Table-S2: The gene sets used in our work for marking each immune signature aDCs APC co inhibition APC co stimulation B cells CCR CD8+ T cells Check-point Cytolytic activity DCs HLA iDCs Inflammation-promoting Macrophages Mast cells MHC class I Neutrophils NK cells Parainflammation pDCs T cell co-inhibition T cell co-stimulation T helper cells Tfh Th1 cells Th2 cells TIL Treg Type I IFN Reponse Type II IFN Reponse CD83 C10orf54 CD40 BACH2 CCL16 CD8A IDO1 PRF1 CCL17 HLA-E CD1A CCL5 C11orf45 CMA1 B2M EVI2B KLRC1 CXCL10 CLEC4C BTLA CD2 CD4 PDCD1 IFNG PMCH ITM2C IL12RB2 DDX4 GPR146 LAMP3 CD274 CD58 BANK1 TPO LAG3 GZMA CCL22 HLA-DPB2 CD1E CD19 CD68 MS4A2 HLA-A HSD17B11 KLRF1 PLAT CXCR3 C10orf54 CD226 CXCL13 TBX21 LAIR2 CD38 TMPRSS6 IFIT1 SELP CCL1 LGALS9 CD70 BLK TGFBR2 CTLA4 CD209 HLA-C CD8B CLEC5A TPSAB1 TAP1 KDM6B CCND1 GZMB CD160 CD27 CXCR5 CTLA4 SMAD2 THEMIS2 CTSC IFIT2 AHR PDCD1LG2 ICOSLG BTLA CXCL2 TNFRSF9 CCL13 HLA-J CXCL10 CYBB MEGF9 LGMN IL3RA CD244 CD28 STAT4 CXCR6 GLYR1 LAPTM4B IFIT3 PVRL3 SLAMF1 CD79A CCL14 ICOS HLA-DQB1 CXCL13 FUCA1 MNDA PLAUR IRF7 CD274 CD40LG CD38 GATA3 ICOS TFRC IRF7 TNFSF14 CD79B TGFBR3 CD80 HLA-DQB2 CXCL9 GPNMB NLRP12 AIM2 IRF8 CTLA4 ICOS IL12RB2 IL26 F5 RNF145 ISG20 TNFSF15 FCRL1 IL11RA PDCD1LG2 HLA-DQA2 GNLY HS3ST2 PADI4 MMP7 LILRA4 HAVCR2 SLAMF1 LTA TIGIT NETO2 MX1 TNFSF18 FCRL3 CCL11 TIGIT HLA-DQA1 GZMB LGMN SELL ICAM1 PHEX LAG3 TNFRSF18 CSF2 KLRD1 ADAT2 MX2 TNFSF4 HVCN1 IL4I1 CD70 HLA-A IFNG MMP9 TRANK1 MX2 PLD4 LAIR1 TNFRSF25 IRF4 CHST2 RSAD2 TNFSF8 RALGPS2 IL33 TNFSF9 HLA-DMA IL12A TM4SF19 VNN3 CXCL9 PTCRA TIGIT TNFRSF4 PRKCQ CTLA4 TNFSF10 TNFSF9 CXCL12 ICOSLG HLA-DOB IL12B ANXA1 TNFRSF8 FCRL5 NFE2L3 CXCL10 KIR3DL1 HLA-DRB1 IRF1 TLR2 TNFRSF9 SIRPG LIMA1 BMPER CD86 HLA-H PRF1 PLA2G2D TNFSF14 LPXN IL1R2 BMP8A PDCD1 HLA-B STAT1 ITGA2 IL2RG ICOS CXCL11 LAIR1 HLA-DRB5 TBX21 MX1 CCL5 HSDL2 IL21R TNFRSF8 HLA-DOA HMOX1 LCK HTATIP2 IL17B TNFSF15 HLA-DPB1 CD276 TRAF3IP3 FKBP1A TNFRSF9 TNFRSF14 HLA-DRA TIRAP CD86 TIGIT ILF2 IDO2 HLA-DRB6 IL33 MAL CCR8 CX3CR1 CD276 HLA-L PTGES LILRB1 LTA CCR8 CD40 HLA-F TNFRSF12A DOK2 SLC35F2 TNFSF12 TNFRSF4 HLA-G SCARB1 CD6 IL21R CSF3 TNFSF14 HLA-DMB CD14 PAG1 AHCYL1 TNFSF4 HHLA2 HLA-DPA1 BLNK LAX1 SOCS2 BMP3 CD244 IFIT3 PLEK ETV7 CX3CL1 CD274 RETNLB PIK3CD BCL2L1 BMP5 HAVCR2 IFIT2 SLAMF1 RRAGB CXCR2 CD27 ISG15 XCL1 ACSL4 TNFRSF10D BTLA OAS2 GPR171 CHRNA6 BMP2 LGALS9 REL XCL2 BATF CXCL14 TMIGD2 OAS3 TBX21 LAX1 CCL28 CD28 CD44 CD2 ADPRH CXCL3 CD48 PPARG CD53 TNFRSF4 BMP6 TNFRSF25 BST2 KLHL6 ANKRD10 CCL21 CD40LG OAS1 SLAMF6 CD274 CXCL9 ADORA2A NOX1 CD40 CASP1 CCL23 VTCN1 PLA2G2A SIT1 LY75 IL6 CD160 IFIT1 TNFRSF4 NPTN TNFRSF18 CD44 IFITM3 CD79A SSTR3 IL17RD TNFSF18 IL1RN CD247 GRSF1 IL17D TNFRSF18 LCP2 CSF2RB IL27 BTNL2 CD3D TMEM184C CCL7 C10orf54 CD27 NDFIP2 IL1R1 CD200R1 SH2D1A ZBTB38 CXCR4 TNFSF4 FYB ERI1 CXCR2P1 CD200 ARHGAP30 TRAF3 TGFB1I1 NRP1 ACAP1 NAB1 IFNGR1 CST7 HS3ST3B1 IL9R CD3G LAYN IL1RAPL1 IL2RB JAK1 IL11 CD3E VDR CSF1 FCRL3 LEPROT IL20RA CORO1A GCNT1 IL25 ITK PTPRJ TNFRSF4 TCL1A IKZF2 IL18 CYBB CSF1 ILF3 CSF2RB ENTPD1 CCL20 IKZF1 TNFRSF18 TNFRSF12A NCF4 METTL7A IL6ST DOCK2 KSR1 CXCL13 CCR2 SSH1 IL12B PTPRC CADM1 TNFRSF8 PLAC8 IL1R1 IL6R NCKAP1L ACP5 BMPR2 IL7R CHST7 IFNE 6-Sep THADA IL1RAPL2 CD28 CD177 IL3RA STAT4 NFAT5 BMP4 CD8A ZNF282 CCL24 LY9 MAGEH1 TNFSF13B CD48 CCR4 HCST IL2RA PTPRCAP IL32 SASH3 TNFRSF10C ARHGAP25 IL22RA1 LAT BMPR1A TRAT1 CXCR5 IL10RA CXCR3 PAX5 IFNA8 CCR7 IL17REL DOCK11 IFNB1 PARVG IFNAR1 SPNS1 TNFRSF1B CD52 CCL17 HCLS1 IFNL1 ARHGAP9 IL16 GIMAP6 IL1RL1 PRKCB ILK MS4A1 CCL25 GPR18 ILDR2 TBC1D10C CXCR1 GVINP1 IL36RN P2RY8 IL34 EVI2B TGFB1 VAMP5 IFNG KLRK1 IL19 SELL ILKAP MPEG1 BMP2K MS4A6A CCR10 ARHGAP15 ILDR1 MFNG EPO GZMK CCR7 SELPLG IL17C TARP IL23A GIMAP7 CCR5 FAM65B IL7 INPP5D EPOR ITGA4 CCL13 MZB1 IL2RG GPSM3 IL31RA STK10 TNFAIP6 CLEC2D IFNL2 IL16 BMP1 NLRC3 IL12RB1 GIMAP5 TNFAIP8 GIMAP4 IL4R IFFO1 TNFRSF6B CFH TNFAIP8L1 PVRIG TNFRSF10B CFHR1 IFNL3 CCL5 CXCL6 CXCL1 CCR3 TNFSF11 CSF1R IL21 IL1RAP IL12RB2 CCL1 IL17RA CCR1 IL1RN TNFRSF11B TNFRSF14 IL13 IL2RB BMP8B CCL2 IL24 IL18RAP TGFBI TNFSF10 TNFRSF11A CXCL5 IL5RA TNFSF9 IL1RL2 TNFRSF13C IL36G IL15RA TNFRSF21 CXCL8 IL22RA2 TNFAIP8L2 IL18R1 IFNLR1 CXCR6 CCL3L3 TNFRSF1A IL17RE IFNGR2 IL17RC TNFAIP8L3 ILVBL TGFBRAP1 CCL4L1 CSF2RA CCRN4L CCL26 TNFAIP1 CCRL2 IFNA10 TNFRSF17 IFNA13 IL20 IL18BP CCL3L1 TNFSF12-TNFSF13 IL5 IL23R IL26 TNF TGFA CSF2 IL1F10 CXCL17 TNFSF13 IFNA4 IL37 IL12A IL7R IFNA1 IL1A IL4 IL2 CCL22 CSF3R IL10 IFNK TGFB2 IL1R2 IL1B IL17F IL27RA IL15 TNFSF8 IL36B XCL1 CXCL16 TNFRSF19 IL3 CCL3 IFNA2 BMPR1B IFNA21 TNFSF18 CCL8 IL17RB TNFRSF25 IL22 IL10RB IFNAR2 CCL18 IFNA16 CSF2RB IL36A TNFAIP3 IL13RA2 IL13RA1 CCR9 TNFRSF10A IFNA7 IFNW1 XCL2 TNFSF14 CCR2 BMP15 BMP10 CCL15-CCL14 TGFBR1 IFNA5 BMP7 IFNA14 IL20RB IL10RA IFNA17 CCR6 TGFB3 CCL15 CCL4 CCL27 TNFRSF13B TNFAIP2 IL31 IL17A TNFSF15 CCL19 IFNA6 IL9