{"text_format":"3","workbook":"xls","n_sheets":1,"sheets":["Table S5"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Table S5","index":0,"n_rows":277,"n_cols":9,"rows_kept":277,"flags":["formulas_cached_only"]}
["Table S5 KEGG enrichment analysis"]
["ID","Description","Gene ratio","Background ratio","P value","Adjusted P value","q value","Gene ID","Count"]
["hsa04640","Hematopoietic cell lineage","34/468","99/8113",{"v":2.75259323538373e-18,"d":"2.75E-18"},{"v":7.56963139730526e-16,"d":"7.57E-16"},{"v":5.93980645530174e-16,"d":"5.94E-16"},"ITGA5/CSF1R/CR1/ANPEP/CD14/IL7R/CD37/ITGAM/FCER2/CSF1/CD33/IL2RA/ITGB3/CD22/FCGR1A/CSF2RA/CD4/CR2/MS4A1/ITGA4/HLA-DQA1/HLA-DMB/IL6/CSF3R/IL9R/CD19/CD3E/HLA-DPB1/CD2/CSF3/HLA-DQB1/CD8A/CD38/CD36",34]
["hsa04514","Cell adhesion molecules","36/468","149/8113",{"v":7.23971112032035e-14,"d":"7.24E-14"},{"v":9.95460279044048e-12,"d":"9.95E-12"},{"v":7.81126726139827e-12,"d":"7.81E-12"},"NCAM1/SIGLEC1/JAM3/NEGR1/CADM3/SELPLG/ITGB2/NRXN2/ITGAM/CD22/CD4/CD28/ITGAL/VCAM1/ITGA4/PDCD1LG2/HLA-DQA1/SPN/HLA-DMB/ICAM1/CD86/CDH2/CD6/HLA-DPB1/VCAN/PDCD1/CD2/ICOS/HLA-DQB1/CD8A/NCAM2/CLDN9/CLDN18/CLDN3/CLDN6/CNTNAP2",36]
["hsa05150","Staphylococcus aureus infection","28/468","96/8113",{"v":3.11427990998682e-13,"d":"3.11E-13"},{"v":2.85475658415459e-11,"d":"2.85E-11"},{"v":2.24009607560455e-11,"d":"2.24E-11"},"C1QC/C1QB/C1QA/C1R/SELPLG/ITGB2/FCGR2A/C3AR1/FCGR3A/ITGAM/FPR1/C1S/FCGR1A/ITGAL/C5AR1/HLA-DQA1/HLA-DMB/ICAM1/FPR3/HLA-DPB1/FCGR2B/FCGR3B/HLA-DQB1/FPR2/KRT13/KRT24/KRT14/KRT31",28]
["hsa04061","Viral protein interaction with cytokine and cytokine receptor","27/468","100/8113",{"v":6.35099926020125e-12,"d":"6.35E-12"},{"v":4.36631199138836e-10,"d":"4.37E-10"},{"v":3.42619696931909e-10,"d":"3.43E-10"},"CSF1R/CXCL12/IL10RA/CSF1/IL2RA/CXCL11/CXCR4/CCL19/CCL13/CXCL9/CXCL13/IL24/IL6/CXCL10/IL2RB/CCR1/CCR5/CCL4/CXCR3/CCL2/CCL3/CCL8/CCL5/CCR4/CCL18/CXCL5/CCL21",27]
["hsa04060","Cytokine-cytokine receptor interaction","49/468","295/8113",{"v":9.44645606416302e-12,"d":"9.45E-12"},{"v":5.19555083528966e-10,"d":"5.20E-10"},{"v":4.07689156453351e-10,"d":"4.08E-10"},"CSF1R/CD70/CXCL12/TGFB3/IL10RA/IL16/IL7R/CSF1/IL2RA/TNFRSF9/IL27RA/CXCL11/CSF2RA/IL21R/CD4/TNFSF13B/TNFSF8/OSMR/CXCR4/CCL19/CCL13/CXCL9/CXCL13/EBI3/IL24/IL6/CXCL10/CSF3R/CD27/IL32/IL2RB/CCR1/IL9R/CCR5/TNFRSF8/CCL4/IL12RB1/CXCR3/CCL2/CCL3/CSF3/CCL8/CCL5/IL",49]
["hsa04610","Complement and coagulation cascades","22/468","85/8113",{"v":1.43795887333545e-09,"d":"1.44E-09"},{"v":6.5906448361208e-08,"d":"6.59E-08"},{"v":5.17160647427661e-08,"d":"5.17E-08"},"CR1/F13A1/C1QC/VSIG4/C1QB/C1QA/ITGAX/C1R/ITGB2/C3AR1/ITGAM/C1S/A2M/CR2/C5AR1/SERPINA5/C7/F2RL2/BDKRB1/VTN/F3/SERPINA1",22]
["hsa04145","Phagosome","29/468","152/8113",{"v":8.04903472229323e-09,"d":"8.05E-09"},{"v":3.16212078375806e-07,"d":"3.16E-07"},{"v":2.48128138055656e-07,"d":"2.48E-07"},"CD209/ITGA5/MRC1/COLEC12/CYBB/CORO1A/OLR1/CD14/C1R/ITGB2/FCGR2A/FCGR3A/THBS4/ITGAM/NCF1/ITGB3/FCGR1A/NCF2/THBS1/HLA-DQA1/HLA-DMB/HLA-DPB1/FCGR2B/MARCO/COMP/FCGR3B/HLA-DQB1/CD36/TUBA3C",29]
["hsa04380","Osteoclast differentiation","25/468","128/8113",{"v":5.44486308867799e-08,"d":"5.44E-08"},{"v":1.87167168673306e-06,"d":"1.87E-06"},{"v":1.46868017523551e-06,"d":"1.47E-06"},"LILRB5/CSF1R/SIRPA/BTK/SPI1/PIK3CD/LCP2/LILRB2/FCGR2A/LILRA5/NFATC1/FCGR3A/TYROBP/LILRB3/NCF1/CSF1/ITGB3/OSCAR/FCGR1A/AKT3/CTSK/LILRA6/NCF2/FCGR2B/FCGR3B",25]
["hsa04974","Protein digestion and absorption","22/468","103/8113",{"v":6.5242696055885e-08,"d":"6.52E-08"},{"v":1.98454233835527e-06,"d":"1.98E-06"},{"v":1.55724853344624e-06,"d":"1.56E-06"},"XPNPEP2/COL6A1/COL6A2/COL16A1/ATP1A2/COL14A1/SLC7A7/COL6A3/COL5A3/COL5A1/COL8A2/COL5A2/COL23A1/COL15A1/CPA3/ELN/COL11A1/COL4A4/COL9A1/COL10A1/COL2A1/CPB1",22]
["hsa05144","Malaria","15/468","50/8113",{"v":7.21651759401917e-08,"d":"7.22E-08"},{"v":1.98454233835527e-06,"d":"1.98E-06"},{"v":1.55724853344624e-06,"d":"1.56E-06"},"CR1/GYPC/TGFB3/ITGB2/THBS4/ITGAL/VCAM1/THBS1/ICAM1/IL6/HGF/CCL2/COMP/CSF3/CD36",15]
["hsa04510","Focal adhesion","32/468","201/8113",{"v":1.24623271459186e-07,"d":"1.25E-07"},{"v":3.11558178647964e-06,"d":"3.12E-06"},{"v":2.44476274154383e-06,"d":"2.44E-06"},"FLNC/MYLK/ITGA7/ITGA5/MYL9/COL6A1/COL6A2/PPP1R12B/FLNA/PIK3CD/THBS4/PDGFRB/ITGB3/COL6A3/AKT3/PARVG/TNC/CAV1/ITGA4/THBS1/FN1/LAMA1/HGF/ITGA11/CCND2/IGF1/COL4A4/BIRC3/COMP/COL9A1/VTN/COL2A1",32]
["hsa05323","Rheumatoid arthritis","20/468","93/8113",{"v":2.31214537556774e-07,"d":"2.31E-07"},{"v":5.29866648567608e-06,"d":"5.30E-06"},{"v":4.15780528062621e-06,"d":"4.16E-06"},"CXCL12/TGFB3/ITGB2/CSF1/CTSK/TNFSF13B/CD28/ITGAL/MMP3/HLA-DQA1/HLA-DMB/ICAM1/IL6/CD86/HLA-DPB1/CCL2/CCL3/CCL5/HLA-DQB1/CXCL5",20]
["hsa04512","ECM-receptor interaction","19/468","88/8113",{"v":4.34937970797334e-07,"d":"4.35E-07"},{"v":9.20061092071284e-06,"d":"9.20E-06"},{"v":7.21961813874118e-06,"d":"7.22E-06"},"ITGA7/ITGA5/COL6A1/COL6A2/THBS4/ITGB3/COL6A3/TNC/ITGA4/THBS1/FN1/LAMA1/ITGA11/COL4A4/COMP/COL9A1/VTN/COL2A1/CD36",19]
["hsa04062","Chemokine signaling pathway","30/468","192/8113",{"v":4.72840640611216e-07,"d":"4.73E-07"},{"v":9.28794115486318e-06,"d":"9.29E-06"},{"v":7.28814521242852e-06,"d":"7.29E-06"},"RASGRP2/DOCK2/WAS/CXCL12/GNG2/PIK3CD/PIK3R5/NCF1/CXCL11/AKT3/CXCR4/CCL19/CCL13/CXCL9/CXCL13/ITK/PIK3CG/CXCL10/CCR1/CCR5/CCL4/CXCR3/CCL2/CCL3/CCL8/CCL5/CCR4/CCL18/CXCL5/CCL21",30]
["hsa05410","Hypertrophic cardiomyopathy","19/468","90/8113",{"v":6.29293523226357e-07,"d":"6.29E-07"},{"v":1.15370479258165e-05,"d":"1.15E-05"},{"v":9.05299454465987e-06,"d":"9.05E-06"},"ITGA7/ITGA5/CACNA1C/TPM1/SGCA/ACTC1/TPM2/TGFB3/DES/ITGB3/SGCD/DMD/ITGA4/IL6/LAMA1/RYR2/ITGA11/IGF1/TNNC1",19]
["hsa05416","Viral myocarditis","15/468","60/8113",{"v":9.98017782171935e-07,"d":"9.98E-07"},{"v":1.71534306310801e-05,"d":"1.72E-05"},{"v":1.34601082463978e-05,"d":"1.35E-05"},"SGCA/ITGB2/CD28/SGCD/ITGAL/CAV1/DMD/HLA-DQA1/HLA-DMB/ICAM1/CD86/LAMA1/PRF1/HLA-DPB1/HLA-DQB1",15]
["hsa05140","Leishmaniasis","17/468","77/8113",{"v":1.26849246978434e-06,"d":"1.27E-06"},{"v":2.05197311288643e-05,"d":"2.05E-05"},{"v":1.61016072015969e-05,"d":"1.61E-05"},"CR1/CYBB/TGFB3/ITGB2/FCGR2A/FCGR3A/ITGAM/NCF1/FCGR1A/NCF2/ITGA4/HLA-DQA1/HLA-DMB/HLA-DPB1/FCGR3B/HLA-DQB1/EEF1A2",17]
["hsa04670","Leukocyte transendothelial migration","21/468","114/8113",{"v":1.75214690278086e-06,"d":"1.75E-06"},{"v":2.57701199313554e-05,"d":"2.58E-05"},{"v":2.02215295155133e-05,"d":"2.02E-05"},"JAM3/MYL9/CYBB/CXCL12/PIK3CD/ITGB2/ITGAM/RHOH/NCF1/NCF2/ITGAL/VCAM1/ITGA4/CXCR4/ITK/ICAM1/MMP9/CLDN9/CLDN18/CLDN3/CLDN6",21]
["hsa05414","Dilated cardiomyopathy","19/468","96/8113",{"v":1.7804810134391e-06,"d":"1.78E-06"},{"v":2.57701199313554e-05,"d":"2.58E-05"},{"v":2.02215295155133e-05,"d":"2.02E-05"},"ITGA7/ITGA5/CACNA1C/TPM1/SGCA/PLN/ACTC1/TPM2/TGFB3/DES/ITGB3/SGCD/DMD/ITGA4/LAMA1/RYR2/ITGA11/IGF1/TNNC1",19]
["hsa04662","B cell receptor signaling pathway","17/468","82/8113",{"v":3.20302255459212e-06,"d":"3.20E-06"},{"v":4.40415601256417e-05,"d":"4.40E-05"},{"v":3.45589275627045e-05,"d":"3.46E-05"},"LILRB5/BTK/PIK3CD/LILRB2/LILRA5/PIK3AP1/NFATC1/LILRB3/CD22/AKT3/LILRA6/CD79B/CR2/CD72/CD19/FCGR2B/CD79A",17]
["hsa04151","PI3K-Akt signaling pathway","42/468","354/8113",{"v":5.39768098949157e-06,"d":"5.40E-06"},{"v":7.06839177195325e-05,"d":"7.07E-05"},{"v":5.54648923732217e-05,"d":"5.55E-05"},"ITGA7/ITGA5/FGF2/CSF1R/COL6A1/COL6A2/CREB5/FGF7/GNG2/PIK3CD/IL7R/PIK3AP1/THBS4/CHRM2/PIK3R5/CSF1/IL2RA/PDGFRB/ITGB3/COL6A3/AKT3/TNC/ITGA4/OSMR/THBS1/FN1/PIK3CG/IL6/LAMA1/CSF3R/HGF/IL2RB/ITGA11/CD19/CCND2/IGF1/COL4A4/COMP/CSF3/COL9A1/VTN/COL2A1",42]
["hsa05152","Tuberculosis","26/468","180/8113",{"v":1.20991855425685e-05,"d":"1.21E-05"},0.000151239819282107,0.000118676221829021,"CD209/CR1/MRC1/CORO1A/TGFB3/IL10RA/CD14/ITGAX/ITGB2/FCGR2A/FCGR3A/ITGAM/FCER1G/FCGR1A/AKT3/SPHK1/TLR1/HLA-DQA1/HLA-DMB/IL6/HLA-DPB1/FCGR2B/CLEC4E/FCGR3B/HLA-DQB1/LBP",26]
["hsa04672","Intestinal immune network for IgA production","12/468","49/8113",{"v":1.53466801763278e-05,"d":"1.53E-05"},0.000183492915151746,0.000143984871219552,"CXCL12/TNFSF13B/CD28/ITGA4/CXCR4/HLA-DQA1/HLA-DMB/IL6/CD86/HLA-DPB1/ICOS/HLA-DQB1",12]
["hsa05133","Pertussis","15/468","76/8113",{"v":2.26591767626626e-05,"d":"2.27E-05"},0.000259636400405509,0.000203733826155519,"CFL2/ITGA5/IRF8/C1QC/C1QB/C1QA/CD14/C1R/ITGB2/ITGAM/C1S/NLRP3/LY96/IL6/CXCL5",15]
["hsa05332","Graft-versus-host disease","10/468","42/8113",0.000102342315833507,0.00112576547416858,0.000883375778773432,"CD28/HLA-DQA1/HLA-DMB/IL6/CD86/PRF1/HLA-DPB1/KLRD1/HLA-DQB1/GZMB",10]
["hsa05412","Arrhythmogenic right ventricular cardiomyopathy","14/468","77/8113",0.00010873808468872,0.00115011435728454,0.000902482079400311,"ITGA7/ITGA5/CACNA1C/SGCA/DES/ITGB3/SGCD/DMD/ITGA4/LAMA1/RYR2/ITGA11/ACTN2/CDH2",14]
["hsa04620","Toll-like receptor signaling pathway","16/468","104/8113",0.000277185876799119,0.00282318948591696,0.00221532572100661,"PIK3CD/CD14/CXCL11/AKT3/CTSK/TLR8/LY96/TLR1/CXCL9/IL6/CXCL10/CD86/CCL4/CCL3/CCL5/LBP",16]
["hsa04630","JAK-STAT signaling pathway","21/468","162/8113",0.000388320345805381,0.00381386053915999,0.00299269439436478,"FHL1/AOX1/PIK3CD/IL10RA/IL7R/IL2RA/PDGFRB/IL27RA/AKT3/CSF2RA/IL21R/OSMR/IL24/IL6/CSF3R/IL2RB/IL9R/CCND2/IL12RB1/CSF3/IL12RB2",21]
["hsa04613","Neutrophil extracellular trap formation","23/468","190/8113",0.000564305558200314,0.00535117339672712,0.0041990068759007,"CR1/CYBB/PIK3CD/SELPLG/ITGB2/FCGR2A/FCGR3A/ITGAM/FPR1/NCF1/ITGB3/FCGR1A/CTSG/AKT3/NCF2/SIGLEC9/TLR8/ITGAL/C5AR1/FPR3/HDAC9/FCGR3B/FPR2",23]
["hsa04940","Type I diabetes mellitus","9/468","43/8113",0.000635169944390138,0.005805633151125,0.00455561644394498,"PTPRN/CD28/HLA-DQA1/HLA-DMB/CD86/PRF1/HLA-DPB1/HLA-DQB1/GZMB",9]
["hsa05202","Transcriptional misregulation in cancer","23/468","192/8113",0.000654453191581364,0.005805633151125,0.00455561644394498,"ZEB1/CSF1R/SPI1/RUNX1T1/CD14/ITGAM/FCGR1A/MMP3/BCL2A1/PAX5/IL6/CD86/IL2RB/CCND2/TSPAN7/IGF1/BIRC3/EYA1/GZMB/MMP9/HMGA2/PROM1/CCNA1",23]
["hsa04810","Regulation of actin cytoskeleton","25/468","218/8113",0.000743195474189492,0.00634744886182412,0.00498077326956534,"CFL2/MYLK/ITGA7/NCKAP1L/ITGA5/FGF2/MYH11/MYL9/PPP1R12B/CXCL12/FGF7/PIK3CD/ITGAX/ITGB2/ITGAM/CHRM2/PDGFRB/ITGB3/IQGAP2/ITGAL/ITGA4/CXCR4/FN1/ITGA11/BDKRB1",25]
["hsa00982","Drug metabolism - cytochrome P450","12/468","72/8113",0.000761693863418894,0.00634744886182412,0.00498077326956534,"AOX1/UGT1A1/FMO1/ADH1B/FMO2/CYP2C9/UGT2B15/ADH6/CYP1A2/ADH1C/UGT1A10/GSTM1",12]
["hsa05330","Allograft rejection","8/468","38/8113",0.00121599820475873,0.00955427160881856,0.00749713178873801,"CD28/HLA-DQA1/HLA-DMB/CD86/PRF1/HLA-DPB1/HLA-DQB1/GZMB",8]
["hsa05340","Primary immunodeficiency","8/468","38/8113",0.00121599820475873,0.00955427160881856,0.00749713178873801,"BTK/IL7R/CD4/CD19/CD3E/ICOS/CD79A/CD8A",8]
["hsa04659","Th17 cell differentiation","15/468","108/8113",0.00127440781224864,0.00973505967689934,0.00763899419622724,"NFATC1/IL2RA/IL27RA/IL21R/CD4/EBI3/HLA-DQA1/HLA-DMB/IL6/IL2RB/CD3E/IL12RB1/HLA-DPB1/IRF4/HLA-DQB1",15]
["hsa00830","Retinol metabolism","11/468","68/8113",0.00161051394775239,0.0119700360981596,0.00939275559855589,"AOX1/CYP26B1/UGT1A1/ADH1B/CYP2C9/UGT2B15/ADH6/CYP1A1/CYP1A2/ADH1C/UGT1A10",11]
["hsa05322","Systemic lupus erythematosus","17/468","136/8113",0.00203330277782351,0.0147146911553018,0.0115464562175574,"C1QC/C1QB/C1QA/C1R/FCGR2A/FCGR3A/C1S/FCGR1A/CTSG/CD28/HLA-DQA1/HLA-DMB/CD86/C7/HLA-DPB1/FCGR3B/HLA-DQB1",17]
["hsa04064","NF-kappa B signaling pathway","14/468","104/8113",0.00246976356647066,0.0174149995071649,0.0136653584649524,"BTK/CXCL12/CD14/TNFSF13B/VCAM1/LY96/CCL19/CCL13/BCL2A1/ICAM1/CCL4/BIRC3/LBP/CCL21",14]
["hsa04020","Calcium signaling pathway","25/468","240/8113",0.0028789361039562,0.0197926857146989,0.0155311026660795,"P2RX1/MYLK/FGF2/CASQ2/CACNA1C/PLN/FGF7/TACR2/CHRM2/PTGFR/PDGFRB/P2RX7/PLCD3/SPHK1/PDE1A/CXCR4/RYR2/PTGER3/HGF/BDKRB1/NTRK3/CD38/TNNC1/CACNA1I/DRD1",25]
["hsa05417","Lipid and atherosclerosis","23/468","215/8113",0.002986389614655,0.0200306620495153,0.0157178400771316,"POU2F2/CYBB/PIK3CD/OLR1/CD14/NFATC1/NCF1/AKT3/NLRP3/NCF2/MMP3/VCAM1/LY96/ICAM1/IL6/CCL2/CCL3/CCL5/LBP/CYP2C9/CD36/MMP9/CYP1A1",23]
["hsa04650","Natural killer cell mediated cytotoxicity","16/468","131/8113",0.00344598418935719,0.0225629917160292,0.0177049312987024,"PIK3CD/LCP2/ITGB2/NFATC1/FCGR3A/TYROBP/CD48/FCER1G/ITGAL/ICAM1/HCST/PRF1/KLRD1/SH2D1A/FCGR3B/GZMB",16]
["hsa05321","Inflammatory bowel disease","10/468","65/8113",0.00378655156802045,0.0242163181675726,0.0190022783707268,"TGFB3/NFATC1/IL21R/HLA-DQA1/HLA-DMB/IL6/IL12RB1/HLA-DPB1/HLA-DQB1/IL12RB2",10]
["hsa04933","AGE-RAGE signaling pathway in diabetic complications","13/468","100/8113",0.00471774692791608,0.0285740647509777,0.0224217541586619,"CYBB/PIK3CD/TGFB3/NFATC1/AKT3/PLCD3/VCAM1/FN1/ICAM1/IL6/CCL2/COL4A4/F3",13]
["hsa05221","Acute myeloid leukemia","10/468","67/8113",0.00473338140300693,0.0285740647509777,0.0224217541586619,"CSF1R/SPI1/RUNX1T1/PIK3CD/CD14/ITGAM/FCGR1A/AKT3/BCL2A1/CCNA1",10]
["hsa04668","TNF signaling pathway","14/468","112/8113",0.00490111219696312,0.0285740647509777,0.0224217541586619,"CREB5/PIK3CD/CSF1/AKT3/MMP3/VCAM1/ICAM1/IL6/CXCL10/CCL2/BIRC3/CCL5/CXCL5/MMP9",14]
["hsa05145","Toxoplasmosis","14/468","112/8113",0.00490111219696312,0.0285740647509777,0.0224217541586619,"GNAO1/TGFB3/IL10RA/PIK3R5/AKT3/LY96/PIK3CG/HLA-DQA1/HLA-DMB/LAMA1/CCR5/HLA-DPB1/BIRC3/HLA-DQB1",14]
["hsa04611","Platelet activation","15/468","124/8113",0.00498747312017066,0.0285740647509777,0.0224217541586619,"P2RX1/MYLK/RASGRP2/FERMT3/PRKG1/BTK/PIK3CD/LCP2/PTGS1/FCGR2A/PIK3R5/ITGB3/FCER1G/AKT3/PIK3CG",15]
["hsa05135","Yersinia infection","16/468","137/8113",0.00536590644548098,0.0301147810715769,0.0236307373001848,"ITGA5/WAS/WIPF1/PIK3CD/LCP2/FCGR2A/NFATC1/AKT3/NLRP3/CD4/ITGA4/FN1/MEFV/IL6/CCL2/CD8A",16]
["hsa04658","Th1 and Th2 cell differentiation","12/468","92/8113",0.00633694366766712,0.0348531901721691,0.0273489147762476,"NFATC1/IL2RA/CD4/RUNX3/HLA-DQA1/HLA-DMB/IL2RB/CD3E/IL12RB1/HLA-DPB1/HLA-DQB1/IL12RB2",12]
["hsa05205","Proteoglycans in cancer","21/468","205/8113",0.00730390558302463,0.0393838046143485,0.0309040380705893,"FLNC/ITGA5/FGF2/PPP1R12B/FLNA/PIK3CD/ANK2/HPSE2/ITGB3/AKT3/DCN/CAV1/THBS1/SHH/FN1/HGF/IHH/GPC3/IGF1/VTN/MMP9",21]
["hsa04666","Fc gamma R-mediated phagocytosis","12/468","97/8113",0.00960688711075581,0.050805652989574,0.0398666367956466,"CFL2/WAS/PIK3CD/BIN1/FCGR2A/FCGR3A/NCF1/FCGR1A/AKT3/SPHK1/FCGR2B/FCGR3B",12]
["hsa04270","Vascular smooth muscle contraction","15/468","134/8113",0.0101047470536116,0.0524302913159092,0.0411414726115269,"MYLK/KCNMB1/CALD1/CACNA1C/ACTG2/RAMP1/MYH11/MYL9/PRKG1/PPP1R12B/KCNMA1/ACTA2/NPR1/PLA2G5/PLA2G2D",15]
["hsa05320","Autoimmune thyroid disease","8/468","53/8113",0.0103421678580499,0.0526684474252543,0.0413283510896732,"CD28/HLA-DQA1/HLA-DMB/CD86/PRF1/HLA-DPB1/HLA-DQB1/GZMB",8]
["hsa00980","Metabolism of xenobiotics by cytochrome P450","10/468","78/8113",0.0136806720895863,0.0684033604479316,0.0536753641792382,"UGT1A1/ADH1B/CYP2C9/UGT2B15/ADH6/CYP1A1/CYP1A2/ADH1C/UGT1A10/GSTM1",10]
["hsa05142","Chagas disease","12/468","102/8113",0.0140582907052116,0.0688217999592365,0.0540037090589224,"GNAO1/C1QC/C1QB/C1QA/PIK3CD/TGFB3/AKT3/IL6/CD3E/CCL2/CCL3/CCL5",12]
["hsa04923","Regulation of lipolysis in adipocytes","8/468","56/8113",0.014264882173369,0.0688217999592365,0.0540037090589224,"PRKG1/PIK3CD/PTGS1/NPR1/AKT3/PTGER3/PLIN1/FABP4",8]
["hsa05166","Human T-cell leukemia virus 1 infection","21/468","222/8113",0.0171140063199144,0.0811439954823527,0.0636728002828031,"CREB5/SPI1/PIK3CD/TGFB3/ITGB2/NFATC1/IL2RA/AKT3/CD4/ITGAL/HLA-DQA1/HLA-DMB/ICAM1/IL6/IL2RB/CD3E/CCND2/HLA-DPB1/HLA-DQB1/MMP7/CCNA1",21]
["hsa05169","Epstein-Barr virus infection","19/468","202/8113",0.0238532374528857,0.111180344060061,0.0872419924681815,"VIM/BTK/PIK3CD/FCER2/AKT3/ITGAL/CR2/RUNX3/HLA-DQA1/HLA-DMB/ICAM1/IL6/CXCL10/CD19/CD3E/CCND2/HLA-DPB1/HLA-DQB1/CCNA1",19]
["hsa03320","PPAR signaling pathway","9/468","75/8113",0.0278283356935063,0.127546538595237,0.100084365213487,"SORBS1/OLR1/LPL/ADIPOQ/PLIN1/CD36/FABP6/HMGCS2/FABP4",9]
["hsa05310","Asthma","5/468","31/8113",0.0306500447751443,0.138176431363355,0.108425525088949,"FCER1G/HLA-DQA1/HLA-DMB/HLA-DPB1/HLA-DQB1",5]
["hsa04022","cGMP-PKG signaling pathway","16/468","167/8113",0.0312272959512787,0.138508167525833,0.10868583480496,"MYLK/KCNMB1/CACNA1C/MYL9/PRKG1/PLN/CREB5/KCNMA1/NFATC1/ATP1A2/PIK3R5/NPR1/RGS2/AKT3/PIK3CG/ADRA2A",16]
["hsa04936","Alcoholic liver disease","14/468","142/8113",0.034229568490781,0.149414783094679,0.117244136016877,"C1QC/C1QB/C1QA/CD14/C3AR1/AKT3/C5AR1/LY96/IL6/ADH1B/LBP/ADIPOQ/ADH6/ADH1C",14]
["hsa04660","T cell receptor signaling pathway","11/468","104/8113",0.0367743546572289,0.157912651442489,0.123912319792192,"PIK3CD/LCP2/NFATC1/AKT3/CD4/CD28/ITK/CD3E/PDCD1/ICOS/CD8A",11]
["hsa01521","EGFR tyrosine kinase inhibitor resistance","9/468","79/8113",0.03732480852277,0.157912651442489,0.123912319792192,"FGF2/AXL/PIK3CD/PDGFRB/AKT3/IL6/HGF/IGF1/NRG1",9]
["hsa04614","Renin-angiotensin system","4/468","23/8113",0.0404326926868052,0.168469552861688,0.132196204159411,"ANPEP/CTSG/CPA3/REN",4]
["hsa04350","TGF-beta signaling pathway","10/468","94/8113",0.0437025853337978,0.176738396570506,0.138684674820875,"SMAD6/FBN1/TGFB3/CHRD/DCN/THBS1/FMOD/GREM1/RGMA/NOG",10]
["hsa04657","IL-17 signaling pathway","10/468","94/8113",0.0437025853337978,0.176738396570506,0.138684674820875,"MMP3/IL6/CXCL10/CCL2/CSF3/CXCL5/MMP9/S100A7/MUC5B/S100A7A",10]
["hsa00534","Glycosaminoglycan biosynthesis - heparan sulfate / heparin","4/468","24/8113",0.0463865805383248,0.184874052870135,0.145068634788049,"HS3ST3B1/HS3ST3A1/HS6ST3/HS3ST5",4]
["hsa04930","Type II diabetes mellitus","6/468","46/8113",0.0472194952407556,0.185505159874397,0.145563857509096,"SLC2A4/CACNA1C/PIK3CD/HK3/ADIPOQ/HKDC1",6]
["hsa04261","Adrenergic signaling in cardiomyocytes","14/468","150/8113",0.0505841055812069,0.195924352603266,0.153739683382467,"CACNA1C/TPM1/PLN/SCN1B/CREB5/ACTC1/TPM2/ATP1A2/PIK3R5/AKT3/PIK3CG/RYR2/SCN7A/TNNC1",14]
["hsa04024","cAMP signaling pathway","19/468","221/8113",0.0523081603513218,0.199788112452965,0.156771533216681,"CACNA1C/MYL9/PLN/CREB5/SSTR2/PIK3CD/PDE4B/NFATC1/ATP1A2/CHRM2/NPR1/AKT3/RYR2/PTGER3/PDE4C/PPP1R1B/DRD1/CRH/SST",19]
["hsa00350","Tyrosine metabolism","5/468","36/8113",0.0538687179698644,0.20293010194127,0.159237017791236,"AOX1/AOC2/ADH1B/ADH6/ADH1C",5]
["hsa04015","Rap1 signaling pathway","18/468","210/8113",0.0591882297533839,0.219956259218657,0.172597256037606,"GNAO1/FGF2/RASGRP2/CSF1R/FGF7/PIK3CD/LCP2/ITGB2/ITGAM/FPR1/CSF1/PDGFRB/ITGB3/AKT3/ITGAL/THBS1/HGF/IGF1",18]
["hsa05164","Influenza A","15/468","171/8113",0.0684468957880768,0.249400558689296,0.195701873804041,"PIK3CD/AKT3/NLRP3/HLA-DQA1/HLA-DMB/ICAM1/IL6/CXCL10/HLA-DPB1/CCL2/CCL5/HLA-DQB1/TMPRSS4/TPSD1/TMPRSS11D",15]
["hsa05146","Amoebiasis","10/468","102/8113",0.0689252453104965,0.249400558689296,0.195701873804041,"PIK3CD/TGFB3/CD14/ITGB2/ITGAM/CTSG/FN1/IL6/LAMA1/COL4A4",10]
["hsa05171","Coronavirus disease - COVID-19","19/468","232/8113",0.07694572852013,0.274806173286179,0.215637379994896,"F13A1/C1QC/CYBB/C1QB/C1QA/PIK3CD/C1R/FCGR2A/C3AR1/C1S/NLRP3/TLR8/C5AR1/MMP3/IL6/CXCL10/C7/CCL2/CSF3",19]
["hsa00591","Linoleic acid metabolism","4/468","29/8113",0.0829525168523057,0.292460796594668,0.229490768619739,"PLA2G5/CYP2C9/PLA2G2D/CYP1A2",4]
["hsa05163","Human cytomegalovirus infection","18/468","225/8113",0.0987911319102422,0.337301121451573,0.264676478076833,"GNAO1/CREB5/CXCL12/GNG2/PIK3CD/IL10RA/NFATC1/ITGB3/AKT3/CXCR4/IL6/PTGER3/CCR1/CCR5/CCL4/CCL2/CCL3/CCL5",18]
["hsa05165","Human papillomavirus infection","25/468","331/8113",0.0997436432345748,0.337301121451573,0.264676478076833,"ITGA7/ITGA5/COL6A1/COL6A2/CREB5/PIK3CD/MFNG/THBS4/PDGFRB/ITGB3/COL6A3/AKT3/TNC/ITGA4/THBS1/FN1/LAMA1/ITGA11/CCND2/COL4A4/COMP/COL9A1/VTN/COL2A1/CCNA1",25]
["hsa05204","Chemical carcinogenesis - DNA adducts","7/468","69/8113",0.101482686068789,0.337301121451573,0.264676478076833,"UGT1A1/CYP2C9/UGT2B15/CYP1A1/CYP1A2/UGT1A10/GSTM1",7]
["hsa04310","Wnt signaling pathway","14/468","167/8113",0.101542511938749,0.337301121451573,0.264676478076833,"RSPO3/NFATC1/ROR2/SFRP1/PRICKLE1/CCND2/SERPINF1/ROR1/SFRP2/SFRP4/DKK4/CTNND2/MMP7/WIF1",14]
["hsa04340","Hedgehog signaling pathway","6/468","56/8113",0.102013796385427,0.337301121451573,0.264676478076833,"BOC/GLI2/GAS1/SHH/IHH/CCND2",6]
["hsa04360","Axon guidance","15/468","182/8113",0.103030160734299,0.337301121451573,0.264676478076833,"CFL2/BOC/MYL9/PLXNC1/DPYSL2/CXCL12/PIK3CD/NTN1/EPHB6/SLIT2/CXCR4/SHH/SEMA6A/PLXNA4/RGMA",15]
["hsa05134","Legionellosis","6/468","57/8113",0.108797941072237,0.35199333876312,0.276205299316515,"CR1/CD14/ITGB2/ITGAM/IL6/EEF1A2",6]
["hsa04725","Cholinergic synapse","10/468","113/8113",0.116258094905598,0.367108538089868,0.288066029888701,"GNAO1/CACNA1C/CREB5/GNG2/PIK3CD/CHRM2/PIK3R5/AKT3/PIK3CG/KCNQ5",10]
["hsa04080","Neuroactive ligand-receptor interaction","26/468","353/8113",0.117351448319858,0.367108538089868,0.288066029888701,"P2RX1/SSTR2/TACR2/C3AR1/CHRM2/FPR1/PTGFR/GLP2R/P2RX7/CTSG/GRIK5/C5AR1/P2RY14/NTS/GRM3/GZMA/PTGER3/ADRA2A/FPR3/F2RL2/BDKRB1/FPR2/GABRP/DRD1/CRH/SST",26]
["hsa00770","Pantothenate and CoA biosynthesis","3/468","21/8113",0.117474732188758,0.367108538089868,0.288066029888701,"VNN1/ENPP1/VNN2",3]
["hsa05218","Melanoma","7/468","72/8113",0.120090682639412,0.371066716020656,0.291171968552094,"FGF2/FGF7/PIK3CD/PDGFRB/AKT3/HGF/IGF1",7]
["hsa04260","Cardiac muscle contraction","8/468","87/8113",0.127904818057646,0.390820277398363,0.306672370781491,"CASQ2/CACNA1C/TPM1/ACTC1/TPM2/ATP1A2/RYR2/TNNC1",8]
["hsa04973","Carbohydrate digestion and absorption","5/468","47/8113",0.132341217729182,0.398575366709317,0.312757704020708,"PIK3CD/ATP1A2/AKT3/HK3/HKDC1",5]
["hsa04972","Pancreatic secretion","9/468","102/8113",0.13334157722639,0.398575366709317,0.312757704020708,"KCNMA1/ATP1A2/PLA2G5/CPA3/RYR2/CD38/PLA2G2D/CLCA4/CPB1",9]
["hsa00140","Steroid hormone biosynthesis","6/468","61/8113",0.138145549381136,0.404149213615024,0.317131440348632,"UGT1A1/HSD17B2/UGT2B15/CYP1A1/CYP1A2/UGT1A10",6]
["hsa00590","Arachidonic acid metabolism","6/468","61/8113",0.138145549381136,0.404149213615024,0.317131440348632,"PTGS1/PTGDS/PLA2G5/PTGIS/CYP2C9/PLA2G2D",6]
["hsa00760","Nicotinate and nicotinamide metabolism","4/468","35/8113",0.140466353839438,0.406613129535214,0.31906484805634,"AOX1/ENPP1/NNMT/CD38",4]
["hsa04625","C-type lectin receptor signaling pathway","9/468","104/8113",0.14509825392517,0.415646039889811,0.326152873406359,"CD209/PIK3CD/NFATC1/FCER1G/AKT3/NLRP3/EGR3/IL6/CLEC4E",9]
["hsa00500","Starch and sucrose metabolism","4/468","36/8113",0.151291058323134,0.428917948854247,0.336567194316251,"PYGM/ENPP1/HK3/HKDC1",4]
["hsa04612","Antigen processing and presentation","7/468","78/8113",0.162096212874883,0.451170687988218,0.354028673828075,"CD4/HLA-DQA1/HLA-DMB/HLA-DPB1/KLRD1/HLA-DQB1/CD8A",7]
["hsa05143","African trypanosomiasis","4/468","37/8113",0.162421447675758,0.451170687988218,0.354028673828075,"VCAM1/ICAM1/IL6/IDO1",4]
["hsa04915","Estrogen signaling pathway","11/468","138/8113",0.17239447968616,0.474084819136939,0.372009140375397,"GNAO1/CREB5/PIK3CD/FKBP5/AKT3/TFF1/MMP9/KRT13/KRT24/KRT14/KRT31",11]
["hsa04921","Oxytocin signaling pathway","12/468","154/8113",0.177826751946372,0.475762943181141,0.373325945845489,"GNAO1/MYLK/CACNA1C/MYL9/PPP1R12B/NFATC1/PIK3R5/NPR1/RGS2/PIK3CG/RYR2/CD38",12]
["hsa05162","Measles","11/468","139/8113",0.178194847809664,0.475762943181141,0.373325945845489,"CD209/PIK3CD/IL2RA/AKT3/CD28/IL6/IL2RB/SLAMF1/CD3E/CCND2/FCGR2B",11]
["hsa05418","Fluid shear stress and atherosclerosis","11/468","139/8113",0.178194847809664,0.475762943181141,0.373325945845489,"PIK3CD/NCF1/ITGB3/AKT3/NCF2/CAV1/VCAM1/ICAM1/CCL2/MMP9/GSTM1",11]
["hsa04010","MAPK signaling pathway","21/468","294/8113",0.181472853411459,0.479856102770684,0.376537803131063,"FLNC/FGF2/RASGRP2/CSF1R/CACNA1C/RASGRP4/FGF7/FLNA/TGFB3/CD14/NFATC1/CSF1/PDGFRB/AKT3/MAP4K1/PTPN7/HGF/IGF1/DUSP2/PTPRR/CACNA1I",21]
["hsa00010","Glycolysis / Gluconeogenesis","6/468","67/8113",0.188177520656515,0.492845887433729,0.386730744206371,"HK3/FBP1/ADH1B/ADH6/HKDC1/ADH1C",6]
["hsa05215","Prostate cancer","8/468","97/8113",0.195935616317885,0.50664584248262,0.397559417067702,"ZEB1/CREB5/PIK3CD/PDGFRB/AKT3/MMP3/IGF1/MMP9",8]
["hsa04664","Fc epsilon RI signaling pathway","6/468","68/8113",0.197131291438692,0.50664584248262,0.397559417067702,"BTK/PIK3CD/LCP2/FCER1G/AKT3/ALOX5AP",6]
["hsa04924","Renin secretion","6/468","69/8113",0.206240682426302,0.525149885807714,0.41207933623189,"CACNA1C/KCNMA1/NPR1/PDE1A/REN/CLCA4",6]
["hsa05230","Central carbon metabolism in cancer","6/468","70/8113",0.215497680597097,0.543686808845887,0.426625055745098,"PIK3CD/PDGFRB/AKT3/HK3/NTRK3/HKDC1",6]
["hsa00380","Tryptophan metabolism","4/468","42/8113",0.221966016755662,0.554915041889155,0.435435726649863,"AOX1/IDO1/CYP1A1/CYP1A2",4]
["hsa04911","Insulin secretion","7/468","86/8113",0.226674251096759,0.561580351816295,0.440665921999389,"KCNMB1/CACNA1C/CREB5/KCNMA1/ATP1A2/RYR2/SNAP25",7]
["hsa04072","Phospholipase D signaling pathway","11/468","148/8113",0.234267123115281,0.570716095509776,0.447834639538771,"CYTH4/PIK3CD/PIK3R5/PTGFR/PDGFRB/FCER1G/AKT3/SPHK1/GRM3/DGKI/PIK3CG",11]
["hsa04975","Fat digestion and absorption","4/468","43/8113",0.234512431973108,0.570716095509776,0.447834639538771,"PLA2G5/MOGAT2/PLA2G2D/CD36",4]
["hsa05130","Pathogenic Escherichia coli infection","14/468","197/8113",0.246506465183404,0.594124857389792,0.466203237377636,"NCKAP1L/CYTH4/MYH11/WIPF1/MYO1F/MYO1G/FCGR2A/NLRP3/IL6/TUBA3C/CLDN9/CLDN18/CLDN3/CLDN6",14]
["hsa00053","Ascorbate and aldarate metabolism","3/468","30/8113",0.248452213090277,0.594124857389792,0.466203237377636,"UGT1A1/UGT2B15/UGT1A10",3]
["hsa05235","PD-L1 expression and PD-1 checkpoint pathway in cancer","7/468","89/8113",0.252916038578385,0.599585436284965,0.470488093544183,"PIK3CD/NFATC1/AKT3/CD4/CD28/CD3E/PDCD1",7]
["hsa04152","AMPK signaling pathway","9/468","120/8113",0.255483589390887,0.600495616089692,0.47120230162062,"SLC2A4/CREB5/PIK3CD/AKT3/FBP1/IGF1/ADIPOQ/CD36/CCNA1",9]
["hsa04014","Ras signaling pathway","16/468","232/8113",0.264320599287717,0.616001396645103,0.483369516984674,"FGF2/RASGRP2/CSF1R/RASGRP4/FGF7/GNG2/PIK3CD/RASA3/CSF1/PDGFRB/AKT3/RASAL3/PLA2G5/HGF/IGF1/PLA2G2D",16]
["hsa05032","Morphine addiction","7/468","91/8113",0.270893642036092,0.62601471899097,0.491226860835019,"GNAO1/GNG2/PDE4B/PDE1A/PDE4C/GABRP/DRD1",7]
["hsa04931","Insulin resistance","8/468","108/8113",0.284084417045663,0.651026789062978,0.510853556968079,"GFPT2/SLC2A4/CREB5/PYGM/PIK3CD/AKT3/IL6/CD36",8]
["hsa04970","Salivary secretion","7/468","93/8113",0.289198745456103,0.657269876036598,0.51575243861245,"PRKG1/KCNMA1/ATP1A2/LYZ/CD38/CST4/MUC5B",7]
["hsa00051","Fructose and mannose metabolism","3/468","33/8113",0.296298584828773,0.667886154327151,0.524082915357191,"HK3/FBP1/HKDC1",3]
["hsa00040","Pentose and glucuronate interconversions","3/468","34/8113",0.312395251548663,0.6876841391152,0.539618176147813,"UGT1A1/UGT2B15/UGT1A10",3]
["hsa00520","Amino sugar and nucleotide sugar metabolism","4/468","49/8113",0.312583699597818,0.6876841391152,0.539618176147813,"GFPT2/HK3/CHIT1/HKDC1",4]
["hsa05030","Cocaine addiction","4/468","49/8113",0.312583699597818,0.6876841391152,0.539618176147813,"CREB5/GRM3/PPP1R1B/DRD1",4]
["hsa00670","One carbon pool by folate","2/468","20/8113",0.32221657884918,0.703250469710513,0.551832904461838,"ALDH1L2/ALDH1L1",2]
["hsa05167","Kaposi sarcoma-associated herpesvirus infection","13/468","194/8113",0.328412789473535,0.71113005594663,0.558015929068169,"FGF2/GNG2/PIK3CD/NFATC1/PIK3R5/AKT3/PIK3CG/ICAM1/IL6/CD86/CCR1/CCR5/CCR4",13]
["hsa04068","FoxO signaling pathway","9/468","131/8113",0.343374605425032,0.737718878842841,0.578879885790555,"SLC2A4/PIK3CD/TGFB3/FBXO32/IL7R/AKT3/IL6/CCND2/IGF1",9]
["hsa01250","Biosynthesis of nucleotide sugars","3/468","37/8113",0.360701484287425,0.763022370608015,0.598735257319208,"GFPT2/HK3/HKDC1",3]
["hsa04960","Aldosterone-regulated sodium reabsorption","3/468","37/8113",0.360701484287425,0.763022370608015,0.598735257319208,"PIK3CD/ATP1A2/IGF1",3]
["hsa05415","Diabetic cardiomyopathy","13/468","203/8113",0.389361993001816,0.817362962408391,0.641375721698451,"GFPT2/SLC2A4/PLN/CYBB/PIK3CD/TGFB3/NCF1/AKT3/NCF2/RYR2/REN/CD36/MMP9",13]
["hsa04919","Thyroid hormone signaling pathway","8/468","121/8113",0.398065734137964,0.829303612787424,0.650745418646591,"PLN/PIK3CD/ATP1A2/ITGB3/SLC16A2/AKT3/PLCD3/DIO3",8]
["hsa05020","Prion disease","17/468","273/8113",0.407721607816326,0.841381908174296,0.66022312411763,"NCAM1/CACNA1C/C1QC/CYBB/CREB5/C1QB/C1QA/PIK3CD/NCF1/NCF2/CAV1/IL6/RYR2/C7/CCL5/NCAM2/TUBA3C",17]
["hsa04371","Apelin signaling pathway","9/468","139/8113",0.409982457074021,0.841381908174296,0.66022312411763,"MYLK/GNG2/ACTA2/PIK3R5/AKT3/SPHK1/PIK3CG/RYR2/PLIN1",9]
["hsa00592","alpha-Linolenic acid metabolism","2/468","25/8113",0.427292526452302,0.870410702032468,0.683001699202511,"PLA2G5/PLA2G2D",2]
["hsa04918","Thyroid hormone synthesis","5/468","75/8113",0.436750373214805,0.879593824265116,0.690207594160187,"CREB5/ATP1A2/IYD/DUOXA2/DUOX2",5]
["hsa05222","Small cell lung cancer","6/468","92/8113",0.4395656274628,0.879593824265116,0.690207594160187,"PIK3CD/AKT3/FN1/LAMA1/COL4A4/BIRC3",6]
["hsa04066","HIF-1 signaling pathway","7/468","109/8113",0.441396173631222,0.879593824265116,0.690207594160187,"CYBB/PIK3CD/AKT3/HK3/IL6/IGF1/HKDC1",7]
["hsa00071","Fatty acid degradation","3/468","43/8113",0.455125629187482,0.887445707475127,0.696368880506798,"ADH1B/ADH6/ADH1C",3]
["hsa00860","Porphyrin metabolism","3/468","43/8113",0.455125629187482,0.887445707475127,0.696368880506798,"UGT1A1/UGT2B15/UGT1A10",3]
["hsa04730","Long-term depression","4/468","60/8113",0.458244692587156,0.887445707475127,0.696368880506798,"GNAO1/PRKG1/IGF1/CRH",4]
["hsa04978","Mineral absorption","4/468","60/8113",0.458244692587156,0.887445707475127,0.696368880506798,"ATP1A2/CYBRD1/MT1M/MT2A",4]
["hsa04926","Relaxin signaling pathway","8/468","129/8113",0.46914008600092,0.896965293927684,0.70383879523512,"GNAO1/CREB5/GNG2/PIK3CD/ACTA2/AKT3/COL4A4/MMP9",8]
["hsa05132","Salmonella infection","15/468","249/8113",0.469683644820314,0.896965293927684,0.70383879523512,"FLNC/NCKAP1L/CYTH4/MYL9/FLNA/PIK3CD/CD14/RHOH/AKT3/NLRP3/LY96/PIK3CG/IL6/BIRC3/TUBA3C",15]
["hsa04213","Longevity regulating pathway - multiple species","4/468","62/8113",0.483862496238952,0.906478963686086,0.711304067198651,"PIK3CD/AKT3/CRYAB/IGF1",4]
["hsa02010","ABC transporters","3/468","45/8113",0.485356203546696,0.906478963686086,0.711304067198651,"ABCC9/ABCA10/ABCA4",3]
["hsa04713","Circadian entrainment","6/468","97/8113",0.490935057740158,0.906478963686086,0.711304067198651,"GNAO1/CACNA1C/PRKG1/GNG2/RYR2/CACNA1I",6]
["hsa00983","Drug metabolism - other enzymes","5/468","80/8113",0.493490300455944,0.906478963686086,0.711304067198651,"UGT1A1/CDA/UGT2B15/UGT1A10/GSTM1",5]
["hsa04621","NOD-like receptor signaling pathway","11/468","184/8113",0.496368554757405,0.906478963686086,0.711304067198651,"CYBB/P2RX7/NLRP3/TRPV2/MEFV/IL6/CCL2/GBP5/BIRC3/CCL5/NLRP7",11]
["hsa04623","Cytosolic DNA-sensing pathway","4/468","63/8113",0.496490369371879,0.906478963686086,0.711304067198651,"IL6/CXCL10/CCL4/CCL5",4]
["hsa04925","Aldosterone synthesis and secretion","6/468","98/8113",0.501035645382855,0.906478963686086,0.711304067198651,"CACNA1C/CREB5/ATP1A2/NPR1/KCNK3/CACNA1I",6]
["hsa05231","Choline metabolism in cancer","6/468","98/8113",0.501035645382855,0.906478963686086,0.711304067198651,"WAS/PIK3CD/SLC44A3/PDGFRB/AKT3/DGKI",6]
["hsa04929","GnRH secretion","4/468","64/8113",0.508985375317929,0.914842994852487,0.717867230410564,"CACNA1C/PIK3CD/AKT3/CACNA1I",4]
["hsa00620","Pyruvate metabolism","3/468","47/8113",0.514758826029189,0.919212189337838,0.721295689241175,"ADH1B/ADH6/ADH1C",3]
["hsa04927","Cortisol synthesis and secretion","4/468","65/8113",0.521339166719469,0.922372669868313,0.72377568353303,"CACNA1C/CREB5/KCNK3/CACNA1I",4]
["hsa00030","Pentose phosphate pathway","2/468","30/8113",0.523236859998025,0.922372669868313,0.72377568353303,"FBP1/TKTL1",2]
["hsa04210","Apoptosis","8/468","136/8113",0.529782478138586,0.924230563010267,0.725233551835807,"PIK3CD/AKT3/CTSK/BCL2A1/PRF1/BIRC3/GZMB/TUBA3C",8]
["hsa04935","Growth hormone synthesis, secretion and action","7/468","119/8113",0.534756878227103,0.924230563010267,0.725233551835807,"CACNA1C/CREB5/SSTR2/PIK3CD/AKT3/IGF1/SST",7]
["hsa04910","Insulin signaling pathway","8/468","137/8113",0.538249351845123,0.924230563010267,0.725233551835807,"SORBS1/SLC2A4/PYGM/PIK3CD/AKT3/HK3/FBP1/HKDC1",8]
["hsa00052","Galactose metabolism","2/468","31/8113",0.541094984162374,0.924230563010267,0.725233551835807,"HK3/HKDC1",2]
["hsa01523","Antifolate resistance","2/468","31/8113",0.541094984162374,0.924230563010267,0.725233551835807,"FOLR2/IL6",2]
["hsa04979","Cholesterol metabolism","3/468","50/8113",0.557116286385312,0.939832795367365,0.737476451867214,"LPL/CD36/PCSK9",3]
["hsa04920","Adipocytokine signaling pathway","4/468","69/8113",0.569196498885608,0.939832795367365,0.737476451867214,"SLC2A4/AKT3/ADIPOQ/CD36",4]
["hsa05031","Amphetamine addiction","4/468","69/8113",0.569196498885608,0.939832795367365,0.737476451867214,"CACNA1C/CREB5/PPP1R1B/DRD1",4]
["hsa05211","Renal cell carcinoma","4/468","69/8113",0.569196498885608,0.939832795367365,0.737476451867214,"PIK3CD/TGFB3/AKT3/HGF",4]
["hsa05207","Chemical carcinogenesis - receptor activation","12/468","212/8113",0.570260892834691,0.939832795367365,0.737476451867214,"FGF2/CACNA1C/CREB5/FGF7/PIK3CD/AKT3/UGT1A1/UGT2B15/CYP1A1/CYP1A2/UGT1A10/GSTM1",12]
["hsa04913","Ovarian steroidogenesis","3/468","51/8113",0.570734824823091,0.939832795367365,0.737476451867214,"HSD17B2/IGF1/CYP1A1",3]
["hsa04928","Parathyroid hormone synthesis, secretion and action","6/468","106/8113",0.578912964630872,0.947625388532677,0.743591213968225,"CREB5/MAFB/PDE4B/MMP25/PDE4C/PTHLH",6]
["hsa04211","Longevity regulating pathway","5/468","89/8113",0.589501812810978,0.959248511970527,0.752711751019935,"CREB5/PIK3CD/AKT3/IGF1/ADIPOQ",5]
["hsa05161","Hepatitis B","9/468","162/8113",0.595607999360355,0.963483528377044,0.756034921788685,"CREB5/PIK3CD/TGFB3/NFATC1/AKT3/EGR3/IL6/MMP9/CCNA1",9]
["hsa01524","Platinum drug resistance","4/468","73/8113",0.614280425764921,0.987877877692124,0.775176899241667,"PIK3CD/AKT3/BIRC3/GSTM1",4]
["hsa05226","Gastric cancer","8/468","149/8113",0.634524498411527,0.999999999145607,0.784688994544878,"FGF2/FGF7/PIK3CD/TGFB3/AKT3/SHH/HGF/REG4",8]
["hsa05214","Glioma","4/468","75/8113",0.635694570206,0.999999999145607,0.784688994544878,"PIK3CD/PDGFRB/AKT3/IGF1",4]
["hsa00360","Phenylalanine metabolism","1/468","17/8113",0.63618052422974,0.999999999145607,0.784688994544878,"AOC2",1]
["hsa04728","Dopaminergic synapse","7/468","132/8113",0.64549171106428,0.999999999145607,0.784688994544878,"GNAO1/CACNA1C/CREB5/GNG2/AKT3/PPP1R1B/DRD1",7]
["hsa04971","Gastric acid secretion","4/468","76/8113",0.64610901373819,0.999999999145607,0.784688994544878,"MYLK/SSTR2/ATP1A2/SST",4]
["hsa04530","Tight junction","9/468","169/8113",0.646522238508977,0.999999999145607,0.784688994544878,"MYH11/JAM3/MYL9/WAS/TUBA3C/CLDN9/CLDN18/CLDN3/CLDN6",9]
["hsa05100","Bacterial invasion of epithelial cells","4/468","77/8113",0.656325482000668,0.999999999145607,0.784688994544878,"ITGA5/PIK3CD/CAV1/FN1",4]
["hsa04370","VEGF signaling pathway","3/468","59/8113",0.669921476665286,0.999999999145607,0.784688994544878,"PIK3CD/AKT3/SPHK1",3]
["hsa00531","Glycosaminoglycan degradation","1/468","19/8113",0.677029376498603,0.999999999145607,0.784688994544878,"HPSE2",1]
["hsa00260","Glycine, serine and threonine metabolism","2/468","40/8113",0.68047525648963,0.999999999145607,0.784688994544878,"AOC2/BHMT",2]
["hsa00561","Glycerolipid metabolism","3/468","61/8113",0.691921927005467,0.999999999145607,0.784688994544878,"DGKI/LPL/MOGAT2",3]
["hsa05219","Bladder cancer","2/468","41/8113",0.693618646357747,0.999999999145607,0.784688994544878,"THBS1/MMP9",2]
["hsa04914","Progesterone-mediated oocyte maturation","5/468","102/8113",0.708527948025864,0.999999999145607,0.784688994544878,"PIK3CD/CPEB1/AKT3/IGF1/CCNA1",5]
["hsa00340","Histidine metabolism","1/468","22/8113",0.729881739708784,0.999999999145607,0.784688994544878,"HDC",1]
["hsa00900","Terpenoid backbone biosynthesis","1/468","22/8113",0.729881739708784,0.999999999145607,0.784688994544878,"HMGCS2",1]
["hsa04962","Vasopressin-regulated water reabsorption","2/468","44/8113",0.73038629545106,0.999999999145607,0.784688994544878,"CREB5/AQP3",2]
["hsa00230","Purine metabolism","6/468","126/8113",0.742258550821897,0.999999999145607,0.784688994544878,"PDE4B/ENPP1/NPR1/PDE1A/GDA/PDE4C",6]
["hsa04964","Proximal tubule bicarbonate reclamation","1/468","23/8113",0.745505932740089,0.999999999145607,0.784688994544878,"ATP1A2",1]
["hsa04540","Gap junction","4/468","88/8113",0.755415747957688,0.999999999145607,0.784688994544878,"PRKG1/PDGFRB/TUBA3C/DRD1",4]
["hsa04977","Vitamin digestion and absorption","1/468","24/8113",0.760228210055001,0.999999999145607,0.784688994544878,"SLC19A3",1]
["hsa04727","GABAergic synapse","4/468","89/8113",0.763223462552827,0.999999999145607,0.784688994544878,"GNAO1/CACNA1C/GNG2/GABRP",4]
["hsa04976","Bile secretion","4/468","89/8113",0.763223462552827,0.999999999145607,0.784688994544878,"ATP1A2/UGT1A1/UGT2B15/UGT1A10",4]
["hsa00280","Valine, leucine and isoleucine degradation","2/468","48/8113",0.773527281222186,0.999999999145607,0.784688994544878,"AOX1/HMGCS2",2]
["hsa04917","Prolactin signaling pathway","3/468","70/8113",0.777312121462886,0.999999999145607,0.784688994544878,"PIK3CD/AKT3/CCND2",3]
["hsa00565","Ether lipid metabolism","2/468","49/8113",0.783326639189721,0.999999999145607,0.784688994544878,"PLA2G5/PLA2G2D",2]
["hsa00600","Sphingolipid metabolism","2/468","49/8113",0.783326639189721,0.999999999145607,0.784688994544878,"SPHK1/DEGS2",2]
["hsa05170","Human immunodeficiency virus 1 infection","10/468","212/8113",0.788449720387673,0.999999999145607,0.784688994544878,"CFL2/GNAO1/GNG2/PIK3CD/NFATC1/AKT3/CD4/CXCR4/CD3E/CCR5",10]
["hsa00270","Cysteine and methionine metabolism","2/468","50/8113",0.792752070556572,0.999999999145607,0.784688994544878,"BHMT2/BHMT",2]
["hsa05223","Non-small cell lung cancer","3/468","72/8113",0.793404640658182,0.999999999145607,0.784688994544878,"PIK3CD/AKT3/HGF",3]
["hsa04144","Endocytosis","12/468","252/8113",0.794580610386941,0.999999999145607,0.784688994544878,"CHMP4C/PSD/CYTH4/FOLR2/WIPF1/BIN1/ACAP1/IL2RA/CAV1/CXCR4/IL2RB/CCR5",12]
["hsa04724","Glutamatergic synapse","5/468","114/8113",0.794939343359994,0.999999999145607,0.784688994544878,"GNAO1/CACNA1C/GNG2/GRIK5/GRM3",5]
["hsa00601","Glycosphingolipid biosynthesis - lacto and neolacto series","1/468","27/8113",0.799488368456464,0.999999999145607,0.784688994544878,"ST3GAL6",1]
["hsa00562","Inositol phosphate metabolism","3/468","73/8113",0.801081392725035,0.999999999145607,0.784688994544878,"PIK3CD/PLCD3/PIK3CG",3]
["hsa04115","p53 signaling pathway","3/468","73/8113",0.801081392725035,0.999999999145607,0.784688994544878,"THBS1/CCND2/IGF1",3]
["hsa04726","Serotonergic synapse","5/468","115/8113",0.801137226120662,0.999999999145607,0.784688994544878,"GNAO1/CACNA1C/GNG2/PTGS1/CYP2C9",5]
["hsa04218","Cellular senescence","7/468","156/8113",0.80382661115492,0.999999999145607,0.784688994544878,"PIK3CD/TGFB3/NFATC1/AKT3/IL6/CCND2/CCNA1",7]
["hsa05160","Hepatitis C","7/468","157/8113",0.809041191269465,0.999999999145607,0.784688994544878,"PIK3CD/AKT3/CXCL10/CLDN9/CLDN18/CLDN3/CLDN6",7]
["hsa00650","Butanoate metabolism","1/468","28/8113",0.811093543272488,0.999999999145607,0.784688994544878,"HMGCS2",1]
["hsa04392","Hippo signaling pathway - multiple species","1/468","29/8113",0.822028388263023,0.999999999145607,0.784688994544878,"DCHS1",1]
["hsa05212","Pancreatic cancer","3/468","76/8113",0.822689132932905,0.999999999145607,0.784688994544878,"PIK3CD/TGFB3/AKT3",3]
["hsa05220","Chronic myeloid leukemia","3/468","76/8113",0.822689132932905,0.999999999145607,0.784688994544878,"PIK3CD/TGFB3/AKT3",3]
["hsa04071","Sphingolipid signaling pathway","5/468","119/8113",0.824462148511838,0.999999999145607,0.784688994544878,"PIK3CD/FCER1G/AKT3/SPHK1/DEGS2",5]
["hsa01522","Endocrine resistance","4/468","98/8113",0.824986228873705,0.999999999145607,0.784688994544878,"PIK3CD/AKT3/IGF1/MMP9",4]
["hsa04750","Inflammatory mediator regulation of TRP channels","4/468","98/8113",0.824986228873705,0.999999999145607,0.784688994544878,"PIK3CD/TRPV2/IGF1/BDKRB1",4]
["hsa00410","beta-Alanine metabolism","1/468","31/8113",0.842039429751683,0.999999999145607,0.784688994544878,"AOC2",1]
["hsa04215","Apoptosis - multiple species","1/468","32/8113",0.851186367004369,0.999999999145607,0.784688994544878,"BIRC3",1]
["hsa05131","Shigellosis","11/468","247/8113",0.85189670316452,0.999999999145607,0.784688994544878,"ITGA5/CYTH4/MYL9/PIK3CD/CD14/AKT3/NLRP3/PLCD3/HK3/CCL5/HKDC1",11]
["hsa00240","Pyrimidine metabolism","2/468","58/8113",0.85594513480509,0.999999999145607,0.784688994544878,"ENPP1/CDA",2]
["hsa00480","Glutathione metabolism","2/468","58/8113",0.85594513480509,0.999999999145607,0.784688994544878,"ANPEP/GSTM1",2]
["hsa05213","Endometrial cancer","2/468","58/8113",0.85594513480509,0.999999999145607,0.784688994544878,"PIK3CD/AKT3",2]
["hsa05206","MicroRNAs in cancer","14/468","310/8113",0.863787829984519,0.999999999145607,0.784688994544878,"ZEB2/ITGA5/VIM/ZEB1/TPM1/PIK3CD/PDGFRB/ITGB3/TNC/THBS1/CCND2/MMP9/HMGA2/IGF2BP1",14]
["hsa04922","Glucagon signaling pathway","4/468","107/8113",0.872802665538683,0.999999999145607,0.784688994544878,"CREB5/PYGM/AKT3/FBP1",4]
["hsa04012","ErbB signaling pathway","3/468","85/8113",0.875864777708408,0.999999999145607,0.784688994544878,"PIK3CD/AKT3/NRG1",3]
["hsa05210","Colorectal cancer","3/468","86/8113",0.880804148344791,0.999999999145607,0.784688994544878,"PIK3CD/TGFB3/AKT3",3]
["hsa05217","Basal cell carcinoma","2/468","63/8113",0.885958934010542,0.999999999145607,0.784688994544878,"GLI2/SHH",2]
["hsa00250","Alanine, aspartate and glutamate metabolism","1/468","37/8113",0.889576048530991,0.999999999145607,0.784688994544878,"GFPT2",1]
["hsa01200","Carbon metabolism","4/468","115/8113",0.905413017499743,0.999999999145607,0.784688994544878,"HK3/FBP1/HKDC1/TKTL1",4]
["hsa05033","Nicotine addiction","1/468","40/8113",0.907684220954954,0.999999999145607,0.784688994544878,"GABRP",1]
["hsa05203","Viral carcinogenesis","8/468","204/8113",0.909350963575889,0.999999999145607,0.784688994544878,"CREB5/PIK3CD/EGR3/CCR5/CCND2/HDAC9/CCR4/CCNA1",8]
["hsa04216","Ferroptosis","1/468","41/8113",0.913035860319884,0.999999999145607,0.784688994544878,"CYBB",1]
["hsa05120","Epithelial cell signaling in Helicobacter pylori infection","2/468","70/8113",0.91833930408094,0.999999999145607,0.784688994544878,"JAM3/CCL5",2]
["hsa05034","Alcoholism","7/468","187/8113",0.920925563617269,0.999999999145607,0.784688994544878,"GNAO1/CREB5/GNG2/HDAC9/PPP1R1B/DRD1/CRH",7]
["hsa04520","Adherens junction","2/468","71/8113",0.9221902103968,0.999999999145607,0.784688994544878,"SORBS1/WAS",2]
["hsa04070","Phosphatidylinositol signaling system","3/468","97/8113",0.924618457892355,0.999999999145607,0.784688994544878,"PIK3CD/PLCD3/DGKI",3]
["hsa00564","Glycerophospholipid metabolism","3/468","98/8113",0.927764738808734,0.999999999145607,0.784688994544878,"PLA2G5/DGKI/PLA2G2D",3]
["hsa05224","Breast cancer","5/468","147/8113",0.932292291047955,0.999999999145607,0.784688994544878,"FGF2/FGF7/PIK3CD/AKT3/IGF1",5]
["hsa00514","Other types of O-glycan biosynthesis","1/468","47/8113",0.939234616803212,0.999999999145607,0.784688994544878,"MFNG",1]
["hsa05208","Chemical carcinogenesis - reactive oxygen species","8/468","223/8113",0.949390327311619,0.999999999145607,0.784688994544878,"PIK3CD/NCF1/AKT3/NCF2/HGF/CYP1A1/CYP1A2/GSTM1",8]
["hsa04934","Cushing syndrome","5/468","155/8113",0.949554051839497,0.999999999145607,0.784688994544878,"CACNA1C/CREB5/KCNK3/CACNA1I/CRH",5]
["hsa04142","Lysosome","4/468","132/8113",0.951275855479719,0.999999999145607,0.784688994544878,"CTSE/CTSG/CTSK/LAPTM5",4]
["hsa00330","Arginine and proline metabolism","1/468","51/8113",0.952158958842276,0.999999999145607,0.784688994544878,"P4HA3",1]
["hsa04390","Hippo signaling pathway","5/468","157/8113",0.953195317824628,0.999999999145607,0.784688994544878,"TGFB3/ITGB2/GLI2/CCND2/BIRC3",5]
["hsa04217","Necroptosis","5/468","159/8113",0.956596207331794,0.999999999145607,0.784688994544878,"CHMP4C/CYBB/PYGM/NLRP3/BIRC3",5]
["hsa04961","Endocrine and other factor-regulated calcium reabsorption","1/468","53/8113",0.957552423442803,0.999999999145607,0.784688994544878,"ATP1A2",1]
["hsa04742","Taste transduction","2/468","86/8113",0.962866042497159,0.999999999145607,0.784688994544878,"CACNA1C/PDE1A",2]
["hsa04550","Signaling pathways regulating pluripotency of stem cells","4/468","143/8113",0.968945930621135,0.999999999145607,0.784688994544878,"FGF2/PIK3CD/AKT3/IGF1",4]
["hsa05225","Hepatocellular carcinoma","5/468","168/8113",0.969279221489984,0.999999999145607,0.784688994544878,"PIK3CD/TGFB3/AKT3/HGF/GSTM1",5]
["hsa04330","Notch signaling pathway","1/468","59/8113",0.970356464493503,0.999999999145607,0.784688994544878,"MFNG",1]
["hsa04722","Neurotrophin signaling pathway","3/468","119/8113",0.971419864242751,0.999999999145607,0.784688994544878,"PIK3CD/AKT3/NTRK3",3]
["hsa04723","Retrograde endocannabinoid signaling","4/468","148/8113",0.974818012563155,0.999999999145607,0.784688994544878,"GNAO1/CACNA1C/GNG2/GABRP",4]
["hsa04110","Cell cycle","3/468","126/8113",0.979264938532838,0.999999999145607,0.784688994544878,"TGFB3/CCND2/CCNA1",3]
["hsa01240","Biosynthesis of cofactors","4/468","155/8113",0.981309850237318,0.999999999145607,0.784688994544878,"UGT1A1/IDO1/UGT2B15/UGT1A10",4]
["hsa04932","Non-alcoholic fatty liver disease","4/468","155/8113",0.981309850237318,0.999999999145607,0.784688994544878,"PIK3CD/AKT3/IL6/ADIPOQ",4]
["hsa04720","Long-term potentiation","1/468","67/8113",0.981641106657737,0.999999999145607,0.784688994544878,"CACNA1C",1]
["hsa04622","RIG-I-like receptor signaling pathway","1/468","70/8113",0.984662300865659,0.999999999145607,0.784688994544878,"CXCL10",1]
["hsa01230","Biosynthesis of amino acids","1/468","75/8113",0.988635516992119,0.999999999145607,0.784688994544878,"TKTL1",1]
["hsa04721","Synaptic vesicle cycle","1/468","78/8113",0.9905074412544,0.999999999145607,0.784688994544878,"SNAP25",1]
["hsa04150","mTOR signaling pathway","3/468","155/8113",0.994777759303151,0.999999999145607,0.784688994544878,"PIK3CD/AKT3/IGF1",3]
["hsa04912","GnRH signaling pathway","1/468","93/8113",0.996144331846276,0.999999999145607,0.784688994544878,"CACNA1C",1]
["hsa04114","Oocyte meiosis","2/468","131/8113",0.996425075840135,0.999999999145607,0.784688994544878,"CPEB1/IGF1",2]
["hsa04916","Melanogenesis","1/468","101/8113",0.997617096089047,0.999999999145607,0.784688994544878,"GNAO1",1]
["hsa04140","Autophagy - animal","2/468","141/8113",0.997911667973646,0.999999999145607,0.784688994544878,"PIK3CD/AKT3",2]
["hsa05017","Spinocerebellar ataxia","2/468","143/8113",0.998125663728035,0.999999999145607,0.784688994544878,"PIK3CD/AKT3",2]
["hsa03013","Nucleocytoplasmic transport","1/468","108/8113",0.998436632613749,0.999999999145607,0.784688994544878,"EEF1A2",1]
["hsa05168","Herpes simplex virus 1 infection","14/468","495/8113",0.99946666656968,0.999999999145607,0.784688994544878,"ITGA5/POU2F2/PIK3CD/ITGB3/AKT3/ZNF432/HLA-DQA1/HLA-DMB/IL6/HLA-DPB1/CCL2/BIRC3/CCL5/HLA-DQB1",14]
["hsa04714","Thermogenesis","4/468","232/8113",0.999466740138048,0.999999999145607,0.784688994544878,"PRKG1/CREB5/NPR1/PLIN1",4]
["hsa05010","Alzheimer disease","9/468","384/8113",0.999690860378767,0.999999999145607,0.784688994544878,"CACNA1C/CYBB/PIK3CD/CSF1/AKT3/IL6/LPL/DKK4/TUBA3C",9]
["hsa04120","Ubiquitin mediated proteolysis","1/468","142/8113",0.999799261901946,0.999999999145607,0.784688994544878,"BIRC3",1]
["hsa05012","Parkinson disease","4/468","266/8113",0.999901521653355,0.999999999145607,0.784688994544878,"LRRK2/UCHL1/TUBA3C/DRD1",4]
["hsa05022","Pathways of neurodegeneration - multiple diseases","11/468","476/8113",0.999940307212508,0.999999999145607,0.784688994544878,"CACNA1C/CYBB/CSF1/LRRK2/NEFL/IL6/RYR2/UCHL1/NEFM/DKK4/TUBA3C",11]
["hsa04141","Protein processing in endoplasmic reticulum","1/468","171/8113",0.999965391035064,0.999999999145607,0.784688994544878,"CRYAB",1]
["hsa05016","Huntington disease","3/468","306/8113",0.99999814317964,0.999999999145607,0.784688994544878,"CREB5/TGM2/TUBA3C",3]
["hsa05014","Amyotrophic lateral sclerosis","4/468","364/8113",0.999999419406006,0.999999999145607,0.784688994544878,"NEFL/NRG1/NEFM/TUBA3C",4]
["hsa04740","Olfactory transduction","3/468","441/8113",0.999999999145607,0.999999999145607,0.784688994544878,"PRKG1/RGS2/PDE1A",3]