{"text_format":"3","workbook":"xls","n_sheets":1,"sheets":["Supporting file 6_Table S5"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Supporting file 6_Table S5","index":0,"n_rows":139,"n_cols":8,"rows_kept":139,"flags":["formulas_cached_only"]}
["Table S5. KEGG signals enriched. "]
["ID","Description","p value","p.adjust","q value","gene ID","Count","Enrich_factor"]
["hsa05161","Hepatitis B",{"v":1.2e-21,"d":"1.20E-21"},{"v":2.06e-19,"d":"2.06E-19"},{"v":4.29e-20,"d":"4.29E-20"},"MAPK14/MAPK8/TP53/MAP2K1/MAP2K3/SMAD4/MAP2K6/MAPK1/TYK2/STAT3/JAK2/CREB1/STAT6/STAT5A/TBK1/NFKBIA/AKT1",17,{"v":27.4,"d":"27.40"}]
["hsa05235","PD-L1 expression and PD-1 checkpoint pathway in cancer",{"v":2.46e-18,"d":"2.46E-18"},{"v":2.12e-16,"d":"2.12E-16"},{"v":4.4e-17,"d":"4.40E-17"},"PTPN6/MAPK14/MAP2K1/MAP2K3/PTPN11/MAP2K6/MAPK1/STAT3/JAK2/ZAP70/NFKBIA/AKT1/EGFR",13,{"v":38.1,"d":"38.10"}]
["hsa04659","Th17 cell differentiation",{"v":1.75e-15,"d":"1.75E-15"},{"v":1.01e-13,"d":"1.01E-13"},{"v":2.09e-14,"d":"2.09E-14"},"MAPK14/MAPK8/SMAD4/MAPK1/TYK2/STAT3/JAK2/ZAP70/STAT6/STAT5A/NFKBIA/SMAD2",12,{"v":29.3,"d":"29.30"}]
["hsa05167","Kaposi sarcoma-associated herpesvirus infection",{"v":7.7e-14,"d":"7.70E-14"},{"v":3.31e-12,"d":"3.31E-12"},{"v":6.89e-13,"d":"6.89E-13"},"MAPK14/MAPK8/TP53/MAP2K1/MAP2K6/MAPK1/TYK2/STAT3/JAK2/CREB1/TBK1/NFKBIA/AKT1",13,{"v":17.6,"d":"17.60"}]
["hsa04935","Growth hormone synthesis, secretion and action",{"v":2.9e-13,"d":"2.90E-13"},{"v":9.97e-12,"d":"9.97E-12"},{"v":2.07e-12,"d":"2.07E-12"},"MAPK14/MAPK8/MAP2K1/MAP2K3/MAP2K6/MAPK1/STAT3/JAK2/CREB1/STAT5A/AKT1",11,{"v":24.1,"d":"24.10"}]
["hsa05135","Yersinia infection",{"v":1.4e-12,"d":"1.40E-12"},{"v":4e-11,"d":"4.00E-11"},{"v":8.33e-12,"d":"8.33E-12"},"MAPK14/MAPK8/MAP2K1/RPS6KA1/MAP2K3/MAP2K6/MAPK1/ZAP70/TBK1/NFKBIA/AKT1",11,{"v":20.9,"d":"20.90"}]
["hsa05212","Pancreatic cancer",{"v":6e-12,"d":"6.00E-12"},{"v":1.15e-10,"d":"1.15E-10"},{"v":2.39e-11,"d":"2.39E-11"},"MAPK8/TP53/MAP2K1/SMAD4/MAPK1/STAT3/SMAD2/AKT1/EGFR",9,{"v":30.9,"d":"30.90"}]
["hsa04668","TNF signaling pathway",{"v":6.01e-12,"d":"6.01E-12"},{"v":1.15e-10,"d":"1.15E-10"},{"v":2.39e-11,"d":"2.39E-11"},"MAPK14/MAPK8/MAP2K1/MAP2K3/RPS6KA4/MAP2K6/MAPK1/CREB1/NFKBIA/AKT1",10,{"v":23.3,"d":"23.30"}]
["hsa05145","Toxoplasmosis",{"v":6.01e-12,"d":"6.01E-12"},{"v":1.15e-10,"d":"1.15E-10"},{"v":2.39e-11,"d":"2.39E-11"},"MAPK14/MAPK8/MAP2K3/MAP2K6/MAPK1/TYK2/STAT3/JAK2/NFKBIA/AKT1",10,{"v":23.3,"d":"23.30"}]
["hsa05163","Human cytomegalovirus infection",{"v":1.42e-11,"d":"1.42E-11"},{"v":2.45e-10,"d":"2.45E-10"},{"v":5.09e-11,"d":"5.09E-11"},"MAPK14/TP53/MAP2K1/MAP2K6/MAPK1/STAT3/CREB1/TBK1/NFKBIA/EIF4EBP1/AKT1/EGFR",12,{"v":13.9,"d":"13.90"}]
["hsa04068","FoxO signaling pathway",{"v":2.93e-11,"d":"2.93E-11"},{"v":4.57e-10,"d":"4.57E-10"},{"v":9.52e-11,"d":"9.52E-11"},"MAPK14/MAPK8/MAP2K1/SMAD4/MAPK1/STAT3/ATM/PRKAA1/AKT1/EGFR",10,{"v":19.9,"d":"19.90"}]
["hsa04658","Th1 and Th2 cell differentiation",{"v":3.52e-11,"d":"3.52E-11"},{"v":5.04e-10,"d":"5.04E-10"},{"v":1.05e-10,"d":"1.05E-10"},"MAPK14/MAPK8/MAPK1/TYK2/JAK2/ZAP70/STAT6/STAT5A/NFKBIA",9,{"v":25.5,"d":"25.50"}]
["hsa04933","AGE-RAGE signaling pathway in diabetic complications",{"v":7.55e-11,"d":"7.55E-11"},{"v":9.99e-10,"d":"9.99E-10"},{"v":2.08e-10,"d":"2.08E-10"},"MAPK14/MAPK8/SMAD4/MAPK1/STAT3/JAK2/STAT5A/SMAD2/AKT1",9,{"v":23.5,"d":"23.50"}]
["hsa04620","Toll-like receptor signaling pathway",{"v":1.08e-10,"d":"1.08E-10"},{"v":1.33e-09,"d":"1.33E-09"},{"v":2.76e-10,"d":"2.76E-10"},"MAPK14/MAPK8/MAP2K1/MAP2K3/MAP2K6/MAPK1/TBK1/NFKBIA/AKT1",9,{"v":22.6,"d":"22.60"}]
["hsa04917","Prolactin signaling pathway",{"v":1.41e-10,"d":"1.41E-10"},{"v":1.61e-09,"d":"1.61E-09"},{"v":3.36e-10,"d":"3.36E-10"},"MAPK14/MAPK8/MAP2K1/MAPK1/STAT3/JAK2/STAT5A/AKT1",8,{"v":29.8,"d":"29.80"}]
["hsa04218","Cellular senescence",{"v":1.67e-10,"d":"1.67E-10"},{"v":1.8e-09,"d":"1.80E-09"},{"v":3.74e-10,"d":"3.74E-10"},"MAPK14/TP53/MAP2K1/MAP2K3/MAP2K6/MAPK1/ATM/EIF4EBP1/SMAD2/AKT1",10,{"v":16.7,"d":"16.70"}]
["hsa05160","Hepatitis C",{"v":1.78e-10,"d":"1.78E-10"},{"v":1.8e-09,"d":"1.80E-09"},{"v":3.75e-10,"d":"3.75E-10"},"TP53/MAP2K1/MAPK1/TYK2/EIF2S1/STAT3/TBK1/NFKBIA/AKT1/EGFR",10,{"v":16.6,"d":"16.60"}]
["hsa05166","Human T-cell leukemia virus 1 infection",{"v":2.35e-10,"d":"2.35E-10"},{"v":2.25e-09,"d":"2.25E-09"},{"v":4.68e-10,"d":"4.68E-10"},"MAPK8/TP53/MAP2K1/SMAD4/MAPK1/ATM/CREB1/STAT5A/NFKBIA/SMAD2/AKT1",11,{"v":13.1,"d":"13.10"}]
["hsa05220","Chronic myeloid leukemia",{"v":2.77e-10,"d":"2.77E-10"},{"v":2.51e-09,"d":"2.51E-09"},{"v":5.21e-10,"d":"5.21E-10"},"TP53/MAP2K1/SMAD4/PTPN11/MAPK1/STAT5A/NFKBIA/AKT1",8,{"v":27.5,"d":"27.50"}]
["hsa04010","MAPK signaling pathway",{"v":3.24e-10,"d":"3.24E-10"},{"v":2.79e-09,"d":"2.79E-09"},{"v":5.8e-10,"d":"5.80E-10"},"MAPK14/MAPK8/TP53/MAP2K1/RPS6KA1/HSPB1/MAP2K3/RPS6KA4/MAP2K6/MAPK1/AKT1/EGFR",12,{"v":10.6,"d":"10.60"}]
["hsa04722","Neurotrophin signaling pathway",{"v":3.66e-10,"d":"3.66E-10"},{"v":3e-09,"d":"3.00E-09"},{"v":6.24e-10,"d":"6.24E-10"},"MAPK14/MAPK8/TP53/MAP2K1/RPS6KA1/PTPN11/MAPK1/NFKBIA/AKT1",9,{"v":19.7,"d":"19.70"}]
["hsa04380","Osteoclast differentiation",{"v":7.06e-10,"d":"7.06E-10"},{"v":5.44e-09,"d":"5.44E-09"},{"v":1.13e-09,"d":"1.13E-09"},"MAPK14/MAPK8/MAP2K1/MAP2K6/MAPK1/TYK2/CREB1/NFKBIA/AKT1",9,{"v":18.3,"d":"18.30"}]
["hsa04926","Relaxin signaling pathway",{"v":7.57e-10,"d":"7.57E-10"},{"v":5.44e-09,"d":"5.44E-09"},{"v":1.13e-09,"d":"1.13E-09"},"MAPK14/MAPK8/MAP2K1/MAPK1/CREB1/NFKBIA/SMAD2/AKT1/EGFR",9,{"v":18.2,"d":"18.20"}]
["hsa05210","Colorectal cancer",{"v":7.59e-10,"d":"7.59E-10"},{"v":5.44e-09,"d":"5.44E-09"},{"v":1.13e-09,"d":"1.13E-09"},"MAPK8/TP53/MAP2K1/SMAD4/MAPK1/SMAD2/AKT1/EGFR",8,{"v":24.3,"d":"24.30"}]
["hsa05162","Measles",{"v":1.48e-09,"d":"1.48E-09"},{"v":1.02e-08,"d":"1.02E-08"},{"v":2.11e-09,"d":"2.11E-09"},"MAPK8/TP53/TYK2/EIF2S1/STAT3/STAT5A/TBK1/NFKBIA/AKT1",9,{"v":16.9,"d":"16.90"}]
["hsa04550","Signaling pathways regulating pluripotency of stem cells",{"v":1.9e-09,"d":"1.90E-09"},{"v":1.26e-08,"d":"1.26E-08"},{"v":2.62e-09,"d":"2.62E-09"},"MAPK14/MAP2K1/SMAD4/SMAD5/MAPK1/STAT3/JAK2/SMAD2/AKT1",9,{"v":16.4,"d":"16.40"}]
["hsa05169","Epstein-Barr virus infection",{"v":2.13e-09,"d":"2.13E-09"},{"v":1.35e-08,"d":"1.35E-08"},{"v":2.82e-09,"d":"2.82E-09"},"MAPK14/MAPK8/TP53/MAP2K3/MAP2K6/TYK2/STAT3/TBK1/NFKBIA/AKT1",10,{"v":12.9,"d":"12.90"}]
["hsa05205","Proteoglycans in cancer",{"v":2.45e-09,"d":"2.45E-09"},{"v":1.51e-08,"d":"1.51E-08"},{"v":3.14e-09,"d":"3.14E-09"},"PTPN6/MAPK14/TP53/MAP2K1/PTPN11/MAPK1/STAT3/SMAD2/AKT1/EGFR",10,{"v":12.7,"d":"12.70"}]
["hsa05170","Human immunodeficiency virus 1 infection",{"v":3.4e-09,"d":"3.40E-09"},{"v":2.02e-08,"d":"2.02E-08"},{"v":4.2e-09,"d":"4.20E-09"},"MAPK14/MAPK8/MAP2K1/MAP2K3/MAP2K6/MAPK1/ATM/TBK1/NFKBIA/AKT1",10,{"v":12.3,"d":"12.30"}]
["hsa04660","T cell receptor signaling pathway",{"v":3.52e-09,"d":"3.52E-09"},{"v":2.02e-08,"d":"2.02E-08"},{"v":4.2e-09,"d":"4.20E-09"},"PTPN6/MAPK14/MAPK8/MAP2K1/MAPK1/ZAP70/NFKBIA/AKT1",8,{"v":20.1,"d":"20.10"}]
["hsa04931","Insulin resistance",{"v":4.76e-09,"d":"4.76E-09"},{"v":2.61e-08,"d":"2.61E-08"},{"v":5.43e-09,"d":"5.43E-09"},"MAPK8/RPS6KA1/PTPN11/STAT3/CREB1/NFKBIA/PRKAA1/AKT1",8,{"v":19.3,"d":"19.30"}]
["hsa04664","Fc epsilon RI signaling pathway",{"v":4.86e-09,"d":"4.86E-09"},{"v":2.61e-08,"d":"2.61E-08"},{"v":5.43e-09,"d":"5.43E-09"},"MAPK14/MAPK8/MAP2K1/MAP2K3/MAP2K6/MAPK1/AKT1",7,{"v":26.9,"d":"26.90"}]
["hsa04920","Adipocytokine signaling pathway",{"v":5.39e-09,"d":"5.39E-09"},{"v":2.81e-08,"d":"2.81E-08"},{"v":5.85e-09,"d":"5.85E-09"},"MAPK8/PTPN11/STAT3/JAK2/NFKBIA/PRKAA1/AKT1",7,{"v":26.5,"d":"26.50"}]
["hsa04630","JAK-STAT signaling pathway",{"v":5.75e-09,"d":"5.75E-09"},{"v":2.91e-08,"d":"2.91E-08"},{"v":6.05e-09,"d":"6.05E-09"},"PTPN6/PTPN11/TYK2/STAT3/JAK2/STAT6/STAT5A/AKT1/EGFR",9,{"v":14.5,"d":"14.50"}]
["hsa05223","Non-small cell lung cancer",{"v":7.3e-09,"d":"7.30E-09"},{"v":3.59e-08,"d":"3.59E-08"},{"v":7.47e-09,"d":"7.47E-09"},"TP53/MAP2K1/MAPK1/STAT3/STAT5A/AKT1/EGFR",7,{"v":25.4,"d":"25.40"}]
["hsa01521","EGFR tyrosine kinase inhibitor resistance",{"v":1.41e-08,"d":"1.41E-08"},{"v":6.74e-08,"d":"6.74E-08"},{"v":1.4e-08,"d":"1.40E-08"},"MAP2K1/MAPK1/STAT3/JAK2/EIF4EBP1/AKT1/EGFR",7,{"v":23.1,"d":"23.10"}]
["hsa04012","ErbB signaling pathway",{"v":2.37e-08,"d":"2.37E-08"},{"v":1.1e-07,"d":"1.10E-07"},{"v":2.29e-08,"d":"2.29E-08"},"MAPK8/MAP2K1/MAPK1/STAT5A/EIF4EBP1/AKT1/EGFR",7,{"v":21.5,"d":"21.50"}]
["hsa04210","Apoptosis",{"v":2.96e-08,"d":"2.96E-08"},{"v":1.34e-07,"d":"1.34E-07"},{"v":2.79e-08,"d":"2.79E-08"},"MAPK8/TP53/MAP2K1/MAPK1/EIF2S1/ATM/NFKBIA/AKT1",8,{"v":15.3,"d":"15.30"}]
["hsa04912","GnRH signaling pathway",{"v":4.45e-08,"d":"4.45E-08"},{"v":1.96e-07,"d":"1.96E-07"},{"v":4.08e-08,"d":"4.08E-08"},"MAPK14/MAPK8/MAP2K1/MAP2K3/MAP2K6/MAPK1/EGFR",7,{"v":19.6,"d":"19.60"}]
["hsa05215","Prostate cancer",{"v":5.97e-08,"d":"5.97E-08"},{"v":2.57e-07,"d":"2.57E-07"},{"v":5.34e-08,"d":"5.34E-08"},"TP53/MAP2K1/MAPK1/CREB1/NFKBIA/AKT1/EGFR",7,{"v":18.8,"d":"18.80"}]
["hsa01522","Endocrine resistance",{"v":6.41e-08,"d":"6.41E-08"},{"v":2.69e-07,"d":"2.69E-07"},{"v":5.59e-08,"d":"5.59E-08"},"MAPK14/MAPK8/TP53/MAP2K1/MAPK1/AKT1/EGFR",7,{"v":18.6,"d":"18.60"}]
["hsa05221","Acute myeloid leukemia",{"v":1.61e-07,"d":"1.61E-07"},{"v":6.6e-07,"d":"6.60E-07"},{"v":1.37e-07,"d":"1.37E-07"},"MAP2K1/MAPK1/STAT3/STAT5A/EIF4EBP1/AKT1",6,{"v":23.4,"d":"23.40"}]
["hsa05164","Influenza A",{"v":1.77e-07,"d":"1.77E-07"},{"v":7.07e-07,"d":"7.07E-07"},{"v":1.47e-07,"d":"1.47E-07"},"MAP2K1/MAPK1/TYK2/EIF2S1/JAK2/TBK1/NFKBIA/AKT1",8,{"v":12.2,"d":"12.20"}]
["hsa05131","Shigellosis",{"v":2.16e-07,"d":"2.16E-07"},{"v":8.46e-07,"d":"8.46E-07"},{"v":1.76e-07,"d":"1.76E-07"},"MAPK14/MAPK8/TP53/MAPK1/ATM/TBK1/NFKBIA/AKT1/EGFR",9,9.54]
["hsa05165","Human papillomavirus infection",{"v":2.37e-07,"d":"2.37E-07"},{"v":9.07e-07,"d":"9.07E-07"},{"v":1.89e-07,"d":"1.89E-07"},"TP53/MAP2K1/MAPK1/TYK2/ATM/CREB1/TBK1/EIF4EBP1/AKT1/EGFR",10,7.88]
["hsa04140","Autophagy - animal",{"v":6.43e-07,"d":"6.43E-07"},{"v":2.4e-06,"d":"2.40E-06"},{"v":5e-07,"d":"5.00E-07"},"MAPK8/MAP2K1/MAPK1/EIF2S1/TBK1/PRKAA1/AKT1",7,{"v":13.3,"d":"13.30"}]
["hsa05226","Gastric cancer",{"v":1.14e-06,"d":"1.14E-06"},{"v":4.16e-06,"d":"4.16E-06"},{"v":8.65e-07,"d":"8.65E-07"},"TP53/MAP2K1/SMAD4/MAPK1/SMAD2/AKT1/EGFR",7,{"v":12.3,"d":"12.30"}]
["hsa05231","Choline metabolism in cancer",{"v":1.56e-06,"d":"1.56E-06"},{"v":5.61e-06,"d":"5.61E-06"},{"v":1.17e-06,"d":"1.17E-06"},"MAPK8/MAP2K1/MAPK1/EIF4EBP1/AKT1/EGFR",6,{"v":16,"d":"16.00"}]
["hsa04914","Progesterone-mediated oocyte maturation",{"v":1.76e-06,"d":"1.76E-06"},{"v":6.12e-06,"d":"6.12E-06"},{"v":1.27e-06,"d":"1.27E-06"},"MAPK14/MAPK8/MAP2K1/RPS6KA1/MAPK1/AKT1",6,{"v":15.7,"d":"15.70"}]
["hsa04014","Ras signaling pathway",{"v":1.81e-06,"d":"1.81E-06"},{"v":6.12e-06,"d":"6.12E-06"},{"v":1.27e-06,"d":"1.27E-06"},"MAPK8/MAP2K1/PTPN11/MAPK1/ZAP70/TBK1/AKT1/EGFR",8,{"v":9,"d":"9.00"}]
["hsa05171","Coronavirus disease - COVID-19",{"v":1.81e-06,"d":"1.81E-06"},{"v":6.12e-06,"d":"6.12E-06"},{"v":1.27e-06,"d":"1.27E-06"},"MAPK14/MAPK8/MAPK1/TYK2/STAT3/TBK1/NFKBIA/EGFR",8,{"v":9,"d":"9.00"}]
["hsa05142","Chagas disease",{"v":1.98e-06,"d":"1.98E-06"},{"v":6.55e-06,"d":"6.55E-06"},{"v":1.36e-06,"d":"1.36E-06"},"MAPK14/MAPK8/MAPK1/NFKBIA/SMAD2/AKT1",6,{"v":15.3,"d":"15.30"}]
["hsa04625","C-type lectin receptor signaling pathway",{"v":2.22e-06,"d":"2.22E-06"},{"v":7.2e-06,"d":"7.20E-06"},{"v":1.5e-06,"d":"1.50E-06"},"MAPK14/MAPK8/PTPN11/MAPK1/NFKBIA/AKT1",6,{"v":15.1,"d":"15.10"}]
["hsa05213","Endometrial cancer",{"v":2.35e-06,"d":"2.35E-06"},{"v":7.47e-06,"d":"7.47E-06"},{"v":1.55e-06,"d":"1.55E-06"},"TP53/MAP2K1/MAPK1/AKT1/EGFR",5,{"v":22.5,"d":"22.50"}]
["hsa05225","Hepatocellular carcinoma",{"v":2.55e-06,"d":"2.55E-06"},{"v":7.85e-06,"d":"7.85E-06"},{"v":1.63e-06,"d":"1.63E-06"},"TP53/MAP2K1/SMAD4/MAPK1/SMAD2/AKT1/EGFR",7,{"v":10.9,"d":"10.90"}]
["hsa04370","VEGF signaling pathway",{"v":2.56e-06,"d":"2.56E-06"},{"v":7.85e-06,"d":"7.85E-06"},{"v":1.63e-06,"d":"1.63E-06"},"MAPK14/MAP2K1/HSPB1/MAPK1/AKT1",5,{"v":22.1,"d":"22.10"}]
["hsa04066","HIF-1 signaling pathway",{"v":2.92e-06,"d":"2.92E-06"},{"v":8.82e-06,"d":"8.82E-06"},{"v":1.84e-06,"d":"1.84E-06"},"MAP2K1/MAPK1/STAT3/EIF4EBP1/AKT1/EGFR",6,{"v":14.4,"d":"14.40"}]
["hsa05132","Salmonella infection",{"v":3.08e-06,"d":"3.08E-06"},{"v":9.14e-06,"d":"9.14E-06"},{"v":1.9e-06,"d":"1.90E-06"},"MAPK14/MAPK8/MAP2K1/MAP2K3/MAP2K6/MAPK1/NFKBIA/AKT1",8,8.38]
["hsa04151","PI3K-Akt signaling pathway",{"v":4.57e-06,"d":"4.57E-06"},{"v":1.33e-05,"d":"1.33E-05"},{"v":2.77e-06,"d":"2.77E-06"},"TP53/MAP2K1/MAPK1/JAK2/CREB1/EIF4EBP1/PRKAA1/AKT1/EGFR",9,6.63]
["hsa04071","Sphingolipid signaling pathway",{"v":4.88e-06,"d":"4.88E-06"},{"v":1.4e-05,"d":"1.40E-05"},{"v":2.91e-06,"d":"2.91E-06"},"MAPK14/MAPK8/TP53/MAP2K1/MAPK1/AKT1",6,{"v":13.2,"d":"13.20"}]
["hsa05120","Epithelial cell signaling in Helicobacter pylori infection",{"v":6e-06,"d":"6.00E-06"},{"v":1.66e-05,"d":"1.66E-05"},{"v":3.46e-06,"d":"3.46E-06"},"MAPK14/MAPK8/PTPN11/NFKBIA/EGFR",5,{"v":18.6,"d":"18.60"}]
["hsa05230","Central carbon metabolism in cancer",{"v":6e-06,"d":"6.00E-06"},{"v":1.66e-05,"d":"1.66E-05"},{"v":3.46e-06,"d":"3.46E-06"},"TP53/MAP2K1/MAPK1/AKT1/EGFR",5,{"v":18.6,"d":"18.60"}]
["hsa05218","Melanoma",{"v":6.9e-06,"d":"6.90E-06"},{"v":1.88e-05,"d":"1.88E-05"},{"v":3.92e-06,"d":"3.92E-06"},"TP53/MAP2K1/MAPK1/AKT1/EGFR",5,{"v":18.1,"d":"18.10"}]
["hsa05214","Glioma",{"v":8.44e-06,"d":"8.44E-06"},{"v":2.27e-05,"d":"2.27E-05"},{"v":4.72e-06,"d":"4.72E-06"},"TP53/MAP2K1/MAPK1/AKT1/EGFR",5,{"v":17.4,"d":"17.40"}]
["hsa05140","Leishmaniasis",{"v":9.61e-06,"d":"9.61E-06"},{"v":2.54e-05,"d":"2.54E-05"},{"v":5.29e-06,"d":"5.29E-06"},"PTPN6/MAPK14/MAPK1/JAK2/NFKBIA",5,{"v":16.9,"d":"16.90"}]
["hsa04371","Apelin signaling pathway",{"v":1.1e-05,"d":"1.10E-05"},{"v":2.82e-05,"d":"2.82E-05"},{"v":5.87e-06,"d":"5.87E-06"},"MAP2K1/SMAD4/MAPK1/PRKAA1/SMAD2/AKT1",6,{"v":11.4,"d":"11.40"}]
["hsa04910","Insulin signaling pathway",{"v":1.1e-05,"d":"1.10E-05"},{"v":2.82e-05,"d":"2.82E-05"},{"v":5.87e-06,"d":"5.87E-06"},"MAPK8/MAP2K1/MAPK1/EIF4EBP1/PRKAA1/AKT1",6,{"v":11.4,"d":"11.40"}]
["hsa04015","Rap1 signaling pathway",{"v":1.11e-05,"d":"1.11E-05"},{"v":2.82e-05,"d":"2.82E-05"},{"v":5.87e-06,"d":"5.87E-06"},"MAPK14/MAP2K1/MAP2K3/MAP2K6/MAPK1/AKT1/EGFR",7,{"v":8.7,"d":"8.70"}]
["hsa05418","Fluid shear stress and atherosclerosis",{"v":1.2e-05,"d":"1.20E-05"},{"v":2.98e-05,"d":"2.98E-05"},{"v":6.2e-06,"d":"6.20E-06"},"MAPK14/MAPK8/TP53/MAP2K6/PRKAA1/AKT1",6,{"v":11.3,"d":"11.30"}]
["hsa04662","B cell receptor signaling pathway",{"v":1.31e-05,"d":"1.31E-05"},{"v":3.22e-05,"d":"3.22E-05"},{"v":6.69e-06,"d":"6.69E-06"},"PTPN6/MAP2K1/MAPK1/NFKBIA/AKT1",5,{"v":15.9,"d":"15.90"}]
["hsa05219","Bladder cancer",{"v":1.62e-05,"d":"1.62E-05"},{"v":3.93e-05,"d":"3.93E-05"},{"v":8.17e-06,"d":"8.17E-06"},"TP53/MAP2K1/MAPK1/EGFR",4,{"v":25.5,"d":"25.50"}]
["hsa04211","Longevity regulating pathway",{"v":1.95e-05,"d":"1.95E-05"},{"v":4.67e-05,"d":"4.67E-05"},{"v":9.72e-06,"d":"9.72E-06"},"TP53/CREB1/EIF4EBP1/PRKAA1/AKT1",5,{"v":14.7,"d":"14.70"}]
["hsa04150","mTOR signaling pathway",{"v":2.23e-05,"d":"2.23E-05"},{"v":5.25e-05,"d":"5.25E-05"},{"v":1.09e-05,"d":"1.09E-05"},"MAP2K1/RPS6KA1/MAPK1/EIF4EBP1/PRKAA1/AKT1",6,{"v":10.1,"d":"10.10"}]
["hsa04657","IL-17 signaling pathway",{"v":2.55e-05,"d":"2.55E-05"},{"v":5.91e-05,"d":"5.91E-05"},{"v":1.23e-05,"d":"1.23E-05"},"MAPK14/MAPK8/MAPK1/TBK1/NFKBIA",5,{"v":13.9,"d":"13.90"}]
["hsa04217","Necroptosis",{"v":2.58e-05,"d":"2.58E-05"},{"v":5.91e-05,"d":"5.91E-05"},{"v":1.23e-05,"d":"1.23E-05"},"MAPK8/TYK2/STAT3/JAK2/STAT6/STAT5A",6,9.84]
["hsa05022","Pathways of neurodegeneration - multiple diseases",{"v":4.86e-05,"d":"4.86E-05"},{"v":0.00011,"d":"1.10E-04"},{"v":2.29e-05,"d":"2.29E-05"},"MAPK14/MAPK8/MAP2K1/MAP2K3/MAP2K6/MAPK1/EIF2S1/TBK1/PSMD9",9,4.94]
["hsa05152","Tuberculosis",{"v":5.18e-05,"d":"5.18E-05"},{"v":0.000116,"d":"1.16E-04"},{"v":2.41e-05,"d":"2.41E-05"},"MAPK14/MAPK8/MAPK1/JAK2/CREB1/AKT1",6,{"v":8.7,"d":"8.70"}]
["hsa04621","NOD-like receptor signaling pathway",{"v":5.35e-05,"d":"5.35E-05"},{"v":0.000118,"d":"1.18E-04"},{"v":2.45e-05,"d":"2.45E-05"},"MAPK14/MAPK8/MAPK1/TYK2/TBK1/NFKBIA",6,8.65]
["hsa04725","Cholinergic synapse",{"v":6.2e-05,"d":"6.20E-05"},{"v":0.000135,"d":"1.35E-04"},{"v":2.81e-05,"d":"2.81E-05"},"MAP2K1/MAPK1/JAK2/CREB1/AKT1",5,{"v":11.5,"d":"11.50"}]
["hsa05168","Herpes simplex virus 1 infection",{"v":7.04e-05,"d":"7.04E-05"},{"v":0.000151,"d":"1.51E-04"},{"v":3.15e-05,"d":"3.15E-05"},"TP53/PTPN11/TYK2/EIF2S1/JAK2/TBK1/NFKBIA/EIF4EBP1/AKT1",9,4.71]
["hsa04062","Chemokine signaling pathway",{"v":7.43e-05,"d":"7.43E-05"},{"v":0.000158,"d":"1.58E-04"},{"v":3.28e-05,"d":"3.28E-05"},"MAP2K1/MAPK1/STAT3/JAK2/NFKBIA/AKT1",6,8.15]
["hsa05130","Pathogenic Escherichia coli infection",{"v":8.57e-05,"d":"8.57E-05"},{"v":0.00018,"d":"1.80E-04"},{"v":3.74e-05,"d":"3.74E-05"},"PTPN6/MAPK14/MAPK8/PTPN11/MAPK1/NFKBIA",6,7.95]
["hsa05203","Viral carcinogenesis",{"v":0.000104,"d":"1.04E-04"},{"v":0.000216,"d":"2.16E-04"},{"v":4.49e-05,"d":"4.49E-05"},"TP53/MAPK1/STAT3/CREB1/STAT5A/NFKBIA",6,7.67]
["hsa04650","Natural killer cell mediated cytotoxicity",{"v":0.000125,"d":"1.25E-04"},{"v":0.000256,"d":"2.56E-04"},{"v":5.33e-05,"d":"5.33E-05"},"PTPN6/MAP2K1/PTPN11/MAPK1/ZAP70",5,9.96]
["hsa05211","Renal cell carcinoma",{"v":0.000128,"d":"1.28E-04"},{"v":0.00026,"d":"2.60E-04"},{"v":5.41e-05,"d":"5.41E-05"},"MAP2K1/PTPN11/MAPK1/AKT1",4,{"v":15.1,"d":"15.10"}]
["hsa04622","RIG-I-like receptor signaling pathway",{"v":0.000136,"d":"1.36E-04"},{"v":0.000272,"d":"2.72E-04"},{"v":5.65e-05,"d":"5.65E-05"},"MAPK14/MAPK8/TBK1/NFKBIA",4,{"v":14.9,"d":"14.90"}]
["hsa04024","cAMP signaling pathway",{"v":0.000143,"d":"1.43E-04"},{"v":0.00028,"d":"2.80E-04"},{"v":5.84e-05,"d":"5.84E-05"},"MAPK8/MAP2K1/MAPK1/CREB1/NFKBIA/AKT1",6,7.25]
["hsa04520","Adherens junction",{"v":0.000144,"d":"1.44E-04"},{"v":0.00028,"d":"2.80E-04"},{"v":5.84e-05,"d":"5.84E-05"},"PTPN6/SMAD4/MAPK1/EGFR",4,{"v":14.7,"d":"14.70"}]
["hsa01524","Platinum drug resistance",{"v":0.00016,"d":"1.60E-04"},{"v":0.000306,"d":"3.06E-04"},{"v":6.36e-05,"d":"6.36E-05"},"TP53/MAPK1/ATM/AKT1",4,{"v":14.3,"d":"14.30"}]
["hsa04915","Estrogen signaling pathway",{"v":0.00016,"d":"1.60E-04"},{"v":0.000306,"d":"3.06E-04"},{"v":6.36e-05,"d":"6.36E-05"},"MAP2K1/MAPK1/CREB1/AKT1/EGFR",5,9.45]
["hsa05224","Breast cancer",{"v":0.000215,"d":"2.15E-04"},{"v":0.000407,"d":"4.07E-04"},{"v":8.46e-05,"d":"8.46E-05"},"TP53/MAP2K1/MAPK1/AKT1/EGFR",5,8.87]
["hsa04072","Phospholipase D signaling pathway",{"v":0.000222,"d":"2.22E-04"},{"v":0.000415,"d":"4.15E-04"},{"v":8.64e-05,"d":"8.64E-05"},"MAP2K1/PTPN11/MAPK1/AKT1/EGFR",5,8.81]
["hsa05216","Thyroid cancer",{"v":0.000363,"d":"3.63E-04"},{"v":0.000666,"d":"6.66E-04"},{"v":0.000138,"d":"1.38E-04"},"TP53/MAP2K1/MAPK1",3,{"v":21.2,"d":"21.20"}]
["hsa05014","Amyotrophic lateral sclerosis",{"v":0.000364,"d":"3.64E-04"},{"v":0.000666,"d":"6.66E-04"},{"v":0.000138,"d":"1.38E-04"},"MAPK14/TP53/MAP2K3/MAP2K6/EIF2S1/TBK1/PSMD9",7,5.02]
["hsa04350","TGF-beta signaling pathway",{"v":0.000424,"d":"4.24E-04"},{"v":0.000767,"d":"7.67E-04"},{"v":0.00016,"d":"1.60E-04"},"SMAD4/SMAD5/MAPK1/SMAD2",4,{"v":11.1,"d":"11.10"}]
["hsa04750","Inflammatory mediator regulation of TRP channels",{"v":0.000496,"d":"4.96E-04"},{"v":0.000889,"d":"8.89E-04"},{"v":0.000185,"d":"1.85E-04"},"MAPK14/MAPK8/MAP2K3/MAP2K6",4,{"v":10.6,"d":"10.60"}]
["hsa05020","Prion disease",{"v":0.000506,"d":"5.06E-04"},{"v":0.000897,"d":"8.97E-04"},{"v":0.000187,"d":"1.87E-04"},"MAPK14/MAPK8/MAPK1/EIF2S1/CREB1/PSMD9",6,5.73]
["hsa04928","Parathyroid hormone synthesis, secretion and action",{"v":0.000668,"d":"6.68E-04"},{"v":0.00117,"d":"1.17E-03"},{"v":0.000244,"d":"2.44E-04"},"MAP2K1/MAPK1/CREB1/EGFR",4,9.84]
["hsa04510","Focal adhesion",{"v":0.000906,"d":"9.06E-04"},{"v":0.00157,"d":"1.57E-03"},{"v":0.000327,"d":"3.27E-04"},"MAPK8/MAP2K1/MAPK1/AKT1/EGFR",5,6.49]
["hsa05206","MicroRNAs in cancer",{"v":0.000989,"d":"9.89E-04"},{"v":0.0017,"d":"1.70E-03"},{"v":0.000354,"d":"3.54E-04"},"TP53/MAP2K1/MAPK1/STAT3/ATM/EGFR",6,5.05]
["hsa04152","AMPK signaling pathway",{"v":0.00106,"d":"1.06E-03"},{"v":0.00181,"d":"1.81E-03"},{"v":0.000377,"d":"3.77E-04"},"CREB1/EIF4EBP1/PRKAA1/AKT1",4,{"v":8.7,"d":"8.70"}]
["hsa04919","Thyroid hormone signaling pathway",{"v":0.0011,"d":"1.10E-03"},{"v":0.00185,"d":"1.85E-03"},{"v":0.000385,"d":"3.85E-04"},"TP53/MAP2K1/MAPK1/AKT1",4,8.62]
["hsa04110","Cell cycle",{"v":0.0012,"d":"1.20E-03"},{"v":0.00201,"d":"2.01E-03"},{"v":0.000418,"d":"4.18E-04"},"TP53/SMAD4/ATM/SMAD2",4,8.42]
["hsa04114","Oocyte meiosis",{"v":0.00139,"d":"1.39E-03"},{"v":0.0023,"d":"2.30E-03"},{"v":0.000479,"d":"4.79E-04"},"MAPK14/MAP2K1/RPS6KA1/MAPK1",4,8.09]
["hsa04728","Dopaminergic synapse",{"v":0.00152,"d":"1.52E-03"},{"v":0.00248,"d":"2.48E-03"},{"v":0.000517,"d":"5.17E-04"},"MAPK14/MAPK8/CREB1/AKT1",4,7.91]
["hsa04714","Thermogenesis",{"v":0.00169,"d":"1.69E-03"},{"v":0.00274,"d":"2.74E-03"},{"v":0.000569,"d":"5.69E-04"},"MAPK14/RPS6KA1/MAP2K3/CREB1/PRKAA1",5,5.65]
["hsa04929","GnRH secretion",{"v":0.00181,"d":"1.81E-03"},{"v":0.00292,"d":"2.92E-03"},{"v":0.000607,"d":"6.07E-04"},"MAP2K1/MAPK1/AKT1",3,{"v":12.2,"d":"12.20"}]
["hsa05321","Inflammatory bowel disease",{"v":0.0019,"d":"1.90E-03"},{"v":0.00302,"d":"3.02E-03"},{"v":0.000629,"d":"6.29E-04"},"STAT3/STAT6/SMAD2",3,{"v":12,"d":"12.00"}]
["hsa04720","Long-term potentiation",{"v":0.00207,"d":"2.07E-03"},{"v":0.00327,"d":"3.27E-03"},{"v":0.00068,"d":"6.80E-04"},"MAP2K1/RPS6KA1/MAPK1",3,{"v":11.7,"d":"11.70"}]
["hsa04137","Mitophagy - animal",{"v":0.00216,"d":"2.16E-03"},{"v":0.00338,"d":"3.38E-03"},{"v":0.000703,"d":"7.03E-04"},"MAPK8/TP53/TBK1",3,{"v":11.5,"d":"11.50"}]
["hsa05010","Alzheimer disease",{"v":0.00242,"d":"2.42E-03"},{"v":0.00369,"d":"3.69E-03"},{"v":0.000767,"d":"7.67E-04"},"MAPK8/MAP2K1/MAPK1/EIF2S1/AKT1/PSMD9",6,4.24]
["hsa04261","Adrenergic signaling in cardiomyocytes",{"v":0.00242,"d":"2.42E-03"},{"v":0.00369,"d":"3.69E-03"},{"v":0.000767,"d":"7.67E-04"},"MAPK14/MAPK1/CREB1/AKT1",4,6.96]
["hsa04932","Non-alcoholic fatty liver disease",{"v":0.00242,"d":"2.42E-03"},{"v":0.00369,"d":"3.69E-03"},{"v":0.000767,"d":"7.67E-04"},"MAPK8/EIF2S1/PRKAA1/AKT1",4,6.96]
["hsa04921","Oxytocin signaling pathway",{"v":0.00267,"d":"2.67E-03"},{"v":0.00402,"d":"4.02E-03"},{"v":0.000837,"d":"8.37E-04"},"MAP2K1/MAPK1/PRKAA1/EGFR",4,6.78]
["hsa04934","Cushing syndrome",{"v":0.00273,"d":"2.73E-03"},{"v":0.00408,"d":"4.08E-03"},{"v":0.000849,"d":"8.49E-04"},"MAP2K1/MAPK1/CREB1/EGFR",4,6.73]
["hsa05133","Pertussis",{"v":0.00297,"d":"2.97E-03"},{"v":0.0044,"d":"4.40E-03"},{"v":0.000916,"d":"9.16E-04"},"MAPK14/MAPK8/MAPK1",3,{"v":10.3,"d":"10.30"}]
["hsa04022","cGMP-PKG signaling pathway",{"v":0.00357,"d":"3.57E-03"},{"v":0.00525,"d":"5.25E-03"},{"v":0.00109,"d":"1.09E-03"},"MAP2K1/MAPK1/CREB1/AKT1",4,6.25]
["hsa04540","Gap junction",{"v":0.00449,"d":"4.49E-03"},{"v":0.00655,"d":"6.55E-03"},{"v":0.00136,"d":"1.36E-03"},"MAP2K1/MAPK1/EGFR",3,8.89]
["hsa05222","Small cell lung cancer",{"v":0.00509,"d":"5.09E-03"},{"v":0.00735,"d":"7.35E-03"},{"v":0.00153,"d":"1.53E-03"},"TP53/NFKBIA/AKT1",3,8.51]
["hsa04613","Neutrophil extracellular trap formation",{"v":0.00565,"d":"5.65E-03"},{"v":0.0081,"d":"8.10E-03"},{"v":0.00169,"d":"1.69E-03"},"MAPK14/MAP2K1/MAPK1/AKT1",4,5.49]
["hsa04666","Fc gamma R-mediated phagocytosis",{"v":0.0059,"d":"5.90E-03"},{"v":0.00838,"d":"8.38E-03"},{"v":0.00174,"d":"1.74E-03"},"MAP2K1/MAPK1/AKT1",3,8.07]
["hsa04710","Circadian rhythm",{"v":0.00617,"d":"6.17E-03"},{"v":0.0087,"d":"8.70E-03"},{"v":0.00181,"d":"1.81E-03"},"CREB1/PRKAA1",2,{"v":16.8,"d":"16.80"}]
["hsa04916","Melanogenesis",{"v":0.00659,"d":"6.59E-03"},{"v":0.00922,"d":"9.22E-03"},{"v":0.00192,"d":"1.92E-03"},"MAP2K1/MAPK1/CREB1",3,7.75]
["hsa04064","NF-kappa B signaling pathway",{"v":0.00715,"d":"7.15E-03"},{"v":0.00992,"d":"9.92E-03"},{"v":0.00206,"d":"2.06E-03"},"ATM/ZAP70/NFKBIA",3,7.53]
["hsa04922","Glucagon signaling pathway",{"v":0.00773,"d":"7.73E-03"},{"v":0.0106,"d":"1.06E-02"},{"v":0.00221,"d":"2.21E-03"},"CREB1/PRKAA1/AKT1",3,7.31]
["hsa04611","Platelet activation",{"v":0.0116,"d":"1.16E-02"},{"v":0.0158,"d":"1.58E-02"},{"v":0.00329,"d":"3.29E-03"},"MAPK14/MAPK1/AKT1",3,6.31]
["hsa04930","Type II diabetes mellitus",{"v":0.0133,"d":"1.33E-02"},{"v":0.018,"d":"1.80E-02"},{"v":0.00374,"d":"3.74E-03"},"MAPK8/MAPK1",2,{"v":11.3,"d":"11.30"}]
["hsa05012","Parkinson disease",{"v":0.0144,"d":"1.44E-02"},{"v":0.0193,"d":"1.93E-02"},{"v":0.00402,"d":"4.02E-03"},"MAPK8/TP53/EIF2S1/PSMD9",4,4.19]
["hsa05017","Spinocerebellar ataxia",{"v":0.0169,"d":"1.69E-02"},{"v":0.0226,"d":"2.26E-02"},{"v":0.0047,"d":"4.70E-03"},"MAPK8/AKT1/PSMD9",3,5.47]
["hsa04723","Retrograde endocannabinoid signaling",{"v":0.0186,"d":"1.86E-02"},{"v":0.0246,"d":"2.46E-02"},{"v":0.00511,"d":"5.11E-03"},"MAPK14/MAPK8/MAPK1",3,5.29]
["hsa04730","Long-term depression",{"v":0.0219,"d":"2.19E-02"},{"v":0.0288,"d":"2.88E-02"},{"v":0.00599,"d":"5.99E-03"},"MAP2K1/MAPK1",2,{"v":8.7,"d":"8.70"}]
["hsa04310","Wnt signaling pathway",{"v":0.0228,"d":"2.28E-02"},{"v":0.0297,"d":"2.97E-02"},{"v":0.00618,"d":"6.18E-03"},"MAPK8/TP53/SMAD4",3,4.89]
["hsa04213","Longevity regulating pathway - multiple species",{"v":0.0233,"d":"2.33E-02"},{"v":0.0302,"d":"3.02E-02"},{"v":0.00627,"d":"6.27E-03"},"PRKAA1/AKT1",2,8.42]
["hsa04623","Cytosolic DNA-sensing pathway",{"v":0.024,"d":"2.40E-02"},{"v":0.0308,"d":"3.08E-02"},{"v":0.00642,"d":"6.42E-03"},"TBK1/NFKBIA",2,8.28]
["hsa05016","Huntington disease",{"v":0.0283,"d":"2.83E-02"},{"v":0.036,"d":"3.60E-02"},{"v":0.0075,"d":"7.50E-03"},"MAPK8/TP53/CREB1/PSMD9",4,3.41]
["hsa04115","p53 signaling pathway",{"v":0.0316,"d":"3.16E-02"},{"v":0.0399,"d":"3.99E-02"},{"v":0.00831,"d":"8.31E-03"},"TP53/ATM",2,7.15]
["hsa05034","Alcoholism",{"v":0.034,"d":"3.40E-02"},{"v":0.0427,"d":"4.27E-02"},{"v":0.00889,"d":"8.89E-03"},"MAP2K1/MAPK1/CREB1",3,4.19]