE3"]
["TRMT1L","FAM49A","HIVEP1","ITGAM"]
["WDR48","FRS2","GRIN1","CBLN1"]
["ZNF688","FADS1","PANX2","CCDC25"]
["TAF3","OR2T4","PNPLA5","SDHC"]
["FANCG","SLC16A10","ABL2","CCNT2"]
["NDUFA2","PTPRC","ANKRD37","HLA-C"]
["CCP110","KLHDC7A","ASAP2","IL12RB2"]
["CDH15","KRT20","EVPL","ENTHD1"]
["CCNG1","LMAN1","FHL3","SMG5"]
["DBNDD1","PAH","FOXE3","ACRBP"]
["DUSP22","PCDHGB7","GCDH","BLK"]
["GBA2","PTPRK","GH1","SENP6"]
["H2AFX","SLC22A11","MYCN","USF2"]
["MAPRE1","SLC7A4","MYOG","KMT2B"]
["POP7","USP49","UBALD2","TTF1"]
["LANCL1","GINS1","APOPT1","ZKSCAN2"]
["CPED1","IL37","C5orf46","SERPINB7"]
["DNAJA1","NOD2","TMPRSS9","ST3GAL6"]
["NMRAL1","TOM1L2","LRP10","AREL1"]
["ZNHIT6","ATP8B4","NAPA","CPQ"]
["BAIAP3","CARS","MXRA8","GRB10"]
["NDUFB8","CCDC167","ANKRD53","LCN8"]
["COMMD8","FOSL1","ATXN7L2","SARNP"]
["ZNF705A","GTF2H2","CYR61","TTC14"]
["MAZ","GTF2H2C","LRRFIP1","SPOPL"]
["NDUFB10","KRT39","POU4F2","TP53I3"]
["ZBTB45","MAPK9","REG3A","NANP"]
["RPL36AL","MBD3L1","MAP2K2","BPIFB3"]
["ZNF771","MDGA2","CCNG2","KBTBD12"]
["TWISTNB","OMD","CYB5R1","ARHGAP31"]
["HIST1H1D","SMCO3","HSBP1L1","MYO10"]
["COX5A","ULK4","LMX1A","SURF6"]
["NDUFS2","VPS4A","PIP5K1B","ADAM32"]
["RRAGA","CSNK2A2","PLA2R1","BCAR1"]
["SLC25A3","HSPA2","ASB1","CCDC180"]
["RP1L1","LRRC7","ULK4","KAT8"]
["OR3A3","LUM","DBNDD2","PRR3"]
["TNFRSF12A","C10orf120","NRGN","SLC1A2"]
["COX17","GREB1L","RAI1","STIM1"]
["CSH2","ODAM","MYCL","STX8"]
["NDUFAF1","REG4","PDLIM5","TMTC1"]
["MEF2A","CRISPLD1","PRM2","ZNF75A"]
["PKD1","KRT34","SPDEF","CAMKK2"]
["CCNL1","NT5DC3","DEGS1","FAM207A"]
["USP38","EHBP1","GMCL1","HORMAD1"]
["RPL6","SH2B3","PPP1R3G","MIA2"]
["ZNF587","GUK1","PRKCH","OR1A1"]
["KRTAP4-4","ELOVL7","RNF135","TASP1"]
["FBXL6","DBNDD2","CGREF1","FGF9"]
["NOM1","DAPK1","LRP11","PKNOX1"]
["MPLKIP","AMPD2","NOG","B4GALT4"]
["LIPT1","NKD1","PDZRN3","CA8"]
["RPS8","SNAPC4","SPAST","DNAH9"]
["GATAD2A","HIGD1B","TMEM207","IMPDH2"]
["NEDD4L","ASCC2","TMEM65","IYD"]
["CHTF18","LZTS2","MAPK8IP1","GZMH"]
["NELFA","RFESD","PTGER1","C3orf56"]
["RPL27","UBE2K","TMEM14C","CPD"]
["ULBP2","NEUROD4","A1CF","NPM1"]
["ERCC6L2","LSM7","SSUH2","YPEL4"]
["TTC14","USP44","TTC12","IL17RE"]
["APOC1","LLGL1","MAGOHB","COCH"]
["CTDSP2","PCDHB1","ABTB2","NSMAF"]
["ANKRD49","UBA6","GIPC1","DDX52"]
["EIF4EBP1","RAP1GAP2","EFNA3","SND1"]
["FANCA","FUBP3","GBX2","TAL2"]
["HIST1H4E","GOLT1A","HTR1A","SDHAF2"]
["ORAI3","ZBTB26","OBSCN","GYS2"]
["IFNA1","ZC3H6","PURB","DPPA2"]
["PAGR1","ACVR1B","SOX1","RCBTB2"]
["ZMYND8","AFM","FEM1B","UBA2"]
["COQ4","AREG","AMDHD1","ADPRH"]
["ZDHHC2","CYP27C1","ATAD3A","ATRN"]
["GDE1","CYSTM1","BST1","C14orf119"]
["DEFB4A","GAL3ST3","FLNC","FNBP4"]
["YY1","GKN2","RNF144A","DHODH"]
["PIGX","KCNAB2","SCARF1","KCNRG"]
["ZNF695","MUT","SLC35B4","LYN"]
["RPL34","NARS","TCTA","TBPL2"]
["PRSS3","NCOA7","ZNF534","WFDC9"]
["CWF19L2","SACM1L","ARHGAP10","LENG8"]
["FLT3LG","SPTB","OR51D1","TIPARP"]
["POLE4","ST3GAL5","PNMA1","HELLS"]
["ZC3H3","TMEM117","ARFGAP3","ARID3C"]
["RPL23","ZFP2","S1PR3","RAP1B"]
["FNTB","ZNF2","NEUROG1","NEK5"]
["VCPKMT","GOLGA8O","F2RL3","ATAD5"]
["ZNF277","HAL","HSPB1","MMAA"]
["STRA8","UBL5","RIMKLA","CDH5"]
["AGXT","DDAH2","MSRA","PLEKHA5"]
["GPC6","GPX3","TMEM246","RFC4"]
["PDSS2","TUBAL3","MYOD1","RDM1"]
["KRTAP4-2","CHRM1","CBLN2","SDHD"]
["SDCBP","ANKRD28","TRIM24","WFDC3"]
["MINOS1","HIF1A","ACSBG1","CD48"]
["PWP1","TAS2R42","OSR1","ZBTB3"]
["CHMP4C","LPXN","TBC1D26","XRCC2"]
["NDUFA8","CCNB1","TMEM236","FAM105A"]
["CGB5","FBXO38","DRAXIN","SAR1B"]
["BUD13","POTEE","KDM2B","ZNF232"]
["RPF1","COLEC10","KLF2","NUDCD3"]
["ZW10","IL18RAP","PNP","DYNLL1"]
["OR2C3","MCHR2","YTHDC2","CMTM2"]
["AAMP","TNFRSF11B","UTF1","NDUFAF5"]
["ANKRD17","DYSF","ZNF57","SLC6A6"]
["PIM3","EIF4A3","CLEC3B","NUP93"]
["PON1","ALDH4A1","GLIS1","CRLS1"]
["SDHD",null,"OR2D3","CTSA"]
["ZNF574",null,"RAB38","ARL2BP"]
["CHRAC1",null,"RHOV","BLOC1S2"]
["CR1",null,"CDR2L","DSTN"]
["ZG16",null,"ADM","KLRG1"]
["BCL2L12",null,"ADPRHL2","KRT28"]
["PPP4R2",null,"FZD9","MAP2K5"]
["PRAMEF6",null,"MPP4","NKX2-5"]
["KTI12",null,"TFAP2E","AMN1"]
["OR2L5",null,"EN1","SLC32A1"]
["POLR1E",null,"GALR2","ZUFSP"]
["SPHK2",null,"TFF2","ADAT1"]
["APTX",null,"CYSTM1","DMXL2"]
["ATP5I",null,"DGUOK","ELOVL3"]
["CCNT1",null,"LRRC71","FABP4"]
["NLRP13",null,"PRTN3","FGG"]
["KIAA0513",null,"CRYAA","KRTAP4-2"]
["FAM57B",null,"MIXL1","POP1"]
["ITSN2",null,"PTK6","PREX1"]
["SETD1A",null,"CAPN2","SEPT11"]
["EFCAB2",null,"FABP2","TMEM19"]
["CDK5",null,"RFX4","TMX2"]
["C20orf24",null,"SNAP47","TRIM49C"]
["PHKG1",null,"EOGT","DYNC2LI1"]
["MORF4L1",null,"NFE2L1","VPS39"]
["RPS27A",null,"CDK7","CDKL3"]
["TIMMDC1",null,"TP63","ICAM3"]
["DRAP1",null,"CALU","RRBP1"]
["INPP4B",null,"CCSER2","RAF1"]
["PDSS1",null,"GOLGA8O","CHRAC1"]
["TPSAB1",null,"HOXA9","FAM91A1"]
["C8orf33",null,"LEPROT","TFAP2D"]
["PTMA",null,"VWA1","THOC5"]
["MAML1",null,"CALHM1","ZNF91"]
["RDX",null,"FBXO44","WFDC12"]
["SAA2",null,"PAAF1","CYP1A2"]
["VWA8",null,"CD83","PTH"]
["CPSF4",null,"DMRT2","YWHAZ"]
["PAQR4",null,"MUC17","PKP2"]
["MRPL3",null,"TMEM182","SLC16A9"]
["ADAP1",null,"SLC26A9","KXD1"]
["AZIN1",null,"BRD3","FOXC2"]
["COL9A3",null,"FAM104A","KLHDC4"]
["XCL1",null,"NLRP14","PAK1"]
["CXCL2",null,"NPHS2","TIGD7"]
["TMEM8A",null,"PRAMEF1","ZNF195"]
["FUS",null,"RBP1","KRTAP9-2"]
["KRTAP10-9",null,"TSPYL6","OSTC"]
["IFNA17",null,"ADAMTS20","GRID2"]
["ABT1",null,"ALDH8A1","DEFB132"]
["INPP5E",null,"CALCA","NCALD"]
["MRGPRX1",null,"LSS","NMD3"]
["SASS6",null,"MR1","TCF7L2"]
["WDR46",null,"MRVI1","PALB2"]
["UBE2Q1",null,"NADK","DCAF6"]
["BMS1",null,"CDX1","SGPL1"]
["IMMP2L",null,"GSTT2","TAS2R19"]
["RPS11",null,"ICA1L","REV3L"]
["SMARCAL1",null,"HOXD1","SLC7A10"]
["CHCHD3",null,"LGALS2","POLA2"]
["GRINA",null,"MSX2","ZNF266"]
["N6AMT1",null,"SLC19A2","C3orf38"]
["HNRNPU",null,"CLCA1","TSSK4"]
["SPTLC1",null,"PLXDC2","PLG"]
["TRIM28",null,"STC1","OR2T5"]
["E2F4",null,"AMPD3","FECH"]
["GOLGA6B",null,"GPR141","LIG3"]
["KRTAP10-12",null,"IQSEC1","EIF3H"]
["PNOC",null,"MYOT","UROS"]
["RADIL",null,"OXCT2","ZMYND15"]
["RPL36",null,"PCYOX1","ZNF24"]
["TNNT2",null,"PHOX2B","ZNF529"]
["ADNP",null,"TOM1L2","ZNF33B"]
["HIST1H2AK",null,"ZNF286A","CATSPER3"]
["SRRD",null,"CREG1","N6AMT1"]
["TMEM204",null,"AKT1","GMPS"]
["IRF4",null,"APBA3","CBWD2"]
["NME3",null,"LINC01587","CCDC112"]
["RDH10",null,"HCFC2","GPR149"]
["DMBT1",null,"STX1A","OR4D10"]
["C20orf202",null,"TSPO","ZNF141"]
["HIST1H1E",null,"FOXF2","CEP250"]
["TEX10",null,"RAB3B","DNAJB1"]
["NDUFB2",null,"RDH14","MEDAG"]
["BHLHE40",null,"ST3GAL5","NANOG"]
["CD37",null,"STAP2","NR1H2"]
["HMCES",null,"EREG","OLIG3"]
["BAP1",null,"STK10","WFDC11"]
["KLK4",null,"LAMP1","ZBTB18"]
["ELF2",null,"HECTD2","ARGFX"]
["ATP5D",null,"JAM3","IPO8"]
["HIST1H2BL",null,"TUSC1","PEX1"]
["CBWD2",null,"CLDN3","WDR93"]
["C18orf25",null,"CHST12","ABCD4"]
["NIT1",null,"PDXP","BEST3"]
["SLC35F3",null,"EMB","CDC40"]
["VSIG10L",null,"GFI1","ZMYM5"]
["SART1",null,"HLA-DQB1","ICOS"]
["CA5A",null,"L3MBTL3","SCN5A"]
["DDX58",null,"SLC30A10","TTBK1"]
["POLE3",null,"TBC1D10B","ZNF418"]
["TPM1",null,"SIAH2","POLR1E"]
["PBK",null,"INHBA","KAT6A"]
["APRT",null,"TINAGL1","SAMD8"]
["MAD2L1BP",null,"SERPINB12","SLC7A9"]
["NPIPA1",null,"TARBP1","CRYGC"]
["SFMBT2",null,"CTBS","COX15"]
["DSCC1",null,"NPTXR","KBTBD3"]
["NDUFA4",null,"PCOLCE2","SENP8"]
["GOT2",null,"KCNC3","PMCH"]
["LIAS",null,"LY9","GOLGA6L6"]
["FAM136A",null,"RSF1","IKZF3"]
["FETUB",null,"SOX6","TM9SF4"]
["HUS1",null,"GNAI3","PICALM"]
["ZNF768",null,"MMP20","ARID3B"]
["H3F3A",null,"PNPLA3","DDX39B"]
["RBM17",null,"SPSB2","GOLGB1"]
["SIGLEC14",null,"GDF7","POM121L2"]
["ZNF324",null,"FAM184B","GPR179"]
["SPRR2F",null,"AGXT","INO80"]
["TUSC2",null,"LIMS3","ATP2B1"]
["EXOSC1",null,"YIPF5","CDH12"]
["TUBE1",null,"CREB5","DHX8"]
["TVP23A",null,"ELF5","ANP32A"]
["MISP",null,"LMNB1","ESF1"]
["PRSS1",null,"OR4K17","AATF"]
["GATAD1",null,"RSBN1","LZTFL1"]
["AKR1C1",null,"ZNF814","DIRAS2"]
["MRPS26",null,"CTNNA1","SNRPG"]
["CYC1",null,"SLC24A2","U2SURP"]
["PCMTD2",null,"CREM","XKR4"]
["FAM135B",null,"TNR","EXOC5"]
["SRRM2",null,"OXTR","ILF2"]
["ZNF324B",null,"DDAH1","INS"]
["H2AFZ",null,"TYROBP","IL17C"]
["ZNF676",null,"TEX261","PHYH"]
["NASP",null,"PRPF38A","ATP5L2"]
["HIST1H3A",null,"APOBEC3H","CABLES2"]
["KRTAP13-2",null,"IDI1","PXDNL"]
["RAB22A",null,"SPSB4","UBE2B"]
["MFSD1",null,"TMEM254","ZBBX"]
["TTF2",null,"GJB3","COMMD6"]
["ALG2",null,"HCRT","IL11RA"]
["CRX",null,"IRAK2","CPNE7"]
["EBNA1BP2",null,"MEOX2","LTA4H"]
["NKAIN3",null,"POTEE","OTOR"]
["ISCA2",null,"TYW3","SHPRH"]
["INO80B",null,"CCDC42","AKR1C1"]
["ZNHIT3",null,"CHIC2","ANKRD20A2"]
["HIST1H2BJ",null,"C3orf58","DAPP1"]
["MED19",null,"CDCA4","IPO13"]
["SAA1",null,"PRMT6","NAA15"]
["ALKBH4",null,"SMCP","POLR1D"]
["C8orf44",null,"TGOLN2","RNF103"]
["DNAAF5",null,"DDX60","TRIM69"]
["MGAT2",null,"ROBO3","VPS26A"]
["NAA30",null,"HLA-DRB5","DCAKD"]
["PIAS4",null,"VIM","ITPA"]
["NDUFB9",null,"FOXG1","CYB5R4"]
["LYPLA1",null,"HLA-DQA1","HIST1H2BD"]
["ZDHHC7",null,"KRTCAP3","GLE1"]
["CCDC74B",null,"MAB21L2","TEX29"]
["NIPA2",null,"MARVELD3","NLRC5"]
["CHMP5",null,"MNDA","OR2L13"]
["TRAPPC6B",null,"PTPN5","SNAI3"]
["FKBP6",null,"CCDC7","SYNGR2"]
["STIL",null,"FAM50B","ZNF169"]
["ENTPD8",null,"WDR45B","CASC1"]
["MBTD1",null,"GFOD1","OR7G2"]
["ZNF124",null,"FAM43A","PELI2"]
["DECR2",null,"GRB14","ZNF148"]
["GDF3",null,"CEL","IFT122"]
["CLPP",null,"MAP7D1","SLC2A13"]
["ME2",null,"RPL13A","CDK10"]
["OR2L3",null,"CD58","CNOT10"]
["MPG",null,"FOXP2","DDX27"]
["PRSS21",null,"B3GAT1","MYO1B"]
["CELF5",null,"KCNJ15","OR13D1"]
["RIOK2",null,"PCDHAC1","PITPNM3"]
["TFAP4",null,"FAM181B","RASSF8"]
["TTC39C",null,"TMPRSS11F","COMMD5"]
["ANKRD30A",null,"TRPC4AP","EMP1"]
["HEATR3",null,"MTF2","TEX101"]
["SDF2",null,"LSM14B","FBXL5"]
["RPS3A",null,"FBXO6","HIST1H3E"]
["LCN1",null,"ARFGAP1","INHA"]
["MSRB2",null,"GM2A","KRT6A"]
["NDUFA10",null,"FAM210B","PNKP"]
["PDCD5",null,"GPSM1","PTGIS"]
["TNFSF4",null,"CD69","VPS37B"]
["PDGFRL",null,"ASB18","CST2"]
["IRF5",null,"CNR2","LRRC18"]
["NDUFB4",null,"GMPPA","ZFP3"]
["NDUFB7",null,"GRB2","ABHD10"]
["ATP5E",null,"KCNA5","ADAM2"]
["CEP192",null,"LMO4","GPHN"]
["DUSP12",null,"LOR","MPV17L"]
["FAM210A",null,"RPS10","SDCBP"]
["ZFAND5",null,"TRAF3IP1","STK11"]
["NDUFAF3",null,"TSPAN1","UBE2I"]
["ARHGAP39",null,"ZNF254","NDEL1"]
["EXOSC10",null,"ZNF474","MSL1"]
["TRIM38",null,"GPN3","C10orf99"]
["LAIR2",null,"PRKCG","JPH2"]
["TERF2IP",null,"ZIC1","HDGF"]
["C17orf58",null,"CLPP","KLRB1"]
["HSF1",null,"SERPINH1","OTUD4"]
["USP17L2",null,"CBX6","AAAS"]
["RAB11FIP3",null,"DUSP2","ADSL"]
["RHBDF1",null,"IL36RN","AHCY"]
["SLC25A22",null,"LIMCH1","CAPRIN2"]
["ISG20",null,"PDHX","FBXW12"]
["ZNF174",null,"PRSS16","IMPACT"]
["SRCAP",null,"SOCS1","MAPK6"]
["ABCF2",null,"ZXDC","NACA2"]
["FH",null,"AP2A1","PRH2"]
["RPIA",null,"ATP6V1C2","PTBP3"]
["MED23",null,"DEF6","SLC5A8"]
["NDUFS1",null,"PIK3C2B","SLC7A5"]
["SLC12A9",null,"SNRPF","TMOD3"]
["MMP17",null,"NAT16","UROC1"]
["OR2T27",null,"CYP27C1","WDR46"]
["RIOK1",null,"PLEKHA6","ZNF845"]
["DYRK1A",null,"YWHAQ","SDHB"]
["ZNF592",null,"FEZ2","GOLGA6L1"]
["NSUN3",null,"SLC43A1","RTN4RL1"]
["PTBP1",null,"DEPDC1B","NOS1AP"]
["TMEM87A",null,"RTCA","PLS1"]
["PARP1",null,"ZNF219","SPATA16"]
["RNF39",null,"CADPS2","NAP1L4"]
["C9orf131",null,"HMGN4","ABCA1"]
["NPL",null,"POLDIP3","CST4"]
["RPL9",null,"HTR6","SERF2"]
["STK11",null,"SLC39A9","CES3"]
["AKIRIN1",null,"SLC6A4","UPF3A"]
["LGR5",null,"ALPP","FNTA"]
["MXRA7",null,"LRRN1","GNB4"]
["TAS2R38",null,"ACSS2","HSD17B4"]
["USP53",null,"CRP","NFYC"]
["TUBD1",null,"GNG7","VASP"]
["MYO1C",null,"ARHGAP44","VPS13A"]
["PRCC",null,"IMP3","ERCC8"]
["SHARPIN",null,"AK3","SLC35G3"]
["ZNF511",null,"PPTC7","UBN1"]
["CTRB2",null,"NR1H3","AK1"]
["KISS1R",null,"OLIG2","HNMT"]
["TESK1",null,"ADAMTS6","MRGPRX1"]
["CPOX",null,"GTPBP4","TAGLN3"]
["MTMR9",null,"ZNF408","UNC45A"]
["TAF4",null,"GPR158","FNBP1"]
["KAT7",null,"LMNA","SPTLC1"]
["CLCN7",null,"TNFSF9","GLT6D1"]
["COMMD6",null,"PRMT8","PGM2"]
["SPATA5L1",null,"TSHR","AAMP"]
["TRPM5",null,"MCC","CES1"]
["COASY",null,"TFCP2","HMGB1"]
["EIF3J",null,"INPP5F","NEK6"]
["FAM153A",null,"ZNF530","SHCBP1"]
["IRF7",null,"HIST2H2AA3","UGT2B11"]
["ITGA8",null,"NLK","IL10"]
["MAPK8IP3",null,"PGM1","MAP3K1"]
["RPL31",null,"CCT4","RP1"]
["VPS9D1",null,"CHEK1","APEH"]
["ABHD11",null,"DMRTB1","HSF2"]
["CLSPN",null,"TRIM27","KREMEN1"]
["DFFB",null,"TRMT13","OR5T2"]
["GTF2IRD2",null,"ALPPL2","SHISA5"]
["2018-03-09",null,"EIF4A3","NINJ1"]
["CPA1",null,"PTPRC","TRPV1"]
["KRTAP10-1",null,"RAVER2","UBE2D3"]
["UBR5",null,"ASB4","CUBN"]
["C2orf69",null,"C3orf67","GIP"]
["TRMT1",null,"CDK20","MDC1"]
["MAP2K2",null,"HNRNPDL","SIRT4"]
["ULK3",null,"SMOC2","UGT2B4"]
["NSUN5",null,"PPID","IGFL2"]
["TSC2",null,"CNTNAP5","PCDH9"]
["NUDT4",null,"GLDN","C11orf63"]
["SLC35G1",null,"MFSD5","ZNF322"]
["PPP2R3C",null,"MTUS2","AARD"]
["RPL32",null,"NANOGNB","ALOXE3"]
["PHLDA2",null,"NRG2","GRK6"]
["NDUFS5",null,"PCDHA5","KCNJ4"]
["BCCIP",null,"TMPRSS4","2018-03-09"]
["IL31RA",null,"TTC30B","SPATA13"]
["MRPL19",null,"ZBTB4","TLN2"]
["PALB2",null,"KBTBD8","ZC3H11A"]
["RPP40",null,"SLC30A1","KRBA2"]
["C2orf49",null,"GPR37","DIAPH1"]
["CSPP1",null,"HLA-DOA","LIMD1"]
["DUOX1",null,"LBH","UNC119"]
["CGB2",null,"CCDC170","HESX1"]
["HIST1H2BC",null,"MPV17L2","PPCDC"]
["YAF2",null,"TXNDC5","TMEM132B"]
["EIF6",null,"ALDH1L2","FOXA2"]
["ZG16B",null,"FAM89A","MMAB"]
["STRC",null,"NUTF2","OR3A3"]
["GNL1",null,"ABCG1","SPG11"]
["PRAM1",null,"GALNT3","TEX30"]
["UQCR11",null,"INPP5B","CASS4"]
["CAPN9",null,"TRIML1","ORC3"]
["NPIPB6",null,"TSHZ2","CEND1"]
["ABCC6",null,"SLC6A5","GART"]
["CTNNB1",null,"BARX2","TREML2"]
["FAM72B",null,"TWIST1","CD79B"]
["HIST1H2BN",null,"HEBP2","DNAL1"]
["TINF2",null,"TNFSF18","PPP3CA"]
["IQCH",null,"AQP11","RNMT"]
["GJD4",null,"PSEN2","RTN4RL2"]
["TACC1",null,"SPEN","CTNNB1"]
["HIST1H2AE",null,"LMX1B","SCN10A"]
["HIST1H2BH",null,"AAED1","VAC14"]
["MRPS18B",null,"ACYP2","ZNF174"]
["MKI67",null,"HOXA4","DENND4A"]
["UQCR10",null,"PTPN12","SLC7A6"]
["VKORC1L1",null,"SCRG1","LAMTOR2"]
["LACTB",null,"TCF3","ZNF676"]
["ENO3",null,"CASQ1","C14orf105"]
["TMEM140",null,"OR52E8","DDX23"]
["CS",null,"FGF4","DHX36"]
["IL12A",null,"MAP3K6","FUZ"]
["PARP10",null,"LXN","GRIK2"]
["SNAP29",null,"TRIM58","NCR2"]
["NDUFS8",null,"RASAL2","UMPS"]
["ZNF600",null,"SLC39A4","ENPP5"]
["C6orf118",null,"ANKRD45","RHCG"]
["HIST1H2BK",null,"TNK2","CALCRL"]
["MIS18BP1",null,"PDZD8","CDV3"]
["NBEA",null,"SH2D3A","CEP192"]
["KLHDC3",null,"IQUB","DEFA5"]
["BRCA2",null,"HMG20B","FAM162A"]
["ZNF460",null,"MARC2","FREM2"]
["ARPP19",null,"DGKQ","HBG1"]
["CYCS",null,"EGFL7","KIAA1551"]
["RPS27L",null,"GSE1","KRT76"]
["VAPB",null,"HAND1","NCOA6"]
["PLIN3",null,"MS4A7","NEK10"]
["SOX6",null,"MSGN1","PARN"]
["CIDEA",null,"NKTR","PSMA8"]
["RRP36",null,"RAB11FIP5","SCRT1"]
["AGO2",null,"SIX5","SLC1A3"]
["BAX",null,"ZNF575","SLC52A1"]
["CCDC78",null,"CYP1B1","CETP"]
["CHD7",null,"PRR16","SPINT1"]
["CNBP",null,"DKK3","ATP5G1"]
["DPY19L2",null,"SCN2B","CPEB1"]
["FUT3",null,"DUOX1","DUS2"]
["HBQ1",null,"MLYCD","RIN2"]
["KLHDC8A",null,"C1orf115","SNCG"]
["LETM2",null,"ACVR2B","SLC35G6"]
["MGRN1",null,"ACP1","CDH15"]
["MRPL32",null,"MYL1","NEXN"]
["RPL19",null,"ANXA4","ITPR2"]
["SLC5A2",null,"EIF2B2","ACOX1"]
["SOCS1",null,"CNRIP1","HIST1H4L"]
["TCERG1",null,"PEAK1","POLR3F"]
["ZBTB11",null,"CRYGN","RNF145"]
["ZNF253",null,"DAG1","EIF4B"]
["B4GALT6",null,"GHITM","GTF3C5"]
["FNTA",null,"HOXB6","PIGL"]
["PCF11",null,"IL1B","CLASRP"]
["FUT2",null,"MAST4","TRAF2"]
["SET",null,"MUC1","YTHDF1"]
["USP31",null,"NRG1","LSM1"]
["COX11",null,"RAPGEF3","BRPF1"]
["RNF6",null,"SIGIRR","CLDND1"]
["TNNI3",null,"ZNF799","CLVS1"]
["MGEA5",null,"MCL1","SPIRE1"]
["KIF15",null,"LLGL1","MAP1LC3B2"]
["ATP5L",null,"LAMB1","DDX5"]
["COIL",null,"AKR1C2","VAPA"]
["HIST2H2AC",null,"HSPB6","MARS"]
["TMEM9B",null,"KLK15","SLC26A7"]
["ZNF785",null,"LILRB3","PABPC1"]
["ASPHD1",null,"NKD2","SUPT4H1"]
["POU2F1",null,"SLC39A8","CYP8B1"]
["TBC1D5",null,"TIGD2","ERVFRD-1"]
["CUL2",null,"FZD4","EXOC3"]
["NBPF15",null,"PAPOLG","FAM103A1"]
["SLX4",null,"SOX21","GNL2"]
["COA1",null,"BATF3","GPCPD1"]
["FAM189B",null,"CDK5R2","ING3"]
["FXR1",null,"GBE1","PGBD2"]
["GALNTL5",null,"OCEL1","SERPINI1"]
["JUND",null,"PBXIP1","SRRM1"]
["SLC41A3",null,"ZIC4","TPT1"]
["TOMM7",null,"EID2","COX5A"]
["ZNF343",null,"2018-03-05","FHOD3"]
["KHDRBS3",null,"PCDHA8","TAS2R60"]
["SDHA",null,"SNPH","TDGF1"]
["SURF6",null,"BMP3","VPS18"]
["NDUFB5",null,"EPGN","SMIM14"]
["CRYGN",null,"PPFIA2","TAS2R20"]
["HMGN1",null,"ACP5","RAD51"]
["PTAR1",null,"CNPY1","ST6GALNAC4"]
["DDX56",null,"TLR5","IFITM3"]
["HIST1H1C",null,"COL16A1","BRCA2"]
["ALCAM",null,"EZH2","VN1R2"]
["FRG1",null,"PCSK7","C12orf49"]
["C1orf109",null,"MNX1","CCNA1"]
["COQ2",null,"SIAE","CACNB3"]
["NDUFS3",null,"SMCO2","MGAT2"]
["ZKSCAN5",null,"ACBD6","OR11H1"]
["NDUFAF4",null,"COL6A1","SLC38A11"]
["NRARP",null,"B3GALT6","CTPS1"]
["SPTSSA",null,"RXFP3","GRIN2A"]
["MRPL9",null,"STC2","SLC1A5"]
["DEXI",null,"B3GALNT1","SLC29A3"]
["TRDMT1",null,"CBWD1","CDKL2"]
["FSCN1",null,"ETF1","LTF"]
["RAD51D",null,"FAM160A2","RAP1A"]
["ZEB2",null,"SCUBE2","SLC12A6"]
["RMDN1",null,"AKR1B1","MTRR"]
["SH3GL1",null,"BTNL9","PAPPA"]
["NTHL1",null,"DGAT2","PYGB"]
["PNO1",null,"MRGPRX4","DTX2"]
["XPA",null,"AGFG1","VDAC1"]
["NFIA",null,"COX8A","CLYBL"]
["RMND5B",null,"CSMD2","DGAT1"]
["TTC37",null,"KLF13","WDFY2"]
["TUB",null,"IRX2","ZNF705B"]
["UIMC1",null,"RERGL","MED29"]
["ZNF655",null,"PRAMEF4","OR8U1"]
["GRSF1",null,"TMEM60","PRB2"]
["CHODL",null,"CYP2J2","NRBP1"]
["HCN2",null,"TCF12","PARP4"]
["GBE1",null,"TMEM41B","EXOSC8"]
["GNPNAT1",null,"ENDOG","TRIM40"]
["IPPK",null,"SOX8","PTPN1"]
["RPL10A",null,"C1QTNF2","C9orf131"]
["NCAPG2",null,"HSD17B8","MAP2K1"]
["RNASEH1",null,"KRT37","CD2BP2"]
["KRTAP13-1",null,"PCDHGA8","DCAF16"]
["RAP2A",null,"PHC2","EPPIN"]
["TRAF7",null,"ZNF35","PANK3"]
["TM9SF4",null,"GORAB","PNMA2"]
["MRPS22",null,"UCN","WRAP53"]
["COX4I1",null,"B3GALT4","ZNF98"]
["MKL2",null,"BCL11B","MGLL"]
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["MOGAT3",null,"KCNH2","RGS3"]
["NMRK2",null,"PCDHB2","TPTE"]
["MTCH1",null,"PIGR","TSNAXIP1"]
["DLD",null,"RWDD3","ELF1"]
["IFNA13",null,"DBX2","NACC1"]
["CDYL",null,"LCP2","PIGT"]
["ZNF276",null,"SNCAIP","CYP1A1"]
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["VENTX",null,"PTPRN2","LCN10"]
["YWHAG",null,"C10orf53","PIEZO1"]
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["COG3",null,"SCLY","SLC25A31"]
["HTR3D",null,"TRIM25","SLC7A13"]
["BLK",null,"GORASP2","ATP6V1C1"]
["CFDP1",null,"NCS1","DDIT3"]
["CDK4",null,"ATF6","TGS1"]
["ZC3H11A",null,"ATG4D","CNGA1"]
["SOD2",null,"CASP3","FDX1"]
["XRCC1",null,"CDKN2D","TRHR"]
["FAM193B",null,"UGT1A1","AP3M2"]
["GATS",null,"FAM19A3","P2RY12"]
["CELF2",null,"EBF3","DNAJC22"]
["HIST1H2BD",null,"FAM3C","MAPK7"]
["R3HDM1",null,"SYNJ1","MCMDC2"]
["SGPL1",null,"TAS2R9","NFE2"]
["BRCA1",null,"UNG","TPD52L2"]
["ZZEF1",null,"ACSM2B","MRRF"]
["CTAGE4",null,"FEZ1","NCBP1"]
["HIST2H2BE",null,"SLC28A1","ORC4"]
["UMOD",null,"SLC35D3","TAS2R46"]
["KIAA2013",null,"SPATA31D1","FANCD2OS"]
["CUBN",null,"ADRB2","OCIAD1"]
["FOSL2",null,"ANGEL2","PSMB10"]
["HIST1H3B",null,"BARX1","BICD1"]
["NOB1",null,"RIC8B","CNTRL"]
["ACCSL",null,"C11orf42","CRK"]
["DARS2",null,"ITGB4","LENG1"]
["PRODH2",null,"PACRG","PLEKHF1"]
["PSMF1",null,"TRIM47","UBE2D4"]
["SEC61B",null,null,"CES5A"]
["SERPINF1",null,null,"CYB5D2"]
["UBE2V2",null,null,"POLQ"]
["TPD52L1",null,null,"RMI1"]
["MECR",null,null,"RPS25"]
["UBE2M",null,null,"UGT2B15"]
["COX6B2",null,null,"ATL1"]
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["BAZ1B",null,null,"GGT5"]
["RPS7",null,null,"RPE"]
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["MKRN1",null,null,"CRIPT"]
["SERTAD3",null,null,"FAR2"]
["RNPS1",null,null,"GRK7"]
["DLAT",null,null,"HPSE"]
["GCSH",null,null,"IDH3A"]
["GZMM",null,null,"PHF12"]
["NDUFA11",null,null,"PPAT"]
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["YRDC",null,null,"SLC30A5"]
["FBXL16",null,null,"SLC47A1"]
["NUDT15",null,null,"SPACA7"]
["ATP5C1",null,null,"SREK1"]
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["CYP4F11",null,null,"ZNF263"]
["HYDIN",null,null,"EFHB"]
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["CCNL2",null,null,"PDZD2"]
["MPHOSPH10",null,null,"ABCC11"]
["ABCF1",null,null,"NETO2"]
["AQP12B",null,null,"DCTN6"]
["CSPG4",null,null,"HSP90B1"]
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["RFFL",null,null,"CCR2"]
["CENPO",null,null,"MCM8"]
["HOXA9",null,null,"TICAM1"]
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["AGBL5",null,null,"CINP"]
["GON4L",null,null,"GABPA"]
["ITPK1",null,null,"SLC17A2"]
["PLXNA2",null,null,"NUP214"]
["PRDM10",null,null,"POFUT1"]
["SMARCE1",null,null,"ANKS4B"]
["TMEM259",null,null,"GTF2E1"]
["XRCC3",null,null,"TRMT6"]
["CNGA1",null,null,"COX6C"]
["NOA1",null,null,"STRN3"]
["ACTR5",null,null,"VPS9D1"]
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["MAX",null,null,"NARS"]
["UBXN2B",null,null,"STRBP"]
["IL17D",null,null,"PFAS"]
["ZNF311",null,null,"CST9"]
["SLC20A1",null,null,"ZNF677"]
["TBC1D10B",null,null,"CSDE1"]
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["PMM2",null,null,"TNFSF8"]
["RAB24",null,null,"TTC26"]
["RNF40",null,null,"DSE"]
["H3F3B",null,null,"ZNF470"]
["MT1X",null,null,"CCDC144A"]
["SPATA33",null,null,"CPAMD8"]
["COMMD3",null,null,"HOMER2"]
["ATP6V0A4",null,null,"ZBTB2"]
["FN1",null,null,"UPK1A"]
["NOL6",null,null,"DAZAP1"]
["SLC4A1AP",null,null,"KRTAP13-3"]
["TMED7",null,null,"PLEKHO2"]
["CEP152",null,null,"RETNLB"]
["FKBPL",null,null,"VWF"]
["INTS12",null,null,"ARNTL2"]
["JMJD4",null,null,"COL25A1"]
["MANBA",null,null,"SEPT14"]
["MGST2",null,null,"C2orf16"]
["CADM4",null,null,"NDC80"]
["MADCAM1",null,null,"OR5C1"]
["MTA1",null,null,"YBX3"]
["TMX1",null,null,"IQGAP3"]
["CYP2U1",null,null,"TGIF1"]
["LIG4",null,null,"SUCNR1"]
["ACTA1",null,null,"MPZL2"]
["CERS2",null,null,"RTN4"]
["CMC2",null,null,"BRIP1"]
["DCTPP1",null,null,"CHST4"]
["FOXH1",null,null,"GATAD1"]
["KLK5",null,null,"IFIT1"]
["TOX4",null,null,"PAICS"]
["EXOSC4",null,null,"CYP26A1"]
["CD1D",null,null,"MMP25"]
["ELP5",null,null,"ACSM3"]
["EWSR1",null,null,"CELSR3"]
["ARMC10",null,null,"SREBF1"]
["POP5",null,null,"TAB2"]
["ZNF24",null,null,"RAB20"]
["TCOF1",null,null,"ALCAM"]
["ARL13B",null,null,"DNAJC24"]
["FAM207A",null,null,"FASTKD5"]
["POLE2",null,null,"RNF152"]
["SCAND1",null,null,"ZFP28"]
["ZNF133",null,null,"PATL1"]
["FANCL",null,null,"ACADS"]
["MDC1",null,null,"GPX2"]
["PUM2",null,null,"EDNRA"]
["CEP41",null,null,"PACS2"]
["BACE1",null,null,"LYZL4"]
["PON2",null,null,"NIPA2"]
["PSMG1",null,null,"NSRP1"]
["PRKAR2B",null,null,"ZNF569"]
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["IPO5",null,null,"PAQR4"]
["PILRA",null,null,"PDGFC"]
["SMG5",null,null,"GEMIN6"]
["NPAS1",null,null,"TGM3"]
["COL18A1",null,null,"ZNHIT1"]
["EIF1",null,null,"GFPT2"]
["RTN4RL2",null,null,"OR2L5"]
["YWHAZ",null,null,"SPG21"]
["DSCAML1",null,null,"ACVR2A"]
["TRIM49C",null,null,"GLI1"]
["MDK",null,null,"MAP3K7CL"]
["MTCH2",null,null,"MPHOSPH8"]
["ACP6",null,null,"PAX1"]
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["MT2A",null,null,"CKAP2"]
["SLC38A2",null,null,"RPAP1"]
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["MTX1",null,null,"DNAJB8"]
["GADD45B",null,null,"OLA1"]
["HIST1H2AL",null,null,"PIGF"]
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["MUS81",null,null,"ZCCHC17"]
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["GLIS3",null,null,"RYR1"]
["NDUFA3",null,null,"NDRG4"]
["NXN",null,null,"WASF3"]
[{"$nulls":3},"CDK13"]
[{"$nulls":3},"GOLGA6B"]
[{"$nulls":3},"IFI30"]
[{"$nulls":3},"ZER1"]
[{"$nulls":3},"FGF10"]
[{"$nulls":3},"GLMN"]
[{"$nulls":3},"RNF20"]
[{"$nulls":3},"TESK1"]

{"sheet":"S2B. p53 hypergeometric test","index":1,"n_rows":160,"n_cols":13,"rows_kept":160}
["S2B. Significantly enriched pathways for p53 CDE genes (FDR<0.1) with hypergeometric test"]
["We tested for significant overlap of the pathway genes with CDE+/- genes\n"]
[]
["CDE+ genes",{"$nulls":6},"CDE- genes"]
["pathway","# overlapping genes","pathway size","odds ratio","p value","p adjusted",null,"pathway","# overlapping genes","pathway size","odds ratio","p value","p adjusted"]
["Respiratory electron transport",35,71,{"v":16.2584262325978,"d":"16.258"},{"v":1.06897457903121E-24,"d":"1.069E-24"},{"v":2.97174932970676E-22,"d":"2.972E-22"},null,"COPII-mediated vesicle transport",6,60,{"v":8.98460084540386,"d":"8.985"},{"v":1.03653529659517E-4,"d":"1.037E-04"},{"v":0.00459147522414526,"d":"4.591E-03"}]
["Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.",37,83,{"v":13.4747460268064,"d":"13.475"},{"v":4.53963900485064E-24,"d":"4.540E-24"},{"v":6.31009821674239E-22,"d":"6.310E-22"},null,"ER to Golgi Anterograde Transport",8,123,{"v":5.6649341913779,"d":"5.665"},{"v":1.61104393829658E-4,"d":"1.611E-04"},{"v":0.00459147522414526,"d":"4.591E-03"}]
["The citric acid (TCA) cycle and respiratory electron transport",43,129,{"v":8.41558083943308,"d":"8.416"},{"v":9.70970183511175E-22,"d":"9.710E-22"},{"v":8.99765703387022E-20,"d":"8.998E-20"},null,"S Phase",8,135,{"v":5.12493471123573,"d":"5.125"},{"v":3.04973997402927E-4,"d":"3.050E-04"},{"v":0.00579450595065561,"d":"5.795E-03"}]
["Complex I biogenesis",25,44,{"v":21.7781028007025,"d":"21.778"},{"v":5.24365794226511E-20,"d":"5.244E-20"},{"v":3.64434226987425E-18,"d":"3.644E-18"},null,"Transport to the Golgi and subsequent modification",8,154,{"v":4.45293587007598,"d":"4.453"},{"v":7.33981324890385E-4,"d":"7.340E-04"},{"v":0.010459233879688,"d":"1.046E-02"}]
["rRNA processing in the nucleus and cytosol",38,148,{"v":5.76887407062243,"d":"5.769"},{"v":4.10968578455028E-15,"d":"4.110E-15"},{"v":2.28498529620995E-13,"d":"2.285E-13"},null,"Cell Cycle",15,514,{"v":2.48124608988397,"d":"2.481"},{"v":0.00214272472709998,"d":"2.143E-03"},{"v":0.0230464593167784,"d":"2.305E-02"}]
["Homology Directed Repair",32,108,{"v":6.99690298640243,"d":"6.997"},{"v":7.55456920540082E-15,"d":"7.555E-15"},{"v":3.50028373183571E-13,"d":"3.500E-13"},null,"Synthesis of DNA",6,111,{"v":4.60528703490813,"d":"4.605"},{"v":0.0027677263382921,"d":"2.768E-03"},{"v":0.0230464593167784,"d":"2.305E-02"}]
["rRNA processing",38,154,{"v":5.46895007567091,"d":"5.469"},{"v":1.65847124045046E-14,"d":"1.658E-14"},{"v":6.58650006921752E-13,"d":"6.587E-13"},null,"DNA Replication",6,114,{"v":4.47614416671697,"d":"4.476"},{"v":0.00316100873272014,"d":"3.161E-03"},{"v":0.0230464593167784,"d":"2.305E-02"}]
["Major pathway of rRNA processing in the nucleolus and cytosol",36,141,{"v":5.71370751775316,"d":"5.714"},{"v":2.6380348060106E-14,"d":"2.638E-14"},{"v":9.16717095088682E-13,"d":"9.167E-13"},null,"Cell Cycle, Mitotic",13,432,{"v":2.54579829567817,"d":"2.546"},{"v":0.00323459078130222,"d":"3.235E-03"},{"v":0.0230464593167784,"d":"2.305E-02"}]
["HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)",30,103,{"v":6.81443446875152,"d":"6.814"},{"v":8.75297919260062E-14,"d":"8.753E-14"},{"v":2.70369801726997E-12,"d":"2.704E-12"},null,"Cell Cycle Checkpoints",9,244,{"v":3.11079848294022,"d":"3.111"},{"v":0.00375549904240939,"d":"3.755E-03"},{"v":0.0237848272685928,"d":"2.378E-02"}]
["DNA Double-Strand Break Repair",34,134,{"v":5.65445774854871,"d":"5.654"},{"v":1.68758232415347E-13,"d":"1.688E-13"},{"v":4.69147886114664E-12,"d":"4.691E-12"},null,"Immune System",34,1705,{"v":1.73305817185084,"d":"1.733"},{"v":0.00421815576590507,"d":"4.218E-03"},{"v":0.0240434878656589,"d":"2.404E-02"}]
["B-WICH complex positively regulates rRNA expression",20,55,{"v":9.38856053209187,"d":"9.389"},{"v":1.27292277754623E-11,"d":"1.273E-11"},{"v":3.21702301961685E-10,"d":"3.217E-10"},null,"Asparagine N-linked glycosylation",9,262,{"v":2.88588923963598,"d":"2.886"},{"v":0.00594781125671653,"d":"5.948E-03"},{"v":0.0308204765120766,"d":"3.082E-02"}]
["Packaging Of Telomere Ends",15,30,{"v":16.3524924649791,"d":"16.352"},{"v":1.93643786510107E-11,"d":"1.936E-11"},{"v":4.4860810541508E-10,"d":"4.486E-10"},null,"Mitotic Spindle Checkpoint",5,95,{"v":4.45681016575524,"d":"4.457"},{"v":0.00692304539251544,"d":"6.923E-03"},{"v":0.0328844656144483,"d":"3.288E-02"}]
["Positive epigenetic regulation of rRNA expression",22,69,{"v":7.70040508148644,"d":"7.700"},{"v":2.46474835108731E-11,"d":"2.465E-11"},{"v":4.9791969084425E-10,"d":"4.979E-10"},null,"Separation of Sister Chromatids",6,148,{"v":3.39650068110456,"d":"3.397"},{"v":0.0110262609427337,"d":"1.103E-02"},{"v":0.0483459133642941,"d":"4.835E-02"}]
["Telomere Maintenance",19,51,{"v":9.74555479587693,"d":"9.746"},{"v":2.52890207753712E-11,"d":"2.529E-11"},{"v":4.9791969084425E-10,"d":"4.979E-10"},null,"Mitotic Anaphase",6,157,{"v":3.19207961217127,"d":"3.192"},{"v":0.0144233149643019,"d":"1.442E-02"},{"v":0.0544094182348156,"d":"5.441E-02"}]
["DNA Repair",44,247,{"v":3.62176898627642,"d":"3.622"},{"v":2.68661703692941E-11,"d":"2.687E-11"},{"v":4.9791969084425E-10,"d":"4.979E-10"},null,"Mitotic Metaphase and Anaphase",6,158,{"v":3.17085966647496,"d":"3.171"},{"v":0.01484104813731,"d":"1.484E-02"},{"v":0.0544094182348156,"d":"5.441E-02"}]
["Condensation of Prophase Chromosomes",16,36,{"v":13.0894527905686,"d":"13.089"},{"v":3.96765537247671E-11,"d":"3.968E-11"},{"v":6.89380120967828E-10,"d":"6.894E-10"},null,"Adaptive Immune System",15,647,{"v":1.94065726243245,"d":"1.941"},{"v":0.0166022394570098,"d":"1.660E-02"},{"v":0.0544094182348156,"d":"5.441E-02"}]
["SIRT1 negatively regulates rRNA expression",15,32,{"v":14.4266522117781,"d":"14.427"},{"v":6.32283139472568E-11,"d":"6.323E-11"},{"v":1.0339688986669E-9,"d":"1.034E-09"},null,"mRNA Splicing - Major Pathway",6,163,{"v":3.0688135395781,"d":"3.069"},{"v":0.0170564642527164,"d":"1.706E-02"},{"v":0.0544094182348156,"d":"5.441E-02"}]
["DNA methylation",14,29,{"v":15.23979254647,"d":"15.240"},{"v":1.68594931313947E-10,"d":"1.686E-10"},{"v":2.60385505029318E-9,"d":"2.604E-09"},null,"Interleukin-1 family signaling",5,119,{"v":3.51267007525887,"d":"3.513"},{"v":0.0171819215478365,"d":"1.718E-02"},{"v":0.0544094182348156,"d":"5.441E-02"}]
["G2/M DNA damage checkpoint",21,69,{"v":7.18930779972447,"d":"7.189"},{"v":1.87516666670688E-10,"d":"1.875E-10"},{"v":2.74366491233954E-9,"d":"2.744E-09"},null,"mRNA Splicing",6,170,{"v":2.93642953023145,"d":"2.936"},{"v":0.0205264373333747,"d":"2.053E-02"},{"v":0.0615793120001241,"d":"6.158E-02"}]
["ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression",16,40,{"v":10.9091053103067,"d":"10.909"},{"v":2.73381367972693E-10,"d":"2.734E-10"},{"v":3.80000101482043E-9,"d":"3.800E-09"},null,"Membrane Trafficking",12,522,{"v":1.90715831885603,"d":"1.907"},{"v":0.0323091583576595,"d":"3.231E-02"},{"v":0.0920811013193296,"d":"9.208E-02"}]
["Meiotic recombination",17,46,{"v":9.60113639213186,"d":"9.601"},{"v":3.3013660930269E-10,"d":"3.301E-10"},{"v":4.29826714340766E-9,"d":"4.298E-09"},null,"M Phase",8,299,{"v":2.21195236028135,"d":"2.212"},{"v":0.0354275525021927,"d":"3.543E-02"},{"v":0.0961604996488087,"d":"9.616E-02"}]
["Chromosome Maintenance",21,71,{"v":6.90114863148999,"d":"6.901"},{"v":3.40150637248088E-10,"d":"3.402E-10"},{"v":4.29826714340766E-9,"d":"4.298E-09"}]
["Meiosis",21,72,{"v":6.76547516304951,"d":"6.765"},{"v":4.54106239904512E-10,"d":"4.541E-10"},{"v":5.2600639455606E-9,"d":"5.260E-09"}]
["Processing of DNA double-strand break ends",21,72,{"v":6.76547516304951,"d":"6.765"},{"v":4.54106239904512E-10,"d":"4.541E-10"},{"v":5.2600639455606E-9,"d":"5.260E-09"}]
["Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3",14,31,{"v":13.4482547006327,"d":"13.448"},{"v":5.1631321735963E-10,"d":"5.163E-10"},{"v":5.74140297703908E-9,"d":"5.741E-09"}]
["PRC2 methylates histones and DNA",15,37,{"v":11.1453521484545,"d":"11.145"},{"v":7.93911344118424E-10,"d":"7.939E-10"},{"v":8.48874437172777E-9,"d":"8.489E-09"}]
["DNA Damage/Telomere Stress Induced Senescence",18,55,{"v":7.97079986273419,"d":"7.971"},{"v":9.96195896434177E-10,"d":"9.962E-10"},{"v":1.02571281188408E-8,"d":"1.026E-08"}]
["Meiotic synapsis",17,51,{"v":8.18738506763072,"d":"8.187"},{"v":2.11149782242218E-9,"d":"2.111E-09"},{"v":2.09641569511916E-8,"d":"2.096E-08"}]
["Amyloid fiber formation",18,63,{"v":6.55178601049708,"d":"6.552"},{"v":1.1472840455999E-8,"d":"1.147E-08"},{"v":1.09981022302335E-7,"d":"1.100E-07"}]
["Nonhomologous End-Joining (NHEJ)",15,44,{"v":8.45249635258458,"d":"8.452"},{"v":1.32450401112738E-8,"d":"1.325E-08"},{"v":1.22737371697804E-7,"d":"1.227E-07"}]
["RHO GTPases activate PKNs",17,57,{"v":6.95518605439869,"d":"6.955"},{"v":1.43110009004994E-8,"d":"1.431E-08"},{"v":1.28337362914156E-7,"d":"1.283E-07"}]
["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks",16,51,{"v":7.47402154574166,"d":"7.474"},{"v":1.69737174121054E-8,"d":"1.697E-08"},{"v":1.47459170017666E-7,"d":"1.475E-07"}]
["DNA Double Strand Break Response",16,52,{"v":7.26638724529607,"d":"7.266"},{"v":2.31985940942598E-8,"d":"2.320E-08"},{"v":1.95430580551643E-7,"d":"1.954E-07"}]
["Eukaryotic Translation Termination",20,82,{"v":5.28981616890278,"d":"5.290"},{"v":3.46856945657526E-8,"d":"3.469E-08"},{"v":2.83606561449389E-7,"d":"2.836E-07"}]
["Epigenetic regulation of gene expression",23,107,{"v":4.49934931413566,"d":"4.499"},{"v":4.29728261604013E-8,"d":"4.297E-08"},{"v":3.33759375478044E-7,"d":"3.338E-07"}]
["Eukaryotic Translation Elongation",20,83,{"v":5.20563521350869,"d":"5.206"},{"v":4.32206385511137E-8,"d":"4.322E-08"},{"v":3.33759375478044E-7,"d":"3.338E-07"}]
["Pre-NOTCH Transcription and Translation",16,56,{"v":6.53865252659226,"d":"6.539"},{"v":7.47399947485285E-8,"d":"7.474E-08"},{"v":5.48209352580016E-7,"d":"5.482E-07"}]
["Viral mRNA Translation",19,78,{"v":5.27576035332947,"d":"5.276"},{"v":7.78605468032961E-8,"d":"7.786E-08"},{"v":5.48209352580016E-7,"d":"5.482E-07"}]
["Deposition of new CENPA-containing nucleosomes at the centromere",14,43,{"v":7.87695293809507,"d":"7.877"},{"v":7.88790435366929E-8,"d":"7.888E-08"},{"v":5.48209352580016E-7,"d":"5.482E-07"}]
["Nucleosome assembly",14,43,{"v":7.87695293809507,"d":"7.877"},{"v":7.88790435366929E-8,"d":"7.888E-08"},{"v":5.48209352580016E-7,"d":"5.482E-07"}]
["Reproduction",21,94,{"v":4.71957901878104,"d":"4.720"},{"v":8.19200710216231E-8,"d":"8.192E-08"},{"v":5.55458042536859E-7,"d":"5.555E-07"}]
["Peptide chain elongation",19,80,{"v":5.10228605110821,"d":"5.102"},{"v":1.20299547317315E-7,"d":"1.203E-07"},{"v":7.96268432243183E-7,"d":"7.963E-07"}]
["Cell Cycle",60,514,{"v":2.21117375691888,"d":"2.211"},{"v":2.18108209846934E-7,"d":"2.181E-07"},{"v":1.39071395124892E-6,"d":"1.391E-06"}]
["Formation of a pool of free 40S subunits",20,91,{"v":4.61665125507771,"d":"4.617"},{"v":2.21141871847988E-7,"d":"2.211E-07"},{"v":1.39071395124892E-6,"d":"1.391E-06"}]
["Cap-dependent Translation Initiation",22,108,{"v":4.19818268158464,"d":"4.198"},{"v":2.30118135818167E-7,"d":"2.301E-07"},{"v":1.39071395124892E-6,"d":"1.391E-06"}]
["Eukaryotic Translation Initiation",22,108,{"v":4.19818268158464,"d":"4.198"},{"v":2.30118135818167E-7,"d":"2.301E-07"},{"v":1.39071395124892E-6,"d":"1.391E-06"}]
["L13a-mediated translational silencing of Ceruloplasmin expression",21,100,{"v":4.35934919328309,"d":"4.359"},{"v":2.5143408681532E-7,"d":"2.514E-07"},{"v":1.48720587520551E-6,"d":"1.487E-06"}]
["Selenocysteine synthesis",19,84,{"v":4.78768844681685,"d":"4.788"},{"v":2.7450915548379E-7,"d":"2.745E-07"},{"v":1.58986552551028E-6,"d":"1.590E-06"}]
["GTP hydrolysis and joining of the 60S ribosomal subunit",21,101,{"v":4.30457630329416,"d":"4.305"},{"v":3.00229179194558E-7,"d":"3.002E-07"},{"v":1.70334105747117E-6,"d":"1.703E-06"}]
["Senescence-Associated Secretory Phenotype (SASP)",17,69,{"v":5.34569975973974,"d":"5.346"},{"v":3.14475996418956E-7,"d":"3.145E-07"},{"v":1.7484865400894E-6,"d":"1.748E-06"}]
["Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)",19,85,{"v":4.71415877914489,"d":"4.714"},{"v":3.34430662296882E-7,"d":"3.344E-07"},{"v":1.82297498271634E-6,"d":"1.823E-06"}]
["Formation of the beta-catenin:TCF transactivating complex",15,55,{"v":6.1229385223521,"d":"6.123"},{"v":3.73966576241204E-7,"d":"3.740E-07"},{"v":1.99598282273544E-6,"d":"1.996E-06"}]
["G2/M Checkpoints",25,138,{"v":3.63662807758755,"d":"3.637"},{"v":3.80529099298483E-7,"d":"3.805E-07"},{"v":1.99598282273544E-6,"d":"1.996E-06"}]
["NoRC negatively regulates rRNA expression",17,70,{"v":5.24469840485536,"d":"5.245"},{"v":3.92992018359069E-7,"d":"3.930E-07"},{"v":2.02318113155225E-6,"d":"2.023E-06"}]
["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)",21,103,{"v":4.19905276971153,"d":"4.199"},{"v":4.24810078753352E-7,"d":"4.248E-07"},{"v":2.10887860523986E-6,"d":"2.109E-06"}]
["Nonsense-Mediated Decay (NMD)",21,103,{"v":4.19905276971153,"d":"4.199"},{"v":4.24810078753352E-7,"d":"4.248E-07"},{"v":2.10887860523986E-6,"d":"2.109E-06"}]
["Negative epigenetic regulation of rRNA expression",17,72,{"v":5.05358422717299,"d":"5.054"},{"v":6.05591160115287E-7,"d":"6.056E-07"},{"v":2.95358495635175E-6,"d":"2.954E-06"}]
["Pre-NOTCH Expression and Processing",16,66,{"v":5.22733380846172,"d":"5.227"},{"v":8.83921762006405E-7,"d":"8.839E-07"},{"v":4.23672844547898E-6,"d":"4.237E-06"}]
["RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function",15,60,{"v":5.44004862658302,"d":"5.440"},{"v":1.2698229640714E-6,"d":"1.270E-06"},{"v":5.98323362731948E-6,"d":"5.983E-06"}]
["SRP-dependent cotranslational protein targeting to membrane",20,101,{"v":4.04410493574623,"d":"4.044"},{"v":1.29694456444409E-6,"d":"1.297E-06"},{"v":6.00917648192429E-6,"d":"6.009E-06"}]
["HDR through Homologous Recombination (HRR)",15,61,{"v":5.32180916896285,"d":"5.322"},{"v":1.59385529824114E-6,"d":"1.594E-06"},{"v":7.26379955591864E-6,"d":"7.264E-06"}]
["Resolution of D-loop Structures through Holliday Junction Intermediates",10,28,{"v":9.03191050091888,"d":"9.032"},{"v":2.22475756845502E-6,"d":"2.225E-06"},{"v":9.9755258714596E-6,"d":"9.976E-06"}]
["Activation of HOX genes during differentiation",17,80,{"v":4.40936680835575,"d":"4.409"},{"v":2.91328832993436E-6,"d":"2.913E-06"},{"v":1.26545961831524E-5,"d":"1.265E-05"}]
["Activation of anterior HOX genes in hindbrain development during early embryogenesis",17,80,{"v":4.40936680835575,"d":"4.409"},{"v":2.91328832993436E-6,"d":"2.913E-06"},{"v":1.26545961831524E-5,"d":"1.265E-05"}]
["Metabolism of RNA",62,581,{"v":1.99407980095528,"d":"1.994"},{"v":2.97932810413582E-6,"d":"2.979E-06"},{"v":1.2742357122304E-5,"d":"1.274E-05"}]
["Resolution of D-Loop Structures",10,29,{"v":8.55634704527325,"d":"8.556"},{"v":3.21846498041587E-6,"d":"3.218E-06"},{"v":1.3556564614479E-5,"d":"1.356E-05"}]
["Cellular Senescence",24,149,{"v":3.14957588592368,"d":"3.150"},{"v":5.61214930712433E-6,"d":"5.612E-06"},{"v":2.32862314534413E-5,"d":"2.329E-05"}]
["Estrogen-dependent gene expression",20,111,{"v":3.59693904705714,"d":"3.597"},{"v":5.96852437958004E-6,"d":"5.969E-06"},{"v":2.44007320224008E-5,"d":"2.440E-05"}]
["HDACs deacetylate histones",13,52,{"v":5.42963186670903,"d":"5.430"},{"v":6.47154651597814E-6,"d":"6.472E-06"},{"v":2.60737671223467E-5,"d":"2.607E-05"}]
["Oxidative Stress Induced Senescence",17,86,{"v":4.02450072535992,"d":"4.025"},{"v":8.20557233908324E-6,"d":"8.206E-06"},{"v":3.23275277935717E-5,"d":"3.233E-05"}]
["Transcriptional regulation by small RNAs",15,69,{"v":4.53122884634442,"d":"4.531"},{"v":8.25631105519278E-6,"d":"8.256E-06"},{"v":3.23275277935717E-5,"d":"3.233E-05"}]
["Influenza Viral RNA Transcription and Replication",19,105,{"v":3.61277508765533,"d":"3.613"},{"v":9.51334408768218E-6,"d":"9.513E-06"},{"v":3.67320785607729E-5,"d":"3.673E-05"}]
["RUNX1 regulates transcription of genes involved in differentiation of HSCs",17,88,{"v":3.91072679309541,"d":"3.911"},{"v":1.13205704134011E-5,"d":"1.132E-05"},{"v":4.3111213355144E-5,"d":"4.311E-05"}]
["ESR-mediated signaling",20,117,{"v":3.37300543568244,"d":"3.373"},{"v":1.35424787236396E-5,"d":"1.354E-05"},{"v":5.01974544689576E-5,"d":"5.020E-05"}]
["Influenza Infection",20,117,{"v":3.37300543568244,"d":"3.373"},{"v":1.35424787236396E-5,"d":"1.354E-05"},{"v":5.01974544689576E-5,"d":"5.020E-05"}]
["Selenoamino acid metabolism",19,108,{"v":3.49025198912404,"d":"3.490"},{"v":1.44855070645427E-5,"d":"1.449E-05"},{"v":5.298646005188E-5,"d":"5.299E-05"}]
["Influenza Life Cycle",19,109,{"v":3.45122570802101,"d":"3.451"},{"v":1.65991528154429E-5,"d":"1.660E-05"},{"v":5.99294088661446E-5,"d":"5.993E-05"}]
["rRNA modification in the nucleus and cytosol",11,42,{"v":5.77031059638661,"d":"5.770"},{"v":2.06617758204572E-5,"d":"2.066E-05"},{"v":7.36406881806038E-5,"d":"7.364E-05"}]
["Regulation of expression of SLITs and ROBOs",23,153,{"v":2.89777834949997,"d":"2.898"},{"v":2.76731680317502E-5,"d":"2.767E-05"},{"v":9.73815280104626E-5,"d":"9.738E-05"}]
["Translation",33,263,{"v":2.36122437539695,"d":"2.361"},{"v":2.82424244812327E-5,"d":"2.824E-05"},{"v":9.81424250722835E-5,"d":"9.814E-05"}]
["Cell Cycle Checkpoints",31,244,{"v":2.39242556358173,"d":"2.392"},{"v":3.84646250441769E-5,"d":"3.846E-05"},{"v":1.32014392126928E-4,"d":"1.320E-04"}]
["Signaling by Nuclear Receptors",23,157,{"v":2.810476914877,"d":"2.810"},{"v":4.20242501867441E-5,"d":"4.202E-05"},{"v":1.41101942693339E-4,"d":"1.411E-04"}]
["Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)",8,24,{"v":8.10842330165168,"d":"8.108"},{"v":4.21275584300258E-5,"d":"4.213E-05"},{"v":1.41101942693339E-4,"d":"1.411E-04"}]
["Mitotic Prophase",17,98,{"v":3.42515281228246,"d":"3.425"},{"v":4.86708074226399E-5,"d":"4.867E-05"},{"v":1.61077195993975E-4,"d":"1.611E-04"}]
["Metabolism",142,1785,{"v":1.46813436003144,"d":"1.468"},{"v":6.28408115531058E-5,"d":"6.284E-05"},{"v":2.05526418961922E-4,"d":"2.055E-04"}]
["RNA Polymerase II Transcription",95,1100,{"v":1.58591878246468,"d":"1.586"},{"v":6.80508168820273E-5,"d":"6.805E-05"},{"v":2.19978222013995E-4,"d":"2.200E-04"}]
["Generic Transcription Pathway",87,994,{"v":1.60480366632275,"d":"1.605"},{"v":8.81821488440193E-5,"d":"8.818E-05"},{"v":2.81777441133763E-4,"d":"2.818E-04"}]
["Gene expression (Transcription)",102,1220,{"v":1.53120769078814,"d":"1.531"},{"v":1.27742779550398E-4,"d":"1.277E-04"},{"v":4.02733380669143E-4,"d":"4.027E-04"}]
["Citric acid cycle (TCA cycle)",7,21,{"v":8.10009987235236,"d":"8.100"},{"v":1.28932629063143E-4,"d":"1.289E-04"},{"v":4.02733380669143E-4,"d":"4.027E-04"}]
["Fanconi Anemia Pathway",8,28,{"v":6.48685611684819,"d":"6.487"},{"v":1.44435070078651E-4,"d":"1.444E-04"},{"v":4.46143883131834E-4,"d":"4.461E-04"}]
["E3 ubiquitin ligases ubiquitinate target proteins",11,52,{"v":4.36008350107487,"d":"4.360"},{"v":1.70471551982655E-4,"d":"1.705E-04"},{"v":5.2078122473822E-4,"d":"5.208E-04"}]
["Glyoxylate metabolism and glycine degradation",8,29,{"v":6.17755056540858,"d":"6.178"},{"v":1.89316674796721E-4,"d":"1.893E-04"},{"v":5.72065604277047E-4,"d":"5.721E-04"}]
["Gene Silencing by RNA",15,92,{"v":3.17264104949107,"d":"3.173"},{"v":2.71425847708233E-4,"d":"2.714E-04"},{"v":8.11358985622461E-4,"d":"8.114E-04"}]
["Mitochondrial protein import",10,47,{"v":4.38831545323924,"d":"4.388"},{"v":3.18551072769209E-4,"d":"3.186E-04"},{"v":9.42097853508938E-4,"d":"9.421E-04"}]
["Transcriptional regulation by RUNX1",24,191,{"v":2.350449559277,"d":"2.350"},{"v":3.2934118433152E-4,"d":"3.293E-04"},{"v":9.62121743959194E-4,"d":"9.621E-04"}]
["Homologous DNA Pairing and Strand Exchange",9,39,{"v":4.86753002356512,"d":"4.868"},{"v":3.32243479928355E-4,"d":"3.322E-04"},{"v":9.62121743959194E-4,"d":"9.621E-04"}]
["M Phase",33,299,{"v":2.03622304327359,"d":"2.036"},{"v":3.36775441035514E-4,"d":"3.368E-04"},{"v":9.65191470184258E-4,"d":"9.652E-04"}]
["Signaling by ROBO receptors",24,194,{"v":2.30839277713621,"d":"2.308"},{"v":4.15306198827135E-4,"d":"4.153E-04"},{"v":0.00117811350279534,"d":"1.178E-03"}]
["Deubiquitination",27,231,{"v":2.1665215107012,"d":"2.167"},{"v":4.67026448779105E-4,"d":"4.670E-04"},{"v":0.00131144800768274,"d":"1.311E-03"}]
["Protein ubiquitination",12,69,{"v":3.42147166519713,"d":"3.421"},{"v":5.97722794657692E-4,"d":"5.977E-04"},{"v":0.00166166936914838,"d":"1.662E-03"}]
["HATs acetylate histones",14,89,{"v":3.0369707563243,"d":"3.037"},{"v":6.24596465796526E-4,"d":"6.246E-04"},{"v":0.00171918631179638,"d":"1.719E-03"}]
["Cell Cycle, Mitotic",42,432,{"v":1.77071923574647,"d":"1.771"},{"v":8.41255037513698E-4,"d":"8.413E-04"},{"v":0.00229283235714518,"d":"2.293E-03"}]
["Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S",10,53,{"v":3.77416967043751,"d":"3.774"},{"v":8.72918715631573E-4,"d":"8.729E-04"},{"v":0.00235603303830658,"d":"2.356E-03"}]
["Base Excision Repair",8,36,{"v":4.63111986317688,"d":"4.631"},{"v":9.27377693145514E-4,"d":"9.274E-04"},{"v":0.00245534284470907,"d":"2.455E-03"}]
["Resolution of Abasic Sites (AP sites)",8,36,{"v":4.63111986317688,"d":"4.631"},{"v":9.27377693145514E-4,"d":"9.274E-04"},{"v":0.00245534284470907,"d":"2.455E-03"}]
["Cellular responses to stress",34,330,{"v":1.88349253197001,"d":"1.883"},{"v":9.53463930729168E-4,"d":"9.535E-04"},{"v":0.00250059408247838,"d":"2.501E-03"}]
["Metabolism of amino acids and derivatives",33,323,{"v":1.86451176586038,"d":"1.865"},{"v":0.00129585060140152,"d":"1.296E-03"},{"v":0.00336678941298712,"d":"3.367E-03"}]
["Chromatin modifying enzymes",23,201,{"v":2.10895193089019,"d":"2.109"},{"v":0.00158441798968452,"d":"1.584E-03"},{"v":0.00404099267093851,"d":"4.041E-03"}]
["Chromatin organization",23,201,{"v":2.10895193089019,"d":"2.109"},{"v":0.00158441798968452,"d":"1.584E-03"},{"v":0.00404099267093851,"d":"4.041E-03"}]
["Infectious disease",33,329,{"v":1.82576140220679,"d":"1.826"},{"v":0.00175700192574064,"d":"1.757E-03"},{"v":0.00444042304868998,"d":"4.440E-03"}]
["Metabolism of proteins",131,1759,{"v":1.34795239075267,"d":"1.348"},{"v":0.0018501774171808,"d":"1.850E-03"},{"v":0.00463377767546181,"d":"4.634E-03"}]
["Cellular responses to external stimuli",37,383,{"v":1.7533322007032,"d":"1.753"},{"v":0.00186879168048132,"d":"1.869E-03"},{"v":0.0046386079211947,"d":"4.639E-03"}]
["Signaling by NOTCH",21,182,{"v":2.1265553765636,"d":"2.127"},{"v":0.00223874651900273,"d":"2.239E-03"},{"v":0.00545356489617715,"d":"5.454E-03"}]
["Ub-specific processing proteases",20,170,{"v":2.17296053194033,"d":"2.173"},{"v":0.00223928905094237,"d":"2.239E-03"},{"v":0.00545356489617715,"d":"5.454E-03"}]
["Transcriptional Regulation by TP53",32,321,{"v":1.81209109564287,"d":"1.812"},{"v":0.00225597109014522,"d":"2.256E-03"},{"v":0.00545356489617715,"d":"5.454E-03"}]
["TCF dependent signaling in response to WNT",21,184,{"v":2.10020893756872,"d":"2.100"},{"v":0.00255767817054742,"d":"2.558E-03"},{"v":0.00612960802941536,"d":"6.130E-03"}]
["Gap-filling DNA repair synthesis and ligation in GG-NER",6,25,{"v":5.10980741018428,"d":"5.110"},{"v":0.00267080299210143,"d":"2.671E-03"},{"v":0.006346010528241,"d":"6.346E-03"}]
["Ribosomal scanning and start codon recognition",9,52,{"v":3.39304295359606,"d":"3.393"},{"v":0.00291954154196897,"d":"2.920E-03"},{"v":0.00682044158544012,"d":"6.820E-03"}]
["Translation initiation complex formation",9,52,{"v":3.39304295359606,"d":"3.393"},{"v":0.00291954154196897,"d":"2.920E-03"},{"v":0.00682044158544012,"d":"6.820E-03"}]
["Cristae formation",5,18,{"v":6.21867522348892,"d":"6.219"},{"v":0.00306067556434143,"d":"3.061E-03"},{"v":0.00709056505739099,"d":"7.091E-03"}]
["Formation of the ternary complex, and subsequently, the 43S complex",8,45,{"v":3.50252264533834,"d":"3.503"},{"v":0.00414953122256545,"d":"4.150E-03"},{"v":0.00953363371796029,"d":"9.534E-03"}]
["Presynaptic phase of homologous DNA pairing and strand exchange",7,36,{"v":3.9081873996854,"d":"3.908"},{"v":0.00429784926569034,"d":"4.298E-03"},{"v":0.00979345980214684,"d":"9.793E-03"}]
["RHO GTPase Effectors",24,233,{"v":1.87241866472942,"d":"1.872"},{"v":0.00504711689262462,"d":"5.047E-03"},{"v":0.0114073048467451,"d":"1.141E-02"}]
["Developmental Biology",67,841,{"v":1.42628419382059,"d":"1.426"},{"v":0.00589204626747677,"d":"5.892E-03"},{"v":0.0131457225317103,"d":"1.315E-02"}]
["TP53 Regulates Metabolic Genes",10,68,{"v":2.79538790313836,"d":"2.795"},{"v":0.00591084646209996,"d":"5.911E-03"},{"v":0.0131457225317103,"d":"1.315E-02"}]
["Loss of Nlp from mitotic centrosomes",9,59,{"v":2.91662307774945,"d":"2.917"},{"v":0.0069299721607344,"d":"6.930E-03"},{"v":0.0151695453597178,"d":"1.517E-02"}]
["Loss of proteins required for interphase microtubule organization from the centrosome",9,59,{"v":2.91662307774945,"d":"2.917"},{"v":0.0069299721607344,"d":"6.930E-03"},{"v":0.0151695453597178,"d":"1.517E-02"}]
["Metalloprotease DUBs",5,22,{"v":4.75436823974295,"d":"4.754"},{"v":0.0077455081315689,"d":"7.746E-03"},{"v":0.0168222754732512,"d":"1.682E-02"}]
["Pyruvate metabolism and Citric Acid (TCA) cycle",8,50,{"v":3.08450916842209,"d":"3.085"},{"v":0.0079955200717384,"d":"7.996E-03"},{"v":0.017230655658475,"d":"1.723E-02"}]
["Resolution of AP sites via the multiple-nucleotide patch replacement pathway",5,23,{"v":4.48998617675101,"d":"4.490"},{"v":0.00942962716747032,"d":"9.430E-03"},{"v":0.0201648950196673,"d":"2.016E-02"}]
["AURKA Activation by TPX2",9,62,{"v":2.75106280488121,"d":"2.751"},{"v":0.00957864876475214,"d":"9.579E-03"},{"v":0.020327208829016,"d":"2.033E-02"}]
["RMTs methylate histone arginines",7,42,{"v":3.23655237941721,"d":"3.237"},{"v":0.0102545045706335,"d":"1.025E-02"},{"v":0.0215966081108797,"d":"2.160E-02"}]
["Organelle biogenesis and maintenance",20,197,{"v":1.83782702508011,"d":"1.838"},{"v":0.0115170035257735,"d":"1.152E-02"},{"v":0.0240731351892109,"d":"2.407E-02"}]
["Centrosome maturation",9,65,{"v":2.60298882463292,"d":"2.603"},{"v":0.0129275347605072,"d":"1.293E-02"},{"v":0.0262325157913942,"d":"2.623E-02"}]
["Global Genome Nucleotide Excision Repair (GG-NER)",9,65,{"v":2.60298882463292,"d":"2.603"},{"v":0.0129275347605072,"d":"1.293E-02"},{"v":0.0262325157913942,"d":"2.623E-02"}]
["Recruitment of NuMA to mitotic centrosomes",9,65,{"v":2.60298882463292,"d":"2.603"},{"v":0.0129275347605072,"d":"1.293E-02"},{"v":0.0262325157913942,"d":"2.623E-02"}]
["Recruitment of mitotic centrosome proteins and complexes",9,65,{"v":2.60298882463292,"d":"2.603"},{"v":0.0129275347605072,"d":"1.293E-02"},{"v":0.0262325157913942,"d":"2.623E-02"}]
["Regulation of PLK1 Activity at G2/M Transition",10,77,{"v":2.41825884216631,"d":"2.418"},{"v":0.0139429886275429,"d":"1.394E-02"},{"v":0.0280880495540357,"d":"2.809E-02"}]
["Sphingolipid de novo biosynthesis",6,35,{"v":3.34566555543272,"d":"3.346"},{"v":0.0148972048971409,"d":"1.490E-02"},{"v":0.0297944097942819,"d":"2.979E-02"}]
["TRAF6 mediated IRF7 activation",5,27,{"v":3.67266899327882,"d":"3.673"},{"v":0.0186589602575821,"d":"1.866E-02"},{"v":0.0370513639400558,"d":"3.705E-02"}]
["Dual Incision in GG-NER",6,38,{"v":3.0314131990397,"d":"3.031"},{"v":0.0218600606411314,"d":"2.186E-02"},{"v":0.0430999777179754,"d":"4.310E-02"}]
["Apoptotic execution phase",7,49,{"v":2.6956558198502,"d":"2.696"},{"v":0.0229783124684659,"d":"2.298E-02"},{"v":0.0449857103255882,"d":"4.499E-02"}]
["Regulation of TP53 Activity through Phosphorylation",10,84,{"v":2.18850184276382,"d":"2.189"},{"v":0.0244093665177872,"d":"2.441E-02"},{"v":0.0474531740695443,"d":"4.745E-02"}]
["Activation of Matrix Metalloproteinases",5,29,{"v":3.3661775743411,"d":"3.366"},{"v":0.0249401211624,"d":"2.494E-02"},{"v":0.0478162322975669,"d":"4.782E-02"}]
["Transcriptional Regulation by E2F6",5,29,{"v":3.3661775743411,"d":"3.366"},{"v":0.0249401211624,"d":"2.494E-02"},{"v":0.0478162322975669,"d":"4.782E-02"}]
["Regulation of TP53 Activity",15,147,{"v":1.84338361341631,"d":"1.843"},{"v":0.0252244931636595,"d":"2.522E-02"},{"v":0.0480301993116256,"d":"4.803E-02"}]
["UCH proteinases",10,86,{"v":2.13048654624815,"d":"2.130"},{"v":0.0282304580754522,"d":"2.823E-02"},{"v":0.0533882132311274,"d":"5.339E-02"}]
["Recognition of DNA damage by PCNA-containing replication complex",5,30,{"v":3.23132673975129,"d":"3.231"},{"v":0.0285322159321714,"d":"2.853E-02"},{"v":0.0535942974942138,"d":"5.359E-02"}]
["Nucleotide Excision Repair",10,88,{"v":2.07569656494633,"d":"2.076"},{"v":0.0324585970327032,"d":"3.246E-02"},{"v":0.0605603354032985,"d":"6.056E-02"}]
["Mitochondrial biogenesis",7,53,{"v":2.46074636614647,"d":"2.461"},{"v":0.0337798132250092,"d":"3.378E-02"},{"v":0.0626052538436836,"d":"6.261E-02"}]
["Anchoring of the basal body to the plasma membrane",9,79,{"v":2.08039033543903,"d":"2.080"},{"v":0.0406210310574752,"d":"4.062E-02"},{"v":0.0747857392978683,"d":"7.479E-02"}]
["Apoptosis",15,157,{"v":1.71240645094056,"d":"1.712"},{"v":0.0417794399743955,"d":"4.178E-02"},{"v":0.0764123967952761,"d":"7.641E-02"}]
["Interferon alpha/beta signaling",8,68,{"v":2.15658533892055,"d":"2.157"},{"v":0.0441671360252393,"d":"4.417E-02"},{"v":0.0802513974837681,"d":"8.025E-02"}]
["HDR through Single Strand Annealing (SSA)",5,34,{"v":2.78490123098247,"d":"2.785"},{"v":0.0460648294772322,"d":"4.606E-02"},{"v":0.083155990874484,"d":"8.316E-02"}]
["Programmed Cell Death",15,160,{"v":1.6766117512215,"d":"1.677"},{"v":0.0479848378627199,"d":"4.798E-02"},{"v":0.0860631285537814,"d":"8.606E-02"}]

{"sheet":"S2C. KRAS hypergeometric test","index":2,"n_rows":28,"n_cols":8,"rows_kept":28}
["S2C. Significantly enriched pathways for KRAS CDE genes (FDR<0.1) with hypergeometric test"]
["We tested for significant overlap of the pathway genes with CDE+/- genes\n"]
[]
["CDE+ genes",null,"CDE- genes"]
["No significant pathway",null,"pathway","# overlapping genes","pathway size","odds ratio","p value","p adjusted"]
[null,null,"Nucleobase biosynthesis",9,15,{"v":24.1255409123734,"d":"24.126"},{"v":3.03585461343955E-8,"d":"3.04E-08"},{"v":8.80397837897469E-6,"d":"8.80E-06"}]
[null,null,"Purine ribonucleoside monophosphate biosynthesis",7,12,{"v":22.4637684650436,"d":"22.464"},{"v":1.48908732084463E-6,"d":"1.49E-06"},{"v":2.15917661522472E-4,"d":"2.16E-04"}]
[null,null,"p130Cas linkage to MAPK signaling for integrins",6,15,{"v":10.6871115938647,"d":"10.687"},{"v":1.31403698642883E-4,"d":"1.31E-04"},{"v":0.0127023575354787,"d":"1.27E-02"}]
[null,null,"Integrin alphaIIb beta3 signaling",7,27,{"v":5.61403423770164,"d":"5.614"},{"v":7.64449891082708E-4,"d":"7.64E-04"},{"v":0.0380496422103487,"d":"3.80E-02"}]
[null,null,"Integrin signaling",7,27,{"v":5.61403423770164,"d":"5.614"},{"v":7.64449891082708E-4,"d":"7.64E-04"},{"v":0.0380496422103487,"d":"3.80E-02"}]
[null,null,"Glucuronidation",6,20,{"v":6.8682951127936,"d":"6.868"},{"v":7.8878548563921E-4,"d":"7.89E-04"},{"v":0.0380496422103487,"d":"3.80E-02"}]
[null,null,"Amino acid transport across the plasma membrane",7,28,{"v":5.3456699010615,"d":"5.346"},{"v":9.67927230307723E-4,"d":"9.68E-04"},{"v":0.0380496422103487,"d":"3.80E-02"}]
[null,null,"Cobalamin (Cbl, vitamin B12) transport and metabolism",6,21,{"v":6.41030268269768,"d":"6.410"},{"v":0.00104964530235445,"d":"1.05E-03"},{"v":0.0380496422103487,"d":"3.80E-02"}]
[null,null,"Nicotinamide salvaging",5,16,{"v":7.27715883763256,"d":"7.277"},{"v":0.00179277190181254,"d":"1.79E-03"},{"v":0.0577670946139595,"d":"5.78E-02"}]
[null,null,"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)",6,24,{"v":5.34064988715678,"d":"5.341"},{"v":0.00223664696920174,"d":"2.24E-03"},{"v":0.0584561015079751,"d":"5.85E-02"}]
[null,null,"Metabolism",133,1785,{"v":1.33415669006588,"d":"1.334"},{"v":0.00236640865814136,"d":"2.37E-03"},{"v":0.0584561015079751,"d":"5.85E-02"}]
[null,null,"Metabolism of nucleotides",13,91,{"v":2.68083634121071,"d":"2.681"},{"v":0.00257201999488161,"d":"2.57E-03"},{"v":0.0584561015079751,"d":"5.85E-02"}]
[null,null,"Metabolism of water-soluble vitamins and cofactors",15,113,{"v":2.46434258256555,"d":"2.464"},{"v":0.00262044592966785,"d":"2.62E-03"},{"v":0.0584561015079751,"d":"5.85E-02"}]
[null,null,"MAP2K and MAPK activation",7,35,{"v":4.00802241865415,"d":"4.008"},{"v":0.00383421367996949,"d":"3.83E-03"},{"v":0.0742032776426969,"d":"7.42E-02"}]
[null,null,"Transport of inorganic cations/anions and amino acids/oligopeptides",13,96,{"v":2.51857967029481,"d":"2.519"},{"v":0.00413228476646724,"d":"4.13E-03"},{"v":0.0742032776426969,"d":"7.42E-02"}]
[null,null,"Homology Directed Repair",14,108,{"v":2.39600553466445,"d":"2.396"},{"v":0.00445258360319022,"d":"4.45E-03"},{"v":0.0742032776426969,"d":"7.42E-02"}]
[null,null,"Platelet Aggregation (Plug Formation)",7,36,{"v":3.86883290541336,"d":"3.869"},{"v":0.00452194686225269,"d":"4.52E-03"},{"v":0.0742032776426969,"d":"7.42E-02"}]
[null,null,"Transport of Mature mRNA derived from an Intron-Containing Transcript",10,66,{"v":2.86699804952853,"d":"2.867"},{"v":0.00508118618435619,"d":"5.08E-03"},{"v":0.0742032776426969,"d":"7.42E-02"}]
[null,null,"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers",6,28,{"v":4.36886101616112,"d":"4.369"},{"v":0.00511746742363427,"d":"5.12E-03"},{"v":0.0742032776426969,"d":"7.42E-02"}]
[null,null,"Resolution of D-loop Structures through Holliday Junction Intermediates",6,28,{"v":4.36886101616112,"d":"4.369"},{"v":0.00511746742363427,"d":"5.12E-03"},{"v":0.0742032776426969,"d":"7.42E-02"}]
[null,null,"Synthesis of substrates in N-glycan biosythesis",9,57,{"v":3.00856244265261,"d":"3.009"},{"v":0.00584218988283258,"d":"5.84E-03"},{"v":0.0806778602867356,"d":"8.07E-02"}]
[null,null,"Resolution of D-Loop Structures",6,29,{"v":4.1787476985619,"d":"4.179"},{"v":0.00613636271921764,"d":"6.14E-03"},{"v":0.0808884176624143,"d":"8.09E-02"}]
[null,null,"Homologous DNA Pairing and Strand Exchange",7,39,{"v":3.50580860410653,"d":"3.506"},{"v":0.00714703740532184,"d":"7.15E-03"},{"v":0.0901148194584058,"d":"9.01E-02"}]

{"sheet":"S2D. p53 GSEA","index":3,"n_rows":140,"n_cols":8,"rows_kept":140}
["S2D. Significantly enriched pathways for p53 CDE genes (FDR<0.1) with GSEA analysis"]
["The sign of ES and NES scores represents the direction of enrichment (positive values represent pathways enriched by CDE+ genes, negative values represent those enriched by CDE- genes). The table is sorted by adjusted p value and p value."]
[]
["pathway","p value","p adjusted","enrichment score","normalized enrichment score","# more extreme","pathway size","leading edge genes"]
["Metabolism",{"v":1.00735368187771E-4,"d":"1.007E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.246922706841187,"d":"0.247"},{"v":1.33007777520838,"d":"1.330"},0,1409,"BRIP1,INPP5E,PSME3,SPHK2,CYP2A13,PRSS3,NDUFA8,PDXK,RPL27A,SRD5A1,GBA2,INPP4B,PDSS2,NDUFB8,NDUFAF1,NDUFA2,NDUFC1,PHKG1,SLC27A5,FTCD,NDUFB6,NDUFA5,GPC6,NDUFB2,RPL6,RPL34,CA5A,RPL36AL,RPS3,CPNE7,ATP5I,PON1,FDX1,NMRK2,CTRB2,STK11,NDUFB7,NMRAL1,TIMMDC1,LIPT1,SDHD,COX5A,NDUFS1,RPS3A,ENO3,GDE1,CSPG4,AZIN1,MGST2,ITPKC,SGPL1,CPOX,NDUFA11,NDUFS2,LIAS,RPIA,LYPLA1,NDUFB4,CS,PSMF1,ENTPD8,HSD17B12,ISCA2,PANK3,PON2,FPGS,AGXT,MTR,RPS27A,CIDEA,MANBA,ACP6,GOT2,DLAT,AKR1C1,CYP2U1,PARP10,RPS7,RPS8,PRODH2,IPPK,NDUFS8,SLC22A13,NDUFA10,UQCR10,NME3,COX4I1,COQ2,NUDT4,SDHA,FH,DUOX1,SPTSSA,MECR,NDUFA6,AIMP2,NDUFB5,LRP12,AHCY,BCKDK,DLD,NT5C3A,N6AMT1,SIN3A,ITPK1,CYCS,ARSI,CYC1,GYS1,GBE1,HSD3B7,RPL32,SAMHD1,ATP5L,DECR2,MOGAT3,NDUFAF4,NUDT15,APRT,PRSS1,VAPB,AHRR,IMPDH2,SDHB,CYP4F11,PSMB10,CMBL,CPT1B,PPA2,NFYA,PRODH,PLCB4,CYP2S1,FABP5,MVD,LIPE,NUDT12,XYLT1,B4GALT6,PNPLA2,RPL8,UQCRFS1,PSME2,CA2,HSD11B1,GDPD1,FDPS,ELOVL1,PPCDC,MTMR9,NDUFAF3,NDUFAF5,PIAS4,ACOT4,RPS27L,HSD17B7,PAICS,NDUFA4,SPTLC1,ACSM2A,HNMT,PI4K2B,PSMB6,RPL14,PSPH,BDH2,NDUFS5,GSR,SULT2B1,TNFAIP8L3,DPEP2,GNAS,ETFB,COX7C,ETNPPL,NDUFB3,TPMT,ATIC,CPNE1,RPL24,NDUFA3,NDUFS7,GCSH,KMO,PFKL,ADCY9,GPHN,PGM2,PRKAR1B,RPL7,UQCRB,BDH1,NUDT1,VKORC1L1,COQ5,B3GAT2,COX5B,RPL7A,NDUFS3,AMD1,COX10,CYP2E1,OAT,PLEKHA5,SULT1A2,ADCY4,RAB4A,PPAT,RPL30,SUCLG1,COX7A2L,HSD11B2,SEPHS2,CUBN,NME4,SULT1A1,ETFA,CERS2,CHKB,ENO2,RPL19,CDS1,UQCRC1,COASY,GGCT,PSAT1,HMOX2,RPS15A,SLC27A2,TXN2,ADSS,FAH,HS3ST2,MTHFS,ACLY,CPNE3,MARCKS,MLXIPL,NCOA1,PPP1CC,RPL35,SULT4A1,TPI1,UQCRQ,PIK3CD,PRKAR2B,UROC1,NNT,BCKDHB,NUDT7,CREBBP,TYMP,MTMR3,ODC1,OGDH,MBOAT7,SLC25A28,UBB,ACOT8,COX15,HSD17B3,HYAL2,IMPA2,OSBP,GAMT,IMPAD1,COQ7,PHYH,PRKD2,UMPS,APOA1,PSMC2,SLC19A3,STARD7,DUOX2,CYP24A1,GSTA2,NDUFAF2,PGLS,AMPD3,CBR3,EEF1E1,FECH,ACAD9,ADCY2,GYG1,ACSM3,CHKA,D2HGDH,GSTA5,NDUFS6,DERA,ETNK1,GNB2,BPNT1,GIF,GUSB,MMAB,TIAM2,PPOX,SGPP1,CNDP2,GLS,GMPS,RPL37,RPS19,ACSF3,ADA,PSMB9,SLC16A3,LPCAT3,CYP2W1,ARSA,CERK,ACADSB,PAPSS1,IP6K3,PCK1,TPTE2,CA7,MPC2,NDUFV1,SYT5,TST,CYB5B,SDHC,IDH1,DHODH,MAT2B,RPL18A,SGMS1,SUMF2,CPS1,PHKB,PFKFB4,ADIPOR1,PLBD1,ECI1,AKR1D1,ASAH1,ETNK2,FDFT1,PRKAR2A,GDPD3,QPRT,UST,ACADL,ACER2,AGXT2,AK4,DBI,PFKFB2,ECSIT,NT5C,MARC2,COX6C,NAMPT,CYP8B1,TALDO1,ASL,AUH,PAOX,PTGES2,SYNJ2,PPCS,ACSM1,B4GALT7,NMNAT1,RPL28,SCAP,NAGLU,PANK2,PDP2,TYMS,ALOX5,ATP5J2,AOC3,FMO3,SBF2,SLC19A2,TK1,GNAI1,NDUFA13,PYCR1,ACHE,ADSL,AIMP1,SLC6A12,TNFAIP8L2,DPEP1,GLDC,NDC1,NUBPL,PHYKPL,RAB14,ABHD14B,GART,SLC44A2,IMPDH1,MMADHC,PSMD9,DLST,GNAQ,SQLE,AGPAT2,HPSE2,GCH1,PARP16,ASS1,GNB4,GSTT2B,HYKK,NME1"]
["Metabolism of proteins",{"v":1.00765820233777E-4,"d":"1.008E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.254020830107893,"d":"0.254"},{"v":1.36724250847431,"d":"1.367"},0,1367,"UCHL3,WDR48,PSME3,RAB26,RPL27A,AGBL3,RAB40B,WRN,H2AFX,ALG2,NDUFB8,EEF1D,RPL6,RPL34,CTDSP2,H2AFZ,COX17,FN1,RPL36AL,RPS3,TRAPPC6B,ULBP2,HIST1H2BL,CHCHD3,RRAGA,HIST2H2AC,PIGX,CLSPN,RAB22A,RPS3A,DMBT1,HIST1H2BH,PGAP1,EIF4EBP1,INO80B,EIF3J,KEAP1,SMAD1,VCPKMT,COMMD6,CS,PSMF1,UBE2V2,GALNTL5,AGXT,RPS27A,PRSS21,RFWD2,MGAT2,RPS7,YY1,H3F3A,RPS8,HIST1H3A,MTX1,TNIP3,MRPL3,CUL7,MRPL4,TGFB1,COQ2,HIST2H2BE,ABCA3,RTN4RL2,BRCA1,BAP1,APEH,FBXW7,INO80E,KDM1B,DAXX,SEC61B,MEN1,CTSZ,AIMP2,N6AMT1,SIN3A,GGA1,MTA1,PMM2,TRIM28,ARSI,GORASP1,HDAC1,CYC1,HIST1H2BN,RNF7,DPM1,MDC1,UCHL5,PMM1,RPL32,UIMC1,CPB2,DECR2,DDX58,SATB2,DARS2,DPH2,FBXL16,GNPNAT1,SMAD3,FEM1B,KLK2,PSMB10,SAA1,BACE1,MRPL43,PPA2,USP17L2,TMED7,DPM2,UBE2M,DCAF6,MVD,ZBTB17,TNKS,HIST1H2BC,PEX1,B4GALT6,MRPL36,MRPS24,NSMCE4A,DPM3,MSRB2,PNPLA2,RPL8,UBE2W,MUC20,PSME2,UBE2R2,KLHDC3,NPL,MRPS26,MRPL9,APCS,FBXW12,GSK3A,RNF40,MGAT5,F7,MRPL19,PIAS4,TIMM22,MRPS22,ACOT4,RPS27L,HIST1H2BD,KLHL21,PSMB6,LAMB1,MRPL35,RPL14,DPH7,MRPS2,SUZ12,EEF2KMT,NAT8,SEMA5B,MRPL10,USP21,MRPL49,ASXL1,PRL,TMED9,ACTR8,ETFB,LDHD,MRPL21,CARS2,CUL2,ATF6,TUBA3C,RPL24,MRPL28,EIF4H,FBXL13,MTFMT,PIGH,TIMM17A,FBN1,MPI,RPL7,CDC20,COG3,SSR1,UGGT2,COG7,MRPL15,MRPL27,RPL7A,TUBB4B,MRPS11,STAMBP,THBS2,RAB4A,MME,RPL30,SLC30A8,DHRS4,ICMT,EARS2,EXOC3,MRPL16,IGFBP6,IGFBP1,MRPL51,ST8SIA6,HIST1H2AG,MRPS18A,RTN4RL1,ARF4,FBXO22,HIST1H2AJ,RPL19,MRPL18,KIF5B,SKP2,USP4,BTBD1,CMC2,COG5,RAB39A,ACTR5,BECN1,HIST3H2A,MRPL40,RPN2,RPS15A,SIAH1,SLC27A2,SUDS3,DHPS,KIF13A,MRPL1,NCOA1,RPL35,CHCHD1,CCT5,HARS2,WDR61,CTSH,MRPS16,NFRKB,NUDT7,KNG1,CREBBP,MRPS10,PIGO,TSFM,HIST3H2BB,MRPL13,MRPL2,EDEM3,FBXL12,NGLY1,RGS11,SEC31A,ADAMTS1,COG4,DPH5,MRPS25,TFAP2C,IDE,UBB,WAC,ACOT8,EIF3L,SHPRH,CMAS,YARS2,DCUN1D4,MRPL38,PHYH,AGBL2,APOA1,CXXC1,HIST2H2BF,KBTBD6,PSMC2,USP16,KLHL11,RNF5,SYVN1,EEF1E1,MYO5A,C3,EEF1B2,NOD1,EXOC7,ZNF350,HERC2,ATF4,COG1,PFDN6,RAB40C,CMA1,COA6,GNB2,HIST1H2BK,MRPS17,TTLL2,HIST1H4A,OXA1L,RAB18,RPL37,RPS19,PSMB9,SEC63,DOLK,MRPL34,ARSA,FBXW11,COPS6,MRPS27,USP48,GNE,PIGZ,TUBB1,ATF3,EIF2S2,EIF3E,MKL1,SEMA5A,DNAJB9,FAM20C,FKBP8,IAPP,NUCB1,RARA,DPH1,FARS2,DAD1,DCUN1D2,IDH1,PHC2,ADAMTSL2,DDB2,GAS6,HDGF,MAT2B,RPL18A,SUMF2,ITM2B,SRP19,XPC,NICN1"]
["Gene expression (Transcription)",{"v":1.02354145342886E-4,"d":"1.024E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.286282204484559,"d":"0.286"},{"v":1.52564300833554,"d":"1.526"},0,978,"TAF8,EXO1,ZNF417,BRIP1,EHMT1,ZNF425,PSME3,TAF1D,PAPOLA,WRN,H2AFX,CDK5,ZNF668,TAF3,ZNF771,ZNF587,RAD9A,NELFA,ZNF705A,CTNNB1,DDX21,H2AFZ,MAML1,CCNG1,ZNF688,TSC2,TWISTNB,YWHAE,CCNT1,CPSF4,HIST1H2BL,RRAGA,HIST2H2AC,HUS1,STK11,ZNF655,YAF2,COX5A,BAX,DROSHA,ZNF324B,HIST1H2BH,ZKSCAN5,RAD1,SMAD1,POU2F1,ZNF133,PSMF1,EED,CCNT2,ZFP28,TAF4,RPS27A,ELF2,ZNF155,ZNF343,SETD1A,MED23,RNPS1,ZNF460,BAZ1B,YY1,H3F3A,POLR1E,HIST1H3A,RFFL,GATAD2A,COX4I1,HIST2H2BE,BRCA1,CR1,FBXW7,YWHAG,ZNF324,DAXX,MEN1,ZNF676,SMARCD1,ZNF600,INTS12,ZNF785,SIN3A,MTA1,TRIM28,ZNF311,CYCS,HDAC1,HIST1H2BN,ZNF77,MDC1,ZNF124,SMARCA5,ZNF764,SATB2,MYO1C,MAX,SMAD3,ZNF253,RRN3,PSMB10,PIN1,PRKAB1,SRRT,ZNF264,TSC1,CDK4,JMY,ZFP37,PMS2,ZNF446,DPY30,TFDP2,E2F1,HIST1H2BC,RAD51D,ZNF416,TFAM,TFDP1,ZNF79,PSME2,PF4,AGO2,H2AFJ,HNF4G,FANCC,NELFB,NR1I3,MED24,ARID1A,CSTF1,SUPT5H,ESRRA,ZNF100,CNOT4,HIST1H2BD,NDUFA4,INTS10,MED25,PSMB6,CDK6,ZNF418,SUZ12,ZNF493,GSR,KMT2C,ARID1B,ZNF398,DDIT4,ZNF667,EPC1,MEAF6,COX7C,ZNF34,TRIM33,PCF11,TAF13,COX5B,SCO2,SMARCE1,YWHAZ,ZNF786,GP1BA,ABL1,CHTOP,RBL2,BTG2,COX7A2L,SRSF7,UCMA,ZC3H11A,NOC2L,BRD2,AGO1,HIST1H2AJ,MED6,SAP30,SKP2,SSRP1,ZNF528,CTSV,MED10,ZNF200,DLX6,RMI2,ZNF552,SUDS3,ZNF92,ZNF3,ARID4B,MED15,WDR61,ZNF263,ZNF692,ZNF33B,CREBBP,HEY1,ITGAL,MOV10L1,HIST3H2BB,MED16,ZNF135,ZNF202,CSTF3,TAF1B,TFAP2C,UBB,ZNF445,INTS3,MLLT1,ZNF606,DLX5,CENPJ,SRSF6,ASZ1,PSMC2,ZNF777,CCND1,ZNF430,ATAD2,CITED2,WWOX,ELL3,TCF3,TDRD9,ZNF350,ZNF205,GTF3C1,MYB,RORB,CCNH,HIST1H2BK,POLR3K,SMYD2,SOCS4,CNOT2,TMEM219,ZNF705D,HIST1H4A,SIRT1,ZNF500,ZNF551,ZNF566,GLS,NR2C2AP,PSMB9,ZNF227,ZNF658,LAMTOR2,EZH2,RARA,ITGA4,THOC6,PHC2,DDB2,ZNF235,ZNF514,KAT6A,TP73,KMT2D,ZNF195,RBM14,RRAGD,TPX2,SRSF9,ZNF433,ZNF689,H2AFV,SRSF5,TJP1,ZNF584,INTS4,PPARD,SLBP,SPI1,CD3EAP,NR3C2,DICER1,KMT2E,TAF1C,COX6C,IL2"]
["RNA Polymerase II Transcription",{"v":1.02669404517454E-4,"d":"1.027E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.288520449412717,"d":"0.289"},{"v":1.532309729478,"d":"1.532"},0,894,"TAF8,EXO1,ZNF417,BRIP1,EHMT1,ZNF425,PSME3,PAPOLA,WRN,H2AFX,CDK5,ZNF668,TAF3,ZNF771,ZNF587,RAD9A,NELFA,ZNF705A,CTNNB1,H2AFZ,MAML1,CCNG1,ZNF688,TSC2,YWHAE,CCNT1,CPSF4,HIST1H2BL,RRAGA,HIST2H2AC,HUS1,STK11,ZNF655,YAF2,COX5A,BAX,ZNF324B,HIST1H2BH,ZKSCAN5,RAD1,SMAD1,POU2F1,ZNF133,PSMF1,EED,CCNT2,ZFP28,TAF4,RPS27A,ELF2,ZNF155,ZNF343,SETD1A,MED23,RNPS1,ZNF460,YY1,H3F3A,HIST1H3A,RFFL,GATAD2A,COX4I1,HIST2H2BE,BRCA1,CR1,FBXW7,YWHAG,ZNF324,DAXX,MEN1,ZNF676,SMARCD1,ZNF600,INTS12,ZNF785,SIN3A,TRIM28,ZNF311,CYCS,HDAC1,HIST1H2BN,ZNF77,MDC1,ZNF124,ZNF764,SATB2,MAX,SMAD3,ZNF253,PSMB10,PIN1,PRKAB1,SRRT,ZNF264,TSC1,CDK4,JMY,ZFP37,PMS2,ZNF446,DPY30,TFDP2,E2F1,HIST1H2BC,RAD51D,ZNF416,TFDP1,ZNF79,PSME2,PF4,AGO2,H2AFJ,HNF4G,FANCC,NELFB,NR1I3,MED24,ARID1A,CSTF1,SUPT5H,ESRRA,ZNF100,CNOT4,HIST1H2BD,NDUFA4,INTS10,MED25,PSMB6,CDK6,ZNF418,SUZ12,ZNF493,GSR,KMT2C,ARID1B,ZNF398,DDIT4,ZNF667,EPC1,MEAF6,COX7C,ZNF34,TRIM33,PCF11,TAF13,COX5B,SCO2,SMARCE1,YWHAZ,ZNF786,GP1BA,ABL1,CHTOP,RBL2,BTG2,COX7A2L,SRSF7,UCMA,ZC3H11A,NOC2L,BRD2,AGO1,HIST1H2AJ,MED6,SKP2,SSRP1,ZNF528,CTSV,MED10,ZNF200,DLX6,RMI2,ZNF552,ZNF92,ZNF3,MED15,WDR61,ZNF263,ZNF692,ZNF33B,CREBBP,HEY1,ITGAL,HIST3H2BB,MED16,ZNF135,ZNF202,CSTF3,TFAP2C,UBB,ZNF445,INTS3,MLLT1,ZNF606,DLX5,CENPJ,SRSF6,PSMC2,ZNF777,CCND1,ZNF430,ATAD2,CITED2,WWOX,ELL3,TCF3,ZNF350,ZNF205,MYB,RORB,CCNH,HIST1H2BK,SMYD2,SOCS4,CNOT2,TMEM219,ZNF705D,HIST1H4A,ZNF500,ZNF551,ZNF566,GLS,NR2C2AP,PSMB9,ZNF227,ZNF658,LAMTOR2,EZH2,RARA,ITGA4,THOC6,PHC2,DDB2,ZNF235,ZNF514,KAT6A,TP73,KMT2D,ZNF195,RBM14,RRAGD,TPX2,SRSF9,ZNF433,ZNF689,H2AFV,SRSF5,TJP1,ZNF584,INTS4,PPARD,SLBP,SPI1,NR3C2,KMT2E,COX6C,IL2"]
["Generic Transcription Pathway",{"v":1.03092783505155E-4,"d":"1.031E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.289394313656778,"d":"0.289"},{"v":1.53123715067604,"d":"1.531"},0,808,"EXO1,ZNF417,BRIP1,EHMT1,ZNF425,PSME3,WRN,H2AFX,CDK5,ZNF668,TAF3,ZNF771,ZNF587,RAD9A,NELFA,ZNF705A,CTNNB1,H2AFZ,MAML1,CCNG1,ZNF688,TSC2,YWHAE,CCNT1,HIST1H2BL,RRAGA,HIST2H2AC,HUS1,STK11,ZNF655,YAF2,COX5A,BAX,ZNF324B,HIST1H2BH,ZKSCAN5,RAD1,SMAD1,ZNF133,PSMF1,EED,CCNT2,ZFP28,TAF4,RPS27A,ELF2,ZNF155,ZNF343,SETD1A,MED23,ZNF460,YY1,H3F3A,HIST1H3A,RFFL,GATAD2A,COX4I1,HIST2H2BE,BRCA1,CR1,FBXW7,YWHAG,ZNF324,DAXX,MEN1,ZNF676,SMARCD1,ZNF600,ZNF785,SIN3A,TRIM28,ZNF311,CYCS,HDAC1,HIST1H2BN,ZNF77,MDC1,ZNF124,ZNF764,SATB2,MAX,SMAD3,ZNF253,PSMB10,PIN1,PRKAB1,ZNF264,TSC1,CDK4,JMY,ZFP37,PMS2,ZNF446,DPY30,TFDP2,E2F1,HIST1H2BC,RAD51D,ZNF416,TFDP1,ZNF79,PSME2,PF4,AGO2,H2AFJ,HNF4G,FANCC,NELFB,NR1I3,MED24,ARID1A,SUPT5H,ESRRA,ZNF100,CNOT4,HIST1H2BD,NDUFA4,MED25,PSMB6,CDK6,ZNF418,SUZ12,ZNF493,GSR,KMT2C,ARID1B,ZNF398,DDIT4,ZNF667,EPC1,MEAF6,COX7C,ZNF34,TRIM33,TAF13,COX5B,SCO2,SMARCE1,YWHAZ,ZNF786,GP1BA,ABL1,RBL2,BTG2,COX7A2L,UCMA,NOC2L,BRD2,AGO1,HIST1H2AJ,MED6,SKP2,SSRP1,ZNF528,CTSV,MED10,ZNF200,DLX6,RMI2,ZNF552,ZNF92,ZNF3,MED15,ZNF263,ZNF692,ZNF33B,CREBBP,HEY1,ITGAL,HIST3H2BB,MED16,ZNF135,ZNF202,TFAP2C,UBB,ZNF445,ZNF606,DLX5,CENPJ,PSMC2,ZNF777,CCND1,ZNF430,ATAD2,CITED2,WWOX,TCF3,ZNF350,ZNF205,MYB,RORB,CCNH,HIST1H2BK,SMYD2,SOCS4,CNOT2,TMEM219,ZNF705D,HIST1H4A,ZNF500,ZNF551,ZNF566,GLS,NR2C2AP,PSMB9,ZNF227,ZNF658,LAMTOR2,EZH2,RARA,ITGA4,PHC2,DDB2,ZNF235,ZNF514,KAT6A,TP73,KMT2D,ZNF195,RBM14,RRAGD,TPX2,ZNF433,ZNF689,H2AFV,TJP1,ZNF584,PPARD,SPI1,NR3C2,KMT2E,COX6C,IL2"]
["Transcriptional Regulation by TP53",{"v":1.16265550517382E-4,"d":"1.163E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.340041363052118,"d":"0.340"},{"v":1.66062596880642,"d":"1.661"},0,257,"EXO1,BRIP1,EHMT1,WRN,CDK5,TAF3,RAD9A,NELFA,CCNG1,TSC2,YWHAE,CCNT1,RRAGA,HUS1,STK11,COX5A,BAX,RAD1,CCNT2,TAF4,RPS27A,RFFL,GATAD2A,COX4I1,BRCA1,YWHAG,DAXX,CYCS,HDAC1,MDC1,PIN1,PRKAB1,TSC1,JMY,PMS2,TFDP2,E2F1,RAD51D,TFDP1,AGO2,FANCC,NELFB,SUPT5H,CNOT4,NDUFA4,GSR,DDIT4,MEAF6,COX7C,TAF13,COX5B,SCO2,YWHAZ,RBL2,BTG2,COX7A2L,NOC2L,AGO1,SSRP1,RMI2"]
["Translation",{"v":1.19688809096349E-4,"d":"1.197E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.445011326176408,"d":"0.445"},{"v":2.1158785594859,"d":"2.116"},0,199,"RPL27A,EEF1D,RPL6,RPL34,RPL36AL,RPS3,RPS3A,EIF4EBP1,EIF3J,RPS27A,RPS7,RPS8,MRPL3,MRPL4,APEH,SEC61B,AIMP2,N6AMT1,RPL32,DARS2,MRPL43,PPA2,MRPL36,MRPS24,RPL8,MRPS26,MRPL9,MRPL19,MRPS22,RPS27L,MRPL35,RPL14,MRPS2,MRPL10,MRPL49,MRPL21,CARS2,RPL24,MRPL28,EIF4H,MTFMT,RPL7,SSR1,MRPL15,MRPL27,RPL7A,MRPS11,RPL30,EARS2,MRPL16,MRPL51,MRPS18A,RPL19,MRPL18,MRPL40,RPN2,RPS15A,MRPL1,RPL35,CHCHD1,HARS2,MRPS16,MRPS10,TSFM,MRPL13,MRPL2,MRPS25,EIF3L,YARS2,MRPL38,EEF1E1,EEF1B2,MRPS17,OXA1L,RPL37,RPS19,MRPL34,MRPS27,EIF2S2,EIF3E,FARS2,RPL18A,SRP19,ERAL1,MRPS23,MRPL24,MRPS15,RPL28,MRPS6,SRP72,AIMP1,MRPL47,TUFM,FARSB,EIF4G1,MRPL39,AURKAIP1,MARS,MTRF1L,RPS25"]
["DNA Repair",{"v":1.19932837610938E-4,"d":"1.199E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.359128937483097,"d":"0.359"},{"v":1.70364099423059,"d":"1.704"},0,195,"EXO1,WDR48,BRIP1,WRN,H2AFX,FANCG,RAD9A,HIST1H2BL,MPG,HUS1,CLSPN,POLE4,NTHL1,HIST1H2BH,POLE3,RAD1,UBE2V2,RPS27A,FANCA,OGG1,BAZ1B,LIG1,PPP4R2,FANCL,SLX4,HIST2H2BE,XRCC3,BRCA1,SIRT6,XPA,TDP2,HIST1H2BN,MDC1,UIMC1,SMARCA5,PMS2,LIG4,HMGN1,HIST1H2BC,RAD51D,BRCA2,FANCC,EME2,PIAS4,HIST1H2BD,POLE2,POLN,ABL1,PAXIP1,XRCC1,RAD51B,RMI2,KPNA2,HIST3H2BB,UBB,FEN1,MUS81,XRCC2,APEX1,HERC2,CCNH,HIST1H2BK,HIST1H4A"]
["Chromatin modifying enzymes",{"v":1.22895416000983E-4,"d":"1.229E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.404754814909474,"d":"0.405"},{"v":1.88687100789062,"d":"1.887"},0,170,"EHMT1,H2AFX,H2AFZ,HIST1H2BL,HIST2H2AC,HIST1H2BH,EED,SETD1A,MORF4L1,HIST1H3A,GATAD2A,HIST2H2BE,KDM1B,KDM5A,SMARCD1,ELP5,MTA1,HDAC1,HIST1H2BN,MBIP,SUPT20H,KDM4C,CDK4,SETDB1,DPY30,HIST1H2BC,H2AFJ,ARID1A,HIST1H2BD,SUZ12,KMT2C,ARID1B,EPC1,MEAF6,SMARCE1,SUPT7L,KAT7,HIST1H2AG,HIST1H2AJ,SAP30,TAF5L,HIST3H2A,SUDS3,NCOA1,ARID4B,CREBBP,HIST3H2BB,KDM2A,SETD2,HIST2H2BF,CCND1,RCOR1,HIST1H2BK,SMYD2,HIST1H4A,VPS72,TADA2A,EZH2,DR1,MSL1,KAT6A,KMT2D,H2AFV,BRWD1,KMT2E,YEATS2,KANSL3,PRMT7,ELP2,DOT1L"]
["Chromatin organization",{"v":1.22895416000983E-4,"d":"1.229E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.404754814909474,"d":"0.405"},{"v":1.88687100789062,"d":"1.887"},0,170,"EHMT1,H2AFX,H2AFZ,HIST1H2BL,HIST2H2AC,HIST1H2BH,EED,SETD1A,MORF4L1,HIST1H3A,GATAD2A,HIST2H2BE,KDM1B,KDM5A,SMARCD1,ELP5,MTA1,HDAC1,HIST1H2BN,MBIP,SUPT20H,KDM4C,CDK4,SETDB1,DPY30,HIST1H2BC,H2AFJ,ARID1A,HIST1H2BD,SUZ12,KMT2C,ARID1B,EPC1,MEAF6,SMARCE1,SUPT7L,KAT7,HIST1H2AG,HIST1H2AJ,SAP30,TAF5L,HIST3H2A,SUDS3,NCOA1,ARID4B,CREBBP,HIST3H2BB,KDM2A,SETD2,HIST2H2BF,CCND1,RCOR1,HIST1H2BK,SMYD2,HIST1H4A,VPS72,TADA2A,EZH2,DR1,MSL1,KAT6A,KMT2D,H2AFV,BRWD1,KMT2E,YEATS2,KANSL3,PRMT7,ELP2,DOT1L"]
["rRNA processing",{"v":1.29802699896158E-4,"d":"1.298E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.49904414774496,"d":"0.499"},{"v":2.21358650702564,"d":"2.214"},0,114,"THUMPD1,TEX10,RPL27A,WDR46,RPL6,RPL34,RPL36AL,RPS3,HEATR1,GAR1,RPS3A,EXOSC1,EXOSC10,RPS27A,BMS1,RPS7,RPS8,RIOK1,NOB1,WDR75,RPL32,NOL6,PNO1,RRP36,RPP40,RIOK2,RPL8,TRMT10C,RPS27L,RPL14,RPL24,RPL7,WDR3,RPL7A,RPL30,RPL19,RPS15A,RPL35,EXOSC3,EXOSC8,NOP10,EXOSC6"]
["DNA Double-Strand Break Repair",{"v":1.30753138075314E-4,"d":"1.308E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.488277422670665,"d":"0.488"},{"v":2.15108512311191,"d":"2.151"},0,109,"EXO1,BRIP1,WRN,H2AFX,RAD9A,HIST1H2BL,HUS1,CLSPN,POLE4,HIST1H2BH,POLE3,RAD1,UBE2V2,RPS27A,BAZ1B,PPP4R2,SLX4,HIST2H2BE,XRCC3,BRCA1,SIRT6,TDP2,HIST1H2BN,MDC1,UIMC1,SMARCA5,LIG4,HIST1H2BC,RAD51D,BRCA2,EME2,PIAS4,HIST1H2BD,POLE2,ABL1,PAXIP1,XRCC1,RAD51B,RMI2,KPNA2,HIST3H2BB,UBB,FEN1,MUS81,XRCC2,HERC2,HIST1H2BK,HIST1H4A"]
["rRNA processing in the nucleus and cytosol",{"v":1.30753138075314E-4,"d":"1.308E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.511188219155994,"d":"0.511"},{"v":2.24992027848542,"d":"2.250"},0,108,"THUMPD1,TEX10,RPL27A,WDR46,RPL6,RPL34,RPL36AL,RPS3,HEATR1,GAR1,RPS3A,EXOSC1,EXOSC10,RPS27A,BMS1,RPS7,RPS8,RIOK1,NOB1,WDR75,RPL32,NOL6,PNO1,RRP36,RPP40,RIOK2,RPL8,RPS27L,RPL14,RPL24,RPL7,WDR3,RPL7A,RPL30,RPL19,RPS15A,RPL35,EXOSC3,EXOSC8,NOP10,EXOSC6"]
["The citric acid (TCA) cycle and respiratory electron transport",{"v":1.31371518654756E-4,"d":"1.314E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.609634505701742,"d":"0.610"},{"v":2.66894935109,"d":"2.669"},0,105,"NDUFA8,NDUFB8,NDUFAF1,NDUFA2,NDUFC1,NDUFB6,NDUFA5,NDUFB2,ATP5I,NDUFB7,TIMMDC1,SDHD,COX5A,NDUFS1,NDUFA11,NDUFS2,NDUFB4,CS,DLAT,NDUFS8,NDUFA10,UQCR10,COX4I1,SDHA,FH,NDUFA6,NDUFB5,DLD,CYCS,CYC1,ATP5L,NDUFAF4,SDHB,UQCRFS1,NDUFAF3,NDUFAF5,NDUFA4,NDUFS5,ETFB,COX7C,NDUFB3,NDUFA3,NDUFS7,UQCRB,COX5B,NDUFS3,SUCLG1,COX7A2L,ETFA,UQCRC1,UQCRQ,NNT,OGDH,NDUFAF2,ACAD9,D2HGDH,NDUFS6,SLC16A3,MPC2,NDUFV1,SDHC"]
["Major pathway of rRNA processing in the nucleolus and cytosol",{"v":1.3196093956189E-4,"d":"1.320E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.497093772872968,"d":"0.497"},{"v":2.16426026754435,"d":"2.164"},0,101,"TEX10,RPL27A,WDR46,RPL6,RPL34,RPL36AL,RPS3,HEATR1,RPS3A,EXOSC1,EXOSC10,RPS27A,BMS1,RPS7,RPS8,RIOK1,NOB1,WDR75,RPL32,NOL6,PNO1,RRP36,RPP40,RIOK2,RPL8,RPS27L,RPL14,RPL24,RPL7,WDR3,RPL7A,RPL30,RPL19,RPS15A,RPL35,EXOSC3,EXOSC8,EXOSC6,C1D,RPL37,RPS19"]
["Homology Directed Repair",{"v":1.34680134680135E-4,"d":"1.347E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.527869007486549,"d":"0.528"},{"v":2.24979052955039,"d":"2.250"},0,89,"EXO1,BRIP1,WRN,H2AFX,RAD9A,HIST1H2BL,HUS1,CLSPN,POLE4,HIST1H2BH,POLE3,RAD1,UBE2V2,RPS27A,PPP4R2,SLX4,HIST2H2BE,XRCC3,BRCA1,SIRT6,HIST1H2BN,MDC1,UIMC1,HIST1H2BC,RAD51D,BRCA2,EME2,PIAS4,HIST1H2BD,POLE2,ABL1,XRCC1,RAD51B,RMI2,HIST3H2BB,UBB,FEN1,MUS81,XRCC2,HERC2,HIST1H2BK,HIST1H4A"]
["HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)",{"v":1.35098621994056E-4,"d":"1.351E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.526259045508012,"d":"0.526"},{"v":2.23053040818637,"d":"2.231"},0,86,"EXO1,BRIP1,WRN,H2AFX,RAD9A,HIST1H2BL,HUS1,CLSPN,POLE4,HIST1H2BH,POLE3,RAD1,UBE2V2,RPS27A,PPP4R2,SLX4,HIST2H2BE,XRCC3,BRCA1,SIRT6,HIST1H2BN,MDC1,UIMC1,HIST1H2BC,RAD51D,BRCA2,EME2,PIAS4,HIST1H2BD,POLE2,ABL1,RAD51B,RMI2,HIST3H2BB,UBB,MUS81,XRCC2,HERC2,HIST1H2BK,HIST1H4A"]
["Reproduction",{"v":1.35906496330525E-4,"d":"1.359E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.485869514073796,"d":"0.486"},{"v":2.02757480724058,"d":"2.028"},0,78,"TERF1,H2AFX,H2AFZ,HIST1H2BL,HIST2H2AC,HIST1H2BH,FKBP6,TERF2IP,H3F3A,HIST1H3A,ACR,TERF2,HIST2H2BE,BRCA1,HIST1H2BN,TINF2,CATSPERD,CDK4,HIST1H2BC,ZP3,BRCA2,H2AFJ,REC8,HIST1H2BD,HIST1H2AJ,SYNE1,SYCP3,HIST3H2BB"]
["Oxidative Stress Induced Senescence",{"v":1.38350857775318E-4,"d":"1.384E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.488710365372741,"d":"0.489"},{"v":1.99018074886608,"d":"1.990"},0,69,"H2AFX,H2AFZ,HIST1H2BL,HIST2H2AC,HIST1H2BH,EED,RPS27A,H3F3A,HIST1H3A,HIST2H2BE,HIST1H2BN,CDK4,TFDP2,E2F1,HIST1H2BC,TFDP1,H2AFJ,HIST1H2BD,CDK6,SUZ12,AGO1,HIST1H2AJ,HIST3H2BB,UBB,E2F3,MINK1,HIST1H2BK,HIST1H4A,EZH2,PHC2,H2AFV,MAPK10,MAPK11"]
["Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.",{"v":1.38350857775318E-4,"d":"1.384E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.70481565258651,"d":"0.705"},{"v":2.87022875442247,"d":"2.870"},0,69,"NDUFA8,NDUFB8,NDUFAF1,NDUFA2,NDUFC1,NDUFB6,NDUFA5,NDUFB2,ATP5I,NDUFB7,TIMMDC1,SDHD,COX5A,NDUFS1,NDUFA11,NDUFS2,NDUFB4,NDUFS8,NDUFA10,UQCR10,COX4I1,SDHA,NDUFA6,NDUFB5,CYCS,CYC1,ATP5L,NDUFAF4,SDHB,UQCRFS1,NDUFAF3,NDUFAF5,NDUFA4,NDUFS5,ETFB,COX7C,NDUFB3,NDUFA3,NDUFS7,UQCRB,COX5B,NDUFS3,COX7A2L,ETFA,UQCRC1,UQCRQ,NDUFAF2,ACAD9,NDUFS6"]
["Mitochondrial translation",{"v":1.38638569249965E-4,"d":"1.386E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.629899159367397,"d":"0.630"},{"v":2.54685148657166,"d":"2.547"},0,66,"MRPL3,MRPL4,MRPL43,MRPL36,MRPS24,MRPS26,MRPL9,MRPL19,MRPS22,MRPL35,MRPS2,MRPL10,MRPL49,MRPL21,MRPL28,MTFMT,MRPL15,MRPL27,MRPS11,MRPL16,MRPL51,MRPS18A,MRPL18,MRPL40,MRPL1,CHCHD1,MRPS16,MRPS10,TSFM,MRPL13,MRPL2,MRPS25,MRPL38,MRPS17,OXA1L,MRPL34,MRPS27,ERAL1,MRPS23,MRPL24,MRPS15,MRPS6,MRPL47,TUFM,MRPL39,AURKAIP1,MTRF1L"]
["SRP-dependent cotranslational protein targeting to membrane",{"v":1.38753989177189E-4,"d":"1.388E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.473566539003935,"d":"0.474"},{"v":1.9227397819541,"d":"1.923"},0,68,"RPL27A,RPL6,RPL34,RPL36AL,RPS3,RPS3A,RPS27A,RPS7,RPS8,SEC61B,RPL32,RPL8,RPS27L,RPL14,RPL24,RPL7,SSR1,RPL7A,RPL30,RPL19,RPN2,RPS15A,RPL35"]
["Formation of a pool of free 40S subunits",{"v":1.39958012596221E-4,"d":"1.400E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.498061391342425,"d":"0.498"},{"v":1.99628106967778,"d":"1.996"},0,63,"RPL27A,RPL6,RPL34,RPL36AL,RPS3,RPS3A,EIF3J,RPS27A,RPS7,RPS8,RPL32,RPL8,RPS27L,RPL14,RPL24,RPL7,RPL7A,RPL30,RPL19,RPS15A,RPL35,EIF3L,RPL37,RPS19,EIF3E,RPL18A"]
["Eukaryotic Translation Elongation",{"v":1.4046916701784E-4,"d":"1.405E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.552262308234834,"d":"0.552"},{"v":2.18534873482211,"d":"2.185"},0,58,"RPL27A,EEF1D,RPL6,RPL34,RPL36AL,RPS3,RPS3A,RPS27A,RPS7,RPS8,RPL32,RPL8,RPS27L,RPL14,RPL24,RPL7,RPL7A,RPL30,RPL19,RPS15A,RPL35,EEF1B2,RPL37,RPS19"]
["Negative epigenetic regulation of rRNA expression",{"v":1.40488901376791E-4,"d":"1.405E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.498309740465484,"d":"0.498"},{"v":1.98493105128906,"d":"1.985"},0,61,"TAF1D,H2AFX,H2AFZ,TWISTNB,HIST1H2BL,HIST2H2AC,HIST1H2BH,H3F3A,POLR1E,HIST1H3A,HIST2H2BE,SIN3A,HDAC1,HIST1H2BN,SMARCA5,HIST1H2BC,H2AFJ,HIST1H2BD,HIST1H2AJ,SAP30,SUDS3,ARID4B,HIST3H2BB,TAF1B,CCNH,HIST1H2BK,HIST1H4A,SIRT1,H2AFV,CD3EAP,TAF1C"]
["Respiratory electron transport",{"v":1.40488901376791E-4,"d":"1.405E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.738587831941998,"d":"0.739"},{"v":2.94203745717766,"d":"2.942"},0,61,"NDUFA8,NDUFB8,NDUFAF1,NDUFA2,NDUFC1,NDUFB6,NDUFA5,NDUFB2,NDUFB7,TIMMDC1,SDHD,COX5A,NDUFS1,NDUFA11,NDUFS2,NDUFB4,NDUFS8,NDUFA10,UQCR10,COX4I1,SDHA,NDUFA6,NDUFB5,CYCS,CYC1,NDUFAF4,SDHB,UQCRFS1,NDUFAF3,NDUFAF5,NDUFA4,NDUFS5,ETFB,COX7C,NDUFB3,NDUFA3,NDUFS7,UQCRB,COX5B,NDUFS3,COX7A2L,ETFA,UQCRC1,UQCRQ,NDUFAF2,ACAD9,NDUFS6"]
["Mitochondrial translation elongation",{"v":1.40567894292943E-4,"d":"1.406E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.665475927469651,"d":"0.665"},{"v":2.64572160454788,"d":"2.646"},0,60,"MRPL3,MRPL4,MRPL43,MRPL36,MRPS24,MRPS26,MRPL9,MRPL19,MRPS22,MRPL35,MRPS2,MRPL10,MRPL49,MRPL21,MRPL28,MRPL15,MRPL27,MRPS11,MRPL16,MRPL51,MRPS18A,MRPL18,MRPL40,MRPL1,CHCHD1,MRPS16,MRPS10,TSFM,MRPL13,MRPL2,MRPS25,MRPL38,MRPS17,OXA1L,MRPL34,MRPS27,ERAL1,MRPS23,MRPL24,MRPS15,MRPS6,MRPL47,TUFM,MRPL39,AURKAIP1"]
["Mitochondrial translation initiation",{"v":1.40567894292943E-4,"d":"1.406E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.651176335853983,"d":"0.651"},{"v":2.58887095539272,"d":"2.589"},0,60,"MRPL3,MRPL4,MRPL43,MRPL36,MRPS24,MRPS26,MRPL9,MRPL19,MRPS22,MRPL35,MRPS2,MRPL10,MRPL49,MRPL21,MRPL28,MTFMT,MRPL15,MRPL27,MRPS11,MRPL16,MRPL51,MRPS18A,MRPL18,MRPL40,MRPL1,CHCHD1,MRPS16,MRPS10,MRPL13,MRPL2,MRPS25,MRPL38,MRPS17,OXA1L,MRPL34,MRPS27,ERAL1,MRPS23,MRPL24,MRPS15,MRPS6,MRPL47,MRPL39,AURKAIP1"]
["Mitochondrial translation termination",{"v":1.40567894292943E-4,"d":"1.406E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.643565561951019,"d":"0.644"},{"v":2.55861292784999,"d":"2.559"},0,60,"MRPL3,MRPL4,MRPL43,MRPL36,MRPS24,MRPS26,MRPL9,MRPL19,MRPS22,MRPL35,MRPS2,MRPL10,MRPL49,MRPL21,MRPL28,MRPL15,MRPL27,MRPS11,MRPL16,MRPL51,MRPS18A,MRPL18,MRPL40,MRPL1,CHCHD1,MRPS16,MRPS10,MRPL13,MRPL2,MRPS25,MRPL38,MRPS17,OXA1L,MRPL34,MRPS27,ERAL1,MRPS23,MRPL24,MRPS15,MRPS6,MRPL47,MRPL39,AURKAIP1,MTRF1L"]
["Selenocysteine synthesis",{"v":1.40567894292943E-4,"d":"1.406E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.534382025729129,"d":"0.534"},{"v":2.12453375425529,"d":"2.125"},0,60,"RPL27A,RPL6,RPL34,RPL36AL,RPS3,RPS3A,RPS27A,RPS7,RPS8,RPL32,RPL8,RPS27L,RPL14,RPL24,RPL7,RPL7A,RPL30,SEPHS2,RPL19,RPS15A,RPL35"]
["Meiosis",{"v":1.40706345856198E-4,"d":"1.407E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.541037515086758,"d":"0.541"},{"v":2.1452580582299,"d":"2.145"},0,59,"TERF1,H2AFX,H2AFZ,HIST1H2BL,HIST2H2AC,HIST1H2BH,FKBP6,TERF2IP,H3F3A,HIST1H3A,TERF2,HIST2H2BE,BRCA1,HIST1H2BN,TINF2,CDK4,HIST1H2BC,BRCA2,H2AFJ,REC8,HIST1H2BD,HIST1H2AJ,SYNE1,SYCP3,HIST3H2BB"]
["Processing of DNA double-strand break ends",{"v":1.40706345856198E-4,"d":"1.407E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.561023576444853,"d":"0.561"},{"v":2.2245044283709,"d":"2.225"},0,59,"EXO1,BRIP1,WRN,H2AFX,RAD9A,HIST1H2BL,HUS1,CLSPN,HIST1H2BH,RAD1,UBE2V2,RPS27A,PPP4R2,HIST2H2BE,BRCA1,SIRT6,HIST1H2BN,MDC1,UIMC1,HIST1H2BC,PIAS4,HIST1H2BD,RMI2,HIST3H2BB,UBB,HERC2,HIST1H2BK,HIST1H4A"]
["Eukaryotic Translation Termination",{"v":1.4110342881332E-4,"d":"1.411E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.562220055346478,"d":"0.562"},{"v":2.20931986303324,"d":"2.209"},0,56,"RPL27A,RPL6,RPL34,RPL36AL,RPS3,RPS3A,RPS27A,RPS7,RPS8,APEH,N6AMT1,RPL32,RPL8,RPS27L,RPL14,RPL24,RPL7,RPL7A,RPL30,RPL19,RPS15A,RPL35"]
["G2/M DNA damage checkpoint",{"v":1.4110342881332E-4,"d":"1.411E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.551740637490971,"d":"0.552"},{"v":2.16813957107989,"d":"2.168"},0,56,"EXO1,BRIP1,WRN,H2AFX,RAD9A,YWHAE,HIST1H2BL,HUS1,HIST1H2BH,RAD1,UBE2V2,HIST2H2BE,BRCA1,YWHAG,HIST1H2BN,MDC1,UIMC1,HIST1H2BC,PIAS4,HIST1H2BD,YWHAZ,RMI2,HIST3H2BB,HERC2,HIST1H2BK,HIST1H4A"]
["Pre-NOTCH Expression and Processing",{"v":1.4110342881332E-4,"d":"1.411E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.565123081009547,"d":"0.565"},{"v":2.22072769560578,"d":"2.221"},0,56,"H2AFX,H2AFZ,MAML1,HIST1H2BL,HIST2H2AC,HIST1H2BH,H3F3A,HIST1H3A,HIST2H2BE,PRKCI,SIRT6,HIST1H2BN,TFDP2,E2F1,HIST1H2BC,TFDP1,AGO2,H2AFJ,HIST1H2BD,AGO1,HIST1H2AJ,CREBBP,HIST3H2BB,E2F3,CCND1,HIST1H2BK,HIST1H4A"]
["Peptide chain elongation",{"v":1.41143260409315E-4,"d":"1.411E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.539663347041355,"d":"0.540"},{"v":2.11514035049647,"d":"2.115"},0,55,"RPL27A,RPL6,RPL34,RPL36AL,RPS3,RPS3A,RPS27A,RPS7,RPS8,RPL32,RPL8,RPS27L,RPL14,RPL24,RPL7,RPL7A,RPL30,RPL19,RPS15A,RPL35"]
["Positive epigenetic regulation of rRNA expression",{"v":1.41242937853107E-4,"d":"1.412E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.538690158026975,"d":"0.539"},{"v":2.12185124864924,"d":"2.122"},0,57,"TAF1D,H2AFX,DDX21,H2AFZ,TWISTNB,HIST1H2BL,HIST2H2AC,HIST1H2BH,BAZ1B,H3F3A,POLR1E,HIST1H3A,GATAD2A,HIST2H2BE,MTA1,HDAC1,HIST1H2BN,SMARCA5,MYO1C,HIST1H2BC,H2AFJ,HIST1H2BD,HIST1H2AJ,HIST3H2BB,TAF1B,HIST1H2BK,HIST1H4A,H2AFV,CD3EAP,TAF1C"]
["Viral mRNA Translation",{"v":1.41763538417919E-4,"d":"1.418E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.541854672750973,"d":"0.542"},{"v":2.11685763914634,"d":"2.117"},0,54,"RPL27A,RPL6,RPL34,RPL36AL,RPS3,RPS3A,RPS27A,RPS7,RPS8,RPL32,RPL8,RPS27L,RPL14,RPL24,RPL7,RPL7A,RPL30,RPL19,RPS15A,RPL35"]
["RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function",{"v":1.42348754448399E-4,"d":"1.423E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.57566612339822,"d":"0.576"},{"v":2.22619538743084,"d":"2.226"},0,51,"H2AFX,H2AFZ,HIST1H2BL,HIST2H2AC,HIST1H2BH,SETD1A,H3F3A,HIST1H3A,HIST2H2BE,SIN3A,HDAC1,HIST1H2BN,DPY30,HIST1H2BC,PF4,H2AFJ,HIST1H2BD,KMT2C,GP1BA,AGO1,HIST1H2AJ,HIST3H2BB,HIST1H2BK,HIST1H4A,KMT2D,H2AFV,KMT2E"]
["HDACs deacetylate histones",{"v":1.43143429716576E-4,"d":"1.431E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.521617878288824,"d":"0.522"},{"v":1.99466521411335,"d":"1.995"},0,48,"HIST1H2BL,HIST2H2AC,HIST1H2BH,HIST1H3A,GATAD2A,HIST2H2BE,MTA1,HDAC1,HIST1H2BN,HIST1H2BC,HIST1H2BD,HIST1H2AG,HIST1H2AJ,SAP30,HIST3H2A,SUDS3,ARID4B,HIST3H2BB,HIST2H2BF,RCOR1,HIST1H2BK,HIST1H4A"]
["Pre-NOTCH Transcription and Translation",{"v":1.43822810297713E-4,"d":"1.438E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.613515028019229,"d":"0.614"},{"v":2.33446553288076,"d":"2.334"},0,47,"H2AFX,H2AFZ,MAML1,HIST1H2BL,HIST2H2AC,HIST1H2BH,H3F3A,HIST1H3A,HIST2H2BE,PRKCI,SIRT6,HIST1H2BN,TFDP2,E2F1,HIST1H2BC,TFDP1,AGO2,H2AFJ,HIST1H2BD,AGO1,HIST1H2AJ,CREBBP,HIST3H2BB,E2F3,CCND1,HIST1H2BK,HIST1H4A"]
["RHO GTPases activate PKNs",{"v":1.43822810297713E-4,"d":"1.438E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.557536365118485,"d":"0.558"},{"v":2.12146299317045,"d":"2.121"},0,47,"H2AFX,H2AFZ,YWHAE,HIST1H2BL,HIST2H2AC,HIST1H2BH,H3F3A,HIST1H3A,HIST2H2BE,MYH14,YWHAG,HIST1H2BN,KLK2,KDM4C,HIST1H2BC,H2AFJ,HIST1H2BD,YWHAZ,HIST1H2AJ,HIST3H2BB,HIST1H2BK,HIST1H4A"]
["Formation of the beta-catenin:TCF transactivating complex",{"v":1.45327713995059E-4,"d":"1.453E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.605705919742455,"d":"0.606"},{"v":2.27904526905636,"d":"2.279"},0,45,"H2AFX,CTNNB1,H2AFZ,HIST1H2BL,HIST2H2AC,HIST1H2BH,H3F3A,HIST1H3A,HIST2H2BE,MEN1,BCL9,HDAC1,HIST1H2BN,HIST1H2BC,PYGO2,H2AFJ,HIST1H2BD,HIST1H2AJ,CREBBP,HIST3H2BB,TLE2,HIST1H2BK,HIST1H4A,KMT2D,TCF4,H2AFV,LEF1"]
["B-WICH complex positively regulates rRNA expression",{"v":1.45878920495988E-4,"d":"1.459E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.581197310816523,"d":"0.581"},{"v":2.17693336153469,"d":"2.177"},0,44,"TAF1D,H2AFX,DDX21,H2AFZ,TWISTNB,HIST1H2BL,HIST2H2AC,HIST1H2BH,BAZ1B,H3F3A,POLR1E,HIST1H3A,HIST2H2BE,HIST1H2BN,SMARCA5,MYO1C,HIST1H2BC,H2AFJ,HIST1H2BD,HIST1H2AJ,HIST3H2BB,TAF1B,HIST1H2BK,HIST1H4A,H2AFV,CD3EAP,TAF1C"]
["Telomere Maintenance",{"v":1.46177459435755E-4,"d":"1.462E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.573943485215069,"d":"0.574"},{"v":2.14104264158797,"d":"2.141"},0,43,"TERF1,H2AFX,H2AFZ,HIST1H2BL,HIST2H2AC,POLE4,HIST1H2BH,POLE3,TERF2IP,LIG1,TERF2,HIST2H2BE,HIST1H2BN,TINF2,HIST1H2BC,H2AFJ,HIST1H2BD,POLE2,HIST1H2AJ,HIST3H2BB,FEN1,HIST1H2BK,HIST1H4A"]
["Meiotic synapsis",{"v":1.46412884333821E-4,"d":"1.464E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.597583768362653,"d":"0.598"},{"v":2.22005523268876,"d":"2.220"},0,42,"TERF1,H2AFX,H2AFZ,HIST1H2BL,HIST2H2AC,HIST1H2BH,FKBP6,TERF2IP,TERF2,HIST2H2BE,BRCA1,HIST1H2BN,TINF2,HIST1H2BC,H2AFJ,REC8,HIST1H2BD,HIST1H2AJ,SYNE1,SYCP3,HIST3H2BB,HIST1H2BK,HIST1H4A"]
["DNA Damage/Telomere Stress Induced Senescence",{"v":1.47080453007795E-4,"d":"1.471E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.576090552999238,"d":"0.576"},{"v":2.12118135077078,"d":"2.121"},0,40,"TERF1,H2AFX,H2AFZ,HIST1H2BL,HIST2H2AC,HIST1H2BH,TERF2IP,TERF2,HIST2H2BE,HIST1H2BN,UBN1,TINF2,HIRA,HIST1H2BC,H2AFJ,HIST1H1C,HIST1H2BD,HIST1H2AJ,HIST3H2BB,HIST1H2BK,HIST1H4A"]
["DNA Double Strand Break Response",{"v":1.47080453007795E-4,"d":"1.471E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.571211896822313,"d":"0.571"},{"v":2.10321800378403,"d":"2.103"},0,40,"H2AFX,HIST1H2BL,HIST1H2BH,UBE2V2,RPS27A,BAZ1B,HIST2H2BE,BRCA1,HIST1H2BN,MDC1,UIMC1,SMARCA5,HIST1H2BC,PIAS4,HIST1H2BD,ABL1,KPNA2,HIST3H2BB,UBB,HERC2,HIST1H2BK,HIST1H4A"]
["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks",{"v":1.48104265402844E-4,"d":"1.481E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.564633972190883,"d":"0.565"},{"v":2.06542763759323,"d":"2.065"},0,39,"H2AFX,HIST1H2BL,HIST1H2BH,UBE2V2,RPS27A,BAZ1B,HIST2H2BE,BRCA1,HIST1H2BN,MDC1,UIMC1,SMARCA5,HIST1H2BC,PIAS4,HIST1H2BD,ABL1,HIST3H2BB,UBB,HERC2,HIST1H2BK,HIST1H4A"]
["Complex I biogenesis",{"v":1.48765248437965E-4,"d":"1.488E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.746923611230743,"d":"0.747"},{"v":2.70196239672626,"d":"2.702"},0,37,"NDUFA8,NDUFB8,NDUFAF1,NDUFA2,NDUFC1,NDUFB6,NDUFA5,NDUFB2,NDUFB7,TIMMDC1,NDUFS1,NDUFA11,NDUFS2,NDUFB4,NDUFS8,NDUFA10,NDUFA6,NDUFB5,NDUFAF4,NDUFAF3,NDUFAF5,NDUFS5,NDUFB3,NDUFA3,NDUFS7,NDUFS3,NDUFAF2,ACAD9,NDUFS6"]
["ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression",{"v":1.49231457991345E-4,"d":"1.492E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.603511820063439,"d":"0.604"},{"v":2.15650714113114,"d":"2.157"},0,35,"H2AFX,H2AFZ,HIST1H2BL,HIST2H2AC,HIST1H2BH,H3F3A,HIST1H3A,GATAD2A,HIST2H2BE,MTA1,HDAC1,HIST1H2BN,HIST1H2BC,H2AFJ,HIST1H2BD,HIST1H2AJ,HIST3H2BB,HIST1H2BK,HIST1H4A"]
["Meiotic recombination",{"v":1.49231457991345E-4,"d":"1.492E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.584905682255326,"d":"0.585"},{"v":2.12373071772022,"d":"2.124"},0,38,"H2AFX,H2AFZ,HIST1H2BL,HIST2H2AC,HIST1H2BH,H3F3A,HIST1H3A,HIST2H2BE,BRCA1,HIST1H2BN,CDK4,HIST1H2BC,BRCA2,H2AFJ,HIST1H2BD,HIST1H2AJ,HIST3H2BB,HIST1H2BK,HIST1H4A"]
["Nonhomologous End-Joining (NHEJ)",{"v":1.50784077201448E-4,"d":"1.508E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.624222600410181,"d":"0.624"},{"v":2.20961193723801,"d":"2.210"},0,34,"H2AFX,HIST1H2BL,HIST1H2BH,UBE2V2,HIST2H2BE,BRCA1,TDP2,HIST1H2BN,MDC1,UIMC1,LIG4,HIST1H2BC,PIAS4,HIST1H2BD,PAXIP1,HIST3H2BB,HERC2,HIST1H2BK,HIST1H4A"]
["PRC2 methylates histones and DNA",{"v":1.51423379769836E-4,"d":"1.514E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.656352340760907,"d":"0.656"},{"v":2.26538615037905,"d":"2.265"},0,30,"H2AFX,H2AFZ,HIST1H2BL,HIST2H2AC,HIST1H2BH,EED,H3F3A,HIST1H3A,HIST2H2BE,HIST1H2BN,HIST1H2BC,H2AFJ,HIST1H2BD,SUZ12,HIST1H2AJ,HIST3H2BB,HIST1H2BK,HIST1H4A,EZH2,H2AFV"]
["Condensation of Prophase Chromosomes",{"v":1.51584053357587E-4,"d":"1.516E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.662051772938932,"d":"0.662"},{"v":2.2657220404028,"d":"2.266"},0,29,"H2AFX,H2AFZ,HIST1H2BL,HIST2H2AC,HIST1H2BH,H3F3A,HIST1H3A,HIST2H2BE,SET,HIST1H2BN,HIST1H2BC,H2AFJ,NCAPG2,HIST1H2BD,HIST1H2AJ,MCPH1,HIST3H2BB,HIST1H2BK,HIST1H4A,SMC4,H2AFV"]
["Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3",{"v":1.51998784009728E-4,"d":"1.520E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.696023810450049,"d":"0.696"},{"v":2.31732590683344,"d":"2.317"},0,26,"H2AFX,H2AFZ,HIST1H2BL,HIST2H2AC,HIST1H2BH,H3F3A,HIST1H3A,HIST2H2BE,HIST1H2BN,KLK2,KDM4C,HIST1H2BC,H2AFJ,HIST1H2BD,HIST1H2AJ,HIST3H2BB,HIST1H2BK,HIST1H4A"]
["SIRT1 negatively regulates rRNA expression",{"v":1.5220700152207E-4,"d":"1.522E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.686936626952848,"d":"0.687"},{"v":2.32750077060187,"d":"2.328"},0,28,"TAF1D,H2AFX,H2AFZ,HIST1H2BL,HIST2H2AC,HIST1H2BH,H3F3A,HIST1H3A,HIST2H2BE,HIST1H2BN,HIST1H2BC,H2AFJ,HIST1H2BD,HIST1H2AJ,HIST3H2BB,TAF1B,HIST1H2BK,HIST1H4A,SIRT1,H2AFV,TAF1C"]
["DNA methylation",{"v":1.53586238673015E-4,"d":"1.536E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.638181707238374,"d":"0.638"},{"v":2.09797594577752,"d":"2.098"},0,25,"H2AFX,H2AFZ,HIST1H2BL,HIST2H2AC,HIST1H2BH,H3F3A,HIST1H3A,HIST2H2BE,HIST1H2BN,HIST1H2BC,H2AFJ,HIST1H2BD,HIST1H2AJ,HIST3H2BB,HIST1H2BK,HIST1H4A"]
["Packaging Of Telomere Ends",{"v":1.53917192550408E-4,"d":"1.539E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.73297353096417,"d":"0.733"},{"v":2.38680032543934,"d":"2.387"},0,24,"TERF1,H2AFX,H2AFZ,HIST1H2BL,HIST2H2AC,HIST1H2BH,TERF2IP,TERF2,HIST2H2BE,HIST1H2BN,TINF2,HIST1H2BC,H2AFJ,HIST1H2BD,HIST1H2AJ,HIST3H2BB,HIST1H2BK,HIST1H4A"]
["Resolution of D-loop Structures through Holliday Junction Intermediates",{"v":1.53917192550408E-4,"d":"1.539E-04"},{"v":0.0029423836642553,"d":"2.942E-03"},{"v":0.639287847176471,"d":"0.639"},{"v":2.08172925382868,"d":"2.082"},0,24,"EXO1,BRIP1,WRN,SLX4,XRCC3,BRCA1,RAD51D,BRCA2,EME2,RAD51B,RMI2,MUS81,XRCC2"]
["GTP hydrolysis and joining of the 60S ribosomal subunit",{"v":2.74725274725275E-4,"d":"2.747E-04"},{"v":0.00483598954380639,"d":"4.836E-03"},{"v":0.476444130349972,"d":"0.476"},{"v":1.95373339057175,"d":"1.954"},1,71,"RPL27A,RPL6,RPL34,RPL36AL,RPS3,RPS3A,EIF3J,RPS27A,RPS7,RPS8,RPL32,RPL8,RPS27L,RPL14,RPL24,EIF4H,RPL7,RPL7A,RPL30,RPL19,RPS15A,RPL35,EIF3L,RPL37,RPS19,EIF2S2,EIF3E,RPL18A"]
["L13a-mediated translational silencing of Ceruloplasmin expression",{"v":2.74725274725275E-4,"d":"2.747E-04"},{"v":0.00483598954380639,"d":"4.836E-03"},{"v":0.468315626684061,"d":"0.468"},{"v":1.92040119479927,"d":"1.920"},1,71,"RPL27A,RPL6,RPL34,RPL36AL,RPS3,RPS3A,EIF3J,RPS27A,RPS7,RPS8,RPL32,RPL8,RPS27L,RPL14,RPL24,EIF4H,RPL7,RPL7A,RPL30,RPL19,RPS15A,RPL35,EIF3L,RPL37,RPS19,EIF2S2,EIF3E,RPL18A"]
["HATs acetylate histones",{"v":2.74914089347079E-4,"d":"2.749E-04"},{"v":0.00483598954380639,"d":"4.836E-03"},{"v":0.464226118349277,"d":"0.464"},{"v":1.9078887027926,"d":"1.908"},1,72,"HIST1H2BL,HIST2H2AC,HIST1H2BH,MORF4L1,HIST1H3A,HIST2H2BE,ELP5,HIST1H2BN,MBIP,SUPT20H,HIST1H2BC,HIST1H2BD,EPC1,MEAF6,SUPT7L,KAT7,HIST1H2AG,HIST1H2AJ,TAF5L,HIST3H2A,NCOA1,CREBBP,HIST3H2BB,HIST2H2BF,HIST1H2BK,HIST1H4A,VPS72,TADA2A,DR1,MSL1,KAT6A,YEATS2,KANSL3,ELP2,ING5,ING3,YEATS4,TAF10,BRD8,HAT1,HIST1H2BM,DMAP1,ZZZ3,KAT5,BRPF1,HIST2H2AA3"]
["Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)",{"v":2.74914089347079E-4,"d":"2.749E-04"},{"v":0.00483598954380639,"d":"4.836E-03"},{"v":0.464873021737784,"d":"0.465"},{"v":1.91054736334173,"d":"1.911"},1,72,"RPL27A,RPL6,RPL34,RPL36AL,RPS3,RPS3A,RPS27A,RNPS1,RPS7,RPS8,SMG5,UPF3A,RPL32,RPL8,RPS27L,RPL14,RPL24,RPL7,RPL7A,RPL30,RPL19,RPS15A,RPL35"]
["Nonsense-Mediated Decay (NMD)",{"v":2.74914089347079E-4,"d":"2.749E-04"},{"v":0.00483598954380639,"d":"4.836E-03"},{"v":0.464873021737784,"d":"0.465"},{"v":1.91054736334173,"d":"1.911"},1,72,"RPL27A,RPL6,RPL34,RPL36AL,RPS3,RPS3A,RPS27A,RNPS1,RPS7,RPS8,SMG5,UPF3A,RPL32,RPL8,RPS27L,RPL14,RPL24,RPL7,RPL7A,RPL30,RPL19,RPS15A,RPL35"]
["NoRC negatively regulates rRNA expression",{"v":2.81412691712396E-4,"d":"2.814E-04"},{"v":0.00483598954380639,"d":"4.836E-03"},{"v":0.496103542531649,"d":"0.496"},{"v":1.96709117696166,"d":"1.967"},1,59,"TAF1D,H2AFX,H2AFZ,TWISTNB,HIST1H2BL,HIST2H2AC,HIST1H2BH,H3F3A,POLR1E,HIST1H3A,HIST2H2BE,SIN3A,HDAC1,HIST1H2BN,SMARCA5,HIST1H2BC,H2AFJ,HIST1H2BD,HIST1H2AJ,SAP30,SUDS3,ARID4B,HIST3H2BB,TAF1B,CCNH,HIST1H2BK,HIST1H4A,H2AFV,CD3EAP,TAF1C"]
["Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)",{"v":2.82485875706215E-4,"d":"2.825E-04"},{"v":0.00483598954380639,"d":"4.836E-03"},{"v":0.495133254249576,"d":"0.495"},{"v":1.9502845896149,"d":"1.950"},1,57,"RPL27A,RPL6,RPL34,RPL36AL,RPS3,RPS3A,RPS27A,RPS7,RPS8,RPL32,RPL8,RPS27L,RPL14,RPL24,RPL7,RPL7A,RPL30,RPL19,RPS15A,RPL35"]
["Resolution of D-Loop Structures",{"v":3.0717247734603E-4,"d":"3.072E-04"},{"v":0.0051812769340573,"d":"5.181E-03"},{"v":0.627897510982108,"d":"0.628"},{"v":2.06416739858385,"d":"2.064"},1,25,"EXO1,BRIP1,WRN,SLX4,XRCC3,BRCA1,RAD51D,BRCA2,EME2,RAD51B,RMI2,MUS81,XRCC2"]
["Transcriptional Regulation by E2F6",{"v":3.13185092389602E-4,"d":"3.132E-04"},{"v":0.00520613479667933,"d":"5.206E-03"},{"v":0.637318701188348,"d":"0.637"},{"v":2.02504727028005,"d":"2.025"},1,22,"EHMT1,YAF2,EED,BRCA1,MAX,TFDP2,E2F1,TFDP1,SUZ12,EPC1"]
["Epigenetic regulation of gene expression",{"v":4.04639870515241E-4,"d":"4.046E-04"},{"v":0.0061701166243491,"d":"6.170E-03"},{"v":0.464339322256377,"d":"0.464"},{"v":1.97283473810457,"d":"1.973"},2,87,"TAF1D,H2AFX,DDX21,H2AFZ,TWISTNB,HIST1H2BL,HIST2H2AC,HIST1H2BH,EED,BAZ1B,H3F3A,POLR1E,HIST1H3A,GATAD2A,HIST2H2BE,SIN3A,MTA1,HDAC1,HIST1H2BN,SMARCA5,MYO1C,HIST1H2BC,H2AFJ,HIST1H2BD,SUZ12,HIST1H2AJ,SAP30,SUDS3,ARID4B,HIST3H2BB,TAF1B,CCNH,HIST1H2BK,HIST1H4A,SIRT1,EZH2,H2AFV,CD3EAP,TAF1C"]
["Cap-dependent Translation Initiation",{"v":4.0821880527963E-4,"d":"4.082E-04"},{"v":0.0061701166243491,"d":"6.170E-03"},{"v":0.44516889863536,"d":"0.445"},{"v":1.8537785475396,"d":"1.854"},2,77,"RPL27A,RPL6,RPL34,RPL36AL,RPS3,RPS3A,EIF4EBP1,EIF3J,RPS27A,RPS7,RPS8,RPL32,RPL8,RPS27L,RPL14,RPL24,EIF4H,RPL7,RPL7A,RPL30,RPL19,RPS15A,RPL35,EIF3L,RPL37,RPS19,EIF2S2,EIF3E,RPL18A"]
["Eukaryotic Translation Initiation",{"v":4.0821880527963E-4,"d":"4.082E-04"},{"v":0.0061701166243491,"d":"6.170E-03"},{"v":0.44516889863536,"d":"0.445"},{"v":1.8537785475396,"d":"1.854"},2,77,"RPL27A,RPL6,RPL34,RPL36AL,RPS3,RPS3A,EIF4EBP1,EIF3J,RPS27A,RPS7,RPS8,RPL32,RPL8,RPS27L,RPL14,RPL24,EIF4H,RPL7,RPL7A,RPL30,RPL19,RPS15A,RPL35,EIF3L,RPL37,RPS19,EIF2S2,EIF3E,RPL18A"]
["Selenoamino acid metabolism",{"v":4.08775037471045E-4,"d":"4.088E-04"},{"v":0.0061701166243491,"d":"6.170E-03"},{"v":0.445703669090338,"d":"0.446"},{"v":1.8654576335591,"d":"1.865"},2,80,"RPL27A,RPL6,RPL34,RPL36AL,RPS3,RPS3A,RPS27A,RPS7,RPS8,AIMP2,AHCY,RPL32,RPL8,RPS27L,HNMT,RPL14,GSR,RPL24,RPL7,RPL7A,RPL30,SEPHS2,RPL19,RPS15A,RPL35,EEF1E1,RPL37,RPS19,PAPSS1,RPL18A"]
["Influenza Infection",{"v":4.08830744071954E-4,"d":"4.088E-04"},{"v":0.0061701166243491,"d":"6.170E-03"},{"v":0.438438411316451,"d":"0.438"},{"v":1.83060667326378,"d":"1.831"},2,79,"RPL27A,RPL6,RPL34,RPL36AL,RPS3,CPSF4,RPS3A,RPS27A,RPS7,RPS8,TGFB1,RPL32,RPL8,RPS27L,RPL14,RPL24,RPL7,RPL7A,RPL30,RPL19,RPS15A,KPNA2,RPL35"]
["HDR through Homologous Recombination (HRR)",{"v":4.26015336552116E-4,"d":"4.260E-04"},{"v":0.0062646101413497,"d":"6.265E-03"},{"v":0.496300257561904,"d":"0.496"},{"v":1.93196210806278,"d":"1.932"},2,53,"EXO1,BRIP1,WRN,RAD9A,HUS1,POLE4,POLE3,RAD1,RPS27A,SLX4,XRCC3,BRCA1,RAD51D,BRCA2,EME2,POLE2,RAD51B,RMI2,UBB,MUS81,XRCC2"]
["Influenza Viral RNA Transcription and Replication",{"v":5.51267916207277E-4,"d":"5.513E-04"},{"v":0.00794535920366304,"d":"7.945E-03"},{"v":0.434906925284568,"d":"0.435"},{"v":1.77758792985492,"d":"1.778"},3,70,"RPL27A,RPL6,RPL34,RPL36AL,RPS3,RPS3A,RPS27A,RPS7,RPS8,RPL32,RPL8,RPS27L,RPL14,RPL24,RPL7,RPL7A,RPL30,RPL19,RPS15A,RPL35"]
["Regulation of TP53 Activity through Phosphorylation",{"v":5.54554276999861E-4,"d":"5.546E-04"},{"v":0.00794535920366304,"d":"7.945E-03"},{"v":0.451956498913927,"d":"0.452"},{"v":1.82738151655999,"d":"1.827"},3,66,"EXO1,BRIP1,WRN,CDK5,TAF3,RAD9A,HUS1,STK11,RAD1,TAF4,RPS27A,BRCA1,PIN1,PRKAB1,TAF13,NOC2L,SSRP1,RMI2,UBB"]
["Chromosome Maintenance",{"v":5.64971751412429E-4,"d":"5.650E-04"},{"v":0.00794535920366304,"d":"7.945E-03"},{"v":0.468481877435116,"d":"0.468"},{"v":1.84530725463053,"d":"1.845"},3,57,"TERF1,H2AFX,H2AFZ,HIST1H2BL,HIST2H2AC,POLE4,HIST1H2BH,POLE3,CENPO,TERF2IP,LIG1,TERF2,HIST2H2BE,HIST1H2BN,SMARCA5,TINF2,HIST1H2BC,H2AFJ,HIST1H2BD,POLE2,HIST1H2AJ,HIST3H2BB,FEN1,HIST1H2BK,HIST1H4A"]
["Amyloid fiber formation",{"v":5.68020448736154E-4,"d":"5.680E-04"},{"v":0.00794535920366304,"d":"7.945E-03"},{"v":0.491497725779273,"d":"0.491"},{"v":1.91326715619555,"d":"1.913"},3,53,"H2AFX,H2AFZ,HIST1H2BL,HIST2H2AC,HIST1H2BH,RPS27A,H3F3A,HIST1H3A,HIST2H2BE,GGA1,HIST1H2BN,SAA1,BACE1,HIST1H2BC,APCS,HIST1H2BD,NAT8,PRL,HIST1H2AJ,SIAH1,HIST3H2BB,UBB,APOA1,HIST1H2BK,HIST1H4A,IAPP,ITM2B"]
["Transcriptional regulation by RUNX1",{"v":6.18658747834694E-4,"d":"6.187E-04"},{"v":0.00854941667188427,"d":"8.549E-03"},{"v":0.362859972103702,"d":"0.363"},{"v":1.67692771378361,"d":"1.677"},4,156,"PSME3,H2AFX,H2AFZ,HIST1H2BL,HIST2H2AC,YAF2,HIST1H2BH,PSMF1,RPS27A,ELF2,SETD1A,H3F3A,HIST1H3A,HIST2H2BE,CR1,SMARCD1,SIN3A,HDAC1,HIST1H2BN,PSMB10,DPY30,HIST1H2BC,PSME2,PF4,AGO2,H2AFJ,ARID1A,HIST1H2BD,PSMB6,CDK6,KMT2C,ARID1B,SMARCE1,GP1BA,ABL1,AGO1,HIST1H2AJ,CTSV,CREBBP,HIST3H2BB,UBB,PSMC2,CCND1,TCF3,MYB,HIST1H2BK,SOCS4,HIST1H4A,PSMB9,PHC2,TP73,KMT2D,H2AFV,TJP1,SPI1,KMT2E,IL2,NFATC2"]
["Regulation of TP53 Activity",{"v":6.49013499480789E-4,"d":"6.490E-04"},{"v":0.00886212480838649,"d":"8.862E-03"},{"v":0.393023015108064,"d":"0.393"},{"v":1.74331358683392,"d":"1.743"},4,114,"EXO1,BRIP1,EHMT1,WRN,CDK5,TAF3,RAD9A,CCNG1,HUS1,STK11,RAD1,TAF4,RPS27A,RFFL,GATAD2A,BRCA1,DAXX,HDAC1,PIN1,PRKAB1,JMY,MEAF6,TAF13,NOC2L,SSRP1,RMI2"]
["TP53 Regulates Metabolic Genes",{"v":7.06214689265537E-4,"d":"7.062E-04"},{"v":0.00952974410103024,"d":"9.530E-03"},{"v":0.465753605773939,"d":"0.466"},{"v":1.83456084216195,"d":"1.835"},4,57,"TSC2,YWHAE,RRAGA,COX5A,COX4I1,YWHAG,CYCS,PRKAB1,TSC1,AGO2,NDUFA4,GSR,DDIT4,COX7C,COX5B,SCO2,YWHAZ,COX7A2L,AGO1"]
["Mitochondrial protein import",{"v":7.53920386007238E-4,"d":"7.539E-04"},{"v":0.0100551939854686,"d":"1.006E-02"},{"v":0.562100965023023,"d":"0.562"},{"v":1.95270503383891,"d":"1.953"},4,31,"NDUFB8,COX17,CHCHD3,CS,MTX1,COQ2,CYC1,TIMM22,LDHD,TIMM17A,CMC2,COA6,DNAJC19"]
["Cristae formation",{"v":0.00117311882017764,"d":"1.173E-03"},{"v":0.0154662906522271,"d":"1.547E-02"},{"v":0.705106799884034,"d":"0.705"},{"v":1.89100524120768,"d":"1.891"},6,12,"CHCHD3,ATP5I,MINOS1,MTX1,ATP5L"]
["Phosphorylation of the APC/C",{"v":0.00123915737298637,"d":"1.239E-03"},{"v":0.0161512898501746,"d":"1.615E-02"},{"v":-0.711113988184666,"d":"-0.711"},{"v":-2.07603551521991,"d":"-2.076"},4,12,"ANAPC10,ANAPC11,CCNB1,CDC16,UBE2D1,ANAPC2"]
["Fanconi Anemia Pathway",{"v":0.00126522220464969,"d":"1.265E-03"},{"v":0.0163057288621707,"d":"1.631E-02"},{"v":0.632179148800979,"d":"0.632"},{"v":1.95636628651263,"d":"1.956"},7,20,"WDR48,FANCG,RPS27A,FANCA,FANCL,SLX4,FANCC,EME2,POLN,UBB,MUS81"]
["Cellular Senescence",{"v":0.00143024314133403,"d":"1.430E-03"},{"v":0.0182276542567792,"d":"1.823E-02"},{"v":0.372879100404146,"d":"0.373"},{"v":1.65015762483516,"d":"1.650"},10,112,"TERF1,EHMT1,H2AFX,H2AFZ,HIST1H2BL,HIST2H2AC,HIST1H2BH,EED,RPS27A,TERF2IP,H3F3A,HIST1H3A,TERF2,HIST2H2BE,HIST1H2BN,UBN1,TINF2,CDK4,HIRA,TFDP2,E2F1,HIST1H2BC,TFDP1,H2AFJ,HIST1H1C,HIST1H2BD,CDK6,SUZ12,AGO1,HIST1H2AJ,HIST3H2BB,UBB,E2F3,MINK1,HIST1H2BK,HIST1H4A"]
["Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)",{"v":0.00158152775581211,"d":"1.582E-03"},{"v":0.0199342014935879,"d":"1.993E-02"},{"v":0.622506130295347,"d":"0.623"},{"v":1.92643178562135,"d":"1.926"},9,20,"EXO1,BRIP1,WRN,XRCC3,BRCA1,RAD51D,BRCA2,RAD51B,RMI2,XRCC2"]
["Regulation of IFNA signaling",{"v":0.00174381737476221,"d":"1.744E-03"},{"v":0.0210799386446692,"d":"2.108E-02"},{"v":0.619529971020616,"d":"0.620"},{"v":1.89213440008458,"d":"1.892"},10,19,"IFNA4,IFNA1,IFNA17,SOCS1,IFNA5,IFNA8"]
["mRNA decay by 5' to 3' exoribonuclease",{"v":0.00177981184846173,"d":"1.780E-03"},{"v":0.0210799386446692,"d":"2.108E-02"},{"v":-0.680175341883749,"d":"-0.680"},{"v":-2.03255805436835,"d":"-2.033"},6,13,"LSM7,EDC4,XRN1,PATL1,LSM6,LSM5,EDC3,DDX6,DCP2,LSM2"]
["Influenza Life Cycle",{"v":0.00178694158075601,"d":"1.787E-03"},{"v":0.0210799386446692,"d":"2.108E-02"},{"v":0.418220615157983,"d":"0.418"},{"v":1.71881407658013,"d":"1.719"},12,72,"RPL27A,RPL6,RPL34,RPL36AL,RPS3,RPS3A,RPS27A,RPS7,RPS8,RPL32,RPL8,RPS27L,RPL14,RPL24,RPL7,RPL7A,RPL30,RPL19,RPS15A,RPL35"]
["Homologous DNA Pairing and Strand Exchange",{"v":0.00180940892641737,"d":"1.809E-03"},{"v":0.0210799386446692,"d":"2.108E-02"},{"v":0.515479075814237,"d":"0.515"},{"v":1.82468356411175,"d":"1.825"},11,34,"EXO1,BRIP1,WRN,RAD9A,HUS1,RAD1,XRCC3,BRCA1,RAD51D,BRCA2,RAD51B,RMI2"]
["Activation of HOX genes during differentiation",{"v":0.00181945416375087,"d":"1.819E-03"},{"v":0.0210799386446692,"d":"2.108E-02"},{"v":0.432284754182221,"d":"0.432"},{"v":1.73264157086808,"d":"1.733"},12,63,"H2AFX,H2AFZ,HIST1H2BL,HIST2H2AC,HIST1H2BH,EED,YY1,H3F3A,HIST1H3A,PAGR1,HIST2H2BE,HIST1H2BN,HIST1H2BC,H2AFJ,HIST1H2BD,SUZ12,KMT2C,PAXIP1,HIST1H2AJ,CREBBP,HIST3H2BB,HIST1H2BK,HIST1H4A,EZH2,RARA,KMT2D,H2AFV,AJUBA,HOXA1,HOXA3"]
["Activation of anterior HOX genes in hindbrain development during early embryogenesis",{"v":0.00181945416375087,"d":"1.819E-03"},{"v":0.0210799386446692,"d":"2.108E-02"},{"v":0.432284754182221,"d":"0.432"},{"v":1.73264157086808,"d":"1.733"},12,63,"H2AFX,H2AFZ,HIST1H2BL,HIST2H2AC,HIST1H2BH,EED,YY1,H3F3A,HIST1H3A,PAGR1,HIST2H2BE,HIST1H2BN,HIST1H2BC,H2AFJ,HIST1H2BD,SUZ12,KMT2C,PAXIP1,HIST1H2AJ,CREBBP,HIST3H2BB,HIST1H2BK,HIST1H4A,EZH2,RARA,KMT2D,H2AFV,AJUBA,HOXA1,HOXA3"]
["Signaling by cytosolic FGFR1 fusion mutants",{"v":0.00218892069371948,"d":"2.189E-03"},{"v":0.0248583369870915,"d":"2.486E-02"},{"v":0.711821256291998,"d":"0.712"},{"v":1.86484629810404,"d":"1.865"},12,11,"STAT5A,FGFR1OP,GAB2,MYO18A,ZMYM2"]
["TRAF6 mediated IRF7 activation",{"v":0.00235923246303869,"d":"2.359E-03"},{"v":0.0265298003441704,"d":"2.653E-02"},{"v":0.593731338308621,"d":"0.594"},{"v":1.86401614662524,"d":"1.864"},14,21,"IFNA4,IFNA1,IFNA17,IRF7,DDX58,IFNA5,IFNA8,CREBBP"]
["Estrogen-dependent gene expression",{"v":0.00240770465489567,"d":"2.408E-03"},{"v":0.0268120120307314,"d":"2.681E-02"},{"v":0.379828647220612,"d":"0.380"},{"v":1.63207171166373,"d":"1.632"},17,94,"H2AFX,H2AFZ,CCNT1,HIST1H2BL,HIST2H2AC,HIST1H2BH,POU2F1,JUND,YY1,H3F3A,HIST1H3A,HIST2H2BE,HDAC1,HIST1H2BN,CHD1,HIST1H2BC,AGO2,H2AFJ,HIST1H2BD,AGO1,FKBP4,HIST1H2AJ,USF2,KPNA2,NCOA1,CREBBP,HIST3H2BB,CCND1,MYB,HIST1H2BK,HIST1H4A"]
["Mitochondrial biogenesis",{"v":0.00250036770113252,"d":"2.500E-03"},{"v":0.0275761707038365,"d":"2.758E-02"},{"v":0.48613540462978,"d":"0.486"},{"v":1.78996400632083,"d":"1.790"},16,40,"CHCHD3,ATP5I,MINOS1,SOD2,MTX1,CYCS,ATP5L,PRKAB1,GABPB1,TFAM,ESRRA,ATP5B,POLG2,SIRT3,CREB1,MAPK11,ATP5J2,TFB2M"]
["Presynaptic phase of homologous DNA pairing and strand exchange",{"v":0.00256139822208829,"d":"2.561E-03"},{"v":0.0279802262927169,"d":"2.798E-02"},{"v":0.516684579482375,"d":"0.517"},{"v":1.80574302599585,"d":"1.806"},16,32,"EXO1,BRIP1,WRN,RAD9A,HUS1,RAD1,BRCA1,RAD51D,BRCA2,RAD51B,RMI2,XRCC2"]
["Translocation of ZAP-70 to Immunological synapse",{"v":0.00286234712464221,"d":"2.862E-03"},{"v":0.0303070759157971,"d":"3.031E-02"},{"v":-0.6533318448695,"d":"-0.653"},{"v":-1.98920736207948,"d":"-1.989"},10,14,"CD247,ZAP70,HLA-DQA2,CD3G,HLA-DPA1,PTPN22,HLA-DRB5,CD3D,HLA-DRA"]
["PKMTs methylate histone lysines",{"v":0.00288009701379415,"d":"2.880E-03"},{"v":0.0303070759157971,"d":"3.031E-02"},{"v":0.529214921643641,"d":"0.529"},{"v":1.8111180440697,"d":"1.811"},18,29,"EHMT1,EED,SETD1A,HIST1H3A,SETDB1,DPY30,SUZ12,KMT2C,SETD2,SMYD2,HIST1H4A,EZH2,KMT2D,KMT2E,DOT1L"]
["Cell Cycle",{"v":0.0029673590504451,"d":"2.967E-03"},{"v":0.0309414620987321,"d":"3.094E-02"},{"v":0.277270749024726,"d":"0.277"},{"v":1.40744001433008,"d":"1.407"},26,394,"EXO1,TERF1,BRIP1,PSME3,KNTC1,WRN,H2AFX,ZWILCH,RAD9A,H2AFZ,DYRK1A,YWHAE,HIST1H2BL,HIST2H2AC,HUS1,CLSPN,FKBPL,ZW10,POLE4,HIST1H2BH,POLE3,RAD1,CENPO,MAPRE1,FGFR1OP,PSMF1,FKBP6,UBE2V2,RPS27A,TERF2IP,CEP63,RFWD2,CEP152,LIG1,H3F3A,HIST1H3A,CEP192,TERF2,HIST2H2BE,BRCA1,YWHAG,SET,GORASP1,HDAC1,MAU2,HIST1H2BN,MDC1,CEP135,UIMC1,SMARCA5,ARPP19,TINF2,MAX,PSMB10,CDK4,TFDP2,E2F1,HIST1H2BC,TFDP1,PSME2,BRCA2,H2AFJ,BLZF1,NIPBL,REC8,PIAS4,NCAPG2,HIST1H2BD,PSMB6,CEP41,CDK6,POLE2,LYN,CEP78,CDC20,TUBB4B,YWHAZ,ABL1,RBL2,HIST1H2AJ,SKP2,NCAPG,RMI2,SYNE1,PPP1CC,SYCP3,PRKAR2B,ORC6,MCPH1,HIST3H2BB,UBB,FEN1,CENPJ,E2F3,PSMC2,CCND1,CEP250,HERC2,LCMT1,ZWINT,CCNH,HIST1H2BK,SKA2,HIST1H4A,ORC2,PSMB9"]
["DNA strand elongation",{"v":0.00313837375178317,"d":"3.138E-03"},{"v":0.0315764446780289,"d":"3.158E-02"},{"v":-0.527284476442631,"d":"-0.527"},{"v":-1.89016607047108,"d":"-1.890"},10,24,"MCM6,GINS4,GINS1,RFC5,POLD2,MCM5,MCM3,RFC2,POLA2,RPA1,POLD1"]
["G2/M Checkpoints",{"v":0.00339958158995816,"d":"3.400E-03"},{"v":0.0337712174224543,"d":"3.377E-02"},{"v":0.362835884217347,"d":"0.363"},{"v":1.59845783653511,"d":"1.598"},25,109,"EXO1,BRIP1,PSME3,WRN,H2AFX,RAD9A,YWHAE,HIST1H2BL,HUS1,CLSPN,HIST1H2BH,RAD1,PSMF1,UBE2V2,RPS27A,HIST2H2BE,BRCA1,YWHAG,HIST1H2BN,MDC1,UIMC1,PSMB10,HIST1H2BC,PSME2,PIAS4,HIST1H2BD,PSMB6,YWHAZ,RMI2,ORC6,HIST3H2BB,UBB,PSMC2,HERC2,HIST1H2BK,HIST1H4A,ORC2,PSMB9"]
["Senescence-Associated Secretory Phenotype (SASP)",{"v":0.00341539775152981,"d":"3.415E-03"},{"v":0.0337712174224543,"d":"3.377E-02"},{"v":0.451645349654911,"d":"0.452"},{"v":1.7421393279783,"d":"1.742"},23,50,"EHMT1,H2AFX,H2AFZ,HIST1H2BL,HIST2H2AC,HIST1H2BH,RPS27A,H3F3A,HIST1H3A,HIST2H2BE,HIST1H2BN,CDK4,HIST1H2BC,H2AFJ,HIST1H2BD,CDK6,HIST1H2AJ,HIST3H2BB,UBB,HIST1H2BK,HIST1H4A"]
["Citric acid cycle (TCA cycle)",{"v":0.00350039777247414,"d":"3.500E-03"},{"v":0.0343158653421183,"d":"3.432E-02"},{"v":0.608780818020891,"d":"0.609"},{"v":1.83479273097152,"d":"1.835"},21,18,"SDHD,CS,SDHA,FH,DLD,SDHB,SUCLG1,NNT,OGDH,SDHC,DLST"]
["Metalloprotease DUBs",{"v":0.00385294589821801,"d":"3.853E-03"},{"v":0.0374519402140344,"d":"3.745E-02"},{"v":0.622361415410885,"d":"0.622"},{"v":1.81800121378569,"d":"1.818"},23,16,"HIST2H2AC,RPS27A,BRCA1,UIMC1,STAMBP,HIST1H2AG,HIST1H2AJ,HIST3H2A,UBB"]
["Deubiquitination",{"v":0.00401606425702811,"d":"4.016E-03"},{"v":0.0387094596874894,"d":"3.871E-02"},{"v":0.321388770384445,"d":"0.321"},{"v":1.50960492319302,"d":"1.510"},32,181,"UCHL3,WDR48,PSME3,HIST1H2BL,HIST2H2AC,CLSPN,HIST1H2BH,INO80B,KEAP1,SMAD1,PSMF1,RPS27A,YY1,TNIP3,TGFB1,HIST2H2BE,BRCA1,BAP1,INO80E,KDM1B,HIST1H2BN,UCHL5,UIMC1,DDX58,SMAD3,PSMB10,USP17L2,TNKS,HIST1H2BC,PSME2,HIST1H2BD,PSMB6,USP21,ASXL1,ACTR8,CDC20,STAMBP,HIST1H2AG,HIST1H2AJ,SKP2,USP4,ACTR5,BECN1,HIST3H2A,SUDS3,NFRKB,HIST3H2BB,IDE,UBB,HIST2H2BF,PSMC2,USP16"]
["Interferon alpha/beta signaling",{"v":0.00451530972202625,"d":"4.515E-03"},{"v":0.042802150836067,"d":"4.280E-02"},{"v":0.432234468540039,"d":"0.432"},{"v":1.69852389247236,"d":"1.699"},31,56,"IFNA4,IFNA1,IFNA17,IRF4,ISG20,IRF5,IRF7,SOCS1,SAMHD1,IRF6,IRF9,IFNA5,MX1,IFNA8,IRF1,IRF8"]
["Protein ubiquitination",{"v":0.00469951580746226,"d":"4.700E-03"},{"v":0.04375,"d":"4.375E-02"},{"v":0.44840315614996,"d":"0.448"},{"v":1.7226288428333,"d":"1.723"},32,49,"UCHL3,HIST1H2BL,RRAGA,HIST1H2BH,UBE2V2,RPS27A,HIST1H2BN,HIST1H2BC,UBE2W,UBE2R2,RNF40,HIST1H2BD,WDR61,UBB,WAC,SHPRH,HIST1H2BK"]
["rRNA modification in the nucleus and cytosol",{"v":0.00498414136837336,"d":"4.984E-03"},{"v":0.0457344811961939,"d":"4.573E-02"},{"v":0.493826320471132,"d":"0.494"},{"v":1.73569488430566,"d":"1.736"},32,33,"THUMPD1,WDR46,HEATR1,GAR1,BMS1,RPS7,WDR75,NOL6,RRP36,WDR3,NOP10"]
["Inactivation of APC/C via direct inhibition of the APC/C complex",{"v":0.0053394355453852,"d":"5.339E-03"},{"v":0.0482230911067467,"d":"4.822E-02"},{"v":-0.636500302209572,"d":"-0.637"},{"v":-1.90204457027357,"d":"-1.902"},20,13,"ANAPC10,MAD2L1,ANAPC11,CDC16,UBE2D1,ANAPC2"]
["Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components",{"v":0.0053394355453852,"d":"5.339E-03"},{"v":0.0482230911067467,"d":"4.822E-02"},{"v":-0.636500302209572,"d":"-0.637"},{"v":-1.90204457027357,"d":"-1.902"},20,13,"ANAPC10,MAD2L1,ANAPC11,CDC16,UBE2D1,ANAPC2"]
["E3 ubiquitin ligases ubiquitinate target proteins",{"v":0.0055043141922047,"d":"5.504E-03"},{"v":0.0493238154567093,"d":"4.932E-02"},{"v":0.477748451733279,"d":"0.478"},{"v":1.72823342610699,"d":"1.728"},36,37,"HIST1H2BL,RRAGA,HIST1H2BH,UBE2V2,RPS27A,HIST1H2BN,HIST1H2BC,RNF40,HIST1H2BD,WDR61,UBB,WAC,SHPRH,HIST1H2BK"]
["Gamma carboxylation, hypusine formation and arylsulfatase activation",{"v":0.00568269083090155,"d":"5.683E-03"},{"v":0.050527491341427,"d":"5.053E-02"},{"v":0.532464565027687,"d":"0.532"},{"v":1.75043852986798,"d":"1.750"},36,25,"ARSI,DPH2,F7,DPH7,ICMT,DHPS,DPH5,ARSA,DPH1,GAS6,SUMF2"]
["PD-1 signaling",{"v":0.00574412532637076,"d":"5.744E-03"},{"v":0.0506808596103635,"d":"5.068E-02"},{"v":-0.594713191417333,"d":"-0.595"},{"v":-1.85980570337557,"d":"-1.860"},21,15,"PDCD1LG2,CD247,HLA-DQA2,CD3G,HLA-DPA1,HLA-DRB5,CD3D,HLA-DRA"]
["Glyoxylate metabolism and glycine degradation",{"v":0.0061434495469206,"d":"6.143E-03"},{"v":0.0537903559566254,"d":"5.379E-02"},{"v":0.525601961710556,"d":"0.526"},{"v":1.72787822059955,"d":"1.728"},39,25,"LIPT1,LIAS,AGXT,GOT2,DLAT,PRODH2,DLD,GCSH,BCKDHB,OGDH,AGXT2,GLDC,DLST"]
["ESR-mediated signaling",{"v":0.00650816841546022,"d":"6.508E-03"},{"v":0.0565520391858551,"d":"5.655E-02"},{"v":0.361672723256086,"d":"0.362"},{"v":1.56577250902224,"d":"1.566"},48,98,"H2AFX,H2AFZ,CCNT1,HIST1H2BL,HIST2H2AC,HIST1H2BH,POU2F1,JUND,YY1,H3F3A,HIST1H3A,HIST2H2BE,HDAC1,HIST1H2BN,CHD1,HIST1H2BC,AGO2,H2AFJ,HIST1H2BD,AGO1,FKBP4,HIST1H2AJ,USF2,KPNA2,NCOA1,CREBBP,HIST3H2BB,CCND1,MYB,HIST1H2BK,HIST1H4A"]
["HDR through Single Strand Annealing (SSA)",{"v":0.00700152207001522,"d":"7.002E-03"},{"v":0.0603815474759959,"d":"6.038E-02"},{"v":0.50705622117672,"d":"0.507"},{"v":1.71802419498632,"d":"1.718"},45,28,"EXO1,BRIP1,WRN,RAD9A,HUS1,RAD1,BRCA1,ABL1,RMI2"]
["RNA Polymerase III Chain Elongation",{"v":0.00713758306669948,"d":"7.138E-03"},{"v":0.060643020574106,"d":"6.064E-02"},{"v":-0.658850974017742,"d":"-0.659"},{"v":-1.86723192989655,"d":"-1.867"},28,11,"POLR3B,POLR3A,POLR2K,POLR3D,POLR2F"]
["RNA Polymerase III Transcription Termination",{"v":0.00713758306669948,"d":"7.138E-03"},{"v":0.060643020574106,"d":"6.064E-02"},{"v":-0.658850974017742,"d":"-0.659"},{"v":-1.86723192989655,"d":"-1.867"},28,11,"POLR3B,POLR3A,POLR2K,POLR3D,POLR2F"]
["Mitotic Spindle Checkpoint",{"v":0.00728332119446468,"d":"7.283E-03"},{"v":0.0614262456621396,"d":"6.143E-02"},{"v":-0.339173494685575,"d":"-0.339"},{"v":-1.58626417871354,"d":"-1.586"},19,70,"PPP2R5A,ANAPC10,DYNC1I2,MAD2L1,ANAPC11,CDC16,AHCTF1,SEC13,PPP2R5D,NUP98,CENPC,CENPL,UBE2D1,CENPM,NSL1,ANAPC2,PPP2R5E,CKAP5,NUP160,CENPK,SEH1L,PAFAH1B1,ANAPC5,KIF18A,PMF1,TAOK1,SPDL1,CENPT,XPO1,MIS12,CLIP1"]
["Deposition of new CENPA-containing nucleosomes at the centromere",{"v":0.00770276393294064,"d":"7.703E-03"},{"v":0.0637525585846405,"d":"6.375E-02"},{"v":0.487616659493314,"d":"0.488"},{"v":1.71386924167449,"d":"1.714"},50,33,"H2AFX,H2AFZ,HIST1H2BL,HIST2H2AC,HIST1H2BH,CENPO,HIST2H2BE,HIST1H2BN,SMARCA5,HIST1H2BC,H2AFJ,HIST1H2BD,HIST1H2AJ,HIST3H2BB,HIST1H2BK,HIST1H4A"]
["Nucleosome assembly",{"v":0.00770276393294064,"d":"7.703E-03"},{"v":0.0637525585846405,"d":"6.375E-02"},{"v":0.487616659493314,"d":"0.488"},{"v":1.71386924167449,"d":"1.714"},50,33,"H2AFX,H2AFZ,HIST1H2BL,HIST2H2AC,HIST1H2BH,CENPO,HIST2H2BE,HIST1H2BN,SMARCA5,HIST1H2BC,H2AFJ,HIST1H2BD,HIST1H2AJ,HIST3H2BB,HIST1H2BK,HIST1H4A"]
["Mitotic Prophase",{"v":0.00804773137227695,"d":"8.048E-03"},{"v":0.0659339134571548,"d":"6.593E-02"},{"v":0.395147326961843,"d":"0.395"},{"v":1.60434790616836,"d":"1.604"},57,68,"H2AFX,H2AFZ,HIST1H2BL,HIST2H2AC,HIST1H2BH,H3F3A,HIST1H3A,HIST2H2BE,SET,GORASP1,HIST1H2BN,ARPP19,HIST1H2BC,H2AFJ,BLZF1,NCAPG2,HIST1H2BD,HIST1H2AJ,MCPH1,HIST3H2BB,HIST1H2BK,HIST1H4A,SMC4,H2AFV,GOLGA2"]
["Platelet homeostasis",{"v":0.00889046941678521,"d":"8.890E-03"},{"v":0.0718124536693847,"d":"7.181E-02"},{"v":-0.337377699266433,"d":"-0.337"},{"v":-1.56629751307186,"d":"-1.566"},24,67,"PPP2R5A,PLA2G4A,TRPC3,ATP2A2,PPP2R5D,PRKG1,NOS1,PDE1B,GNG12,PDE1A,GUCY1B3,PPP2R5E,TRPC6,ITPR2,GNG7,P2RX5,MRVI1,TRPC7,GNGT2,GNG3"]
["Signaling by Nuclear Receptors",{"v":0.0092851691681506,"d":"9.285E-03"},{"v":0.0739589516379773,"d":"7.396E-02"},{"v":0.336336397510048,"d":"0.336"},{"v":1.5193883674206,"d":"1.519"},72,129,"H2AFX,H2AFZ,CCNT1,HIST1H2BL,HIST2H2AC,RDH10,HIST1H2BH,POU2F1,DLAT,JUND,YY1,H3F3A,HIST1H3A,HIST2H2BE,DLD,HDAC1,HIST1H2BN,CHD1,CPT1B,FABP5,HIST1H2BC,AGO2,H2AFJ,HIST1H2BD,DHRS4,AGO1,FKBP4,HIST1H2AJ,USF2,KPNA2,NCOA1,RDH13,CREBBP,HIST3H2BB,CCND1,MYB,HIST1H2BK,HIST1H4A"]
["Regulation of expression of SLITs and ROBOs",{"v":0.00951264008339849,"d":"9.513E-03"},{"v":0.0750327593714289,"d":"7.503E-02"},{"v":0.343316423148156,"d":"0.343"},{"v":1.51537921656173,"d":"1.515"},72,110,"PSME3,RPL27A,RPL6,RPL34,RPL36AL,RPS3,RPS3A,PSMF1,RPS27A,RNPS1,RPS7,RPS8,UPF3A,RPL32,PSMB10,RPL8,PSME2,RPS27L,PSMB6,RPL14,CUL2,RPL24,RPL7,RPL7A,RPL30,RPL19,RPS15A,LHX4,RPL35,UBB,PSMC2,RPL37,RPS19,PSMB9"]
["RMTs methylate histone arginines",{"v":0.00955081331144605,"d":"9.551E-03"},{"v":0.0750327593714289,"d":"7.503E-02"},{"v":0.469238489306388,"d":"0.469"},{"v":1.67671306417237,"d":"1.677"},63,35,"H2AFX,H2AFZ,HIST2H2AC,HIST1H3A,SMARCD1,CDK4,H2AFJ,ARID1A,ARID1B,SMARCE1,HIST1H2AG,HIST1H2AJ,HIST3H2A,CCND1,HIST1H4A,H2AFV,PRMT7"]
["Organelle biogenesis and maintenance",{"v":0.00997755051134946,"d":"9.978E-03"},{"v":0.0778520437858356,"d":"7.785E-02"},{"v":0.323265433094275,"d":"0.323"},{"v":1.48437212765606,"d":"1.484"},79,148,"INPP5E,PKD1,YWHAE,RAB11FIP3,CHCHD3,ATP5I,MINOS1,SOD2,MAPRE1,FGFR1OP,CEP63,CEP152,CEP192,MTX1,ARL13B,YWHAG,CYCS,CEP135,ATP5L,PRKAB1,GABPB1,TFAM,ESRRA,BBS9,CEP41,IFT80,CEP78,ATP5B,TUBB4B,EXOC3,ARF4,POLG2,PRKAR2B,CENPJ,SIRT3,IFT140,EXOC7,CEP250"]
["Phosphorylation of CD3 and TCR zeta chains",{"v":0.0101631452259963,"d":"1.016E-02"},{"v":0.078764375501471,"d":"7.876E-02"},{"v":-0.546135559318121,"d":"-0.546"},{"v":-1.7754805323887,"d":"-1.775"},37,17,"PTPRC,CD247,HLA-DQA2,CD3G,HLA-DPA1,PTPN22,HLA-DRB5,CD3D,HLA-DRA"]
["Intrinsic Pathway for Apoptosis",{"v":0.0109024833434282,"d":"1.090E-02"},{"v":0.0828155522841866,"d":"8.282E-02"},{"v":0.483774484232882,"d":"0.484"},{"v":1.66973734750062,"d":"1.670"},71,30,"YWHAE,BAX,YWHAG,CYCS,CASP8,TFDP2,E2F1,TFDP1,YWHAZ"]
["Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase",{"v":0.0119698152485038,"d":"1.197E-02"},{"v":0.0903248558554857,"d":"9.032E-02"},{"v":-0.582131570775319,"d":"-0.582"},{"v":-1.77242302725418,"d":"-1.772"},45,14,"ANAPC10,ANAPC11,CDC16,UBE2D1,ANAPC2"]
["RUNX1 regulates transcription of genes involved in differentiation of HSCs",{"v":0.0121278941565601,"d":"1.213E-02"},{"v":0.0909195725331662,"d":"9.092E-02"},{"v":0.380536322429138,"d":"0.381"},{"v":1.55535985815542,"d":"1.555"},87,70,"PSME3,H2AFX,H2AFZ,HIST1H2BL,HIST2H2AC,HIST1H2BH,PSMF1,RPS27A,H3F3A,HIST1H3A,HIST2H2BE,HIST1H2BN,PSMB10,HIST1H2BC,PSME2,H2AFJ,HIST1H2BD,PSMB6,ABL1,HIST1H2AJ,HIST3H2BB,UBB,PSMC2,TCF3,MYB,HIST1H2BK,HIST1H4A,PSMB9,TP73,H2AFV,SPI1"]
["Nucleobase biosynthesis",{"v":0.0123396655301185,"d":"1.234E-02"},{"v":0.0919064698899088,"d":"9.191E-02"},{"v":0.60461099665165,"d":"0.605"},{"v":1.70233490438301,"d":"1.702"},75,14,"IMPDH2,PAICS,ATIC,PPAT,ADSS,UMPS,GMPS,DHODH,ADSL,GART,IMPDH1,CAD"]
["Protein folding",{"v":0.0131578947368421,"d":"1.316E-02"},{"v":0.0971375338753388,"d":"9.714E-02"},{"v":-0.327845663048629,"d":"-0.328"},{"v":-1.522044426235,"d":"-1.522"},36,67,"TUBAL3,TBCD,CCT3,FBXW10,CSNK2A2,CCT2,GNAZ,FBXL5,RGS9,GNG12,TBCE,TUBA1A,TUBA8,TUBA1B,GNAT2,GNG7,CCNE2,GNGT2,RGS6,GNG3"]

{"sheet":"S2E. KRAS GSEA","index":4,"n_rows":43,"n_cols":8,"rows_kept":43}
["S2E. Significantly enriched pathways for KRAS CDE genes (FDR<0.1) with GSEA analysis"]
["The sign of ES and NES scores represents the direction of enrichment (positive values represent pathways enriched by CDE+ genes, negative values represent those enriched by CDE- genes). The table is sorted by adjusted p value and p value."]
[]
["pathway","p value","p adjusted","enrichment score","normalized enrichment score","# more extreme","pathway size","leading edge genes"]
["DNA Repair",{"v":1.76025347650062E-4,"d":"1.760E-04"},{"v":0.0137637157771386,"d":"1.376E-02"},{"v":-0.37620307442508,"d":"-0.376"},{"v":-1.97854128157059,"d":"-1.979"},0,246,"UBE2B,LIG4,LIG1,PALB2,RMI1,XRCC2,MDC1,LIG3,GEN1,REV3L,NHEJ1,RFC4,CCNA1,RFC3,PMS2,PARP1,ERCC8,POLK,POLN,PIAS1,UBA52,PNKP,XRCC4,HIST1H2BD,OGG1,HERC2,RIF1,BRIP1,POLQ,TDG,RAD1,EME1,DCLRE1B,BRCA2,SUMO2,RNF168,RBBP8,SLX4,MSH2,HIST1H2BB,HUS1,UBE2I,RAD51,TP53BP1,COPS4,HIST2H2BE,MAD2L2,HIST1H2BL,MNAT1,ERCC1,RAD17,H2AFX,PPP4R2,XRCC5,POLM,TOPBP1,RBX1,EYA3,CDK2,XRCC6,HIST1H2BC,RMI2,RAD51B,RPA1,EXO1,POLD1,HIST1H2BJ,ASCC2,MBD4,GPS1,UIMC1,KPNA2,BAZ1B,POLR2F,RHNO1,ERCC4,RFC1,TDP2,CHD1L,UBE2V2,ASCC1,POLE3,POLR2H,ASCC3,SPRTN,COPS3,POLR2G,BARD1,XRCC3,TCEA1,BLM,ERCC3,RAD51D,SMARCA5,SMUG1,PRPF19,UBA7,ZBTB32,EYA2,NBN,MUS81,WRN,RNF8,USP7,UBE2L6,HMGN1,USP1,POLR2K,CCNH,RAD50,POLD3"]
["DNA Double-Strand Break Repair",{"v":1.7860332202179E-4,"d":"1.786E-04"},{"v":0.0137637157771386,"d":"1.376E-02"},{"v":-0.510789794471825,"d":"-0.511"},{"v":-2.46640434517787,"d":"-2.466"},0,133,"LIG4,PALB2,RMI1,XRCC2,MDC1,LIG3,GEN1,NHEJ1,RFC4,CCNA1,RFC3,PARP1,POLK,UBA52,XRCC4,HIST1H2BD,HERC2,RIF1,BRIP1,POLQ,RAD1,EME1,BRCA2,SUMO2,RNF168,RBBP8,SLX4,HIST1H2BB,HUS1,UBE2I,RAD51,TP53BP1,HIST2H2BE,HIST1H2BL,ERCC1,RAD17,H2AFX,PPP4R2,XRCC5,POLM,TOPBP1,EYA3,CDK2,XRCC6,HIST1H2BC,RMI2,RAD51B,RPA1,EXO1,POLD1,HIST1H2BJ,UIMC1,KPNA2,BAZ1B,RHNO1,ERCC4,RFC1,TDP2,UBE2V2,POLE3,BARD1,XRCC3,BLM,RAD51D,SMARCA5,EYA2,NBN,MUS81,WRN,RNF8"]
["Homology Directed Repair",{"v":1.79985601151908E-4,"d":"1.800E-04"},{"v":0.0137637157771386,"d":"1.376E-02"},{"v":-0.500761315563287,"d":"-0.501"},{"v":-2.33390111710188,"d":"-2.334"},0,107,"PALB2,RMI1,XRCC2,MDC1,LIG3,GEN1,RFC4,CCNA1,RFC3,PARP1,POLK,UBA52,HIST1H2BD,HERC2,BRIP1,POLQ,RAD1,EME1,BRCA2,SUMO2,RNF168,RBBP8,SLX4,HIST1H2BB,HUS1,UBE2I,RAD51,TP53BP1,HIST2H2BE,HIST1H2BL,ERCC1,RAD17,H2AFX,PPP4R2,TOPBP1,CDK2,HIST1H2BC,RMI2,RAD51B,RPA1,EXO1,POLD1,HIST1H2BJ,UIMC1,RHNO1,ERCC4,RFC1,UBE2V2,POLE3,BARD1,XRCC3,BLM,RAD51D,NBN,MUS81,WRN,RNF8"]
["HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)",{"v":1.80538003249684E-4,"d":"1.805E-04"},{"v":0.0137637157771386,"d":"1.376E-02"},{"v":-0.494695568067397,"d":"-0.495"},{"v":-2.28657823473834,"d":"-2.287"},0,102,"PALB2,RMI1,XRCC2,MDC1,GEN1,RFC4,CCNA1,RFC3,POLK,UBA52,HIST1H2BD,HERC2,BRIP1,RAD1,EME1,BRCA2,SUMO2,RNF168,RBBP8,SLX4,HIST1H2BB,HUS1,UBE2I,RAD51,TP53BP1,HIST2H2BE,HIST1H2BL,ERCC1,RAD17,H2AFX,PPP4R2,TOPBP1,CDK2,HIST1H2BC,RMI2,RAD51B,RPA1,EXO1,POLD1,HIST1H2BJ,UIMC1,RHNO1,ERCC4,RFC1,UBE2V2,POLE3,BARD1,XRCC3,BLM,RAD51D,NBN,MUS81,WRN,RNF8"]
["HDR through Homologous Recombination (HRR)",{"v":1.82149362477231E-4,"d":"1.821E-04"},{"v":0.0137637157771386,"d":"1.376E-02"},{"v":-0.525306342431895,"d":"-0.525"},{"v":-2.20960973273495,"d":"-2.210"},0,61,"PALB2,RMI1,XRCC2,GEN1,RFC4,RFC3,POLK,UBA52,BRIP1,RAD1,EME1,BRCA2,RBBP8,SLX4,HUS1,RAD51,RAD17,TOPBP1,RMI2,RAD51B,RPA1,EXO1,POLD1,RHNO1,RFC1,POLE3,BARD1,XRCC3,BLM,RAD51D,NBN,MUS81,WRN,RAD50,POLD3"]
["Processing of DNA double-strand break ends",{"v":1.82949140139041E-4,"d":"1.829E-04"},{"v":0.0137637157771386,"d":"1.376E-02"},{"v":-0.491008358544031,"d":"-0.491"},{"v":-2.12099820083509,"d":"-2.121"},0,71,"RMI1,MDC1,RFC4,CCNA1,RFC3,UBA52,HIST1H2BD,HERC2,BRIP1,RAD1,SUMO2,RNF168,RBBP8,HIST1H2BB,HUS1,UBE2I,TP53BP1,HIST2H2BE,HIST1H2BL,RAD17,H2AFX,PPP4R2,TOPBP1,CDK2,HIST1H2BC,RMI2,RPA1,EXO1,HIST1H2BJ,UIMC1,RHNO1,UBE2V2"]
["Respiratory electron transport",{"v":1.82949140139041E-4,"d":"1.829E-04"},{"v":0.0137637157771386,"d":"1.376E-02"},{"v":-0.444514681576783,"d":"-0.445"},{"v":-1.92016046868292,"d":"-1.920"},0,71,"SDHC,SDHD,SDHB,COX5A,NDUFAF5,NDUFB7,NDUFS3,COX6A1,NDUFA11,NUBPL,UQCRC2,COX6C,UQCRC1,NDUFB3,NDUFA9,NDUFS1,UQCRFS1,SDHA,UQCRQ,NDUFB6,CYCS,NDUFB9,NDUFA3,NDUFAF1,NDUFB2,CYC1,NDUFA4,NDUFS2,UQCRB,NDUFAF6,NDUFB10,COX6B1,NDUFS5,NDUFA10,COX4I1,NDUFC1,NDUFAB1,NDUFV1,NDUFB8,UQCR10,NDUFS4,UQCRH,NDUFA8,NDUFA6,NDUFS7"]
["G2/M DNA damage checkpoint",{"v":1.83016105417277E-4,"d":"1.830E-04"},{"v":0.0137637157771386,"d":"1.376E-02"},{"v":-0.459416990369132,"d":"-0.459"},{"v":-1.9760187676163,"d":"-1.976"},0,69,"RMI1,MDC1,YWHAZ,RFC4,RFC3,HIST1H2BD,HERC2,BRIP1,RAD1,RNF168,RBBP8,YWHAB,HIST1H2BB,HUS1,TP53BP1,HIST2H2BE,HIST1H2BL,RAD17,H2AFX,TOPBP1,HIST1H2BC,RMI2,RPA1,EXO1,HIST1H2BJ,UIMC1,RHNO1,UBE2V2,CDC25C,BARD1,BLM,NBN,WRN,RNF8,RAD50,HIST1H2BA,CDK1,UBE2N,WEE1,HIST1H2BM"]
["Nonhomologous End-Joining (NHEJ)",{"v":1.8450184501845E-4,"d":"1.845E-04"},{"v":0.0137637157771386,"d":"1.376E-02"},{"v":-0.55520630725751,"d":"-0.555"},{"v":-2.17702703411615,"d":"-2.177"},0,44,"LIG4,MDC1,NHEJ1,XRCC4,HIST1H2BD,HERC2,RIF1,RNF168,HIST1H2BB,TP53BP1,HIST2H2BE,HIST1H2BL,H2AFX,XRCC5,POLM,XRCC6,HIST1H2BC,HIST1H2BJ,UIMC1,TDP2,UBE2V2,BARD1,NBN,RNF8,RAD50,HIST1H2BA,UBE2N,HIST1H2BM"]
["DNA Double Strand Break Response",{"v":1.8470631695604E-4,"d":"1.847E-04"},{"v":0.0137637157771386,"d":"1.376E-02"},{"v":-0.456134063919909,"d":"-0.456"},{"v":-1.85594059974636,"d":"-1.856"},0,52,"MDC1,UBA52,HIST1H2BD,HERC2,RNF168,HIST1H2BB,UBE2I,TP53BP1,HIST2H2BE,HIST1H2BL,H2AFX,EYA3,HIST1H2BC,HIST1H2BJ,UIMC1,KPNA2,BAZ1B,UBE2V2,BARD1,SMARCA5,EYA2,NBN,RNF8,RAD50,HIST1H2BA,UBE2N,HIST1H2BM"]
["Homologous DNA Pairing and Strand Exchange",{"v":1.85839063371121E-4,"d":"1.858E-04"},{"v":0.0137637157771386,"d":"1.376E-02"},{"v":-0.572918173754918,"d":"-0.573"},{"v":-2.17820178521313,"d":"-2.178"},0,39,"PALB2,RMI1,XRCC2,RFC4,RFC3,BRIP1,RAD1,BRCA2,RBBP8,HUS1,RAD51,RAD17,TOPBP1,RMI2,RAD51B,RPA1,EXO1,RHNO1,BARD1,XRCC3,BLM,RAD51D,NBN,WRN"]
["Resolution of D-loop Structures through Holliday Junction Intermediates",{"v":1.86915887850467E-4,"d":"1.869E-04"},{"v":0.0137637157771386,"d":"1.376E-02"},{"v":-0.660438980248328,"d":"-0.660"},{"v":-2.31897454097925,"d":"-2.319"},0,28,"PALB2,RMI1,XRCC2,GEN1,BRIP1,EME1,BRCA2,RBBP8,SLX4,RAD51,RMI2,RAD51B,EXO1,BARD1,XRCC3,BLM,RAD51D,NBN,MUS81,WRN,RAD50"]
["Resolution of D-Loop Structures",{"v":1.88005264147396E-4,"d":"1.880E-04"},{"v":0.0137637157771386,"d":"1.376E-02"},{"v":-0.646209490179883,"d":"-0.646"},{"v":-2.28732449237591,"d":"-2.287"},0,29,"PALB2,RMI1,XRCC2,GEN1,BRIP1,EME1,BRCA2,RBBP8,SLX4,RAD51,RMI2,RAD51B,EXO1,BARD1,XRCC3,BLM,RAD51D,NBN,MUS81,WRN,RAD50"]
["Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)",{"v":1.89143181388311E-4,"d":"1.891E-04"},{"v":0.0137637157771386,"d":"1.376E-02"},{"v":-0.652074281982072,"d":"-0.652"},{"v":-2.1961899862508,"d":"-2.196"},0,24,"PALB2,RMI1,XRCC2,BRIP1,BRCA2,RBBP8,RAD51,RMI2,RAD51B,EXO1,BARD1,XRCC3,BLM,RAD51D,NBN,WRN,RAD50"]
["Nucleobase biosynthesis",{"v":1.89609404626469E-4,"d":"1.896E-04"},{"v":0.0137637157771386,"d":"1.376E-02"},{"v":-0.779135660725051,"d":"-0.779"},{"v":-2.30747797782904,"d":"-2.307"},0,15,"ADSL,IMPDH2,DHODH,GMPS,GART,PAICS,PPAT,PFAS,ATIC,UMPS,CAD,ADSS"]
["Purine ribonucleoside monophosphate biosynthesis",{"v":1.91754554170662E-4,"d":"1.918E-04"},{"v":0.0137637157771386,"d":"1.376E-02"},{"v":-0.788797098223485,"d":"-0.789"},{"v":-2.17556558576662,"d":"-2.176"},0,12,"ADSL,IMPDH2,GMPS,GART,PAICS,PPAT,PFAS,ATIC"]
["The citric acid (TCA) cycle and respiratory electron transport",{"v":3.57653791130186E-4,"d":"3.577E-04"},{"v":0.0208902614516468,"d":"2.089E-02"},{"v":-0.36572636619456,"d":"-0.366"},{"v":-1.755749698041,"d":"-1.756"},1,129,"SDHC,PDPR,SUCLA2,SDHD,SDHB,COX5A,ME1,NDUFAF5,NDUFB7,NDUFS3,COX6A1,VDAC1,NDUFA11,ATP5J,NUBPL,DLST,UQCRC2,COX6C,UQCRC1,OGDH,DLD,FH,ADHFE1,IDH3B,ATP5O,NDUFB3,NDUFA9,NDUFS1,UQCRFS1,SDHA,PDP2,IDH3A,UQCRQ,ME2,NDUFB6,PDHA2,CYCS,NDUFB9,SLC16A3,IDH2,ACO2,CS,NDUFA3,NDUFAF1,NDUFB2,PDK1,CYC1,NDUFA4,NDUFS2,UQCRB,NDUFAF6,NDUFB10,COX6B1,NDUFS5,ATP5F1,PDP1,NDUFA10,COX4I1,ATP5L,UCP3"]
["E3 ubiquitin ligases ubiquitinate target proteins",{"v":3.6941263391208E-4,"d":"3.694E-04"},{"v":0.0208902614516468,"d":"2.089E-02"},{"v":-0.443124010195669,"d":"-0.443"},{"v":-1.80300465651907,"d":"-1.803"},1,52,"UBE2B,LEO1,RNF152,UBA52,UBE2D2,HIST1H2BD,RNF20,SHPRH,RTF1,UBE2D3,UBE2J2,HIST1H2BB,PEX2,HIST1H2BL,HIST1H2BC,HIST1H2BJ,CTR9,PAF1,UBE2V2,CDC73,RNF40,RRAGA,UBE2L3,PEX13,PEX5,PEX12,PEX10,HIST1H2BA,UBE2N,HIST1H2BM"]
["Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks",{"v":3.69617445943449E-4,"d":"3.696E-04"},{"v":0.0208902614516468,"d":"2.089E-02"},{"v":-0.449773488849068,"d":"-0.450"},{"v":-1.82435067031289,"d":"-1.824"},1,51,"MDC1,UBA52,HIST1H2BD,HERC2,RNF168,HIST1H2BB,UBE2I,TP53BP1,HIST2H2BE,HIST1H2BL,H2AFX,EYA3,HIST1H2BC,HIST1H2BJ,UIMC1,BAZ1B,UBE2V2,BARD1,SMARCA5,EYA2,NBN,RNF8,RAD50,HIST1H2BA,UBE2N,HIST1H2BM"]
["Presynaptic phase of homologous DNA pairing and strand exchange",{"v":3.71885459278542E-4,"d":"3.719E-04"},{"v":0.0208902614516468,"d":"2.089E-02"},{"v":-0.562493093697836,"d":"-0.562"},{"v":-2.09871146668764,"d":"-2.099"},1,36,"RMI1,XRCC2,RFC4,RFC3,BRIP1,RAD1,BRCA2,RBBP8,HUS1,RAD51,RAD17,TOPBP1,RMI2,RAD51B,RPA1,EXO1,RHNO1,BARD1,BLM,RAD51D,NBN,WRN"]
["RNA Polymerase II Transcription",{"v":4.69777638584403E-4,"d":"4.698E-04"},{"v":0.0229056354009077,"d":"2.291E-02"},{"v":-0.223473512419369,"d":"-0.223"},{"v":-1.33940234225397,"d":"-1.339"},2,1094,"ELF2,RNMT,TAF13,ZNF75A,TCF7L2,ZNF12,ZNF519,BLK,ZNF730,ZNF266,JMY,CCNT2,ZNF253,CDC40,ZNF10,ZNF705A,NR1H2,ZNF33B,CNOT10,ZNF195,ZNF529,ZNF169,KMT2B,PSMB10,ZNF343,RMI1,TP53I3,LEO1,MDC1,YWHAZ,ZNF141,KAT6A,ZNF205,COX5A,SNRPG,ZNF418,RFC4,PITX2,SARNP,CENPJ,STK11,CCNA1,RFC3,ZNF677,PMS2,SUPT4H1,PARP1,NPM1,ELF1,PSMA8,SNRPD3,THOC5,UBA52,PRKAA2,ZNF431,SRRM1,ZNF263,TGIF1,NR1D1,HIST1H2BD,THOC6,ZNF470,ZNF790,ZNF416,AIFM2,ZNF226,GTF2E1,NCBP1,ZNF776,NFE2,ZNF546,TJP1,ZNF771,MED4,BRIP1,TFAP2D,TAF6,LAMTOR2,COX6A1,RTF1,ZFP28,PPP2R1B,GTF2B,RAD1,UBE2D3,NRBP1,PSME2,SETD1A,ITGBL1,ZNF600,SMAD4,ZNF655,ZC3H8,ZNF70,ITGA4,ZNF430,ZNF112,PSMF1,ZNF500,ELL3,RBBP8,CTNNB1,SP7,E2F8,YWHAB,WDR33,GPX2,BRPF1,CNOT6,PCF11,CDK13,MSH2,COX6C,MAX,ZC3H11A,PSME1,ZNF155,PSMD13,BCL2L14,FYTTD1,PSMD5,PSME3,MDM2,HIST1H2BB,PPP2R5C,ZFP30,ITGA2B,HUS1,ZNF28,BCL2L11,ZNF736,HIST1H2AB,PSMD6,ZNF713,UBE2I,RAD51,PF4,HIST2H2BE,SRC,PRDM7,DDX39A,CASP10,HIST1H2BL,TP53INP1,MNAT1,TSC1,RFFL,MAML3,NELFE,CSTF1,ZNF676,ZNF551,RAD17,SESN3,PHC1,H2AFX,CNOT11,ZNF320,TOPBP1,ZNF550,RBX1,RORA,CSTF3,ZNF383,AURKA,H2AFZ,RRAGC,RPRD1B,ZNF333,ZNF302,ARID2,TFDP1,ESR1,ZNF569,INTS4,RNGTT,CDK2,MED15,HIST1H2BC,ZNF19,RMI2,ZNF554,DDX39B,SMURF2,PSMD3,ZNF555,ZNF696,YAP1,E2F6,RPA1,ATF2,PPARGC1B,APAF1,RBL1,RRAGD,ZNF14,SRSF6,NUAK1,TAF9,SOCS4,EXO1,HEY1,RXRB,HDAC4,ZNF460,TAF11,HIST1H2BJ,YEATS4,MAPK14,CLP1,SNAPC3,SMARCA4,CCNT1,ZNF208,MBD3,RNPS1,PSMC4,ZNF432,PPM1A,ZNF282,ZNF234,RARG,CTR9,RUNX2,GTF2A2,ZNF596,DDIT4,ZNF267,ZFP14,PAF1,ZNF619,ZNF17,POLR2F,SMAD6,RHNO1,CCNC,CHTOP,TAF4,ZNF3,ZNF468,ZNF287,BRD7,ZNF613,PRR5,FOS,CYCS,CDC25C,ASH2L,ZNF124,MED30,USP2,TRIM33,POLR2H,ZNF689,ZNF324B,ZNF385A,MED16,ZNF692,NFATC2,CDC73,RRM2B,CDK8,ING5,ZNF79,GSK3B,TAF10,POLR2G,GP1BA,ZNF577,NABP2,GTF2F2,ZNF665,BARD1,KCTD6,MYB,RABGGTB,TSC2,YES1,ZNF562,YAF2,DAXX,ACTL6B,SRSF2,TCEA1,TEAD4,ZNF704,CNOT1,NOTCH4,ZNF420,TXN,ZNF625,MED10,BLM,ZNF461,ZKSCAN3,ZNF607,CNOT2,MED31,PSMA7,PRKAG2,HNF4G,RRAGA,CARM1,LSM10,ERCC3,SP1,ZKSCAN5,KMT2A,ZNF543,RAD51D,ZNF563,ZNF573,TBX5,KMT2E,HDAC3,SLC38A9,ELL,SMAD2,CDC7,CHD3,ZNF436,NBN,ZNF33A,ZNF586,TMEM219,LMO1,ZNF720,NDUFA4,BRD2,JAG1,GPI,WRN,RXRA,JUN,ZNF100,USP7,CNOT8,CSNK2A1,FAS,SUPT5H,NOP2,ZNF558,RPRD2,ZNF627,DLX5,ESRRB,ZNF615,MYL9,RBBP5,ZNF778,TAF7,MED23,POLR2K,CDK4,ZNF709,PSMB2,CCNH,GLS,MDM4,SRRT,SMARCB1,RAD50,UCMA,LMO2,PRMT1,MED24,PDPK1,KMT2D,ZNF37A,ZNF225,SMARCC1,ERCC2,HIST1H2BA,CDK1,COX6B1,DPY30,ZNF667,ZNF250,ZNF514,ZNF415,ZNF701,MOV10,TPX2"]
["Protein ubiquitination",{"v":5.4904831625183E-4,"d":"5.490E-04"},{"v":0.0229056354009077,"d":"2.291E-02"},{"v":-0.41028577425704,"d":"-0.410"},{"v":-1.76469831767974,"d":"-1.765"},2,69,"UBE2B,LEO1,RNF152,UBA52,UBE2D2,HIST1H2BD,UBE2Q2,RNF20,SHPRH,RTF1,UBE2D3,UBE2J2,HIST1H2BB,PEX2,HIST1H2BL,UBA6,UBE2E3,HIST1H2BC,HIST1H2BJ,CTR9,PAF1,UBE2V2,CDC73,UBE2Z,RNF40,RRAGA,UBE2L3,PEX13,PEX5,USP7,PEX12,PEX10,HIST1H2BA,UBE2N,HIST1H2BM,UBE2C,UBE2K,UBE2H,WDR61,HLTF,UCHL3"]
["Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.",{"v":5.52689756816507E-4,"d":"5.527E-04"},{"v":0.0229056354009077,"d":"2.291E-02"},{"v":-0.398872609306254,"d":"-0.399"},{"v":-1.77311360778328,"d":"-1.773"},2,83,"SDHC,SDHD,SDHB,COX5A,NDUFAF5,NDUFB7,NDUFS3,COX6A1,NDUFA11,ATP5J,NUBPL,UQCRC2,COX6C,UQCRC1,ATP5O,NDUFB3,NDUFA9,NDUFS1,UQCRFS1,SDHA,UQCRQ,NDUFB6,CYCS,NDUFB9,NDUFA3,NDUFAF1,NDUFB2,CYC1,NDUFA4,NDUFS2,UQCRB,NDUFAF6,NDUFB10,COX6B1,NDUFS5,ATP5F1,NDUFA10,COX4I1,ATP5L,UCP3,NDUFC1,NDUFAB1,NDUFV1,NDUFB8,UQCR10,NDUFS4,UQCRH,NDUFA8,NDUFA6,NDUFS7"]
["Complex I biogenesis",{"v":5.53505535055351E-4,"d":"5.535E-04"},{"v":0.0229056354009077,"d":"2.291E-02"},{"v":-0.473608420713628,"d":"-0.474"},{"v":-1.85707244676601,"d":"-1.857"},2,44,"NDUFAF5,NDUFB7,NDUFS3,NDUFA11,NUBPL,NDUFB3,NDUFA9,NDUFS1,NDUFB6,NDUFB9,NDUFA3,NDUFAF1,NDUFB2,NDUFS2,NDUFAF6,NDUFB10,NDUFS5,NDUFA10,NDUFC1,NDUFAB1,NDUFV1,NDUFB8,NDUFS4,NDUFA8,NDUFA6,NDUFS7,ACAD9,TIMMDC1,NDUFA13,NDUFB4,NDUFB5"]
["HDR through Single Strand Annealing (SSA)",{"v":5.57310050157905E-4,"d":"5.573E-04"},{"v":0.0229056354009077,"d":"2.291E-02"},{"v":-0.515455499907305,"d":"-0.515"},{"v":-1.90180666398958,"d":"-1.902"},2,34,"RMI1,RFC4,RFC3,BRIP1,RAD1,RBBP8,HUS1,RAD51,ERCC1,RAD17,TOPBP1,RMI2,RPA1,EXO1,RHNO1,ERCC4,BARD1,BLM,NBN,WRN"]
["Citric acid cycle (TCA cycle)",{"v":5.6732223903177E-4,"d":"5.673E-04"},{"v":0.0229056354009077,"d":"2.291E-02"},{"v":-0.631031278374276,"d":"-0.631"},{"v":-2.05338045075717,"d":"-2.053"},2,21,"SDHC,SUCLA2,SDHD,SDHB,DLST,OGDH,DLD,FH,IDH3B,SDHA,IDH3A,ME2,IDH2,ACO2,CS"]
["Pyruvate metabolism and Citric Acid (TCA) cycle",{"v":9.3179276928811E-4,"d":"9.318E-04"},{"v":0.0346450358651203,"d":"3.465E-02"},{"v":-0.44660553812474,"d":"-0.447"},{"v":-1.79952674451188,"d":"-1.800"},4,50,"SDHC,PDPR,SUCLA2,SDHD,SDHB,ME1,VDAC1,DLST,OGDH,DLD,FH,ADHFE1,IDH3B,SDHA,PDP2,IDH3A,ME2,PDHA2,SLC16A3,IDH2,ACO2,CS"]
["Class A/1 (Rhodopsin-like receptors)",{"v":9.38526513374003E-4,"d":"9.385E-04"},{"v":0.0346450358651203,"d":"3.465E-02"},{"v":0.279163120973895,"d":"0.279"},{"v":1.52493527919187,"d":"1.525"},3,278,"OPRD1,PTGIR,HCRT,HTR1A,LHCGR,KISS1,PTGER1,S1PR3,F2RL3,GALR2,HTR4,DRD2,RXFP3,GPR37,ADRB2,GPR183,INSL3,TSHR,ADRA1D,OXTR,ECE2,CXCL12,CX3CL1,CCR10,ADRB3,EDN3,TAAR8,CNR2,PTGFR,HRH1,RXFP1,FFAR3,GPR4,PRLHR,ADRA2C,LPAR1,HTR1D,P2RY13,PNOC,LHB,TAAR6,GALR1,SSTR3,GRP,XCL1,CCK,HTR5A,MTNR1B,NTSR1,HTR6,FSHB,FPR2,UTS2R,RRH,OPN3,CHRM2,MC3R,CCL20,KEL,TACR2,ADRB1,CXCL11,CNR1,CX3CR1,APLNR,CCKBR,EDNRB,HTR1E,TACR1,S1PR5,INSL5,CCR1,ADRA1B,GALR3,NMUR1,TAC1,TRH,RXFP4,AVPR1A,HTR2B,CXCR1,MLNR,AVPR1B,PTGER3,NTS,NMU,PENK,ACKR3,PTAFR,NPY2R,PTGDR"]
["Regulation of TP53 Activity through Phosphorylation",{"v":0.00110537951363301,"d":"1.105E-03"},{"v":0.0385986576111852,"d":"3.860E-02"},{"v":-0.390172644721364,"d":"-0.390"},{"v":-1.73443954184647,"d":"-1.734"},5,83,"TAF13,RMI1,RFC4,STK11,CCNA1,RFC3,UBA52,PRKAA2,BRIP1,TAF6,RAD1,RBBP8,MDM2,HUS1,TP53INP1,RAD17,TOPBP1,AURKA,CDK2,RMI2,RPA1,NUAK1,TAF9,EXO1,TAF11,MAPK14,RHNO1,TAF4,TAF10,BARD1,BLM,PRKAG2,NBN,WRN,CSNK2A1,TAF7,MDM4,RAD50"]
["Amine ligand-binding receptors",{"v":0.00151482363124865,"d":"1.515E-03"},{"v":0.0511830129443107,"d":"5.118E-02"},{"v":0.488971068257015,"d":"0.489"},{"v":1.8869427886932,"d":"1.887"},6,39,"HTR1A,HTR4,DRD2,ADRB2,ADRA1D,ADRB3,TAAR8,HRH1,ADRA2C,HTR1D,TAAR6,HTR5A,HTR6,CHRM2,ADRB1,HTR1E,ADRA1B,HTR2B"]
["Heme biosynthesis",{"v":0.00154499806875241,"d":"1.545E-03"},{"v":0.0511830129443107,"d":"5.118E-02"},{"v":-0.749272277727706,"d":"-0.749"},{"v":-1.95025210367745,"d":"-1.950"},7,10,"FECH,UROD,UROS,CPOX,COX15,PPOX,HMBS,COX10"]
["Transcriptional Regulation by TP53",{"v":0.0017164435290079,"d":"1.716E-03"},{"v":0.055441125986955,"d":"5.544E-02"},{"v":-0.264922704991644,"d":"-0.265"},{"v":-1.4360714152199,"d":"-1.436"},9,317,"TAF13,JMY,CCNT2,CNOT10,RMI1,TP53I3,MDC1,YWHAZ,KAT6A,COX5A,RFC4,CENPJ,STK11,CCNA1,RFC3,PMS2,SUPT4H1,NPM1,UBA52,PRKAA2,AIFM2,BRIP1,TAF6,LAMTOR2,COX6A1,PPP2R1B,RAD1,RBBP8,E2F8,YWHAB,GPX2,BRPF1,CNOT6,CDK13,MSH2,COX6C,BCL2L14,MDM2,PPP2R5C,HUS1,CASP10,TP53INP1,MNAT1,TSC1,RFFL,NELFE,RAD17,SESN3,CNOT11,TOPBP1,AURKA,RRAGC,TFDP1,CDK2,RMI2,RPA1,ATF2,APAF1,RBL1,RRAGD,NUAK1,TAF9,EXO1,TAF11,MAPK14,CCNT1,MBD3,DDIT4,POLR2F,RHNO1,TAF4,BRD7,PRR5,FOS,CYCS,CDC25C,USP2,POLR2H,ZNF385A,RRM2B,ING5,TAF10,POLR2G,GTF2F2,BARD1,RABGGTB,TSC2,DAXX,TCEA1,CNOT1,ZNF420,TXN,BLM,CNOT2,PRKAG2,RRAGA,CARM1,ERCC3,RAD51D,SLC38A9,ELL,CHD3,NBN,TMEM219,NDUFA4,GPI,WRN,JUN,USP7,CNOT8,CSNK2A1,FAS,SUPT5H,TAF7,POLR2K,CCNH,GLS,MDM4,RAD50,PRMT1,PDPK1,ERCC2,CDK1,COX6B1,MOV10,TPX2,RHEB"]
["Cobalamin (Cbl, vitamin B12) transport and metabolism",{"v":0.0018910741301059,"d":"1.891E-03"},{"v":0.0587507730364873,"d":"5.875E-02"},{"v":-0.578451678338862,"d":"-0.578"},{"v":-1.88228604304492,"d":"-1.882"},9,21,"ABCD4,MMAA,MMAB,MTRR,CUBN,CTRB1,CTRB2,ABCC1,MTR,PRSS3,PRSS1"]
["Methylation",{"v":0.00190985485103132,"d":"1.910E-03"},{"v":0.0587507730364873,"d":"5.875E-02"},{"v":-0.680552662583873,"d":"-0.681"},{"v":-1.93121651069249,"d":"-1.931"},9,13,"AHCY,CYP1A2,N6AMT1,MTRR,MAT1A,GSTO1,COMT,MTR"]
["Generic Transcription Pathway",{"v":0.00236183278223902,"d":"2.362E-03"},{"v":0.0678108434367291,"d":"6.781E-02"},{"v":-0.213624863257666,"d":"-0.214"},{"v":-1.27326402200041,"d":"-1.273"},14,988,"ELF2,TAF13,ZNF75A,TCF7L2,ZNF12,ZNF519,BLK,ZNF730,ZNF266,JMY,CCNT2,ZNF253,ZNF10,ZNF705A,NR1H2,ZNF33B,CNOT10,ZNF195,ZNF529,ZNF169,KMT2B,PSMB10,ZNF343,RMI1,TP53I3,MDC1,YWHAZ,ZNF141,KAT6A,ZNF205,COX5A,ZNF418,RFC4,PITX2,CENPJ,STK11,CCNA1,RFC3,ZNF677,PMS2,SUPT4H1,PARP1,NPM1,ELF1,PSMA8,UBA52,PRKAA2,ZNF431,ZNF263,TGIF1,NR1D1,HIST1H2BD,ZNF470,ZNF790,ZNF416,AIFM2,ZNF226,ZNF776,NFE2,ZNF546,TJP1,ZNF771,MED4,BRIP1,TFAP2D,TAF6,LAMTOR2,COX6A1,ZFP28,PPP2R1B,RAD1,UBE2D3,NRBP1,PSME2,SETD1A,ITGBL1,ZNF600,SMAD4,ZNF655,ZNF70,ITGA4,ZNF430,ZNF112,PSMF1,ZNF500,RBBP8,CTNNB1,SP7,E2F8,YWHAB,GPX2,BRPF1,CNOT6,CDK13,MSH2,COX6C,MAX,PSME1,ZNF155,PSMD13,BCL2L14,PSMD5,PSME3,MDM2,HIST1H2BB,PPP2R5C,ZFP30,ITGA2B,HUS1,ZNF28,BCL2L11,ZNF736,HIST1H2AB,PSMD6,ZNF713,UBE2I,RAD51,PF4,HIST2H2BE,SRC,PRDM7,CASP10,HIST1H2BL,TP53INP1,MNAT1,TSC1,RFFL,MAML3,NELFE,ZNF676,ZNF551,RAD17,SESN3,PHC1,H2AFX,CNOT11,ZNF320,TOPBP1,ZNF550,RBX1,RORA,ZNF383,AURKA,H2AFZ,RRAGC,ZNF333,ZNF302,ARID2,TFDP1,ESR1,ZNF569,CDK2,MED15,HIST1H2BC,ZNF19,RMI2,ZNF554,SMURF2,PSMD3,ZNF555,ZNF696,YAP1,E2F6,RPA1,ATF2,PPARGC1B,APAF1,RBL1,RRAGD,ZNF14,NUAK1,TAF9,SOCS4,EXO1,HEY1,RXRB,HDAC4,ZNF460,TAF11,HIST1H2BJ,YEATS4,MAPK14,SMARCA4,CCNT1,ZNF208,MBD3,PSMC4,ZNF432,PPM1A,ZNF282,ZNF234,RARG,RUNX2,ZNF596,DDIT4,ZNF267,ZFP14,ZNF619,ZNF17,POLR2F,SMAD6,RHNO1,CCNC,TAF4,ZNF3,ZNF468,ZNF287,BRD7,ZNF613,PRR5,FOS,CYCS,CDC25C,ASH2L,ZNF124,MED30,USP2,TRIM33,POLR2H,ZNF689,ZNF324B,ZNF385A,MED16,ZNF692,NFATC2,RRM2B,CDK8,ING5,ZNF79,GSK3B,TAF10,POLR2G,GP1BA,ZNF577,GTF2F2,ZNF665,BARD1,KCTD6,MYB,RABGGTB,TSC2,YES1,ZNF562,YAF2,DAXX,ACTL6B,TCEA1,TEAD4,ZNF704,CNOT1,NOTCH4,ZNF420,TXN,ZNF625,MED10,BLM,ZNF461,ZKSCAN3,ZNF607,CNOT2,MED31,PSMA7,PRKAG2,HNF4G,RRAGA,CARM1,ERCC3,SP1,ZKSCAN5,KMT2A,ZNF543,RAD51D,ZNF563,ZNF573,TBX5,KMT2E,HDAC3,SLC38A9,ELL,SMAD2,CDC7,CHD3,ZNF436,NBN,ZNF33A,ZNF586,TMEM219,LMO1,ZNF720,NDUFA4,BRD2,JAG1,GPI,WRN,RXRA,JUN,ZNF100,USP7,CNOT8,CSNK2A1,FAS,SUPT5H,NOP2,ZNF558,ZNF627,DLX5,ESRRB,ZNF615,MYL9,RBBP5,ZNF778,TAF7,MED23,POLR2K,CDK4,ZNF709,PSMB2,CCNH,GLS,MDM4,SMARCB1,RAD50,UCMA,LMO2,PRMT1,MED24,PDPK1,KMT2D,ZNF37A,ZNF225,SMARCC1,ERCC2,HIST1H2BA,CDK1,COX6B1,DPY30,ZNF667,ZNF250,ZNF514,ZNF415,ZNF701,MOV10,TPX2"]
["Glucuronidation",{"v":0.00285496764370004,"d":"2.855E-03"},{"v":0.0784812382055415,"d":"7.848E-02"},{"v":-0.582826477334444,"d":"-0.583"},{"v":-1.86886899604509,"d":"-1.869"},14,20,"UGT2B15,UGT2B11,UGT2B7,UGT2B4,UGT1A9,UGT1A3,ABHD10,SLC35D1,UGDH,UGT3A2,UGT1A4,UGT3A1,UGT2A3,UGT1A6"]
["GPCR ligand binding",{"v":0.00315687226809131,"d":"3.157E-03"},{"v":0.0849724785494577,"d":"8.497E-02"},{"v":0.24223367798231,"d":"0.242"},{"v":1.37614675406962,"d":"1.376"},12,393,"OPRD1,PTGIR,HCRT,HTR1A,LHCGR,KISS1,PTGER1,FZD9,S1PR3,F2RL3,ADM,GALR2,HTR4,DRD2,RXFP3,GPR37,ADRB2,CALCA,GPR183,INSL3,TSHR,ADRA1D,OXTR,ECE2,GNG7,GIPR,WNT2,CXCL12,CX3CL1,CCR10,FZD4,WNT9B,ADRB3,WNT6,EDN3,TAS2R9,TAAR8,CNR2,PTGFR,HRH1,RXFP1,FFAR3,WNT4,GPR4,PRLHR,ADRA2C,LPAR1,HTR1D,P2RY13,PNOC,TAS2R14,GRM6,LHB,UCN,GNG12,TAAR6,GALR1,SSTR3,GRP,XCL1,CCK,HTR5A,MTNR1B,GNG8,NTSR1,HTR6,FSHB,GCGR,FPR2,UTS2R,VIP,WNT1,RRH,OPN3,CHRM2,MC3R,CCL20,IAPP,KEL,TACR2,ADRB1,CXCL11,CNR1,CX3CR1,APLNR,CCKBR,GNG5,GABBR1,WNT7B,EDNRB,HTR1E,TACR1,S1PR5,INSL5,CCR1,CALCB,FZD10,ADRA1B,GALR3,WNT7A,NMUR1,TAC1,TRH,RXFP4,AVPR1A,HTR2B,CXCR1,MLNR,AVPR1B,PTGER3,NTS,NMU,PENK,ACKR3,PTAFR,GCG,NPY2R,PTGDR,GLP2R,TAS2R1,MCHR2,CHRM4,NPBWR1,GNB5,ADORA2B,PRLH,TAS2R41"]
["Diseases associated with O-glycosylation of proteins",{"v":0.00329308452250274,"d":"3.293E-03"},{"v":0.0868299021035417,"d":"8.683E-02"},{"v":0.439056407171729,"d":"0.439"},{"v":1.72759609366411,"d":"1.728"},14,43,"MUC17,ADAMTS6,MUC1,ADAMTS20,SEMA5A,ADAMTS18,ADAMTS19,ADAMTS16,DAG1,SBSPON,ADAMTS8,ADAMTSL3,ADAMTS15,ADAMTSL2,ADAMTS12,THBS1,MUC4,ADAMTS14,ADAMTS5,ADAMTS9,NOTCH3"]
["Voltage gated Potassium channels",{"v":0.00369324353682381,"d":"3.693E-03"},{"v":0.0954334129915273,"d":"9.543E-02"},{"v":0.447284869862424,"d":"0.447"},{"v":1.74257747628294,"d":"1.743"},16,41,"KCNAB1,KCNC3,KCNH2,KCNA5,KCNQ5,KCNA7,KCNC4,KCNS3,KCNA3,KCNAB2,KCND2,KCNQ4,KCNAB3,KCNV2,KCNQ2,KCNG3,KCNQ1,KCNF1,KCNH1"]

{"sheet":"S2F. Lof.p53 CDE genes","index":5,"n_rows":6,"n_cols":3,"rows_kept":6}
["Table S2F. Differential essentiality analysis in p53 loss of function vs wild-type cell lines and the pathway analysis for the resulting CDE+/- genes"]
["S2F. Number of differential essential genes in CRISPR-KO and shRNA KD assays, based on p53 loss-of-function (LOF) mutation vs wild-type (WT)"]
[]
[null,"CRISPR","shRNA"]
["Viability (p53 LOF-mutant>WT)",280,948]
["Viability (p53 WT>LOF-mutant)",21,988]

{"sheet":"S2G. Lof.p53 CDE and pathway","index":6,"n_rows":77,"n_cols":4,"rows_kept":77}
["S2G. CDE+/CDE- genes of p53, identified based on p53 loss-of-function mutation vs wild-type, and their significantly enriched pathways with hypergeometric test (FDR<0.1)"]
[]
["CDE+ genes (n=247)","CDE- genes (n=13)","CDE+ genes enriched pathways","CDE- genes enriched pathways"]
["AAMP; ACRBP; ADAP1; ADCY3; AHRR;","CCDC167; CCT3; CDKN1A; DEPDC1B; FAM181B; IL23R;","Complex I biogenesis","Transcriptional activation of p53 responsive genes"]
["AKR1C1; ALG2; ANKRD20A2; ANKRD49; APTX;","INHBB; KIFC1; LILRB3; ONECUT1; RSF1; TAP2; TIMELESS","Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.","Transcriptional  activation of  cell cycle inhibitor p21"]
["ARHGEF5; ATP5D; ATP5I; BAP1; BARD1;",null,"Respiratory electron transport","TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"]
["BMS1; BRAP; BRCA1; BRCA2; BRIP1;",null,"DNA Double-Strand Break Repair","TFAP2 (AP-2) family regulates transcription of cell cycle factors"]
["BRIX1; C11orf58; C19orf53; C1D; C6orf118;",null,"Homology Directed Repair","RUNX3 regulates CDKN1A transcription"]
["C9orf72; CACYBP; CASKIN1; CCNG1; CCNL1;",null,"HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)","TP53 Regulates Transcription of Cell Cycle Genes"]
["CCNT1; CCP110; CDAN1; CDH12; CDH15;",null,"The citric acid (TCA) cycle and respiratory electron transport","p53-Dependent G1 DNA Damage Response"]
["CDK4; CEBPZ; CENPF; CHCHD3; CHRAC1;",null,"DNA Repair","p53-Dependent G1/S DNA damage checkpoint"]
["CHTF18; CLPP; COQ4; COX5A; CPED1;",null,"rRNA processing in the nucleus and cytosol","G1/S DNA Damage Checkpoints"]
["CPNE7; CSH2; CTDSP2; CWF19L2; DAZAP1;",null,"HDR through Homologous Recombination (HRR)","Interleukin-4 and Interleukin-13 signaling"]
["DBNDD1; DDX31; DMBT1; DNAJA1; DROSHA;",null,"Resolution of D-loop Structures through Holliday Junction Intermediates","Regulation of gene expression in early pancreatic precursor cells"]
["E2F4; EBNA1BP2; EEF1D; EHMT1; EIF4EBP1;",null,"Resolution of D-Loop Structures","Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors"]
["ERCC4; ERCC6L2; EXO1; EXOSC1; EXOSC10;",null,"Major pathway of rRNA processing in the nucleolus and cytosol","Regulation of beta-cell development"]
["FAF1; FAM57B; FANCA; FANCC; FANCG;",null,"rRNA processing","DNA Damage/Telomere Stress Induced Senescence"]
["FDX1; FGFR1OP; FTCD; GALNTL5; GAR1;",null,"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)","Cell Cycle Checkpoints"]
["GATAD2A; GBA2; GCC1; GCSH; GDE1;",null,"Homologous DNA Pairing and Strand Exchange","Signaling by Interleukins"]
["GPATCH2; GPC6; GRIN2A; H2AFX; HEATR1;",null,"G2/M DNA damage checkpoint","Cell Cycle"]
["HERPUD2; HIST1H4K; HNRNPA2B1; HSF1; HSPA14;",null,"Processing of DNA double-strand break ends","Transcriptional regulation by RUNX3"]
["IFNA1; IFNA4; INPP5E; IRF7; KIAA1524;",null,"HDR through Single Strand Annealing (SSA)","Transcriptional regulation by RUNX2"]
["KLK4; KNTC1; KRTAP19-3; KRTAP4-2; KRTAP4-4;",null,"Presynaptic phase of homologous DNA pairing and strand exchange","Transcriptional Regulation by TP53"]
["LANCL1; LIG4; LIPT1; LPA; LYPLA1;",null,"G2/M Checkpoints","Cellular Senescence"]
["MAPRE1; MAZ; MEF2A; MGRN1; MISP;",null,"Cell Cycle Checkpoints","Cytokine Signaling in Immune system"]
["MRPS26; MXRA7; NAA30; NAF1; NANP;",null,"Nonhomologous End-Joining (NHEJ)"]
["NCL; NDUFA2; NDUFA4; NDUFA5; NDUFA8;",null,"Fanconi Anemia Pathway"]
["NDUFAF1; NDUFB10; NDUFB2; NDUFB6; NDUFB7;",null,"TRAF6 mediated IRF7 activation"]
["NDUFB8; NDUFB9; NDUFC1; NDUFS1; NDUFS2;",null,"Regulation of TP53 Activity"]
["NDUFV2; NEDD4L; NGLY1; NOC2L; NOM1;",null,"Cell Cycle"]
["NSUN3; NTAN1; OR2T33; OR2T35; ORAI3;",null,"Regulation of TP53 Activity through Phosphorylation"]
["PALB2; PAPOLA; PAQR4; PARD3; PARN;",null,"Transcriptional Regulation by TP53"]
["PARP1; PCSK4; PDSS1; PDXK; PGAP1;",null,"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"]
["PIAS4; PIGX; PIM3; PKD1; PNO1;",null,"rRNA modification in the nucleus and cytosol"]
["POLE3; POLE4; POLR1E; PON1; POP7;",null,"DNA Double Strand Break Response"]
["PPP4R2; PRRC2C; PRSS3; PSME3; PTMA;",null,"Eukaryotic Translation Elongation"]
["PWP1; QRICH1; RAB26; RAD1; RADIL;",null,"SUMOylation of DNA damage response and repair proteins"]
["RBM17; RBM34; RBM46; RDH10; RDX;",null,"Positive epigenetic regulation of rRNA expression"]
["RHBDL1; RP1L1; RPF1; RPL34; RPL36AL;",null,"RNA Polymerase I Promoter Clearance"]
["RPL6; RPS3; RPS8; SART1; SDCBP;",null,"Meiotic recombination"]
["SDHD; SFMBT2; SLC25A3; SLC27A5; SLC31A1;",null,"NoRC negatively regulates rRNA expression"]
["SLC52A2; SLX4; SPTLC1; SPTY2D1; SRCAP;",null,"B-WICH complex positively regulates rRNA expression"]
["SRD5A1; SRFBP1; SRI; STAT5A; STRA8;",null,"RNA Polymerase I Transcription"]
["SURF2; SURF6; TAF1D; TAF3; TAF8;",null,"RNA Polymerase I Chain Elongation"]
["TAS2R38; TERF1; TEX10; THUMPD1; TIMMDC1;",null,"TP53 Regulates Transcription of DNA Repair Genes"]
["TMEM8A; TNFRSF12A; TRMT1L; TTC14; TUBB2A;",null,"Global Genome Nucleotide Excision Repair (GG-NER)"]
["TUBE1; TVP23A; UBE2Q1; UBFD1; UCHL3;",null,"Meiosis"]
["ULBP2; UQCR11; URGCP; VWA8; WDR48;",null,"Negative epigenetic regulation of rRNA expression"]
["WDR74; WDR75; WRN; XRCC1; XRCC4;",null,"Metabolism of RNA"]
["YWHAE; YY1; ZC3H3; ZDHHC2; ZDHHC7;",null,"Recruitment of NuMA to mitotic centrosomes"]
["ZFR; ZNF124; ZNF253; ZNF574; ZNF622;",null,"DDX58/IFIH1-mediated induction of interferon-alpha/beta"]
["ZNF668; ZNF688; ZNF705A; ZNF771; ZNHIT3;",null,"Peptide chain elongation"]
["ZNHIT6; ZWILCH",null,"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"]
[null,null,"Eukaryotic Translation Initiation"]
[null,null,"Cap-dependent Translation Initiation"]
[null,null,"Formation of a pool of free 40S subunits"]
[null,null,"Telomere Maintenance"]
[null,null,"Eukaryotic Translation Termination"]
[null,null,"Mitotic Prometaphase"]
[null,null,"Epigenetic regulation of gene expression"]
[null,null,"G2/M Transition"]
[null,null,"Mitotic G2-G2/M phases"]
[null,null,"Viral mRNA Translation"]
[null,null,"Signaling by TGF-beta Receptor Complex"]
[null,null,"Selenocysteine synthesis"]
[null,null,"L13a-mediated translational silencing of Ceruloplasmin expression"]
[null,null,"Nucleotide Excision Repair"]
[null,null,"Cell Cycle, Mitotic"]
[null,null,"SRP-dependent cotranslational protein targeting to membrane"]
[null,null,"GTP hydrolysis and joining of the 60S ribosomal subunit"]
[null,null,"Reproduction"]
[null,null,"Nonsense-Mediated Decay (NMD)"]
[null,null,"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"]
[null,null,"UCH proteinases"]
[null,null,"Resolution of Sister Chromatid Cohesion"]
[null,null,"Cilium Assembly"]
[null,null,"Gene expression (Transcription)"]