Table-S4:  The gene sets used in our work for marking 10 oncogenic pathways 												
Cell Cycle	HIPPO	MYC	NOTCH	NRF2	PI3K	TGF-Beta	RTK RAS	TP53	WNT			
CDKN1A	STK4	MAX	ARRDC1	NFE2L2	EIF4EBP1	TGFBR1	SPRED1	TP53	CHD8			
CDKN1B	STK3	MGA	CNTN6	KEAP1	AKT1	TGFBR2	SPRED2	MDM2	LEF1			
CDKN2A	SAV1	MLX	CREBBP	CUL3	AKT2	ACVR2A	SPRED3	MDM4	LGR4			
CDKN2B	LATS1	MLXIP	EP300		AKT3	ACVR1B	DAB2IP	ATM	LGR5			
CDKN2C	LATS2	MLXIPL	HES1		AKT1S1	SMAD2	SHOC2	CHEK2	LRP5			
CCND1	MOB1A	MNT	HES2		DEPDC5	SMAD3	PPP1CA	RPS6KA3	LRP6			
CCND2	MOB1B	MXD1	HES3		DEPTOR	SMAD4	SCRIB		LZTR1			
CCND3	YAP1	MXD3	HES4		INPP4B		PIN1		NDP			
CCNE1	WWTR1	MXD4	HES5		MAPKAP1		KSR1		PORCN			
CDK2	TEAD1	MXI1	HEY1		MLST8		KSR2		RSPO1			
CDK4	TEAD2	MYC	HEY2		MTOR		PEBP1		SFRP1			
CDK6	TEAD3	MYCL	HEYL		NPRL2		ERF		SFRP2			
RB1	TEAD4	MYCN	KAT2B		NPRL3		PEA15		SFRP4			
E2F1	PTPN14		KDM5A		PDK1		JAK2		SFRP5			
E2F3	NF2		NOTCH1		PIK3CA		IRS2		SOST			
	WWC1		NOTCH2		PIK3CB				TCF7L1			
	TAOK1		NOTCH3		PIK3R1				TLE1			
	TAOK2		NOTCH4		PIK3R2				TLE2			
	TAOK3		NOV		PIK3R3				TLE3			
	CRB1		NRARP		PPP2R1A				TLE4			
	CRB2		PSEN2		PTEN				WIF1			
	CRB3		LFNG		RHEB				ZNRF3			
	LLGL1		ITCH		RICTOR				CTNNB1			
	LLGL2		NCSTN		RPTOR				DVL1			
	HMCN1		SPEN		RPS6				DVL2			
	SCRIB		JAG1		RPS6KB1				DVL3			
	HIPK2		APH1A		STK11				FRAT1			
	FAT1		FBXW7		TSC1				FRAT2			
	FAT2		FHL1		TSC2				FZD1			
	FAT3		THBS2						FZD10			
	FAT4		HDAC2						FZD2			
	DCHS1		MFAP2						FZD3			
	DCHS2		CUL1						FZD4			
	CSNK1E		RFNG						FZD5			
	CSNK1D		NCOR1						FZD6			
	AJUBA		NCOR2						FZD7			
	LIMD1		MFAP5						FZD8			
	WTIP		HDAC1						FZD9			
			NUMB						WNT1			
			JAG2						WNT10A			
			MAML3						WNT10B			
			MFNG						WNT11			
			CIR1						WNT16			
			CNTN1						WNT2			
			MAML1						WNT3A			
			MAML2						WNT4			
			NUMBL						WNT5A			
			PSEN1						WNT5B			
			PSENEN						WNT6			
			RBPJ						WNT7A			
			RBPJL						WNT7B			
			RBX1						WNT8A			
			SAP30						WNT8B			
			SKP1						WNT9A			
			SNW1						WNT9B			
			CTBP1						AMER1			
			CTBP2						APC			
			ADAM10						AXIN1			
			APH1B						AXIN2			
			ADAM17						DKK1			
			DLK1						DKK2			
			DLL1						DKK3			
			DLL3						DKK4			
			DLL4						GSK3B			
			DNER						RNF43			
			DTX1						TCF7			
			DTX2						TCF7L2			
			DTX3						CHD4			
			DTX3L									
			DTX4									
			EGFL7