ONTOLOGY	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
BP	GO:0009991	response to extracellular stimulus	60/365	477/18862	1.50599157760861e-31	7.88235991720347e-28	3.02942095243164e-28	XBP1/SPP1/CBS/CYBB/GABARAP/PTPRC/CD4/BCL2/MAP1LC3A/DNMT3A/EIF2AK2/MTOR/ATF4/HNRNPA1/WDR45/MFSD2A/HSD11B2/SORL1/ICAM1/MAPK1/BCHE/GATA4/PPARA/MAPK3/PPARG/SRC/LAMP2/DDIT3/EGFR/UCP2/ATF3/SLC2A1/FOS/VCAM1/CCND1/MTHFR/ADRB2/LEP/FAS/LRRK2/APOE/CDKN1A/JUN/BGLAP/GHRL/PRL/ACSL4/LPL/SOD2/ADIPOQ/CNR1/POMC/CYP1A1/HTR2C/NTRK1/GDF15/SLC6A4/NQO1/NPY/MPO	60
BP	GO:0031667	response to nutrient levels	57/365	451/18862	4.42304459518855e-30	1.15751077056084e-26	4.44865169547648e-27	XBP1/SPP1/CYBB/GABARAP/CD4/BCL2/MAP1LC3A/DNMT3A/EIF2AK2/MTOR/ATF4/HNRNPA1/WDR45/MFSD2A/HSD11B2/SORL1/ICAM1/MAPK1/BCHE/GATA4/PPARA/MAPK3/PPARG/SRC/LAMP2/DDIT3/EGFR/UCP2/ATF3/SLC2A1/VCAM1/CCND1/MTHFR/ADRB2/LEP/FAS/LRRK2/APOE/CDKN1A/JUN/BGLAP/GHRL/PRL/ACSL4/LPL/SOD2/ADIPOQ/CNR1/POMC/CYP1A1/HTR2C/NTRK1/GDF15/SLC6A4/NQO1/NPY/MPO	57
BP	GO:0070997	neuron death	50/365	342/18862	2.01217177682252e-29	3.5105690266297e-26	1.34921412824837e-26	CCL5/STXBP1/BCL2/IKBKG/HRAS/MEF2C/NUPR1/PARP1/PINK1/CTNNB1/CEBPB/ATP13A2/CLN3/NF1/DNAJC5/MTOR/MECP2/XIAP/HSP90AB1/ATF4/GSK3B/HDAC4/SORL1/SNCA/ATM/PPARA/NGF/BCL2L11/DDIT3/FOS/FAS/LRRK2/APOE/FASLG/JUN/NGFR/CCL2/CSF3/BAX/APP/TERT/IFNG/CLU/GDNF/SOD2/NTRK1/GRIN2B/EGR1/IL10/NQO1	50
BP	GO:0070482	response to oxygen levels	52/365	385/18862	7.12122582691466e-29	9.31812399451783e-26	3.58122698821945e-26	CYBB/EDN1/RPS27A/BCL2/DNMT3A/PINK1/STUB1/EP300/ATP7A/NF1/MTOR/MECP2/ATF4/CREBBP/RORA/HSD11B2/ICAM1/ATM/PPARA/PPARG/ETS1/SRC/UCP2/AGER/SLC2A1/VCAM1/MTHFR/LEP/FAS/CXCR4/CDKN1A/NOTCH1/CXCL12/ITPR1/TLR2/TERT/MMP2/PDGFRB/MYC/RYR2/SLC2A4/SOD2/ADIPOQ/CYP1A1/VEGFA/NOX4/NOS2/EGR1/CAV1/NOS1/BMP2/SLC6A4	52
BP	GO:0050673	epithelial cell proliferation	54/365	428/18862	1.81349898621488e-28	1.89837073876974e-25	7.29599276348766e-26	XBP1/EDNRB/AKT3/HRAS/MEF2C/NUPR1/PURA/ATP7A/CEBPB/PRKDC/NF1/MTOR/SP1/RTN4/GJA1/MAPK1/PPARG/AGTR1/SOX2/EGFR/HMGB1/CCND1/LEP/APOE/PRKCA/B2M/KDR/IL6/BRCA2/NOTCH1/AR/CXCL12/FGFR2/STAT1/DLX5/BMP4/NGFR/CCL2/THBS4/KIT/GHRL/BAX/PRL/IGF1/MYC/TNFSF11/VEGFA/NR4A1/CAV1/SCN5A/XDH/BMP2/SHH/IL10	54
BP	GO:1901214	regulation of neuron death	46/365	302/18862	6.69502238446946e-28	5.84029119338552e-25	2.24459434679318e-25	CCL5/STXBP1/BCL2/IKBKG/HRAS/MEF2C/NUPR1/PARP1/PINK1/CTNNB1/CEBPB/ATP13A2/CLN3/NF1/DNAJC5/MTOR/MECP2/HSP90AB1/ATF4/GSK3B/HDAC4/SORL1/SNCA/ATM/PPARA/NGF/BCL2L11/DDIT3/FOS/LRRK2/APOE/FASLG/JUN/CCL2/CSF3/BAX/TERT/IFNG/CLU/GDNF/SOD2/NTRK1/GRIN2B/EGR1/IL10/NQO1	46
BP	GO:0072593	reactive oxygen species metabolic process	44/365	281/18862	3.14788908678083e-27	2.35372164003013e-24	9.04603916517018e-25	HBA1/KLF4/CYBB/ABCD1/EDN1/BCL2/NDUFS4/PINK1/ATP7A/MTOR/HSP90AA1/HSP90AB1/RORA/HDAC4/ICAM1/GADD45A/SNCA/PPARA/AGTR1/BRCA1/EGFR/LEP/LRRK2/PRDX1/CDKN1A/HBB/GRIN1/MMP3/TLR2/IFNG/PDGFRB/AGT/CLU/SOD2/CYP1A1/NOX4/NOS2/CAV1/XDH/NOS1/HP/IL10/NQO1/MPO	44
BP	GO:0036293	response to decreased oxygen levels	48/365	360/18862	1.97713596487054e-26	1.29354120501655e-23	4.97145635377315e-24	CYBB/EDN1/RPS27A/BCL2/DNMT3A/PINK1/STUB1/EP300/ATP7A/NF1/MTOR/MECP2/ATF4/CREBBP/RORA/HSD11B2/ICAM1/ATM/PPARA/ETS1/SRC/UCP2/AGER/SLC2A1/VCAM1/MTHFR/LEP/CXCR4/NOTCH1/CXCL12/ITPR1/TLR2/TERT/MMP2/MYC/RYR2/SLC2A4/SOD2/ADIPOQ/CYP1A1/VEGFA/NOX4/NOS2/EGR1/CAV1/NOS1/BMP2/SLC6A4	48
BP	GO:0062197	cellular response to chemical stress	47/365	347/18862	3.40135744566321e-26	1.97807831895569e-23	7.60233225574549e-24	MMP9/KLF4/CYBB/ABCD1/BCL2/MAP1LC3A/ARNTL/PARP1/PINK1/ATP7A/TXN/ATP13A2/CLN3/MTR/ATF4/SETX/HSPB1/NFE2L1/MAPK1/SNCA/GATA4/ATM/MAPK3/PPARG/ETS1/SRC/DDIT3/EGFR/SLC2A1/FOS/FAS/LRRK2/PRDX1/IL6/JUN/HSPA1B/MMP3/HSPA1A/MMP2/SLC2A4/SOD2/NOX4/CAV1/TRPV4/IL10/NQO1/MPO	47
BP	GO:0001666	response to hypoxia	47/365	348/18862	3.86652056917287e-26	2.02373686590508e-23	7.7778113765151e-24	CYBB/EDN1/RPS27A/BCL2/DNMT3A/PINK1/STUB1/EP300/ATP7A/NF1/MTOR/MECP2/CREBBP/RORA/HSD11B2/ICAM1/ATM/PPARA/ETS1/SRC/UCP2/AGER/SLC2A1/VCAM1/MTHFR/LEP/CXCR4/NOTCH1/CXCL12/ITPR1/TLR2/TERT/MMP2/MYC/RYR2/SLC2A4/SOD2/ADIPOQ/CYP1A1/VEGFA/NOX4/NOS2/EGR1/CAV1/NOS1/BMP2/SLC6A4	47
BP	GO:0006979	response to oxidative stress	52/365	444/18862	7.25536674417725e-26	3.45223541263852e-23	1.32679481800218e-23	HBA1/MMP9/KLF4/CYBB/ABCD1/EDN1/PTGS1/BCL2/MAP1LC3A/ARNTL/PARP1/PINK1/ATP7A/TXN/ATP13A2/MTR/ATF4/SP1/SETX/HSPB1/NFE2L1/MAPK1/SNCA/GATA4/CYP2E1/MAPK3/ETS1/SRC/EGFR/UCP2/FOS/LRRK2/APOE/PRDX1/IL6/HBB/JUN/HSPA1B/MMP3/TXNIP/HSPA1A/APP/MMP2/PDGFRB/SOD2/ADIPOQ/NOX4/HP/IL10/NQO1/MBL2/MPO	52
BP	GO:0050678	regulation of epithelial cell proliferation	48/365	374/18862	1.10794747686775e-25	4.83249757827151e-23	1.85726984938094e-23	XBP1/EDNRB/AKT3/HRAS/MEF2C/NUPR1/ATP7A/PRKDC/NF1/MTOR/SP1/RTN4/GJA1/PPARG/AGTR1/SOX2/EGFR/HMGB1/CCND1/LEP/APOE/PRKCA/B2M/KDR/BRCA2/NOTCH1/AR/CXCL12/FGFR2/STAT1/DLX5/BMP4/NGFR/CCL2/THBS4/GHRL/BAX/PRL/IGF1/MYC/VEGFA/NR4A1/CAV1/SCN5A/XDH/BMP2/SHH/IL10	48
BP	GO:0007568	aging	42/365	304/18862	8.023309109683e-24	3.23030768308314e-21	1.24150151486674e-21	EDNRB/GNRH1/EDN1/MIF/BCL2/DNMT3A/AKT3/HRAS/DAG1/ARNTL/PRKDC/MTOR/ICAM1/MAPK1/ATM/MAPK3/UCP2/AGER/FOS/VCAM1/LEP/LRRK2/B2M/CDKN1A/BRCA2/JUN/BGLAP/APP/TERT/SERPINE1/PDGFRB/SOD2/CNR1/CYP1A1/NTRK1/NOX4/MME/FOXG1/CDKN2A/IL10/NQO1/MPO	42
BP	GO:0050727	regulation of inflammatory response	45/365	366/18862	2.47592915756146e-23	9.25643800762622e-21	3.55751926323305e-21	MMP9/EDNRB/KLF4/CCL5/PTPRC/NFKBIA/NUPR1/CLOCK/CEBPB/XIAP/BRD4/RORA/TNFRSF1A/SNCA/IL18/ATM/PPARA/CASP4/PPARG/ETS1/AGTR1/PIK3CG/IL1R1/EGFR/AGER/LRRK2/APOE/IL6/MMP3/TLR2/GHRL/APP/HLA-DRB1/NLRP3/IFNG/IGF1/SERPINE1/LPL/AGT/TNFSF11/ADIPOQ/CNR1/C3/IL10/PROC	45
BP	GO:0042493	response to drug	44/365	359/18862	8.97073169183469e-23	3.13018731167085e-20	1.20302233425236e-20	CYBB/EDN1/BCL2/DNMT3A/MEF2C/ATP1A1/CTNNB1/HSP90AB1/CYP2D6/HDAC4/HSD11B2/ICAM1/CYP2U1/BCHE/GATA4/CYP2E1/PPARG/SRC/EGFR/FOS/CCND1/MTHFR/CXCR4/B2M/CDKN1A/JUN/BGLAP/TXNIP/KCNQ1/MYC/LPL/SOD2/ADIPOQ/CYP1A1/ADAM10/HTR2C/NTRK1/NOS2/KCNH2/NOS1/GRIN2A/IL10/SLC6A4/NQO1	44
BP	GO:0060284	regulation of cell development	50/365	485/18862	2.21142974747984e-22	7.23413956144342e-20	2.78029095225919e-20	LRP2/SPP1/L1CAM/EDNRB/BCL2/DAG1/ARNTL/CTNNB1/CLOCK/PRKDC/GLI3/NF1/MTOR/GSK3B/CUX1/RTN4/TNFRSF1A/HDAC4/SORL1/NGF/PPARG/CHD7/DICER1/CDKL5/CXCR4/LRRK2/B2M/IL6/NOTCH1/CXCL12/BMP4/NGFR/KIT/TLR2/IL1RAPL1/IFNG/IGF1/TNFSF11/AURKA/ADIPOQ/VEGFA/GJC2/FBN1/MME/FN1/FOXG1/RELN/BMP2/SHH/PROC	50
BP	GO:0097305	response to alcohol	36/365	233/18862	3.18619490067581e-22	9.80973182949246e-20	3.77016622612475e-20	CCR5/KLF4/CYBB/GNRH1/DNMT3A/DAG1/PARP1/CTNNB1/ICAM1/PPARA/CD14/CYP2E1/PPARG/BRCA1/CFTR/FOS/VCAM1/CCND1/GRAMD1B/LEP/AHR/CDKN1A/FGFR2/BGLAP/GRIN1/CSF3/DRD4/NLRP3/SLC2A4/SOD2/ADIPOQ/CNR1/GRIN2B/GRIN2A/NQO1/DBH	36
BP	GO:1903793	positive regulation of anion transport	49/365	478/18862	7.73907494257664e-22	2.25035101385812e-19	8.64875568144091e-20	SPP1/PIK3R2/OCLN/EDN1/STXBP1/BCL2/NFKBIA/HRAS/PINK1/CEBPB/GLI3/ATP13A2/CLN3/HSP90AB1/ATF4/GSK3B/TARDBP/HUWE1/SORL1/GJA1/MAPK1/SRC/CETP/CFTR/EGFR/PLA2G6/LEP/APOE/ABCA1/CXCL12/FASLG/ANK3/TLR2/GHRL/TERT/ACSL4/DRD4/HLA-DRB1/IFNG/IGF1/CYP19A1/TNFSF11/GDNF/PLA2G4A/ADIPOQ/CAV1/C3/SHH/SLC6A4	49
BP	GO:0051402	neuron apoptotic process	35/365	230/18862	2.07963248170418e-21	5.72884021538932e-19	2.20176048339983e-19	STXBP1/BCL2/HRAS/MEF2C/NUPR1/PARP1/PINK1/CTNNB1/CEBPB/CLN3/NF1/DNAJC5/MECP2/XIAP/HSP90AB1/ATF4/HDAC4/ATM/NGF/BCL2L11/DDIT3/FAS/APOE/FASLG/JUN/NGFR/CCL2/BAX/APP/TERT/GDNF/SOD2/NTRK1/IL10/NQO1	35
BP	GO:0048638	regulation of developmental growth	40/365	319/18862	3.8333084279407e-21	9.63335730862972e-19	3.70238035050005e-19	SPP1/L1CAM/EDN1/BCL2/MEF2C/NEDD4L/RAI1/PRKDC/MTOR/GSK3B/RTN4/MFSD2A/GJA1/MAPK1/PPARA/NGF/CHD7/BCL2L11/CDKL5/ADRB2/LEP/CXCR4/APOE/CDKN1A/NOTCH1/PPIB/AR/CXCL12/FGFR2/BMP4/GHRL/APP/PRL/IGF1/VEGFA/GHR/GDF15/FN1/SLC6A4/ERBB4	40
BP	GO:0023061	signal release	48/365	475/18862	3.86512234392862e-21	9.63335730862972e-19	3.70238035050005e-19	SPP1/CCL5/EDN1/STXBP1/MEF2C/ARNTL/PINK1/CLOCK/DNAJC5/GSK3B/TARDBP/GJA1/SNCA/CHD7/AGTR1/CFTR/EGFR/UCP2/SLC2A1/PLA2G6/LEP/LRRK2/PRKCA/IL1RN/IL6/ABCA1/CXCL12/ITPR1/GHRL/ACSL4/HLA-DRB1/IFNG/AGT/CYP19A1/TNFSF11/GDNF/PLA2G4A/ADIPOQ/CNR1/KCNA2/POMC/HTR2C/CRHR1/CAMK2A/NOS2/P2RY12/NRXN1/SLC6A4	48
BP	GO:0043491	protein kinase B signaling	37/365	273/18862	8.52060067821519e-21	1.88880434519882e-18	7.25922632116915e-19	LRP2/KLF4/PIK3R2/CCL5/IGF1R/DAG1/PINK1/TXN/MTOR/HSP90AA1/HSP90AB1/SETX/RTN4/IL18/GATA4/PPARA/SRC/PIK3CG/DDIT3/EGFR/LEP/NRG1/KDR/KITLG/FGFR2/CCL2/KIT/CSF3/IGF1/PDGFRB/TNFSF11/NTRK1/GDF15/CALCR/XDH/P2RY12/ERBB4	37
BP	GO:0032496	response to lipopolysaccharide	40/365	326/18862	8.57547393952746e-21	1.88880434519882e-18	7.25922632116915e-19	XBP1/CCR5/EDNRB/CCL5/GNRH1/EDN1/NFKBIA/MEF2C/RPS6KA3/CEBPB/GJA1/ICAM1/MAPK1/SNCA/IL18/CD14/MAPK3/SRC/HMGB1/FOS/VCAM1/PRKCA/IL6/NOTCH1/FASLG/JUN/FGFR2/CCL2/TLR2/CSF3/NLRP3/SERPINE1/SOD2/CNR1/CYP1A1/NOS2/IL24/NOS1/IL10/MPO	40
BP	GO:0000302	response to reactive oxygen species	34/365	224/18862	8.66092936277638e-21	1.88880434519882e-18	7.25922632116915e-19	HBA1/MMP9/KLF4/EDN1/BCL2/MAP1LC3A/PINK1/ATP7A/TXN/MTR/SETX/MAPK1/CYP2E1/MAPK3/ETS1/SRC/EGFR/UCP2/FOS/LRRK2/APOE/PRDX1/IL6/HBB/JUN/MMP3/TXNIP/MMP2/PDGFRB/SOD2/HP/IL10/NQO1/MPO	34
BP	GO:0002237	response to molecule of bacterial origin	41/365	346/18862	1.01494601269815e-20	2.12489097218484e-18	8.16657612743647e-19	XBP1/CCR5/EDNRB/CCL5/GNRH1/EDN1/NFKBIA/MEF2C/RPS6KA3/CEBPB/GJA1/ICAM1/MAPK1/SNCA/IL18/CD14/MAPK3/SRC/HMGB1/FOS/VCAM1/PRKCA/B2M/IL6/NOTCH1/FASLG/JUN/FGFR2/CCL2/TLR2/CSF3/NLRP3/SERPINE1/SOD2/CNR1/CYP1A1/NOS2/IL24/NOS1/IL10/MPO	41
BP	GO:0042391	regulation of membrane potential	45/365	431/18862	1.9923200711413e-20	4.01069355859753e-18	1.54142658135669e-18	NPPA/ABCD1/EDN1/BCL2/MEF2C/NEDD4L/ATP1A1/PARP1/PINK1/CLN3/MECP2/GSK3B/P2RX7/GJA1/ANK2/SRC/CFTR/UCP2/ADRB2/DMPK/LRRK2/KDR/NLGN3/JUN/GRIN1/ANK3/KCNQ1/GHRL/BAX/APP/DRD4/RYR2/CASQ2/SOD2/CNR1/KCNA2/GABRG2/GRIN2B/GRIA1/CAV1/KCNH2/SCN5A/GRIN2A/NRXN1/RELN	45
BP	GO:0034599	cellular response to oxidative stress	38/365	299/18862	2.45209467586368e-20	4.75343093832242e-18	1.82688223219318e-18	MMP9/KLF4/CYBB/ABCD1/BCL2/MAP1LC3A/ARNTL/PARP1/PINK1/ATP7A/TXN/ATP13A2/MTR/ATF4/SETX/HSPB1/NFE2L1/MAPK1/SNCA/GATA4/MAPK3/ETS1/SRC/EGFR/FOS/LRRK2/PRDX1/IL6/JUN/HSPA1B/MMP3/HSPA1A/MMP2/SOD2/NOX4/IL10/NQO1/MPO	38
BP	GO:0043434	response to peptide hormone	45/365	435/18862	2.88480956021275e-20	5.39253329934056e-18	2.07250792088969e-18	XBP1/EDNRB/PIK3R2/CYBB/GNRH1/SORT1/EDN1/IGF1R/DAG1/PARP1/PRKDC/MTOR/GSK3B/SP1/ARID1B/HSD11B2/SORL1/GJA1/ICAM1/PPARA/PPARG/AGTR1/SRC/UCP2/SLC2A1/LEP/CXCL12/STAT1/BGLAP/TLR2/GHRL/PRL/LPL/SLC2A4/SOCS1/ADIPOQ/GHR/CRHR1/NR4A1/GDF15/CAMK2A/FBN1/EGR1/CAV1/IL10	45
BP	GO:0051091	positive regulation of DNA-binding transcription factor activity	36/365	266/18862	3.07365933491379e-20	5.54742515825474e-18	2.13203738258448e-18	EDN1/RPS27A/IKBKG/EIF2AK2/PINK1/CTNNB1/EP300/CLOCK/TRAPPC9/HDAC4/ICAM1/IL18/PPARG/DDIT3/AGER/IL6/AR/HSPA1B/KIT/HSPA1A/TLR2/CSF3/APP/NLRP3/AGT/CLU/TNFSF11/VEGFA/NTRK1/CAMK2A/CAV1/ESR2/RELN/CD40LG/SHH/IL10	36
BP	GO:0051098	regulation of binding	41/365	357/18862	3.28167780910053e-20	5.61307189897942e-18	2.15726734085829e-18	MMP9/KLF4/NFKBIA/PARP1/CTNNB1/STUB1/NSD1/EP300/TXN/HSP90AB1/GSK3B/CYP2D6/HDAC4/SORL1/PPARA/NGF/MAPK3/PPARG/SRC/DDIT3/HMGB1/AGER/ADRB2/LRRK2/APOE/B2M/CDKN1A/JUN/BMP4/CSF3/BAX/APP/TERT/IFNG/IGF1/TNFSF11/AURKA/ADIPOQ/CAV1/BMP2/IL10	41
BP	GO:0009612	response to mechanical stimulus	32/365	202/18862	3.32451717364085e-20	5.61307189897942e-18	2.15726734085829e-18	NPPA/EDN1/NFKBIA/DAG1/ATP1A1/CTNNB1/HTT/TNFRSF1A/HDAC4/GJA1/GADD45A/GATA4/MAPK3/PPARG/ETS1/SRC/EGFR/SLC2A1/FOS/FAS/CXCR4/CXCL12/JUN/BGLAP/KIT/TXNIP/RYR2/CDH2/NTRK1/TRPV4/NRXN1/MPO	32
BP	GO:0001819	positive regulation of cytokine production	45/365	437/18862	3.46579239484051e-20	5.66873668581101e-18	2.17866094294086e-18	XBP1/PTPRC/MIF/CD4/EIF2AK2/HRAS/CTNNB1/EP300/CEBPB/PRKDC/HSP90AA1/ATF4/CREBBP/RORA/P2RX7/SORL1/HSPB1/IL18/GATA4/CD14/IL1R1/BRCA1/DDIT3/HMGB1/AGER/LEP/FURIN/B2M/IL6/STAT1/HSPA1B/HSPA1A/TLR2/APP/NLRP3/IFNG/SERPINE1/LPL/AGT/CLU/ADIPOQ/EGR1/C3/CD40LG/IL10	45
BP	GO:0007611	learning or memory	34/365	235/18862	4.15958589273451e-20	6.59735532199165e-18	2.53555618533195e-18	MEF2C/EP300/HTT/CEBPB/CLN3/NF1/MTOR/MECP2/MAPK1/BCHE/NGF/EGFR/AGER/FOS/APOE/B2M/NLGN3/JUN/GRIN1/KIT/TLR2/APP/SLC2A4/CNR1/NTRK1/GRIN2B/MME/AFF2/GRIA1/SLC6A1/GRIN2A/NRXN1/SLC6A4/DBH	34
BP	GO:0048660	regulation of smooth muscle cell proliferation	29/365	160/18862	4.3135813119407e-20	6.64037781961694e-18	2.55209098672405e-18	MMP9/KLF4/CCL5/EDN1/MEF2C/CTNNB1/PRKDC/MTOR/HDAC4/GJA1/IL18/PPARG/DNMT1/EGFR/CDKN1A/IL6/ELN/JUN/FGFR2/STAT1/BMP4/TERT/MMP2/IFNG/IGF1/PDGFRB/SOD2/ADIPOQ/IL10	29
BP	GO:0048659	smooth muscle cell proliferation	29/365	162/18862	6.18845009376162e-20	8.84398455784376e-18	3.39900136557316e-18	MMP9/KLF4/CCL5/EDN1/MEF2C/CTNNB1/PRKDC/MTOR/HDAC4/GJA1/IL18/PPARG/DNMT1/EGFR/CDKN1A/IL6/ELN/JUN/FGFR2/STAT1/BMP4/TERT/MMP2/IFNG/IGF1/PDGFRB/SOD2/ADIPOQ/IL10	29
BP	GO:0043405	regulation of MAP kinase activity	38/365	307/18862	6.22858397294412e-20	8.84398455784376e-18	3.39900136557316e-18	NPPA/PTPRC/EDN1/RPS27A/IGF1R/IKBKG/HRAS/NF1/SORL1/MAPK1/GADD45A/MAPK3/SRC/PIK3CG/EGFR/AGER/TF/CXCR4/LRRK2/APOE/NRG1/KITLG/BMP4/KIT/GHRL/DRD4/IGF1/PDGFRB/AGT/TNFSF11/ADIPOQ/VEGFA/GHR/GDF15/CAV1/CD40LG/UCHL1/BMP2	38
BP	GO:0030001	metal ion transport	47/365	486/18862	6.3609414310871e-20	8.84398455784376e-18	3.39900136557316e-18	LRP2/CCR5/NPPA/PLP1/CCL5/TRPM1/PTPRC/CD4/BCL2/ATP1A1/PSEN2/CTNNB1/HTT/ATP7A/P2RX7/GJA1/ICAM1/SNCA/ANK2/CHD7/PIK3CG/SPG7/DDIT3/CXCR4/CXCL12/FASLG/GRIN1/CCL2/ITPR1/KCNQ1/BAX/DRD4/PDGFRB/RYR2/CASQ2/HTR2C/CRHR1/GRIN2B/CAMK2A/GJC2/CAV1/KCNH2/TRPV4/CALCR/P2RY12/NOS1/GRIN2A	47
BP	GO:0033002	muscle cell proliferation	33/365	222/18862	6.42092879629467e-20	8.84398455784376e-18	3.39900136557316e-18	MMP9/KLF4/CCL5/EDN1/MEF2C/CTNNB1/PRKDC/MTOR/HDAC4/GJA1/MAPK1/IL18/PPARG/DNMT1/EGFR/CDKN1A/IL6/NOTCH1/ELN/JUN/FGFR2/STAT1/BMP4/TERT/MMP2/IFNG/IGF1/PDGFRB/SOD2/ADIPOQ/SHH/IL10/ERBB4	33
BP	GO:2000377	regulation of reactive oxygen species metabolic process	31/365	192/18862	7.39596239524416e-20	9.9257608145405e-18	3.8147595512312e-18	KLF4/ABCD1/EDN1/BCL2/PINK1/MTOR/HSP90AA1/HSP90AB1/HDAC4/ICAM1/GADD45A/SNCA/PPARA/AGTR1/BRCA1/EGFR/LEP/CDKN1A/HBB/GRIN1/MMP3/IFNG/PDGFRB/AGT/CLU/SOD2/NOX4/CAV1/XDH/HP/IL10	31
BP	GO:0071900	regulation of protein serine/threonine kinase activity	47/365	492/18862	1.05250289446639e-19	1.36908187756541e-17	5.26178120392475e-18	NPPA/PTPRC/EDN1/RPS27A/IGF1R/IKBKG/HRAS/HTT/NF1/HSP90AB1/SORL1/HSPB1/MAPK1/GADD45A/SNCA/MAPK3/SRC/PIK3CG/EGFR/AGER/CCND1/ADRB2/TF/CXCR4/LRRK2/APOE/NRG1/CDKN1A/KITLG/BMP4/KIT/GHRL/DRD4/IFNG/IGF1/PDGFRB/AGT/TNFSF11/ADIPOQ/VEGFA/GHR/GDF15/CAV1/CDKN2A/CD40LG/UCHL1/BMP2	47
BP	GO:0050890	cognition	36/365	276/18862	1.07245618991559e-19	1.36908187756541e-17	5.26178120392475e-18	MEF2C/EP300/HTT/CEBPB/CLN3/NF1/MTOR/MECP2/MFSD2A/MAPK1/BCHE/NGF/CHD7/EGFR/AGER/FOS/APOE/B2M/NLGN3/JUN/GRIN1/KIT/TLR2/APP/SLC2A4/CNR1/NTRK1/GRIN2B/MME/AFF2/GRIA1/SLC6A1/GRIN2A/NRXN1/SLC6A4/DBH	36
BP	GO:0010038	response to metal ion	40/365	352/18862	1.43014203705228e-19	1.7822293861742e-17	6.84962765114512e-18	MMP9/CYBB/GNRH1/EDN1/BCL2/MAP1LC3A/DNMT3A/MEF2C/NEDD4L/PARP1/ATP7A/ATP13A2/ATF4/ICAM1/MAPK1/SNCA/CD14/MAPK3/EGFR/FOS/VCAM1/CCND1/TF/LRRK2/B2M/JUN/BGLAP/ANK3/KIT/TXNIP/APP/TERT/RYR2/CASQ2/SOD2/CYP1A1/CAV1/SCN5A/SHH/NQO1	40
BP	GO:0055074	calcium ion homeostasis	45/365	454/18862	1.58171745788411e-19	1.91652482900125e-17	7.36576423027852e-18	CCR5/EDNRB/CCL5/TRPM1/PTPRC/EDN1/CD4/BCL2/HTT/ATP13A2/CLN3/ATF4/VAPB/P2RX7/GJA1/SNCA/ANK2/CHD7/AGTR1/PIK3CG/DDIT3/HMGB1/DMPK/CXCR4/APOE/CXCL12/FASLG/GRIN1/ITPR1/GHRL/BAX/APP/DRD4/RYR2/CASQ2/TNFSF11/CNR1/HTR2C/GRIN2B/GRIA1/CAV1/TRPV4/CALCR/NOS1/GRIN2A	45
BP	GO:0043523	regulation of neuron apoptotic process	31/365	197/18862	1.61114047527809e-19	1.91652482900125e-17	7.36576423027852e-18	STXBP1/BCL2/HRAS/MEF2C/NUPR1/PARP1/PINK1/CTNNB1/CEBPB/CLN3/NF1/DNAJC5/MECP2/HSP90AB1/ATF4/HDAC4/ATM/NGF/BCL2L11/DDIT3/APOE/FASLG/JUN/CCL2/BAX/TERT/GDNF/SOD2/NTRK1/IL10/NQO1	31
BP	GO:0072507	divalent inorganic cation homeostasis	47/365	499/18862	1.87557266736263e-19	2.18149940910578e-17	8.38413887094735e-18	CCR5/EDNRB/CCL5/TRPM1/PTPRC/EDN1/CD4/BCL2/HTT/ATP13A2/CLN3/ATF4/VAPB/P2RX7/GJA1/SNCA/ANK2/CHD7/AGTR1/PIK3CG/DDIT3/EGFR/HMGB1/DMPK/CXCR4/APOE/CXCL12/FASLG/GRIN1/ANK3/ITPR1/GHRL/BAX/APP/DRD4/RYR2/CASQ2/TNFSF11/CNR1/HTR2C/GRIN2B/GRIA1/CAV1/TRPV4/CALCR/NOS1/GRIN2A	47
BP	GO:0097191	extrinsic apoptotic signaling pathway	32/365	217/18862	3.06120597864964e-19	3.48312002005483e-17	1.33866467395869e-17	COL2A1/GABARAP/PTPRC/SORT1/BCL2/HTT/GSK3B/TNFRSF1A/P2RX7/ICAM1/NGF/SRC/BCL2L11/BRCA1/ATF3/FAS/KITLG/AR/FASLG/HSPA1B/BMP4/HSPA1A/BAX/TERT/KRT8/IFNG/IGF1/SERPINE1/AGT/GDNF/CAV1/DBH	32
BP	GO:0071496	cellular response to external stimulus	37/365	303/18862	3.129381661994e-19	3.48493268486736e-17	1.33936133394637e-17	XBP1/CBS/GABARAP/PTPRC/BCL2/MAP1LC3A/EIF2AK2/DAG1/ATP1A1/MTOR/ATF4/HNRNPA1/WDR45/MFSD2A/TNFRSF1A/HDAC4/GJA1/ICAM1/MAPK1/GADD45A/PPARA/MAPK3/PPARG/LAMP2/EGFR/UCP2/ATF3/SLC2A1/FOS/VCAM1/LEP/FAS/LRRK2/CDKN1A/JUN/BGLAP/LPL	37
BP	GO:0006874	cellular calcium ion homeostasis	44/365	442/18862	3.49703158235685e-19	3.81322152126162e-17	1.46553231444823e-17	CCR5/EDNRB/CCL5/TRPM1/PTPRC/EDN1/CD4/BCL2/HTT/ATP13A2/CLN3/ATF4/VAPB/P2RX7/GJA1/SNCA/ANK2/CHD7/AGTR1/PIK3CG/DDIT3/HMGB1/DMPK/CXCR4/APOE/CXCL12/FASLG/GRIN1/ITPR1/GHRL/BAX/APP/DRD4/RYR2/CASQ2/CNR1/HTR2C/GRIN2B/GRIA1/CAV1/TRPV4/CALCR/NOS1/GRIN2A	44
BP	GO:0051090	regulation of DNA-binding transcription factor activity	44/365	444/18862	4.16479222524258e-19	4.44867806263666e-17	1.70975680825748e-17	KLF4/EDN1/RPS27A/NFKBIA/IKBKG/EIF2AK2/NUPR1/PINK1/CTNNB1/EP300/CLOCK/TRAPPC9/HDAC4/ICAM1/MAPK1/IL18/MAPK3/PPARG/DDIT3/AGER/FOS/IL6/AR/JUN/HSPA1B/KIT/HSPA1A/TLR2/CSF3/APP/NLRP3/AGT/CLU/TNFSF11/VEGFA/NTRK1/CAMK2A/CAV1/ESR2/CDKN2A/RELN/CD40LG/SHH/IL10	44
BP	GO:0019932	second-messenger-mediated signaling	37/365	307/18862	4.89437461350741e-19	5.12343134541956e-17	1.96908418661319e-17	CCR5/NPPA/EDNRB/PTPRC/EDN1/CD4/NDUFS4/HTT/MTOR/GSK3B/P2RX7/HDAC4/ANK2/AGTR1/EGFR/VCAM1/DMPK/CXCR4/LRRK2/APOE/AHR/KDR/GRIN1/ITPR1/IGF1/AGT/RYR2/CASQ2/TNFSF11/VEGFA/CHRM3/HTR2C/GRIN2B/NOS2/P2RY12/NOS1/GRIN2A	37
BP	GO:0006816	calcium ion transport	42/365	409/18862	7.55525754196735e-19	7.75376823032492e-17	2.97999941438588e-17	CCR5/NPPA/PLP1/CCL5/TRPM1/PTPRC/CD4/BCL2/PSEN2/CTNNB1/HTT/P2RX7/GJA1/ICAM1/SNCA/ANK2/CHD7/PIK3CG/SPG7/DDIT3/CXCR4/CXCL12/FASLG/GRIN1/CCL2/ITPR1/BAX/DRD4/PDGFRB/RYR2/CASQ2/HTR2C/CRHR1/GRIN2B/CAMK2A/GJC2/CAV1/TRPV4/CALCR/P2RY12/NOS1/GRIN2A	42
BP	GO:1903706	regulation of hemopoiesis	42/365	415/18862	1.29817798207e-18	1.30666606887584e-16	5.02189903590236e-17	XBP1/PTPRC/CD4/NFKBIA/MEF2C/AGO1/EP300/CEBPB/PRKDC/GLI3/MTOR/KMT2A/CREBBP/KMT2D/KMT2C/IL18/ETS1/HMGB1/CTLA4/AGER/FOS/P4HTM/PRKCA/B2M/KITLG/JUN/STAT1/HSPA1B/BGLAP/BMP4/HSPA1A/CSF3/HLA-DRB1/NLRP3/IFNG/MYC/TNFSF11/SOCS1/ADIPOQ/FBN1/SHH/IL10	42
BP	GO:0030099	myeloid cell differentiation	42/365	419/18862	1.8522205672539e-18	1.82915517905791e-16	7.02997716786931e-17	MMP9/CD4/NFKBIA/MEF2C/PARP1/AGO1/RPS6/EP300/CEBPB/PRKDC/MTOR/KMT2A/CREBBP/KMT2D/KMT2C/PPARG/ETS1/SRC/HMGB1/FOS/P4HTM/TF/PRKCA/B2M/KITLG/JUN/STAT1/HSPA1B/BGLAP/BMP4/KIT/HSPA1A/TLR2/CSF3/APP/HLA-DRB1/IFNG/MYC/TNFSF11/ADIPOQ/VEGFA/FBN1	42
BP	GO:0009314	response to radiation	43/365	447/18862	3.32420369351566e-18	3.22201520960388e-16	1.23831447530379e-16	MMP9/TRPM1/PTPRC/BCL2/DNMT3A/HRAS/PARP1/SMC1A/EP300/CLOCK/TXN/PRKDC/NF1/MTOR/MECP2/ATF4/CREBBP/ICAM1/GADD45A/ATM/BRCA1/EGFR/FOS/VCAM1/CCND1/CDKN1A/BRCA2/CXCL12/JUN/GRIN1/MMP3/KIT/BAX/APP/MMP2/MYC/SOD2/NTRK1/NOX4/MME/EGR1/GRIN2A/DBH	43
BP	GO:0010720	positive regulation of cell development	35/365	290/18862	4.42060713558506e-18	4.20681049957312e-16	1.61680004518718e-16	LRP2/L1CAM/BCL2/DAG1/CTNNB1/PRKDC/GLI3/MTOR/CUX1/NGF/PPARG/DICER1/CDKL5/CXCR4/IL6/NOTCH1/CXCL12/BMP4/NGFR/KIT/TLR2/IL1RAPL1/IFNG/TNFSF11/AURKA/ADIPOQ/VEGFA/GJC2/MME/FN1/FOXG1/RELN/BMP2/SHH/PROC	35
BP	GO:2001233	regulation of apoptotic signaling pathway	38/365	348/18862	4.81626589755398e-18	4.50148851924956e-16	1.73005340793715e-16	XBP1/COL2A1/MMP9/PTPRC/MIF/BCL2/NUPR1/PARP1/PINK1/HTT/GSK3B/HSPB1/ICAM1/GATA4/SRC/BCL2L11/BRCA1/DDIT3/ATF3/FAS/LRRK2/AR/CXCL12/FASLG/HSPA1B/BMP4/NGFR/HSPA1A/BAX/TERT/IGF1/SERPINE1/AGT/CLU/GDNF/SOD2/CAV1/DBH	38
BP	GO:0048545	response to steroid hormone	37/365	330/18862	5.61029743138108e-18	5.151631009798e-16	1.97992214060374e-16	SPP1/CYBB/GNRH1/EDN1/BCL2/ARNTL/ATP1A1/PARP1/EP300/CLOCK/KMT2D/HSD11B2/EIF4E/ICAM1/BCHE/PPARA/SRC/BCL2L11/BRCA1/EGFR/HMGB1/FOS/CCND1/CDKN1A/IL1RN/IL6/NOTCH1/AR/BGLAP/BMP4/TXNIP/TLR2/ADIPOQ/CAV1/ESR2/CALCR/IL10	37
BP	GO:1901653	cellular response to peptide	40/365	391/18862	6.20171739299845e-18	5.59651531637136e-16	2.15090416298004e-16	XBP1/KLF4/PIK3R2/EDN1/IGF1R/PARP1/PRKDC/GSK3B/SP1/ARID1B/SORL1/GJA1/ICAM1/CASP4/PPARG/AGTR1/SRC/BCL2L11/UCP2/AGER/VCAM1/ADRB2/LEP/BGLAP/NGFR/GHRL/APP/PRL/IGF1/LPL/SLC2A4/SOCS1/ADIPOQ/GHR/CRHR1/NR4A1/GDF15/CAMK2A/FBN1/CAV1	40
BP	GO:0072503	cellular divalent inorganic cation homeostasis	44/365	480/18862	8.23691137671651e-18	7.30711765181936e-16	2.80833856215972e-16	CCR5/EDNRB/CCL5/TRPM1/PTPRC/EDN1/CD4/BCL2/HTT/ATP13A2/CLN3/ATF4/VAPB/P2RX7/GJA1/SNCA/ANK2/CHD7/AGTR1/PIK3CG/DDIT3/HMGB1/DMPK/CXCR4/APOE/CXCL12/FASLG/GRIN1/ITPR1/GHRL/BAX/APP/DRD4/RYR2/CASQ2/CNR1/HTR2C/GRIN2B/GRIA1/CAV1/TRPV4/CALCR/NOS1/GRIN2A	44
BP	GO:0034976	response to endoplasmic reticulum stress	35/365	296/18862	8.53426139819848e-18	7.44472069302848e-16	2.86122342665918e-16	XBP1/PIK3R2/BCL2/NUPR1/UGGT1/ATF6/STUB1/DNAJC3/EP300/CEBPB/ATF4/GSK3B/VAPB/TARDBP/UBE2J1/MANF/CASP4/BCL2L11/UBQLN2/DDIT3/CFTR/ATF3/CCND1/LRRK2/CANX/JUN/DNAJC10/CCL2/THBS4/PPP1R15A/HSPA1A/ITPR1/BAX/CLU/CAV1	35
BP	GO:0022407	regulation of cell-cell adhesion	42/365	437/18862	8.70879396396747e-18	7.47243075531242e-16	2.87187321227642e-16	XBP1/KLF4/CCL5/GNRH1/PTPRC/CD4/CEBPB/GLI3/ICAM1/IL18/PPARA/ETS1/SRC/SOX2/HMGB1/CTLA4/AGER/VCAM1/LEP/PRKCA/IL1RN/IL6/NOTCH1/CXCL12/EPCAM/BMP4/CCL2/ANK3/HLA-DRB1/NLRP3/IFNG/IGF1/TNFSF11/SOCS1/ADIPOQ/VEGFA/CAV1/TRPV4/CD40LG/BMP2/SHH/IL10	42
BP	GO:1903409	reactive oxygen species biosynthetic process	24/365	123/18862	1.3146673211079e-17	1.10983367075463e-15	4.26541468699013e-16	KLF4/ABCD1/EDN1/MTOR/HSP90AA1/HSP90AB1/RORA/HDAC4/ICAM1/SNCA/PPARA/HBB/GRIN1/IFNG/CLU/SOD2/CYP1A1/NOX4/NOS2/CAV1/NOS1/IL10/NQO1/MPO	24
BP	GO:0070371	ERK1 and ERK2 cascade	36/365	320/18862	1.44666161628376e-17	1.20187728565542e-15	4.61916516076568e-16	KLF4/CCL5/PTPRC/MIF/CD4/HRAS/ICAM1/MAPK1/GATA4/MAPK3/SRC/EGFR/HMGB1/AGER/ATF3/TF/APOE/PRKCA/KDR/NOTCH1/FGFR2/BMP4/CCL2/APP/HLA-DRB1/IGF1/PDGFRB/MYC/TNFSF11/ADIPOQ/HTR2C/NTRK1/FN1/CALCR/BMP2/ERBB4	36
BP	GO:0010959	regulation of metal ion transport	32/365	247/18862	1.55372727732795e-17	1.25110901069761e-15	4.8083770477307e-16	NPPA/PLP1/CCL5/CD4/BCL2/PSEN2/CTNNB1/HTT/P2RX7/GJA1/ICAM1/SNCA/ANK2/CHD7/PIK3CG/CXCR4/CXCL12/GRIN1/CCL2/BAX/DRD4/PDGFRB/RYR2/CASQ2/CRHR1/CAMK2A/GJC2/CAV1/KCNH2/CALCR/P2RY12/NOS1	32
BP	GO:0051896	regulation of protein kinase B signaling	32/365	247/18862	1.55372727732795e-17	1.25110901069761e-15	4.8083770477307e-16	LRP2/KLF4/PIK3R2/IGF1R/DAG1/PINK1/TXN/MTOR/HSP90AA1/HSP90AB1/RTN4/IL18/GATA4/PPARA/SRC/PIK3CG/DDIT3/EGFR/LEP/NRG1/KITLG/FGFR2/KIT/CSF3/PDGFRB/TNFSF11/NTRK1/GDF15/CALCR/XDH/P2RY12/ERBB4	32
BP	GO:0050804	modulation of chemical synaptic transmission	40/365	405/18862	2.14257059666165e-17	1.69912340953441e-15	6.53022712953815e-16	CEL/EDN1/STXBP1/HRAS/MEF2C/PINK1/CLN3/MTOR/MECP2/ATF4/GSK3B/EIF4E/MAPK1/BCHE/NGF/SRC/EGFR/AGER/ADRB2/DMPK/LRRK2/APOE/NLGN3/GRIN1/CCL2/KIT/GHRL/APP/CDH2/ADIPOQ/CNR1/NTRK1/GRIN2B/CAMK2A/MME/GRIA1/GRIN2A/NRXN1/RELN/SLC6A4	40
BP	GO:0099177	regulation of trans-synaptic signaling	40/365	406/18862	2.33610487175554e-17	1.81984259353258e-15	6.99418618394056e-16	CEL/EDN1/STXBP1/HRAS/MEF2C/PINK1/CLN3/MTOR/MECP2/ATF4/GSK3B/EIF4E/MAPK1/BCHE/NGF/SRC/EGFR/AGER/ADRB2/DMPK/LRRK2/APOE/NLGN3/GRIN1/CCL2/KIT/GHRL/APP/CDH2/ADIPOQ/CNR1/NTRK1/GRIN2B/CAMK2A/MME/GRIA1/GRIN2A/NRXN1/RELN/SLC6A4	40
BP	GO:0045471	response to ethanol	24/365	126/18862	2.3643350470045e-17	1.81984259353258e-15	6.99418618394056e-16	CYBB/GNRH1/DNMT3A/ICAM1/PPARA/CD14/CYP2E1/VCAM1/CCND1/LEP/FGFR2/BGLAP/GRIN1/CSF3/DRD4/NLRP3/SLC2A4/SOD2/ADIPOQ/CNR1/GRIN2B/GRIN2A/NQO1/DBH	24
BP	GO:2000379	positive regulation of reactive oxygen species metabolic process	22/365	101/18862	2.51896587898169e-17	1.91076339283916e-15	7.34362134970864e-16	KLF4/EDN1/MTOR/HSP90AA1/HSP90AB1/HDAC4/ICAM1/GADD45A/SNCA/AGTR1/EGFR/LEP/CDKN1A/HBB/GRIN1/IFNG/PDGFRB/AGT/CLU/SOD2/NOX4/XDH	22
BP	GO:0032147	activation of protein kinase activity	36/365	328/18862	3.22634388180984e-17	2.4123834110561e-15	9.27149347088513e-16	CCL5/PTPRC/RPS27A/IKBKG/EIF2AK2/PINK1/TXN/MTOR/MAPK1/GADD45A/IL18/NGF/MAPK3/SRC/EGFR/HMGB1/ADRB2/LEP/TF/CXCR4/LRRK2/NRG1/BMP4/KIT/GHRL/DRD4/IGF1/AGT/TNFSF11/SOCS1/VEGFA/GHR/NTRK1/GDF15/CD40LG/BMP2	36
BP	GO:0018108	peptidyl-tyrosine phosphorylation	38/365	369/18862	3.5137165735977e-17	2.59025247129724e-15	9.95509617812485e-16	CCL5/PTPRC/MIF/CD4/IGF1R/EIF2AK2/MTOR/TNFRSF1A/ICAM1/IL18/MAPK3/SRC/EGFR/LEP/NRG1/KDR/IL6/KITLG/FGFR2/THBS4/KIT/GHRL/CSF3/APP/IFNG/IGF1/PDGFRB/AGT/SOCS1/ADIPOQ/VEGFA/GHR/NTRK1/NOX4/CAV1/IL24/RELN/ERBB4	38
BP	GO:1903131	mononuclear cell differentiation	40/365	411/18862	3.58539454204914e-17	2.60638264348406e-15	1.00170891372163e-15	XBP1/PTPRC/CD4/BCL2/RPS6/EP300/ATP7A/CEBPB/PRKDC/GLI3/MTOR/RORA/HDAC4/IL18/ATM/PPARG/CHD7/HMGB1/CTLA4/AGER/VCAM1/LEP/B2M/IL6/JUN/BMP4/KIT/BAX/LEPR/HLA-DRB1/NLRP3/IFNG/MYC/SOCS1/VEGFA/NTRK1/EGR1/CD40LG/SHH/IL10	40
BP	GO:0050679	positive regulation of epithelial cell proliferation	29/365	203/18862	3.69829227606888e-17	2.63258635832687e-15	1.01177976605648e-15	XBP1/AKT3/HRAS/ATP7A/MTOR/SP1/RTN4/AGTR1/EGFR/HMGB1/CCND1/PRKCA/KDR/NOTCH1/AR/CXCL12/FGFR2/DLX5/BMP4/THBS4/GHRL/IGF1/MYC/VEGFA/NR4A1/SCN5A/BMP2/SHH/IL10	29
BP	GO:0018105	peptidyl-serine phosphorylation	35/365	310/18862	3.72203650202882e-17	2.63258635832687e-15	1.01177976605648e-15	MIF/BCL2/AKT3/PINK1/NSD1/RPS6KA3/TXN/PRKDC/MTOR/HSP90AA1/HSP90AB1/GSK3B/MAPK1/GADD45A/SNCA/ATM/NGF/MAPK3/SRC/EGFR/DMPK/LRRK2/PRKCA/IL6/CSF3/BAX/APP/IFNG/AURKA/VEGFA/CAMK2A/CAV1/CALCR/IL24/NOS1	35
BP	GO:0071902	positive regulation of protein serine/threonine kinase activity	35/365	311/18862	4.12184546821235e-17	2.87649855741646e-15	1.10552234242159e-15	PTPRC/EDN1/RPS27A/IKBKG/HRAS/HSP90AB1/MAPK1/GADD45A/SNCA/MAPK3/SRC/PIK3CG/EGFR/AGER/CCND1/ADRB2/TF/CXCR4/LRRK2/NRG1/KITLG/KIT/GHRL/DRD4/IFNG/IGF1/PDGFRB/AGT/TNFSF11/ADIPOQ/VEGFA/GHR/GDF15/CD40LG/BMP2	35
BP	GO:1904645	response to amyloid-beta	17/365	51/18862	4.19221147044936e-17	2.88710984688578e-15	1.1096005706411e-15	MMP9/IGF1R/PARP1/GSK3B/GJA1/ICAM1/CASP4/BCL2L11/AGER/VCAM1/ADRB2/NGFR/MMP3/APP/MMP2/IGF1/CALCR	17
BP	GO:0051924	regulation of calcium ion transport	31/365	238/18862	4.33831893315148e-17	2.94893003845648e-15	1.13335987440225e-15	NPPA/PLP1/CCL5/CD4/BCL2/PSEN2/CTNNB1/HTT/P2RX7/GJA1/ICAM1/SNCA/ANK2/CHD7/PIK3CG/CXCR4/CXCL12/GRIN1/CCL2/BAX/DRD4/PDGFRB/RYR2/CASQ2/CRHR1/CAMK2A/GJC2/CAV1/CALCR/P2RY12/NOS1	31
BP	GO:0018212	peptidyl-tyrosine modification	38/365	372/18862	4.61344720814941e-17	3.09574137018641e-15	1.18978375368064e-15	CCL5/PTPRC/MIF/CD4/IGF1R/EIF2AK2/MTOR/TNFRSF1A/ICAM1/IL18/MAPK3/SRC/EGFR/LEP/NRG1/KDR/IL6/KITLG/FGFR2/THBS4/KIT/GHRL/CSF3/APP/IFNG/IGF1/PDGFRB/AGT/SOCS1/ADIPOQ/VEGFA/GHR/NTRK1/NOX4/CAV1/IL24/RELN/ERBB4	38
BP	GO:1901216	positive regulation of neuron death	21/365	92/18862	4.84557599157594e-17	3.21034743543145e-15	1.23383020918076e-15	NUPR1/PARP1/CTNNB1/NF1/MTOR/ATF4/GSK3B/HDAC4/SNCA/ATM/BCL2L11/DDIT3/FOS/FASLG/JUN/BAX/IFNG/CLU/GRIN2B/EGR1/NQO1	21
BP	GO:0048511	rhythmic process	34/365	294/18862	5.12007721947773e-17	3.3498105208433e-15	1.28742994295026e-15	GNRH1/ARNTL/RAI1/USP9X/EP300/CLOCK/PRKDC/MTOR/ATF4/KMT2A/GSK3B/CREBBP/TARDBP/SP1/SETX/HUWE1/RORA/PPARA/PPARG/ETS1/SRC/EGFR/LEP/AHR/JUN/NGFR/GHRL/DRD4/SERPINE1/ADIPOQ/NTRK1/NOS2/EGR1/SLC6A4	34
BP	GO:0018209	peptidyl-serine modification	36/365	333/18862	5.26130034007413e-17	3.39970938024049e-15	1.30660753084882e-15	MIF/BCL2/AKT3/PARP1/PINK1/NSD1/RPS6KA3/TXN/PRKDC/MTOR/HSP90AA1/HSP90AB1/GSK3B/MAPK1/GADD45A/SNCA/ATM/NGF/MAPK3/SRC/EGFR/DMPK/LRRK2/PRKCA/IL6/CSF3/BAX/APP/IFNG/AURKA/VEGFA/CAMK2A/CAV1/CALCR/IL24/NOS1	36
BP	GO:0001936	regulation of endothelial cell proliferation	27/365	177/18862	8.55191890283202e-17	5.45862726066131e-15	2.09790975909011e-15	AKT3/MEF2C/NF1/MTOR/SP1/GJA1/PPARG/AGTR1/HMGB1/LEP/APOE/PRKCA/KDR/CXCL12/STAT1/BMP4/NGFR/CCL2/THBS4/GHRL/PRL/VEGFA/NR4A1/CAV1/XDH/BMP2/IL10	27
BP	GO:0051962	positive regulation of nervous system development	32/365	263/18862	1.00100632682829e-16	6.31237001761358e-15	2.42602801594022e-15	LRP2/L1CAM/DAG1/CTNNB1/GLI3/MTOR/CUX1/NGF/PPARG/DICER1/CDKL5/CXCR4/IL6/NOTCH1/NLGN3/CXCL12/NGFR/KIT/TLR2/GHRL/IL1RAPL1/IFNG/VEGFA/NTRK1/GJC2/MME/FN1/FOXG1/NRXN1/RELN/BMP2/SHH	32
BP	GO:1904062	regulation of cation transmembrane transport	36/365	340/18862	1.02760399448971e-16	6.40295155614182e-15	2.46084114469903e-15	NPPA/MMP9/PLP1/MEF2C/NEDD4L/PINK1/PSEN2/HTT/ATP7A/SNCA/ANK2/CHD7/PIK3CG/ADRB2/NLGN3/GRIN1/CCL2/ANK3/KCNQ1/BAX/APP/DRD4/IFNG/RYR2/CASQ2/CRHR1/GRIN2B/GJC2/GRIA1/CAV1/KCNH2/SCN5A/CALCR/NOS1/GRIN2A/RELN	36
BP	GO:0009266	response to temperature stimulus	30/365	228/18862	1.06825383510659e-16	6.57793008582105e-15	2.52809050017176e-15	NFKBIA/STUB1/DNAJC3/EP300/MTOR/HSP90AA1/HSP90AB1/GSK3B/CREBBP/MAPK1/ATM/CD14/MAPK3/PPARG/UCP2/FOS/ADRB2/CXCR4/CDKN1A/CXCL12/HSPA1B/NGFR/HSPA1A/IGF1/LPL/SOD2/NTRK1/CAMK2A/TRPV4/NOS1	30
BP	GO:1901215	negative regulation of neuron death	28/365	195/18862	1.14890596010674e-16	6.99229511069616e-15	2.68734307192654e-15	STXBP1/BCL2/IKBKG/HRAS/MEF2C/PINK1/CEBPB/ATP13A2/CLN3/DNAJC5/MECP2/HSP90AB1/ATF4/GSK3B/SORL1/SNCA/PPARA/NGF/LRRK2/APOE/CCL2/CSF3/BAX/TERT/GDNF/SOD2/NTRK1/IL10	28
BP	GO:0032409	regulation of transporter activity	33/365	283/18862	1.17557913815996e-16	7.07239219440144e-15	2.71812671872195e-15	NPPA/MMP9/BCL2/MEF2C/NEDD4L/PINK1/HTT/ATP7A/KMT2A/GJA1/SNCA/ANK2/PPARG/CFTR/ADRB2/NLGN3/GRIN1/CCL2/ANK3/APP/DRD4/IFNG/RYR2/CASQ2/ADIPOQ/CHRM3/CRHR1/GRIN2B/GRIA1/CAV1/NOS1/GRIN2A/RELN	33
BP	GO:0007623	circadian rhythm	29/365	212/18862	1.22078418729287e-16	7.26089140487602e-15	2.79057246640751e-15	ARNTL/RAI1/USP9X/EP300/CLOCK/PRKDC/MTOR/ATF4/KMT2A/GSK3B/TARDBP/SETX/HUWE1/RORA/PPARA/PPARG/EGFR/LEP/AHR/JUN/NGFR/GHRL/DRD4/SERPINE1/ADIPOQ/NTRK1/NOS2/EGR1/SLC6A4	29
BP	GO:0048608	reproductive structure development	39/365	405/18862	1.30998163494445e-16	7.70386952505533e-15	2.96082188572305e-15	LRP2/SPP1/GNRH1/BCL2/NUPR1/RPS6/CEBPB/GLI3/HSP90AB1/GJA1/ICAM1/MAPK1/GATA4/ATM/MAPK3/PPARG/CHD7/SRC/BCL2L11/CCND1/LEP/BRCA2/NOTCH1/KITLG/AR/FGFR2/BMP4/KIT/GHRL/BAX/KRT8/PDGFRB/CYP19A1/VEGFA/NTRK1/MME/C3/SHH/IL10	39
BP	GO:0061458	reproductive system development	39/365	408/18862	1.68264511194549e-16	9.78551612880298e-15	3.76085942564658e-15	LRP2/SPP1/GNRH1/BCL2/NUPR1/RPS6/CEBPB/GLI3/HSP90AB1/GJA1/ICAM1/MAPK1/GATA4/ATM/MAPK3/PPARG/CHD7/SRC/BCL2L11/CCND1/LEP/BRCA2/NOTCH1/KITLG/AR/FGFR2/BMP4/KIT/GHRL/BAX/KRT8/PDGFRB/CYP19A1/VEGFA/NTRK1/MME/C3/SHH/IL10	39
BP	GO:0019722	calcium-mediated signaling	28/365	198/18862	1.72668579815254e-16	9.9312895247587e-15	3.81688439591615e-15	CCR5/EDNRB/PTPRC/EDN1/CD4/HTT/MTOR/GSK3B/P2RX7/HDAC4/ANK2/AGTR1/EGFR/VCAM1/DMPK/CXCR4/LRRK2/KDR/GRIN1/ITPR1/IGF1/RYR2/CASQ2/TNFSF11/CHRM3/GRIN2B/P2RY12/GRIN2A	28
BP	GO:0031668	cellular response to extracellular stimulus	30/365	235/18862	2.49198057810443e-16	1.41772025497811e-14	5.44871268278898e-15	XBP1/CBS/GABARAP/PTPRC/BCL2/MAP1LC3A/EIF2AK2/MTOR/ATF4/HNRNPA1/WDR45/MFSD2A/ICAM1/MAPK1/PPARA/MAPK3/PPARG/LAMP2/UCP2/ATF3/SLC2A1/FOS/VCAM1/LEP/FAS/LRRK2/CDKN1A/JUN/BGLAP/LPL	30
BP	GO:0048732	gland development	39/365	413/18862	2.54075312192847e-16	1.42992492905092e-14	5.49561880702354e-15	XBP1/BCL2/HRAS/DAG1/ATP7A/CEBPB/PRKDC/GLI3/NF1/RTN4/MAPK1/ATM/MAPK3/ETS1/SRC/BCL2L11/SOX2/EGFR/UCP2/CCND1/NRG1/IL6/BRCA2/NOTCH1/AR/FGFR2/BMP4/BAX/PRL/TNFSF11/AURKA/CYP1A1/VEGFA/CAV1/XDH/BMP2/SHH/IL10/ERBB4	39
BP	GO:0070661	leukocyte proliferation	34/365	312/18862	3.18003039434387e-16	1.77066798765913e-14	6.80519382261045e-15	CCL5/GNRH1/PTPRC/MIF/CD4/BCL2/MEF2C/RPS6/PURA/CEBPB/MAPK1/IL18/ATM/MAPK3/PIK3CG/HMGB1/CTLA4/AGER/VCAM1/LEP/AHR/CDKN1A/IL6/KITLG/BMP4/KIT/BAX/HLA-DRB1/IGF1/CLU/TNFSF11/CD40LG/SHH/IL10	34
BP	GO:0044706	multi-multicellular organism process	28/365	204/18862	3.81475497590486e-16	2.1017292151459e-14	8.07755873568331e-15	SPP1/NPPA/MMP9/GNRH1/EDN1/BCL2/AGO2/ATP7A/MTOR/HSD11B2/GJA1/MAPK1/MAPK3/ETS1/UCP2/SLC2A1/FOS/LEP/AR/GHRL/PRL/MMP2/ACSL4/CNR1/CYP1A1/VEGFA/CRHR1/SLC6A4	28
BP	GO:0045637	regulation of myeloid cell differentiation	31/365	258/18862	4.40328192523737e-16	2.40070599965546e-14	9.22661377097436e-15	CD4/NFKBIA/MEF2C/AGO1/EP300/CEBPB/PRKDC/MTOR/KMT2A/CREBBP/KMT2D/KMT2C/ETS1/HMGB1/FOS/P4HTM/PRKCA/B2M/KITLG/JUN/STAT1/HSPA1B/BGLAP/HSPA1A/CSF3/HLA-DRB1/IFNG/MYC/TNFSF11/ADIPOQ/FBN1	31
BP	GO:0051960	regulation of nervous system development	39/365	422/18862	5.25104279244585e-16	2.83339772944965e-14	1.08895743639327e-14	LRP2/SPP1/L1CAM/DAG1/ARNTL/CTNNB1/GLI3/NF1/MTOR/CUX1/RTN4/SORL1/NGF/PPARG/CHD7/DICER1/CDKL5/CXCR4/B2M/IL6/NOTCH1/NLGN3/CXCL12/NGFR/KIT/TLR2/GHRL/IL1RAPL1/IFNG/VEGFA/NTRK1/GJC2/MME/FN1/FOXG1/NRXN1/RELN/BMP2/SHH	39
BP	GO:0046883	regulation of hormone secretion	31/365	260/18862	5.48420984471699e-16	2.92901574767844e-14	1.12570623128401e-14	SPP1/CCL5/EDN1/ARNTL/CLOCK/TARDBP/GJA1/CHD7/AGTR1/CFTR/EGFR/UCP2/SLC2A1/PLA2G6/LEP/PRKCA/IL6/ITPR1/GHRL/ACSL4/HLA-DRB1/IFNG/AGT/CYP19A1/TNFSF11/ADIPOQ/CNR1/POMC/HTR2C/CRHR1/NOS2	31
BP	GO:0001935	endothelial cell proliferation	27/365	191/18862	6.1383181443386e-16	3.24524819873416e-14	1.24724359105062e-14	AKT3/MEF2C/NF1/MTOR/SP1/GJA1/PPARG/AGTR1/HMGB1/LEP/APOE/PRKCA/KDR/CXCL12/STAT1/BMP4/NGFR/CCL2/THBS4/GHRL/PRL/VEGFA/NR4A1/CAV1/XDH/BMP2/IL10	27
BP	GO:0048771	tissue remodeling	26/365	175/18862	6.26403644635324e-16	3.27859667602128e-14	1.26006038410327e-14	SPP1/MEF2C/ATP7A/NF1/P2RX7/GJA1/IL18/CHD7/SRC/EGFR/AGER/ADRB2/LEP/CST3/TF/PRKCA/IL6/BGLAP/THBS4/BAX/MMP2/LEPR/AGT/TNFSF11/CAV1/DBH	26
BP	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	31/365	262/18862	6.81631951881531e-16	3.53233825361182e-14	1.3575806774837e-14	CCL5/PTPRC/MIF/CD4/MTOR/TNFRSF1A/ICAM1/IL18/SRC/EGFR/LEP/NRG1/IL6/KITLG/THBS4/KIT/GHRL/CSF3/APP/IFNG/IGF1/AGT/SOCS1/ADIPOQ/VEGFA/GHR/NOX4/CAV1/IL24/RELN/ERBB4	31
BP	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	27/365	193/18862	8.01840178183679e-16	4.11454067903272e-14	1.58133806038082e-14	CCL5/PTPRC/MIF/CD4/MTOR/TNFRSF1A/ICAM1/IL18/SRC/LEP/NRG1/IL6/KITLG/THBS4/KIT/GHRL/CSF3/IFNG/IGF1/AGT/ADIPOQ/VEGFA/GHR/NOX4/IL24/RELN/ERBB4	27
BP	GO:0070374	positive regulation of ERK1 and ERK2 cascade	28/365	210/18862	8.19555771732492e-16	4.1646164167455e-14	1.60058362777802e-14	CCL5/PTPRC/MIF/CD4/HRAS/ICAM1/GATA4/MAPK3/SRC/EGFR/HMGB1/AGER/APOE/PRKCA/KDR/NOTCH1/FGFR2/BMP4/CCL2/APP/HLA-DRB1/PDGFRB/TNFSF11/HTR2C/NTRK1/CALCR/BMP2/ERBB4	28
BP	GO:0097193	intrinsic apoptotic signaling pathway	32/365	283/18862	8.51780985782893e-16	4.28675161498814e-14	1.64752374881691e-14	XBP1/MMP9/MIF/BCL2/HRAS/NUPR1/PARP1/PINK1/EP300/CEBPB/PRKDC/ATF4/TNFRSF1A/HSPB1/ATM/CASP4/SRC/BCL2L11/BRCA1/DDIT3/LRRK2/CDKN1A/BRCA2/CXCL12/DNAJC10/PPP1R15A/HSPA1A/ITPR1/BAX/CLU/SOD2/CAV1	32
BP	GO:0042110	T cell activation	41/365	474/18862	8.97536928307401e-16	4.47400788834375e-14	1.71949179949418e-14	XBP1/CCL5/GNRH1/PTPRC/CD4/BCL2/RPS6/ATP7A/CEBPB/PRKDC/GLI3/MTOR/RORA/ICAM1/IL18/CHD7/SRC/PIK3CG/HMGB1/CTLA4/AGER/VCAM1/LEP/B2M/IL6/BMP4/CCL2/KIT/BAX/LEPR/HLA-DRB1/NLRP3/IFNG/IGF1/TNFSF11/SOCS1/EGR1/CAV1/CD40LG/SHH/IL10	41
BP	GO:0051480	regulation of cytosolic calcium ion concentration	35/365	344/18862	9.65732478587392e-16	4.76853188011926e-14	1.83268596482672e-14	CCR5/EDNRB/TRPM1/PTPRC/EDN1/CD4/BCL2/HTT/CLN3/P2RX7/GJA1/SNCA/ANK2/CHD7/AGTR1/PIK3CG/DDIT3/HMGB1/CXCR4/FASLG/GRIN1/ITPR1/GHRL/BAX/RYR2/CASQ2/CNR1/HTR2C/GRIN2B/GRIA1/CAV1/TRPV4/CALCR/NOS1/GRIN2A	35
BP	GO:0043406	positive regulation of MAP kinase activity	29/365	230/18862	1.11567349977427e-15	5.45741597926964e-14	2.09744422830165e-14	PTPRC/EDN1/RPS27A/IKBKG/HRAS/MAPK1/GADD45A/MAPK3/SRC/PIK3CG/EGFR/AGER/TF/CXCR4/LRRK2/NRG1/KITLG/KIT/GHRL/DRD4/IGF1/PDGFRB/AGT/TNFSF11/VEGFA/GHR/GDF15/CD40LG/BMP2	29
BP	GO:0050767	regulation of neurogenesis	35/365	348/18862	1.37924826342786e-15	6.68424575072353e-14	2.56895071287586e-14	LRP2/SPP1/L1CAM/DAG1/ARNTL/CTNNB1/GLI3/NF1/MTOR/CUX1/RTN4/SORL1/NGF/PPARG/CHD7/DICER1/CDKL5/CXCR4/B2M/IL6/NOTCH1/CXCL12/NGFR/KIT/TLR2/IL1RAPL1/IFNG/VEGFA/GJC2/MME/FN1/FOXG1/RELN/BMP2/SHH	35
BP	GO:0071216	cellular response to biotic stimulus	29/365	233/18862	1.58020632652681e-15	7.58788982847828e-14	2.91624750361442e-14	XBP1/CCR5/EDNRB/CCL5/NFKBIA/MEF2C/SMC1A/CEBPB/GSK3B/ICAM1/MAPK1/IL18/CD14/MAPK3/SRC/BCL2L11/DDIT3/HMGB1/PRKCA/IL6/CCL2/TXNIP/TLR2/CSF3/NLRP3/SERPINE1/NOS2/IL24/IL10	29
BP	GO:0007204	positive regulation of cytosolic calcium ion concentration	33/365	310/18862	1.77086026632058e-15	8.42607512174719e-14	3.23838657314701e-14	CCR5/EDNRB/TRPM1/PTPRC/EDN1/CD4/BCL2/HTT/P2RX7/GJA1/SNCA/ANK2/CHD7/AGTR1/PIK3CG/DDIT3/HMGB1/CXCR4/FASLG/GRIN1/ITPR1/GHRL/BAX/RYR2/CASQ2/CNR1/HTR2C/GRIN2B/CAV1/TRPV4/CALCR/NOS1/GRIN2A	33
BP	GO:0050769	positive regulation of neurogenesis	28/365	217/18862	1.93496116877102e-15	9.12395203364644e-14	3.50660103700467e-14	LRP2/L1CAM/DAG1/CTNNB1/GLI3/MTOR/CUX1/NGF/PPARG/DICER1/CDKL5/CXCR4/IL6/NOTCH1/CXCL12/NGFR/KIT/TLR2/IL1RAPL1/IFNG/VEGFA/GJC2/MME/FN1/FOXG1/RELN/BMP2/SHH	28
BP	GO:0060402	calcium ion transport into cytosol	24/365	152/18862	2.06362635081893e-15	9.64376814302348e-14	3.706381537984e-14	CCR5/TRPM1/PTPRC/CD4/BCL2/HTT/P2RX7/SNCA/ANK2/CHD7/DDIT3/FASLG/GRIN1/ITPR1/BAX/RYR2/CASQ2/HTR2C/GRIN2B/CAV1/TRPV4/CALCR/NOS1/GRIN2A	24
BP	GO:0009914	hormone transport	33/365	312/18862	2.13950387578279e-15	9.90987901402398e-14	3.80865571180336e-14	SPP1/CCL5/EDN1/ARNTL/CLOCK/TARDBP/GJA1/CHD7/AGTR1/CFTR/EGFR/UCP2/SLC2A1/PLA2G6/LEP/PRKCA/IL1RN/IL6/ITPR1/GHRL/ACSL4/HLA-DRB1/IFNG/AGT/CYP19A1/TNFSF11/TTR/ADIPOQ/CNR1/POMC/HTR2C/CRHR1/NOS2	33
BP	GO:0031647	regulation of protein stability	32/365	295/18862	2.81813590374012e-15	1.29387046668209e-13	4.97272180244448e-14	STXBP1/BCL2/NEDD4L/HCFC1/PINK1/STUB1/USP9X/EP300/HTT/PRKDC/RPL5/HSP90AA1/HSP90AB1/CREBBP/TARDBP/RTN4/MAPK1/SNCA/ANK2/SRC/LAMP2/TF/LRRK2/CDKN1A/PPIB/HSPA1B/HSPA1A/TERT/IGF1/CLU/AURKA/BMP2	32
BP	GO:0030900	forebrain development	35/365	357/18862	3.01881360119756e-15	1.3739539468407e-13	5.28050598799865e-14	LRP2/ATP7A/GLI3/TRAPPC9/NF1/GSK3B/RTN4/MFSD2A/WDR62/CHD7/ETS1/SRC/SOX2/SLC2A1/CXCR4/LRRK2/B2M/NOTCH1/CXCL12/FGFR2/DLX5/BMP4/BAX/APP/SATB2/CDH2/SCN5A/FOXP2/P2RY12/FOXG1/RELN/BMP2/SHH/ERBB4/NPY	35
BP	GO:0009636	response to toxic substance	29/365	239/18862	3.11891595763329e-15	1.40727638984936e-13	5.40857386119529e-14	HBA1/CCL5/PTGS1/BCL2/DNMT3A/NUPR1/PINK1/ATP7A/TXN/ATF4/MAPK1/MAPK3/FOS/APOE/PRDX1/AHR/CDKN1A/HBB/TLR2/BAX/GSTM1/PDGFRB/SOD2/CYP1A1/GJC2/HP/SLC6A4/NQO1/MPO	29
BP	GO:0001659	temperature homeostasis	25/365	171/18862	3.39173367914768e-15	1.51729351082555e-13	5.83140176414865e-14	EDNRB/IGF1R/ARNTL/BSCL2/CEBPB/ATF4/DYNC1H1/GJA1/IL18/ALMS1/DDIT3/UCP2/ADRB2/LEP/CXCR4/NOTCH1/GHRL/LEPR/TNFSF11/ADIPOQ/CNR1/VEGFA/EGR1/CAV1/DBH	25
BP	GO:0016049	cell growth	40/365	470/18862	3.56898730748995e-15	1.58305759045783e-13	6.08415231455245e-14	SPP1/L1CAM/EDN1/BCL2/NEDD4L/CTNNB1/USP9X/RPS6KA3/MTOR/HSP90AA1/HSP90AB1/GSK3B/RTN4/MFSD2A/KMT2D/GJA1/GATA4/PPARA/NGF/PPARG/SLC9A6/AGTR1/CDKL5/EGFR/CXCR4/APOE/CDKN1A/NLGN3/CXCL12/HSPA1B/HSPA1A/APP/IGF1/AGT/AURKA/VEGFA/ADAM10/ESR2/FN1/CDKN2A	40
BP	GO:0051235	maintenance of location	33/365	319/18862	4.09868881193406e-15	1.80273422198848e-13	6.92843371924457e-14	CCR5/PTPRC/CD4/NFKBIA/BSCL2/PINK1/HTT/TXN/SORL1/GJA1/SNCA/PPARA/ANK2/PPARG/CHD7/DDIT3/LEP/APOE/IL6/ABCA1/FASLG/ANK3/ITPR1/BAX/LPL/RYR2/CASQ2/HTR2C/FBN1/CAV1/C3/NOS1/IL10	33
BP	GO:1905952	regulation of lipid localization	26/365	189/18862	4.2185659615586e-15	1.83490214343038e-13	7.0520644291283e-14	SPP1/EDN1/STXBP1/NFKBIA/PPARA/PPARG/AGTR1/CETP/LEP/FURIN/APOE/IL6/ABCA1/FASLG/GHRL/LPL/AGT/CYP19A1/TNFSF11/PLA2G4A/ADIPOQ/POMC/CRHR1/CAV1/C3/SHH	26
BP	GO:0031349	positive regulation of defense response	35/365	361/18862	4.24194037743745e-15	1.83490214343038e-13	7.0520644291283e-14	MATR3/CCL5/NFKBIA/IKBKG/HRAS/MEF2C/NUPR1/EP300/CLOCK/CEBPB/PRKDC/HSP90AA1/CREBBP/TNFRSF1A/GJA1/SNCA/IL18/MAPK3/ETS1/AGTR1/SRC/PIK3CG/EGFR/HMGB1/LRRK2/IL6/TLR2/APP/IFNG/SERPINE1/LPL/AGT/TNFSF11/CNR1/C3	35
BP	GO:2001234	negative regulation of apoptotic signaling pathway	28/365	224/18862	4.41866824030848e-15	1.89048164082763e-13	7.26567265776723e-14	XBP1/COL2A1/MMP9/MIF/BCL2/PINK1/HTT/GSK3B/HSPB1/ICAM1/GATA4/SRC/BRCA1/FAS/LRRK2/AR/CXCL12/FASLG/HSPA1B/BMP4/HSPA1A/BAX/TERT/IGF1/SERPINE1/CLU/GDNF/SOD2	28
BP	GO:0009896	positive regulation of catabolic process	39/365	450/18862	4.45084812059938e-15	1.89048164082763e-13	7.26567265776723e-14	LRP2/ABCD1/IKBKG/NUPR1/NEDD4L/PINK1/ATF6/STUB1/AGO2/HTT/HSP90AA1/GSK3B/TARDBP/HUWE1/P2RX7/SORL1/GJA1/SNCA/ATM/PPARA/MAPK3/BCL2L11/UBQLN2/HMGB1/ADRB2/FURIN/LRRK2/APOE/KDR/IL6/HSPA1B/HSPA1A/BAX/APP/IFNG/IGF1/CLU/AURKA/CAV1	39
BP	GO:0060401	cytosolic calcium ion transport	25/365	173/18862	4.47878722702763e-15	1.89048164082763e-13	7.26567265776723e-14	CCR5/TRPM1/PTPRC/CD4/BCL2/PSEN2/HTT/P2RX7/SNCA/ANK2/CHD7/DDIT3/FASLG/GRIN1/ITPR1/BAX/RYR2/CASQ2/HTR2C/GRIN2B/CAV1/TRPV4/CALCR/NOS1/GRIN2A	25
BP	GO:1901342	regulation of vasculature development	34/365	341/18862	4.64481294319465e-15	1.94487607557446e-13	7.47472634479577e-14	XBP1/KLF4/CYBB/AKT3/AGO1/CTNNB1/AGO2/NF1/GTF2I/MECP2/SP1/HSPB1/GADD45A/GATA4/PPARG/ETS1/BRCA1/HMGB1/LEP/CXCR4/PRKCA/KDR/IL6/FASLG/STAT1/THBS4/GHRL/TERT/PRL/SERPINE1/VEGFA/ADAM10/C3/IL10	34
BP	GO:0034764	positive regulation of transmembrane transport	27/365	207/18862	4.75655382966904e-15	1.96029942869982e-13	7.53400279195817e-14	NPPA/PLP1/OCLN/PINK1/HTT/P2RX7/SNCA/ANK2/CFTR/ADRB2/NLGN3/CCL2/ANK3/KCNQ1/BAX/TERT/DRD4/IFNG/IGF1/RYR2/ADIPOQ/GJC2/KCNH2/CALCR/C3/NOS1/RELN	27
BP	GO:0034767	positive regulation of ion transmembrane transport	27/365	207/18862	4.75655382966904e-15	1.96029942869982e-13	7.53400279195817e-14	NPPA/PLP1/OCLN/PINK1/HTT/P2RX7/SNCA/ANK2/CFTR/ADRB2/NLGN3/CCL2/ANK3/KCNQ1/BAX/TERT/DRD4/IFNG/IGF1/RYR2/ADIPOQ/GJC2/KCNH2/CALCR/C3/NOS1/RELN	27
BP	GO:0070372	regulation of ERK1 and ERK2 cascade	32/365	301/18862	5.01167824244555e-15	2.049306556325e-13	7.87608315897487e-14	KLF4/CCL5/PTPRC/MIF/CD4/HRAS/ICAM1/GATA4/MAPK3/SRC/EGFR/HMGB1/AGER/ATF3/APOE/PRKCA/KDR/NOTCH1/FGFR2/BMP4/CCL2/APP/HLA-DRB1/PDGFRB/TNFSF11/ADIPOQ/HTR2C/NTRK1/FN1/CALCR/BMP2/ERBB4	32
BP	GO:0046879	hormone secretion	32/365	302/18862	5.50867100492005e-15	2.2350685302133e-13	8.59002063680311e-14	SPP1/CCL5/EDN1/ARNTL/CLOCK/TARDBP/GJA1/CHD7/AGTR1/CFTR/EGFR/UCP2/SLC2A1/PLA2G6/LEP/PRKCA/IL1RN/IL6/ITPR1/GHRL/ACSL4/HLA-DRB1/IFNG/AGT/CYP19A1/TNFSF11/ADIPOQ/CNR1/POMC/HTR2C/CRHR1/NOS2	32
BP	GO:0034614	cellular response to reactive oxygen species	24/365	159/18862	5.87694026164587e-15	2.35383072298811e-13	9.04645840281215e-14	MMP9/KLF4/MAP1LC3A/PINK1/ATP7A/TXN/MTR/SETX/MAPK1/MAPK3/ETS1/SRC/EGFR/FOS/LRRK2/PRDX1/IL6/JUN/MMP3/MMP2/SOD2/IL10/NQO1/MPO	24
BP	GO:0051897	positive regulation of protein kinase B signaling	25/365	175/18862	5.89132259670315e-15	2.35383072298811e-13	9.04645840281215e-14	LRP2/PIK3R2/IGF1R/PINK1/TXN/MTOR/HSP90AA1/HSP90AB1/RTN4/IL18/SRC/PIK3CG/EGFR/LEP/NRG1/KITLG/FGFR2/KIT/CSF3/PDGFRB/TNFSF11/GDF15/CALCR/P2RY12/ERBB4	25
BP	GO:0042063	gliogenesis	31/365	283/18862	5.94507408381849e-15	2.35731195111409e-13	9.05983777845066e-14	LRP2/PLP1/DAG1/GLI3/NF1/MED12/MTOR/RTN4/MAPK1/MAPK3/PPARG/DICER1/SOX2/EGFR/AGER/CXCR4/IL6/NOTCH1/CCL2/TLR2/APP/LEPR/IFNG/CLU/CDH2/GJC2/P2RY12/FOXG1/RELN/BMP2/SHH	31
BP	GO:0052547	regulation of peptidase activity	39/365	455/18862	6.40248822023537e-15	2.5195957402039e-13	9.68354174030058e-14	MMP9/KLF4/PINK1/RPS6KA3/ATP13A2/XIAP/SORL1/SNCA/NGF/PPARG/SRC/BCL2L11/SOX2/HMGB1/SERPINA1/AGER/FURIN/CST3/FAS/SERPINA3/FASLG/GRIN1/C4A/CTSD/NGFR/BAX/APP/NLRP3/SERPINI1/SERPINE1/MYC/AGT/VEGFA/GRIN2B/CAV1/FN1/XDH/C3/GRIN2A	39
BP	GO:0007565	female pregnancy	25/365	177/18862	7.72005202484859e-15	3.01542927597444e-13	1.15891747207271e-13	SPP1/NPPA/MMP9/GNRH1/BCL2/AGO2/ATP7A/MTOR/HSD11B2/GJA1/MAPK1/MAPK3/ETS1/UCP2/SLC2A1/FOS/LEP/AR/GHRL/PRL/MMP2/ACSL4/CNR1/VEGFA/CRHR1	25
BP	GO:0010506	regulation of autophagy	33/365	328/18862	9.21295207586964e-15	3.55463914807771e-13	1.36615156204905e-13	PIK3R2/BCL2/IKBKG/NUPR1/PINK1/ATF6/EEF1A1/EP300/HTT/ATP13A2/CLN3/MTOR/GSK3B/HSPB1/SNCA/GATA4/ATM/MAPK3/BCL2L11/UBQLN2/DDIT3/HMGB1/ADRB2/LEP/LRRK2/KDR/ITPR1/LEPR/IFNG/RAB39B/GFAP/UCHL1/IL10	33
BP	GO:0022898	regulation of transmembrane transporter activity	30/365	268/18862	9.2363569762814e-15	3.55463914807771e-13	1.36615156204905e-13	NPPA/MMP9/BCL2/MEF2C/NEDD4L/PINK1/HTT/ATP7A/GJA1/SNCA/ANK2/CFTR/ADRB2/NLGN3/GRIN1/CCL2/ANK3/APP/DRD4/IFNG/RYR2/CASQ2/CHRM3/CRHR1/GRIN2B/GRIA1/CAV1/NOS1/GRIN2A/RELN	30
BP	GO:0043393	regulation of protein binding	26/365	196/18862	1.02740580460359e-14	3.92514013233225e-13	1.50854590287934e-13	MMP9/STUB1/EP300/HSP90AB1/GSK3B/HDAC4/SORL1/PPARA/MAPK3/SRC/ADRB2/LRRK2/APOE/B2M/CDKN1A/BMP4/CSF3/BAX/APP/TERT/TNFSF11/AURKA/ADIPOQ/CAV1/BMP2/IL10	26
BP	GO:0050729	positive regulation of inflammatory response	22/365	133/18862	1.14866848032323e-14	4.35661654058827e-13	1.6743748786405e-13	NFKBIA/NUPR1/CLOCK/CEBPB/TNFRSF1A/SNCA/IL18/ETS1/AGTR1/PIK3CG/EGFR/LRRK2/IL6/TLR2/APP/IFNG/SERPINE1/LPL/AGT/TNFSF11/CNR1/C3	22
BP	GO:0015850	organic hydroxy compound transport	30/365	271/18862	1.24786901332937e-14	4.69881037105461e-13	1.80588995416313e-13	SPP1/CEL/NFKBIA/PINK1/SNCA/AGTR1/CETP/CFTR/GRAMD1B/LEP/FURIN/APOE/ABCA1/CXCL12/GHRL/DRD4/AGT/CYP19A1/CLU/GDNF/ADIPOQ/CNR1/KCNA2/POMC/CRHR1/CAV1/P2RY12/NOS1/SHH/SLC6A4	30
BP	GO:0045765	regulation of angiogenesis	33/365	335/18862	1.69693733173541e-14	6.34412142450225e-13	2.43823100823036e-13	XBP1/KLF4/CYBB/AKT3/AGO1/CTNNB1/AGO2/NF1/GTF2I/MECP2/SP1/HSPB1/GADD45A/GATA4/PPARG/ETS1/BRCA1/HMGB1/LEP/CXCR4/PRKCA/KDR/IL6/FASLG/STAT1/THBS4/GHRL/TERT/PRL/SERPINE1/VEGFA/C3/IL10	33
BP	GO:0030098	lymphocyte differentiation	34/365	358/18862	1.96343312344823e-14	7.28837515470074e-13	2.80113527354205e-13	XBP1/PTPRC/CD4/BCL2/RPS6/EP300/ATP7A/PRKDC/GLI3/MTOR/RORA/HDAC4/IL18/ATM/CHD7/HMGB1/CTLA4/VCAM1/LEP/B2M/IL6/BMP4/KIT/BAX/LEPR/HLA-DRB1/NLRP3/IFNG/SOCS1/NTRK1/EGR1/CD40LG/SHH/IL10	34
BP	GO:0045785	positive regulation of cell adhesion	37/365	425/18862	2.03708301944962e-14	7.50851586183049e-13	2.88574177180743e-13	XBP1/CCL5/PTPRC/CD4/DAG1/GLI3/GSK3B/ICAM1/IL18/ATM/ETS1/SRC/SOX2/HMGB1/CTLA4/AGER/VCAM1/LEP/PRKCA/KDR/IL6/CXCL12/CCL2/ANK3/HLA-DRB1/NLRP3/IFNG/IGF1/TNFSF11/SOCS1/VEGFA/CAV1/FN1/P2RY12/CD40LG/SHH/IL10	37
BP	GO:0031960	response to corticosteroid	23/365	152/18862	2.07347315185661e-14	7.58920173204022e-13	2.91675170643945e-13	CYBB/GNRH1/EDN1/BCL2/PARP1/HSD11B2/EIF4E/ICAM1/BCHE/SRC/BCL2L11/EGFR/HMGB1/FOS/CCND1/CDKN1A/IL1RN/IL6/NOTCH1/BGLAP/ADIPOQ/CALCR/IL10	23
BP	GO:0001667	ameboidal-type cell migration	39/365	473/18862	2.27315535380522e-14	8.26228827903924e-13	3.17543850959194e-13	MMP9/EDNRB/KLF4/EDN1/AKT3/MEF2C/ZEB2/AGO2/CLN3/NF1/MTOR/MECP2/SP1/RTN4/HSPB1/GJA1/GADD45A/PPARG/ETS1/SRC/PIK3CG/HMGB1/APOE/PRKCA/KDR/NOTCH1/KITLG/BMP4/KIT/IFNG/AGT/GDNF/CDH2/VEGFA/NR4A1/FN1/P2RY12/SHH/ERBB4	39
BP	GO:0048661	positive regulation of smooth muscle cell proliferation	19/365	96/18862	2.5416869186921e-14	9.17461333271342e-13	3.52607165271914e-13	MMP9/CCL5/EDN1/MTOR/HDAC4/GJA1/IL18/DNMT1/EGFR/IL6/JUN/FGFR2/STAT1/BMP4/TERT/MMP2/IGF1/PDGFRB/IL10	19
BP	GO:0031331	positive regulation of cellular catabolic process	35/365	384/18862	2.74372273434051e-14	9.83605807639605e-13	3.7802841711065e-13	LRP2/ABCD1/IKBKG/NUPR1/PINK1/ATF6/STUB1/AGO2/HTT/HSP90AA1/GSK3B/TARDBP/P2RX7/SNCA/ATM/PPARA/MAPK3/BCL2L11/UBQLN2/HMGB1/ADRB2/FURIN/LRRK2/APOE/KDR/IL6/HSPA1B/HSPA1A/BAX/APP/IFNG/IGF1/CLU/AURKA/CAV1	35
BP	GO:0090257	regulation of muscle system process	28/365	243/18862	3.57233052735907e-14	1.27194408028554e-12	4.88845230059662e-13	NPPA/KLF4/EDN1/DAG1/ATP1A1/PARP1/MTOR/TNFRSF1A/HDAC4/GATA4/PPARA/ANK2/PIK3CG/ADRB2/DMPK/PRKCA/NOTCH1/KIT/KCNQ1/GHRL/IGF1/AGT/RYR2/CASQ2/CHRM3/CAV1/SCN5A/NOS1	28
BP	GO:0032368	regulation of lipid transport	23/365	156/18862	3.6827314982448e-14	1.30239301769009e-12	5.00547645316203e-13	SPP1/EDN1/STXBP1/NFKBIA/PPARA/PPARG/AGTR1/CETP/LEP/FURIN/APOE/ABCA1/FASLG/GHRL/AGT/CYP19A1/TNFSF11/PLA2G4A/ADIPOQ/POMC/CRHR1/CAV1/SHH	23
BP	GO:0045862	positive regulation of proteolysis	34/365	367/18862	4.06749920101175e-14	1.42881146430171e-12	5.49133943704236e-13	NUPR1/PINK1/STUB1/GSK3B/SNCA/NGF/PPARG/SRC/BCL2L11/UBQLN2/HMGB1/AGER/FURIN/FAS/LRRK2/APOE/FASLG/HSPA1B/GRIN1/CTSD/NGFR/HSPA1A/BAX/APP/NLRP3/IFNG/MYC/CLU/AURKA/GRIN2B/CAV1/FN1/XDH/GRIN2A	34
BP	GO:0003018	vascular process in circulatory system	28/365	245/18862	4.39913146845999e-14	1.53500360706131e-12	5.89946683244003e-13	LRP2/NPPA/EDNRB/OCLN/EDN1/MFSD2A/GJA1/ICAM1/AGTR1/SRC/EGFR/AGER/SLC2A1/ADRB2/LEP/APOE/LEPR/AGT/SLC2A4/SOD2/VEGFA/CHRM3/CAV1/TRPV4/SLC6A1/NOS1/SLC6A4/DBH	28
BP	GO:0007409	axonogenesis	38/365	460/18862	4.71465084282086e-14	1.63420413982281e-12	6.2807234302061e-13	SPP1/L1CAM/STXBP1/BCL2/DAG1/USP9X/GLI3/HSP90AA1/HSP90AB1/GSK3B/RTN4/MAPK1/NGF/MAPK3/SLC9A6/SRC/CDKL5/SPAST/CXCR4/APOE/PRKCA/NOTCH1/NLGN3/CXCL12/FGFR2/DLX5/NGFR/ANK3/APP/GDNF/CDH2/VEGFA/NTRK1/FN1/FOXG1/NRXN1/RELN/SHH	38
BP	GO:0031669	cellular response to nutrient levels	26/365	210/18862	5.45119745438677e-14	1.87707680764871e-12	7.21415397183734e-13	XBP1/GABARAP/BCL2/MAP1LC3A/EIF2AK2/MTOR/ATF4/HNRNPA1/WDR45/MFSD2A/ICAM1/MAPK1/PPARA/MAPK3/PPARG/LAMP2/UCP2/ATF3/SLC2A1/LEP/FAS/LRRK2/CDKN1A/JUN/BGLAP/LPL	26
BP	GO:1903037	regulation of leukocyte cell-cell adhesion	32/365	330/18862	6.69623950180974e-14	2.29072663741648e-12	8.8039309858675e-13	XBP1/KLF4/CCL5/GNRH1/PTPRC/CD4/CEBPB/GLI3/ICAM1/IL18/PPARA/ETS1/SRC/HMGB1/CTLA4/AGER/VCAM1/LEP/IL6/CXCL12/BMP4/CCL2/HLA-DRB1/NLRP3/IFNG/IGF1/TNFSF11/SOCS1/CAV1/CD40LG/SHH/IL10	32
BP	GO:0008217	regulation of blood pressure	24/365	177/18862	6.82708016296856e-14	2.32032062162191e-12	8.91766930378191e-13	NPPA/EDNRB/EDN1/PTGS1/ATP1A1/MECP2/HSD11B2/GJA1/PPARA/PPARG/AGTR1/ADRB2/LEP/HBB/AR/AGT/SOD2/ADIPOQ/CNR1/POMC/MME/NOS2/NOS1/NPY	24
BP	GO:0060249	anatomical structure homeostasis	38/365	466/18862	7.09809606585853e-14	2.39686676185184e-12	9.21185845966427e-13	COL2A1/SPP1/OCLN/BCL2/AKT3/PARP1/PRKDC/NF1/HSP90AA1/HSP90AB1/HNRNPA1/MFSD2A/P2RX7/HSPB1/GJA1/MAPK1/ATM/MAPK3/SRC/LAMP2/EGFR/SLC2A1/ADRB2/TF/PRKCA/B2M/PRDX1/IL6/BRCA2/NOTCH1/SERPINA3/BGLAP/BAX/TERT/MYC/TNFSF11/CNR1/VEGFA	38
BP	GO:0030879	mammary gland development	21/365	132/18862	1.03944598325726e-13	3.48747453613366e-12	1.34033824156857e-12	XBP1/ATP7A/CEBPB/GLI3/RTN4/MAPK1/SRC/BCL2L11/CCND1/NRG1/BRCA2/AR/FGFR2/BMP4/BAX/PRL/TNFSF11/VEGFA/CAV1/XDH/ERBB4	21
BP	GO:0071241	cellular response to inorganic substance	26/365	216/18862	1.0693918051498e-13	3.5650934446841e-12	1.37016945332971e-12	MMP9/CYBB/EDN1/MAP1LC3A/MEF2C/PARP1/ATP7A/ATP13A2/MTR/ATF4/MAPK1/SNCA/MAPK3/EGFR/FOS/TF/LRRK2/B2M/JUN/ANK3/MMP3/APP/CYP1A1/SCN5A/SHH/NQO1	26
BP	GO:0052548	regulation of endopeptidase activity	36/365	426/18862	1.15326791256498e-13	3.82038243947158e-12	1.46828446429825e-12	MMP9/KLF4/RPS6KA3/ATP13A2/XIAP/SORL1/SNCA/NGF/PPARG/SRC/BCL2L11/SOX2/HMGB1/SERPINA1/AGER/FURIN/CST3/FAS/SERPINA3/FASLG/GRIN1/C4A/CTSD/NGFR/BAX/APP/NLRP3/SERPINI1/SERPINE1/MYC/AGT/VEGFA/GRIN2B/XDH/C3/GRIN2A	36
BP	GO:0007584	response to nutrient	23/365	165/18862	1.25925727189573e-13	4.14525318308318e-12	1.59314177199122e-12	XBP1/SPP1/CYBB/CD4/DNMT3A/MTOR/BCHE/GATA4/PPARG/EGFR/VCAM1/CCND1/MTHFR/LEP/BGLAP/ACSL4/LPL/SOD2/ADIPOQ/CNR1/CYP1A1/SLC6A4/NQO1	23
BP	GO:0048588	developmental cell growth	26/365	222/18862	2.0507649567107e-13	6.70567097038309e-12	2.57718505005774e-12	SPP1/L1CAM/EDN1/NEDD4L/CTNNB1/USP9X/MTOR/HSP90AA1/HSP90AB1/GSK3B/RTN4/KMT2D/GATA4/PPARA/NGF/SLC9A6/CDKL5/CXCR4/APOE/NLGN3/CXCL12/APP/IGF1/AURKA/VEGFA/FN1	26
BP	GO:0070663	regulation of leukocyte proliferation	27/365	241/18862	2.06269206387405e-13	6.70567097038309e-12	2.57718505005774e-12	CCL5/GNRH1/PTPRC/MIF/CD4/BCL2/MEF2C/CEBPB/MAPK1/IL18/ATM/MAPK3/HMGB1/CTLA4/AGER/VCAM1/LEP/AHR/CDKN1A/IL6/KITLG/BMP4/HLA-DRB1/IGF1/CD40LG/SHH/IL10	27
BP	GO:0002573	myeloid leukocyte differentiation	25/365	204/18862	2.13665125819495e-13	6.90323005271135e-12	2.65311277089705e-12	MMP9/CD4/PARP1/CEBPB/MTOR/PPARG/SRC/FOS/TF/PRKCA/KITLG/JUN/BGLAP/BMP4/KIT/TLR2/CSF3/APP/HLA-DRB1/IFNG/MYC/TNFSF11/ADIPOQ/VEGFA/FBN1	25
BP	GO:1990845	adaptive thermogenesis	22/365	153/18862	2.26795856566559e-13	7.28251235134583e-12	2.79888202711459e-12	IGF1R/ARNTL/BSCL2/CEBPB/ATF4/DYNC1H1/SORL1/GJA1/IL18/ALMS1/DDIT3/UCP2/ADRB2/LEP/CXCR4/NOTCH1/GHRL/LEPR/ADIPOQ/VEGFA/CAV1/DBH	22
BP	GO:0048639	positive regulation of developmental growth	23/365	170/18862	2.40793453791175e-13	7.68483498257933e-12	2.95350635555158e-12	L1CAM/EDN1/BCL2/MEF2C/NEDD4L/PRKDC/MTOR/MAPK1/NGF/CHD7/CDKL5/LEP/CXCR4/NOTCH1/PPIB/CXCL12/FGFR2/GHRL/IGF1/VEGFA/GHR/FN1/ERBB4	23
BP	GO:0006869	lipid transport	37/365	461/18862	2.51302142362656e-13	7.97160856440085e-12	3.06372181215333e-12	SPP1/CEL/ABCD1/EDN1/STXBP1/NFKBIA/CLN3/SCARB2/MFSD2A/P2RX7/GJA1/PPARA/PPARG/AGTR1/CETP/CFTR/SLC2A1/GRAMD1B/LEP/FURIN/APOE/ABCA1/FASLG/GHRL/ACSL4/DRD4/AGT/CYP19A1/CLU/TNFSF11/PLA2G4A/ADIPOQ/POMC/CRHR1/NOS2/CAV1/SHH	37
BP	GO:0014065	phosphatidylinositol 3-kinase signaling	22/365	154/18862	2.59979157670354e-13	8.14808928890198e-12	3.13154850493568e-12	KLF4/PIK3R2/CCL5/EDN1/IGF1R/NF1/MAPK1/IL18/MAPK3/SRC/PIK3CG/EGFR/LEP/KDR/KIT/CSF3/IGF1/PDGFRB/AGT/NTRK1/FN1/ERBB4	22
BP	GO:2001236	regulation of extrinsic apoptotic signaling pathway	22/365	154/18862	2.59979157670354e-13	8.14808928890198e-12	3.13154850493568e-12	COL2A1/PTPRC/BCL2/HTT/GSK3B/ICAM1/SRC/BRCA1/ATF3/FAS/AR/FASLG/HSPA1B/BMP4/HSPA1A/TERT/IGF1/SERPINE1/AGT/GDNF/CAV1/DBH	22
BP	GO:0070588	calcium ion transmembrane transport	30/365	304/18862	2.65326854525449e-13	8.26619497967976e-12	3.17693996865998e-12	CCR5/NPPA/PLP1/TRPM1/PTPRC/PSEN2/HTT/P2RX7/SNCA/ANK2/CHD7/PIK3CG/SPG7/DDIT3/FASLG/GRIN1/ITPR1/BAX/DRD4/RYR2/CASQ2/HTR2C/CRHR1/GRIN2B/GJC2/TRPV4/CALCR/P2RY12/NOS1/GRIN2A	30
BP	GO:0071248	cellular response to metal ion	24/365	189/18862	2.97438344238375e-13	9.21178872037666e-12	3.54035923911264e-12	MMP9/CYBB/EDN1/MAP1LC3A/MEF2C/PARP1/ATP7A/ATP13A2/ATF4/MAPK1/SNCA/MAPK3/EGFR/FOS/TF/LRRK2/B2M/JUN/ANK3/APP/CYP1A1/SCN5A/SHH/NQO1	24
BP	GO:0045787	positive regulation of cell cycle	34/365	395/18862	3.41184298206223e-13	1.05044624518316e-11	4.03717147908416e-12	EDN1/MIF/NUPR1/HCFC1/EP300/MECP2/HSP90AB1/BRD4/DYNC1H1/RAD21/EIF4E/GADD45A/ATM/SRC/BCL2L11/BRCA1/SPAST/EGFR/CCND1/PRKCA/CDKN1A/BRCA2/FGFR2/BAX/APP/TERT/IGF1/PDGFRB/AURKA/CYP1A1/ADAM10/FOXG1/IL10/SLC6A4	34
BP	GO:0008202	steroid metabolic process	31/365	329/18862	3.62714106671968e-13	1.11020212533397e-11	4.2668307654671e-12	LRP2/SPP1/CYP3A5/CEL/HSD11B1/ATP1A1/STUB1/MECP2/SP1/RORA/CYP2D6/HSD11B2/NFE2L1/CYP2E1/AGTR1/CETP/CFTR/LEP/APOE/ABCA1/KIT/APP/LEPR/IFNG/AGT/CYP19A1/CYP1A1/CYP17A1/EGR1/BMP2/SHH	31
BP	GO:0090066	regulation of anatomical structure size	38/365	493/18862	4.12059284354303e-13	1.2539059850642e-11	4.81912663648148e-12	SPP1/NPPA/L1CAM/EDNRB/EDN1/AKT3/ATP7A/ATP13A2/CLN3/MTOR/HSP90AB1/GSK3B/RTN4/P2RX7/GJA1/ICAM1/NGF/AGTR1/CDKL5/EGFR/ADRB2/LEP/LRRK2/APOE/ELN/CXCL12/PPP1R15A/CSF3/AGT/SOD2/VEGFA/CHRM3/CAV1/TRPV4/FN1/NOS1/SLC6A4/DBH	38
BP	GO:1904646	cellular response to amyloid-beta	13/365	41/18862	4.66112128922632e-13	1.41019126172315e-11	5.41977656447307e-12	IGF1R/PARP1/GSK3B/GJA1/ICAM1/CASP4/BCL2L11/AGER/VCAM1/ADRB2/NGFR/APP/IGF1	13
BP	GO:0002790	peptide secretion	34/365	401/18862	5.24715005899719e-13	1.57836686257421e-11	6.0661244783688e-12	CCL5/EDN1/ARNTL/CLOCK/ATP13A2/TARDBP/GJA1/CHD7/CFTR/EGFR/UCP2/SLC2A1/MIA2/PLA2G6/LEP/APOE/PRKCA/CANX/IL1RN/IL6/ABCA1/ITPR1/TLR2/GHRL/ACSL4/DRD4/HLA-DRB1/IFNG/IGF1/TNFSF11/CNR1/HTR2C/CRHR1/NOS2	34
BP	GO:1902893	regulation of pri-miRNA transcription by RNA polymerase II	14/365	51/18862	5.448030793289e-13	1.62942818126141e-11	6.26236802765431e-12	KLF4/HDAC4/PPARA/PPARG/ETS1/FOS/JUN/BMP4/NGFR/TERT/PRL/EGR1/BMP2/IL10	14
BP	GO:0019216	regulation of lipid metabolic process	34/365	402/18862	5.6328095856041e-13	1.67512075971886e-11	6.43797794144105e-12	ABCD1/BSCL2/ATP1A1/STUB1/MTOR/CREBBP/SP1/MFSD2A/RORA/TNFRSF1A/SORL1/PPARA/PPARG/AGTR1/SRC/PIK3CG/BRCA1/LEP/APOE/ABCA1/SERPINA3/KIT/IFNG/PDGFRB/AGT/ADIPOQ/CNR1/CYP1A1/HTR2C/EGR1/CAV1/P2RY12/C3/BMP2	34
BP	GO:0106106	cold-induced thermogenesis	21/365	144/18862	6.06228077081662e-13	1.7825830086772e-11	6.85098672562423e-12	IGF1R/ARNTL/BSCL2/CEBPB/ATF4/DYNC1H1/GJA1/IL18/ALMS1/DDIT3/UCP2/ADRB2/LEP/CXCR4/NOTCH1/GHRL/LEPR/ADIPOQ/VEGFA/CAV1/DBH	21
BP	GO:0120161	regulation of cold-induced thermogenesis	21/365	144/18862	6.06228077081662e-13	1.7825830086772e-11	6.85098672562423e-12	IGF1R/ARNTL/BSCL2/CEBPB/ATF4/DYNC1H1/GJA1/IL18/ALMS1/DDIT3/UCP2/ADRB2/LEP/CXCR4/NOTCH1/GHRL/LEPR/ADIPOQ/VEGFA/CAV1/DBH	21
BP	GO:0045927	positive regulation of growth	27/365	253/18862	6.68473132870775e-13	1.95463037846125e-11	7.51221497745399e-12	L1CAM/EDN1/BCL2/MEF2C/NEDD4L/RPS6KA3/PRKDC/MTOR/MFSD2A/MAPK1/NGF/CHD7/CDKL5/EGFR/LEP/CXCR4/NOTCH1/PPIB/CXCL12/FGFR2/GHRL/IGF1/VEGFA/ADAM10/GHR/FN1/ERBB4	27
BP	GO:0003012	muscle system process	36/365	453/18862	7.22964763237399e-13	2.10222087265808e-11	8.07944831898637e-12	NPPA/EDNRB/KLF4/EDN1/DAG1/NEDD4L/ATP1A1/PARP1/MTOR/TNFRSF1A/HDAC4/GJA1/GATA4/PPARA/ANK2/PIK3CG/SLC6A8/ADRB2/LEP/DMPK/CXCR4/PRKCA/NOTCH1/KIT/KCNQ1/GHRL/IGF1/AGT/RYR2/CASQ2/GDNF/CHRM3/CAV1/KCNH2/SCN5A/NOS1	36
BP	GO:0061614	pri-miRNA transcription by RNA polymerase II	14/365	52/18862	7.32577560534179e-13	2.11840384079331e-11	8.1416441883153e-12	KLF4/HDAC4/PPARA/PPARG/ETS1/FOS/JUN/BMP4/NGFR/TERT/PRL/EGR1/BMP2/IL10	14
BP	GO:0051047	positive regulation of secretion	29/365	295/18862	7.41828259271283e-13	2.13225999609266e-11	8.19489743686641e-12	XBP1/SPP1/EDNRB/EDN1/STXBP1/PINK1/ATP13A2/TARDBP/GJA1/SNCA/CFTR/EGFR/PLA2G6/LEP/CXCL12/TLR2/GHRL/PRL/ACSL4/HLA-DRB1/IFNG/IGF1/CYP19A1/TNFSF11/GDNF/PLA2G4A/CNR1/BMP2/SLC6A4	29
BP	GO:0071222	cellular response to lipopolysaccharide	24/365	197/18862	7.45516964625444e-13	2.13225999609266e-11	8.19489743686641e-12	XBP1/CCR5/EDNRB/CCL5/NFKBIA/MEF2C/CEBPB/ICAM1/MAPK1/IL18/CD14/MAPK3/SRC/HMGB1/PRKCA/IL6/CCL2/TLR2/CSF3/NLRP3/SERPINE1/NOS2/IL24/IL10	24
BP	GO:0022409	positive regulation of cell-cell adhesion	28/365	276/18862	8.65159160987471e-13	2.4610016568524e-11	9.45834757807241e-12	XBP1/CCL5/PTPRC/CD4/GLI3/ICAM1/IL18/ETS1/SRC/SOX2/HMGB1/CTLA4/AGER/VCAM1/LEP/IL6/CCL2/ANK3/HLA-DRB1/NLRP3/IFNG/IGF1/TNFSF11/SOCS1/CAV1/CD40LG/SHH/IL10	28
BP	GO:0032412	regulation of ion transmembrane transporter activity	27/365	257/18862	9.74109769788297e-13	2.75594082976862e-11	1.05918848936867e-11	NPPA/MMP9/MEF2C/NEDD4L/PINK1/HTT/ATP7A/ANK2/CFTR/ADRB2/NLGN3/GRIN1/CCL2/ANK3/APP/DRD4/IFNG/RYR2/CASQ2/CHRM3/CRHR1/GRIN2B/GRIA1/CAV1/NOS1/GRIN2A/RELN	27
BP	GO:0007159	leukocyte cell-cell adhesion	32/365	366/18862	1.14793975065868e-12	3.23027777147718e-11	1.24149001896364e-11	XBP1/KLF4/CCL5/GNRH1/PTPRC/CD4/CEBPB/GLI3/ICAM1/IL18/PPARA/ETS1/SRC/HMGB1/CTLA4/AGER/VCAM1/LEP/IL6/CXCL12/BMP4/CCL2/HLA-DRB1/NLRP3/IFNG/IGF1/TNFSF11/SOCS1/CAV1/CD40LG/SHH/IL10	32
BP	GO:0062012	regulation of small molecule metabolic process	35/365	437/18862	1.22787268262762e-12	3.4367302785417e-11	1.32083574247193e-11	ABCD1/NUPR1/PARP1/PINK1/EP300/CLN3/MTOR/GSK3B/SP1/MFSD2A/RORA/P2RX7/HDAC4/SNCA/PPARA/PPARG/SRC/BRCA1/HMGB1/LEP/APOE/KIT/APP/LEPR/IFNG/IGF1/ADIPOQ/CNR1/POMC/NOS2/EGR1/CAV1/NOS1/BMP2/NQO1	35
BP	GO:0046209	nitric oxide metabolic process	16/365	77/18862	1.30431683140175e-12	3.63127356146635e-11	1.39560440358832e-11	KLF4/EDN1/MTOR/HSP90AA1/HSP90AB1/RORA/ICAM1/HBB/TLR2/IFNG/CLU/NOS2/CAV1/NOS1/IL10/NQO1	16
BP	GO:0051051	negative regulation of transport	35/365	438/18862	1.31144642094556e-12	3.63180453292542e-11	1.39580847141574e-11	MMP9/EDN1/BCL2/NEDD4L/ATP7A/TXN/MTOR/ATF4/TNFRSF1A/UBE2J1/GJA1/ICAM1/SNCA/UBQLN2/UCP2/HMGB1/LEP/LRRK2/APOE/NRG1/NOTCH1/ANK3/TLR2/GHRL/DRD4/IL1RAPL1/CASQ2/ADIPOQ/CNR1/CRHR1/CAV1/KCNH2/P2RY12/NOS1/SHH	35
BP	GO:0046651	lymphocyte proliferation	28/365	282/18862	1.4670732110765e-12	4.0414006246181e-11	1.55322820297351e-11	CCL5/GNRH1/PTPRC/MIF/CD4/BCL2/MEF2C/RPS6/PURA/CEBPB/IL18/ATM/PIK3CG/HMGB1/CTLA4/AGER/VCAM1/LEP/AHR/CDKN1A/IL6/BMP4/BAX/HLA-DRB1/IGF1/CD40LG/SHH/IL10	28
BP	GO:2001057	reactive nitrogen species metabolic process	16/365	78/18862	1.61234165401528e-12	4.41832262676228e-11	1.6980903283677e-11	KLF4/EDN1/MTOR/HSP90AA1/HSP90AB1/RORA/ICAM1/HBB/TLR2/IFNG/CLU/NOS2/CAV1/NOS1/IL10/NQO1	16
BP	GO:0032943	mononuclear cell proliferation	28/365	285/18862	1.90031913137576e-12	5.18034913209414e-11	1.99095935310257e-11	CCL5/GNRH1/PTPRC/MIF/CD4/BCL2/MEF2C/RPS6/PURA/CEBPB/IL18/ATM/PIK3CG/HMGB1/CTLA4/AGER/VCAM1/LEP/AHR/CDKN1A/IL6/BMP4/BAX/HLA-DRB1/IGF1/CD40LG/SHH/IL10	28
BP	GO:0060560	developmental growth involved in morphogenesis	25/365	225/18862	1.98523548852063e-12	5.36060533448234e-11	2.06023707221925e-11	SPP1/L1CAM/NEDD4L/CTNNB1/USP9X/MED12/HSP90AA1/HSP90AB1/GSK3B/RTN4/NGF/SLC9A6/CDKL5/CXCR4/APOE/NOTCH1/NLGN3/CXCL12/FGFR2/BMP4/APP/AURKA/VEGFA/FN1/SHH	25
BP	GO:0035966	response to topologically incorrect protein	24/365	206/18862	1.98692670020935e-12	5.36060533448234e-11	2.06023707221925e-11	XBP1/UGGT1/ATF6/STUB1/DNAJC3/EP300/HSP90AA1/HSP90AB1/ATF4/VAPB/HSPB1/MANF/BCL2L11/DDIT3/ATF3/CCND1/CANX/HSPA1B/CCL2/THBS4/PPP1R15A/HSPA1A/BAX/CLU	24
BP	GO:0051099	positive regulation of binding	22/365	170/18862	2.015641226901e-12	5.41018778543582e-11	2.07929305511893e-11	MMP9/KLF4/PARP1/CTNNB1/EP300/TXN/HSP90AB1/GSK3B/NGF/PPARG/HMGB1/LRRK2/APOE/B2M/BMP4/CSF3/APP/TERT/IFNG/IGF1/CAV1/BMP2	22
BP	GO:0071214	cellular response to abiotic stimulus	30/365	330/18862	2.22564665342398e-12	5.91321552488380e-11	2.27262129558815e-11	MMP9/TRPM1/HRAS/DAG1/ATP1A1/PARP1/EP300/CLOCK/CLN3/ATF4/CREBBP/TNFRSF1A/HDAC4/GJA1/GADD45A/ATM/MAPK3/EGFR/SLC2A1/FAS/CDKN1A/MMP3/BAX/MMP2/MYC/SLC2A4/NOX4/MME/EGR1/TRPV4	30
BP	GO:0104004	cellular response to environmental stimulus	30/365	330/18862	2.22564665342398e-12	5.91321552488380e-11	2.27262129558815e-11	MMP9/TRPM1/HRAS/DAG1/ATP1A1/PARP1/EP300/CLOCK/CLN3/ATF4/CREBBP/TNFRSF1A/HDAC4/GJA1/GADD45A/ATM/MAPK3/EGFR/SLC2A1/FAS/CDKN1A/MMP3/BAX/MMP2/MYC/SLC2A4/NOX4/MME/EGR1/TRPV4	30
BP	GO:0030217	T cell differentiation	26/365	246/18862	2.26407656584769e-12	5.98493775032667e-11	2.30018623994414e-11	XBP1/PTPRC/CD4/BCL2/RPS6/ATP7A/PRKDC/GLI3/MTOR/RORA/IL18/CHD7/HMGB1/CTLA4/LEP/B2M/IL6/BMP4/KIT/LEPR/HLA-DRB1/NLRP3/IFNG/SOCS1/EGR1/SHH	26
BP	GO:0030072	peptide hormone secretion	26/365	247/18862	2.48636151743211e-12	6.5395056192159e-11	2.51332285628815e-11	CCL5/EDN1/ARNTL/CLOCK/TARDBP/GJA1/CHD7/CFTR/EGFR/UCP2/SLC2A1/PLA2G6/LEP/PRKCA/IL1RN/IL6/ITPR1/GHRL/ACSL4/HLA-DRB1/IFNG/TNFSF11/CNR1/HTR2C/CRHR1/NOS2	26
BP	GO:0071219	cellular response to molecule of bacterial origin	24/365	209/18862	2.72271740531791e-12	7.12535144971697e-11	2.73848050608554e-11	XBP1/CCR5/EDNRB/CCL5/NFKBIA/MEF2C/CEBPB/ICAM1/MAPK1/IL18/CD14/MAPK3/SRC/HMGB1/PRKCA/IL6/CCL2/TLR2/CSF3/NLRP3/SERPINE1/NOS2/IL24/IL10	24
BP	GO:0010001	glial cell differentiation	24/365	210/18862	3.02043274301479e-12	7.84781015041279e-11	3.01614246876472e-11	PLP1/DAG1/GLI3/NF1/MED12/MTOR/MAPK1/MAPK3/PPARG/DICER1/SOX2/EGFR/AGER/CXCR4/IL6/NOTCH1/TLR2/APP/IFNG/CLU/CDH2/RELN/BMP2/SHH	24
BP	GO:0009895	negative regulation of catabolic process	29/365	312/18862	3.02876891552041e-12	7.84781015041279e-11	3.01614246876472e-11	BCL2/BSCL2/NUPR1/PINK1/RPL5/ATP13A2/MTOR/HSP90AB1/TARDBP/MFSD2A/HDAC4/SORL1/SNCA/GATA4/PPARA/PIK3CG/EGFR/LEP/FURIN/CST3/LRRK2/LEPR/GDNF/CNR1/NOS2/GRIN2A/HP/SHH/IL10	29
BP	GO:0048015	phosphatidylinositol-mediated signaling	23/365	192/18862	3.23585599836164e-12	8.3430888154802e-11	3.206492513803e-11	KLF4/PIK3R2/CCL5/EDN1/IGF1R/NF1/MAPK1/IL18/NGF/MAPK3/SRC/PIK3CG/EGFR/LEP/KDR/KIT/CSF3/IGF1/PDGFRB/AGT/NTRK1/FN1/ERBB4	23
BP	GO:0009267	cellular response to starvation	21/365	157/18862	3.38287886057231e-12	8.67940586089973e-11	3.33574896932594e-11	XBP1/GABARAP/BCL2/MAP1LC3A/EIF2AK2/MTOR/ATF4/HNRNPA1/WDR45/MFSD2A/MAPK1/PPARA/MAPK3/LAMP2/UCP2/ATF3/SLC2A1/FAS/LRRK2/CDKN1A/JUN	21
BP	GO:0021537	telencephalon development	25/365	231/18862	3.58051693624731e-12	9.141671046009e-11	3.51341097056155e-11	GLI3/TRAPPC9/NF1/GSK3B/RTN4/MFSD2A/WDR62/CHD7/SLC2A1/CXCR4/LRRK2/CXCL12/DLX5/BMP4/BAX/CDH2/SCN5A/FOXP2/P2RY12/FOXG1/RELN/BMP2/SHH/ERBB4/NPY	25
BP	GO:1901654	response to ketone	23/365	193/18862	3.6095642204318e-12	9.17109666492234e-11	3.52472009465772e-11	SPP1/KLF4/CYBB/GNRH1/EDN1/PARP1/EIF4E/ICAM1/PPARG/SRC/CFTR/EGFR/FOS/CCND1/AHR/CDKN1A/AR/BGLAP/TXNIP/TLR2/CAV1/FOXP2/NQO1	23
BP	GO:1904064	positive regulation of cation transmembrane transport	20/365	141/18862	3.69334396517394e-12	9.338629137063e-11	3.58910771291503e-11	NPPA/PLP1/PINK1/HTT/SNCA/ANK2/ADRB2/NLGN3/CCL2/ANK3/KCNQ1/BAX/DRD4/IFNG/RYR2/GJC2/KCNH2/CALCR/NOS1/RELN	20
BP	GO:0042176	regulation of protein catabolic process	32/365	383/18862	3.88550980269438e-12	9.77728764774154e-11	3.75769698023733e-11	LRP2/NUPR1/NEDD4L/PINK1/STUB1/EEF1A1/RPL5/ATP13A2/HSP90AA1/HSP90AB1/GSK3B/HUWE1/SORL1/GJA1/SNCA/UBQLN2/EGFR/FURIN/CST3/LRRK2/APOE/HSPA1B/HSPA1A/IFNG/CLU/AURKA/NOS2/CAV1/GFAP/GRIN2A/SHH/IL10	32
BP	GO:0010742	macrophage derived foam cell differentiation	12/365	38/18862	3.96664643101825e-12	9.88639400949977e-11	3.7996297391859e-11	NFKBIA/EP300/IL18/PPARA/PPARG/AGTR1/CETP/ABCA1/STAT1/LPL/AGT/ADIPOQ	12
BP	GO:0090077	foam cell differentiation	12/365	38/18862	3.96664643101825e-12	9.88639400949977e-11	3.7996297391859e-11	NFKBIA/EP300/IL18/PPARA/PPARG/AGTR1/CETP/ABCA1/STAT1/LPL/AGT/ADIPOQ	12
BP	GO:0051092	positive regulation of NF-kappaB transcription factor activity	21/365	159/18862	4.33959571973328e-12	1.07138886778698e-10	4.1176600895781e-11	RPS27A/IKBKG/EIF2AK2/CLOCK/TRAPPC9/ICAM1/IL18/AGER/AR/HSPA1B/HSPA1A/TLR2/APP/NLRP3/AGT/CLU/TNFSF11/NTRK1/CAMK2A/CAV1/CD40LG	21
BP	GO:0051147	regulation of muscle cell differentiation	21/365	159/18862	4.33959571973328e-12	1.07138886778698e-10	4.1176600895781e-11	XBP1/EDN1/BCL2/MEF2C/CTNNB1/MTOR/MECP2/HDAC4/PPARA/DNMT1/DMPK/NRG1/NOTCH1/FGFR2/BMP4/KIT/IGF1/CDH2/SOD2/BMP2/SHH	21
BP	GO:0042692	muscle cell differentiation	31/365	362/18862	4.51971735576316e-12	1.11061974835983e-10	4.26843581263325e-11	XBP1/EDNRB/SORT1/EDN1/BCL2/MEF2C/CTNNB1/MTOR/MECP2/RORA/HDAC4/GATA4/PPARA/ANK2/DNMT1/DMPK/NRG1/NOTCH1/FGFR2/BMP4/KIT/KRT8/IGF1/PDGFRB/CDH2/SOD2/VEGFA/GDF15/NOS1/BMP2/SHH	31
BP	GO:2001257	regulation of cation channel activity	22/365	177/18862	4.59094331420931e-12	1.12285034142858e-10	4.31544155113329e-11	NPPA/MMP9/MEF2C/PINK1/HTT/ANK2/ADRB2/NLGN3/GRIN1/CCL2/ANK3/APP/DRD4/IFNG/CASQ2/CRHR1/GRIN2B/GRIA1/CAV1/NOS1/GRIN2A/RELN	22
BP	GO:1903039	positive regulation of leukocyte cell-cell adhesion	25/365	234/18862	4.77436747532254e-12	1.15723783584491e-10	4.44760272771078e-11	XBP1/CCL5/PTPRC/CD4/GLI3/ICAM1/IL18/ETS1/SRC/HMGB1/CTLA4/AGER/VCAM1/LEP/IL6/CCL2/HLA-DRB1/NLRP3/IFNG/IGF1/TNFSF11/SOCS1/CAV1/CD40LG/SHH	25
BP	GO:0120162	positive regulation of cold-induced thermogenesis	17/365	97/18862	4.77576179867217e-12	1.15723783584491e-10	4.44760272771078e-11	IGF1R/BSCL2/CEBPB/DYNC1H1/GJA1/IL18/ALMS1/UCP2/ADRB2/LEP/CXCR4/GHRL/LEPR/ADIPOQ/VEGFA/CAV1/DBH	17
BP	GO:0033135	regulation of peptidyl-serine phosphorylation	20/365	143/18862	4.82489446218658e-12	1.16375565046473e-10	4.47265259143272e-11	MIF/BCL2/PINK1/NSD1/TXN/HSP90AA1/HSP90AB1/GADD45A/SNCA/NGF/EGFR/IL6/CSF3/BAX/APP/IFNG/VEGFA/CAV1/CALCR/NOS1	20
BP	GO:0014066	regulation of phosphatidylinositol 3-kinase signaling	19/365	127/18862	4.90393161177844e-12	1.17739348880956e-10	4.52506678421468e-11	KLF4/CCL5/IGF1R/MAPK1/IL18/MAPK3/SRC/PIK3CG/EGFR/LEP/KDR/KIT/CSF3/IGF1/PDGFRB/AGT/NTRK1/FN1/ERBB4	19
BP	GO:0042594	response to starvation	23/365	196/18862	4.98939182987024e-12	1.18702167443367e-10	4.56207071142681e-11	XBP1/GABARAP/BCL2/MAP1LC3A/EIF2AK2/MTOR/ATF4/HNRNPA1/WDR45/MFSD2A/MAPK1/PPARA/MAPK3/PPARG/LAMP2/DDIT3/UCP2/ATF3/SLC2A1/FAS/LRRK2/CDKN1A/JUN	23
BP	GO:0048017	inositol lipid-mediated signaling	23/365	196/18862	4.98939182987024e-12	1.18702167443367e-10	4.56207071142681e-11	KLF4/PIK3R2/CCL5/EDN1/IGF1R/NF1/MAPK1/IL18/NGF/MAPK3/SRC/PIK3CG/EGFR/LEP/KDR/KIT/CSF3/IGF1/PDGFRB/AGT/NTRK1/FN1/ERBB4	23
BP	GO:0050867	positive regulation of cell activation	33/365	412/18862	5.58292443922461e-12	1.32221839433944e-10	5.08167116139949e-11	XBP1/CCL5/PTPRC/MIF/CD4/STXBP1/BCL2/MEF2C/PRKDC/GLI3/IL18/SRC/HMGB1/CTLA4/AGER/VCAM1/LEP/LRRK2/CDKN1A/IL6/CCL2/HLA-DRB1/NLRP3/IFNG/IGF1/PDGFRB/TNFSF11/SOCS1/PLA2G4A/CAV1/CD40LG/SHH/IL10	33
BP	GO:1903426	regulation of reactive oxygen species biosynthetic process	17/365	99/18862	6.73494476088642e-12	1.58786940894052e-10	6.10264553724701e-11	KLF4/ABCD1/EDN1/MTOR/HSP90AA1/HSP90AB1/HDAC4/ICAM1/SNCA/PPARA/HBB/GRIN1/IFNG/CLU/SOD2/CAV1/IL10	17
BP	GO:1902105	regulation of leukocyte differentiation	27/365	279/18862	6.82411164034732e-12	1.60167714464475e-10	6.15571269516344e-11	XBP1/PTPRC/CD4/CEBPB/PRKDC/GLI3/MTOR/IL18/HMGB1/CTLA4/AGER/FOS/PRKCA/KITLG/JUN/BGLAP/BMP4/HLA-DRB1/NLRP3/IFNG/MYC/TNFSF11/SOCS1/ADIPOQ/FBN1/SHH/IL10	27
BP	GO:0034103	regulation of tissue remodeling	16/365	86/18862	7.87432085629364e-12	1.83465187584292e-10	7.0511025777524e-11	SPP1/NF1/P2RX7/IL18/SRC/EGFR/AGER/LEP/CST3/TF/PRKCA/IL6/BGLAP/THBS4/LEPR/TNFSF11	16
BP	GO:0006809	nitric oxide biosynthetic process	15/365	73/18862	7.88682980635571e-12	1.83465187584292e-10	7.0511025777524e-11	KLF4/EDN1/MTOR/HSP90AA1/HSP90AB1/RORA/ICAM1/HBB/IFNG/CLU/NOS2/CAV1/NOS1/IL10/NQO1	15
BP	GO:0007569	cell aging	18/365	115/18862	8.21338148941934e-12	1.90216100511597e-10	7.31055986319533e-11	MIF/BCL2/AKT3/HRAS/ARNTL/PRKDC/MTOR/ICAM1/ATM/B2M/CDKN1A/BRCA2/BGLAP/TERT/SERPINE1/NOX4/MME/CDKN2A	18
BP	GO:0071375	cellular response to peptide hormone stimulus	29/365	325/18862	8.32587176412614e-12	1.91971862614256e-10	7.37803892476005e-11	XBP1/PIK3R2/EDN1/IGF1R/PARP1/PRKDC/GSK3B/SP1/ARID1B/SORL1/PPARG/AGTR1/SRC/UCP2/LEP/BGLAP/GHRL/PRL/LPL/SLC2A4/SOCS1/ADIPOQ/GHR/CRHR1/NR4A1/GDF15/CAMK2A/FBN1/CAV1	29
BP	GO:0060537	muscle tissue development	31/365	371/18862	8.5432319619126e-12	1.96119631967765e-10	7.53744980573175e-11	LRP2/EDN1/BCL2/MEF2C/ARNTL/NUPR1/EP300/NF1/MTOR/HDAC4/GJA1/MAPK1/GATA4/PPARA/CHD7/ATF3/FOS/NRG1/NOTCH1/ELN/FGFR2/BMP4/IGF1/PDGFRB/RYR2/VEGFA/EGR1/CAV1/BMP2/SHH/ERBB4	31
BP	GO:0050670	regulation of lymphocyte proliferation	24/365	221/18862	9.09575630343196e-12	2.07891652804205e-10	7.98988292156216e-11	CCL5/GNRH1/PTPRC/MIF/CD4/BCL2/MEF2C/CEBPB/IL18/ATM/HMGB1/CTLA4/AGER/VCAM1/LEP/AHR/CDKN1A/IL6/BMP4/HLA-DRB1/IGF1/CD40LG/SHH/IL10	24
BP	GO:0007259	receptor signaling pathway via JAK-STAT	21/365	166/18862	1.0076149805278e-11	2.29298122090543e-10	8.81259600818591e-11	CCL5/PTPRC/TNFRSF1A/GADD45A/IL18/LEP/IL6/NOTCH1/STAT1/CCL2/KIT/PRL/IFNG/IGF1/AGT/SOCS1/GHR/CAV1/IL24/IL10/ERBB4	21
BP	GO:0060326	cell chemotaxis	28/365	306/18862	1.06039587681041e-11	2.4026458957687e-10	9.23406935787056e-11	CCR5/EDNRB/CCL5/EDN1/MIF/HSPB1/MAPK1/MAPK3/AGTR1/PIK3CG/HMGB1/VCAM1/CXCR4/KDR/IL6/NOTCH1/PPIB/CXCL12/CCL2/THBS4/KIT/SERPINE1/PDGFRB/TNFSF11/VEGFA/ADAM10/NR4A1/IL10	28
BP	GO:0014706	striated muscle tissue development	30/365	351/18862	1.06607536604125e-11	2.40510278700858e-10	9.24351190791667e-11	LRP2/EDN1/BCL2/MEF2C/ARNTL/NUPR1/EP300/MTOR/HDAC4/GJA1/MAPK1/GATA4/PPARA/CHD7/ATF3/FOS/NRG1/NOTCH1/ELN/FGFR2/BMP4/IGF1/PDGFRB/RYR2/VEGFA/EGR1/CAV1/BMP2/SHH/ERBB4	30
BP	GO:0032944	regulation of mononuclear cell proliferation	24/365	223/18862	1.10330680718491e-11	2.47841537716987e-10	9.52527358721643e-11	CCL5/GNRH1/PTPRC/MIF/CD4/BCL2/MEF2C/CEBPB/IL18/ATM/HMGB1/CTLA4/AGER/VCAM1/LEP/AHR/CDKN1A/IL6/BMP4/HLA-DRB1/IGF1/CD40LG/SHH/IL10	24
BP	GO:0006986	response to unfolded protein	22/365	185/18862	1.1213711970578e-11	2.50822942111134e-10	9.63985765891796e-11	XBP1/ATF6/STUB1/DNAJC3/EP300/HSP90AA1/HSP90AB1/ATF4/VAPB/HSPB1/MANF/BCL2L11/DDIT3/ATF3/CCND1/CANX/HSPA1B/CCL2/THBS4/PPP1R15A/HSPA1A/BAX	22
BP	GO:0002791	regulation of peptide secretion	28/365	308/18862	1.23921300880400e-11	2.76001739918305e-10	1.06075523396392e-10	CCL5/ARNTL/CLOCK/ATP13A2/TARDBP/GJA1/CHD7/CFTR/EGFR/UCP2/SLC2A1/PLA2G6/LEP/APOE/PRKCA/IL6/ITPR1/TLR2/GHRL/ACSL4/DRD4/HLA-DRB1/IFNG/IGF1/TNFSF11/CNR1/HTR2C/NOS2	28
BP	GO:0097553	calcium ion transmembrane import into cytosol	19/365	134/18862	1.29879289835853e-11	2.88045848729175e-10	1.10704425903798e-10	CCR5/PTPRC/HTT/SNCA/ANK2/CHD7/DDIT3/FASLG/GRIN1/ITPR1/BAX/RYR2/CASQ2/HTR2C/GRIN2B/TRPV4/CALCR/NOS1/GRIN2A	19
BP	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	17/365	103/18862	1.30700519426584e-11	2.88312075380172e-10	1.10806744575249e-10	COL2A1/BCL2/HTT/GSK3B/ICAM1/SRC/BRCA1/FAS/AR/FASLG/HSPA1B/BMP4/HSPA1A/TERT/IGF1/SERPINE1/GDNF	17
BP	GO:0002696	positive regulation of leukocyte activation	32/365	401/18862	1.31101020138481e-11	2.88312075380172e-10	1.10806744575249e-10	XBP1/CCL5/PTPRC/MIF/CD4/STXBP1/BCL2/MEF2C/PRKDC/GLI3/IL18/SRC/HMGB1/CTLA4/AGER/VCAM1/LEP/LRRK2/CDKN1A/IL6/CCL2/HLA-DRB1/NLRP3/IFNG/IGF1/TNFSF11/SOCS1/PLA2G4A/CAV1/CD40LG/SHH/IL10	32
BP	GO:0060485	mesenchyme development	27/365	287/18862	1.3205778147024e-11	2.89201015989638e-10	1.11148390394022e-10	EDNRB/EDN1/BCL2/MEF2C/DAG1/CTNNB1/MTOR/GSK3B/RTN4/MAPK1/GATA4/MAPK3/NRG1/IL6/NOTCH1/KITLG/FGFR2/STAT1/BMP4/PDGFRB/MYC/GDNF/CDH2/FN1/BMP2/SHH/ERBB4	27
BP	GO:0046777	protein autophosphorylation	24/365	226/18862	1.46802673628243e-11	3.20152164070927e-10	1.23043819869988e-10	PTPRC/IGF1R/EIF2AK2/PINK1/ATP13A2/MTOR/GSK3B/ATM/MAPK3/SRC/CDKL5/EGFR/LRRK2/KDR/FGFR2/KIT/PDGFRB/AURKA/ADIPOQ/VEGFA/NTRK1/CAMK2A/CAV1/ERBB4	24
BP	GO:0042542	response to hydrogen peroxide	19/365	135/18862	1.48515512147345e-11	3.2121082255339e-10	1.23450693220346e-10	HBA1/KLF4/BCL2/MAP1LC3A/PINK1/TXN/SETX/ETS1/SRC/LRRK2/IL6/HBB/JUN/TXNIP/PDGFRB/SOD2/HP/IL10/NQO1	19
BP	GO:0043524	negative regulation of neuron apoptotic process	19/365	135/18862	1.48515512147345e-11	3.2121082255339e-10	1.23450693220346e-10	STXBP1/BCL2/HRAS/MEF2C/PINK1/CEBPB/CLN3/DNAJC5/MECP2/HSP90AB1/NGF/APOE/CCL2/BAX/TERT/GDNF/SOD2/NTRK1/IL10	19
BP	GO:0090276	regulation of peptide hormone secretion	23/365	209/18862	1.89603904873649e-11	4.08389645312212e-10	1.56956059005217e-10	CCL5/ARNTL/CLOCK/TARDBP/GJA1/CHD7/CFTR/EGFR/UCP2/SLC2A1/PLA2G6/LEP/PRKCA/IL6/ITPR1/GHRL/ACSL4/HLA-DRB1/IFNG/TNFSF11/CNR1/HTR2C/NOS2	23
BP	GO:1903532	positive regulation of secretion by cell	26/365	271/18862	2.05897441050758e-11	4.41666887893307e-10	1.69745474481449e-10	SPP1/EDN1/STXBP1/PINK1/ATP13A2/TARDBP/GJA1/SNCA/CFTR/EGFR/PLA2G6/LEP/CXCL12/TLR2/GHRL/ACSL4/HLA-DRB1/IFNG/IGF1/CYP19A1/TNFSF11/GDNF/PLA2G4A/CNR1/BMP2/SLC6A4	26
BP	GO:0048762	mesenchymal cell differentiation	24/365	231/18862	2.33853506108949e-11	4.97556606087089e-10	1.91225524250835e-10	EDNRB/EDN1/BCL2/MEF2C/DAG1/CTNNB1/MTOR/GSK3B/RTN4/MAPK1/MAPK3/NRG1/IL6/NOTCH1/KITLG/FGFR2/STAT1/BMP4/GDNF/CDH2/FN1/BMP2/SHH/ERBB4	24
BP	GO:0071453	cellular response to oxygen levels	24/365	231/18862	2.33853506108949e-11	4.97556606087089e-10	1.91225524250835e-10	CYBB/EDN1/RPS27A/BCL2/DNMT3A/PINK1/STUB1/EP300/ATP7A/MTOR/ATF4/CREBBP/RORA/ICAM1/PPARG/SRC/FAS/NOTCH1/TERT/MYC/SLC2A4/VEGFA/EGR1/CAV1	24
BP	GO:0002526	acute inflammatory response	17/365	107/18862	2.46045936112734e-11	5.19275979683085e-10	1.99572913374973e-10	EDNRB/NUPR1/CEBPB/ICAM1/PPARG/PIK3CG/SERPINA1/VCAM1/IL6/SERPINA3/NLRP3/TNFSF11/CNR1/FN1/C3/HP/MBL2	17
BP	GO:0033138	positive regulation of peptidyl-serine phosphorylation	17/365	107/18862	2.46045936112734e-11	5.19275979683085e-10	1.99572913374973e-10	MIF/BCL2/PINK1/TXN/HSP90AA1/HSP90AB1/SNCA/NGF/EGFR/IL6/CSF3/APP/IFNG/VEGFA/CAV1/CALCR/NOS1	17
BP	GO:0001501	skeletal system development	35/365	486/18862	2.48915168294502e-11	5.23221683073663e-10	2.01089362338107e-10	COL2A1/MMP9/PTPRC/EDN1/MEF2C/RAI1/CTNNB1/RPS6KA3/EP300/ATP7A/GLI3/MED12/HDAC4/GJA1/MAPK3/CHD7/SRC/LEP/PRDX1/PPIB/FGFR2/DLX5/BGLAP/BMP4/KIT/GHRL/SATB2/MMP2/IGF1/TNFSF11/FBN1/TRPV4/COL9A2/BMP2/SHH	35
BP	GO:0050870	positive regulation of T cell activation	23/365	212/18862	2.54267492902949e-11	5.32334423141614e-10	2.04591654289489e-10	XBP1/CCL5/PTPRC/CD4/GLI3/IL18/SRC/HMGB1/CTLA4/AGER/VCAM1/LEP/IL6/CCL2/HLA-DRB1/NLRP3/IFNG/IGF1/TNFSF11/SOCS1/CAV1/CD40LG/SHH	23
BP	GO:0048145	regulation of fibroblast proliferation	15/365	79/18862	2.63194986276771e-11	5.48829704451242e-10	2.1093127228975e-10	MIF/NUPR1/NDUFS4/CTNNB1/PRKDC/NF1/PPARG/CDKN1A/NGFR/BAX/IGF1/PDGFRB/MYC/AGT/FN1	15
BP	GO:0097696	receptor signaling pathway via STAT	21/365	175/18862	2.79740452314808e-11	5.81016479133216e-10	2.23301589128487e-10	CCL5/PTPRC/TNFRSF1A/GADD45A/IL18/LEP/IL6/NOTCH1/STAT1/CCL2/KIT/PRL/IFNG/IGF1/AGT/SOCS1/GHR/CAV1/IL24/IL10/ERBB4	21
BP	GO:0033555	multicellular organismal response to stress	14/365	67/18862	3.11672862433788e-11	6.44780933588319e-10	2.47808129856862e-10	EDNRB/BCL2/MEF2C/MECP2/GJA1/EIF4E/APOE/THBS4/DRD4/HTR2C/NTRK1/NOS1/RELN/DBH	14
BP	GO:0048144	fibroblast proliferation	15/365	80/18862	3.183014388803e-11	6.55901468936808e-10	2.52082076129405e-10	MIF/NUPR1/NDUFS4/CTNNB1/PRKDC/NF1/PPARG/CDKN1A/NGFR/BAX/IGF1/PDGFRB/MYC/AGT/FN1	15
BP	GO:0032868	response to insulin	26/365	278/18862	3.64883957463745e-11	7.48942209162841e-10	2.87840347869233e-10	XBP1/PIK3R2/SORT1/IGF1R/PARP1/PRKDC/MTOR/GSK3B/SP1/HSD11B2/SORL1/ICAM1/PPARA/PPARG/SRC/UCP2/SLC2A1/LEP/BGLAP/TLR2/LPL/SLC2A4/SOCS1/ADIPOQ/EGR1/IL10	26
BP	GO:0010212	response to ionizing radiation	19/365	142/18862	3.67458355118567e-11	7.51280090113507e-10	2.88738863746538e-10	PTPRC/BCL2/DNMT3A/HRAS/PARP1/CLOCK/PRKDC/ICAM1/GADD45A/ATM/BRCA1/VCAM1/CCND1/CDKN1A/BRCA2/BAX/MYC/NOX4/EGR1	19
BP	GO:0032680	regulation of tumor necrosis factor production	20/365	160/18862	3.94772915247759e-11	8.03984995489015e-10	3.08994897005311e-10	PTPRC/MIF/HSPB1/UBE2J1/CD14/DICER1/HMGB1/AGER/LEP/IL6/TLR2/GHRL/APP/IFNG/IGF1/LPL/CLU/ADIPOQ/POMC/IL10	20
BP	GO:0001822	kidney development	26/365	280/18862	4.2824366402664e-11	8.68770285858694e-10	3.33893774767404e-10	LRP2/MMP9/BCL2/MEF2C/CTNNB1/GLI3/NF1/AGTR1/BCL2L11/LRRK2/NOTCH1/FGFR2/STAT1/BMP4/BAX/PDGFRB/MYC/AGT/GDNF/ADIPOQ/VEGFA/FBN1/MME/EGR1/BMP2/SHH	26
BP	GO:0043254	regulation of protein-containing complex assembly	33/365	446/18862	4.67484550794754e-11	9.44715883729631e-10	3.63081884401047e-10	OCLN/STXBP1/EIF2AK2/HCFC1/PARP1/PINK1/STUB1/EP300/MTOR/MECP2/HSP90AA1/GSK3B/SORL1/ICAM1/SNCA/ATM/SRC/BCL2L11/HMGB1/APOE/NRG1/ELN/ABCA1/HSPA1B/MMP3/HSPA1A/CSF3/BAX/IFNG/CLU/VEGFA/P2RY12/GFAP	33
BP	GO:0001894	tissue homeostasis	25/365	260/18862	4.82978696249117e-11	9.72273267756875e-10	3.73672991308527e-10	COL2A1/SPP1/OCLN/BCL2/AKT3/NF1/MFSD2A/P2RX7/HSPB1/GJA1/SRC/EGFR/SLC2A1/ADRB2/TF/PRKCA/B2M/PRDX1/IL6/NOTCH1/SERPINA3/BGLAP/BAX/TNFSF11/VEGFA	25
BP	GO:0032640	tumor necrosis factor production	20/365	162/18862	4.96465797234964e-11	9.95594629397625e-10	3.82636071190166e-10	PTPRC/MIF/HSPB1/UBE2J1/CD14/DICER1/HMGB1/AGER/LEP/IL6/TLR2/GHRL/APP/IFNG/IGF1/LPL/CLU/ADIPOQ/POMC/IL10	20
BP	GO:0071692	protein localization to extracellular region	30/365	375/18862	5.53582074522327e-11	1.10589640383582e-09	4.25028262118187e-10	CCL5/ARNTL/CLOCK/ATP13A2/TARDBP/GJA1/CFTR/EGFR/UCP2/SLC2A1/MIA2/PLA2G6/LEP/APOE/PRKCA/CANX/IL1RN/IL6/ABCA1/ITPR1/TLR2/GHRL/ACSL4/DRD4/HLA-DRB1/IFNG/IGF1/CNR1/FBN1/NOS2	30
BP	GO:0001503	ossification	31/365	401/18862	6.21207079128664e-11	1.23356097706978e-09	4.7409348333374e-10	COL2A1/SPP1/MMP9/SORT1/BCL2/MEF2C/CEBPB/GLI3/NF1/ATF4/P2RX7/HDAC4/MAPK1/MAPK3/PPARG/SOX2/EGFR/ADRB2/LEP/IL6/NOTCH1/FGFR2/DLX5/BGLAP/BMP4/SATB2/MMP2/IGF1/TNFSF11/BMP2/SHH	31
BP	GO:1903555	regulation of tumor necrosis factor superfamily cytokine production	20/365	164/18862	6.22201180638943e-11	1.23356097706978e-09	4.7409348333374e-10	PTPRC/MIF/HSPB1/UBE2J1/CD14/DICER1/HMGB1/AGER/LEP/IL6/TLR2/GHRL/APP/IFNG/IGF1/LPL/CLU/ADIPOQ/POMC/IL10	20
BP	GO:0019233	sensory perception of pain	16/365	99/18862	7.3294338779294e-11	1.44763233649368e-09	5.56367354149874e-10	EDNRB/EDN1/MTOR/MECP2/P2RX7/MAPK1/MAPK3/CXCR4/CXCL12/CCL2/CNR1/KCNA2/NTRK1/MME/GRIN2A/IL10	16
BP	GO:0051251	positive regulation of lymphocyte activation	29/365	356/18862	7.61507694946841e-11	1.49839521629766e-09	5.7587701030606e-10	XBP1/CCL5/PTPRC/MIF/CD4/BCL2/MEF2C/PRKDC/GLI3/IL18/SRC/HMGB1/CTLA4/AGER/VCAM1/LEP/CDKN1A/IL6/CCL2/HLA-DRB1/NLRP3/IFNG/IGF1/TNFSF11/SOCS1/CAV1/CD40LG/SHH/IL10	29
BP	GO:0070665	positive regulation of leukocyte proliferation	19/365	148/18862	7.65666977225016e-11	1.50093668868754e-09	5.76853772315003e-10	CCL5/PTPRC/MIF/CD4/BCL2/MEF2C/MAPK1/IL18/MAPK3/HMGB1/AGER/VCAM1/LEP/CDKN1A/IL6/KITLG/IGF1/CD40LG/SHH	19
BP	GO:0072001	renal system development	26/365	288/18862	8.00932931837042e-11	1.56421006165488e-09	6.01171576096067e-10	LRP2/MMP9/BCL2/MEF2C/CTNNB1/GLI3/NF1/AGTR1/BCL2L11/LRRK2/NOTCH1/FGFR2/STAT1/BMP4/BAX/PDGFRB/MYC/AGT/GDNF/ADIPOQ/VEGFA/FBN1/MME/EGR1/BMP2/SHH	26
BP	GO:0071706	tumor necrosis factor superfamily cytokine production	20/365	167/18862	8.67489157449474e-11	1.68789526025671e-09	6.48707407507707e-10	PTPRC/MIF/HSPB1/UBE2J1/CD14/DICER1/HMGB1/AGER/LEP/IL6/TLR2/GHRL/APP/IFNG/IGF1/LPL/CLU/ADIPOQ/POMC/IL10	20
BP	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	29/365	358/18862	8.70779469257215e-11	1.68802212670084e-09	6.48756165984616e-10	LRP2/RPS27A/PARP1/STUB1/USP9X/EP300/XIAP/HSP90AB1/CREBBP/SORL1/GATA4/PPARA/MAPK3/PPARG/SRC/FOS/FURIN/TF/NOTCH1/JUN/DLX5/BMP4/HSPA1A/GDF15/FBN1/EGR1/CAV1/BMP2/SHH	29
BP	GO:0051222	positive regulation of protein transport	27/365	312/18862	9.00726226450113e-11	1.73963139086343e-09	6.68591112350424e-10	PIK3R2/BCL2/HRAS/PINK1/GLI3/ATP13A2/CLN3/HSP90AB1/GSK3B/TARDBP/HUWE1/SORL1/GJA1/MAPK1/SRC/CFTR/EGFR/PLA2G6/LEP/ANK3/TLR2/GHRL/ACSL4/HLA-DRB1/IFNG/IGF1/SHH	27
BP	GO:1904019	epithelial cell apoptotic process	17/365	116/18862	9.25050799001652e-11	1.78004260366715e-09	6.84122320778699e-10	SORT1/DNMT3A/NUPR1/MTOR/ICAM1/PPARA/PIK3CG/KDR/IL6/FASLG/CCL2/TERT/KRT8/SERPINE1/RYR2/CD40LG/IL10	17
BP	GO:1903522	regulation of blood circulation	26/365	290/18862	9.33378852529104e-11	1.78948897953748e-09	6.87752838705655e-10	NPPA/EDN1/ATP1A1/HDAC4/GJA1/ICAM1/GATA4/ANK2/AGTR1/PIK3CG/EGFR/AGER/LEP/DMPK/ITPR1/KCNQ1/GHRL/AGT/RYR2/CASQ2/CHRM3/CAV1/KCNH2/SCN5A/NOS1/DBH	26
BP	GO:0046425	regulation of receptor signaling pathway via JAK-STAT	16/365	101/18862	1.00102057718494e-10	1.91216850400949e-09	7.34902160199935e-10	CCL5/PTPRC/GADD45A/LEP/IL6/NOTCH1/KIT/PRL/IFNG/AGT/SOCS1/GHR/CAV1/IL24/IL10/ERBB4	16
BP	GO:0051899	membrane depolarization	15/365	87/18862	1.11676760158594e-10	2.12551331880029e-09	8.16896798710328e-10	ABCD1/EDN1/BCL2/NEDD4L/PARP1/P2RX7/ANK2/SRC/LRRK2/KDR/JUN/ANK3/CAV1/KCNH2/SCN5A	15
BP	GO:0060759	regulation of response to cytokine stimulus	21/365	189/18862	1.21165542468145e-10	2.29775525100823e-09	8.8309439991085e-10	KLF4/CCL5/PTPRC/EDN1/IKBKG/HSP90AB1/TNFRSF1A/CASP4/PPARG/IL1R1/CXCR4/IL1RN/IL6/STAT1/HSPA1B/HSPA1A/TLR2/IFNG/SOCS1/ADIPOQ/CAV1	21
BP	GO:0051928	positive regulation of calcium ion transport	17/365	118/18862	1.220802642717e-10	2.29797187190901e-09	8.83177653644816e-10	PLP1/CCL5/CD4/HTT/P2RX7/SNCA/ANK2/CXCL12/GRIN1/CCL2/BAX/PDGFRB/RYR2/CAMK2A/GJC2/CAV1/CALCR	17
BP	GO:0050808	synapse organization	31/365	412/18862	1.22458281121481e-10	2.29797187190901e-09	8.83177653644816e-10	L1CAM/CEL/IGF1R/MEF2C/DAG1/CLN3/MECP2/SNCA/CDKL5/DMPK/LRRK2/APOE/NLGN3/ANK3/TLR2/GHRL/APP/IL1RAPL1/GDNF/CDH2/GABRG2/ADAM10/NTRK1/GRIN2B/SLC6A1/RAB39B/C3/NRXN1/RELN/IL10/ERBB4	31
BP	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	13/365	61/18862	1.22494106278681e-10	2.29797187190901e-09	8.83177653644816e-10	XBP1/BCL2/CEBPB/ATF4/CASP4/BCL2L11/DDIT3/LRRK2/DNAJC10/PPP1R15A/HSPA1A/ITPR1/BAX	13
BP	GO:0051651	maintenance of location in cell	22/365	209/18862	1.25577760524055e-10	2.34740713779609e-09	9.02177069028081e-10	CCR5/PTPRC/CD4/PINK1/HTT/TXN/SORL1/GJA1/SNCA/ANK2/CHD7/DDIT3/APOE/FASLG/ANK3/ITPR1/BAX/RYR2/CASQ2/HTR2C/CAV1/NOS1	22
BP	GO:0051384	response to glucocorticoid	18/365	135/18862	1.28757249166701e-10	2.39827559479898e-09	9.21727301582938e-10	EDN1/BCL2/HSD11B2/EIF4E/ICAM1/BCHE/BCL2L11/EGFR/HMGB1/FOS/CCND1/CDKN1A/IL1RN/IL6/BGLAP/ADIPOQ/CALCR/IL10	18
BP	GO:2000116	regulation of cysteine-type endopeptidase activity	23/365	230/18862	1.33427245623974e-10	2.47644753048184e-09	9.51771057810428e-10	MMP9/KLF4/RPS6KA3/XIAP/SNCA/NGF/PPARG/SRC/BCL2L11/SOX2/HMGB1/FAS/FASLG/GRIN1/CTSD/NGFR/BAX/NLRP3/MYC/VEGFA/GRIN2B/XDH/GRIN2A	23
BP	GO:0060078	regulation of postsynaptic membrane potential	18/365	136/18862	1.45810738106547e-10	2.69672580653593e-09	1.0364304278282e-09	MEF2C/MECP2/GSK3B/P2RX7/ADRB2/DMPK/LRRK2/NLGN3/GRIN1/GHRL/APP/DRD4/GABRG2/GRIN2B/GRIA1/GRIN2A/NRXN1/RELN	18
BP	GO:0000187	activation of MAPK activity	19/365	154/18862	1.53961391638135e-10	2.81760113228671e-09	1.08288634310076e-09	PTPRC/RPS27A/IKBKG/MAPK1/MAPK3/TF/CXCR4/LRRK2/NRG1/KIT/GHRL/DRD4/IGF1/AGT/TNFSF11/GHR/GDF15/CD40LG/BMP2	19
BP	GO:1902107	positive regulation of leukocyte differentiation	19/365	154/18862	1.53961391638135e-10	2.81760113228671e-09	1.08288634310076e-09	XBP1/PTPRC/CD4/PRKDC/GLI3/IL18/HMGB1/AGER/FOS/PRKCA/KITLG/JUN/HLA-DRB1/NLRP3/IFNG/TNFSF11/SOCS1/SHH/IL10	19
BP	GO:1903708	positive regulation of hemopoiesis	19/365	154/18862	1.53961391638135e-10	2.81760113228671e-09	1.08288634310076e-09	XBP1/PTPRC/CD4/PRKDC/GLI3/IL18/HMGB1/AGER/FOS/PRKCA/KITLG/JUN/HLA-DRB1/NLRP3/IFNG/TNFSF11/SOCS1/SHH/IL10	19
BP	GO:0009306	protein secretion	29/365	367/18862	1.57305908750181e-10	2.86877744389702e-09	1.10255489316558e-09	CCL5/ARNTL/CLOCK/ATP13A2/TARDBP/GJA1/CFTR/EGFR/UCP2/SLC2A1/MIA2/PLA2G6/LEP/APOE/PRKCA/CANX/IL1RN/IL6/ABCA1/ITPR1/TLR2/GHRL/ACSL4/DRD4/HLA-DRB1/IFNG/IGF1/CNR1/NOS2	29
BP	GO:0001655	urogenital system development	27/365	320/18862	1.59713186066082e-10	2.90256533288151e-09	1.11554056495718e-09	LRP2/MMP9/BCL2/MEF2C/CTNNB1/GLI3/NF1/AGTR1/BCL2L11/LRRK2/NOTCH1/AR/FGFR2/STAT1/BMP4/BAX/PDGFRB/MYC/AGT/GDNF/ADIPOQ/VEGFA/FBN1/MME/EGR1/BMP2/SHH	27
BP	GO:0031099	regeneration	21/365	192/18862	1.6300289770186e-10	2.95210092239285e-09	1.13457853763706e-09	SPP1/KLF4/BCL2/DAG1/CEBPB/GLI3/MTR/GATA4/PPARG/SOX2/EGFR/UCP2/CCND1/CDKN1A/IL6/NOTCH1/CXCL12/IGF1/AURKA/IL10/ERBB4	21
BP	GO:0035592	establishment of protein localization to extracellular region	29/365	368/18862	1.67790594433373e-10	3.02833093539405e-09	1.16387595630554e-09	CCL5/ARNTL/CLOCK/ATP13A2/TARDBP/GJA1/CFTR/EGFR/UCP2/SLC2A1/MIA2/PLA2G6/LEP/APOE/PRKCA/CANX/IL1RN/IL6/ABCA1/ITPR1/TLR2/GHRL/ACSL4/DRD4/HLA-DRB1/IFNG/IGF1/CNR1/NOS2	29
BP	GO:0031334	positive regulation of protein-containing complex assembly	24/365	254/18862	1.70901594176392e-10	3.07387953236851e-09	1.18138161139839e-09	OCLN/PARP1/PINK1/STUB1/MTOR/MECP2/HSP90AA1/GSK3B/ICAM1/SNCA/ATM/SRC/BCL2L11/NRG1/ABCA1/HSPA1B/MMP3/HSPA1A/CSF3/BAX/IFNG/CLU/VEGFA/P2RY12	24
BP	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	11/365	40/18862	1.71570175905135e-10	3.07533664618998e-09	1.18194162276392e-09	KLF4/PPARG/ETS1/FOS/JUN/NGFR/TERT/PRL/EGR1/BMP2/IL10	11
BP	GO:0099565	chemical synaptic transmission, postsynaptic	16/365	105/18862	1.82689505107349e-10	3.26347054515996e-09	1.25424697057713e-09	MEF2C/MECP2/GSK3B/P2RX7/ADRB2/DMPK/LRRK2/NLGN3/GRIN1/GHRL/APP/DRD4/GRIN2B/GRIN2A/NRXN1/RELN	16
BP	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	15/365	90/18862	1.84340816699395e-10	3.28176814491372e-09	1.26127927215376e-09	CCL5/IGF1R/IL18/SRC/PIK3CG/LEP/KDR/KIT/CSF3/IGF1/PDGFRB/AGT/NTRK1/FN1/ERBB4	15
BP	GO:0046850	regulation of bone remodeling	12/365	51/18862	1.85490888848116e-10	3.29104851603742e-09	1.26484598961195e-09	SPP1/NF1/P2RX7/SRC/EGFR/LEP/TF/PRKCA/IL6/BGLAP/LEPR/TNFSF11	12
BP	GO:0009791	post-embryonic development	14/365	76/18862	1.86983889604722e-10	3.3063299938889e-09	1.27071910752e-09	KLF4/BCL2/AGO2/MTOR/MECP2/ATM/BCL2L11/FGFR2/BMP4/ITPR1/BAX/GABRG2/VEGFA/FBN1	14
BP	GO:0045766	positive regulation of angiogenesis	20/365	175/18862	2.03234848651768e-10	3.56956777799784e-09	1.37188907019968e-09	XBP1/KLF4/CYBB/AKT3/AGO2/SP1/HSPB1/GATA4/ETS1/BRCA1/HMGB1/CXCR4/PRKCA/KDR/GHRL/TERT/SERPINE1/VEGFA/C3/IL10	20
BP	GO:1904018	positive regulation of vasculature development	20/365	175/18862	2.03234848651768e-10	3.56956777799784e-09	1.37188907019968e-09	XBP1/KLF4/CYBB/AKT3/AGO2/SP1/HSPB1/GATA4/ETS1/BRCA1/HMGB1/CXCR4/PRKCA/KDR/GHRL/TERT/SERPINE1/VEGFA/C3/IL10	20
BP	GO:0061684	chaperone-mediated autophagy	8/365	16/18862	2.04822669080578e-10	3.58542424738376e-09	1.37798317413478e-09	STUB1/EEF1A1/ATP13A2/HSP90AA1/SNCA/LAMP2/CLU/GFAP	8
BP	GO:0042098	T cell proliferation	21/365	195/18862	2.1803427278434e-10	3.80397127917746e-09	1.46197717645921e-09	CCL5/GNRH1/PTPRC/CD4/RPS6/CEBPB/IL18/PIK3CG/HMGB1/CTLA4/AGER/VCAM1/LEP/IL6/BMP4/BAX/HLA-DRB1/IGF1/CD40LG/SHH/IL10	21
BP	GO:0050708	regulation of protein secretion	25/365	279/18862	2.1921631711319e-10	3.81188772016757e-09	1.46501969576257e-09	CCL5/ARNTL/CLOCK/ATP13A2/TARDBP/GJA1/CFTR/EGFR/UCP2/SLC2A1/PLA2G6/LEP/APOE/PRKCA/IL6/ITPR1/TLR2/GHRL/ACSL4/DRD4/HLA-DRB1/IFNG/IGF1/CNR1/NOS2	25
BP	GO:0042119	neutrophil activation	34/365	500/18862	2.25688011605115e-10	3.91142732695753e-09	1.50327567158374e-09	MMP9/CYBB/CCL5/PTPRC/MIF/EEF1A1/DNAJC3/DNAJC5/HSP90AA1/HSP90AB1/MAN2B1/DYNC1H1/HUWE1/MAPK1/IL18/CD14/LAMP2/HMGB1/SERPINA1/CST3/B2M/HBB/SERPINA3/HSPA1B/CTSD/HSPA1A/TLR2/TTR/CTSB/ADAM10/MME/C3/HP/MPO	34
BP	GO:0050863	regulation of T cell activation	27/365	327/18862	2.59673365402165e-10	4.48557885978525e-09	1.72393886150265e-09	XBP1/CCL5/GNRH1/PTPRC/CD4/CEBPB/GLI3/IL18/SRC/HMGB1/CTLA4/AGER/VCAM1/LEP/IL6/BMP4/CCL2/HLA-DRB1/NLRP3/IFNG/IGF1/TNFSF11/SOCS1/CAV1/CD40LG/SHH/IL10	27
BP	GO:1904951	positive regulation of establishment of protein localization	27/365	328/18862	2.78034900327217e-10	4.78695614576531e-09	1.83976694780233e-09	PIK3R2/BCL2/HRAS/PINK1/GLI3/ATP13A2/CLN3/HSP90AB1/GSK3B/TARDBP/HUWE1/SORL1/GJA1/MAPK1/SRC/CFTR/EGFR/PLA2G6/LEP/ANK3/TLR2/GHRL/ACSL4/HLA-DRB1/IFNG/IGF1/SHH	27
BP	GO:0010743	regulation of macrophage derived foam cell differentiation	10/365	32/18862	2.87680159745335e-10	4.93678018395765e-09	1.89734869809607e-09	NFKBIA/IL18/PPARA/PPARG/AGTR1/CETP/ABCA1/LPL/AGT/ADIPOQ	10
BP	GO:0010623	programmed cell death involved in cell development	7/365	11/18862	2.96280743166936e-10	5.06775624096649e-09	1.94768661916758e-09	BCL2/PRKDC/KITLG/FASLG/KIT/BAX/NTRK1	7
BP	GO:0050680	negative regulation of epithelial cell proliferation	19/365	160/18862	2.99628834606053e-10	5.10833003364197e-09	1.96328031178525e-09	MEF2C/NUPR1/NF1/GJA1/PPARG/SOX2/APOE/B2M/BRCA2/AR/FGFR2/STAT1/BMP4/NGFR/CCL2/GHRL/PRL/CAV1/XDH	19
BP	GO:0010332	response to gamma radiation	12/365	53/18862	3.0105684203676e-10	5.11601140006625e-09	1.96623248507262e-09	PTPRC/BCL2/HRAS/PARP1/PRKDC/ATM/CDKN1A/BRCA2/BAX/MYC/NOX4/EGR1	12
BP	GO:0032355	response to estradiol	17/365	125/18862	3.08711720775518e-10	5.22911697909081e-09	2.00970225992851e-09	CD4/STXBP1/DNMT3A/CTNNB1/GJA1/ETS1/BCL2L11/EGFR/CCND1/LEP/TXNIP/PDGFRB/CYP19A1/ESR2/IL10/SLC6A4/NQO1	17
BP	GO:0007548	sex differentiation	24/365	262/18862	3.23714489902526e-10	5.46555367790264e-09	2.10057178337428e-09	LRP2/GNRH1/BCL2/NUPR1/CEBPB/ICAM1/GATA4/ATM/CHD7/SRC/BCL2L11/CCND1/LEP/BRCA2/KITLG/AR/KIT/BAX/PDGFRB/CYP19A1/VEGFA/NTRK1/CYP17A1/SHH	24
BP	GO:0009408	response to heat	19/365	161/18862	3.33793853023609e-10	5.61761101841019e-09	2.15901185692373e-09	STUB1/EP300/MTOR/HSP90AA1/HSP90AB1/GSK3B/CREBBP/MAPK1/ATM/CD14/MAPK3/CDKN1A/CXCL12/HSPA1B/HSPA1A/IGF1/CAMK2A/TRPV4/NOS1	19
BP	GO:0010952	positive regulation of peptidase activity	21/365	200/18862	3.49755069057838e-10	5.86736548541258e-09	2.25499978734659e-09	PINK1/SNCA/NGF/PPARG/BCL2L11/HMGB1/AGER/FAS/FASLG/GRIN1/CTSD/NGFR/BAX/APP/NLRP3/MYC/GRIN2B/CAV1/FN1/XDH/GRIN2A	21
BP	GO:0045444	fat cell differentiation	22/365	221/18862	3.70259466365769e-10	6.19149535769469e-09	2.37957235656629e-09	XBP1/KLF4/SORT1/ARNTL/BSCL2/EP300/CEBPB/MTOR/RORA/PPARG/DDIT3/CCND1/ADRB2/LEP/IL6/LPL/SLC2A4/SOCS1/ADIPOQ/HTR2C/NR4A1/BMP2	22
BP	GO:1904892	regulation of receptor signaling pathway via STAT	16/365	110/18862	3.73116019309994e-10	6.21939250021818e-09	2.39029404257928e-09	CCL5/PTPRC/GADD45A/LEP/IL6/NOTCH1/KIT/PRL/IFNG/AGT/SOCS1/GHR/CAV1/IL24/IL10/ERBB4	16
BP	GO:0050806	positive regulation of synaptic transmission	18/365	144/18862	3.79443970360784e-10	6.3006541295944e-09	2.42152525826175e-09	STXBP1/PINK1/MECP2/GSK3B/MAPK1/EGFR/AGER/APOE/NLGN3/CCL2/APP/CNR1/NTRK1/GRIN2B/MME/GRIN2A/NRXN1/RELN	18
BP	GO:0043525	positive regulation of neuron apoptotic process	12/365	54/18862	3.80398682642689e-10	6.3006541295944e-09	2.42152525826175e-09	NUPR1/CTNNB1/NF1/ATF4/HDAC4/ATM/BCL2L11/DDIT3/FASLG/JUN/BAX/NQO1	12
BP	GO:0001558	regulation of cell growth	30/365	406/18862	3.82226752944548e-10	6.31096159278159e-09	2.42548671717427e-09	SPP1/L1CAM/EDN1/BCL2/NEDD4L/RPS6KA3/MTOR/GSK3B/RTN4/MFSD2A/GJA1/PPARA/NGF/PPARG/AGTR1/CDKL5/EGFR/CXCR4/APOE/CDKN1A/CXCL12/HSPA1B/HSPA1A/IGF1/AGT/VEGFA/ADAM10/ESR2/FN1/CDKN2A	30
BP	GO:0010631	epithelial cell migration	28/365	357/18862	3.90952610486476e-10	6.43473573360446e-09	2.47305673167712e-09	MMP9/KLF4/EDN1/AKT3/MEF2C/ZEB2/NF1/MTOR/MECP2/SP1/RTN4/HSPB1/GADD45A/PPARG/ETS1/SRC/PIK3CG/HMGB1/APOE/PRKCA/KDR/NOTCH1/BMP4/KIT/IFNG/AGT/VEGFA/NR4A1	28
BP	GO:0035296	regulation of tube diameter	17/365	127/18862	3.97780897057779e-10	6.5062037975013e-09	2.5005239943336e-09	NPPA/EDNRB/EDN1/GJA1/ICAM1/AGTR1/EGFR/ADRB2/LEP/APOE/AGT/SOD2/CHRM3/CAV1/NOS1/SLC6A4/DBH	17
BP	GO:0097746	blood vessel diameter maintenance	17/365	127/18862	3.97780897057779e-10	6.5062037975013e-09	2.5005239943336e-09	NPPA/EDNRB/EDN1/GJA1/ICAM1/AGTR1/EGFR/ADRB2/LEP/APOE/AGT/SOD2/CHRM3/CAV1/NOS1/SLC6A4/DBH	17
BP	GO:0042326	negative regulation of phosphorylation	30/365	407/18862	4.05462889478616e-10	6.61119240975414e-09	2.54087418197618e-09	NPPA/OCLN/PTPRC/IGF1R/NUPR1/DNAJC3/PRKDC/NF1/MTOR/TARDBP/HDAC4/SORL1/HSPB1/GADD45A/SNCA/PPARA/LRRK2/APOE/CDKN1A/DNAJC10/BMP4/BAX/IFNG/AGT/SOCS1/ADIPOQ/CAV1/XDH/CDKN2A/UCHL1	30
BP	GO:0046660	female sex differentiation	16/365	111/18862	4.28370812598647e-10	6.94146387969449e-09	2.66780714641035e-09	LRP2/GNRH1/BCL2/NUPR1/CEBPB/ICAM1/ATM/CHD7/SRC/LEP/BRCA2/KITLG/KIT/BAX/CYP19A1/VEGFA	16
BP	GO:1905954	positive regulation of lipid localization	16/365	111/18862	4.28370812598647e-10	6.94146387969449e-09	2.66780714641035e-09	SPP1/EDN1/STXBP1/NFKBIA/CETP/APOE/ABCA1/FASLG/GHRL/LPL/CYP19A1/TNFSF11/PLA2G4A/ADIPOQ/CAV1/C3	16
BP	GO:0035150	regulation of tube size	17/365	128/18862	4.50711850657841e-10	7.28094390846648e-09	2.79827922874313e-09	NPPA/EDNRB/EDN1/GJA1/ICAM1/AGTR1/EGFR/ADRB2/LEP/APOE/AGT/SOD2/CHRM3/CAV1/NOS1/SLC6A4/DBH	17
BP	GO:0140353	lipid export from cell	14/365	81/18862	4.54517257245714e-10	7.29737216081002e-09	2.80459308555557e-09	SPP1/EDN1/STXBP1/GJA1/AGTR1/LEP/GHRL/AGT/CYP19A1/TNFSF11/PLA2G4A/POMC/CRHR1/NOS2	14
BP	GO:1905897	regulation of response to endoplasmic reticulum stress	14/365	81/18862	4.54517257245714e-10	7.29737216081002e-09	2.80459308555557e-09	XBP1/NUPR1/ATF6/DNAJC3/MANF/BCL2L11/UBQLN2/DDIT3/LRRK2/PPP1R15A/HSPA1A/BAX/CLU/CAV1	14
BP	GO:0090132	epithelium migration	28/365	360/18862	4.73180478122152e-10	7.573781720157e-09	2.91082534586007e-09	MMP9/KLF4/EDN1/AKT3/MEF2C/ZEB2/NF1/MTOR/MECP2/SP1/RTN4/HSPB1/GADD45A/PPARG/ETS1/SRC/PIK3CG/HMGB1/APOE/PRKCA/KDR/NOTCH1/BMP4/KIT/IFNG/AGT/VEGFA/NR4A1	28
BP	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	12/365	55/18862	4.78167195413912e-10	7.63026555120859e-09	2.93253373053911e-09	KLF4/EDN1/MTOR/HSP90AA1/HSP90AB1/HDAC4/ICAM1/HBB/GRIN1/IFNG/CLU/SOD2	12
BP	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	11/365	44/18862	5.31077360251915e-10	8.44881125701679e-09	3.24712473345516e-09	CCL5/LEP/IL6/NOTCH1/KIT/PRL/AGT/SOCS1/GHR/IL10/ERBB4	11
BP	GO:0002065	columnar/cuboidal epithelial cell differentiation	14/365	82/18862	5.38590321406814e-10	8.54236891588869e-09	3.28308167211618e-09	ARNTL/CLOCK/CEBPB/GSK3B/GATA4/SRC/CDKN1A/NOTCH1/FGFR2/BMP4/SERPINE1/CDH2/BMP2/NPY	14
BP	GO:0035265	organ growth	19/365	166/18862	5.65805148721607e-10	8.94690075048004e-09	3.43855506187626e-09	EDN1/BCL2/MEF2C/MTOR/GJA1/MAPK1/GATA4/PPARA/BCL2L11/LEP/NOTCH1/AR/FGFR2/LEPR/IGF1/PDGFRB/SHH/SLC6A4/ERBB4	19
BP	GO:0007612	learning	17/365	130/18862	5.76596645807232e-10	9.0900808558887e-09	3.49358335490685e-09	HTT/CLN3/NF1/MTOR/MECP2/BCHE/FOS/NLGN3/JUN/GRIN1/KIT/TLR2/APP/SLC6A1/GRIN2A/NRXN1/DBH	17
BP	GO:0070555	response to interleukin-1	21/365	206/18862	6.04942537076751e-10	9.50831603321237e-09	3.65432333919289e-09	CCL5/EDN1/RPS27A/NFKBIA/IKBKG/CEBPB/RORA/HDAC4/ICAM1/SNCA/MAPK3/ETS1/SRC/IL1R1/MTHFR/PRKCA/IL1RN/IL6/CCL2/APP/EGR1	21
BP	GO:0001763	morphogenesis of a branching structure	20/365	186/18862	6.07393262039897e-10	9.51825249555934e-09	3.65814221165535e-09	EDN1/BCL2/DAG1/CTNNB1/GLI3/RTN4/SRC/LRRK2/KDR/NOTCH1/AR/FGFR2/BMP4/MYC/AGT/GDNF/VEGFA/BMP2/SHH/IL10	20
BP	GO:0010632	regulation of epithelial cell migration	25/365	293/18862	6.15374113530154e-10	9.61453167228903e-09	3.69514510905302e-09	MMP9/KLF4/EDN1/AKT3/MEF2C/NF1/MTOR/MECP2/SP1/RTN4/HSPB1/GADD45A/PPARG/ETS1/SRC/PIK3CG/HMGB1/APOE/PRKCA/KDR/NOTCH1/BMP4/IFNG/AGT/VEGFA	25
BP	GO:1904705	regulation of vascular associated smooth muscle cell proliferation	14/365	83/18862	6.36635856244095e-10	9.88769160706705e-09	3.80012844379968e-09	MMP9/EDN1/MEF2C/GJA1/PPARG/DNMT1/CDKN1A/JUN/TERT/MMP2/IGF1/SOD2/ADIPOQ/IL10	14
BP	GO:1990874	vascular associated smooth muscle cell proliferation	14/365	83/18862	6.36635856244095e-10	9.88769160706705e-09	3.80012844379968e-09	MMP9/EDN1/MEF2C/GJA1/PPARG/DNMT1/CDKN1A/JUN/TERT/MMP2/IGF1/SOD2/ADIPOQ/IL10	14
BP	GO:0090130	tissue migration	28/365	365/18862	6.47401631857342e-10	1.0025148346572e-08	3.85295708028459e-09	MMP9/KLF4/EDN1/AKT3/MEF2C/ZEB2/NF1/MTOR/MECP2/SP1/RTN4/HSPB1/GADD45A/PPARG/ETS1/SRC/PIK3CG/HMGB1/APOE/PRKCA/KDR/NOTCH1/BMP4/KIT/IFNG/AGT/VEGFA/NR4A1	28
BP	GO:0007162	negative regulation of cell adhesion	25/365	295/18862	7.09424045989695e-10	1.09531724386728e-08	4.2096238220348e-09	KLF4/GNRH1/PTPRC/CEBPB/GLI3/PPARA/SRC/HMGB1/CTLA4/IL1RN/NOTCH1/CXCL12/EPCAM/BMP4/HLA-DRB1/SERPINE1/SOCS1/ADIPOQ/VEGFA/ADAM10/TRPV4/CDKN2A/BMP2/SHH/IL10	25
BP	GO:0042593	glucose homeostasis	22/365	229/18862	7.31182519059456e-10	1.12559097198741e-08	4.32597459418768e-09	XBP1/PIK3R2/IGF1R/RPS6/ICAM1/GATA4/PPARG/CFTR/UCP2/AGER/PLA2G6/LEP/IL6/NGFR/GHRL/LEPR/HLA-DRB1/SLC2A4/ADIPOQ/CNR1/POMC/DBH	22
BP	GO:0010469	regulation of signaling receptor activity	20/365	188/18862	7.34772608916991e-10	1.12780053814414e-08	4.33446660176067e-09	EDN1/MEF2C/PINK1/PPARA/PPARG/SRC/ADRB2/NLGN3/GRIN1/CCL2/APP/IFNG/SERPINE1/GRIN2B/GRIA1/ESR2/CALCR/GRIN2A/RELN/IL10	20
BP	GO:0009416	response to light stimulus	26/365	319/18862	7.44088514003882e-10	1.1354400239931e-08	4.36382737536111e-09	MMP9/TRPM1/BCL2/PARP1/EP300/CLOCK/NF1/MTOR/MECP2/ATF4/CREBBP/EGFR/FOS/CCND1/CDKN1A/BRCA2/GRIN1/MMP3/KIT/BAX/APP/MMP2/MYC/MME/GRIN2A/DBH	26
BP	GO:0043271	negative regulation of ion transport	26/365	319/18862	7.44088514003882e-10	1.1354400239931e-08	4.36382737536111e-09	MMP9/BCL2/NEDD4L/ATP7A/TXN/MTOR/ATF4/UBE2J1/ICAM1/SNCA/UCP2/LEP/LRRK2/APOE/ANK3/GHRL/DRD4/CASQ2/ADIPOQ/CNR1/CRHR1/CAV1/KCNH2/P2RY12/NOS1/SHH	26
BP	GO:0014031	mesenchymal cell development	14/365	84/18862	7.50716933607455e-10	1.14222454375041e-08	4.38990226476085e-09	EDNRB/EDN1/BCL2/MAPK1/MAPK3/NRG1/NOTCH1/KITLG/BMP4/GDNF/CDH2/FN1/SHH/ERBB4	14
BP	GO:0033500	carbohydrate homeostasis	22/365	230/18862	7.94406634518972e-10	1.20377153977648e-08	4.62644533216590e-09	XBP1/PIK3R2/IGF1R/RPS6/ICAM1/GATA4/PPARG/CFTR/UCP2/AGER/PLA2G6/LEP/IL6/NGFR/GHRL/LEPR/HLA-DRB1/SLC2A4/ADIPOQ/CNR1/POMC/DBH	22
BP	GO:0034612	response to tumor necrosis factor	26/365	320/18862	7.95767964773904e-10	1.20377153977648e-08	4.62644533216590e-09	CCL5/OCLN/EDN1/NFKBIA/IKBKG/RORA/TNFRSF1A/HDAC4/ICAM1/MAPK1/CD14/MAPK3/CASP4/BRCA1/VCAM1/FAS/STAT1/HSPA1B/CCL2/HSPA1A/KRT8/SLC2A4/TNFSF11/ADIPOQ/ADAM10/CD40LG	26
BP	GO:0031346	positive regulation of cell projection organization	27/365	344/18862	8.00246423322475e-10	1.20705757339188e-08	4.63907451833536e-09	L1CAM/OCLN/HRAS/EP300/HTT/ATP7A/SCARB2/MTOR/CUX1/SETX/P2RX7/HDAC4/NGF/SRC/CDKL5/APOE/CXCL12/NGFR/KIT/IL1RAPL1/SERPINI1/CNR1/VEGFA/NTRK1/FN1/P2RY12/RELN	27
BP	GO:0022408	negative regulation of cell-cell adhesion	20/365	189/18862	8.07388829798512e-10	1.21433136067972e-08	4.66702980564113e-09	KLF4/GNRH1/CEBPB/GLI3/PPARA/HMGB1/CTLA4/IL1RN/NOTCH1/CXCL12/EPCAM/BMP4/HLA-DRB1/SOCS1/ADIPOQ/VEGFA/TRPV4/BMP2/SHH/IL10	20
BP	GO:0002687	positive regulation of leukocyte migration	17/365	133/18862	8.27206900646942e-10	1.24057332893584e-08	4.76788534802083e-09	CCL5/EDN1/ICAM1/MAPK1/MAPK3/IL1R1/HMGB1/AGER/IL6/KITLG/CXCL12/THBS4/APP/SERPINE1/VEGFA/ADAM10/P2RY12	17
BP	GO:0060079	excitatory postsynaptic potential	15/365	100/18862	8.55812344409958e-10	1.27874364532709e-08	4.91458501341446e-09	MEF2C/MECP2/GSK3B/P2RX7/ADRB2/DMPK/LRRK2/NLGN3/GRIN1/GHRL/APP/GRIN2B/GRIN2A/NRXN1/RELN	15
BP	GO:0002446	neutrophil mediated immunity	33/365	499/18862	8.57544936014155e-10	1.27874364532709e-08	4.91458501341446e-09	MMP9/CYBB/PTPRC/MIF/EEF1A1/DNAJC3/DNAJC5/HSP90AA1/HSP90AB1/MAN2B1/DYNC1H1/HUWE1/MAPK1/CD14/LAMP2/HMGB1/SERPINA1/CST3/B2M/IL6/HBB/SERPINA3/HSPA1B/CTSD/HSPA1A/TLR2/TTR/CTSB/ADAM10/MME/C3/HP/MPO	33
BP	GO:0032370	positive regulation of lipid transport	14/365	85/18862	8.83163240310586e-10	1.31320352266637e-08	5.04702437868878e-09	SPP1/EDN1/STXBP1/NFKBIA/CETP/APOE/ABCA1/FASLG/GHRL/CYP19A1/TNFSF11/PLA2G4A/ADIPOQ/CAV1	14
BP	GO:0045861	negative regulation of proteolysis	27/365	346/18862	9.09129354833574e-10	1.34798386492887e-08	5.18069538418655e-09	MMP9/KLF4/PLAT/RPS6KA3/RPL5/CLN3/XIAP/HSP90AB1/SORL1/SNCA/NGF/SRC/SERPINA1/FURIN/CST3/LRRK2/SERPINA3/C4A/NGFR/APP/SERPINI1/SERPINE1/AGT/VEGFA/C3/SHH/IL10	27
BP	GO:0014812	muscle cell migration	15/365	101/18862	9.87622278135218e-10	1.46023022705077e-08	5.61209091143741e-09	CCL5/PLAT/BCL2/MEF2C/ATP7A/HDAC4/SORL1/SRC/THBS4/TERT/IGF1/SERPINE1/PDGFRB/ADIPOQ/NOX4	15
BP	GO:0008406	gonad development	21/365	212/18862	1.02586163120432e-09	1.51249571203477e-08	5.81296242322153e-09	LRP2/GNRH1/BCL2/NUPR1/CEBPB/ICAM1/GATA4/ATM/SRC/BCL2L11/CCND1/LEP/BRCA2/KITLG/AR/KIT/BAX/PDGFRB/CYP19A1/VEGFA/NTRK1	21
BP	GO:0031330	negative regulation of cellular catabolic process	23/365	255/18862	1.03449221954625e-09	1.52093603289468e-08	5.8454010394822e-09	BCL2/NUPR1/PINK1/RPL5/ATP13A2/MTOR/HSP90AB1/TARDBP/MFSD2A/SORL1/SNCA/GATA4/PIK3CG/LEP/FURIN/CST3/LRRK2/LEPR/GDNF/CNR1/HP/SHH/IL10	23
BP	GO:0060048	cardiac muscle contraction	17/365	135/18862	1.04646037381185e-09	1.53422229594712e-08	5.8964640258129e-09	NPPA/NEDD4L/ATP1A1/MTOR/HDAC4/GJA1/GATA4/ANK2/PIK3CG/CXCR4/KCNQ1/RYR2/CASQ2/CAV1/KCNH2/SCN5A/NOS1	17
BP	GO:2000310	regulation of NMDA receptor activity	10/365	36/18862	1.05802634883147e-09	1.54684634351506e-08	5.94498192477783e-09	MEF2C/PINK1/GRIN1/CCL2/APP/IFNG/GRIN2B/GRIA1/GRIN2A/RELN	10
BP	GO:0051101	regulation of DNA binding	16/365	118/18862	1.08158496976267e-09	1.57688460494089e-08	6.06042772970666e-09	MMP9/KLF4/NFKBIA/PARP1/CTNNB1/NSD1/EP300/TXN/NGF/PPARG/DDIT3/HMGB1/AGER/JUN/IFNG/IGF1	16
BP	GO:0042116	macrophage activation	15/365	102/18862	1.13778829364145e-09	1.64963543737378e-08	6.34003041011461e-09	PTPRC/MIF/RORA/SNCA/ATM/HMGB1/AGER/LRRK2/IL6/TLR2/APP/IFNG/CLU/PLA2G4A/IL10	15
BP	GO:0045639	positive regulation of myeloid cell differentiation	15/365	102/18862	1.13778829364145e-09	1.64963543737378e-08	6.34003041011461e-09	CD4/PRKDC/ETS1/HMGB1/FOS/PRKCA/KITLG/JUN/STAT1/HSPA1B/HSPA1A/CSF3/HLA-DRB1/IFNG/TNFSF11	15
BP	GO:0030225	macrophage differentiation	11/365	47/18862	1.14502417217864e-09	1.65554047435995e-08	6.36272519055942e-09	MMP9/CD4/PARP1/PRKCA/BMP4/TLR2/APP/HLA-DRB1/IFNG/ADIPOQ/VEGFA	11
BP	GO:0060348	bone development	20/365	193/18862	1.16984314834355e-09	1.68676557532511e-08	6.48273236620133e-09	COL2A1/PTPRC/MEF2C/EP300/GLI3/GJA1/SRC/LEP/PPIB/FGFR2/DLX5/BGLAP/BMP4/KIT/GHRL/IGF1/TNFSF11/FBN1/TRPV4/BMP2	20
BP	GO:0036294	cellular response to decreased oxygen levels	21/365	214/18862	1.21823110303225e-09	1.75170922892055e-08	6.73232977991507e-09	CYBB/EDN1/RPS27A/BCL2/DNMT3A/PINK1/STUB1/EP300/ATP7A/MTOR/ATF4/CREBBP/RORA/ICAM1/SRC/NOTCH1/TERT/MYC/SLC2A4/VEGFA/EGR1	21
BP	GO:0001101	response to acid chemical	16/365	119/18862	1.22785905250868e-09	1.7607162413234e-08	6.76694635715669e-09	XBP1/CYBB/EDN1/DNMT3A/ATP7A/CEBPB/MTOR/ICAM1/MTHFR/GRIN1/MMP2/KRT8/SOCS1/VEGFA/NTRK1/NQO1	16
BP	GO:0031644	regulation of nervous system process	17/365	137/18862	1.31823419440156e-09	1.88514693264967e-08	7.24516981737528e-09	EDNRB/EDN1/DAG1/MTOR/SRC/DICER1/ADRB2/DMPK/LRRK2/NLGN3/GRIN1/GHRL/APP/HTR2C/NRXN1/RELN/IL10	17
BP	GO:0040014	regulation of multicellular organism growth	12/365	60/18862	1.39814487909524e-09	1.99397555781594e-08	7.66342998408435e-09	BCL2/RAI1/MFSD2A/CHD7/ADRB2/PPIB/GHRL/APP/PRL/IGF1/GHR/GDF15	12
BP	GO:0014909	smooth muscle cell migration	14/365	88/18862	1.41862898465626e-09	2.01769133306817e-08	7.75457662951405e-09	CCL5/PLAT/BCL2/MEF2C/ATP7A/HDAC4/SORL1/SRC/TERT/IGF1/SERPINE1/PDGFRB/ADIPOQ/NOX4	14
BP	GO:1904894	positive regulation of receptor signaling pathway via STAT	11/365	48/18862	1.45993940911235e-09	2.07081920522874e-08	7.95876254689404e-09	CCL5/LEP/IL6/NOTCH1/KIT/PRL/AGT/SOCS1/GHR/IL10/ERBB4	11
BP	GO:0048167	regulation of synaptic plasticity	19/365	176/18862	1.53585031231153e-09	2.17260554990232e-08	8.34995717447323e-09	STXBP1/HRAS/MEF2C/CLN3/MECP2/ATF4/GSK3B/MAPK1/AGER/APOE/GRIN1/KIT/APP/GRIN2B/CAMK2A/MME/GRIA1/GRIN2A/RELN	19
BP	GO:0045137	development of primary sexual characteristics	21/365	217/18862	1.57053743990692e-09	2.21568543408971e-08	8.51552574169989e-09	LRP2/GNRH1/BCL2/NUPR1/CEBPB/ICAM1/GATA4/ATM/SRC/BCL2L11/CCND1/LEP/BRCA2/KITLG/AR/KIT/BAX/PDGFRB/CYP19A1/VEGFA/NTRK1	21
BP	GO:0051403	stress-activated MAPK cascade	23/365	261/18862	1.62806927519376e-09	2.29067596407638e-08	8.80373623343315e-09	NPPA/RPS27A/IGF1R/IKBKG/EIF2AK2/HRAS/PINK1/MAPK1/GADD45A/MAPK3/EGFR/HMGB1/AGER/LEP/FAS/TF/APP/MYC/TNFSF11/VEGFA/XDH/CD40LG/BMP2	23
BP	GO:0050921	positive regulation of chemotaxis	17/365	139/18862	1.65378999508276e-09	2.31240630779137e-08	8.88725228604331e-09	CCL5/EDN1/HSPB1/MAPK1/MAPK3/HMGB1/AGER/CXCR4/KDR/IL6/CXCL12/THBS4/SERPINE1/PDGFRB/VEGFA/ADAM10/P2RY12	17
BP	GO:0046849	bone remodeling	14/365	89/18862	1.65425737301739e-09	2.31240630779137e-08	8.88725228604331e-09	SPP1/NF1/P2RX7/GJA1/SRC/EGFR/ADRB2/LEP/TF/PRKCA/IL6/BGLAP/LEPR/TNFSF11	14
BP	GO:0043312	neutrophil degranulation	32/365	485/18862	1.65676798896019e-09	2.31240630779137e-08	8.88725228604331e-09	MMP9/CYBB/PTPRC/MIF/EEF1A1/DNAJC3/DNAJC5/HSP90AA1/HSP90AB1/MAN2B1/DYNC1H1/HUWE1/MAPK1/CD14/LAMP2/HMGB1/SERPINA1/CST3/B2M/HBB/SERPINA3/HSPA1B/CTSD/HSPA1A/TLR2/TTR/CTSB/ADAM10/MME/C3/HP/MPO	32
BP	GO:0034341	response to interferon-gamma	20/365	197/18862	1.6789295376143e-09	2.33710563826416e-08	8.98217902122318e-09	CCL5/EDN1/STXBP1/HSP90AB1/ICAM1/SNCA/PPARG/VCAM1/HLA-DQA1/B2M/FASLG/STAT1/CCL2/TLR2/HLA-DRB1/IFNG/SOCS1/CAMK2A/NOS2/HLA-DQB1	20
BP	GO:0001959	regulation of cytokine-mediated signaling pathway	19/365	177/18862	1.6905312255019e-09	2.34080434769231e-08	8.996394240975e-09	CCL5/PTPRC/EDN1/IKBKG/HSP90AB1/TNFRSF1A/CASP4/PPARG/IL1R1/CXCR4/IL1RN/IL6/STAT1/HSPA1B/HSPA1A/IFNG/SOCS1/ADIPOQ/CAV1	19
BP	GO:0071346	cellular response to interferon-gamma	19/365	177/18862	1.6905312255019e-09	2.34080434769231e-08	8.996394240975e-09	CCL5/EDN1/STXBP1/HSP90AB1/ICAM1/PPARG/VCAM1/HLA-DQA1/B2M/FASLG/STAT1/CCL2/TLR2/HLA-DRB1/IFNG/SOCS1/CAMK2A/NOS2/HLA-DQB1	19
BP	GO:0046686	response to cadmium ion	12/365	61/18862	1.71054914998909e-09	2.35605638185339e-08	9.0550122593605e-09	MMP9/CYBB/ATP7A/MAPK1/MAPK3/EGFR/FOS/B2M/JUN/KIT/TERT/SOD2	12
BP	GO:0048645	animal organ formation	12/365	61/18862	1.71054914998909e-09	2.35605638185339e-08	9.0550122593605e-09	LRP2/MEF2C/GLI3/MAPK1/MAPK3/NOTCH1/AR/FGFR2/BMP4/GDNF/BMP2/SHH	12
BP	GO:0051054	positive regulation of DNA metabolic process	20/365	198/18862	1.83498530452029e-09	2.52081708237775e-08	9.68823571470723e-09	KLF4/PTPRC/PARP1/USP9X/PRKDC/MECP2/HSP90AA1/HSP90AB1/HNRNPA1/MAPK1/ATM/MAPK3/SRC/BRCA1/EGFR/HMGB1/IL6/BAX/PDGFRB/MYC	20
BP	GO:0050796	regulation of insulin secretion	19/365	178/18862	1.85953461612688e-09	2.54785449759375e-08	9.7921483918944e-09	CCL5/ARNTL/CLOCK/TARDBP/GJA1/CFTR/UCP2/SLC2A1/PLA2G6/LEP/PRKCA/IL6/ITPR1/GHRL/ACSL4/HLA-DRB1/IFNG/CNR1/NOS2	19
BP	GO:0002283	neutrophil activation involved in immune response	32/365	488/18862	1.9273516009571e-09	2.63387944632101e-08	1.01227673750969e-08	MMP9/CYBB/PTPRC/MIF/EEF1A1/DNAJC3/DNAJC5/HSP90AA1/HSP90AB1/MAN2B1/DYNC1H1/HUWE1/MAPK1/CD14/LAMP2/HMGB1/SERPINA1/CST3/B2M/HBB/SERPINA3/HSPA1B/CTSD/HSPA1A/TLR2/TTR/CTSB/ADAM10/MME/C3/HP/MPO	32
BP	GO:0051100	negative regulation of binding	18/365	159/18862	1.9338416006579e-09	2.6358663900634e-08	1.01304037797622e-08	NFKBIA/STUB1/GSK3B/CYP2D6/SORL1/PPARA/MAPK3/DDIT3/ADRB2/LRRK2/B2M/CDKN1A/JUN/BAX/AURKA/ADIPOQ/CAV1/IL10	18
BP	GO:2001242	regulation of intrinsic apoptotic signaling pathway	18/365	160/18862	2.14099533156591e-09	2.91064144556258e-08	1.11864445075118e-08	XBP1/MMP9/MIF/BCL2/NUPR1/PARP1/PINK1/HSPB1/SRC/BCL2L11/DDIT3/LRRK2/CXCL12/HSPA1A/BAX/CLU/SOD2/CAV1	18
BP	GO:0048568	embryonic organ development	29/365	412/18862	2.31919121235546e-09	3.14472715167577e-08	1.20861041909225e-08	COL2A1/EDN1/MEF2C/CTNNB1/CEBPB/GLI3/MED12/ATF4/KMT2A/MAPK1/GATA4/MAPK3/CHD7/KDR/NOTCH1/KITLG/FGFR2/DLX5/BMP4/KIT/SATB2/KRT8/RYR2/GDNF/VEGFA/FBN1/FOXG1/SHH/IL10	29
BP	GO:0006937	regulation of muscle contraction	18/365	161/18862	2.36847523795582e-09	3.2032556577418e-08	1.23110463205048e-08	NPPA/EDN1/ATP1A1/HDAC4/GATA4/ANK2/PIK3CG/ADRB2/DMPK/KIT/KCNQ1/GHRL/RYR2/CASQ2/CHRM3/CAV1/SCN5A/NOS1	18
BP	GO:0001933	negative regulation of protein phosphorylation	27/365	362/18862	2.43772074086935e-09	3.28840988600778e-08	1.26383188708663e-08	NPPA/OCLN/PTPRC/IGF1R/DNAJC3/PRKDC/NF1/MTOR/TARDBP/SORL1/HSPB1/GADD45A/SNCA/LRRK2/APOE/CDKN1A/DNAJC10/BMP4/BAX/IFNG/AGT/SOCS1/ADIPOQ/CAV1/XDH/CDKN2A/UCHL1	27
BP	GO:0032872	regulation of stress-activated MAPK cascade	19/365	181/18862	2.46503155151883e-09	3.3167031209896e-08	1.27470580299079e-08	NPPA/IGF1R/EIF2AK2/HRAS/PINK1/MAPK1/GADD45A/MAPK3/EGFR/HMGB1/AGER/LEP/FAS/APP/MYC/TNFSF11/VEGFA/XDH/BMP2	19
BP	GO:0014015	positive regulation of gliogenesis	12/365	63/18862	2.53062874240746e-09	3.39623354814375e-08	1.30527166713648e-08	LRP2/DAG1/MTOR/PPARG/DICER1/CXCR4/IL6/NOTCH1/TLR2/GJC2/BMP2/SHH	12
BP	GO:0001938	positive regulation of endothelial cell proliferation	15/365	108/18862	2.57128838898491e-09	3.43456846874006e-08	1.3200048958756e-08	AKT3/MTOR/SP1/AGTR1/HMGB1/PRKCA/KDR/CXCL12/BMP4/THBS4/GHRL/VEGFA/NR4A1/BMP2/IL10	15
BP	GO:0048754	branching morphogenesis of an epithelial tube	17/365	143/18862	2.57231723298835e-09	3.43456846874006e-08	1.3200048958756e-08	EDN1/BCL2/DAG1/CTNNB1/GLI3/SRC/KDR/NOTCH1/AR/FGFR2/BMP4/MYC/AGT/GDNF/VEGFA/BMP2/SHH	17
BP	GO:0014074	response to purine-containing compound	17/365	144/18862	2.86585144924559e-09	3.81675991993675e-08	1.46689222432257e-08	NDUFS4/P2RX7/PPARG/PIK3CG/CFTR/FOS/AHR/JUN/STAT1/KCNQ1/APP/RYR2/CASQ2/ADIPOQ/NOX4/P2RY12/SLC6A4	17
BP	GO:0008585	female gonad development	14/365	93/18862	2.99748561676937e-09	3.97185815649896e-08	1.52650100297036e-08	GNRH1/BCL2/NUPR1/CEBPB/ICAM1/ATM/SRC/LEP/BRCA2/KITLG/KIT/BAX/CYP19A1/VEGFA	14
BP	GO:0051153	regulation of striated muscle cell differentiation	14/365	93/18862	2.99748561676937e-09	3.97185815649896e-08	1.52650100297036e-08	XBP1/EDN1/BCL2/MEF2C/MTOR/HDAC4/PPARA/DMPK/NRG1/NOTCH1/BMP4/IGF1/BMP2/SHH	14
BP	GO:0050807	regulation of synapse organization	20/365	204/18862	3.09154220676504e-09	4.08614442176976e-08	1.57042455000744e-08	MEF2C/DAG1/CLN3/SNCA/CDKL5/DMPK/LRRK2/APOE/NLGN3/TLR2/GHRL/APP/IL1RAPL1/CDH2/ADAM10/NTRK1/GRIN2B/NRXN1/RELN/IL10	20
BP	GO:0006631	fatty acid metabolic process	28/365	392/18862	3.20184209975085e-09	4.22126991186297e-08	1.622357219309e-08	XBP1/PLP1/CEL/ABCD1/EDN1/MIF/PTGS1/MTOR/MFSD2A/TNFRSF1A/CYP2D6/CYP2U1/PPARA/CYP2E1/MAPK3/PPARG/BRCA1/LEP/ALDH3A2/GSTM1/ACSL4/LPL/PLA2G4A/ADIPOQ/CNR1/CYP1A1/CAV1/C3	28
BP	GO:0070302	regulation of stress-activated protein kinase signaling cascade	19/365	184/18862	3.24880004210148e-09	4.27241693978874e-08	1.64201451479924e-08	NPPA/IGF1R/EIF2AK2/HRAS/PINK1/MAPK1/GADD45A/MAPK3/EGFR/HMGB1/AGER/LEP/FAS/APP/MYC/TNFSF11/VEGFA/XDH/BMP2	19
BP	GO:0030595	leukocyte chemotaxis	21/365	226/18862	3.27865742304488e-09	4.30087542662077e-08	1.6529519418121e-08	CCR5/EDNRB/CCL5/EDN1/MIF/MAPK1/MAPK3/PIK3CG/HMGB1/CXCR4/IL6/PPIB/CXCL12/CCL2/THBS4/KIT/SERPINE1/TNFSF11/VEGFA/ADAM10/IL10	21
BP	GO:0051341	regulation of oxidoreductase activity	15/365	110/18862	3.33350997287799e-09	4.36189779951084e-08	1.67640462057101e-08	EDN1/ATP7A/HSP90AA1/SNCA/AGTR1/EGFR/LEP/APOE/TERT/IFNG/AGT/GDNF/CNR1/CAV1/HP	15
BP	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	20/365	205/18862	3.36598740075569e-09	4.39341098642276e-08	1.68851605797194e-08	MMP9/KLF4/RPS6KA3/XIAP/SNCA/NGF/PPARG/SRC/BCL2L11/SOX2/HMGB1/FAS/FASLG/CTSD/NGFR/BAX/NLRP3/MYC/VEGFA/XDH	20
BP	GO:0030198	extracellular matrix organization	28/365	393/18862	3.38736851956311e-09	4.41032010731177e-08	1.69501472659992e-08	COL2A1/SPP1/MMP9/DAG1/ATP7A/NF1/TNFRSF1A/ICAM1/ETS1/VCAM1/FURIN/CST3/KDR/IL6/NOTCH1/ELN/MMP3/APP/MMP2/SERPINE1/AGT/TTR/ADAM10/FBN1/CAV1/FN1/COL9A2/BMP2	28
BP	GO:0048872	homeostasis of number of cells	22/365	249/18862	3.53616591278148e-09	4.59262838399461e-08	1.7650811177551e-08	BCL2/AKT3/MEF2C/RPS6/PRKDC/ETS1/BCL2L11/HMGB1/P4HTM/FAS/B2M/IL6/NOTCH1/KITLG/STAT1/HSPA1B/BMP4/KIT/HSPA1A/BAX/CDH2/VEGFA	22
BP	GO:0043062	extracellular structure organization	28/365	394/18862	3.58294632018813e-09	4.64186659402591e-08	1.78400479882218e-08	COL2A1/SPP1/MMP9/DAG1/ATP7A/NF1/TNFRSF1A/ICAM1/ETS1/VCAM1/FURIN/CST3/KDR/IL6/NOTCH1/ELN/MMP3/APP/MMP2/SERPINE1/AGT/TTR/ADAM10/FBN1/CAV1/FN1/COL9A2/BMP2	28
BP	GO:0071456	cellular response to hypoxia	20/365	206/18862	3.66287394523729e-09	4.73369931589431e-08	1.81929879385275e-08	CYBB/EDN1/RPS27A/BCL2/DNMT3A/PINK1/STUB1/EP300/ATP7A/MTOR/CREBBP/RORA/ICAM1/SRC/NOTCH1/TERT/MYC/SLC2A4/VEGFA/EGR1	20
BP	GO:0071356	cellular response to tumor necrosis factor	24/365	296/18862	3.78166349366064e-09	4.87517899650734e-08	1.87367356400972e-08	CCL5/OCLN/EDN1/NFKBIA/IKBKG/RORA/TNFRSF1A/HDAC4/ICAM1/MAPK1/MAPK3/CASP4/BRCA1/VCAM1/FAS/STAT1/HSPA1B/CCL2/HSPA1A/KRT8/SLC2A4/TNFSF11/ADIPOQ/CD40LG	24
BP	GO:0030073	insulin secretion	20/365	207/18862	3.98387736438837e-09	5.11707545583433e-08	1.96664143275736e-08	CCL5/ARNTL/CLOCK/TARDBP/GJA1/CFTR/UCP2/SLC2A1/PLA2G6/LEP/PRKCA/IL1RN/IL6/ITPR1/GHRL/ACSL4/HLA-DRB1/IFNG/CNR1/NOS2	20
BP	GO:0010522	regulation of calcium ion transport into cytosol	14/365	95/18862	3.98885515089875e-09	5.11707545583433e-08	1.96664143275736e-08	CD4/BCL2/HTT/P2RX7/SNCA/ANK2/CHD7/GRIN1/BAX/RYR2/CASQ2/CAV1/CALCR/NOS1	14
BP	GO:0045229	external encapsulating structure organization	28/365	396/18862	4.00630252390397e-09	5.12689178731378e-08	1.97041413542156e-08	COL2A1/SPP1/MMP9/DAG1/ATP7A/NF1/TNFRSF1A/ICAM1/ETS1/VCAM1/FURIN/CST3/KDR/IL6/NOTCH1/ELN/MMP3/APP/MMP2/SERPINE1/AGT/TTR/ADAM10/FBN1/CAV1/FN1/COL9A2/BMP2	28
BP	GO:0048863	stem cell differentiation	22/365	251/18862	4.10279801157033e-09	5.23757190062417e-08	2.01295173301948e-08	EDNRB/PTPRC/EDN1/EIF2AK2/MEF2C/PRKDC/KMT2A/MAPK1/GATA4/MAPK3/NRG1/NOTCH1/KITLG/FGFR2/EPCAM/BMP4/KIT/GDNF/CDH2/FN1/SHH/ERBB4	22
BP	GO:0032411	positive regulation of transporter activity	15/365	112/18862	4.29718558179895e-09	5.4723769671863e-08	2.10319417257467e-08	NPPA/PINK1/HTT/KMT2A/ANK2/CFTR/ADRB2/NLGN3/CCL2/ANK3/DRD4/IFNG/RYR2/ADIPOQ/RELN	15
BP	GO:0035264	multicellular organism growth	16/365	130/18862	4.57216954154145e-09	5.8084309175796e-08	2.23234951300095e-08	BCL2/RAI1/EP300/MTOR/MFSD2A/ATM/CHD7/ADRB2/PPIB/AR/GHRL/APP/PRL/IGF1/GHR/GDF15	16
BP	GO:0032091	negative regulation of protein binding	14/365	96/18862	4.58895195309543e-09	5.81563547760326e-08	2.2351184356736e-08	STUB1/GSK3B/SORL1/PPARA/MAPK3/ADRB2/LRRK2/B2M/CDKN1A/BAX/AURKA/ADIPOQ/CAV1/IL10	14
BP	GO:0060541	respiratory system development	19/365	188/18862	4.6539498018115e-09	5.88376165765251e-08	2.261301314839e-08	HSD11B1/DAG1/EP300/ATP7A/GLI3/EIF4E/MAPK1/MAPK3/CHD7/EGFR/HMGB1/NOTCH1/FGFR2/DLX5/BMP4/PDGFRB/VEGFA/MME/SHH	19
BP	GO:0035967	cellular response to topologically incorrect protein	18/365	168/18862	4.70153047337625e-09	5.9153390619354e-08	2.2734374328497e-08	XBP1/UGGT1/ATF6/STUB1/DNAJC3/EP300/ATF4/VAPB/BCL2L11/DDIT3/ATF3/CCND1/CANX/HSPA1B/CCL2/PPP1R15A/HSPA1A/BAX	18
BP	GO:0042129	regulation of T cell proliferation	18/365	168/18862	4.70153047337625e-09	5.9153390619354e-08	2.2734374328497e-08	CCL5/GNRH1/PTPRC/CD4/CEBPB/IL18/HMGB1/CTLA4/AGER/VCAM1/LEP/IL6/BMP4/HLA-DRB1/IGF1/CD40LG/SHH/IL10	18
BP	GO:0031098	stress-activated protein kinase signaling cascade	23/365	276/18862	4.77945095880143e-09	5.99895595164668e-08	2.30557384381409e-08	NPPA/RPS27A/IGF1R/IKBKG/EIF2AK2/HRAS/PINK1/MAPK1/GADD45A/MAPK3/EGFR/HMGB1/AGER/LEP/FAS/TF/APP/MYC/TNFSF11/VEGFA/XDH/CD40LG/BMP2	23
BP	GO:0034620	cellular response to unfolded protein	17/365	149/18862	4.85294984884364e-09	6.0766362461358e-08	2.33542864798293e-08	XBP1/ATF6/STUB1/DNAJC3/EP300/ATF4/VAPB/BCL2L11/DDIT3/ATF3/CCND1/CANX/HSPA1B/CCL2/PPP1R15A/HSPA1A/BAX	17
BP	GO:0014910	regulation of smooth muscle cell migration	13/365	81/18862	4.94024514931851e-09	6.15648645512692e-08	2.36611741362097e-08	CCL5/BCL2/MEF2C/ATP7A/HDAC4/SORL1/SRC/TERT/IGF1/SERPINE1/PDGFRB/ADIPOQ/NOX4	13
BP	GO:0099601	regulation of neurotransmitter receptor activity	13/365	81/18862	4.94024514931851e-09	6.15648645512692e-08	2.36611741362097e-08	MEF2C/PINK1/SRC/ADRB2/NLGN3/GRIN1/CCL2/APP/IFNG/GRIN2B/GRIA1/GRIN2A/RELN	13
BP	GO:0046545	development of primary female sexual characteristics	14/365	97/18862	5.27005757399877e-09	6.55189580577424e-08	2.51808476657373e-08	GNRH1/BCL2/NUPR1/CEBPB/ICAM1/ATM/SRC/LEP/BRCA2/KITLG/KIT/BAX/CYP19A1/VEGFA	14
BP	GO:0010975	regulation of neuron projection development	29/365	428/18862	5.49300356519442e-09	6.81288641237621e-08	2.61839107335658e-08	SPP1/L1CAM/KLF4/NEDD4L/EP300/SCARB2/MTOR/GSK3B/CUX1/SETX/RTN4/MFSD2A/NGF/CDKL5/LRRK2/APOE/B2M/CXCL12/NGFR/IL1RAPL1/SERPINI1/CDH2/CNR1/VEGFA/ADAM10/NTRK1/TRPV4/FN1/RELN	29
BP	GO:0045664	regulation of neuron differentiation	19/365	190/18862	5.5502184656556e-09	6.86757528350861e-08	2.63940960255515e-08	EDNRB/BCL2/MEF2C/GLI3/MTOR/GSK3B/EIF4E/NGF/SOX2/LRRK2/B2M/NOTCH1/CXCL12/BMP4/APP/FOXG1/BMP2/SHH/SLC6A4	19
BP	GO:0006936	muscle contraction	26/365	352/18862	5.95236154370145e-09	7.34779724522014e-08	2.82397291708378e-08	NPPA/EDNRB/EDN1/NEDD4L/ATP1A1/MTOR/HDAC4/GJA1/GATA4/ANK2/PIK3CG/SLC6A8/ADRB2/DMPK/CXCR4/KIT/KCNQ1/GHRL/RYR2/CASQ2/GDNF/CHRM3/CAV1/KCNH2/SCN5A/NOS1	26
BP	GO:0006898	receptor-mediated endocytosis	25/365	328/18862	6.26381702310548e-09	7.71407489386684e-08	2.96474410678751e-08	HBA1/LRP2/CLN3/SCARB2/HSP90AA1/SORL1/SNCA/CD14/UBQLN2/ADRB2/TF/APOE/B2M/CANX/HBB/NLGN3/DRD4/SERPINE1/CLU/ADIPOQ/VEGFA/GRIA1/CAV1/C3/HP	25
BP	GO:0051052	regulation of DNA metabolic process	26/365	353/18862	6.31352640345199e-09	7.75704159522717e-08	2.98125746404664e-08	KLF4/PTPRC/PARP1/USP9X/PRKDC/MECP2/HSP90AA1/HSP90AB1/KMT2A/HNRNPA1/GJA1/MAPK1/ATM/MAPK3/PPARG/SRC/BRCA1/EGFR/HMGB1/CDKN1A/IL6/BAX/PDGFRB/MYC/ADIPOQ/IL10	26
BP	GO:0032092	positive regulation of protein binding	13/365	83/18862	6.7227965147853e-09	8.22128900896875e-08	3.15968129359437e-08	MMP9/EP300/HSP90AB1/GSK3B/LRRK2/APOE/B2M/BMP4/CSF3/APP/TERT/CAV1/BMP2	13
BP	GO:0048864	stem cell development	13/365	83/18862	6.7227965147853e-09	8.22128900896875e-08	3.15968129359437e-08	EDNRB/PTPRC/EDN1/MAPK1/MAPK3/NRG1/KITLG/BMP4/GDNF/CDH2/FN1/SHH/ERBB4	13
BP	GO:0050803	regulation of synapse structure or activity	20/365	214/18862	7.07241216239874e-09	8.62867255431118e-08	3.3162506790195e-08	MEF2C/DAG1/CLN3/SNCA/CDKL5/DMPK/LRRK2/APOE/NLGN3/TLR2/GHRL/APP/IL1RAPL1/CDH2/ADAM10/NTRK1/GRIN2B/NRXN1/RELN/IL10	20
BP	GO:0008361	regulation of cell size	18/365	173/18862	7.50936451703874e-09	9.1046016653199e-08	3.49916412574188e-08	SPP1/L1CAM/EDN1/AKT3/ATP7A/CLN3/MTOR/HSP90AB1/GSK3B/RTN4/P2RX7/NGF/CDKL5/APOE/CXCL12/VEGFA/TRPV4/FN1	18
BP	GO:0061138	morphogenesis of a branching epithelium	18/365	173/18862	7.50936451703874e-09	9.1046016653199e-08	3.49916412574188e-08	EDN1/BCL2/DAG1/CTNNB1/GLI3/SRC/KDR/NOTCH1/AR/FGFR2/BMP4/MYC/AGT/GDNF/VEGFA/BMP2/SHH/IL10	18
BP	GO:0014823	response to activity	12/365	69/18862	7.53208353283056e-09	9.1046016653199e-08	3.49916412574188e-08	EDN1/PRKDC/MTOR/LEP/CXCR4/IL6/BGLAP/AGT/RYR2/SOD2/ADIPOQ/IL10	12
BP	GO:0051966	regulation of synaptic transmission, glutamatergic	12/365	69/18862	7.53208353283056e-09	9.1046016653199e-08	3.49916412574188e-08	STXBP1/MEF2C/CLN3/EGFR/LRRK2/NLGN3/CCL2/CDH2/CNR1/NTRK1/NRXN1/RELN	12
BP	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	13/365	84/18862	7.81627587471926e-09	9.42635666550245e-08	3.62282396230621e-08	GABARAP/SORT1/BCL2/GSK3B/TNFRSF1A/ICAM1/NGF/BRCA1/ATF3/FAS/FASLG/BAX/SERPINE1	13
BP	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	14/365	100/18862	7.90144760524541e-09	9.50716707261023e-08	3.6538817601026e-08	MIF/BCL2/NUPR1/EP300/PRKDC/TNFRSF1A/ATM/BCL2L11/BRCA1/CDKN1A/BRCA2/CXCL12/BAX/CLU	14
BP	GO:0050671	positive regulation of lymphocyte proliferation	16/365	135/18862	7.95045780641651e-09	9.54419636669359e-08	3.66811319846981e-08	CCL5/PTPRC/MIF/CD4/BCL2/MEF2C/IL18/HMGB1/AGER/VCAM1/LEP/CDKN1A/IL6/IGF1/CD40LG/SHH	16
BP	GO:0042743	hydrogen peroxide metabolic process	11/365	56/18862	8.37700294098128e-09	1.00103272586977e-07	3.84726090368066e-08	HBA1/PINK1/SNCA/EGFR/PRDX1/HBB/MMP3/SOD2/CYP1A1/HP/MPO	11
BP	GO:0043388	positive regulation of DNA binding	11/365	56/18862	8.37700294098128e-09	1.00103272586977e-07	3.84726090368066e-08	MMP9/KLF4/PARP1/CTNNB1/EP300/TXN/NGF/PPARG/HMGB1/IFNG/IGF1	11
BP	GO:0060562	epithelial tube morphogenesis	24/365	309/18862	8.79510731258629e-09	1.04860117708603e-07	4.03008034392816e-08	LRP2/EDN1/BCL2/MEF2C/DAG1/CTNNB1/GLI3/MED12/GATA4/SRC/MTHFR/CXCR4/KDR/NOTCH1/AR/FGFR2/BMP4/MYC/AGT/RYR2/GDNF/VEGFA/BMP2/SHH	24
BP	GO:0032946	positive regulation of mononuclear cell proliferation	16/365	136/18862	8.85383556627418e-09	1.05320398531543e-07	4.04777027922248e-08	CCL5/PTPRC/MIF/CD4/BCL2/MEF2C/IL18/HMGB1/AGER/VCAM1/LEP/CDKN1A/IL6/IGF1/CD40LG/SHH	16
BP	GO:0045124	regulation of bone resorption	10/365	44/18862	8.99922701252708e-09	1.0656550720264e-07	4.09562343913771e-08	SPP1/NF1/P2RX7/SRC/EGFR/TF/PRKCA/IL6/BGLAP/TNFSF11	10
BP	GO:0150076	neuroinflammatory response	10/365	44/18862	8.99922701252708e-09	1.0656550720264e-07	4.09562343913771e-08	MMP9/PTPRC/NUPR1/IL18/ATM/LRRK2/IL6/MMP3/IFNG/IGF1	10
BP	GO:0042509	regulation of tyrosine phosphorylation of STAT protein	13/365	85/18862	9.06808787815416e-09	1.07138537142797e-07	4.11764665205004e-08	CCL5/TNFRSF1A/IL18/LEP/IL6/KIT/IFNG/IGF1/SOCS1/GHR/CAV1/IL24/ERBB4	13
BP	GO:0097529	myeloid leukocyte migration	20/365	218/18862	9.71351717748631e-09	1.14505740781449e-07	4.40078978809302e-08	EDNRB/CCL5/EDN1/MIF/MAPK1/MAPK3/PIK3CG/IL1R1/HMGB1/AGER/IL6/PPIB/CXCL12/CCL2/THBS4/KIT/SERPINE1/TNFSF11/VEGFA/P2RY12	20
BP	GO:0006941	striated muscle contraction	18/365	176/18862	9.86543977592874e-09	1.16035307386991e-07	4.45957549658186e-08	NPPA/NEDD4L/ATP1A1/MTOR/HDAC4/GJA1/GATA4/ANK2/PIK3CG/DMPK/CXCR4/KCNQ1/RYR2/CASQ2/CAV1/KCNH2/SCN5A/NOS1	18
BP	GO:0071887	leukocyte apoptotic process	14/365	102/18862	1.02670536147343e-08	1.20488248025828e-07	4.63071500065076e-08	CCL5/MEF2C/RPS6/GLI3/BCL2L11/FAS/IL6/KITLG/CXCL12/FASLG/BMP4/BAX/CDKN2A/IL10	14
BP	GO:0031058	positive regulation of histone modification	13/365	86/18862	1.04983527342989e-08	1.22927020606981e-07	4.72444414817972e-08	PINK1/CTNNB1/MECP2/KMT2A/BRD4/ATM/MAPK3/DNMT1/BRCA1/LRRK2/TET1/VEGFA/NOS1	13
BP	GO:0043627	response to estrogen	12/365	71/18862	1.05657628753968e-08	1.23440185021935e-07	4.74416655424889e-08	EP300/GLI3/KMT2D/MAPK1/PPARG/BRCA1/CCND1/AR/BGLAP/GHRL/PDGFRB/CAV1	12
BP	GO:0072006	nephron development	16/365	138/18862	1.09483800619766e-08	1.27625437069901e-07	4.90501800455684e-08	BCL2/MEF2C/CTNNB1/GLI3/NOTCH1/STAT1/BMP4/PDGFRB/MYC/AGT/GDNF/ADIPOQ/VEGFA/EGR1/BMP2/SHH	16
BP	GO:0034605	cellular response to heat	15/365	120/18862	1.1257056306e-08	1.3093207267912e-07	5.03210166099788e-08	STUB1/EP300/MTOR/HSP90AA1/HSP90AB1/GSK3B/CREBBP/MAPK1/ATM/MAPK3/CDKN1A/HSPA1B/HSPA1A/CAMK2A/TRPV4	15
BP	GO:0003015	heart process	23/365	289/18862	1.1444860719725e-08	1.32821288263949e-07	5.10470972934871e-08	NPPA/EDN1/NEDD4L/ATP1A1/MTOR/HDAC4/GJA1/GATA4/ANK2/SRC/PIK3CG/DMPK/CXCR4/ITPR1/KCNQ1/AGT/RYR2/CASQ2/NOX4/CAV1/KCNH2/SCN5A/NOS1	23
BP	GO:0032637	interleukin-8 production	14/365	103/18862	1.16762490305988e-08	1.35206830588837e-07	5.19639308278396e-08	KLF4/PTPRC/CD14/DDIT3/HMGB1/LEP/IL6/HSPA1B/HSPA1A/TLR2/SERPINE1/ADIPOQ/NOS2/IL10	14
BP	GO:0002209	behavioral defense response	9/365	34/18862	1.18018671232549e-08	1.36359762744185e-07	5.24070363019403e-08	BCL2/MEF2C/EP300/MECP2/GJA1/EIF4E/APOE/DRD4/HTR2C	9
BP	GO:0032760	positive regulation of tumor necrosis factor production	13/365	87/18862	1.21293906140435e-08	1.39835309413884e-07	5.37427903163391e-08	PTPRC/MIF/HSPB1/CD14/HMGB1/AGER/LEP/IL6/TLR2/APP/IFNG/LPL/CLU	13
BP	GO:0048708	astrocyte differentiation	12/365	72/18862	1.246056098424e-08	1.43337530091235e-07	5.50887959303242e-08	PLP1/NF1/MAPK1/MAPK3/EGFR/AGER/IL6/NOTCH1/APP/IFNG/BMP2/SHH	12
BP	GO:0021700	developmental maturation	22/365	268/18862	1.36790200847887e-08	1.57008752464438e-07	6.03430456648918e-08	EDNRB/STXBP1/BCL2/DAG1/MTOR/MECP2/PPARG/DDIT3/CFTR/LEP/LRRK2/CDKN1A/BRCA2/APP/MMP2/IGF1/AURKA/VEGFA/C3/NRXN1/RELN/BMP2	22
BP	GO:0007260	tyrosine phosphorylation of STAT protein	13/365	88/18862	1.3985922629804e-08	1.59830390926624e-07	6.1427483671697e-08	CCL5/TNFRSF1A/IL18/LEP/IL6/KIT/IFNG/IGF1/SOCS1/GHR/CAV1/IL24/ERBB4	13
BP	GO:0072080	nephron tubule development	13/365	88/18862	1.3985922629804e-08	1.59830390926624e-07	6.1427483671697e-08	BCL2/MEF2C/CTNNB1/GLI3/NOTCH1/STAT1/BMP4/MYC/AGT/GDNF/VEGFA/BMP2/SHH	13
BP	GO:0006953	acute-phase response	10/365	46/18862	1.4284359908924e-08	1.62178611200235e-07	6.23299732525489e-08	EDNRB/CEBPB/SERPINA1/IL6/SERPINA3/TNFSF11/CNR1/FN1/HP/MBL2	10
BP	GO:0034198	cellular response to amino acid starvation	10/365	46/18862	1.4284359908924e-08	1.62178611200235e-07	6.23299732525489e-08	MAP1LC3A/EIF2AK2/MTOR/ATF4/MAPK1/MAPK3/UCP2/ATF3/FAS/CDKN1A	10
BP	GO:0048146	positive regulation of fibroblast proliferation	10/365	46/18862	1.4284359908924e-08	1.62178611200235e-07	6.23299732525489e-08	MIF/NDUFS4/PRKDC/CDKN1A/NGFR/IGF1/PDGFRB/MYC/AGT/FN1	10
BP	GO:0043467	regulation of generation of precursor metabolites and energy	17/365	160/18862	1.43660792663492e-08	1.6275337419929e-07	6.25508714467837e-08	ABCD1/NUPR1/PINK1/EP300/ATP7A/MTOR/GSK3B/P2RX7/HDAC4/SNCA/PPARA/HMGB1/APP/IFNG/IGF1/POMC/NOS2	17
BP	GO:0051146	striated muscle cell differentiation	22/365	269/18862	1.4637339214089e-08	1.6531124382831e-07	6.35339353932586e-08	XBP1/SORT1/EDN1/BCL2/MEF2C/MTOR/HDAC4/GATA4/PPARA/DMPK/NRG1/NOTCH1/BMP4/KRT8/IGF1/PDGFRB/CDH2/VEGFA/GDF15/NOS1/BMP2/SHH	22
BP	GO:0031100	animal organ regeneration	12/365	73/18862	1.46550281116423e-08	1.6531124382831e-07	6.35339353932586e-08	CEBPB/GLI3/PPARG/EGFR/UCP2/CCND1/CDKN1A/IL6/NOTCH1/CXCL12/AURKA/IL10	12
BP	GO:0045428	regulation of nitric oxide biosynthetic process	11/365	59/18862	1.49488713370031e-08	1.67907619329785e-07	6.45317982702611e-08	KLF4/EDN1/MTOR/HSP90AA1/HSP90AB1/ICAM1/HBB/IFNG/CLU/CAV1/IL10	11
BP	GO:0031056	regulation of histone modification	16/365	141/18862	1.49493600702483e-08	1.67907619329785e-07	6.45317982702611e-08	PINK1/CTNNB1/NSD1/MECP2/KMT2A/BRD4/SNCA/ATM/MAPK3/DNMT1/BRCA1/MTHFR/LRRK2/TET1/VEGFA/NOS1	16
BP	GO:0043583	ear development	19/365	202/18862	1.52326926160472e-08	1.70723582767433e-07	6.5614055199518e-08	COL2A1/EDN1/BCL2/GLI3/MAPK1/MAPK3/CHD7/BCL2L11/SOX2/NOTCH1/FGFR2/DLX5/BMP4/KCNQ1/PDGFRB/ADAM10/FOXG1/BMP2/SHH	19
BP	GO:0043409	negative regulation of MAPK cascade	18/365	181/18862	1.53495296680465e-08	1.71665466415717e-07	6.59760485731824e-08	NPPA/KLF4/PIK3R2/PTPRC/IGF1R/DAG1/PINK1/NF1/P2RX7/SORL1/ATF3/APOE/BMP4/MYC/AGT/ADIPOQ/CAV1/UCHL1	18
BP	GO:0050920	regulation of chemotaxis	20/365	224/18862	1.54212685887535e-08	1.72100042203701e-07	6.61430687310243e-08	CCL5/EDN1/MIF/HSPB1/MAPK1/MAPK3/HMGB1/AGER/CXCR4/KDR/IL6/NOTCH1/CXCL12/CCL2/THBS4/SERPINE1/PDGFRB/VEGFA/ADAM10/P2RY12	20
BP	GO:0035821	modulation of process of other organism	15/365	123/18862	1.5832406952406e-08	1.75938042439263e-07	6.76181242285124e-08	CCL5/CD4/EIF2AK2/DAG1/EP300/VAPB/TARDBP/SP1/P2RX7/BCL2L11/APOE/PPIB/JUN/IFNG/NOS2	15
BP	GO:0042476	odontogenesis	15/365	123/18862	1.5832406952406e-08	1.75938042439263e-07	6.76181242285124e-08	EDN1/GLI3/PPARA/SRC/BCL2L11/FGFR2/BGLAP/BMP4/NGFR/BAX/SERPINE1/TNFSF11/SCN5A/BMP2/SHH	15
BP	GO:0033273	response to vitamin	13/365	89/18862	1.6095286423728e-08	1.78480358351255e-07	6.85952104276188e-08	SPP1/CD4/DNMT3A/BCHE/GATA4/PPARG/EGFR/CCND1/MTHFR/LEP/BGLAP/SOD2/CYP1A1	13
BP	GO:1903829	positive regulation of cellular protein localization	23/365	295/18862	1.68317338661542e-08	1.86252209419558e-07	7.15821596043632e-08	PIK3R2/BCL2/HRAS/PARP1/PINK1/GLI3/CLN3/HSP90AB1/GSK3B/TARDBP/HUWE1/RTN4/SORL1/MAPK1/SRC/EGFR/LEP/NGFR/ANK3/TERT/IFNG/SHH/ERBB4	23
BP	GO:0072009	nephron epithelium development	14/365	106/18862	1.70213170718438e-08	1.87952686822849e-07	7.22357026966323e-08	BCL2/MEF2C/CTNNB1/GLI3/NOTCH1/STAT1/BMP4/MYC/AGT/GDNF/ADIPOQ/VEGFA/BMP2/SHH	14
BP	GO:0033157	regulation of intracellular protein transport	21/365	248/18862	1.70878116523339e-08	1.88289697238559e-07	7.23652256345928e-08	PIK3R2/BCL2/HRAS/PINK1/TXN/GLI3/ATP13A2/HSP90AB1/GSK3B/TARDBP/HUWE1/SORL1/UBE2J1/MAPK1/LEP/LRRK2/BMP4/ANK3/IFNG/ADIPOQ/SHH	21
BP	GO:0001774	microglial cell activation	10/365	47/18862	1.7835531729666e-08	1.96115909817378e-07	7.53730675262976e-08	PTPRC/SNCA/ATM/AGER/LRRK2/IL6/TLR2/APP/IFNG/CLU	10
BP	GO:0051348	negative regulation of transferase activity	23/365	296/18862	1.79311903444229e-08	1.96754403066477e-07	7.56184591155073e-08	NPPA/PTPRC/IGF1R/DNAJC3/RPL5/NF1/GSK3B/SORL1/HSPB1/GADD45A/SNCA/PPARG/SRC/APOE/CDKN1A/BMP4/IFNG/AGT/SOCS1/ADIPOQ/CAV1/CDKN2A/UCHL1	23
BP	GO:0014033	neural crest cell differentiation	13/365	90/18862	1.84876671292735e-08	2.01592603655453e-07	7.74779207983371e-08	EDNRB/EDN1/MEF2C/MAPK1/MAPK3/NRG1/KITLG/BMP4/GDNF/CDH2/FN1/SHH/ERBB4	13
BP	GO:0061326	renal tubule development	13/365	90/18862	1.84876671292735e-08	2.01592603655453e-07	7.74779207983371e-08	BCL2/MEF2C/CTNNB1/GLI3/NOTCH1/STAT1/BMP4/MYC/AGT/GDNF/VEGFA/BMP2/SHH	13
BP	GO:1903557	positive regulation of tumor necrosis factor superfamily cytokine production	13/365	90/18862	1.84876671292735e-08	2.01592603655453e-07	7.74779207983371e-08	PTPRC/MIF/HSPB1/CD14/HMGB1/AGER/LEP/IL6/TLR2/APP/IFNG/LPL/CLU	13
BP	GO:0030324	lung development	17/365	163/18862	1.90065521261099e-08	2.06819737688273e-07	7.9486860954144e-08	HSD11B1/DAG1/EP300/ATP7A/GLI3/EIF4E/MAPK1/MAPK3/EGFR/HMGB1/NOTCH1/FGFR2/BMP4/PDGFRB/VEGFA/MME/SHH	17
BP	GO:0021987	cerebral cortex development	14/365	107/18862	1.9244459629555e-08	2.08541411389422e-07	8.01485504022656e-08	GLI3/TRAPPC9/NF1/GSK3B/RTN4/WDR62/SLC2A1/BAX/CDH2/FOXP2/P2RY12/FOXG1/RELN/NPY	14
BP	GO:2000278	regulation of DNA biosynthetic process	14/365	107/18862	1.9244459629555e-08	2.08541411389422e-07	8.01485504022656e-08	KLF4/HSP90AA1/HSP90AB1/HNRNPA1/GJA1/MAPK1/ATM/MAPK3/PPARG/SRC/CDKN1A/PDGFRB/MYC/ADIPOQ	14
BP	GO:0002685	regulation of leukocyte migration	19/365	205/18862	1.93746933556497e-08	2.09518894676592e-07	8.0524225756082e-08	CCL5/EDN1/MIF/ICAM1/MAPK1/MAPK3/IL1R1/HMGB1/AGER/IL6/KITLG/CXCL12/CCL2/THBS4/APP/SERPINE1/VEGFA/ADAM10/P2RY12	19
BP	GO:0001937	negative regulation of endothelial cell proliferation	12/365	75/18862	2.01122713460209e-08	2.16600058076282e-07	8.32457235049726e-08	MEF2C/NF1/GJA1/PPARG/APOE/STAT1/NGFR/CCL2/GHRL/PRL/CAV1/XDH	12
BP	GO:0055117	regulation of cardiac muscle contraction	12/365	75/18862	2.01122713460209e-08	2.16600058076282e-07	8.32457235049726e-08	NPPA/ATP1A1/HDAC4/GATA4/ANK2/PIK3CG/KCNQ1/RYR2/CASQ2/CAV1/SCN5A/NOS1	12
BP	GO:0010675	regulation of cellular carbohydrate metabolic process	16/365	144/18862	2.0247660895452e-08	2.17164461325401e-07	8.34626401449714e-08	NUPR1/EP300/SCARB2/MTOR/GSK3B/RORA/HDAC4/SNCA/PPARA/SRC/HMGB1/LEP/LEPR/IGF1/ADIPOQ/POMC	16
BP	GO:0035051	cardiocyte differentiation	16/365	144/18862	2.0247660895452e-08	2.17164461325401e-07	8.34626401449714e-08	EDN1/MEF2C/MTOR/MAPK1/GATA4/PPARA/MAPK3/EGFR/VCAM1/NRG1/NOTCH1/BMP4/IGF1/PDGFRB/VEGFA/BMP2	16
BP	GO:1903034	regulation of response to wounding	17/365	164/18862	2.0835480248205e-08	2.22556946161438e-07	8.55351294399993e-08	XBP1/SPP1/KLF4/OCLN/EDN1/PLAT/HRAS/ATP7A/MTOR/GJA1/HMGB1/CXCR4/APOE/SERPINE1/CAV1/IL10/PROC	17
BP	GO:1990138	neuron projection extension	17/365	164/18862	2.0835480248205e-08	2.22556946161438e-07	8.55351294399993e-08	L1CAM/NEDD4L/CTNNB1/USP9X/HSP90AA1/HSP90AB1/GSK3B/RTN4/SLC9A6/CDKL5/CXCR4/APOE/NLGN3/CXCL12/AURKA/VEGFA/FN1	17
BP	GO:0006109	regulation of carbohydrate metabolic process	19/365	206/18862	2.09710814240874e-08	2.23549165323163e-07	8.59164682204544e-08	NUPR1/EP300/SCARB2/MTOR/GSK3B/RORA/P2RX7/HDAC4/SNCA/PPARA/SRC/HMGB1/LEP/APP/LEPR/IFNG/IGF1/ADIPOQ/POMC	19
BP	GO:0006942	regulation of striated muscle contraction	13/365	91/18862	2.11963444922127e-08	2.25491193236263e-07	8.6662846222975e-08	NPPA/ATP1A1/HDAC4/GATA4/ANK2/PIK3CG/DMPK/KCNQ1/RYR2/CASQ2/CAV1/SCN5A/NOS1	13
BP	GO:0080164	regulation of nitric oxide metabolic process	11/365	61/18862	2.15725419949854e-08	2.29027758218567e-07	8.80220513556465e-08	KLF4/EDN1/MTOR/HSP90AA1/HSP90AB1/ICAM1/HBB/IFNG/CLU/CAV1/IL10	11
BP	GO:0000082	G1/S transition of mitotic cell cycle	22/365	275/18862	2.18240337208268e-08	2.31228729746574e-07	8.88679489463032e-08	KLF4/BCL2/RPS6/EP300/PRKDC/BRD4/PHF8/EIF4E/GADD45A/ATM/EGFR/CCND1/CDKN1A/CCL2/BAX/TERT/MYC/AURKA/CYP1A1/CAMK2A/GJC2/CDKN2A	22
BP	GO:0002262	myeloid cell homeostasis	16/365	145/18862	2.2363347459841e-08	2.35987420574209e-07	9.06968527074621e-08	RPS6/PRKDC/ETS1/BCL2L11/HMGB1/P4HTM/B2M/IL6/KITLG/STAT1/HSPA1B/BMP4/KIT/HSPA1A/BAX/VEGFA	16
BP	GO:1903169	regulation of calcium ion transmembrane transport	16/365	145/18862	2.2363347459841e-08	2.35987420574209e-07	9.06968527074621e-08	NPPA/PLP1/PSEN2/HTT/SNCA/ANK2/CHD7/PIK3CG/BAX/DRD4/RYR2/CASQ2/CRHR1/GJC2/CALCR/NOS1	16
BP	GO:0048738	cardiac muscle tissue development	19/365	208/18862	2.45332947899249e-08	2.58155494192044e-07	9.92166903447091e-08	LRP2/EDN1/MEF2C/MTOR/GJA1/MAPK1/GATA4/PPARA/CHD7/NRG1/NOTCH1/FGFR2/BMP4/IGF1/PDGFRB/RYR2/VEGFA/BMP2/ERBB4	19
BP	GO:0030968	endoplasmic reticulum unfolded protein response	15/365	127/18862	2.45627504982113e-08	2.58155494192044e-07	9.92166903447091e-08	XBP1/ATF6/STUB1/DNAJC3/EP300/ATF4/VAPB/BCL2L11/DDIT3/ATF3/CCND1/CANX/CCL2/PPP1R15A/BAX	15
BP	GO:0045453	bone resorption	11/365	62/18862	2.57758394855529e-08	2.70362212159086e-07	1.03908088296364e-07	SPP1/NF1/P2RX7/SRC/EGFR/ADRB2/TF/PRKCA/IL6/BGLAP/TNFSF11	11
BP	GO:0010594	regulation of endothelial cell migration	20/365	231/18862	2.59261445242676e-08	2.71394880880033e-07	1.04304973022896e-07	KLF4/EDN1/AKT3/MEF2C/NF1/MECP2/SP1/HSPB1/GADD45A/PPARG/ETS1/PIK3CG/HMGB1/APOE/PRKCA/KDR/NOTCH1/BMP4/AGT/VEGFA	20
BP	GO:0042596	fear response	9/365	37/18862	2.65933625777289e-08	2.77823672119427e-07	1.06775745111965e-07	BCL2/MEF2C/MECP2/GJA1/EIF4E/APOE/DRD4/HTR2C/DBH	9
BP	GO:0030323	respiratory tube development	17/365	167/18862	2.73334731436906e-08	2.84578261553308e-07	1.09371730955166e-07	HSD11B1/DAG1/EP300/ATP7A/GLI3/EIF4E/MAPK1/MAPK3/EGFR/HMGB1/NOTCH1/FGFR2/BMP4/PDGFRB/VEGFA/MME/SHH	17
BP	GO:1990928	response to amino acid starvation	10/365	49/18862	2.73486560109503e-08	2.84578261553308e-07	1.09371730955166e-07	MAP1LC3A/EIF2AK2/MTOR/ATF4/MAPK1/MAPK3/UCP2/ATF3/FAS/CDKN1A	10
BP	GO:0014013	regulation of gliogenesis	13/365	93/18862	2.7712783550666e-08	2.877950577464e-07	1.10608039610114e-07	LRP2/DAG1/NF1/MTOR/PPARG/DICER1/CXCR4/IL6/NOTCH1/TLR2/GJC2/BMP2/SHH	13
BP	GO:0016569	covalent chromatin modification	29/365	461/18862	2.84485307378977e-08	2.94850712637934e-07	1.13319733694888e-07	DNMT3A/HCFC1/PINK1/CTNNB1/NSD1/EP300/CLOCK/MECP2/KMT2A/CREBBP/BRD4/PHF8/HUWE1/KMT2D/HDAC4/KMT2C/SNCA/ATM/MAPK3/DNMT1/BRCA1/MTHFR/LRRK2/PRKCA/BRCA2/TET1/AURKA/VEGFA/NOS1	29
BP	GO:0061180	mammary gland epithelium development	11/365	63/18862	3.06930956042953e-08	3.17485498800161e-07	1.22018942583333e-07	CEBPB/RTN4/MAPK1/SRC/CCND1/BRCA2/AR/FGFR2/BAX/TNFSF11/ERBB4	11
BP	GO:0022612	gland morphogenesis	14/365	111/18862	3.10189978847687e-08	3.20223737532307e-07	1.23071327639973e-07	XBP1/BCL2/DAG1/CEBPB/GLI3/SRC/IL6/NOTCH1/AR/FGFR2/BMP4/BAX/CAV1/SHH	14
BP	GO:0042982	amyloid precursor protein metabolic process	13/365	94/18862	3.16050443949077e-08	3.25631500714463e-07	1.25149688849293e-07	PSEN2/AGO2/ITM2B/CLN3/SP1/RTN4/SORL1/AGER/APOE/IFNG/IGF1/CLU/ADAM10	13
BP	GO:0002931	response to ischemia	10/365	50/18862	3.36029710929848e-08	3.4553624892079e-07	1.32799664478738e-07	BCL2/PINK1/STUB1/ARID1B/P2RX7/GJA1/CAMK2A/EGR1/CAV1/NQO1	10
BP	GO:1900180	regulation of protein localization to nucleus	15/365	130/18862	3.37699301546224e-08	3.46572185155477e-07	1.33197805006158e-07	PIK3R2/PARP1/GLI3/ATP13A2/HSP90AB1/GSK3B/TARDBP/MAPK1/SRC/LEP/BMP4/NGFR/TERT/IFNG/SHH	15
BP	GO:0045429	positive regulation of nitric oxide biosynthetic process	9/365	38/18862	3.42564817114399e-08	3.50877544574709e-07	1.34852480277189e-07	KLF4/EDN1/MTOR/HSP90AA1/HSP90AB1/ICAM1/HBB/IFNG/CLU	9
BP	GO:0007050	cell cycle arrest	20/365	235/18862	3.45719671873442e-08	3.53417336442499e-07	1.35828596412448e-07	MIF/HRAS/EP300/MTOR/HSP90AB1/GADD45A/ATM/BRCA1/DDIT3/SOX2/CCND1/CDKN1A/NOTCH1/PPP1R15A/BAX/IFNG/MYC/AURKA/ADAM10/CDKN2A	20
BP	GO:0051209	release of sequestered calcium ion into cytosol	14/365	112/18862	3.48363996423359e-08	3.55426346448316e-07	1.36600717587984e-07	CCR5/PTPRC/HTT/SNCA/ANK2/CHD7/DDIT3/FASLG/ITPR1/BAX/RYR2/CASQ2/HTR2C/NOS1	14
BP	GO:0071478	cellular response to radiation	18/365	191/18862	3.55356031998576e-08	3.61854760988433e-07	1.39071344900528e-07	MMP9/TRPM1/HRAS/PARP1/EP300/CLOCK/ATF4/CREBBP/GADD45A/ATM/CDKN1A/MMP3/BAX/MMP2/MYC/NOX4/MME/EGR1	18
BP	GO:0032602	chemokine production	13/365	95/18862	3.598322073847e-08	3.6499259175417e-07	1.40277304837242e-07	KLF4/EIF2AK2/IL18/HMGB1/AGER/IL6/TLR2/APP/IFNG/LPL/ADIPOQ/EGR1/IL10	13
BP	GO:0060840	artery development	13/365	95/18862	3.598322073847e-08	3.6499259175417e-07	1.40277304837242e-07	LRP2/AKT3/GLI3/NF1/CHD7/LEP/APOE/NOTCH1/BMP4/NGFR/PDGFRB/VEGFA/SHH	13
BP	GO:0043535	regulation of blood vessel endothelial cell migration	16/365	150/18862	3.63013687068738e-08	3.66797999636636e-07	1.40971175774915e-07	KLF4/AKT3/MEF2C/NF1/MECP2/SP1/HSPB1/GADD45A/PPARG/ETS1/HMGB1/APOE/PRKCA/KDR/NOTCH1/VEGFA	16
BP	GO:0045834	positive regulation of lipid metabolic process	16/365	150/18862	3.63013687068738e-08	3.66797999636636e-07	1.40971175774915e-07	ABCD1/MTOR/MFSD2A/TNFRSF1A/PPARA/PPARG/AGTR1/SRC/APOE/KIT/IFNG/PDGFRB/AGT/ADIPOQ/HTR2C/P2RY12	16
BP	GO:0042310	vasoconstriction	12/365	79/18862	3.67797826488727e-08	3.70202658431154e-07	1.42279685510113e-07	EDNRB/EDN1/GJA1/ICAM1/AGTR1/EGFR/LEP/AGT/CHRM3/CAV1/SLC6A4/DBH	12
BP	GO:1900034	regulation of cellular response to heat	12/365	79/18862	3.67797826488727e-08	3.70202658431154e-07	1.42279685510113e-07	EP300/MTOR/HSP90AA1/HSP90AB1/GSK3B/CREBBP/MAPK1/ATM/MAPK3/HSPA1B/HSPA1A/CAMK2A	12
BP	GO:0072073	kidney epithelium development	15/365	131/18862	3.74749575712156e-08	3.76475869343076e-07	1.44690663538929e-07	BCL2/MEF2C/CTNNB1/GLI3/NOTCH1/FGFR2/STAT1/BMP4/MYC/AGT/GDNF/ADIPOQ/VEGFA/BMP2/SHH	15
BP	GO:0051283	negative regulation of sequestering of calcium ion	14/365	113/18862	3.90742307496747e-08	3.91790275371259e-07	1.50576436706248e-07	CCR5/PTPRC/HTT/SNCA/ANK2/CHD7/DDIT3/FASLG/ITPR1/BAX/RYR2/CASQ2/HTR2C/NOS1	14
BP	GO:2001056	positive regulation of cysteine-type endopeptidase activity	16/365	151/18862	3.98980101526997e-08	3.9928524883218e-07	1.53456973738169e-07	SNCA/NGF/PPARG/BCL2L11/HMGB1/FAS/FASLG/GRIN1/CTSD/NGFR/BAX/NLRP3/MYC/GRIN2B/XDH/GRIN2A	16
BP	GO:0010039	response to iron ion	8/365	28/18862	4.03681030445614e-08	4.03218800258081e-07	1.54968752346639e-07	BCL2/MAP1LC3A/ATP7A/SNCA/CCND1/TF/B2M/CYP1A1	8
BP	GO:0003300	cardiac muscle hypertrophy	13/365	96/18862	4.09003953675046e-08	4.07757465435275e-07	1.56713093829176e-07	EDN1/PARP1/MTOR/TNFRSF1A/HDAC4/GATA4/PPARA/LEP/PRKCA/NOTCH1/IGF1/AGT/RYR2	13
BP	GO:0072584	caveolin-mediated endocytosis	6/365	12/18862	4.22151018561286e-08	4.2006434052277e-07	1.61442985085175e-07	NEDD4L/CLN3/MAPK1/MAPK3/SRC/CAV1	6
BP	GO:0014032	neural crest cell development	12/365	80/18862	4.25255713200294e-08	4.22350740586402e-07	1.62321715355191e-07	EDNRB/EDN1/MAPK1/MAPK3/NRG1/KITLG/BMP4/GDNF/CDH2/FN1/SHH/ERBB4	12
BP	GO:1904407	positive regulation of nitric oxide metabolic process	9/365	39/18862	4.37795274653217e-08	4.33981149154344e-07	1.66791620785945e-07	KLF4/EDN1/MTOR/HSP90AA1/HSP90AB1/ICAM1/HBB/IFNG/CLU	9
BP	GO:0043502	regulation of muscle adaptation	13/365	97/18862	4.64146143117375e-08	4.58366210014404e-07	1.76163511320219e-07	KLF4/EDN1/DAG1/PARP1/MTOR/TNFRSF1A/HDAC4/PPARA/PRKCA/NOTCH1/IGF1/AGT/SCN5A	13
BP	GO:0045807	positive regulation of endocytosis	13/365	97/18862	4.64146143117375e-08	4.58366210014404e-07	1.76163511320219e-07	NEDD4L/CLN3/SNCA/CD14/PPARG/TF/LRRK2/APOE/B2M/SERPINE1/CLU/VEGFA/C3	13
BP	GO:0043620	regulation of DNA-templated transcription in response to stress	14/365	115/18862	4.89779630169729e-08	4.81862139907586e-07	1.85193682875812e-07	RPS27A/ATF6/RPS6KA3/EP300/CEBPB/ATF4/CREBBP/DDIT3/ATF3/NOTCH1/JUN/HSPA1A/VEGFA/EGR1	14
BP	GO:0051282	regulation of sequestering of calcium ion	14/365	115/18862	4.89779630169729e-08	4.81862139907586e-07	1.85193682875812e-07	CCR5/PTPRC/HTT/SNCA/ANK2/CHD7/DDIT3/FASLG/ITPR1/BAX/RYR2/CASQ2/HTR2C/NOS1	14
BP	GO:0071695	anatomical structure maturation	19/365	218/18862	5.2267293828538e-08	5.13258941648345e-07	1.97260390058924e-07	EDNRB/BCL2/DAG1/MTOR/MECP2/PPARG/DDIT3/CFTR/LEP/LRRK2/CDKN1A/BRCA2/APP/MMP2/IGF1/AURKA/VEGFA/C3/BMP2	19
BP	GO:0010634	positive regulation of epithelial cell migration	17/365	175/18862	5.47585651207399e-08	5.35712766059725e-07	2.05890050065389e-07	MMP9/EDN1/AKT3/MTOR/SP1/RTN4/HSPB1/ETS1/SRC/PIK3CG/HMGB1/PRKCA/KDR/BMP4/IFNG/AGT/VEGFA	17
BP	GO:0043534	blood vessel endothelial cell migration	17/365	175/18862	5.47585651207399e-08	5.35712766059725e-07	2.05890050065389e-07	KLF4/AKT3/MEF2C/NF1/MECP2/SP1/HSPB1/GADD45A/PPARG/ETS1/HMGB1/APOE/PRKCA/KDR/NOTCH1/VEGFA/NR4A1	17
BP	GO:0150077	regulation of neuroinflammatory response	9/365	40/18862	5.55335438309222e-08	5.42280911214639e-07	2.08414379931053e-07	MMP9/PTPRC/NUPR1/IL18/ATM/LRRK2/IL6/MMP3/IGF1	9
BP	GO:0001656	metanephros development	12/365	82/18862	5.6483739615717e-08	5.49509095071864e-07	2.11192381932372e-07	BCL2/GLI3/NF1/STAT1/BMP4/PDGFRB/MYC/GDNF/ADIPOQ/FBN1/EGR1/SHH	12
BP	GO:2000177	regulation of neural precursor cell proliferation	12/365	82/18862	5.6483739615717e-08	5.49509095071864e-07	2.11192381932372e-07	LRP2/CTNNB1/GLI3/NF1/LRRK2/NOTCH1/CDH2/VEGFA/GJC2/FOXG1/SHH/SLC6A4	12
BP	GO:0016570	histone modification	28/365	448/18862	5.70248581844569e-08	5.53744170199346e-07	2.1282004489893e-07	HCFC1/PINK1/CTNNB1/NSD1/EP300/CLOCK/MECP2/KMT2A/CREBBP/BRD4/PHF8/HUWE1/KMT2D/HDAC4/KMT2C/SNCA/ATM/MAPK3/DNMT1/BRCA1/MTHFR/LRRK2/PRKCA/BRCA2/TET1/AURKA/VEGFA/NOS1	28
BP	GO:0014897	striated muscle hypertrophy	13/365	99/18862	5.94935121228984e-08	5.74036110232228e-07	2.20618829647002e-07	EDN1/PARP1/MTOR/TNFRSF1A/HDAC4/GATA4/PPARA/LEP/PRKCA/NOTCH1/IGF1/AGT/RYR2	13
BP	GO:0043279	response to alkaloid	13/365	99/18862	5.94935121228984e-08	5.74036110232228e-07	2.20618829647002e-07	MAP1LC3A/DNMT3A/MTOR/HSP90AB1/ICAM1/BCHE/PPARG/CXCR4/DRD4/RYR2/CASQ2/CNR1/NQO1	13
BP	GO:0032922	circadian regulation of gene expression	11/365	67/18862	5.97725793038908e-08	5.74036110232228e-07	2.20618829647002e-07	ARNTL/RAI1/CLOCK/ATF4/KMT2A/HUWE1/RORA/PPARA/AHR/NGFR/EGR1	11
BP	GO:0038034	signal transduction in absence of ligand	11/365	67/18862	5.97725793038908e-08	5.74036110232228e-07	2.20618829647002e-07	COL2A1/BCL2/GSK3B/BCL2L11/FAS/KITLG/HSPA1B/HSPA1A/BAX/TERT/GDNF	11
BP	GO:0042987	amyloid precursor protein catabolic process	11/365	67/18862	5.97725793038908e-08	5.74036110232228e-07	2.20618829647002e-07	PSEN2/CLN3/SP1/RTN4/SORL1/AGER/APOE/IFNG/IGF1/CLU/ADAM10	11
BP	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	11/365	67/18862	5.97725793038908e-08	5.74036110232228e-07	2.20618829647002e-07	COL2A1/BCL2/GSK3B/BCL2L11/FAS/KITLG/HSPA1B/HSPA1A/BAX/TERT/GDNF	11
BP	GO:0001541	ovarian follicle development	10/365	53/18862	6.05794900612269e-08	5.80719873590589e-07	2.23187594962415e-07	GNRH1/BCL2/CEBPB/ICAM1/ATM/SRC/KITLG/KIT/BAX/VEGFA	10
BP	GO:0030534	adult behavior	14/365	117/18862	6.10994973858775e-08	5.8463394756432e-07	2.24691887817593e-07	MECP2/PPARA/CHD7/LEP/NLGN3/CXCL12/GHRL/APP/DRD4/GDNF/GABRG2/NRXN1/NPY/DBH	14
BP	GO:0007596	blood coagulation	24/365	342/18862	6.14885783600697e-08	5.87283246599644e-07	2.25710090753156e-07	EDN1/PLAT/STXBP1/P2RX7/HSPB1/MAPK1/GATA4/MAPK3/SRC/PIK3CG/SERPINA1/APOE/PRKCA/IL6/HBB/ITPR1/SERPINE1/PLA2G4A/CAV1/FN1/P2RY12/CD40LG/SHH/PROC	24
BP	GO:0007517	muscle organ development	23/365	317/18862	6.36060976618546e-08	6.06401302663292e-07	2.330577176336e-07	XBP1/LRP2/BCL2/MEF2C/DAG1/ARNTL/NUPR1/EP300/HDAC4/CHD7/ATF3/FOS/NRG1/NOTCH1/ELN/FGFR2/BMP4/IGF1/RYR2/EGR1/CAV1/BMP2/SHH	23
BP	GO:1905269	positive regulation of chromatin organization	13/365	100/18862	6.72026711887544e-08	6.39525056367164e-07	2.45788142854947e-07	PINK1/CTNNB1/MECP2/KMT2A/BRD4/ATM/MAPK3/DNMT1/BRCA1/LRRK2/TET1/VEGFA/NOS1	13
BP	GO:0002761	regulation of myeloid leukocyte differentiation	14/365	118/18862	6.8124308131512e-08	6.47119108457956e-07	2.48706758695806e-07	CD4/CEBPB/MTOR/FOS/PRKCA/KITLG/JUN/BGLAP/HLA-DRB1/IFNG/MYC/TNFSF11/ADIPOQ/FBN1	14
BP	GO:0010951	negative regulation of endopeptidase activity	20/365	245/18862	6.909040361017e-08	6.55107196550054e-07	2.51776814071386e-07	MMP9/KLF4/RPS6KA3/XIAP/SORL1/SNCA/NGF/SRC/SERPINA1/FURIN/CST3/SERPINA3/C4A/NGFR/APP/SERPINI1/SERPINE1/AGT/VEGFA/C3	20
BP	GO:0008306	associative learning	11/365	68/18862	7.00858251386656e-08	6.62146586237862e-07	2.5448225696369e-07	CLN3/NF1/MTOR/MECP2/FOS/GRIN1/KIT/APP/SLC6A1/GRIN2A/DBH	11
BP	GO:0045685	regulation of glial cell differentiation	11/365	68/18862	7.00858251386656e-08	6.62146586237862e-07	2.5448225696369e-07	DAG1/NF1/MTOR/PPARG/DICER1/CXCR4/IL6/NOTCH1/TLR2/BMP2/SHH	11
BP	GO:0010657	muscle cell apoptotic process	12/365	84/18862	7.44070005220294e-08	7.01704938256399e-07	2.69685686102604e-07	EDN1/NUPR1/ATF4/GATA4/PPARG/DNMT1/DMPK/IFNG/IGF1/SOD2/CAMK2A/CDKN2A	12
BP	GO:0001649	osteoblast differentiation	19/365	223/18862	7.50330299739059e-08	7.06336113099682e-07	2.71465581749591e-07	SPP1/MEF2C/CEBPB/GLI3/NF1/ATF4/HDAC4/PPARG/SOX2/IL6/NOTCH1/FGFR2/DLX5/BGLAP/BMP4/SATB2/IGF1/BMP2/SHH	19
BP	GO:0014896	muscle hypertrophy	13/365	101/18862	7.57987223464626e-08	7.11664767109746e-07	2.73513538995379e-07	EDN1/PARP1/MTOR/TNFRSF1A/HDAC4/GATA4/PPARA/LEP/PRKCA/NOTCH1/IGF1/AGT/RYR2	13
BP	GO:0051208	sequestering of calcium ion	14/365	119/18862	7.58710240823917e-08	7.11664767109746e-07	2.73513538995379e-07	CCR5/PTPRC/HTT/SNCA/ANK2/CHD7/DDIT3/FASLG/ITPR1/BAX/RYR2/CASQ2/HTR2C/NOS1	14
BP	GO:0007599	hemostasis	24/365	346/18862	7.64966195058442e-08	7.16249206607493e-07	2.75275472885168e-07	EDN1/PLAT/STXBP1/P2RX7/HSPB1/MAPK1/GATA4/MAPK3/SRC/PIK3CG/SERPINA1/APOE/PRKCA/IL6/HBB/ITPR1/SERPINE1/PLA2G4A/CAV1/FN1/P2RY12/CD40LG/SHH/PROC	24
BP	GO:0010745	negative regulation of macrophage derived foam cell differentiation	6/365	13/18862	7.71223803333174e-08	7.19533937013517e-07	2.76537890640716e-07	NFKBIA/PPARA/PPARG/CETP/ABCA1/ADIPOQ	6
BP	GO:1902947	regulation of tau-protein kinase activity	6/365	13/18862	7.71223803333174e-08	7.19533937013517e-07	2.76537890640716e-07	HSP90AA1/HSP90AB1/SORL1/IFNG/CLU/EGR1	6
BP	GO:0050817	coagulation	24/365	347/18862	8.0745719071619e-08	7.51998387225719e-07	2.89014926289313e-07	EDN1/PLAT/STXBP1/P2RX7/HSPB1/MAPK1/GATA4/MAPK3/SRC/PIK3CG/SERPINA1/APOE/PRKCA/IL6/HBB/ITPR1/SERPINE1/PLA2G4A/CAV1/FN1/P2RY12/CD40LG/SHH/PROC	24
BP	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	11/365	69/18862	8.19494657880477e-08	7.61853470576628e-07	2.92802522428642e-07	CCL5/TNFRSF1A/IL18/LEP/IL6/KIT/IFNG/IGF1/GHR/IL24/ERBB4	11
BP	GO:0051346	negative regulation of hydrolase activity	28/365	456/18862	8.25739142781712e-08	7.65890413306146e-07	2.94354037332431e-07	MMP9/KLF4/SORT1/HRAS/RPS6KA3/XIAP/GSK3B/SORL1/SNCA/NGF/SRC/SERPINA1/FURIN/CST3/LRRK2/SERPINA3/C4A/NGFR/PPP1R15A/APP/LEPR/SERPINI1/SERPINE1/AGT/VEGFA/CAMK2A/C3/NOS1	28
BP	GO:2000241	regulation of reproductive process	16/365	159/18862	8.26763629189859e-08	7.65890413306146e-07	2.94354037332431e-07	EDNRB/GNRH1/STXBP1/NUPR1/AGO2/HDAC4/GJA1/SRC/NOTCH1/AR/BMP4/IGF1/AURKA/CNR1/VEGFA/SHH	16
BP	GO:1900182	positive regulation of protein localization to nucleus	12/365	85/18862	8.51476436963652e-08	7.8660132834482e-07	3.0231384640246e-07	PIK3R2/PARP1/GLI3/HSP90AB1/TARDBP/MAPK1/SRC/LEP/NGFR/TERT/IFNG/SHH	12
BP	GO:0019058	viral life cycle	24/365	348/18862	8.52126391233307e-08	7.8660132834482e-07	3.0231384640246e-07	CCR5/CCL5/RPS27A/CD4/BCL2/EIF2AK2/DAG1/NEDD4L/SCARB2/HSP90AB1/VAPB/ICAM1/PPARA/EGFR/FURIN/CXCR4/APOE/NOTCH1/PPIB/HSPA1B/CCL2/HSPA1A/HLA-DRB1/CAV1	24
BP	GO:0043200	response to amino acid	13/365	102/18862	8.53707638466029e-08	7.86673552769577e-07	3.02341604356668e-07	XBP1/CYBB/EDN1/DNMT3A/ATP7A/CEBPB/MTOR/ICAM1/MTHFR/GRIN1/MMP2/SOCS1/NQO1	13
BP	GO:0045732	positive regulation of protein catabolic process	19/365	225/18862	8.64542519688345e-08	7.95257565562179e-07	3.05640690985927e-07	LRP2/NUPR1/NEDD4L/STUB1/HSP90AA1/GSK3B/HUWE1/SORL1/GJA1/UBQLN2/FURIN/LRRK2/APOE/HSPA1B/HSPA1A/IFNG/CLU/AURKA/CAV1	19
BP	GO:0045687	positive regulation of glial cell differentiation	9/365	42/18862	8.75184986876562e-08	8.03634775668759e-07	3.08860297307684e-07	DAG1/MTOR/PPARG/DICER1/CXCR4/NOTCH1/TLR2/BMP2/SHH	9
BP	GO:0038083	peptidyl-tyrosine autophosphorylation	7/365	21/18862	8.83235456790435e-08	8.08191325321877e-07	3.10611512316254e-07	IGF1R/MAPK3/EGFR/KDR/VEGFA/NTRK1/CAV1	7
BP	GO:0072111	cell proliferation involved in kidney development	7/365	21/18862	8.83235456790435e-08	8.08191325321877e-07	3.10611512316254e-07	STAT1/BMP4/PDGFRB/MYC/EGR1/BMP2/SHH	7
BP	GO:0044843	cell cycle G1/S phase transition	22/365	298/18862	9.12258066954106e-08	8.33291225556333e-07	3.20258136483751e-07	KLF4/BCL2/RPS6/EP300/PRKDC/BRD4/PHF8/EIF4E/GADD45A/ATM/EGFR/CCND1/CDKN1A/CCL2/BAX/TERT/MYC/AURKA/CYP1A1/CAMK2A/GJC2/CDKN2A	22
BP	GO:0032386	regulation of intracellular transport	24/365	350/18862	9.48411860869103e-08	8.64806215991095e-07	3.32370267031149e-07	PIK3R2/BCL2/HRAS/PINK1/TXN/GLI3/ATP13A2/HSP90AB1/GSK3B/TARDBP/DYNC1H1/HUWE1/SORL1/UBE2J1/MAPK1/MAPK3/SRC/LEP/LRRK2/BMP4/ANK3/IFNG/ADIPOQ/SHH	24
BP	GO:0030522	intracellular receptor signaling pathway	21/365	274/18862	9.55002336737959e-08	8.683582481338e-07	3.33735416644951e-07	RPS27A/NFKBIA/IKBKG/ARNTL/PARP1/EP300/CLOCK/XIAP/RORA/KMT2D/PPARA/PPARG/SRC/BRCA1/LEP/AHR/AR/HSPA1B/HSPA1A/NR4A1/ESR2	21
BP	GO:0051145	smooth muscle cell differentiation	11/365	70/18862	9.55625431648966e-08	8.683582481338e-07	3.33735416644951e-07	EDNRB/MEF2C/MECP2/DNMT1/NOTCH1/FGFR2/BMP4/KIT/SOD2/VEGFA/SHH	11
BP	GO:0032414	positive regulation of ion transmembrane transporter activity	13/365	103/18862	9.60155270978037e-08	8.70962337660147e-07	3.34736244246835e-07	NPPA/PINK1/HTT/ANK2/CFTR/ADRB2/NLGN3/CCL2/ANK3/DRD4/IFNG/RYR2/RELN	13
BP	GO:0010950	positive regulation of endopeptidase activity	17/365	182/18862	9.738567517948e-08	8.7584160455052e-07	3.36611488907758e-07	SNCA/NGF/PPARG/BCL2L11/HMGB1/AGER/FAS/FASLG/GRIN1/CTSD/NGFR/BAX/NLRP3/MYC/GRIN2B/XDH/GRIN2A	17
BP	GO:0034390	smooth muscle cell apoptotic process	8/365	31/18862	9.7390105817425e-08	8.7584160455052e-07	3.36611488907758e-07	EDN1/ATF4/PPARG/DNMT1/IFNG/IGF1/SOD2/CDKN2A	8
BP	GO:0034391	regulation of smooth muscle cell apoptotic process	8/365	31/18862	9.7390105817425e-08	8.7584160455052e-07	3.36611488907758e-07	EDN1/ATF4/PPARG/DNMT1/IFNG/IGF1/SOD2/CDKN2A	8
BP	GO:0097421	liver regeneration	8/365	31/18862	9.7390105817425e-08	8.7584160455052e-07	3.36611488907758e-07	CEBPB/GLI3/EGFR/UCP2/CCND1/IL6/AURKA/IL10	8
BP	GO:1902692	regulation of neuroblast proliferation	8/365	31/18862	9.7390105817425e-08	8.7584160455052e-07	3.36611488907758e-07	CTNNB1/GLI3/NF1/LRRK2/NOTCH1/VEGFA/FOXG1/SHH	8
BP	GO:0030307	positive regulation of cell growth	16/365	161/18862	9.84853109998837e-08	8.84171728599299e-07	3.39812998683358e-07	L1CAM/EDN1/BCL2/NEDD4L/RPS6KA3/MTOR/MFSD2A/NGF/CDKL5/EGFR/CXCR4/CXCL12/IGF1/VEGFA/ADAM10/FN1	16
BP	GO:0071560	cellular response to transforming growth factor beta stimulus	20/365	251/18862	1.0285264001839e-07	9.20223449326926e-07	3.53668727080779e-07	EDN1/RPS27A/MEF2C/PARP1/STUB1/USP9X/EP300/HSP90AB1/CREBBP/PPARA/SRC/FOS/FURIN/JUN/FGFR2/HSPA1A/GDF15/NOX4/FBN1/CAV1	20
BP	GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	20/365	251/18862	1.0285264001839e-07	9.20223449326926e-07	3.53668727080779e-07	LRP2/RPS27A/PARP1/STUB1/EP300/XIAP/HSP90AB1/CREBBP/SORL1/GATA4/PPARA/PPARG/NOTCH1/BMP4/HSPA1A/GDF15/FBN1/CAV1/BMP2/SHH	20
BP	GO:0032731	positive regulation of interleukin-1 beta production	10/365	56/18862	1.0506424955353e-07	9.38406624851835e-07	3.60657052086933e-07	P2RX7/HSPB1/HMGB1/AGER/IL6/APP/NLRP3/IFNG/LPL/EGR1	10
BP	GO:0071868	cellular response to monoamine stimulus	13/365	104/18862	1.07837914000723e-07	9.59904152856774e-07	3.68919179476157e-07	ATF4/GSK3B/MAPK1/SNCA/MAPK3/LRRK2/KCNQ1/APP/DRD4/RYR2/ADIPOQ/CHRM3/HTR2C	13
BP	GO:0071870	cellular response to catecholamine stimulus	13/365	104/18862	1.07837914000723e-07	9.59904152856774e-07	3.68919179476157e-07	ATF4/GSK3B/MAPK1/SNCA/MAPK3/LRRK2/KCNQ1/APP/DRD4/RYR2/ADIPOQ/CHRM3/HTR2C	13
BP	GO:0072028	nephron morphogenesis	11/365	71/18862	1.11145286217971e-07	9.87664563777354e-07	3.79588315543817e-07	BCL2/GLI3/STAT1/BMP4/PDGFRB/MYC/AGT/GDNF/VEGFA/BMP2/SHH	11
BP	GO:0030100	regulation of endocytosis	18/365	206/18862	1.13272146783969e-07	1.00485833265643e-06	3.86196382701452e-07	NEDD4L/CLN3/SNCA/CD14/PPARG/SRC/UBQLN2/TF/LRRK2/APOE/B2M/DRD4/SERPINE1/CLU/ADIPOQ/VEGFA/CAV1/C3	18
BP	GO:0043542	endothelial cell migration	21/365	278/18862	1.22079052696409e-07	1.08115357328765e-06	4.15518870251736e-07	KLF4/EDN1/AKT3/MEF2C/NF1/MECP2/SP1/HSPB1/GADD45A/PPARG/ETS1/PIK3CG/HMGB1/APOE/PRKCA/KDR/NOTCH1/BMP4/AGT/VEGFA/NR4A1	21
BP	GO:1902275	regulation of chromatin organization	17/365	185/18862	1.23575987568907e-07	1.09256202522916e-06	4.19903471273439e-07	PINK1/CTNNB1/NSD1/MECP2/KMT2A/BRD4/PHF8/SNCA/ATM/MAPK3/DNMT1/BRCA1/MTHFR/LRRK2/TET1/VEGFA/NOS1	17
BP	GO:0060993	kidney morphogenesis	12/365	88/18862	1.26170613471531e-07	1.11362055802697e-06	4.2799687999307e-07	BCL2/GLI3/LRRK2/STAT1/BMP4/PDGFRB/MYC/AGT/GDNF/VEGFA/BMP2/SHH	12
BP	GO:2001252	positive regulation of chromosome organization	16/365	164/18862	1.27394302571313e-07	1.11877522669573e-06	4.29977969594661e-07	PINK1/CTNNB1/MECP2/KMT2A/HNRNPA1/BRD4/RAD21/MAPK1/ATM/MAPK3/DNMT1/BRCA1/LRRK2/TET1/VEGFA/NOS1	16
BP	GO:0035994	response to muscle stretch	7/365	22/18862	1.27395879845367e-07	1.11877522669573e-06	4.29977969594661e-07	NPPA/EDN1/NFKBIA/CTNNB1/FOS/RYR2/CDH2	7
BP	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	7/365	22/18862	1.27395879845367e-07	1.11877522669573e-06	4.29977969594661e-07	XBP1/EP300/ATF4/NOTCH1/DLX5/VEGFA/BMP2	7
BP	GO:0060047	heart contraction	21/365	279/18862	1.29711984016775e-07	1.13720690844857e-06	4.37061802796538e-07	NPPA/EDN1/NEDD4L/ATP1A1/MTOR/HDAC4/GJA1/GATA4/ANK2/PIK3CG/DMPK/CXCR4/ITPR1/KCNQ1/AGT/RYR2/CASQ2/CAV1/KCNH2/SCN5A/NOS1	21
BP	GO:0070141	response to UV-A	6/365	14/18862	1.32766330460393e-07	1.16203841744096e-06	4.46605276377064e-07	MMP9/EGFR/CCND1/MMP3/MMP2/MME	6
BP	GO:0003254	regulation of membrane depolarization	9/365	44/18862	1.34478719010888e-07	1.17310269217164e-06	4.50857600052291e-07	ABCD1/BCL2/NEDD4L/PARP1/SRC/LRRK2/KDR/ANK3/SCN5A	9
BP	GO:0048066	developmental pigmentation	9/365	44/18862	1.34478719010888e-07	1.17310269217164e-06	4.50857600052291e-07	EDNRB/BCL2/MEF2C/ZEB2/GLI3/BCL2L11/KITLG/KIT/BAX	9
BP	GO:0048565	digestive tract development	14/365	125/18862	1.41543131110911e-07	1.23267345796091e-06	4.7375238383913e-07	EDNRB/BCL2/GLI3/GATA4/SRC/EGFR/CDKN1A/NOTCH1/FGFR2/BMP4/KIT/CYP1A1/SHH/NPY	14
BP	GO:0032642	regulation of chemokine production	12/365	89/18862	1.43325209894565e-07	1.24405331440821e-06	4.78125994777889e-07	KLF4/EIF2AK2/HMGB1/AGER/IL6/TLR2/APP/IFNG/LPL/ADIPOQ/EGR1/IL10	12
BP	GO:0051149	positive regulation of muscle cell differentiation	12/365	89/18862	1.43325209894565e-07	1.24405331440821e-06	4.78125994777889e-07	EDN1/BCL2/MEF2C/CTNNB1/MTOR/NRG1/BMP4/KIT/IGF1/CDH2/SOD2/SHH	12
BP	GO:0035306	positive regulation of dephosphorylation	10/365	58/18862	1.48763022946861e-07	1.28698456546094e-06	4.9462572744924e-07	PTPRC/MEF2C/PINK1/MTOR/HSP90AB1/SRC/PPP1R15A/IFNG/PDGFRB/BMP2	10
BP	GO:0061005	cell differentiation involved in kidney development	10/365	58/18862	1.48763022946861e-07	1.28698456546094e-06	4.9462572744924e-07	MMP9/MEF2C/CTNNB1/GLI3/NOTCH1/STAT1/BMP4/GDNF/ADIPOQ/SHH	10
BP	GO:0010466	negative regulation of peptidase activity	20/365	257/18862	1.51231959000369e-07	1.3040330698648e-06	5.01177965229698e-07	MMP9/KLF4/RPS6KA3/XIAP/SORL1/SNCA/NGF/SRC/SERPINA1/FURIN/CST3/SERPINA3/C4A/NGFR/APP/SERPINI1/SERPINE1/AGT/VEGFA/C3	20
BP	GO:0071559	response to transforming growth factor beta	20/365	257/18862	1.51231959000369e-07	1.3040330698648e-06	5.01177965229698e-07	EDN1/RPS27A/MEF2C/PARP1/STUB1/USP9X/EP300/HSP90AB1/CREBBP/PPARA/SRC/FOS/FURIN/JUN/FGFR2/HSPA1A/GDF15/NOX4/FBN1/CAV1	20
BP	GO:0046632	alpha-beta T cell differentiation	13/365	107/18862	1.5155449869618e-07	1.30466487857863e-06	5.01420787756925e-07	BCL2/ATP7A/GLI3/MTOR/RORA/IL18/HMGB1/IL6/HLA-DRB1/NLRP3/IFNG/SOCS1/SHH	13
BP	GO:0009411	response to UV	15/365	146/18862	1.60121147948641e-07	1.37614792834678e-06	5.288938099211e-07	MMP9/BCL2/PARP1/EP300/ATF4/CREBBP/EGFR/CCND1/CDKN1A/BRCA2/MMP3/BAX/MMP2/MYC/MME	15
BP	GO:0035249	synaptic transmission, glutamatergic	12/365	90/18862	1.6253098570461e-07	1.39456914619333e-06	5.35973621538412e-07	STXBP1/MEF2C/CLN3/EGFR/LRRK2/NLGN3/CCL2/CDH2/CNR1/NTRK1/NRXN1/RELN	12
BP	GO:0014911	positive regulation of smooth muscle cell migration	9/365	45/18862	1.65255134959363e-07	1.41256943338392e-06	5.42891657220336e-07	CCL5/BCL2/ATP7A/HDAC4/SRC/TERT/IGF1/PDGFRB/NOX4	9
BP	GO:0086009	membrane repolarization	9/365	45/18862	1.65255134959363e-07	1.41256943338392e-06	5.42891657220336e-07	NPPA/NEDD4L/ATP1A1/ANK2/KCNQ1/CASQ2/CAV1/KCNH2/SCN5A	9
BP	GO:0001662	behavioral fear response	8/365	33/18862	1.65708374493261e-07	1.41256943338392e-06	5.42891657220336e-07	BCL2/MEF2C/MECP2/GJA1/EIF4E/APOE/DRD4/HTR2C	8
BP	GO:0010922	positive regulation of phosphatase activity	8/365	33/18862	1.65708374493261e-07	1.41256943338392e-06	5.42891657220336e-07	PTPRC/MEF2C/MTOR/HSP90AB1/PPP1R15A/IFNG/PDGFRB/BMP2	8
BP	GO:0071867	response to monoamine	13/365	108/18862	1.69320271436789e-07	1.43867256607168e-06	5.52923852897648e-07	ATF4/GSK3B/MAPK1/SNCA/MAPK3/LRRK2/KCNQ1/APP/DRD4/RYR2/ADIPOQ/CHRM3/HTR2C	13
BP	GO:0071869	response to catecholamine	13/365	108/18862	1.69320271436789e-07	1.43867256607168e-06	5.52923852897648e-07	ATF4/GSK3B/MAPK1/SNCA/MAPK3/LRRK2/KCNQ1/APP/DRD4/RYR2/ADIPOQ/CHRM3/HTR2C	13
BP	GO:0060333	interferon-gamma-mediated signaling pathway	12/365	91/18862	1.83999538800165e-07	1.56086480726104e-06	5.99885897205689e-07	HSP90AB1/ICAM1/PPARG/VCAM1/HLA-DQA1/B2M/STAT1/HLA-DRB1/IFNG/SOCS1/CAMK2A/HLA-DQB1	12
BP	GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress	13/365	109/18862	1.88931632678084e-07	1.60011030006002e-06	6.14969085416144e-07	RPS27A/ATF6/EP300/CEBPB/ATF4/CREBBP/DDIT3/ATF3/NOTCH1/JUN/HSPA1A/VEGFA/EGR1	13
BP	GO:0050821	protein stabilization	17/365	191/18862	1.96114453085038e-07	1.65826017358173e-06	6.37317778837697e-07	STXBP1/HCFC1/PINK1/USP9X/EP300/RPL5/HSP90AA1/HSP90AB1/RTN4/ANK2/LAMP2/CDKN1A/PPIB/HSPA1B/HSPA1A/IGF1/CLU	17
BP	GO:0032722	positive regulation of chemokine production	10/365	60/18862	2.07688265944564e-07	1.75329094186105e-06	6.73840876434741e-07	EIF2AK2/HMGB1/AGER/IL6/TLR2/APP/IFNG/LPL/ADIPOQ/EGR1	10
BP	GO:0046631	alpha-beta T cell activation	15/365	149/18862	2.0935942373792e-07	1.76455269540141e-06	6.78169096979685e-07	PTPRC/BCL2/ATP7A/GLI3/MTOR/RORA/IL18/HMGB1/AGER/IL6/HLA-DRB1/NLRP3/IFNG/SOCS1/SHH	15
BP	GO:0010092	specification of animal organ identity	8/365	34/18862	2.13064222914801e-07	1.79001307020236e-06	6.87954262043061e-07	LRP2/MEF2C/GLI3/AR/FGFR2/BMP4/GDNF/BMP2	8
BP	GO:0060306	regulation of membrane repolarization	8/365	34/18862	2.13064222914801e-07	1.79001307020236e-06	6.87954262043061e-07	NPPA/NEDD4L/ANK2/KCNQ1/CASQ2/CAV1/KCNH2/SCN5A	8
BP	GO:0046683	response to organophosphorus	14/365	130/18862	2.31498059976923e-07	1.94176417615259e-06	7.46276640715081e-07	NDUFS4/P2RX7/PIK3CG/CFTR/FOS/AHR/JUN/STAT1/KCNQ1/APP/ADIPOQ/NOX4/P2RY12/SLC6A4	14
BP	GO:0043473	pigmentation	12/365	93/18862	2.34664182376653e-07	1.96203247693195e-06	7.54066340208146e-07	EDNRB/BCL2/MEF2C/ZEB2/ATP7A/GLI3/NF1/BCL2L11/KITLG/KIT/BAX/POMC	12
BP	GO:0048709	oligodendrocyte differentiation	12/365	93/18862	2.34664182376653e-07	1.96203247693195e-06	7.54066340208146e-07	PLP1/DAG1/GLI3/NF1/MED12/MTOR/PPARG/CXCR4/NOTCH1/TLR2/CLU/SHH	12
BP	GO:0003170	heart valve development	10/365	61/18862	2.44181545150363e-07	2.03510542566402e-06	7.82150406943252e-07	MATR3/NPPA/MEF2C/MTOR/TNFRSF1A/GATA4/NOTCH1/ELN/BMP4/BMP2	10
BP	GO:0019229	regulation of vasoconstriction	10/365	61/18862	2.44181545150363e-07	2.03510542566402e-06	7.82150406943252e-07	EDN1/GJA1/ICAM1/AGTR1/EGFR/LEP/AGT/CHRM3/CAV1/DBH	10
BP	GO:0017038	protein import	17/365	194/18862	2.45348617608129e-07	2.03711583295333e-06	7.82923065135613e-07	PIK3R2/NFKBIA/GLI3/HSP90AA1/HSP90AB1/TARDBP/MAPK1/LAMP2/LEP/LRRK2/APOE/CDKN1A/BMP4/TXNIP/IFNG/CLU/SHH	17
BP	GO:0009409	response to cold	9/365	47/18862	2.45590387962084e-07	2.03711583295333e-06	7.82923065135613e-07	NFKBIA/DNAJC3/HSP90AA1/PPARG/UCP2/FOS/ADRB2/LPL/SOD2	9
BP	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	9/365	47/18862	2.45590387962084e-07	2.03711583295333e-06	7.82923065135613e-07	MMP9/EDN1/GJA1/DNMT1/JUN/TERT/MMP2/IGF1/IL10	9
BP	GO:0010821	regulation of mitochondrion organization	15/365	151/18862	2.49399503103681e-07	2.06428703770768e-06	7.93365752078389e-07	MMP9/BCL2/PINK1/EP300/HTT/ATP13A2/GSK3B/HUWE1/BCL2L11/LRRK2/KDR/HSPA1A/BAX/IGF1/CLU	15
BP	GO:0030318	melanocyte differentiation	7/365	24/18862	2.500492896268e-07	2.06428703770768e-06	7.93365752078389e-07	EDNRB/BCL2/MEF2C/ZEB2/GLI3/KITLG/KIT	7
BP	GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress	7/365	24/18862	2.500492896268e-07	2.06428703770768e-06	7.93365752078389e-07	ATF6/CEBPB/ATF4/DDIT3/ATF3/NOTCH1/VEGFA	7
BP	GO:0021782	glial cell development	13/365	112/18862	2.60573141865633e-07	2.14728108381844e-06	8.25262786070236e-07	PLP1/DAG1/NF1/MED12/DICER1/EGFR/AGER/IL6/TLR2/APP/IFNG/CLU/SHH	13
BP	GO:0034329	cell junction assembly	26/365	425/18862	2.60922959363494e-07	2.14728108381844e-06	8.25262786070236e-07	CEL/OCLN/BCL2/MEF2C/CTNNB1/MECP2/GJA1/SNCA/SRC/PRKCA/KDR/NLGN3/TLR2/GHRL/APP/IL1RAPL1/AGT/CDH2/GABRG2/VEGFA/NTRK1/CAV1/TRPV4/FN1/NRXN1/ERBB4	26
BP	GO:1904035	regulation of epithelial cell apoptotic process	12/365	94/18862	2.64380153788616e-07	2.17231667963833e-06	8.34884696174577e-07	SORT1/NUPR1/MTOR/ICAM1/PPARA/KDR/IL6/FASLG/CCL2/TERT/SERPINE1/CD40LG	12
BP	GO:1905898	positive regulation of response to endoplasmic reticulum stress	8/365	35/18862	2.71566799437171e-07	2.22786932328238e-06	8.56235198357424e-07	XBP1/ATF6/BCL2L11/UBQLN2/DDIT3/PPP1R15A/BAX/CAV1	8
BP	GO:0034284	response to monosaccharide	17/365	196/18862	2.84158602297136e-07	2.32752132147607e-06	8.94534369475045e-07	XBP1/IGF1R/GJA1/ICAM1/GATA4/CFTR/UCP2/AGER/PLA2G6/LEP/TXNIP/GHRL/HLA-DRB1/LPL/SOD2/ADIPOQ/EGR1	17
BP	GO:2000045	regulation of G1/S transition of mitotic cell cycle	16/365	174/18862	2.88268236285932e-07	2.35599962271e-06	9.05479411740806e-07	KLF4/BCL2/EP300/PRKDC/GADD45A/ATM/EGFR/CCND1/CDKN1A/CCL2/BAX/TERT/AURKA/CYP1A1/GJC2/CDKN2A	16
BP	GO:0006469	negative regulation of protein kinase activity	19/365	243/18862	2.88535681726616e-07	2.35599962271e-06	9.05479411740806e-07	NPPA/PTPRC/IGF1R/DNAJC3/NF1/SORL1/HSPB1/GADD45A/SNCA/APOE/CDKN1A/BMP4/IFNG/AGT/SOCS1/ADIPOQ/CAV1/CDKN2A/UCHL1	19
BP	GO:0051604	protein maturation	21/365	293/18862	2.94366381024731e-07	2.39986548019227e-06	9.22338340938286e-07	PLAT/PARP1/PSEN2/STUB1/EP300/GLI3/CLN3/CREBBP/SORL1/NGF/CASP4/SRC/SPG7/FURIN/LRRK2/SERPINE1/ADAM10/MME/GRIN2A/HP/SHH	21
BP	GO:0060688	regulation of morphogenesis of a branching structure	9/365	48/18862	2.97154731769531e-07	2.417079056727e-06	9.28954020756047e-07	RTN4/LRRK2/AR/FGFR2/BMP4/AGT/GDNF/VEGFA/SHH	9
BP	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	12/365	95/18862	2.97401397121167e-07	2.417079056727e-06	9.28954020756047e-07	XBP1/MMP9/MIF/BCL2/PINK1/HSPB1/SRC/LRRK2/CXCL12/HSPA1A/CLU/SOD2	12
BP	GO:0048675	axon extension	13/365	114/18862	3.20979195533258e-07	2.60465908437376e-06	1.00104649965574e-06	L1CAM/USP9X/HSP90AA1/HSP90AB1/GSK3B/RTN4/SLC9A6/CDKL5/APOE/NLGN3/CXCL12/VEGFA/FN1	13
BP	GO:0009743	response to carbohydrate	18/365	221/18862	3.25311513946875e-07	2.63572827244263e-06	1.01298729534378e-06	XBP1/IGF1R/GJA1/ICAM1/GATA4/CFTR/UCP2/AGER/PLA2G6/LEP/TXNIP/GHRL/HLA-DRB1/LPL/SOD2/ADIPOQ/EGR1/NQO1	18
BP	GO:0035690	cellular response to drug	10/365	63/18862	3.34388217259503e-07	2.70090729804975e-06	1.03803749704826e-06	EDN1/MEF2C/HSP90AB1/EGFR/CXCR4/KCNQ1/MYC/ADIPOQ/NOS2/KCNH2	10
BP	GO:0045665	negative regulation of neuron differentiation	10/365	63/18862	3.34388217259503e-07	2.70090729804975e-06	1.03803749704826e-06	GLI3/GSK3B/EIF4E/SOX2/B2M/NOTCH1/APP/FOXG1/SHH/SLC6A4	10
BP	GO:0055123	digestive system development	14/365	134/18862	3.37472884552214e-07	2.72162261594189e-06	1.04599899826337e-06	EDNRB/BCL2/GLI3/GATA4/SRC/EGFR/CDKN1A/NOTCH1/FGFR2/BMP4/KIT/CYP1A1/SHH/NPY	14
BP	GO:0008211	glucocorticoid metabolic process	7/365	25/18862	3.415432799104e-07	2.75021158007851e-06	1.05698657151218e-06	HSD11B1/ATP1A1/STUB1/MECP2/HSD11B2/CYP17A1/BMP2	7
BP	GO:0001890	placenta development	14/365	135/18862	3.70006866057065e-07	2.97483246842193e-06	1.14331493416614e-06	SPP1/RPS6/CEBPB/HSP90AB1/GJA1/MAPK1/MAPK3/PPARG/LEP/FGFR2/GHRL/KRT8/MME/IL10	14
BP	GO:0032677	regulation of interleukin-8 production	12/365	97/18862	3.74650954980154e-07	3.0029450204688e-06	1.15411940834541e-06	KLF4/PTPRC/CD14/DDIT3/HMGB1/IL6/HSPA1B/HSPA1A/TLR2/SERPINE1/ADIPOQ/IL10	12
BP	GO:0060191	regulation of lipase activity	12/365	97/18862	3.74650954980154e-07	3.0029450204688e-06	1.15411940834541e-06	CCL5/SORT1/HRAS/SNCA/AGTR1/EGFR/FURIN/FGFR2/KIT/PDGFRB/LPL/P2RY12	12
BP	GO:0021543	pallium development	15/365	156/18862	3.81479013541336e-07	3.04833764408451e-06	1.17156511832462e-06	GLI3/TRAPPC9/NF1/GSK3B/RTN4/MFSD2A/WDR62/SLC2A1/BAX/CDH2/FOXP2/P2RY12/FOXG1/RELN/NPY	15
BP	GO:0030856	regulation of epithelial cell differentiation	15/365	156/18862	3.81479013541336e-07	3.04833764408451e-06	1.17156511832462e-06	MMP9/CTNNB1/CEBPB/TNFRSF1A/CCND1/NOTCH1/STAT1/BMP4/IFNG/SERPINE1/GDNF/VEGFA/CAV1/XDH/PROC	15
BP	GO:0010660	regulation of muscle cell apoptotic process	11/365	80/18862	3.89333528155347e-07	3.10348335092201e-06	1.1927592228168e-06	EDN1/NUPR1/ATF4/GATA4/PPARG/DNMT1/IFNG/IGF1/SOD2/CAMK2A/CDKN2A	11
BP	GO:0032732	positive regulation of interleukin-1 production	10/365	64/18862	3.89566022460023e-07	3.10348335092201e-06	1.1927592228168e-06	P2RX7/HSPB1/HMGB1/AGER/IL6/APP/NLRP3/IFNG/LPL/EGR1	10
BP	GO:0033044	regulation of chromosome organization	20/365	273/18862	3.99735474330111e-07	3.17965877301489e-06	1.22203566060605e-06	PARP1/PINK1/CTNNB1/MECP2/KMT2A/HNRNPA1/BRD4/PHF8/RAD21/MAPK1/ATM/MAPK3/DNMT1/SRC/BRCA1/LRRK2/TET1/MYC/VEGFA/NOS1	20
BP	GO:0045598	regulation of fat cell differentiation	14/365	136/18862	4.05332822162334e-07	3.2192898197233e-06	1.23726702843578e-06	XBP1/SORT1/ARNTL/CEBPB/MTOR/RORA/PPARG/DDIT3/LEP/IL6/LPL/ADIPOQ/HTR2C/BMP2	14
BP	GO:0071383	cellular response to steroid hormone stimulus	17/365	201/18862	4.06801553397879e-07	3.22605959164318e-06	1.23986884935143e-06	EDN1/ARNTL/ATP1A1/PARP1/EP300/CLOCK/KMT2D/EIF4E/ICAM1/PPARA/SRC/BCL2L11/BRCA1/EGFR/AR/BMP4/ESR2	17
BP	GO:0030168	platelet activation	15/365	157/18862	4.14465026393719e-07	3.28186073849429e-06	1.26131485856899e-06	STXBP1/HSPB1/MAPK1/MAPK3/SRC/PIK3CG/APOE/PRKCA/IL6/HBB/ITPR1/PLA2G4A/FN1/P2RY12/CD40LG	15
BP	GO:0051817	modulation of process of other organism involved in symbiotic interaction	12/365	98/18862	4.19589794638747e-07	3.31690216067137e-06	1.27478229974921e-06	CCL5/CD4/EIF2AK2/DAG1/EP300/VAPB/TARDBP/SP1/BCL2L11/APOE/PPIB/JUN	12
BP	GO:0006352	DNA-templated transcription, initiation	19/365	249/18862	4.20157839611219e-07	3.31690216067137e-06	1.27478229974921e-06	NPPA/CTNNB1/MED12/MECP2/CREBBP/SETX/RORA/PPARA/MAPK3/PPARG/HMGB1/CCND1/CDKN1A/NOTCH1/AR/JUN/BAX/NR4A1/ESR2	19
BP	GO:0034248	regulation of cellular amide metabolic process	28/365	494/18862	4.25031911087376e-07	3.35032684131223e-06	1.2876283799746e-06	CCL5/EIF2AK2/AGO1/PINK1/PURA/RPS6KA3/AGO2/DNAJC3/PRKDC/RPL5/MTOR/ATF4/TARDBP/SP1/RTN4/TNFRSF1A/SORL1/HSPB1/EIF4E/MAPK1/MAPK3/APOE/IL6/PPP1R15A/APP/IFNG/IGF1/CLU	28
BP	GO:0048713	regulation of oligodendrocyte differentiation	8/365	37/18862	4.30678005972996e-07	3.38972734325212e-06	1.30277114272164e-06	DAG1/NF1/MTOR/PPARG/CXCR4/NOTCH1/TLR2/SHH	8
BP	GO:0030183	B cell differentiation	14/365	137/18862	4.43660283180001e-07	3.48666354679298e-06	1.3400265546973e-06	XBP1/PTPRC/BCL2/EP300/PRKDC/HDAC4/ATM/VCAM1/IL6/KIT/BAX/NTRK1/CD40LG/IL10	14
BP	GO:0034504	protein localization to nucleus	20/365	275/18862	4.48953705643429e-07	3.52297405597857e-06	1.35398174305152e-06	PIK3R2/NFKBIA/PARP1/TXN/GLI3/ATP13A2/HSP90AB1/GSK3B/TARDBP/MAPK1/SRC/LEP/LRRK2/CDKN1A/BMP4/NGFR/TXNIP/TERT/IFNG/SHH	20
BP	GO:0032768	regulation of monooxygenase activity	10/365	65/18862	4.52560376524811e-07	3.54065920886526e-06	1.36077866342367e-06	HSP90AA1/SNCA/EGFR/LEP/APOE/TERT/IFNG/GDNF/CNR1/CAV1	10
BP	GO:2000573	positive regulation of DNA biosynthetic process	10/365	65/18862	4.52560376524811e-07	3.54065920886526e-06	1.36077866342367e-06	KLF4/HSP90AA1/HSP90AB1/HNRNPA1/MAPK1/ATM/MAPK3/SRC/PDGFRB/MYC	10
BP	GO:0033598	mammary gland epithelial cell proliferation	7/365	26/18862	4.5964213954909e-07	3.59069695283573e-06	1.38000962871691e-06	CEBPB/RTN4/MAPK1/CCND1/BRCA2/BAX/TNFSF11	7
BP	GO:0035637	multicellular organismal signaling	17/365	203/18862	4.68066893168083e-07	3.65106127994299e-06	1.40320940127729e-06	NPPA/ATP1A1/GJA1/ANK2/DMPK/ANK3/ITPR1/KCNQ1/GHRL/AGT/RYR2/CASQ2/KCNA2/CAV1/KCNH2/SCN5A/NOS1	17
BP	GO:0042102	positive regulation of T cell proliferation	12/365	99/18862	4.69258247399555e-07	3.65490724239475e-06	1.40468751688682e-06	CCL5/PTPRC/CD4/IL18/HMGB1/AGER/VCAM1/LEP/IL6/IGF1/CD40LG/SHH	12
BP	GO:0045165	cell fate commitment	19/365	251/18862	4.74959882764351e-07	3.688338318084e-06	1.41753605491594e-06	KLF4/BCL2/MEF2C/PRKDC/GLI3/MTOR/GATA4/PPARG/SOX2/IL6/NOTCH1/AR/FGFR2/BMP4/SATB2/FOXG1/BMP2/SHH/ERBB4	19
BP	GO:1903362	regulation of cellular protein catabolic process	19/365	251/18862	4.74959882764351e-07	3.688338318084e-06	1.41753605491594e-06	LRP2/NUPR1/PINK1/STUB1/RPL5/ATP13A2/HSP90AA1/HSP90AB1/GSK3B/UBQLN2/FURIN/LRRK2/APOE/HSPA1B/HSPA1A/CLU/AURKA/CAV1/SHH	19
BP	GO:0008637	apoptotic mitochondrial changes	13/365	118/18862	4.80636932515852e-07	3.72138122010054e-06	1.4302354064743e-06	MMP9/BCL2/PINK1/GSK3B/BCL2L11/JUN/HSPA1A/BAX/IGF1/CLU/SOD2/CAMK2A/ERBB4	13
BP	GO:0043500	muscle adaptation	13/365	118/18862	4.80636932515852e-07	3.72138122010054e-06	1.4302354064743e-06	KLF4/EDN1/DAG1/PARP1/MTOR/TNFRSF1A/HDAC4/PPARA/PRKCA/NOTCH1/IGF1/AGT/SCN5A	13
BP	GO:0001889	liver development	14/365	138/18862	4.85212176593667e-07	3.74572349895465e-06	1.43959085463515e-06	XBP1/HRAS/ATP7A/CEBPB/GLI3/NF1/EGFR/UCP2/CCND1/IL6/NOTCH1/AURKA/CYP1A1/IL10	14
BP	GO:0061351	neural precursor cell proliferation	14/365	138/18862	4.85212176593667e-07	3.74572349895465e-06	1.43959085463515e-06	LRP2/CTNNB1/GLI3/NF1/RORA/LRRK2/NOTCH1/FGFR2/CDH2/VEGFA/GJC2/FOXG1/SHH/SLC6A4	14
BP	GO:0007411	axon guidance	20/365	277/18862	5.03659722904796e-07	3.8824079376785e-06	1.49212267339131e-06	L1CAM/DAG1/GLI3/MAPK1/MAPK3/SRC/CXCR4/PRKCA/NOTCH1/CXCL12/DLX5/NGFR/APP/GDNF/VEGFA/NTRK1/FOXG1/NRXN1/RELN/SHH	20
BP	GO:0090399	replicative senescence	6/365	17/18862	5.2087639423676e-07	4.00921624622824e-06	1.54085880709976e-06	ATM/CDKN1A/TERT/SERPINE1/MME/CDKN2A	6
BP	GO:0051048	negative regulation of secretion	15/365	160/18862	5.29438330375288e-07	4.04588226317665e-06	1.55495062746226e-06	EDN1/TNFRSF1A/GJA1/SNCA/UCP2/LEP/APOE/NRG1/NOTCH1/GHRL/DRD4/IL1RAPL1/ADIPOQ/CNR1/P2RY12	15
BP	GO:1903531	negative regulation of secretion by cell	14/365	139/18862	5.30225526476649e-07	4.04588226317665e-06	1.55495062746226e-06	EDN1/TNFRSF1A/GJA1/SNCA/UCP2/LEP/APOE/NOTCH1/GHRL/DRD4/IL1RAPL1/ADIPOQ/CNR1/P2RY12	14
BP	GO:0002688	regulation of leukocyte chemotaxis	13/365	119/18862	5.30278034493538e-07	4.04588226317665e-06	1.55495062746226e-06	CCL5/EDN1/MIF/MAPK1/MAPK3/HMGB1/IL6/CXCL12/CCL2/THBS4/SERPINE1/VEGFA/ADAM10	13
BP	GO:0032652	regulation of interleukin-1 production	13/365	119/18862	5.30278034493538e-07	4.04588226317665e-06	1.55495062746226e-06	P2RX7/HSPB1/HMGB1/AGER/IL6/GHRL/APP/NLRP3/IFNG/IGF1/LPL/EGR1/IL10	13
BP	GO:1903578	regulation of ATP metabolic process	13/365	119/18862	5.30278034493538e-07	4.04588226317665e-06	1.55495062746226e-06	ABCD1/NUPR1/PARP1/PINK1/EP300/ATP7A/P2RX7/HDAC4/SNCA/PPARA/APP/IFNG/IGF1	13
BP	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	13/365	119/18862	5.30278034493538e-07	4.04588226317665e-06	1.55495062746226e-06	KLF4/BCL2/EP300/PRKDC/GADD45A/ATM/CCND1/CDKN1A/CCL2/BAX/AURKA/GJC2/CDKN2A	13
BP	GO:0097485	neuron projection guidance	20/365	278/18862	5.33239619820181e-07	4.06255628841168e-06	1.56135894196946e-06	L1CAM/DAG1/GLI3/MAPK1/MAPK3/SRC/CXCR4/PRKCA/NOTCH1/CXCL12/DLX5/NGFR/APP/GDNF/VEGFA/NTRK1/FOXG1/NRXN1/RELN/SHH	20
BP	GO:0032094	response to food	8/365	38/18862	5.36390412442741e-07	4.06879336047146e-06	1.56375603078273e-06	MTOR/HSD11B2/PPARA/LEP/GHRL/CYP1A1/NPY/MPO	8
BP	GO:0042307	positive regulation of protein import into nucleus	8/365	38/18862	5.36390412442741e-07	4.06879336047146e-06	1.56375603078273e-06	PIK3R2/GLI3/HSP90AB1/TARDBP/MAPK1/LEP/IFNG/SHH	8
BP	GO:0071276	cellular response to cadmium ion	8/365	38/18862	5.36390412442741e-07	4.06879336047146e-06	1.56375603078273e-06	MMP9/CYBB/ATP7A/MAPK1/MAPK3/EGFR/FOS/JUN	8
BP	GO:0055067	monovalent inorganic cation homeostasis	15/365	161/18862	5.73714325516595e-07	4.34561617909386e-06	1.6701471186872e-06	EDNRB/EDN1/BCL2/NEDD4L/ATP1A1/CLN3/MAPK1/MAPK3/SLC9A6/AGTR1/CFTR/LRRK2/FASLG/AGT/KCNH2	15
BP	GO:0061008	hepaticobiliary system development	14/365	140/18862	5.78952180351551e-07	4.37895334098268e-06	1.68295956290206e-06	XBP1/HRAS/ATP7A/CEBPB/GLI3/NF1/EGFR/UCP2/CCND1/IL6/NOTCH1/AURKA/CYP1A1/IL10	14
BP	GO:0062014	negative regulation of small molecule metabolic process	12/365	101/18862	5.84526967627281e-07	4.41473903111282e-06	1.69671304797711e-06	NUPR1/PARP1/EP300/MFSD2A/HDAC4/PPARA/BRCA1/APOE/LEPR/ADIPOQ/CNR1/BMP2	12
BP	GO:0050435	amyloid-beta metabolic process	10/365	67/18862	6.05793580612597e-07	4.56219223154868e-06	1.75338361613127e-06	PSEN2/SP1/RTN4/SORL1/APOE/IFNG/IGF1/CLU/ADAM10/MME	10
BP	GO:1901224	positive regulation of NIK/NF-kappaB signaling	10/365	67/18862	6.05793580612597e-07	4.56219223154868e-06	1.75338361613127e-06	EDN1/EIF2AK2/EP300/IL18/CD14/EGFR/HMGB1/AGER/TLR2/APP	10
BP	GO:0001658	branching involved in ureteric bud morphogenesis	9/365	52/18862	6.08906059540669e-07	4.57904355694807e-06	1.75986007226591e-06	BCL2/GLI3/BMP4/MYC/AGT/GDNF/VEGFA/BMP2/SHH	9
BP	GO:0035235	ionotropic glutamate receptor signaling pathway	7/365	27/18862	6.10252669753212e-07	4.58258604517692e-06	1.76122155387509e-06	PLP1/CLN3/GRIN1/APP/GRIN2B/GRIA1/GRIN2A	7
BP	GO:0072203	cell proliferation involved in metanephros development	5/365	10/18862	6.14347286088458e-07	4.60672449195844e-06	1.77049866342187e-06	STAT1/PDGFRB/MYC/EGR1/SHH	5
BP	GO:0002064	epithelial cell development	17/365	207/18862	6.16371455418684e-07	4.61529069765579e-06	1.77379090626475e-06	ARNTL/CLOCK/ATF4/GSK3B/TNFRSF1A/ICAM1/SRC/CXCR4/CDKN1A/NOTCH1/AR/BMP4/CDH2/ADIPOQ/VEGFA/NTRK1/PROC	17
BP	GO:0062013	positive regulation of small molecule metabolic process	14/365	141/18862	6.31659564130543e-07	4.72300879808466e-06	1.81519011586988e-06	ABCD1/PINK1/P2RX7/SNCA/PPARA/PPARG/SRC/HMGB1/APP/IFNG/IGF1/ADIPOQ/NOS2/NOS1	14
BP	GO:1900407	regulation of cellular response to oxidative stress	11/365	84/18862	6.44146541560661e-07	4.80950499076819e-06	1.84843312699516e-06	ABCD1/PARP1/PINK1/TXN/ATF4/HSPB1/GATA4/LRRK2/MMP3/SOD2/IL10	11
BP	GO:0046620	regulation of organ growth	12/365	102/18862	6.51081128131369e-07	4.8543570151561e-06	1.86567106891445e-06	EDN1/MEF2C/MTOR/GJA1/MAPK1/PPARA/BCL2L11/NOTCH1/FGFR2/IGF1/SLC6A4/ERBB4	12
BP	GO:0034250	positive regulation of cellular amide metabolic process	15/365	163/18862	6.72411119520918e-07	4.99914744257456e-06	1.92131825568851e-06	CCL5/PINK1/AGO2/DNAJC3/PRKDC/RPL5/MTOR/SP1/TNFRSF1A/MAPK1/MAPK3/IL6/PPP1R15A/IFNG/CLU	15
BP	GO:0051170	import into nucleus	15/365	163/18862	6.72411119520918e-07	4.99914744257456e-06	1.92131825568851e-06	PIK3R2/SMN1/NFKBIA/GLI3/HSP90AB1/HNRNPA1/TARDBP/MAPK1/LEP/LRRK2/CDKN1A/BMP4/TXNIP/IFNG/SHH	15
BP	GO:1903201	regulation of oxidative stress-induced cell death	10/365	68/18862	6.98156986728791e-07	5.1831966929624e-06	1.99205375384654e-06	PARP1/PINK1/TXN/ATF4/HSPB1/GATA4/LRRK2/MMP3/SOD2/IL10	10
BP	GO:0015918	sterol transport	13/365	122/18862	7.07840334368974e-07	5.23281964701583e-06	2.01112530326956e-06	CEL/NFKBIA/CETP/CFTR/GRAMD1B/LEP/FURIN/APOE/ABCA1/CLU/ADIPOQ/CAV1/SHH	13
BP	GO:0035270	endocrine system development	13/365	122/18862	7.07840334368974e-07	5.23281964701583e-06	2.01112530326956e-06	ARNTL/CLOCK/NF1/GSK3B/MAPK1/MAPK3/ETS1/SOX2/IL6/BMP4/CDH2/BMP2/SHH	13
BP	GO:0097237	cellular response to toxic substance	13/365	122/18862	7.07840334368974e-07	5.23281964701583e-06	2.01112530326956e-06	HBA1/PTGS1/PINK1/ATP7A/TXN/APOE/PRDX1/HBB/GSTM1/SOD2/HP/NQO1/MPO	13
BP	GO:0006984	ER-nucleus signaling pathway	9/365	53/18862	7.21063766934192e-07	5.32305748396835e-06	2.04580633748236e-06	XBP1/ATF6/ATF4/GSK3B/BCL2L11/DDIT3/ATF3/CCL2/PPP1R15A	9
BP	GO:0032651	regulation of interleukin-1 beta production	12/365	103/18862	7.2427659200393e-07	5.33924462330785e-06	2.05202752753078e-06	P2RX7/HSPB1/HMGB1/AGER/IL6/GHRL/APP/NLRP3/IFNG/IGF1/LPL/EGR1	12
BP	GO:0019915	lipid storage	11/365	85/18862	7.27240972324272e-07	5.35355731244056e-06	2.05752831166139e-06	NFKBIA/BSCL2/PPARA/PPARG/LEP/APOE/IL6/ABCA1/LPL/CAV1/C3	11
BP	GO:0072088	nephron epithelium morphogenesis	10/365	69/18862	8.02598939430612e-07	5.90000400137616e-06	2.26754372154332e-06	BCL2/GLI3/STAT1/BMP4/MYC/AGT/GDNF/VEGFA/BMP2/SHH	10
BP	GO:0045776	negative regulation of blood pressure	8/365	40/18862	8.15511366685187e-07	5.96977131920318e-06	2.29435733785115e-06	NPPA/PPARA/ADRB2/SOD2/ADIPOQ/CNR1/NOS2/NOS1	8
BP	GO:0055023	positive regulation of cardiac muscle tissue growth	8/365	40/18862	8.15511366685187e-07	5.96977131920318e-06	2.29435733785115e-06	EDN1/MEF2C/MTOR/MAPK1/NOTCH1/FGFR2/IGF1/ERBB4	8
BP	GO:1904591	positive regulation of protein import	8/365	40/18862	8.15511366685187e-07	5.96977131920318e-06	2.29435733785115e-06	PIK3R2/GLI3/HSP90AB1/TARDBP/MAPK1/LEP/IFNG/SHH	8
BP	GO:0007589	body fluid secretion	11/365	86/18862	8.1963921792718e-07	5.99160847294813e-06	2.30274999332379e-06	XBP1/CEL/EDN1/ATP7A/CCND1/PRL/VEGFA/CHRM3/CAV1/XDH/ERBB4	11
BP	GO:0086002	cardiac muscle cell action potential involved in contraction	9/365	54/18862	8.50660410680663e-07	6.2097023563495e-06	2.38656983749651e-06	NEDD4L/ATP1A1/GJA1/ANK2/KCNQ1/RYR2/CAV1/KCNH2/SCN5A	9
BP	GO:0046887	positive regulation of hormone secretion	13/365	124/18862	8.53968462468905e-07	6.21651033736057e-06	2.38918634328099e-06	SPP1/EDN1/TARDBP/GJA1/CFTR/EGFR/PLA2G6/LEP/GHRL/ACSL4/HLA-DRB1/CYP19A1/TNFSF11	13
BP	GO:1902807	negative regulation of cell cycle G1/S phase transition	13/365	124/18862	8.53968462468905e-07	6.21651033736057e-06	2.38918634328099e-06	KLF4/BCL2/EP300/PRKDC/GADD45A/ATM/CCND1/CDKN1A/CCL2/BAX/AURKA/GJC2/CDKN2A	13
BP	GO:0002460	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	23/365	367/18862	8.57830697803814e-07	6.23595260042384e-06	2.39665857237294e-06	PTPRC/CD4/HRAS/MEF2C/MTOR/RORA/ICAM1/IL18/IL1R1/HMGB1/AGER/B2M/IL6/C4A/HLA-DRB1/NLRP3/CLU/PLA2G4A/HLA-DQB1/C3/CD40LG/IL10/MBL2	23
BP	GO:0001764	neuron migration	14/365	145/18862	8.88234871825502e-07	6.44801847314102e-06	2.4781616761202e-06	GNRH1/MEF2C/USP9X/CDKL5/CXCR4/CXCL12/BAX/SATB2/ASTN2/VEGFA/CAMK2A/FOXG1/RELN/ERBB4	14
BP	GO:0071772	response to BMP	15/365	167/18862	9.16905573009413e-07	6.63773688676524e-06	2.551075999157e-06	LRP2/COL2A1/USP9X/XIAP/SORL1/GATA4/MAPK3/PPARG/NOTCH1/DLX5/BMP4/GDF15/FBN1/EGR1/BMP2	15
BP	GO:0071773	cellular response to BMP stimulus	15/365	167/18862	9.16905573009413e-07	6.63773688676524e-06	2.551075999157e-06	LRP2/COL2A1/USP9X/XIAP/SORL1/GATA4/MAPK3/PPARG/NOTCH1/DLX5/BMP4/GDF15/FBN1/EGR1/BMP2	15
BP	GO:0006801	superoxide metabolic process	10/365	70/18862	9.20438338808232e-07	6.64493002113419e-06	2.5538405306171e-06	CYBB/EDN1/ATP7A/EGFR/PRDX1/SOD2/NOX4/NOS2/NQO1/MPO	10
BP	GO:0055021	regulation of cardiac muscle tissue growth	10/365	70/18862	9.20438338808232e-07	6.64493002113419e-06	2.5538405306171e-06	EDN1/MEF2C/MTOR/GJA1/MAPK1/PPARA/NOTCH1/FGFR2/IGF1/ERBB4	10
BP	GO:0071674	mononuclear cell migration	16/365	190/18862	9.46483743497204e-07	6.82354809017131e-06	2.62248866728021e-06	CCR5/CCL5/ICAM1/MAPK1/MAPK3/PIK3CG/HMGB1/AGER/CXCR4/IL6/CXCL12/CCL2/APP/SERPINE1/TNFSF11/ADAM10	16
BP	GO:0032535	regulation of cellular component size	23/365	370/18862	9.86973423139485e-07	7.10566560758193e-06	2.73091466244777e-06	SPP1/L1CAM/EDN1/AKT3/ATP7A/ATP13A2/CLN3/MTOR/HSP90AB1/GSK3B/RTN4/P2RX7/ICAM1/NGF/CDKL5/APOE/ELN/CXCL12/PPP1R15A/CSF3/VEGFA/TRPV4/FN1	23
BP	GO:1901222	regulation of NIK/NF-kappaB signaling	12/365	106/18862	9.89597479720257e-07	7.11477089128548e-06	2.73441408870071e-06	EDN1/NFKBIA/EIF2AK2/EP300/IL18/CD14/EGFR/HMGB1/AGER/TLR2/APP/NLRP3	12
BP	GO:0001836	release of cytochrome c from mitochondria	9/365	55/18862	9.99915968678799e-07	7.16926052063676e-06	2.75535604346818e-06	MMP9/BCL2/PINK1/BCL2L11/JUN/BAX/IGF1/CLU/SOD2	9
BP	GO:0007405	neuroblast proliferation	9/365	55/18862	9.99915968678799e-07	7.16926052063676e-06	2.75535604346818e-06	CTNNB1/GLI3/NF1/LRRK2/NOTCH1/FGFR2/VEGFA/FOXG1/SHH	9
BP	GO:0032612	interleukin-1 production	13/365	126/18862	1.02641593196512e-06	7.34919423790076e-06	2.82450982214033e-06	P2RX7/HSPB1/HMGB1/AGER/IL6/GHRL/APP/NLRP3/IFNG/IGF1/LPL/EGR1/IL10	13
BP	GO:0034644	cellular response to UV	11/365	88/18862	1.0359457356355e-06	7.40729505507678e-06	2.84683966177659e-06	MMP9/PARP1/EP300/ATF4/CREBBP/CDKN1A/MMP3/BAX/MMP2/MYC/MME	11
BP	GO:0060055	angiogenesis involved in wound healing	7/365	29/18862	1.03738781024128e-06	7.40748676507895e-06	2.84691334152522e-06	XBP1/DAG1/ETS1/CXCR4/KDR/SERPINE1/VEGFA	7
BP	GO:0061333	renal tubule morphogenesis	10/365	71/18862	1.05310933103614e-06	7.49928467842609e-06	2.88219395862523e-06	BCL2/MEF2C/GLI3/BMP4/MYC/AGT/GDNF/VEGFA/BMP2/SHH	10
BP	GO:2001259	positive regulation of cation channel activity	10/365	71/18862	1.05310933103614e-06	7.49928467842609e-06	2.88219395862523e-06	NPPA/PINK1/HTT/ANK2/ADRB2/NLGN3/CCL2/ANK3/IFNG/RELN	10
BP	GO:0007613	memory	12/365	107/18862	1.09545554048119e-06	7.79023681912846e-06	2.99401535735062e-06	CEBPB/MTOR/MECP2/NGF/APOE/SLC2A4/CNR1/GRIA1/SLC6A1/GRIN2A/SLC6A4/DBH	12
BP	GO:0051900	regulation of mitochondrial depolarization	6/365	19/18862	1.10508378462767e-06	7.84804413669096e-06	3.01623239652001e-06	ABCD1/BCL2/PARP1/SRC/LRRK2/KDR	6
BP	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	5/365	11/18862	1.1084223692323e-06	7.86108764303778e-06	3.02124539666657e-06	ATF6/CEBPB/ATF4/DDIT3/ATF3	5
BP	GO:0036473	cell death in response to oxidative stress	11/365	89/18862	1.16182811747076e-06	8.21757887411073e-06	3.15825538049305e-06	BCL2/PARP1/PINK1/TXN/ATF4/HSPB1/GATA4/LRRK2/MMP3/SOD2/IL10	11
BP	GO:0097306	cellular response to alcohol	11/365	89/18862	1.16182811747076e-06	8.21757887411073e-06	3.15825538049305e-06	KLF4/CYBB/DNMT3A/DAG1/CTNNB1/PPARG/BRCA1/CFTR/GRAMD1B/AHR/SOD2	11
BP	GO:0042306	regulation of protein import into nucleus	9/365	56/18862	1.17127055319215e-06	8.26203514205888e-06	3.17534122166292e-06	PIK3R2/GLI3/HSP90AB1/TARDBP/MAPK1/LEP/BMP4/IFNG/SHH	9
BP	GO:0051353	positive regulation of oxidoreductase activity	9/365	56/18862	1.17127055319215e-06	8.26203514205888e-06	3.17534122166292e-06	EDN1/ATP7A/SNCA/AGTR1/APOE/TERT/IFNG/AGT/GDNF	9
BP	GO:0086003	cardiac muscle cell contraction	10/365	72/18862	1.20216875662138e-06	8.46857506346744e-06	3.2547205410547e-06	NEDD4L/ATP1A1/GJA1/GATA4/ANK2/KCNQ1/RYR2/CAV1/KCNH2/SCN5A	10
BP	GO:0008542	visual learning	8/365	42/18862	1.21007406849789e-06	8.49804061481351e-06	3.26604501235014e-06	NF1/MTOR/MECP2/GRIN1/KIT/APP/GRIN2A/DBH	8
BP	GO:0033673	negative regulation of kinase activity	19/365	267/18862	1.210763309895e-06	8.49804061481351e-06	3.26604501235014e-06	NPPA/PTPRC/IGF1R/DNAJC3/NF1/SORL1/HSPB1/GADD45A/SNCA/APOE/CDKN1A/BMP4/IFNG/AGT/SOCS1/ADIPOQ/CAV1/CDKN2A/UCHL1	19
BP	GO:0032611	interleukin-1 beta production	12/365	108/18862	1.21122244911175e-06	8.49804061481351e-06	3.26604501235014e-06	P2RX7/HSPB1/HMGB1/AGER/IL6/GHRL/APP/NLRP3/IFNG/IGF1/LPL/EGR1	12
BP	GO:0061337	cardiac conduction	14/365	149/18862	1.23450516093196e-06	8.64979921327695e-06	3.32437027061365e-06	NPPA/ATP1A1/GJA1/ANK2/DMPK/ITPR1/KCNQ1/AGT/RYR2/CASQ2/CAV1/KCNH2/SCN5A/NOS1	14
BP	GO:0071897	DNA biosynthetic process	16/365	194/18862	1.24866816088185e-06	8.73733844125082e-06	3.35801415064061e-06	KLF4/RPS27A/HSP90AA1/HSP90AB1/HNRNPA1/GJA1/MAPK1/ATM/MAPK3/PPARG/SRC/CDKN1A/TERT/PDGFRB/MYC/ADIPOQ	16
BP	GO:0042445	hormone metabolic process	17/365	218/18862	1.26916296582711e-06	8.86889047148079e-06	3.40857343503002e-06	SPP1/CYP3A5/ATP1A1/STUB1/CYP2D6/NGF/LEP/FURIN/CYP19A1/TTR/CYP1A1/GHR/CYP17A1/MME/EGR1/BMP2/SHH	17
BP	GO:0003073	regulation of systemic arterial blood pressure	11/365	90/18862	1.30097075607111e-06	9.06695198039442e-06	3.48469425306875e-06	NPPA/EDN1/MECP2/HSD11B2/GJA1/AGTR1/ADRB2/AR/AGT/SOD2/MME	11
BP	GO:0070301	cellular response to hydrogen peroxide	11/365	90/18862	1.30097075607111e-06	9.06695198039442e-06	3.48469425306875e-06	KLF4/MAP1LC3A/PINK1/TXN/SETX/ETS1/SRC/LRRK2/IL6/IL10/NQO1	11
BP	GO:0051968	positive regulation of synaptic transmission, glutamatergic	7/365	30/18862	1.33074820519759e-06	9.24984874635353e-06	3.55498681782708e-06	STXBP1/EGFR/NLGN3/CCL2/NTRK1/NRXN1/RELN	7
BP	GO:0090183	regulation of kidney development	7/365	30/18862	1.33074820519759e-06	9.24984874635353e-06	3.55498681782708e-06	STAT1/BMP4/MYC/AGT/GDNF/ADIPOQ/VEGFA	7
BP	GO:1901888	regulation of cell junction assembly	16/365	195/18862	1.33667373772165e-06	9.26121279342846e-06	3.55935435276266e-06	OCLN/MEF2C/GJA1/SNCA/SRC/KDR/NLGN3/TLR2/GHRL/APP/IL1RAPL1/AGT/VEGFA/NTRK1/CAV1/NRXN1	16
BP	GO:1902806	regulation of cell cycle G1/S phase transition	16/365	195/18862	1.33667373772165e-06	9.26121279342846e-06	3.55935435276266e-06	KLF4/BCL2/EP300/PRKDC/GADD45A/ATM/EGFR/CCND1/CDKN1A/CCL2/BAX/TERT/AURKA/CYP1A1/GJC2/CDKN2A	16
BP	GO:0030301	cholesterol transport	12/365	109/18862	1.33769141609322e-06	9.26121279342846e-06	3.55935435276266e-06	CEL/NFKBIA/CETP/CFTR/LEP/FURIN/APOE/ABCA1/CLU/ADIPOQ/CAV1/SHH	12
BP	GO:0032757	positive regulation of interleukin-8 production	9/365	57/18862	1.36739984340005e-06	9.44191395825312e-06	3.62880308392931e-06	CD14/DDIT3/HMGB1/IL6/HSPA1B/HSPA1A/TLR2/SERPINE1/ADIPOQ	9
BP	GO:0034205	amyloid-beta formation	9/365	57/18862	1.36739984340005e-06	9.44191395825312e-06	3.62880308392931e-06	PSEN2/SP1/RTN4/SORL1/APOE/IFNG/IGF1/CLU/ADAM10	9
BP	GO:0090596	sensory organ morphogenesis	18/365	244/18862	1.3826180989298e-06	9.53441782582155e-06	3.66435501983891e-06	COL2A1/EDN1/BCL2/GLI3/NF1/ATF4/MFSD2A/MAPK1/MAPK3/CHD7/FASLG/FGFR2/DLX5/BMP4/BAX/VEGFA/FBN1/FOXG1	18
BP	GO:0002690	positive regulation of leukocyte chemotaxis	11/365	91/18862	1.45455429844587e-06	1.00172857869285e-05	3.8499352691552e-06	CCL5/EDN1/MAPK1/MAPK3/HMGB1/IL6/CXCL12/THBS4/SERPINE1/VEGFA/ADAM10	11
BP	GO:0035094	response to nicotine	8/365	43/18862	1.46179100774679e-06	1.00275414607427e-05	3.85387682390028e-06	EDN1/BCL2/MAPK1/PPARA/VCAM1/B2M/CNR1/NTRK1	8
BP	GO:0045454	cell redox homeostasis	8/365	43/18862	1.46179100774679e-06	1.00275414607427e-05	3.85387682390028e-06	CYBB/TXN/DDIT3/PRDX1/NOS2/NOS1/NQO1/MPO	8
BP	GO:2000273	positive regulation of signaling receptor activity	8/365	43/18862	1.46179100774679e-06	1.00275414607427e-05	3.85387682390028e-06	EDN1/PINK1/ADRB2/NLGN3/CCL2/IFNG/RELN/IL10	8
BP	GO:0008016	regulation of heart contraction	18/365	245/18862	1.4662849095659e-06	1.00452031631779e-05	3.86066473157955e-06	NPPA/EDN1/ATP1A1/HDAC4/GJA1/GATA4/ANK2/PIK3CG/DMPK/ITPR1/KCNQ1/AGT/RYR2/CASQ2/CAV1/KCNH2/SCN5A/NOS1	18
BP	GO:0010042	response to manganese ion	6/365	20/18862	1.55303076419815e-06	1.05978657363926e-05	4.0730690871923e-06	ATP7A/ATP13A2/ATF4/LRRK2/APP/SOD2	6
BP	GO:0051767	nitric-oxide synthase biosynthetic process	6/365	20/18862	1.55303076419815e-06	1.05978657363926e-05	4.0730690871923e-06	EDN1/LRRK2/KDR/CCL2/TLR2/IFNG	6
BP	GO:0051769	regulation of nitric-oxide synthase biosynthetic process	6/365	20/18862	1.55303076419815e-06	1.05978657363926e-05	4.0730690871923e-06	EDN1/LRRK2/KDR/CCL2/TLR2/IFNG	6
BP	GO:0071260	cellular response to mechanical stimulus	10/365	74/18862	1.55634047091223e-06	1.06066224280659e-05	4.07643453935481e-06	DAG1/ATP1A1/TNFRSF1A/HDAC4/GJA1/GADD45A/MAPK3/EGFR/SLC2A1/FAS	10
BP	GO:0031663	lipopolysaccharide-mediated signaling pathway	9/365	58/18862	1.59123109613636e-06	1.08162383859451e-05	4.1569960693323e-06	CCL5/NFKBIA/MAPK1/IL18/CD14/MAPK3/PRKCA/CCL2/TLR2	9
BP	GO:0060675	ureteric bud morphogenesis	9/365	58/18862	1.59123109613636e-06	1.08162383859451e-05	4.1569960693323e-06	BCL2/GLI3/BMP4/MYC/AGT/GDNF/VEGFA/BMP2/SHH	9
BP	GO:0061041	regulation of wound healing	13/365	131/18862	1.6005368934072e-06	1.08653827497967e-05	4.17588368257377e-06	XBP1/OCLN/EDN1/PLAT/HRAS/MTOR/GJA1/HMGB1/CXCR4/APOE/SERPINE1/CAV1/PROC	13
BP	GO:0055017	cardiac muscle tissue growth	11/365	92/18862	1.62384477679232e-06	1.10093310385117e-05	4.23120721086737e-06	EDN1/MEF2C/MTOR/GJA1/MAPK1/GATA4/PPARA/NOTCH1/FGFR2/IGF1/ERBB4	11
BP	GO:0014902	myotube differentiation	12/365	111/18862	1.62617309088716e-06	1.10108537615827e-05	4.23179243778221e-06	XBP1/SORT1/BCL2/MEF2C/MTOR/HDAC4/DMPK/NOTCH1/IGF1/GDF15/NOS1/SHH	12
BP	GO:0003002	regionalization	21/365	326/18862	1.6709928926993e-06	1.12997116284084e-05	4.3428089459382e-06	LRP2/EDN1/MEF2C/EP300/PRKDC/GLI3/MED12/GATA4/ATM/DDIT3/NOTCH1/AR/FGFR2/BMP4/GDNF/AURKA/C3/FOXG1/RELN/BMP2/SHH	21
BP	GO:0010644	cell communication by electrical coupling	7/365	31/18862	1.69047765085014e-06	1.13873359389313e-05	4.37648552567178e-06	ATP1A1/GJA1/ANK3/RYR2/CASQ2/GJC2/CAV1	7
BP	GO:0034405	response to fluid shear stress	7/365	31/18862	1.69047765085014e-06	1.13873359389313e-05	4.37648552567178e-06	KLF4/MEF2C/GJA1/ETS1/SRC/ABCA1/PDGFRB	7
BP	GO:0048730	epidermis morphogenesis	7/365	31/18862	1.69047765085014e-06	1.13873359389313e-05	4.37648552567178e-06	KLF4/BCL2/ATP7A/NOTCH1/FGFR2/NGFR/SHH	7
BP	GO:0046661	male sex differentiation	14/365	153/18862	1.69691781208838e-06	1.1416025486466e-05	4.38751175605587e-06	LRP2/BCL2/NUPR1/ICAM1/GATA4/BCL2L11/CCND1/KITLG/AR/KIT/BAX/PDGFRB/NTRK1/SHH	14
BP	GO:0060421	positive regulation of heart growth	8/365	44/18862	1.75674929413255e-06	1.17882382121663e-05	4.53056396907867e-06	EDN1/MEF2C/MTOR/MAPK1/NOTCH1/FGFR2/IGF1/ERBB4	8
BP	GO:0098815	modulation of excitatory postsynaptic potential	8/365	44/18862	1.75674929413255e-06	1.17882382121663e-05	4.53056396907867e-06	ADRB2/DMPK/LRRK2/NLGN3/GRIN1/APP/NRXN1/RELN	8
BP	GO:0051591	response to cAMP	11/365	93/18862	1.81019827116515e-06	1.2115828326443e-05	4.65646641027945e-06	NDUFS4/PIK3CG/CFTR/FOS/AHR/JUN/STAT1/KCNQ1/APP/ADIPOQ/NOX4	11
BP	GO:1902882	regulation of response to oxidative stress	11/365	93/18862	1.81019827116515e-06	1.2115828326443e-05	4.65646641027945e-06	ABCD1/PARP1/PINK1/TXN/ATF4/HSPB1/GATA4/LRRK2/MMP3/SOD2/IL10	11
BP	GO:0030509	BMP signaling pathway	14/365	154/18862	1.83435803893488e-06	1.22618518209261e-05	4.71258750071191e-06	LRP2/USP9X/XIAP/SORL1/GATA4/MAPK3/PPARG/NOTCH1/DLX5/BMP4/GDF15/FBN1/EGR1/BMP2	14
BP	GO:0016485	protein processing	17/365	224/18862	1.84470856218308e-06	1.22766876915984e-05	4.71828935877653e-06	PLAT/PARP1/PSEN2/GLI3/CLN3/NGF/CASP4/SRC/SPG7/FURIN/LRRK2/SERPINE1/ADAM10/MME/GRIN2A/HP/SHH	17
BP	GO:0072171	mesonephric tubule morphogenesis	9/365	59/18862	1.84595972741458e-06	1.22766876915984e-05	4.71828935877653e-06	BCL2/GLI3/BMP4/MYC/AGT/GDNF/VEGFA/BMP2/SHH	9
BP	GO:1903779	regulation of cardiac conduction	9/365	59/18862	1.84595972741458e-06	1.22766876915984e-05	4.71828935877653e-06	NPPA/ATP1A1/ANK2/DMPK/ITPR1/AGT/RYR2/CASQ2/NOS1	9
BP	GO:1904589	regulation of protein import	9/365	59/18862	1.84595972741458e-06	1.22766876915984e-05	4.71828935877653e-06	PIK3R2/GLI3/HSP90AB1/TARDBP/MAPK1/LEP/BMP4/IFNG/SHH	9
BP	GO:0002822	regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	14/365	155/18862	1.98165365396743e-06	1.31624051076974e-05	5.05869641027487e-06	PTPRC/CD4/MEF2C/IL18/IL1R1/HMGB1/AGER/B2M/IL6/HLA-DRB1/NLRP3/PLA2G4A/C3/IL10	14
BP	GO:0086001	cardiac muscle cell action potential	10/365	76/18862	1.99816350071738e-06	1.32552443127437e-05	5.09437722616357e-06	NEDD4L/ATP1A1/GJA1/ANK2/ANK3/KCNQ1/RYR2/CAV1/KCNH2/SCN5A	10
BP	GO:0030336	negative regulation of cell migration	21/365	330/18862	2.02846829897258e-06	1.34392444010411e-05	5.16509382989555e-06	KLF4/GNRH1/MIF/BCL2/MEF2C/DAG1/NF1/MECP2/GJA1/GADD45A/PPARG/HMGB1/APOE/NOTCH1/CXCL12/CCL2/SERPINE1/ADIPOQ/IL24/SHH/ERBB4	21
BP	GO:0090068	positive regulation of cell cycle process	20/365	303/18862	2.03968520003929e-06	1.34964757737113e-05	5.18708951663461e-06	EDN1/EP300/MECP2/BRD4/DYNC1H1/RAD21/GADD45A/ATM/BRCA1/SPAST/EGFR/CCND1/CDKN1A/BAX/APP/TERT/IGF1/PDGFRB/AURKA/CYP1A1	20
BP	GO:0021953	central nervous system neuron differentiation	15/365	178/18862	2.05253064591646e-06	1.35643250009176e-05	5.21316595473998e-06	CTNNB1/ATP7A/GLI3/HSP90AA1/HSP90AB1/RORA/LEP/B2M/FGFR2/DLX5/SATB2/FOXG1/SHH/ERBB4/NPY	15
BP	GO:0008584	male gonad development	13/365	134/18862	2.0684285823444e-06	1.36521503152467e-05	5.24691978610228e-06	LRP2/BCL2/NUPR1/ICAM1/GATA4/BCL2L11/CCND1/KITLG/AR/KIT/BAX/PDGFRB/NTRK1	13
BP	GO:0032869	cellular response to insulin stimulus	17/365	226/18862	2.08344755172093e-06	1.37339603094551e-05	5.27836175439309e-06	XBP1/PIK3R2/IGF1R/PARP1/PRKDC/GSK3B/SP1/SORL1/PPARG/SRC/UCP2/LEP/BGLAP/LPL/SLC2A4/SOCS1/ADIPOQ	17
BP	GO:0048562	embryonic organ morphogenesis	19/365	277/18862	2.09251054421207e-06	1.37763524382465e-05	5.29465428664584e-06	COL2A1/EDN1/MEF2C/CTNNB1/GLI3/MED12/MAPK1/GATA4/MAPK3/CHD7/NOTCH1/FGFR2/DLX5/BMP4/SATB2/RYR2/FBN1/FOXG1/SHH	19
BP	GO:0007179	transforming growth factor beta receptor signaling pathway	16/365	202/18862	2.12644119405256e-06	1.39577395887982e-05	5.36436666214696e-06	RPS27A/PARP1/STUB1/USP9X/EP300/HSP90AB1/CREBBP/PPARA/SRC/FOS/FURIN/JUN/HSPA1A/GDF15/FBN1/CAV1	16
BP	GO:0038128	ERBB2 signaling pathway	7/365	32/18862	2.12806193959896e-06	1.39577395887982e-05	5.36436666214696e-06	STUB1/HSP90AA1/SRC/EGFR/PRKCA/NRG1/ERBB4	7
BP	GO:0051385	response to mineralocorticoid	7/365	32/18862	2.12806193959896e-06	1.39577395887982e-05	5.36436666214696e-06	CYBB/EDN1/PARP1/SRC/FOS/CCND1/CDKN1A	7
BP	GO:0002052	positive regulation of neuroblast proliferation	6/365	21/18862	2.1389136516058e-06	1.39938425656309e-05	5.37824208976142e-06	CTNNB1/GLI3/NOTCH1/VEGFA/FOXG1/SHH	6
BP	GO:0002320	lymphoid progenitor cell differentiation	6/365	21/18862	2.1389136516058e-06	1.39938425656309e-05	5.37824208976142e-06	BCL2/PRKDC/NOTCH1/BMP4/KIT/SHH	6
BP	GO:0090316	positive regulation of intracellular protein transport	15/365	179/18862	2.20146905442708e-06	1.43851298762438e-05	5.52862522243268e-06	PIK3R2/BCL2/HRAS/PINK1/GLI3/HSP90AB1/GSK3B/TARDBP/HUWE1/SORL1/MAPK1/LEP/ANK3/IFNG/SHH	15
BP	GO:0001508	action potential	13/365	135/18862	2.24940794555535e-06	1.46435338147222e-05	5.62793739716715e-06	NEDD4L/ATP1A1/CLN3/GJA1/ANK2/ANK3/KCNQ1/RYR2/CNR1/KCNA2/CAV1/KCNH2/SCN5A	13
BP	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	13/365	135/18862	2.24940794555535e-06	1.46435338147222e-05	5.62793739716715e-06	SNCA/NGF/PPARG/BCL2L11/HMGB1/FAS/FASLG/CTSD/NGFR/BAX/NLRP3/MYC/XDH	13
BP	GO:0046546	development of primary male sexual characteristics	13/365	135/18862	2.24940794555535e-06	1.46435338147222e-05	5.62793739716715e-06	LRP2/BCL2/NUPR1/ICAM1/GATA4/BCL2L11/CCND1/KITLG/AR/KIT/BAX/PDGFRB/NTRK1	13
BP	GO:0051057	positive regulation of small GTPase mediated signal transduction	10/365	77/18862	2.25737013598787e-06	1.46589023470974e-05	5.63384397266922e-06	HRAS/NGF/SRC/PIK3CG/NOTCH1/KITLG/IGF1/PDGFRB/NTRK1/RELN	10
BP	GO:0060420	regulation of heart growth	10/365	77/18862	2.25737013598787e-06	1.46589023470974e-05	5.63384397266922e-06	EDN1/MEF2C/MTOR/GJA1/MAPK1/PPARA/NOTCH1/FGFR2/IGF1/ERBB4	10
BP	GO:0046890	regulation of lipid biosynthetic process	16/365	203/18862	2.26833418236353e-06	1.47118477205585e-05	5.65419242483103e-06	ABCD1/ATP1A1/MTOR/SP1/MFSD2A/TNFRSF1A/PPARA/BRCA1/LEP/APOE/IFNG/ADIPOQ/HTR2C/EGR1/C3/BMP2	16
BP	GO:0060538	skeletal muscle organ development	14/365	157/18862	2.30829380226218e-06	1.49524873280201e-05	5.74667724872723e-06	BCL2/MEF2C/DAG1/ARNTL/NUPR1/EP300/HDAC4/ATF3/FOS/NOTCH1/ELN/EGR1/CAV1/SHH	14
BP	GO:0060070	canonical Wnt signaling pathway	21/365	333/18862	2.34086409156928e-06	1.51447251610304e-05	5.82055985816002e-06	KLF4/ARNTL/CTNNB1/GLI3/MED12/XIAP/GSK3B/SRC/DDIT3/SOX2/EGFR/LRRK2/APOE/NOTCH1/FGFR2/DLX5/CDH2/EGR1/CAV1/BMP2/SHH	21
BP	GO:0033559	unsaturated fatty acid metabolic process	12/365	115/18862	2.37261748813031e-06	1.53123057125451e-05	5.8849659547239e-06	ABCD1/EDN1/MIF/PTGS1/TNFRSF1A/CYP2D6/CYP2U1/CYP2E1/MAPK3/GSTM1/PLA2G4A/CYP1A1	12
BP	GO:1990748	cellular detoxification	12/365	115/18862	2.37261748813031e-06	1.53123057125451e-05	5.8849659547239e-06	HBA1/PTGS1/ATP7A/TXN/APOE/PRDX1/HBB/GSTM1/SOD2/HP/NQO1/MPO	12
BP	GO:0030888	regulation of B cell proliferation	9/365	61/18862	2.46233499815603e-06	1.58327535385119e-05	6.08498924282448e-06	PTPRC/MIF/BCL2/MEF2C/ATM/CTLA4/AHR/CDKN1A/IL10	9
BP	GO:0031060	regulation of histone methylation	9/365	61/18862	2.46233499815603e-06	1.58327535385119e-05	6.08498924282448e-06	CTNNB1/NSD1/MECP2/KMT2A/BRD4/DNMT1/BRCA1/MTHFR/TET1	9
BP	GO:0046824	positive regulation of nucleocytoplasmic transport	9/365	61/18862	2.46233499815603e-06	1.58327535385119e-05	6.08498924282448e-06	PIK3R2/GLI3/HSP90AB1/GSK3B/TARDBP/MAPK1/LEP/IFNG/SHH	9
BP	GO:0042100	B cell proliferation	11/365	96/18862	2.48665078177969e-06	1.59694848979569e-05	6.13753909458314e-06	PTPRC/MIF/BCL2/MEF2C/ATM/CTLA4/AHR/CDKN1A/BAX/CD40LG/IL10	11
BP	GO:0007595	lactation	8/365	46/18862	2.50062000955741e-06	1.60002996699554e-05	6.14938211075051e-06	XBP1/ATP7A/CCND1/PRL/VEGFA/CAV1/XDH/ERBB4	8
BP	GO:0045981	positive regulation of nucleotide metabolic process	8/365	46/18862	2.50062000955741e-06	1.60002996699554e-05	6.14938211075051e-06	PINK1/P2RX7/PPARA/APP/IFNG/IGF1/NOS2/NOS1	8
BP	GO:1900544	positive regulation of purine nucleotide metabolic process	8/365	46/18862	2.50062000955741e-06	1.60002996699554e-05	6.14938211075051e-06	PINK1/P2RX7/PPARA/APP/IFNG/IGF1/NOS2/NOS1	8
BP	GO:0050886	endocrine process	10/365	78/18862	2.54533669893603e-06	1.62665351431394e-05	6.25170417282534e-06	EDN1/HSD11B2/GJA1/AGTR1/LEP/GHRL/AGT/POMC/CRHR1/MME	10
BP	GO:0001701	in utero embryonic development	21/365	335/18862	2.57282461254101e-06	1.64221512463898e-05	6.31151198275466e-06	KLF4/EDN1/ATP7A/CEBPB/GLI3/RTN4/MAPK1/CHD7/BCL2L11/FURIN/BRCA2/NOTCH1/AR/FGFR2/TET1/KRT8/IGF1/VEGFA/ADAM10/BMP2/IL10	21
BP	GO:0030111	regulation of Wnt signaling pathway	22/365	365/18862	2.81896637839477e-06	1.79713398593401e-05	6.90691037773241e-06	ARNTL/CTNNB1/GLI3/XIAP/GSK3B/SRC/DDIT3/SOX2/EGFR/LRRK2/APOE/NOTCH1/FGFR2/DLX5/TLR2/APP/TERT/CDH2/EGR1/CAV1/BMP2/SHH	22
BP	GO:0015844	monoamine transport	10/365	79/18862	2.86471195471074e-06	1.8229548529608e-05	7.00614750519496e-06	PINK1/SNCA/CXCL12/DRD4/GDNF/CNR1/KCNA2/P2RY12/NOS1/SLC6A4	10
BP	GO:0032102	negative regulation of response to external stimulus	23/365	394/18862	2.86643455098727e-06	1.8229548529608e-05	7.00614750519496e-06	SPP1/KLF4/PTPRC/EDN1/PLAT/MIF/RORA/TNFRSF1A/GJA1/PPARA/PPARG/LEP/APOE/NOTCH1/CCL2/GHRL/HLA-DRB1/NLRP3/IGF1/SERPINE1/ADIPOQ/IL10/PROC	23
BP	GO:1903038	negative regulation of leukocyte cell-cell adhesion	13/365	138/18862	2.87961548116458e-06	1.824479585425e-05	7.01200749702789e-06	KLF4/GNRH1/CEBPB/GLI3/PPARA/HMGB1/CTLA4/CXCL12/BMP4/HLA-DRB1/SOCS1/SHH/IL10	13
BP	GO:0031214	biomineral tissue development	14/365	160/18862	2.88855417405835e-06	1.824479585425e-05	7.01200749702789e-06	SPP1/MEF2C/CEBPB/ATF4/P2RX7/PPARA/ADRB2/LEP/NOTCH1/FGFR2/BGLAP/BMP4/IGF1/BMP2	14
BP	GO:0050728	negative regulation of inflammatory response	14/365	160/18862	2.88855417405835e-06	1.824479585425e-05	7.01200749702789e-06	KLF4/PTPRC/RORA/TNFRSF1A/PPARA/PPARG/APOE/GHRL/HLA-DRB1/NLRP3/IGF1/ADIPOQ/IL10/PROC	14
BP	GO:0010888	negative regulation of lipid storage	6/365	22/18862	2.89323281601596e-06	1.824479585425e-05	7.01200749702789e-06	NFKBIA/PPARA/PPARG/LEP/IL6/ABCA1	6
BP	GO:0048714	positive regulation of oligodendrocyte differentiation	6/365	22/18862	2.89323281601596e-06	1.824479585425e-05	7.01200749702789e-06	DAG1/MTOR/PPARG/CXCR4/TLR2/SHH	6
BP	GO:0051882	mitochondrial depolarization	6/365	22/18862	2.89323281601596e-06	1.824479585425e-05	7.01200749702789e-06	ABCD1/BCL2/PARP1/SRC/LRRK2/KDR	6
BP	GO:0055093	response to hyperoxia	6/365	22/18862	2.89323281601596e-06	1.824479585425e-05	7.01200749702789e-06	PPARG/FAS/CDKN1A/PDGFRB/CYP1A1/CAV1	6
BP	GO:0007632	visual behavior	8/365	47/18862	2.96319018834619e-06	1.85963278726666e-05	7.14711151070248e-06	NF1/MTOR/MECP2/GRIN1/KIT/APP/GRIN2A/DBH	8
BP	GO:0030857	negative regulation of epithelial cell differentiation	8/365	47/18862	2.96319018834619e-06	1.85963278726666e-05	7.14711151070248e-06	MMP9/CCND1/NOTCH1/STAT1/IFNG/VEGFA/CAV1/XDH	8
BP	GO:0051972	regulation of telomerase activity	8/365	47/18862	2.96319018834619e-06	1.85963278726666e-05	7.14711151070248e-06	KLF4/HSP90AA1/HSP90AB1/MAPK1/MAPK3/PPARG/SRC/MYC	8
BP	GO:1903053	regulation of extracellular matrix organization	8/365	47/18862	2.96319018834619e-06	1.85963278726666e-05	7.14711151070248e-06	DAG1/TNFRSF1A/ETS1/CST3/IL6/NOTCH1/AGT/BMP2	8
BP	GO:0048070	regulation of developmental pigmentation	5/365	13/18862	2.99054686907008e-06	1.87455357038477e-05	7.2044564346586e-06	BCL2/ZEB2/BCL2L11/KITLG/BAX	5
BP	GO:0031341	regulation of cell killing	11/365	98/18862	3.05229840368898e-06	1.91097246948661e-05	7.34442489228108e-06	PTPRC/HSP90AB1/P2RX7/ICAM1/BCL2L11/AGER/LEP/B2M/HLA-DRB1/IFNG/NOS2	11
BP	GO:0099173	postsynapse organization	14/365	161/18862	3.1090151120147e-06	1.94415592548207e-05	7.47195859782444e-06	CEL/IGF1R/CDKL5/LRRK2/APOE/NLGN3/GHRL/IL1RAPL1/GDNF/CDH2/ADAM10/GRIN2B/NRXN1/RELN	14
BP	GO:0003014	renal system process	12/365	118/18862	3.11653725962573e-06	1.94421406637439e-05	7.47218205024124e-06	EDNRB/EDN1/BCL2/CLN3/HSD11B2/GJA1/AGTR1/HBB/BMP4/KCNQ1/AGT/ADIPOQ	12
BP	GO:0042752	regulation of circadian rhythm	12/365	118/18862	3.11653725962573e-06	1.94421406637439e-05	7.47218205024124e-06	ARNTL/USP9X/CLOCK/PRKDC/MTOR/GSK3B/TARDBP/RORA/PPARA/PPARG/GHRL/DRD4	12
BP	GO:2000378	negative regulation of reactive oxygen species metabolic process	9/365	63/18862	3.24811731828356e-06	2.02388643379716e-05	7.77838620957379e-06	ABCD1/BCL2/PINK1/PPARA/BRCA1/MMP3/CAV1/HP/IL10	9
BP	GO:0044060	regulation of endocrine process	7/365	34/18862	3.28984218594037e-06	2.04501591463324e-05	7.85959297078641e-06	GJA1/AGTR1/LEP/GHRL/AGT/POMC/CRHR1	7
BP	GO:0050931	pigment cell differentiation	7/365	34/18862	3.28984218594037e-06	2.04501591463324e-05	7.85959297078641e-06	EDNRB/BCL2/MEF2C/ZEB2/GLI3/KITLG/KIT	7
BP	GO:0009749	response to glucose	15/365	185/18862	3.3167498796163e-06	2.05929642584955e-05	7.91447714296903e-06	XBP1/IGF1R/GJA1/ICAM1/GATA4/CFTR/UCP2/AGER/PLA2G6/TXNIP/GHRL/HLA-DRB1/LPL/ADIPOQ/EGR1	15
BP	GO:0016358	dendrite development	17/365	234/18862	3.34271637015122e-06	2.07151162845243e-05	7.96142373141725e-06	MEF2C/NEDD4L/MTOR/MECP2/GSK3B/CUX1/MFSD2A/CDKL5/LRRK2/APOE/GHRL/APP/ACSL4/IL1RAPL1/ADAM10/CAMK2A/RELN	17
BP	GO:0110148	biomineralization	14/365	162/18862	3.34433956064636e-06	2.07151162845243e-05	7.96142373141725e-06	SPP1/MEF2C/CEBPB/ATF4/P2RX7/PPARA/ADRB2/LEP/NOTCH1/FGFR2/BGLAP/BMP4/IGF1/BMP2	14
BP	GO:0044728	DNA methylation or demethylation	11/365	99/18862	3.37517842322514e-06	2.08814230108279e-05	8.02534025977759e-06	DNMT3A/PARP1/USP9X/MECP2/KMT2A/DNMT1/BRCA1/FOS/TET1/MYC/CYP1A1	11
BP	GO:0010906	regulation of glucose metabolic process	12/365	119/18862	3.40658502319197e-06	2.10260212398429e-05	8.08091357909614e-06	EP300/MTOR/GSK3B/RORA/PPARA/SRC/HMGB1/LEP/LEPR/IGF1/ADIPOQ/POMC	12
BP	GO:0120254	olefinic compound metabolic process	12/365	119/18862	3.40658502319197e-06	2.10260212398429e-05	8.08091357909614e-06	ABCD1/PTGS1/CYP2D6/CYP2U1/CYP2E1/MAPK3/GRIN1/PLA2G4A/CYP1A1/CYP17A1/EGR1/BMP2	12
BP	GO:0002067	glandular epithelial cell differentiation	8/365	48/18862	3.49639727966154e-06	2.15042812711498e-05	8.26472286651395e-06	ARNTL/CLOCK/GSK3B/NOTCH1/FGFR2/BMP4/CDH2/BMP2	8
BP	GO:0002673	regulation of acute inflammatory response	8/365	48/18862	3.49639727966154e-06	2.15042812711498e-05	8.26472286651395e-06	EDNRB/PPARG/PIK3CG/IL6/NLRP3/TNFSF11/CNR1/C3	8
BP	GO:0035850	epithelial cell differentiation involved in kidney development	8/365	48/18862	3.49639727966154e-06	2.15042812711498e-05	8.26472286651395e-06	MMP9/MEF2C/CTNNB1/NOTCH1/STAT1/BMP4/GDNF/ADIPOQ	8
BP	GO:0060828	regulation of canonical Wnt signaling pathway	19/365	287/18862	3.52193398154412e-06	2.16359183795797e-05	8.3153148489385e-06	ARNTL/CTNNB1/GLI3/XIAP/GSK3B/SRC/DDIT3/SOX2/EGFR/LRRK2/APOE/NOTCH1/FGFR2/DLX5/CDH2/EGR1/CAV1/BMP2/SHH	19
BP	GO:0043367	CD4-positive, alpha-beta T cell differentiation	10/365	81/18862	3.60925754273446e-06	2.21463704322065e-05	8.51149646963108e-06	ATP7A/MTOR/RORA/IL18/HMGB1/IL6/HLA-DRB1/NLRP3/IFNG/SOCS1	10
BP	GO:0044262	cellular carbohydrate metabolic process	19/365	288/18862	3.70503677166851e-06	2.27074501907646e-05	8.72713579521573e-06	NUPR1/EP300/SCARB2/MTOR/MECP2/GSK3B/RORA/HDAC4/SNCA/PPARA/SRC/HMGB1/SLC2A1/LEP/LEPR/IGF1/PLA2G4A/ADIPOQ/POMC	19
BP	GO:0006805	xenobiotic metabolic process	12/365	120/18862	3.72015563338816e-06	2.27125187904858e-05	8.72908380600896e-06	CYP3A5/PTGS1/HSP90AB1/RORA/CYP2D6/CYP2U1/CYP2E1/AHR/GRIN1/GSTM1/CYP1A1/NQO1	12
BP	GO:0010508	positive regulation of autophagy	12/365	120/18862	3.72015563338816e-06	2.27125187904858e-05	8.72908380600896e-06	IKBKG/PINK1/ATF6/HTT/GSK3B/MAPK3/BCL2L11/HMGB1/ADRB2/LRRK2/KDR/IFNG	12
BP	GO:1900542	regulation of purine nucleotide metabolic process	12/365	120/18862	3.72015563338816e-06	2.27125187904858e-05	8.72908380600896e-06	NUPR1/PARP1/PINK1/EP300/P2RX7/HDAC4/PPARA/APP/IFNG/IGF1/NOS2/NOS1	12
BP	GO:0035710	CD4-positive, alpha-beta T cell activation	11/365	100/18862	3.72756087906521e-06	2.27125187904858e-05	8.72908380600896e-06	ATP7A/MTOR/RORA/IL18/HMGB1/AGER/IL6/HLA-DRB1/NLRP3/IFNG/SOCS1	11
BP	GO:0060419	heart growth	11/365	100/18862	3.72756087906521e-06	2.27125187904858e-05	8.72908380600896e-06	EDN1/MEF2C/MTOR/GJA1/MAPK1/GATA4/PPARA/NOTCH1/FGFR2/IGF1/ERBB4	11
BP	GO:0001505	regulation of neurotransmitter levels	16/365	211/18862	3.74751732565925e-06	2.28075647470937e-05	8.76561274092391e-06	MAOA/STXBP1/MEF2C/CLN3/DNAJC5/GSK3B/SNCA/LRRK2/DRD4/GDNF/CNR1/CAMK2A/NOS1/NRXN1/SLC6A4/DBH	16
BP	GO:0006367	transcription initiation from RNA polymerase II promoter	15/365	187/18862	3.78770304398699e-06	2.30253632197769e-05	8.84931905013649e-06	NPPA/MED12/MECP2/CREBBP/RORA/PPARA/PPARG/HMGB1/CCND1/CDKN1A/NOTCH1/AR/BAX/NR4A1/ESR2	15
BP	GO:0032098	regulation of appetite	6/365	23/18862	3.85080929442302e-06	2.33547344693048e-05	8.97590603359442e-06	PPARA/LEP/GHRL/POMC/HTR2C/NPY	6
BP	GO:0035162	embryonic hemopoiesis	6/365	23/18862	3.85080929442302e-06	2.33547344693048e-05	8.97590603359442e-06	ATF4/KMT2A/KDR/KITLG/KIT/VEGFA	6
BP	GO:0006066	alcohol metabolic process	22/365	373/18862	4.00142806139461e-06	2.4240132492291e-05	9.31619033299842e-06	CYP3A5/CEL/MECP2/SP1/CYP2D6/NFE2L1/SNCA/ALDH2/CETP/CFTR/LEP/ALDH3A2/APOE/ABCA1/APP/LEPR/IGF1/TTR/PLA2G4A/CYP1A1/BMP2/DBH	22
BP	GO:0032148	activation of protein kinase B activity	7/365	35/18862	4.04441103256621e-06	2.44439345778886e-05	9.39451742218795e-06	PINK1/TXN/MTOR/IL18/SRC/NRG1/IGF1	7
BP	GO:0086005	ventricular cardiac muscle cell action potential	7/365	35/18862	4.04441103256621e-06	2.44439345778886e-05	9.39451742218795e-06	NEDD4L/ANK2/KCNQ1/RYR2/CAV1/KCNH2/SCN5A	7
BP	GO:2000146	negative regulation of cell motility	21/365	345/18862	4.07833642098582e-06	2.46205453603688e-05	9.46239410004722e-06	KLF4/GNRH1/MIF/BCL2/MEF2C/DAG1/NF1/MECP2/GJA1/GADD45A/PPARG/HMGB1/APOE/NOTCH1/CXCL12/CCL2/SERPINE1/ADIPOQ/IL24/SHH/ERBB4	21
BP	GO:0070231	T cell apoptotic process	8/365	49/18862	4.10879458324131e-06	2.47648876372533e-05	9.5178690494924e-06	CCL5/RPS6/GLI3/BCL2L11/FAS/FASLG/BMP4/BAX	8
BP	GO:0045621	positive regulation of lymphocyte differentiation	11/365	101/18862	4.11170946824095e-06	2.47648876372533e-05	9.5178690494924e-06	XBP1/PTPRC/PRKDC/GLI3/IL18/HLA-DRB1/NLRP3/IFNG/SOCS1/SHH/IL10	11
BP	GO:0050795	regulation of behavior	9/365	65/18862	4.24034238134438e-06	2.55102896827086e-05	9.80434880913384e-06	MEF2C/MTOR/HDAC4/GJA1/APOE/GHRL/LEPR/CNR1/RELN	9
BP	GO:0006606	protein import into nucleus	13/365	143/18862	4.28241460494837e-06	2.5733820944087e-05	9.8902583963458e-06	PIK3R2/NFKBIA/GLI3/HSP90AB1/TARDBP/MAPK1/LEP/LRRK2/CDKN1A/BMP4/TXNIP/IFNG/SHH	13
BP	GO:0002285	lymphocyte activation involved in immune response	15/365	189/18862	4.31752624348541e-06	2.59150600440397e-05	9.95991387168109e-06	XBP1/PTPRC/RPS6/ATP7A/MTOR/RORA/ICAM1/IL18/HMGB1/IL6/HLA-DRB1/NLRP3/IFNG/CD40LG/IL10	15
BP	GO:0006140	regulation of nucleotide metabolic process	12/365	122/18862	4.42443571420059e-06	2.6495991450945e-05	1.01831827650697e-05	NUPR1/PARP1/PINK1/EP300/P2RX7/HDAC4/PPARA/APP/IFNG/IGF1/NOS2/NOS1	12
BP	GO:0019218	regulation of steroid metabolic process	12/365	122/18862	4.42443571420059e-06	2.6495991450945e-05	1.01831827650697e-05	ATP1A1/STUB1/SP1/RORA/AGTR1/LEP/APOE/KIT/IFNG/AGT/EGR1/BMP2	12
BP	GO:0003007	heart morphogenesis	17/365	239/18862	4.44306506643476e-06	2.65771457802509e-05	1.02143727422037e-05	LRP2/COL2A1/MEF2C/CTNNB1/MTOR/RTN4/GATA4/CHD7/NRG1/NOTCH1/ELN/FGFR2/BMP4/RYR2/VEGFA/BMP2/SHH	17
BP	GO:0010507	negative regulation of autophagy	10/365	83/18862	4.51623555380256e-06	2.69532233621467e-05	1.03589103322531e-05	BCL2/NUPR1/PINK1/MTOR/SNCA/GATA4/LEP/LRRK2/LEPR/IL10	10
BP	GO:0060291	long-term synaptic potentiation	10/365	83/18862	4.51623555380256e-06	2.69532233621467e-05	1.03589103322531e-05	MECP2/GSK3B/MAPK1/AGER/APOE/APP/GRIN2B/MME/GRIN2A/RELN	10
BP	GO:0098869	cellular oxidant detoxification	11/365	102/18862	4.53002717968278e-06	2.70047406132798e-05	1.03787099153264e-05	HBA1/PTGS1/ATP7A/TXN/APOE/PRDX1/HBB/SOD2/HP/NQO1/MPO	11
BP	GO:0032310	prostaglandin secretion	5/365	14/18862	4.57820272385324e-06	2.72299012007362e-05	1.04652457000999e-05	EDN1/LEP/TNFSF11/PLA2G4A/NOS2	5
BP	GO:0048569	post-embryonic animal organ development	5/365	14/18862	4.57820272385324e-06	2.72299012007362e-05	1.04652457000999e-05	KLF4/BCL2L11/BAX/VEGFA/FBN1	5
BP	GO:0009746	response to hexose	15/365	190/18862	4.6064727434844e-06	2.73669447666258e-05	1.05179155419065e-05	XBP1/IGF1R/GJA1/ICAM1/GATA4/CFTR/UCP2/AGER/PLA2G6/TXNIP/GHRL/HLA-DRB1/LPL/ADIPOQ/EGR1	15
BP	GO:0040013	negative regulation of locomotion	22/365	377/18862	4.74809615841444e-06	2.81763438697746e-05	1.08289912384891e-05	KLF4/GNRH1/MIF/BCL2/MEF2C/DAG1/NF1/MECP2/GJA1/GADD45A/PPARG/HMGB1/APOE/NOTCH1/CXCL12/CCL2/GHRL/SERPINE1/ADIPOQ/IL24/SHH/ERBB4	22
BP	GO:0022029	telencephalon cell migration	8/365	50/18862	4.80970027296011e-06	2.84451652301392e-05	1.09323071324731e-05	GLI3/RTN4/CXCR4/LRRK2/CXCL12/P2RY12/FOXG1/RELN	8
BP	GO:1903202	negative regulation of oxidative stress-induced cell death	8/365	50/18862	4.80970027296011e-06	2.84451652301392e-05	1.09323071324731e-05	PINK1/TXN/ATF4/HSPB1/GATA4/LRRK2/SOD2/IL10	8
BP	GO:2000179	positive regulation of neural precursor cell proliferation	8/365	50/18862	4.80970027296011e-06	2.84451652301392e-05	1.09323071324731e-05	LRP2/CTNNB1/GLI3/NOTCH1/VEGFA/GJC2/FOXG1/SHH	8
BP	GO:0006690	icosanoid metabolic process	12/365	123/18862	4.81866132929745e-06	2.84659970626895e-05	1.09403134136717e-05	EDN1/MIF/PTGS1/TNFRSF1A/CYP2D6/CYP2U1/CYP2E1/MAPK3/TLR2/GSTM1/PLA2G4A/CYP1A1	12
BP	GO:0002294	CD4-positive, alpha-beta T cell differentiation involved in immune response	9/365	66/18862	4.82708624543422e-06	2.84836182735092e-05	1.09470857592414e-05	ATP7A/MTOR/RORA/IL18/HMGB1/IL6/HLA-DRB1/NLRP3/IFNG	9
BP	GO:0003176	aortic valve development	7/365	36/18862	4.93778064479152e-06	2.89734797027341e-05	1.11353538024506e-05	NPPA/TNFRSF1A/GATA4/NOTCH1/ELN/BMP4/BMP2	7
BP	GO:0030224	monocyte differentiation	7/365	36/18862	4.93778064479152e-06	2.89734797027341e-05	1.11353538024506e-05	CD4/PPARG/JUN/BMP4/HLA-DRB1/MYC/VEGFA	7
BP	GO:0031062	positive regulation of histone methylation	7/365	36/18862	4.93778064479152e-06	2.89734797027341e-05	1.11353538024506e-05	CTNNB1/MECP2/KMT2A/BRD4/DNMT1/BRCA1/TET1	7
BP	GO:0043267	negative regulation of potassium ion transport	7/365	36/18862	4.93778064479152e-06	2.89734797027341e-05	1.11353538024506e-05	NEDD4L/ATF4/ANK3/CASQ2/CAV1/KCNH2/NOS1	7
BP	GO:0071709	membrane assembly	7/365	36/18862	4.93778064479152e-06	2.89734797027341e-05	1.11353538024506e-05	CEL/NLGN3/ANK3/IL1RAPL1/CDH2/CAV1/NRXN1	7
BP	GO:0046822	regulation of nucleocytoplasmic transport	11/365	103/18862	4.98506257603566e-06	2.92181607200119e-05	1.12293918580823e-05	PIK3R2/TXN/GLI3/HSP90AB1/GSK3B/TARDBP/MAPK1/LEP/BMP4/IFNG/SHH	11
BP	GO:0071901	negative regulation of protein serine/threonine kinase activity	13/365	145/18862	4.99449916196937e-06	2.92407255187334e-05	1.12380641687548e-05	NPPA/NF1/SORL1/HSPB1/GADD45A/APOE/CDKN1A/BMP4/AGT/ADIPOQ/CAV1/CDKN2A/UCHL1	13
BP	GO:0042475	odontogenesis of dentin-containing tooth	10/365	84/18862	5.03949082572713e-06	2.94711675774925e-05	1.13266297770827e-05	GLI3/PPARA/BCL2L11/BMP4/NGFR/BAX/SERPINE1/SCN5A/BMP2/SHH	10
BP	GO:0006633	fatty acid biosynthetic process	14/365	168/18862	5.11993619873392e-06	2.99081987323363e-05	1.14945936040655e-05	XBP1/PLP1/ABCD1/EDN1/MIF/PTGS1/CYP2D6/CYP2E1/BRCA1/GSTM1/LPL/PLA2G4A/ADIPOQ/CYP1A1	14
BP	GO:1901990	regulation of mitotic cell cycle phase transition	24/365	439/18862	5.37009824404742e-06	3.13345531876747e-05	1.20427832475205e-05	KLF4/BCL2/EP300/PRKDC/MECP2/HSP90AA1/BRD4/DYNC1H1/RAD21/GADD45A/ATM/BRCA1/ALMS1/EGFR/CCND1/CDKN1A/CCL2/BAX/APP/TERT/AURKA/CYP1A1/GJC2/CDKN2A	24
BP	GO:0016525	negative regulation of angiogenesis	13/365	146/18862	5.3883151123078e-06	3.14058366345423e-05	1.20701795564649e-05	KLF4/AGO1/CTNNB1/GTF2I/MECP2/GADD45A/PPARG/FASLG/STAT1/THBS4/GHRL/PRL/SERPINE1	13
BP	GO:0002287	alpha-beta T cell activation involved in immune response	9/365	67/18862	5.48211441756172e-06	3.18108501790666e-05	1.22258380814103e-05	ATP7A/MTOR/RORA/IL18/HMGB1/IL6/HLA-DRB1/NLRP3/IFNG	9
BP	GO:0002293	alpha-beta T cell differentiation involved in immune response	9/365	67/18862	5.48211441756172e-06	3.18108501790666e-05	1.22258380814103e-05	ATP7A/MTOR/RORA/IL18/HMGB1/IL6/HLA-DRB1/NLRP3/IFNG	9
BP	GO:0050918	positive chemotaxis	9/365	67/18862	5.48211441756172e-06	3.18108501790666e-05	1.22258380814103e-05	CCL5/MIF/HMGB1/AGER/KDR/CXCL12/BMP4/GDNF/VEGFA	9
BP	GO:0072078	nephron tubule morphogenesis	9/365	67/18862	5.48211441756172e-06	3.18108501790666e-05	1.22258380814103e-05	BCL2/GLI3/BMP4/MYC/AGT/GDNF/VEGFA/BMP2/SHH	9
BP	GO:0090287	regulation of cellular response to growth factor stimulus	19/365	296/18862	5.50974348494243e-06	3.19357667776176e-05	1.22738471757591e-05	LRP2/RPS27A/STUB1/EP300/XIAP/HSP90AB1/CREBBP/SORL1/GATA4/PPARA/PPARG/NOTCH1/BMP4/NGFR/HSPA1A/AGT/FBN1/CAV1/XDH	19
BP	GO:0061448	connective tissue development	17/365	243/18862	5.54692786028295e-06	3.21157305538949e-05	1.23430125069873e-05	XBP1/COL2A1/EDN1/MEF2C/ATP7A/GLI3/SORL1/MAPK3/LEP/NOTCH1/BMP4/GHRL/SATB2/PDGFRB/EGR1/TRPV4/BMP2	17
BP	GO:0051271	negative regulation of cellular component movement	21/365	352/18862	5.5676182658904e-06	3.21999049764313e-05	1.23753631940873e-05	KLF4/GNRH1/MIF/BCL2/MEF2C/DAG1/NF1/MECP2/GJA1/GADD45A/PPARG/HMGB1/APOE/NOTCH1/CXCL12/CCL2/SERPINE1/ADIPOQ/IL24/SHH/ERBB4	21
BP	GO:0000186	activation of MAPKK activity	8/365	51/18862	5.60924030577934e-06	3.23560789291133e-05	1.24353854018333e-05	EIF2AK2/MAPK1/NGF/MAPK3/EGFR/LRRK2/BMP4/NTRK1	8
BP	GO:2000677	regulation of transcription regulatory region DNA binding	8/365	51/18862	5.60924030577934e-06	3.23560789291133e-05	1.24353854018333e-05	KLF4/PARP1/CTNNB1/NSD1/EP300/DDIT3/IFNG/IGF1	8
BP	GO:0034109	homotypic cell-cell adhesion	10/365	85/18862	5.61445747284752e-06	3.23560789291133e-05	1.24353854018333e-05	CCL5/STXBP1/HSPB1/PIK3CG/PRKCA/HBB/ANK3/TNFSF11/FN1/P2RY12	10
BP	GO:0006909	phagocytosis	22/365	381/18862	5.61934958856783e-06	3.23560789291133e-05	1.24353854018333e-05	PIK3R2/FCGR3A/PTPRC/CLN3/HSP90AA1/HSP90AB1/MAPK1/CD14/MAPK3/PPARG/SRC/HMGB1/PLA2G6/LEP/C4A/CCL2/TLR2/LEPR/IFNG/ADIPOQ/C3/MBL2	22
BP	GO:0071466	cellular response to xenobiotic stimulus	12/365	125/18862	5.700807991874e-06	3.27890428895258e-05	1.26017860873004e-05	CYP3A5/PTGS1/HSP90AB1/RORA/CYP2D6/CYP2U1/CYP2E1/AHR/GRIN1/GSTM1/CYP1A1/NQO1	12
BP	GO:0030258	lipid modification	18/365	270/18862	5.77505029349453e-06	3.31795974052145e-05	1.27518875854966e-05	CYP3A5/PIK3R2/ABCD1/MTOR/MFSD2A/PPARA/CYP2E1/PPARG/AGTR1/PIK3CG/LEP/ALDH3A2/APOE/AGT/SOCS1/ADIPOQ/CNR1/CYP1A1	18
BP	GO:0007519	skeletal muscle tissue development	13/365	147/18862	5.80932821003013e-06	3.33399384334405e-05	1.28135113219847e-05	BCL2/MEF2C/ARNTL/NUPR1/EP300/HDAC4/ATF3/FOS/NOTCH1/ELN/EGR1/CAV1/SHH	13
BP	GO:0002819	regulation of adaptive immune response	14/365	170/18862	5.8751554534941e-06	3.36807925997679e-05	1.29445115254825e-05	PTPRC/CD4/MEF2C/IL18/IL1R1/HMGB1/AGER/B2M/IL6/HLA-DRB1/NLRP3/PLA2G4A/C3/IL10	14
BP	GO:0032388	positive regulation of intracellular transport	16/365	219/18862	6.04000412074126e-06	3.45501437901199e-05	1.32786285587996e-05	PIK3R2/BCL2/HRAS/PINK1/GLI3/HSP90AB1/GSK3B/TARDBP/DYNC1H1/HUWE1/SORL1/MAPK1/LEP/ANK3/IFNG/SHH	16
BP	GO:0051701	biological process involved in interaction with host	16/365	219/18862	6.04000412074126e-06	3.45501437901199e-05	1.32786285587996e-05	CCR5/CD4/EIF2AK2/DAG1/CTNNB1/SCARB2/VAPB/ICAM1/SRC/BCL2L11/EGFR/CXCR4/HSPA1B/HSPA1A/HLA-DRB1/CAV1	16
BP	GO:0045926	negative regulation of growth	17/365	245/18862	6.18630399643821e-06	3.53483789490804e-05	1.35854136258256e-05	SPP1/BCL2/RAI1/RTN4/GJA1/PPARA/PPARG/ADRB2/CDKN1A/NOTCH1/HSPA1B/BMP4/HSPA1A/GDF15/ESR2/CDKN2A/SLC6A4	17
BP	GO:0010611	regulation of cardiac muscle hypertrophy	9/365	68/18862	6.21187063582435e-06	3.54557588962973e-05	1.36266828732828e-05	EDN1/PARP1/MTOR/TNFRSF1A/PPARA/PRKCA/NOTCH1/IGF1/AGT	9
BP	GO:0001657	ureteric bud development	10/365	86/18862	6.24535461165283e-06	3.5569299278989e-05	1.36703197558772e-05	BCL2/GLI3/FGFR2/BMP4/MYC/AGT/GDNF/VEGFA/BMP2/SHH	10
BP	GO:0051952	regulation of amine transport	10/365	86/18862	6.24535461165283e-06	3.5569299278989e-05	1.36703197558772e-05	STXBP1/PINK1/SNCA/LEP/CXCL12/DRD4/GDNF/CNR1/KCNA2/P2RY12	10
BP	GO:2000181	negative regulation of blood vessel morphogenesis	13/365	148/18862	6.25914221799796e-06	3.56090764880449e-05	1.36856072981626e-05	KLF4/AGO1/CTNNB1/GTF2I/MECP2/GADD45A/PPARG/FASLG/STAT1/THBS4/GHRL/PRL/SERPINE1	13
BP	GO:0005996	monosaccharide metabolic process	18/365	272/18862	6.39591693420156e-06	3.63476973220532e-05	1.39694808403442e-05	EP300/PMM2/MTOR/ATF4/GSK3B/MAN2B1/RORA/PPARA/SRC/HMGB1/ATF3/SLC2A1/LEP/GHRL/LEPR/IGF1/ADIPOQ/POMC	18
BP	GO:0051155	positive regulation of striated muscle cell differentiation	8/365	52/18862	6.51839198691366e-06	3.69634492519026e-05	1.42061322768912e-05	EDN1/BCL2/MEF2C/MTOR/NRG1/BMP4/IGF1/SHH	8
BP	GO:0071827	plasma lipoprotein particle organization	8/365	52/18862	6.51839198691366e-06	3.69634492519026e-05	1.42061322768912e-05	MFSD2A/AGTR1/CETP/APOE/ABCA1/LPL/AGT/MPO	8
BP	GO:1990776	response to angiotensin	6/365	25/18862	6.53827926602185e-06	3.69960580306577e-05	1.42186647822108e-05	CYBB/ARID1B/AGTR1/SRC/CAMK2A/CAV1	6
BP	GO:2000679	positive regulation of transcription regulatory region DNA binding	6/365	25/18862	6.53827926602185e-06	3.69960580306577e-05	1.42186647822108e-05	KLF4/PARP1/CTNNB1/EP300/IFNG/IGF1	6
BP	GO:1901343	negative regulation of vasculature development	13/365	149/18862	6.73943840727631e-06	3.80773028186239e-05	1.46342187089255e-05	KLF4/AGO1/CTNNB1/GTF2I/MECP2/GADD45A/PPARG/FASLG/STAT1/THBS4/GHRL/PRL/SERPINE1	13
BP	GO:0042481	regulation of odontogenesis	5/365	15/18862	6.75846662562125e-06	3.80773028186239e-05	1.46342187089255e-05	EDN1/BMP4/NGFR/BMP2/SHH	5
BP	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	5/365	15/18862	6.75846662562125e-06	3.80773028186239e-05	1.46342187089255e-05	LRRK2/KDR/CCL2/TLR2/IFNG	5
BP	GO:2000846	regulation of corticosteroid hormone secretion	5/365	15/18862	6.75846662562125e-06	3.80773028186239e-05	1.46342187089255e-05	AGTR1/GHRL/AGT/POMC/CRHR1	5
BP	GO:0072163	mesonephric epithelium development	10/365	87/18862	6.93667029558632e-06	3.89973494383446e-05	1.49878194752281e-05	BCL2/GLI3/FGFR2/BMP4/MYC/AGT/GDNF/VEGFA/BMP2/SHH	10
BP	GO:0072164	mesonephric tubule development	10/365	87/18862	6.93667029558632e-06	3.89973494383446e-05	1.49878194752281e-05	BCL2/GLI3/FGFR2/BMP4/MYC/AGT/GDNF/VEGFA/BMP2/SHH	10
BP	GO:0071229	cellular response to acid chemical	9/365	69/18862	7.02326139028339e-06	3.94417919707546e-05	1.51586317109008e-05	XBP1/CYBB/DNMT3A/ATP7A/CEBPB/MTOR/MMP2/SOCS1/VEGFA	9
BP	GO:0007416	synapse assembly	14/365	173/18862	7.19371069331644e-06	4.03557146503947e-05	1.55098788683113e-05	CEL/MEF2C/MECP2/SNCA/NLGN3/TLR2/GHRL/APP/IL1RAPL1/CDH2/GABRG2/NTRK1/NRXN1/ERBB4	14
BP	GO:0010463	mesenchymal cell proliferation	7/365	38/18862	7.22077123696243e-06	4.04208734270175e-05	1.55349212877402e-05	FGFR2/STAT1/BMP4/MYC/VEGFA/BMP2/SHH	7
BP	GO:0097242	amyloid-beta clearance	7/365	38/18862	7.22077123696243e-06	4.04208734270175e-05	1.55349212877402e-05	LRP2/IGF1R/APOE/IFNG/CLU/MME/C3	7
BP	GO:0015908	fatty acid transport	13/365	150/18862	7.25197839621005e-06	4.0508916676375e-05	1.55687588778941e-05	ABCD1/EDN1/STXBP1/MFSD2A/GJA1/PPARA/PPARG/SLC2A1/APOE/ACSL4/DRD4/TNFSF11/PLA2G4A	13
BP	GO:1903364	positive regulation of cellular protein catabolic process	13/365	150/18862	7.25197839621005e-06	4.0508916676375e-05	1.55687588778941e-05	LRP2/NUPR1/STUB1/HSP90AA1/GSK3B/UBQLN2/LRRK2/APOE/HSPA1B/HSPA1A/CLU/AURKA/CAV1	13
BP	GO:0002576	platelet degranulation	12/365	128/18862	7.2899946754856e-06	4.06345390111732e-05	1.56170392072787e-05	STXBP1/MANF/LAMP2/SERPINA1/TF/SERPINA3/APP/IGF1/SERPINE1/CLU/VEGFA/FN1	12
BP	GO:0045667	regulation of osteoblast differentiation	12/365	128/18862	7.2899946754856e-06	4.06345390111732e-05	1.56170392072787e-05	MEF2C/CEBPB/GLI3/ATF4/HDAC4/PPARG/IL6/NOTCH1/FGFR2/BMP4/IGF1/BMP2	12
BP	GO:0003179	heart valve morphogenesis	8/365	53/18862	7.54902811491001e-06	4.1899907903965e-05	1.61033574008964e-05	NPPA/MEF2C/MTOR/GATA4/NOTCH1/ELN/BMP4/BMP2	8
BP	GO:0007215	glutamate receptor signaling pathway	8/365	53/18862	7.54902811491001e-06	4.1899907903965e-05	1.61033574008964e-05	PLP1/TRPM1/CLN3/GRIN1/APP/GRIN2B/GRIA1/GRIN2A	8
BP	GO:0010524	positive regulation of calcium ion transport into cytosol	8/365	53/18862	7.54902811491001e-06	4.1899907903965e-05	1.61033574008964e-05	CD4/HTT/P2RX7/SNCA/GRIN1/BAX/CAV1/CALCR	8
BP	GO:0021885	forebrain cell migration	8/365	53/18862	7.54902811491001e-06	4.1899907903965e-05	1.61033574008964e-05	GLI3/RTN4/CXCR4/LRRK2/CXCL12/P2RY12/FOXG1/RELN	8
BP	GO:0010721	negative regulation of cell development	14/365	174/18862	7.68815505334467e-06	4.26269105394131e-05	1.63827657303096e-05	SPP1/EDNRB/NF1/GSK3B/RTN4/SORL1/DICER1/B2M/IL6/NOTCH1/NGFR/IGF1/VEGFA/FBN1	14
BP	GO:0003205	cardiac chamber development	13/365	151/18862	7.79860705329267e-06	4.31935548327342e-05	1.66005436689973e-05	LRP2/MATR3/MEF2C/GATA4/ANK2/CHD7/NRG1/NOTCH1/FGFR2/BMP4/RYR2/SCN5A/BMP2	13
BP	GO:0071156	regulation of cell cycle arrest	11/365	108/18862	7.91121964337937e-06	4.36552949056798e-05	1.67780038543037e-05	MIF/EP300/HSP90AB1/GADD45A/ATM/BRCA1/CCND1/CDKN1A/BAX/AURKA/ADAM10	11
BP	GO:0010517	regulation of phospholipase activity	9/365	70/18862	7.92367790607485e-06	4.36552949056798e-05	1.67780038543037e-05	CCL5/HRAS/SNCA/AGTR1/EGFR/FGFR2/KIT/PDGFRB/P2RY12	9
BP	GO:0032371	regulation of sterol transport	9/365	70/18862	7.92367790607485e-06	4.36552949056798e-05	1.67780038543037e-05	NFKBIA/CETP/LEP/FURIN/APOE/ABCA1/ADIPOQ/CAV1/SHH	9
BP	GO:0032374	regulation of cholesterol transport	9/365	70/18862	7.92367790607485e-06	4.36552949056798e-05	1.67780038543037e-05	NFKBIA/CETP/LEP/FURIN/APOE/ABCA1/ADIPOQ/CAV1/SHH	9
BP	GO:0048844	artery morphogenesis	9/365	70/18862	7.92367790607485e-06	4.36552949056798e-05	1.67780038543037e-05	LRP2/AKT3/NF1/CHD7/APOE/NOTCH1/BMP4/PDGFRB/VEGFA	9
BP	GO:0019318	hexose metabolic process	17/365	250/18862	8.08348984711884e-06	4.44889441217876e-05	1.70983995770038e-05	EP300/PMM2/MTOR/ATF4/GSK3B/MAN2B1/RORA/PPARA/SRC/HMGB1/ATF3/LEP/GHRL/LEPR/IGF1/ADIPOQ/POMC	17
BP	GO:0045619	regulation of lymphocyte differentiation	14/365	175/18862	8.21248692738479e-06	4.51514249768193e-05	1.73530103032202e-05	XBP1/PTPRC/PRKDC/GLI3/IL18/HMGB1/CTLA4/BMP4/HLA-DRB1/NLRP3/IFNG/SOCS1/SHH/IL10	14
BP	GO:0010464	regulation of mesenchymal cell proliferation	6/365	26/18862	8.36187040396364e-06	4.59244802668895e-05	1.76501180117905e-05	FGFR2/STAT1/BMP4/MYC/VEGFA/SHH	6
BP	GO:0016571	histone methylation	12/365	130/18862	8.55409326063487e-06	4.69309477213447e-05	1.80369328269593e-05	CTNNB1/NSD1/MECP2/KMT2A/CREBBP/BRD4/KMT2D/KMT2C/DNMT1/BRCA1/MTHFR/TET1	12
BP	GO:0032963	collagen metabolic process	11/365	109/18862	8.64906464848292e-06	4.73366398105517e-05	1.81928521364287e-05	MMP9/PPARG/FURIN/CST3/IL6/BMP4/CTSD/MMP3/MMP2/PDGFRB/CTSB	11
BP	GO:0002066	columnar/cuboidal epithelial cell development	7/365	39/18862	8.65517086333549e-06	4.73366398105517e-05	1.81928521364287e-05	ARNTL/CLOCK/GSK3B/SRC/CDKN1A/BMP4/CDH2	7
BP	GO:0045933	positive regulation of muscle contraction	7/365	39/18862	8.65517086333549e-06	4.73366398105517e-05	1.81928521364287e-05	NPPA/EDN1/ATP1A1/KIT/KCNQ1/GHRL/CHRM3	7
BP	GO:0046622	positive regulation of organ growth	8/365	54/18862	8.71396162868901e-06	4.76084291905619e-05	1.82973087269802e-05	EDN1/MEF2C/MTOR/MAPK1/NOTCH1/FGFR2/IGF1/ERBB4	8
BP	GO:0048839	inner ear development	14/365	176/18862	8.76825591362132e-06	4.78551110030177e-05	1.83921157465895e-05	COL2A1/GLI3/CHD7/SOX2/NOTCH1/FGFR2/DLX5/BMP4/KCNQ1/PDGFRB/ADAM10/FOXG1/BMP2/SHH	14
BP	GO:0010498	proteasomal protein catabolic process	25/365	483/18862	8.82991696938773e-06	4.8141443143516e-05	1.85021615444078e-05	RPS27A/ARNTL/NUPR1/NEDD4L/UGGT1/PINK1/CTNNB1/STUB1/CLOCK/HSP90AB1/GSK3B/HUWE1/UBE2J1/UBQLN2/DDIT3/LRRK2/APOE/DNAJC10/HSPA1B/HSPA1A/CLU/AURKA/CAV1/UCHL1/SHH	25
BP	GO:0014743	regulation of muscle hypertrophy	9/365	71/18862	8.9210185056772e-06	4.84866156372944e-05	1.86348214071696e-05	EDN1/PARP1/MTOR/TNFRSF1A/PPARA/PRKCA/NOTCH1/IGF1/AGT	9
BP	GO:0051881	regulation of mitochondrial membrane potential	9/365	71/18862	8.9210185056772e-06	4.84866156372944e-05	1.86348214071696e-05	ABCD1/BCL2/PARP1/PINK1/SRC/UCP2/LRRK2/KDR/BAX	9
BP	GO:0070227	lymphocyte apoptotic process	9/365	71/18862	8.9210185056772e-06	4.84866156372944e-05	1.86348214071696e-05	CCL5/RPS6/GLI3/BCL2L11/FAS/FASLG/BMP4/BAX/IL10	9
BP	GO:0044409	entry into host	13/365	153/18862	9.0019439600182e-06	4.88756998825054e-05	1.87843578375134e-05	CCR5/CD4/DAG1/CTNNB1/SCARB2/ICAM1/SRC/EGFR/CXCR4/HSPA1B/HSPA1A/HLA-DRB1/CAV1	13
BP	GO:0009410	response to xenobiotic stimulus	12/365	131/18862	9.25529222203595e-06	5.01991704560996e-05	1.92930062026842e-05	CYP3A5/PTGS1/HSP90AB1/RORA/CYP2D6/CYP2U1/CYP2E1/AHR/GRIN1/GSTM1/CYP1A1/NQO1	12
BP	GO:0043470	regulation of carbohydrate catabolic process	10/365	90/18862	9.4222954249694e-06	5.10520644454346e-05	1.96207982533688e-05	NUPR1/EP300/SCARB2/P2RX7/HDAC4/PPARA/HMGB1/APP/IFNG/IGF1	10
BP	GO:0035930	corticosteroid hormone secretion	5/365	16/18862	9.67476428225229e-06	5.22577051117734e-05	2.00841611464713e-05	AGTR1/GHRL/AGT/POMC/CRHR1	5
BP	GO:1905288	vascular associated smooth muscle cell apoptotic process	5/365	16/18862	9.67476428225229e-06	5.22577051117734e-05	2.00841611464713e-05	ATF4/PPARG/DNMT1/IGF1/SOD2	5
BP	GO:1905459	regulation of vascular associated smooth muscle cell apoptotic process	5/365	16/18862	9.67476428225229e-06	5.22577051117734e-05	2.00841611464713e-05	ATF4/PPARG/DNMT1/IGF1/SOD2	5
BP	GO:0010595	positive regulation of endothelial cell migration	12/365	132/18862	1.00063417838828e-05	5.3992982367879e-05	2.07510788377646e-05	EDN1/AKT3/SP1/HSPB1/ETS1/PIK3CG/HMGB1/PRKCA/KDR/BMP4/AGT/VEGFA	12
BP	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	9/365	72/18862	1.00237113269709e-05	5.39930753132428e-05	2.07511145593804e-05	MMP9/KLF4/RPS6KA3/XIAP/SNCA/NGF/SRC/NGFR/VEGFA	9
BP	GO:1902991	regulation of amyloid precursor protein catabolic process	8/365	55/18862	1.00269906772014e-05	5.39930753132428e-05	2.07511145593804e-05	SP1/RTN4/SORL1/AGER/APOE/IFNG/IGF1/CLU	8
BP	GO:0002286	T cell activation involved in immune response	11/365	111/18862	1.03062966990575e-05	5.53831179906233e-05	2.1285348526855e-05	RPS6/ATP7A/MTOR/RORA/ICAM1/IL18/HMGB1/IL6/HLA-DRB1/NLRP3/IFNG	11
BP	GO:0007041	lysosomal transport	11/365	111/18862	1.03062966990575e-05	5.53831179906233e-05	2.1285348526855e-05	SORT1/PINK1/ATP13A2/CLN3/SCARB2/SORL1/LAMP2/ADRB2/LRRK2/HSPA1A/CLU	11
BP	GO:0060443	mammary gland morphogenesis	7/365	40/18862	1.03181289383825e-05	5.53898326805068e-05	2.12879291781366e-05	GLI3/SRC/AR/FGFR2/BMP4/BAX/CAV1	7
BP	GO:0007389	pattern specification process	23/365	426/18862	1.03365814126764e-05	5.54320359774061e-05	2.13041491367824e-05	LRP2/EDN1/MEF2C/EP300/PRKDC/GLI3/MED12/GATA4/ATM/DDIT3/NOTCH1/AR/FGFR2/BMP4/SATB2/GDNF/AURKA/C3/FOXG1/RELN/BMP2/SHH/ERBB4	23
BP	GO:0001823	mesonephros development	10/365	91/18862	1.04059671689847e-05	5.57470134723295e-05	2.14252041802831e-05	BCL2/GLI3/FGFR2/BMP4/MYC/AGT/GDNF/VEGFA/BMP2/SHH	10
BP	GO:0007263	nitric oxide mediated signal transduction	6/365	27/18862	1.05766183280238e-05	5.65454753103948e-05	2.17320763667044e-05	EGFR/APOE/AGT/VEGFA/NOS2/NOS1	6
BP	GO:0031069	hair follicle morphogenesis	6/365	27/18862	1.05766183280238e-05	5.65454753103948e-05	2.17320763667044e-05	BCL2/ATP7A/NOTCH1/FGFR2/NGFR/SHH	6
BP	GO:0016236	macroautophagy	19/365	311/18862	1.11497106785455e-05	5.95485568280683e-05	2.28862482349091e-05	GABARAP/MAP1LC3A/IKBKG/NUPR1/PINK1/HTT/ATP13A2/CLN3/MTOR/WDR45/HUWE1/MAPK3/SRC/LAMP2/UBQLN2/ADRB2/LRRK2/KDR/UCHL1	19
BP	GO:0002292	T cell differentiation involved in immune response	9/365	73/18862	1.12407373728035e-05	5.99735162173838e-05	2.30495725301009e-05	ATP7A/MTOR/RORA/IL18/HMGB1/IL6/HLA-DRB1/NLRP3/IFNG	9
BP	GO:0071347	cellular response to interleukin-1	14/365	180/18862	1.13390570055016e-05	6.04364810252501e-05	2.32275034167796e-05	CCL5/EDN1/RPS27A/NFKBIA/IKBKG/CEBPB/RORA/ICAM1/MAPK3/IL1R1/IL1RN/IL6/CCL2/EGR1	14
BP	GO:0045185	maintenance of protein location	10/365	92/18862	1.14769577046179e-05	6.09376609912107e-05	2.34201215039728e-05	CD4/NFKBIA/PINK1/TXN/SORL1/GJA1/ANK3/FBN1/CAV1/IL10	10
BP	GO:1901655	cellular response to ketone	10/365	92/18862	1.14769577046179e-05	6.09376609912107e-05	2.34201215039728e-05	SPP1/KLF4/EIF4E/ICAM1/PPARG/SRC/CFTR/EGFR/AHR/AR	10
BP	GO:0010883	regulation of lipid storage	8/365	56/18862	1.15029440312029e-05	6.09376609912107e-05	2.34201215039728e-05	NFKBIA/PPARA/PPARG/LEP/IL6/ABCA1/LPL/C3	8
BP	GO:0021872	forebrain generation of neurons	8/365	56/18862	1.15029440312029e-05	6.09376609912107e-05	2.34201215039728e-05	ATP7A/GLI3/B2M/FGFR2/DLX5/SATB2/FOXG1/ERBB4	8
BP	GO:0060135	maternal process involved in female pregnancy	8/365	56/18862	1.15029440312029e-05	6.09376609912107e-05	2.34201215039728e-05	SPP1/MTOR/GJA1/MAPK1/MAPK3/AR/GHRL/CNR1	8
BP	GO:0071825	protein-lipid complex subunit organization	8/365	56/18862	1.15029440312029e-05	6.09376609912107e-05	2.34201215039728e-05	MFSD2A/AGTR1/CETP/APOE/ABCA1/LPL/AGT/MPO	8
BP	GO:0035107	appendage morphogenesis	12/365	134/18862	1.16700759313943e-05	6.16359005296847e-05	2.36884753358058e-05	COL2A1/CTNNB1/GLI3/CREBBP/CHD7/BCL2L11/NOTCH1/FGFR2/DLX5/BMP4/BAX/SHH	12
BP	GO:0035108	limb morphogenesis	12/365	134/18862	1.16700759313943e-05	6.16359005296847e-05	2.36884753358058e-05	COL2A1/CTNNB1/GLI3/CREBBP/CHD7/BCL2L11/NOTCH1/FGFR2/DLX5/BMP4/BAX/SHH	12
BP	GO:0071482	cellular response to light stimulus	12/365	134/18862	1.16700759313943e-05	6.16359005296847e-05	2.36884753358058e-05	MMP9/TRPM1/PARP1/EP300/ATF4/CREBBP/CDKN1A/MMP3/BAX/MMP2/MYC/MME	12
BP	GO:0033574	response to testosterone	7/365	41/18862	1.2237338492763e-05	6.43074595091584e-05	2.47152334175335e-05	SPP1/GNRH1/EDN1/AR/BGLAP/FOXP2/NQO1	7
BP	GO:0042088	T-helper 1 type immune response	7/365	41/18862	1.2237338492763e-05	6.43074595091584e-05	2.47152334175335e-05	HRAS/MTOR/IL18/IL1R1/HMGB1/HLA-DRB1/PLA2G4A	7
BP	GO:0044091	membrane biogenesis	7/365	41/18862	1.2237338492763e-05	6.43074595091584e-05	2.47152334175335e-05	CEL/NLGN3/ANK3/IL1RAPL1/CDH2/CAV1/NRXN1	7
BP	GO:1903580	positive regulation of ATP metabolic process	7/365	41/18862	1.2237338492763e-05	6.43074595091584e-05	2.47152334175335e-05	NUPR1/PINK1/P2RX7/PPARA/APP/IFNG/IGF1	7
BP	GO:1905314	semi-lunar valve development	7/365	41/18862	1.2237338492763e-05	6.43074595091584e-05	2.47152334175335e-05	NPPA/TNFRSF1A/GATA4/NOTCH1/ELN/BMP4/BMP2	7
BP	GO:0007422	peripheral nervous system development	9/365	74/18862	1.25816538669115e-05	6.60505279231844e-05	2.53851454781903e-05	EDNRB/DAG1/NF1/MED12/NGF/DICER1/ALDH3A2/SERPINI1/GDNF	9
BP	GO:0007631	feeding behavior	10/365	93/18862	1.26416275158772e-05	6.62988761704424e-05	2.54805929573267e-05	MTOR/FOS/LEP/GHRL/APP/LEPR/CNR1/HTR2C/GDF15/NPY	10
BP	GO:0061136	regulation of proteasomal protein catabolic process	14/365	182/18862	1.28584412770068e-05	6.73684500939473e-05	2.58916614302301e-05	NUPR1/PINK1/STUB1/HSP90AB1/GSK3B/UBQLN2/LRRK2/APOE/HSPA1B/HSPA1A/CLU/AURKA/CAV1/SHH	14
BP	GO:0086065	cell communication involved in cardiac conduction	8/365	57/18862	1.31577267557422e-05	6.88675418395545e-05	2.64678061370771e-05	ATP1A1/GJA1/ANK2/KCNQ1/RYR2/CASQ2/CAV1/SCN5A	8
BP	GO:0006457	protein folding	16/365	233/18862	1.3192044276208e-05	6.89781815601127e-05	2.65103282105616e-05	NPPA/UGGT1/ATF6/DNAJC3/DNAJC5/HSP90AA1/HSP90AB1/HSPB1/B2M/CANX/FKBP5/PPIB/DNAJC10/HSPA1B/HSPA1A/CLU	16
BP	GO:0000303	response to superoxide	6/365	28/18862	1.32429103651241e-05	6.90372438755571e-05	2.65330275820424e-05	ATP7A/UCP2/PRDX1/SOD2/NQO1/MPO	6
BP	GO:0010575	positive regulation of vascular endothelial growth factor production	6/365	28/18862	1.32429103651241e-05	6.90372438755571e-05	2.65330275820424e-05	ATF4/RORA/GATA4/BRCA1/IL6/C3	6
BP	GO:0033028	myeloid cell apoptotic process	6/365	28/18862	1.32429103651241e-05	6.90372438755571e-05	2.65330275820424e-05	BCL2/MEF2C/IL6/KITLG/ADIPOQ/CDKN2A	6
BP	GO:0003231	cardiac ventricle development	11/365	114/18862	1.33085565295259e-05	6.92415356615689e-05	2.66115428773924e-05	LRP2/MATR3/MEF2C/GATA4/CHD7/NRG1/NOTCH1/FGFR2/BMP4/RYR2/SCN5A	11
BP	GO:0055007	cardiac muscle cell differentiation	11/365	114/18862	1.33085565295259e-05	6.92415356615689e-05	2.66115428773924e-05	EDN1/MEF2C/MTOR/GATA4/PPARA/NRG1/BMP4/IGF1/PDGFRB/VEGFA/BMP2	11
BP	GO:0015732	prostaglandin transport	5/365	17/18862	1.34888842355921e-05	6.98326608200684e-05	2.68387295270098e-05	EDN1/LEP/TNFSF11/PLA2G4A/NOS2	5
BP	GO:0034374	low-density lipoprotein particle remodeling	5/365	17/18862	1.34888842355921e-05	6.98326608200684e-05	2.68387295270098e-05	AGTR1/CETP/APOE/AGT/MPO	5
BP	GO:0034393	positive regulation of smooth muscle cell apoptotic process	5/365	17/18862	1.34888842355921e-05	6.98326608200684e-05	2.68387295270098e-05	ATF4/PPARG/IFNG/SOD2/CDKN2A	5
BP	GO:0060749	mammary gland alveolus development	5/365	17/18862	1.34888842355921e-05	6.98326608200684e-05	2.68387295270098e-05	CCND1/AR/TNFSF11/VEGFA/ERBB4	5
BP	GO:0061377	mammary gland lobule development	5/365	17/18862	1.34888842355921e-05	6.98326608200684e-05	2.68387295270098e-05	CCND1/AR/TNFSF11/VEGFA/ERBB4	5
BP	GO:0002683	negative regulation of immune system process	22/365	403/18862	1.35775043862015e-05	7.02219940290303e-05	2.69883616413887e-05	GNRH1/PTPRC/MIF/CEBPB/PRKDC/GLI3/ATM/PPARG/HMGB1/CTLA4/KITLG/CXCL12/BMP4/CCL2/HLA-DRB1/MYC/SOCS1/ADIPOQ/CNR1/FBN1/SHH/IL10	22
BP	GO:0015837	amine transport	10/365	94/18862	1.39066943948503e-05	7.17826809296314e-05	2.7588179163873e-05	STXBP1/PINK1/SNCA/LEP/CXCL12/DRD4/GDNF/CNR1/KCNA2/P2RY12	10
BP	GO:0061097	regulation of protein tyrosine kinase activity	10/365	94/18862	1.39066943948503e-05	7.17826809296314e-05	2.7588179163873e-05	CCL5/PTPRC/SRC/NRG1/GHRL/APP/AGT/NOX4/CAV1/RELN	10
BP	GO:0006305	DNA alkylation	9/365	75/18862	1.40566178902368e-05	7.24137185408457e-05	2.78307053338608e-05	DNMT3A/PARP1/MECP2/KMT2A/DNMT1/BRCA1/FOS/MYC/CYP1A1	9
BP	GO:0006306	DNA methylation	9/365	75/18862	1.40566178902368e-05	7.24137185408457e-05	2.78307053338608e-05	DNMT3A/PARP1/MECP2/KMT2A/DNMT1/BRCA1/FOS/MYC/CYP1A1	9
BP	GO:0006509	membrane protein ectodomain proteolysis	7/365	42/18862	1.44427913776161e-05	7.42265477132854e-05	2.85274284898515e-05	DAG1/PSEN2/FURIN/APOE/IFNG/ADAM10/IL10	7
BP	GO:0014002	astrocyte development	7/365	42/18862	1.44427913776161e-05	7.42265477132854e-05	2.85274284898515e-05	PLP1/NF1/EGFR/AGER/IL6/APP/IFNG	7
BP	GO:0007009	plasma membrane organization	11/365	115/18862	1.44652423896735e-05	7.42265477132854e-05	2.85274284898515e-05	ABCD1/PTPRC/CLN3/P2RX7/ANK2/CXCR4/AR/FASLG/ANK3/CLU/CAV1	11
BP	GO:0030218	erythrocyte differentiation	11/365	115/18862	1.44652423896735e-05	7.42265477132854e-05	2.85274284898515e-05	RPS6/PRKDC/ETS1/P4HTM/B2M/STAT1/HSPA1B/BMP4/KIT/HSPA1A/VEGFA	11
BP	GO:0002703	regulation of leukocyte mediated immunity	15/365	209/18862	1.45618538500119e-05	7.45760695214893e-05	2.8661759921076e-05	PTPRC/STXBP1/ICAM1/IL18/IL1R1/HMGB1/AGER/LEP/B2M/IL6/HLA-DRB1/NLRP3/NOS2/C3/IL10	15
BP	GO:0006836	neurotransmitter transport	15/365	209/18862	1.45618538500119e-05	7.45760695214893e-05	2.8661759921076e-05	STXBP1/MEF2C/DNAJC5/GSK3B/SNCA/SLC6A8/LRRK2/DRD4/GDNF/CNR1/CAMK2A/SLC6A1/NOS1/NRXN1/SLC6A4	15
BP	GO:0016241	regulation of macroautophagy	13/365	160/18862	1.46017941219556e-05	7.47075175311001e-05	2.87122792273057e-05	IKBKG/NUPR1/PINK1/HTT/ATP13A2/CLN3/MTOR/MAPK3/UBQLN2/ADRB2/LRRK2/KDR/UCHL1	13
BP	GO:0003158	endothelium development	12/365	137/18862	1.46189451943989e-05	7.47222257299649e-05	2.87179320173688e-05	CTNNB1/TNFRSF1A/GJA1/ICAM1/CXCR4/NRG1/KDR/NOTCH1/BMP4/VEGFA/XDH/PROC	12
BP	GO:0002763	positive regulation of myeloid leukocyte differentiation	8/365	58/18862	1.50083660612791e-05	7.66378419168146e-05	2.94541592227003e-05	CD4/FOS/PRKCA/KITLG/JUN/HLA-DRB1/IFNG/TNFSF11	8
BP	GO:0055092	sterol homeostasis	10/365	95/18862	1.52792469157856e-05	7.79450081454403e-05	2.99565413522789e-05	XBP1/ABCD1/RORA/IL18/CETP/GRAMD1B/APOE/ABCA1/LPL/CAV1	10
BP	GO:0006006	glucose metabolic process	15/365	210/18862	1.5410883233671e-05	7.85399832960407e-05	3.01852076662176e-05	EP300/MTOR/ATF4/GSK3B/RORA/PPARA/SRC/HMGB1/ATF3/LEP/GHRL/LEPR/IGF1/ADIPOQ/POMC	15
BP	GO:0007626	locomotory behavior	13/365	161/18862	1.56112949809367e-05	7.94839668581935e-05	3.05480080980648e-05	ATP7A/MTOR/MECP2/CHD7/LRRK2/APOE/CXCL12/APP/DRD4/GDNF/HTR2C/EGR1/DBH	13
BP	GO:0032874	positive regulation of stress-activated MAPK cascade	11/365	116/18862	1.57081669200517e-05	7.98994612823619e-05	3.07076947309281e-05	EIF2AK2/HRAS/GADD45A/HMGB1/AGER/LEP/APP/TNFSF11/VEGFA/XDH/BMP2	11
BP	GO:0098754	detoxification	12/365	138/18862	1.57369765956593e-05	7.99682868948359e-05	3.07341464223863e-05	HBA1/PTGS1/ATP7A/TXN/APOE/PRDX1/HBB/GSTM1/SOD2/HP/NQO1/MPO	12
BP	GO:1903320	regulation of protein modification by small protein conjugation or removal	16/365	237/18862	1.62997561943242e-05	8.27477438613897e-05	3.18023728494089e-05	PINK1/CTNNB1/STUB1/RPL5/MTOR/HSP90AA1/XIAP/HSP90AB1/HUWE1/HDAC4/BRCA1/LRRK2/HSPA1B/HSPA1A/EGR1/CAV1	16
BP	GO:0000305	response to oxygen radical	6/365	29/18862	1.64269597272673e-05	8.31515543641364e-05	3.195756901029e-05	ATP7A/UCP2/PRDX1/SOD2/NQO1/MPO	6
BP	GO:0036296	response to increased oxygen levels	6/365	29/18862	1.64269597272673e-05	8.31515543641364e-05	3.195756901029e-05	PPARG/FAS/CDKN1A/PDGFRB/CYP1A1/CAV1	6
BP	GO:1900745	positive regulation of p38MAPK cascade	6/365	29/18862	1.64269597272673e-05	8.31515543641364e-05	3.195756901029e-05	GADD45A/AGER/LEP/VEGFA/XDH/BMP2	6
BP	GO:0032635	interleukin-6 production	13/365	162/18862	1.66815662592171e-05	8.42773337845002e-05	3.23902388959194e-05	XBP1/CEBPB/HMGB1/AGER/LEP/IL6/TLR2/GHRL/APP/IFNG/LPL/NOS2/IL10	13
BP	GO:0055088	lipid homeostasis	13/365	162/18862	1.66815662592171e-05	8.42773337845002e-05	3.23902388959194e-05	XBP1/ABCD1/ATP13A2/RTN4/RORA/IL18/PPARG/CETP/GRAMD1B/APOE/ABCA1/LPL/CAV1	13
BP	GO:0043030	regulation of macrophage activation	8/365	59/18862	1.70730572509049e-05	8.61720170214429e-05	3.31184209577011e-05	PTPRC/MIF/RORA/ATM/LRRK2/IL6/PLA2G4A/IL10	8
BP	GO:0045930	negative regulation of mitotic cell cycle	19/365	321/18862	1.7374807175923e-05	8.76105402300395e-05	3.36712874081623e-05	KLF4/BCL2/CTNNB1/EP300/PRKDC/RAD21/GADD45A/ATM/BRCA1/EGFR/CCND1/CDKN1A/BMP4/CCL2/BAX/AURKA/GJC2/CDKN2A/IL10	19
BP	GO:0032481	positive regulation of type I interferon production	9/365	77/18862	1.74524597005417e-05	8.78328596852261e-05	3.37567312628898e-05	CTNNB1/EP300/PRKDC/HSP90AA1/CREBBP/CD14/HMGB1/STAT1/TLR2	9
BP	GO:0043407	negative regulation of MAP kinase activity	9/365	77/18862	1.74524597005417e-05	8.78328596852261e-05	3.37567312628898e-05	NPPA/NF1/SORL1/APOE/BMP4/AGT/ADIPOQ/CAV1/UCHL1	9
BP	GO:0006704	glucocorticoid biosynthetic process	5/365	18/18862	1.83812985660094e-05	9.23298624707227e-05	3.54850606724355e-05	HSD11B1/ATP1A1/HSD11B2/CYP17A1/BMP2	5
BP	GO:2000831	regulation of steroid hormone secretion	5/365	18/18862	1.83812985660094e-05	9.23298624707227e-05	3.54850606724355e-05	AGTR1/GHRL/AGT/POMC/CRHR1	5
BP	GO:0070304	positive regulation of stress-activated protein kinase signaling cascade	11/365	118/18862	1.84743205372681e-05	9.27081435206722e-05	3.56304451195633e-05	EIF2AK2/HRAS/GADD45A/HMGB1/AGER/LEP/APP/TNFSF11/VEGFA/XDH/BMP2	11
BP	GO:0010518	positive regulation of phospholipase activity	8/365	60/18862	1.93712096809043e-05	9.70228817893329e-05	3.72887249561401e-05	CCL5/HRAS/AGTR1/EGFR/FGFR2/KIT/PDGFRB/P2RY12	8
BP	GO:0050994	regulation of lipid catabolic process	8/365	60/18862	1.93712096809043e-05	9.70228817893329e-05	3.72887249561401e-05	ABCD1/BSCL2/MTOR/MFSD2A/SORL1/PPARA/PIK3CG/CNR1	8
BP	GO:0002709	regulation of T cell mediated immunity	9/365	78/18862	1.93968670485773e-05	9.70585106426896e-05	3.7302418164266e-05	PTPRC/IL18/IL1R1/HMGB1/AGER/B2M/IL6/HLA-DRB1/NLRP3	9
BP	GO:0007254	JNK cascade	14/365	189/18862	1.96893154015513e-05	9.84277715489202e-05	3.78286650905992e-05	NPPA/RPS27A/IGF1R/IKBKG/HRAS/PINK1/GADD45A/EGFR/HMGB1/AGER/TF/APP/TNFSF11/CD40LG	14
BP	GO:0010677	negative regulation of cellular carbohydrate metabolic process	7/365	44/18862	1.98444660915482e-05	9.88258187660925e-05	3.79816462526402e-05	NUPR1/EP300/GSK3B/HDAC4/PPARA/LEPR/ADIPOQ	7
BP	GO:0010874	regulation of cholesterol efflux	7/365	44/18862	1.98444660915482e-05	9.88258187660925e-05	3.79816462526402e-05	NFKBIA/CETP/APOE/ABCA1/ADIPOQ/CAV1/SHH	7
BP	GO:0048546	digestive tract morphogenesis	7/365	44/18862	1.98444660915482e-05	9.88258187660925e-05	3.79816462526402e-05	BCL2/GLI3/GATA4/NOTCH1/FGFR2/BMP4/SHH	7
BP	GO:0051150	regulation of smooth muscle cell differentiation	7/365	44/18862	1.98444660915482e-05	9.88258187660925e-05	3.79816462526402e-05	MECP2/DNMT1/FGFR2/BMP4/KIT/SOD2/SHH	7
BP	GO:0034766	negative regulation of ion transmembrane transport	11/365	119/18862	2.00089973025906e-05	9.95504675682121e-05	3.82601499352117e-05	MMP9/NEDD4L/ATP7A/MTOR/LEP/ANK3/DRD4/CASQ2/CRHR1/CAV1/KCNH2	11
BP	GO:0110110	positive regulation of animal organ morphogenesis	6/365	30/18862	2.02010126077848e-05	0.00010041035136671	3.85906283735461e-05	EDN1/AR/BMP4/NGFR/GDNF/BMP2	6
BP	GO:1903050	regulation of proteolysis involved in cellular protein catabolic process	15/365	215/18862	2.03490667734254e-05	0.000101050299328376	3.88365790512492e-05	NUPR1/PINK1/STUB1/RPL5/HSP90AB1/GSK3B/UBQLN2/LRRK2/APOE/HSPA1B/HSPA1A/CLU/AURKA/CAV1/SHH	15
BP	GO:0001776	leukocyte homeostasis	9/365	79/18862	2.152242984636e-05	0.000106710933938341	4.1012126129994e-05	BCL2/MEF2C/RPS6/BCL2L11/HMGB1/FAS/IL6/KITLG/BAX	9
BP	GO:0042113	B cell activation	19/365	326/18862	2.15297566371585e-05	0.000106710933938341	4.1012126129994e-05	XBP1/PTPRC/MIF/BCL2/MEF2C/EP300/PRKDC/HDAC4/ATM/CTLA4/VCAM1/AHR/CDKN1A/IL6/KIT/BAX/NTRK1/CD40LG/IL10	19
BP	GO:0048469	cell maturation	13/365	166/18862	2.1634144669849e-05	0.00010701689134959	4.11297144920994e-05	EDNRB/BCL2/MTOR/MECP2/PPARG/CFTR/LRRK2/CDKN1A/BRCA2/APP/AURKA/VEGFA/C3	13
BP	GO:0001676	long-chain fatty acid metabolic process	11/365	120/18862	2.16528253609506e-05	0.00010701689134959	4.11297144920994e-05	PLP1/ABCD1/PTGS1/CYP2D6/CYP2U1/CYP2E1/MAPK3/GSTM1/ACSL4/PLA2G4A/CYP1A1	11
BP	GO:0034763	negative regulation of transmembrane transport	11/365	120/18862	2.16528253609506e-05	0.00010701689134959	4.11297144920994e-05	MMP9/NEDD4L/ATP7A/MTOR/LEP/ANK3/DRD4/CASQ2/CRHR1/CAV1/KCNH2	11
BP	GO:0033619	membrane protein proteolysis	8/365	61/18862	2.19234926518851e-05	0.00010815038693682	4.15653499258419e-05	DAG1/PSEN2/FURIN/APOE/NGFR/IFNG/ADAM10/IL10	8
BP	GO:0071230	cellular response to amino acid stimulus	8/365	61/18862	2.19234926518851e-05	0.00010815038693682	4.15653499258419e-05	XBP1/CYBB/DNMT3A/ATP7A/CEBPB/MTOR/MMP2/SOCS1	8
BP	GO:1901987	regulation of cell cycle phase transition	24/365	478/18862	2.19708984368074e-05	0.000108220978078752	4.15924801617953e-05	KLF4/BCL2/EP300/PRKDC/MECP2/HSP90AA1/BRD4/DYNC1H1/RAD21/GADD45A/ATM/BRCA1/ALMS1/EGFR/CCND1/CDKN1A/CCL2/BAX/APP/TERT/AURKA/CYP1A1/GJC2/CDKN2A	24
BP	GO:0002824	positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	10/365	99/18862	2.19998319976675e-05	0.000108220978078752	4.15924801617953e-05	PTPRC/CD4/IL18/IL1R1/B2M/IL6/HLA-DRB1/NLRP3/PLA2G4A/C3	10
BP	GO:0051588	regulation of neurotransmitter transport	10/365	99/18862	2.19998319976675e-05	0.000108220978078752	4.15924801617953e-05	STXBP1/MEF2C/GSK3B/SNCA/LRRK2/DRD4/GDNF/CNR1/CAMK2A/NOS1	10
BP	GO:1903792	negative regulation of anion transport	15/365	217/18862	2.26865556026472e-05	0.000111494302370193	4.28505142146369e-05	TXN/MTOR/UBE2J1/SNCA/UCP2/LEP/LRRK2/APOE/GHRL/DRD4/ADIPOQ/CNR1/P2RY12/NOS1/SHH	15
BP	GO:0001974	blood vessel remodeling	7/365	45/18862	2.3113025819583e-05	0.000113059417887568	4.34520337837906e-05	MEF2C/ATP7A/CHD7/CST3/BAX/AGT/DBH	7
BP	GO:0017144	drug metabolic process	7/365	45/18862	2.3113025819583e-05	0.000113059417887568	4.34520337837906e-05	CYP3A5/CYP2D6/CYP2U1/BCHE/CYP2E1/CYP1A1/NOS1	7
BP	GO:0042551	neuron maturation	7/365	45/18862	2.3113025819583e-05	0.000113059417887568	4.34520337837906e-05	EDNRB/BCL2/MTOR/MECP2/LRRK2/APP/C3	7
BP	GO:0048538	thymus development	7/365	45/18862	2.3113025819583e-05	0.000113059417887568	4.34520337837906e-05	BCL2/PRKDC/MAPK1/ATM/MAPK3/BCL2L11/SHH	7
BP	GO:0060986	endocrine hormone secretion	7/365	45/18862	2.3113025819583e-05	0.000113059417887568	4.34520337837906e-05	GJA1/AGTR1/LEP/GHRL/AGT/POMC/CRHR1	7
BP	GO:0006304	DNA modification	11/365	121/18862	2.34122210014927e-05	0.000114202763021261	4.38914546856845e-05	DNMT3A/PARP1/USP9X/MECP2/KMT2A/DNMT1/BRCA1/FOS/TET1/MYC/CYP1A1	11
BP	GO:0034101	erythrocyte homeostasis	11/365	121/18862	2.34122210014927e-05	0.000114202763021261	4.38914546856845e-05	RPS6/PRKDC/ETS1/P4HTM/B2M/STAT1/HSPA1B/BMP4/KIT/HSPA1A/VEGFA	11
BP	GO:0042177	negative regulation of protein catabolic process	11/365	121/18862	2.34122210014927e-05	0.000114202763021261	4.38914546856845e-05	RPL5/ATP13A2/HSP90AB1/SNCA/EGFR/FURIN/CST3/NOS2/GRIN2A/SHH/IL10	11
BP	GO:0010833	telomere maintenance via telomere lengthening	9/365	80/18862	2.38426669114203e-05	0.000116086063827324	4.46152621470983e-05	PARP1/HSP90AA1/HSP90AB1/HNRNPA1/MAPK1/ATM/MAPK3/SRC/TERT	9
BP	GO:2000117	negative regulation of cysteine-type endopeptidase activity	9/365	80/18862	2.38426669114203e-05	0.000116086063827324	4.46152621470983e-05	MMP9/KLF4/RPS6KA3/XIAP/SNCA/NGF/SRC/NGFR/VEGFA	9
BP	GO:0043266	regulation of potassium ion transport	10/365	100/18862	2.40300843441788e-05	0.000116889834068245	4.49241745076558e-05	NPPA/NEDD4L/ATF4/ANK2/ANK3/KCNQ1/CASQ2/CAV1/KCNH2/NOS1	10
BP	GO:0032095	regulation of response to food	5/365	19/18862	2.45513752736457e-05	0.00011866080366205	4.56048098059606e-05	MTOR/PPARA/LEP/GHRL/NPY	5
BP	GO:0045780	positive regulation of bone resorption	5/365	19/18862	2.45513752736457e-05	0.00011866080366205	4.56048098059606e-05	SPP1/EGFR/TF/PRKCA/TNFSF11	5
BP	GO:0072074	kidney mesenchyme development	5/365	19/18862	2.45513752736457e-05	0.00011866080366205	4.56048098059606e-05	STAT1/BMP4/PDGFRB/MYC/SHH	5
BP	GO:0086014	atrial cardiac muscle cell action potential	5/365	19/18862	2.45513752736457e-05	0.00011866080366205	4.56048098059606e-05	GJA1/ANK2/KCNQ1/RYR2/SCN5A	5
BP	GO:0086026	atrial cardiac muscle cell to AV node cell signaling	5/365	19/18862	2.45513752736457e-05	0.00011866080366205	4.56048098059606e-05	GJA1/ANK2/KCNQ1/RYR2/SCN5A	5
BP	GO:0086066	atrial cardiac muscle cell to AV node cell communication	5/365	19/18862	2.45513752736457e-05	0.00011866080366205	4.56048098059606e-05	GJA1/ANK2/KCNQ1/RYR2/SCN5A	5
BP	GO:0055001	muscle cell development	13/365	168/18862	2.45616789143689e-05	0.00011866080366205	4.56048098059606e-05	EDN1/BCL2/MTOR/HDAC4/GATA4/PPARA/ANK2/NOTCH1/BMP4/KRT8/IGF1/PDGFRB/VEGFA	13
BP	GO:0032373	positive regulation of sterol transport	6/365	31/18862	2.46435409974491e-05	0.00011866080366205	4.56048098059606e-05	NFKBIA/CETP/APOE/ABCA1/ADIPOQ/CAV1	6
BP	GO:0032376	positive regulation of cholesterol transport	6/365	31/18862	2.46435409974491e-05	0.00011866080366205	4.56048098059606e-05	NFKBIA/CETP/APOE/ABCA1/ADIPOQ/CAV1	6
BP	GO:0042744	hydrogen peroxide catabolic process	6/365	31/18862	2.46435409974491e-05	0.00011866080366205	4.56048098059606e-05	HBA1/SNCA/PRDX1/HBB/HP/MPO	6
BP	GO:1904837	beta-catenin-TCF complex assembly	6/365	31/18862	2.46435409974491e-05	0.00011866080366205	4.56048098059606e-05	CTNNB1/EP300/CREBBP/KMT2D/TERT/MYC	6
BP	GO:0002437	inflammatory response to antigenic stimulus	8/365	62/18862	2.475188114789e-05	0.000118963586710796	4.57211781679164e-05	ICAM1/HMGB1/IL1RN/NOTCH1/HLA-DRB1/CNR1/C3/IL10	8
BP	GO:0031571	mitotic G1 DNA damage checkpoint	8/365	62/18862	2.475188114789e-05	0.000118963586710796	4.57211781679164e-05	EP300/PRKDC/GADD45A/ATM/CCND1/CDKN1A/BAX/AURKA	8
BP	GO:0009755	hormone-mediated signaling pathway	14/365	193/18862	2.48835253714596e-05	0.000119486579627724	4.59221796087487e-05	ARNTL/PARP1/EP300/CLOCK/KMT2D/PPARA/PPARG/SRC/BRCA1/AR/BMP4/GHRL/CRHR1/ESR2	14
BP	GO:0010256	endomembrane system organization	24/365	482/18862	2.51342213711449e-05	0.000120579756788792	4.63423194946768e-05	ABCD1/PTPRC/HTT/CLN3/SCARB2/VAPB/TARDBP/HUWE1/RTN4/P2RX7/MAPK1/ANK2/MAPK3/SPAST/DMPK/CXCR4/LRRK2/PRKCA/ABCA1/AR/FASLG/ANK3/CLU/CAV1	24
BP	GO:0001678	cellular glucose homeostasis	12/365	145/18862	2.58756695372786e-05	0.000123909656320326	4.76220970633596e-05	XBP1/PIK3R2/IGF1R/ICAM1/GATA4/CFTR/UCP2/AGER/PLA2G6/NGFR/GHRL/HLA-DRB1	12
BP	GO:0038127	ERBB signaling pathway	12/365	145/18862	2.58756695372786e-05	0.000123909656320326	4.76220970633596e-05	MMP9/STUB1/HSP90AA1/RTN4/MAPK1/SRC/EGFR/PRKCA/NRG1/FASLG/AGT/ERBB4	12
BP	GO:0046634	regulation of alpha-beta T cell activation	10/365	101/18862	2.6218916748128e-05	0.000125438583418375	4.82097083668553e-05	PTPRC/GLI3/IL18/HMGB1/AGER/HLA-DRB1/NLRP3/IFNG/SOCS1/SHH	10
BP	GO:0014041	regulation of neuron maturation	4/365	10/18862	2.64157419327028e-05	0.000125919848156436	4.8394672450767e-05	EDNRB/BCL2/MTOR/LRRK2	4
BP	GO:0042045	epithelial fluid transport	4/365	10/18862	2.64157419327028e-05	0.000125919848156436	4.8394672450767e-05	EDNRB/EDN1/CFTR/ITPR1	4
BP	GO:0045793	positive regulation of cell size	4/365	10/18862	2.64157419327028e-05	0.000125919848156436	4.8394672450767e-05	EDN1/AKT3/ATP7A/HSP90AB1	4
BP	GO:0060439	trachea morphogenesis	4/365	10/18862	2.64157419327028e-05	0.000125919848156436	4.8394672450767e-05	MAPK1/MAPK3/BMP4/SHH	4
BP	GO:0003044	regulation of systemic arterial blood pressure mediated by a chemical signal	7/365	46/18862	2.68126884008698e-05	0.000127117401349776	4.88549270919738e-05	EDN1/HSD11B2/AGTR1/ADRB2/AGT/SOD2/MME	7
BP	GO:0031648	protein destabilization	7/365	46/18862	2.68126884008698e-05	0.000127117401349776	4.88549270919738e-05	EP300/HTT/PRKDC/CREBBP/SNCA/SRC/BMP2	7
BP	GO:0048483	autonomic nervous system development	7/365	46/18862	2.68126884008698e-05	0.000127117401349776	4.88549270919738e-05	EDNRB/CTNNB1/NF1/VCAM1/GDNF/NTRK1/FN1	7
BP	GO:0061462	protein localization to lysosome	7/365	46/18862	2.68126884008698e-05	0.000127117401349776	4.88549270919738e-05	SORT1/ATP13A2/SCARB2/RTN4/SORL1/LAMP2/CLU	7
BP	GO:0101023	vascular endothelial cell proliferation	7/365	46/18862	2.68126884008698e-05	0.000127117401349776	4.88549270919738e-05	AKT3/MEF2C/SP1/PPARG/HMGB1/CCL2/GHRL	7
BP	GO:1905562	regulation of vascular endothelial cell proliferation	7/365	46/18862	2.68126884008698e-05	0.000127117401349776	4.88549270919738e-05	AKT3/MEF2C/SP1/PPARG/HMGB1/CCL2/GHRL	7
BP	GO:0045580	regulation of T cell differentiation	12/365	146/18862	2.77103579932462e-05	0.000131254311073892	5.04448622291912e-05	XBP1/PTPRC/GLI3/IL18/HMGB1/CTLA4/BMP4/HLA-DRB1/NLRP3/IFNG/SOCS1/SHH	12
BP	GO:0044783	G1 DNA damage checkpoint	8/365	63/18862	2.78797013412874e-05	0.000131698877996659	5.06157222717083e-05	EP300/PRKDC/GADD45A/ATM/CCND1/CDKN1A/BAX/AURKA	8
BP	GO:0044819	mitotic G1/S transition checkpoint	8/365	63/18862	2.78797013412874e-05	0.000131698877996659	5.06157222717083e-05	EP300/PRKDC/GADD45A/ATM/CCND1/CDKN1A/BAX/AURKA	8
BP	GO:0048662	negative regulation of smooth muscle cell proliferation	8/365	63/18862	2.78797013412874e-05	0.000131698877996659	5.06157222717083e-05	KLF4/MEF2C/PPARG/CDKN1A/IFNG/SOD2/ADIPOQ/IL10	8
BP	GO:0150063	visual system development	20/365	363/18862	2.93594959977033e-05	0.00013856411366274	5.32542326910075e-05	KLF4/BCL2/ATF6/GLI3/NF1/ATF4/MFSD2A/CHD7/SOX2/HMGB1/FASLG/BMP4/BAX/PDGFRB/CYP1A1/VEGFA/FBN1/P2RY12/C3/SHH	20
BP	GO:0010661	positive regulation of muscle cell apoptotic process	6/365	32/18862	2.983942078003e-05	0.000140071325885809	5.38334983343283e-05	ATF4/PPARG/IFNG/SOD2/CAMK2A/CDKN2A	6
BP	GO:0035767	endothelial cell chemotaxis	6/365	32/18862	2.983942078003e-05	0.000140071325885809	5.38334983343283e-05	HSPB1/HMGB1/KDR/NOTCH1/VEGFA/NR4A1	6
BP	GO:0048011	neurotrophin TRK receptor signaling pathway	6/365	32/18862	2.983942078003e-05	0.000140071325885809	5.38334983343283e-05	SORT1/NGF/SRC/NGFR/AGT/NTRK1	6
BP	GO:0098801	regulation of renal system process	6/365	32/18862	2.983942078003e-05	0.000140071325885809	5.38334983343283e-05	EDNRB/EDN1/GJA1/AGTR1/AGT/ADIPOQ	6
BP	GO:1901099	negative regulation of signal transduction in absence of ligand	6/365	32/18862	2.983942078003e-05	0.000140071325885809	5.38334983343283e-05	COL2A1/BCL2/HSPA1B/HSPA1A/TERT/GDNF	6
BP	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	6/365	32/18862	2.983942078003e-05	0.000140071325885809	5.38334983343283e-05	COL2A1/BCL2/HSPA1B/HSPA1A/TERT/GDNF	6
BP	GO:0015872	dopamine transport	7/365	47/18862	3.09863505880613e-05	0.000144935262714846	5.57028512052916e-05	PINK1/SNCA/CXCL12/DRD4/GDNF/CNR1/KCNA2	7
BP	GO:0030574	collagen catabolic process	7/365	47/18862	3.09863505880613e-05	0.000144935262714846	5.57028512052916e-05	MMP9/FURIN/CST3/CTSD/MMP3/MMP2/CTSB	7
BP	GO:0045646	regulation of erythrocyte differentiation	7/365	47/18862	3.09863505880613e-05	0.000144935262714846	5.57028512052916e-05	PRKDC/ETS1/P4HTM/B2M/STAT1/HSPA1B/HSPA1A	7
BP	GO:0070169	positive regulation of biomineral tissue development	7/365	47/18862	3.09863505880613e-05	0.000144935262714846	5.57028512052916e-05	MEF2C/CEBPB/ATF4/P2RX7/ADRB2/BMP4/BMP2	7
BP	GO:0006885	regulation of pH	10/365	103/18862	3.11131082036941e-05	0.000145398221730478	5.58807798658454e-05	EDNRB/EDN1/BCL2/CLN3/MAPK1/MAPK3/SLC9A6/CFTR/LRRK2/FASLG	10
BP	GO:0042093	T-helper cell differentiation	8/365	64/18862	3.13316757818141e-05	0.00014602848712557	5.61230092506415e-05	ATP7A/MTOR/RORA/IL18/HMGB1/IL6/HLA-DRB1/NLRP3	8
BP	GO:0051148	negative regulation of muscle cell differentiation	8/365	64/18862	3.13316757818141e-05	0.00014602848712557	5.61230092506415e-05	XBP1/MECP2/HDAC4/PPARA/DNMT1/NOTCH1/BMP2/SHH	8
BP	GO:0072577	endothelial cell apoptotic process	8/365	64/18862	3.13316757818141e-05	0.00014602848712557	5.61230092506415e-05	ICAM1/KDR/FASLG/CCL2/TERT/SERPINE1/CD40LG/IL10	8
BP	GO:0098727	maintenance of cell number	12/365	148/18862	3.17216433119224e-05	0.00014771448495961	5.67709874218803e-05	KLF4/CTNNB1/SMC1A/MED12/EIF4E/SOX2/NOTCH1/TET1/KIT/IGF1/MYC/CDH2	12
BP	GO:0055006	cardiac cell development	9/365	83/18862	3.21179511478241e-05	0.000149094910023352	5.73015250597562e-05	EDN1/MTOR/GATA4/PPARA/NOTCH1/BMP4/IGF1/PDGFRB/VEGFA	9
BP	GO:0002726	positive regulation of T cell cytokine production	5/365	20/18862	3.22174901101282e-05	0.000149094910023352	5.73015250597562e-05	IL18/IL1R1/B2M/IL6/NLRP3	5
BP	GO:0003323	type B pancreatic cell development	5/365	20/18862	3.22174901101282e-05	0.000149094910023352	5.73015250597562e-05	ARNTL/CLOCK/GSK3B/BMP4/CDH2	5
BP	GO:0010310	regulation of hydrogen peroxide metabolic process	5/365	20/18862	3.22174901101282e-05	0.000149094910023352	5.73015250597562e-05	PINK1/SNCA/MMP3/SOD2/HP	5
BP	GO:0031998	regulation of fatty acid beta-oxidation	5/365	20/18862	3.22174901101282e-05	0.000149094910023352	5.73015250597562e-05	ABCD1/MTOR/MFSD2A/PPARA/CNR1	5
BP	GO:0045056	transcytosis	5/365	20/18862	3.22174901101282e-05	0.000149094910023352	5.73015250597562e-05	LRP2/IGF1R/MFSD2A/SRC/AGER	5
BP	GO:0046697	decidualization	5/365	20/18862	3.22174901101282e-05	0.000149094910023352	5.73015250597562e-05	SPP1/GJA1/MAPK1/MAPK3/GHRL	5
BP	GO:0002456	T cell mediated immunity	10/365	104/18862	3.38400860726515e-05	0.000156189603619275	6.00282228579199e-05	PTPRC/ICAM1/IL18/IL1R1/HMGB1/AGER/B2M/IL6/HLA-DRB1/NLRP3	10
BP	GO:0002821	positive regulation of adaptive immune response	10/365	104/18862	3.38400860726515e-05	0.000156189603619275	6.00282228579199e-05	PTPRC/CD4/IL18/IL1R1/B2M/IL6/HLA-DRB1/NLRP3/PLA2G4A/C3	10
BP	GO:0061387	regulation of extent of cell growth	10/365	104/18862	3.38400860726515e-05	0.000156189603619275	6.00282228579199e-05	SPP1/L1CAM/GSK3B/RTN4/NGF/CDKL5/APOE/CXCL12/VEGFA/FN1	10
BP	GO:2001235	positive regulation of apoptotic signaling pathway	11/365	126/18862	3.41882932978489e-05	0.000157657733146204	6.05924678805373e-05	PTPRC/BCL2/NUPR1/BCL2L11/DDIT3/ATF3/FAS/NGFR/BAX/AGT/CAV1	11
BP	GO:0001818	negative regulation of cytokine production	20/365	367/18862	3.42765891714349e-05	0.000157925763840924	6.06954798986398e-05	KLF4/ABCD1/PTPRC/HSP90AB1/PPARA/DICER1/DDIT3/HMGB1/AGER/FURIN/IL6/GHRL/HLA-DRB1/NLRP3/IFNG/IGF1/ADIPOQ/POMC/FN1/IL10	20
BP	GO:0045058	T cell selection	7/365	48/18862	3.5679757250471e-05	0.000163443355909308	6.28160515541476e-05	PTPRC/CD4/BCL2/GLI3/MTOR/IL6/SHH	7
BP	GO:0110151	positive regulation of biomineralization	7/365	48/18862	3.5679757250471e-05	0.000163443355909308	6.28160515541476e-05	MEF2C/CEBPB/ATF4/P2RX7/ADRB2/BMP4/BMP2	7
BP	GO:1902003	regulation of amyloid-beta formation	7/365	48/18862	3.5679757250471e-05	0.000163443355909308	6.28160515541476e-05	SP1/RTN4/SORL1/APOE/IFNG/IGF1/CLU	7
BP	GO:0014046	dopamine secretion	6/365	33/18862	3.58800947534955e-05	0.000163443355909308	6.28160515541476e-05	PINK1/SNCA/CXCL12/GDNF/CNR1/KCNA2	6
BP	GO:0014059	regulation of dopamine secretion	6/365	33/18862	3.58800947534955e-05	0.000163443355909308	6.28160515541476e-05	PINK1/SNCA/CXCL12/GDNF/CNR1/KCNA2	6
BP	GO:0031112	positive regulation of microtubule polymerization or depolymerization	6/365	33/18862	3.58800947534955e-05	0.000163443355909308	6.28160515541476e-05	OCLN/MECP2/SPAST/HSPA1B/HSPA1A/TRPV4	6
BP	GO:0034368	protein-lipid complex remodeling	6/365	33/18862	3.58800947534955e-05	0.000163443355909308	6.28160515541476e-05	AGTR1/CETP/APOE/LPL/AGT/MPO	6
BP	GO:0034369	plasma lipoprotein particle remodeling	6/365	33/18862	3.58800947534955e-05	0.000163443355909308	6.28160515541476e-05	AGTR1/CETP/APOE/LPL/AGT/MPO	6
BP	GO:0046320	regulation of fatty acid oxidation	6/365	33/18862	3.58800947534955e-05	0.000163443355909308	6.28160515541476e-05	ABCD1/MTOR/MFSD2A/PPARA/PPARG/CNR1	6
BP	GO:0051973	positive regulation of telomerase activity	6/365	33/18862	3.58800947534955e-05	0.000163443355909308	6.28160515541476e-05	KLF4/HSP90AA1/HSP90AB1/MAPK1/MAPK3/MYC	6
BP	GO:0086004	regulation of cardiac muscle cell contraction	6/365	33/18862	3.58800947534955e-05	0.000163443355909308	6.28160515541476e-05	ATP1A1/GATA4/ANK2/RYR2/CAV1/SCN5A	6
BP	GO:0086019	cell-cell signaling involved in cardiac conduction	6/365	33/18862	3.58800947534955e-05	0.000163443355909308	6.28160515541476e-05	GJA1/ANK2/KCNQ1/RYR2/CASQ2/SCN5A	6
BP	GO:1905332	positive regulation of morphogenesis of an epithelium	6/365	33/18862	3.58800947534955e-05	0.000163443355909308	6.28160515541476e-05	GJA1/AR/BMP4/AGT/GDNF/VEGFA	6
BP	GO:0042303	molting cycle	10/365	105/18862	3.67689112010916e-05	0.000167201113142062	6.42602673238704e-05	BCL2/ARNTL/ATP7A/CLOCK/EGFR/NOTCH1/FGFR2/NGFR/TERT/SHH	10
BP	GO:0042633	hair cycle	10/365	105/18862	3.67689112010916e-05	0.000167201113142062	6.42602673238704e-05	BCL2/ARNTL/ATP7A/CLOCK/EGFR/NOTCH1/FGFR2/NGFR/TERT/SHH	10
BP	GO:0006473	protein acetylation	14/365	200/18862	3.69150839313962e-05	0.000167574630786581	6.44038210552775e-05	ARNTL/NUPR1/HCFC1/EP300/CLOCK/MECP2/KMT2A/GSK3B/CREBBP/SNCA/MAPK3/BRCA1/BRCA2/NOS1	14
BP	GO:0050866	negative regulation of cell activation	14/365	200/18862	3.69150839313962e-05	0.000167574630786581	6.44038210552775e-05	GNRH1/PTPRC/CEBPB/GLI3/ATM/HMGB1/CTLA4/APOE/BMP4/HLA-DRB1/SOCS1/CNR1/SHH/IL10	14
BP	GO:0048880	sensory system development	20/365	369/18862	3.70010141592833e-05	0.000167819157807356	6.4497799925559e-05	KLF4/BCL2/ATF6/GLI3/NF1/ATF4/MFSD2A/CHD7/SOX2/HMGB1/FASLG/BMP4/BAX/PDGFRB/CYP1A1/VEGFA/FBN1/P2RY12/C3/SHH	20
BP	GO:0052126	movement in host environment	13/365	175/18862	3.77171887620491e-05	0.000170919277905251	6.56892665520855e-05	CCR5/CD4/DAG1/CTNNB1/SCARB2/ICAM1/SRC/EGFR/CXCR4/HSPA1B/HSPA1A/HLA-DRB1/CAV1	13
BP	GO:0007249	I-kappaB kinase/NF-kappaB signaling	17/365	282/18862	3.81571185470867e-05	0.000172763285878418	6.63979726311078e-05	RPS27A/CD4/NFKBIA/IKBKG/PINK1/BRD4/RORA/TNFRSF1A/HSPB1/GJA1/CD14/FASLG/STAT1/TLR2/HLA-DRB1/TNFSF11/ADIPOQ	17
BP	GO:0016042	lipid catabolic process	19/365	340/18862	3.82886886059152e-05	0.000173209158308868	6.65693344183269e-05	SPP1/CEL/HSD11B1/ABCD1/BSCL2/MTOR/MFSD2A/SORL1/PPARA/PIK3CG/PLA2G6/LEP/ALDH3A2/APOE/LPL/CYP19A1/PLA2G4A/ADIPOQ/CNR1	19
BP	GO:0002793	positive regulation of peptide secretion	12/365	151/18862	3.8682273933729e-05	0.000174838533479393	6.71955508475195e-05	ATP13A2/TARDBP/GJA1/CFTR/EGFR/PLA2G6/TLR2/GHRL/ACSL4/HLA-DRB1/IGF1/TNFSF11	12
BP	GO:0046635	positive regulation of alpha-beta T cell activation	8/365	66/18862	3.93142277673064e-05	0.00017738850701214	6.81755800937592e-05	PTPRC/GLI3/IL18/HLA-DRB1/NLRP3/IFNG/SOCS1/SHH	8
BP	GO:0061515	myeloid cell development	8/365	66/18862	3.93142277673064e-05	0.00017738850701214	6.81755800937592e-05	RPS6/EP300/SRC/KIT/TLR2/APP/TNFSF11/FBN1	8
BP	GO:0010739	positive regulation of protein kinase A signaling	4/365	11/18862	4.08770673975431e-05	0.000183623181275931	7.05717473640578e-05	MIF/ADRB2/ADIPOQ/CALCR	4
BP	GO:0034115	negative regulation of heterotypic cell-cell adhesion	4/365	11/18862	4.08770673975431e-05	0.000183623181275931	7.05717473640578e-05	KLF4/IL1RN/ADIPOQ/IL10	4
BP	GO:0070587	regulation of cell-cell adhesion involved in gastrulation	4/365	11/18862	4.08770673975431e-05	0.000183623181275931	7.05717473640578e-05	KLF4/IL1RN/ADIPOQ/IL10	4
BP	GO:0071492	cellular response to UV-A	4/365	11/18862	4.08770673975431e-05	0.000183623181275931	7.05717473640578e-05	MMP9/MMP3/MMP2/MME	4
BP	GO:0097104	postsynaptic membrane assembly	4/365	11/18862	4.08770673975431e-05	0.000183623181275931	7.05717473640578e-05	CEL/NLGN3/CDH2/NRXN1	4
BP	GO:0021879	forebrain neuron differentiation	7/365	49/18862	4.09415843616759e-05	0.000183623181275931	7.05717473640578e-05	ATP7A/B2M/FGFR2/DLX5/SATB2/FOXG1/ERBB4	7
BP	GO:0046638	positive regulation of alpha-beta T cell differentiation	7/365	49/18862	4.09415843616759e-05	0.000183623181275931	7.05717473640578e-05	GLI3/IL18/HLA-DRB1/NLRP3/IFNG/SOCS1/SHH	7
BP	GO:0002697	regulation of immune effector process	23/365	465/18862	4.10776693003485e-05	0.000184075788628445	7.07456975783759e-05	XBP1/PTPRC/STXBP1/PRKDC/HSP90AA1/ICAM1/IL18/IL1R1/HMGB1/AGER/LEP/B2M/IL6/STAT1/C4A/HLA-DRB1/NLRP3/IFNG/CLU/NOS2/C3/CD40LG/IL10	23
BP	GO:0002053	positive regulation of mesenchymal cell proliferation	5/365	21/18862	4.16170452534166e-05	0.000185381799877772	7.12476358157035e-05	FGFR2/STAT1/MYC/VEGFA/SHH	5
BP	GO:0010875	positive regulation of cholesterol efflux	5/365	21/18862	4.16170452534166e-05	0.000185381799877772	7.12476358157035e-05	NFKBIA/APOE/ABCA1/ADIPOQ/CAV1	5
BP	GO:0032516	positive regulation of phosphoprotein phosphatase activity	5/365	21/18862	4.16170452534166e-05	0.000185381799877772	7.12476358157035e-05	PTPRC/MTOR/HSP90AB1/PPP1R15A/PDGFRB	5
BP	GO:0035929	steroid hormone secretion	5/365	21/18862	4.16170452534166e-05	0.000185381799877772	7.12476358157035e-05	AGTR1/GHRL/AGT/POMC/CRHR1	5
BP	GO:0043555	regulation of translation in response to stress	5/365	21/18862	4.16170452534166e-05	0.000185381799877772	7.12476358157035e-05	EIF2AK2/RPS6KA3/DNAJC3/ATF4/PPP1R15A	5
BP	GO:0061042	vascular wound healing	5/365	21/18862	4.16170452534166e-05	0.000185381799877772	7.12476358157035e-05	XBP1/CXCR4/KDR/SERPINE1/VEGFA	5
BP	GO:1903429	regulation of cell maturation	5/365	21/18862	4.16170452534166e-05	0.000185381799877772	7.12476358157035e-05	EDNRB/BCL2/MTOR/LRRK2/AURKA	5
BP	GO:0050714	positive regulation of protein secretion	11/365	129/18862	4.25186350783422e-05	0.000189236850340173	7.27292442129538e-05	ATP13A2/TARDBP/GJA1/CFTR/EGFR/PLA2G6/TLR2/GHRL/ACSL4/HLA-DRB1/IGF1	11
BP	GO:0043276	anoikis	6/365	34/18862	4.28637203036859e-05	0.00019044882179074	7.3195040211191e-05	BCL2/IKBKG/MTOR/SRC/NOTCH1/CAV1	6
BP	GO:1903514	release of sequestered calcium ion into cytosol by endoplasmic reticulum	6/365	34/18862	4.28637203036859e-05	0.00019044882179074	7.3195040211191e-05	CCR5/ANK2/CHD7/FASLG/RYR2/CASQ2	6
BP	GO:0048640	negative regulation of developmental growth	10/365	107/18862	4.32810535536496e-05	0.000192139978201698	7.38450009740854e-05	SPP1/RAI1/RTN4/GJA1/PPARA/ADRB2/CDKN1A/BMP4/GDF15/SLC6A4	10
BP	GO:1902905	positive regulation of supramolecular fiber organization	14/365	203/18862	4.34659200407854e-05	0.000192797140248704	7.40975675271552e-05	OCLN/EDN1/MTOR/MECP2/ICAM1/SPAST/APOE/HSPA1B/HSPA1A/CSF3/APP/CLU/NOX4/TRPV4	14
BP	GO:0046637	regulation of alpha-beta T cell differentiation	8/365	67/18862	4.39016329672717e-05	0.00019456490004293	7.4776969205808e-05	GLI3/IL18/HMGB1/HLA-DRB1/NLRP3/IFNG/SOCS1/SHH	8
BP	GO:0071326	cellular response to monosaccharide stimulus	11/365	130/18862	4.56582145740968e-05	0.000202178591438936	7.77031330048081e-05	XBP1/IGF1R/ICAM1/GATA4/CFTR/UCP2/AGER/PLA2G6/LEP/GHRL/HLA-DRB1	11
BP	GO:0045088	regulation of innate immune response	18/365	315/18862	4.57765301718953e-05	0.00020253115715951	7.78386343003887e-05	MATR3/CCL5/IKBKG/HRAS/EP300/PRKDC/HSP90AA1/XIAP/HSP90AB1/CREBBP/PPARG/SRC/HMGB1/LEP/APOE/STAT1/IFNG/SOCS1	18
BP	GO:0045912	negative regulation of carbohydrate metabolic process	7/365	50/18862	4.68235189807692e-05	0.00020633640170938	7.9301100831934e-05	NUPR1/EP300/GSK3B/HDAC4/PPARA/LEPR/ADIPOQ	7
BP	GO:1904036	negative regulation of epithelial cell apoptotic process	7/365	50/18862	4.68235189807692e-05	0.00020633640170938	7.9301100831934e-05	NUPR1/MTOR/ICAM1/PPARA/KDR/TERT/SERPINE1	7
BP	GO:0002028	regulation of sodium ion transport	9/365	87/18862	4.68337113547465e-05	0.00020633640170938	7.9301100831934e-05	NEDD4L/ATP1A1/P2RX7/ADRB2/DMPK/ANK3/DRD4/SCN5A/NOS1	9
BP	GO:0099175	regulation of postsynapse organization	9/365	87/18862	4.68337113547465e-05	0.00020633640170938	7.9301100831934e-05	CDKL5/LRRK2/APOE/GHRL/IL1RAPL1/CDH2/ADAM10/GRIN2B/RELN	9
BP	GO:1904063	negative regulation of cation transmembrane transport	9/365	87/18862	4.68337113547465e-05	0.00020633640170938	7.9301100831934e-05	MMP9/NEDD4L/ATP7A/ANK3/DRD4/CASQ2/CRHR1/CAV1/KCNH2	9
BP	GO:0006641	triglyceride metabolic process	10/365	108/18862	4.68902202791877e-05	0.000206411617276088	7.93300083692865e-05	MFSD2A/SORL1/CYP2E1/PIK3CG/CETP/APOE/ACSL4/LPL/CAV1/C3	10
BP	GO:0001906	cell killing	13/365	179/18862	4.7707850501361e-05	0.000209658177602119	8.05777562491501e-05	PTPRC/HSP90AB1/P2RX7/ICAM1/IL18/BCL2L11/AGER/LEP/B2M/HLA-DRB1/IFNG/NOS2/C3	13
BP	GO:0007369	gastrulation	13/365	179/18862	4.7707850501361e-05	0.000209658177602119	8.05777562491501e-05	MMP9/KLF4/DAG1/RPS6/GJA1/SOX2/IL1RN/FGFR2/BMP4/MMP2/ADIPOQ/FN1/IL10	13
BP	GO:0007004	telomere maintenance via telomerase	8/365	68/18862	4.89269346114647e-05	0.000214655134749712	8.24982327105564e-05	HSP90AA1/HSP90AB1/HNRNPA1/MAPK1/ATM/MAPK3/SRC/TERT	8
BP	GO:0051937	catecholamine transport	8/365	68/18862	4.89269346114647e-05	0.000214655134749712	8.24982327105564e-05	PINK1/SNCA/CXCL12/DRD4/GDNF/CNR1/KCNA2/P2RY12	8
BP	GO:0006813	potassium ion transport	15/365	232/18862	4.9191186802154e-05	0.000215633728410782	8.28743348134677e-05	NPPA/NEDD4L/ATP1A1/ATF4/ANK2/SLC9A6/ANK3/KCNQ1/CASQ2/KCNA2/CAV1/KCNH2/P2RY12/NOS1/KCNQ2	15
BP	GO:1901800	positive regulation of proteasomal protein catabolic process	10/365	109/18862	5.07529632721879e-05	0.000222107867697852	8.53625354806822e-05	NUPR1/STUB1/GSK3B/UBQLN2/LRRK2/HSPA1B/HSPA1A/CLU/AURKA/CAV1	10
BP	GO:1904659	glucose transmembrane transport	10/365	109/18862	5.07529632721879e-05	0.000222107867697852	8.53625354806822e-05	OCLN/SORT1/EDN1/SLC2A1/LEP/TERT/IGF1/SLC2A4/ADIPOQ/C3	10
BP	GO:0034367	protein-containing complex remodeling	6/365	35/18862	5.08953015321934e-05	0.000222544701937761	8.55304236275088e-05	AGTR1/CETP/APOE/LPL/AGT/MPO	6
BP	GO:0010232	vascular transport	9/365	88/18862	5.1292759977456e-05	0.000223721921435004	8.59828634358933e-05	LRP2/MFSD2A/GJA1/AGER/SLC2A1/APOE/LEPR/SLC2A4/SLC6A1	9
BP	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	9/365	88/18862	5.1292759977456e-05	0.000223721921435004	8.59828634358933e-05	STUB1/GSK3B/UBQLN2/LRRK2/HSPA1B/HSPA1A/CLU/AURKA/CAV1	9
BP	GO:0045582	positive regulation of T cell differentiation	9/365	88/18862	5.1292759977456e-05	0.000223721921435004	8.59828634358933e-05	XBP1/PTPRC/GLI3/IL18/HLA-DRB1/NLRP3/IFNG/SOCS1/SHH	9
BP	GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	11/365	132/18862	5.25395861538676e-05	0.000228969353812942	8.79996048381095e-05	STUB1/HSP90AB1/GSK3B/UBQLN2/LRRK2/HSPA1B/HSPA1A/CLU/AURKA/CAV1/SHH	11
BP	GO:0014821	phasic smooth muscle contraction	5/365	22/18862	5.30064018526518e-05	0.000230428162206628	8.85602674771967e-05	EDNRB/EDN1/KIT/GHRL/GDNF	5
BP	GO:0051131	chaperone-mediated protein complex assembly	5/365	22/18862	5.30064018526518e-05	0.000230428162206628	8.85602674771967e-05	STUB1/HSP90AA1/HSP90AB1/HSPA1A/CLU	5
BP	GO:2000648	positive regulation of stem cell proliferation	5/365	22/18862	5.30064018526518e-05	0.000230428162206628	8.85602674771967e-05	PTPRC/GJA1/KITLG/EPCAM/TERT	5
BP	GO:0042733	embryonic digit morphogenesis	7/365	51/18862	5.33803360426995e-05	0.000231861144271775	8.91110043045195e-05	GLI3/CREBBP/BCL2L11/NOTCH1/BMP4/BAX/SHH	7
BP	GO:0003208	cardiac ventricle morphogenesis	8/365	69/18862	5.44224983126033e-05	0.000235996152583402	9.07002086734268e-05	LRP2/MEF2C/GATA4/CHD7/NRG1/NOTCH1/FGFR2/RYR2	8
BP	GO:0021675	nerve development	8/365	69/18862	5.44224983126033e-05	0.000235996152583402	9.07002086734268e-05	DAG1/GLI3/NGF/CHD7/DICER1/VCAM1/NGFR/NTRK1	8
BP	GO:0045727	positive regulation of translation	11/365	133/18862	5.63020693639242e-05	0.000243944562128128	9.37550144252867e-05	CCL5/PINK1/AGO2/DNAJC3/PRKDC/RPL5/MTOR/MAPK1/MAPK3/IL6/PPP1R15A	11
BP	GO:0002695	negative regulation of leukocyte activation	13/365	182/18862	5.66425639980581e-05	0.000245088453161794	9.41946451324716e-05	GNRH1/PTPRC/CEBPB/GLI3/ATM/HMGB1/CTLA4/BMP4/HLA-DRB1/SOCS1/CNR1/SHH/IL10	13
BP	GO:0002706	regulation of lymphocyte mediated immunity	12/365	157/18862	5.66597302876903e-05	0.000245088453161794	9.41946451324716e-05	PTPRC/IL18/IL1R1/HMGB1/AGER/LEP/B2M/IL6/HLA-DRB1/NLRP3/C3/IL10	12
BP	GO:0071675	regulation of mononuclear cell migration	10/365	111/18862	5.92972484272577e-05	0.000256074090980418	9.84167463474809e-05	CCL5/MAPK1/MAPK3/HMGB1/AGER/CXCL12/CCL2/APP/SERPINE1/ADAM10	10
BP	GO:1903959	regulation of anion transmembrane transport	10/365	111/18862	5.92972484272577e-05	0.000256074090980418	9.84167463474809e-05	OCLN/EDN1/MTOR/CFTR/SLC2A1/LEP/TERT/IGF1/ADIPOQ/C3	10
BP	GO:0042311	vasodilation	6/365	36/18862	6.00868057096739e-05	0.000259269860745617	9.96449739325611e-05	NPPA/EDNRB/ADRB2/APOE/SOD2/NOS1	6
BP	GO:0043401	steroid hormone mediated signaling pathway	11/365	134/18862	6.02935484513862e-05	0.000259434421266618	9.9708219343263e-05	ARNTL/PARP1/EP300/CLOCK/KMT2D/PPARA/SRC/BRCA1/AR/BMP4/ESR2	11
BP	GO:0060601	lateral sprouting from an epithelium	4/365	12/18862	6.03806016019213e-05	0.000259434421266618	9.9708219343263e-05	AR/FGFR2/BMP4/SHH	4
BP	GO:0070586	cell-cell adhesion involved in gastrulation	4/365	12/18862	6.03806016019213e-05	0.000259434421266618	9.9708219343263e-05	KLF4/IL1RN/ADIPOQ/IL10	4
BP	GO:0071872	cellular response to epinephrine stimulus	4/365	12/18862	6.03806016019213e-05	0.000259434421266618	9.9708219343263e-05	SNCA/KCNQ1/RYR2/ADIPOQ	4
BP	GO:0045123	cellular extravasation	8/365	70/18862	6.04223461069941e-05	0.000259434421266618	9.9708219343263e-05	ICAM1/PIK3CG/IL1R1/AGER/VCAM1/LEP/CXCL12/CCL2	8
BP	GO:1904427	positive regulation of calcium ion transmembrane transport	8/365	70/18862	6.04223461069941e-05	0.000259434421266618	9.9708219343263e-05	PLP1/HTT/SNCA/ANK2/BAX/RYR2/GJC2/CALCR	8
BP	GO:0002711	positive regulation of T cell mediated immunity	7/365	52/18862	6.06699717847107e-05	0.000259645651938819	9.97894014550778e-05	PTPRC/IL18/IL1R1/B2M/IL6/HLA-DRB1/NLRP3	7
BP	GO:0035196	production of miRNAs involved in gene silencing by miRNA	7/365	52/18862	6.06699717847107e-05	0.000259645651938819	9.97894014550778e-05	AGO1/AGO2/DICER1/EGFR/IL6/BMP4/TERT	7
BP	GO:0050433	regulation of catecholamine secretion	7/365	52/18862	6.06699717847107e-05	0.000259645651938819	9.97894014550778e-05	PINK1/SNCA/CXCL12/GDNF/CNR1/KCNA2/P2RY12	7
BP	GO:0050999	regulation of nitric-oxide synthase activity	7/365	52/18862	6.06699717847107e-05	0.000259645651938819	9.97894014550778e-05	HSP90AA1/EGFR/LEP/APOE/TERT/CNR1/CAV1	7
BP	GO:0035303	regulation of dephosphorylation	14/365	210/18862	6.28435321339491e-05	0.000268727979729648	0.000103280005080819	PTPRC/EIF2AK2/MEF2C/PINK1/HTT/MTOR/HSP90AB1/GSK3B/SRC/DMPK/PPP1R15A/IFNG/PDGFRB/BMP2	14
BP	GO:0008645	hexose transmembrane transport	10/365	112/18862	6.40093503072722e-05	0.000272821611977413	0.000104853307420879	OCLN/SORT1/EDN1/SLC2A1/LEP/TERT/IGF1/SLC2A4/ADIPOQ/C3	10
BP	GO:0030278	regulation of ossification	10/365	112/18862	6.40093503072722e-05	0.000272821611977413	0.000104853307420879	BCL2/MEF2C/P2RX7/MAPK1/MAPK3/ADRB2/NOTCH1/BGLAP/BMP4/BMP2	10
BP	GO:0030326	embryonic limb morphogenesis	10/365	112/18862	6.40093503072722e-05	0.000272821611977413	0.000104853307420879	CTNNB1/GLI3/CREBBP/CHD7/BCL2L11/NOTCH1/DLX5/BMP4/BAX/SHH	10
BP	GO:0035113	embryonic appendage morphogenesis	10/365	112/18862	6.40093503072722e-05	0.000272821611977413	0.000104853307420879	CTNNB1/GLI3/CREBBP/CHD7/BCL2L11/NOTCH1/DLX5/BMP4/BAX/SHH	10
BP	GO:0002021	response to dietary excess	5/365	23/18862	6.66607331188266e-05	0.000282511965298736	0.00010857759300241	SORL1/ADRB2/LEP/APOE/GDF15	5
BP	GO:0006622	protein targeting to lysosome	5/365	23/18862	6.66607331188266e-05	0.000282511965298736	0.00010857759300241	SORT1/SCARB2/SORL1/LAMP2/CLU	5
BP	GO:0010738	regulation of protein kinase A signaling	5/365	23/18862	6.66607331188266e-05	0.000282511965298736	0.00010857759300241	MIF/ADRB2/LRRK2/ADIPOQ/CALCR	5
BP	GO:0019430	removal of superoxide radicals	5/365	23/18862	6.66607331188266e-05	0.000282511965298736	0.00010857759300241	ATP7A/PRDX1/SOD2/NQO1/MPO	5
BP	GO:0033032	regulation of myeloid cell apoptotic process	5/365	23/18862	6.66607331188266e-05	0.000282511965298736	0.00010857759300241	BCL2/MEF2C/KITLG/ADIPOQ/CDKN2A	5
BP	GO:0036499	PERK-mediated unfolded protein response	5/365	23/18862	6.66607331188266e-05	0.000282511965298736	0.00010857759300241	ATF4/DDIT3/ATF3/CCL2/PPP1R15A	5
BP	GO:1904385	cellular response to angiotensin	5/365	23/18862	6.66607331188266e-05	0.000282511965298736	0.00010857759300241	ARID1B/AGTR1/SRC/CAMK2A/CAV1	5
BP	GO:0106027	neuron projection organization	9/365	91/18862	6.68766507205886e-05	0.000283022776935295	0.000108773912821702	ABCD1/IGF1R/GSK3B/LRRK2/APOE/APP/ADAM10/GRIN2B/RELN	9
BP	GO:0046579	positive regulation of Ras protein signal transduction	8/365	71/18862	6.69621972309707e-05	0.000283022776935295	0.000108773912821702	HRAS/NGF/PIK3CG/NOTCH1/KITLG/IGF1/PDGFRB/NTRK1	8
BP	GO:0010565	regulation of cellular ketone metabolic process	13/365	185/18862	6.69975583918284e-05	0.000283022776935295	0.000108773912821702	ABCD1/CLN3/MTOR/MFSD2A/PPARA/PPARG/BRCA1/ADIPOQ/CNR1/EGR1/CAV1/BMP2/NQO1	13
BP	GO:0038061	NIK/NF-kappaB signaling	13/365	185/18862	6.69975583918284e-05	0.000283022776935295	0.000108773912821702	EDN1/NFKBIA/EIF2AK2/EP300/IL18/CD14/DICER1/EGFR/HMGB1/AGER/TLR2/APP/NLRP3	13
BP	GO:0050432	catecholamine secretion	7/365	53/18862	6.87535936475063e-05	0.00028973937934867	0.000111355299144321	PINK1/SNCA/CXCL12/GDNF/CNR1/KCNA2/P2RY12	7
BP	GO:0071320	cellular response to cAMP	7/365	53/18862	6.87535936475063e-05	0.00028973937934867	0.000111355299144321	PIK3CG/CFTR/AHR/KCNQ1/APP/ADIPOQ/NOX4	7
BP	GO:1905517	macrophage migration	7/365	53/18862	6.87535936475063e-05	0.00028973937934867	0.000111355299144321	EDNRB/CCL5/MIF/MAPK1/MAPK3/CCL2/P2RY12	7
BP	GO:0006638	neutral lipid metabolic process	11/365	136/18862	6.90093816363912e-05	0.000290229200882182	0.000111543551854444	MFSD2A/SORL1/CYP2E1/PIK3CG/CETP/APOE/ACSL4/LPL/PLA2G4A/CAV1/C3	11
BP	GO:0006639	acylglycerol metabolic process	11/365	136/18862	6.90093816363912e-05	0.000290229200882182	0.000111543551854444	MFSD2A/SORL1/CYP2E1/PIK3CG/CETP/APOE/ACSL4/LPL/PLA2G4A/CAV1/C3	11
BP	GO:0030282	bone mineralization	10/365	113/18862	6.90361778942141e-05	0.000290229200882182	0.000111543551854444	MEF2C/ATF4/P2RX7/ADRB2/LEP/FGFR2/BGLAP/BMP4/IGF1/BMP2	10
BP	GO:0001941	postsynaptic membrane organization	6/365	37/18862	7.0557263990156e-05	0.000295673914911511	0.000113636114352693	CEL/APOE/NLGN3/GDNF/CDH2/NRXN1	6
BP	GO:0010613	positive regulation of cardiac muscle hypertrophy	6/365	37/18862	7.0557263990156e-05	0.000295673914911511	0.000113636114352693	EDN1/PARP1/MTOR/PRKCA/IGF1/AGT	6
BP	GO:0099622	cardiac muscle cell membrane repolarization	6/365	37/18862	7.0557263990156e-05	0.000295673914911511	0.000113636114352693	NPPA/ATP1A1/ANK2/KCNQ1/KCNH2/SCN5A	6
BP	GO:1903115	regulation of actin filament-based movement	6/365	37/18862	7.0557263990156e-05	0.000295673914911511	0.000113636114352693	ATP1A1/GATA4/ANK2/RYR2/CAV1/SCN5A	6
BP	GO:0007219	Notch signaling pathway	13/365	186/18862	7.07962251978164e-05	0.000296437954148297	0.000113929756928865	NFKBIA/PSEN2/EP300/CREBBP/SRC/EGFR/NOTCH1/STAT1/KIT/APP/MYC/ADAM10/BMP2	13
BP	GO:0000723	telomere maintenance	12/365	161/18862	7.23114172900623e-05	0.000302298688575229	0.000116182208206919	PARP1/PRKDC/HSP90AA1/HSP90AB1/HNRNPA1/MAPK1/ATM/MAPK3/SRC/BRCA2/TERT/MYC	12
BP	GO:2000058	regulation of ubiquitin-dependent protein catabolic process	12/365	161/18862	7.23114172900623e-05	0.000302298688575229	0.000116182208206919	STUB1/RPL5/HSP90AB1/GSK3B/UBQLN2/LRRK2/HSPA1B/HSPA1A/CLU/AURKA/CAV1/SHH	12
BP	GO:0030316	osteoclast differentiation	9/365	92/18862	7.28838463488265e-05	0.000304448564876104	0.000117008468410642	CEBPB/MTOR/SRC/FOS/TF/BGLAP/IFNG/TNFSF11/FBN1	9
BP	GO:0046394	carboxylic acid biosynthetic process	18/365	327/18862	7.40769753412365e-05	0.000308703936870695	0.000118643932055567	XBP1/CBS/PLP1/ABCD1/EDN1/MIF/PTGS1/CLN3/MTR/CYP2D6/CYP2E1/BRCA1/MTHFR/GSTM1/LPL/PLA2G4A/ADIPOQ/CYP1A1	18
BP	GO:0035924	cellular response to vascular endothelial growth factor stimulus	8/365	72/18862	7.40795079689706e-05	0.000308703936870695	0.000118643932055567	HSPB1/VCAM1/KDR/NOTCH1/PDGFRB/VEGFA/NR4A1/XDH	8
BP	GO:1903036	positive regulation of response to wounding	8/365	72/18862	7.40795079689706e-05	0.000308703936870695	0.000118643932055567	XBP1/OCLN/HRAS/ATP7A/MTOR/HMGB1/CXCR4/SERPINE1	8
BP	GO:0015749	monosaccharide transmembrane transport	10/365	114/18862	7.43946030254342e-05	0.000309770367728817	0.000119053792556718	OCLN/SORT1/EDN1/SLC2A1/LEP/TERT/IGF1/SLC2A4/ADIPOQ/C3	10
BP	GO:0002831	regulation of response to biotic stimulus	21/365	420/18862	7.60013259517859e-05	0.000316209014333583	0.000121528352350316	MATR3/CCL5/IKBKG/HRAS/EP300/PRKDC/HSP90AA1/XIAP/HSP90AB1/CREBBP/MAPK3/PPARG/SRC/HMGB1/LEP/APOE/PRKCA/STAT1/HLA-DRB1/IFNG/SOCS1	21
BP	GO:0061756	leukocyte adhesion to vascular endothelial cell	7/365	54/18862	7.76956665013728e-05	0.000323001682659401	0.00012413897302297	KLF4/ICAM1/ETS1/VCAM1/LEP/IL6/CXCL12	7
BP	GO:0071322	cellular response to carbohydrate stimulus	11/365	138/18862	7.87831746563514e-05	0.00032726280646932	0.000125776647258386	XBP1/IGF1R/ICAM1/GATA4/CFTR/UCP2/AGER/PLA2G6/LEP/GHRL/HLA-DRB1	11
BP	GO:0060491	regulation of cell projection assembly	13/365	188/18862	7.89573964104072e-05	0.000327726417773252	0.00012595482661237	OCLN/HRAS/HTT/ATP7A/MTOR/P2RX7/HDAC4/ICAM1/SRC/CDKL5/KIT/CAV1/P2RY12	13
BP	GO:0010948	negative regulation of cell cycle process	19/365	359/18862	7.92593624893612e-05	0.000328719099262533	0.000126336343078797	KLF4/MIF/BCL2/EP300/PRKDC/HSP90AB1/RAD21/GADD45A/ATM/BRCA1/CCND1/CDKN1A/BMP4/CCL2/BAX/AURKA/ADAM10/GJC2/CDKN2A	19
BP	GO:0003206	cardiac chamber morphogenesis	10/365	115/18862	8.01021611812208e-05	0.000331688854131732	0.000127477706543399	LRP2/MEF2C/GATA4/CHD7/NRG1/NOTCH1/FGFR2/BMP4/RYR2/BMP2	10
BP	GO:0030004	cellular monovalent inorganic cation homeostasis	10/365	115/18862	8.01021611812208e-05	0.000331688854131732	0.000127477706543399	BCL2/NEDD4L/ATP1A1/CLN3/MAPK1/MAPK3/SLC9A6/CFTR/LRRK2/FASLG	10
BP	GO:0003151	outflow tract morphogenesis	8/365	73/18862	8.18135105038837e-05	0.000337174735415218	0.000129586090818833	LRP2/MEF2C/CTNNB1/NOTCH1/ELN/FGFR2/BMP4/VEGFA	8
BP	GO:0033077	T cell differentiation in thymus	8/365	73/18862	8.18135105038837e-05	0.000337174735415218	0.000129586090818833	PTPRC/BCL2/RPS6/PRKDC/GLI3/B2M/BMP4/SHH	8
BP	GO:0033143	regulation of intracellular steroid hormone receptor signaling pathway	8/365	73/18862	8.18135105038837e-05	0.000337174735415218	0.000129586090818833	ARNTL/PARP1/EP300/CLOCK/KMT2D/SRC/BRCA1/AR	8
BP	GO:0060193	positive regulation of lipase activity	8/365	73/18862	8.18135105038837e-05	0.000337174735415218	0.000129586090818833	CCL5/HRAS/AGTR1/EGFR/FGFR2/KIT/PDGFRB/P2RY12	8
BP	GO:0072401	signal transduction involved in DNA integrity checkpoint	8/365	73/18862	8.18135105038837e-05	0.000337174735415218	0.000129586090818833	EP300/PRKDC/GADD45A/ATM/BRCA1/CDKN1A/BAX/AURKA	8
BP	GO:0072422	signal transduction involved in DNA damage checkpoint	8/365	73/18862	8.18135105038837e-05	0.000337174735415218	0.000129586090818833	EP300/PRKDC/GADD45A/ATM/BRCA1/CDKN1A/BAX/AURKA	8
BP	GO:0014742	positive regulation of muscle hypertrophy	6/365	38/18862	8.24328563813795e-05	0.000338394957098149	0.000130055057622139	EDN1/PARP1/MTOR/PRKCA/IGF1/AGT	6
BP	GO:0038179	neurotrophin signaling pathway	6/365	38/18862	8.24328563813795e-05	0.000338394957098149	0.000130055057622139	SORT1/NGF/SRC/NGFR/AGT/NTRK1	6
BP	GO:0042417	dopamine metabolic process	6/365	38/18862	8.24328563813795e-05	0.000338394957098149	0.000130055057622139	MAOA/ATP7A/SNCA/DRD4/GRIN2A/DBH	6
BP	GO:0048246	macrophage chemotaxis	6/365	38/18862	8.24328563813795e-05	0.000338394957098149	0.000130055057622139	EDNRB/CCL5/MIF/MAPK1/MAPK3/CCL2	6
BP	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	6/365	38/18862	8.24328563813795e-05	0.000338394957098149	0.000130055057622139	MEF2C/PPARG/CDKN1A/SOD2/ADIPOQ/IL10	6
BP	GO:0018205	peptidyl-lysine modification	20/365	391/18862	8.25120242319531e-05	0.000338454494380911	0.000130077939537421	HCFC1/CTNNB1/NSD1/EP300/ATP7A/CLOCK/MECP2/KMT2A/CREBBP/BRD4/KMT2D/HDAC4/KMT2C/SNCA/MAPK3/DNMT1/BRCA1/BRCA2/EGR1/NOS1	20
BP	GO:0001963	synaptic transmission, dopaminergic	5/365	24/18862	8.28738043002664e-05	0.000338876165396558	0.000130240000014646	PINK1/SNCA/DRD4/GDNF/SLC6A4	5
BP	GO:0002407	dendritic cell chemotaxis	5/365	24/18862	8.28738043002664e-05	0.000338876165396558	0.000130240000014646	CCR5/CCL5/PIK3CG/HMGB1/CXCR4	5
BP	GO:0003309	type B pancreatic cell differentiation	5/365	24/18862	8.28738043002664e-05	0.000338876165396558	0.000130240000014646	ARNTL/CLOCK/GSK3B/BMP4/CDH2	5
BP	GO:0044321	response to leptin	5/365	24/18862	8.28738043002664e-05	0.000338876165396558	0.000130240000014646	LRP2/EDN1/CCND1/LEP/LEPR	5
BP	GO:0071287	cellular response to manganese ion	4/365	13/18862	8.58872925942994e-05	0.000350650615786711	0.000134765264921345	ATP13A2/ATF4/LRRK2/APP	4
BP	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response	4/365	13/18862	8.58872925942994e-05	0.000350650615786711	0.000134765264921345	XBP1/ATF6/BCL2L11/BAX	4
BP	GO:0034219	carbohydrate transmembrane transport	10/365	116/18862	8.61770663001991e-05	0.000351103026617897	0.000134939139606782	OCLN/SORT1/EDN1/SLC2A1/LEP/TERT/IGF1/SLC2A4/ADIPOQ/C3	10
BP	GO:0042632	cholesterol homeostasis	9/365	94/18862	8.62664295434878e-05	0.000351103026617897	0.000134939139606782	XBP1/RORA/IL18/CETP/GRAMD1B/APOE/ABCA1/LPL/CAV1	9
BP	GO:0050764	regulation of phagocytosis	9/365	94/18862	8.62664295434878e-05	0.000351103026617897	0.000134939139606782	PTPRC/PPARG/HMGB1/C4A/CCL2/TLR2/IFNG/ADIPOQ/C3	9
BP	GO:0070167	regulation of biomineral tissue development	9/365	94/18862	8.62664295434878e-05	0.000351103026617897	0.000134939139606782	MEF2C/CEBPB/ATF4/P2RX7/ADRB2/NOTCH1/BGLAP/BMP4/BMP2	9
BP	GO:0001755	neural crest cell migration	7/365	55/18862	8.75640150590643e-05	0.000356107268701742	0.000136862415881791	EDNRB/KITLG/BMP4/GDNF/FN1/SHH/ERBB4	7
BP	GO:0006694	steroid biosynthetic process	13/365	190/18862	8.79215865772144e-05	0.000357283838622003	0.000137314606038784	HSD11B1/ATP1A1/SP1/HSD11B2/CFTR/LEP/APOE/IFNG/CYP19A1/CYP1A1/CYP17A1/EGR1/BMP2	13
BP	GO:0035148	tube formation	11/365	140/18862	8.97181386574223e-05	0.000364019176537169	0.000139903192961513	LRP2/MED12/DICER1/BCL2L11/MTHFR/NOTCH1/FGFR2/BMP4/GDNF/VEGFA/SHH	11
BP	GO:0046718	viral entry into host cell	11/365	140/18862	8.97181386574223e-05	0.000364019176537169	0.000139903192961513	CCR5/CD4/DAG1/SCARB2/ICAM1/EGFR/CXCR4/HSPA1B/HSPA1A/HLA-DRB1/CAV1	11
BP	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	21/365	425/18862	8.97939351354076e-05	0.000364044505421165	0.000139912927590822	RPS27A/ARNTL/NEDD4L/CTNNB1/STUB1/CLOCK/HSP90AB1/GSK3B/HUWE1/UBE2J1/UBQLN2/DDIT3/LRRK2/DNAJC10/HSPA1B/HSPA1A/CLU/AURKA/CAV1/UCHL1/SHH	21
BP	GO:0046323	glucose import	8/365	74/18862	9.02052507023045e-05	0.000365429010972029	0.000140445033478983	OCLN/SORT1/SLC2A1/LEP/TERT/IGF1/SLC2A4/ADIPOQ	8
BP	GO:0016125	sterol metabolic process	12/365	165/18862	9.15581374628889e-05	0.000370622808569807	0.000142441161469924	CEL/SP1/CYP2D6/NFE2L1/CETP/CFTR/LEP/APOE/ABCA1/APP/LEPR/CYP19A1	12
BP	GO:0051963	regulation of synapse assembly	9/365	95/18862	9.36953207487125e-05	0.000378688269342673	0.000145540953424743	MEF2C/SNCA/NLGN3/TLR2/GHRL/APP/IL1RAPL1/NTRK1/NRXN1	9
BP	GO:0090277	positive regulation of peptide hormone secretion	9/365	95/18862	9.36953207487125e-05	0.000378688269342673	0.000145540953424743	TARDBP/GJA1/CFTR/EGFR/PLA2G6/GHRL/ACSL4/HLA-DRB1/TNFSF11	9
BP	GO:0072210	metanephric nephron development	6/365	39/18862	9.58469810210244e-05	0.000386787277304581	0.000148653638543341	STAT1/BMP4/PDGFRB/GDNF/ADIPOQ/EGR1	6
BP	GO:2000279	negative regulation of DNA biosynthetic process	6/365	39/18862	9.58469810210244e-05	0.000386787277304581	0.000148653638543341	HNRNPA1/GJA1/PPARG/SRC/CDKN1A/ADIPOQ	6
BP	GO:0031050	dsRNA processing	7/365	56/18862	9.84298823487589e-05	0.000396293849394926	0.000152307291634395	AGO1/AGO2/DICER1/EGFR/IL6/BMP4/TERT	7
BP	GO:0060760	positive regulation of response to cytokine stimulus	7/365	56/18862	9.84298823487589e-05	0.000396293849394926	0.000152307291634395	EDN1/CASP4/IL1R1/CXCR4/HSPA1B/HSPA1A/TLR2	7
BP	GO:0070918	production of small RNA involved in gene silencing by RNA	7/365	56/18862	9.84298823487589e-05	0.000396293849394926	0.000152307291634395	AGO1/AGO2/DICER1/EGFR/IL6/BMP4/TERT	7
BP	GO:0006278	RNA-dependent DNA biosynthetic process	8/365	75/18862	9.92976247694171e-05	0.000399173400954784	0.000153413987334753	HSP90AA1/HSP90AB1/HNRNPA1/MAPK1/ATM/MAPK3/SRC/TERT	8
BP	GO:0043536	positive regulation of blood vessel endothelial cell migration	8/365	75/18862	9.92976247694171e-05	0.000399173400954784	0.000153413987334753	AKT3/SP1/HSPB1/ETS1/HMGB1/PRKCA/KDR/VEGFA	8
BP	GO:0045931	positive regulation of mitotic cell cycle	10/365	118/18862	9.95052537462994e-05	0.000399701072991659	0.000153616787097934	MECP2/BRD4/EIF4E/EGFR/CCND1/PRKCA/BRCA2/APP/TERT/CYP1A1	10
BP	GO:0043414	macromolecule methylation	17/365	305/18862	0.000100512684356881	0.00040343818245699	0.000155053067328059	DNMT3A/PARP1/CTNNB1/NSD1/MECP2/KMT2A/CREBBP/BRD4/KMT2D/KMT2C/DNMT1/BRCA1/FOS/MTHFR/TET1/MYC/CYP1A1	17
BP	GO:0016053	organic acid biosynthetic process	18/365	335/18862	0.000100656731272611	0.000403706767418271	0.000155156292366976	XBP1/CBS/PLP1/ABCD1/EDN1/MIF/PTGS1/CLN3/MTR/CYP2D6/CYP2E1/BRCA1/MTHFR/GSTM1/LPL/PLA2G4A/ADIPOQ/CYP1A1	18
BP	GO:0043255	regulation of carbohydrate biosynthetic process	9/365	96/18862	0.000101653447919873	0.000404891142803416	0.000155611482391917	EP300/MTOR/GSK3B/SNCA/PPARA/LEP/LEPR/IGF1/ADIPOQ	9
BP	GO:0110149	regulation of biomineralization	9/365	96/18862	0.000101653447919873	0.000404891142803416	0.000155611482391917	MEF2C/CEBPB/ATF4/P2RX7/ADRB2/NOTCH1/BGLAP/BMP4/BMP2	9
BP	GO:1901890	positive regulation of cell junction assembly	9/365	96/18862	0.000101653447919873	0.000404891142803416	0.000155611482391917	KDR/NLGN3/GHRL/IL1RAPL1/AGT/VEGFA/NTRK1/CAV1/NRXN1	9
BP	GO:0002068	glandular epithelial cell development	5/365	25/18862	0.000101957685558827	0.000404891142803416	0.000155611482391917	ARNTL/CLOCK/GSK3B/BMP4/CDH2	5
BP	GO:0002082	regulation of oxidative phosphorylation	5/365	25/18862	0.000101957685558827	0.000404891142803416	0.000155611482391917	ABCD1/NUPR1/PINK1/ATP7A/SNCA	5
BP	GO:0042737	drug catabolic process	5/365	25/18862	0.000101957685558827	0.000404891142803416	0.000155611482391917	CYP3A5/CYP2D6/CYP2U1/CYP2E1/NOS1	5
BP	GO:0048143	astrocyte activation	5/365	25/18862	0.000101957685558827	0.000404891142803416	0.000155611482391917	EGFR/AGER/IL6/APP/IFNG	5
BP	GO:0050995	negative regulation of lipid catabolic process	5/365	25/18862	0.000101957685558827	0.000404891142803416	0.000155611482391917	BSCL2/MFSD2A/SORL1/PIK3CG/CNR1	5
BP	GO:0060330	regulation of response to interferon-gamma	5/365	25/18862	0.000101957685558827	0.000404891142803416	0.000155611482391917	HSP90AB1/PPARG/STAT1/IFNG/SOCS1	5
BP	GO:0060334	regulation of interferon-gamma-mediated signaling pathway	5/365	25/18862	0.000101957685558827	0.000404891142803416	0.000155611482391917	HSP90AB1/PPARG/STAT1/IFNG/SOCS1	5
BP	GO:0060740	prostate gland epithelium morphogenesis	5/365	25/18862	0.000101957685558827	0.000404891142803416	0.000155611482391917	NOTCH1/AR/FGFR2/BMP4/SHH	5
BP	GO:0071450	cellular response to oxygen radical	5/365	25/18862	0.000101957685558827	0.000404891142803416	0.000155611482391917	ATP7A/PRDX1/SOD2/NQO1/MPO	5
BP	GO:0071451	cellular response to superoxide	5/365	25/18862	0.000101957685558827	0.000404891142803416	0.000155611482391917	ATP7A/PRDX1/SOD2/NQO1/MPO	5
BP	GO:0048736	appendage development	12/365	167/18862	0.000102731883008061	0.000407347481563779	0.000156555525062523	COL2A1/CTNNB1/GLI3/CREBBP/CHD7/BCL2L11/NOTCH1/FGFR2/DLX5/BMP4/BAX/SHH	12
BP	GO:0060173	limb development	12/365	167/18862	0.000102731883008061	0.000407347481563779	0.000156555525062523	COL2A1/CTNNB1/GLI3/CREBBP/CHD7/BCL2L11/NOTCH1/FGFR2/DLX5/BMP4/BAX/SHH	12
BP	GO:0051495	positive regulation of cytoskeleton organization	14/365	220/18862	0.000103432359154846	0.000409814510080594	0.000157503676118499	OCLN/EDN1/HRAS/MTOR/MECP2/DYNC1H1/P2RX7/ICAM1/SPAST/HSPA1B/HSPA1A/CSF3/NOX4/TRPV4	14
BP	GO:0045446	endothelial cell differentiation	10/365	119/18862	0.000106798488282419	0.00042251193323521	0.000162383666394322	TNFRSF1A/ICAM1/CXCR4/NRG1/KDR/NOTCH1/BMP4/VEGFA/XDH/PROC	10
BP	GO:0050868	negative regulation of T cell activation	10/365	119/18862	0.000106798488282419	0.00042251193323521	0.000162383666394322	GNRH1/CEBPB/GLI3/HMGB1/CTLA4/BMP4/HLA-DRB1/SOCS1/SHH/IL10	10
BP	GO:0007492	endoderm development	8/365	76/18862	0.000109135414710417	0.000430780362439157	0.00016556146504057	MMP9/MED12/GATA4/SOX2/NOTCH1/BMP4/MMP2/FN1	8
BP	GO:0051279	regulation of release of sequestered calcium ion into cytosol	8/365	76/18862	0.000109135414710417	0.000430780362439157	0.00016556146504057	HTT/SNCA/ANK2/CHD7/BAX/RYR2/CASQ2/NOS1	8
BP	GO:0072395	signal transduction involved in cell cycle checkpoint	8/365	76/18862	0.000109135414710417	0.000430780362439157	0.00016556146504057	EP300/PRKDC/GADD45A/ATM/BRCA1/CDKN1A/BAX/AURKA	8
BP	GO:0002027	regulation of heart rate	9/365	97/18862	0.000110170347218667	0.000433683204914221	0.000166677112119357	NPPA/EDN1/ANK2/KCNQ1/RYR2/CASQ2/CAV1/KCNH2/SCN5A	9
BP	GO:0043551	regulation of phosphatidylinositol 3-kinase activity	7/365	57/18862	0.000110367984131781	0.000433683204914221	0.000166677112119357	KLF4/PIK3R2/SRC/KIT/PDGFRB/SOCS1/P2RY12	7
BP	GO:0048008	platelet-derived growth factor receptor signaling pathway	7/365	57/18862	0.000110367984131781	0.000433683204914221	0.000166677112119357	PLAT/SNCA/SRC/TXNIP/PDGFRB/ADIPOQ/VEGFA	7
BP	GO:0055008	cardiac muscle tissue morphogenesis	7/365	57/18862	0.000110367984131781	0.000433683204914221	0.000166677112119357	LRP2/CHD7/NRG1/NOTCH1/FGFR2/RYR2/BMP2	7
BP	GO:0072431	signal transduction involved in mitotic G1 DNA damage checkpoint	7/365	57/18862	0.000110367984131781	0.000433683204914221	0.000166677112119357	EP300/PRKDC/GADD45A/ATM/CDKN1A/BAX/AURKA	7
BP	GO:1902400	intracellular signal transduction involved in G1 DNA damage checkpoint	7/365	57/18862	0.000110367984131781	0.000433683204914221	0.000166677112119357	EP300/PRKDC/GADD45A/ATM/CDKN1A/BAX/AURKA	7
BP	GO:0055090	acylglycerol homeostasis	6/365	40/18862	0.000110940307859138	0.000434626924651741	0.000167039811155698	XBP1/RORA/IL18/CETP/APOE/LPL	6
BP	GO:0070328	triglyceride homeostasis	6/365	40/18862	0.000110940307859138	0.000434626924651741	0.000167039811155698	XBP1/RORA/IL18/CETP/APOE/LPL	6
BP	GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	6/365	40/18862	0.000110940307859138	0.000434626924651741	0.000167039811155698	RPS27A/NFKBIA/IKBKG/XIAP/HSPA1B/HSPA1A	6
BP	GO:1903524	positive regulation of blood circulation	6/365	40/18862	0.000110940307859138	0.000434626924651741	0.000167039811155698	NPPA/EDN1/ATP1A1/KCNQ1/GHRL/RYR2	6
BP	GO:0007265	Ras protein signal transduction	18/365	338/18862	0.000112605430001724	0.000440820359483188	0.000169420128908628	HRAS/NF1/NGF/DNMT1/AGTR1/PIK3CG/APOE/CDKN1A/NOTCH1/KITLG/ABCA1/JUN/NGFR/IGF1/PDGFRB/NTRK1/RAB39B/CDKN2A	18
BP	GO:1901991	negative regulation of mitotic cell cycle phase transition	15/365	250/18862	0.00011411607030851	0.000446400233179925	0.000171564637211519	KLF4/BCL2/EP300/PRKDC/RAD21/GADD45A/ATM/BRCA1/CCND1/CDKN1A/CCL2/BAX/AURKA/GJC2/CDKN2A	15
BP	GO:0070252	actin-mediated cell contraction	10/365	120/18862	0.000114539003093462	0.00044772004644599	0.000172071879966673	NEDD4L/ATP1A1/GJA1/GATA4/ANK2/KCNQ1/RYR2/CAV1/KCNH2/SCN5A	10
BP	GO:0010649	regulation of cell communication by electrical coupling	4/365	14/18862	0.000118410928542478	0.000461133035707834	0.000177226883180353	GJA1/ANK3/CASQ2/CAV1	4
BP	GO:0014854	response to inactivity	4/365	14/18862	0.000118410928542478	0.000461133035707834	0.000177226883180353	DAG1/HDAC4/SCN5A/IL10	4
BP	GO:0038166	angiotensin-activated signaling pathway	4/365	14/18862	0.000118410928542478	0.000461133035707834	0.000177226883180353	AGTR1/SRC/CAMK2A/CAV1	4
BP	GO:0097284	hepatocyte apoptotic process	4/365	14/18862	0.000118410928542478	0.000461133035707834	0.000177226883180353	DNMT3A/PPARA/PIK3CG/KRT8	4
BP	GO:1905146	lysosomal protein catabolic process	4/365	14/18862	0.000118410928542478	0.000461133035707834	0.000177226883180353	LRP2/ATP13A2/CLN3/LAMP2	4
BP	GO:0019217	regulation of fatty acid metabolic process	9/365	98/18862	0.000119276708344942	0.000463814481038208	0.000178257440875252	ABCD1/MTOR/MFSD2A/PPARA/PPARG/BRCA1/ADIPOQ/CNR1/CAV1	9
BP	GO:0060996	dendritic spine development	9/365	98/18862	0.000119276708344942	0.000463814481038208	0.000178257440875252	MEF2C/MTOR/CDKL5/LRRK2/APOE/ACSL4/ADAM10/CAMK2A/RELN	9
BP	GO:0010827	regulation of glucose transmembrane transport	8/365	77/18862	0.000119765322537649	0.000464678797748	0.000178589623010765	OCLN/EDN1/SLC2A1/LEP/TERT/IGF1/ADIPOQ/C3	8
BP	GO:0048678	response to axon injury	8/365	77/18862	0.000119765322537649	0.000464678797748	0.000178589623010765	SPP1/KLF4/BCL2/DAG1/MTR/BAX/NTRK1/P2RY12	8
BP	GO:0055013	cardiac muscle cell development	8/365	77/18862	0.000119765322537649	0.000464678797748	0.000178589623010765	EDN1/MTOR/GATA4/PPARA/BMP4/IGF1/PDGFRB/VEGFA	8
BP	GO:0006913	nucleocytoplasmic transport	18/365	340/18862	0.000121248841523019	0.000470086249282579	0.000180667864444826	PIK3R2/SMN1/NFKBIA/TXN/GLI3/HSP90AB1/HNRNPA1/GSK3B/TARDBP/EIF4E/MAPK1/LEP/LRRK2/CDKN1A/BMP4/TXNIP/IFNG/SHH	18
BP	GO:0006479	protein methylation	12/365	170/18862	0.000121682750089284	0.000471070646425529	0.00018104619699519	CTNNB1/NSD1/MECP2/KMT2A/CREBBP/BRD4/KMT2D/KMT2C/DNMT1/BRCA1/MTHFR/TET1	12
BP	GO:0008213	protein alkylation	12/365	170/18862	0.000121682750089284	0.000471070646425529	0.00018104619699519	CTNNB1/NSD1/MECP2/KMT2A/CREBBP/BRD4/KMT2D/KMT2C/DNMT1/BRCA1/MTHFR/TET1	12
BP	GO:2000351	regulation of endothelial cell apoptotic process	7/365	58/18862	0.000123456559161066	0.000477584353768676	0.000183549604821097	ICAM1/KDR/FASLG/CCL2/TERT/SERPINE1/CD40LG	7
BP	GO:0003156	regulation of animal organ formation	5/365	26/18862	0.000124242403452843	0.000478150543876604	0.000183767208203083	AR/BMP4/GDNF/BMP2/SHH	5
BP	GO:0006706	steroid catabolic process	5/365	26/18862	0.000124242403452843	0.000478150543876604	0.000183767208203083	SPP1/CEL/HSD11B1/APOE/CYP19A1	5
BP	GO:0032104	regulation of response to extracellular stimulus	5/365	26/18862	0.000124242403452843	0.000478150543876604	0.000183767208203083	MTOR/PPARA/LEP/GHRL/NPY	5
BP	GO:0032107	regulation of response to nutrient levels	5/365	26/18862	0.000124242403452843	0.000478150543876604	0.000183767208203083	MTOR/PPARA/LEP/GHRL/NPY	5
BP	GO:0034114	regulation of heterotypic cell-cell adhesion	5/365	26/18862	0.000124242403452843	0.000478150543876604	0.000183767208203083	KLF4/AGER/IL1RN/ADIPOQ/IL10	5
BP	GO:0048520	positive regulation of behavior	5/365	26/18862	0.000124242403452843	0.000478150543876604	0.000183767208203083	MEF2C/MTOR/HDAC4/GJA1/GHRL	5
BP	GO:2000108	positive regulation of leukocyte apoptotic process	5/365	26/18862	0.000124242403452843	0.000478150543876604	0.000183767208203083	CCL5/MEF2C/BAX/CDKN2A/IL10	5
BP	GO:0072330	monocarboxylic acid biosynthetic process	14/365	224/18862	0.000125146522240588	0.000481276192069976	0.000184968486021705	XBP1/PLP1/ABCD1/EDN1/MIF/PTGS1/CYP2D6/CYP2E1/BRCA1/GSTM1/LPL/PLA2G4A/ADIPOQ/CYP1A1	14
BP	GO:0030850	prostate gland development	6/365	41/18862	0.000127860816893373	0.000489556339151364	0.000188150788190225	GLI3/NOTCH1/AR/FGFR2/BMP4/SHH	6
BP	GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	6/365	41/18862	0.000127860816893373	0.000489556339151364	0.000188150788190225	RPS27A/NFKBIA/IKBKG/XIAP/HSPA1B/HSPA1A	6
BP	GO:0051602	response to electrical stimulus	6/365	41/18862	0.000127860816893373	0.000489556339151364	0.000188150788190225	CD14/SRC/GHRL/SOD2/NTRK1/NQO1	6
BP	GO:0072091	regulation of stem cell proliferation	6/365	41/18862	0.000127860816893373	0.000489556339151364	0.000188150788190225	PTPRC/EIF2AK2/GJA1/KITLG/EPCAM/TERT	6
BP	GO:0090279	regulation of calcium ion import	6/365	41/18862	0.000127860816893373	0.000489556339151364	0.000188150788190225	PSEN2/CTNNB1/CXCL12/CCL2/PDGFRB/CALCR	6
BP	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	6/365	41/18862	0.000127860816893373	0.000489556339151364	0.000188150788190225	GSK3B/ICAM1/BRCA1/FAS/FASLG/SERPINE1	6
BP	GO:0019827	stem cell population maintenance	11/365	146/18862	0.000130635574169686	0.000499814762576124	0.000192093399690882	KLF4/CTNNB1/SMC1A/MED12/EIF4E/SOX2/NOTCH1/TET1/KIT/MYC/CDH2	11
BP	GO:0043537	negative regulation of blood vessel endothelial cell migration	8/365	78/18862	0.000131236003164971	0.000501379007712014	0.00019269458474703	KLF4/MEF2C/MECP2/GADD45A/PPARG/HMGB1/APOE/NOTCH1	8
BP	GO:0045913	positive regulation of carbohydrate metabolic process	8/365	78/18862	0.000131236003164971	0.000501379007712014	0.00019269458474703	P2RX7/SNCA/PPARA/SRC/HMGB1/APP/IFNG/IGF1	8
BP	GO:0051169	nuclear transport	18/365	343/18862	0.000135308346396929	0.000516560091204616	0.000198529118173083	PIK3R2/SMN1/NFKBIA/TXN/GLI3/HSP90AB1/HNRNPA1/GSK3B/TARDBP/EIF4E/MAPK1/LEP/LRRK2/CDKN1A/BMP4/TXNIP/IFNG/SHH	18
BP	GO:0019369	arachidonic acid metabolic process	7/365	59/18862	0.000137777415187434	0.000524074848176619	0.000201417258585668	PTGS1/CYP2D6/CYP2U1/CYP2E1/MAPK3/PLA2G4A/CYP1A1	7
BP	GO:0090303	positive regulation of wound healing	7/365	59/18862	0.000137777415187434	0.000524074848176619	0.000201417258585668	XBP1/OCLN/HRAS/MTOR/HMGB1/CXCR4/SERPINE1	7
BP	GO:1902041	regulation of extrinsic apoptotic signaling pathway via death domain receptors	7/365	59/18862	0.000137777415187434	0.000524074848176619	0.000201417258585668	GSK3B/ICAM1/BRCA1/ATF3/FAS/FASLG/SERPINE1	7
BP	GO:1902402	signal transduction involved in mitotic DNA damage checkpoint	7/365	59/18862	0.000137777415187434	0.000524074848176619	0.000201417258585668	EP300/PRKDC/GADD45A/ATM/CDKN1A/BAX/AURKA	7
BP	GO:1902403	signal transduction involved in mitotic DNA integrity checkpoint	7/365	59/18862	0.000137777415187434	0.000524074848176619	0.000201417258585668	EP300/PRKDC/GADD45A/ATM/CDKN1A/BAX/AURKA	7
BP	GO:0045833	negative regulation of lipid metabolic process	9/365	100/18862	0.000139386470756806	0.000529810303515703	0.000203621561454158	BSCL2/ATP1A1/MFSD2A/SORL1/PIK3CG/BRCA1/APOE/CNR1/BMP2	9
BP	GO:0006110	regulation of glycolytic process	8/365	79/18862	0.000143598095933266	0.00054502714584098	0.000209469838043182	NUPR1/EP300/P2RX7/HDAC4/PPARA/APP/IFNG/IGF1	8
BP	GO:0090398	cellular senescence	8/365	79/18862	0.000143598095933266	0.00054502714584098	0.000209469838043182	AKT3/HRAS/ARNTL/PRKDC/B2M/CDKN1A/TERT/CDKN2A	8
BP	GO:0046688	response to copper ion	6/365	42/18862	0.000146763821145999	0.000555833458667264	0.000213623019430272	MAP1LC3A/ATP7A/ICAM1/SNCA/APP/CYP1A1	6
BP	GO:0062208	positive regulation of pattern recognition receptor signaling pathway	6/365	42/18862	0.000146763821145999	0.000555833458667264	0.000213623019430272	RTN4/HMGB1/HSPA1B/HSPA1A/TLR2/CAV1	6
BP	GO:2001239	regulation of extrinsic apoptotic signaling pathway in absence of ligand	6/365	42/18862	0.000146763821145999	0.000555833458667264	0.000213623019430272	COL2A1/BCL2/HSPA1B/HSPA1A/TERT/GDNF	6
BP	GO:0002360	T cell lineage commitment	5/365	27/18862	0.000150075536435757	0.000564916094517779	0.000217113741452341	BCL2/PRKDC/MTOR/IL6/SHH	5
BP	GO:0002675	positive regulation of acute inflammatory response	5/365	27/18862	0.000150075536435757	0.000564916094517779	0.000217113741452341	PIK3CG/IL6/TNFSF11/CNR1/C3	5
BP	GO:0048265	response to pain	5/365	27/18862	0.000150075536435757	0.000564916094517779	0.000217113741452341	EDNRB/THBS4/NTRK1/RELN/DBH	5
BP	GO:0060512	prostate gland morphogenesis	5/365	27/18862	0.000150075536435757	0.000564916094517779	0.000217113741452341	NOTCH1/AR/FGFR2/BMP4/SHH	5
BP	GO:0099623	regulation of cardiac muscle cell membrane repolarization	5/365	27/18862	0.000150075536435757	0.000564916094517779	0.000217113741452341	NPPA/ANK2/KCNQ1/KCNH2/SCN5A	5
BP	GO:0140467	integrated stress response signaling	5/365	27/18862	0.000150075536435757	0.000564916094517779	0.000217113741452341	ATF4/DDIT3/ATF3/CCL2/PPP1R15A	5
BP	GO:1903649	regulation of cytoplasmic transport	5/365	27/18862	0.000150075536435757	0.000564916094517779	0.000217113741452341	SORL1/MAPK1/MAPK3/SRC/LRRK2	5
BP	GO:2000463	positive regulation of excitatory postsynaptic potential	5/365	27/18862	0.000150075536435757	0.000564916094517779	0.000217113741452341	ADRB2/NLGN3/GRIN1/NRXN1/RELN	5
BP	GO:0006721	terpenoid metabolic process	10/365	124/18862	0.000150421922100619	0.000564916094517779	0.000217113741452341	LRP2/CYP3A5/CYP2D6/CYP2E1/EGFR/ALDH3A2/APOE/LPL/TTR/CYP1A1	10
BP	GO:0042552	myelination	10/365	124/18862	0.000150421922100619	0.000564916094517779	0.000217113741452341	PLP1/ABCD1/DAG1/NF1/MTOR/DICER1/MPZ/CXCR4/TLR2/CLU	10
BP	GO:0097006	regulation of plasma lipoprotein particle levels	9/365	101/18862	0.000150457209735916	0.000564916094517779	0.000217113741452341	MFSD2A/AGTR1/CETP/APOE/ABCA1/LPL/AGT/ADIPOQ/MPO	9
BP	GO:1902106	negative regulation of leukocyte differentiation	9/365	101/18862	0.000150457209735916	0.000564916094517779	0.000217113741452341	GLI3/HMGB1/CTLA4/BMP4/MYC/SOCS1/ADIPOQ/FBN1/SHH	9
BP	GO:0032200	telomere organization	12/365	174/18862	0.000151559247941351	0.000568238612983548	0.000218390682262044	PARP1/PRKDC/HSP90AA1/HSP90AB1/HNRNPA1/MAPK1/ATM/MAPK3/SRC/BRCA2/TERT/MYC	12
BP	GO:0033209	tumor necrosis factor-mediated signaling pathway	12/365	174/18862	0.000151559247941351	0.000568238612983548	0.000218390682262044	NFKBIA/IKBKG/TNFRSF1A/CASP4/FAS/STAT1/HSPA1B/HSPA1A/KRT8/TNFSF11/ADIPOQ/CD40LG	12
BP	GO:0034113	heterotypic cell-cell adhesion	7/365	60/18862	0.000153415970631692	0.00057396654059062	0.000220592092003434	KLF4/PTPRC/AGER/VCAM1/IL1RN/ADIPOQ/IL10	7
BP	GO:0061098	positive regulation of protein tyrosine kinase activity	7/365	60/18862	0.000153415970631692	0.00057396654059062	0.000220592092003434	CCL5/SRC/NRG1/GHRL/AGT/NOX4/RELN	7
BP	GO:0090342	regulation of cell aging	7/365	60/18862	0.000153415970631692	0.00057396654059062	0.000220592092003434	MIF/AKT3/ARNTL/PRKDC/B2M/TERT/CDKN2A	7
BP	GO:0008203	cholesterol metabolic process	11/365	149/18862	0.000156447090886359	0.000584471144681801	0.000224629317918654	CEL/SP1/CYP2D6/NFE2L1/CETP/CFTR/LEP/APOE/ABCA1/APP/LEPR	11
BP	GO:0008643	carbohydrate transport	11/365	149/18862	0.000156447090886359	0.000584471144681801	0.000224629317918654	OCLN/SORT1/EDN1/MFSD2A/SLC2A1/LEP/TERT/IGF1/SLC2A4/ADIPOQ/C3	11
BP	GO:0006446	regulation of translational initiation	8/365	80/18862	0.000156904254713471	0.000584510227167478	0.00022464433845847	CCL5/EIF2AK2/AGO2/DNAJC3/MTOR/ATF4/HSPB1/PPP1R15A	8
BP	GO:0045445	myoblast differentiation	8/365	80/18862	0.000156904254713471	0.000584510227167478	0.00022464433845847	MEF2C/IL18/DDIT3/NRG1/NOTCH1/BMP4/IGF1/SHH	8
BP	GO:2000106	regulation of leukocyte apoptotic process	8/365	80/18862	0.000156904254713471	0.000584510227167478	0.00022464433845847	CCL5/MEF2C/KITLG/CXCL12/BMP4/BAX/CDKN2A/IL10	8
BP	GO:2000243	positive regulation of reproductive process	8/365	80/18862	0.000156904254713471	0.000584510227167478	0.00022464433845847	EDNRB/AGO2/HDAC4/SRC/AR/AURKA/VEGFA/SHH	8
BP	GO:0042976	activation of Janus kinase activity	4/365	15/18862	0.000159011823784971	0.000589842583763672	0.000226693718716163	CCL5/AGT/SOCS1/GHR	4
BP	GO:0043117	positive regulation of vascular permeability	4/365	15/18862	0.000159011823784971	0.000589842583763672	0.000226693718716163	OCLN/APOE/VEGFA/TRPV4	4
BP	GO:0043558	regulation of translational initiation in response to stress	4/365	15/18862	0.000159011823784971	0.000589842583763672	0.000226693718716163	EIF2AK2/DNAJC3/ATF4/PPP1R15A	4
BP	GO:0060572	morphogenesis of an epithelial bud	4/365	15/18862	0.000159011823784971	0.000589842583763672	0.000226693718716163	AR/FGFR2/BMP4/SHH	4
BP	GO:0071871	response to epinephrine	4/365	15/18862	0.000159011823784971	0.000589842583763672	0.000226693718716163	SNCA/KCNQ1/RYR2/ADIPOQ	4
BP	GO:0072075	metanephric mesenchyme development	4/365	15/18862	0.000159011823784971	0.000589842583763672	0.000226693718716163	STAT1/PDGFRB/MYC/SHH	4
BP	GO:0044242	cellular lipid catabolic process	14/365	230/18862	0.000165098433023185	0.00061155357285446	0.000235037885430258	CEL/ABCD1/MTOR/MFSD2A/SORL1/PPARA/PIK3CG/PLA2G6/LEP/ALDH3A2/LPL/PLA2G4A/ADIPOQ/CNR1	14
BP	GO:0098657	import into cell	14/365	230/18862	0.000165098433023185	0.00061155357285446	0.000235037885430258	LRP2/ATP1A1/SNCA/SLC9A6/SLC2A1/DRD4/IFNG/GDNF/KCNH2/TRPV4/CALCR/SLC6A1/NOS1/SLC6A4	14
BP	GO:0010830	regulation of myotube differentiation	6/365	43/18862	0.000167811974610291	0.000619850300007241	0.000238226559804082	XBP1/BCL2/MTOR/HDAC4/DMPK/NOTCH1	6
BP	GO:0032309	icosanoid secretion	6/365	43/18862	0.000167811974610291	0.000619850300007241	0.000238226559804082	EDN1/LEP/DRD4/TNFSF11/PLA2G4A/NOS2	6
BP	GO:0048599	oocyte development	6/365	43/18862	0.000167811974610291	0.000619850300007241	0.000238226559804082	BCL2/KMT2D/ATM/BRCA2/IGF1/AURKA	6
BP	GO:1900744	regulation of p38MAPK cascade	6/365	43/18862	0.000167811974610291	0.000619850300007241	0.000238226559804082	GADD45A/AGER/LEP/VEGFA/XDH/BMP2	6
BP	GO:0007033	vacuole organization	12/365	176/18862	0.000168714472511793	0.000622305531449417	0.000239170176899993	GABARAP/MAP1LC3A/NUPR1/PINK1/ATP13A2/CLN3/SCARB2/MTOR/WDR45/UBQLN2/LRRK2/ABCA1	12
BP	GO:0010921	regulation of phosphatase activity	12/365	176/18862	0.000168714472511793	0.000622305531449417	0.000239170176899993	PTPRC/EIF2AK2/MEF2C/HTT/MTOR/HSP90AB1/GSK3B/DMPK/PPP1R15A/IFNG/PDGFRB/BMP2	12
BP	GO:0072413	signal transduction involved in mitotic cell cycle checkpoint	7/365	61/18862	0.000170461291851297	0.000627863759007521	0.000241306365960093	EP300/PRKDC/GADD45A/ATM/CDKN1A/BAX/AURKA	7
BP	GO:1905330	regulation of morphogenesis of an epithelium	7/365	61/18862	0.000170461291851297	0.000627863759007521	0.000241306365960093	GJA1/AR/BMP4/AGT/GDNF/VEGFA/SHH	7
BP	GO:0022617	extracellular matrix disassembly	8/365	81/18862	0.000171209176536042	0.000629289908700592	0.000241854476907433	MMP9/ETS1/FURIN/CST3/IL6/MMP3/MMP2/ADAM10	8
BP	GO:0050672	negative regulation of lymphocyte proliferation	8/365	81/18862	0.000171209176536042	0.000629289908700592	0.000241854476907433	GNRH1/CEBPB/ATM/CTLA4/BMP4/HLA-DRB1/SHH/IL10	8
BP	GO:0060761	negative regulation of response to cytokine stimulus	8/365	81/18862	0.000171209176536042	0.000629289908700592	0.000241854476907433	KLF4/CCL5/PTPRC/PPARG/IL1RN/IL6/ADIPOQ/CAV1	8
BP	GO:0007272	ensheathment of neurons	10/365	126/18862	0.000171651498132005	0.00063003081432182	0.000242139228560022	PLP1/ABCD1/DAG1/NF1/MTOR/DICER1/MPZ/CXCR4/TLR2/CLU	10
BP	GO:0008366	axon ensheathment	10/365	126/18862	0.000171651498132005	0.00063003081432182	0.000242139228560022	PLP1/ABCD1/DAG1/NF1/MTOR/DICER1/MPZ/CXCR4/TLR2/CLU	10
BP	GO:0032526	response to retinoic acid	9/365	103/18862	0.000174807989787315	0.00064116679645887	0.000246419111484203	KLF4/SETX/GJA1/ATM/PPARG/LEP/FGFR2/PDGFRB/SLC6A4	9
BP	GO:0050770	regulation of axonogenesis	11/365	151/18862	0.000175961294900085	0.00064494497024303	0.000247871173930461	SPP1/L1CAM/GSK3B/RTN4/NGF/CDKL5/CXCL12/NGFR/CDH2/VEGFA/FN1	11
BP	GO:0001893	maternal placenta development	5/365	28/18862	0.000179821759494589	0.000656336882283598	0.000252249418185539	SPP1/GJA1/MAPK1/MAPK3/GHRL	5
BP	GO:0035883	enteroendocrine cell differentiation	5/365	28/18862	0.000179821759494589	0.000656336882283598	0.000252249418185539	ARNTL/CLOCK/GSK3B/BMP4/CDH2	5
BP	GO:0044030	regulation of DNA methylation	5/365	28/18862	0.000179821759494589	0.000656336882283598	0.000252249418185539	PARP1/MECP2/KMT2A/BRCA1/MYC	5
BP	GO:0071280	cellular response to copper ion	5/365	28/18862	0.000179821759494589	0.000656336882283598	0.000252249418185539	MAP1LC3A/ATP7A/SNCA/APP/CYP1A1	5
BP	GO:0071480	cellular response to gamma radiation	5/365	28/18862	0.000179821759494589	0.000656336882283598	0.000252249418185539	HRAS/ATM/CDKN1A/NOX4/EGR1	5
BP	GO:1903672	positive regulation of sprouting angiogenesis	5/365	28/18862	0.000179821759494589	0.000656336882283598	0.000252249418185539	KLF4/HMGB1/GHRL/VEGFA/IL10	5
BP	GO:0071333	cellular response to glucose stimulus	10/365	127/18862	0.000183177876200537	0.000667655295288031	0.000256599414616059	XBP1/IGF1R/ICAM1/GATA4/CFTR/UCP2/AGER/PLA2G6/GHRL/HLA-DRB1	10
BP	GO:1903052	positive regulation of proteolysis involved in cellular protein catabolic process	10/365	127/18862	0.000183177876200537	0.000667655295288031	0.000256599414616059	NUPR1/STUB1/GSK3B/UBQLN2/LRRK2/HSPA1B/HSPA1A/CLU/AURKA/CAV1	10
BP	GO:0032410	negative regulation of transporter activity	8/365	82/18862	0.000186569628698293	0.000679071930880992	0.000260987160853845	MMP9/NEDD4L/SNCA/ANK3/DRD4/CASQ2/CRHR1/CAV1	8
BP	GO:0032945	negative regulation of mononuclear cell proliferation	8/365	82/18862	0.000186569628698293	0.000679071930880992	0.000260987160853845	GNRH1/CEBPB/ATM/CTLA4/BMP4/HLA-DRB1/SHH/IL10	8
BP	GO:0031396	regulation of protein ubiquitination	13/365	205/18862	0.000187979119827841	0.000683726694356443	0.000262776122300578	PINK1/STUB1/RPL5/MTOR/HSP90AA1/XIAP/HSP90AB1/HUWE1/BRCA1/LRRK2/HSPA1B/HSPA1A/CAV1	13
BP	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	9/365	104/18862	0.00018816284382344	0.000683919669841588	0.000262850288411253	STUB1/GSK3B/UBQLN2/LRRK2/HSPA1B/HSPA1A/CLU/AURKA/CAV1	9
BP	GO:0032835	glomerulus development	7/365	62/18862	0.000189006125940822	0.000685556523336286	0.00026347937897867	BCL2/MEF2C/NOTCH1/BMP4/PDGFRB/ADIPOQ/EGR1	7
BP	GO:0051851	modulation by host of symbiont process	7/365	62/18862	0.000189006125940822	0.000685556523336286	0.00026347937897867	CCL5/EP300/TARDBP/SP1/APOE/PPIB/JUN	7
BP	GO:0070527	platelet aggregation	7/365	62/18862	0.000189006125940822	0.000685556523336286	0.00026347937897867	STXBP1/HSPB1/PIK3CG/PRKCA/HBB/FN1/P2RY12	7
BP	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	6/365	44/18862	0.000191175265429039	0.000690553029161899	0.000265399681983869	MIF/BCL2/NUPR1/EP300/CDKN1A/BRCA2	6
BP	GO:0048168	regulation of neuronal synaptic plasticity	6/365	44/18862	0.000191175265429039	0.000690553029161899	0.000265399681983869	HRAS/CLN3/APOE/KIT/APP/CAMK2A	6
BP	GO:0055010	ventricular cardiac muscle tissue morphogenesis	6/365	44/18862	0.000191175265429039	0.000690553029161899	0.000265399681983869	LRP2/CHD7/NRG1/NOTCH1/FGFR2/RYR2	6
BP	GO:0060324	face development	6/365	44/18862	0.000191175265429039	0.000690553029161899	0.000265399681983869	EP300/MAPK1/MAPK3/CHD7/DLX5/MMP2	6
BP	GO:0090199	regulation of release of cytochrome c from mitochondria	6/365	44/18862	0.000191175265429039	0.000690553029161899	0.000265399681983869	MMP9/PINK1/BCL2L11/BAX/IGF1/CLU	6
BP	GO:1903573	negative regulation of response to endoplasmic reticulum stress	6/365	44/18862	0.000191175265429039	0.000690553029161899	0.000265399681983869	XBP1/DNAJC3/LRRK2/PPP1R15A/HSPA1A/CLU	6
BP	GO:0032479	regulation of type I interferon production	10/365	128/18862	0.000195348319117697	0.000705140070525536	0.000271005907683426	CTNNB1/EP300/PRKDC/HSP90AA1/CREBBP/CD14/HMGB1/STAT1/TLR2/IL10	10
BP	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	13/365	206/18862	0.000197204826569137	0.00071062907458041	0.000273115492131039	TRAPPC9/VAPB/DYNC1H1/SORL1/ANK2/SPAST/SERPINA1/MIA2/LRRK2/BGLAP/ANK3/GRIA1/PROC	13
BP	GO:0007034	vacuolar transport	11/365	153/18862	0.000197502613127454	0.00071062907458041	0.000273115492131039	SORT1/PINK1/ATP13A2/CLN3/SCARB2/SORL1/LAMP2/ADRB2/LRRK2/HSPA1A/CLU	11
BP	GO:0016573	histone acetylation	11/365	153/18862	0.000197502613127454	0.00071062907458041	0.000273115492131039	HCFC1/EP300/CLOCK/MECP2/KMT2A/CREBBP/SNCA/MAPK3/BRCA1/BRCA2/NOS1	11
BP	GO:0051250	negative regulation of lymphocyte activation	11/365	153/18862	0.000197502613127454	0.00071062907458041	0.000273115492131039	GNRH1/CEBPB/GLI3/ATM/HMGB1/CTLA4/BMP4/HLA-DRB1/SOCS1/SHH/IL10	11
BP	GO:0030177	positive regulation of Wnt signaling pathway	12/365	179/18862	0.000197547822604986	0.00071062907458041	0.000273115492131039	ARNTL/XIAP/SRC/EGFR/LRRK2/FGFR2/DLX5/TLR2/TERT/CAV1/BMP2/SHH	12
BP	GO:0019395	fatty acid oxidation	9/365	105/18862	0.000202356025006786	0.000726926173565901	0.000279378942880445	ABCD1/MTOR/MFSD2A/PPARA/PPARG/LEP/ALDH3A2/ADIPOQ/CNR1	9
BP	GO:1903707	negative regulation of hemopoiesis	9/365	105/18862	0.000202356025006786	0.000726926173565901	0.000279378942880445	GLI3/HMGB1/CTLA4/BMP4/MYC/SOCS1/ADIPOQ/FBN1/SHH	9
BP	GO:1901019	regulation of calcium ion transmembrane transporter activity	8/365	83/18862	0.000203044474303676	0.000728899025038025	0.000280137167276244	NPPA/HTT/ANK2/DRD4/RYR2/CASQ2/CRHR1/NOS1	8
BP	GO:0015849	organic acid transport	17/365	324/18862	0.000207036135607805	0.00074215256031763	0.000285230887671096	LRP2/ABCD1/EDN1/STXBP1/CLN3/MFSD2A/GJA1/PPARA/PPARG/SLC2A1/LEP/APOE/ACSL4/DRD4/TNFSF11/PLA2G4A/SLC6A1	17
BP	GO:0032606	type I interferon production	10/365	129/18862	0.000208191149709239	0.00074215256031763	0.000285230887671096	CTNNB1/EP300/PRKDC/HSP90AA1/CREBBP/CD14/HMGB1/STAT1/TLR2/IL10	10
BP	GO:0046328	regulation of JNK cascade	10/365	129/18862	0.000208191149709239	0.00074215256031763	0.000285230887671096	NPPA/IGF1R/HRAS/PINK1/GADD45A/EGFR/HMGB1/AGER/APP/TNFSF11	10
BP	GO:0071331	cellular response to hexose stimulus	10/365	129/18862	0.000208191149709239	0.00074215256031763	0.000285230887671096	XBP1/IGF1R/ICAM1/GATA4/CFTR/UCP2/AGER/PLA2G6/GHRL/HLA-DRB1	10
BP	GO:0006349	regulation of gene expression by genetic imprinting	4/365	16/18862	0.000208790843619211	0.00074215256031763	0.000285230887671096	DNMT3A/MECP2/BRCA1/KCNQ1	4
BP	GO:0014874	response to stimulus involved in regulation of muscle adaptation	4/365	16/18862	0.000208790843619211	0.00074215256031763	0.000285230887671096	DAG1/HDAC4/AGT/SCN5A	4
BP	GO:0031649	heat generation	4/365	16/18862	0.000208790843619211	0.00074215256031763	0.000285230887671096	EDNRB/ADRB2/TNFSF11/CNR1	4
BP	GO:0044764	multi-organism cellular process	4/365	16/18862	0.000208790843619211	0.00074215256031763	0.000285230887671096	CCR5/CD4/CXCR4/CAV1	4
BP	GO:0051580	regulation of neurotransmitter uptake	4/365	16/18862	0.000208790843619211	0.00074215256031763	0.000285230887671096	SNCA/DRD4/GDNF/NOS1	4
BP	GO:0051709	regulation of killing of cells of other organism	4/365	16/18862	0.000208790843619211	0.00074215256031763	0.000285230887671096	P2RX7/BCL2L11/IFNG/NOS2	4
BP	GO:0060977	coronary vasculature morphogenesis	4/365	16/18862	0.000208790843619211	0.00074215256031763	0.000285230887671096	LRP2/NOTCH1/PDGFRB/VEGFA	4
BP	GO:0070242	thymocyte apoptotic process	4/365	16/18862	0.000208790843619211	0.00074215256031763	0.000285230887671096	GLI3/BCL2L11/BMP4/BAX	4
BP	GO:0072109	glomerular mesangium development	4/365	16/18862	0.000208790843619211	0.00074215256031763	0.000285230887671096	NOTCH1/BMP4/PDGFRB/EGR1	4
BP	GO:0090083	regulation of inclusion body assembly	4/365	16/18862	0.000208790843619211	0.00074215256031763	0.000285230887671096	SORL1/HSPA1B/HSPA1A/CLU	4
BP	GO:0045670	regulation of osteoclast differentiation	7/365	63/18862	0.000209146929015763	0.00074215256031763	0.000285230887671096	CEBPB/MTOR/FOS/BGLAP/IFNG/TNFSF11/FBN1	7
BP	GO:0061077	chaperone-mediated protein folding	7/365	63/18862	0.000209146929015763	0.00074215256031763	0.000285230887671096	DNAJC5/HSPB1/FKBP5/PPIB/HSPA1B/HSPA1A/CLU	7
BP	GO:0071677	positive regulation of mononuclear cell migration	7/365	63/18862	0.000209146929015763	0.00074215256031763	0.000285230887671096	CCL5/HMGB1/AGER/CXCL12/APP/SERPINE1/ADAM10	7
BP	GO:0019048	modulation by virus of host process	5/365	29/18862	0.000213862342779448	0.000754282683360937	0.000289892847958239	CD4/EIF2AK2/DAG1/VAPB/BCL2L11	5
BP	GO:0036336	dendritic cell migration	5/365	29/18862	0.000213862342779448	0.000754282683360937	0.000289892847958239	CCR5/CCL5/PIK3CG/HMGB1/CXCR4	5
BP	GO:0040018	positive regulation of multicellular organism growth	5/365	29/18862	0.000213862342779448	0.000754282683360937	0.000289892847958239	BCL2/CHD7/PPIB/GHRL/GHR	5
BP	GO:0042133	neurotransmitter metabolic process	5/365	29/18862	0.000213862342779448	0.000754282683360937	0.000289892847958239	MAOA/CLN3/NOS1/SLC6A4/DBH	5
BP	GO:0060914	heart formation	5/365	29/18862	0.000213862342779448	0.000754282683360937	0.000289892847958239	LRP2/MEF2C/NOTCH1/BMP4/BMP2	5
BP	GO:1900101	regulation of endoplasmic reticulum unfolded protein response	5/365	29/18862	0.000213862342779448	0.000754282683360937	0.000289892847958239	XBP1/ATF6/BCL2L11/PPP1R15A/BAX	5
BP	GO:1901380	negative regulation of potassium ion transmembrane transport	5/365	29/18862	0.000213862342779448	0.000754282683360937	0.000289892847958239	NEDD4L/ANK3/CASQ2/CAV1/KCNH2	5
BP	GO:1902430	negative regulation of amyloid-beta formation	5/365	29/18862	0.000213862342779448	0.000754282683360937	0.000289892847958239	RTN4/SORL1/APOE/IGF1/CLU	5
BP	GO:1903579	negative regulation of ATP metabolic process	5/365	29/18862	0.000213862342779448	0.000754282683360937	0.000289892847958239	NUPR1/PARP1/HDAC4/SNCA/PPARA	5
BP	GO:0031348	negative regulation of defense response	14/365	236/18862	0.00021562606749588	0.000759991136211067	0.000292086772982191	KLF4/PTPRC/RORA/TNFRSF1A/PPARA/PPARG/APOE/GHRL/HLA-DRB1/NLRP3/IGF1/ADIPOQ/IL10/PROC	14
BP	GO:0002221	pattern recognition receptor signaling pathway	13/365	208/18862	0.000216826849222298	0.000761216786217174	0.000292557826048513	RPS27A/NFKBIA/IKBKG/RPS6KA3/XIAP/RTN4/CD14/HMGB1/HSPA1B/HSPA1A/TLR2/CTSB/CAV1	13
BP	GO:0031018	endocrine pancreas development	6/365	45/18862	0.000217030994599725	0.000761216786217174	0.000292557826048513	ARNTL/CLOCK/GSK3B/IL6/BMP4/CDH2	6
BP	GO:0035307	positive regulation of protein dephosphorylation	6/365	45/18862	0.000217030994599725	0.000761216786217174	0.000292557826048513	PTPRC/PINK1/MTOR/HSP90AB1/PPP1R15A/PDGFRB	6
BP	GO:0045601	regulation of endothelial cell differentiation	6/365	45/18862	0.000217030994599725	0.000761216786217174	0.000292557826048513	TNFRSF1A/NOTCH1/BMP4/VEGFA/XDH/PROC	6
BP	GO:1900271	regulation of long-term synaptic potentiation	6/365	45/18862	0.000217030994599725	0.000761216786217174	0.000292557826048513	GSK3B/AGER/APOE/APP/MME/RELN	6
BP	GO:0009062	fatty acid catabolic process	9/365	106/18862	0.000217428180243538	0.000761216786217174	0.000292557826048513	CEL/ABCD1/MTOR/MFSD2A/PPARA/LEP/ALDH3A2/ADIPOQ/CNR1	9
BP	GO:0018958	phenol-containing compound metabolic process	9/365	106/18862	0.000217428180243538	0.000761216786217174	0.000292557826048513	MAOA/BCL2/ZEB2/ATP7A/SNCA/CYP2E1/DRD4/GRIN2A/DBH	9
BP	GO:0030330	DNA damage response, signal transduction by p53 class mediator	9/365	106/18862	0.000217428180243538	0.000761216786217174	0.000292557826048513	MIF/EP300/GADD45A/ATM/BRCA1/CDKN1A/BRCA2/BAX/AURKA	9
BP	GO:0048259	regulation of receptor-mediated endocytosis	9/365	106/18862	0.000217428180243538	0.000761216786217174	0.000292557826048513	UBQLN2/TF/B2M/DRD4/SERPINE1/CLU/ADIPOQ/VEGFA/C3	9
BP	GO:0120034	positive regulation of plasma membrane bounded cell projection assembly	9/365	106/18862	0.000217428180243538	0.000761216786217174	0.000292557826048513	OCLN/HRAS/HTT/ATP7A/MTOR/P2RX7/HDAC4/KIT/P2RY12	9
BP	GO:0010822	positive regulation of mitochondrion organization	8/365	84/18862	0.000220694696189698	0.000772136390278661	0.000296754548563546	MMP9/BCL2/PINK1/HTT/GSK3B/BCL2L11/KDR/BAX	8
BP	GO:0032507	maintenance of protein location in cell	7/365	64/18862	0.00023098388993923	0.000805979786627954	0.000309761553455347	CD4/PINK1/TXN/SORL1/GJA1/ANK3/CAV1	7
BP	GO:0033344	cholesterol efflux	7/365	64/18862	0.00023098388993923	0.000805979786627954	0.000309761553455347	NFKBIA/CETP/APOE/ABCA1/ADIPOQ/CAV1/SHH	7
BP	GO:0035914	skeletal muscle cell differentiation	7/365	64/18862	0.00023098388993923	0.000805979786627954	0.000309761553455347	MEF2C/ARNTL/NUPR1/ATF3/FOS/NOTCH1/EGR1	7
BP	GO:0071300	cellular response to retinoic acid	7/365	64/18862	0.00023098388993923	0.000805979786627954	0.000309761553455347	KLF4/SETX/ATM/PPARG/LEP/FGFR2/SLC6A4	7
BP	GO:0034968	histone lysine methylation	9/365	107/18862	0.000233421283715058	0.000813400132466452	0.000312613408914062	CTNNB1/NSD1/MECP2/KMT2A/BRD4/KMT2D/KMT2C/DNMT1/BRCA1	9
BP	GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	9/365	107/18862	0.000233421283715058	0.000813400132466452	0.000312613408914062	PARP1/EP300/HSP90AB1/CREBBP/GATA4/NOTCH1/BMP4/GDF15/BMP2	9
BP	GO:0007292	female gamete generation	10/365	131/18862	0.000236011628065333	0.000821333019477364	0.000315662248903172	BCL2/RPS6/USP9X/KMT2D/ATM/SRC/LEP/BRCA2/IGF1/AURKA	10
BP	GO:0042770	signal transduction in response to DNA damage	10/365	131/18862	0.000236011628065333	0.000821333019477364	0.000315662248903172	MIF/EP300/PRKDC/GADD45A/ATM/BRCA1/CDKN1A/BRCA2/BAX/AURKA	10
BP	GO:0001654	eye development	18/365	359/18862	0.000237209144738266	0.000824404159070441	0.000316842577475939	KLF4/BCL2/ATF6/GLI3/NF1/ATF4/MFSD2A/CHD7/SOX2/HMGB1/FASLG/BMP4/BAX/PDGFRB/CYP1A1/VEGFA/FBN1/SHH	18
BP	GO:0032259	methylation	18/365	359/18862	0.000237209144738266	0.000824404159070441	0.000316842577475939	DNMT3A/PARP1/CTNNB1/NSD1/MTR/MECP2/KMT2A/CREBBP/BRD4/KMT2D/KMT2C/DNMT1/BRCA1/FOS/MTHFR/TET1/MYC/CYP1A1	18
BP	GO:0046889	positive regulation of lipid biosynthetic process	8/365	85/18862	0.000239583419203808	0.000831551469570777	0.000319589497486024	ABCD1/MTOR/MFSD2A/TNFRSF1A/PPARA/APOE/IFNG/HTR2C	8
BP	GO:0048477	oogenesis	8/365	85/18862	0.000239583419203808	0.000831551469570777	0.000319589497486024	BCL2/RPS6/KMT2D/ATM/SRC/BRCA2/IGF1/AURKA	8
BP	GO:1901988	negative regulation of cell cycle phase transition	15/365	268/18862	0.000243833738852074	0.000845742736349739	0.000325043615462533	KLF4/BCL2/EP300/PRKDC/RAD21/GADD45A/ATM/BRCA1/CCND1/CDKN1A/CCL2/BAX/AURKA/GJC2/CDKN2A	15
BP	GO:0002449	lymphocyte mediated immunity	18/365	360/18862	0.000245366388788338	0.000850053318737885	0.000326700298072944	PTPRC/ICAM1/IL18/IL1R1/HMGB1/AGER/LEP/B2M/IL6/C4A/HLA-DRB1/NLRP3/CLU/HLA-DQB1/C3/CD40LG/IL10/MBL2	18
BP	GO:0050873	brown fat cell differentiation	6/365	46/18862	0.000245563740529553	0.000850053318737885	0.000326700298072944	CEBPB/MTOR/ADRB2/LEP/SLC2A4/ADIPOQ	6
BP	GO:2001258	negative regulation of cation channel activity	6/365	46/18862	0.000245563740529553	0.000850053318737885	0.000326700298072944	MMP9/ANK3/DRD4/CASQ2/CRHR1/CAV1	6
BP	GO:0006417	regulation of translation	20/365	425/18862	0.000250722497219301	0.000867337442462538	0.000333343091234622	CCL5/EIF2AK2/AGO1/PINK1/PURA/RPS6KA3/AGO2/DNAJC3/PRKDC/RPL5/MTOR/ATF4/TARDBP/HSPB1/EIF4E/MAPK1/MAPK3/IL6/PPP1R15A/APP	20
BP	GO:0046685	response to arsenic-containing substance	5/365	30/18862	0.000252594608813781	0.000872084553120929	0.000335167544398788	ATF4/HNRNPA1/ATF3/CDKN1A/CYP1A1	5
BP	GO:0060045	positive regulation of cardiac muscle cell proliferation	5/365	30/18862	0.000252594608813781	0.000872084553120929	0.000335167544398788	MEF2C/MAPK1/NOTCH1/FGFR2/ERBB4	5
BP	GO:1902235	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	5/365	30/18862	0.000252594608813781	0.000872084553120929	0.000335167544398788	XBP1/BCL2L11/DDIT3/LRRK2/HSPA1A	5
BP	GO:0071479	cellular response to ionizing radiation	7/365	65/18862	0.000254620949460822	0.000878501021409323	0.00033763358041816	HRAS/CLOCK/GADD45A/ATM/CDKN1A/NOX4/EGR1	7
BP	GO:0002040	sprouting angiogenesis	12/365	184/18862	0.000254945680110402	0.00087904195632269	0.000337841477491837	KLF4/AKT3/AGTR1/HMGB1/KDR/NOTCH1/BMP4/NGFR/GHRL/VEGFA/NR4A1/IL10	12
BP	GO:0032755	positive regulation of interleukin-6 production	8/365	86/18862	0.000259775930789309	0.000893929797338095	0.000343563309276009	XBP1/HMGB1/AGER/IL6/TLR2/APP/IFNG/LPL	8
BP	GO:0048013	ephrin receptor signaling pathway	8/365	86/18862	0.000259775930789309	0.000893929797338095	0.000343563309276009	MMP9/HRAS/PSEN2/SRC/GRIN1/MMP2/NTRK1/GRIN2B	8
BP	GO:1901379	regulation of potassium ion transmembrane transport	8/365	86/18862	0.000259775930789309	0.000893929797338095	0.000343563309276009	NPPA/NEDD4L/ANK2/ANK3/KCNQ1/CASQ2/CAV1/KCNH2	8
BP	GO:0071805	potassium ion transmembrane transport	13/365	212/18862	0.000261132791572838	0.000896955948976159	0.000344726347664751	NPPA/NEDD4L/ATP1A1/ANK2/SLC9A6/ANK3/KCNQ1/CASQ2/KCNA2/CAV1/KCNH2/P2RY12/KCNQ2	13
BP	GO:0018393	internal peptidyl-lysine acetylation	11/365	158/18862	0.000261340814327215	0.000896955948976159	0.000344726347664751	HCFC1/EP300/CLOCK/MECP2/KMT2A/CREBBP/SNCA/MAPK3/BRCA1/BRCA2/NOS1	11
BP	GO:0032675	regulation of interleukin-6 production	11/365	158/18862	0.000261340814327215	0.000896955948976159	0.000344726347664751	XBP1/CEBPB/HMGB1/AGER/IL6/TLR2/GHRL/APP/IFNG/LPL/IL10	11
BP	GO:1902652	secondary alcohol metabolic process	11/365	158/18862	0.000261340814327215	0.000896955948976159	0.000344726347664751	CEL/SP1/CYP2D6/NFE2L1/CETP/CFTR/LEP/APOE/ABCA1/APP/LEPR	11
BP	GO:0051216	cartilage development	12/365	185/18862	0.000267982544044638	0.000918627656316219	0.000353055417255655	COL2A1/EDN1/MEF2C/ATP7A/GLI3/MAPK3/LEP/BMP4/GHRL/SATB2/TRPV4/BMP2	12
BP	GO:0002076	osteoblast development	4/365	17/18862	0.000268883754198786	0.000918627656316219	0.000353055417255655	HDAC4/BGLAP/SATB2/SHH	4
BP	GO:0007158	neuron cell-cell adhesion	4/365	17/18862	0.000268883754198786	0.000918627656316219	0.000353055417255655	CEL/NLGN3/ASTN2/NRXN1	4
BP	GO:0033599	regulation of mammary gland epithelial cell proliferation	4/365	17/18862	0.000268883754198786	0.000918627656316219	0.000353055417255655	RTN4/CCND1/BRCA2/BAX	4
BP	GO:0060438	trachea development	4/365	17/18862	0.000268883754198786	0.000918627656316219	0.000353055417255655	MAPK1/MAPK3/BMP4/SHH	4
BP	GO:0150078	positive regulation of neuroinflammatory response	4/365	17/18862	0.000268883754198786	0.000918627656316219	0.000353055417255655	NUPR1/IL18/LRRK2/IL6	4
BP	GO:2000811	negative regulation of anoikis	4/365	17/18862	0.000268883754198786	0.000918627656316219	0.000353055417255655	BCL2/SRC/NOTCH1/CAV1	4
BP	GO:0009994	oocyte differentiation	6/365	47/18862	0.000276965309789284	0.000944388554682158	0.000362956082295438	BCL2/KMT2D/ATM/BRCA2/IGF1/AURKA	6
BP	GO:0031279	regulation of cyclase activity	6/365	47/18862	0.000276965309789284	0.000944388554682158	0.000362956082295438	EDNRB/NF1/MAPK3/CRHR1/NOS2/NOS1	6
BP	GO:0045581	negative regulation of T cell differentiation	6/365	47/18862	0.000276965309789284	0.000944388554682158	0.000362956082295438	GLI3/HMGB1/CTLA4/BMP4/SOCS1/SHH	6
BP	GO:0043543	protein acylation	14/365	242/18862	0.000278946519358162	0.000950524793177486	0.000365314417827198	ARNTL/NUPR1/HCFC1/EP300/CLOCK/MECP2/KMT2A/GSK3B/CREBBP/SNCA/MAPK3/BRCA1/BRCA2/NOS1	14
BP	GO:0042130	negative regulation of T cell proliferation	7/365	66/18862	0.000280165814746494	0.000952818631827907	0.000366196006963202	GNRH1/CEBPB/CTLA4/BMP4/HLA-DRB1/SHH/IL10	7
BP	GO:0050805	negative regulation of synaptic transmission	7/365	66/18862	0.000280165814746494	0.000952818631827907	0.000366196006963202	STXBP1/BCHE/AGER/LRRK2/ADIPOQ/GRIA1/SLC6A4	7
BP	GO:0072678	T cell migration	7/365	66/18862	0.000280165814746494	0.000952818631827907	0.000366196006963202	CCL5/ICAM1/PIK3CG/CXCL12/CCL2/APP/ADAM10	7
BP	GO:0006112	energy reserve metabolic process	8/365	87/18862	0.000281339699845974	0.000954949409204816	0.000367014926893068	MTOR/GSK3B/HMGB1/LEP/LEPR/IGF1/MYC/POMC	8
BP	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	8/365	87/18862	0.000281339699845974	0.000954949409204816	0.000367014926893068	SNCA/NGF/PPARG/FAS/FASLG/NGFR/BAX/XDH	8
BP	GO:0150104	transport across blood-brain barrier	8/365	87/18862	0.000281339699845974	0.000954949409204816	0.000367014926893068	LRP2/MFSD2A/AGER/SLC2A1/APOE/LEPR/SLC2A4/SLC6A1	8
BP	GO:0120032	regulation of plasma membrane bounded cell projection assembly	12/365	186/18862	0.000281581600516834	0.000955151067469285	0.000367092430049234	OCLN/HRAS/HTT/ATP7A/MTOR/P2RX7/HDAC4/ICAM1/CDKL5/KIT/CAV1/P2RY12	12
BP	GO:0090101	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	10/365	134/18862	0.000283543991997629	0.000961184750074864	0.000369411350359605	LRP2/RPS27A/STUB1/SORL1/PPARA/PPARG/NOTCH1/HSPA1A/FBN1/CAV1	10
BP	GO:0034440	lipid oxidation	9/365	110/18862	0.00028736627059346	0.000973511365881017	0.000374148828549891	ABCD1/MTOR/MFSD2A/PPARA/PPARG/LEP/ALDH3A2/ADIPOQ/CNR1	9
BP	GO:0006475	internal protein amino acid acetylation	11/365	160/18862	0.000291352125602059	0.00098637582496842	0.000379093015609406	HCFC1/EP300/CLOCK/MECP2/KMT2A/CREBBP/SNCA/MAPK3/BRCA1/BRCA2/NOS1	11
BP	GO:1902115	regulation of organelle assembly	12/365	187/18862	0.000295762258713341	0.00100033636340247	0.000384458457949463	NUPR1/PINK1/HTT/DYNC1H1/SRC/BRCA1/ALMS1/UBQLN2/CDKL5/LRRK2/HSPA1B/HSPA1A	12
BP	GO:0003180	aortic valve morphogenesis	5/365	31/18862	0.000296431352624613	0.00100033636340247	0.000384458457949463	NPPA/GATA4/NOTCH1/ELN/BMP4	5
BP	GO:0045907	positive regulation of vasoconstriction	5/365	31/18862	0.000296431352624613	0.00100033636340247	0.000384458457949463	GJA1/ICAM1/EGFR/CAV1/DBH	5
BP	GO:0048147	negative regulation of fibroblast proliferation	5/365	31/18862	0.000296431352624613	0.00100033636340247	0.000384458457949463	NUPR1/NF1/PPARG/BAX/MYC	5
BP	GO:0098810	neurotransmitter reuptake	5/365	31/18862	0.000296431352624613	0.00100033636340247	0.000384458457949463	SNCA/DRD4/GDNF/NOS1/SLC6A4	5
BP	GO:0070664	negative regulation of leukocyte proliferation	8/365	88/18862	0.000304344393832825	0.00102637793641818	0.00039446699444827	GNRH1/CEBPB/ATM/CTLA4/BMP4/HLA-DRB1/SHH/IL10	8
BP	GO:0002244	hematopoietic progenitor cell differentiation	11/365	161/18862	0.000307415110878273	0.00103313576603609	0.000397064225588757	PTPRC/BCL2/EIF2AK2/PRKDC/KMT2A/KDR/NOTCH1/KITLG/BMP4/KIT/SHH	11
BP	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	7/365	67/18862	0.000307729969287403	0.00103313576603609	0.000397064225588757	CCL2/DRD4/AGT/CNR1/CHRM3/HTR2C/NPY	7
BP	GO:0045669	positive regulation of osteoblast differentiation	7/365	67/18862	0.000307729969287403	0.00103313576603609	0.000397064225588757	MEF2C/CEBPB/GLI3/IL6/BMP4/IGF1/BMP2	7
BP	GO:0050848	regulation of calcium-mediated signaling	7/365	67/18862	0.000307729969287403	0.00103313576603609	0.000397064225588757	CD4/HTT/MTOR/GSK3B/LRRK2/ITPR1/IGF1	7
BP	GO:0060415	muscle tissue morphogenesis	7/365	67/18862	0.000307729969287403	0.00103313576603609	0.000397064225588757	LRP2/CHD7/NRG1/NOTCH1/FGFR2/RYR2/BMP2	7
BP	GO:1905953	negative regulation of lipid localization	7/365	67/18862	0.000307729969287403	0.00103313576603609	0.000397064225588757	NFKBIA/PPARA/PPARG/LEP/IL6/ABCA1/SHH	7
BP	GO:2000514	regulation of CD4-positive, alpha-beta T cell activation	7/365	67/18862	0.000307729969287403	0.00103313576603609	0.000397064225588757	IL18/HMGB1/AGER/HLA-DRB1/NLRP3/IFNG/SOCS1	7
BP	GO:0006692	prostanoid metabolic process	6/365	48/18862	0.000311434674437685	0.00104289768778429	0.000400816017005365	EDN1/MIF/PTGS1/TNFRSF1A/GSTM1/PLA2G4A	6
BP	GO:0006693	prostaglandin metabolic process	6/365	48/18862	0.000311434674437685	0.00104289768778429	0.000400816017005365	EDN1/MIF/PTGS1/TNFRSF1A/GSTM1/PLA2G4A	6
BP	GO:0014009	glial cell proliferation	6/365	48/18862	0.000311434674437685	0.00104289768778429	0.000400816017005365	MTOR/DICER1/IL6/NOTCH1/LEPR/CLU	6
BP	GO:0060425	lung morphogenesis	6/365	48/18862	0.000311434674437685	0.00104289768778429	0.000400816017005365	DAG1/MAPK1/MAPK3/FGFR2/BMP4/SHH	6
BP	GO:0022604	regulation of cell morphogenesis	16/365	305/18862	0.000316875659404631	0.0010604393870357	0.000407557803958978	DAG1/NEDD4L/PRKDC/CUX1/MFSD2A/ICAM1/SRC/CDKL5/CXCR4/KDR/CCL2/KIT/IL1RAPL1/VEGFA/FN1/RELN	16
BP	GO:0034754	cellular hormone metabolic process	10/365	136/18862	0.000319482630930832	0.00106848056887666	0.000410648264811717	SPP1/CYP3A5/CYP2D6/CYP19A1/TTR/CYP1A1/CYP17A1/EGR1/BMP2/SHH	10
BP	GO:1903351	cellular response to dopamine	8/365	89/18862	0.000328861894083181	0.00109914633054366	0.000422434011960045	ATF4/GSK3B/MAPK1/MAPK3/LRRK2/DRD4/CHRM3/HTR2C	8
BP	GO:0002548	monocyte chemotaxis	7/365	68/18862	0.000337428678184643	0.00112705915865885	0.000433161726403689	CCL5/HMGB1/IL6/CXCL12/CCL2/SERPINE1/TNFSF11	7
BP	GO:0003128	heart field specification	4/365	18/18862	0.00034045588437958	0.00113067645865655	0.000434551960358921	LRP2/MEF2C/BMP4/BMP2	4
BP	GO:0007039	protein catabolic process in the vacuole	4/365	18/18862	0.00034045588437958	0.00113067645865655	0.000434551960358921	LRP2/ATP13A2/CLN3/LAMP2	4
BP	GO:0007221	positive regulation of transcription of Notch receptor target	4/365	18/18862	0.00034045588437958	0.00113067645865655	0.000434551960358921	EP300/CREBBP/NOTCH1/STAT1	4
BP	GO:0010885	regulation of cholesterol storage	4/365	18/18862	0.00034045588437958	0.00113067645865655	0.000434551960358921	PPARA/PPARG/ABCA1/LPL	4
BP	GO:0032026	response to magnesium ion	4/365	18/18862	0.00034045588437958	0.00113067645865655	0.000434551960358921	SNCA/CD14/CCND1/ANK3	4
BP	GO:0033189	response to vitamin A	4/365	18/18862	0.00034045588437958	0.00113067645865655	0.000434551960358921	DNMT3A/GATA4/PPARG/CYP1A1	4
BP	GO:0035743	CD4-positive, alpha-beta T cell cytokine production	4/365	18/18862	0.00034045588437958	0.00113067645865655	0.000434551960358921	IL18/IL1R1/IL6/NLRP3	4
BP	GO:0051571	positive regulation of histone H3-K4 methylation	4/365	18/18862	0.00034045588437958	0.00113067645865655	0.000434551960358921	CTNNB1/KMT2A/DNMT1/BRCA1	4
BP	GO:2000696	regulation of epithelial cell differentiation involved in kidney development	4/365	18/18862	0.00034045588437958	0.00113067645865655	0.000434551960358921	MMP9/CTNNB1/STAT1/GDNF	4
BP	GO:1902903	regulation of supramolecular fiber organization	18/365	370/18862	0.000341387362804241	0.00113305101897108	0.000435464573186199	OCLN/EDN1/MTOR/MECP2/ICAM1/SNCA/ALMS1/SPAST/APOE/ELN/CXCL12/HSPA1B/HSPA1A/CSF3/APP/CLU/NOX4/TRPV4	18
BP	GO:0009308	amine metabolic process	11/365	163/18862	0.000341786652856019	0.00113365737709024	0.000435697614307153	MAOA/ATP7A/CLN3/MECP2/SNCA/VCAM1/DRD4/CYP1A1/GRIN2A/NQO1/DBH	11
BP	GO:0007616	long-term memory	5/365	32/18862	0.00034580022889213	0.00114334706128958	0.000439421642725577	MTOR/MECP2/APOE/SLC2A4/GRIA1	5
BP	GO:0032673	regulation of interleukin-4 production	5/365	32/18862	0.00034580022889213	0.00114334706128958	0.000439421642725577	CEBPB/DDIT3/HLA-DRB1/NLRP3/CD40LG	5
BP	GO:0043372	positive regulation of CD4-positive, alpha-beta T cell differentiation	5/365	32/18862	0.00034580022889213	0.00114334706128958	0.000439421642725577	IL18/HLA-DRB1/NLRP3/IFNG/SOCS1	5
BP	GO:0045648	positive regulation of erythrocyte differentiation	5/365	32/18862	0.00034580022889213	0.00114334706128958	0.000439421642725577	PRKDC/ETS1/STAT1/HSPA1B/HSPA1A	5
BP	GO:0098751	bone cell development	5/365	32/18862	0.00034580022889213	0.00114334706128958	0.000439421642725577	EP300/SRC/KIT/TNFSF11/FBN1	5
BP	GO:0001961	positive regulation of cytokine-mediated signaling pathway	6/365	49/18862	0.000349177896308756	0.00115160498379334	0.000442595403340319	EDN1/CASP4/IL1R1/CXCR4/HSPA1B/HSPA1A	6
BP	GO:0038066	p38MAPK cascade	6/365	49/18862	0.000349177896308756	0.00115160498379334	0.000442595403340319	GADD45A/AGER/LEP/VEGFA/XDH/BMP2	6
BP	GO:0050982	detection of mechanical stimulus	6/365	49/18862	0.000349177896308756	0.00115160498379334	0.000442595403340319	CTNNB1/CXCR4/CXCL12/KIT/CDH2/NTRK1	6
BP	GO:0060043	regulation of cardiac muscle cell proliferation	6/365	49/18862	0.000349177896308756	0.00115160498379334	0.000442595403340319	MEF2C/GJA1/MAPK1/NOTCH1/FGFR2/ERBB4	6
BP	GO:0030518	intracellular steroid hormone receptor signaling pathway	9/365	113/18862	0.000351241550886473	0.00115768153484874	0.000444930799247017	ARNTL/PARP1/EP300/CLOCK/KMT2D/SRC/BRCA1/AR/ESR2	9
BP	GO:0090559	regulation of membrane permeability	8/365	90/18862	0.000354966309304796	0.00116848658044107	0.000449083493599116	BCL2/MTOR/GSK3B/BCL2L11/SPG7/HSPA1A/BAX/CAMK2A	8
BP	GO:1903350	response to dopamine	8/365	90/18862	0.000354966309304796	0.00116848658044107	0.000449083493599116	ATF4/GSK3B/MAPK1/MAPK3/LRRK2/DRD4/CHRM3/HTR2C	8
BP	GO:0002699	positive regulation of immune effector process	13/365	219/18862	0.000357371288786251	0.0011756639380938	0.000451841961606752	XBP1/PTPRC/STXBP1/IL18/IL1R1/B2M/IL6/HLA-DRB1/NLRP3/IFNG/NOS2/C3/IL10	13
BP	GO:0051961	negative regulation of nervous system development	10/365	138/18862	0.000359147286498871	0.0011807643828738	0.000453802211385442	SPP1/NF1/RTN4/SORL1/DICER1/B2M/IL6/NOTCH1/NGFR/TLR2	10
BP	GO:0043550	regulation of lipid kinase activity	7/365	69/18862	0.000369380988815356	0.00121364726645297	0.000466440063188387	KLF4/PIK3R2/SRC/KIT/PDGFRB/SOCS1/P2RY12	7
BP	GO:0016101	diterpenoid metabolic process	9/365	114/18862	0.000374971289274561	0.0012312419874925	0.000473202227962547	LRP2/CYP3A5/CYP2D6/EGFR/ALDH3A2/APOE/LPL/TTR/CYP1A1	9
BP	GO:0030510	regulation of BMP signaling pathway	8/365	91/18862	0.000382733987240621	0.00125594337881969	0.000482695693527027	LRP2/XIAP/SORL1/GATA4/PPARG/NOTCH1/BMP4/FBN1	8
BP	GO:0003229	ventricular cardiac muscle tissue development	6/365	50/18862	0.000390408038671664	0.00127792099712788	0.000491142333630591	LRP2/CHD7/NRG1/NOTCH1/FGFR2/RYR2	6
BP	GO:0007566	embryo implantation	6/365	50/18862	0.000390408038671664	0.00127792099712788	0.000491142333630591	SPP1/MMP9/AGO2/GJA1/MMP2/VEGFA	6
BP	GO:0035176	social behavior	6/365	50/18862	0.000390408038671664	0.00127792099712788	0.000491142333630591	MTOR/MECP2/NLGN3/DRD4/NRXN1/SLC6A4	6
BP	GO:0048260	positive regulation of receptor-mediated endocytosis	6/365	50/18862	0.000390408038671664	0.00127792099712788	0.000491142333630591	TF/B2M/SERPINE1/CLU/VEGFA/C3	6
BP	GO:0006413	translational initiation	12/365	193/18862	0.000394208032561367	0.00128955302651637	0.000495612861989982	CCL5/RPS27A/EIF2AK2/RPS6/AGO2/DNAJC3/RPL5/MTOR/ATF4/HSPB1/EIF4E/PPP1R15A	12
BP	GO:0002724	regulation of T cell cytokine production	5/365	33/18862	0.000401143109988314	0.00130408884327878	0.000501199400580365	IL18/IL1R1/B2M/IL6/NLRP3	5
BP	GO:0003298	physiological muscle hypertrophy	5/365	33/18862	0.000401143109988314	0.00130408884327878	0.000501199400580365	EDN1/MTOR/GATA4/PPARA/IGF1	5
BP	GO:0003301	physiological cardiac muscle hypertrophy	5/365	33/18862	0.000401143109988314	0.00130408884327878	0.000501199400580365	EDN1/MTOR/GATA4/PPARA/IGF1	5
BP	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	5/365	33/18862	0.000401143109988314	0.00130408884327878	0.000501199400580365	CCR5/ANK2/CHD7/RYR2/CASQ2	5
BP	GO:0032633	interleukin-4 production	5/365	33/18862	0.000401143109988314	0.00130408884327878	0.000501199400580365	CEBPB/DDIT3/HLA-DRB1/NLRP3/CD40LG	5
BP	GO:0035633	maintenance of blood-brain barrier	5/365	33/18862	0.000401143109988314	0.00130408884327878	0.000501199400580365	OCLN/MFSD2A/GJA1/IL6/VEGFA	5
BP	GO:0042759	long-chain fatty acid biosynthetic process	5/365	33/18862	0.000401143109988314	0.00130408884327878	0.000501199400580365	PLP1/CYP2D6/CYP2E1/GSTM1/CYP1A1	5
BP	GO:0051954	positive regulation of amine transport	5/365	33/18862	0.000401143109988314	0.00130408884327878	0.000501199400580365	STXBP1/PINK1/CXCL12/DRD4/GDNF	5
BP	GO:0061049	cell growth involved in cardiac muscle cell development	5/365	33/18862	0.000401143109988314	0.00130408884327878	0.000501199400580365	EDN1/MTOR/GATA4/PPARA/IGF1	5
BP	GO:1902992	negative regulation of amyloid precursor protein catabolic process	5/365	33/18862	0.000401143109988314	0.00130408884327878	0.000501199400580365	RTN4/SORL1/APOE/IGF1/CLU	5
BP	GO:0030516	regulation of axon extension	8/365	92/18862	0.000412243524468411	0.00133851278354073	0.000514429525440208	L1CAM/GSK3B/RTN4/CDKL5/APOE/CXCL12/VEGFA/FN1	8
BP	GO:0051702	biological process involved in interaction with symbiont	8/365	92/18862	0.000412243524468411	0.00133851278354073	0.000514429525440208	CCL5/EP300/TARDBP/SP1/APOE/PPIB/JUN/FN1	8
BP	GO:0099003	vesicle-mediated transport in synapse	12/365	194/18862	0.00041304444480391	0.00134028185003327	0.000515109429321155	CEL/STXBP1/DNAJC5/GSK3B/SNCA/LRRK2/CANX/NLGN3/DRD4/SLC2A4/CDH2/CNR1	12
BP	GO:0050954	sensory perception of mechanical stimulus	11/365	167/18862	0.000420287720802839	0.00136294047749818	0.000523817801117998	LRP2/COL2A1/ICAM1/CHD7/DDIT3/CXCR4/CXCL12/KIT/KCNQ1/BIRC5/NTRK1	11
BP	GO:0046034	ATP metabolic process	16/365	313/18862	0.000421554137550163	0.00136620083958982	0.00052507085341917	ABCD1/NUPR1/NDUFS4/PARP1/PINK1/EP300/ATP7A/P2RX7/HDAC4/SNCA/PPARA/HSPA1B/HSPA1A/APP/IFNG/IGF1	16
BP	GO:0002544	chronic inflammatory response	4/365	19/18862	0.000424697086807828	0.00137383470479121	0.000528004770600325	CCL5/GJA1/VCAM1/IL10	4
BP	GO:0010744	positive regulation of macrophage derived foam cell differentiation	4/365	19/18862	0.000424697086807828	0.00137383470479121	0.000528004770600325	IL18/AGTR1/LPL/AGT	4
BP	GO:0035813	regulation of renal sodium excretion	4/365	19/18862	0.000424697086807828	0.00137383470479121	0.000528004770600325	EDNRB/EDN1/AGTR1/AGT	4
BP	GO:0010718	positive regulation of epithelial to mesenchymal transition	6/365	51/18862	0.000435345065688858	0.00140480645734617	0.000539908118976837	CTNNB1/MTOR/IL6/NOTCH1/BMP4/BMP2	6
BP	GO:0043370	regulation of CD4-positive, alpha-beta T cell differentiation	6/365	51/18862	0.000435345065688858	0.00140480645734617	0.000539908118976837	IL18/HMGB1/HLA-DRB1/NLRP3/IFNG/SOCS1	6
BP	GO:0071715	icosanoid transport	6/365	51/18862	0.000435345065688858	0.00140480645734617	0.000539908118976837	EDN1/LEP/DRD4/TNFSF11/PLA2G4A/NOS2	6
BP	GO:0097300	programmed necrotic cell death	6/365	51/18862	0.000435345065688858	0.00140480645734617	0.000539908118976837	NUPR1/CD14/FAS/FASLG/BAX/CAV1	6
BP	GO:0032024	positive regulation of insulin secretion	7/365	71/18862	0.000440541487950963	0.00141982398271881	0.000545679792244161	TARDBP/GJA1/CFTR/PLA2G6/GHRL/ACSL4/HLA-DRB1	7
BP	GO:0072665	protein localization to vacuole	7/365	71/18862	0.000440541487950963	0.00141982398271881	0.000545679792244161	SORT1/ATP13A2/SCARB2/RTN4/SORL1/LAMP2/CLU	7
BP	GO:0018394	peptidyl-lysine acetylation	11/365	168/18862	0.000442115556451845	0.00142402019844243	0.000547292520407757	HCFC1/EP300/CLOCK/MECP2/KMT2A/CREBBP/SNCA/MAPK3/BRCA1/BRCA2/NOS1	11
BP	GO:0010639	negative regulation of organelle organization	17/365	346/18862	0.000442972725220986	0.00142590359397702	0.000548016364276108	NUPR1/PARP1/PINK1/HNRNPA1/PHF8/HUWE1/RAD21/SNCA/ATM/SRC/BRCA1/LRRK2/TET1/BMP4/HSPA1A/IGF1/CLU	17
BP	GO:0035304	regulation of protein dephosphorylation	10/365	142/18862	0.000450855684216229	0.0014503863867165	0.000557425816023817	PTPRC/EIF2AK2/PINK1/HTT/MTOR/HSP90AB1/GSK3B/DMPK/PPP1R15A/PDGFRB	10
BP	GO:0042180	cellular ketone metabolic process	14/365	254/18862	0.000454537168074561	0.00146133141136502	0.000561632308412315	ABCD1/CLN3/MTOR/MFSD2A/PPARA/PPARG/BRCA1/ADIPOQ/CNR1/CYP17A1/EGR1/CAV1/BMP2/NQO1	14
BP	GO:0001569	branching involved in blood vessel morphogenesis	5/365	34/18862	0.000462915418554629	0.00148644128878216	0.00057128276710229	EDN1/CTNNB1/KDR/VEGFA/SHH	5
BP	GO:1904031	positive regulation of cyclin-dependent protein kinase activity	5/365	34/18862	0.000462915418554629	0.00148644128878216	0.00057128276710229	HSP90AB1/SRC/EGFR/CCND1/CDKN1A	5
BP	GO:0043903	regulation of biological process involved in symbiotic interaction	12/365	197/18862	0.000474177837696634	0.00152167185929135	0.000584822903506579	CCL5/CD4/BCL2/EIF2AK2/VAPB/PPARA/CXCR4/NOTCH1/STAT1/HLA-DRB1/CAV1/MBL2	12
BP	GO:0006720	isoprenoid metabolic process	10/365	143/18862	0.000476593560469835	0.00152638758782804	0.000586635295605533	LRP2/CYP3A5/CYP2D6/CYP2E1/EGFR/ALDH3A2/APOE/LPL/TTR/CYP1A1	10
BP	GO:0048592	eye morphogenesis	10/365	143/18862	0.000476593560469835	0.00152638758782804	0.000586635295605533	BCL2/GLI3/NF1/ATF4/MFSD2A/FASLG/BMP4/BAX/VEGFA/FBN1	10
BP	GO:1902850	microtubule cytoskeleton organization involved in mitosis	10/365	143/18862	0.000476593560469835	0.00152638758782804	0.000586635295605533	SMC1A/HTT/MECP2/DYNC1H1/GJA1/WDR62/SPAST/HSPA1B/HSPA1A/AURKA	10
BP	GO:0034308	primary alcohol metabolic process	8/365	94/18862	0.00047681385290387	0.00152638758782804	0.000586635295605533	CYP3A5/CYP2D6/ALDH2/ALDH3A2/IGF1/TTR/CYP1A1/BMP2	8
BP	GO:0002429	immune response-activating cell surface receptor signaling pathway	21/365	481/18862	0.000479736275876673	0.00153192358009735	0.000588762938995243	PIK3R2/FCGR3A/PTPRC/CD4/BCL2/IKBKG/HRAS/MEF2C/EP300/HSP90AA1/HSP90AB1/CREBBP/MAPK1/MAPK3/SRC/CTLA4/PLA2G6/HLA-DQA1/BAX/HLA-DRB1/HLA-DQB1	21
BP	GO:0002757	immune response-activating signal transduction	21/365	481/18862	0.000479736275876673	0.00153192358009735	0.000588762938995243	PIK3R2/FCGR3A/PTPRC/CD4/BCL2/IKBKG/HRAS/MEF2C/EP300/HSP90AA1/HSP90AB1/CREBBP/MAPK1/MAPK3/SRC/CTLA4/PLA2G6/HLA-DQA1/BAX/HLA-DRB1/HLA-DQB1	21
BP	GO:0014855	striated muscle cell proliferation	7/365	72/18862	0.000480006624256718	0.00153192358009735	0.000588762938995243	MEF2C/GJA1/MAPK1/NOTCH1/FGFR2/SHH/ERBB4	7
BP	GO:0015909	long-chain fatty acid transport	7/365	72/18862	0.000480006624256718	0.00153192358009735	0.000588762938995243	ABCD1/MFSD2A/PPARG/SLC2A1/APOE/DRD4/PLA2G4A	7
BP	GO:0032413	negative regulation of ion transmembrane transporter activity	7/365	72/18862	0.000480006624256718	0.00153192358009735	0.000588762938995243	MMP9/NEDD4L/ANK3/DRD4/CASQ2/CRHR1/CAV1	7
BP	GO:0018107	peptidyl-threonine phosphorylation	9/365	118/18862	0.00048350634404134	0.00154065965434754	0.000592120467280363	BCL2/PRKDC/MTOR/GSK3B/MAPK1/LRRK2/PRKCA/APP/CAMK2A	9
BP	GO:0006584	catecholamine metabolic process	6/365	52/18862	0.000484215730111139	0.00154065965434754	0.000592120467280363	MAOA/ATP7A/SNCA/DRD4/GRIN2A/DBH	6
BP	GO:0009712	catechol-containing compound metabolic process	6/365	52/18862	0.000484215730111139	0.00154065965434754	0.000592120467280363	MAOA/ATP7A/SNCA/DRD4/GRIN2A/DBH	6
BP	GO:0051703	biological process involved in intraspecies interaction between organisms	6/365	52/18862	0.000484215730111139	0.00154065965434754	0.000592120467280363	MTOR/MECP2/NLGN3/DRD4/NRXN1/SLC6A4	6
BP	GO:2000772	regulation of cellular senescence	6/365	52/18862	0.000484215730111139	0.00154065965434754	0.000592120467280363	AKT3/ARNTL/PRKDC/B2M/TERT/CDKN2A	6
BP	GO:0007006	mitochondrial membrane organization	10/365	144/18862	0.000503539205692441	0.00160116901737195	0.000615375981376385	BCL2/PINK1/BCS1L/HSP90AA1/GSK3B/BCL2L11/SPG7/HSPA1A/BAX/CAMK2A	10
BP	GO:0030641	regulation of cellular pH	8/365	95/18862	0.000512043143216988	0.00162722150066649	0.00062538871101375	BCL2/CLN3/MAPK1/MAPK3/SLC9A6/CFTR/LRRK2/FASLG	8
BP	GO:0043666	regulation of phosphoprotein phosphatase activity	9/365	119/18862	0.000514327895876161	0.00163349041687854	0.000627798038464068	PTPRC/EIF2AK2/HTT/MTOR/HSP90AB1/GSK3B/DMPK/PPP1R15A/PDGFRB	9
BP	GO:0031016	pancreas development	7/365	73/18862	0.000522239227230504	0.00164448563980235	0.000632023823514731	ARNTL/CLOCK/GSK3B/IL6/BMP4/CDH2/SHH	7
BP	GO:0042246	tissue regeneration	7/365	73/18862	0.000522239227230504	0.00164448563980235	0.000632023823514731	DAG1/GATA4/SOX2/CDKN1A/NOTCH1/IGF1/ERBB4	7
BP	GO:0048644	muscle organ morphogenesis	7/365	73/18862	0.000522239227230504	0.00164448563980235	0.000632023823514731	LRP2/CHD7/NRG1/NOTCH1/FGFR2/RYR2/BMP2	7
BP	GO:0006837	serotonin transport	4/365	20/18862	0.000522816985982254	0.00164448563980235	0.000632023823514731	SNCA/CNR1/NOS1/SLC6A4	4
BP	GO:0006925	inflammatory cell apoptotic process	4/365	20/18862	0.000522816985982254	0.00164448563980235	0.000632023823514731	MEF2C/IL6/FASLG/CDKN2A	4
BP	GO:0010878	cholesterol storage	4/365	20/18862	0.000522816985982254	0.00164448563980235	0.000632023823514731	PPARA/PPARG/ABCA1/LPL	4
BP	GO:0021871	forebrain regionalization	4/365	20/18862	0.000522816985982254	0.00164448563980235	0.000632023823514731	GLI3/BMP4/BMP2/SHH	4
BP	GO:0034104	negative regulation of tissue remodeling	4/365	20/18862	0.000522816985982254	0.00164448563980235	0.000632023823514731	P2RX7/AGER/CST3/IL6	4
BP	GO:0043691	reverse cholesterol transport	4/365	20/18862	0.000522816985982254	0.00164448563980235	0.000632023823514731	CETP/APOE/ABCA1/CLU	4
BP	GO:0060563	neuroepithelial cell differentiation	4/365	20/18862	0.000522816985982254	0.00164448563980235	0.000632023823514731	CEBPB/SERPINE1/CDH2/BMP2	4
BP	GO:0071625	vocalization behavior	4/365	20/18862	0.000522816985982254	0.00164448563980235	0.000632023823514731	GLI3/NLGN3/FOXP2/NRXN1	4
BP	GO:0090026	positive regulation of monocyte chemotaxis	4/365	20/18862	0.000522816985982254	0.00164448563980235	0.000632023823514731	CCL5/HMGB1/CXCL12/SERPINE1	4
BP	GO:0090189	regulation of branching involved in ureteric bud morphogenesis	4/365	20/18862	0.000522816985982254	0.00164448563980235	0.000632023823514731	BMP4/AGT/GDNF/VEGFA	4
BP	GO:0090280	positive regulation of calcium ion import	4/365	20/18862	0.000522816985982254	0.00164448563980235	0.000632023823514731	CXCL12/CCL2/PDGFRB/CALCR	4
BP	GO:1903206	negative regulation of hydrogen peroxide-induced cell death	4/365	20/18862	0.000522816985982254	0.00164448563980235	0.000632023823514731	PINK1/TXN/LRRK2/IL10	4
BP	GO:1903978	regulation of microglial cell activation	4/365	20/18862	0.000522816985982254	0.00164448563980235	0.000632023823514731	PTPRC/ATM/LRRK2/IL6	4
BP	GO:0043243	positive regulation of protein-containing complex disassembly	5/365	35/18862	0.000531585438058369	0.0016685292710697	0.000641264492692353	IGF1R/SETX/SPAST/ADRB2/TRPV4	5
BP	GO:0048009	insulin-like growth factor receptor signaling pathway	5/365	35/18862	0.000531585438058369	0.0016685292710697	0.000641264492692353	IGF1R/AR/IGF1/GHR/BMP2	5
BP	GO:1905207	regulation of cardiocyte differentiation	5/365	35/18862	0.000531585438058369	0.0016685292710697	0.000641264492692353	MEF2C/GATA4/EGFR/BMP4/BMP2	5
BP	GO:0051592	response to calcium ion	10/365	145/18862	0.000531736114662639	0.0016685292710697	0.000641264492692353	EDN1/MEF2C/EGFR/FOS/CCND1/TXNIP/RYR2/CASQ2/CAV1/SCN5A	10
BP	GO:0045599	negative regulation of fat cell differentiation	6/365	53/18862	0.000537253449659689	0.00168382308713701	0.00064714235253682	SORT1/ARNTL/RORA/DDIT3/IL6/ADIPOQ	6
BP	GO:0051568	histone H3-K4 methylation	6/365	53/18862	0.000537253449659689	0.00168382308713701	0.00064714235253682	CTNNB1/KMT2A/KMT2D/KMT2C/DNMT1/BRCA1	6
BP	GO:0003279	cardiac septum development	8/365	96/18862	0.000549351297334907	0.00172070897082639	0.000661318674104387	LRP2/MATR3/GATA4/ANK2/CHD7/NOTCH1/FGFR2/BMP4	8
BP	GO:0002700	regulation of production of molecular mediator of immune response	10/365	146/18862	0.000561228801463592	0.00175686097300266	0.000675212943589099	XBP1/PTPRC/PRKDC/IL18/IL1R1/B2M/IL6/NLRP3/CD40LG/IL10	10
BP	GO:0007160	cell-matrix adhesion	13/365	230/18862	0.000569017180685499	0.00178017688207286	0.000684173927888752	L1CAM/BCL2/DAG1/NF1/GSK3B/SRC/BCL2L11/VCAM1/KDR/SERPINE1/VEGFA/FN1/CDKN2A	13
BP	GO:0010596	negative regulation of endothelial cell migration	8/365	97/18862	0.000588828236671197	0.00184105555002213	0.000707571376645072	KLF4/MEF2C/MECP2/GADD45A/PPARG/HMGB1/APOE/NOTCH1	8
BP	GO:0055078	sodium ion homeostasis	6/365	54/18862	0.000594698172554479	0.00185829864785083	0.000714198402357649	EDNRB/EDN1/NEDD4L/ATP1A1/AGTR1/AGT	6
BP	GO:0007281	germ cell development	14/365	261/18862	0.000595123938679247	0.00185851950778471	0.000714283285275745	BCL2/RPS6/MTOR/KMT2D/UBE2J1/ATM/SRC/CFTR/BRCA2/BMP4/KIT/BAX/IGF1/AURKA	14
BP	GO:0001990	regulation of systemic arterial blood pressure by hormone	5/365	36/18862	0.000607633604566222	0.00189306802755929	0.000727561289677976	EDN1/HSD11B2/AGTR1/AGT/MME	5
BP	GO:0002369	T cell cytokine production	5/365	36/18862	0.000607633604566222	0.00189306802755929	0.000727561289677976	IL18/IL1R1/B2M/IL6/NLRP3	5
BP	GO:0043029	T cell homeostasis	5/365	36/18862	0.000607633604566222	0.00189306802755929	0.000727561289677976	BCL2/RPS6/BCL2L11/FAS/BAX	5
BP	GO:0043368	positive T cell selection	5/365	36/18862	0.000607633604566222	0.00189306802755929	0.000727561289677976	PTPRC/BCL2/MTOR/IL6/SHH	5
BP	GO:0000422	autophagy of mitochondrion	7/365	75/18862	0.000615561757790545	0.00191207729393217	0.000734867105505376	GABARAP/MAP1LC3A/PINK1/HTT/ATP13A2/WDR45/HUWE1	7
BP	GO:0006635	fatty acid beta-oxidation	7/365	75/18862	0.000615561757790545	0.00191207729393217	0.000734867105505376	ABCD1/MTOR/MFSD2A/PPARA/LEP/ADIPOQ/CNR1	7
BP	GO:0046902	regulation of mitochondrial membrane permeability	7/365	75/18862	0.000615561757790545	0.00191207729393217	0.000734867105505376	BCL2/GSK3B/BCL2L11/SPG7/HSPA1A/BAX/CAMK2A	7
BP	GO:0061726	mitochondrion disassembly	7/365	75/18862	0.000615561757790545	0.00191207729393217	0.000734867105505376	GABARAP/MAP1LC3A/PINK1/HTT/ATP13A2/WDR45/HUWE1	7
BP	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	7/365	75/18862	0.000615561757790545	0.00191207729393217	0.000734867105505376	MIF/BCL2/NUPR1/EP300/CDKN1A/BRCA2/BAX	7
BP	GO:0009952	anterior/posterior pattern specification	12/365	203/18862	0.000619515587464866	0.00192207740651518	0.000738710440611088	EP300/PRKDC/GLI3/MED12/GATA4/ATM/DDIT3/NOTCH1/BMP4/AURKA/BMP2/SHH	12
BP	GO:0010389	regulation of G2/M transition of mitotic cell cycle	12/365	203/18862	0.000619515587464866	0.00192207740651518	0.000738710440611088	MECP2/HSP90AA1/BRD4/DYNC1H1/RAD21/ATM/BRCA1/ALMS1/CCND1/CDKN1A/APP/AURKA	12
BP	GO:0000077	DNA damage checkpoint	10/365	148/18862	0.000624284695601566	0.00193572636065083	0.000743956132012094	EP300/CLOCK/PRKDC/GADD45A/ATM/BRCA1/CCND1/CDKN1A/BAX/AURKA	10
BP	GO:0001759	organ induction	4/365	21/18862	0.000636040501447862	0.00196635321002842	0.000755726924031999	AR/BMP4/GDNF/BMP2	4
BP	GO:0016048	detection of temperature stimulus	4/365	21/18862	0.000636040501447862	0.00196635321002842	0.000755726924031999	CXCR4/CXCL12/NGFR/NTRK1	4
BP	GO:0035812	renal sodium excretion	4/365	21/18862	0.000636040501447862	0.00196635321002842	0.000755726924031999	EDNRB/EDN1/AGTR1/AGT	4
BP	GO:0045655	regulation of monocyte differentiation	4/365	21/18862	0.000636040501447862	0.00196635321002842	0.000755726924031999	CD4/JUN/HLA-DRB1/MYC	4
BP	GO:0048485	sympathetic nervous system development	4/365	21/18862	0.000636040501447862	0.00196635321002842	0.000755726924031999	CTNNB1/NF1/GDNF/NTRK1	4
BP	GO:0018022	peptidyl-lysine methylation	9/365	123/18862	0.000654178329222968	0.00202123339737486	0.000776818981634929	CTNNB1/NSD1/MECP2/KMT2A/BRD4/KMT2D/KMT2C/DNMT1/BRCA1	9
BP	GO:0035904	aorta development	6/365	55/18862	0.000656796232655957	0.00202692893969415	0.000779007944765103	LRP2/CHD7/LEP/NOTCH1/NGFR/PDGFRB	6
BP	GO:0045620	negative regulation of lymphocyte differentiation	6/365	55/18862	0.000656796232655957	0.00202692893969415	0.000779007944765103	GLI3/HMGB1/CTLA4/BMP4/SOCS1/SHH	6
BP	GO:0001960	negative regulation of cytokine-mediated signaling pathway	7/365	76/18862	0.000666938343320413	0.00205459404881639	0.000789640453570403	CCL5/PTPRC/PPARG/IL1RN/IL6/ADIPOQ/CAV1	7
BP	GO:0060395	SMAD protein signal transduction	7/365	76/18862	0.000666938343320413	0.00205459404881639	0.000789640453570403	PARP1/FOS/TF/JUN/BMP4/GDF15/BMP2	7
BP	GO:1901983	regulation of protein acetylation	7/365	76/18862	0.000666938343320413	0.00205459404881639	0.000789640453570403	ARNTL/KMT2A/GSK3B/SNCA/MAPK3/BRCA1/NOS1	7
BP	GO:0009615	response to virus	17/365	359/18862	0.000670926060423551	0.00206566294132757	0.00079389455199344	CCL5/PTPRC/BCL2/IKBKG/EIF2AK2/DNAJC3/HSP90AA1/HSPB1/SRC/CXCR4/IL6/CXCL12/STAT1/BAX/IFNG/CLU/CYP1A1	17
BP	GO:0002702	positive regulation of production of molecular mediator of immune response	8/365	99/18862	0.000674659491339366	0.00207349840145052	0.000796905947986234	XBP1/PTPRC/IL18/IL1R1/B2M/IL6/NLRP3/IL10	8
BP	GO:0021510	spinal cord development	8/365	99/18862	0.000674659491339366	0.00207349840145052	0.000796905947986234	GLI3/NF1/MED12/MTOR/NOTCH1/GDNF/RELN/SHH	8
BP	GO:1905037	autophagosome organization	8/365	99/18862	0.000674659491339366	0.00207349840145052	0.000796905947986234	GABARAP/MAP1LC3A/NUPR1/PINK1/ATP13A2/WDR45/UBQLN2/LRRK2	8
BP	GO:0099504	synaptic vesicle cycle	11/365	177/18862	0.000684917783692212	0.00210379089192784	0.000808548236122941	CEL/STXBP1/DNAJC5/GSK3B/SNCA/LRRK2/CANX/NLGN3/SLC2A4/CDH2/CNR1	11
BP	GO:0010737	protein kinase A signaling	5/365	37/18862	0.000691551782781234	0.00211547751670192	0.000813039747082308	MIF/ADRB2/LRRK2/ADIPOQ/CALCR	5
BP	GO:0035886	vascular associated smooth muscle cell differentiation	5/365	37/18862	0.000691551782781234	0.00211547751670192	0.000813039747082308	DNMT1/NOTCH1/KIT/SOD2/VEGFA	5
BP	GO:0044003	modulation by symbiont of host process	5/365	37/18862	0.000691551782781234	0.00211547751670192	0.000813039747082308	CD4/EIF2AK2/DAG1/VAPB/BCL2L11	5
BP	GO:0070873	regulation of glycogen metabolic process	5/365	37/18862	0.000691551782781234	0.00211547751670192	0.000813039747082308	MTOR/GSK3B/HMGB1/IGF1/POMC	5
BP	GO:0071542	dopaminergic neuron differentiation	5/365	37/18862	0.000691551782781234	0.00211547751670192	0.000813039747082308	CTNNB1/GSK3B/MANF/VEGFA/SHH	5
BP	GO:1902745	positive regulation of lamellipodium organization	5/365	37/18862	0.000691551782781234	0.00211547751670192	0.000813039747082308	OCLN/ATP7A/MTOR/HDAC4/SRC	5
BP	GO:1904994	regulation of leukocyte adhesion to vascular endothelial cell	5/365	37/18862	0.000691551782781234	0.00211547751670192	0.000813039747082308	KLF4/ICAM1/ETS1/IL6/CXCL12	5
BP	GO:0030048	actin filament-based movement	10/365	150/18862	0.000693083594436945	0.00211892496102977	0.000814364700546607	NEDD4L/ATP1A1/GJA1/GATA4/ANK2/KCNQ1/RYR2/CAV1/KCNH2/SCN5A	10
BP	GO:0051053	negative regulation of DNA metabolic process	9/365	124/18862	0.000693602743693412	0.00211927423262774	0.000814498935814735	PARP1/KMT2A/HNRNPA1/GJA1/ATM/PPARG/SRC/CDKN1A/ADIPOQ	9
BP	GO:0043687	post-translational protein modification	17/365	361/18862	0.000713675671383554	0.00217933399301139	0.000837581654494854	SPP1/DNAJC3/SERPINA1/CST3/TF/APOE/IL6/BMP4/C4A/CP/APP/CDH2/ADAM10/FBN1/FN1/C3/PROC	17
BP	GO:0006939	smooth muscle contraction	8/365	100/18862	0.000721204971390022	0.00220104187769993	0.000845924628096567	EDNRB/EDN1/ADRB2/KIT/GHRL/GDNF/CHRM3/CAV1	8
BP	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	6/365	56/18862	0.00072380019469282	0.00220767495281015	0.000848473912438952	EP300/GADD45A/ATM/CDKN1A/BAX/AURKA	6
BP	GO:0001952	regulation of cell-matrix adhesion	9/365	125/18862	0.00073494540932708	0.00223905952992895	0.000860535921343086	BCL2/DAG1/NF1/GSK3B/SRC/KDR/SERPINE1/VEGFA/CDKN2A	9
BP	GO:0002705	positive regulation of leukocyte mediated immunity	9/365	125/18862	0.00073494540932708	0.00223905952992895	0.000860535921343086	PTPRC/IL18/IL1R1/B2M/IL6/HLA-DRB1/NLRP3/NOS2/C3	9
BP	GO:0090090	negative regulation of canonical Wnt signaling pathway	11/365	179/18862	0.000751738034198901	0.00228888706864284	0.000879686098621659	GLI3/GSK3B/DDIT3/SOX2/APOE/NOTCH1/CDH2/EGR1/CAV1/BMP2/SHH	11
BP	GO:0010288	response to lead ion	4/365	22/18862	0.000765603634691242	0.0023109396908731	0.000888161564921365	MAP1LC3A/DNMT3A/ATP7A/APP	4
BP	GO:0021801	cerebral cortex radial glia guided migration	4/365	22/18862	0.000765603634691242	0.0023109396908731	0.000888161564921365	GLI3/RTN4/P2RY12/FOXG1	4
BP	GO:0022030	telencephalon glial cell migration	4/365	22/18862	0.000765603634691242	0.0023109396908731	0.000888161564921365	GLI3/RTN4/P2RY12/FOXG1	4
BP	GO:0030810	positive regulation of nucleotide biosynthetic process	4/365	22/18862	0.000765603634691242	0.0023109396908731	0.000888161564921365	PINK1/PPARA/NOS2/NOS1	4
BP	GO:0031281	positive regulation of cyclase activity	4/365	22/18862	0.000765603634691242	0.0023109396908731	0.000888161564921365	NF1/MAPK3/NOS2/NOS1	4
BP	GO:0035584	calcium-mediated signaling using intracellular calcium source	4/365	22/18862	0.000765603634691242	0.0023109396908731	0.000888161564921365	PTPRC/VCAM1/KDR/RYR2	4
BP	GO:0043369	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment	4/365	22/18862	0.000765603634691242	0.0023109396908731	0.000888161564921365	BCL2/MTOR/IL6/SHH	4
BP	GO:0044062	regulation of excretion	4/365	22/18862	0.000765603634691242	0.0023109396908731	0.000888161564921365	EDNRB/EDN1/AGTR1/AGT	4
BP	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	4/365	22/18862	0.000765603634691242	0.0023109396908731	0.000888161564921365	ANK2/KCNQ1/KCNH2/SCN5A	4
BP	GO:0060575	intestinal epithelial cell differentiation	4/365	22/18862	0.000765603634691242	0.0023109396908731	0.000888161564921365	GATA4/SRC/CDKN1A/NPY	4
BP	GO:0090312	positive regulation of protein deacetylation	4/365	22/18862	0.000765603634691242	0.0023109396908731	0.000888161564921365	PINK1/LRRK2/IFNG/VEGFA	4
BP	GO:1900373	positive regulation of purine nucleotide biosynthetic process	4/365	22/18862	0.000765603634691242	0.0023109396908731	0.000888161564921365	PINK1/PPARA/NOS2/NOS1	4
BP	GO:1900543	negative regulation of purine nucleotide metabolic process	4/365	22/18862	0.000765603634691242	0.0023109396908731	0.000888161564921365	NUPR1/PARP1/HDAC4/PPARA	4
BP	GO:1901032	negative regulation of response to reactive oxygen species	4/365	22/18862	0.000765603634691242	0.0023109396908731	0.000888161564921365	PINK1/TXN/LRRK2/IL10	4
BP	GO:1903203	regulation of oxidative stress-induced neuron death	4/365	22/18862	0.000765603634691242	0.0023109396908731	0.000888161564921365	PARP1/PINK1/ATF4/IL10	4
BP	GO:0001660	fever generation	3/365	10/18862	0.000779523221665213	0.00231526875493395	0.000889825350577957	EDNRB/TNFSF11/CNR1	3
BP	GO:0008343	adult feeding behavior	3/365	10/18862	0.000779523221665213	0.00231526875493395	0.000889825350577957	LEP/GHRL/NPY	3
BP	GO:0010887	negative regulation of cholesterol storage	3/365	10/18862	0.000779523221665213	0.00231526875493395	0.000889825350577957	PPARA/PPARG/ABCA1	3
BP	GO:0014877	response to muscle inactivity involved in regulation of muscle adaptation	3/365	10/18862	0.000779523221665213	0.00231526875493395	0.000889825350577957	DAG1/HDAC4/SCN5A	3
BP	GO:0014894	response to denervation involved in regulation of muscle adaptation	3/365	10/18862	0.000779523221665213	0.00231526875493395	0.000889825350577957	DAG1/HDAC4/SCN5A	3
BP	GO:0021859	pyramidal neuron differentiation	3/365	10/18862	0.000779523221665213	0.00231526875493395	0.000889825350577957	ATP7A/FGFR2/FOXG1	3
BP	GO:0021978	telencephalon regionalization	3/365	10/18862	0.000779523221665213	0.00231526875493395	0.000889825350577957	BMP4/BMP2/SHH	3
BP	GO:0031943	regulation of glucocorticoid metabolic process	3/365	10/18862	0.000779523221665213	0.00231526875493395	0.000889825350577957	ATP1A1/STUB1/BMP2	3
BP	GO:0033083	regulation of immature T cell proliferation	3/365	10/18862	0.000779523221665213	0.00231526875493395	0.000889825350577957	GNRH1/BMP4/SHH	3
BP	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway	3/365	10/18862	0.000779523221665213	0.00231526875493395	0.000889825350577957	PARP1/KMT2D/AR	3
BP	GO:0035933	glucocorticoid secretion	3/365	10/18862	0.000779523221665213	0.00231526875493395	0.000889825350577957	GHRL/POMC/CRHR1	3
BP	GO:0036500	ATF6-mediated unfolded protein response	3/365	10/18862	0.000779523221665213	0.00231526875493395	0.000889825350577957	XBP1/ATF6/DDIT3	3
BP	GO:0040015	negative regulation of multicellular organism growth	3/365	10/18862	0.000779523221665213	0.00231526875493395	0.000889825350577957	RAI1/ADRB2/GDF15	3
BP	GO:0044803	multi-organism membrane organization	3/365	10/18862	0.000779523221665213	0.00231526875493395	0.000889825350577957	CCR5/CD4/CXCR4	3
BP	GO:0048755	branching morphogenesis of a nerve	3/365	10/18862	0.000779523221665213	0.00231526875493395	0.000889825350577957	RTN4/LRRK2/FGFR2	3
BP	GO:0051712	positive regulation of killing of cells of other organism	3/365	10/18862	0.000779523221665213	0.00231526875493395	0.000889825350577957	BCL2L11/IFNG/NOS2	3
BP	GO:0060272	embryonic skeletal joint morphogenesis	3/365	10/18862	0.000779523221665213	0.00231526875493395	0.000889825350577957	COL2A1/CTNNB1/BMP4	3
BP	GO:0060513	prostatic bud formation	3/365	10/18862	0.000779523221665213	0.00231526875493395	0.000889825350577957	AR/BMP4/SHH	3
BP	GO:0060736	prostate gland growth	3/365	10/18862	0.000779523221665213	0.00231526875493395	0.000889825350577957	AR/FGFR2/SHH	3
BP	GO:0060742	epithelial cell differentiation involved in prostate gland development	3/365	10/18862	0.000779523221665213	0.00231526875493395	0.000889825350577957	NOTCH1/AR/FGFR2	3
BP	GO:0090209	negative regulation of triglyceride metabolic process	3/365	10/18862	0.000779523221665213	0.00231526875493395	0.000889825350577957	SORL1/PIK3CG/APOE	3
BP	GO:0097105	presynaptic membrane assembly	3/365	10/18862	0.000779523221665213	0.00231526875493395	0.000889825350577957	CEL/NLGN3/IL1RAPL1	3
BP	GO:1901725	regulation of histone deacetylase activity	3/365	10/18862	0.000779523221665213	0.00231526875493395	0.000889825350577957	PINK1/LRRK2/VEGFA	3
BP	GO:1902337	regulation of apoptotic process involved in morphogenesis	3/365	10/18862	0.000779523221665213	0.00231526875493395	0.000889825350577957	TNFRSF1A/NOTCH1/BAX	3
BP	GO:1905461	positive regulation of vascular associated smooth muscle cell apoptotic process	3/365	10/18862	0.000779523221665213	0.00231526875493395	0.000889825350577957	ATF4/PPARG/SOD2	3
BP	GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin	3/365	10/18862	0.000779523221665213	0.00231526875493395	0.000889825350577957	NOTCH1/EPCAM/VEGFA	3
BP	GO:2000659	regulation of interleukin-1-mediated signaling pathway	3/365	10/18862	0.000779523221665213	0.00231526875493395	0.000889825350577957	IL1R1/IL1RN/IL6	3
BP	GO:0001570	vasculogenesis	7/365	78/18862	0.000779866032661168	0.00231526875493395	0.000889825350577957	KDR/NOTCH1/PDGFRB/VEGFA/CAV1/XDH/SHH	7
BP	GO:0050772	positive regulation of axonogenesis	7/365	78/18862	0.000779866032661168	0.00231526875493395	0.000889825350577957	L1CAM/NGF/CDKL5/CXCL12/NGFR/VEGFA/FN1	7
BP	GO:0001504	neurotransmitter uptake	5/365	38/18862	0.000783842529205455	0.00232180633721638	0.000892337934239791	SNCA/DRD4/GDNF/NOS1/SLC6A4	5
BP	GO:0007618	mating	5/365	38/18862	0.000783842529205455	0.00232180633721638	0.000892337934239791	EDNRB/HDAC4/APP/CNR1/SLC6A4	5
BP	GO:0045823	positive regulation of heart contraction	5/365	38/18862	0.000783842529205455	0.00232180633721638	0.000892337934239791	NPPA/EDN1/ATP1A1/KCNQ1/RYR2	5
BP	GO:0051154	negative regulation of striated muscle cell differentiation	5/365	38/18862	0.000783842529205455	0.00232180633721638	0.000892337934239791	XBP1/HDAC4/PPARA/NOTCH1/BMP2	5
BP	GO:0002260	lymphocyte homeostasis	6/365	57/18862	0.000795968690052943	0.00235372888346729	0.00090460670038131	BCL2/MEF2C/RPS6/BCL2L11/FAS/BAX	6
BP	GO:0010043	response to zinc ion	6/365	57/18862	0.000795968690052943	0.00235372888346729	0.00090460670038131	PARP1/ATP7A/ATP13A2/VCAM1/BGLAP/SOD2	6
BP	GO:0030520	intracellular estrogen receptor signaling pathway	6/365	57/18862	0.000795968690052943	0.00235372888346729	0.00090460670038131	PARP1/KMT2D/SRC/BRCA1/AR/ESR2	6
BP	GO:0016051	carbohydrate biosynthetic process	12/365	209/18862	0.000800533193232918	0.00236588974216888	0.000909280473278913	EP300/MTOR/ATF4/GSK3B/SNCA/PPARA/ATF3/SLC2A1/LEP/LEPR/IGF1/ADIPOQ	12
BP	GO:0001837	epithelial to mesenchymal transition	10/365	153/18862	0.000807915071839006	0.00238635862641386	0.000917147262851575	DAG1/CTNNB1/MTOR/GSK3B/RTN4/IL6/NOTCH1/FGFR2/BMP4/BMP2	10
BP	GO:0006814	sodium ion transport	13/365	239/18862	0.000813329761827165	0.00239964372796132	0.000922253115084383	NEDD4L/ATP1A1/P2RX7/SLC9A6/SLC6A8/ADRB2/DMPK/ANK3/DRD4/SCN5A/SLC6A1/NOS1/SLC6A4	13
BP	GO:0038093	Fc receptor signaling pathway	13/365	239/18862	0.000813329761827165	0.00239964372796132	0.000922253115084383	PIK3R2/FCGR3A/PTPRC/IKBKG/HSP90AA1/HSP90AB1/MAPK1/MAPK3/SRC/FOS/PLA2G6/JUN/KIT	13
BP	GO:0044773	mitotic DNA damage checkpoint	8/365	102/18862	0.000822050440415537	0.00242400676345629	0.000931616540628075	EP300/PRKDC/GADD45A/ATM/CCND1/CDKN1A/BAX/AURKA	8
BP	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	9/365	127/18862	0.000823664528034759	0.00242603271791442	0.000932395174051136	RPS27A/STUB1/EP300/HSP90AB1/CREBBP/PPARA/HSPA1A/FBN1/CAV1	9
BP	GO:0018210	peptidyl-threonine modification	9/365	127/18862	0.000823664528034759	0.00242603271791442	0.000932395174051136	BCL2/PRKDC/MTOR/GSK3B/MAPK1/LRRK2/PRKCA/APP/CAMK2A	9
BP	GO:0046486	glycerolipid metabolic process	19/365	433/18862	0.000830718561588027	0.00244543360593461	0.000939851501506554	PIK3R2/CLN3/MECP2/MFSD2A/SORL1/ATM/CYP2E1/PIK3CG/CETP/PLA2G6/APOE/ACSL4/PDGFRB/LPL/SOCS1/PLA2G4A/HTR2C/CAV1/C3	19
BP	GO:0001910	regulation of leukocyte mediated cytotoxicity	7/365	79/18862	0.000841725415398603	0.00247505102482938	0.000951234339933017	PTPRC/ICAM1/AGER/LEP/B2M/HLA-DRB1/NOS2	7
BP	GO:0032204	regulation of telomere maintenance	7/365	79/18862	0.000841725415398603	0.00247505102482938	0.000951234339933017	PARP1/HNRNPA1/MAPK1/ATM/MAPK3/SRC/MYC	7
BP	GO:0034401	chromatin organization involved in regulation of transcription	10/365	154/18862	0.000849500487752882	0.00249651069786557	0.000959481918553006	DNMT3A/MECP2/PHF8/ARID1B/KMT2D/DNMT1/HMGB1/MTHFR/TET1/CDKN2A	10
BP	GO:0010574	regulation of vascular endothelial growth factor production	6/365	58/18862	0.000873566243617391	0.00256435542293518	0.000985556626355837	ATF4/RORA/GATA4/BRCA1/IL6/C3	6
BP	GO:0060038	cardiac muscle cell proliferation	6/365	58/18862	0.000873566243617391	0.00256435542293518	0.000985556626355837	MEF2C/GJA1/MAPK1/NOTCH1/FGFR2/ERBB4	6
BP	GO:0070498	interleukin-1-mediated signaling pathway	8/365	103/18862	0.000876555067836861	0.00257168678534649	0.000988374282886619	RPS27A/NFKBIA/IKBKG/MAPK3/IL1R1/IL1RN/IL6/EGR1	8
BP	GO:0021795	cerebral cortex cell migration	5/365	39/18862	0.000885018345114928	0.00258492523344394	0.00099346220483707	GLI3/RTN4/P2RY12/FOXG1/RELN	5
BP	GO:0030501	positive regulation of bone mineralization	5/365	39/18862	0.000885018345114928	0.00258492523344394	0.00099346220483707	MEF2C/P2RX7/ADRB2/BMP4/BMP2	5
BP	GO:0033146	regulation of intracellular estrogen receptor signaling pathway	5/365	39/18862	0.000885018345114928	0.00258492523344394	0.00099346220483707	PARP1/KMT2D/SRC/BRCA1/AR	5
BP	GO:0045773	positive regulation of axon extension	5/365	39/18862	0.000885018345114928	0.00258492523344394	0.00099346220483707	L1CAM/CDKL5/CXCL12/VEGFA/FN1	5
BP	GO:0086091	regulation of heart rate by cardiac conduction	5/365	39/18862	0.000885018345114928	0.00258492523344394	0.00099346220483707	ANK2/KCNQ1/CAV1/KCNH2/SCN5A	5
BP	GO:0090207	regulation of triglyceride metabolic process	5/365	39/18862	0.000885018345114928	0.00258492523344394	0.00099346220483707	MFSD2A/SORL1/PIK3CG/APOE/C3	5
BP	GO:1905521	regulation of macrophage migration	5/365	39/18862	0.000885018345114928	0.00258492523344394	0.00099346220483707	CCL5/MIF/MAPK1/MAPK3/P2RY12	5
BP	GO:2000516	positive regulation of CD4-positive, alpha-beta T cell activation	5/365	39/18862	0.000885018345114928	0.00258492523344394	0.00099346220483707	IL18/HLA-DRB1/NLRP3/IFNG/SOCS1	5
BP	GO:0001942	hair follicle development	7/365	80/18862	0.000907393197930055	0.00264879866032677	0.00101801062684964	BCL2/ATP7A/EGFR/NOTCH1/FGFR2/NGFR/SHH	7
BP	GO:0003071	renal system process involved in regulation of systemic arterial blood pressure	4/365	23/18862	0.000912749508706488	0.00264965664368816	0.00101834037489453	HSD11B2/GJA1/AGTR1/AGT	4
BP	GO:0042026	protein refolding	4/365	23/18862	0.000912749508706488	0.00264965664368816	0.00101834037489453	HSP90AA1/B2M/HSPA1B/HSPA1A	4
BP	GO:0042738	exogenous drug catabolic process	4/365	23/18862	0.000912749508706488	0.00264965664368816	0.00101834037489453	CYP2D6/CYP2U1/CYP2E1/NOS1	4
BP	GO:0045980	negative regulation of nucleotide metabolic process	4/365	23/18862	0.000912749508706488	0.00264965664368816	0.00101834037489453	NUPR1/PARP1/HDAC4/PPARA	4
BP	GO:0051043	regulation of membrane protein ectodomain proteolysis	4/365	23/18862	0.000912749508706488	0.00264965664368816	0.00101834037489453	FURIN/APOE/IFNG/IL10	4
BP	GO:0060561	apoptotic process involved in morphogenesis	4/365	23/18862	0.000912749508706488	0.00264965664368816	0.00101834037489453	TNFRSF1A/BCL2L11/NOTCH1/BAX	4
BP	GO:0060571	morphogenesis of an epithelial fold	4/365	23/18862	0.000912749508706488	0.00264965664368816	0.00101834037489453	AR/FGFR2/BMP4/SHH	4
BP	GO:0061050	regulation of cell growth involved in cardiac muscle cell development	4/365	23/18862	0.000912749508706488	0.00264965664368816	0.00101834037489453	EDN1/MTOR/PPARA/IGF1	4
BP	GO:0070841	inclusion body assembly	4/365	23/18862	0.000912749508706488	0.00264965664368816	0.00101834037489453	SORL1/HSPA1B/HSPA1A/CLU	4
BP	GO:0071157	negative regulation of cell cycle arrest	4/365	23/18862	0.000912749508706488	0.00264965664368816	0.00101834037489453	MIF/HSP90AB1/CCND1/ADAM10	4
BP	GO:0031570	DNA integrity checkpoint	10/365	156/18862	0.000937955460877309	0.00272131867086022	0.00104588218329825	EP300/CLOCK/PRKDC/GADD45A/ATM/BRCA1/CCND1/CDKN1A/BAX/AURKA	10
BP	GO:0006839	mitochondrial transport	14/365	274/18862	0.000955039400290404	0.0027685027220289	0.00106401639116651	BCL2/PINK1/PSEN2/BCS1L/HSP90AA1/GSK3B/HUWE1/BCL2L11/SPG7/UCP2/LRRK2/HSPA1A/BAX/CAMK2A	14
BP	GO:0006940	regulation of smooth muscle contraction	6/365	59/18862	0.000956863092118894	0.0027685027220289	0.00106401639116651	EDN1/ADRB2/KIT/GHRL/CHRM3/CAV1	6
BP	GO:0048488	synaptic vesicle endocytosis	6/365	59/18862	0.000956863092118894	0.0027685027220289	0.00106401639116651	CEL/SNCA/LRRK2/CANX/NLGN3/SLC2A4	6
BP	GO:0048663	neuron fate commitment	6/365	59/18862	0.000956863092118894	0.0027685027220289	0.00106401639116651	GLI3/NOTCH1/BMP4/SATB2/FOXG1/SHH	6
BP	GO:0140238	presynaptic endocytosis	6/365	59/18862	0.000956863092118894	0.0027685027220289	0.00106401639116651	CEL/SNCA/LRRK2/CANX/NLGN3/SLC2A4	6
BP	GO:1903844	regulation of cellular response to transforming growth factor beta stimulus	9/365	130/18862	0.00097291333855587	0.00281338586408918	0.00108126629251542	RPS27A/STUB1/EP300/HSP90AB1/CREBBP/PPARA/HSPA1A/FBN1/CAV1	9
BP	GO:0021954	central nervous system neuron development	7/365	81/18862	0.000977032226980841	0.00282217807727247	0.00108464539663087	ATP7A/HSP90AA1/HSP90AB1/LEP/FGFR2/FOXG1/NPY	7
BP	GO:0031110	regulation of microtubule polymerization or depolymerization	7/365	81/18862	0.000977032226980841	0.00282217807727247	0.00108464539663087	OCLN/MECP2/SNCA/SPAST/HSPA1B/HSPA1A/TRPV4	7
BP	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	13/365	244/18862	0.000983553324928189	0.00283944738150808	0.00109128249423042	CD4/IKBKG/PINK1/BRD4/RORA/TNFRSF1A/HSPB1/GJA1/FASLG/STAT1/HLA-DRB1/TNFSF11/ADIPOQ	13
BP	GO:0002224	toll-like receptor signaling pathway	10/365	157/18862	0.000984935961132404	0.0028418377220938	0.00109220117187645	RPS27A/NFKBIA/IKBKG/RPS6KA3/RTN4/CD14/HMGB1/TLR2/CTSB/CAV1	10
BP	GO:0030308	negative regulation of cell growth	11/365	185/18862	0.000985467226901079	0.0028418377220938	0.00109220117187645	SPP1/BCL2/RTN4/GJA1/PPARA/PPARG/CDKN1A/HSPA1B/HSPA1A/ESR2/CDKN2A	11
BP	GO:0016050	vesicle organization	16/365	339/18862	0.000991383237048833	0.00285532889043582	0.00109738622159219	SORT1/STXBP1/BCL2/ZEB2/TRAPPC9/ATP13A2/CLN3/SCARB2/VAPB/SNCA/SERPINA1/ABCA1/FASLG/SLC2A4/GRIA1/CAV1	16
BP	GO:0048193	Golgi vesicle transport	17/365	372/18862	0.00099291223987437	0.00285532889043582	0.00109738622159219	SORT1/HTT/TRAPPC9/CLN3/VAPB/CUX1/DYNC1H1/SORL1/ANK2/SPAST/SERPINA1/MIA2/LRRK2/BGLAP/ANK3/GRIA1/PROC	17
BP	GO:0062207	regulation of pattern recognition receptor signaling pathway	8/365	105/18862	0.000994256349308592	0.00285532889043582	0.00109738622159219	XIAP/RTN4/CD14/HMGB1/HSPA1B/HSPA1A/TLR2/CAV1	8
BP	GO:0006308	DNA catabolic process	5/365	40/18862	0.000995600921865756	0.00285532889043582	0.00109738622159219	ATM/DICER1/HMGB1/IL6/BAX	5
BP	GO:0006623	protein targeting to vacuole	5/365	40/18862	0.000995600921865756	0.00285532889043582	0.00109738622159219	SORT1/SCARB2/SORL1/LAMP2/CLU	5
BP	GO:0030890	positive regulation of B cell proliferation	5/365	40/18862	0.000995600921865756	0.00285532889043582	0.00109738622159219	PTPRC/MIF/BCL2/MEF2C/CDKN1A	5
BP	GO:0032735	positive regulation of interleukin-12 production	5/365	40/18862	0.000995600921865756	0.00285532889043582	0.00109738622159219	HMGB1/AGER/TLR2/IFNG/CD40LG	5
BP	GO:0070296	sarcoplasmic reticulum calcium ion transport	5/365	40/18862	0.000995600921865756	0.00285532889043582	0.00109738622159219	CCR5/ANK2/CHD7/RYR2/CASQ2	5
BP	GO:1904037	positive regulation of epithelial cell apoptotic process	5/365	40/18862	0.000995600921865756	0.00285532889043582	0.00109738622159219	SORT1/IL6/FASLG/CCL2/CD40LG	5
BP	GO:2000008	regulation of protein localization to cell surface	5/365	40/18862	0.000995600921865756	0.00285532889043582	0.00109738622159219	NEDD4L/CTNNB1/HSP90AB1/ASTN2/ERBB4	5
BP	GO:0072329	monocarboxylic acid catabolic process	9/365	131/18862	0.00102727494014943	0.00294455478463424	0.00113167833667237	CEL/ABCD1/MTOR/MFSD2A/PPARA/LEP/ALDH3A2/ADIPOQ/CNR1	9
BP	GO:0050792	regulation of viral process	11/365	186/18862	0.0010297114662738	0.00294992327010239	0.00113374160230993	CCL5/CD4/BCL2/EIF2AK2/VAPB/PPARA/CXCR4/NOTCH1/STAT1/HLA-DRB1/MBL2	11
BP	GO:0007588	excretion	6/365	60/18862	0.00104613499450636	0.00296663212525997	0.00114016330297283	EDNRB/EDN1/NEDD4L/CLN3/AGTR1/AGT	6
BP	GO:0016239	positive regulation of macroautophagy	6/365	60/18862	0.00104613499450636	0.00296663212525997	0.00114016330297283	IKBKG/PINK1/HTT/MAPK3/ADRB2/KDR	6
BP	GO:0032615	interleukin-12 production	6/365	60/18862	0.00104613499450636	0.00296663212525997	0.00114016330297283	HMGB1/AGER/TLR2/IFNG/CD40LG/IL10	6
BP	GO:0032653	regulation of interleukin-10 production	6/365	60/18862	0.00104613499450636	0.00296663212525997	0.00114016330297283	HMGB1/AGER/IL6/TLR2/HLA-DRB1/CD40LG	6
BP	GO:0032655	regulation of interleukin-12 production	6/365	60/18862	0.00104613499450636	0.00296663212525997	0.00114016330297283	HMGB1/AGER/TLR2/IFNG/CD40LG/IL10	6
BP	GO:0032890	regulation of organic acid transport	6/365	60/18862	0.00104613499450636	0.00296663212525997	0.00114016330297283	EDN1/STXBP1/PPARA/LEP/TNFSF11/PLA2G4A	6
BP	GO:0046888	negative regulation of hormone secretion	6/365	60/18862	0.00104613499450636	0.00296663212525997	0.00114016330297283	EDN1/GJA1/UCP2/LEP/GHRL/ADIPOQ	6
BP	GO:0051926	negative regulation of calcium ion transport	6/365	60/18862	0.00104613499450636	0.00296663212525997	0.00114016330297283	BCL2/ICAM1/DRD4/CASQ2/CRHR1/NOS1	6
BP	GO:0140115	export across plasma membrane	6/365	60/18862	0.00104613499450636	0.00296663212525997	0.00114016330297283	NPPA/ATP1A1/GJA1/ABCA1/KCNQ1/KCNH2	6
BP	GO:1904356	regulation of telomere maintenance via telomere lengthening	6/365	60/18862	0.00104613499450636	0.00296663212525997	0.00114016330297283	PARP1/HNRNPA1/MAPK1/ATM/MAPK3/SRC	6
BP	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	6/365	60/18862	0.00104613499450636	0.00296663212525997	0.00114016330297283	BCL2/NUPR1/BCL2L11/DDIT3/BAX/CAV1	6
BP	GO:0006970	response to osmotic stress	7/365	82/18862	0.00105080873615388	0.00296663212525997	0.00114016330297283	CLN3/HSP90AB1/EGFR/SLC2A1/BAX/SLC2A4/TRPV4	7
BP	GO:0071158	positive regulation of cell cycle arrest	7/365	82/18862	0.00105080873615388	0.00296663212525997	0.00114016330297283	EP300/GADD45A/ATM/BRCA1/CDKN1A/BAX/AURKA	7
BP	GO:0003139	secondary heart field specification	3/365	11/18862	0.00105651552951559	0.00296663212525997	0.00114016330297283	LRP2/MEF2C/BMP4	3
BP	GO:0014870	response to muscle inactivity	3/365	11/18862	0.00105651552951559	0.00296663212525997	0.00114016330297283	DAG1/HDAC4/SCN5A	3
BP	GO:0030422	production of siRNA involved in RNA interference	3/365	11/18862	0.00105651552951559	0.00296663212525997	0.00114016330297283	AGO2/DICER1/TERT	3
BP	GO:0032306	regulation of prostaglandin secretion	3/365	11/18862	0.00105651552951559	0.00296663212525997	0.00114016330297283	EDN1/TNFSF11/PLA2G4A	3
BP	GO:0032308	positive regulation of prostaglandin secretion	3/365	11/18862	0.00105651552951559	0.00296663212525997	0.00114016330297283	EDN1/TNFSF11/PLA2G4A	3
BP	GO:0033079	immature T cell proliferation	3/365	11/18862	0.00105651552951559	0.00296663212525997	0.00114016330297283	GNRH1/BMP4/SHH	3
BP	GO:0033197	response to vitamin E	3/365	11/18862	0.00105651552951559	0.00296663212525997	0.00114016330297283	PPARG/CCND1/LEP	3
BP	GO:0034975	protein folding in endoplasmic reticulum	3/365	11/18862	0.00105651552951559	0.00296663212525997	0.00114016330297283	DNAJC3/CANX/DNAJC10	3
BP	GO:0035747	natural killer cell chemotaxis	3/365	11/18862	0.00105651552951559	0.00296663212525997	0.00114016330297283	CCL5/PIK3CG/CCL2	3
BP	GO:0045060	negative thymic T cell selection	3/365	11/18862	0.00105651552951559	0.00296663212525997	0.00114016330297283	PTPRC/GLI3/SHH	3
BP	GO:0045348	positive regulation of MHC class II biosynthetic process	3/365	11/18862	0.00105651552951559	0.00296663212525997	0.00114016330297283	XBP1/IFNG/IL10	3
BP	GO:0045657	positive regulation of monocyte differentiation	3/365	11/18862	0.00105651552951559	0.00296663212525997	0.00114016330297283	CD4/JUN/HLA-DRB1	3
BP	GO:0051610	serotonin uptake	3/365	11/18862	0.00105651552951559	0.00296663212525997	0.00114016330297283	SNCA/NOS1/SLC6A4	3
BP	GO:0060174	limb bud formation	3/365	11/18862	0.00105651552951559	0.00296663212525997	0.00114016330297283	COL2A1/FGFR2/SHH	3
BP	GO:0061307	cardiac neural crest cell differentiation involved in heart development	3/365	11/18862	0.00105651552951559	0.00296663212525997	0.00114016330297283	MAPK1/MAPK3/BMP4	3
BP	GO:0061308	cardiac neural crest cell development involved in heart development	3/365	11/18862	0.00105651552951559	0.00296663212525997	0.00114016330297283	MAPK1/MAPK3/BMP4	3
BP	GO:0072110	glomerular mesangial cell proliferation	3/365	11/18862	0.00105651552951559	0.00296663212525997	0.00114016330297283	BMP4/PDGFRB/EGR1	3
BP	GO:0086070	SA node cell to atrial cardiac muscle cell communication	3/365	11/18862	0.00105651552951559	0.00296663212525997	0.00114016330297283	ANK2/RYR2/SCN5A	3
BP	GO:0090084	negative regulation of inclusion body assembly	3/365	11/18862	0.00105651552951559	0.00296663212525997	0.00114016330297283	SORL1/HSPA1B/HSPA1A	3
BP	GO:0097090	presynaptic membrane organization	3/365	11/18862	0.00105651552951559	0.00296663212525997	0.00114016330297283	CEL/NLGN3/IL1RAPL1	3
BP	GO:0099624	atrial cardiac muscle cell membrane repolarization	3/365	11/18862	0.00105651552951559	0.00296663212525997	0.00114016330297283	NPPA/KCNQ1/SCN5A	3
BP	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway	3/365	11/18862	0.00105651552951559	0.00296663212525997	0.00114016330297283	CASP4/HSPA1B/HSPA1A	3
BP	GO:1904181	positive regulation of membrane depolarization	3/365	11/18862	0.00105651552951559	0.00296663212525997	0.00114016330297283	PARP1/KDR/ANK3	3
BP	GO:1904748	regulation of apoptotic process involved in development	3/365	11/18862	0.00105651552951559	0.00296663212525997	0.00114016330297283	TNFRSF1A/NOTCH1/BAX	3
BP	GO:0044774	mitotic DNA integrity checkpoint	8/365	106/18862	0.00105767089372207	0.00296828389155029	0.00114079812496281	EP300/PRKDC/GADD45A/ATM/CCND1/CDKN1A/BAX/AURKA	8
BP	GO:0006309	apoptotic DNA fragmentation	4/365	24/18862	0.00107872464958773	0.00301283074489978	0.00115791878074603	DICER1/HMGB1/IL6/BAX	4
BP	GO:0045662	negative regulation of myoblast differentiation	4/365	24/18862	0.00107872464958773	0.00301283074489978	0.00115791878074603	IL18/DDIT3/NOTCH1/BMP4	4
BP	GO:0045821	positive regulation of glycolytic process	4/365	24/18862	0.00107872464958773	0.00301283074489978	0.00115791878074603	P2RX7/APP/IFNG/IGF1	4
BP	GO:0060396	growth hormone receptor signaling pathway	4/365	24/18862	0.00107872464958773	0.00301283074489978	0.00115791878074603	GHRL/PRL/GHR/GDF15	4
BP	GO:0086064	cell communication by electrical coupling involved in cardiac conduction	4/365	24/18862	0.00107872464958773	0.00301283074489978	0.00115791878074603	ATP1A1/GJA1/RYR2/CAV1	4
BP	GO:1905523	positive regulation of macrophage migration	4/365	24/18862	0.00107872464958773	0.00301283074489978	0.00115791878074603	CCL5/MAPK1/MAPK3/P2RY12	4
BP	GO:1905564	positive regulation of vascular endothelial cell proliferation	4/365	24/18862	0.00107872464958773	0.00301283074489978	0.00115791878074603	AKT3/SP1/HMGB1/GHRL	4
BP	GO:2000209	regulation of anoikis	4/365	24/18862	0.00107872464958773	0.00301283074489978	0.00115791878074603	BCL2/SRC/NOTCH1/CAV1	4
BP	GO:2001026	regulation of endothelial cell chemotaxis	4/365	24/18862	0.00107872464958773	0.00301283074489978	0.00115791878074603	HSPB1/KDR/NOTCH1/VEGFA	4
BP	GO:0032273	positive regulation of protein polymerization	9/365	132/18862	0.00108407186357315	0.00302615047143566	0.00116303794037237	OCLN/PINK1/MTOR/MECP2/HSP90AA1/ICAM1/HSPA1B/HSPA1A/CSF3	9
BP	GO:0015711	organic anion transport	17/365	376/18862	0.00111526980937806	0.00311157898842471	0.00119587061256956	HBA1/LRP2/EDN1/STXBP1/CLN3/MFSD2A/GJA1/SLC6A8/CFTR/SLC2A1/LEP/HBB/DRD4/TNFSF11/PLA2G4A/NOS2/SLC6A1	17
BP	GO:0097352	autophagosome maturation	5/365	41/18862	0.0011161203808897	0.00311229305997692	0.00119614505110631	GABARAP/MAP1LC3A/CLN3/LAMP2/ADRB2	5
BP	GO:0032649	regulation of interferon-gamma production	8/365	107/18862	0.00112427692281354	0.00313170059287178	0.00120360393238099	HRAS/IL18/CD14/IL1R1/DDIT3/HMGB1/HLA-DRB1/IL10	8
BP	GO:1903008	organelle disassembly	8/365	107/18862	0.00112427692281354	0.00313170059287178	0.00120360393238099	GABARAP/MAP1LC3A/PINK1/HTT/ATP13A2/WDR45/HUWE1/SPAST	8
BP	GO:0022404	molting cycle process	7/365	83/18862	0.00112889228658745	0.00313787691343532	0.0012059776726213	BCL2/ATP7A/EGFR/NOTCH1/FGFR2/NGFR/SHH	7
BP	GO:0022405	hair cycle process	7/365	83/18862	0.00112889228658745	0.00313787691343532	0.0012059776726213	BCL2/ATP7A/EGFR/NOTCH1/FGFR2/NGFR/SHH	7
BP	GO:0051262	protein tetramerization	7/365	83/18862	0.00112889228658745	0.00313787691343532	0.0012059776726213	TRPM1/SNCA/B2M/GRIN1/HLA-DRB1/SOD2/GRIN2B	7
BP	GO:0070509	calcium ion import	7/365	83/18862	0.00112889228658745	0.00313787691343532	0.0012059776726213	PSEN2/CTNNB1/CXCL12/CCL2/PDGFRB/TRPV4/CALCR	7
BP	GO:0070542	response to fatty acid	6/365	61/18862	0.001141663034796	0.00317000759900386	0.00121832643277686	EDN1/SRC/UCP2/TLR2/LPL/ADIPOQ	6
BP	GO:1903961	positive regulation of anion transmembrane transport	6/365	61/18862	0.001141663034796	0.00317000759900386	0.00121832643277686	OCLN/CFTR/TERT/IGF1/ADIPOQ/C3	6
BP	GO:0015748	organophosphate ester transport	9/365	133/18862	0.00114338392141133	0.00317142100936243	0.00121886964762617	ABCD1/SCARB2/MFSD2A/P2RX7/GJA1/CETP/APOE/ABCA1/FASLG	9
BP	GO:0050768	negative regulation of neurogenesis	9/365	133/18862	0.00114338392141133	0.00317142100936243	0.00121886964762617	SPP1/NF1/RTN4/SORL1/DICER1/B2M/IL6/NOTCH1/NGFR	9
BP	GO:0002708	positive regulation of lymphocyte mediated immunity	8/365	108/18862	0.00119418878438916	0.00330883223795282	0.00127168079293845	PTPRC/IL18/IL1R1/B2M/IL6/HLA-DRB1/NLRP3/C3	8
BP	GO:0008593	regulation of Notch signaling pathway	8/365	108/18862	0.00119418878438916	0.00330883223795282	0.00127168079293845	NFKBIA/EP300/CREBBP/SRC/EGFR/NOTCH1/KIT/ADAM10	8
BP	GO:1902749	regulation of cell cycle G2/M phase transition	12/365	219/18862	0.00119962587742658	0.00332213854097922	0.00127679479351835	MECP2/HSP90AA1/BRD4/DYNC1H1/RAD21/ATM/BRCA1/ALMS1/CCND1/CDKN1A/APP/AURKA	12
BP	GO:0098773	skin epidermis development	7/365	84/18862	0.00121145570389634	0.00335312488323291	0.00128870374914186	BCL2/ATP7A/EGFR/NOTCH1/FGFR2/NGFR/SHH	7
BP	GO:0008344	adult locomotory behavior	6/365	62/18862	0.00124373341788763	0.00342976855069751	0.00131816014729259	MECP2/CHD7/CXCL12/APP/DRD4/GDNF	6
BP	GO:0010573	vascular endothelial growth factor production	6/365	62/18862	0.00124373341788763	0.00342976855069751	0.00131816014729259	ATF4/RORA/GATA4/BRCA1/IL6/C3	6
BP	GO:0032613	interleukin-10 production	6/365	62/18862	0.00124373341788763	0.00342976855069751	0.00131816014729259	HMGB1/AGER/IL6/TLR2/HLA-DRB1/CD40LG	6
BP	GO:0042698	ovulation cycle	6/365	62/18862	0.00124373341788763	0.00342976855069751	0.00131816014729259	GNRH1/ETS1/SRC/EGFR/LEP/EGR1	6
BP	GO:1901016	regulation of potassium ion transmembrane transporter activity	6/365	62/18862	0.00124373341788763	0.00342976855069751	0.00131816014729259	NPPA/NEDD4L/ANK2/ANK3/CASQ2/CAV1	6
BP	GO:1902686	mitochondrial outer membrane permeabilization involved in programmed cell death	6/365	62/18862	0.00124373341788763	0.00342976855069751	0.00131816014729259	BCL2/GSK3B/BCL2L11/SPG7/HSPA1A/BAX	6
BP	GO:1903018	regulation of glycoprotein metabolic process	6/365	62/18862	0.00124373341788763	0.00342976855069751	0.00131816014729259	BCL2/CTNNB1/AGO2/ITM2B/CST3/IGF1	6
BP	GO:0014075	response to amine	5/365	42/18862	0.00124711451058479	0.00343005641008975	0.00131827078005782	ICAM1/DRD4/GRIN2A/NQO1/DBH	5
BP	GO:0031670	cellular response to nutrient	5/365	42/18862	0.00124711451058479	0.00343005641008975	0.00131827078005782	XBP1/PPARG/LEP/BGLAP/LPL	5
BP	GO:0043114	regulation of vascular permeability	5/365	42/18862	0.00124711451058479	0.00343005641008975	0.00131827078005782	OCLN/SRC/APOE/VEGFA/TRPV4	5
BP	GO:0048806	genitalia development	5/365	42/18862	0.00124711451058479	0.00343005641008975	0.00131827078005782	LRP2/CHD7/AR/BAX/SHH	5
BP	GO:1900371	regulation of purine nucleotide biosynthetic process	5/365	42/18862	0.00124711451058479	0.00343005641008975	0.00131827078005782	PARP1/PINK1/PPARA/NOS2/NOS1	5
BP	GO:0032469	endoplasmic reticulum calcium ion homeostasis	4/365	25/18862	0.00126477549987895	0.00345142594701066	0.0013264837167382	BCL2/ITPR1/BAX/APP	4
BP	GO:0033622	integrin activation	4/365	25/18862	0.00126477549987895	0.00345142594701066	0.0013264837167382	SRC/CXCL12/FN1/P2RY12	4
BP	GO:0035902	response to immobilization stress	4/365	25/18862	0.00126477549987895	0.00345142594701066	0.0013264837167382	PPARG/FOS/SOD2/CYP1A1	4
BP	GO:0050927	positive regulation of positive chemotaxis	4/365	25/18862	0.00126477549987895	0.00345142594701066	0.0013264837167382	AGER/KDR/CXCL12/VEGFA	4
BP	GO:0060259	regulation of feeding behavior	4/365	25/18862	0.00126477549987895	0.00345142594701066	0.0013264837167382	MTOR/GHRL/LEPR/CNR1	4
BP	GO:0071378	cellular response to growth hormone stimulus	4/365	25/18862	0.00126477549987895	0.00345142594701066	0.0013264837167382	GHRL/PRL/GHR/GDF15	4
BP	GO:0071514	genetic imprinting	4/365	25/18862	0.00126477549987895	0.00345142594701066	0.0013264837167382	DNMT3A/MECP2/BRCA1/KCNQ1	4
BP	GO:0072012	glomerulus vasculature development	4/365	25/18862	0.00126477549987895	0.00345142594701066	0.0013264837167382	NOTCH1/BMP4/PDGFRB/EGR1	4
BP	GO:0072202	cell differentiation involved in metanephros development	4/365	25/18862	0.00126477549987895	0.00345142594701066	0.0013264837167382	STAT1/BMP4/GDNF/ADIPOQ	4
BP	GO:0072273	metanephric nephron morphogenesis	4/365	25/18862	0.00126477549987895	0.00345142594701066	0.0013264837167382	STAT1/BMP4/PDGFRB/GDNF	4
BP	GO:1900120	regulation of receptor binding	4/365	25/18862	0.00126477549987895	0.00345142594701066	0.0013264837167382	MMP9/B2M/ADIPOQ/IL10	4
BP	GO:1901017	negative regulation of potassium ion transmembrane transporter activity	4/365	25/18862	0.00126477549987895	0.00345142594701066	0.0013264837167382	NEDD4L/ANK3/CASQ2/CAV1	4
BP	GO:1902993	positive regulation of amyloid precursor protein catabolic process	4/365	25/18862	0.00126477549987895	0.00345142594701066	0.0013264837167382	SP1/AGER/IFNG/CLU	4
BP	GO:1903798	regulation of production of miRNAs involved in gene silencing by miRNA	4/365	25/18862	0.00126477549987895	0.00345142594701066	0.0013264837167382	EGFR/IL6/BMP4/TERT	4
BP	GO:1990000	amyloid fibril formation	4/365	25/18862	0.00126477549987895	0.00345142594701066	0.0013264837167382	APOE/B2M/APP/CLU	4
BP	GO:0042471	ear morphogenesis	8/365	110/18862	0.00134439798182941	0.00366488491504955	0.00140852222767325	COL2A1/EDN1/MAPK1/MAPK3/CHD7/FGFR2/DLX5/FOXG1	8
BP	GO:0090288	negative regulation of cellular response to growth factor stimulus	8/365	110/18862	0.00134439798182941	0.00366488491504955	0.00140852222767325	LRP2/SORL1/PPARG/NOTCH1/NGFR/AGT/FBN1/XDH	8
BP	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	6/365	63/18862	0.00135263725882151	0.00368350853937139	0.00141567983000598	IKBKG/TNFRSF1A/CASP4/HSPA1B/HSPA1A/ADIPOQ	6
BP	GO:0031343	positive regulation of cell killing	6/365	63/18862	0.00135263725882151	0.00368350853937139	0.00141567983000598	PTPRC/BCL2L11/B2M/HLA-DRB1/IFNG/NOS2	6
BP	GO:0050864	regulation of B cell activation	11/365	193/18862	0.00138758933243717	0.00371902606818795	0.00142933025286229	XBP1/PTPRC/MIF/BCL2/MEF2C/ATM/CTLA4/AHR/CDKN1A/IL6/IL10	11
BP	GO:0003207	cardiac chamber formation	3/365	12/18862	0.00138856050548681	0.00371902606818795	0.00142933025286229	MEF2C/NOTCH1/BMP2	3
BP	GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis	3/365	12/18862	0.00138856050548681	0.00371902606818795	0.00142933025286229	STAT1/BMP4/GDNF	3
BP	GO:0006983	ER overload response	3/365	12/18862	0.00138856050548681	0.00371902606818795	0.00142933025286229	GSK3B/BCL2L11/DDIT3	3
BP	GO:0009886	post-embryonic animal morphogenesis	3/365	12/18862	0.00138856050548681	0.00371902606818795	0.00142933025286229	BCL2L11/BAX/FBN1	3
BP	GO:0031953	negative regulation of protein autophosphorylation	3/365	12/18862	0.00138856050548681	0.00371902606818795	0.00142933025286229	PTPRC/ADIPOQ/CAV1	3
BP	GO:0033145	positive regulation of intracellular steroid hormone receptor signaling pathway	3/365	12/18862	0.00138856050548681	0.00371902606818795	0.00142933025286229	PARP1/KMT2D/AR	3
BP	GO:0034372	very-low-density lipoprotein particle remodeling	3/365	12/18862	0.00138856050548681	0.00371902606818795	0.00142933025286229	CETP/APOE/LPL	3
BP	GO:0034392	negative regulation of smooth muscle cell apoptotic process	3/365	12/18862	0.00138856050548681	0.00371902606818795	0.00142933025286229	EDN1/DNMT1/IGF1	3
BP	GO:0035630	bone mineralization involved in bone maturation	3/365	12/18862	0.00138856050548681	0.00371902606818795	0.00142933025286229	LEP/IGF1/BMP2	3
BP	GO:0038180	nerve growth factor signaling pathway	3/365	12/18862	0.00138856050548681	0.00371902606818795	0.00142933025286229	SORT1/NGF/NTRK1	3
BP	GO:0043383	negative T cell selection	3/365	12/18862	0.00138856050548681	0.00371902606818795	0.00142933025286229	PTPRC/GLI3/SHH	3
BP	GO:0044849	estrous cycle	3/365	12/18862	0.00138856050548681	0.00371902606818795	0.00142933025286229	GNRH1/ETS1/EGR1	3
BP	GO:0045989	positive regulation of striated muscle contraction	3/365	12/18862	0.00138856050548681	0.00371902606818795	0.00142933025286229	NPPA/ATP1A1/KCNQ1	3
BP	GO:0051583	dopamine uptake involved in synaptic transmission	3/365	12/18862	0.00138856050548681	0.00371902606818795	0.00142933025286229	SNCA/DRD4/GDNF	3
BP	GO:0051934	catecholamine uptake involved in synaptic transmission	3/365	12/18862	0.00138856050548681	0.00371902606818795	0.00142933025286229	SNCA/DRD4/GDNF	3
BP	GO:0060442	branching involved in prostate gland morphogenesis	3/365	12/18862	0.00138856050548681	0.00371902606818795	0.00142933025286229	FGFR2/BMP4/SHH	3
BP	GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	3/365	12/18862	0.00138856050548681	0.00371902606818795	0.00142933025286229	EDN1/MTOR/IGF1	3
BP	GO:0061517	macrophage proliferation	3/365	12/18862	0.00138856050548681	0.00371902606818795	0.00142933025286229	MAPK1/MAPK3/CLU	3
BP	GO:0070278	extracellular matrix constituent secretion	3/365	12/18862	0.00138856050548681	0.00371902606818795	0.00142933025286229	TNFRSF1A/NOTCH1/BMP2	3
BP	GO:0071107	response to parathyroid hormone	3/365	12/18862	0.00138856050548681	0.00371902606818795	0.00142933025286229	MEF2C/HDAC4/GJA1	3
BP	GO:0071639	positive regulation of monocyte chemotactic protein-1 production	3/365	12/18862	0.00138856050548681	0.00371902606818795	0.00142933025286229	HMGB1/AGER/ADIPOQ	3
BP	GO:0071679	commissural neuron axon guidance	3/365	12/18862	0.00138856050548681	0.00371902606818795	0.00142933025286229	DAG1/GDNF/VEGFA	3
BP	GO:0150065	regulation of deacetylase activity	3/365	12/18862	0.00138856050548681	0.00371902606818795	0.00142933025286229	PINK1/LRRK2/VEGFA	3
BP	GO:1900272	negative regulation of long-term synaptic potentiation	3/365	12/18862	0.00138856050548681	0.00371902606818795	0.00142933025286229	AGER/APOE/APP	3
BP	GO:1903624	regulation of DNA catabolic process	3/365	12/18862	0.00138856050548681	0.00371902606818795	0.00142933025286229	ATM/IL6/BAX	3
BP	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA	3/365	12/18862	0.00138856050548681	0.00371902606818795	0.00142933025286229	EGFR/IL6/BMP4	3
BP	GO:0014003	oligodendrocyte development	5/365	43/18862	0.00138912800216038	0.00371902606818795	0.00142933025286229	PLP1/MED12/TLR2/CLU/SHH	5
BP	GO:0030808	regulation of nucleotide biosynthetic process	5/365	43/18862	0.00138912800216038	0.00371902606818795	0.00142933025286229	PARP1/PINK1/PPARA/NOS2/NOS1	5
BP	GO:0042220	response to cocaine	5/365	43/18862	0.00138912800216038	0.00371902606818795	0.00142933025286229	DNMT3A/MTOR/HSP90AB1/DRD4/CNR1	5
BP	GO:0046677	response to antibiotic	5/365	43/18862	0.00138912800216038	0.00371902606818795	0.00142933025286229	MEF2C/ATP7A/HSP90AA1/PLA2G4A/CYP1A1	5
BP	GO:0090311	regulation of protein deacetylation	5/365	43/18862	0.00138912800216038	0.00371902606818795	0.00142933025286229	PINK1/EP300/LRRK2/IFNG/VEGFA	5
BP	GO:2000142	regulation of DNA-templated transcription, initiation	5/365	43/18862	0.00138912800216038	0.00371902606818795	0.00142933025286229	CTNNB1/MED12/SETX/HMGB1/JUN	5
BP	GO:0070507	regulation of microtubule cytoskeleton organization	9/365	137/18862	0.00140743102905612	0.0037661012301021	0.00144742261141225	OCLN/MECP2/GSK3B/DYNC1H1/SNCA/SPAST/HSPA1B/HSPA1A/TRPV4	9
BP	GO:0051648	vesicle localization	12/365	224/18862	0.00145396295545632	0.00388862652471045	0.00149451265786893	IKBKG/PINK1/HTT/TRAPPC9/CLN3/DYNC1H1/PIK3CG/SERPINA1/LRRK2/SLC2A4/CDH2/GRIA1	12
BP	GO:0002562	somatic diversification of immune receptors via germline recombination within a single locus	6/365	64/18862	0.00146867036594727	0.00389348546480865	0.00149638009035041	PTPRC/PRKDC/ATM/HMGB1/CD40LG/IL10	6
BP	GO:0003281	ventricular septum development	6/365	64/18862	0.00146867036594727	0.00389348546480865	0.00149638009035041	LRP2/MATR3/GATA4/NOTCH1/FGFR2/BMP4	6
BP	GO:0016444	somatic cell DNA recombination	6/365	64/18862	0.00146867036594727	0.00389348546480865	0.00149638009035041	PTPRC/PRKDC/ATM/HMGB1/CD40LG/IL10	6
BP	GO:0035794	positive regulation of mitochondrial membrane permeability	6/365	64/18862	0.00146867036594727	0.00389348546480865	0.00149638009035041	BCL2/GSK3B/BCL2L11/SPG7/HSPA1A/BAX	6
BP	GO:0060411	cardiac septum morphogenesis	6/365	64/18862	0.00146867036594727	0.00389348546480865	0.00149638009035041	LRP2/GATA4/CHD7/NOTCH1/FGFR2/BMP4	6
BP	GO:0072089	stem cell proliferation	6/365	64/18862	0.00146867036594727	0.00389348546480865	0.00149638009035041	PTPRC/EIF2AK2/GJA1/KITLG/EPCAM/TERT	6
BP	GO:0002026	regulation of the force of heart contraction	4/365	26/18862	0.00147214515377461	0.00389348546480865	0.00149638009035041	ATP1A1/RYR2/CAV1/NOS1	4
BP	GO:0010460	positive regulation of heart rate	4/365	26/18862	0.00147214515377461	0.00389348546480865	0.00149638009035041	NPPA/EDN1/KCNQ1/RYR2	4
BP	GO:0021772	olfactory bulb development	4/365	26/18862	0.00147214515377461	0.00389348546480865	0.00149638009035041	CHD7/LRRK2/DLX5/ERBB4	4
BP	GO:0036475	neuron death in response to oxidative stress	4/365	26/18862	0.00147214515377461	0.00389348546480865	0.00149638009035041	PARP1/PINK1/ATF4/IL10	4
BP	GO:0042104	positive regulation of activated T cell proliferation	4/365	26/18862	0.00147214515377461	0.00389348546480865	0.00149638009035041	IL18/HMGB1/AGER/IGF1	4
BP	GO:0042634	regulation of hair cycle	4/365	26/18862	0.00147214515377461	0.00389348546480865	0.00149638009035041	ARNTL/CLOCK/NGFR/TERT	4
BP	GO:0046639	negative regulation of alpha-beta T cell differentiation	4/365	26/18862	0.00147214515377461	0.00389348546480865	0.00149638009035041	GLI3/HMGB1/SOCS1/SHH	4
BP	GO:0048873	homeostasis of number of cells within a tissue	4/365	26/18862	0.00147214515377461	0.00389348546480865	0.00149638009035041	BCL2/AKT3/NOTCH1/BAX	4
BP	GO:0050926	regulation of positive chemotaxis	4/365	26/18862	0.00147214515377461	0.00389348546480865	0.00149638009035041	AGER/KDR/CXCL12/VEGFA	4
BP	GO:0051953	negative regulation of amine transport	4/365	26/18862	0.00147214515377461	0.00389348546480865	0.00149638009035041	SNCA/LEP/CNR1/P2RY12	4
BP	GO:0061437	renal system vasculature development	4/365	26/18862	0.00147214515377461	0.00389348546480865	0.00149638009035041	NOTCH1/BMP4/PDGFRB/EGR1	4
BP	GO:0061440	kidney vasculature development	4/365	26/18862	0.00147214515377461	0.00389348546480865	0.00149638009035041	NOTCH1/BMP4/PDGFRB/EGR1	4
BP	GO:0070920	regulation of production of small RNA involved in gene silencing by RNA	4/365	26/18862	0.00147214515377461	0.00389348546480865	0.00149638009035041	EGFR/IL6/BMP4/TERT	4
BP	GO:0099625	ventricular cardiac muscle cell membrane repolarization	4/365	26/18862	0.00147214515377461	0.00389348546480865	0.00149638009035041	ANK2/KCNQ1/KCNH2/SCN5A	4
BP	GO:1903205	regulation of hydrogen peroxide-induced cell death	4/365	26/18862	0.00147214515377461	0.00389348546480865	0.00149638009035041	PINK1/TXN/LRRK2/IL10	4
BP	GO:2000311	regulation of AMPA receptor activity	4/365	26/18862	0.00147214515377461	0.00389348546480865	0.00149638009035041	MEF2C/ADRB2/NLGN3/RELN	4
BP	GO:0032609	interferon-gamma production	8/365	112/18862	0.00150925525478621	0.00398961717351062	0.00153332631148137	HRAS/IL18/CD14/IL1R1/DDIT3/HMGB1/HLA-DRB1/IL10	8
BP	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	5/365	44/18862	0.00154271168635671	0.0040718875271765	0.00156494520934664	BCL2/PARP1/PINK1/HSPB1/SOD2	5
BP	GO:0010863	positive regulation of phospholipase C activity	5/365	44/18862	0.00154271168635671	0.0040718875271765	0.00156494520934664	HRAS/EGFR/KIT/PDGFRB/P2RY12	5
BP	GO:0060976	coronary vasculature development	5/365	44/18862	0.00154271168635671	0.0040718875271765	0.00156494520934664	LRP2/NOTCH1/BMP4/PDGFRB/VEGFA	5
BP	GO:0002433	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis	9/365	139/18862	0.00155672775063128	0.00410267525015312	0.00157677782978553	PIK3R2/FCGR3A/PTPRC/HSP90AA1/HSP90AB1/MAPK1/MAPK3/SRC/PLA2G6	9
BP	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	9/365	139/18862	0.00155672775063128	0.00410267525015312	0.00157677782978553	PIK3R2/FCGR3A/PTPRC/HSP90AA1/HSP90AB1/MAPK1/MAPK3/SRC/PLA2G6	9
BP	GO:0055076	transition metal ion homeostasis	9/365	139/18862	0.00155672775063128	0.00410267525015312	0.00157677782978553	ATP7A/ATP13A2/XIAP/TF/B2M/CP/APP/IFNG/MYC	9
BP	GO:0006094	gluconeogenesis	7/365	88/18862	0.00159007497958752	0.00418845115408208	0.00160974401292176	EP300/ATF4/PPARA/ATF3/LEP/LEPR/ADIPOQ	7
BP	GO:0048814	regulation of dendrite morphogenesis	6/365	65/18862	0.00159213301847131	0.00418965521301098	0.001610206767907	NEDD4L/GSK3B/CUX1/CDKL5/IL1RAPL1/RELN	6
BP	GO:0070265	necrotic cell death	6/365	65/18862	0.00159213301847131	0.00418965521301098	0.001610206767907	NUPR1/CD14/FAS/FASLG/BAX/CAV1	6
BP	GO:0001909	leukocyte mediated cytotoxicity	8/365	113/18862	0.00159748487032143	0.00420162603581024	0.00161480750446139	PTPRC/ICAM1/IL18/AGER/LEP/B2M/HLA-DRB1/NOS2	8
BP	GO:0032886	regulation of microtubule-based process	12/365	227/18862	0.00162686077994212	0.00427673999106834	0.00164367598956853	OCLN/MECP2/GSK3B/DYNC1H1/SNCA/BRCA1/ALMS1/SPAST/HSPA1B/HSPA1A/AURKA/TRPV4	12
BP	GO:0016052	carbohydrate catabolic process	11/365	197/18862	0.001634188029006	0.00429384545372358	0.00165025011806725	NUPR1/EP300/SCARB2/MAN2B1/P2RX7/HDAC4/PPARA/HMGB1/APP/IFNG/IGF1	11
BP	GO:0038094	Fc-gamma receptor signaling pathway	9/365	140/18862	0.00163600287195047	0.00429645711579969	0.001651253856021	PIK3R2/FCGR3A/PTPRC/HSP90AA1/HSP90AB1/MAPK1/MAPK3/SRC/PLA2G6	9
BP	GO:0072521	purine-containing compound metabolic process	19/365	460/18862	0.00167550944716443	0.00439800222991906	0.00169028060683694	NPPA/ABCD1/NUPR1/PARP1/PINK1/EP300/RORA/P2RX7/HDAC4/PPARA/LRRK2/APP/ACSL4/IFNG/IGF1/TTR/NOS2/XDH/NOS1	19
BP	GO:0006096	glycolytic process	8/365	114/18862	0.0016897500462495	0.004430937746528	0.00170293868704925	NUPR1/EP300/P2RX7/HDAC4/PPARA/APP/IFNG/IGF1	8
BP	GO:0010633	negative regulation of epithelial cell migration	8/365	114/18862	0.0016897500462495	0.004430937746528	0.00170293868704925	KLF4/MEF2C/MECP2/GADD45A/PPARG/HMGB1/APOE/NOTCH1	8
BP	GO:0097581	lamellipodium organization	7/365	89/18862	0.00169773951127692	0.00443215720117459	0.00170340735905811	OCLN/ATP7A/MTOR/HDAC4/SRC/KIT/P2RY12	7
BP	GO:0003401	axis elongation	4/365	27/18862	0.00170207030461615	0.00443215720117459	0.00170340735905811	MED12/FGFR2/BMP4/SHH	4
BP	GO:0010758	regulation of macrophage chemotaxis	4/365	27/18862	0.00170207030461615	0.00443215720117459	0.00170340735905811	CCL5/MIF/MAPK1/MAPK3	4
BP	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	4/365	27/18862	0.00170207030461615	0.00443215720117459	0.00170340735905811	HDAC4/ANK2/RYR2/CASQ2	4
BP	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	4/365	27/18862	0.00170207030461615	0.00443215720117459	0.00170340735905811	MECP2/BRD4/CCND1/APP	4
BP	GO:0033688	regulation of osteoblast proliferation	4/365	27/18862	0.00170207030461615	0.00443215720117459	0.00170340735905811	BCL2/EIF2AK2/FGFR2/BMP2	4
BP	GO:0034110	regulation of homotypic cell-cell adhesion	4/365	27/18862	0.00170207030461615	0.00443215720117459	0.00170340735905811	CCL5/PRKCA/ANK3/TNFSF11	4
BP	GO:0034123	positive regulation of toll-like receptor signaling pathway	4/365	27/18862	0.00170207030461615	0.00443215720117459	0.00170340735905811	RTN4/HMGB1/TLR2/CAV1	4
BP	GO:0035116	embryonic hindlimb morphogenesis	4/365	27/18862	0.00170207030461615	0.00443215720117459	0.00170340735905811	CHD7/NOTCH1/BMP4/SHH	4
BP	GO:0045987	positive regulation of smooth muscle contraction	4/365	27/18862	0.00170207030461615	0.00443215720117459	0.00170340735905811	EDN1/KIT/GHRL/CHRM3	4
BP	GO:0060441	epithelial tube branching involved in lung morphogenesis	4/365	27/18862	0.00170207030461615	0.00443215720117459	0.00170340735905811	DAG1/FGFR2/BMP4/SHH	4
BP	GO:0090025	regulation of monocyte chemotaxis	4/365	27/18862	0.00170207030461615	0.00443215720117459	0.00170340735905811	CCL5/HMGB1/CXCL12/SERPINE1	4
BP	GO:0090200	positive regulation of release of cytochrome c from mitochondria	4/365	27/18862	0.00170207030461615	0.00443215720117459	0.00170340735905811	MMP9/PINK1/BCL2L11/BAX	4
BP	GO:1902883	negative regulation of response to oxidative stress	4/365	27/18862	0.00170207030461615	0.00443215720117459	0.00170340735905811	PINK1/TXN/LRRK2/IL10	4
BP	GO:0010828	positive regulation of glucose transmembrane transport	5/365	45/18862	0.00170842177282633	0.00444206634822305	0.00170721573345419	OCLN/TERT/IGF1/ADIPOQ/C3	5
BP	GO:0032570	response to progesterone	5/365	45/18862	0.00170842177282633	0.00444206634822305	0.00170721573345419	SRC/FOS/TXNIP/TLR2/CAV1	5
BP	GO:0032881	regulation of polysaccharide metabolic process	5/365	45/18862	0.00170842177282633	0.00444206634822305	0.00170721573345419	MTOR/GSK3B/HMGB1/IGF1/POMC	5
BP	GO:0030193	regulation of blood coagulation	6/365	66/18862	0.00172332973884379	0.00447194241601805	0.00171869797820133	EDN1/PLAT/APOE/SERPINE1/CAV1/PROC	6
BP	GO:0045600	positive regulation of fat cell differentiation	6/365	66/18862	0.00172332973884379	0.00447194241601805	0.00171869797820133	XBP1/CEBPB/PPARG/LPL/HTR2C/BMP2	6
BP	GO:1900076	regulation of cellular response to insulin stimulus	6/365	66/18862	0.00172332973884379	0.00447194241601805	0.00171869797820133	SORL1/SRC/LEP/BGLAP/LPL/SOCS1	6
BP	GO:1902108	regulation of mitochondrial membrane permeability involved in apoptotic process	6/365	66/18862	0.00172332973884379	0.00447194241601805	0.00171869797820133	BCL2/GSK3B/BCL2L11/HSPA1A/BAX/CAMK2A	6
BP	GO:0003222	ventricular trabecula myocardium morphogenesis	3/365	13/18862	0.00177936246935456	0.00458551608301418	0.00176234765292522	CHD7/NRG1/NOTCH1	3
BP	GO:0007567	parturition	3/365	13/18862	0.00177936246935456	0.00458551608301418	0.00176234765292522	EDN1/CYP1A1/CRHR1	3
BP	GO:0016264	gap junction assembly	3/365	13/18862	0.00177936246935456	0.00458551608301418	0.00176234765292522	GJA1/AGT/CAV1	3
BP	GO:0031650	regulation of heat generation	3/365	13/18862	0.00177936246935456	0.00458551608301418	0.00176234765292522	EDNRB/TNFSF11/CNR1	3
BP	GO:0033605	positive regulation of catecholamine secretion	3/365	13/18862	0.00177936246935456	0.00458551608301418	0.00176234765292522	PINK1/CXCL12/GDNF	3
BP	GO:0034616	response to laminar fluid shear stress	3/365	13/18862	0.00177936246935456	0.00458551608301418	0.00176234765292522	KLF4/ETS1/ABCA1	3
BP	GO:0050667	homocysteine metabolic process	3/365	13/18862	0.00177936246935456	0.00458551608301418	0.00176234765292522	CBS/MTHFR/NOX4	3
BP	GO:0061043	regulation of vascular wound healing	3/365	13/18862	0.00177936246935456	0.00458551608301418	0.00176234765292522	XBP1/CXCR4/SERPINE1	3
BP	GO:0070424	regulation of nucleotide-binding oligomerization domain containing signaling pathway	3/365	13/18862	0.00177936246935456	0.00458551608301418	0.00176234765292522	XIAP/HSPA1B/HSPA1A	3
BP	GO:0071236	cellular response to antibiotic	3/365	13/18862	0.00177936246935456	0.00458551608301418	0.00176234765292522	MEF2C/ATP7A/PLA2G4A	3
BP	GO:0071635	negative regulation of transforming growth factor beta production	3/365	13/18862	0.00177936246935456	0.00458551608301418	0.00176234765292522	HSP90AB1/FURIN/FN1	3
BP	GO:1903054	negative regulation of extracellular matrix organization	3/365	13/18862	0.00177936246935456	0.00458551608301418	0.00176234765292522	TNFRSF1A/CST3/NOTCH1	3
BP	GO:2001140	positive regulation of phospholipid transport	3/365	13/18862	0.00177936246935456	0.00458551608301418	0.00176234765292522	CETP/APOE/FASLG	3
BP	GO:2001198	regulation of dendritic cell differentiation	3/365	13/18862	0.00177936246935456	0.00458551608301418	0.00176234765292522	CEBPB/HMGB1/AGER	3
BP	GO:0001704	formation of primary germ layer	8/365	115/18862	0.00178617940691711	0.00459855534471429	0.00176735902173019	MMP9/KLF4/GJA1/SOX2/FGFR2/BMP4/MMP2/FN1	8
BP	GO:0006757	ATP generation from ADP	8/365	115/18862	0.00178617940691711	0.00459855534471429	0.00176735902173019	NUPR1/EP300/P2RX7/HDAC4/PPARA/APP/IFNG/IGF1	8
BP	GO:0044344	cellular response to fibroblast growth factor stimulus	9/365	142/18862	0.00180426310968681	0.00463826773875284	0.00178262165371291	CCL5/HNRNPA1/SETX/MAPK1/MAPK3/FGFR2/NGFR/CCL2/NR4A1	9
BP	GO:0072655	establishment of protein localization to mitochondrion	9/365	142/18862	0.00180426310968681	0.00463826773875284	0.00178262165371291	BCL2/PINK1/BCS1L/HSP90AA1/HUWE1/BCL2L11/DDIT3/LRRK2/BAX	9
BP	GO:0097549	chromatin organization involved in negative regulation of transcription	9/365	142/18862	0.00180426310968681	0.00463826773875284	0.00178262165371291	DNMT3A/MECP2/PHF8/KMT2D/DNMT1/HMGB1/MTHFR/TET1/CDKN2A	9
BP	GO:0048704	embryonic skeletal system morphogenesis	7/365	90/18862	0.00181098544397336	0.004648699271092	0.00178663079602132	COL2A1/CTNNB1/GLI3/MED12/FGFR2/BMP4/SATB2	7
BP	GO:0060349	bone morphogenesis	7/365	90/18862	0.00181098544397336	0.004648699271092	0.00178663079602132	COL2A1/MEF2C/GLI3/FGFR2/DLX5/BMP4/TRPV4	7
BP	GO:1903035	negative regulation of response to wounding	7/365	90/18862	0.00181098544397336	0.004648699271092	0.00178663079602132	SPP1/EDN1/PLAT/GJA1/APOE/SERPINE1/PROC	7
BP	GO:0002637	regulation of immunoglobulin production	6/365	67/18862	0.00186256906043951	0.00477175059341183	0.00183392301027895	XBP1/PTPRC/PRKDC/IL6/CD40LG/IL10	6
BP	GO:0034394	protein localization to cell surface	6/365	67/18862	0.00186256906043951	0.00477175059341183	0.00183392301027895	NEDD4L/CTNNB1/HSP90AB1/ANK2/ASTN2/ERBB4	6
BP	GO:0050766	positive regulation of phagocytosis	6/365	67/18862	0.00186256906043951	0.00477175059341183	0.00183392301027895	PTPRC/PPARG/C4A/CCL2/IFNG/C3	6
BP	GO:1900046	regulation of hemostasis	6/365	67/18862	0.00186256906043951	0.00477175059341183	0.00183392301027895	EDN1/PLAT/APOE/SERPINE1/CAV1/PROC	6
BP	GO:0035725	sodium ion transmembrane transport	10/365	171/18862	0.00187119652591446	0.00478916509370967	0.00184061591096257	NEDD4L/ATP1A1/SLC9A6/SLC6A8/ANK3/DRD4/SCN5A/SLC6A1/NOS1/SLC6A4	10
BP	GO:0051302	regulation of cell division	10/365	171/18862	0.00187119652591446	0.00478916509370967	0.00184061591096257	ZFYVE26/SPAST/BRCA2/FGFR2/THBS4/TXNIP/MYC/AURKA/VEGFA/SHH	10
BP	GO:0008038	neuron recognition	5/365	46/18862	0.00188681909383814	0.00481972237049723	0.00185235996420574	RTN4/CXCR4/APP/CNR1/FOXG1	5
BP	GO:0010823	negative regulation of mitochondrion organization	5/365	46/18862	0.00188681909383814	0.00481972237049723	0.00185235996420574	PINK1/HUWE1/HSPA1A/IGF1/CLU	5
BP	GO:0070849	response to epidermal growth factor	5/365	46/18862	0.00188681909383814	0.00481972237049723	0.00185235996420574	EEF1A1/MAPK1/MAPK3/EGFR/ERBB4	5
BP	GO:1900274	regulation of phospholipase C activity	5/365	46/18862	0.00188681909383814	0.00481972237049723	0.00185235996420574	HRAS/EGFR/KIT/PDGFRB/P2RY12	5
BP	GO:0019319	hexose biosynthetic process	7/365	91/18862	0.00193000639870109	0.00492043521227545	0.00189106684847221	EP300/ATF4/PPARA/ATF3/LEP/LEPR/ADIPOQ	7
BP	GO:0050810	regulation of steroid biosynthetic process	7/365	91/18862	0.00193000639870109	0.00492043521227545	0.00189106684847221	ATP1A1/SP1/LEP/APOE/IFNG/EGR1/BMP2	7
BP	GO:1901992	positive regulation of mitotic cell cycle phase transition	7/365	91/18862	0.00193000639870109	0.00492043521227545	0.00189106684847221	MECP2/BRD4/EGFR/CCND1/APP/TERT/CYP1A1	7
BP	GO:2001251	negative regulation of chromosome organization	7/365	91/18862	0.00193000639870109	0.00492043521227545	0.00189106684847221	PARP1/HNRNPA1/PHF8/RAD21/ATM/SRC/TET1	7
BP	GO:0001782	B cell homeostasis	4/365	28/18862	0.00195577839546974	0.00496197000576278	0.00190702988174742	BCL2/MEF2C/BCL2L11/BAX	4
BP	GO:0001958	endochondral ossification	4/365	28/18862	0.00195577839546974	0.00496197000576278	0.00190702988174742	COL2A1/MEF2C/DLX5/BMP4	4
BP	GO:0014044	Schwann cell development	4/365	28/18862	0.00195577839546974	0.00496197000576278	0.00190702988174742	DAG1/NF1/MED12/DICER1	4
BP	GO:0021988	olfactory lobe development	4/365	28/18862	0.00195577839546974	0.00496197000576278	0.00190702988174742	CHD7/LRRK2/DLX5/ERBB4	4
BP	GO:0036075	replacement ossification	4/365	28/18862	0.00195577839546974	0.00496197000576278	0.00190702988174742	COL2A1/MEF2C/DLX5/BMP4	4
BP	GO:0044331	cell-cell adhesion mediated by cadherin	4/365	28/18862	0.00195577839546974	0.00496197000576278	0.00190702988174742	NOTCH1/EPCAM/CDH2/VEGFA	4
BP	GO:0051569	regulation of histone H3-K4 methylation	4/365	28/18862	0.00195577839546974	0.00496197000576278	0.00190702988174742	CTNNB1/KMT2A/DNMT1/BRCA1	4
BP	GO:0086011	membrane repolarization during action potential	4/365	28/18862	0.00195577839546974	0.00496197000576278	0.00190702988174742	ATP1A1/KCNQ1/CAV1/KCNH2	4
BP	GO:0090344	negative regulation of cell aging	4/365	28/18862	0.00195577839546974	0.00496197000576278	0.00190702988174742	MIF/AKT3/PRKDC/TERT	4
BP	GO:1902175	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	4/365	28/18862	0.00195577839546974	0.00496197000576278	0.00190702988174742	PARP1/PINK1/HSPB1/SOD2	4
BP	GO:1990778	protein localization to cell periphery	15/365	329/18862	0.00197907040991745	0.00501863106856004	0.00192880638175859	STXBP1/HRAS/DAG1/CLN3/TNFRSF1A/ANK2/EGFR/AR/ANK3/IFNG/CDH2/ADIPOQ/ADAM10/CAV1/GRIN2A	15
BP	GO:0008277	regulation of G protein-coupled receptor signaling pathway	9/365	144/18862	0.00198609466104129	0.00503400457912354	0.00193471487052372	CCL5/EDN1/SNCA/UBQLN2/ADRB2/PRKCA/CAMK2A/CALCR/C3	9
BP	GO:0048706	embryonic skeletal system development	8/365	117/18862	0.00199205470930523	0.00504666715803659	0.00193958146914062	COL2A1/CTNNB1/GLI3/MED12/FGFR2/BMP4/SATB2/SHH	8
BP	GO:0006111	regulation of gluconeogenesis	5/365	47/18862	0.00207846835384395	0.00525287463255396	0.0020188330194901	EP300/PPARA/LEP/LEPR/ADIPOQ	5
BP	GO:0010712	regulation of collagen metabolic process	5/365	47/18862	0.00207846835384395	0.00525287463255396	0.0020188330194901	PPARG/CST3/IL6/BMP4/PDGFRB	5
BP	GO:0031952	regulation of protein autophosphorylation	5/365	47/18862	0.00207846835384395	0.00525287463255396	0.0020188330194901	PTPRC/SRC/ADIPOQ/VEGFA/CAV1	5
BP	GO:0099054	presynapse assembly	5/365	47/18862	0.00207846835384395	0.00525287463255396	0.0020188330194901	CEL/SNCA/NLGN3/APP/IL1RAPL1	5
BP	GO:0120163	negative regulation of cold-induced thermogenesis	5/365	47/18862	0.00207846835384395	0.00525287463255396	0.0020188330194901	ARNTL/ATF4/DDIT3/NOTCH1/ADIPOQ	5
BP	GO:0002431	Fc receptor mediated stimulatory signaling pathway	9/365	145/18862	0.00208233897661046	0.00526011689361928	0.00202161643177331	PIK3R2/FCGR3A/PTPRC/HSP90AA1/HSP90AB1/MAPK1/MAPK3/SRC/PLA2G6	9
BP	GO:0034249	negative regulation of cellular amide metabolic process	12/365	234/18862	0.00209685243652549	0.0052942236626987	0.00203472465849149	EIF2AK2/AGO1/PURA/AGO2/ATF4/TARDBP/RTN4/SORL1/EIF4E/APOE/IGF1/CLU	12
BP	GO:0007052	mitotic spindle organization	8/365	118/18862	0.00210176731768807	0.00530407432053006	0.0020385105537745	SMC1A/MECP2/DYNC1H1/WDR62/SPAST/HSPA1B/HSPA1A/AURKA	8
BP	GO:1905710	positive regulation of membrane permeability	6/365	69/18862	0.00216642827213886	0.00546461955487942	0.00210021277263532	BCL2/GSK3B/BCL2L11/SPG7/HSPA1A/BAX	6
BP	GO:0070585	protein localization to mitochondrion	9/365	146/18862	0.00218226592242303	0.00550191707030932	0.00211454729629369	BCL2/PINK1/BCS1L/HSP90AA1/HUWE1/BCL2L11/DDIT3/LRRK2/BAX	9
BP	GO:0002367	cytokine production involved in immune response	7/365	93/18862	0.00218616096130467	0.00550908352020638	0.00211730157213249	IL18/IL1R1/B2M/IL6/KIT/NLRP3/IL10	7
BP	GO:0010872	regulation of cholesterol esterification	3/365	14/18862	0.00223234925321241	0.00556276289108583	0.00213793212092292	AGTR1/APOE/AGT	3
BP	GO:0010889	regulation of sequestering of triglyceride	3/365	14/18862	0.00223234925321241	0.00556276289108583	0.00213793212092292	PPARA/PPARG/LPL	3
BP	GO:0034370	triglyceride-rich lipoprotein particle remodeling	3/365	14/18862	0.00223234925321241	0.00556276289108583	0.00213793212092292	CETP/APOE/LPL	3
BP	GO:0036295	cellular response to increased oxygen levels	3/365	14/18862	0.00223234925321241	0.00556276289108583	0.00213793212092292	PPARG/FAS/CAV1	3
BP	GO:0043922	negative regulation by host of viral transcription	3/365	14/18862	0.00223234925321241	0.00556276289108583	0.00213793212092292	CCL5/TARDBP/JUN	3
BP	GO:0045820	negative regulation of glycolytic process	3/365	14/18862	0.00223234925321241	0.00556276289108583	0.00213793212092292	NUPR1/HDAC4/PPARA	3
BP	GO:0050930	induction of positive chemotaxis	3/365	14/18862	0.00223234925321241	0.00556276289108583	0.00213793212092292	AGER/CXCL12/VEGFA	3
BP	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	3/365	14/18862	0.00223234925321241	0.00556276289108583	0.00213793212092292	CXCR4/CXCL12/NTRK1	3
BP	GO:0051775	response to redox state	3/365	14/18862	0.00223234925321241	0.00556276289108583	0.00213793212092292	ARNTL/CLOCK/RYR2	3
BP	GO:0060081	membrane hyperpolarization	3/365	14/18862	0.00223234925321241	0.00556276289108583	0.00213793212092292	ATP1A1/CFTR/SOD2	3
BP	GO:0072498	embryonic skeletal joint development	3/365	14/18862	0.00223234925321241	0.00556276289108583	0.00213793212092292	COL2A1/CTNNB1/BMP4	3
BP	GO:1901722	regulation of cell proliferation involved in kidney development	3/365	14/18862	0.00223234925321241	0.00556276289108583	0.00213793212092292	BMP4/MYC/EGR1	3
BP	GO:1902894	negative regulation of pri-miRNA transcription by RNA polymerase II	3/365	14/18862	0.00223234925321241	0.00556276289108583	0.00213793212092292	HDAC4/PPARA/BMP4	3
BP	GO:1903025	regulation of RNA polymerase II regulatory region sequence-specific DNA binding	3/365	14/18862	0.00223234925321241	0.00556276289108583	0.00213793212092292	NSD1/EP300/DDIT3	3
BP	GO:2001138	regulation of phospholipid transport	3/365	14/18862	0.00223234925321241	0.00556276289108583	0.00213793212092292	CETP/APOE/FASLG	3
BP	GO:0010592	positive regulation of lamellipodium assembly	4/365	29/18862	0.00223448496390019	0.00556276289108583	0.00213793212092292	OCLN/ATP7A/MTOR/HDAC4	4
BP	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	4/365	29/18862	0.00223448496390019	0.00556276289108583	0.00213793212092292	ANK2/CHD7/RYR2/CASQ2	4
BP	GO:0014072	response to isoquinoline alkaloid	4/365	29/18862	0.00223448496390019	0.00556276289108583	0.00213793212092292	MAP1LC3A/MTOR/CXCR4/CNR1	4
BP	GO:0021799	cerebral cortex radially oriented cell migration	4/365	29/18862	0.00223448496390019	0.00556276289108583	0.00213793212092292	GLI3/RTN4/P2RY12/FOXG1	4
BP	GO:0031116	positive regulation of microtubule polymerization	4/365	29/18862	0.00223448496390019	0.00556276289108583	0.00213793212092292	OCLN/MECP2/HSPA1B/HSPA1A	4
BP	GO:0043278	response to morphine	4/365	29/18862	0.00223448496390019	0.00556276289108583	0.00213793212092292	MAP1LC3A/MTOR/CXCR4/CNR1	4
BP	GO:0045940	positive regulation of steroid metabolic process	4/365	29/18862	0.00223448496390019	0.00556276289108583	0.00213793212092292	AGTR1/APOE/IFNG/AGT	4
BP	GO:0061311	cell surface receptor signaling pathway involved in heart development	4/365	29/18862	0.00223448496390019	0.00556276289108583	0.00213793212092292	CTNNB1/NOTCH1/BMP4/BMP2	4
BP	GO:1900027	regulation of ruffle assembly	4/365	29/18862	0.00223448496390019	0.00556276289108583	0.00213793212092292	HRAS/ICAM1/CAV1/P2RY12	4
BP	GO:2000637	positive regulation of gene silencing by miRNA	4/365	29/18862	0.00223448496390019	0.00556276289108583	0.00213793212092292	AGO2/EGFR/IL6/BMP4	4
BP	GO:0040029	regulation of gene expression, epigenetic	11/365	205/18862	0.00223509559800411	0.00556276289108583	0.00213793212092292	DNMT3A/EP300/MECP2/ARID1B/KMT2D/HDAC4/DNMT1/BRCA1/HMGB1/MTHFR/KCNQ1	11
BP	GO:0010656	negative regulation of muscle cell apoptotic process	5/365	48/18862	0.00228393738633305	0.00566277985791909	0.00217637156013985	EDN1/NUPR1/GATA4/DNMT1/IGF1	5
BP	GO:0030195	negative regulation of blood coagulation	5/365	48/18862	0.00228393738633305	0.00566277985791909	0.00217637156013985	EDN1/PLAT/APOE/SERPINE1/PROC	5
BP	GO:0038084	vascular endothelial growth factor signaling pathway	5/365	48/18862	0.00228393738633305	0.00566277985791909	0.00217637156013985	HSPB1/KDR/PDGFRB/VEGFA/XDH	5
BP	GO:0042149	cellular response to glucose starvation	5/365	48/18862	0.00228393738633305	0.00566277985791909	0.00217637156013985	XBP1/BCL2/ATF4/HNRNPA1/SLC2A1	5
BP	GO:0044088	regulation of vacuole organization	5/365	48/18862	0.00228393738633305	0.00566277985791909	0.00217637156013985	NUPR1/PINK1/SCARB2/UBQLN2/LRRK2	5
BP	GO:0045778	positive regulation of ossification	5/365	48/18862	0.00228393738633305	0.00566277985791909	0.00217637156013985	MEF2C/P2RX7/ADRB2/BMP4/BMP2	5
BP	GO:0070839	metal ion export	5/365	48/18862	0.00228393738633305	0.00566277985791909	0.00217637156013985	NPPA/ATP1A1/ATP7A/KCNQ1/KCNH2	5
BP	GO:2000191	regulation of fatty acid transport	5/365	48/18862	0.00228393738633305	0.00566277985791909	0.00217637156013985	EDN1/STXBP1/PPARA/TNFSF11/PLA2G4A	5
BP	GO:2000027	regulation of animal organ morphogenesis	10/365	176/18862	0.00231197614843619	0.00572958482997871	0.00220204666051713	EDN1/MED12/AR/BMP4/NGFR/AGT/GDNF/VEGFA/BMP2/SHH	10
BP	GO:0015914	phospholipid transport	7/365	94/18862	0.00232369463669324	0.00575590048672619	0.00221216053539283	SCARB2/MFSD2A/P2RX7/CETP/APOE/ABCA1/FASLG	7
BP	GO:0002218	activation of innate immune response	9/365	148/18862	0.00239356626836051	0.00592056987173862	0.00227544778571134	MATR3/IKBKG/HRAS/EP300/PRKDC/HSP90AA1/CREBBP/SRC/HMGB1	9
BP	GO:0071774	response to fibroblast growth factor	9/365	148/18862	0.00239356626836051	0.00592056987173862	0.00227544778571134	CCL5/HNRNPA1/SETX/MAPK1/MAPK3/FGFR2/NGFR/CCL2/NR4A1	9
BP	GO:0097530	granulocyte migration	9/365	148/18862	0.00239356626836051	0.00592056987173862	0.00227544778571134	CCL5/EDN1/MAPK1/MAPK3/PIK3CG/IL1R1/PPIB/CCL2/THBS4	9
BP	GO:0006163	purine nucleotide metabolic process	18/365	441/18862	0.00249758892714783	0.00617495533523465	0.00237321554323621	NPPA/ABCD1/NUPR1/PARP1/PINK1/EP300/RORA/P2RX7/HDAC4/PPARA/LRRK2/APP/ACSL4/IFNG/IGF1/NOS2/XDH/NOS1	18
BP	GO:0045661	regulation of myoblast differentiation	5/365	49/18862	0.00250379641929035	0.00617885671164213	0.00237471495604612	MEF2C/IL18/DDIT3/NOTCH1/BMP4	5
BP	GO:0071622	regulation of granulocyte chemotaxis	5/365	49/18862	0.00250379641929035	0.00617885671164213	0.00237471495604612	CCL5/EDN1/MAPK1/MAPK3/THBS4	5
BP	GO:1900047	negative regulation of hemostasis	5/365	49/18862	0.00250379641929035	0.00617885671164213	0.00237471495604612	EDN1/PLAT/APOE/SERPINE1/PROC	5
BP	GO:0021536	diencephalon development	6/365	71/18862	0.00250625005709137	0.00617885671164213	0.00237471495604612	ETS1/SOX2/BMP4/BAX/BMP2/SHH	6
BP	GO:0032720	negative regulation of tumor necrosis factor production	6/365	71/18862	0.00250625005709137	0.00617885671164213	0.00237471495604612	DICER1/GHRL/IGF1/ADIPOQ/POMC/IL10	6
BP	GO:0050818	regulation of coagulation	6/365	71/18862	0.00250625005709137	0.00617885671164213	0.00237471495604612	EDN1/PLAT/APOE/SERPINE1/CAV1/PROC	6
BP	GO:0001975	response to amphetamine	4/365	30/18862	0.00253939117237502	0.00622537395607066	0.00239259289062426	ICAM1/DRD4/GRIN2A/DBH	4
BP	GO:0008209	androgen metabolic process	4/365	30/18862	0.00253939117237502	0.00622537395607066	0.00239259289062426	SPP1/CYP19A1/CYP17A1/SHH	4
BP	GO:0019934	cGMP-mediated signaling	4/365	30/18862	0.00253939117237502	0.00622537395607066	0.00239259289062426	NPPA/EDNRB/APOE/HTR2C	4
BP	GO:0036474	cell death in response to hydrogen peroxide	4/365	30/18862	0.00253939117237502	0.00622537395607066	0.00239259289062426	PINK1/TXN/LRRK2/IL10	4
BP	GO:0042755	eating behavior	4/365	30/18862	0.00253939117237502	0.00622537395607066	0.00239259289062426	MTOR/LEP/GHRL/GDF15	4
BP	GO:0045948	positive regulation of translational initiation	4/365	30/18862	0.00253939117237502	0.00622537395607066	0.00239259289062426	CCL5/DNAJC3/MTOR/PPP1R15A	4
BP	GO:0060148	positive regulation of posttranscriptional gene silencing	4/365	30/18862	0.00253939117237502	0.00622537395607066	0.00239259289062426	AGO2/EGFR/IL6/BMP4	4
BP	GO:0070633	transepithelial transport	4/365	30/18862	0.00253939117237502	0.00622537395607066	0.00239259289062426	EDNRB/EDN1/CFTR/ITPR1	4
BP	GO:0099068	postsynapse assembly	4/365	30/18862	0.00253939117237502	0.00622537395607066	0.00239259289062426	CEL/NLGN3/CDH2/NRXN1	4
BP	GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	4/365	30/18862	0.00253939117237502	0.00622537395607066	0.00239259289062426	MIF/BCL2/CXCL12/CLU	4
BP	GO:1902751	positive regulation of cell cycle G2/M phase transition	4/365	30/18862	0.00253939117237502	0.00622537395607066	0.00239259289062426	MECP2/BRD4/CCND1/APP	4
BP	GO:2000406	positive regulation of T cell migration	4/365	30/18862	0.00253939117237502	0.00622537395607066	0.00239259289062426	CCL5/CXCL12/APP/ADAM10	4
BP	GO:0046031	ADP metabolic process	8/365	122/18862	0.00258897876231698	0.00634396762264376	0.00243817189768763	NUPR1/EP300/P2RX7/HDAC4/PPARA/APP/IFNG/IGF1	8
BP	GO:0006338	chromatin remodeling	11/365	209/18862	0.00259664460285875	0.00635679974338761	0.00244310365617797	DNMT3A/HCFC1/PHF8/ARID1B/HDAC4/DNMT1/CHD7/TET1/SATB2/MYC/CDKN2A	11
BP	GO:0045216	cell-cell junction organization	11/365	209/18862	0.00259664460285875	0.00635679974338761	0.00244310365617797	OCLN/CTNNB1/GJA1/SRC/PRKCA/AGT/CDH2/VEGFA/ADAM10/CAV1/TRPV4	11
BP	GO:0000045	autophagosome assembly	7/365	96/18862	0.00261869275986239	0.00640478406781297	0.00246154543241369	GABARAP/MAP1LC3A/NUPR1/PINK1/WDR45/UBQLN2/LRRK2	7
BP	GO:0048010	vascular endothelial growth factor receptor signaling pathway	7/365	96/18862	0.00261869275986239	0.00640478406781297	0.00246154543241369	PIK3R2/CYBB/HSP90AA1/HSPB1/SRC/KDR/VEGFA	7
BP	GO:0002753	cytoplasmic pattern recognition receptor signaling pathway	6/365	72/18862	0.00269045400553089	0.0065649586316777	0.00252310519178973	RPS27A/NFKBIA/IKBKG/XIAP/HSPA1B/HSPA1A	6
BP	GO:0030032	lamellipodium assembly	6/365	72/18862	0.00269045400553089	0.0065649586316777	0.00252310519178973	OCLN/ATP7A/MTOR/HDAC4/KIT/P2RY12	6
BP	GO:0033627	cell adhesion mediated by integrin	6/365	72/18862	0.00269045400553089	0.0065649586316777	0.00252310519178973	CCL5/ICAM1/PIK3CG/SERPINE1/FBN1/P2RY12	6
BP	GO:0036465	synaptic vesicle recycling	6/365	72/18862	0.00269045400553089	0.0065649586316777	0.00252310519178973	CEL/SNCA/LRRK2/CANX/NLGN3/SLC2A4	6
BP	GO:0070988	demethylation	6/365	72/18862	0.00269045400553089	0.0065649586316777	0.00252310519178973	CYP3A5/USP9X/PHF8/CYP2D6/TET1/CYP1A1	6
BP	GO:0051224	negative regulation of protein transport	8/365	123/18862	0.00272357357505395	0.00662848895843442	0.00254752175041091	TXN/UBE2J1/UCP2/LRRK2/APOE/GHRL/DRD4/ADIPOQ	8
BP	GO:0008347	glial cell migration	5/365	50/18862	0.00273861735047021	0.00662848895843442	0.00254752175041091	GLI3/RTN4/CCL2/P2RY12/FOXG1	5
BP	GO:0031113	regulation of microtubule polymerization	5/365	50/18862	0.00273861735047021	0.00662848895843442	0.00254752175041091	OCLN/MECP2/SNCA/HSPA1B/HSPA1A	5
BP	GO:0046460	neutral lipid biosynthetic process	5/365	50/18862	0.00273861735047021	0.00662848895843442	0.00254752175041091	MFSD2A/ACSL4/LPL/PLA2G4A/C3	5
BP	GO:0046463	acylglycerol biosynthetic process	5/365	50/18862	0.00273861735047021	0.00662848895843442	0.00254752175041091	MFSD2A/ACSL4/LPL/PLA2G4A/C3	5
BP	GO:0051339	regulation of lyase activity	5/365	50/18862	0.00273861735047021	0.00662848895843442	0.00254752175041091	EDNRB/NF1/CRHR1/NOS2/NOS1	5
BP	GO:0099172	presynapse organization	5/365	50/18862	0.00273861735047021	0.00662848895843442	0.00254752175041091	CEL/SNCA/NLGN3/APP/IL1RAPL1	5
BP	GO:0002827	positive regulation of T-helper 1 type immune response	3/365	15/18862	0.00275068361056927	0.00662848895843442	0.00254752175041091	IL18/IL1R1/PLA2G4A	3
BP	GO:0010713	negative regulation of collagen metabolic process	3/365	15/18862	0.00275068361056927	0.00662848895843442	0.00254752175041091	PPARG/CST3/IL6	3
BP	GO:0010832	negative regulation of myotube differentiation	3/365	15/18862	0.00275068361056927	0.00662848895843442	0.00254752175041091	XBP1/HDAC4/NOTCH1	3
BP	GO:0015671	oxygen transport	3/365	15/18862	0.00275068361056927	0.00662848895843442	0.00254752175041091	HBA1/HBB/MYC	3
BP	GO:0031054	pre-miRNA processing	3/365	15/18862	0.00275068361056927	0.00662848895843442	0.00254752175041091	AGO1/AGO2/DICER1	3
BP	GO:0035635	entry of bacterium into host cell	3/365	15/18862	0.00275068361056927	0.00662848895843442	0.00254752175041091	CTNNB1/SRC/CAV1	3
BP	GO:0042159	lipoprotein catabolic process	3/365	15/18862	0.00275068361056927	0.00662848895843442	0.00254752175041091	ATM/APOE/CTSD	3
BP	GO:0043584	nose development	3/365	15/18862	0.00275068361056927	0.00662848895843442	0.00254752175041091	GLI3/CHD7/DLX5	3
BP	GO:0046321	positive regulation of fatty acid oxidation	3/365	15/18862	0.00275068361056927	0.00662848895843442	0.00254752175041091	ABCD1/PPARA/PPARG	3
BP	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	3/365	15/18862	0.00275068361056927	0.00662848895843442	0.00254752175041091	CXCR4/CXCL12/NTRK1	3
BP	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	3/365	15/18862	0.00275068361056927	0.00662848895843442	0.00254752175041091	FURIN/APOE/IFNG	3
BP	GO:0072160	nephron tubule epithelial cell differentiation	3/365	15/18862	0.00275068361056927	0.00662848895843442	0.00254752175041091	MEF2C/CTNNB1/STAT1	3
BP	GO:0072224	metanephric glomerulus development	3/365	15/18862	0.00275068361056927	0.00662848895843442	0.00254752175041091	PDGFRB/ADIPOQ/EGR1	3
BP	GO:0072283	metanephric renal vesicle morphogenesis	3/365	15/18862	0.00275068361056927	0.00662848895843442	0.00254752175041091	STAT1/BMP4/GDNF	3
BP	GO:1900121	negative regulation of receptor binding	3/365	15/18862	0.00275068361056927	0.00662848895843442	0.00254752175041091	B2M/ADIPOQ/IL10	3
BP	GO:1901163	regulation of trophoblast cell migration	3/365	15/18862	0.00275068361056927	0.00662848895843442	0.00254752175041091	AGO2/GJA1/VEGFA	3
BP	GO:1902902	negative regulation of autophagosome assembly	3/365	15/18862	0.00275068361056927	0.00662848895843442	0.00254752175041091	NUPR1/PINK1/LRRK2	3
BP	GO:1905906	regulation of amyloid fibril formation	3/365	15/18862	0.00275068361056927	0.00662848895843442	0.00254752175041091	APOE/APP/CLU	3
BP	GO:2000136	regulation of cell proliferation involved in heart morphogenesis	3/365	15/18862	0.00275068361056927	0.00662848895843442	0.00254752175041091	CTNNB1/NOTCH1/BMP4	3
BP	GO:2001028	positive regulation of endothelial cell chemotaxis	3/365	15/18862	0.00275068361056927	0.00662848895843442	0.00254752175041091	HSPB1/KDR/VEGFA	3
BP	GO:0046364	monosaccharide biosynthetic process	7/365	97/18862	0.00277657111166615	0.00667857224193964	0.00256677021787637	EP300/ATF4/PPARA/ATF3/LEP/LEPR/ADIPOQ	7
BP	GO:0050773	regulation of dendrite development	7/365	97/18862	0.00277657111166615	0.00667857224193964	0.00256677021787637	NEDD4L/GSK3B/CUX1/MFSD2A/CDKL5/IL1RAPL1/RELN	7
BP	GO:0098659	inorganic cation import across plasma membrane	7/365	97/18862	0.00277657111166615	0.00667857224193964	0.00256677021787637	ATP1A1/SLC9A6/IFNG/KCNH2/TRPV4/CALCR/SLC6A1	7
BP	GO:0099587	inorganic ion import across plasma membrane	7/365	97/18862	0.00277657111166615	0.00667857224193964	0.00256677021787637	ATP1A1/SLC9A6/IFNG/KCNH2/TRPV4/CALCR/SLC6A1	7
BP	GO:0022406	membrane docking	10/365	181/18862	0.00283259829440173	0.006810206464354	0.00261736109112091	STXBP1/PSEN2/CLN3/HSP90AA1/VAPB/DYNC1H1/ICAM1/ALMS1/CFTR/VCAM1	10
BP	GO:0046395	carboxylic acid catabolic process	12/365	243/18862	0.00285887436893749	0.0068663230036375	0.00263892831485455	CBS/CEL/ABCD1/MTOR/MFSD2A/PPARA/LEP/ALDH3A2/ADIPOQ/CNR1/NOS2/NOS1	12
BP	GO:0071621	granulocyte chemotaxis	8/365	124/18862	0.00286357156342364	0.0068663230036375	0.00263892831485455	CCL5/EDN1/MAPK1/MAPK3/PIK3CG/PPIB/CCL2/THBS4	8
BP	GO:0070972	protein localization to endoplasmic reticulum	9/365	152/18862	0.00286481274885887	0.0068663230036375	0.00263892831485455	RPS27A/RPS6/RPL5/RTN4/GJA1/ANK2/LRRK2/PPP1R15A/RYR2	9
BP	GO:0000737	DNA catabolic process, endonucleolytic	4/365	31/18862	0.00287168151604174	0.0068663230036375	0.00263892831485455	DICER1/HMGB1/IL6/BAX	4
BP	GO:0001516	prostaglandin biosynthetic process	4/365	31/18862	0.00287168151604174	0.0068663230036375	0.00263892831485455	EDN1/MIF/PTGS1/PLA2G4A	4
BP	GO:0003338	metanephros morphogenesis	4/365	31/18862	0.00287168151604174	0.0068663230036375	0.00263892831485455	STAT1/BMP4/PDGFRB/GDNF	4
BP	GO:0010259	multicellular organism aging	4/365	31/18862	0.00287168151604174	0.0068663230036375	0.00263892831485455	EDN1/ATM/LEP/LRRK2	4
BP	GO:0030431	sleep	4/365	31/18862	0.00287168151604174	0.0068663230036375	0.00263892831485455	IL18/FOS/GHRL/GRIN2A	4
BP	GO:0042044	fluid transport	4/365	31/18862	0.00287168151604174	0.0068663230036375	0.00263892831485455	EDNRB/EDN1/CFTR/ITPR1	4
BP	GO:0045070	positive regulation of viral genome replication	4/365	31/18862	0.00287168151604174	0.0068663230036375	0.00263892831485455	CCL5/VAPB/PPARA/NOTCH1	4
BP	GO:0046457	prostanoid biosynthetic process	4/365	31/18862	0.00287168151604174	0.0068663230036375	0.00263892831485455	EDN1/MIF/PTGS1/PLA2G4A	4
BP	GO:2000193	positive regulation of fatty acid transport	4/365	31/18862	0.00287168151604174	0.0068663230036375	0.00263892831485455	EDN1/STXBP1/TNFSF11/PLA2G4A	4
BP	GO:1903556	negative regulation of tumor necrosis factor superfamily cytokine production	6/365	73/18862	0.00288462249313987	0.00689411604068223	0.00264960999009387	DICER1/GHRL/IGF1/ADIPOQ/POMC/IL10	6
BP	GO:0030178	negative regulation of Wnt signaling pathway	11/365	212/18862	0.00289768994832467	0.00692218584643147	0.00266039803562346	GLI3/GSK3B/DDIT3/SOX2/APOE/NOTCH1/CDH2/EGR1/CAV1/BMP2/SHH	11
BP	GO:0021761	limbic system development	7/365	98/18862	0.00294164841638661	0.00702399078985744	0.00269952464642471	GLI3/GSK3B/MFSD2A/ETS1/FGFR2/BAX/RELN	7
BP	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	10/365	182/18862	0.00294716459429033	0.00703395325422508	0.00270335351222254	CD4/IKBKG/PINK1/BRD4/TNFRSF1A/GJA1/FASLG/HLA-DRB1/TNFSF11/ADIPOQ	10
BP	GO:0006636	unsaturated fatty acid biosynthetic process	5/365	51/18862	0.00298897303359862	0.00712723683729165	0.00273920511555303	ABCD1/EDN1/MIF/PTGS1/PLA2G4A	5
BP	GO:0030514	negative regulation of BMP signaling pathway	5/365	51/18862	0.00298897303359862	0.00712723683729165	0.00273920511555303	LRP2/SORL1/PPARG/NOTCH1/FBN1	5
BP	GO:0010976	positive regulation of neuron projection development	9/365	153/18862	0.00299336885367261	0.00713446838803391	0.00274198441154653	EP300/SCARB2/MTOR/SETX/APOE/SERPINI1/CNR1/NTRK1/RELN	9
BP	GO:0048705	skeletal system morphogenesis	11/365	213/18862	0.0030040662858406	0.00715670593540723	0.00275053094997551	COL2A1/MEF2C/CTNNB1/GLI3/MED12/FGFR2/DLX5/BMP4/SATB2/MMP2/TRPV4	11
BP	GO:0005977	glycogen metabolic process	6/365	74/18862	0.00308908532147205	0.00735255687702806	0.00282580218249113	MTOR/GSK3B/HMGB1/LEPR/IGF1/POMC	6
BP	GO:0061045	negative regulation of wound healing	6/365	74/18862	0.00308908532147205	0.00735255687702806	0.00282580218249113	EDN1/PLAT/GJA1/APOE/SERPINE1/PROC	6
BP	GO:0015980	energy derivation by oxidation of organic compounds	13/365	278/18862	0.00311378797146312	0.00740798465574454	0.00284710469543829	NDUFS4/PINK1/MTOR/GSK3B/SNCA/HMGB1/LEP/LEPR/IFNG/IGF1/MYC/POMC/NOS2	13
BP	GO:0006959	humoral immune response	16/365	380/18862	0.00314714514734928	0.00748394261754936	0.00287629755689255	PTPRC/BCL2/MEF2C/ATP7A/PLA2G6/TF/IL6/NOTCH1/C4A/CCL2/HLA-DRB1/IFNG/CLU/HLA-DQB1/C3/MBL2	16
BP	GO:0002861	regulation of inflammatory response to antigenic stimulus	4/365	32/18862	0.00323252169992027	0.00766607094580094	0.00294629478861404	HLA-DRB1/CNR1/C3/IL10	4
BP	GO:0010165	response to X-ray	4/365	32/18862	0.00323252169992027	0.00766607094580094	0.00294629478861404	ATM/CCND1/CDKN1A/BRCA2	4
BP	GO:0031128	developmental induction	4/365	32/18862	0.00323252169992027	0.00766607094580094	0.00294629478861404	AR/BMP4/GDNF/BMP2	4
BP	GO:0033687	osteoblast proliferation	4/365	32/18862	0.00323252169992027	0.00766607094580094	0.00294629478861404	BCL2/EIF2AK2/FGFR2/BMP2	4
BP	GO:0048333	mesodermal cell differentiation	4/365	32/18862	0.00323252169992027	0.00766607094580094	0.00294629478861404	KLF4/GJA1/FGFR2/BMP4	4
BP	GO:0050974	detection of mechanical stimulus involved in sensory perception	4/365	32/18862	0.00323252169992027	0.00766607094580094	0.00294629478861404	CXCR4/CXCL12/KIT/NTRK1	4
BP	GO:0031103	axon regeneration	5/365	52/18862	0.00325543657652283	0.00770296340032571	0.00296047363554541	SPP1/KLF4/BCL2/DAG1/MTR	5
BP	GO:0032210	regulation of telomere maintenance via telomerase	5/365	52/18862	0.00325543657652283	0.00770296340032571	0.00296047363554541	HNRNPA1/MAPK1/ATM/MAPK3/SRC	5
BP	GO:0050819	negative regulation of coagulation	5/365	52/18862	0.00325543657652283	0.00770296340032571	0.00296047363554541	EDN1/PLAT/APOE/SERPINE1/PROC	5
BP	GO:0060350	endochondral bone morphogenesis	5/365	52/18862	0.00325543657652283	0.00770296340032571	0.00296047363554541	COL2A1/MEF2C/DLX5/BMP4/TRPV4	5
BP	GO:0072666	establishment of protein localization to vacuole	5/365	52/18862	0.00325543657652283	0.00770296340032571	0.00296047363554541	SORT1/SCARB2/SORL1/LAMP2/CLU	5
BP	GO:0007269	neurotransmitter secretion	9/365	155/18862	0.00326412468358781	0.00771654408035168	0.00296569308721357	STXBP1/MEF2C/DNAJC5/GSK3B/SNCA/LRRK2/CNR1/CAMK2A/NRXN1	9
BP	GO:0099643	signal release from synapse	9/365	155/18862	0.00326412468358781	0.00771654408035168	0.00296569308721357	STXBP1/MEF2C/DNAJC5/GSK3B/SNCA/LRRK2/CNR1/CAMK2A/NRXN1	9
BP	GO:0010717	regulation of epithelial to mesenchymal transition	7/365	100/18862	0.00329424984533833	0.00778073271231986	0.00299036265173929	DAG1/CTNNB1/MTOR/IL6/NOTCH1/BMP4/BMP2	7
BP	GO:0030219	megakaryocyte differentiation	7/365	100/18862	0.00329424984533833	0.00778073271231986	0.00299036265173929	MEF2C/AGO1/EP300/KMT2A/KMT2D/KMT2C/KIT	7
BP	GO:0002200	somatic diversification of immune receptors	6/365	75/18862	0.00330417432700957	0.00779094264931736	0.00299428662849094	PTPRC/PRKDC/ATM/HMGB1/CD40LG/IL10	6
BP	GO:0006073	cellular glucan metabolic process	6/365	75/18862	0.00330417432700957	0.00779094264931736	0.00299428662849094	MTOR/GSK3B/HMGB1/LEPR/IGF1/POMC	6
BP	GO:0044042	glucan metabolic process	6/365	75/18862	0.00330417432700957	0.00779094264931736	0.00299428662849094	MTOR/GSK3B/HMGB1/LEPR/IGF1/POMC	6
BP	GO:1904950	negative regulation of establishment of protein localization	8/365	127/18862	0.00331745116190126	0.00779094264931736	0.00299428662849094	TXN/UBE2J1/UCP2/LRRK2/APOE/GHRL/DRD4/ADIPOQ	8
BP	GO:0002693	positive regulation of cellular extravasation	3/365	16/18862	0.0033372742490962	0.00779094264931736	0.00299428662849094	ICAM1/IL1R1/AGER	3
BP	GO:0002830	positive regulation of type 2 immune response	3/365	16/18862	0.0033372742490962	0.00779094264931736	0.00299428662849094	IL18/IL6/NLRP3	3
BP	GO:0010224	response to UV-B	3/365	16/18862	0.0033372742490962	0.00779094264931736	0.00299428662849094	BCL2/CDKN1A/MME	3
BP	GO:0017014	protein nitrosylation	3/365	16/18862	0.0033372742490962	0.00779094264931736	0.00299428662849094	TXN/NOS2/NOS1	3
BP	GO:0018119	peptidyl-cysteine S-nitrosylation	3/365	16/18862	0.0033372742490962	0.00779094264931736	0.00299428662849094	TXN/NOS2/NOS1	3
BP	GO:0021924	cell proliferation in external granule layer	3/365	16/18862	0.0033372742490962	0.00779094264931736	0.00299428662849094	RORA/SHH/SLC6A4	3
BP	GO:0021930	cerebellar granule cell precursor proliferation	3/365	16/18862	0.0033372742490962	0.00779094264931736	0.00299428662849094	RORA/SHH/SLC6A4	3
BP	GO:0030540	female genitalia development	3/365	16/18862	0.0033372742490962	0.00779094264931736	0.00299428662849094	LRP2/CHD7/BAX	3
BP	GO:0033151	V(D)J recombination	3/365	16/18862	0.0033372742490962	0.00779094264931736	0.00299428662849094	PRKDC/ATM/HMGB1	3
BP	GO:0036035	osteoclast development	3/365	16/18862	0.0033372742490962	0.00779094264931736	0.00299428662849094	SRC/TNFSF11/FBN1	3
BP	GO:0043923	positive regulation by host of viral transcription	3/365	16/18862	0.0033372742490962	0.00779094264931736	0.00299428662849094	EP300/SP1/JUN	3
BP	GO:0045346	regulation of MHC class II biosynthetic process	3/365	16/18862	0.0033372742490962	0.00779094264931736	0.00299428662849094	XBP1/IFNG/IL10	3
BP	GO:0045591	positive regulation of regulatory T cell differentiation	3/365	16/18862	0.0033372742490962	0.00779094264931736	0.00299428662849094	HLA-DRB1/IFNG/SOCS1	3
BP	GO:0048557	embryonic digestive tract morphogenesis	3/365	16/18862	0.0033372742490962	0.00779094264931736	0.00299428662849094	GLI3/FGFR2/SHH	3
BP	GO:0061323	cell proliferation involved in heart morphogenesis	3/365	16/18862	0.0033372742490962	0.00779094264931736	0.00299428662849094	CTNNB1/NOTCH1/BMP4	3
BP	GO:0061450	trophoblast cell migration	3/365	16/18862	0.0033372742490962	0.00779094264931736	0.00299428662849094	AGO2/GJA1/VEGFA	3
BP	GO:0070230	positive regulation of lymphocyte apoptotic process	3/365	16/18862	0.0033372742490962	0.00779094264931736	0.00299428662849094	CCL5/BAX/IL10	3
BP	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	3/365	16/18862	0.0033372742490962	0.00779094264931736	0.00299428662849094	NFKBIA/HSPA1B/HSPA1A	3
BP	GO:0071361	cellular response to ethanol	3/365	16/18862	0.0033372742490962	0.00779094264931736	0.00299428662849094	CYBB/DNMT3A/SOD2	3
BP	GO:0072044	collecting duct development	3/365	16/18862	0.0033372742490962	0.00779094264931736	0.00299428662849094	NOTCH1/BMP4/SHH	3
BP	GO:1901201	regulation of extracellular matrix assembly	3/365	16/18862	0.0033372742490962	0.00779094264931736	0.00299428662849094	DAG1/NOTCH1/AGT	3
BP	GO:1903204	negative regulation of oxidative stress-induced neuron death	3/365	16/18862	0.0033372742490962	0.00779094264931736	0.00299428662849094	PINK1/ATF4/IL10	3
BP	GO:0030500	regulation of bone mineralization	6/365	76/18862	0.0035302231256115	0.00823771192128871	0.00316599309807991	MEF2C/P2RX7/ADRB2/BGLAP/BMP4/BMP2	6
BP	GO:0002720	positive regulation of cytokine production involved in immune response	5/365	53/18862	0.00353858065223773	0.00824251496831877	0.00316783904922414	IL18/IL1R1/B2M/IL6/NLRP3	5
BP	GO:0048016	inositol phosphate-mediated signaling	5/365	53/18862	0.00353858065223773	0.00824251496831877	0.00316783904922414	EDN1/MTOR/GSK3B/ITPR1/IGF1	5
BP	GO:0090151	establishment of protein localization to mitochondrial membrane	5/365	53/18862	0.00353858065223773	0.00824251496831877	0.00316783904922414	BCL2/BCS1L/HSP90AA1/BCL2L11/BAX	5
BP	GO:1902743	regulation of lamellipodium organization	5/365	53/18862	0.00353858065223773	0.00824251496831877	0.00316783904922414	OCLN/ATP7A/MTOR/HDAC4/SRC	5
BP	GO:0010810	regulation of cell-substrate adhesion	11/365	218/18862	0.00358409092289236	0.00834480955979476	0.00320715384606073	BCL2/DAG1/NF1/GSK3B/SRC/KDR/NOTCH1/SERPINE1/VEGFA/FN1/CDKN2A	11
BP	GO:0016579	protein deubiquitination	13/365	283/18862	0.00362199334629008	0.00840189572522135	0.00322909372541842	RPS27A/NFKBIA/IKBKG/HCFC1/USP9X/EP300/BRCA1/CFTR/ADRB2/AR/NLRP3/MYC/UCHL1	13
BP	GO:0030262	apoptotic nuclear changes	4/365	33/18862	0.00362305667784192	0.00840189572522135	0.00322909372541842	DICER1/HMGB1/IL6/BAX	4
BP	GO:0032212	positive regulation of telomere maintenance via telomerase	4/365	33/18862	0.00362305667784192	0.00840189572522135	0.00322909372541842	HNRNPA1/MAPK1/ATM/MAPK3	4
BP	GO:0032350	regulation of hormone metabolic process	4/365	33/18862	0.00362305667784192	0.00840189572522135	0.00322909372541842	ATP1A1/STUB1/EGR1/BMP2	4
BP	GO:0032770	positive regulation of monooxygenase activity	4/365	33/18862	0.00362305667784192	0.00840189572522135	0.00322909372541842	APOE/TERT/IFNG/GDNF	4
BP	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	4/365	33/18862	0.00362305667784192	0.00840189572522135	0.00322909372541842	SRC/KIT/PDGFRB/P2RY12	4
BP	GO:0045589	regulation of regulatory T cell differentiation	4/365	33/18862	0.00362305667784192	0.00840189572522135	0.00322909372541842	CTLA4/HLA-DRB1/IFNG/SOCS1	4
BP	GO:0055094	response to lipoprotein particle	4/365	33/18862	0.00362305667784192	0.00840189572522135	0.00322909372541842	PPARG/APOE/ABCA1/LPL	4
BP	GO:0060251	regulation of glial cell proliferation	4/365	33/18862	0.00362305667784192	0.00840189572522135	0.00322909372541842	MTOR/DICER1/IL6/NOTCH1	4
BP	GO:0009100	glycoprotein metabolic process	17/365	421/18862	0.00362822545547891	0.00841015590521551	0.0032322683536526	COL2A1/BCL2/UGGT1/CTNNB1/AGO2/ATP7A/ITM2B/PMM2/POMGNT1/MAN2B1/ALG13/UBE2J1/LEP/CST3/TET1/IGF1/BMP2	17
BP	GO:0019079	viral genome replication	8/365	129/18862	0.00364976715385814	0.00845634408290993	0.00325001981828146	CCL5/BCL2/EIF2AK2/VAPB/PPARA/NOTCH1/PPIB/CCL2	8
BP	GO:0044106	cellular amine metabolic process	9/365	158/18862	0.00370601639775389	0.00858287160435569	0.00329864803731145	MAOA/ATP7A/CLN3/MECP2/SNCA/DRD4/GRIN2A/NQO1/DBH	9
BP	GO:0009953	dorsal/ventral pattern formation	6/365	77/18862	0.0037675668563337	0.00871000217581739	0.00334750802606179	EDN1/GLI3/DDIT3/BMP4/FOXG1/SHH	6
BP	GO:0046785	microtubule polymerization	6/365	77/18862	0.0037675668563337	0.00871000217581739	0.00334750802606179	OCLN/MECP2/SNCA/HSPA1B/HSPA1A/TRPV4	6
BP	GO:0051205	protein insertion into membrane	6/365	77/18862	0.0037675668563337	0.00871000217581739	0.00334750802606179	BCL2/BCS1L/HSP90AA1/BCL2L11/EGFR/BAX	6
BP	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	6/365	77/18862	0.0037675668563337	0.00871000217581739	0.00334750802606179	RPS27A/EP300/CREBBP/NOTCH1/VEGFA/EGR1	6
BP	GO:0002381	immunoglobulin production involved in immunoglobulin-mediated immune response	5/365	54/18862	0.00383897682363398	0.00886334569691233	0.00340644241634645	PTPRC/HLA-DRB1/HLA-DQB1/CD40LG/IL10	5
BP	GO:0010676	positive regulation of cellular carbohydrate metabolic process	5/365	54/18862	0.00383897682363398	0.00886334569691233	0.00340644241634645	SNCA/PPARA/SRC/HMGB1/IGF1	5
BP	GO:0035065	regulation of histone acetylation	5/365	54/18862	0.00383897682363398	0.00886334569691233	0.00340644241634645	KMT2A/SNCA/MAPK3/BRCA1/NOS1	5
BP	GO:0007093	mitotic cell cycle checkpoint	9/365	159/18862	0.00386329608584845	0.00891556072016349	0.00342651017360828	EP300/PRKDC/GADD45A/ATM/BRCA1/CCND1/CDKN1A/BAX/AURKA	9
BP	GO:0006576	cellular biogenic amine metabolic process	7/365	103/18862	0.00388250239797367	0.00895199011057013	0.00344051105148513	MAOA/ATP7A/MECP2/SNCA/DRD4/GRIN2A/DBH	7
BP	GO:0055002	striated muscle cell development	7/365	103/18862	0.00388250239797367	0.00895199011057013	0.00344051105148513	EDN1/BCL2/HDAC4/BMP4/KRT8/PDGFRB/VEGFA	7
BP	GO:0032970	regulation of actin filament-based process	16/365	389/18862	0.00394639834895217	0.00909074457849853	0.00349383844287567	EDN1/HRAS/ATP1A1/MTOR/ICAM1/GATA4/ANK2/ALMS1/ELN/CXCL12/CSF3/PDGFRB/RYR2/NOX4/CAV1/SCN5A	16
BP	GO:0002440	production of molecular mediator of immune response	13/365	286/18862	0.00395791370018527	0.00909074457849853	0.00349383844287567	XBP1/PTPRC/PRKDC/IL18/IL1R1/B2M/IL6/KIT/HLA-DRB1/NLRP3/HLA-DQB1/CD40LG/IL10	13
BP	GO:2001020	regulation of response to DNA damage stimulus	11/365	221/18862	0.00397303848291807	0.00909074457849853	0.00349383844287567	MIF/BCL2/PARP1/PRKDC/ATM/BRCA1/EGFR/HMGB1/CXCL12/MYC/CLU	11
BP	GO:0000097	sulfur amino acid biosynthetic process	3/365	17/18862	0.00399478649800279	0.00909074457849853	0.00349383844287567	CBS/MTR/MTHFR	3
BP	GO:0003085	negative regulation of systemic arterial blood pressure	3/365	17/18862	0.00399478649800279	0.00909074457849853	0.00349383844287567	NPPA/ADRB2/SOD2	3
BP	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	3/365	17/18862	0.00399478649800279	0.00909074457849853	0.00349383844287567	BRCA1/CDKN1A/BRCA2	3
BP	GO:0010523	negative regulation of calcium ion transport into cytosol	3/365	17/18862	0.00399478649800279	0.00909074457849853	0.00349383844287567	BCL2/CASQ2/NOS1	3
BP	GO:0010715	regulation of extracellular matrix disassembly	3/365	17/18862	0.00399478649800279	0.00909074457849853	0.00349383844287567	ETS1/CST3/IL6	3
BP	GO:0010759	positive regulation of macrophage chemotaxis	3/365	17/18862	0.00399478649800279	0.00909074457849853	0.00349383844287567	CCL5/MAPK1/MAPK3	3
BP	GO:0016246	RNA interference	3/365	17/18862	0.00399478649800279	0.00909074457849853	0.00349383844287567	AGO2/DICER1/TERT	3
BP	GO:0021534	cell proliferation in hindbrain	3/365	17/18862	0.00399478649800279	0.00909074457849853	0.00349383844287567	RORA/SHH/SLC6A4	3
BP	GO:0030730	sequestering of triglyceride	3/365	17/18862	0.00399478649800279	0.00909074457849853	0.00349383844287567	PPARA/PPARG/LPL	3
BP	GO:0030889	negative regulation of B cell proliferation	3/365	17/18862	0.00399478649800279	0.00909074457849853	0.00349383844287567	ATM/CTLA4/IL10	3
BP	GO:0031000	response to caffeine	3/365	17/18862	0.00399478649800279	0.00909074457849853	0.00349383844287567	PPARG/RYR2/CASQ2	3
BP	GO:0031065	positive regulation of histone deacetylation	3/365	17/18862	0.00399478649800279	0.00909074457849853	0.00349383844287567	PINK1/LRRK2/VEGFA	3
BP	GO:0032305	positive regulation of icosanoid secretion	3/365	17/18862	0.00399478649800279	0.00909074457849853	0.00349383844287567	EDN1/TNFSF11/PLA2G4A	3
BP	GO:0042753	positive regulation of circadian rhythm	3/365	17/18862	0.00399478649800279	0.00909074457849853	0.00349383844287567	ARNTL/RORA/GHRL	3
BP	GO:0043217	myelin maintenance	3/365	17/18862	0.00399478649800279	0.00909074457849853	0.00349383844287567	ABCD1/CXCR4/CLU	3
BP	GO:0045342	MHC class II biosynthetic process	3/365	17/18862	0.00399478649800279	0.00909074457849853	0.00349383844287567	XBP1/IFNG/IL10	3
BP	GO:0050961	detection of temperature stimulus involved in sensory perception	3/365	17/18862	0.00399478649800279	0.00909074457849853	0.00349383844287567	CXCR4/CXCL12/NTRK1	3
BP	GO:0055070	copper ion homeostasis	3/365	17/18862	0.00399478649800279	0.00909074457849853	0.00349383844287567	ATP7A/XIAP/APP	3
BP	GO:0055089	fatty acid homeostasis	3/365	17/18862	0.00399478649800279	0.00909074457849853	0.00349383844287567	XBP1/ABCD1/APOE	3
BP	GO:0060602	branch elongation of an epithelium	3/365	17/18862	0.00399478649800279	0.00909074457849853	0.00349383844287567	FGFR2/BMP4/SHH	3
BP	GO:0072567	chemokine (C-X-C motif) ligand 2 production	3/365	17/18862	0.00399478649800279	0.00909074457849853	0.00349383844287567	KLF4/HMGB1/LPL	3
BP	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	3/365	17/18862	0.00399478649800279	0.00909074457849853	0.00349383844287567	AGT/GDNF/VEGFA	3
BP	GO:0090494	dopamine uptake	3/365	17/18862	0.00399478649800279	0.00909074457849853	0.00349383844287567	SNCA/DRD4/GDNF	3
BP	GO:1901550	regulation of endothelial cell development	3/365	17/18862	0.00399478649800279	0.00909074457849853	0.00349383844287567	TNFRSF1A/VEGFA/PROC	3
BP	GO:1903140	regulation of establishment of endothelial barrier	3/365	17/18862	0.00399478649800279	0.00909074457849853	0.00349383844287567	TNFRSF1A/VEGFA/PROC	3
BP	GO:2000341	regulation of chemokine (C-X-C motif) ligand 2 production	3/365	17/18862	0.00399478649800279	0.00909074457849853	0.00349383844287567	KLF4/HMGB1/LPL	3
BP	GO:2001267	regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	3/365	17/18862	0.00399478649800279	0.00909074457849853	0.00349383844287567	MMP9/FAS/BAX	3
BP	GO:0046578	regulation of Ras protein signal transduction	10/365	190/18862	0.0040028544267874	0.00910514561921132	0.00349937318309692	HRAS/NGF/PIK3CG/APOE/NOTCH1/KITLG/ABCA1/IGF1/PDGFRB/NTRK1	10
BP	GO:0002691	regulation of cellular extravasation	4/365	34/18862	0.00404440884574688	0.00917574161189388	0.00352650528333552	ICAM1/IL1R1/AGER/CXCL12	4
BP	GO:0009112	nucleobase metabolic process	4/365	34/18862	0.00404440884574688	0.00917574161189388	0.00352650528333552	MTOR/MAPK1/TTR/XDH	4
BP	GO:0035137	hindlimb morphogenesis	4/365	34/18862	0.00404440884574688	0.00917574161189388	0.00352650528333552	CHD7/NOTCH1/BMP4/SHH	4
BP	GO:0036314	response to sterol	4/365	34/18862	0.00404440884574688	0.00917574161189388	0.00352650528333552	CCR5/DAG1/RORA/GRAMD1B	4
BP	GO:0071402	cellular response to lipoprotein particle stimulus	4/365	34/18862	0.00404440884574688	0.00917574161189388	0.00352650528333552	PPARG/APOE/ABCA1/LPL	4
BP	GO:2000352	negative regulation of endothelial cell apoptotic process	4/365	34/18862	0.00404440884574688	0.00917574161189388	0.00352650528333552	ICAM1/KDR/TERT/SERPINE1	4
BP	GO:1901605	alpha-amino acid metabolic process	10/365	191/18862	0.00415349468708162	0.00941122751566529	0.00361700938849956	CBS/ATP7A/CLN3/MTR/MECP2/ATF4/MTHFR/NOX4/NOS2/NOS1	10
BP	GO:0031529	ruffle organization	5/365	55/18862	0.00415719488273178	0.00941122751566529	0.00361700938849956	HRAS/MTOR/ICAM1/CAV1/P2RY12	5
BP	GO:0071385	cellular response to glucocorticoid stimulus	5/365	55/18862	0.00415719488273178	0.00941122751566529	0.00361700938849956	EDN1/EIF4E/ICAM1/BCL2L11/EGFR	5
BP	GO:0097345	mitochondrial outer membrane permeabilization	5/365	55/18862	0.00415719488273178	0.00941122751566529	0.00361700938849956	BCL2/GSK3B/BCL2L11/HSPA1A/BAX	5
BP	GO:0098900	regulation of action potential	5/365	55/18862	0.00415719488273178	0.00941122751566529	0.00361700938849956	ANK2/RYR2/CNR1/CAV1/SCN5A	5
BP	GO:0098739	import across plasma membrane	9/365	161/18862	0.00419351147629824	0.00948933811800476	0.00364702957253325	LRP2/ATP1A1/SLC9A6/SLC2A1/IFNG/KCNH2/TRPV4/CALCR/SLC6A1	9
BP	GO:0006165	nucleoside diphosphate phosphorylation	8/365	132/18862	0.0041958781473523	0.00949059041626705	0.00364751086730212	NUPR1/EP300/P2RX7/HDAC4/PPARA/APP/IFNG/IGF1	8
BP	GO:0022412	cellular process involved in reproduction in multicellular organism	15/365	357/18862	0.00426376721623126	0.00963998168887881	0.00370492629315355	BCL2/DNMT3A/RPS6/MTOR/KMT2D/UBE2J1/ATM/SRC/CFTR/BRCA2/BMP4/KIT/BAX/IGF1/AURKA	15
BP	GO:1904029	regulation of cyclin-dependent protein kinase activity	7/365	105/18862	0.004316788778257	0.00975564441511102	0.0037493788543083	HSP90AB1/GADD45A/SRC/EGFR/CCND1/CDKN1A/CDKN2A	7
BP	GO:0046939	nucleotide phosphorylation	8/365	133/18862	0.00439123777781252	0.00991961093183891	0.00381239597183278	NUPR1/EP300/P2RX7/HDAC4/PPARA/APP/IFNG/IGF1	8
BP	GO:0010559	regulation of glycoprotein biosynthetic process	5/365	56/18862	0.00449380220508854	0.0101077020972753	0.00388468489590193	BCL2/CTNNB1/AGO2/ITM2B/IGF1	5
BP	GO:0003230	cardiac atrium development	4/365	35/18862	0.00449767638222282	0.0101077020972753	0.00388468489590193	GATA4/ANK2/NOTCH1/BMP2	4
BP	GO:0006921	cellular component disassembly involved in execution phase of apoptosis	4/365	35/18862	0.00449767638222282	0.0101077020972753	0.00388468489590193	DICER1/HMGB1/IL6/BAX	4
BP	GO:0010765	positive regulation of sodium ion transport	4/365	35/18862	0.00449767638222282	0.0101077020972753	0.00388468489590193	ANK3/DRD4/SCN5A/NOS1	4
BP	GO:0016242	negative regulation of macroautophagy	4/365	35/18862	0.00449767638222282	0.0101077020972753	0.00388468489590193	NUPR1/PINK1/MTOR/LRRK2	4
BP	GO:0032205	negative regulation of telomere maintenance	4/365	35/18862	0.00449767638222282	0.0101077020972753	0.00388468489590193	PARP1/HNRNPA1/ATM/SRC	4
BP	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	4/365	35/18862	0.00449767638222282	0.0101077020972753	0.00388468489590193	CFTR/PLA2G6/GHRL/HLA-DRB1	4
BP	GO:0042554	superoxide anion generation	4/365	35/18862	0.00449767638222282	0.0101077020972753	0.00388468489590193	CYBB/EDN1/EGFR/NOX4	4
BP	GO:0048854	brain morphogenesis	4/365	35/18862	0.00449767638222282	0.0101077020972753	0.00388468489590193	AKT3/NF1/CDH2/SLC6A4	4
BP	GO:0050775	positive regulation of dendrite morphogenesis	4/365	35/18862	0.00449767638222282	0.0101077020972753	0.00388468489590193	CUX1/CDKL5/IL1RAPL1/RELN	4
BP	GO:0051354	negative regulation of oxidoreductase activity	4/365	35/18862	0.00449767638222282	0.0101077020972753	0.00388468489590193	SNCA/CNR1/CAV1/HP	4
BP	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	4/365	35/18862	0.00449767638222282	0.0101077020972753	0.00388468489590193	ABCD1/PPARA/CAV1/IL10	4
BP	GO:0032271	regulation of protein polymerization	11/365	225/18862	0.00454326681577427	0.0102057761861642	0.0039223776304245	OCLN/PINK1/MTOR/MECP2/HSP90AA1/ICAM1/SNCA/ELN/HSPA1B/HSPA1A/CSF3	11
BP	GO:0035418	protein localization to synapse	6/365	80/18862	0.00455073649495468	0.0102137885139763	0.0039254570018319	HRAS/DAG1/HSPB1/ADAM10/GRIN2A/NRXN1	6
BP	GO:0070828	heterochromatin organization	6/365	80/18862	0.00455073649495468	0.0102137885139763	0.0039254570018319	DNMT3A/PHF8/DNMT1/MTHFR/TET1/CDKN2A	6
BP	GO:0000086	G2/M transition of mitotic cell cycle	12/365	258/18862	0.00461719495943734	0.0103496352966574	0.00397766688492494	MECP2/HSP90AA1/BRD4/DYNC1H1/RAD21/ATM/BRCA1/ALMS1/CCND1/CDKN1A/APP/AURKA	12
BP	GO:0002833	positive regulation of response to biotic stimulus	12/365	258/18862	0.00461719495943734	0.0103496352966574	0.00397766688492494	MATR3/CCL5/IKBKG/HRAS/EP300/PRKDC/HSP90AA1/CREBBP/SRC/HMGB1/PRKCA/HLA-DRB1	12
BP	GO:0016054	organic acid catabolic process	12/365	258/18862	0.00461719495943734	0.0103496352966574	0.00397766688492494	CBS/CEL/ABCD1/MTOR/MFSD2A/PPARA/LEP/ALDH3A2/ADIPOQ/CNR1/NOS2/NOS1	12
BP	GO:1905475	regulation of protein localization to membrane	10/365	194/18862	0.00463243583478098	0.0103793532359776	0.00398908835628445	BCL2/HRAS/DAG1/CLN3/EGFR/AR/ANK3/IFNG/CDH2/ADAM10	10
BP	GO:0008340	determination of adult lifespan	3/365	18/18862	0.00472565262072744	0.0104805363630879	0.0040279759849287	ATM/LEP/LRRK2	3
BP	GO:0031445	regulation of heterochromatin assembly	3/365	18/18862	0.00472565262072744	0.0104805363630879	0.0040279759849287	PHF8/DNMT1/TET1	3
BP	GO:0032048	cardiolipin metabolic process	3/365	18/18862	0.00472565262072744	0.0104805363630879	0.0040279759849287	MECP2/PLA2G6/PLA2G4A	3
BP	GO:0032769	negative regulation of monooxygenase activity	3/365	18/18862	0.00472565262072744	0.0104805363630879	0.0040279759849287	SNCA/CNR1/CAV1	3
BP	GO:0034433	steroid esterification	3/365	18/18862	0.00472565262072744	0.0104805363630879	0.0040279759849287	AGTR1/APOE/AGT	3
BP	GO:0034434	sterol esterification	3/365	18/18862	0.00472565262072744	0.0104805363630879	0.0040279759849287	AGTR1/APOE/AGT	3
BP	GO:0034435	cholesterol esterification	3/365	18/18862	0.00472565262072744	0.0104805363630879	0.0040279759849287	AGTR1/APOE/AGT	3
BP	GO:0042136	neurotransmitter biosynthetic process	3/365	18/18862	0.00472565262072744	0.0104805363630879	0.0040279759849287	NOS1/SLC6A4/DBH	3
BP	GO:0042772	DNA damage response, signal transduction resulting in transcription	3/365	18/18862	0.00472565262072744	0.0104805363630879	0.0040279759849287	BRCA1/CDKN1A/BRCA2	3
BP	GO:0045721	negative regulation of gluconeogenesis	3/365	18/18862	0.00472565262072744	0.0104805363630879	0.0040279759849287	EP300/LEPR/ADIPOQ	3
BP	GO:0060973	cell migration involved in heart development	3/365	18/18862	0.00472565262072744	0.0104805363630879	0.0040279759849287	NOTCH1/BMP4/PDGFRB	3
BP	GO:0070200	establishment of protein localization to telomere	3/365	18/18862	0.00472565262072744	0.0104805363630879	0.0040279759849287	ATM/BRCA2/TERT	3
BP	GO:0070293	renal absorption	3/365	18/18862	0.00472565262072744	0.0104805363630879	0.0040279759849287	HBB/KCNQ1/ADIPOQ	3
BP	GO:0071243	cellular response to arsenic-containing substance	3/365	18/18862	0.00472565262072744	0.0104805363630879	0.0040279759849287	ATF4/HNRNPA1/ATF3	3
BP	GO:0071498	cellular response to fluid shear stress	3/365	18/18862	0.00472565262072744	0.0104805363630879	0.0040279759849287	KLF4/MEF2C/SRC	3
BP	GO:0071605	monocyte chemotactic protein-1 production	3/365	18/18862	0.00472565262072744	0.0104805363630879	0.0040279759849287	HMGB1/AGER/ADIPOQ	3
BP	GO:0071637	regulation of monocyte chemotactic protein-1 production	3/365	18/18862	0.00472565262072744	0.0104805363630879	0.0040279759849287	HMGB1/AGER/ADIPOQ	3
BP	GO:0072077	renal vesicle morphogenesis	3/365	18/18862	0.00472565262072744	0.0104805363630879	0.0040279759849287	STAT1/BMP4/GDNF	3
BP	GO:0090493	catecholamine uptake	3/365	18/18862	0.00472565262072744	0.0104805363630879	0.0040279759849287	SNCA/DRD4/GDNF	3
BP	GO:0097623	potassium ion export across plasma membrane	3/365	18/18862	0.00472565262072744	0.0104805363630879	0.0040279759849287	NPPA/KCNQ1/KCNH2	3
BP	GO:0120261	regulation of heterochromatin organization	3/365	18/18862	0.00472565262072744	0.0104805363630879	0.0040279759849287	PHF8/DNMT1/TET1	3
BP	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	3/365	18/18862	0.00472565262072744	0.0104805363630879	0.0040279759849287	XBP1/LRRK2/HSPA1A	3
BP	GO:1902683	regulation of receptor localization to synapse	3/365	18/18862	0.00472565262072744	0.0104805363630879	0.0040279759849287	HRAS/DAG1/ADAM10	3
BP	GO:2000641	regulation of early endosome to late endosome transport	3/365	18/18862	0.00472565262072744	0.0104805363630879	0.0040279759849287	MAPK1/MAPK3/SRC	3
BP	GO:1901989	positive regulation of cell cycle phase transition	7/365	107/18862	0.00478683827435184	0.0106072445080261	0.00407667362283808	MECP2/BRD4/EGFR/CCND1/APP/TERT/CYP1A1	7
BP	GO:2001022	positive regulation of response to DNA damage stimulus	7/365	107/18862	0.00478683827435184	0.0106072445080261	0.00407667362283808	PARP1/PRKDC/ATM/BRCA1/EGFR/HMGB1/MYC	7
BP	GO:0009135	purine nucleoside diphosphate metabolic process	8/365	135/18862	0.0048028831732993	0.0106337946400375	0.00408687761340056	NUPR1/EP300/P2RX7/HDAC4/PPARA/APP/IFNG/IGF1	8
BP	GO:0009179	purine ribonucleoside diphosphate metabolic process	8/365	135/18862	0.0048028831732993	0.0106337946400375	0.00408687761340056	NUPR1/EP300/P2RX7/HDAC4/PPARA/APP/IFNG/IGF1	8
BP	GO:0045747	positive regulation of Notch signaling pathway	5/365	57/18862	0.00484936311999581	0.0107276274598724	0.00412294030444988	EP300/CREBBP/SRC/NOTCH1/KIT	5
BP	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	5/365	57/18862	0.00484936311999581	0.0107276274598724	0.00412294030444988	CFTR/UCP2/PLA2G6/GHRL/HLA-DRB1	5
BP	GO:0051258	protein polymerization	13/365	294/18862	0.00497842114891504	0.0109742947714918	0.00421774175096452	OCLN/PINK1/MTOR/MECP2/HSP90AA1/ICAM1/SNCA/ELN/HSPA1B/HSPA1A/CSF3/CASQ2/TRPV4	13
BP	GO:0014037	Schwann cell differentiation	4/365	36/18862	0.00498393172942989	0.0109742947714918	0.00421774175096452	DAG1/NF1/MED12/DICER1	4
BP	GO:0032892	positive regulation of organic acid transport	4/365	36/18862	0.00498393172942989	0.0109742947714918	0.00421774175096452	EDN1/STXBP1/TNFSF11/PLA2G4A	4
BP	GO:0042092	type 2 immune response	4/365	36/18862	0.00498393172942989	0.0109742947714918	0.00421774175096452	IL18/IL6/NLRP3/IL10	4
BP	GO:0045066	regulatory T cell differentiation	4/365	36/18862	0.00498393172942989	0.0109742947714918	0.00421774175096452	CTLA4/HLA-DRB1/IFNG/SOCS1	4
BP	GO:0051930	regulation of sensory perception of pain	4/365	36/18862	0.00498393172942989	0.0109742947714918	0.00421774175096452	EDNRB/EDN1/MTOR/IL10	4
BP	GO:0071392	cellular response to estradiol stimulus	4/365	36/18862	0.00498393172942989	0.0109742947714918	0.00421774175096452	BCL2L11/EGFR/ESR2/IL10	4
BP	GO:0086010	membrane depolarization during action potential	4/365	36/18862	0.00498393172942989	0.0109742947714918	0.00421774175096452	ANK2/ANK3/KCNH2/SCN5A	4
BP	GO:1902742	apoptotic process involved in development	4/365	36/18862	0.00498393172942989	0.0109742947714918	0.00421774175096452	TNFRSF1A/BCL2L11/NOTCH1/BAX	4
BP	GO:1904358	positive regulation of telomere maintenance via telomere lengthening	4/365	36/18862	0.00498393172942989	0.0109742947714918	0.00421774175096452	HNRNPA1/MAPK1/ATM/MAPK3	4
BP	GO:2000144	positive regulation of DNA-templated transcription, initiation	4/365	36/18862	0.00498393172942989	0.0109742947714918	0.00421774175096452	CTNNB1/MED12/SETX/JUN	4
BP	GO:0001523	retinoid metabolic process	7/365	108/18862	0.00503583378355719	0.0110839167464837	0.00425987267512628	LRP2/CYP3A5/CYP2D6/APOE/LPL/TTR/CYP1A1	7
BP	GO:0097061	dendritic spine organization	6/365	82/18862	0.00513551368641144	0.0112985618472793	0.00434236705149544	IGF1R/LRRK2/APOE/ADAM10/GRIN2B/RELN	6
BP	GO:0017157	regulation of exocytosis	10/365	197/18862	0.00515381464260429	0.011334061277055	0.00435601051836214	STXBP1/ATP13A2/GSK3B/SNCA/CFTR/LRRK2/NOTCH1/IL1RAPL1/IFNG/CNR1	10
BP	GO:0031102	neuron projection regeneration	5/365	58/18862	0.00522443829701265	0.0114749097971314	0.00441014271510532	SPP1/KLF4/BCL2/DAG1/MTR	5
BP	GO:0031638	zymogen activation	5/365	58/18862	0.00522443829701265	0.0114749097971314	0.00441014271510532	PLAT/FURIN/SERPINE1/GRIN2A/HP	5
BP	GO:0051965	positive regulation of synapse assembly	5/365	58/18862	0.00522443829701265	0.0114749097971314	0.00441014271510532	NLGN3/GHRL/IL1RAPL1/NTRK1/NRXN1	5
BP	GO:1903322	positive regulation of protein modification by small protein conjugation or removal	8/365	137/18862	0.00524348986809938	0.0115119236449799	0.0044243682170337	PINK1/STUB1/XIAP/HUWE1/HDAC4/BRCA1/LRRK2/CAV1	8
BP	GO:0007088	regulation of mitotic nuclear division	7/365	109/18862	0.00529444335068371	0.0116189167704312	0.00446548879759751	EDN1/RAD21/ATM/BMP4/IGF1/PDGFRB/AURKA	7
BP	GO:0072331	signal transduction by p53 class mediator	12/365	263/18862	0.00536566817554478	0.0117702880263208	0.00452366518880579	MIF/BCL2/NUPR1/EP300/RPL5/GADD45A/ATM/BRCA1/CDKN1A/BRCA2/BAX/AURKA	12
BP	GO:0043506	regulation of JUN kinase activity	6/365	83/18862	0.00544771795133278	0.011935268211501	0.00458707188869906	NPPA/EDN1/AGER/TF/TNFSF11/CD40LG	6
BP	GO:0045069	regulation of viral genome replication	6/365	83/18862	0.00544771795133278	0.011935268211501	0.00458707188869906	CCL5/BCL2/EIF2AK2/VAPB/PPARA/NOTCH1	6
BP	GO:0045652	regulation of megakaryocyte differentiation	6/365	83/18862	0.00544771795133278	0.011935268211501	0.00458707188869906	MEF2C/AGO1/EP300/KMT2A/KMT2D/KMT2C	6
BP	GO:0009185	ribonucleoside diphosphate metabolic process	8/365	138/18862	0.00547505434588284	0.0119901399357116	0.00460816069367193	NUPR1/EP300/P2RX7/HDAC4/PPARA/APP/IFNG/IGF1	8
BP	GO:0000096	sulfur amino acid metabolic process	4/365	37/18862	0.00550422020781155	0.0120144879892065	0.00461751836119575	CBS/MTR/MTHFR/NOX4	4
BP	GO:0051931	regulation of sensory perception	4/365	37/18862	0.00550422020781155	0.0120144879892065	0.00461751836119575	EDNRB/EDN1/MTOR/IL10	4
BP	GO:0090218	positive regulation of lipid kinase activity	4/365	37/18862	0.00550422020781155	0.0120144879892065	0.00461751836119575	SRC/KIT/PDGFRB/P2RY12	4
BP	GO:1901031	regulation of response to reactive oxygen species	4/365	37/18862	0.00550422020781155	0.0120144879892065	0.00461751836119575	PINK1/TXN/LRRK2/IL10	4
BP	GO:1902229	regulation of intrinsic apoptotic signaling pathway in response to DNA damage	4/365	37/18862	0.00550422020781155	0.0120144879892065	0.00461751836119575	MIF/BCL2/CXCL12/CLU	4
BP	GO:2000403	positive regulation of lymphocyte migration	4/365	37/18862	0.00550422020781155	0.0120144879892065	0.00461751836119575	CCL5/CXCL12/APP/ADAM10	4
BP	GO:0043112	receptor metabolic process	9/365	168/18862	0.00552589979236596	0.0120144879892065	0.00461751836119575	SORL1/SNCA/UBQLN2/FURIN/APOE/DRD4/VEGFA/GRIA1/CAV1	9
BP	GO:0003159	morphogenesis of an endothelium	3/365	19/18862	0.00553208178333735	0.0120144879892065	0.00461751836119575	CTNNB1/CXCR4/BMP4	3
BP	GO:0007620	copulation	3/365	19/18862	0.00553208178333735	0.0120144879892065	0.00461751836119575	EDNRB/CNR1/SLC6A4	3
BP	GO:0010002	cardioblast differentiation	3/365	19/18862	0.00553208178333735	0.0120144879892065	0.00461751836119575	GATA4/NRG1/NOTCH1	3
BP	GO:0021511	spinal cord patterning	3/365	19/18862	0.00553208178333735	0.0120144879892065	0.00461751836119575	GLI3/RELN/SHH	3
BP	GO:0032303	regulation of icosanoid secretion	3/365	19/18862	0.00553208178333735	0.0120144879892065	0.00461751836119575	EDN1/TNFSF11/PLA2G4A	3
BP	GO:0048643	positive regulation of skeletal muscle tissue development	3/365	19/18862	0.00553208178333735	0.0120144879892065	0.00461751836119575	BCL2/MEF2C/SHH	3
BP	GO:0060231	mesenchymal to epithelial transition	3/365	19/18862	0.00553208178333735	0.0120144879892065	0.00461751836119575	STAT1/BMP4/GDNF	3
BP	GO:0061154	endothelial tube morphogenesis	3/365	19/18862	0.00553208178333735	0.0120144879892065	0.00461751836119575	CTNNB1/CXCR4/BMP4	3
BP	GO:0070989	oxidative demethylation	3/365	19/18862	0.00553208178333735	0.0120144879892065	0.00461751836119575	CYP3A5/CYP2D6/TET1	3
BP	GO:0071731	response to nitric oxide	3/365	19/18862	0.00553208178333735	0.0120144879892065	0.00461751836119575	TXN/MTR/MMP3	3
BP	GO:0072087	renal vesicle development	3/365	19/18862	0.00553208178333735	0.0120144879892065	0.00461751836119575	STAT1/BMP4/GDNF	3
BP	GO:0097150	neuronal stem cell population maintenance	3/365	19/18862	0.00553208178333735	0.0120144879892065	0.00461751836119575	SOX2/NOTCH1/CDH2	3
BP	GO:1900221	regulation of amyloid-beta clearance	3/365	19/18862	0.00553208178333735	0.0120144879892065	0.00461751836119575	APOE/IFNG/CLU	3
BP	GO:0046324	regulation of glucose import	5/365	59/18862	0.00561958414931762	0.0121994622304141	0.00468860936032045	OCLN/LEP/TERT/IGF1/ADIPOQ	5
BP	GO:0031333	negative regulation of protein-containing complex assembly	8/365	139/18862	0.00571434146620355	0.0123948873742683	0.004763716946328	STXBP1/EP300/GSK3B/SORL1/SNCA/SRC/HMGB1/CLU	8
BP	GO:0048813	dendrite morphogenesis	8/365	139/18862	0.00571434146620355	0.0123948873742683	0.004763716946328	NEDD4L/GSK3B/CUX1/CDKL5/LRRK2/IL1RAPL1/ADAM10/RELN	8
BP	GO:0006605	protein targeting	17/365	441/18862	0.005732514082132	0.0124291543934875	0.00477688676185159	GABARAP/SORT1/RPS27A/HRAS/RPS6/PINK1/USP9X/RPL5/SCARB2/HSP90AA1/HUWE1/SORL1/LAMP2/LRRK2/ANK3/CLU/NOS2	17
BP	GO:0002718	regulation of cytokine production involved in immune response	6/365	84/18862	0.00577358427805868	0.0125026645061478	0.00480513884344234	IL18/IL1R1/B2M/IL6/NLRP3/IL10	6
BP	GO:0046330	positive regulation of JNK cascade	6/365	84/18862	0.00577358427805868	0.0125026645061478	0.00480513884344234	HRAS/GADD45A/HMGB1/AGER/APP/TNFSF11	6
BP	GO:0061053	somite development	6/365	84/18862	0.00577358427805868	0.0125026645061478	0.00480513884344234	EP300/PRKDC/MED12/ATM/NOTCH1/SHH	6
BP	GO:0070646	protein modification by small protein removal	13/365	300/18862	0.0058745876079893	0.0127161255335881	0.00488717814586546	RPS27A/NFKBIA/IKBKG/HCFC1/USP9X/EP300/BRCA1/CFTR/ADRB2/AR/NLRP3/MYC/UCHL1	13
BP	GO:0016331	morphogenesis of embryonic epithelium	8/365	140/18862	0.00596151350221889	0.0128989506699519	0.00495744318127991	LRP2/MED12/MTHFR/AR/FGFR2/BMP4/GDNF/SHH	8
BP	GO:0060998	regulation of dendritic spine development	5/365	60/18862	0.00603535225430046	0.0130371579442875	0.00501056027020361	MEF2C/MTOR/CDKL5/APOE/RELN	5
BP	GO:0071384	cellular response to corticosteroid stimulus	5/365	60/18862	0.00603535225430046	0.0130371579442875	0.00501056027020361	EDN1/EIF4E/ICAM1/BCL2L11/EGFR	5
BP	GO:1902110	positive regulation of mitochondrial membrane permeability involved in apoptotic process	5/365	60/18862	0.00603535225430046	0.0130371579442875	0.00501056027020361	BCL2/GSK3B/BCL2L11/HSPA1A/BAX	5
BP	GO:1903670	regulation of sprouting angiogenesis	5/365	60/18862	0.00603535225430046	0.0130371579442875	0.00501056027020361	KLF4/HMGB1/GHRL/VEGFA/IL10	5
BP	GO:0001914	regulation of T cell mediated cytotoxicity	4/365	38/18862	0.0060595587582358	0.0130463720858108	0.00501410153369357	PTPRC/AGER/B2M/HLA-DRB1	4
BP	GO:0007223	Wnt signaling pathway, calcium modulating pathway	4/365	38/18862	0.0060595587582358	0.0130463720858108	0.00501410153369357	AGO1/CTNNB1/AGO2/CAMK2A	4
BP	GO:0008210	estrogen metabolic process	4/365	38/18862	0.0060595587582358	0.0130463720858108	0.00501410153369357	CYP3A5/CYP2D6/CYP19A1/CYP1A1	4
BP	GO:0032733	positive regulation of interleukin-10 production	4/365	38/18862	0.0060595587582358	0.0130463720858108	0.00501410153369357	HMGB1/IL6/TLR2/CD40LG	4
BP	GO:0045923	positive regulation of fatty acid metabolic process	4/365	38/18862	0.0060595587582358	0.0130463720858108	0.00501410153369357	ABCD1/PPARA/PPARG/ADIPOQ	4
BP	GO:0046326	positive regulation of glucose import	4/365	38/18862	0.0060595587582358	0.0130463720858108	0.00501410153369357	OCLN/TERT/IGF1/ADIPOQ	4
BP	GO:0060612	adipose tissue development	4/365	38/18862	0.0060595587582358	0.0130463720858108	0.00501410153369357	XBP1/SORL1/LEP/GHRL	4
BP	GO:0071548	response to dexamethasone	4/365	38/18862	0.0060595587582358	0.0130463720858108	0.00501410153369357	EDN1/EIF4E/ICAM1/EGFR	4
BP	GO:0045921	positive regulation of exocytosis	6/365	85/18862	0.00611345080463298	0.0131515830297777	0.00505453716990228	STXBP1/ATP13A2/SNCA/CFTR/IFNG/CNR1	6
BP	GO:0046928	regulation of neurotransmitter secretion	6/365	85/18862	0.00611345080463298	0.0131515830297777	0.00505453716990228	STXBP1/MEF2C/GSK3B/LRRK2/CNR1/CAMK2A	6
BP	GO:1903828	negative regulation of cellular protein localization	7/365	112/18862	0.00613021975558325	0.0131822391950381	0.00506631922887151	NEDD4L/TXN/GSK3B/UBE2J1/LRRK2/ASTN2/ADIPOQ	7
BP	GO:0009150	purine ribonucleotide metabolic process	16/365	408/18862	0.00618552552808308	0.0132957045642656	0.0051099272816024	NPPA/ABCD1/NUPR1/PARP1/PINK1/EP300/RORA/P2RX7/HDAC4/PPARA/LRRK2/APP/ACSL4/IFNG/IGF1/XDH	16
BP	GO:0003215	cardiac right ventricle morphogenesis	3/365	20/18862	0.00641606968875298	0.0136789037682008	0.00525720191883672	GATA4/CHD7/NOTCH1	3
BP	GO:0006346	DNA methylation-dependent heterochromatin assembly	3/365	20/18862	0.00641606968875298	0.0136789037682008	0.00525720191883672	DNMT3A/DNMT1/TET1	3
BP	GO:0006525	arginine metabolic process	3/365	20/18862	0.00641606968875298	0.0136789037682008	0.00525720191883672	CLN3/NOS2/NOS1	3
BP	GO:0010847	regulation of chromatin assembly	3/365	20/18862	0.00641606968875298	0.0136789037682008	0.00525720191883672	PHF8/DNMT1/TET1	3
BP	GO:0015669	gas transport	3/365	20/18862	0.00641606968875298	0.0136789037682008	0.00525720191883672	HBA1/HBB/MYC	3
BP	GO:0021904	dorsal/ventral neural tube patterning	3/365	20/18862	0.00641606968875298	0.0136789037682008	0.00525720191883672	GLI3/BMP4/SHH	3
BP	GO:0030220	platelet formation	3/365	20/18862	0.00641606968875298	0.0136789037682008	0.00525720191883672	MEF2C/EP300/PRKDC	3
BP	GO:0031293	membrane protein intracellular domain proteolysis	3/365	20/18862	0.00641606968875298	0.0136789037682008	0.00525720191883672	PSEN2/NGFR/ADAM10	3
BP	GO:0036120	cellular response to platelet-derived growth factor stimulus	3/365	20/18862	0.00641606968875298	0.0136789037682008	0.00525720191883672	ATP7A/SRC/PDGFRB	3
BP	GO:0043586	tongue development	3/365	20/18862	0.00641606968875298	0.0136789037682008	0.00525720191883672	GLI3/EGFR/KIT	3
BP	GO:0043931	ossification involved in bone maturation	3/365	20/18862	0.00641606968875298	0.0136789037682008	0.00525720191883672	LEP/IGF1/BMP2	3
BP	GO:0046885	regulation of hormone biosynthetic process	3/365	20/18862	0.00641606968875298	0.0136789037682008	0.00525720191883672	ATP1A1/EGR1/BMP2	3
BP	GO:0046931	pore complex assembly	3/365	20/18862	0.00641606968875298	0.0136789037682008	0.00525720191883672	RTN4/P2RX7/ADAM10	3
BP	GO:0050849	negative regulation of calcium-mediated signaling	3/365	20/18862	0.00641606968875298	0.0136789037682008	0.00525720191883672	MTOR/GSK3B/ITPR1	3
BP	GO:0051412	response to corticosterone	3/365	20/18862	0.00641606968875298	0.0136789037682008	0.00525720191883672	FOS/CCND1/CDKN1A	3
BP	GO:0051570	regulation of histone H3-K9 methylation	3/365	20/18862	0.00641606968875298	0.0136789037682008	0.00525720191883672	MECP2/DNMT1/BRCA1	3
BP	GO:0060445	branching involved in salivary gland morphogenesis	3/365	20/18862	0.00641606968875298	0.0136789037682008	0.00525720191883672	DAG1/FGFR2/SHH	3
BP	GO:0097062	dendritic spine maintenance	3/365	20/18862	0.00641606968875298	0.0136789037682008	0.00525720191883672	IGF1R/APOE/GRIN2B	3
BP	GO:1902004	positive regulation of amyloid-beta formation	3/365	20/18862	0.00641606968875298	0.0136789037682008	0.00525720191883672	SP1/IFNG/CLU	3
BP	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	3/365	20/18862	0.00641606968875298	0.0136789037682008	0.00525720191883672	PINK1/HSPB1/SOD2	3
BP	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	6/365	86/18862	0.00646765491294893	0.0137720528130084	0.00529300181518796	RPS27A/STUB1/PPARA/HSPA1A/FBN1/CAV1	6
BP	GO:0055072	iron ion homeostasis	6/365	86/18862	0.00646765491294893	0.0137720528130084	0.00529300181518796	ATP13A2/TF/B2M/CP/IFNG/MYC	6
BP	GO:0060021	roof of mouth development	6/365	86/18862	0.00646765491294893	0.0137720528130084	0.00529300181518796	COL2A1/GLI3/CHD7/DLX5/SATB2/SHH	6
BP	GO:0050852	T cell receptor signaling pathway	10/365	204/18862	0.00654950907235064	0.0139406793349668	0.00535780990871859	PIK3R2/PTPRC/CD4/IKBKG/HRAS/MAPK1/CTLA4/HLA-DQA1/HLA-DRB1/HLA-DQB1	10
BP	GO:0016202	regulation of striated muscle tissue development	4/365	39/18862	0.00665093480544961	0.0141106577915376	0.00542313759017525	BCL2/MEF2C/BMP4/SHH	4
BP	GO:0016572	histone phosphorylation	4/365	39/18862	0.00665093480544961	0.0141106577915376	0.00542313759017525	ATM/MAPK3/PRKCA/AURKA	4
BP	GO:0032660	regulation of interleukin-17 production	4/365	39/18862	0.00665093480544961	0.0141106577915376	0.00542313759017525	IL18/DDIT3/IL6/IFNG	4
BP	GO:0060416	response to growth hormone	4/365	39/18862	0.00665093480544961	0.0141106577915376	0.00542313759017525	GHRL/PRL/GHR/GDF15	4
BP	GO:0071470	cellular response to osmotic stress	4/365	39/18862	0.00665093480544961	0.0141106577915376	0.00542313759017525	CLN3/SLC2A1/SLC2A4/TRPV4	4
BP	GO:1901381	positive regulation of potassium ion transmembrane transport	4/365	39/18862	0.00665093480544961	0.0141106577915376	0.00542313759017525	NPPA/ANK2/KCNQ1/KCNH2	4
BP	GO:1903539	protein localization to postsynaptic membrane	4/365	39/18862	0.00665093480544961	0.0141106577915376	0.00542313759017525	HRAS/DAG1/ADAM10/GRIN2A	4
BP	GO:2000785	regulation of autophagosome assembly	4/365	39/18862	0.00665093480544961	0.0141106577915376	0.00542313759017525	NUPR1/PINK1/UBQLN2/LRRK2	4
BP	GO:0031109	microtubule polymerization or depolymerization	7/365	114/18862	0.00673963176076441	0.0142930440177637	0.00549323393961477	OCLN/MECP2/SNCA/SPAST/HSPA1B/HSPA1A/TRPV4	7
BP	GO:0051898	negative regulation of protein kinase B signaling	5/365	62/18862	0.00693093399999031	0.0146809018842369	0.00564229903681931	KLF4/DAG1/PPARA/DDIT3/XDH	5
BP	GO:0061912	selective autophagy	5/365	62/18862	0.00693093399999031	0.0146809018842369	0.00564229903681931	PINK1/HTT/HUWE1/MAPK3/ADRB2	5
BP	GO:2000756	regulation of peptidyl-lysine acetylation	5/365	62/18862	0.00693093399999031	0.0146809018842369	0.00564229903681931	KMT2A/SNCA/MAPK3/BRCA1/NOS1	5
BP	GO:0048593	camera-type eye morphogenesis	7/365	115/18862	0.00706068885777304	0.0149496947741036	0.00574560398876013	GLI3/NF1/ATF4/MFSD2A/BMP4/BAX/VEGFA	7
BP	GO:0002532	production of molecular mediator involved in inflammatory response	6/365	88/18862	0.00722042015489867	0.0152693652891877	0.0058684626968682	ABCD1/PPARA/LEP/IL6/SERPINE1/NOS2	6
BP	GO:0051453	regulation of intracellular pH	6/365	88/18862	0.00722042015489867	0.0152693652891877	0.0058684626968682	BCL2/CLN3/SLC9A6/CFTR/LRRK2/FASLG	6
BP	GO:0070098	chemokine-mediated signaling pathway	6/365	88/18862	0.00722042015489867	0.0152693652891877	0.0058684626968682	CCR5/CCL5/EDN1/CXCR4/CXCL12/CCL2	6
BP	GO:0002363	alpha-beta T cell lineage commitment	3/365	21/18862	0.00737940788663715	0.015468090059535	0.00594483842563227	BCL2/MTOR/IL6	3
BP	GO:0003177	pulmonary valve development	3/365	21/18862	0.00737940788663715	0.015468090059535	0.00594483842563227	TNFRSF1A/NOTCH1/BMP4	3
BP	GO:0006662	glycerol ether metabolic process	3/365	21/18862	0.00737940788663715	0.015468090059535	0.00594483842563227	TXN/PLA2G6/PLA2G4A	3
BP	GO:0022010	central nervous system myelination	3/365	21/18862	0.00737940788663715	0.015468090059535	0.00594483842563227	PLP1/TLR2/CLU	3
BP	GO:0032291	axon ensheathment in central nervous system	3/365	21/18862	0.00737940788663715	0.015468090059535	0.00594483842563227	PLP1/TLR2/CLU	3
BP	GO:0036119	response to platelet-derived growth factor	3/365	21/18862	0.00737940788663715	0.015468090059535	0.00594483842563227	ATP7A/SRC/PDGFRB	3
BP	GO:0036344	platelet morphogenesis	3/365	21/18862	0.00737940788663715	0.015468090059535	0.00594483842563227	MEF2C/EP300/PRKDC	3
BP	GO:0043984	histone H4-K16 acetylation	3/365	21/18862	0.00737940788663715	0.015468090059535	0.00594483842563227	HCFC1/KMT2A/BRCA1	3
BP	GO:0048169	regulation of long-term neuronal synaptic plasticity	3/365	21/18862	0.00737940788663715	0.015468090059535	0.00594483842563227	HRAS/KIT/APP	3
BP	GO:0048745	smooth muscle tissue development	3/365	21/18862	0.00737940788663715	0.015468090059535	0.00594483842563227	NF1/BMP4/SHH	3
BP	GO:0051152	positive regulation of smooth muscle cell differentiation	3/365	21/18862	0.00737940788663715	0.015468090059535	0.00594483842563227	KIT/SOD2/SHH	3
BP	GO:0060965	negative regulation of gene silencing by miRNA	3/365	21/18862	0.00737940788663715	0.015468090059535	0.00594483842563227	PPARG/IL6/TERT	3
BP	GO:0072574	hepatocyte proliferation	3/365	21/18862	0.00737940788663715	0.015468090059535	0.00594483842563227	XBP1/CEBPB/IL6	3
BP	GO:0072575	epithelial cell proliferation involved in liver morphogenesis	3/365	21/18862	0.00737940788663715	0.015468090059535	0.00594483842563227	XBP1/CEBPB/IL6	3
BP	GO:0099633	protein localization to postsynaptic specialization membrane	3/365	21/18862	0.00737940788663715	0.015468090059535	0.00594483842563227	HRAS/DAG1/ADAM10	3
BP	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	3/365	21/18862	0.00737940788663715	0.015468090059535	0.00594483842563227	HRAS/DAG1/ADAM10	3
BP	GO:1902307	positive regulation of sodium ion transmembrane transport	3/365	21/18862	0.00737940788663715	0.015468090059535	0.00594483842563227	ANK3/DRD4/NOS1	3
BP	GO:1904886	beta-catenin destruction complex disassembly	3/365	21/18862	0.00737940788663715	0.015468090059535	0.00594483842563227	CTNNB1/GSK3B/CAV1	3
BP	GO:1905209	positive regulation of cardiocyte differentiation	3/365	21/18862	0.00737940788663715	0.015468090059535	0.00594483842563227	MEF2C/GATA4/BMP4	3
BP	GO:2000047	regulation of cell-cell adhesion mediated by cadherin	3/365	21/18862	0.00737940788663715	0.015468090059535	0.00594483842563227	NOTCH1/EPCAM/VEGFA	3
BP	GO:2000479	regulation of cAMP-dependent protein kinase activity	3/365	21/18862	0.00737940788663715	0.015468090059535	0.00594483842563227	HTT/ADRB2/ADIPOQ	3
BP	GO:2001169	regulation of ATP biosynthetic process	3/365	21/18862	0.00737940788663715	0.015468090059535	0.00594483842563227	PARP1/PINK1/PPARA	3
BP	GO:2000401	regulation of lymphocyte migration	5/365	63/18862	0.00741182165009105	0.0155298136575567	0.00596856060567359	CCL5/CXCL12/CCL2/APP/ADAM10	5
BP	GO:0019935	cyclic-nucleotide-mediated signaling	6/365	89/18862	0.00761965008094361	0.0159588829626486	0.00613346446144068	NPPA/EDNRB/NDUFS4/APOE/AHR/HTR2C	6
BP	GO:0043010	camera-type eye development	13/365	310/18862	0.00765041380403487	0.0160169063401274	0.00615576453874133	KLF4/GLI3/NF1/ATF4/MFSD2A/CHD7/BMP4/BAX/PDGFRB/CYP1A1/VEGFA/FBN1/SHH	13
BP	GO:0002478	antigen processing and presentation of exogenous peptide antigen	9/365	177/18862	0.007694625312225	0.016103026343137	0.00618886296919631	CYBB/IKBKG/DYNC1H1/HLA-DQA1/B2M/CANX/CTSD/HLA-DRB1/HLA-DQB1	9
BP	GO:0000075	cell cycle checkpoint	10/365	209/18862	0.00771430996533558	0.0161313217573178	0.00619973772263023	EP300/CLOCK/PRKDC/GADD45A/ATM/BRCA1/CCND1/CDKN1A/BAX/AURKA	10
BP	GO:0051650	establishment of vesicle localization	10/365	209/18862	0.00771430996533558	0.0161313217573178	0.00619973772263023	IKBKG/PINK1/HTT/TRAPPC9/CLN3/DYNC1H1/SERPINA1/LRRK2/SLC2A4/GRIA1	10
BP	GO:0044839	cell cycle G2/M phase transition	12/365	276/18862	0.00776919467802353	0.0162396026137281	0.00624135321578232	MECP2/HSP90AA1/BRD4/DYNC1H1/RAD21/ATM/BRCA1/ALMS1/CCND1/CDKN1A/APP/AURKA	12
BP	GO:1902305	regulation of sodium ion transmembrane transport	5/365	64/18862	0.00791547853857782	0.0165159836391565	0.00634757450966919	NEDD4L/ANK3/DRD4/SCN5A/NOS1	5
BP	GO:1905268	negative regulation of chromatin organization	5/365	64/18862	0.00791547853857782	0.0165159836391565	0.00634757450966919	PHF8/SNCA/DNMT1/BRCA1/TET1	5
BP	GO:0007043	cell-cell junction assembly	8/365	147/18862	0.00792623793189256	0.0165159836391565	0.00634757450966919	OCLN/CTNNB1/GJA1/PRKCA/AGT/CDH2/CAV1/TRPV4	8
BP	GO:0007605	sensory perception of sound	8/365	147/18862	0.00792623793189256	0.0165159836391565	0.00634757450966919	LRP2/COL2A1/ICAM1/CHD7/DDIT3/KIT/KCNQ1/BIRC5	8
BP	GO:0090263	positive regulation of canonical Wnt signaling pathway	8/365	147/18862	0.00792623793189256	0.0165159836391565	0.00634757450966919	ARNTL/XIAP/SRC/EGFR/LRRK2/FGFR2/DLX5/CAV1	8
BP	GO:0001709	cell fate determination	4/365	41/18862	0.00794559549166911	0.0165159836391565	0.00634757450966919	KLF4/MEF2C/BMP4/FOXG1	4
BP	GO:0010591	regulation of lamellipodium assembly	4/365	41/18862	0.00794559549166911	0.0165159836391565	0.00634757450966919	OCLN/ATP7A/MTOR/HDAC4	4
BP	GO:0010907	positive regulation of glucose metabolic process	4/365	41/18862	0.00794559549166911	0.0165159836391565	0.00634757450966919	PPARA/SRC/HMGB1/IGF1	4
BP	GO:0021983	pituitary gland development	4/365	41/18862	0.00794559549166911	0.0165159836391565	0.00634757450966919	ETS1/SOX2/BMP4/BMP2	4
BP	GO:0032689	negative regulation of interferon-gamma production	4/365	41/18862	0.00794559549166911	0.0165159836391565	0.00634757450966919	DDIT3/HMGB1/HLA-DRB1/IL10	4
BP	GO:0046636	negative regulation of alpha-beta T cell activation	4/365	41/18862	0.00794559549166911	0.0165159836391565	0.00634757450966919	GLI3/HMGB1/SOCS1/SHH	4
BP	GO:0090317	negative regulation of intracellular protein transport	4/365	41/18862	0.00794559549166911	0.0165159836391565	0.00634757450966919	TXN/UBE2J1/LRRK2/ADIPOQ	4
BP	GO:1901186	positive regulation of ERBB signaling pathway	4/365	41/18862	0.00794559549166911	0.0165159836391565	0.00634757450966919	MMP9/RTN4/FASLG/AGT	4
BP	GO:1901861	regulation of muscle tissue development	4/365	41/18862	0.00794559549166911	0.0165159836391565	0.00634757450966919	BCL2/MEF2C/BMP4/SHH	4
BP	GO:0015718	monocarboxylic acid transport	9/365	178/18862	0.00797072415494023	0.0165616396295979	0.00636512143920552	EDN1/STXBP1/GJA1/SLC6A8/LEP/DRD4/TNFSF11/PLA2G4A/NOS2	9
BP	GO:0031398	positive regulation of protein ubiquitination	7/365	118/18862	0.00809199622149649	0.0167936194382683	0.00645427804970149	PINK1/STUB1/XIAP/HUWE1/BRCA1/LRRK2/CAV1	7
BP	GO:0046916	cellular transition metal ion homeostasis	7/365	118/18862	0.00809199622149649	0.0167936194382683	0.00645427804970149	ATP7A/ATP13A2/TF/CP/APP/IFNG/MYC	7
BP	GO:0072676	lymphocyte migration	7/365	118/18862	0.00809199622149649	0.0167936194382683	0.00645427804970149	CCL5/ICAM1/PIK3CG/CXCL12/CCL2/APP/ADAM10	7
BP	GO:1903900	regulation of viral life cycle	8/365	148/18862	0.00824239059838011	0.017098958538217	0.00657162877672962	CCL5/CD4/BCL2/EIF2AK2/VAPB/PPARA/NOTCH1/HLA-DRB1	8
BP	GO:0003081	regulation of systemic arterial blood pressure by renin-angiotensin	3/365	22/18862	0.00842369276852336	0.0173581133663194	0.00667122954026032	AGTR1/AGT/MME	3
BP	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	3/365	22/18862	0.00842369276852336	0.0173581133663194	0.00667122954026032	ANK2/RYR2/CASQ2	3
BP	GO:0030878	thyroid gland development	3/365	22/18862	0.00842369276852336	0.0173581133663194	0.00667122954026032	MAPK1/MAPK3/SHH	3
BP	GO:0042359	vitamin D metabolic process	3/365	22/18862	0.00842369276852336	0.0173581133663194	0.00667122954026032	LRP2/IFNG/CYP1A1	3
BP	GO:0044346	fibroblast apoptotic process	3/365	22/18862	0.00842369276852336	0.0173581133663194	0.00667122954026032	PIK3CG/BCL2L11/MYC	3
BP	GO:0045061	thymic T cell selection	3/365	22/18862	0.00842369276852336	0.0173581133663194	0.00667122954026032	PTPRC/GLI3/SHH	3
BP	GO:0045844	positive regulation of striated muscle tissue development	3/365	22/18862	0.00842369276852336	0.0173581133663194	0.00667122954026032	BCL2/MEF2C/SHH	3
BP	GO:0048636	positive regulation of muscle organ development	3/365	22/18862	0.00842369276852336	0.0173581133663194	0.00667122954026032	BCL2/MEF2C/SHH	3
BP	GO:0050765	negative regulation of phagocytosis	3/365	22/18862	0.00842369276852336	0.0173581133663194	0.00667122954026032	HMGB1/TLR2/ADIPOQ	3
BP	GO:0051151	negative regulation of smooth muscle cell differentiation	3/365	22/18862	0.00842369276852336	0.0173581133663194	0.00667122954026032	MECP2/DNMT1/SHH	3
BP	GO:0051590	positive regulation of neurotransmitter transport	3/365	22/18862	0.00842369276852336	0.0173581133663194	0.00667122954026032	STXBP1/DRD4/CNR1	3
BP	GO:0071404	cellular response to low-density lipoprotein particle stimulus	3/365	22/18862	0.00842369276852336	0.0173581133663194	0.00667122954026032	PPARG/ABCA1/LPL	3
BP	GO:0072576	liver morphogenesis	3/365	22/18862	0.00842369276852336	0.0173581133663194	0.00667122954026032	XBP1/CEBPB/IL6	3
BP	GO:0086012	membrane depolarization during cardiac muscle cell action potential	3/365	22/18862	0.00842369276852336	0.0173581133663194	0.00667122954026032	ANK2/ANK3/SCN5A	3
BP	GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell	3/365	22/18862	0.00842369276852336	0.0173581133663194	0.00667122954026032	ICAM1/ETS1/IL6	3
BP	GO:2000725	regulation of cardiac muscle cell differentiation	3/365	22/18862	0.00842369276852336	0.0173581133663194	0.00667122954026032	MEF2C/BMP4/BMP2	3
BP	GO:2000773	negative regulation of cellular senescence	3/365	22/18862	0.00842369276852336	0.0173581133663194	0.00667122954026032	AKT3/PRKDC/TERT	3
BP	GO:0001756	somitogenesis	5/365	65/18862	0.0084424239985867	0.0173761884422347	0.00667817631943175	EP300/PRKDC/MED12/ATM/NOTCH1	5
BP	GO:0007585	respiratory gaseous exchange by respiratory system	5/365	65/18862	0.0084424239985867	0.0173761884422347	0.00667817631943175	EDN1/MECP2/ELN/NLGN3/SFTPB	5
BP	GO:0035773	insulin secretion involved in cellular response to glucose stimulus	5/365	65/18862	0.0084424239985867	0.0173761884422347	0.00667817631943175	CFTR/UCP2/PLA2G6/GHRL/HLA-DRB1	5
BP	GO:0048524	positive regulation of viral process	6/365	91/18862	0.0084654639895761	0.0174099169042991	0.00669113915172368	CCL5/CD4/VAPB/PPARA/NOTCH1/HLA-DRB1	6
BP	GO:1903321	negative regulation of protein modification by small protein conjugation or removal	6/365	91/18862	0.0084654639895761	0.0174099169042991	0.00669113915172368	CTNNB1/RPL5/MTOR/HSPA1B/HSPA1A/CAV1	6
BP	GO:0003197	endocardial cushion development	4/365	42/18862	0.0086506987528359	0.0177559832440561	0.00682414254558076	GATA4/NOTCH1/BMP4/BMP2	4
BP	GO:0019432	triglyceride biosynthetic process	4/365	42/18862	0.0086506987528359	0.0177559832440561	0.00682414254558076	MFSD2A/ACSL4/LPL/C3	4
BP	GO:0032965	regulation of collagen biosynthetic process	4/365	42/18862	0.0086506987528359	0.0177559832440561	0.00682414254558076	PPARG/IL6/BMP4/PDGFRB	4
BP	GO:0060999	positive regulation of dendritic spine development	4/365	42/18862	0.0086506987528359	0.0177559832440561	0.00682414254558076	MTOR/CDKL5/APOE/RELN	4
BP	GO:1902116	negative regulation of organelle assembly	4/365	42/18862	0.0086506987528359	0.0177559832440561	0.00682414254558076	NUPR1/PINK1/BRCA1/LRRK2	4
BP	GO:0006090	pyruvate metabolic process	8/365	150/18862	0.00890295628960497	0.018259433079856	0.00701763300999633	NUPR1/EP300/P2RX7/HDAC4/PPARA/APP/IFNG/IGF1	8
BP	GO:0050871	positive regulation of B cell activation	8/365	150/18862	0.00890295628960497	0.018259433079856	0.00701763300999633	XBP1/PTPRC/MIF/BCL2/MEF2C/CDKN1A/IL6/IL10	8
BP	GO:0001824	blastocyst development	6/365	92/18862	0.00891270575847192	0.0182651143069076	0.00701981647135138	KLF4/RTN4/FURIN/BRCA2/TET1/IGF1	6
BP	GO:0032088	negative regulation of NF-kappaB transcription factor activity	6/365	92/18862	0.00891270575847192	0.0182651143069076	0.00701981647135138	KLF4/NFKBIA/DDIT3/NLRP3/CDKN2A/IL10	6
BP	GO:0009259	ribonucleotide metabolic process	16/365	425/18862	0.00897240281961703	0.0183802568915364	0.00706406912690829	NPPA/ABCD1/NUPR1/PARP1/PINK1/EP300/RORA/P2RX7/HDAC4/PPARA/LRRK2/APP/ACSL4/IFNG/IGF1/XDH	16
BP	GO:0034332	adherens junction organization	5/365	66/18862	0.00899316942971318	0.0184155902954299	0.00707764878518322	CTNNB1/SRC/CDH2/VEGFA/ADAM10	5
BP	GO:0060964	regulation of gene silencing by miRNA	7/365	121/18862	0.00923027560565095	0.018886341876457	0.0072585723560343	AGO1/AGO2/PPARG/EGFR/IL6/BMP4/TERT	7
BP	GO:1904375	regulation of protein localization to cell periphery	7/365	121/18862	0.00923027560565095	0.018886341876457	0.0072585723560343	HRAS/DAG1/CLN3/EGFR/AR/IFNG/ADAM10	7
BP	GO:0002042	cell migration involved in sprouting angiogenesis	6/365	93/18862	0.00937660539965587	0.019134598212686	0.00735398451107998	KLF4/AKT3/KDR/NOTCH1/VEGFA/NR4A1	6
BP	GO:0032620	interleukin-17 production	4/365	43/18862	0.00939547524008465	0.019134598212686	0.00735398451107998	IL18/DDIT3/IL6/IFNG	4
BP	GO:0045840	positive regulation of mitotic nuclear division	4/365	43/18862	0.00939547524008465	0.019134598212686	0.00735398451107998	EDN1/IGF1/PDGFRB/AURKA	4
BP	GO:0046006	regulation of activated T cell proliferation	4/365	43/18862	0.00939547524008465	0.019134598212686	0.00735398451107998	IL18/HMGB1/AGER/IGF1	4
BP	GO:0048634	regulation of muscle organ development	4/365	43/18862	0.00939547524008465	0.019134598212686	0.00735398451107998	BCL2/MEF2C/BMP4/SHH	4
BP	GO:0061383	trabecula morphogenesis	4/365	43/18862	0.00939547524008465	0.019134598212686	0.00735398451107998	CHD7/NRG1/NOTCH1/MMP2	4
BP	GO:0070266	necroptotic process	4/365	43/18862	0.00939547524008465	0.019134598212686	0.00735398451107998	CD14/FAS/FASLG/CAV1	4
BP	GO:0097178	ruffle assembly	4/365	43/18862	0.00939547524008465	0.019134598212686	0.00735398451107998	HRAS/ICAM1/CAV1/P2RY12	4
BP	GO:0098927	vesicle-mediated transport between endosomal compartments	4/365	43/18862	0.00939547524008465	0.019134598212686	0.00735398451107998	SORL1/MAPK1/MAPK3/SRC	4
BP	GO:1904738	vascular associated smooth muscle cell migration	4/365	43/18862	0.00939547524008465	0.019134598212686	0.00735398451107998	MEF2C/ATP7A/TERT/ADIPOQ	4
BP	GO:1904752	regulation of vascular associated smooth muscle cell migration	4/365	43/18862	0.00939547524008465	0.019134598212686	0.00735398451107998	MEF2C/ATP7A/TERT/ADIPOQ	4
BP	GO:2000404	regulation of T cell migration	4/365	43/18862	0.00939547524008465	0.019134598212686	0.00735398451107998	CCL5/CXCL12/APP/ADAM10	4
BP	GO:0002438	acute inflammatory response to antigenic stimulus	3/365	23/18862	0.00955033425749589	0.0193072419867646	0.00742033655183861	ICAM1/CNR1/C3	3
BP	GO:0003181	atrioventricular valve morphogenesis	3/365	23/18862	0.00955033425749589	0.0193072419867646	0.00742033655183861	GATA4/NOTCH1/BMP2	3
BP	GO:0006359	regulation of transcription by RNA polymerase III	3/365	23/18862	0.00955033425749589	0.0193072419867646	0.00742033655183861	MTOR/BRCA1/AR	3
BP	GO:0010640	regulation of platelet-derived growth factor receptor signaling pathway	3/365	23/18862	0.00955033425749589	0.0193072419867646	0.00742033655183861	SNCA/SRC/ADIPOQ	3
BP	GO:0021544	subpallium development	3/365	23/18862	0.00955033425749589	0.0193072419867646	0.00742033655183861	GLI3/LRRK2/FOXP2	3
BP	GO:0045943	positive regulation of transcription by RNA polymerase I	3/365	23/18862	0.00955033425749589	0.0193072419867646	0.00742033655183861	MTOR/ATF4/PHF8	3
BP	GO:0046628	positive regulation of insulin receptor signaling pathway	3/365	23/18862	0.00955033425749589	0.0193072419867646	0.00742033655183861	SORL1/SRC/LEP	3
BP	GO:0048668	collateral sprouting	3/365	23/18862	0.00955033425749589	0.0193072419867646	0.00742033655183861	SPP1/NGF/APP	3
BP	GO:0050951	sensory perception of temperature stimulus	3/365	23/18862	0.00955033425749589	0.0193072419867646	0.00742033655183861	CXCR4/CXCL12/NTRK1	3
BP	GO:0051349	positive regulation of lyase activity	3/365	23/18862	0.00955033425749589	0.0193072419867646	0.00742033655183861	NF1/NOS2/NOS1	3
BP	GO:0060149	negative regulation of posttranscriptional gene silencing	3/365	23/18862	0.00955033425749589	0.0193072419867646	0.00742033655183861	PPARG/IL6/TERT	3
BP	GO:0060384	innervation	3/365	23/18862	0.00955033425749589	0.0193072419867646	0.00742033655183861	CHD7/VCAM1/NTRK1	3
BP	GO:0060967	negative regulation of gene silencing by RNA	3/365	23/18862	0.00955033425749589	0.0193072419867646	0.00742033655183861	PPARG/IL6/TERT	3
BP	GO:0070977	bone maturation	3/365	23/18862	0.00955033425749589	0.0193072419867646	0.00742033655183861	LEP/IGF1/BMP2	3
BP	GO:1900273	positive regulation of long-term synaptic potentiation	3/365	23/18862	0.00955033425749589	0.0193072419867646	0.00742033655183861	APP/MME/RELN	3
BP	GO:1901863	positive regulation of muscle tissue development	3/365	23/18862	0.00955033425749589	0.0193072419867646	0.00742033655183861	BCL2/MEF2C/SHH	3
BP	GO:1901984	negative regulation of protein acetylation	3/365	23/18862	0.00955033425749589	0.0193072419867646	0.00742033655183861	GSK3B/SNCA/BRCA1	3
BP	GO:1903055	positive regulation of extracellular matrix organization	3/365	23/18862	0.00955033425749589	0.0193072419867646	0.00742033655183861	DAG1/IL6/BMP2	3
BP	GO:2000353	positive regulation of endothelial cell apoptotic process	3/365	23/18862	0.00955033425749589	0.0193072419867646	0.00742033655183861	FASLG/CCL2/CD40LG	3
BP	GO:0036498	IRE1-mediated unfolded protein response	5/365	67/18862	0.00956821784659007	0.0193359274938426	0.0074313612293573	XBP1/DNAJC3/VAPB/BCL2L11/BAX	5
BP	GO:0051056	regulation of small GTPase mediated signal transduction	13/365	319/18862	0.00958894438636017	0.0193703338163679	0.00744458458320676	PIK3R2/HRAS/NGF/SRC/PIK3CG/APOE/NOTCH1/KITLG/ABCA1/IGF1/PDGFRB/NTRK1/RELN	13
BP	GO:0046942	carboxylic acid transport	12/365	284/18862	0.0096235085231287	0.019432655713756	0.0074685367071552	LRP2/EDN1/STXBP1/CLN3/GJA1/SLC6A8/LEP/DRD4/TNFSF11/PLA2G4A/NOS2/SLC6A1	12
BP	GO:0031929	TOR signaling	7/365	122/18862	0.00963452845698431	0.0194474053003686	0.0074742054037376	AKT3/ARNTL/RPS6/PINK1/MTOR/ATM/LEP	7
BP	GO:0006476	protein deacetylation	6/365	94/18862	0.00985748567894879	0.0198744530214245	0.00763833230576237	PINK1/EP300/HDAC4/LRRK2/IFNG/VEGFA	6
BP	GO:0045666	positive regulation of neuron differentiation	6/365	94/18862	0.00985748567894879	0.0198744530214245	0.00763833230576237	MEF2C/NGF/CXCL12/BMP4/FOXG1/BMP2	6
BP	GO:0097194	execution phase of apoptosis	6/365	94/18862	0.00985748567894879	0.0198744530214245	0.00763833230576237	CASP4/DICER1/HMGB1/IL6/FASLG/BAX	6
BP	GO:1990266	neutrophil migration	7/365	123/18862	0.0100515688377905	0.0202579558324972	0.00778572362808	CCL5/EDN1/PIK3CG/IL1R1/PPIB/CCL2/THBS4	7
BP	GO:0019884	antigen processing and presentation of exogenous antigen	9/365	185/18862	0.0101200554051562	0.0203881331757458	0.00783575458014403	CYBB/IKBKG/DYNC1H1/HLA-DQA1/B2M/CANX/CTSD/HLA-DRB1/HLA-DQB1	9
BP	GO:0044282	small molecule catabolic process	16/365	431/18862	0.0101664785761902	0.0204396063868908	0.00785553723736466	CBS/CEL/ABCD1/MTOR/MFSD2A/PPARA/ALDH2/LEP/ALDH3A2/APOE/ADIPOQ/CNR1/CYP1A1/NOS2/XDH/NOS1	16
BP	GO:0051656	establishment of organelle localization	16/365	431/18862	0.0101664785761902	0.0204396063868908	0.00785553723736466	STXBP1/IKBKG/PINK1/HTT/TRAPPC9/CLN3/DYNC1H1/GJA1/ATM/PIK3CG/SPAST/SERPINA1/LRRK2/KIT/SLC2A4/GRIA1	16
BP	GO:0043507	positive regulation of JUN kinase activity	5/365	68/18862	0.0101680634462417	0.0204396063868908	0.00785553723736466	EDN1/AGER/TF/TNFSF11/CD40LG	5
BP	GO:0043967	histone H4 acetylation	5/365	68/18862	0.0101680634462417	0.0204396063868908	0.00785553723736466	HCFC1/EP300/KMT2A/BRCA1/BRCA2	5
BP	GO:1900015	regulation of cytokine production involved in inflammatory response	5/365	68/18862	0.0101680634462417	0.0204396063868908	0.00785553723736466	ABCD1/PPARA/LEP/IL6/NOS2	5
BP	GO:0002639	positive regulation of immunoglobulin production	4/365	44/18862	0.0101807515954574	0.0204396063868908	0.00785553723736466	XBP1/PTPRC/IL6/IL10	4
BP	GO:0035987	endodermal cell differentiation	4/365	44/18862	0.0101807515954574	0.0204396063868908	0.00785553723736466	MMP9/SOX2/MMP2/FN1	4
BP	GO:0062237	protein localization to postsynapse	4/365	44/18862	0.0101807515954574	0.0204396063868908	0.00785553723736466	HRAS/DAG1/ADAM10/GRIN2A	4
BP	GO:1901028	regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	4/365	44/18862	0.0101807515954574	0.0204396063868908	0.00785553723736466	BCL2/GSK3B/HSPA1A/BAX	4
BP	GO:0035282	segmentation	6/365	95/18862	0.010355666514953	0.0207828061883681	0.00798743893690474	EP300/PRKDC/MED12/ATM/NOTCH1/BMP4	6
BP	GO:0006997	nucleus organization	7/365	124/18862	0.0104816199567697	0.0210194631623496	0.00807839311852664	TARDBP/RTN4/ETS1/SPAST/DMPK/PRKCA/AFF2	7
BP	GO:0060147	regulation of posttranscriptional gene silencing	7/365	124/18862	0.0104816199567697	0.0210194631623496	0.00807839311852664	AGO1/AGO2/PPARG/EGFR/IL6/BMP4/TERT	7
BP	GO:0031589	cell-substrate adhesion	14/365	359/18862	0.0105530079209717	0.0211545168358353	0.00813029818661006	L1CAM/BCL2/DAG1/NF1/GSK3B/SRC/BCL2L11/VCAM1/KDR/NOTCH1/SERPINE1/VEGFA/FN1/CDKN2A	14
BP	GO:0050851	antigen receptor-mediated signaling pathway	13/365	323/18862	0.0105651780751242	0.0211708047646249	0.00813655811298557	PIK3R2/PTPRC/CD4/BCL2/IKBKG/HRAS/MEF2C/MAPK1/CTLA4/HLA-DQA1/BAX/HLA-DRB1/HLA-DQB1	13
BP	GO:0006929	substrate-dependent cell migration	3/365	24/18862	0.0107605642014828	0.0214800888751185	0.00825542502269603	PTPRC/FN1/P2RY12	3
BP	GO:0014829	vascular associated smooth muscle contraction	3/365	24/18862	0.0107605642014828	0.0214800888751185	0.00825542502269603	EDNRB/EDN1/CHRM3	3
BP	GO:0016540	protein autoprocessing	3/365	24/18862	0.0107605642014828	0.0214800888751185	0.00825542502269603	PARP1/CASP4/SHH	3
BP	GO:0032753	positive regulation of interleukin-4 production	3/365	24/18862	0.0107605642014828	0.0214800888751185	0.00825542502269603	CEBPB/NLRP3/CD40LG	3
BP	GO:0036315	cellular response to sterol	3/365	24/18862	0.0107605642014828	0.0214800888751185	0.00825542502269603	DAG1/RORA/GRAMD1B	3
BP	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway	3/365	24/18862	0.0107605642014828	0.0214800888751185	0.00825542502269603	AR/IGF1/BMP2	3
BP	GO:0048710	regulation of astrocyte differentiation	3/365	24/18862	0.0107605642014828	0.0214800888751185	0.00825542502269603	IL6/NOTCH1/BMP2	3
BP	GO:0051004	regulation of lipoprotein lipase activity	3/365	24/18862	0.0107605642014828	0.0214800888751185	0.00825542502269603	SORT1/FURIN/LPL	3
BP	GO:0051788	response to misfolded protein	3/365	24/18862	0.0107605642014828	0.0214800888751185	0.00825542502269603	UGGT1/STUB1/CLU	3
BP	GO:0062149	detection of stimulus involved in sensory perception of pain	3/365	24/18862	0.0107605642014828	0.0214800888751185	0.00825542502269603	CXCR4/CXCL12/NTRK1	3
BP	GO:0002534	cytokine production involved in inflammatory response	5/365	69/18862	0.0107931911942184	0.0215124001182556	0.00826784317639452	ABCD1/PPARA/LEP/IL6/NOS2	5
BP	GO:0003143	embryonic heart tube morphogenesis	5/365	69/18862	0.0107931911942184	0.0215124001182556	0.00826784317639452	MEF2C/GATA4/NOTCH1/RYR2/SHH	5
BP	GO:0008088	axo-dendritic transport	5/365	69/18862	0.0107931911942184	0.0215124001182556	0.00826784317639452	PURA/DYNC1H1/HSPB1/SPAST/APP	5
BP	GO:0042446	hormone biosynthetic process	5/365	69/18862	0.0107931911942184	0.0215124001182556	0.00826784317639452	ATP1A1/CYP19A1/CYP17A1/EGR1/BMP2	5
BP	GO:0060966	regulation of gene silencing by RNA	7/365	125/18862	0.0109249039325426	0.0217666338724507	0.0083655526276076	AGO1/AGO2/PPARG/EGFR/IL6/BMP4/TERT	7
BP	GO:0018023	peptidyl-lysine trimethylation	4/365	45/18862	0.011007320358641	0.02188086394118	0.00840945457667377	MECP2/KMT2A/BRD4/KMT2D	4
BP	GO:0048701	embryonic cranial skeleton morphogenesis	4/365	45/18862	0.011007320358641	0.02188086394118	0.00840945457667377	GLI3/MED12/FGFR2/BMP4	4
BP	GO:0061647	histone H3-K9 modification	4/365	45/18862	0.011007320358641	0.02188086394118	0.00840945457667377	MECP2/KMT2A/DNMT1/BRCA1	4
BP	GO:0085029	extracellular matrix assembly	4/365	45/18862	0.011007320358641	0.02188086394118	0.00840945457667377	DAG1/ATP7A/NOTCH1/AGT	4
BP	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	4/365	45/18862	0.011007320358641	0.02188086394118	0.00840945457667377	EGFR/CCND1/TERT/CYP1A1	4
BP	GO:1901985	positive regulation of protein acetylation	4/365	45/18862	0.011007320358641	0.02188086394118	0.00840945457667377	ARNTL/MAPK3/BRCA1/NOS1	4
BP	GO:0019693	ribose phosphate metabolic process	16/365	435/18862	0.011030192055367	0.0219180050181438	0.00842372897646419	NPPA/ABCD1/NUPR1/PARP1/PINK1/EP300/RORA/P2RX7/HDAC4/PPARA/LRRK2/APP/ACSL4/IFNG/IGF1/XDH	16
BP	GO:0009132	nucleoside diphosphate metabolic process	8/365	156/18862	0.0111226319791495	0.0220933039008989	0.00849110145297302	NUPR1/EP300/P2RX7/HDAC4/PPARA/APP/IFNG/IGF1	8
BP	GO:1990868	response to chemokine	6/365	97/18862	0.0114051940171798	0.0226373854705798	0.00870020787850252	CCR5/CCL5/EDN1/CXCR4/CXCL12/CCL2	6
BP	GO:1990869	cellular response to chemokine	6/365	97/18862	0.0114051940171798	0.0226373854705798	0.00870020787850252	CCR5/CCL5/EDN1/CXCR4/CXCL12/CCL2	6
BP	GO:0006879	cellular iron ion homeostasis	5/365	70/18862	0.0114440764294848	0.0227059499741939	0.00872655921820577	ATP13A2/TF/CP/IFNG/MYC	5
BP	GO:0045089	positive regulation of innate immune response	10/365	223/18862	0.0118334223045629	0.0234695461697925	0.00902003152071947	MATR3/CCL5/IKBKG/HRAS/EP300/PRKDC/HSP90AA1/CREBBP/SRC/HMGB1	10
BP	GO:0010171	body morphogenesis	4/365	46/18862	0.0118759395267174	0.0234915598952528	0.00902849203785536	DAG1/EP300/DLX5/MMP2	4
BP	GO:0043268	positive regulation of potassium ion transport	4/365	46/18862	0.0118759395267174	0.0234915598952528	0.00902849203785536	NPPA/ANK2/KCNQ1/KCNH2	4
BP	GO:0050798	activated T cell proliferation	4/365	46/18862	0.0118759395267174	0.0234915598952528	0.00902849203785536	IL18/HMGB1/AGER/IGF1	4
BP	GO:0051932	synaptic transmission, GABAergic	4/365	46/18862	0.0118759395267174	0.0234915598952528	0.00902849203785536	STXBP1/CLN3/CNR1/GABRG2	4
BP	GO:0071354	cellular response to interleukin-6	4/365	46/18862	0.0118759395267174	0.0234915598952528	0.00902849203785536	ICAM1/SRC/IL6/STAT1	4
BP	GO:0120009	intermembrane lipid transfer	4/365	46/18862	0.0118759395267174	0.0234915598952528	0.00902849203785536	CETP/GRAMD1B/APOE/ABCA1	4
BP	GO:2000107	negative regulation of leukocyte apoptotic process	4/365	46/18862	0.0118759395267174	0.0234915598952528	0.00902849203785536	CCL5/KITLG/CXCL12/BMP4	4
BP	GO:0032984	protein-containing complex disassembly	13/365	328/18862	0.0118924605808675	0.0235153527314924	0.00903763631918468	GABARAP/IGF1R/MAP1LC3A/CTNNB1/CLN3/GSK3B/SETX/LAMP2/SPAST/ADRB2/MYC/CAV1/TRPV4	13
BP	GO:0001672	regulation of chromatin assembly or disassembly	3/365	25/18862	0.0120554444789742	0.0236855091602669	0.00910303240055306	PHF8/DNMT1/TET1	3
BP	GO:0001783	B cell apoptotic process	3/365	25/18862	0.0120554444789742	0.0236855091602669	0.00910303240055306	BCL2L11/BAX/IL10	3
BP	GO:0003148	outflow tract septum morphogenesis	3/365	25/18862	0.0120554444789742	0.0236855091602669	0.00910303240055306	LRP2/FGFR2/BMP4	3
BP	GO:0003171	atrioventricular valve development	3/365	25/18862	0.0120554444789742	0.0236855091602669	0.00910303240055306	GATA4/NOTCH1/BMP2	3
BP	GO:0021884	forebrain neuron development	3/365	25/18862	0.0120554444789742	0.0236855091602669	0.00910303240055306	ATP7A/FGFR2/FOXG1	3
BP	GO:0022011	myelination in peripheral nervous system	3/365	25/18862	0.0120554444789742	0.0236855091602669	0.00910303240055306	DAG1/NF1/DICER1	3
BP	GO:0031579	membrane raft organization	3/365	25/18862	0.0120554444789742	0.0236855091602669	0.00910303240055306	PTPRC/CLN3/CAV1	3
BP	GO:0032292	peripheral nervous system axon ensheathment	3/365	25/18862	0.0120554444789742	0.0236855091602669	0.00910303240055306	DAG1/NF1/DICER1	3
BP	GO:0032682	negative regulation of chemokine production	3/365	25/18862	0.0120554444789742	0.0236855091602669	0.00910303240055306	KLF4/IL6/IL10	3
BP	GO:0033233	regulation of protein sumoylation	3/365	25/18862	0.0120554444789742	0.0236855091602669	0.00910303240055306	CTNNB1/HDAC4/EGR1	3
BP	GO:0048641	regulation of skeletal muscle tissue development	3/365	25/18862	0.0120554444789742	0.0236855091602669	0.00910303240055306	BCL2/MEF2C/SHH	3
BP	GO:0086013	membrane repolarization during cardiac muscle cell action potential	3/365	25/18862	0.0120554444789742	0.0236855091602669	0.00910303240055306	ATP1A1/KCNQ1/KCNH2	3
BP	GO:0090169	regulation of spindle assembly	3/365	25/18862	0.0120554444789742	0.0236855091602669	0.00910303240055306	DYNC1H1/HSPA1B/HSPA1A	3
BP	GO:0097164	ammonium ion metabolic process	3/365	25/18862	0.0120554444789742	0.0236855091602669	0.00910303240055306	ATP7A/BCHE/GRIN2A	3
BP	GO:1900078	positive regulation of cellular response to insulin stimulus	3/365	25/18862	0.0120554444789742	0.0236855091602669	0.00910303240055306	SORL1/SRC/LEP	3
BP	GO:1903523	negative regulation of blood circulation	3/365	25/18862	0.0120554444789742	0.0236855091602669	0.00910303240055306	ATP1A1/PIK3CG/AGER	3
BP	GO:1905563	negative regulation of vascular endothelial cell proliferation	3/365	25/18862	0.0120554444789742	0.0236855091602669	0.00910303240055306	MEF2C/PPARG/CCL2	3
BP	GO:0007040	lysosome organization	5/365	71/18862	0.0121211844879995	0.0237878813686499	0.00914237702783217	CLN3/SCARB2/MTOR/LRRK2/ABCA1	5
BP	GO:0031507	heterochromatin assembly	5/365	71/18862	0.0121211844879995	0.0237878813686499	0.00914237702783217	DNMT3A/PHF8/DNMT1/TET1/CDKN2A	5
BP	GO:0080171	lytic vacuole organization	5/365	71/18862	0.0121211844879995	0.0237878813686499	0.00914237702783217	CLN3/SCARB2/MTOR/LRRK2/ABCA1	5
BP	GO:0022618	ribonucleoprotein complex assembly	10/365	224/18862	0.0121810137624557	0.023896336593963	0.00918405953604232	SMN1/AGO1/AGO2/PRKDC/RPL5/HSP90AA1/HSP90AB1/SETX/ATM/DICER1	10
BP	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	6/365	99/18862	0.0125276822971771	0.0245580109151405	0.00943836028776088	DYNC1H1/HLA-DQA1/CANX/CTSD/HLA-DRB1/HLA-DQB1	6
BP	GO:0022600	digestive system process	6/365	99/18862	0.0125276822971771	0.0245580109151405	0.00943836028776088	CEL/LEP/SERPINA3/KCNQ1/GHRL/CHRM3	6
BP	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	4/365	47/18862	0.0127873321939615	0.0250295051246052	0.00961956927239318	ICAM1/VCAM1/IL1RAPL1/CDH2	4
BP	GO:0035722	interleukin-12-mediated signaling pathway	4/365	47/18862	0.0127873321939615	0.0250295051246052	0.00961956927239318	MIF/IFNG/SOD2/IL10	4
BP	GO:0042572	retinol metabolic process	4/365	47/18862	0.0127873321939615	0.0250295051246052	0.00961956927239318	CYP3A5/CYP2D6/TTR/CYP1A1	4
BP	GO:0045332	phospholipid translocation	4/365	47/18862	0.0127873321939615	0.0250295051246052	0.00961956927239318	MFSD2A/P2RX7/ABCA1/FASLG	4
BP	GO:0007098	centrosome cycle	7/365	129/18862	0.0128347662420635	0.0251129594433498	0.00965164320259063	CTNNB1/GADD45A/WDR62/BRCA1/ALMS1/BRCA2/AURKA	7
BP	GO:0140014	mitotic nuclear division	12/365	296/18862	0.0130292636524436	0.0254839932574326	0.00979424232547385	EDN1/SMC1A/RAD21/ATM/SPAST/PRKCA/HSPA1B/BMP4/HSPA1A/IGF1/PDGFRB/AURKA	12
BP	GO:0010927	cellular component assembly involved in morphogenesis	6/365	100/18862	0.0131170503260179	0.0256461118439961	0.00985654922950678	EDN1/DAG1/DICER1/TLR2/KRT8/PDGFRB	6
BP	GO:0002313	mature B cell differentiation involved in immune response	3/365	26/18862	0.0134358748257393	0.0262009570931147	0.0100697924511679	XBP1/IL6/IL10	3
BP	GO:0010894	negative regulation of steroid biosynthetic process	3/365	26/18862	0.0134358748257393	0.0262009570931147	0.0100697924511679	ATP1A1/APOE/BMP2	3
BP	GO:0018904	ether metabolic process	3/365	26/18862	0.0134358748257393	0.0262009570931147	0.0100697924511679	TXN/PLA2G6/PLA2G4A	3
BP	GO:0098868	bone growth	3/365	26/18862	0.0134358748257393	0.0262009570931147	0.0100697924511679	LEP/FGFR2/LEPR	3
BP	GO:1901623	regulation of lymphocyte chemotaxis	3/365	26/18862	0.0134358748257393	0.0262009570931147	0.0100697924511679	CCL5/CCL2/ADAM10	3
BP	GO:1904353	regulation of telomere capping	3/365	26/18862	0.0134358748257393	0.0262009570931147	0.0100697924511679	MAPK1/ATM/MAPK3	3
BP	GO:1905063	regulation of vascular associated smooth muscle cell differentiation	3/365	26/18862	0.0134358748257393	0.0262009570931147	0.0100697924511679	DNMT1/KIT/SOD2	3
BP	GO:0048002	antigen processing and presentation of peptide antigen	9/365	194/18862	0.0134921554052963	0.0263009092705106	0.0101082069899133	CYBB/IKBKG/DYNC1H1/HLA-DQA1/B2M/CANX/CTSD/HLA-DRB1/HLA-DQB1	9
BP	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	6/365	101/18862	0.0137255669713512	0.0267087274131001	0.0102649434037436	GADD45A/SRC/EGFR/CCND1/CDKN1A/CDKN2A	6
BP	GO:0001913	T cell mediated cytotoxicity	4/365	48/18862	0.0137421862673822	0.0267087274131001	0.0102649434037436	PTPRC/AGER/B2M/HLA-DRB1	4
BP	GO:0033628	regulation of cell adhesion mediated by integrin	4/365	48/18862	0.0137421862673822	0.0267087274131001	0.0102649434037436	CCL5/PIK3CG/SERPINE1/P2RY12	4
BP	GO:0043330	response to exogenous dsRNA	4/365	48/18862	0.0137421862673822	0.0267087274131001	0.0102649434037436	NFKBIA/MAPK1/MAPK3/CAV1	4
BP	GO:0051204	protein insertion into mitochondrial membrane	4/365	48/18862	0.0137421862673822	0.0267087274131001	0.0102649434037436	BCL2/HSP90AA1/BCL2L11/BAX	4
BP	GO:0061028	establishment of endothelial barrier	4/365	48/18862	0.0137421862673822	0.0267087274131001	0.0102649434037436	TNFRSF1A/ICAM1/VEGFA/PROC	4
BP	GO:1990090	cellular response to nerve growth factor stimulus	4/365	48/18862	0.0137421862673822	0.0267087274131001	0.0102649434037436	SORT1/NGF/APP/NTRK1	4
BP	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	4/365	48/18862	0.0137421862673822	0.0267087274131001	0.0102649434037436	PTPRC/ATF3/AGT/CAV1	4
BP	GO:0006310	DNA recombination	12/365	299/18862	0.0140095656959494	0.0272182876216032	0.0104607822627122	PTPRC/PARP1/ZFYVE26/PRKDC/SETX/RAD21/ATM/BRCA1/HMGB1/BRCA2/CD40LG/IL10	12
BP	GO:0051259	protein complex oligomerization	10/365	229/18862	0.014035769304751	0.0272590784939022	0.0104764593853644	TRPM1/MIF/SNCA/SPAST/B2M/GRIN1/HLA-DRB1/SOD2/KCNA2/GRIN2B	10
BP	GO:0048285	organelle fission	17/365	486/18862	0.0141470021015741	0.0274649143173735	0.0105555680993707	EDN1/PINK1/SMC1A/RAD21/ATM/BCL2L11/SPAST/LRRK2/PRKCA/KDR/BRCA2/HSPA1B/BMP4/HSPA1A/IGF1/PDGFRB/AURKA	17
BP	GO:0045739	positive regulation of DNA repair	5/365	74/18862	0.0143143415326914	0.0277691859088609	0.0106725085517433	PARP1/PRKDC/BRCA1/EGFR/HMGB1	5
BP	GO:0046503	glycerolipid catabolic process	5/365	74/18862	0.0143143415326914	0.0277691859088609	0.0106725085517433	SORL1/PIK3CG/PLA2G6/LPL/PLA2G4A	5
BP	GO:0036503	ERAD pathway	6/365	102/18862	0.0143535264873517	0.0278245769017773	0.010693796926834	UGGT1/STUB1/UBE2J1/UBQLN2/DNAJC10/CAV1	6
BP	GO:0044264	cellular polysaccharide metabolic process	6/365	102/18862	0.0143535264873517	0.0278245769017773	0.010693796926834	MTOR/GSK3B/HMGB1/LEPR/IGF1/POMC	6
BP	GO:0010977	negative regulation of neuron projection development	7/365	132/18862	0.0144167884225477	0.0279368643478767	0.0107369522693306	SPP1/RTN4/LRRK2/APOE/B2M/NGFR/TRPV4	7
BP	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	10/365	230/18862	0.014430782084219	0.0279536319129542	0.010743396533929	EDN1/ADRB2/PRKCA/ABCA1/DRD4/CNR1/CHRM3/CRHR1/CALCR/P2RY12	10
BP	GO:0009948	anterior/posterior axis specification	4/365	49/18862	0.0147411542538793	0.0285126390852935	0.0109582393041441	DDIT3/BMP4/AURKA/SHH	4
BP	GO:0032692	negative regulation of interleukin-1 production	4/365	49/18862	0.0147411542538793	0.0285126390852935	0.0109582393041441	GHRL/NLRP3/IGF1/IL10	4
BP	GO:0071349	cellular response to interleukin-12	4/365	49/18862	0.0147411542538793	0.0285126390852935	0.0109582393041441	MIF/IFNG/SOD2/IL10	4
BP	GO:0120178	steroid hormone biosynthetic process	4/365	49/18862	0.0147411542538793	0.0285126390852935	0.0109582393041441	CYP19A1/CYP17A1/EGR1/BMP2	4
BP	GO:0071826	ribonucleoprotein complex subunit organization	10/365	231/18862	0.0148340485831479	0.0285821440084786	0.0109849520745334	SMN1/AGO1/AGO2/PRKDC/RPL5/HSP90AA1/HSP90AB1/SETX/ATM/DICER1	10
BP	GO:0002825	regulation of T-helper 1 type immune response	3/365	27/18862	0.0149026003908798	0.0285821440084786	0.0109849520745334	IL18/IL1R1/PLA2G4A	3
BP	GO:0010818	T cell chemotaxis	3/365	27/18862	0.0149026003908798	0.0285821440084786	0.0109849520745334	CCL5/PIK3CG/ADAM10	3
BP	GO:0042501	serine phosphorylation of STAT protein	3/365	27/18862	0.0149026003908798	0.0285821440084786	0.0109849520745334	GADD45A/IFNG/IL24	3
BP	GO:0045672	positive regulation of osteoclast differentiation	3/365	27/18862	0.0149026003908798	0.0285821440084786	0.0109849520745334	FOS/IFNG/TNFSF11	3
BP	GO:0048799	animal organ maturation	3/365	27/18862	0.0149026003908798	0.0285821440084786	0.0109849520745334	LEP/IGF1/BMP2	3
BP	GO:0070199	establishment of protein localization to chromosome	3/365	27/18862	0.0149026003908798	0.0285821440084786	0.0109849520745334	ATM/BRCA2/TERT	3
BP	GO:0090140	regulation of mitochondrial fission	3/365	27/18862	0.0149026003908798	0.0285821440084786	0.0109849520745334	PINK1/LRRK2/KDR	3
BP	GO:0098901	regulation of cardiac muscle cell action potential	3/365	27/18862	0.0149026003908798	0.0285821440084786	0.0109849520745334	ANK2/RYR2/CAV1	3
BP	GO:1902473	regulation of protein localization to synapse	3/365	27/18862	0.0149026003908798	0.0285821440084786	0.0109849520745334	HRAS/DAG1/ADAM10	3
BP	GO:1904357	negative regulation of telomere maintenance via telomere lengthening	3/365	27/18862	0.0149026003908798	0.0285821440084786	0.0109849520745334	PARP1/HNRNPA1/SRC	3
BP	GO:0045017	glycerolipid biosynthetic process	11/365	266/18862	0.0149088654481301	0.0285821440084786	0.0109849520745334	PIK3R2/CLN3/MFSD2A/ATM/PIK3CG/PLA2G6/ACSL4/LPL/PLA2G4A/HTR2C/C3	11
BP	GO:0002495	antigen processing and presentation of peptide antigen via MHC class II	6/365	103/18862	0.0150012186990658	0.0285821440084786	0.0109849520745334	DYNC1H1/HLA-DQA1/CANX/CTSD/HLA-DRB1/HLA-DQB1	6
BP	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	6/365	103/18862	0.0150012186990658	0.0285821440084786	0.0109849520745334	EDNRB/EDN1/AGTR1/AGT/HTR2C/P2RY12	6
BP	GO:0030593	neutrophil chemotaxis	6/365	103/18862	0.0150012186990658	0.0285821440084786	0.0109849520745334	CCL5/EDN1/PIK3CG/PPIB/CCL2/THBS4	6
BP	GO:0001820	serotonin secretion	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	CNR1/SLC6A4	2
BP	GO:0002024	diet induced thermogenesis	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	SORL1/ADRB2	2
BP	GO:0002327	immature B cell differentiation	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	ATM/KIT	2
BP	GO:0002424	T cell mediated immune response to tumor cell	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	HMGB1/HLA-DRB1	2
BP	GO:0003129	heart induction	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	BMP4/BMP2	2
BP	GO:0007220	Notch receptor processing	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	PSEN2/ADAM10	2
BP	GO:0009629	response to gravity	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	FOS/BGLAP	2
BP	GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	EIF2AK2/DNAJC3	2
BP	GO:0019062	virion attachment to host cell	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	HSP90AB1/ICAM1	2
BP	GO:0019614	catechol-containing compound catabolic process	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	MAOA/DBH	2
BP	GO:0021702	cerebellar Purkinje cell differentiation	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	ATP7A/RORA	2
BP	GO:0030238	male sex determination	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	GNRH1/AR	2
BP	GO:0031284	positive regulation of guanylate cyclase activity	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	NOS2/NOS1	2
BP	GO:0031652	positive regulation of heat generation	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	TNFSF11/CNR1	2
BP	GO:0032000	positive regulation of fatty acid beta-oxidation	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	ABCD1/PPARA	2
BP	GO:0032351	negative regulation of hormone metabolic process	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	ATP1A1/BMP2	2
BP	GO:0032661	regulation of interleukin-18 production	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	TLR2/IL10	2
BP	GO:0032817	regulation of natural killer cell proliferation	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	IL18/LEP	2
BP	GO:0033033	negative regulation of myeloid cell apoptotic process	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	BCL2/KITLG	2
BP	GO:0033327	Leydig cell differentiation	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	CCND1/AR	2
BP	GO:0033483	gas homeostasis	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	SOD2/CAV1	2
BP	GO:0033860	regulation of NAD(P)H oxidase activity	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	AGTR1/AGT	2
BP	GO:0034350	regulation of glial cell apoptotic process	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	PRKCA/CCL2	2
BP	GO:0034776	response to histamine	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	DRD4/GABRG2	2
BP	GO:0035542	regulation of SNARE complex assembly	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	STXBP1/SNCA	2
BP	GO:0042424	catecholamine catabolic process	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	MAOA/DBH	2
BP	GO:0042428	serotonin metabolic process	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	ATP7A/GRIN2A	2
BP	GO:0043084	penile erection	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	EDNRB/CNR1	2
BP	GO:0048715	negative regulation of oligodendrocyte differentiation	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	NF1/NOTCH1	2
BP	GO:0051573	negative regulation of histone H3-K9 methylation	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	DNMT1/BRCA1	2
BP	GO:0051593	response to folic acid	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	BCHE/MTHFR	2
BP	GO:0060068	vagina development	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	LRP2/BAX	2
BP	GO:0060525	prostate glandular acinus development	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	NOTCH1/FGFR2	2
BP	GO:0060947	cardiac vascular smooth muscle cell differentiation	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	NOTCH1/VEGFA	2
BP	GO:0070091	glucagon secretion	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	LEP/IL6	2
BP	GO:0070092	regulation of glucagon secretion	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	LEP/IL6	2
BP	GO:0070099	regulation of chemokine-mediated signaling pathway	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	CCL5/EDN1	2
BP	GO:0070391	response to lipoteichoic acid	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	CD14/TLR2	2
BP	GO:0071223	cellular response to lipoteichoic acid	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	CD14/TLR2	2
BP	GO:0071313	cellular response to caffeine	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	RYR2/CASQ2	2
BP	GO:0072124	regulation of glomerular mesangial cell proliferation	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	BMP4/EGR1	2
BP	GO:0072537	fibroblast activation	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	LEP/PDGFRB	2
BP	GO:0090030	regulation of steroid hormone biosynthetic process	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	ATP1A1/BMP2	2
BP	GO:0097050	type B pancreatic cell apoptotic process	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	IL6/RYR2	2
BP	GO:0097084	vascular associated smooth muscle cell development	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	NOTCH1/VEGFA	2
BP	GO:0097278	complement-dependent cytotoxicity	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	HSP90AB1/C3	2
BP	GO:1902237	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	BCL2L11/DDIT3	2
BP	GO:1902510	regulation of apoptotic DNA fragmentation	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	IL6/BAX	2
BP	GO:1902959	regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	SORL1/AGER	2
BP	GO:1904321	response to forskolin	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	CFTR/AHR	2
BP	GO:1904322	cellular response to forskolin	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	CFTR/AHR	2
BP	GO:1904338	regulation of dopaminergic neuron differentiation	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	GSK3B/SHH	2
BP	GO:1904350	regulation of protein catabolic process in the vacuole	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	LRP2/ATP13A2	2
BP	GO:1905651	regulation of artery morphogenesis	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	AKT3/NOTCH1	2
BP	GO:1990535	neuron projection maintenance	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	ABCD1/APP	2
BP	GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	2/365	10/18862	0.0151648096888699	0.0285821440084786	0.0109849520745334	HMGB1/LPL	2
BP	GO:0019080	viral gene expression	9/365	198/18862	0.0152324978947715	0.0286993858823737	0.0110300115482204	CCL5/RPS27A/RPS6/EP300/RPL5/TARDBP/SP1/FURIN/JUN	9
BP	GO:0016311	dephosphorylation	17/365	491/18862	0.0154903793610183	0.0291747555147786	0.0112127099709877	PTPRC/BCL2/EIF2AK2/MEF2C/ATP1A1/PINK1/HTT/MTOR/HSP90AB1/GSK3B/SRC/DMPK/LRRK2/PPP1R15A/IFNG/PDGFRB/BMP2	17
BP	GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	6/365	104/18862	0.0156689288265805	0.0294898142676455	0.0113337962442875	DYNC1H1/HLA-DQA1/CANX/CTSD/HLA-DRB1/HLA-DQB1	6
BP	GO:0016079	synaptic vesicle exocytosis	6/365	104/18862	0.0156689288265805	0.0294898142676455	0.0113337962442875	STXBP1/DNAJC5/GSK3B/SNCA/LRRK2/CNR1	6
BP	GO:0034204	lipid translocation	4/365	50/18862	0.0157848531150453	0.0296546737990478	0.0113971565734128	MFSD2A/P2RX7/ABCA1/FASLG	4
BP	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	4/365	50/18862	0.0157848531150453	0.0296546737990478	0.0113971565734128	CCL5/SNCA/UBQLN2/ADRB2	4
BP	GO:0070671	response to interleukin-12	4/365	50/18862	0.0157848531150453	0.0296546737990478	0.0113971565734128	MIF/IFNG/SOD2/IL10	4
BP	GO:0070741	response to interleukin-6	4/365	50/18862	0.0157848531150453	0.0296546737990478	0.0113971565734128	ICAM1/SRC/IL6/STAT1	4
BP	GO:1990089	response to nerve growth factor	4/365	50/18862	0.0157848531150453	0.0296546737990478	0.0113971565734128	SORT1/NGF/APP/NTRK1	4
BP	GO:0002792	negative regulation of peptide secretion	5/365	76/18862	0.0159156101404655	0.0298895957930378	0.0114874439515909	UCP2/LEP/APOE/GHRL/DRD4	5
BP	GO:0019882	antigen processing and presentation	10/365	234/18862	0.0160943636076773	0.0302144544916008	0.0116122966300201	CYBB/IKBKG/DYNC1H1/ICAM1/HLA-DQA1/B2M/CANX/CTSD/HLA-DRB1/HLA-DQB1	10
BP	GO:0051783	regulation of nuclear division	7/365	135/18862	0.0161334117493764	0.0302769010743047	0.0116362966741742	EDN1/RAD21/ATM/BMP4/IGF1/PDGFRB/AURKA	7
BP	GO:0035601	protein deacylation	6/365	105/18862	0.0163569373143576	0.030685379893673	0.0117932870053716	PINK1/EP300/HDAC4/LRRK2/IFNG/VEGFA	6
BP	GO:0008053	mitochondrial fusion	3/365	28/18862	0.0164562190303289	0.0307833632611657	0.011830944873014	HUWE1/SPG7/BAX	3
BP	GO:0019098	reproductive behavior	3/365	28/18862	0.0164562190303289	0.0307833632611657	0.011830944873014	HDAC4/APP/DBH	3
BP	GO:0031063	regulation of histone deacetylation	3/365	28/18862	0.0164562190303289	0.0307833632611657	0.011830944873014	PINK1/LRRK2/VEGFA	3
BP	GO:0032607	interferon-alpha production	3/365	28/18862	0.0164562190303289	0.0307833632611657	0.011830944873014	HMGB1/STAT1/IL10	3
BP	GO:0032647	regulation of interferon-alpha production	3/365	28/18862	0.0164562190303289	0.0307833632611657	0.011830944873014	HMGB1/STAT1/IL10	3
BP	GO:0060603	mammary gland duct morphogenesis	3/365	28/18862	0.0164562190303289	0.0307833632611657	0.011830944873014	SRC/AR/FGFR2	3
BP	GO:0060795	cell fate commitment involved in formation of primary germ layer	3/365	28/18862	0.0164562190303289	0.0307833632611657	0.011830944873014	KLF4/SOX2/BMP4	3
BP	GO:0140058	neuron projection arborization	3/365	28/18862	0.0164562190303289	0.0307833632611657	0.011830944873014	LRP2/MFSD2A/LRRK2	3
BP	GO:0008589	regulation of smoothened signaling pathway	5/365	77/18862	0.016759224257419	0.0312942489344742	0.0120272931467892	GLI3/CREBBP/RORA/FGFR2/SHH	5
BP	GO:0034121	regulation of toll-like receptor signaling pathway	5/365	77/18862	0.016759224257419	0.0312942489344742	0.0120272931467892	RTN4/CD14/HMGB1/TLR2/CAV1	5
BP	GO:0090049	regulation of cell migration involved in sprouting angiogenesis	5/365	77/18862	0.016759224257419	0.0312942489344742	0.0120272931467892	KLF4/AKT3/KDR/NOTCH1/VEGFA	5
BP	GO:1901616	organic hydroxy compound catabolic process	5/365	77/18862	0.016759224257419	0.0312942489344742	0.0120272931467892	CEL/MAOA/ALDH2/APOE/DBH	5
BP	GO:1903363	negative regulation of cellular protein catabolic process	5/365	77/18862	0.016759224257419	0.0312942489344742	0.0120272931467892	RPL5/ATP13A2/HSP90AB1/FURIN/SHH	5
BP	GO:0032206	positive regulation of telomere maintenance	4/365	51/18862	0.0168738641858067	0.0314746276366759	0.0120966179461592	HNRNPA1/MAPK1/ATM/MAPK3	4
BP	GO:0032964	collagen biosynthetic process	4/365	51/18862	0.0168738641858067	0.0314746276366759	0.0120966179461592	PPARG/IL6/BMP4/PDGFRB	4
BP	GO:0043277	apoptotic cell clearance	4/365	51/18862	0.0168738641858067	0.0314746276366759	0.0120966179461592	HMGB1/C4A/CCL2/C3	4
BP	GO:0042742	defense response to bacterium	13/365	344/18862	0.0170204834476196	0.0317368045475031	0.0121973801842766	CD4/CEBPB/TNFRSF1A/PLA2G6/TF/IL6/TLR2/SERPINE1/NOS2/HP/IL10/MBL2/MPO	13
BP	GO:0010770	positive regulation of cell morphogenesis involved in differentiation	5/365	78/18862	0.0176320107185455	0.03285366468525	0.0126266221292989	PRKDC/CUX1/CDKL5/IL1RAPL1/RELN	5
BP	GO:0035050	embryonic heart tube development	5/365	78/18862	0.0176320107185455	0.03285366468525	0.0126266221292989	MEF2C/GATA4/NOTCH1/RYR2/SHH	5
BP	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	11/365	273/18862	0.0177351408663596	0.0330340666528563	0.0126959558702428	L1CAM/KLF4/ICAM1/MPZ/VCAM1/IL1RN/IL1RAPL1/CDH2/ADIPOQ/BMP2/IL10	11
BP	GO:0006998	nuclear envelope organization	4/365	52/18862	0.0180087331532471	0.0333503229829784	0.0128175024074315	TARDBP/SPAST/DMPK/PRKCA	4
BP	GO:0001916	positive regulation of T cell mediated cytotoxicity	3/365	29/18862	0.0180971883456861	0.0333503229829784	0.0128175024074315	PTPRC/B2M/HLA-DRB1	3
BP	GO:0003209	cardiac atrium morphogenesis	3/365	29/18862	0.0180971883456861	0.0333503229829784	0.0128175024074315	GATA4/NOTCH1/BMP2	3
BP	GO:0006884	cell volume homeostasis	3/365	29/18862	0.0180971883456861	0.0333503229829784	0.0128175024074315	CLN3/P2RX7/TRPV4	3
BP	GO:0007435	salivary gland morphogenesis	3/365	29/18862	0.0180971883456861	0.0333503229829784	0.0128175024074315	DAG1/FGFR2/SHH	3
BP	GO:0010586	miRNA metabolic process	3/365	29/18862	0.0180971883456861	0.0333503229829784	0.0128175024074315	HRAS/AGO2/DICER1	3
BP	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	3/365	29/18862	0.0180971883456861	0.0333503229829784	0.0128175024074315	EP300/HSP90AB1/CREBBP	3
BP	GO:0035066	positive regulation of histone acetylation	3/365	29/18862	0.0180971883456861	0.0333503229829784	0.0128175024074315	MAPK3/BRCA1/NOS1	3
BP	GO:0043032	positive regulation of macrophage activation	3/365	29/18862	0.0180971883456861	0.0333503229829784	0.0128175024074315	LRRK2/PLA2G4A/IL10	3
BP	GO:0045939	negative regulation of steroid metabolic process	3/365	29/18862	0.0180971883456861	0.0333503229829784	0.0128175024074315	ATP1A1/APOE/BMP2	3
BP	GO:0050690	regulation of defense response to virus by virus	3/365	29/18862	0.0180971883456861	0.0333503229829784	0.0128175024074315	CD4/EIF2AK2/B2M	3
BP	GO:0060325	face morphogenesis	3/365	29/18862	0.0180971883456861	0.0333503229829784	0.0128175024074315	EP300/DLX5/MMP2	3
BP	GO:0061036	positive regulation of cartilage development	3/365	29/18862	0.0180971883456861	0.0333503229829784	0.0128175024074315	GLI3/BMP4/BMP2	3
BP	GO:0070723	response to cholesterol	3/365	29/18862	0.0180971883456861	0.0333503229829784	0.0128175024074315	CCR5/DAG1/GRAMD1B	3
BP	GO:0071549	cellular response to dexamethasone stimulus	3/365	29/18862	0.0180971883456861	0.0333503229829784	0.0128175024074315	EIF4E/ICAM1/EGFR	3
BP	GO:0072337	modified amino acid transport	3/365	29/18862	0.0180971883456861	0.0333503229829784	0.0128175024074315	LRP2/GJA1/SLC6A8	3
BP	GO:1902624	positive regulation of neutrophil migration	3/365	29/18862	0.0180971883456861	0.0333503229829784	0.0128175024074315	EDN1/IL1R1/THBS4	3
BP	GO:1903019	negative regulation of glycoprotein metabolic process	3/365	29/18862	0.0180971883456861	0.0333503229829784	0.0128175024074315	AGO2/ITM2B/CST3	3
BP	GO:1903846	positive regulation of cellular response to transforming growth factor beta stimulus	3/365	29/18862	0.0180971883456861	0.0333503229829784	0.0128175024074315	EP300/HSP90AB1/CREBBP	3
BP	GO:0001787	natural killer cell proliferation	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	IL18/LEP	2
BP	GO:0003157	endocardium development	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	NRG1/NOTCH1	2
BP	GO:0006527	arginine catabolic process	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	NOS2/NOS1	2
BP	GO:0006707	cholesterol catabolic process	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	CEL/APOE	2
BP	GO:0010960	magnesium ion homeostasis	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	EGFR/ANK3	2
BP	GO:0016127	sterol catabolic process	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	CEL/APOE	2
BP	GO:0021889	olfactory bulb interneuron differentiation	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	DLX5/ERBB4	2
BP	GO:0021936	regulation of cerebellar granule cell precursor proliferation	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	SHH/SLC6A4	2
BP	GO:0031223	auditory behavior	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	HTT/NRXN1	2
BP	GO:0032493	response to bacterial lipoprotein	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	CD14/TLR2	2
BP	GO:0032621	interleukin-18 production	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	TLR2/IL10	2
BP	GO:0033210	leptin-mediated signaling pathway	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	LEP/LEPR	2
BP	GO:0033625	positive regulation of integrin activation	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	SRC/P2RY12	2
BP	GO:0034163	regulation of toll-like receptor 9 signaling pathway	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	RTN4/HMGB1	2
BP	GO:0036363	transforming growth factor beta activation	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	HSP90AB1/FURIN	2
BP	GO:0036490	regulation of translation in response to endoplasmic reticulum stress	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	DNAJC3/PPP1R15A	2
BP	GO:0042447	hormone catabolic process	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	SPP1/CYP19A1	2
BP	GO:0045602	negative regulation of endothelial cell differentiation	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	VEGFA/XDH	2
BP	GO:0045628	regulation of T-helper 2 cell differentiation	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	IL18/NLRP3	2
BP	GO:0045945	positive regulation of transcription by RNA polymerase III	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	MTOR/AR	2
BP	GO:0046598	positive regulation of viral entry into host cell	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	CD4/HLA-DRB1	2
BP	GO:0048742	regulation of skeletal muscle fiber development	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	BCL2/HDAC4	2
BP	GO:0051974	negative regulation of telomerase activity	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	PPARG/SRC	2
BP	GO:0060009	Sertoli cell development	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	ICAM1/NTRK1	2
BP	GO:0060019	radial glial cell differentiation	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	GLI3/CDH2	2
BP	GO:0060123	regulation of growth hormone secretion	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	CHD7/GHRL	2
BP	GO:0060379	cardiac muscle cell myoblast differentiation	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	NRG1/NOTCH1	2
BP	GO:0070106	interleukin-27-mediated signaling pathway	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	CANX/STAT1	2
BP	GO:0070673	response to interleukin-18	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	OCLN/IL18	2
BP	GO:0070757	interleukin-35-mediated signaling pathway	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	CANX/STAT1	2
BP	GO:0071888	macrophage apoptotic process	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	MEF2C/CDKN2A	2
BP	GO:0072205	metanephric collecting duct development	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	BMP4/SHH	2
BP	GO:0075294	positive regulation by symbiont of entry into host	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	CD4/HLA-DRB1	2
BP	GO:0086016	AV node cell action potential	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	RYR2/SCN5A	2
BP	GO:0086027	AV node cell to bundle of His cell signaling	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	RYR2/SCN5A	2
BP	GO:0090160	Golgi to lysosome transport	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	SORT1/CLN3	2
BP	GO:0099566	regulation of postsynaptic cytosolic calcium ion concentration	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	ITPR1/GRIA1	2
BP	GO:1902033	regulation of hematopoietic stem cell proliferation	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	EIF2AK2/KITLG	2
BP	GO:2000551	regulation of T-helper 2 cell cytokine production	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	IL6/NLRP3	2
BP	GO:2000615	regulation of histone H3-K9 acetylation	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	KMT2A/BRCA1	2
BP	GO:2000644	regulation of receptor catabolic process	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	FURIN/APOE	2
BP	GO:2000826	regulation of heart morphogenesis	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	BMP4/BMP2	2
BP	GO:2001269	positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	2/365	11/18862	0.0182999861687264	0.0333503229829784	0.0128175024074315	FAS/BAX	2
BP	GO:0001892	embryonic placenta development	5/365	79/18862	0.0185343434868474	0.0337304429103474	0.0129635935888168	CEBPB/MAPK1/FGFR2/KRT8/IL10	5
BP	GO:0002312	B cell activation involved in immune response	5/365	79/18862	0.0185343434868474	0.0337304429103474	0.0129635935888168	XBP1/PTPRC/IL6/CD40LG/IL10	5
BP	GO:0006826	iron ion transport	5/365	79/18862	0.0185343434868474	0.0337304429103474	0.0129635935888168	ATP7A/TF/B2M/CP/IFNG	5
BP	GO:0031397	negative regulation of protein ubiquitination	5/365	79/18862	0.0185343434868474	0.0337304429103474	0.0129635935888168	RPL5/MTOR/HSPA1B/HSPA1A/CAV1	5
BP	GO:0030902	hindbrain development	7/365	139/18862	0.0186411627799331	0.0339130503963051	0.0130337749748283	BCL2/ATP7A/MECP2/RORA/SCN5A/SHH/SLC6A4	7
BP	GO:0008544	epidermis development	16/365	463/18862	0.0188106976427441	0.0342095870264498	0.0131477426558224	KLF4/BCL2/CTNNB1/ATP7A/PPARA/EGFR/FURIN/ALDH3A2/NOTCH1/FGFR2/BMP4/NGFR/TXNIP/HLA-DRB1/KRT8/SHH	16
BP	GO:0061025	membrane fusion	8/365	172/18862	0.0190158424222721	0.0345586525132542	0.0132818987094159	CCR5/CD4/STXBP1/ATP13A2/CLN3/HUWE1/SNCA/CXCR4	8
BP	GO:0140056	organelle localization by membrane tethering	8/365	172/18862	0.0190158424222721	0.0345586525132542	0.0132818987094159	STXBP1/PSEN2/CLN3/HSP90AA1/VAPB/DYNC1H1/ALMS1/CFTR	8
BP	GO:0001706	endoderm formation	4/365	53/18862	0.0191899700921049	0.0348509033525598	0.0133942192359153	MMP9/SOX2/MMP2/FN1	4
BP	GO:0048747	muscle fiber development	4/365	53/18862	0.0191899700921049	0.0348509033525598	0.0133942192359153	BCL2/HDAC4/BMP4/VEGFA	4
BP	GO:0031023	microtubule organizing center organization	7/365	140/18862	0.019308512741918	0.0350458253544137	0.0134691334497687	CTNNB1/GADD45A/WDR62/BRCA1/ALMS1/BRCA2/AURKA	7
BP	GO:0098732	macromolecule deacylation	6/365	109/18862	0.0193173874947428	0.0350458253544137	0.0134691334497687	PINK1/EP300/HDAC4/LRRK2/IFNG/VEGFA	6
BP	GO:1902414	protein localization to cell junction	6/365	109/18862	0.0193173874947428	0.0350458253544137	0.0134691334497687	HRAS/DAG1/HSPB1/ADAM10/GRIN2A/NRXN1	6
BP	GO:0001895	retina homeostasis	5/365	80/18862	0.0194665839529735	0.0352920333944799	0.0135637583848221	HSPB1/SLC2A1/TF/B2M/PRDX1	5
BP	GO:0030433	ubiquitin-dependent ERAD pathway	5/365	80/18862	0.0194665839529735	0.0352920333944799	0.0135637583848221	STUB1/UBE2J1/UBQLN2/DNAJC10/CAV1	5
BP	GO:0001844	protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	3/365	30/18862	0.019825832476054	0.0357575489936826	0.0137426696150529	BCL2/BCL2L11/BAX	3
BP	GO:0002828	regulation of type 2 immune response	3/365	30/18862	0.019825832476054	0.0357575489936826	0.0137426696150529	IL18/IL6/NLRP3	3
BP	GO:0005979	regulation of glycogen biosynthetic process	3/365	30/18862	0.019825832476054	0.0357575489936826	0.0137426696150529	MTOR/GSK3B/IGF1	3
BP	GO:0007020	microtubule nucleation	3/365	30/18862	0.019825832476054	0.0357575489936826	0.0137426696150529	MECP2/HSPA1B/HSPA1A	3
BP	GO:0010962	regulation of glucan biosynthetic process	3/365	30/18862	0.019825832476054	0.0357575489936826	0.0137426696150529	MTOR/GSK3B/IGF1	3
BP	GO:0033137	negative regulation of peptidyl-serine phosphorylation	3/365	30/18862	0.019825832476054	0.0357575489936826	0.0137426696150529	GADD45A/BAX/CAV1	3
BP	GO:0034694	response to prostaglandin	3/365	30/18862	0.019825832476054	0.0357575489936826	0.0137426696150529	GNRH1/EDN1/PPARG	3
BP	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	3/365	30/18862	0.019825832476054	0.0357575489936826	0.0137426696150529	RPS27A/IKBKG/CD14	3
BP	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	3/365	30/18862	0.019825832476054	0.0357575489936826	0.0137426696150529	SRC/EGFR/CCND1	3
BP	GO:0050901	leukocyte tethering or rolling	3/365	30/18862	0.019825832476054	0.0357575489936826	0.0137426696150529	VCAM1/LEP/CXCL12	3
BP	GO:0060292	long-term synaptic depression	3/365	30/18862	0.019825832476054	0.0357575489936826	0.0137426696150529	STXBP1/AGER/GRIA1	3
BP	GO:0061384	heart trabecula morphogenesis	3/365	30/18862	0.019825832476054	0.0357575489936826	0.0137426696150529	CHD7/NRG1/NOTCH1	3
BP	GO:0070102	interleukin-6-mediated signaling pathway	3/365	30/18862	0.019825832476054	0.0357575489936826	0.0137426696150529	SRC/IL6/STAT1	3
BP	GO:0070198	protein localization to chromosome, telomeric region	3/365	30/18862	0.019825832476054	0.0357575489936826	0.0137426696150529	ATM/BRCA2/TERT	3
BP	GO:0071295	cellular response to vitamin	3/365	30/18862	0.019825832476054	0.0357575489936826	0.0137426696150529	PPARG/LEP/BGLAP	3
BP	GO:0001954	positive regulation of cell-matrix adhesion	4/365	54/18862	0.0204180495535827	0.0367496806614345	0.0141239747690207	DAG1/GSK3B/KDR/VEGFA	4
BP	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis	4/365	54/18862	0.0204180495535827	0.0367496806614345	0.0141239747690207	AGTR1/BMP4/NGFR/VEGFA	4
BP	GO:0016447	somatic recombination of immunoglobulin gene segments	4/365	54/18862	0.0204180495535827	0.0367496806614345	0.0141239747690207	PTPRC/PRKDC/CD40LG/IL10	4
BP	GO:0043331	response to dsRNA	4/365	54/18862	0.0204180495535827	0.0367496806614345	0.0141239747690207	NFKBIA/MAPK1/MAPK3/CAV1	4
BP	GO:0070228	regulation of lymphocyte apoptotic process	4/365	54/18862	0.0204180495535827	0.0367496806614345	0.0141239747690207	CCL5/BMP4/BAX/IL10	4
BP	GO:0097479	synaptic vesicle localization	4/365	54/18862	0.0204180495535827	0.0367496806614345	0.0141239747690207	PINK1/LRRK2/SLC2A4/CDH2	4
BP	GO:1903533	regulation of protein targeting	5/365	81/18862	0.0204290807369591	0.0367568953514074	0.0141267475849284	HRAS/PINK1/HUWE1/LRRK2/ANK3	5
BP	GO:0009581	detection of external stimulus	7/365	142/18862	0.0206930467098332	0.0372190400272394	0.0143043632709319	CTNNB1/CXCR4/CXCL12/NGFR/KIT/CDH2/NTRK1	7
BP	GO:0031623	receptor internalization	6/365	111/18862	0.0209263163953221	0.0376256750302699	0.0144606449697013	SNCA/UBQLN2/DRD4/VEGFA/GRIA1/CAV1	6
BP	GO:0008286	insulin receptor signaling pathway	7/365	143/18862	0.0214106020986703	0.0383462720790205	0.0147375914452081	PIK3R2/IGF1R/GSK3B/SORL1/SRC/LEP/SOCS1	7
BP	GO:0009798	axis specification	5/365	82/18862	0.0214221695064752	0.0383462720790205	0.0147375914452081	DDIT3/NOTCH1/BMP4/AURKA/SHH	5
BP	GO:0002335	mature B cell differentiation	3/365	31/18862	0.021642348650341	0.0383462720790205	0.0147375914452081	XBP1/IL6/IL10	3
BP	GO:0002347	response to tumor cell	3/365	31/18862	0.021642348650341	0.0383462720790205	0.0147375914452081	HMGB1/TXNIP/HLA-DRB1	3
BP	GO:0007431	salivary gland development	3/365	31/18862	0.021642348650341	0.0383462720790205	0.0147375914452081	DAG1/FGFR2/SHH	3
BP	GO:0032228	regulation of synaptic transmission, GABAergic	3/365	31/18862	0.021642348650341	0.0383462720790205	0.0147375914452081	STXBP1/CLN3/CNR1	3
BP	GO:0034377	plasma lipoprotein particle assembly	3/365	31/18862	0.021642348650341	0.0383462720790205	0.0147375914452081	MFSD2A/APOE/ABCA1	3
BP	GO:0045761	regulation of adenylate cyclase activity	3/365	31/18862	0.021642348650341	0.0383462720790205	0.0147375914452081	EDNRB/NF1/CRHR1	3
BP	GO:0045920	negative regulation of exocytosis	3/365	31/18862	0.021642348650341	0.0383462720790205	0.0147375914452081	SNCA/NOTCH1/IL1RAPL1	3
BP	GO:0048566	embryonic digestive tract development	3/365	31/18862	0.021642348650341	0.0383462720790205	0.0147375914452081	GLI3/FGFR2/SHH	3
BP	GO:0060317	cardiac epithelial to mesenchymal transition	3/365	31/18862	0.021642348650341	0.0383462720790205	0.0147375914452081	RTN4/NOTCH1/BMP2	3
BP	GO:0099174	regulation of presynapse organization	3/365	31/18862	0.021642348650341	0.0383462720790205	0.0147375914452081	SNCA/APP/IL1RAPL1	3
BP	GO:1903146	regulation of autophagy of mitochondrion	3/365	31/18862	0.021642348650341	0.0383462720790205	0.0147375914452081	PINK1/HTT/ATP13A2	3
BP	GO:1905606	regulation of presynapse assembly	3/365	31/18862	0.021642348650341	0.0383462720790205	0.0147375914452081	SNCA/APP/IL1RAPL1	3
BP	GO:0002087	regulation of respiratory gaseous exchange by nervous system process	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	MECP2/NLGN3	2
BP	GO:0002328	pro-B cell differentiation	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	PRKDC/NOTCH1	2
BP	GO:0002863	positive regulation of inflammatory response to antigenic stimulus	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	CNR1/C3	2
BP	GO:0003306	Wnt signaling pathway involved in heart development	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	CTNNB1/BMP2	2
BP	GO:0007638	mechanosensory behavior	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	HTT/NRXN1	2
BP	GO:0009086	methionine biosynthetic process	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	MTR/MTHFR	2
BP	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	SNCA/ADIPOQ	2
BP	GO:0014831	gastro-intestinal system smooth muscle contraction	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	KIT/GHRL	2
BP	GO:0021694	cerebellar Purkinje cell layer formation	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	ATP7A/RORA	2
BP	GO:0021984	adenohypophysis development	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	SOX2/BMP2	2
BP	GO:0032429	regulation of phospholipase A2 activity	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	AGTR1/EGFR	2
BP	GO:0035641	locomotory exploration behavior	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	LRRK2/APOE	2
BP	GO:0042178	xenobiotic catabolic process	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	GSTM1/CYP1A1	2
BP	GO:0043471	regulation of cellular carbohydrate catabolic process	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	SCARB2/HMGB1	2
BP	GO:0044650	adhesion of symbiont to host cell	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	HSP90AB1/ICAM1	2
BP	GO:0046322	negative regulation of fatty acid oxidation	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	MFSD2A/CNR1	2
BP	GO:0048266	behavioral response to pain	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	THBS4/NTRK1	2
BP	GO:0048548	regulation of pinocytosis	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	CLN3/CAV1	2
BP	GO:0048711	positive regulation of astrocyte differentiation	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	NOTCH1/BMP2	2
BP	GO:0051001	negative regulation of nitric-oxide synthase activity	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	CNR1/CAV1	2
BP	GO:0051549	positive regulation of keratinocyte migration	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	MMP9/MTOR	2
BP	GO:0060670	branching involved in labyrinthine layer morphogenesis	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	FGFR2/IL10	2
BP	GO:0061469	regulation of type B pancreatic cell proliferation	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	NUPR1/NR4A1	2
BP	GO:0072015	glomerular visceral epithelial cell development	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	BMP4/ADIPOQ	2
BP	GO:0086067	AV node cell to bundle of His cell communication	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	RYR2/SCN5A	2
BP	GO:0090677	reversible differentiation	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	DNMT1/SOD2	2
BP	GO:0097201	negative regulation of transcription from RNA polymerase II promoter in response to stress	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	JUN/HSPA1A	2
BP	GO:0098911	regulation of ventricular cardiac muscle cell action potential	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	RYR2/CAV1	2
BP	GO:1902950	regulation of dendritic spine maintenance	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	APOE/GRIN2B	2
BP	GO:1905245	regulation of aspartic-type peptidase activity	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	SORL1/AGER	2
BP	GO:1905907	negative regulation of amyloid fibril formation	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	APOE/CLU	2
BP	GO:2000727	positive regulation of cardiac muscle cell differentiation	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	MEF2C/BMP4	2
BP	GO:2001171	positive regulation of ATP biosynthetic process	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	PINK1/PPARA	2
BP	GO:2001204	regulation of osteoclast development	2/365	12/18862	0.0216822713013743	0.0383462720790205	0.0147375914452081	TNFSF11/FBN1	2
BP	GO:0001912	positive regulation of leukocyte mediated cytotoxicity	4/365	55/18862	0.0216934107042376	0.0383462720790205	0.0147375914452081	PTPRC/B2M/HLA-DRB1/NOS2	4
BP	GO:0016233	telomere capping	4/365	55/18862	0.0216934107042376	0.0383462720790205	0.0147375914452081	PRKDC/MAPK1/ATM/MAPK3	4
BP	GO:2000736	regulation of stem cell differentiation	6/365	112/18862	0.0217638312994582	0.0384577626675774	0.0147804405320959	EIF2AK2/PRKDC/KMT2A/GATA4/NOTCH1/GDNF	6
BP	GO:0060968	regulation of gene silencing	7/365	144/18862	0.0221452590410504	0.0391055111206939	0.0150293891663106	AGO1/AGO2/PPARG/EGFR/IL6/BMP4/TERT	7
BP	GO:0043433	negative regulation of DNA-binding transcription factor activity	8/365	177/18862	0.0221453448532168	0.0391055111206939	0.0150293891663106	KLF4/NFKBIA/NUPR1/HDAC4/DDIT3/NLRP3/CDKN2A/IL10	8
BP	GO:0005976	polysaccharide metabolic process	6/365	113/18862	0.0226236974673936	0.0399232746272212	0.0153436795472155	MTOR/GSK3B/HMGB1/LEPR/IGF1/POMC	6
BP	GO:0008543	fibroblast growth factor receptor signaling pathway	6/365	113/18862	0.0226236974673936	0.0399232746272212	0.0153436795472155	HNRNPA1/SETX/MAPK1/MAPK3/FGFR2/NGFR	6
BP	GO:0022900	electron transport chain	8/365	178/18862	0.0228123858272534	0.0402426786045986	0.0154664358171044	CYBB/NDUFS4/PINK1/SNCA/ALDH2/CYP19A1/NOX4/XDH	8
BP	GO:0009582	detection of abiotic stimulus	7/365	145/18862	0.0228971956449479	0.0403514888907938	0.0155082547855735	CTNNB1/CXCR4/CXCL12/NGFR/KIT/CDH2/NTRK1	7
BP	GO:0021915	neural tube development	7/365	145/18862	0.0228971956449479	0.0403514888907938	0.0155082547855735	LRP2/GLI3/MED12/MTHFR/NOTCH1/BMP4/SHH	7
BP	GO:0048284	organelle fusion	7/365	145/18862	0.0228971956449479	0.0403514888907938	0.0155082547855735	STXBP1/ATP13A2/CLN3/HUWE1/SNCA/SPG7/BAX	7
BP	GO:0019748	secondary metabolic process	4/365	56/18862	0.0230164575118644	0.0405071078066908	0.0155680636764849	BCL2/ZEB2/CYP2D6/CYP1A1	4
BP	GO:0046456	icosanoid biosynthetic process	4/365	56/18862	0.0230164575118644	0.0405071078066908	0.0155680636764849	EDN1/MIF/PTGS1/PLA2G4A	4
BP	GO:0097035	regulation of membrane lipid distribution	4/365	56/18862	0.0230164575118644	0.0405071078066908	0.0155680636764849	MFSD2A/P2RX7/ABCA1/FASLG	4
BP	GO:1902808	positive regulation of cell cycle G1/S phase transition	4/365	56/18862	0.0230164575118644	0.0405071078066908	0.0155680636764849	EGFR/CCND1/TERT/CYP1A1	4
BP	GO:0032392	DNA geometric change	6/365	114/18862	0.0235061455622063	0.041355013738685	0.0158939386711636	RPS27A/PARP1/PURA/SETX/CHD7/HMGB1	6
BP	GO:0016486	peptide hormone processing	3/365	32/18862	0.0235468135072811	0.0413709371927188	0.0159000585192538	NGF/FURIN/MME	3
BP	GO:0070884	regulation of calcineurin-NFAT signaling cascade	3/365	32/18862	0.0235468135072811	0.0413709371927188	0.0159000585192538	MTOR/GSK3B/IGF1	3
BP	GO:0071312	cellular response to alkaloid	3/365	32/18862	0.0235468135072811	0.0413709371927188	0.0159000585192538	ICAM1/RYR2/CASQ2	3
BP	GO:0071353	cellular response to interleukin-4	3/365	32/18862	0.0235468135072811	0.0413709371927188	0.0159000585192538	XBP1/HSP90AB1/IL24	3
BP	GO:0019083	viral transcription	8/365	180/18862	0.0241887196404513	0.0424702309956801	0.0163225492091677	CCL5/RPS27A/RPS6/EP300/RPL5/TARDBP/SP1/JUN	8
BP	GO:0031345	negative regulation of cell projection organization	8/365	180/18862	0.0241887196404513	0.0424702309956801	0.0163225492091677	SPP1/RTN4/LRRK2/APOE/B2M/NGFR/GRIN2B/TRPV4	8
BP	GO:0031295	T cell costimulation	4/365	57/18862	0.0243875589754017	0.0427763015004198	0.0164401810364021	SRC/CTLA4/CAV1/CD40LG	4
BP	GO:0032387	negative regulation of intracellular transport	4/365	57/18862	0.0243875589754017	0.0427763015004198	0.0164401810364021	TXN/UBE2J1/LRRK2/ADIPOQ	4
BP	GO:0051785	positive regulation of nuclear division	4/365	57/18862	0.0243875589754017	0.0427763015004198	0.0164401810364021	EDN1/IGF1/PDGFRB/AURKA	4
BP	GO:0006470	protein dephosphorylation	12/365	325/18862	0.0250182674742064	0.0436903133546957	0.0167914624662276	PTPRC/BCL2/EIF2AK2/PINK1/HTT/MTOR/HSP90AB1/GSK3B/DMPK/LRRK2/PPP1R15A/PDGFRB	12
BP	GO:0002551	mast cell chemotaxis	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	KIT/VEGFA	2
BP	GO:0002674	negative regulation of acute inflammatory response	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	PPARG/NLRP3	2
BP	GO:0002679	respiratory burst involved in defense response	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	PIK3CG/MPO	2
BP	GO:0005513	detection of calcium ion	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	RYR2/CASQ2	2
BP	GO:0006995	cellular response to nitrogen starvation	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	GABARAP/MAP1LC3A	2
BP	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	ADRB2/NRG1	2
BP	GO:0007494	midgut development	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	EDNRB/EGFR	2
BP	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	ATP1A1/BAX	2
BP	GO:0014745	negative regulation of muscle adaptation	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	KLF4/MTOR	2
BP	GO:0016322	neuron remodeling	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	APP/C3	2
BP	GO:0019336	phenol-containing compound catabolic process	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	MAOA/DBH	2
BP	GO:0031282	regulation of guanylate cyclase activity	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	NOS2/NOS1	2
BP	GO:0032096	negative regulation of response to food	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	PPARA/LEP	2
BP	GO:0032099	negative regulation of appetite	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	PPARA/LEP	2
BP	GO:0032105	negative regulation of response to extracellular stimulus	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	PPARA/LEP	2
BP	GO:0032108	negative regulation of response to nutrient levels	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	PPARA/LEP	2
BP	GO:0032274	gonadotropin secretion	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	GJA1/LEP	2
BP	GO:0033127	regulation of histone phosphorylation	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	ATM/MAPK3	2
BP	GO:0033604	negative regulation of catecholamine secretion	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	CNR1/P2RY12	2
BP	GO:0033689	negative regulation of osteoblast proliferation	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	BCL2/EIF2AK2	2
BP	GO:0033700	phospholipid efflux	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	APOE/ABCA1	2
BP	GO:0034982	mitochondrial protein processing	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	SPG7/LRRK2	2
BP	GO:0035745	T-helper 2 cell cytokine production	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	IL6/NLRP3	2
BP	GO:0035810	positive regulation of urine volume	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	EDNRB/EDN1	2
BP	GO:0035815	positive regulation of renal sodium excretion	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	EDNRB/EDN1	2
BP	GO:0042415	norepinephrine metabolic process	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	ATP7A/DBH	2
BP	GO:0042921	glucocorticoid receptor signaling pathway	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	ARNTL/CLOCK	2
BP	GO:0043562	cellular response to nitrogen levels	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	GABARAP/MAP1LC3A	2
BP	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	AR/IGF1	2
BP	GO:0043970	histone H3-K9 acetylation	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	KMT2A/BRCA1	2
BP	GO:0060080	inhibitory postsynaptic potential	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	NLGN3/DRD4	2
BP	GO:0060100	positive regulation of phagocytosis, engulfment	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	PPARG/C3	2
BP	GO:0060576	intestinal epithelial cell development	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	SRC/CDKN1A	2
BP	GO:0060841	venous blood vessel development	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	NOTCH1/VEGFA	2
BP	GO:0071415	cellular response to purine-containing compound	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	RYR2/CASQ2	2
BP	GO:0071599	otic vesicle development	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	COL2A1/FGFR2	2
BP	GO:0072182	regulation of nephron tubule epithelial cell differentiation	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	CTNNB1/STAT1	2
BP	GO:0072310	glomerular epithelial cell development	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	BMP4/ADIPOQ	2
BP	GO:0072683	T cell extravasation	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	ICAM1/CCL2	2
BP	GO:0098814	spontaneous synaptic transmission	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	AGER/APP	2
BP	GO:0099640	axo-dendritic protein transport	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	PURA/HSPB1	2
BP	GO:1904294	positive regulation of ERAD pathway	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	UBQLN2/CAV1	2
BP	GO:1904925	positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	PINK1/HUWE1	2
BP	GO:1904995	negative regulation of leukocyte adhesion to vascular endothelial cell	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	KLF4/CXCL12	2
BP	GO:1905155	positive regulation of membrane invagination	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	PPARG/C3	2
BP	GO:2000009	negative regulation of protein localization to cell surface	2/365	13/18862	0.0253009819981052	0.0436903133546957	0.0167914624662276	NEDD4L/ASTN2	2
BP	GO:0006356	regulation of transcription by RNA polymerase I	3/365	33/18862	0.025539189190225	0.0439421815324253	0.0168882627573688	MTOR/ATF4/PHF8	3
BP	GO:0019228	neuronal action potential	3/365	33/18862	0.025539189190225	0.0439421815324253	0.0168882627573688	ANK3/KCNA2/SCN5A	3
BP	GO:0032728	positive regulation of interferon-beta production	3/365	33/18862	0.025539189190225	0.0439421815324253	0.0168882627573688	HSP90AA1/HMGB1/TLR2	3
BP	GO:0035909	aorta morphogenesis	3/365	33/18862	0.025539189190225	0.0439421815324253	0.0168882627573688	CHD7/NOTCH1/PDGFRB	3
BP	GO:0048536	spleen development	3/365	33/18862	0.025539189190225	0.0439421815324253	0.0168882627573688	BCL2/PRKDC/BCL2L11	3
BP	GO:0050869	negative regulation of B cell activation	3/365	33/18862	0.025539189190225	0.0439421815324253	0.0168882627573688	ATM/CTLA4/IL10	3
BP	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	3/365	33/18862	0.025539189190225	0.0439421815324253	0.0168882627573688	EDN1/AGTR1/HTR2C	3
BP	GO:0060323	head morphogenesis	3/365	33/18862	0.025539189190225	0.0439421815324253	0.0168882627573688	EP300/DLX5/MMP2	3
BP	GO:0106056	regulation of calcineurin-mediated signaling	3/365	33/18862	0.025539189190225	0.0439421815324253	0.0168882627573688	MTOR/GSK3B/IGF1	3
BP	GO:0140448	signaling receptor ligand precursor processing	3/365	33/18862	0.025539189190225	0.0439421815324253	0.0168882627573688	NGF/FURIN/MME	3
BP	GO:1901020	negative regulation of calcium ion transmembrane transporter activity	3/365	33/18862	0.025539189190225	0.0439421815324253	0.0168882627573688	DRD4/CASQ2/CRHR1	3
BP	GO:0007051	spindle organization	8/365	182/18862	0.0256222845733028	0.0440706662690327	0.0169376431913041	SMC1A/MECP2/DYNC1H1/WDR62/SPAST/HSPA1B/HSPA1A/AURKA	8
BP	GO:0030901	midbrain development	5/365	86/18862	0.0257066956333024	0.0441723062851953	0.0169767064157449	PLP1/CTNNB1/ZNF148/FGFR2/SHH	5
BP	GO:0034637	cellular carbohydrate biosynthetic process	5/365	86/18862	0.0257066956333024	0.0441723062851953	0.0169767064157449	MTOR/GSK3B/SLC2A1/LEP/IGF1	5
BP	GO:0051781	positive regulation of cell division	5/365	86/18862	0.0257066956333024	0.0441723062851953	0.0169767064157449	SPAST/FGFR2/THBS4/VEGFA/SHH	5
BP	GO:0031294	lymphocyte costimulation	4/365	59/18862	0.0272752286866926	0.046836793617503	0.0180007466570899	SRC/CTLA4/CAV1/CD40LG	4
BP	GO:0051055	negative regulation of lipid biosynthetic process	4/365	59/18862	0.0272752286866926	0.046836793617503	0.0180007466570899	ATP1A1/BRCA1/APOE/BMP2	4
BP	GO:0002756	MyD88-independent toll-like receptor signaling pathway	3/365	34/18862	0.0276193292235616	0.047195419247836	0.0181385769528417	RPS27A/IKBKG/CD14	3
BP	GO:0010543	regulation of platelet activation	3/365	34/18862	0.0276193292235616	0.047195419247836	0.0181385769528417	APOE/PRKCA/PLA2G4A	3
BP	GO:0010614	negative regulation of cardiac muscle hypertrophy	3/365	34/18862	0.0276193292235616	0.047195419247836	0.0181385769528417	TNFRSF1A/PPARA/NOTCH1	3
BP	GO:0014904	myotube cell development	3/365	34/18862	0.0276193292235616	0.047195419247836	0.0181385769528417	BCL2/HDAC4/IGF1	3
BP	GO:0021532	neural tube patterning	3/365	34/18862	0.0276193292235616	0.047195419247836	0.0181385769528417	GLI3/BMP4/SHH	3
BP	GO:0030513	positive regulation of BMP signaling pathway	3/365	34/18862	0.0276193292235616	0.047195419247836	0.0181385769528417	GATA4/NOTCH1/BMP4	3
BP	GO:0031646	positive regulation of nervous system process	3/365	34/18862	0.0276193292235616	0.047195419247836	0.0181385769528417	DAG1/MTOR/DICER1	3
BP	GO:0033280	response to vitamin D	3/365	34/18862	0.0276193292235616	0.047195419247836	0.0181385769528417	SPP1/CD4/BGLAP	3
BP	GO:0045922	negative regulation of fatty acid metabolic process	3/365	34/18862	0.0276193292235616	0.047195419247836	0.0181385769528417	MFSD2A/BRCA1/CNR1	3
BP	GO:0051567	histone H3-K9 methylation	3/365	34/18862	0.0276193292235616	0.047195419247836	0.0181385769528417	MECP2/DNMT1/BRCA1	3
BP	GO:0060428	lung epithelium development	3/365	34/18862	0.0276193292235616	0.047195419247836	0.0181385769528417	FGFR2/BMP4/SHH	3
BP	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	3/365	34/18862	0.0276193292235616	0.047195419247836	0.0181385769528417	AKT3/KDR/VEGFA	3
BP	GO:0098664	G protein-coupled serotonin receptor signaling pathway	3/365	34/18862	0.0276193292235616	0.047195419247836	0.0181385769528417	DRD4/CHRM3/HTR2C	3
BP	GO:1901385	regulation of voltage-gated calcium channel activity	3/365	34/18862	0.0276193292235616	0.047195419247836	0.0181385769528417	NPPA/DRD4/CRHR1	3
BP	GO:2000758	positive regulation of peptidyl-lysine acetylation	3/365	34/18862	0.0276193292235616	0.047195419247836	0.0181385769528417	MAPK3/BRCA1/NOS1	3
BP	GO:0008360	regulation of cell shape	7/365	151/18862	0.0277812515448271	0.0474566157263789	0.0182389623822195	DAG1/ICAM1/KDR/CCL2/KIT/VEGFA/FN1	7
BP	GO:0001708	cell fate specification	5/365	88/18862	0.0280402607981426	0.047883433937187	0.0184030010767581	GLI3/SOX2/NOTCH1/AR/SHH	5
BP	GO:0045576	mast cell activation	4/365	60/18862	0.0287923627175778	0.049019562042377	0.0188396482639789	STXBP1/PIK3CG/KIT/CNR1	4
BP	GO:0048857	neural nucleus development	4/365	60/18862	0.0287923627175778	0.049019562042377	0.0188396482639789	PLP1/BCL2/ZNF148/FOXP2	4
BP	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	4/365	60/18862	0.0287923627175778	0.049019562042377	0.0188396482639789	HRAS/DAG1/DRD4/ADAM10	4
BP	GO:0001780	neutrophil homeostasis	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	HMGB1/IL6	2
BP	GO:0002864	regulation of acute inflammatory response to antigenic stimulus	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	CNR1/C3	2
BP	GO:0003188	heart valve formation	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	GATA4/NOTCH1	2
BP	GO:0003214	cardiac left ventricle morphogenesis	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	NOTCH1/RYR2	2
BP	GO:0006878	cellular copper ion homeostasis	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	ATP7A/APP	2
BP	GO:0007635	chemosensory behavior	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	CHD7/NTRK1	2
BP	GO:0009415	response to water	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	KRT8/NTRK1	2
BP	GO:0010896	regulation of triglyceride catabolic process	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	SORL1/PIK3CG	2
BP	GO:0030252	growth hormone secretion	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	CHD7/GHRL	2
BP	GO:0030575	nuclear body organization	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	ETS1/AFF2	2
BP	GO:0031958	corticosteroid receptor signaling pathway	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	ARNTL/CLOCK	2
BP	GO:0032488	Cdc42 protein signal transduction	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	APOE/ABCA1	2
BP	GO:0032799	low-density lipoprotein receptor particle metabolic process	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	FURIN/APOE	2
BP	GO:0032802	low-density lipoprotein particle receptor catabolic process	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	FURIN/APOE	2
BP	GO:0032966	negative regulation of collagen biosynthetic process	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	PPARG/IL6	2
BP	GO:0034349	glial cell apoptotic process	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	PRKCA/CCL2	2
BP	GO:0035791	platelet-derived growth factor receptor-beta signaling pathway	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	SRC/PDGFRB	2
BP	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	ATM/PIK3CG	2
BP	GO:0043374	CD8-positive, alpha-beta T cell differentiation	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	BCL2/SOCS1	2
BP	GO:0044065	regulation of respiratory system process	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	MECP2/NLGN3	2
BP	GO:0044794	positive regulation by host of viral process	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	APOE/PPIB	2
BP	GO:0045059	positive thymic T cell selection	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	PTPRC/SHH	2
BP	GO:0045475	locomotor rhythm	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	MTOR/EGR1	2
BP	GO:0051290	protein heterotetramerization	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	GRIN1/GRIN2B	2
BP	GO:0051547	regulation of keratinocyte migration	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	MMP9/MTOR	2
BP	GO:0051589	negative regulation of neurotransmitter transport	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	SNCA/NOS1	2
BP	GO:0060253	negative regulation of glial cell proliferation	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	DICER1/NOTCH1	2
BP	GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	PRL/GHR	2
BP	GO:0060644	mammary gland epithelial cell differentiation	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	CEBPB/ERBB4	2
BP	GO:0070672	response to interleukin-15	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	CD4/ACSL4	2
BP	GO:0072425	signal transduction involved in G2 DNA damage checkpoint	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	ATM/BRCA1	2
BP	GO:0072672	neutrophil extravasation	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	PIK3CG/IL1R1	2
BP	GO:0086103	G protein-coupled receptor signaling pathway involved in heart process	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	SRC/CAV1	2
BP	GO:0090128	regulation of synapse maturation	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	NRXN1/RELN	2
BP	GO:0090308	regulation of DNA methylation-dependent heterochromatin assembly	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	DNMT1/TET1	2
BP	GO:0097531	mast cell migration	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	KIT/VEGFA	2
BP	GO:0099170	postsynaptic modulation of chemical synaptic transmission	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	EIF4E/GHRL	2
BP	GO:1901096	regulation of autophagosome maturation	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	CLN3/ADRB2	2
BP	GO:1901160	primary amino compound metabolic process	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	ATP7A/GRIN2A	2
BP	GO:1901386	negative regulation of voltage-gated calcium channel activity	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	DRD4/CRHR1	2
BP	GO:1903894	regulation of IRE1-mediated unfolded protein response	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	BCL2L11/BAX	2
BP	GO:1904923	regulation of autophagy of mitochondrion in response to mitochondrial depolarization	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	PINK1/HUWE1	2
BP	GO:1905065	positive regulation of vascular associated smooth muscle cell differentiation	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	KIT/SOD2	2
BP	GO:1905208	negative regulation of cardiocyte differentiation	2/365	14/18862	0.029145754122254	0.049019562042377	0.0188396482639789	EGFR/BMP2	2
BP	GO:1901532	regulation of hematopoietic progenitor cell differentiation	5/365	89/18862	0.029255773340833	0.0491887946244522	0.0189046892840996	EIF2AK2/PRKDC/KMT2A/NOTCH1/KITLG	5
BP	GO:0043244	regulation of protein-containing complex disassembly	6/365	120/18862	0.0292871785957394	0.0492257844476879	0.0189189055526681	IGF1R/CLN3/SETX/SPAST/ADRB2/TRPV4	6
BP	GO:0001825	blastocyst formation	3/365	35/18862	0.0297869841774371	0.0499535646218219	0.0191986127128897	RTN4/FURIN/TET1	3
BP	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	3/365	35/18862	0.0297869841774371	0.0499535646218219	0.0191986127128897	RPS27A/CD14/TLR2	3
BP	GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway	3/365	35/18862	0.0297869841774371	0.0499535646218219	0.0191986127128897	ARNTL/CLOCK/BRCA1	3
BP	GO:0060236	regulation of mitotic spindle organization	3/365	35/18862	0.0297869841774371	0.0499535646218219	0.0191986127128897	DYNC1H1/HSPA1B/HSPA1A	3
BP	GO:0065005	protein-lipid complex assembly	3/365	35/18862	0.0297869841774371	0.0499535646218219	0.0191986127128897	MFSD2A/APOE/ABCA1	3
BP	GO:0070670	response to interleukin-4	3/365	35/18862	0.0297869841774371	0.0499535646218219	0.0191986127128897	XBP1/HSP90AB1/IL24	3
BP	GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	3/365	35/18862	0.0297869841774371	0.0499535646218219	0.0191986127128897	BCL2/GSK3B/BAX	3
CC	GO:0045121	membrane raft	38/365	323/19520	1.18242303496041e-19	2.87328797495378e-17	1.66783880720731e-17	EDNRB/PTPRC/CD4/DAG1/ATP1A1/PSEN2/ATP7A/CLN3/TNFRSF1A/GJA1/ICAM1/MAPK1/CD14/MAPK3/SRC/LAMP2/EGFR/SLC2A1/FURIN/FAS/LRRK2/KDR/ABCA1/FASLG/CTSD/TLR2/KCNQ1/APP/SLC2A4/CDH2/CNR1/MME/CAV1/SCN5A/P2RY12/NOS1/SHH/SLC6A4	38
CC	GO:0098857	membrane microdomain	38/365	323/19520	1.18242303496041e-19	2.87328797495378e-17	1.66783880720731e-17	EDNRB/PTPRC/CD4/DAG1/ATP1A1/PSEN2/ATP7A/CLN3/TNFRSF1A/GJA1/ICAM1/MAPK1/CD14/MAPK3/SRC/LAMP2/EGFR/SLC2A1/FURIN/FAS/LRRK2/KDR/ABCA1/FASLG/CTSD/TLR2/KCNQ1/APP/SLC2A4/CDH2/CNR1/MME/CAV1/SCN5A/P2RY12/NOS1/SHH/SLC6A4	38
CC	GO:0005788	endoplasmic reticulum lumen	34/365	306/19520	6.42229327546017e-17	1.04041151062455e-14	6.03920911516956e-15	COL2A1/SPP1/EDN1/CD4/DAG1/UGGT1/DNAJC3/MANF/BCHE/SERPINA1/CST3/TF/APOE/B2M/CANX/IL6/PPIB/DNAJC10/BGLAP/BMP4/C4A/CP/GHRL/APP/CLU/CASQ2/CDH2/ADAM10/FBN1/FN1/COL9A2/C3/SHH/PROC	34
CC	GO:0031983	vesicle lumen	31/365	328/19520	1.37713656126946e-13	1.67322092194239e-11	9.71243680053198e-12	MIF/EEF1A1/DNAJC3/HSP90AA1/HSP90AB1/MAN2B1/DYNC1H1/HUWE1/MAPK1/EGFR/HMGB1/SERPINA1/TF/B2M/SERPINA3/FASLG/CTSD/GHRL/APP/SERPINI1/IGF1/SERPINE1/CLU/TTR/POMC/VEGFA/FN1/C3/HP/DBH/MPO	31
CC	GO:0043025	neuronal cell body	37/365	474/19520	2.12760740362268e-13	2.06803439632124e-11	1.20041849299132e-11	NPPA/L1CAM/CYBB/GNRH1/SMN1/SORT1/HCFC1/PSEN2/PURA/ATP7A/ATP13A2/PMM2/MTOR/HSP90AA1/HSP90AB1/RTN4/MAPK1/SNCA/LRRK2/APOE/BGLAP/C4A/NGFR/APP/ASTN2/ACSL4/SERPINI1/AURKA/KCNA2/ADAM10/NTRK1/GJC2/MME/GRIA1/SLC6A1/NRXN1/NQO1	37
CC	GO:0060205	cytoplasmic vesicle lumen	30/365	326/19520	6.93557358236301e-13	5.61781460171404e-11	3.26093635100577e-11	MIF/EEF1A1/DNAJC3/HSP90AA1/HSP90AB1/MAN2B1/DYNC1H1/HUWE1/MAPK1/HMGB1/SERPINA1/TF/B2M/SERPINA3/FASLG/CTSD/GHRL/APP/SERPINI1/IGF1/SERPINE1/CLU/TTR/POMC/VEGFA/FN1/C3/HP/DBH/MPO	30
CC	GO:0030139	endocytic vesicle	29/365	307/19520	8.82947977481303e-13	6.13018167222733e-11	3.55834673631563e-11	HBA1/LRP2/CYBB/OCLN/RPS27A/STXBP1/ATP7A/SCARB2/MTOR/HSP90AA1/LAMP2/EGFR/CTLA4/TF/APOE/HLA-DQA1/B2M/HBB/ABCA1/NLGN3/TLR2/SFTPB/HLA-DRB1/CAMK2A/GRIA1/CAV1/HLA-DQB1/HP/MPO	29
CC	GO:0034774	secretory granule lumen	29/365	322/19520	2.91676596883405e-12	1.77193532606669e-10	1.0285437890099e-10	MIF/EEF1A1/DNAJC3/HSP90AA1/HSP90AB1/MAN2B1/DYNC1H1/HUWE1/MAPK1/HMGB1/SERPINA1/TF/B2M/SERPINA3/CTSD/GHRL/APP/SERPINI1/IGF1/SERPINE1/CLU/TTR/POMC/VEGFA/FN1/C3/HP/DBH/MPO	29
CC	GO:0005770	late endosome	25/365	275/19520	7.94169868262861e-11	4.27006080396145e-09	2.47861445843983e-09	MAP1LC3A/NEDD4L/HTT/ATP7A/ATP13A2/CLN3/SCARB2/SORL1/GJA1/MAPK1/MAPK3/SRC/LAMP2/DDIT3/EGFR/TF/CXCR4/LRRK2/KCNQ1/SFTPB/ASTN2/HLA-DRB1/SLC2A4/NTRK1/GRIN2B	25
CC	GO:0030136	clathrin-coated vesicle	21/365	192/19520	8.78613334148447e-11	4.27006080396145e-09	2.47861445843983e-09	LRP2/SORT1/EDN1/CD4/ATP7A/SCARB2/DNAJC5/CFTR/EGFR/CTLA4/ADRB2/FURIN/TF/APOE/HLA-DQA1/SFTPB/ASTN2/HLA-DRB1/SLC2A4/ADAM10/HLA-DQB1	21
CC	GO:0030135	coated vesicle	25/365	295/19520	3.53678629350614e-10	1.56261648967635e-08	9.0704184369344e-09	LRP2/SORT1/EDN1/CD4/ATP7A/SCARB2/DNAJC5/CFTR/EGFR/CTLA4/SERPINA1/ADRB2/FURIN/TF/APOE/HLA-DQA1/B2M/SFTPB/APP/ASTN2/HLA-DRB1/SLC2A4/ADAM10/GRIA1/HLA-DQB1	25
CC	GO:0005769	early endosome	27/365	378/19520	3.0167268052425e-09	1.22177435612321e-07	7.09195424390342e-08	SORT1/CD4/HTT/CLN3/SORL1/GJA1/MAPK1/ANK2/MAPK3/SLC9A6/CFTR/EGFR/HMGB1/VCAM1/ADRB2/TF/CXCR4/APOE/B2M/KDR/KCNQ1/APP/ASTN2/NTRK1/MME/GRIA1/CAV1	27
CC	GO:1904813	ficolin-1-rich granule lumen	15/365	124/19520	1.12895254888165e-08	4.22054568274219e-07	2.44987273765412e-07	MMP9/MIF/EEF1A1/HSP90AA1/HSP90AB1/HUWE1/MAPK1/HMGB1/SERPINA1/CST3/HBB/HSPA1B/CTSD/HSPA1A/CTSB	15
CC	GO:0072562	blood microparticle	16/365	146/19520	1.54046285015772e-08	5.34760675126178e-07	3.10409055520502e-07	HBA1/BCHE/SLC2A1/TF/APOE/HBB/SERPINA3/HSPA1B/C4A/CP/HSPA1A/AGT/CLU/FN1/C3/HP	16
CC	GO:0062023	collagen-containing extracellular matrix	27/365	423/19520	3.24435734038731e-08	1.05117177828549e-06	6.10166854192139e-07	COL2A1/NPPA/MMP9/L1CAM/DAG1/ICAM1/SERPINA1/APOE/ELN/SERPINA3/CXCL12/FGFR2/CTSD/THBS4/MMP2/SERPINE1/AGT/CLU/CDH2/ADIPOQ/CTSB/GDF15/FBN1/FN1/COL9A2/SHH/MBL2	27
CC	GO:0044853	plasma membrane raft	13/365	111/19520	1.59018089886223e-07	4.83017448029403e-06	2.80374000588867e-06	DAG1/ATP1A1/CLN3/MAPK1/MAPK3/SRC/SLC2A1/LRRK2/FASLG/CDH2/CAV1/SCN5A/P2RY12	13
CC	GO:0005775	vacuolar lumen	16/365	173/19520	1.68964675090299e-07	4.83040188787562e-06	2.80387200769042e-06	DNAJC3/ATP13A2/SCARB2/HSP90AA1/MAN2B1/DYNC1H1/MAPK1/LAMP2/SERPINA3/FASLG/CTSD/PDGFRB/TTR/CTSB/C3/MPO	16
CC	GO:0016528	sarcoplasm	11/365	79/19520	2.43817567850388e-07	6.58307433196048e-06	3.82123439671953e-06	MEF2C/MANF/DMPK/ANK3/THBS4/ITPR1/RYR2/SLC2A4/CASQ2/XDH/NOS1	11
CC	GO:0005901	caveola	11/365	80/19520	2.78010991428758e-07	7.11122851759876e-06	4.12780862619984e-06	ATP1A1/CLN3/MAPK1/MAPK3/SRC/SLC2A1/LRRK2/FASLG/CAV1/SCN5A/P2RY12	11
CC	GO:0005925	focal adhesion	25/365	416/19520	3.32243323736374e-07	8.07351276679389e-06	4.68637951375517e-06	L1CAM/PTPRC/DAG1/CTNNB1/RPL5/SCARB2/HSPB1/GJA1/ICAM1/MAPK1/MAPK3/SRC/EGFR/B2M/PPIB/HSPA1B/HSPA1A/PDGFRB/CDH2/ADAM10/NOX4/MME/CAV1/TRPV4/SLC6A4	25
CC	GO:0101002	ficolin-1-rich granule	16/365	185/19520	4.23010077668913e-07	9.78966179748056e-06	5.68254139424906e-06	MMP9/MIF/EEF1A1/HSP90AA1/HSP90AB1/HUWE1/MAPK1/LAMP2/HMGB1/SERPINA1/CST3/HBB/HSPA1B/CTSD/HSPA1A/CTSB	16
CC	GO:0030055	cell-substrate junction	25/365	423/19520	4.53202973056383e-07	1.00116656775183e-05	5.81140654445506e-06	L1CAM/PTPRC/DAG1/CTNNB1/RPL5/SCARB2/HSPB1/GJA1/ICAM1/MAPK1/MAPK3/SRC/EGFR/B2M/PPIB/HSPA1B/HSPA1A/PDGFRB/CDH2/ADAM10/NOX4/MME/CAV1/TRPV4/SLC6A4	25
CC	GO:0009897	external side of plasma membrane	24/365	402/19520	6.45677387210438e-07	1.30749670910114e-05	7.58954121808761e-06	LRP2/CCR5/FCGR3A/PTPRC/CD4/DAG1/ICAM1/CD14/IL1R1/CTLA4/VCAM1/FAS/TF/CXCR4/B2M/CXCL12/FASLG/KIT/LEPR/HLA-DRB1/SLC2A4/GHR/P2RY12/CD40LG	24
CC	GO:0030133	transport vesicle	24/365	402/19520	6.45677387210438e-07	1.30749670910114e-05	7.58954121808761e-06	SORT1/EDN1/ATP7A/ATP13A2/CLN3/DNAJC5/SORL1/NGF/FURIN/LRRK2/HLA-DQA1/B2M/GRIN1/ITPR1/APP/HLA-DRB1/IGF1/SLC2A4/ADAM10/MME/GRIA1/HLA-DQB1/GRIN2A/DBH	24
CC	GO:0016529	sarcoplasmic reticulum	10/365	70/19520	6.76461671029579e-07	1.3150414884815e-05	7.63333590888114e-06	MANF/DMPK/ANK3/THBS4/ITPR1/RYR2/SLC2A4/CASQ2/XDH/NOS1	10
CC	GO:0016324	apical plasma membrane	22/365	351/19520	8.50802177100363e-07	1.58051832193769e-05	9.17433203983757e-06	LRP2/OCLN/ATP1A1/PSEN2/ATP7A/HSP90AB1/GJA1/ANK2/CFTR/EGFR/AGER/SLC2A1/ADRB2/TF/NOTCH1/EPCAM/PDGFRB/CDH2/CTSB/NOX4/TRPV4/FN1	22
CC	GO:0005667	transcription regulator complex	24/365	409/19520	8.78065734409827e-07	1.58051832193769e-05	9.17433203983757e-06	KLF4/ARNTL/PARP1/CTNNB1/EP300/CLOCK/CEBPB/PRKDC/GLI3/ATF4/CREBBP/SP1/HDAC4/GATA4/PPARG/DDIT3/SOX2/HMGB1/FOS/CCND1/AHR/JUN/SATB2/NR4A1	24
CC	GO:0045177	apical part of cell	24/365	414/19520	1.08869082044637e-06	1.88965620977476e-05	1.09687646571288e-05	LRP2/OCLN/ATP1A1/PSEN2/ATP7A/HSP90AB1/GJA1/ANK2/CFTR/EGFR/AGER/SLC2A1/VCAM1/ADRB2/TF/NOTCH1/EPCAM/APP/PDGFRB/CDH2/CTSB/NOX4/TRPV4/FN1	24
CC	GO:0016234	inclusion body	10/365	74/19520	1.14645958716356e-06	1.89162562757417e-05	1.09801964087043e-05	PINK1/STUB1/HTT/HSP90AB1/ATF4/SNCA/LRRK2/HSPA1B/HSPA1A/CLU	10
CC	GO:0005798	Golgi-associated vesicle	11/365	92/19520	1.16767014047788e-06	1.89162562757417e-05	1.09801964087043e-05	GNRH1/SORT1/ATP7A/ITM2B/GJA1/CFTR/FURIN/LRRK2/APP/SLC2A4/ADAM10	11
CC	GO:0071682	endocytic vesicle lumen	6/365	20/19520	1.27409766524031e-06	1.99745633969933e-05	1.15945050690799e-05	HBA1/HSP90AA1/APOE/HBB/HP/MPO	6
CC	GO:0030426	growth cone	15/365	178/19520	1.35176450951596e-06	2.05299234882736e-05	1.19168713338907e-05	L1CAM/PINK1/PSEN2/USP9X/HSP90AA1/HSP90AB1/SETX/SNCA/DICER1/CDKL5/LRRK2/NGFR/APP/CNR1/TRPV4	15
CC	GO:0042383	sarcolemma	13/365	134/19520	1.42248668550059e-06	2.09493493682814e-05	1.21603327500529e-05	DAG1/ATP1A1/ANK2/SLC2A1/VCAM1/ANK3/KRT8/RYR2/SLC2A4/CDH2/CAV1/SCN5A/NOS1	13
CC	GO:0098978	glutamatergic synapse	20/365	308/19520	1.56680088128053e-06	2.23960361265393e-05	1.30000816155784e-05	STXBP1/HRAS/DAG1/PURA/MTOR/GSK3B/EIF4E/SRC/CDKL5/LRRK2/APOE/NLGN3/GHRL/DRD4/IL1RAPL1/CNR1/ADAM10/GRIA1/GRIN2A/ERBB4	20
CC	GO:0098793	presynapse	26/365	487/19520	1.80433838677204e-06	2.50545273134632e-05	1.45432387264633e-05	CEL/GNRH1/STXBP1/HTT/CLN3/DNAJC5/SNCA/NGF/SLC2A1/LRRK2/CANX/NLGN3/GRIN1/APP/SLC2A4/CDH2/CNR1/KCNA2/ADAM10/MME/GRIA1/SLC6A1/GRIN2A/NRXN1/SLC6A4/ERBB4	26
CC	GO:0030665	clathrin-coated vesicle membrane	12/365	117/19520	2.00774374285652e-06	2.69250000589502e-05	1.56289798912685e-05	LRP2/CD4/SCARB2/DNAJC5/CFTR/EGFR/ADRB2/TF/APOE/HLA-DQA1/HLA-DRB1/HLA-DQB1	12
CC	GO:0030427	site of polarized growth	15/365	184/19520	2.04984568350033e-06	2.69250000589502e-05	1.56289798912685e-05	L1CAM/PINK1/PSEN2/USP9X/HSP90AA1/HSP90AB1/SETX/SNCA/DICER1/CDKL5/LRRK2/NGFR/APP/CNR1/TRPV4	15
CC	GO:0005635	nuclear envelope	25/365	462/19520	2.2520872783145e-06	2.88030109805486e-05	1.67190966921963e-05	MATR3/EDNRB/CYBB/SORT1/BCL2/PARP1/PSEN2/ATF6/MTOR/PHF8/RTN4/P2RX7/SORL1/BCHE/MAPK3/SPAST/EGFR/CCND1/DMPK/ITPR1/BAX/APP/PLA2G4A/NR4A1/NRXN1	25
CC	GO:0030666	endocytic vesicle membrane	14/365	163/19520	2.42961266189833e-06	3.02767116328868e-05	1.75745261373482e-05	CYBB/RPS27A/ATP7A/SCARB2/LAMP2/APOE/HLA-DQA1/B2M/TLR2/HLA-DRB1/CAMK2A/GRIA1/CAV1/HLA-DQB1	14
CC	GO:0031904	endosome lumen	7/365	35/19520	3.23203966691067e-06	3.92692819529646e-05	2.27943850192647e-05	LRP2/NGF/B2M/SFTPB/APP/PRL/CTSB	7
CC	GO:0043204	perikaryon	13/365	151/19520	5.41683213521317e-06	6.42092784808196e-05	3.72711428045476e-05	NPPA/GNRH1/SMN1/ATP7A/MAPK1/LRRK2/BGLAP/NGFR/APP/ASTN2/SERPINI1/KCNA2/GJC2	13
CC	GO:0005774	vacuolar membrane	23/365	431/19520	7.23206138299315e-06	8.36852817174921e-05	4.85762518957936e-05	LRP2/OCLN/GABARAP/ABCD1/SORT1/MAP1LC3A/PSEN2/ZFYVE26/EEF1A1/ATP13A2/CLN3/SCARB2/DNAJC5/MTOR/HSP90AB1/MAN2B1/LAMP2/CFTR/HLA-DQA1/CTSD/CP/HLA-DRB1/HLA-DQB1	23
CC	GO:0031300	intrinsic component of organelle membrane	22/365	402/19520	7.7110002062586e-06	8.50125369858142e-05	4.93466751401304e-05	HSD11B1/ABCD1/BSCL2/PINK1/ATF6/ITM2B/ATP13A2/CLN3/DNAJC5/POMGNT1/RTN4/P2RX7/CYP2E1/LAMP2/FURIN/DMPK/HLA-DQA1/B2M/CANX/HLA-DRB1/CNR1/HLA-DQB1	22
CC	GO:0031091	platelet alpha granule	10/365	91/19520	7.7410126300191e-06	8.50125369858142e-05	4.93466751401304e-05	STXBP1/SNCA/SERPINA1/SERPINA3/APP/IGF1/SERPINE1/CLU/VEGFA/FN1	10
CC	GO:0045178	basal part of cell	17/365	258/19520	7.8715312023902e-06	8.50125369858142e-05	4.93466751401304e-05	EDN1/ATP1A1/CTNNB1/ATP7A/HSP90AB1/ANK2/EGFR/SLC2A1/TF/EPCAM/ANK3/KCNQ1/LEPR/CDH2/CHRM3/P2RY12/ERBB4	17
CC	GO:0150034	distal axon	18/365	287/19520	8.43615084973494e-06	8.91297676732865e-05	5.1736577293569e-05	L1CAM/GNRH1/PINK1/PSEN2/USP9X/HSP90AA1/HSP90AB1/SETX/SNCA/DICER1/CDKL5/LRRK2/GRIN1/NGFR/APP/CNR1/KCNA2/TRPV4	18
CC	GO:0030662	coated vesicle membrane	14/365	182/19520	8.78653644604276e-06	9.08565258037613e-05	5.27388973693048e-05	LRP2/CD4/SCARB2/DNAJC5/CFTR/EGFR/ADRB2/TF/APOE/HLA-DQA1/B2M/HLA-DRB1/GRIA1/HLA-DQB1	14
CC	GO:0009925	basal plasma membrane	16/365	240/19520	1.25650824867496e-05	0.00012722146017834	7.38474146151073e-05	ATP1A1/CTNNB1/ATP7A/HSP90AB1/ANK2/EGFR/SLC2A1/TF/EPCAM/ANK3/KCNQ1/LEPR/CDH2/CHRM3/P2RY12/ERBB4	16
CC	GO:0030018	Z disc	11/365	122/19520	1.85072221471917e-05	0.000183561427827248	0.000106550709676635	SMN1/PSEN2/STUB1/HDAC4/ANK2/SLC2A1/ANK3/KRT8/RYR2/CASQ2/SCN5A	11
CC	GO:0005771	multivesicular body	8/365	62/19520	1.94022983707849e-05	0.000188590340164029	0.000109469809755165	NEDD4L/ATP13A2/SORL1/GJA1/EGFR/LRRK2/SFTPB/SLC2A4	8
CC	GO:0044754	autolysosome	4/365	10/19520	2.31021152476316e-05	0.000220149568830372	0.000127788790224257	MAP1LC3A/CLN3/LAMP2/LRRK2	4
CC	GO:0031301	integral component of organelle membrane	20/365	371/19520	2.47895200382998e-05	0.000231686668050263	0.000134485655268509	HSD11B1/ABCD1/BSCL2/PINK1/ATF6/ITM2B/ATP13A2/CLN3/POMGNT1/RTN4/P2RX7/LAMP2/FURIN/DMPK/HLA-DQA1/B2M/CANX/HLA-DRB1/CNR1/HLA-DQB1	20
CC	GO:0014704	intercalated disc	7/365	48/19520	2.87214028207794e-05	0.000263369844733939	0.000152876583038111	ATP1A1/GJA1/ANK2/SLC2A1/ANK3/CDH2/SCN5A	7
CC	GO:0042470	melanosome	10/365	106/19520	2.99472484156761e-05	0.000264624776909429	0.00015360502536653	ATP1A1/DNAJC5/HSP90AA1/HSP90AB1/SLC2A1/PRDX1/CANX/PPIB/CTSD/CTSB	10
CC	GO:0048770	pigment granule	10/365	106/19520	2.99472484156761e-05	0.000264624776909429	0.00015360502536653	ATP1A1/DNAJC5/HSP90AA1/HSP90AB1/SLC2A1/PRDX1/CANX/PPIB/CTSD/CTSB	10
CC	GO:0005765	lysosomal membrane	20/365	378/19520	3.23083936098899e-05	0.000275471566568535	0.00015990119090398	LRP2/OCLN/ABCD1/SORT1/PSEN2/ZFYVE26/EEF1A1/ATP13A2/CLN3/SCARB2/DNAJC5/MTOR/HSP90AB1/LAMP2/CFTR/HLA-DQA1/CTSD/CP/HLA-DRB1/HLA-DQB1	20
CC	GO:0098852	lytic vacuole membrane	20/365	378/19520	3.23083936098899e-05	0.000275471566568535	0.00015990119090398	LRP2/OCLN/ABCD1/SORT1/PSEN2/ZFYVE26/EEF1A1/ATP13A2/CLN3/SCARB2/DNAJC5/MTOR/HSP90AB1/LAMP2/CFTR/HLA-DQA1/CTSD/CP/HLA-DRB1/HLA-DQB1	20
CC	GO:0031093	platelet alpha granule lumen	8/365	67/19520	3.45105286241404e-05	0.000289174429505729	0.000167855202745366	SERPINA1/SERPINA3/APP/IGF1/SERPINE1/CLU/VEGFA/FN1	8
CC	GO:0099522	region of cytosol	5/365	21/19520	3.53643355970689e-05	0.000291306222036873	0.000169092630508733	DAG1/HTT/MTOR/EIF4E/LRRK2	5
CC	GO:0031674	I band	11/365	134/19520	4.44221210399561e-05	0.000359819180423644	0.000208861902433478	SMN1/PSEN2/STUB1/HDAC4/ANK2/SLC2A1/ANK3/KRT8/RYR2/CASQ2/SCN5A	11
CC	GO:0097060	synaptic membrane	19/365	368/19520	7.03730738773524e-05	0.000560677277121201	0.000325452697137713	STXBP1/DAG1/ANK2/NLGN3/GRIN1/ANK3/IL1RAPL1/CDH2/CNR1/KCNA2/GABRG2/CHRM3/ADAM10/GRIN2B/GRIA1/GRIN2A/NRXN1/SLC6A4/ERBB4	19
CC	GO:0043202	lysosomal lumen	9/365	96/19520	7.84885334587508e-05	0.000615248826789562	0.000357129490100937	ATP13A2/SCARB2/HSP90AA1/MAN2B1/LAMP2/FASLG/CTSD/PDGFRB/CTSB	9
CC	GO:0005741	mitochondrial outer membrane	13/365	195/19520	8.1435755317615e-05	0.000628218683878744	0.000364658018799011	MAOA/RPS27A/BCL2/PINK1/MTOR/GJA1/BCL2L11/DMPK/LRRK2/PPP1R15A/BAX/ACSL4/CNR1	13
CC	GO:0032279	asymmetric synapse	17/365	318/19520	0.000110759618095753	0.000841080849914623	0.00048821673765891	ATP1A1/RTN4/MAPK1/SRC/CDKL5/NLGN3/GRIN1/NGFR/ITPR1/CDH2/ADAM10/GRIN2B/CAMK2A/GRIA1/NOS1/GRIN2A/ERBB4	17
CC	GO:0005911	cell-cell junction	22/365	485/19520	0.000129463797219744	0.000967990853058395	0.00056188336283225	OCLN/DAG1/ATP1A1/CTNNB1/GJA1/ANK2/SLC2A1/CCND1/NOTCH1/EPCAM/NGFR/ANK3/KIT/APP/KRT8/CDH2/KCNA2/VEGFA/ADAM10/GJC2/TRPV4/SCN5A	22
CC	GO:0045211	postsynaptic membrane	15/365	265/19520	0.000149671369004204	0.00110212553539459	0.00063974365060808	DAG1/ANK2/NLGN3/GRIN1/ANK3/IL1RAPL1/CDH2/GABRG2/CHRM3/ADAM10/GRIN2B/GRIA1/GRIN2A/SLC6A4/ERBB4	15
CC	GO:0016323	basolateral plasma membrane	13/365	211/19520	0.000179362403032189	0.00125380506617687	0.000727788082597791	ATP1A1/CTNNB1/ATP7A/HSP90AB1/ANK2/EGFR/SLC2A1/EPCAM/ANK3/KCNQ1/LEPR/CDH2/ERBB4	13
CC	GO:0005767	secondary lysosome	4/365	16/19520	0.00018316905287769	0.00125380506617687	0.000727788082597791	MAP1LC3A/CLN3/LAMP2/LRRK2	4
CC	GO:0016442	RISC complex	4/365	16/19520	0.00018316905287769	0.00125380506617687	0.000727788082597791	AGO1/AGO2/EIF4E/DICER1	4
CC	GO:0031332	RNAi effector complex	4/365	16/19520	0.00018316905287769	0.00125380506617687	0.000727788082597791	AGO1/AGO2/EIF4E/DICER1	4
CC	GO:0099524	postsynaptic cytosol	4/365	16/19520	0.00018316905287769	0.00125380506617687	0.000727788082597791	DAG1/HTT/MTOR/EIF4E	4
CC	GO:0098984	neuron to neuron synapse	17/365	342/19520	0.000262572478713722	0.00177236423131762	0.00102879275285493	ATP1A1/RTN4/MAPK1/SRC/CDKL5/NLGN3/GRIN1/NGFR/ITPR1/CDH2/ADAM10/GRIN2B/CAMK2A/GRIA1/NOS1/GRIN2A/ERBB4	17
CC	GO:0031968	organelle outer membrane	13/365	220/19520	0.000269889132905984	0.00179679614510011	0.0010429745871493	MAOA/RPS27A/BCL2/PINK1/MTOR/GJA1/BCL2L11/DMPK/LRRK2/PPP1R15A/BAX/ACSL4/CNR1	13
CC	GO:0031227	intrinsic component of endoplasmic reticulum membrane	11/365	165/19520	0.000284483753606586	0.00186836627368649	0.00108451843480178	HSD11B1/BSCL2/ATF6/CLN3/RTN4/CYP2E1/HLA-DQA1/B2M/CANX/HLA-DRB1/HLA-DQB1	11
CC	GO:0014069	postsynaptic density	16/365	313/19520	0.000290307354578729	0.00187438642673904	0.00108801291393993	ATP1A1/RTN4/MAPK1/SRC/CDKL5/GRIN1/NGFR/ITPR1/CDH2/ADAM10/GRIN2B/CAMK2A/GRIA1/NOS1/GRIN2A/ERBB4	16
CC	GO:0019867	outer membrane	13/365	222/19520	0.00029460429246039	0.00187438642673904	0.00108801291393993	MAOA/RPS27A/BCL2/PINK1/MTOR/GJA1/BCL2L11/DMPK/LRRK2/PPP1R15A/BAX/ACSL4/CNR1	13
CC	GO:0043034	costamere	4/365	18/19520	0.000298985241688164	0.00187438642673904	0.00108801291393993	DAG1/ANK2/ANK3/KRT8	4
CC	GO:0044291	cell-cell contact zone	7/365	69/19520	0.000300827451205031	0.00187438642673904	0.00108801291393993	ATP1A1/GJA1/ANK2/SLC2A1/ANK3/CDH2/SCN5A	7
CC	GO:0035578	azurophil granule lumen	8/365	91/19520	0.000304938022061456	0.00187594783192237	0.00108891925266449	DNAJC3/MAN2B1/DYNC1H1/MAPK1/SERPINA3/TTR/C3/MPO	8
CC	GO:0030016	myofibril	13/365	224/19520	0.000321226230783213	0.00195144935200802	0.00113274512960396	SMN1/DAG1/PSEN2/STUB1/HDAC4/ANK2/SLC2A1/ANK3/MMP2/KRT8/RYR2/CASQ2/SCN5A	13
CC	GO:0043292	contractile fiber	13/365	231/19520	0.000431166559358729	0.00258699935615238	0.00150165871225652	SMN1/DAG1/PSEN2/STUB1/HDAC4/ANK2/SLC2A1/ANK3/MMP2/KRT8/RYR2/CASQ2/SCN5A	13
CC	GO:0030017	sarcomere	12/365	203/19520	0.000458895262203739	0.00269118683270622	0.00156213574001574	SMN1/PSEN2/STUB1/HDAC4/ANK2/SLC2A1/ANK3/MMP2/KRT8/RYR2/CASQ2/SCN5A	12
CC	GO:0097038	perinuclear endoplasmic reticulum	4/365	20/19520	0.000459605981717318	0.00269118683270622	0.00156213574001574	CYBB/CLU/ADAM10/NOX4	4
CC	GO:0005776	autophagosome	8/365	98/19520	0.000504354600277601	0.00291805161589183	0.00169382246709771	GABARAP/MAP1LC3A/HTT/ATP13A2/CLN3/LAMP2/UBQLN2/LRRK2	8
CC	GO:0000791	euchromatin	5/365	36/19520	0.000520491417025145	0.00297598621969671	0.00172745139025064	KLF4/DNMT3A/CTNNB1/SP1/JUN	5
CC	GO:1904724	tertiary granule lumen	6/365	55/19520	0.000549263562830019	0.00310397780855104	0.00180174583645588	MMP9/CST3/B2M/HBB/CTSD/HP	6
CC	GO:0099572	postsynaptic specialization	16/365	333/19520	0.000572266402776074	0.00319679852585255	0.00185562487530536	ATP1A1/RTN4/MAPK1/SRC/CDKL5/GRIN1/NGFR/ITPR1/CDH2/ADAM10/GRIN2B/CAMK2A/GRIA1/NOS1/GRIN2A/ERBB4	16
CC	GO:0045334	clathrin-coated endocytic vesicle	6/365	57/19520	0.000666369933262147	0.00367878809379767	0.00213540222901836	CTLA4/APOE/HLA-DQA1/SFTPB/HLA-DRB1/HLA-DQB1	6
CC	GO:0034399	nuclear periphery	9/365	128/19520	0.000684878236957008	0.00367878809379767	0.00213540222901836	MATR3/DNMT3A/DAG1/SMC1A/CEBPB/ATF4/RAD21/SATB2/KRT8	9
CC	GO:0005766	primary lysosome	10/365	155/19520	0.000688826577233721	0.00367878809379767	0.00213540222901836	DNAJC3/DNAJC5/MAN2B1/DYNC1H1/MAPK1/LAMP2/SERPINA3/TTR/C3/MPO	10
CC	GO:0042582	azurophil granule	10/365	155/19520	0.000688826577233721	0.00367878809379767	0.00213540222901836	DNAJC3/DNAJC5/MAN2B1/DYNC1H1/MAPK1/LAMP2/SERPINA3/TTR/C3/MPO	10
CC	GO:0005641	nuclear envelope lumen	3/365	10/19520	0.00070573036076112	0.00368801027236456	0.00214075536710787	SORL1/BCHE/APP	3
CC	GO:0017146	NMDA selective glutamate receptor complex	3/365	10/19520	0.00070573036076112	0.00368801027236456	0.00214075536710787	GRIN1/GRIN2B/GRIN2A	3
CC	GO:0030176	integral component of endoplasmic reticulum membrane	10/365	157/19520	0.000760742863640525	0.00393320246520527	0.00228308048662554	HSD11B1/BSCL2/ATF6/CLN3/RTN4/HLA-DQA1/B2M/CANX/HLA-DRB1/HLA-DQB1	10
CC	GO:0046930	pore complex	4/365	23/19520	0.000803629678525261	0.00411120025013976	0.00238640170465119	BCL2/SPG7/BAX/ADAM10	4
CC	GO:0005802	trans-Golgi network	13/365	251/19520	0.000935448075686901	0.00473570588316494	0.00274890443293958	ATP7A/TRAPPC9/CLN3/SORL1/FURIN/LRRK2/HLA-DQA1/APP/HLA-DRB1/SLC2A4/ADAM10/MME/HLA-DQB1	13
CC	GO:0031838	haptoglobin-hemoglobin complex	3/365	11/19520	0.000956966245789806	0.00479469686034893	0.00278314654228614	HBA1/HBB/HP	3
CC	GO:0034703	cation channel complex	12/365	222/19520	0.00100886989217271	0.00500317109791771	0.0029041582288108	GRIN1/KCNQ1/RYR2/CASQ2/KCNA2/GRIN2B/GRIA1/KCNH2/SCN5A/NOS1/GRIN2A/KCNQ2	12
CC	GO:0016328	lateral plasma membrane	6/365	62/19520	0.00104403857283157	0.00507402746396144	0.00294528776335644	OCLN/ATP1A1/CTNNB1/EPCAM/ANK3/SCN5A	6
CC	GO:0044304	main axon	6/365	62/19520	0.00104403857283157	0.00507402746396144	0.00294528776335644	DAG1/ANK3/APP/KCNA2/GJC2/KCNQ2	6
CC	GO:0045335	phagocytic vesicle	9/365	136/19520	0.00105595711247491	0.00508114016497828	0.00294941642671471	CYBB/STXBP1/ATP7A/MTOR/LAMP2/B2M/ABCA1/TLR2/MPO	9
CC	GO:0043209	myelin sheath	5/365	42/19520	0.00107165437101189	0.00510611788540959	0.00296391508184919	PLP1/BCL2/HSP90AA1/MPZ/GJC2	5
CC	GO:0042611	MHC protein complex	4/365	25/19520	0.00111470994643287	0.00525969935889682	0.00305306352216666	HLA-DQA1/B2M/HLA-DRB1/HLA-DQB1	4
CC	GO:0120111	neuron projection cytoplasm	7/365	86/19520	0.00114322674237067	0.00534238650761678	0.00310106039428481	PURA/DYNC1H1/HSPB1/MAPK1/CDKL5/SPAST/LRRK2	7
CC	GO:1902495	transmembrane transporter complex	15/365	323/19520	0.00118642798806261	0.00549146668760407	0.0031875959980028	ATP1A1/CFTR/GRIN1/KCNQ1/RYR2/CASQ2/KCNA2/GABRG2/GRIN2B/GRIA1/KCNH2/SCN5A/NOS1/GRIN2A/KCNQ2	15
CC	GO:0042583	chromaffin granule	3/365	12/19520	0.00125833455099986	0.00571542609145729	0.00331759625841576	DNAJC5/CLU/DBH	3
CC	GO:1990909	Wnt signalosome	3/365	12/19520	0.00125833455099986	0.00571542609145729	0.00331759625841576	CTNNB1/GSK3B/LRRK2	3
CC	GO:0031965	nuclear membrane	14/365	295/19520	0.00139731864589443	0.00628793390652492	0.00364991615106926	MATR3/EDNRB/SORT1/BCL2/PSEN2/PHF8/P2RX7/SPAST/EGFR/CCND1/DMPK/ITPR1/NR4A1/NRXN1	14
CC	GO:0033391	chromatoid body	3/365	13/19520	0.00161326571184987	0.00712770123599123	0.00413737043804559	ARNTL/CLOCK/EIF4E	3
CC	GO:0044292	dendrite terminus	3/365	13/19520	0.00161326571184987	0.00712770123599123	0.00413737043804559	HSP90AA1/HSP90AB1/CDKL5	3
CC	GO:0034702	ion channel complex	14/365	301/19520	0.00168679541341903	0.00738542856686171	0.00428697174771267	CFTR/GRIN1/KCNQ1/RYR2/CASQ2/KCNA2/GABRG2/GRIN2B/GRIA1/KCNH2/SCN5A/NOS1/GRIN2A/KCNQ2	14
CC	GO:1990351	transporter complex	15/365	338/19520	0.00185152803090733	0.00803430913411576	0.00466362323574404	ATP1A1/CFTR/GRIN1/KCNQ1/RYR2/CASQ2/KCNA2/GABRG2/GRIN2B/GRIA1/KCNH2/SCN5A/NOS1/GRIN2A/KCNQ2	15
CC	GO:0030134	COPII-coated ER to Golgi transport vesicle	7/365	94/19520	0.00191847836905139	0.00825115475538918	0.0047894942049909	SERPINA1/HLA-DQA1/B2M/APP/HLA-DRB1/GRIA1/HLA-DQB1	7
CC	GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane	4/365	29/19520	0.00197337821570795	0.00833966793768751	0.00484087287697694	HLA-DQA1/CANX/HLA-DRB1/HLA-DQB1	4
CC	GO:0098553	lumenal side of endoplasmic reticulum membrane	4/365	29/19520	0.00197337821570795	0.00833966793768751	0.00484087287697694	HLA-DQA1/CANX/HLA-DRB1/HLA-DQB1	4
CC	GO:0033268	node of Ranvier	3/365	14/19520	0.0020249456307981	0.00848382393592996	0.00492455017290282	DAG1/ANK3/KCNQ2	3
CC	GO:0005790	smooth endoplasmic reticulum	4/365	30/19520	0.00224379324815241	0.00932037195386388	0.00541013576702517	GABARAP/DNAJC3/APP/RYR2	4
CC	GO:0070382	exocytic vesicle	11/365	215/19520	0.00248875431855391	0.0102502932103153	0.00594992111839829	CLN3/DNAJC5/NGF/LRRK2/GRIN1/APP/IGF1/ADAM10/MME/GRIA1/GRIN2A	11
CC	GO:0032839	dendrite cytoplasm	4/365	31/19520	0.00253868915805665	0.0102816910901294	0.00596814644174722	PURA/MAPK1/CDKL5/LRRK2	4
CC	GO:1902555	endoribonuclease complex	4/365	31/19520	0.00253868915805665	0.0102816910901294	0.00596814644174722	AGO1/AGO2/DICER1/TSEN54	4
CC	GO:0030315	T-tubule	5/365	51/19520	0.00258059041938129	0.0103650160646224	0.00601651354844876	ATP1A1/ANK2/ANK3/SLC2A4/SCN5A	5
CC	GO:0030140	trans-Golgi network transport vesicle	4/365	32/19520	0.00285913336083788	0.0113896624046492	0.0066112833537925	SORT1/ATP7A/FURIN/SLC2A4	4
CC	GO:0042613	MHC class II protein complex	3/365	16/19520	0.00303013070992899	0.0119727115855731	0.0069497221246125	HLA-DQA1/HLA-DRB1/HLA-DQB1	3
CC	GO:0055037	recycling endosome	10/365	190/19520	0.00314913779720563	0.0123425884632414	0.00716442215323522	CLN3/SORL1/ANK2/SLC9A6/CFTR/TF/B2M/APP/NTRK1/GRIA1	10
CC	GO:0031901	early endosome membrane	9/365	162/19520	0.00349806781878209	0.0136004876794248	0.00789458674049347	CLN3/SORL1/SLC9A6/CFTR/EGFR/B2M/NTRK1/GRIA1/CAV1	9
CC	GO:0070820	tertiary granule	9/365	164/19520	0.00379304269368971	0.0146303075328032	0.00849235958152752	MMP9/CYBB/LAMP2/CST3/B2M/HBB/CTSD/ADAM10/HP	9
CC	GO:0008021	synaptic vesicle	10/365	197/19520	0.00407032643596901	0.0155762098258342	0.00904142134139821	CLN3/DNAJC5/NGF/LRRK2/GRIN1/APP/ADAM10/MME/GRIA1/GRIN2A	10
CC	GO:0042734	presynaptic membrane	8/365	137/19520	0.00428469052796886	0.0161408098635063	0.0093691510578724	STXBP1/CDH2/CNR1/KCNA2/GRIN2A/NRXN1/SLC6A4/ERBB4	8
CC	GO:0031143	pseudopodium	3/365	18/19520	0.00429484811418522	0.0161408098635063	0.0093691510578724	MAPK1/MAPK3/PLA2G6	3
CC	GO:0016363	nuclear matrix	7/365	109/19520	0.00440664758844198	0.0161408098635063	0.0093691510578724	MATR3/DNMT3A/SMC1A/CEBPB/RAD21/SATB2/KRT8	7
CC	GO:0034358	plasma lipoprotein particle	4/365	36/19520	0.00441713520956036	0.0161408098635063	0.0093691510578724	CETP/APOE/LPL/CLU	4
CC	GO:0098576	lumenal side of membrane	4/365	36/19520	0.00441713520956036	0.0161408098635063	0.0093691510578724	HLA-DQA1/CANX/HLA-DRB1/HLA-DQB1	4
CC	GO:1990777	lipoprotein particle	4/365	36/19520	0.00441713520956036	0.0161408098635063	0.0093691510578724	CETP/APOE/LPL/CLU	4
CC	GO:0090575	RNA polymerase II transcription regulator complex	9/365	170/19520	0.00479617627087158	0.0173950870719671	0.0100972132018349	CTNNB1/CLOCK/CEBPB/ATF4/GATA4/PPARG/DDIT3/FOS/JUN	9
CC	GO:0030658	transport vesicle membrane	10/365	206/19520	0.0055540398659732	0.0199945435175035	0.0116061027998504	DNAJC5/SORL1/LRRK2/HLA-DQA1/B2M/ITPR1/HLA-DRB1/GRIA1/HLA-DQB1/DBH	10
CC	GO:0055038	recycling endosome membrane	6/365	87/19520	0.00581565365430697	0.0207824093823028	0.0120634301807606	SORL1/SLC9A6/CFTR/B2M/NTRK1/GRIA1	6
CC	GO:0030669	clathrin-coated endocytic vesicle membrane	4/365	39/19520	0.00590343299449328	0.0207903509806068	0.0120680399887429	APOE/HLA-DQA1/HLA-DRB1/HLA-DQB1	4
CC	GO:0032994	protein-lipid complex	4/365	39/19520	0.00590343299449328	0.0207903509806068	0.0120680399887429	CETP/APOE/LPL/CLU	4
CC	GO:0012507	ER to Golgi transport vesicle membrane	5/365	62/19520	0.00601817882274558	0.0210419777543479	0.0122141001476396	HLA-DQA1/B2M/HLA-DRB1/GRIA1/HLA-DQB1	5
CC	GO:0000421	autophagosome membrane	4/365	40/19520	0.00646441162203078	0.0224407432021926	0.0130260324413853	GABARAP/MAP1LC3A/ATP13A2/LAMP2	4
CC	GO:0016327	apicolateral plasma membrane	3/365	21/19520	0.00671628556350894	0.0231497502401797	0.0134375851513281	OCLN/KRT8/CDH2	3
CC	GO:0098982	GABA-ergic synapse	5/365	64/19520	0.0068801408528156	0.0235475243272421	0.0136684784918798	DAG1/NLGN3/CNR1/GABRG2/ERBB4	5
CC	GO:0033017	sarcoplasmic reticulum membrane	4/365	41/19520	0.00705963612837906	0.023992889219526	0.0139269965580095	DMPK/RYR2/CASQ2/NOS1	4
CC	GO:0098802	plasma membrane signaling receptor complex	13/365	318/19520	0.00714973657769815	0.0241303609497312	0.0140067938802858	PLP1/CD4/IGF1R/TF/B2M/IL6/GRIN1/TLR2/GRIN2B/GRIA1/CALCR/GRIN2A/BMP2	13
CC	GO:0031594	neuromuscular junction	5/365	69/19520	0.00940551076463965	0.0315246774594129	0.018298924754435	PSEN2/DNAJC5/HDAC4/ANK3/APP	5
CC	GO:0099699	integral component of synaptic membrane	7/365	128/19520	0.0103719616019026	0.0345258447844154	0.0200409928573171	NLGN3/CDH2/CNR1/GRIA1/GRIN2A/SLC6A4/ERBB4	7
CC	GO:0005905	clathrin-coated pit	5/365	71/19520	0.0105735447481479	0.0347358036640033	0.0201628663243511	LRP2/SORT1/TF/APP/SLC2A4	5
CC	GO:0060076	excitatory synapse	4/365	46/19520	0.0105779813627006	0.0347358036640033	0.0201628663243511	NLGN3/FGFR2/GRIN1/GRIA1	4
CC	GO:0031252	cell leading edge	15/365	411/19520	0.0109228145473737	0.0356274353692861	0.0206804259886694	OCLN/DAG1/EEF1A1/ATP7A/ATF4/SRC/CDKL5/CXCR4/KITLG/APP/CDH2/KCNA2/GABRG2/GRIA1/TRPV4	15
CC	GO:0099055	integral component of postsynaptic membrane	6/365	100/19520	0.0112343341825081	0.0363992427513261	0.0211284320064011	NLGN3/CDH2/GRIA1/GRIN2A/SLC6A4/ERBB4	6
CC	GO:0005938	cell cortex	12/365	301/19520	0.0114977690134381	0.0370060645068271	0.0214806698891697	PSEN2/CTNNB1/EEF1A1/DYNC1H1/SNCA/SLC2A1/FGFR2/ASTN2/CDH2/NOS2/CAV1/TRPV4	12
CC	GO:0008328	ionotropic glutamate receptor complex	4/365	48/19520	0.0122523631809911	0.0390899175252488	0.0226902705149809	GRIN1/GRIN2B/GRIA1/GRIN2A	4
CC	GO:0005796	Golgi lumen	6/365	102/19520	0.0123060851468376	0.0390899175252488	0.0226902705149809	DAG1/NGF/FURIN/BGLAP/APP/PROC	6
CC	GO:0017053	transcription repressor complex	5/365	74/19520	0.012505739738199	0.0394661656673033	0.022908668830057	GLI3/SP1/HDAC4/HMGB1/CCND1	5
CC	GO:0030667	secretory granule membrane	12/365	305/19520	0.0126554594575514	0.0396809890088386	0.0230333659397201	CYBB/PTPRC/DNAJC5/SNCA/CD14/LAMP2/ITPR1/TLR2/ADAM10/MME/CAV1/DBH	12
CC	GO:0005819	spindle	14/365	381/19520	0.0129507646761245	0.040148957520541	0.0233050045819905	IKBKG/CTNNB1/SMC1A/XIAP/HSPB1/RAD21/MAPK1/WDR62/ATM/ALMS1/SPAST/APP/BIRC5/AURKA	14
CC	GO:0036464	cytoplasmic ribonucleoprotein granule	10/365	234/19520	0.0129699307216563	0.040148957520541	0.0233050045819905	SMN1/ARNTL/AGO1/RPS6/AGO2/CLOCK/TARDBP/EIF4E/SOCS1/GHR	10
CC	GO:0005791	rough endoplasmic reticulum	5/365	75/19520	0.0131995070191259	0.0406010152613619	0.0235674076024366	CYBB/GNRH1/EDN1/BGLAP/APP	5
CC	GO:0098687	chromosomal region	13/365	345/19520	0.0134876443629186	0.0412263846564681	0.0239304117130895	DNMT3A/PARP1/PSEN2/PURA/SMC1A/CEBPB/PRKDC/SETX/RAD21/ATM/BRCA2/TERT/BIRC5	13
CC	GO:0034364	high-density lipoprotein particle	3/365	27/19520	0.0136019506035135	0.0413159249581723	0.0239823865904054	CETP/APOE/CLU	3
CC	GO:0098936	intrinsic component of postsynaptic membrane	6/365	105/19520	0.014045484451137	0.042262352308948	0.0245317531271347	NLGN3/CDH2/GRIA1/GRIN2A/SLC6A4/ERBB4	6
CC	GO:0098878	neurotransmitter receptor complex	4/365	50/19520	0.0140874507696493	0.042262352308948	0.0245317531271347	GRIN1/GRIN2B/GRIA1/GRIN2A	4
CC	GO:0030670	phagocytic vesicle membrane	5/365	77/19520	0.0146639798956948	0.0437220504865502	0.0253790546467305	CYBB/ATP7A/LAMP2/B2M/TLR2	5
CC	GO:0044295	axonal growth cone	3/365	28/19520	0.0150270212269246	0.0445312946114961	0.0258487913274441	L1CAM/HSP90AA1/HSP90AB1	3
CC	GO:0031902	late endosome membrane	7/365	140/19520	0.0163363745714264	0.0475514845239618	0.0276019013481087	ATP13A2/CLN3/SCARB2/SORL1/LAMP2/HLA-DRB1/NTRK1	7
CC	GO:0099240	intrinsic component of synaptic membrane	7/365	140/19520	0.0163363745714264	0.0475514845239618	0.0276019013481087	NLGN3/CDH2/CNR1/GRIA1/GRIN2A/SLC6A4/ERBB4	7
CC	GO:0031256	leading edge membrane	8/365	173/19520	0.0163397076450651	0.0475514845239618	0.0276019013481087	EEF1A1/ATF4/SRC/CDKL5/KCNA2/GABRG2/GRIA1/TRPV4	8
CC	GO:0005942	phosphatidylinositol 3-kinase complex	3/365	29/19520	0.0165332108051419	0.0478282169720176	0.0277625344346994	PIK3R2/PIK3CG/SOCS1	3
CC	GO:0032993	protein-DNA complex	9/365	208/19520	0.0166713261856373	0.0479423936462706	0.0278288098271616	NUPR1/PARP1/CTNNB1/EP300/PRKDC/SP1/DDIT3/FOS/TERT	9
CC	GO:0035770	ribonucleoprotein granule	10/365	244/19520	0.0169110439733359	0.0481888514879601	0.0279718696096454	SMN1/ARNTL/AGO1/RPS6/AGO2/CLOCK/TARDBP/EIF4E/SOCS1/GHR	10
CC	GO:0005845	mRNA cap binding complex	2/365	11/19520	0.0171536446654673	0.0481888514879601	0.0279718696096454	AGO2/EIF4E	2
CC	GO:0035253	ciliary rootlet	2/365	11/19520	0.0171536446654673	0.0481888514879601	0.0279718696096454	PSEN2/APP	2
CC	GO:0099523	presynaptic cytosol	2/365	11/19520	0.0171536446654673	0.0481888514879601	0.0279718696096454	HTT/LRRK2	2
MF	GO:0030546	signaling receptor activator activity	41/365	492/18337	8.24630943810083e-15	6.68775695429978e-12	4.36620383933128e-12	SPP1/NPPA/CCL5/GNRH1/EDN1/MIF/MANF/IL18/NGF/HMGB1/LEP/NRG1/IL1RN/IL6/KITLG/CXCL12/FASLG/BMP4/CCL2/THBS4/GHRL/CSF3/APP/PRL/IFNG/IGF1/AGT/TNFSF11/GDNF/TTR/ADIPOQ/POMC/VEGFA/GDF15/FBN1/IL24/CD40LG/BMP2/SHH/IL10/NPY	41
MF	GO:0048018	receptor ligand activity	40/365	486/18337	2.71014088108005e-14	8.04664603226128e-12	5.25337524073908e-12	SPP1/NPPA/CCL5/GNRH1/EDN1/MIF/MANF/IL18/NGF/HMGB1/LEP/NRG1/IL1RN/IL6/KITLG/CXCL12/FASLG/BMP4/CCL2/THBS4/GHRL/CSF3/PRL/IFNG/IGF1/AGT/TNFSF11/GDNF/TTR/ADIPOQ/POMC/VEGFA/GDF15/FBN1/IL24/CD40LG/BMP2/SHH/IL10/NPY	40
MF	GO:0044389	ubiquitin-like protein ligase binding	32/365	312/18337	2.97656450021996e-14	8.04664603226128e-12	5.25337524073908e-12	CBS/GABARAP/RPS27A/BCL2/MAP1LC3A/NFKBIA/IKBKG/PINK1/STUB1/CEBPB/RPL5/HSP90AA1/HSP90AB1/GSK3B/RTN4/UBE2J1/SRC/BRCA1/EGFR/CXCR4/CDKN1A/JUN/STAT1/HSPA1B/NGFR/TXNIP/HSPA1A/CLU/AURKA/KCNH2/SCN5A/UCHL1	32
MF	GO:0140297	DNA-binding transcription factor binding	34/365	376/18337	1.81181661932585e-13	3.16324806789103e-11	2.06517460983736e-11	KLF4/BCL2/NFKBIA/MEF2C/ARNTL/HCFC1/PARP1/CTNNB1/NSD1/EP300/CEBPB/GTF2I/MED12/ATF4/GSK3B/CREBBP/SP1/HDAC4/HSPB1/EIF4E/GATA4/PPARA/PPARG/SRC/DDIT3/HMGB1/FOS/AR/JUN/STAT1/MYC/NR4A1/FOXP2/CDKN2A	34
MF	GO:0031625	ubiquitin protein ligase binding	30/365	293/18337	2.05334365289877e-13	3.16324806789103e-11	2.06517460983736e-11	CBS/GABARAP/RPS27A/BCL2/MAP1LC3A/NFKBIA/IKBKG/PINK1/STUB1/RPL5/HSP90AA1/HSP90AB1/GSK3B/RTN4/UBE2J1/SRC/BRCA1/EGFR/CXCR4/CDKN1A/JUN/HSPA1B/NGFR/TXNIP/HSPA1A/CLU/AURKA/KCNH2/SCN5A/UCHL1	30
MF	GO:0042277	peptide binding	31/365	315/18337	2.34025751015366e-13	3.16324806789103e-11	2.06517460983736e-11	EDNRB/IGF1R/NFKBIA/ITM2B/HSP90AB1/SORL1/BCHE/CD14/PPARG/AGER/ADRB2/FURIN/CST3/APOE/HLA-DQA1/PPIB/GRIN1/NGFR/TLR2/GSTM1/LEPR/HLA-DRB1/CLU/GHR/CRHR1/GRIN2B/MME/GRIA1/HLA-DQB1/CALCR/GRIN2A	31
MF	GO:0033218	amide binding	34/365	391/18337	5.56206763559824e-13	6.44405264638596e-11	4.20709777549761e-11	EDNRB/IGF1R/NFKBIA/ITM2B/HSP90AB1/SORL1/BCHE/CD14/PPARG/AGER/ADRB2/FURIN/CST3/APOE/HLA-DQA1/FKBP5/PPIB/GRIN1/NGFR/TLR2/GSTM1/LEPR/HLA-DRB1/RYR2/CLU/PLA2G4A/GHR/CRHR1/GRIN2B/MME/GRIA1/HLA-DQB1/CALCR/GRIN2A	34
MF	GO:0005125	cytokine activity	24/365	235/18337	5.95051867111472e-11	6.03233830284255e-09	3.9383038046983e-09	SPP1/CCL5/EDN1/MIF/IL18/HMGB1/NRG1/IL1RN/IL6/KITLG/CXCL12/FASLG/BMP4/CCL2/CSF3/IFNG/TNFSF11/ADIPOQ/VEGFA/GDF15/IL24/CD40LG/BMP2/IL10	24
MF	GO:0001540	amyloid-beta binding	15/365	84/18337	9.76850216118551e-11	8.80250583635717e-09	5.74684980944598e-09	ITM2B/SORL1/BCHE/AGER/ADRB2/CST3/APOE/GRIN1/NGFR/TLR2/CLU/GRIN2B/GRIA1/CALCR/GRIN2A	15
MF	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	24/365	271/18337	1.12027001035435e-09	8.54574829300871e-08	5.57922174233679e-08	KLF4/NFKBIA/ARNTL/PARP1/CTNNB1/NSD1/EP300/CEBPB/GTF2I/MED12/GSK3B/CREBBP/SP1/HSPB1/GATA4/PPARA/PPARG/SRC/FOS/JUN/STAT1/NR4A1/FOXP2/CDKN2A	24
MF	GO:0046906	tetrapyrrole binding	18/365	150/18337	1.1591027277817e-09	8.54574829300871e-08	5.57922174233679e-08	HBA1/CYP3A5/CBS/CYBB/PTGS1/MTR/CYP2D6/CYP2U1/CYP2E1/SRC/HBB/CYP19A1/CYP1A1/CYP17A1/NOX4/NOS2/NOS1/MPO	18
MF	GO:0020037	heme binding	17/365	140/18337	2.80825321027967e-09	1.89791112794735e-07	1.23908014453568e-07	HBA1/CYP3A5/CBS/CYBB/PTGS1/CYP2D6/CYP2U1/CYP2E1/SRC/HBB/CYP19A1/CYP1A1/CYP17A1/NOX4/NOS2/NOS1/MPO	17
MF	GO:0019825	oxygen binding	10/365	39/18337	3.28510445084061e-09	2.0493997766398e-07	1.33798181277152e-07	HBA1/CYP3A5/CBS/CYP2E1/HBB/CYP19A1/SOD2/CYP1A1/CYP17A1/NOX4	10
MF	GO:0005178	integrin binding	16/365	142/18337	2.44008714774706e-08	1.41350762630205e-06	9.22829951365994e-07	SPP1/ICAM1/SRC/EGFR/HMGB1/VCAM1/PRKCA/NRG1/KDR/CXCL12/THBS4/IGF1/ADAM10/FBN1/FN1/CD40LG	16
MF	GO:0033613	activating transcription factor binding	12/365	78/18337	4.30892073773692e-08	2.3296898122031e-06	1.52097342532047e-06	MEF2C/HCFC1/CTNNB1/EP300/GTF2I/CREBBP/HDAC4/GATA4/PPARG/FOS/JUN/MYC	12
MF	GO:0019838	growth factor binding	15/365	137/18337	9.85076693683784e-08	4.99310749110968e-06	3.25982616396673e-06	LRP2/COL2A1/SORT1/IGF1R/IL1R1/EGFR/FURIN/KDR/IL1RN/FGFR2/NGFR/PDGFRB/GHR/NTRK1/SCN5A	15
MF	GO:0051087	chaperone binding	13/365	101/18337	1.04676065207916e-07	4.99366405197766e-06	3.26018952319393e-06	LRP2/ATP1A1/STUB1/DNAJC3/ATP7A/CFTR/DNAJC10/CP/BAX/TERT/BIRC5/CLU/FN1	13
MF	GO:0008083	growth factor activity	16/365	162/18337	1.5668229393468e-07	6.92635385880205e-06	4.52197545717104e-06	MANF/NGF/NRG1/IL6/KITLG/CXCL12/BMP4/THBS4/CSF3/IGF1/AGT/GDNF/VEGFA/GDF15/BMP2/IL10	16
MF	GO:0031072	heat shock protein binding	14/365	123/18337	1.62269695828901e-07	6.92635385880205e-06	4.52197545717104e-06	ARNTL/STUB1/HTT/HSP90AB1/SNCA/CYP2E1/AHR/KDR/FKBP5/DNAJC10/HSPA1B/HSPA1A/BAX/CYP1A1	14
MF	GO:0042826	histone deacetylase binding	13/365	113/18337	3.9721880954082e-07	1.61072227268802e-05	1.05158453262649e-05	KLF4/MEF2C/PARP1/CEBPB/GLI3/HSP90AA1/HSP90AB1/SP1/HDAC4/CCND1/HSPA1B/HSPA1A/SATB2	13
MF	GO:0001085	RNA polymerase II transcription factor binding	9/365	52/18337	7.68623940464964e-07	2.96835245579565e-05	1.93793404538284e-05	KLF4/CTNNB1/EP300/ATF4/GSK3B/CREBBP/HDAC4/GATA4/AR	9
MF	GO:0042562	hormone binding	11/365	84/18337	8.4735322789364e-07	3.00972936028507e-05	1.96494758676539e-05	LRP2/EDNRB/IGF1R/ATP1A1/EGFR/AR/LEPR/TTR/GHR/CRHR1/CALCR	11
MF	GO:0061134	peptidase regulator activity	18/365	230/18337	8.75230824028319e-07	3.00972936028507e-05	1.96494758676539e-05	PINK1/RPS6KA3/XIAP/SNCA/NGF/SERPINA1/FURIN/CST3/SERPINA3/C4A/APP/BIRC5/SERPINI1/SERPINE1/AGT/CAV1/FN1/C3	18
MF	GO:0004857	enzyme inhibitor activity	24/365	385/18337	8.90672067162044e-07	3.00972936028507e-05	1.96494758676539e-05	RPS6KA3/DNAJC3/RPL5/XIAP/HSPB1/SNCA/NGF/SERPINA1/FURIN/CST3/LRRK2/CDKN1A/NOTCH1/SERPINA3/C4A/TXNIP/APP/BIRC5/SERPINI1/SERPINE1/AGT/SOCS1/C3/CDKN2A	24
MF	GO:0005179	hormone activity	13/365	122/18337	9.67304749314286e-07	3.13793660677554e-05	2.0486496374951e-05	NPPA/GNRH1/EDN1/LEP/GHRL/PRL/IGF1/AGT/TTR/ADIPOQ/POMC/FBN1/NPY	13
MF	GO:0044325	ion channel binding	13/365	128/18337	1.67479928993396e-06	5.22408547744786e-05	3.41062365520965e-05	NEDD4L/CTNNB1/HTT/HSP90AB1/ANK2/SRC/LRRK2/ANK3/KCNQ1/RYR2/CAV1/SCN5A/NOS1	13
MF	GO:0005506	iron ion binding	14/365	150/18337	1.85525213502274e-06	5.57262770927201e-05	3.63817475211087e-05	HBA1/CYP3A5/PHF8/CYP2D6/CYP2U1/SNCA/CYP2E1/P4HTM/TF/TET1/CYP19A1/CYP1A1/CYP17A1/XDH	14
MF	GO:0097110	scaffold protein binding	9/365	58/18337	2.00273573606591e-06	5.80078100696233e-05	3.78712810241035e-05	HSP90AA1/MAPK3/SRC/NLGN3/KCNQ1/KRT8/KCNH2/SCN5A/NOS1	9
MF	GO:0005126	cytokine receptor binding	19/365	270/18337	2.15403954755761e-06	5.84903959383307e-05	3.81863445479659e-05	CCL5/MIF/IL18/NGF/IL1RN/IL6/KITLG/CXCL12/FASLG/STAT1/CCL2/CSF3/PRL/IFNG/TNFSF11/VEGFA/NTRK1/CD40LG/IL10	19
MF	GO:0048156	tau protein binding	8/365	44/18337	2.16363980043147e-06	5.84903959383307e-05	3.81863445479659e-05	STUB1/EP300/HSP90AA1/HSP90AB1/GSK3B/SNCA/APOE/CLU	8
MF	GO:0046982	protein heterodimerization activity	21/365	324/18337	2.34937264231451e-06	6.14626197715183e-05	4.01268060809575e-05	XBP1/PIK3R2/CYBB/BCL2/IKBKG/MEF2C/ATP1A1/ATF6/SMC1A/CEBPB/ATF4/VAPB/GADD45A/AGTR1/DDIT3/ATF3/AHR/BAX/AURKA/NR4A1/CAV1	21
MF	GO:0004866	endopeptidase inhibitor activity	15/365	180/18337	3.31660709035445e-06	8.40552609461705e-05	5.48767554752726e-05	RPS6KA3/XIAP/SNCA/NGF/SERPINA1/FURIN/CST3/SERPINA3/C4A/APP/BIRC5/SERPINI1/SERPINE1/AGT/C3	15
MF	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	14/365	160/18337	3.98511152416274e-06	9.79371347301812e-05	6.39397478996446e-05	CYP3A5/PTGS1/PHF8/CYP2D6/CYP2U1/CYP2E1/P4HTM/TET1/CYP19A1/CYP1A1/CYP17A1/NOS2/NOS1/DBH	14
MF	GO:0005496	steroid binding	11/365	100/18337	4.86487798477031e-06	0.000116041648401433	7.575955499503e-05	HSD11B1/ATP1A1/SCARB2/RORA/HSD11B2/CETP/GRAMD1B/ABCA1/AR/CAV1/ESR2	11
MF	GO:0030414	peptidase inhibitor activity	15/365	187/18337	5.30436672399181e-06	0.000122909754661639	8.02435026215904e-05	RPS6KA3/XIAP/SNCA/NGF/SERPINA1/FURIN/CST3/SERPINA3/C4A/APP/BIRC5/SERPINI1/SERPINE1/AGT/C3	15
MF	GO:0008013	beta-catenin binding	10/365	85/18337	7.17490559497897e-06	0.000160341329201749	0.000104681275343604	KLF4/CTNNB1/EP300/GLI3/MED12/GSK3B/RORA/GJA1/AR/CDH2	10
MF	GO:0061135	endopeptidase regulator activity	15/365	192/18337	7.31520244200334e-06	0.000160341329201749	0.000104681275343604	RPS6KA3/XIAP/SNCA/NGF/SERPINA1/FURIN/CST3/SERPINA3/C4A/APP/BIRC5/SERPINI1/SERPINE1/AGT/C3	15
MF	GO:0016209	antioxidant activity	10/365	86/18337	7.97724298600231e-06	0.000170251159517049	0.000111151058780032	HBA1/PTGS1/TXN/APOE/PRDX1/HBB/SOD2/HP/NQO1/MPO	10
MF	GO:0008395	steroid hydroxylase activity	7/365	38/18337	8.66851643301603e-06	0.000180260687876308	0.000117685931600731	CYP3A5/CYP2D6/CYP2U1/CYP2E1/CYP19A1/CYP1A1/CYP17A1	7
MF	GO:0051427	hormone receptor binding	14/365	173/18337	9.86049740040369e-06	0.000199921584793185	0.000130521847168502	NPPA/GNRH1/PARP1/CTNNB1/NSD1/EP300/CEBPB/MED12/PPARG/SRC/LEP/STAT1/NR4A1/FOXP2	14
MF	GO:0070491	repressing transcription factor binding	9/365	71/18337	1.11572054528815e-05	0.000220694966397241	0.000144084065283681	BCL2/SP1/HDAC4/EIF4E/PPARA/PPARG/HMGB1/STAT1/MYC	9
MF	GO:0035035	histone acetyltransferase binding	6/365	27/18337	1.2405289883712e-05	0.000239540240373583	0.000156387489010204	CEBPB/GLI3/SP1/ETS1/STAT1/EGR1	6
MF	GO:1990841	promoter-specific chromatin binding	8/365	58/18337	1.83601288007828e-05	0.000346280568777555	0.000226074535784425	KLF4/MECP2/HDAC4/GADD45A/DNMT1/CHD7/STAT1/EGR1	8
MF	GO:0051787	misfolded protein binding	6/365	29/18337	1.92490945559298e-05	0.000352486110090674	0.000230125917808565	STUB1/DNAJC3/DNAJC10/HSPA1B/HSPA1A/CLU	6
MF	GO:0001618	virus receptor activity	9/365	76/18337	1.95584154797538e-05	0.000352486110090674	0.000230125917808565	CCR5/CD4/DAG1/SCARB2/ICAM1/EGFR/CXCR4/HSPA1B/HSPA1A	9
MF	GO:0035258	steroid hormone receptor binding	9/365	77/18337	2.17637207267669e-05	0.000367716198112666	0.000240069112402714	PARP1/CTNNB1/NSD1/EP300/CEBPB/PPARG/SRC/NR4A1/FOXP2	9
MF	GO:0046332	SMAD binding	9/365	77/18337	2.17637207267669e-05	0.000367716198112666	0.000240069112402714	PARP1/PURA/CTNNB1/STUB1/USP9X/GATA4/FOS/JUN/BMP2	9
MF	GO:0140272	exogenous protein binding	9/365	77/18337	2.17637207267669e-05	0.000367716198112666	0.000240069112402714	CCR5/CD4/DAG1/SCARB2/ICAM1/EGFR/CXCR4/HSPA1B/HSPA1A	9
MF	GO:0004714	transmembrane receptor protein tyrosine kinase activity	8/365	61/18337	2.67809507896409e-05	0.000443252063069363	0.000289383850637795	IGF1R/EGFR/KDR/FGFR2/KIT/PDGFRB/NTRK1/ERBB4	8
MF	GO:0061980	regulatory RNA binding	7/365	45/18337	2.76548799781891e-05	0.000448562153246228	0.000292850623769035	MATR3/AGO1/AGO2/MECP2/HNRNPA1/DICER1/SOX2	7
MF	GO:0004497	monooxygenase activity	10/365	101/18337	3.32451643054182e-05	0.000528663299052827	0.000345145875038707	CYP3A5/CYP2D6/CYP2U1/CYP2E1/CYP19A1/CYP1A1/CYP17A1/NOS2/NOS1/DBH	10
MF	GO:0005516	calmodulin binding	14/365	198/18337	4.47355242224893e-05	0.000697702118162286	0.00045550543894559	EEF1A1/EGFR/PLA2G6/FAS/GRIN1/NGFR/KCNQ1/RYR2/CAMK2A/NOS2/TRPV4/SCN5A/NOS1/KCNQ2	14
MF	GO:0005539	glycosaminoglycan binding	15/365	228/18337	5.52879414896918e-05	0.000846009821663019	0.000552330378735153	CEL/PTPRC/APOE/FGFR2/BMP4/THBS4/TLR2/APP/NLRP3/LPL/VEGFA/FBN1/FN1/SHH/MPO	15
MF	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	6/365	35/18337	5.94721156170541e-05	0.000893183069730202	0.000583128151176964	CYP3A5/CYP2D6/CYP2U1/CYP2E1/CYP19A1/CYP1A1	6
MF	GO:0002020	protease binding	11/365	131/18337	6.2978338265022e-05	0.000928644224235143	0.000606279505211599	BCL2/PINK1/GSK3B/IL1R1/SERPINA1/FURIN/CST3/BRCA2/KIT/SERPINE1/FN1	11
MF	GO:0043394	proteoglycan binding	6/365	36/18337	7.01798489179326e-05	0.00101167543410074	0.000660487693364489	COL2A1/PTPRC/APOE/LPL/CTSB/FN1	6
MF	GO:0004879	nuclear receptor activity	7/365	52/18337	7.23516340047382e-05	0.00101167543410074	0.000660487693364489	RORA/PPARA/PPARG/AHR/AR/NR4A1/ESR2	7
MF	GO:0098531	ligand-activated transcription factor activity	7/365	52/18337	7.23516340047382e-05	0.00101167543410074	0.000660487693364489	RORA/PPARA/PPARG/AHR/AR/NR4A1/ESR2	7
MF	GO:0042056	chemoattractant activity	6/365	37/18337	8.23707100410458e-05	0.001132248234632	0.000739205479940162	CCL5/MIF/HMGB1/BMP4/GDNF/VEGFA	6
MF	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	22/365	443/18337	8.54180604156144e-05	0.00115456744995105	0.000753776919106211	KLF4/MEF2C/ATF6/CLOCK/CEBPB/GTF2I/ATF4/SP1/GATA4/PPARA/ETS1/DDIT3/SOX2/ATF3/FOS/AR/JUN/DLX5/SATB2/MYC/NR4A1/EGR1	22
MF	GO:0043177	organic acid binding	10/365	114/18337	9.37368797069983e-05	0.00124623949905534	0.00081362641057153	HBA1/PPARG/P4HTM/HBB/GRIN1/RYR2/GRIN2B/NOS2/NOS1/DBH	10
MF	GO:0070700	BMP receptor binding	4/365	13/18337	9.57719357920862e-05	0.00125251722432554	0.000817724918989873	SRC/BMP4/GDF15/BMP2	4
MF	GO:0001216	DNA-binding transcription activator activity	22/365	447/18337	9.72978854901469e-05	0.00125251722432554	0.000817724918989873	KLF4/MEF2C/ATF6/CLOCK/CEBPB/GTF2I/ATF4/SP1/GATA4/PPARA/ETS1/DDIT3/SOX2/ATF3/FOS/AR/JUN/DLX5/SATB2/MYC/NR4A1/EGR1	22
MF	GO:0030544	Hsp70 protein binding	6/365	39/18337	0.000111790655360328	0.00140210775371776	0.000915387371172737	STUB1/SNCA/CYP2E1/DNAJC10/BAX/CYP1A1	6
MF	GO:0008201	heparin binding	12/365	164/18337	0.000112376083836812	0.00140210775371776	0.000915387371172737	CEL/PTPRC/APOE/FGFR2/BMP4/THBS4/APP/LPL/VEGFA/FBN1/FN1/MPO	12
MF	GO:0035257	nuclear hormone receptor binding	11/365	140/18337	0.000114818251716445	0.00141087275972783	0.000921109738650268	PARP1/CTNNB1/NSD1/EP300/CEBPB/MED12/PPARG/SRC/STAT1/NR4A1/FOXP2	11
MF	GO:0070851	growth factor receptor binding	11/365	141/18337	0.000122356849156513	0.00148106574128257	0.000966936294198369	SRC/IL1R1/IL1RN/IL6/CSF3/APP/PDGFRB/GDNF/VEGFA/IL10/ERBB4	11
MF	GO:0001046	core promoter sequence-specific DNA binding	6/365	40/18337	0.000129334578700231	0.0015425050489101	0.00100704788059158	AGO1/AGO2/CEBPB/FOS/STAT1/MYC	6
MF	GO:0016922	nuclear receptor binding	9/365	97/18337	0.000136065518373099	0.00159615957248552	0.00104207705232035	PARP1/CTNNB1/NSD1/EP300/CEBPB/PPARG/SRC/NR4A1/FOXP2	9
MF	GO:0019207	kinase regulator activity	14/365	220/18337	0.000138511649280377	0.00159615957248552	0.00104207705232035	KLF4/PIK3R2/CCL5/DNAJC3/HSP90AB1/HSPB1/SNCA/HMGB1/CCND1/NRG1/CDKN1A/GHRL/SOCS1/CDKN2A	14
MF	GO:0001223	transcription coactivator binding	5/365	26/18337	0.000141705905325471	0.00159615957248552	0.00104207705232035	RORA/PPARA/AHR/AR/TERT	5
MF	GO:0099604	ligand-gated calcium channel activity	5/365	26/18337	0.000141705905325471	0.00159615957248552	0.00104207705232035	GRIN1/ITPR1/RYR2/GRIN2B/GRIN2A	5
MF	GO:0051879	Hsp90 protein binding	6/365	41/18337	0.00014899137782397	0.00165523297829095	0.00108064402372685	ARNTL/STUB1/CYP2E1/AHR/KDR/CYP1A1	6
MF	GO:0019199	transmembrane receptor protein kinase activity	8/365	80/18337	0.000189935865013441	0.00208159441251217	0.00135900057043756	IGF1R/EGFR/KDR/FGFR2/KIT/PDGFRB/NTRK1/ERBB4	8
MF	GO:0001664	G protein-coupled receptor binding	16/365	289/18337	0.000236697734085849	0.00253119735342417	0.00165253068826317	NPPA/EDNRB/CCL5/EDN1/STUB1/AGTR1/CXCL12/HSPA1B/CCL2/HSPA1A/GHRL/AGT/POMC/C3/UCHL1/NPY	16
MF	GO:1901681	sulfur compound binding	15/365	260/18337	0.000237202218076741	0.00253119735342417	0.00165253068826317	CBS/CEL/PTPRC/APOE/FGFR2/BMP4/THBS4/APP/GSTM1/LPL/RYR2/VEGFA/FBN1/FN1/MPO	15
MF	GO:0015267	channel activity	22/365	477/18337	0.000244186556890248	0.00257188698231158	0.0016790955313164	CYBB/TRPM1/BCL2/P2RX7/GJA1/CFTR/GRIN1/ITPR1/KCNQ1/BAX/RYR2/CNR1/KCNA2/GABRG2/GRIN2B/GJC2/GRIA1/KCNH2/TRPV4/SCN5A/GRIN2A/KCNQ2	22
MF	GO:0022803	passive transmembrane transporter activity	22/365	478/18337	0.000251382340074037	0.00261373176666723	0.00170641453518543	CYBB/TRPM1/BCL2/P2RX7/GJA1/CFTR/GRIN1/ITPR1/KCNQ1/BAX/RYR2/CNR1/KCNA2/GABRG2/GRIN2B/GJC2/GRIA1/KCNH2/TRPV4/SCN5A/GRIN2A/KCNQ2	22
MF	GO:0023026	MHC class II protein complex binding	4/365	17/18337	0.000299302570006282	0.00307258714272272	0.00200598524601146	CD4/HSP90AA1/HSP90AB1/HLA-DRB1	4
MF	GO:0008022	protein C-terminus binding	12/365	185/18337	0.000345096256716023	0.00349841330245868	0.00228399233063368	HRAS/CTNNB1/AGO2/EP300/MED12/ATF4/SP1/PPARG/SRC/BRCA2/TERT/FN1	12
MF	GO:0046873	metal ion transmembrane transporter activity	20/365	425/18337	0.000359220667643474	0.00357759051617458	0.00233568437878618	TRPM1/ATP1A1/ATP7A/MFSD2A/SLC9A6/SLC6A8/GRIN1/ITPR1/KCNQ1/RYR2/CNR1/KCNA2/GRIN2B/KCNH2/TRPV4/SCN5A/SLC6A1/GRIN2A/SLC6A4/KCNQ2	20
MF	GO:0001102	RNA polymerase II activating transcription factor binding	6/365	48/18337	0.000361729250710624	0.00357759051617458	0.00233568437878618	CTNNB1/EP300/GTF2I/CREBBP/FOS/JUN	6
MF	GO:0004713	protein tyrosine kinase activity	10/365	135/18337	0.000375512291681087	0.00366916227172725	0.002395468392081	IGF1R/EIF2AK2/SRC/EGFR/KDR/FGFR2/KIT/PDGFRB/NTRK1/ERBB4	10
MF	GO:0019955	cytokine binding	10/365	136/18337	0.00039829197290879	0.00384541416701225	0.00251053712247019	CCR5/CD4/TNFRSF1A/IL1R1/HMGB1/CXCR4/IL1RN/KIT/LEPR/GHR	10
MF	GO:0019887	protein kinase regulator activity	12/365	190/18337	0.000439337054060395	0.00419179236285859	0.00273667539557125	CCL5/DNAJC3/HSP90AB1/HSPB1/SNCA/HMGB1/CCND1/NRG1/CDKN1A/GHRL/SOCS1/CDKN2A	12
MF	GO:0022836	gated channel activity	17/365	337/18337	0.000450478147824419	0.00420318857428136	0.00274411558551954	CYBB/P2RX7/CFTR/GRIN1/ITPR1/KCNQ1/RYR2/CNR1/KCNA2/GABRG2/GRIN2B/GRIA1/KCNH2/TRPV4/SCN5A/GRIN2A/KCNQ2	17
MF	GO:0017046	peptide hormone binding	6/365	50/18337	0.00045303822622885	0.00420318857428136	0.00274411558551954	EDNRB/IGF1R/LEPR/GHR/CRHR1/CALCR	6
MF	GO:0035198	miRNA binding	5/365	33/18337	0.000456079648010802	0.00420318857428136	0.00274411558551954	MATR3/AGO1/AGO2/HNRNPA1/SOX2	5
MF	GO:0004970	ionotropic glutamate receptor activity	4/365	19/18337	0.000472329391726542	0.00422111066730286	0.00275581629651935	GRIN1/GRIN2B/GRIA1/GRIN2A	4
MF	GO:0015276	ligand-gated ion channel activity	10/365	139/18337	0.000473638804839161	0.00422111066730286	0.00275581629651935	P2RX7/CFTR/GRIN1/ITPR1/RYR2/GABRG2/GRIN2B/GRIA1/KCNH2/GRIN2A	10
MF	GO:0022834	ligand-gated channel activity	10/365	139/18337	0.000473638804839161	0.00422111066730286	0.00275581629651935	P2RX7/CFTR/GRIN1/ITPR1/RYR2/GABRG2/GRIN2B/GRIA1/KCNH2/GRIN2A	10
MF	GO:0097718	disordered domain specific binding	5/365	34/18337	0.000526074341504379	0.00463745968434838	0.00302763608440163	HSP90AA1/HSP90AB1/GJA1/HSPA1A/FN1	5
MF	GO:0072341	modified amino acid binding	8/365	93/18337	0.000533659031865587	0.00465373628863431	0.00303826251305479	CBS/SCARB2/HMGB1/GRAMD1B/MTHFR/GSTM1/NOX4/MME	8
MF	GO:0030506	ankyrin binding	4/365	20/18337	0.000581200089005762	0.00501439651259226	0.00327372502541879	PTPRC/ATP1A1/SCN5A/KCNQ2	4
MF	GO:0016247	channel regulator activity	10/365	145/18337	0.000660046214041079	0.00559748649022162	0.00365440418532218	BCL2/NEDD4L/CFTR/ADRB2/ITPR1/DRD4/CAV1/NOS1/NRXN1/NPY	10
MF	GO:0051082	unfolded protein binding	9/365	120/18337	0.00066786685419415	0.00559748649022162	0.00365440418532218	UGGT1/HSP90AA1/HSP90AB1/SPG7/CANX/PPIB/HSPA1B/HSPA1A/CLU	9
MF	GO:0003712	transcription coregulator activity	21/365	480/18337	0.000669489752837851	0.00559748649022162	0.00365440418532218	DNMT3A/NUPR1/HCFC1/CTNNB1/NSD1/EP300/MED12/MECP2/CREBBP/BRD4/PHF8/ARID1B/KMT2D/HDAC4/KMT2C/BRCA1/HMGB1/CCND1/NRG1/NOTCH1/HSPA1A	21
MF	GO:0044183	protein folding chaperone	5/365	36/18337	0.000689915819512643	0.00570940540433422	0.00372747215053555	HSP90AA1/HSP90AB1/HSPB1/HSPA1B/HSPA1A	5
MF	GO:0120020	cholesterol transfer activity	4/365	21/18337	0.000706758939212141	0.00578971211819239	0.0037799016100341	CETP/GRAMD1B/APOE/ABCA1	4
MF	GO:0032395	MHC class II receptor activity	3/365	10/18337	0.000845950544081472	0.0067611726725827	0.00441413440756583	HLA-DQA1/HLA-DRB1/HLA-DQB1	3
MF	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	4/365	22/18337	0.000850357105552941	0.0067611726725827	0.00441413440756583	RPS6KA3/XIAP/SNCA/BIRC5	4
MF	GO:0120015	sterol transfer activity	4/365	22/18337	0.000850357105552941	0.0067611726725827	0.00441413440756583	CETP/GRAMD1B/APOE/ABCA1	4
MF	GO:0048487	beta-tubulin binding	5/365	38/18337	0.000889186390068342	0.00700126371209151	0.00457088149416838	GABARAP/HTT/VAPB/SPAST/TRPV4	5
MF	GO:0016248	channel inhibitor activity	5/365	39/18337	0.00100350929223128	0.00782544265384203	0.00510895925093458	BCL2/NEDD4L/CFTR/ITPR1/CAV1	5
MF	GO:0004674	protein serine/threonine kinase activity	19/365	430/18337	0.00106287371378187	0.00820943411311521	0.00535965391511059	AKT3/EIF2AK2/PINK1/RPS6KA3/PRKDC/MTOR/GSK3B/BRD4/MAPK1/ATM/MAPK3/PIK3CG/CDKL5/EGFR/DMPK/LRRK2/PRKCA/AURKA/CAMK2A	19
MF	GO:0035197	siRNA binding	3/365	11/18337	0.00114607382619849	0.00876854597214127	0.00572467859560914	AGO2/MECP2/DICER1	3
MF	GO:0070696	transmembrane receptor protein serine/threonine kinase binding	4/365	24/18337	0.00119709990645243	0.00907334601993386	0.00592367194240604	SRC/BMP4/GDF15/BMP2	4
MF	GO:0032934	sterol binding	6/365	60/18337	0.00120840040924807	0.00907419196203873	0.00592422422857483	SCARB2/RORA/CETP/GRAMD1B/ABCA1/CAV1	6
MF	GO:0030331	estrogen receptor binding	5/365	41/18337	0.00126441917421156	0.00932434090413312	0.00608753776984744	PARP1/CTNNB1/NSD1/PPARG/SRC	5
MF	GO:0047485	protein N-terminus binding	8/365	106/18337	0.00126470715099216	0.00932434090413312	0.00608753776984744	STXBP1/PARP1/MECP2/GADD45A/ATM/HSPA1B/HSPA1A/TERT	8
MF	GO:0001221	transcription coregulator binding	6/365	61/18337	0.00131814353291462	0.00954477147494425	0.00623144922045163	KLF4/RORA/PPARA/AHR/AR/TERT	6
MF	GO:0008144	drug binding	6/365	61/18337	0.00131814353291462	0.00954477147494425	0.00623144922045163	HSP90AB1/PPARA/FKBP5/PPIB/CNR1/SLC6A4	6
MF	GO:0070330	aromatase activity	4/365	25/18337	0.00140295860581239	0.0100690214983527	0.00657371382136595	CYP3A5/CYP2E1/CYP19A1/CYP1A1	4
MF	GO:0005035	death receptor activity	3/365	12/18337	0.00150564529745034	0.0106618440557813	0.00696074704401067	TNFRSF1A/FAS/NGFR	3
MF	GO:0099094	ligand-gated cation channel activity	8/365	109/18337	0.00151350934814845	0.0106618440557813	0.00696074704401067	P2RX7/GRIN1/ITPR1/RYR2/GRIN2B/GRIA1/KCNH2/GRIN2A	8
MF	GO:0051117	ATPase binding	7/365	85/18337	0.00152499865656059	0.0106618440557813	0.00696074704401067	ANK2/SRC/EGFR/ABCA1/AR/DNAJC10/CAV1	7
MF	GO:0140375	immune receptor activity	9/365	136/18337	0.0016211434725501	0.0111246062073176	0.0072628683526261	CCR5/CD4/IL1R1/CXCR4/HLA-DQA1/LEPR/HLA-DRB1/GHR/HLA-DQB1	9
MF	GO:0023023	MHC protein complex binding	4/365	26/18337	0.0016322772786282	0.0111246062073176	0.0072628683526261	CD4/HSP90AA1/HSP90AB1/HLA-DRB1	4
MF	GO:0043178	alcohol binding	7/365	86/18337	0.00163234049157928	0.0111246062073176	0.0072628683526261	SCARB2/CETP/GRAMD1B/ABCA1/ITPR1/ASTN2/CAV1	7
MF	GO:0030594	neurotransmitter receptor activity	8/365	111/18337	0.00169987916262817	0.0114883500074287	0.00750034402457867	GRIN1/DRD4/GABRG2/CHRM3/HTR2C/GRIN2B/GRIA1/GRIN2A	8
MF	GO:0019902	phosphatase binding	11/365	193/18337	0.00173093273291155	0.0116015408792667	0.00757424240673782	PIK3R2/BCL2/CTNNB1/MAPK1/PPARA/MAPK3/PPARG/EGFR/PPP1R15A/KCNQ1/CDH2	11
MF	GO:0051219	phosphoprotein binding	7/365	87/18337	0.00174546949892348	0.011603080029729	0.00757524726452554	PIK3R2/PLAT/MTOR/MAPK1/SNCA/MAPK3/SRC	7
MF	GO:0008066	glutamate receptor activity	4/365	27/18337	0.00188639638641832	0.0124379469055712	0.00812030280161246	GRIN1/GRIN2B/GRIA1/GRIN2A	4
MF	GO:0034236	protein kinase A catalytic subunit binding	3/365	13/18337	0.00192860730594781	0.0125128042009894	0.00816917452540419	GSK3B/KCNQ1/RYR2	3
MF	GO:0039706	co-receptor binding	3/365	13/18337	0.00192860730594781	0.0125128042009894	0.00816917452540419	LRRK2/BMP4/BMP2	3
MF	GO:0003713	transcription coactivator activity	13/365	258/18337	0.00207807819521003	0.0133755667961534	0.00873244220710647	NUPR1/HCFC1/CTNNB1/EP300/MED12/CREBBP/BRD4/ARID1B/KMT2D/KMT2C/BRCA1/HMGB1/NOTCH1	13
MF	GO:0033612	receptor serine/threonine kinase binding	4/365	28/18337	0.00216664389318734	0.0138358125777554	0.00903292066533967	SRC/BMP4/GDF15/BMP2	4
MF	GO:0070888	E-box binding	5/365	47/18337	0.00234834155313727	0.0148789453093306	0.00971394573378327	ARNTL/CLOCK/PPARG/AHR/MYC	5
MF	GO:0099106	ion channel regulator activity	8/365	117/18337	0.0023697856534965	0.0148984198836098	0.00972666000578327	NEDD4L/CFTR/ADRB2/ITPR1/DRD4/CAV1/NRXN1/NPY	8
MF	GO:0050998	nitric-oxide synthase binding	3/365	14/18337	0.00241859642481929	0.0149731427521255	0.00977544396692731	CAV1/SCN5A/SLC6A4	3
MF	GO:0071837	HMG box domain binding	3/365	14/18337	0.00241859642481929	0.0149731427521255	0.00977544396692731	SP1/JUN/DLX5	3
MF	GO:0051059	NF-kappaB binding	4/365	29/18337	0.00247433235906036	0.015125383426962	0.00987483660686858	NFKBIA/EP300/GSK3B/CDKN2A	4
MF	GO:0004860	protein kinase inhibitor activity	6/365	69/18337	0.00249223154475195	0.015125383426962	0.00987483660686858	DNAJC3/HSPB1/SNCA/CDKN1A/SOCS1/CDKN2A	6
MF	GO:0005262	calcium channel activity	8/365	118/18337	0.00249913856869656	0.015125383426962	0.00987483660686858	TRPM1/GRIN1/ITPR1/RYR2/CNR1/GRIN2B/TRPV4/GRIN2A	8
MF	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	5/365	48/18337	0.002579342983652	0.0154951641462354	0.0101162535733096	CYP2D6/CYP2E1/CYP1A1/NOS2/NOS1	5
MF	GO:0032813	tumor necrosis factor receptor superfamily binding	5/365	49/18337	0.00282638415480993	0.0168543937466975	0.0110036472900108	NGF/FASLG/STAT1/TNFSF11/CD40LG	5
MF	GO:0005261	cation channel activity	15/365	333/18337	0.00289652007472722	0.0171465531430933	0.0111943879952961	TRPM1/P2RX7/GRIN1/ITPR1/KCNQ1/RYR2/CNR1/KCNA2/GRIN2B/GRIA1/KCNH2/TRPV4/SCN5A/GRIN2A/KCNQ2	15
MF	GO:0005161	platelet-derived growth factor receptor binding	3/365	15/18337	0.0029789564636444	0.017506765884171	0.0114295583616562	IL1R1/PDGFRB/VEGFA	3
MF	GO:0015485	cholesterol binding	5/365	50/18337	0.0030900892579856	0.0180292258145779	0.0117706542731296	SCARB2/CETP/GRAMD1B/ABCA1/CAV1	5
MF	GO:0005164	tumor necrosis factor receptor binding	4/365	31/18337	0.00317718943226068	0.0181457790814325	0.0118467478460128	FASLG/STAT1/TNFSF11/CD40LG	4
MF	GO:0031210	phosphatidylcholine binding	4/365	31/18337	0.00317718943226068	0.0181457790814325	0.0118467478460128	NF1/SCARB2/CETP/ABCA1	4
MF	GO:0050997	quaternary ammonium group binding	4/365	31/18337	0.00317718943226068	0.0181457790814325	0.0118467478460128	NF1/SCARB2/CETP/ABCA1	4
MF	GO:0005230	extracellular ligand-gated ion channel activity	6/365	73/18337	0.00331243214662291	0.0186554338257721	0.0121794836970126	P2RX7/GRIN1/GABRG2/GRIN2B/GRIA1/GRIN2A	6
MF	GO:0019210	kinase inhibitor activity	6/365	73/18337	0.00331243214662291	0.0186554338257721	0.0121794836970126	DNAJC3/HSPB1/SNCA/CDKN1A/SOCS1/CDKN2A	6
MF	GO:0004867	serine-type endopeptidase inhibitor activity	7/365	98/18337	0.00343368472092409	0.0192049538528927	0.0125382462041729	SERPINA1/FURIN/SERPINA3/APP/SERPINI1/SERPINE1/AGT	7
MF	GO:0001530	lipopolysaccharide binding	4/365	32/18337	0.00357488290676061	0.0195329406114849	0.0127523773477538	P2RX7/CD14/HMGB1/TLR2	4
MF	GO:0003953	NAD+ nucleosidase activity	3/365	16/18337	0.00361275103788253	0.0195329406114849	0.0127523773477538	IL1R1/TLR2/IL1RAPL1	3
MF	GO:0042800	histone methyltransferase activity (H3-K4 specific)	3/365	16/18337	0.00361275103788253	0.0195329406114849	0.0127523773477538	KMT2A/KMT2D/KMT2C	3
MF	GO:0050135	NAD(P)+ nucleosidase activity	3/365	16/18337	0.00361275103788253	0.0195329406114849	0.0127523773477538	IL1R1/TLR2/IL1RAPL1	3
MF	GO:0061809	NAD+ nucleotidase, cyclic ADP-ribose generating	3/365	16/18337	0.00361275103788253	0.0195329406114849	0.0127523773477538	IL1R1/TLR2/IL1RAPL1	3
MF	GO:0004601	peroxidase activity	5/365	53/18337	0.0039874254477608	0.0213691172539672	0.0139511531945558	HBA1/PTGS1/PRDX1/HBB/MPO	5
MF	GO:0005251	delayed rectifier potassium channel activity	4/365	33/18337	0.00400506266658818	0.0213691172539672	0.0139511531945558	KCNQ1/KCNA2/KCNH2/KCNQ2	4
MF	GO:0003725	double-stranded RNA binding	6/365	76/18337	0.00404829851115573	0.0214586280558647	0.0140095916829125	EIF2AK2/AGO1/AGO2/HSP90AB1/DICER1/HMGB1	6
MF	GO:0106311	protein threonine kinase activity	12/365	248/18337	0.00421130950390074	0.0221777403095032	0.0144790750544229	AKT3/EIF2AK2/PINK1/RPS6KA3/PRKDC/MTOR/GSK3B/ATM/PIK3CG/DMPK/LRRK2/AURKA	12
MF	GO:0005324	long-chain fatty acid transporter activity	3/365	17/18337	0.0043227757095703	0.0224583193650037	0.0146622553580335	ABCD1/MFSD2A/SLC2A1	3
MF	GO:0043395	heparan sulfate proteoglycan binding	3/365	17/18337	0.0043227757095703	0.0224583193650037	0.0146622553580335	PTPRC/APOE/LPL	3
MF	GO:0106310	protein serine kinase activity	12/365	249/18337	0.00434766478459382	0.0224583193650037	0.0146622553580335	AKT3/EIF2AK2/PINK1/RPS6KA3/PRKDC/MTOR/GSK3B/ATM/PIK3CG/DMPK/LRRK2/AURKA	12
MF	GO:0015248	sterol transporter activity	4/365	34/18337	0.00446892777659935	0.0229386102963422	0.0149758205971317	CETP/GRAMD1B/APOE/ABCA1	4
MF	GO:0050840	extracellular matrix binding	5/365	55/18337	0.00468037717695329	0.0238728672359064	0.0155857644489077	SPP1/DAG1/ELN/VEGFA/SHH	5
MF	GO:0004869	cysteine-type endopeptidase inhibitor activity	5/365	56/18337	0.00505711997266754	0.0255894014604258	0.0167064299235436	RPS6KA3/XIAP/SNCA/CST3/BIRC5	5
MF	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	3/365	18/18337	0.00511156971219356	0.0255894014604258	0.0167064299235436	CEBPB/FOS/STAT1	3
MF	GO:0004708	MAP kinase kinase activity	3/365	18/18337	0.00511156971219356	0.0255894014604258	0.0167064299235436	MAPK1/MAPK3/LRRK2	3
MF	GO:0015085	calcium ion transmembrane transporter activity	8/365	134/18337	0.00542170676211817	0.0269749145562045	0.0176109832198986	TRPM1/GRIN1/ITPR1/RYR2/CNR1/GRIN2B/TRPV4/GRIN2A	8
MF	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	5/365	57/18337	0.00545485325180953	0.0269749145562045	0.0176109832198986	HBA1/PTGS1/PRDX1/HBB/MPO	5
MF	GO:0050660	flavin adenine dinucleotide binding	6/365	81/18337	0.00553398324031971	0.0272003661084805	0.0177581726946144	CYBB/MTHFR/NOX4/NOS2/XDH/NOS1	6
MF	GO:0005216	ion channel activity	17/365	429/18337	0.00575428485831877	0.0281128013258826	0.0183538699031981	TRPM1/P2RX7/CFTR/GRIN1/ITPR1/KCNQ1/RYR2/CNR1/KCNA2/GABRG2/GRIN2B/GRIA1/KCNH2/TRPV4/SCN5A/GRIN2A/KCNQ2	17
MF	GO:0042626	ATPase-coupled transmembrane transporter activity	5/365	58/18337	0.00587418015888067	0.0285267072386361	0.018624094673287	ABCD1/ATP1A1/ATP7A/CFTR/ABCA1	5
MF	GO:0030296	protein tyrosine kinase activator activity	3/365	19/18337	0.00598142727228112	0.0288746280822618	0.0188512400874524	CCL5/NRG1/GHRL	3
MF	GO:0071855	neuropeptide receptor binding	4/365	37/18337	0.00607418586135495	0.029148903748869	0.019030305127758	NPPA/EDN1/POMC/NPY	4
MF	GO:0005244	voltage-gated ion channel activity	10/365	197/18337	0.00624195301225832	0.0296036484967339	0.0193271921524527	CYBB/GRIN1/KCNQ1/CNR1/KCNA2/GRIN2B/KCNH2/SCN5A/GRIN2A/KCNQ2	10
MF	GO:0022832	voltage-gated channel activity	10/365	197/18337	0.00624195301225832	0.0296036484967339	0.0193271921524527	CYBB/GRIN1/KCNQ1/CNR1/KCNA2/GRIN2B/KCNH2/SCN5A/GRIN2A/KCNQ2	10
MF	GO:0022824	transmitter-gated ion channel activity	5/365	59/18337	0.00631569804438462	0.0296071162658724	0.0193294561382748	GRIN1/GABRG2/GRIN2B/GRIA1/GRIN2A	5
MF	GO:0022835	transmitter-gated channel activity	5/365	59/18337	0.00631569804438462	0.0296071162658724	0.0193294561382748	GRIN1/GABRG2/GRIN2B/GRIA1/GRIN2A	5
MF	GO:0008200	ion channel inhibitor activity	4/365	38/18337	0.00668418579915338	0.030976426760648	0.0202234313201453	NEDD4L/CFTR/ITPR1/CAV1	4
MF	GO:0042169	SH2 domain binding	4/365	38/18337	0.00668418579915338	0.030976426760648	0.0202234313201453	DAG1/SRC/KIT/TRPV4	4
MF	GO:0022843	voltage-gated cation channel activity	8/365	139/18337	0.00672913374367969	0.0310075424211604	0.0202437456523378	GRIN1/KCNQ1/CNR1/KCNA2/GRIN2B/KCNH2/GRIN2A/KCNQ2	8
MF	GO:0005507	copper ion binding	5/365	60/18337	0.00677999782939703	0.0310654137832824	0.0202815278512442	ATP7A/ATP13A2/SNCA/CP/DBH	5
MF	GO:0035014	phosphatidylinositol 3-kinase regulator activity	3/365	20/18337	0.00693440853991795	0.0313819588938247	0.0204881891408837	KLF4/PIK3R2/SOCS1	3
MF	GO:0070182	DNA polymerase binding	3/365	20/18337	0.00693440853991795	0.0313819588938247	0.0204881891408837	HSP90AA1/HSP90AB1/HMGB1	3
MF	GO:0045296	cadherin binding	14/365	332/18337	0.00696516966817318	0.0313819588938247	0.0204881891408837	HCFC1/CTNNB1/HSP90AB1/VAPB/RTN4/SRC/EGFR/PRDX1/KDR/STAT1/EPCAM/ANK3/HSPA1A/CDH2	14
MF	GO:0015631	tubulin binding	15/365	368/18337	0.00719091067703146	0.0322200472876935	0.0210353478950092	GABARAP/MAP1LC3A/DAG1/HTT/VAPB/GJA1/SNCA/BCL2L11/BRCA1/ALMS1/SPAST/LRRK2/BRCA2/BIRC5/TRPV4	15
MF	GO:0015399	primary active transmembrane transporter activity	5/365	61/18337	0.00726766339158296	0.0323850275306252	0.021143057755733	ABCD1/ATP1A1/ATP7A/CFTR/ABCA1	5
MF	GO:0016887	ATPase activity	18/365	478/18337	0.00759602320578029	0.0336632503819006	0.0219775649842248	ABCD1/ATP1A1/ATP7A/ATP13A2/BCS1L/HSP90AA1/SETX/DYNC1H1/MFSD2A/CHD7/DICER1/SPAST/SPG7/CFTR/ABCA1/HSPA1B/HSPA1A/ACSL4	18
MF	GO:0043028	cysteine-type endopeptidase regulator activity involved in apoptotic process	4/365	40/18337	0.00802285203550734	0.0353615923956329	0.0230863533973695	RPS6KA3/XIAP/SNCA/BIRC5	4
MF	GO:0005158	insulin receptor binding	3/365	22/18337	0.00909687535600652	0.0396643328694693	0.025895462954563	IGF1R/SRC/IGF1	3
MF	GO:0070412	R-SMAD binding	3/365	22/18337	0.00909687535600652	0.0396643328694693	0.025895462954563	PARP1/FOS/JUN	3
MF	GO:0005543	phospholipid binding	17/365	451/18337	0.00924780424599065	0.0401067873983873	0.0261843261229006	MAP1LC3A/BSCL2/ZFYVE26/ATP13A2/NF1/SCARB2/WDR45/SNCA/CETP/HMGB1/GRAMD1B/APOE/ABCA1/ITPR1/KCNQ1/PLA2G4A/MME	17
MF	GO:0019903	protein phosphatase binding	8/365	148/18337	0.00966629437393411	0.0416987486024498	0.0272236622065446	PIK3R2/BCL2/CTNNB1/PPARG/EGFR/PPP1R15A/KCNQ1/CDH2	8
MF	GO:0002039	p53 binding	5/365	66/18337	0.0100763477632266	0.0432376615660146	0.0282283649395877	EP300/HTT/GSK3B/CREBBP/BRD4	5
MF	GO:0004402	histone acetyltransferase activity	4/365	43/18337	0.0103420540852263	0.0436844055370757	0.0285200285354651	EP300/CLOCK/CREBBP/BRCA2	4
MF	GO:0016504	peptidase activator activity	4/365	43/18337	0.0103420540852263	0.0436844055370757	0.0285200285354651	PINK1/APP/CAV1/FN1	4
MF	GO:0018024	histone-lysine N-methyltransferase activity	4/365	43/18337	0.0103420540852263	0.0436844055370757	0.0285200285354651	NSD1/KMT2A/KMT2D/KMT2C	4
MF	GO:0004712	protein serine/threonine/tyrosine kinase activity	4/365	44/18337	0.0112017244062901	0.0470704585155505	0.0307306647197377	MAPK1/MAPK3/LRRK2/AURKA	4
MF	GO:0010857	calcium-dependent protein kinase activity	3/365	24/18337	0.0116111616782175	0.0485394439228576	0.0316897141841747	PINK1/PRKCA/CAMK2A	3
MF	GO:0001098	basal transcription machinery binding	5/365	69/18337	0.0120774481671215	0.0498377658091445	0.0325373433733528	AGO1/AGO2/BRD4/AHR/AR	5
MF	GO:0001099	basal RNA polymerase II transcription machinery binding	5/365	69/18337	0.0120774481671215	0.0498377658091445	0.0325373433733528	AGO1/AGO2/BRD4/AHR/AR	5
MF	GO:0061733	peptide-lysine-N-acetyltransferase activity	4/365	45/18337	0.0121060910781769	0.0498377658091445	0.0325373433733528	EP300/CLOCK/CREBBP/BRCA2	4