{"text_format":"3","workbook":"xlsx","n_sheets":18,"sheets":["Table 1","Table 2","Table 3","Table 4","Table S1","Table S2","Table S3","Table S4","Table S5","Table S6","Table S7","Table S8","Table S9","Table S10","Table S11","Table12","Table S13","Table S14"],"read":"whole","date_system":"1900"}

{"sheet":"Table 1","index":0,"n_rows":13,"n_cols":8,"rows_kept":13}
[null,"Table 1: Results of the Adonis testing for difference of Bray-Curtis distances between each couple of lines. "]
[{"$nulls":3},"B2-line","B12-line","B14-line","B15-line","B19-line"]
[null,null,"B12-line","0.0026 **"]
[null,null,"B14-line","0.0001 ***","0.0002 ***"]
[null,"p-values","B15-line","0.0026 **","0.0226 *","0.0001 ***"]
[null,null,"B19-line","0.2002 ","0.0043 **","0.0001 ***","0.2107 "]
[null,null,"B21-line","0.0002 ***","0.0001 ***","0.0001 ***","0.0041 **","0.0362 *"]
[null,null,"B12-line",36]
[null,"Number of","B14-line",87,19]
[null,"OTU differentially","B15-line",16,0,47]
[null,"abundant","B19-line",9,40,74,2]
[null,null,"B21-line",0,105,126,2,1]
[null,"The p-values are given and highlighted in bold letter when significant (*  <0.05. ** <0.01. and *** <0.001)."]

{"sheet":"Table 2","index":1,"n_rows":13,"n_cols":6,"rows_kept":13,"merged":[[6,1,7,1],[8,1,9,1]]}
[null,"Table 2: Effect of IBV vaccination on the α-diversity of the caecal microbial community of 9-weeks-old hens infected with IBV."]
[null,"OTU set (number)",null,"Vaccinated","Control","p-values"]
[null,"All OTU (487)","Richness",320,351,"7.0 x 10-4 ***"]
[null,null,"Chao1",342,374,"7.2 x 10-4 ***"]
[null,null,"Shannon","3.85","3.93",0.24]
[null,null,"InvSimpson","22.8","23.2",0.92]
[null,"OTU annoted to the Ruminococcaceae family (217 OTUs)","Richness",131,157,"1.1 x 10-7 ***"]
[null,null,"Chao1",140,165,"9.8 x 10-7 ***"]
[null,"OUT annoted to the Lachnospiraceae family (219 OTUs)","Richness",159,157,0.66]
[null,null,"Chao1",170,170,0.98]
[null,"α-diversity indices among the vaccinated and the control groups in the total population and in the Ruminococcaceae and Lachnospiraceae families separately."]
[null,"We indicated the mean of each indice in the vaccinated and not vaccinated (control) groups, and highlighted the p-value of the line effect when significant (*  <0.05, ** <0.01, and *** <0.001)."]
[null,"Alpha diversity indices are available in Additional File 5."]

{"sheet":"Table 3","index":2,"n_rows":31,"n_cols":9,"rows_kept":31,"merged":[[2,1,3,1],[2,2,3,2],[2,3,3,3],[2,4,3,4],[2,5,3,5],[2,6,3,6],[2,7,2,8]]}
[]
[null,"Table 3: Differential analysis on OTU abundances between the high and low responders to IBV vaccination."]
[null,"OTU","Phylum","Family","Genus","p-values","    adjusted      p-values","Mean relative abondance"]
[{"$nulls":7},"HR","LR"]
[null,"Cluster_9","Firmicutes","Ruminococcaceae","unknown genus","1.74 x 10-3","3.93 x 10-2","1.57 x 10-2","3.52 x 10-2"]
[null,"Cluster_358","-","-","CAG-352","2.14 x 10-5","3.39 x 10-3","7.26 x 10-5","2.62 x 10-4"]
[null,"Cluster_154","-","-","unknown genus","2.83 x 10-4","1.92 x 10-2","4.19 x 10-4","8.26 x 10-4"]
[null,"Cluster_630","-","-","Ruminococcaceae UCG-014","2.05 x 10-3","4.43 x 10-2","3.37 x 10-5","1.37 x 10-4"]
[null,"Cluster_302","-","-","unknown genus","2.25 x 10-3","4.56 x 10-2","1.11 x 10-4","2.73 x 10-4"]
[null,"Cluster_45","-","Lachnospiraceae","unknown genus","1.53 x 10-3","3.64 x 10-2","2.15 x 10-3","8.31 x 10-3"]
[null,"Cluster_549","-","-","[Ruminococcus] gauvreauii group","6.00 x 10-4","2.47 x 10-2","8.45 x 10-5","1.60 x 10-4"]
[null,"Cluster_105","-","-","Blautia","1.05 x 10-3","2.94 x 10-2","7.11 x 10-4","1.46 x 10-3"]
[null,"Cluster_679","-","-","unknown genus","2.30 x 10-3","4.56 x 10-2","7.23 x 10-5","1.34 x 10-4"]
[null,"Cluster_615","-","Defluviitaleaceae","Defluviitaleaceae UCG-011","9.94 x 10-4","2.94 x 10-2","6.47 x 10-5","1.84 x 10-4"]
[null,"Cluster_759","Proteobacteria","Enterobacteriaceae","Escherichia-Shigella","3.55 x 10-4","2.09 x 10-2","5.86 x 10-5","1.33 x 10-4"]
[null,"Cluster_65","Firmicutes","Ruminococcaceae","Ruminococcaceae UCG-014","7.98 x 10-4","2.70 x 10-2","7.16 x 10-3","1.45 x 10-3"]
[null,"Cluster_270","-","-","Angelakisella","1.48 x 10-5","3.39 x 10-3","5.45 x 10-4","7.18 x 10-5"]
[null,"Cluster_496","-","-","Ruminiclostridium 9","3.96 x 10-4","2.09 x 10-2","2.88 x 10-4","1.23 x 10-5"]
[null,"Cluster_370","-","-","[Eubacterium] coprostanoligenes group","2.81 x 10-4","1.92 x 10-2","2.98 x 10-4","9.84 x 10-5"]
[null,"Cluster_535","-","Lachnospiraceae","Lachnospiraceae ND3007 group","1.11 x 10-4","1.05 x 10-2","3.28 x 10-4","6.58 x 10-5"]
[null,"Cluster_77","-","-","unknown genus","7.57 x 10-4","2.70 x 10-2","3.86 x 10-3","1.14 x 10-3"]
[null,"Cluster_177","-","-","Eisenbergiella","5.15 x 10-4","2.45 x 10-2","1.14 x 10-3","1.94 x 10-4"]
[null,"Cluster_136","-","-","unknown genus","6.23 x 10-4","2.47 x 10-2","5.53 x 10-4","6.22 x 10-6"]
[null,"Cluster_471","-","-","Tyzzerella","9.52 x 10-6","3.39 x 10-3","1.46 x 10-4","3.18 x 10-5"]
[null,"Cluster_265","-","-","Tyzzerella 3","1.26 x 10-3","3.16 x 10-2","1.94 x 10-4","1.21 x 10-4"]
[null,"Cluster_567","-","-","CHKCI001","1.20 x 10-3","3.16 x 10-2","1.65 x 10-4","9.96 x 10-5"]
[null,"Cluster_354","-","unknown family","unknown genus","5.58 x 10-5","6.63 x 10-3","3.18 x 10-4","4.41 x 10-5"]
[null,"Cluster_198","-","unknown family","unknown genus","8.53 x 10-4","2.70 x 10-2","6.87 x 10-4","2.25 x 10-4"]
[null,"Summary of the differential analysis on caecal OTU abundances between the high and low responders (HR versus LR) to IBV vaccination in hens sacrified one week after an infectious challenge test. "]
[null,"Animals from both vaccine status groups were considered. The p-value, and adjusted p-value of the difference are given, with the mean relative abundance of each OTU in each group."]
[null,"OTU taxonomy is given at the phylum, family, and genus levels when available, with '-' indicating that the annotation is identical to the annotation mentioned above"]

{"sheet":"Table 4","index":3,"n_rows":33,"n_cols":12,"rows_kept":33}
[]
[null,"Table 4: Analysis of β-diversity on caecal microbiota  by Adonis test."]
[null,"Immune phenotype","Total population",null,"HR LR subset",null,"B2-line","B12-line","B14-line","B15-line","B19-line","B21-line"]
[null,"Thrombocytes","0.7875",null,"0.3597",null,"0.3854","0.6747","0.4885","0.4642","0.4817","0.9116"]
[null,"Heterophils","0.2127",null,"0.0958",null,"0.3361","0.5187","0.7261","0.6782","0.1503","0.3929"]
[null,"Monocytes","0.0652",null,"0.0011 **",null,"0.3555","0.3261","0.3319","0.7232","0.167","0.3921"]
[null,"B cells","0.948",null,"0.3314",null,"0.5813","0.3093","0.2768","0.654","0.8219","0.4106"]
[null,"TCR ϒδ+ T cells","0.5279",null,"0.1153",null,"0.2653","0.3873","0.7943","0.2256","0.4657","0.6562"]
[null,"Frequency of TCR1+CD8+  δϒ T cells","0.9901",null,"0.0282",null,"0.7113","0.5803","0.7014","0.2193","0.6564","0.0887"]
[null,"Frequency of TCR1+CD8-  δϒ T cells","0.2726",null,"0.2026",null,"0.1536","0.2715","0.6636","0.1653","0.485","0.6557"]
[null,"Frequency of (ab) T cells","0.9281",null,"0.7643",null,"0.6401","0.5714","0.7549","0.7187","0.4327","0.304"]
[null,"Frequency of TCR1 CD4+ (ab) T cells","0.7792",null,"0.0306",null,"0.8836","0.6046","0.5536","0.1578","0.2497","0.3738"]
[null,"Frequency of TCR1-CD4+ (ab) T cells","0.1922",null,"0.0152",null,"0.6701","0.4512","0.9586","0.1664","0.1688","0.6124"]
[null,"Frequency of TCR1-CD4+CD25+ (ab) T cells","0.5448",null,"0.3542",null,"0.2607","0.7578","0.9323","0.0187 *","0.0123 *","0.7122"]
[null,"Frequency of thrombocytes","0.4009",null,"0.367",null,"0.8106","0.2009","0.8692","0.7638","0.114","0.9845"]
[null,"CD45 expression on thrombocytes","0.2158",null,"0.0034",null,"0.5766","0.7907","0.3087","0.8339","0.1369","0.4162"]
[null,"CD45 expression on heterophils","0.2911",null,"0.0024",null,"0.9433","0.3954","0.7948","0.0176 *","0.5906","0.4321"]
[null,"MRC1L-B expression on monocytes","0.5999",null,"0.2007",null,"0.2807","0.1924","0.3859","0.7267","0.1934","0.7111"]
[null,"CD45 expression on monocytes","0.0303 *",null,"0.0655",null,"0.075","0.1889","0.1887","0.9327","0.099","0.0191 *"]
[null,"MHCII expression on monocytes","0.4604",null,"0.0593",null,"0.3164","0.3027","0.0729","0.9426","0.6507","0.6031"]
[null,"BU1 expression on B cells","0.0116 *",null,"0.0341",null,"0.3529","0.2249","0.0754","0.4018","0.0116 *","0.0272 *"]
[null,"IgM on B cells","0.0159 *",null,"0.2107",null,"0.5344","0.0906","0.4423","0.8499","0.7193","0.0985"]
[null,"TCRϒδ expression on δϒ T cells","0.0005 ***",null,"0.0002 ***",null,"0.1957","0.1574","0.0157 *","0.0354 *","0.6884","0.0079 **"]
[null,"CD8β expression on CD8αβ+ TCR δϒ cells","0.4938",null,"0.1592",null,"0.8397","0.6617","0.8826","0.5558","0.0876","0.3429"]
[null,"CD8β expression on CD8αβ+ T cells","0.3367",null,"0.9794",null,"0.9791","0.3527","0.4672","0.14","0.0943","0.8766"]
[null,"CD4 expression on CD4+ T cells","0.3352",null,"0.0194 *",null,"0.5588","0.3691","0.1203","0.1111","0.3149","0.122"]
[null,"CD4 expression on CD4+ CD25+ T cells","0.3052",null,"0.0517",null,"0.818","0.31","0.7042","0.1136","0.7025","0.7171"]
[null,"CD25 expression on CD4+ CD25+ T cells","0.7377",null,"0.2492",null,"0.9508","0.6318","0.6986","0.2565","0.3999","0.8431"]
[null,"MHCII expression on B cells","0.9944",null,"0.2672",null,"0.891","0.1637","0.1839","0.7596","0.1972","0.3862"]
[null,"IBV viral load (Log)","0.4865",null,"0.6536",null,"0.8333","0.486","0.6782","0.2484","0.5887","0.8556"]
[null,"Association between the microbiota and the concomitant immune phenotype are described through the p-value of Adonis test based on Bray-Curtis distance matrix"]
[null,"and each immune parameter level. The associations are described in the total population, in the subset of high (HR) and low (LR) responders to the vaccination,"]
[null," and in each line separately. When significant, the p-value of the effect is highlighted in bold characters  (*p<0.05, **<0.01, ***≤0.001)."]

{"sheet":"Table S1","index":4,"n_rows":103,"n_cols":26,"rows_kept":103,"merged":[[2,2,3,2],[2,3,3,3],[2,4,3,4],[2,5,3,5],[2,6,3,6],[2,7,2,8],[2,10,2,11],[2,13,2,14],[2,16,2,17],[2,19,2,20],[2,22,2,23],[2,25,3,25]]}
[]
[null,"Table S1: Mean relative abundances of phyla, order, families and genera according to their line and vaccine status."]
[null,"Taxonomic","Phylum","Class","Order","Family","Genus","B2-line",null,null,"B21-line",null,null,"B15-line",null,null,"B14-line",null,null,"B19-line",null,null,"B12-line",null,null,"Total Population"]
[null,"level",{"$nulls":5},"Cont","Vacc",null,"Cont","Vacc",null,"Cont","Vacc",null,"Cont","Vacc",null,"Cont","Vacc",null,"Cont","Vacc"]
[null,"Phylum","Firmicutes","-","-","-","-",{"v":0.988647870249183,"d":"0.99"},{"v":0.979696109172382,"d":"0.98"},null,{"v":0.9969949026335581,"d":"1.00"},{"v":0.97066582156494,"d":"0.97"},null,{"v":0.953137051730943,"d":"0.95"},{"v":0.943452205546701,"d":"0.94"},null,{"v":0.941870044165958,"d":"0.94"},{"v":0.935319234541952,"d":"0.94"},null,{"v":0.995349080732845,"d":"1.00"},{"v":0.966020945128152,"d":"0.97"},null,{"v":0.939184720952879,"d":"0.94"},{"v":0.899256427215023,"d":"0.90"},null,{"v":0.959747482,"d":"0.96"}]
[null,null,"Proteobacteria","-","-","-","-",{"v":0.0108593638937475,"d":"0.01"},{"v":0.0193979381711668,"d":"0.02"},null,{"v":0.00242721590049124,"d":"2.43E-03"},{"v":0.0285657983069556,"d":"0.03"},null,{"v":0.0452793471690564,"d":"0.05"},{"v":0.0558699813064208,"d":"0.06"},null,{"v":0.0571734838830632,"d":"0.06"},{"v":0.0639259835648217,"d":"0.06"},null,{"v":0.0040570272699243,"d":"4.06E-03"},{"v":0.0326867962733405,"d":"0.03"},null,{"v":0.0599586174364386,"d":"0.06"},{"v":0.0998632239925371,"d":"0.10"},null,{"v":0.0393916935,"d":"0.04"}]
[null,null,"Actinobacteria","-","-","-","-",{"v":0.0002529092726461,"d":"2.53E-04"},{"v":0.000446881333945263,"d":"4.47E-04"},null,{"v":0.000275169610246305,"d":"2.75E-04"},{"v":3.88658315870019E-4,"d":"3.89E-04"},null,{"v":0.000361753883639989,"d":"3.62E-04"},{"v":0.000296026077102546,"d":"2.96E-04"},null,{"v":0.000400611735776638,"d":"4.01E-04"},{"v":0.000419038561131644,"d":"4.19E-04"},null,{"v":0.000331094272619093,"d":"3.31E-04"},{"v":0.000648157735613891,"d":"6.48E-04"},null,{"v":0.000606527196652376,"d":"6.07E-04"},{"v":0.000456030069681246,"d":"4.56E-04"},null,{"v":0.0004026796,"d":"4.03E-04"}]
[null,null,"Fibrobacteres","-","-","-","-",{"v":2.39856584422936E-4,"d":"2.40E-04"},{"v":0.000456165899824633,"d":"4.56E-04"},null,{"v":0.00020725036759567,"d":"2.07E-04"},{"v":0.000379721812234117,"d":"3.80E-04"},null,{"v":5.66237005969216e-05,"d":"5.66E-05"},{"v":0.000381787069775399,"d":"3.82E-04"},null,{"v":0.00023278080689884,"d":"2.33E-04"},{"v":0.000335743332094746,"d":"3.36E-04"},null,{"v":1.7234255419425E-4,"d":"1.72E-04"},{"v":6.44100862893819E-4,"d":"6.44E-04"},null,{"v":0.000154982820241033,"d":"1.55E-04"},{"v":4.24318722758493E-4,"d":"4.24E-04"},null,{"v":0.0003112113,"d":"3.11E-04"}]
[null,null,"Tenericutes","-","-","-","-","absent",{"v":2.90542268089162e-06,"d":"2.91E-06"},null,{"v":9.54614881082261e-05,"d":"9.55E-05"},{"v":0,"d":"0.00E+00"},null,{"v":1.16522351576418E-3,"d":"1.17E-03"},{"v":0,"d":"0.00E+00"},null,{"v":0.000323079408303141,"d":"3.23E-04"},"absent",null,{"v":9.04551704175411e-05,"d":"9.05E-05"},{"v":0,"d":"0.00E+00"},null,{"v":9.5151593789196e-05,"d":"9.52E-05"},{"v":0,"d":"0.00E+00"},null,{"v":0.0001469337,"d":"1.47E-04"}]
[null,"Order","Firmicutes","Clostridia","Clostridiales","-","-",{"v":0.978914122591867,"d":"0.9789"},{"v":0.962852082282031,"d":"0.9629"},null,{"v":0.981891185141465,"d":"0.9819"},{"v":0.943160965868898,"d":"0.9432"},null,{"v":0.908472976595938,"d":"0.9085"},{"v":0.906302244603212,"d":"0.9063"},null,{"v":0.920020778311433,"d":"0.9200"},{"v":0.912197746716759,"d":"0.9122"},null,{"v":0.979443237622912,"d":"0.9794"},{"v":0.945701457145699,"d":"0.9457"},null,{"v":0.928929415624018,"d":"0.9289"},{"v":0.886216548342393,"d":"0.8862"},null,{"v":0.9382251879,"d":"0.9382"}]
[null,null,"-","Bacilli","Lactobacillales","-","-",{"v":0.00636928271399576,"d":"0.0064"},{"v":0.00669684035304633,"d":"0.0067"},null,{"v":0.00896449137758032,"d":"0.0090"},{"v":0.0171087872182319,"d":"0.0171"},null,{"v":0.0238128705445646,"d":"0.0238"},{"v":0.0137191145904392,"d":"0.0137"},null,{"v":0.0160218827798385,"d":"0.0160"},{"v":0.0190850771054666,"d":"0.0191"},null,{"v":0.00350935218523051,"d":"0.0035"},{"v":0.0152164766032161,"d":"0.0152"},null,{"v":0.0045758640775775,"d":"0.0046"},{"v":0.0112836526109405,"d":"0.0113"},null,{"v":0.0123197411,"d":"0.0123"}]
[null,null,"-","-","Bacillales","-","-",{"v":0.00336446494332106,"d":"0.0034"},{"v":0.0101471865373048,"d":"0.0101"},null,{"v":0.00613922611451341,"d":"0.0061"},{"v":0.0103960684778101,"d":"0.0104"},null,{"v":0.0208512045904396,"d":"0.0209"},{"v":0.0234308463530498,"d":"0.0234"},null,{"v":0.00582738307468687,"d":"0.0058"},{"v":0.00403641071972653,"d":"0.0040"},null,{"v":0.0123964909247021,"d":"0.0124"},{"v":5.10301137923669E-3,"d":"0.0051"},null,{"v":0.00567944125128282,"d":"0.0057"},{"v":1.75622626169011E-3,"d":"0.0018"},null,{"v":0.0092025529,"d":"0.0092"}]
[null,null,"Proteobacteria","Gammaproteobacteria","Multi-affiliation","-","-",{"v":0.0106158867832242,"d":"0.0106"},{"v":0.0190003589327342,"d":"0.0190"},null,{"v":0.00236678283491252,"d":"0.0024"},{"v":0.0279435956557152,"d":"0.0279"},null,{"v":0.0446113284642955,"d":"0.0446"},{"v":0.0545703999104577,"d":"0.0546"},null,{"v":0.0561851202868616,"d":"0.0562"},{"v":0.0624365337230325,"d":"0.0624"},null,{"v":0.0039648068567171,"d":"0.0040"},{"v":0.0320178651923491,"d":"0.0320"},null,{"v":0.0591176987903516,"d":"0.0591"},{"v":0.0981515019561785,"d":"0.0982"},null,{"v":0.0386390808,"d":"0.0386"}]
[null,null,"-","-","Enterobacteriales","-","-",{"v":2.4347711052325E-4,"d":"0.0002"},{"v":3.97579238432522E-4,"d":"0.0004"},null,{"v":6.04330655787165e-05,"d":"0.0001"},{"v":0.000622202651240404,"d":"0.0006"},null,{"v":0.000668018704760884,"d":"0.0007"},{"v":1.29958139596309E-3,"d":"0.0013"},null,{"v":0.000988363596201622,"d":"0.0010"},{"v":1.48944984178922E-3,"d":"0.0015"},null,{"v":9.22204132071944e-05,"d":"0.0001"},{"v":0.000668931080991362,"d":"0.0007"},null,{"v":0.000840918646086982,"d":"0.0008"},{"v":0.00171172203635859,"d":"0.0017"},null,{"v":0.0007526127,"d":"0.0008"}]
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[null,null,"-","-","-","Ruminococcaceae","Ruminococcaceae UCG-009",{"v":5.83267072401858E-4,"d":"5.83E-04"},{"v":1.26097048179631E-3,"d":"1.26E-03"},null,{"v":1.34734343768379E-3,"d":"1.35E-03"},{"v":0.00102325502563172,"d":"1.02E-03"},null,{"v":0.000790671818511675,"d":"7.91E-04"},{"v":4.7880340326985E-4,"d":"4.79E-04"},null,{"v":0.00083527321911788,"d":"8.35E-04"},{"v":0.000763957286421554,"d":"7.64E-04"},null,{"v":9.66463022203893E-4,"d":"9.66E-04"},{"v":1.72475686214558E-3,"d":"1.72E-03"},null,{"v":0.000744297125642211,"d":"7.44E-04"},{"v":0.00155368330178011,"d":"1.55E-03"},null,{"v":0.00101352762346719,"d":"1.01E-03"}]
[null,null,"-","-","-","-","Papillibacter",{"v":0.000140698151719455,"d":"1.41E-04"},{"v":0.000201650504456549,"d":"2.02E-04"},null,{"v":1.20133177079051E-4,"d":"1.20E-04"},{"v":1.57357442726341E-4,"d":"1.57E-04"},null,{"v":1.09347794307197E-4,"d":"1.09E-04"},{"v":9.59069884275324e-05,"d":"9.59E-05"},null,{"v":0.000162038331535647,"d":"1.62E-04"},{"v":7.78161766541792e-05,"d":"7.78E-05"},null,{"v":0.000160630011711214,"d":"1.61E-04"},{"v":1.79936685272878E-4,"d":"1.80E-04"},null,{"v":6.38458522868661e-05,"d":"6.38E-05"},{"v":1.03560654718359E-4,"d":"1.04E-04"},null,{"v":1.32189721839277E-4,"d":"1.32E-04"}]
[null,null,"-","-","-","-","Intestinimonas",{"v":0.00100943452598347,"d":"1.01E-03"},{"v":0.000912401192913448,"d":"9.12E-04"},null,{"v":0.000908759528380848,"d":"9.09E-04"},{"v":0.00075410629004526,"d":"7.54E-04"},null,{"v":0.000745440196398613,"d":"7.45E-04"},{"v":0.000836577850171755,"d":"8.37E-04"},null,{"v":1.02630941810358E-3,"d":"1.03E-03"},{"v":8.2938230849803E-4,"d":"8.29E-04"},null,{"v":0.00101481249611235,"d":"1.01E-03"},{"v":1.26831304161506E-3,"d":"1.27E-03"},null,{"v":0.000609769894071875,"d":"6.10E-04"},{"v":0.000798347770068614,"d":"7.98E-04"},null,{"v":0.00089745577303931,"d":"8.97E-04"}]
[null,null,"-","-","-","-","Ruminococcaceae NK4A214 group",{"v":0.00175643954463037,"d":"1.76E-03"},{"v":0,"d":"0.00E+00"},null,{"v":0.00155617302215219,"d":"1.56E-03"},{"v":0,"d":"0.00E+00"},null,{"v":0.000759541438664132,"d":"7.60E-04"},"absent",null,{"v":0.00410067013024402,"d":"4.10E-03"},"absent",null,{"v":0.00227383110798799,"d":"2.27E-03"},{"v":5.92630520945933e-06,"d":"5.93E-06"},null,{"v":1.00196870233443E-3,"d":"1.00E-03"},{"v":0,"d":"0.00E+00"},null,{"v":0.000919696714783525,"d":"9.20E-04"}]
[null,null,"-","-","-","-","Anaerofilum",{"v":0.000305366715758006,"d":"3.05E-04"},{"v":0.00013724255692829,"d":"1.37E-04"},null,{"v":0.000202704641422102,"d":"2.03E-04"},{"v":5.03857389327206e-05,"d":"5.04E-05"},null,{"v":9.82915242628919e-05,"d":"9.83E-05"},{"v":4.97751394704973e-05,"d":"4.98E-05"},null,{"v":0.000114674991877692,"d":"1.15E-04"},{"v":8.85410675070546e-05,"d":"8.85E-05"},null,{"v":1.44149611912579E-4,"d":"1.44E-04"},{"v":0.000133235712501474,"d":"1.33E-04"},null,{"v":7.39453368812006E-5,"d":"7.39E-05"},{"v":4.43169712019246e-05,"d":"4.43E-05"},null,{"v":1.21273918318402E-4,"d":"1.21E-04"}]
[null,null,"-","-","-","-","CAG-352",{"v":0.000736076077023374,"d":"7.36E-04"},{"v":0.000204072411241038,"d":"2.04E-04"},null,{"v":0.000121231177195895,"d":"1.21E-04"},{"v":0.000177315976329075,"d":"1.77E-04"},null,{"v":0.000589470100308265,"d":"5.89E-04"},{"v":0.0006473322034195,"d":"6.47E-04"},null,{"v":0.000177135385058232,"d":"1.77E-04"},{"v":0.000271397872414443,"d":"2.71E-04"},null,{"v":0.000541283858406224,"d":"5.41E-04"},{"v":3.37812832598015E-4,"d":"3.38E-04"},null,{"v":0.000744205957774256,"d":"7.44E-04"},{"v":0.000807733652657502,"d":"8.08E-04"},null,{"v":4.42741857363439E-4,"d":"4.43E-04"}]
[null,null,"-","-","-","-","Caproiciproducens",{"v":0.000390432110525829,"d":"3.90E-04"},{"v":0.000149196044690379,"d":"1.49E-04"},null,{"v":7.34655091889503e-05,"d":"7.35E-05"},{"v":9.48207950007578e-05,"d":"9.48E-05"},null,{"v":0.000504604441263206,"d":"5.05E-04"},{"v":0.000225576095498744,"d":"2.26E-04"},null,{"v":9.14905438655809e-05,"d":"9.15E-05"},{"v":5.39377757914219e-05,"d":"5.39E-05"},null,{"v":0.000373472233101143,"d":"3.73E-04"},{"v":0.00014886900008534,"d":"1.49E-04"},null,{"v":0.00163825385716844,"d":"1.64E-03"},{"v":0.000246400363369727,"d":"2.46E-04"},null,{"v":3.07055396754771E-4,"d":"3.07E-04"}]
[null,null,"-","-","-","-","Angelakisella",{"v":0.000584428075064308,"d":"5.84E-04"},{"v":0.000268606524404758,"d":"2.69E-04"},null,{"v":0.000768557935453431,"d":"7.69E-04"},{"v":6.01319972866721E-4,"d":"6.01E-04"},null,{"v":2.04364142174963E-4,"d":"2.04E-04"},{"v":1.44748487483535e-05,"d":"1.45E-05"},null,{"v":7.79276346217129e-05,"d":"7.79E-05"},{"v":3.88219056134844e-05,"d":"3.88E-05"},null,{"v":7.81110898804836e-05,"d":"7.81E-05"},{"v":8.39617302821483e-05,"d":"8.40E-05"},null,{"v":7.59071234436773e-05,"d":"7.59E-05"},{"v":9.33635751032923e-05,"d":"9.34E-05"},null,{"v":0.000246118436341394,"d":"2.46E-04"}]
[null,null,"-","-","-","-","Candidatus Soleaferrea",{"v":1.32214880133486E-3,"d":"1.32E-03"},{"v":0.000292384006925253,"d":"2.92E-04"},null,{"v":2.35634053712828E-3,"d":"2.36E-03"},{"v":1.39783681791084E-4,"d":"1.40E-04"},null,{"v":0.00100314328303859,"d":"1.00E-03"},{"v":0.000186571551972597,"d":"1.87E-04"},null,{"v":0.000209384309303662,"d":"2.09E-04"},{"v":5.11210341638178e-05,"d":"5.11E-05"},null,{"v":2.57548566731222E-3,"d":"2.58E-03"},{"v":0.000334623600961918,"d":"3.35E-04"},null,{"v":0.000404644093542218,"d":"4.05E-04"},{"v":0.000243042391017093,"d":"2.43E-04"},null,{"v":0.00077344850722091,"d":"7.73E-04"}]
[null,null,"-","-","-","Family XIII","Family XIII UCG-001",{"v":0.000225074319774324,"d":"2.25E-04"},{"v":9.56496227088438e-05,"d":"9.56E-05"},null,{"v":0.000213983804193755,"d":"2.14E-04"},{"v":6.68504324242715e-05,"d":"6.69E-05"},null,{"v":1.69358452138202E-4,"d":"1.69E-04"},{"v":1.23688663574724E-4,"d":"1.24E-04"},null,{"v":8.90804147268306e-05,"d":"8.91E-05"},{"v":1.42762662897649E-5,"d":"1.43E-05"},null,{"v":0.000344827681714707,"d":"3.45E-04"},{"v":0.000154967765776292,"d":"1.55E-04"},null,{"v":1.0092233349291E-4,"d":"1.01E-04"},{"v":1.10896862535879E-4,"d":"1.11E-04"},null,{"v":0.000143932127667649,"d":"1.44E-04"}]
[null,null,"-","-","-","-","Family XIII AD3011 group",{"v":0.000281780331927393,"d":"2.82E-04"},{"v":1.099347542863E-4,"d":"1.10E-04"},null,{"v":0.000240407434793019,"d":"2.40E-04"},{"v":8.5779661525065e-05,"d":"8.58E-05"},null,{"v":0.000489858644957137,"d":"4.90E-04"},{"v":9.52223962535691e-05,"d":"9.52E-05"},null,{"v":0.000285868351221833,"d":"2.86E-04"},{"v":1.13710803897268e-06,"d":"1.14E-06"},null,{"v":0.000208074051711336,"d":"2.08E-04"},{"v":1.17234730639761E-4,"d":"1.17E-04"},null,{"v":0.000327963346952991,"d":"3.28E-04"},{"v":5.58363079303525E-5,"d":"5.58E-05"},null,{"v":0.000187644966847032,"d":"1.88E-04"}]
[null,null,"-","-","-","-","[Eubacterium] nodatum group",{"v":0.000130288952847006,"d":"1.30E-04"},{"v":0.000143642250102329,"d":"1.44E-04"},null,{"v":1.60345031982339E-4,"d":"1.60E-04"},{"v":0.000191713286297266,"d":"1.92E-04"},null,{"v":0.000197830104780045,"d":"1.98E-04"},{"v":7.53842433398402e-05,"d":"7.54E-05"},null,{"v":1.39042890443296E-4,"d":"1.39E-04"},{"v":8.86022585236778e-05,"d":"8.86E-05"},null,{"v":0.000154537095446274,"d":"1.55E-04"},{"v":1.37008804109595E-4,"d":"1.37E-04"},null,{"v":0.000134544187642784,"d":"1.35E-04"},{"v":1.39303428573066E-4,"d":"1.39E-04"},null,{"v":1.41180742010444E-4,"d":"1.41E-04"}]
[null,null,"-","-","-","Defluviitaleaceae","Defluviitaleaceae UCG-011",{"v":6.97966027889569E-5,"d":"6.98E-05"},{"v":0,"d":"0.00E+00"},null,{"v":0.000235706211243029,"d":"2.36E-04"},{"v":0,"d":"0.00E+00"},null,{"v":0.000228524964241231,"d":"2.29E-04"},"absent",null,{"v":0.000169833311770233,"d":"1.70E-04"},"absent",null,{"v":0.00051180668477042,"d":"5.12E-04"},{"v":1.24452409398646E-4,"d":"1.24E-04"},null,{"v":2.25043948931935E-4,"d":"2.25E-04"},"absent",null,{"v":1.27971955435715E-4,"d":"1.28E-04"}]
[null,null,"Actinobacteria","Coriobacteriia","Coriobacteriales","Eggerthellaceae","CHKCI002",{"v":0.000350588460170467,"d":"3.51E-04"},{"v":0.000460921108213488,"d":"4.61E-04"},null,{"v":0.000338890334768682,"d":"3.39E-04"},{"v":0.000443107683962233,"d":"4.43E-04"},null,{"v":0.000435357135797665,"d":"4.35E-04"},{"v":3.19314794923913E-4,"d":"3.19E-04"},null,{"v":0.00049183367921088,"d":"4.92E-04"},{"v":3.84656795830986E-4,"d":"3.85E-04"},null,{"v":3.57924770255038E-4,"d":"3.58E-04"},{"v":6.53872721976597E-4,"d":"6.54E-04"},null,{"v":0.000729537696449768,"d":"7.30E-04"},{"v":0.000519776665335655,"d":"5.20E-04"},null,{"v":0.000450917695731748,"d":"4.51E-04"}]
[null,null,"Proteobacteria","Gammaproteobacteria","Enterobacteriales","Enterobacteriaceae","Escherichia-Shigella",{"v":3.13383822081494E-4,"d":"3.13E-04"},{"v":0.000382199394018239,"d":"3.82E-04"},null,{"v":5.98838442259416e-05,"d":"5.99E-05"},{"v":0.000626961703301517,"d":"6.27E-04"},null,{"v":0.000653695200466736,"d":"6.54E-04"},{"v":0.000994995813198468,"d":"9.95E-04"},null,{"v":0.00112151886741104,"d":"1.12E-03"},{"v":0.00111267570387203,"d":"1.11E-03"},null,{"v":8.18834205468656e-05,"d":"8.19E-05"},{"v":0.000711645132741664,"d":"7.12E-04"},null,{"v":0.000827416587982187,"d":"8.27E-04"},{"v":1.71393367227773E-3,"d":"1.71E-03"},null,{"v":0.000709948314555009,"d":"7.10E-04"}]
[null,null,"-","-","-","-","Proteus",{"v":7.74416769964961E-6,"d":"7.74E-06"},{"v":1.94179150301092e-05,"d":"1.94E-05"},null,{"v":1.64350540243235e-06,"d":"1.64E-06"},{"v":2.31734071619547e-05,"d":"2.32E-05"},null,{"v":0.000232009078456658,"d":"2.32E-04"},{"v":5.03249625920831E-4,"d":"5.03E-04"},null,{"v":1.07378019328788E-4,"d":"1.07E-04"},{"v":0.000296112576545374,"d":"2.96E-04"},null,"absent",{"v":1.47876570719002E-5,"d":"1.48E-05"},null,{"v":0.000180502505646425,"d":"1.81E-04"},{"v":9.74846085543378e-05,"d":"9.75E-05"},null,{"v":0.000122576790364796,"d":"1.23E-04"}]
[null,null,"Fibrobacteres","Fibrobacteria","Fibrobacterales","Fibrobacteraceae","Fibrobacter",{"v":0.000311677090843395,"d":"3.12E-04"},{"v":0.000475699660949721,"d":"4.76E-04"},null,{"v":0.000227894197829023,"d":"2.28E-04"},{"v":4.20708307983537E-4,"d":"4.21E-04"},null,{"v":7.27271407509856e-05,"d":"7.27E-05"},{"v":0.000437831067229384,"d":"4.38E-04"},null,{"v":0.000269608871290124,"d":"2.70E-04"},{"v":3.32940704385008E-4,"d":"3.33E-04"},null,{"v":2.37645436860404E-4,"d":"2.38E-04"},{"v":0.000645357648095814,"d":"6.45E-04"},null,{"v":1.8094354797381E-4,"d":"1.81E-04"},{"v":0.000455984013020753,"d":"4.56E-04"},null,{"v":0.000343232747639333,"d":"3.43E-04"}]
[null,"Vaccinated (Vacc) animals againt IBV, (Cont) control animal that were not vaccinated for IBV. "]
[null,"For the composition at the genus level, we separated the genera according to their level of mean relative abundance in the total population (above 5%, 1%, 0.1%, 0.01%, or below 0.01%)"]

{"sheet":"Table S2","index":5,"n_rows":39,"n_cols":7,"rows_kept":39,"merged":[[2,2,2,3]]}
[]
[null,"Table S2: Co-abundance network at the genus level."]
[null,"Correlation","Couple of genera",null,"Correlation","p-values","adjusted p-values"]
[null,"Positvie","Escherichia-Shigella","Gammaproteobactria (c) ",{"v":0.9503624,"d":"0.95"},{"v":0,"d":"0.00E+00"},{"v":0,"d":"0.00E+00"}]
[null,null,"CAG-352","Ruminococcaceae (f)",{"v":0.8714116,"d":"0.87"},{"v":0,"d":"0.00E+00"},{"v":0,"d":"0.00E+00"}]
[null,null,"CAG-352","Caproiciproducens",{"v":0.8043943,"d":"0.80"},{"v":0,"d":"0.00E+00"},{"v":0,"d":"0.00E+00"}]
[null,null,"Caproiciproducens","Ruminococcaceae (f)",{"v":0.7737418,"d":"0.77"},{"v":0,"d":"0.00E+00"},{"v":0,"d":"0.00E+00"}]
[null,null,"Anaerosporobacter","Negativibacillus",{"v":0.718005,"d":"0.72"},{"v":4.440892e-16,"d":"4.44E-16"},{"v":2.270184e-13,"d":"2.27E-13"}]
[null,null,"Ruminococcaceae NK4A214 group","Defluviitaleaceae UCG-011",{"v":0.6609627,"d":"0.66"},{"v":5.595524e-13,"d":"5.60E-13"},{"v":2.383693e-10,"d":"2.38E-10"}]
[null,null,"Ruminococcaceae NK4A214 group","Lachnospira",{"v":0.6414641,"d":"0.64"},{"v":4.284129e-12,"d":"4.28E-12"},{"v":1.564319e-09,"d":"1.56E-09"}]
[null,null,"Ruminococcaceae UCG-014"," Candidatus Soleaferrea",{"v":0.6053715,"d":"0.61"},{"v":1.293397E-10,"d":"1.29E-10"},{"v":4.132402E-8,"d":"4.13E-08"}]
[null,null,"Lachnospira","Defluviitaleaceae UCG-011",{"v":0.5905485,"d":"0.59"},{"v":4.647691e-10,"d":"4.65E-10"},{"v":1.319944e-07,"d":"1.32E-07"}]
[null,null,"Pseudoflavonifractor","Ruminococcaceae UCG-014",{"v":0.5882274,"d":"0.59"},{"v":5.645409e-10,"d":"5.65E-10"},{"v":1.442966e-07,"d":"1.44E-07"}]
[null,null,"Lachnospiraceae NC2004 group","Negativibacillus",{"v":0.5835403,"d":"0.58"},{"v":8.321992e-10,"d":"8.32E-10"},{"v":1.933728e-07,"d":"1.93E-07"}]
[null,null,"Oscillibacter","Fibrobacter",{"v":0.5788997,"d":"0.58"},{"v":1.214708E-9,"d":"1.21E-09"},{"v":2.587329e-07,"d":"2.59E-07"}]
[null,null,"Pseudoflavonifractor"," Candidatus Soleaferrea",{"v":0.5760004,"d":"0.58"},{"v":1.533874E-9,"d":"1.53E-09"},{"v":3.015832e-07,"d":"3.02E-07"}]
[null,null,"Oscillibacter","unknown genus",{"v":0.5742464,"d":"0.57"},{"v":1.764444E-9,"d":"1.76E-09"},{"v":3.221371e-07,"d":"3.22E-07"}]
[null,null,"Bacillaceae (f)","Ruminococcaceae UCG-014",{"v":0.5711807,"d":"0.57"},{"v":2.249335e-09,"d":"2.25E-09"},{"v":3.832867e-07,"d":"3.83E-07"}]
[null,null,"Gammaproteobactria (c) ","Anaerostipes",{"v":0.5610069,"d":"0.56"},{"v":4.947195e-09,"d":"4.95E-09"},{"v":7.903143e-07,"d":"7.90E-07"}]
[null,null,"Flavonifractor","Oscillibacter",{"v":0.5531143,"d":"0.55"},{"v":8.955241e-09,"d":"8.96E-09"},{"v":1.204716e-06,"d":"1.20E-06"}]
[null,null,"Family XIII AD3011 group","Ruminococcaceae NK4A214 group",{"v":0.5501112,"d":"0.55"},{"v":1.117877E-8,"d":"1.12E-08"},{"v":1.428647E-6,"d":"1.43E-06"}]
[null,null,"Roseburia","Tyzzerella",{"v":0.5485475,"d":"0.55"},{"v":1.253634E-8,"d":"1.25E-08"},{"v":1.525852E-6,"d":"1.53E-06"}]
[null,null,"Ruminiclostridium 9","Oscillibacter",{"v":0.542604,"d":"0.54"},{"v":1.927795E-8,"d":"1.93E-08"},{"v":2.239748E-6,"d":"2.24E-06"}]
[null,null,"Escherichia-Shigella","Anaerostipes",{"v":0.5390436,"d":"0.54"},{"v":2.484807e-08,"d":"2.48E-08"},{"v":2.761377e-06,"d":"2.76E-06"}]
[null,null,"Intestinimonas","Ruminiclostridium 9",{"v":0.5367231,"d":"0.54"},{"v":2.927196e-08,"d":"2.93E-08"},{"v":3.117464e-06,"d":"3.12E-06"}]
[null,null,"Sellimonas","Anaerostipes",{"v":0.5319121,"d":"0.53"},{"v":4.095322E-8,"d":"4.10E-08"},{"v":4.187057E-6,"d":"4.19E-06"}]
[null,null,"Lachnospiraceae FCS020 group","GCA-900066575",{"v":0.524204,"d":"0.52"},{"v":6.938489e-08,"d":"6.94E-08"},{"v":6.821068e-06,"d":"6.82E-06"}]
[null,null,"Pseudoflavonifractor","Oscillospira",{"v":0.5186202,"d":"0.52"},{"v":1.008365E-7,"d":"1.01E-07"},{"v":8.591272e-06,"d":"8.59E-06"}]
[null,null,"Family XIII AD3011 group","CHKCI001",{"v":0.5055639,"d":"0.51"},{"v":2.355516E-7,"d":"2.36E-07"},{"v":1.824454e-05,"d":"1.82E-05"}]
[null,"Negative","Eisenbergiella","Candidatus Soleaferrea",{"v":-0.5590014,"d":"-0.56"},{"v":5.760817e-09,"d":"5.76E-09"},{"v":8.661558e-07,"d":"8.66E-07"}]
[null,null,"Pseudoflavonifractor","Eisenbergiella",{"v":-0.5571284,"d":"-0.56"},{"v":6.635027e-09,"d":"6.64E-09"},{"v":9.421739e-07,"d":"9.42E-07"}]
[null,null,"unknown genus","Candidatus Soleaferrea",{"v":-0.5223292,"d":"-0.52"},{"v":7.872305e-08,"d":"7.87E-08"},{"v":7.345562e-06,"d":"7.35E-06"}]
[null,null,"Ruminococcaceae NK4A214 group","Eisenbergiella",{"v":-0.5220025,"d":"-0.52"},{"v":8.046782e-08,"d":"8.05E-08"},{"v":7.345562e-06,"d":"7.35E-06"}]
[null,null,"Eisenbergiella","Ruminococcaceae UCG-014",{"v":-0.5212195,"d":"-0.52"},{"v":8.480168e-08,"d":"8.48E-08"},{"v":7.474244e-06,"d":"7.47E-06"}]
[null,null,"Anaerostipes","Ruminococcaceae UCG-014",{"v":-0.5161642,"d":"-0.52"},{"v":1.186078E-7,"d":"1.19E-07"},{"v":9.779401e-06,"d":"9.78E-06"}]
[null,null,"Lachnospiraceae FCS020 group","unknown genus",{"v":-0.5085562,"d":"-0.51"},{"v":1.945329e-07,"d":"1.95E-07"},{"v":1.553831e-05,"d":"1.55E-05"}]
[null,null,"Oscillibacter","Ruminococcaceae UCG-014",{"v":-0.5008151,"d":"-0.50"},{"v":3.179353E-7,"d":"3.18E-07"},{"v":2.390125e-05,"d":"2.39E-05"}]
[null,"Correlation and their associated p-value between relative abundances of each couple of genus from the cecal microbiota of laying hens"]
[null,"that displayed a significant correlation. Unknown annotation at the genus level are given at a lower rank: (f) family, or (c) class."]

{"sheet":"Table S3","index":6,"n_rows":9,"n_cols":15,"rows_kept":9,"merged":[[2,2,2,7],[2,8,2,13],[2,14,3,14]]}
[]
[null,"Table S3: α-diversity indices among the lines in the vaccinated and control group."]
[null,null,"Vaccinated",{"$nulls":5},"Control",{"$nulls":5},"p-values"]
[null,null,"B2-line","B12-line","B14-line","B15-line","B19-line","B21-line","B2-line","B12-line","B14-line","B15-line","B19-line","B21-line"]
[null,"Richness",335,325,299,308,321,332,347,351,343,349,358,358,"0.57"]
[null,"Chao1",361,348,321,327,339,352,373,369,364,375,378,381,"0.58"]
[null,"Shannon","4.0","3.7","3.6","3.9","3.9","4.0","3.8","3.8","3.9","3.9","4.0","4.0","0.13"]
[null,"InvSimpson","27.5","19.6","17.1","24.2","23.3","25.1","20.1","20.2","24.8","23.6","27.3","22.4","0.51"]
[null,"We indicated the mean of each indices in each group of line and vaccine status, and the p-value of the line effect. Alpha diversity indices are available in Additional File 5."]

{"sheet":"Table S4","index":7,"n_rows":15,"n_cols":8,"rows_kept":15,"merged":[[3,1,7,1],[8,1,12,1]]}
[]
[null,"Table S4: Results of the Adonis testing for the difference of Bray-Curtis distance between each couple of lines. "]
[null,"Vaccine status",null,"B2-line","B12-line","B14-line","B15-line","B19-line"]
[null,"Vaccinated","B12-line","0.0027 **"]
[null,null,"B14-line","0.0003 ***","0.0252 *"]
[null,null,"B15-line","0.056","0.1371","0.0007 ***"]
[null,null,"B19-line","0.2476","0.1132","0.002 **","0.5216"]
[null,null,"B21-line","0.2331","0.0299 *","0.0028 **","0.619","0.5428"]
[null,"Control","B12-line","0.1325"]
[null,null,"B14-line","0.0018 **","0.0006 ***"]
[null,null,"B15-line","0.0609","0.1105","0.003 **"]
[null,null,"B19-line","0.2363","0.0105 *","0.0004 ***","0.2133"]
[null,null,"B21-line","0.0008 ***","0.0004 ***","0.0001 ***","0.0024 **","0.0054 **"]
[null,"Results are given according to the vaccine status: vaccinated (vacc) or not vaccinated (control)."]
[null," The p-values are given and highlighted in bold characters  when significant (*  <0.05, ** <0.01, and *** <0.001)."]

{"sheet":"Table S5","index":8,"n_rows":28,"n_cols":9,"rows_kept":28,"merged":[[1,1,1,7],[3,1,4,1],[10,1,11,1],[17,1,18,1],[23,1,24,1],[27,1,27,7]]}
[]
[null,"Table S5: Number of OTUs per genus with significantly different relative abundance between couple of lines."]
[{"$nulls":3},"B21-line","B2-line","B12-line","B15-line","B19-line","B14-line"]
[null,"Genera with more abundant OTU in B14 line","   Ruminococcus torques group",13,8,5,7,6,"-"]
[null,null,"   Escherichia-Shigella",3,3,0,0,2,"-"]
[null,null,"   Tyzzerella 3",0,1,2,0,3,"-"]
[null,null,"   Fusicatenibacter",2,2,0,0,2,"-"]
[null,null,"   Eisenbergiella",2,3,0,2,1,"-"]
[null,null,"   Sellimonas",3,3,0,0,2,"-"]
[null,null,"   Lachnoclostridium",1,1,0,2,2,"-"]
[null,"Genera with less abundant OTU in B14 line","   Ruminococcaceae UCG-014",11,11,3,5,6,"-"]
[null,null,"   Ruminococcus torques group",2,2,0,1,1,"-"]
[null,null,"   Ruminiclostridium 5",2,4,0,1,5,"-"]
[null,null,"   GCA-900066575",7,0,0,2,1,"-"]
[null,null,"   DTU089",2,0,0,2,1,"-"]
[null,null,"   Lachnospiraceae UCG-008",2,2,0,3,0,"-"]
[null,null,"   Lachnospiraceae NK4A136",1,2,0,0,2,"-"]
[null,"Genera with more abundant OTU in B21 line","      Ruminococcaceae UCG-014","-",0,5,0,0,11]
[null,null,"      Lachnoclostridium","-",0,3,0,0,2]
[null,null,"      Lachnospiraceae UCG-008","-",0,4,0,0,2]
[null,null,"      GCA-900066575 ","-",0,4,0,0,7]
[null,null,"      DTU089","-",0,2,0,0,2]
[null,null,"     Ruminococcus torques group","-",0,3,0,0,2]
[null,"Genera with less abundant OTU in B21 line","      Oscillibacter","-",0,4,0,0,2]
[null,null,"      Flavonifractor","-",0,5,0,0,5]
[null,null,"      Escherichia-Shigella","-",0,4,0,0,3]
[null,null,"      Ruminococcus 1","-",0,2,0,0,2]
[null,"Only genera that displayed at least 2 OTUs differing between at least two couple of line are shown.  "]

{"sheet":"Table S6","index":9,"n_rows":582,"n_cols":11,"rows_kept":582,"merged":[[2,2,3,2],[2,3,3,3],[2,4,3,4],[2,5,3,5],[2,6,3,6],[2,7,3,8],[2,9,3,9],[2,10,3,10]]}
[]
[null,"Table S6: Summary of the differential analysis on caecal OTU abundance between each couple of line in hen sacrified one week after an infectious challenge test. "]
[null,"Couple of line","OTU","Phylum","Family","Genus","Species","Mean relative abundance",null,"p-values","adjusted  p-values"]
[null,"(number of differential OTU)"]
[null,"B2-B12 (36 OTUs)",{"$nulls":5},"B2","B12"]
[null,null,"Cluster_67","Firmicutes","Ruminococcaceae","Ruminococcaceae UCG-014","unknown species",{"v":0.00121191196105002,"d":"1.21E-03"},{"v":0.00622549647007364,"d":"6.23E-03"},{"v":0.00382368484870936,"d":"3.82E-03"},{"v":0.0486457683530247,"d":"4.86E-02"}]
[null,null,"Cluster_630","-","-","-","unknown species",{"v":2.45961251875208e-05,"d":"2.46E-05"},{"v":0.00021476627563363,"d":"2.15E-04"},{"v":7.13189650497728e-05,"d":"7.13E-05"},{"v":0.00611459700426351,"d":"6.11E-03"}]
[null,null,"Cluster_37","-","-","Oscillibacter","unknown species",{"v":0.00979691540445768,"d":"9.80E-03"},{"v":0.00517179798948191,"d":"5.17E-03"},{"v":0.000340919294169612,"d":"3.41E-04"},{"v":0.0130117530608069,"d":"1.30E-02"}]
[null,null,"Cluster_313","-","-","-","unknown species",{"v":0.000731410934278614,"d":"7.31E-04"},{"v":1.02525226173308E-4,"d":"1.03E-04"},{"v":1.87350894479352E-3,"d":"1.87E-03"},{"v":0.037307265074584,"d":"3.73E-02"}]
[null,null,"Cluster_137","-","-","unknown genus","unknown species",{"v":1.63193390144343E-3,"d":"1.63E-03"},{"v":0.000374668662927819,"d":"3.75E-04"},{"v":8.01038908855482e-05,"d":"8.01E-05"},{"v":0.00611459700426351,"d":"6.11E-03"}]
[null,null,"Cluster_404","-","-","unknown genus","unknown species",{"v":1.35419582026662e-05,"d":"1.35E-05"},{"v":0.000299166065155004,"d":"2.99E-04"},{"v":0.000772428676942882,"d":"7.72E-04"},{"v":0.0198137768900034,"d":"1.98E-02"}]
[null,null,"Cluster_623","-","-","unknown genus","unknown species",{"v":1.14381191623949E-5,"d":"1.14E-05"},{"v":2.02323078362511E-4,"d":"2.02E-04"},{"v":0.000509907125411003,"d":"5.10E-04"},{"v":0.015569164229216,"d":"1.56E-02"}]
[null,null,"Cluster_27","-","-","unknown genus","unknown species",{"v":0.00104806644421175,"d":"1.05E-03"},{"v":0.0153913158859369,"d":"1.54E-02"},{"v":0.00283394002802544,"d":"2.83E-03"},{"v":0.0416946765724071,"d":"4.17E-02"}]
[null,null,"Cluster_517","-","-","Ruminiclostridium 9","unknown species",{"v":1.51245224355531E-4,"d":"1.51E-04"},{"v":3.49363157857963e-05,"d":"3.49E-05"},{"v":1.11069189471751E-3,"d":"1.11E-03"},{"v":0.0242236613228867,"d":"2.42E-02"}]
[null,null,"Cluster_264","-","-","unknown genus","unknown species",{"v":0.000195345854738592,"d":"1.95E-04"},{"v":5.82483141725476e-05,"d":"5.82E-05"},{"v":0.00131980832682691,"d":"1.32E-03"},{"v":0.027476009713033,"d":"2.75E-02"}]
[null,null,"Cluster_302","-","-","unknown genus","unknown species",{"v":0.000155721278799075,"d":"1.56E-04"},{"v":0.00039953669532598,"d":"4.00E-04"},{"v":0.00259359142671463,"d":"2.59E-03"},{"v":0.0416946765724071,"d":"4.17E-02"}]
[null,null,"Cluster_358","-","-","CAG-352","unknown species",{"v":1.01373953943203E-4,"d":"1.01E-04"},{"v":0.000304693086965647,"d":"3.05E-04"},{"v":3.25802713259766E-3,"d":"3.26E-03"},{"v":0.0434611577261115,"d":"4.35E-02"}]
[null,null,"Cluster_371","-","-","[Eubacterium] coprostanoligenes group","unknown species",{"v":0.000235615437458748,"d":"2.36E-04"},{"v":7.36593321894001E-5,"d":"7.37E-05"},{"v":2.12944442861865E-3,"d":"2.13E-03"},{"v":0.0383364945034718,"d":"3.83E-02"}]
[null,null,"Cluster_106","-","Lachnospiraceae","Lachnospiraceae UCG-008","unknown species",{"v":2.36656716827613E-3,"d":"2.37E-03"},{"v":0.000220157928730714,"d":"2.20E-04"},{"v":2.71054538018504e-05,"d":"2.71E-05"},{"v":5.20514100074616E-3,"d":"5.21E-03"}]
[null,null,"Cluster_535","-","-","Lachnospiraceae ND3007 group","unknown species",{"v":9.49944981285599e-05,"d":"9.50E-05"},{"v":3.05217058863551E-5,"d":"3.05E-05"},{"v":0.000778707388690091,"d":"7.79E-04"},{"v":0.0198137768900034,"d":"1.98E-02"}]
[null,null,"Cluster_25","-","-","Eisenbergiella","unknown species",{"v":0.0305586584097718,"d":"3.06E-02"},{"v":7.0030233009907E-3,"d":"7.00E-03"},{"v":0.00101425083551718,"d":"1.01E-03"},{"v":0.0232263441333434,"d":"2.32E-02"}]
[null,null,"Cluster_607","-","-","Eisenbergiella","unknown species",{"v":9.4016673163352e-05,"d":"9.40E-05"},{"v":2.35829202310103E-4,"d":"2.36E-04"},{"v":0.00291316517536469,"d":"2.91E-03"},{"v":0.0416946765724071,"d":"4.17E-02"}]
[null,null,"Cluster_49","-","-","[Ruminococcus] torques group","unknown species",{"v":0.00881962632686182,"d":"8.82E-03"},{"v":0.0011018368959215,"d":"1.10E-03"},{"v":2.04142477924068E-5,"d":"2.04E-05"},{"v":5.20514100074616E-3,"d":"5.21E-03"}]
[null,null,"Cluster_96","-","-","-","unknown species",{"v":0.000779380890050021,"d":"7.79E-04"},{"v":5.88701922791785e-05,"d":"5.89E-05"},{"v":0.000442474068724684,"d":"4.42E-04"},{"v":0.0144974148933679,"d":"1.45E-02"}]
[null,null,"Cluster_507","-","-","-","unknown species",{"v":0.000409400065782551,"d":"4.09E-04"},{"v":8.61465484101954e-05,"d":"8.61E-05"},{"v":4.43152420321291E-4,"d":"4.43E-04"},{"v":0.0144974148933679,"d":"1.45E-02"}]
[null,null,"Cluster_139","-","-","Tyzzerella 3","unknown species",{"v":0.000127669272044598,"d":"1.28E-04"},{"v":0.00117320786752994,"d":"1.17E-03"},{"v":0.00210396807164825,"d":"2.10E-03"},{"v":0.0383364945034718,"d":"3.83E-02"}]
[null,null,"Cluster_60","-","-","Anaerostipes","unknown species",{"v":1.41739880374776E-3,"d":"1.42E-03"},{"v":0.00495135147968084,"d":"4.95E-03"},{"v":1.21277226427709E-4,"d":"1.21E-04"},{"v":0.00793290192792883,"d":"7.93E-03"}]
[null,null,"Cluster_22","-","-","unknown genus","unknown species",{"v":0.015634933444057,"d":"1.56E-02"},{"v":0.00443505999354207,"d":"4.44E-03"},{"v":0.000772987054615024,"d":"7.73E-04"},{"v":0.0198137768900034,"d":"1.98E-02"}]
[null,null,"Cluster_481","-","-","Lachnoclostridium","unknown species",{"v":0.000239454624315538,"d":"2.39E-04"},{"v":7.36993452240097e-05,"d":"7.37E-05"},{"v":0.00330365097452329,"d":"3.30E-03"},{"v":0.0434611577261115,"d":"4.35E-02"}]
[null,null,"Cluster_105","-","-","Blautia","unknown species",{"v":0.000630819846834526,"d":"6.31E-04"},{"v":0.00170227652573754,"d":"1.70E-03"},{"v":1.88577112578488E-4,"d":"1.89E-04"},{"v":0.00793290192792883,"d":"7.93E-03"}]
[null,null,"Cluster_484","-","-","unknown genus","unknown species",{"v":1.00261634988911E-4,"d":"1.00E-04"},{"v":2.04836378089602e-05,"d":"2.05E-05"},{"v":3.32126751182075E-3,"d":"3.32E-03"},{"v":0.0434611577261115,"d":"4.35E-02"}]
[null,null,"Cluster_77","-","-","unknown genus","unknown species",{"v":0.00564869686187616,"d":"5.65E-03"},{"v":0.000135765986180798,"d":"1.36E-04"},{"v":3.40948100485556E-5,"d":"3.41E-05"},{"v":5.20514100074616E-3,"d":"5.21E-03"}]
[null,null,"Cluster_94","-","-","unknown genus","unknown species",{"v":0.00335678801687529,"d":"3.36E-03"},{"v":0.000480579553178156,"d":"4.81E-04"},{"v":6.76271798081426E-5,"d":"6.76E-05"},{"v":0.00611459700426351,"d":"6.11E-03"}]
[null,null,"Cluster_71","-","Clostridiales vadinBB60 group","unknown genus","unknown species",{"v":1.911442026792E-3,"d":"1.91E-03"},{"v":0.000592194935624345,"d":"5.92E-04"},{"v":0.00289161719296328,"d":"2.89E-03"},{"v":0.0416946765724071,"d":"4.17E-02"}]
[null,null,"Cluster_103","-","-","unknown genus","unknown species",{"v":0.000994789810087026,"d":"9.95E-04"},{"v":0.00425330392543557,"d":"4.25E-03"},{"v":0.00217630754823202,"d":"2.18E-03"},{"v":0.0383364945034718,"d":"3.83E-02"}]
[null,null,"Cluster_3","Proteobacteria","unknown family","unknown genus","unknown species",{"v":0.0175100373933918,"d":"1.75E-02"},{"v":0.0953256660796304,"d":"9.53E-02"},{"v":0.000190528212242832,"d":"1.91E-04"},{"v":0.00793290192792883,"d":"7.93E-03"}]
[null,null,"Cluster_396","-","Enterobacteriaceae","Proteus","unknown species",{"v":1.29394160245445E-5,"d":"1.29E-05"},{"v":1.31731440550217E-4,"d":"1.32E-04"},{"v":0.000921554496030742,"d":"9.22E-04"},{"v":0.0222143136411621,"d":"2.22E-02"}]
[null,null,"Cluster_453","-","-","Escherichia-Shigella","unknown species",{"v":6.55726794183576e-05,"d":"6.56E-05"},{"v":0.000292075454061889,"d":"2.92E-04"},{"v":1.63940378870407E-4,"d":"1.64E-04"},{"v":0.00793290192792883,"d":"7.93E-03"}]
[null,null,"Cluster_759","-","-","-","unknown species",{"v":5.06680081505116E-5,"d":"5.07E-05"},{"v":2.13792105810166E-4,"d":"2.14E-04"},{"v":1.5173207477634E-4,"d":"1.52E-04"},{"v":0.00793290192792883,"d":"7.93E-03"}]
[null,null,"Cluster_544","-","-","-","unknown species",{"v":0.000118474536506086,"d":"1.18E-04"},{"v":0.000422015519461767,"d":"4.22E-04"},{"v":0.00261201083143844,"d":"2.61E-03"},{"v":0.0416946765724071,"d":"4.17E-02"}]
[null,null,"Cluster_711","-","-","-","Streptomyces sp.",{"v":4.09054196804726E-5,"d":"4.09E-05"},{"v":0.000186413545478137,"d":"1.86E-04"},{"v":0.00280845089051306,"d":"2.81E-03"},{"v":0.0416946765724071,"d":"4.17E-02"}]
[null,"B2-B14 (87 OTUs)",{"$nulls":5},"B2","B14"]
[null,null,"Cluster_107","Firmicutes","Ruminococcaceae","Ruminococcaceae UCG-014","unknown species",{"v":1.09307949177179E-3,"d":"1.09E-03"},{"v":0.000131650374388695,"d":"1.32E-04"},{"v":4.19187825776347e-06,"d":"4.19E-06"},{"v":9.51556364512309E-4,"d":"9.52E-04"}]
[null,null,"Cluster_17","-","-","-","unknown species",{"v":0.0255036711473213,"d":"2.55E-02"},{"v":0.00756903258279158,"d":"7.57E-03"},{"v":7.69686468007905E-4,"d":"7.70E-04"},{"v":0.0116133748408197,"d":"1.16E-02"}]
[null,null,"Cluster_39","-","-","-","unknown species",{"v":0.0135471978273401,"d":"1.35E-02"},{"v":0.0016818549645734,"d":"1.68E-03"},{"v":0.00019214344169141,"d":"1.92E-04"},{"v":0.00671024019445385,"d":"6.71E-03"}]
[null,null,"Cluster_384","-","-","-","unknown species",{"v":2.01623840554178E-4,"d":"2.02E-04"},{"v":0,"d":"0.00E+00"},{"v":2.71094743097819E-4,"d":"2.71E-04"},{"v":0.00723982431567118,"d":"7.24E-03"}]
[null,null,"Cluster_120","-","-","-","unknown species",{"v":1.3818880526892E-3,"d":"1.38E-03"},{"v":0.000103209480149089,"d":"1.03E-04"},{"v":0.00385148193994298,"d":"3.85E-03"},{"v":0.0273214500114705,"d":"2.73E-02"}]
[null,null,"Cluster_128","-","-","-","unknown species",{"v":3.10443703368549E-3,"d":"3.10E-03"},{"v":0.000158144943159121,"d":"1.58E-04"},{"v":0.00652384427850605,"d":"6.52E-03"},{"v":0.0370228162805218,"d":"3.70E-02"}]
[null,null,"Cluster_125","-","-","-","unknown species",{"v":0.00268850980446193,"d":"2.69E-03"},{"v":0.000292475854173526,"d":"2.92E-04"},{"v":0.000788834927651327,"d":"7.89E-04"},{"v":0.0116133748408197,"d":"1.16E-02"}]
[null,null,"Cluster_397","-","-","-","unknown species",{"v":0.000486555176804439,"d":"4.87E-04"},{"v":5.85920851090699e-05,"d":"5.86E-05"},{"v":0.000818563865432223,"d":"8.19E-04"},{"v":0.0116133748408197,"d":"1.16E-02"}]
[null,null,"Cluster_489","-","-","-","unknown species",{"v":0.000324264164405689,"d":"3.24E-04"},{"v":3.22448724731503e-05,"d":"3.22E-05"},{"v":4.94682694701687E-4,"d":"4.95E-04"},{"v":0.0092596244618656,"d":"9.26E-03"}]
[null,null,"Cluster_158","-","-","-","unknown species",{"v":0.00103006520769118,"d":"1.03E-03"},{"v":0.000311152508266754,"d":"3.11E-04"},{"v":0.00855348589257333,"d":"8.55E-03"},{"v":0.0456856775909211,"d":"4.57E-02"}]
[null,null,"Cluster_228","-","-","-","unknown species",{"v":0.000668610608267227,"d":"6.69E-04"},{"v":7.66377685009615e-05,"d":"7.66E-05"},{"v":0.00202580263003589,"d":"2.03E-03"},{"v":0.0189359461457175,"d":"1.89E-02"}]
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[null,null,"Cluster_313","-","-","Oscillibacter","unknown species",{"v":0.000729214642997179,"d":"7.29E-04"},{"v":9.21700151233699e-05,"d":"9.22E-05"},{"v":0.000476753909983525,"d":"4.77E-04"},{"v":0.0092596244618656,"d":"9.26E-03"}]
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[null,null,"Cluster_54","-","Lactobacillaceae","Lactobacillus","unknown species",{"v":0.00840289776480044,"d":"8.40E-03"},{"v":1.60609150332525E-3,"d":"1.61E-03"},{"v":6.3513092794978e-07,"d":"6.35E-07"},{"v":7.22461430542875e-05,"d":"7.22E-05"}]
[null,null,"Cluster_3","Proteobacteria","unknown family","unknown genus","unknown species",{"v":0.0727156370131073,"d":"7.27E-02"},{"v":0.0162168102903677,"d":"1.62E-02"},{"v":1.61513938114143E-6,"d":"1.62E-06"},{"v":9.0210377064521e-05,"d":"9.02E-05"}]
[null,null,"Cluster_422","-","Enterobacteriaceae","Escherichia-Shigella","unknown species",{"v":2.8691940321088E-4,"d":"2.87E-04"},{"v":4.51825768806352e-05,"d":"4.52E-05"},{"v":0.00168110089666464,"d":"1.68E-03"},{"v":0.0109609830273236,"d":"1.10E-02"}]
[null,null,"Cluster_544","-","-","-","unknown species",{"v":3.29074650640602E-4,"d":"3.29E-04"},{"v":8.30221642877084e-05,"d":"8.30E-05"},{"v":0.000256968975627631,"d":"2.57E-04"},{"v":2.78383056929934E-3,"d":"2.78E-03"}]
[null,null,"Cluster_453","-","-","-","unknown species",{"v":3.11720904058089E-4,"d":"3.12E-04"},{"v":8.58928959860107e-05,"d":"8.59E-05"},{"v":0.000963488400563088,"d":"9.63E-04"},{"v":0.00782834325457509,"d":"7.83E-03"}]
[null,"B15-B19 (2 OTUs)",{"$nulls":5},"B15","B19"]
[null,null,"Cluster_299","Firmicutes","Lachnospiraceae","Eisenbergiella","unknown species",{"v":0.000334581175384986,"d":"3.35E-04"},{"v":5.6159447458088E-5,"d":"5.62E-05"},{"v":7.43740382048037e-05,"d":"7.44E-05"},{"v":0.0331446289219529,"d":"3.31E-02"}]
[null,null,"Cluster_438","-","-","unknown genus","unknown species",{"v":2.59115391884614e-05,"d":"2.59E-05"},{"v":0.000223588697694504,"d":"2.24E-04"},{"v":1.44421041054261E-4,"d":"1.44E-04"},{"v":0.0331446289219529,"d":"3.31E-02"}]
[null,"B15-B21 (2 OTUs)",{"$nulls":5},"B15","B21"]
[null,null,"Cluster_177","Firmicutes","Lachnospiraceae","Eisenbergiella","unknown species",{"v":1.52941085449685E-4,"d":"1.53E-04"},{"v":1.81787488174852E-3,"d":"1.82E-03"},{"v":1.5321993658726e-05,"d":"1.53E-05"},{"v":0.0070634390766727,"d":"7.06E-03"}]
[null,null,"Cluster_192","-","-","unknown genus","unknown species",{"v":0.000726186595160498,"d":"7.26E-04"},{"v":2.03664835508312E-4,"d":"2.04E-04"},{"v":1.12267632177061E-4,"d":"1.12E-04"},{"v":0.0258776892168125,"d":"2.59E-02"}]
[null,"Animals from both vaccine status were considered. The p-value, and adjusted p-value of the difference is given, and we indicated the mean relative abundance of each OTU in each line."]
[null,"OTU taxonomy is given at the phylum, family, and genus level when available, with '-' indicating that the annotation is the same than the taxonomy of the above OTU."]

{"sheet":"Table S7","index":10,"n_rows":261,"n_cols":10,"rows_kept":261,"merged":[[2,1,3,1],[2,2,3,2],[2,3,3,3],[2,4,3,4],[2,5,3,5],[2,6,3,6],[2,7,3,7],[2,8,2,9]]}
[{"$nulls":4},"Table S8-a"]
[null,"Table S7: Association of IBV vaccination with OTU relative abundance in caecal microbiota of hens sacrified one week after an infectious challenge. "]
[null,"OTU","Phylum","Familly","Genus","Species","p-values","adjusted p-values","Mean relative abundance"]
[{"$nulls":8},"vaccinated","control"]
[null,"Cluster_549","Firmicutes","Lachnospiraceae","[Ruminococcus] gauvreauii group","unknown species",{"v":2.518195e-11,"d":"2.52E-11"},{"v":4.63929e-10,"d":"4.64E-10"},{"v":0.0001787028,"d":"1.79E-04"},{"v":0,"d":"0.00E+00"}]
[null,"Cluster_57","-","-","[Ruminococcus] torques group","unknown species",{"v":8.663818e-08,"d":"8.66E-08"},{"v":7.280647e-07,"d":"7.28E-07"},{"v":0.006307129,"d":"6.31E-03"},{"v":0.002348947,"d":"2.35E-03"}]
[null,"Cluster_212","-","-","-","unknown species",{"v":9.036404e-06,"d":"9.04E-06"},{"v":4.918679e-05,"d":"4.92E-05"},{"v":4.449031E-4,"d":"4.45E-04"},{"v":1.878362E-4,"d":"1.88E-04"}]
[null,"Cluster_541","-","-","-","unknown species",{"v":7.187733e-05,"d":"7.19E-05"},{"v":0.0003101734,"d":"3.10E-04"},{"v":0.000270979,"d":"2.71E-04"},{"v":8.624778e-05,"d":"8.62E-05"}]
[null,"Cluster_462","-","-","-","unknown species",{"v":0.0003719721,"d":"3.72E-04"},{"v":0.001275992,"d":"1.28E-03"},{"v":0.0001772588,"d":"1.77E-04"},{"v":4.449344e-05,"d":"4.45E-05"}]
[null,"Cluster_11","-","-","-","unknown species",{"v":0.00673852,"d":"6.74E-03"},{"v":0.01572178,"d":"1.57E-02"},{"v":0.02785914,"d":"2.79E-02"},{"v":0.02010175,"d":"2.01E-02"}]
[null,"Cluster_280","-","-","-","unknown species",{"v":0.003109632,"d":"3.11E-03"},{"v":8.321307E-3,"d":"8.32E-03"},{"v":3.225538E-4,"d":"3.23E-04"},{"v":0.0001675621,"d":"1.68E-04"}]
[null,"Cluster_225","-","-","-","unknown species",{"v":0.01189628,"d":"1.19E-02"},{"v":0.02476005,"d":"2.48E-02"},{"v":0.0001743635,"d":"1.74E-04"},{"v":4.700199E-4,"d":"4.70E-04"}]
[null,"Cluster_231","-","-","-","unknown species",{"v":0.01828148,"d":"1.83E-02"},{"v":0.03574216,"d":"3.57E-02"},{"v":2.207174E-4,"d":"2.21E-04"},{"v":0.0003942512,"d":"3.94E-04"}]
[null,"Cluster_82","-","-","-","unknown species",{"v":0.0002928886,"d":"2.93E-04"},{"v":0.001054839,"d":"1.05E-03"},{"v":0.0009716048,"d":"9.72E-04"},{"v":0.00335613,"d":"3.36E-03"}]
[null,"Cluster_350","-","-","-","unknown species",{"v":0.0035054,"d":"3.51E-03"},{"v":0.009225751,"d":"9.23E-03"},{"v":0.0001386883,"d":"1.39E-04"},{"v":0.0003093432,"d":"3.09E-04"}]
[null,"Cluster_818","-","-","Agathobacter","unknown species",{"v":5.626379e-05,"d":"5.63E-05"},{"v":2.518725E-4,"d":"2.52E-04"},{"v":4.125364e-05,"d":"4.13E-05"},{"v":0.0002490954,"d":"2.49E-04"}]
[null,"Cluster_196","-","-","-","unknown species",{"v":0.0004371579,"d":"4.37E-04"},{"v":1.454157E-3,"d":"1.45E-03"},{"v":0.0007399446,"d":"7.40E-04"},{"v":0.0002055412,"d":"2.06E-04"}]
[null,"Cluster_348","-","-","Anaerostipes","unknown species",{"v":2.28607E-4,"d":"2.29E-04"},{"v":0.0008760219,"d":"8.76E-04"},{"v":0.000262093,"d":"2.62E-04"},{"v":8.697257e-05,"d":"8.70E-05"}]
[null,"Cluster_60","-","-","-","unknown species",{"v":0.01442766,"d":"1.4E-02"},{"v":0.02940786,"d":"2.94E-02"},{"v":0.004169962,"d":"4.17E-03"},{"v":0.003371079,"d":"3.37E-03"}]
[null,"Cluster_155","-","-","ASF356","unknown species",{"v":0.01614037,"d":"1.6E-02"},{"v":0.03234827,"d":"3.23E-02"},{"v":0.000445884,"d":"4.46E-04"},{"v":0.0005958591,"d":"5.96E-04"}]
[null,"Cluster_64","-","-","Blautia","unknown species",{"v":1.568283E-5,"d":"1.57E-05"},{"v":7.991567e-05,"d":"7.99E-05"},{"v":4.609882E-3,"d":"4.61E-03"},{"v":2.396114E-3,"d":"2.40E-03"}]
[null,"Cluster_205","-","-","-","unknown species",{"v":2.170457e-14,"d":"2.17E-14"},{"v":8.663742e-13,"d":"8.66E-13"},{"v":5.395411E-5,"d":"5.40E-05"},{"v":0.0007582255,"d":"7.58E-04"}]
[null,"Cluster_177","-","-","Eisenbergiella","unknown species",{"v":8.848372e-07,"d":"8.85E-07"},{"v":6.622454e-06,"d":"6.62E-06"},{"v":2.354584E-4,"d":"2.35E-04"},{"v":0.000890165,"d":"8.90E-04"}]
[null,"Cluster_25","-","-","-","unknown species",{"v":3.275254e-12,"d":"3.28E-12"},{"v":6.821073e-11,"d":"6.82E-11"},{"v":0.02125092,"d":"2.13E-02"},{"v":0.003965493,"d":"3.97E-03"}]
[null,"Cluster_157","-","-","-","unknown species",{"v":2.721042E-7,"d":"2.72E-07"},{"v":2.136687e-06,"d":"2.14E-06"},{"v":0.001049397,"d":"1.05E-03"},{"v":9.141437e-05,"d":"9.14E-05"}]
[null,"Cluster_104","-","-","-","unknown species",{"v":3.690365E-9,"d":"3.69E-09"},{"v":4.651802E-8,"d":"4.65E-08"},{"v":0.003383823,"d":"3.38E-03"},{"v":1.564953E-3,"d":"1.56E-03"}]
[null,"Cluster_1","-","-","-","unknown species",{"v":2.505451e-06,"d":"2.51E-06"},{"v":1.690297e-05,"d":"1.69E-05"},{"v":0.1095504,"d":"1.10E-01"},{"v":0.04603546,"d":"4.60E-02"}]
[null,"Cluster_590","-","-","-","unknown species",{"v":2.851328e-08,"d":"2.85E-08"},{"v":2.945272e-07,"d":"2.95E-07"},{"v":0.0001805812,"d":"1.81E-04"},{"v":5.271841e-05,"d":"5.27E-05"}]
[null,"Cluster_454","-","-","-","unknown species",{"v":3.314745e-07,"d":"3.31E-07"},{"v":2.560908e-06,"d":"2.56E-06"},{"v":1.636307E-4,"d":"1.64E-04"},{"v":4.437085e-05,"d":"4.44E-05"}]
[null,"Cluster_502","-","-","-","unknown species",{"v":1.628422e-07,"d":"1.63E-07"},{"v":1.322058e-06,"d":"1.32E-06"},{"v":0.0001724899,"d":"1.72E-04"},{"v":6.125003E-5,"d":"6.13E-05"}]
[null,"Cluster_232","-","-","-","unknown species",{"v":3.673145e-06,"d":"3.67E-06"},{"v":2.377617e-05,"d":"2.38E-05"},{"v":0.000721441,"d":"7.21E-04"},{"v":0.0003896713,"d":"3.90E-04"}]
[null,"Cluster_333","-","-","-","unknown species",{"v":9.239719e-06,"d":"9.24E-06"},{"v":4.972838e-05,"d":"4.97E-05"},{"v":0.0002450216,"d":"2.45E-04"},{"v":0.0001268845,"d":"1.27E-04"}]
[null,"Cluster_269","-","-","-","unknown species",{"v":0.0002607581,"d":"2.61E-04"},{"v":9.682413E-4,"d":"9.68E-04"},{"v":0.0002750332,"d":"2.75E-04"},{"v":0.0001570269,"d":"1.57E-04"}]
[null,"Cluster_299","-","-","-","unknown species",{"v":0.0006375201,"d":"6.38E-04"},{"v":2.063325E-3,"d":"2.06E-03"},{"v":0.0002625151,"d":"2.63E-04"},{"v":0.0001335387,"d":"1.34E-04"}]
[null,"Cluster_607","-","-","-","unknown species",{"v":0.01136061,"d":"1.14E-02"},{"v":0.02386724,"d":"2.39E-02"},{"v":0.0002576152,"d":"2.58E-04"},{"v":1.520405E-4,"d":"1.52E-04"}]
[null,"Cluster_403","-","-","-","unknown species",{"v":0.01982792,"d":"1.98E-02"},{"v":0.0379903,"d":"3.80E-02"},{"v":0.00019446,"d":"1.94E-04"},{"v":1.055017E-4,"d":"1.06E-04"}]
[null,"Cluster_51","-","-","GCA-900066575","unknown species",{"v":0.003755458,"d":"3.76E-03"},{"v":0.009776438,"d":"9.78E-03"},{"v":0.005328885,"d":"5.33E-03"},{"v":0.004385009,"d":"4.39E-03"}]
[null,"Cluster_80","-","-","-","unknown species",{"v":0.006761348,"d":"6.76E-03"},{"v":0.01572178,"d":"1.57E-02"},{"v":2.634422E-3,"d":"2.63E-03"},{"v":0.001896084,"d":"1.90E-03"}]
[null,"Cluster_392","-","-","-","unknown species",{"v":2.358551E-3,"d":"2.36E-03"},{"v":0.006492793,"d":"6.49E-03"},{"v":2.051892E-4,"d":"2.05E-04"},{"v":1.148176E-4,"d":"1.15E-04"}]
[null,"Cluster_256","-","-","-","unknown species",{"v":0.005409547,"d":"5.41E-03"},{"v":0.01302902,"d":"1.30E-02"},{"v":0.00034526,"d":"3.45E-04"},{"v":0.0002268342,"d":"2.27E-04"}]
[null,"Cluster_219","-","-","Fusicatenibacter","unknown species",{"v":1.382378e-06,"d":"1.38E-06"},{"v":1.018706E-5,"d":"1.02E-05"},{"v":0.0009095545,"d":"9.10E-04"},{"v":2.265193E-4,"d":"2.27E-04"}]
[null,"Cluster_41","-","-","-","unknown species",{"v":1.188964E-3,"d":"1.19E-03"},{"v":3.55946E-3,"d":"3.56E-03"},{"v":0.009798723,"d":"9.80E-03"},{"v":0.002433795,"d":"2.43E-03"}]
[null,"Cluster_434","-","-","-","unknown species",{"v":6.832555e-08,"d":"6.83E-08"},{"v":5.844274e-07,"d":"5.84E-07"},{"v":0.0002537363,"d":"2.54E-04"},{"v":7.751904e-05,"d":"7.75E-05"}]
[null,"Cluster_40","-","-","-","unknown species",{"v":1.836036E-4,"d":"1.84E-04"},{"v":7.263851E-4,"d":"7.26E-04"},{"v":0.004561444,"d":"4.56E-03"},{"v":0.01127014,"d":"1.13E-02"}]
[null,"Cluster_175","-","-","-","unknown species",{"v":4.793517e-05,"d":"4.79E-05"},{"v":0.0002186757,"d":"2.19E-04"},{"v":3.875269E-4,"d":"3.88E-04"},{"v":0.0009438897,"d":"9.44E-04"}]
[null,"Cluster_161","-","-","Lachnoclostridium","unknown species",{"v":1.062622E-7,"d":"1.06E-07"},{"v":8.775788e-07,"d":"8.78E-07"},{"v":0.000113184,"d":"1.13E-04"},{"v":0.001199251,"d":"1.20E-03"}]
[null,"Cluster_580","-","-","-","unknown species",{"v":6.471625e-09,"d":"6.47E-09"},{"v":7.380735e-08,"d":"7.38E-08"},{"v":2.083531e-05,"d":"2.08E-05"},{"v":1.969753E-4,"d":"1.97E-04"}]
[null,"Cluster_63","-","-","-","unknown species",{"v":0.00782936,"d":"7.83E-03"},{"v":0.01768992,"d":"1.77E-02"},{"v":4.866174E-3,"d":"4.87E-03"},{"v":0.001701182,"d":"1.70E-03"}]
[null,"Cluster_445","-","-","-","unknown species",{"v":1.577094E-3,"d":"1.58E-03"},{"v":0.004523522,"d":"4.52E-03"},{"v":0.000188334,"d":"1.88E-04"},{"v":4.062432e-05,"d":"4.06E-05"}]
[null,"Cluster_516","-","-","-","unknown species",{"v":0.0003909005,"d":"3.91E-04"},{"v":1.327029E-3,"d":"1.33E-03"},{"v":0.0001343848,"d":"1.34E-04"},{"v":6.286024e-05,"d":"6.29E-05"}]
[null,"Cluster_459","-","-","-","unknown species",{"v":0.005440091,"d":"5.44E-03"},{"v":0.01302902,"d":"1.30E-02"},{"v":0.0001717007,"d":"1.72E-04"},{"v":8.690587e-05,"d":"8.69E-05"}]
[null,"Cluster_485","-","-","-","unknown species",{"v":0.005251419,"d":"5.25E-03"},{"v":0.01283382,"d":"1.28E-02"},{"v":7.251816e-05,"d":"7.25E-05"},{"v":0.0001604044,"d":"1.60E-04"}]
[null,"Cluster_794","-","-","-","unknown species",{"v":0.007223288,"d":"7.22E-03"},{"v":0.0166344,"d":"1.66E-02"},{"v":6.519383e-05,"d":"6.52E-05"},{"v":0.0001325331,"d":"1.33E-04"}]
[null,"Cluster_13","-","-","-","unknown species",{"v":0.0001850083,"d":"1.85E-04"},{"v":7.263851E-4,"d":"7.26E-04"},{"v":0.02302461,"d":"2.30E-02"},{"v":0.01822754,"d":"1.82E-02"}]
[null,"Cluster_95","-","-","-","unknown species",{"v":0.007721729,"d":"7.72E-03"},{"v":0.0176129,"d":"1.76E-02"},{"v":0.001061594,"d":"1.06E-03"},{"v":0.002025351,"d":"2.03E-03"}]
[null,"Cluster_481","-","-","-","unknown species",{"v":7.292815e-06,"d":"7.29E-06"},{"v":4.109716e-05,"d":"4.11E-05"},{"v":0.000206989,"d":"2.07E-04"},{"v":2.889396e-05,"d":"2.89E-05"}]
[null,"Cluster_222","-","-","Lachnospiraceae FCS020 group","unknown species",{"v":0.01396749,"d":"1.40E-02"},{"v":0.02859156,"d":"2.86E-02"},{"v":0.0001592401,"d":"1.59E-04"},{"v":0.0005105052,"d":"5.11E-04"}]
[null,"Cluster_215","-","-","-","unknown species",{"v":0.00642811,"d":"6.43E-03"},{"v":0.01516781,"d":"1.52E-02"},{"v":0.0003800496,"d":"3.80E-04"},{"v":0.0002320278,"d":"2.32E-04"}]
[null,"Cluster_42","-","-","Lachnospiraceae FE2018 group","unknown species",{"v":0.004536134,"d":"4.54E-03"},{"v":0.01137596,"d":"1.14E-02"},{"v":0.004735415,"d":"4.74E-03"},{"v":0.008542527,"d":"8.54E-03"}]
[null,"Cluster_461","-","-","-","unknown species",{"v":0.008104197,"d":"8.10E-03"},{"v":0.0180554,"d":"1.81E-02"},{"v":0.0001335031,"d":"1.34E-04"},{"v":8.242133e-05,"d":"8.24E-05"}]
[null,"Cluster_543","-","-","Lachnospiraceae NC2004 group","unknown species",{"v":0.01187442,"d":"1.19E-02"},{"v":0.02476005,"d":"2.48E-02"},{"v":0.0001221415,"d":"1.22E-04"},{"v":8.244218e-05,"d":"8.24E-05"}]
[null,"Cluster_535","-","-","Lachnospiraceae ND3007 group","unknown species",{"v":0.0005500831,"d":"5.50E-04"},{"v":0.001792448,"d":"1.79E-03"},{"v":2.503076E-4,"d":"2.50E-04"},{"v":7.585649e-05,"d":"7.59E-05"}]
[null,"Cluster_683","-","-","Lachnospiraceae NK4A136 group","unknown species",{"v":1.710588e-06,"d":"1.71E-06"},{"v":1.204958e-05,"d":"1.20E-05"},{"v":0.0001563688,"d":"1.56E-04"},{"v":2.150696E-5,"d":"2.15E-05"}]
[null,"Cluster_480","-","-","-","unknown species",{"v":1.843521E-5,"d":"1.84E-05"},{"v":9.1984e-05,"d":"9.20E-05"},{"v":0.000265032,"d":"2.65E-04"},{"v":5.593221E-5,"d":"5.59E-05"}]
[null,"Cluster_520","-","-","-","unknown species",{"v":0.0008206444,"d":"8.21E-04"},{"v":0.002620591,"d":"2.62E-03"},{"v":0.0001810951,"d":"1.81E-04"},{"v":8.190454e-05,"d":"8.19E-05"}]
[null,"Cluster_402","-","-","Lachnospiraceae UCG-008","unknown species",{"v":1.163175E-4,"d":"1.16E-04"},{"v":0.0004844878,"d":"4.84E-04"},{"v":0.0002542301,"d":"2.54E-04"},{"v":1.363751E-4,"d":"1.36E-04"}]
[null,"Cluster_317","-","-","-","unknown species",{"v":1.975109e-09,"d":"1.98E-09"},{"v":2.790897e-08,"d":"2.79E-08"},{"v":0.0003323721,"d":"3.32E-04"},{"v":4.811851e-05,"d":"4.81E-05"}]
[null,"Cluster_106","-","-","-","unknown species",{"v":5.204044E-6,"d":"5.20E-06"},{"v":3.155363e-05,"d":"3.16E-05"},{"v":1.644104E-3,"d":"1.64E-03"},{"v":0.0008723056,"d":"8.72E-04"}]
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[null,"Cluster_450","-","-","unknown genus","unknown species",{"v":0.0001649056,"d":"1.65E-04"},{"v":0.0006694048,"d":"6.69E-04"},{"v":0.0001483087,"d":"1.48E-04"},{"v":9.147122e-05,"d":"9.15E-05"}]
[null,"Cluster_70","-","-","unknown genus","unknown species",{"v":0.02380635,"d":"2.38E-02"},{"v":0.04489466,"d":"4.49E-02"},{"v":0.002248794,"d":"2.25E-03"},{"v":0.004041119,"d":"4.04E-03"}]
[null,"Cluster_76","-","-","unknown genus","unknown species",{"v":0.004383187,"d":"4.38E-03"},{"v":0.01105024,"d":"1.11E-02"},{"v":0.002989505,"d":"2.99E-03"},{"v":0.00180863,"d":"1.81E-03"}]
[null,"Cluster_72","-","-","unknown genus","unknown species",{"v":1.064246E-4,"d":"1.06E-04"},{"v":0.00044717,"d":"4.47E-04"},{"v":0.003062914,"d":"3.06E-03"},{"v":0.002063378,"d":"2.06E-03"}]
[null,"Cluster_135","-","-","unknown genus","unknown species",{"v":0.01758769,"d":"1.76E-02"},{"v":0.03452665,"d":"3.45E-02"},{"v":0.0009902802,"d":"9.90E-04"},{"v":0.0006488528,"d":"6.49E-04"}]
[null,"Cluster_184","-","Clostridiales vadinBB60 group","unknown genus","unknown species",{"v":7.451088e-10,"d":"7.45E-10"},{"v":1.18969E-8,"d":"1.19E-08"},{"v":0.0001509796,"d":"1.51E-04"},{"v":0.0007779109,"d":"7.78E-04"}]
[null,"Cluster_71","-","-","unknown genus","unknown species",{"v":0.001135438,"d":"1.14E-03"},{"v":3.458947E-3,"d":"3.46E-03"},{"v":1.231621E-3,"d":"1.23E-03"},{"v":5.8820061E-3,"d":"5.88E-03"}]
[null,"Cluster_103","-","-","unknown genus","unknown species",{"v":1.34818E-3,"d":"1.35E-03"},{"v":0.004011046,"d":"4.01E-03"},{"v":0.0006425234,"d":"6.43E-04"},{"v":0.0021807351,"d":"2.18E-03"}]
[null,"Cluster_121","-","-","unknown genus","unknown species",{"v":0.0009159413,"d":"9.16E-04"},{"v":0.002905536,"d":"2.91E-03"},{"v":0.0006421351,"d":"6.42E-04"},{"v":0.0016943736,"d":"1.69E-03"}]
[null,"Cluster_26","-","-","unknown genus","unknown species",{"v":0.00427568,"d":"4.28E-03"},{"v":0.01089389,"d":"1.09E-02"},{"v":0.006201909,"d":"6.20E-03"},0.0200922131]
[null,"Cluster_292","-","-","unknown genus","unknown species",{"v":0.0002575784,"d":"2.58E-04"},{"v":0.0009639066,"d":"9.64E-04"},{"v":9.866663e-05,"d":"9.87E-05"},{"v":0.0003862841,"d":"3.86E-04"}]
[null,"Cluster_261","-","-","unknown genus","unknown species",{"v":2.277804E-3,"d":"2.28E-03"},{"v":0.006343419,"d":"6.34E-03"},{"v":0.0001859246,"d":"1.86E-04"},{"v":0.0003366196,"d":"3.37E-04"}]
[null,"Cluster_277","-","-","unknown genus","unknown species",{"v":0.00141251,"d":"1.41E-03"},{"v":0.004150872,"d":"4.15E-03"},{"v":6.430163e-05,"d":"6.43E-05"},{"v":0.0003462407,"d":"3.46E-04"}]
[null,"Cluster_92","-","-","unknown genus","unknown species",{"v":0.009662498,"d":"9.66E-03"},{"v":0.02103789,"d":"2.10E-02"},{"v":1.882007E-3,"d":"1.88E-03"},0.0010355525]
[null,"Cluster_479","-","-","unknown genus","unknown species",{"v":1.140947E-3,"d":"1.14E-03"},{"v":3.458947E-3,"d":"3.46E-03"},{"v":5.84883E-5,"d":"5.85E-05"},{"v":0.0001794521,"d":"1.79E-04"}]
[null,"Cluster_226","-","-","unknown genus","unknown species",{"v":0.01860285,"d":"1.86E-02"},{"v":0.03617396,"d":"3.62E-02"},{"v":0.0001794933,"d":"1.79E-04"},0.000479062]
[null,"Cluster_326","-","-","unknown genus","unknown species",{"v":0.01664533,"d":"1.66E-02"},{"v":0.03294674,"d":"3.29E-02"},{"v":0.0002145388,"d":"2.15E-04"},0.000522177]
[null,"Cluster_356","-","Family XIII","Family XIII AD3011 group","unknown species",{"v":2.929762E-5,"d":"2.93E-05"},{"v":1.417531E-4,"d":"1.42E-04"},{"v":7.114329E-5,"d":"7.11E-05"},{"v":0.0002949399,"d":"2.95E-04"}]
[null,"Cluster_615","-","Defluviitaleaceae","Defluviitaleaceae UCG-011","unknown species",{"v":3.756994e-13,"d":"3.76E-13"},{"v":9.997778e-12,"d":"1.00E-11"},{"v":1.273636e-05,"d":"1.27E-05"},{"v":2.309678E-4,"d":"2.31E-04"}]
[null,"Cluster_309","-","Lactobacillaceae","Lactobacillus","unknown species",{"v":1.981012e-09,"d":"1.98E-09"},{"v":2.790897e-08,"d":"2.79E-08"},{"v":0.0003427403,"d":"3.43E-04"},{"v":1.446896E-5,"d":"1.45E-05"}]
[null,"Cluster_54","-","-","-","unknown species",{"v":1.677214E-3,"d":"1.68E-03"},{"v":0.004782058,"d":"4.78E-03"},{"v":0.004044567,"d":"4.04E-03"},{"v":3.314469E-3,"d":"3.31E-03"}]
[null,"Cluster_195","Actinobacteria","Eggerthellaceae","CHKCI002","Coriobacteriaceae bacterium CHKCI002",{"v":0.02436944,"d":"2.44E-02"},{"v":0.04577631,"d":"4.58E-02"},{"v":0.000517205,"d":"5.17E-04"},{"v":0.0004358759,"d":"4.36E-04"}]
[null,"Cluster_297","Fibrobacteres","Fibrobacteraceae","Fibrobacter","unknown species",{"v":8.414677e-06,"d":"8.41E-06"},{"v":4.632908e-05,"d":"4.63E-05"},{"v":0.0004853892,"d":"4.85E-04"},{"v":0.0002142354,"d":"2.14E-04"}]
[null,"Cluster_3","Proteobacteria","unknown family","unknown genus","unknown species",{"v":9.335344E-4,"d":"9.34E-04"},{"v":0.002941862,"d":"2.94E-03"},{"v":0.0558745,"d":"5.59E-02"},{"v":0.03557675,"d":"3.56E-02"}]
[null,"Cluster_422","-","Enterobacteriaceae","Escherichia-Shigella","unknown species",{"v":4.724252e-06,"d":"4.72E-06"},{"v":2.901175e-05,"d":"2.90E-05"},{"v":0.0001965955,"d":"1.97E-04"},{"v":9.845893e-05,"d":"9.85E-05"}]
[null,"Cluster_759","-","-","-","unknown species",{"v":5.760981e-06,"d":"5.76E-06"},{"v":3.449387e-05,"d":"3.45E-05"},{"v":1.576049E-4,"d":"1.58E-04"},{"v":5.560106e-05,"d":"5.56E-05"}]
[null,"Cluster_453","-","-","-","unknown species",{"v":1.941066e-05,"d":"1.94E-05"},{"v":9.585265e-05,"d":"9.59E-05"},{"v":2.279897E-4,"d":"2.28E-04"},{"v":9.310199e-05,"d":"9.31E-05"}]
[null,"Cluster_544","-","-","-","unknown species",{"v":0.0002914059,"d":"2.91E-04"},{"v":0.001054839,"d":"1.05E-03"},{"v":0.0002631611,"d":"2.63E-04"},{"v":1.63738E-4,"d":"1.64E-04"}]
[null,"Cluster_711","-","-","-","Streptomyces sp.",{"v":6.40444E-3,"d":"6.40E-03"},{"v":0.01516781,"d":"1.52E-02"},0.0001226556,{"v":7.709985e-05,"d":"7.71E-05"}]
[null,"The p-value, and adjusted p-value of the difference is given, and we indicated the mean relative abundance of each OTU in the vaccinated and not vaccinated (control) group."]
[null,"OTU taxonomy is given at the phylum, family, and genus level when available, with '-' indicating that the annotation is the same than the taxonomy of the OTU above."]

{"sheet":"Table S8","index":11,"n_rows":94,"n_cols":13,"rows_kept":94,"merged":[[2,2,3,2],[2,3,3,3],[2,4,3,4],[2,5,3,5],[2,6,3,6],[2,7,3,7],[2,8,3,8],[2,9,3,9],[2,10,3,10],[2,11,2,12]]}
[]
[null,"Table S8: Effect of IBV vaccination on OTU relative abundance in caecal microbiota of each MHC line. "]
[null,"Line","OTU","Phylum","Class","Order","Family","Genus","Species","pvalues","adjusted p-values","Mean relative abundance"]
[null,"(OTU number)",{"$nulls":9},"vaccinated","control"]
[null,"B2-line (39 OTUs)","Cluster_25","Firmicutes","Clostridia","Clostridiales","Lachnospiraceae","Eisenbergiella","unknown species",{"v":2.186435E-5,"d":"2.19E-05"},{"v":0.002798637,"d":"2.80E-03"},{"v":0.06005,"d":"6.01E-02"},{"v":2.681793E-3,"d":"2.68E-03"}]
[null,null,"Cluster_157","-","-","-","-","-","unknown species",{"v":0.000791863,"d":"7.92E-04"},{"v":0.0161171,"d":"1.61E-02"},{"v":0.002416351,"d":"2.42E-03"},{"v":0.0001000353,"d":"1.00E-04"}]
[null,null,"Cluster_480","-","-","-","-","Lachnospiraceae NK4A136 group","unknown species",{"v":0.0008927585,"d":"8.93E-04"},{"v":0.01632473,"d":"1.63E-02"},{"v":6.078069E-4,"d":"6.08E-04"},{"v":3.208296e-05,"d":"3.21E-05"}]
[null,null,"Cluster_683","-","-","-","-","-","unknown species",{"v":0.004129195,"d":"4.13E-03"},{"v":0.04285435,"d":"4.29E-02"},{"v":0.0003795298,"d":"3.80E-04"},{"v":2.776768E-5,"d":"2.78E-05"}]
[null,null,"Cluster_96","-","-","-","-","Ruminococcus torques group","unknown species",{"v":2.707924E-3,"d":"2.71E-03"},{"v":0.03607213,"d":"3.61E-02"},{"v":0.0009820129,"d":"9.82E-04"},{"v":0.0006927321,"d":"6.93E-04"}]
[null,null,"Cluster_57","-","-","-","-","-","unknown species",{"v":2.445633E-3,"d":"2.45E-03"},{"v":0.03607213,"d":"3.61E-02"},{"v":0.00862248,"d":"8.62E-03"},{"v":0.002426638,"d":"2.43E-03"}]
[null,null,"Cluster_190","-","-","-","-","unknown genus","unknown species",{"v":2.774001E-4,"d":"2.77E-04"},{"v":0.01030067,"d":"1.03E-02"},{"v":0.003064202,"d":"3.06E-03"},{"v":0.0002088554,"d":"2.09E-04"}]
[null,null,"Cluster_151","-","-","-","-","Tyzzerella 3","unknown species",{"v":2.541691E-3,"d":"2.54E-03"},{"v":0.03607213,"d":"3.61E-02"},{"v":0.0008207139,"d":"8.21E-04"},{"v":0.0002027301,"d":"2.03E-04"}]
[null,null,"Cluster_219","-","-","-","-","Fusicatenibacter","unknown species",{"v":0.003363189,"d":"3.36E-03"},{"v":0.04079689,"d":"4.08E-02"},{"v":0.001171541,"d":"1.17E-03"},{"v":2.037427E-4,"d":"2.04E-04"}]
[null,null,"Cluster_722","-","-","-","-","Anaerosporobacter","unknown species",{"v":0.00457051,"d":"4.57E-03"},{"v":0.04500194,"d":"4.50E-02"},{"v":2.316014e-05,"d":"2.32E-05"},{"v":1.901731E-4,"d":"1.90E-04"}]
[null,null,"Cluster_481","-","-","-","-","Lachnoclostridium","unknown species",{"v":0.002933715,"d":"2.93E-03"},{"v":0.03755155,"d":"3.76E-02"},{"v":0.0004517018,"d":"4.52E-04"},{"v":4.057176e-05,"d":"4.06E-05"}]
[null,null,"Cluster_77","-","-","-","-","unknown genus","unknown species",{"v":7.974608E-4,"d":"7.97E-04"},{"v":0.0161171,"d":"1.61E-02"},{"v":0.01061663,"d":"1.06E-02"},{"v":0.0008893867,"d":"8.89E-04"}]
[null,null,"Cluster_94","-","-","-","-","unknown genus","unknown species",{"v":0.0002758016,"d":"2.76E-04"},{"v":0.01030067,"d":"1.03E-02"},{"v":0.006033886,"d":"6.03E-03"},{"v":0.0008616368,"d":"8.62E-04"}]
[null,null,"Cluster_559","-","-","-","-","unknown genus","unknown species",{"v":0.002724197,"d":"2.72E-03"},{"v":0.03607213,"d":"3.61E-02"},{"v":0.0002768462,"d":"2.77E-04"},{"v":4.774706E-5,"d":"4.77E-05"}]
[null,null,"Cluster_53","-","-","-","-","unknown genus","unknown species",{"v":0.00339974,"d":"3.40E-03"},{"v":0.04079689,"d":"4.08E-02"},{"v":0.005100198,"d":"5.10E-03"},{"v":2.951852E-3,"d":"2.95E-03"}]
[null,null,"Cluster_317","-","-","-","-","Lachnospiraceae UCG-008","unknown species",{"v":0.0001825275,"d":"1.83E-04"},{"v":0.01001294,"d":"1.00E-02"},{"v":0.000575291,"d":"5.75E-04"},{"v":4.094637e-05,"d":"4.09E-05"}]
[null,null,"Cluster_106","-","-","-","-","-","unknown species",{"v":0.004093828,"d":"4.09E-03"},{"v":0.04285435,"d":"4.29E-02"},{"v":0.003260201,"d":"3.26E-03"},{"v":1.719817E-3,"d":"1.72E-03"}]
[null,null,"Cluster_247","-","-","-","-","-","unknown species",{"v":0.0002723803,"d":"2.72E-04"},{"v":0.01030067,"d":"1.03E-02"},{"v":1.08303E-4,"d":"1.08E-04"},{"v":0.001466372,"d":"1.47E-03"}]
[null,null,"Cluster_42","-","-","-","-","Lachnospiraceae FE2018 group","unknown species",{"v":0.0003818007,"d":"3.82E-04"},{"v":0.01047225,"d":"1.05E-02"},{"v":0.002305398,"d":"2.31E-03"},{"v":0.01199777,"d":"1.20E-02"}]
[null,null,"Cluster_205","-","-","-","-","Blautia","unknown species",{"v":0.0008442106,"d":"8.44E-04"},{"v":0.01620884,"d":"1.62E-02"},{"v":1.78267E-5,"d":"1.78E-05"},{"v":0.0005962537,"d":"5.96E-04"}]
[null,null,"Cluster_112","-","-","-","-","unknown genus","unknown species",{"v":0.0004908697,"d":"4.91E-04"},{"v":0.01256626,"d":"1.26E-02"},{"v":3.487406e-05,"d":"3.49E-05"},{"v":0.003125068,"d":"3.13E-03"}]
[null,null,"Cluster_198","-","-","-","unknown family","unknown genus","unknown species",{"v":2.103897E-3,"d":"2.10E-03"},{"v":0.03366235,"d":"3.37E-02"},{"v":0.0001461734,"d":"1.46E-04"},{"v":0.0005047609,"d":"5.05E-04"}]
[null,null,"Cluster_6","-","-","-","Ruminococcaceae","Faecalibacterium","unknown species",{"v":3.336999E-4,"d":"3.34E-04"},{"v":0.01030067,"d":"1.03E-02"},{"v":8.453989e-05,"d":"8.45E-05"},{"v":0.2549691,"d":"2.55E-01"}]
[null,null,"Cluster_39","-","-","-","-","Ruminococcaceae UCG-014","unknown species",{"v":2.150271e-08,"d":"2.15E-08"},{"v":8.257042e-06,"d":"8.26E-06"},{"v":0.0004395414,"d":"4.40E-04"},{"v":0.02883955,"d":"2.88E-02"}]
[null,null,"Cluster_228","-","-","-","-","-","unknown species",{"v":9.049444e-05,"d":"9.05E-05"},{"v":0.005961393,"d":"5.96E-03"},{"v":3.053724e-05,"d":"3.05E-05"},{"v":1.426236E-3,"d":"1.43E-03"}]
[null,null,"Cluster_152","-","-","-","-","-","unknown species",{"v":0.001265882,"d":"1.27E-03"},{"v":0.02113473,"d":"2.11E-02"},{"v":0.0001049675,"d":"1.05E-04"},{"v":0.003822163,"d":"3.82E-03"}]
[null,null,"Cluster_125","-","-","-","-","-","unknown species",{"v":0.0007562214,"d":"7.56E-04"},{"v":0.0161171,"d":"1.61E-02"},{"v":2.445506E-4,"d":"2.45E-04"},{"v":0.005225971,"d":"5.23E-03"}]
[null,null,"Cluster_489","-","-","-","-","-","unknown species",{"v":3.877077E-3,"d":"3.88E-03"},{"v":0.04285435,"d":"4.29E-02"},{"v":4.680654e-05,"d":"4.68E-05"},{"v":0.0006490212,"d":"6.49E-04"}]
[null,null,"Cluster_164","-","-","-","-","-","unknown species",{"v":0.002377163,"d":"2.38E-03"},{"v":0.03607213,"d":"3.61E-02"},{"v":2.138675E-3,"d":"2.14E-03"},{"v":9.137513e-05,"d":"9.14E-05"}]
[null,null,"Cluster_313","-","-","-","-","Oscillibacter","unknown species",{"v":6.874634e-05,"d":"6.87E-05"},{"v":0.005961393,"d":"5.96E-03"},{"v":1.345099E-3,"d":"1.35E-03"},{"v":0.0001290558,"d":"1.29E-04"}]
[null,null,"Cluster_204","-","-","-","-","-","unknown species",{"v":0.003672225,"d":"3.67E-03"},{"v":0.04273135,"d":"4.27E-02"},{"v":1.225365E-3,"d":"1.23E-03"},{"v":0.0001760874,"d":"1.76E-04"}]
[null,null,"Cluster_174","-","-","-","-","Ruminiclostridium 9","unknown species",{"v":9.240364e-06,"d":"9.24E-06"},{"v":0.00177415,"d":"1.77E-03"},{"v":1.626597E-3,"d":"1.63E-03"},{"v":1.21413E-4,"d":"1.21E-04"}]
[null,null,"Cluster_110","-","-","-","-","Ruminiclostridium 5","unknown species",{"v":0.004410875,"d":"4.41E-03"},{"v":0.04457305,"d":"4.46E-02"},{"v":0.002487072,"d":"2.49E-03"},{"v":0.000995417,"d":"9.95E-04"}]
[null,null,"Cluster_143","-","-","-","-","Flavonifractor","unknown species",{"v":0.0003487207,"d":"3.49E-04"},{"v":0.01030067,"d":"1.03E-02"},{"v":0.001178504,"d":"1.18E-03"},{"v":5.407697e-05,"d":"5.41E-05"}]
[null,null,"Cluster_116","-","-","-","-","unknown genus","unknown species",{"v":3.014073E-4,"d":"3.01E-04"},{"v":0.01030067,"d":"1.03E-02"},{"v":0.002357335,"d":"2.36E-03"},{"v":0.0004849684,"d":"4.85E-04"}]
[null,null,"Cluster_154","-","-","-","-","unknown genus","unknown species",{"v":0.0005531408,"d":"5.53E-04"},{"v":0.01327538,"d":"1.33E-02"},{"v":1.186432E-4,"d":"1.19E-04"},{"v":0.001127066,"d":"1.13E-03"}]
[null,null,"Cluster_137","-","-","-","-","unknown genus","unknown species",{"v":0.004080832,"d":"4.08E-03"},{"v":0.04285435,"d":"4.29E-02"},{"v":2.320472E-4,"d":"2.32E-04"},{"v":3.166098E-3,"d":"3.17E-03"}]
[null,null,"Cluster_121","-","-","-","Clostridiales vadinBB60 group","unknown genus","unknown species",{"v":0.001245918,"d":"1.25E-03"},{"v":0.02113473,"d":"2.11E-02"},{"v":1.226802E-4,"d":"1.23E-04"},{"v":0.003585779,"d":"3.59E-03"}]
[null,null,"Cluster_54","-","Bacilli","Lactobacillales","Lactobacillaceae","Lactobacillus","unknown species",{"v":9.314676e-05,"d":"9.31E-05"},{"v":0.005961393,"d":"5.96E-03"},{"v":0.00441478,"d":"4.41E-03"},{"v":0.0007748965,"d":"7.75E-04"}]
[null,"B12-line (4 OTUs)","Cluster_84","Firmicutes","Clostridia","Clostridiales","Lachnospiraceae","unknown genus","unknown species",{"v":1.621456E-4,"d":"1.62E-04"},0.0271593903,1.1804989E-3,1.121623E-4]
[null,null,"Cluster_6","-","-","-","Ruminococcaceae","Faecalibacterium","unknown species",{"v":3.721162e-07,"d":"3.72E-07"},0.0001246589,0.0001250218,0.3645580527]
[null,null,"Cluster_21","-","-","-","-","Ruminococcaceae UCG-014","unknown species",{"v":0.0005278748,"d":"5.28E-04"},0.0442095124,0.0036917694,0.0466668191]
[null,null,"Cluster_27","-","-","-","-","unknown genus","unknown species",{"v":0.0005214449,"d":"5.21E-04"},0.0442095124,0.0106887166,0.0289797487]
[null,"B14-line (5 OTUs)","Cluster_667","Firmicutes","Clostridia","Clostridiales","Lachnospiraceae","Lachnospiraceae UCG-006","unknown species",{"v":0.0006060059,"d":"6.06E-04"},0.038784381,{"v":3.771162e-05,"d":"3.77E-05"},0.0007349252]
[null,null,"Cluster_155","-","-","-","-","ASF356","unknown species",{"v":8.453861e-06,"d":"8.45E-06"},0.002705235,{"v":2.472713e-05,"d":"2.47E-05"},1.1442441E-3]
[null,null,"Cluster_62","-","-","-","-","-","unknown species",{"v":2.994602E-4,"d":"2.99E-04"},0.024537603,{"v":0.01440134,"d":"1.44E-02"},0.0081502431]
[null,null,"Cluster_25","-","-","-","-","Eisenbergiella","unknown species",{"v":0.000281304,"d":"2.81E-04"},0.024537603,{"v":0.005625322,"d":"5.63E-03"},0.0009185806]
[null,null,"Cluster_23","-","-","-","Ruminococcaceae","Negativibacillus","unknown species",{"v":0.00030672,"d":"3.07E-04"},0.024537603,{"v":0.00737238,"d":"7.37E-03"},0.0326087411]
[null,"B15-line (9 OTUs)","Cluster_151","Firmicutes","Clostridia","Clostridiales","Lachnospiraceae","Tyzzerella 3","unknown species",{"v":9.370055e-05,"d":"9.37E-05"},0.011837502,{"v":1.495295E-3,"d":"1.50E-03"},{"v":0.0004340376,"d":"4.34E-04"}]
[null,null,"Cluster_265","-","-","-","-","-","unknown species",{"v":0.0008854247,"d":"8.85E-04"},0.037286218,{"v":0.0005580287,"d":"5.58E-04"},{"v":0.0001455181,"d":"1.46E-04"}]
[null,null,"Cluster_33","-","-","-","-","unknown genus","unknown species",{"v":0.0001794873,"d":"1.79E-04"},0.013605136,{"v":0.01710435,"d":"1.71E-02"},{"v":7.494105E-3,"d":"7.49E-03"}]
[null,null,"Cluster_39","-","-","-","Ruminococcaceae","Ruminococcaceae UCG-014","unknown species",{"v":1.879208e-05,"d":"1.88E-05"},0.007122199,{"v":1.000586e-05,"d":"1.00E-05"},{"v":0.02057576,"d":"2.06E-02"}]
[null,null,"Cluster_152","-","-","-","-","-","unknown species",{"v":0.0001363159,"d":"1.36E-04"},0.012915929,{"v":5.469366e-05,"d":"5.47E-05"},{"v":0.001913776,"d":"1.91E-03"}]
[null,null,"Cluster_6","-","-","-","-","Faecalibacterium","unknown species",{"v":7.993338E-4,"d":"7.99E-04"},0.037286218,{"v":1.295927e-05,"d":"1.30E-05"},{"v":0.07083491,"d":"7.08E-02"}]
[null,null,"Cluster_66","-","-","-","-","unknown genus","unknown species",{"v":8.452371e-05,"d":"8.45E-05"},0.011837502,{"v":6.266788e-05,"d":"6.27E-05"},{"v":0.01025369,"d":"1.03E-02"}]
[null,null,"Cluster_174","-","-","-","-","Ruminiclostridium 9","unknown species",{"v":0.0008222068,"d":"8.22E-04"},0.037286218,{"v":0.001968336,"d":"1.97E-03"},{"v":9.501181e-05,"d":"9.50E-05"}]
[null,null,"Cluster_553","-","-","-","-","DTU089","unknown species",{"v":0.0003736603,"d":"3.74E-04"},0.023602878,{"v":0.0002580186,"d":"2.58E-04"},{"v":7.268729e-05,"d":"7.27E-05"}]
[null,"B19-line (22 OTUs)","Cluster_151","Firmicutes","Clostridia","Clostridiales","Lachnospiraceae","Tyzzerella 3","unknown species",{"v":0.0005705403,"d":"5.71E-04"},0.0202282484,{"v":6.693116E-4,"d":"6.69E-04"},{"v":2.260021E-4,"d":"2.26E-04"}]
[null,null,"Cluster_106","-","-","-","-","Lachnospiraceae UCG-008","unknown species",{"v":0.0002345866,"d":"2.35E-04"},0.0122760759,{"v":0.002275903,"d":"2.28E-03"},{"v":3.741374E-4,"d":"3.74E-04"}]
[null,null,"Cluster_196","-","-","-","-","Agathobacter","unknown species",{"v":0.002798552,"d":"2.80E-03"},0.0496106933,{"v":1.241577E-3,"d":"1.24E-03"},{"v":3.86694e-05,"d":"3.87E-05"}]
[null,null,"Cluster_57","-","-","-","-","Ruminococcus torques group","unknown species",{"v":0.002782291,"d":"2.78E-03"},0.0496106933,{"v":0.008252129,"d":"8.25E-03"},{"v":2.493262E-3,"d":"2.49E-03"}]
[null,null,"Cluster_537","-","-","-","-","unknown genus","unknown species",{"v":0.001724355,"d":"1.72E-03"},0.0395587263,{"v":4.415016E-4,"d":"4.42E-04"},{"v":7.985982e-05,"d":"7.99E-05"}]
[null,null,"Cluster_403","-","-","-","-","Eisenbergiella","unknown species",{"v":2.225215E-3,"d":"2.23E-03"},0.0433916974,{"v":0.0005458003,"d":"5.46E-04"},{"v":5.101384e-05,"d":"5.10E-05"}]
[null,null,"Cluster_590","-","-","-","-","-","unknown species",{"v":0.001012973,"d":"1.01E-03"},0.0263372893,{"v":2.126025E-4,"d":"2.13E-04"},{"v":2.86399E-5,"d":"2.86E-05"}]
[null,null,"Cluster_64","-","-","-","-","Blautia","unknown species",{"v":2.1180080000000002E-3,"d":"2.12E-03"},0.0433916974,{"v":0.007018357,"d":"7.02E-03"},{"v":0.0002732922,"d":"2.73E-04"}]
[null,null,"Cluster_205","-","-","-","-","-","unknown species",{"v":0.0003222927,"d":"3.22E-04"},0.0139660181,{"v":7.180903e-05,"d":"7.18E-05"},{"v":0.0008914992,"d":"8.91E-04"}]
[null,null,"Cluster_161","-","-","-","-","Lachnoclostridium","unknown species",{"v":0.0008201195,"d":"8.20E-04"},0.0246035842,{"v":1.019227E-4,"d":"1.02E-04"},{"v":7.778447E-4,"d":"7.78E-04"}]
[null,null,"Cluster_112","-","-","-","-","unknown genus","unknown species",{"v":3.538105e-07,"d":"3.54E-07"},1.379861E-4,{"v":2.449141e-05,"d":"2.45E-05"},{"v":0.003685201,"d":"3.69E-03"}]
[null,null,"Cluster_39","-","-","-","Ruminococcaceae","Ruminococcaceae UCG-014","unknown species",{"v":2.133002e-06,"d":"2.13E-06"},0.0004159354,{"v":8.670988e-05,"d":"8.67E-05"},{"v":0.01228333,"d":"1.23E-02"}]
[null,null,"Cluster_125","-","-","-","-","-","unknown species",{"v":3.174158E-5,"d":"3.17E-05"},0.003770521,{"v":4.930061e-05,"d":"4.93E-05"},{"v":0.005566711,"d":"5.57E-03"}]
[null,null,"Cluster_120","-","-","-","-","-","unknown species",{"v":0.0001859991,"d":"1.86E-04"},0.0120899387,{"v":0.0002614428,"d":"2.61E-04"},{"v":1.48431E-3,"d":"1.48E-03"}]
[null,null,"Cluster_17","-","-","-","-","-","unknown species",{"v":0.002224631,"d":"2.22E-03"},0.0433916974,{"v":2.053549E-3,"d":"2.05E-03"},{"v":0.005831918,"d":"5.83E-03"}]
[null,null,"Cluster_6","-","-","-","-","Faecalibacterium","unknown species",{"v":0.0002518169,"d":"2.52E-04"},0.0122760759,{"v":1.233401E-5,"d":"1.23E-05"},{"v":0.07556266,"d":"7.56E-02"}]
[null,null,"Cluster_148","-","-","-","-","Candidatus Soleaferrea","unknown species",{"v":0.0004141094,"d":"4.14E-04"},0.0161502666,{"v":0.0002713686,"d":"2.71E-04"},{"v":0.002529915,"d":"2.53E-03"}]
[null,null,"Cluster_137","-","-","-","-","unknown genus","unknown species",{"v":0.0009345951,"d":"9.35E-04"},0.0260351503,{"v":0.0001683114,"d":"1.68E-04"},{"v":0.003999105,"d":"4.00E-03"}]
[null,null,"Cluster_66","-","-","-","-","unknown genus","unknown species",{"v":0.0001587945,"d":"1.59E-04"},0.0120899387,{"v":0.0001367198,"d":"1.37E-04"},{"v":0.004508332,"d":"4.51E-03"}]
[null,null,"Cluster_159","-","-","-","-","Ruminiclostridium 5","unknown species",{"v":0.000782081,"d":"7.82E-04"},0.0246035842,{"v":1.552725E-3,"d":"1.55E-03"},{"v":0.0002645369,"d":"2.65E-04"}]
[null,null,"Cluster_174","-","-","-","-","Ruminiclostridium 9","unknown species",{"v":0.001722628,"d":"1.72E-03"},0.0395587263,{"v":0.0005249242,"d":"5.25E-04"},{"v":1.060192E-4,"d":"1.06E-04"}]
[null,null,"Cluster_121","-","-","-","Clostridiales vadinBB60 group","unknown genus","unknown species",{"v":3.867201e-05,"d":"3.87E-05"},0.003770521,{"v":0.0001249819,"d":"1.25E-04"},{"v":1.118181E-3,"d":"1.12E-03"}]
[null,"B21-line (9 OTUs)","Cluster_148","Firmicutes","Clostridia","Clostridiales","Ruminococcaceae","Candidatus Soleaferrea","unknown species",{"v":0.0001087652,"d":"1.09E-04"},0.013704412,{"v":1.288075E-4,"d":"1.29E-04"},{"v":0.002011249,"d":"2.01E-03"}]
[null,null,"Cluster_52","-","-","-","-","Ruminococcaceae UCG-014","unknown species",{"v":0.0002645655,"d":"2.65E-04"},0.020001152,{"v":0.0002431102,"d":"2.43E-04"},{"v":0.03894599,"d":"3.89E-02"}]
[null,null,"Cluster_125","-","-","-","-","-","unknown species",{"v":4.213496E-4,"d":"4.21E-04"},0.026545023,{"v":3.294768e-05,"d":"3.29E-05"},{"v":0.002501674,"d":"2.50E-03"}]
[null,null,"Cluster_152","-","-","-","-","-","unknown species",{"v":0.0005799072,"d":"5.80E-04"},0.029420647,{"v":3.500585E-4,"d":"3.50E-04"},{"v":0.002126492,"d":"2.13E-03"}]
[null,null,"Cluster_164","-","-","-","-","-","unknown species",{"v":0.0006226592,"d":"6.23E-04"},0.029420647,{"v":0.001907421,"d":"1.91E-03"},{"v":0.0002510253,"d":"2.51E-04"}]
[null,null,"Cluster_205","-","-","-","Lachnospiraceae","Blautia","unknown species",{"v":2.238199E-4,"d":"2.24E-04"},0.020001152,{"v":0.0001608885,"d":"1.61E-04"},{"v":0.001955121,"d":"1.96E-03"}]
[null,null,"Cluster_64","-","-","-","-","-","unknown species",{"v":3.798063e-06,"d":"3.80E-06"},1.435668E-3,{"v":0.004205196,"d":"4.21E-03"},{"v":0.0002405894,"d":"2.41E-04"}]
[null,null,"Cluster_57","-","-","-","-","Ruminococcus torques group","unknown species",{"v":8.451753e-06,"d":"8.45E-06"},0.001597381,{"v":0.008281503,"d":"8.28E-03"},{"v":0.0009805819,"d":"9.81E-04"}]
[null,null,"Cluster_537","-","-","-","-","unknown genus","unknown species",{"v":0.001172594,"d":"1.17E-03"},0.049248932,{"v":0.0004978693,"d":"4.98E-04"},{"v":2.305022E-5,"d":"2.31E-05"}]
[null,"The p-value, and adjusted p-value of the difference is given, and we indicated the mean relative abundance of each OTU in the vaccinated and not vaccinated (control) group."]
[null,"OTU taxonomy is given at the phylum, family, and genus level when available, with '-' indicating that the annotation is the same than the taxonomy of the OTU above."]

{"sheet":"Table S9","index":12,"n_rows":116,"n_cols":32,"rows_kept":116}
[]
[null,"Table S9: Associations between OTU relative abundance and the immune parameters in the low and high responders to IBV vaccination."]
[null,"Indice","OTU","Phylum","Familly","Genus","Thrombocytes","Heterophils","Monocytes","B cells","TCRϒδ+ T  cells","Frequency of TCR1+ CD8+ ϒδ T cells","Frequency of TCR1+ CD8- ϒδ T cells","Frequency of (ab) T cells","Frequency of TCR1-CD8+ (ab) T cells","Frequency of TCR1-CD4+ (ab) T cells","Frequency of TCR1-CD4+CD25+ (ab) T cells","Frequency of Thrombocytes","CD45 expression on Thrombocytes","CD45 expression on heterophils","MRC1L-B expression on Monocytes","CD45 expression on monocytes","MHCII expression on monocytes","Bu1 expression on B cells","IgM on B cells","TCRϒδ expression on TCRϒδ+ T cells","CD8 β expression on CD8 αβ+ TCR ϒδ+  T cells","CD8 β expression on CD8 αβ+ T cells","CD4 expression on CD4+ T cells","CD4 expression on CD4+ CD25+    T cells","CD25 expression on CD4+ CD25+ T cells","MHC II expression on B cells"]
[]
[null,"Spearman correlation","Cluster_677","Firmicutes","Lachnospiraceae","Lachnospiraceae UCG-008",{"v":0.0940545440809851,"d":"0.09"},{"v":0.0418272015310619,"d":"0.04"},{"v":-0.0397622824909975,"d":"-0.04"},{"v":-0.183349701594017,"d":"-0.18"},{"v":0.348442497041122,"d":"0.35"},{"v":0.477021480194405,"d":"0.48"},{"v":0.276724333308151,"d":"0.28"},{"v":-0.0599078341013825,"d":"-0.06"},{"v":0.203444889325376,"d":"0.20"},{"v":0.348492860920148,"d":"0.35"},{"v":0.197048676689079,"d":"0.20"},{"v":0.138979124172144,"d":"0.14"},{"v":0.401475661655461,"d":"0.40"},{"v":0.285840195411851,"d":"0.29"},{"v":0.157741655242229,"d":"0.16"},{"v":0.223791896451865,"d":"0.22"},{"v":0.0784417415829367,"d":"0.08"},{"v":-0.0907808919442975,"d":"-0.09"},{"v":-0.231525667033374,"d":"-0.23"},{"v":-0.0910830752184533,"d":"-0.09"},{"v":0.190199189141548,"d":"0.19"},{"v":-0.0164438065019768,"d":"-0.02"},{"v":-0.132028908866561,"d":"-0.13"},{"v":-0.281659993452696,"d":"-0.28"},{"v":-0.325526932084309,"d":"-0.33"},{"v":0.0467628616756063,"d":"0.05"}]
[null,"coefficient","Cluster_106","-","-","Lachnospiraceae UCG-008",{"v":-0.112487723804487,"d":"-0.11"},{"v":0.352622699000277,"d":"0.35"},{"v":0.342650650953136,"d":"0.34"},{"v":0.385107400972023,"d":"0.39"},{"v":0.247110372440885,"d":"0.25"},{"v":-0.12754652363325,"d":"-0.13"},{"v":0.293898416056005,"d":"0.29"},{"v":0.125531968472212,"d":"0.13"},{"v":-0.0158394399536652,"d":"-0.02"},{"v":0.204603258542973,"d":"0.20"},{"v":0.1654705245398,"d":"0.17"},{"v":-0.120344488932538,"d":"-0.12"},{"v":0.0101986855027574,"d":"0.01"},{"v":-0.27113394273627,"d":"-0.27"},{"v":0.0306719885193223,"d":"0.03"},{"v":0.204351439147843,"d":"0.20"},{"v":-0.368537684772481,"d":"-0.37"},{"v":-0.0117599657525623,"d":"-0.01"},{"v":-0.21548456958936,"d":"-0.22"},{"v":0.237339779909849,"d":"0.24"},{"v":-0.177104580594797,"d":"-0.18"},{"v":0.0741104479867039,"d":"0.07"},{"v":0.266802649140037,"d":"0.27"},{"v":0.303719372466067,"d":"0.30"},{"v":0.215330764775503,"d":"0.22"},{"v":-0.458537936591876,"d":"-0.46"}]
[null,null,"Cluster_49","-","-","[Ruminococcus] torques group",{"v":-0.280904535267306,"d":"-0.28"},{"v":0.0384528216363224,"d":"0.04"},{"v":0.107199516506761,"d":"0.11"},{"v":0.014832162373146,"d":"0.01"},{"v":0.389489058447282,"d":"0.39"},{"v":-9.74541059152376E-3,"d":"-0.01"},{"v":0.440054392989348,"d":"0.44"},{"v":-0.211805293243686,"d":"-0.21"},{"v":-0.0190123643323009,"d":"-0.02"},{"v":1.93900934249956E-3,"d":"0.00"},{"v":-0.0386542771524263,"d":"-0.04"},{"v":0.0111555992042507,"d":"0.01"},{"v":-0.0652967691571605,"d":"-0.07"},{"v":-0.333383697212359,"d":"-0.33"},{"v":-0.0447992344629511,"d":"-0.04"},{"v":0.0273224043715847,"d":"0.03"},{"v":-0.380826471254816,"d":"-0.38"},{"v":0.044395759361386,"d":"0.04"},{"v":-0.137696579001358,"d":"-0.14"},{"v":0.201732517438493,"d":"0.20"},{"v":-0.100198937322153,"d":"-0.10"},{"v":-0.0958676437259198,"d":"-0.10"},{"v":0.172874014756617,"d":"0.17"},{"v":0.276472513913022,"d":"0.28"},{"v":-0.017501447961522,"d":"-0.02"},{"v":-0.394172899196696,"d":"-0.39"}]
[null,null,"Cluster_818","-","-","Agathobacter",{"v":-0.27849057556255,"d":"-0.28"},{"v":-0.184031931115934,"d":"-0.18"},{"v":0.108359250080988,"d":"0.11"},{"v":-0.163936490361895,"d":"-0.16"},{"v":-0.106395034067436,"d":"-0.11"},{"v":-0.148273126766642,"d":"-0.15"},{"v":-0.0775865325353301,"d":"-0.08"},{"v":-0.0931743493608313,"d":"-0.09"},{"v":-0.425605318526327,"d":"-0.43"},{"v":-0.305108220771847,"d":"-0.31"},{"v":-0.199267196349259,"d":"-0.20"},{"v":0.147970939687634,"d":"0.15"},{"v":-0.304906762719175,"d":"-0.30"},{"v":-0.253132043182453,"d":"-0.25"},{"v":0.129942080080584,"d":"0.13"},{"v":-0.0766044245285538,"d":"-0.08"},{"v":0.144823157614633,"d":"0.14"},{"v":0.164465317750159,"d":"0.16"},{"v":0.0880382775119617,"d":"0.09"},{"v":0.318857732866715,"d":"0.32"},{"v":-0.086098135260725,"d":"-0.09"},{"v":0.104657458363139,"d":"0.10"},{"v":0.0204228100896309,"d":"0.02"},{"v":0.101635587573058,"d":"0.10"},{"v":0.188766195353727,"d":"0.19"},{"v":0.122209491202193,"d":"0.12"}]
[null,null,"Cluster_451","-","-","Lachnoclostridium",{"v":-0.174435295006421,"d":"-0.17"},{"v":-0.201732517438493,"d":"-0.20"},{"v":0.121956133061368,"d":"0.12"},{"v":0.0212283750094432,"d":"0.02"},{"v":-0.222381707839138,"d":"-0.22"},{"v":-0.243887084183224,"d":"-0.24"},{"v":-0.18954445871421,"d":"-0.19"},{"v":-0.087456875928584,"d":"-0.09"},{"v":-0.322555463221777,"d":"-0.32"},{"v":-0.440054392989348,"d":"-0.44"},{"v":-0.248873108206794,"d":"-0.25"},{"v":-0.0152854372843796,"d":"-0.02"},{"v":-0.266198282591725,"d":"-0.27"},{"v":-0.141799501397598,"d":"-0.14"},{"v":0.127573311854587,"d":"0.13"},{"v":0.099544206894815,"d":"0.10"},{"v":0.0965223741532573,"d":"0.10"},{"v":-0.0424819319583994,"d":"-0.04"},{"v":0.0974301507235288,"d":"0.10"},{"v":0.339125179421319,"d":"0.34"},{"v":-0.110473168643449,"d":"-0.11"},{"v":0.0629296668429402,"d":"0.06"},{"v":0.0774848278814434,"d":"0.08"},{"v":0.185414620634081,"d":"0.19"},{"v":0.193623932915313,"d":"0.19"},{"v":-0.0300420538389867,"d":"-0.03"}]
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[null,null,"Cluster_237","-","-","unknown genus",{"v":0.988686173150412,"d":"0.98869"},{"v":0.156922241530362,"d":"0.15692"},{"v":0.0892549799709626,"d":"0.08925"},{"v":0.374995369924507,"d":"0.37500"},{"v":0.97567040448196,"d":"0.97567"},{"v":0.575623750298627,"d":"0.57562"},{"v":0.835470381370163,"d":"0.83547"},{"v":0.282313803225897,"d":"0.28231"},{"v":0.839418264397392,"d":"0.83942"},{"v":0.651395373946315,"d":"0.65140"},{"v":0.659130541848421,"d":"0.65913"},{"v":0.294845314112778,"d":"0.29485"},{"v":0.170528089425152,"d":"0.17053"},{"v":0.204215508265743,"d":"0.20422"},{"v":0.153443418621315,"d":"0.15344"},{"v":0.650553727241297,"d":"0.65055"},{"v":0.286124722268202,"d":"0.28612"},{"v":0.93883785360086,"d":"0.93884"},{"v":0.265194133011798,"d":"0.26519"},{"v":0.0678478596893817,"d":"0.06785"},{"v":0.935129435910921,"d":"0.93513"},{"v":0.172271950383578,"d":"0.17227"},{"v":0.427161247524039,"d":"0.42716"},{"v":0.771577360792099,"d":"0.77158"},{"v":0.00107914679887745,"d":"0.00108"},{"v":0.856448371187109,"d":"0.85645"}]
[null,null,"Cluster_479","-","Clostridiales vadinBB60 group","unknown genus",{"v":0.528371605127515,"d":"0.52837"},{"v":0.803021334199183,"d":"0.80302"},{"v":0.971712676197034,"d":"0.97171"},{"v":0.923939555754717,"d":"0.92394"},{"v":0.580741102305663,"d":"0.58074"},{"v":0.522504087904367,"d":"0.52250"},{"v":0.499615650897896,"d":"0.49962"},{"v":0.3242571713384,"d":"0.32426"},{"v":0.975441628826388,"d":"0.97544"},{"v":0.950906082532681,"d":"0.95091"},{"v":0.872134554769653,"d":"0.87213"},{"v":0.260525559756516,"d":"0.26053"},{"v":0.409741328983929,"d":"0.40974"},{"v":0.17940698932167,"d":"0.17941"},{"v":0.0523069559934132,"d":"0.05231"},{"v":0.0640095185611601,"d":"0.06401"},{"v":0.372689860294037,"d":"0.37269"},{"v":0.000795670460535551,"d":"0.00080"},{"v":0.181511004079731,"d":"0.18151"},{"v":0.603697281273283,"d":"0.60370"},{"v":0.644031081370501,"d":"0.64403"},{"v":0.671133816136125,"d":"0.67113"},{"v":0.671703098501795,"d":"0.67170"},{"v":0.802116766197447,"d":"0.80212"},{"v":0.958666643780939,"d":"0.95867"},{"v":0.991463869403804,"d":"0.99146"}]
[null,null,"Cluster_54","-","Lactobacillaceae","Lactobacillus",{"v":0.383735281424254,"d":"0.38374"},{"v":0.00608271715245792,"d":"0.00608"},{"v":0.0312228763387221,"d":"0.03122"},{"v":0.0305268709309723,"d":"0.03053"},{"v":0.163993502295876,"d":"0.16399"},{"v":0.139943473501455,"d":"0.13994"},{"v":0.0421646320258633,"d":"0.04216"},{"v":0.56161553067589,"d":"0.56162"},{"v":0.723660415245747,"d":"0.72366"},{"v":0.167141379538438,"d":"0.16714"},{"v":0.912804286357019,"d":"0.91280"},{"v":0.548772823509541,"d":"0.54877"},{"v":0.724245328568437,"d":"0.72425"},{"v":0.0561651237158632,"d":"0.05617"},{"v":0.039858137667726,"d":"0.03986"},{"v":0.446513982121316,"d":"0.44651"},{"v":0.0021701097308907,"d":"0.00217"},{"v":0.525306188279181,"d":"0.52531"},{"v":0.508435380669942,"d":"0.50844"},{"v":0.937569002461741,"d":"0.93757"},{"v":0.0147031834711353,"d":"0.01470"},{"v":0.507604329247153,"d":"0.50760"},{"v":0.0312548275196586,"d":"0.03125"},{"v":0.0651741307155369,"d":"0.06517"},{"v":0.881352471658812,"d":"0.88135"},{"v":0.087401121592251,"d":"0.08740"}]
[null,null,"Cluster_422","Proteobacteria","Enterobacteriaceae","Escherichia-Shigella",{"v":0.646833482215311,"d":"0.64683"},{"v":0.211321958730581,"d":"0.21132"},{"v":0.000855289989109819,"d":"0.00086"},{"v":0.0920464421162633,"d":"0.09205"},{"v":0.483836941864534,"d":"0.48384"},{"v":0.0392163889497707,"d":"0.03922"},{"v":0.154697761085239,"d":"0.15470"},{"v":0.393233233148657,"d":"0.39323"},{"v":0.190566333287911,"d":"0.19057"},{"v":0.259691063160603,"d":"0.25969"},{"v":0.173695728568776,"d":"0.17370"},{"v":0.0379204881200617,"d":"0.03792"},{"v":0.0240258464019462,"d":"0.02403"},{"v":0.0707539215141762,"d":"0.07075"},{"v":0.991165803383477,"d":"0.99117"},{"v":0.0725903151058322,"d":"0.07259"},{"v":0.0161740633901611,"d":"0.01617"},{"v":0.350375015690466,"d":"0.35038"},{"v":0.98109306802317,"d":"0.98109"},{"v":0.00076972919720693,"d":"0.00077"},{"v":0.345732455563917,"d":"0.34573"},{"v":0.678263060136613,"d":"0.67826"},{"v":1.17161749334145E-3,"d":"0.00117"},{"v":1.56927426471259E-3,"d":"0.00157"},{"v":0.391496018652034,"d":"0.39150"},{"v":0.268573071003058,"d":"0.26857"}]
[null,null,"Cluster_711","-","-","Escherichia-Shigella",{"v":0.688291541015291,"d":"0.68829"},{"v":0.394975021154556,"d":"0.39498"},{"v":3.6972566396524E-4,"d":"0.00037"},{"v":0.027554357152595,"d":"0.02755"},{"v":0.127168231744169,"d":"0.12717"},{"v":0.268799947114574,"d":"0.26880"},{"v":0.0351877804875835,"d":"0.03519"},{"v":0.398472297331926,"d":"0.39847"},{"v":0.311677470385185,"d":"0.31168"},{"v":0.310174405286556,"d":"0.31017"},{"v":0.404636375286451,"d":"0.40464"},{"v":0.219077803882244,"d":"0.21908"},{"v":0.0823536303727659,"d":"0.08235"},{"v":0.0693241942787866,"d":"0.06932"},{"v":0.469900808961367,"d":"0.46990"},{"v":1.21691012399505E-3,"d":"0.00122"},{"v":0.0889207395433614,"d":"0.08892"},{"v":0.173319771442409,"d":"0.17332"},{"v":0.778279390845501,"d":"0.77828"},{"v":0.000143414947590022,"d":"0.00014"},{"v":0.429846099915423,"d":"0.42985"},{"v":0.96146142494192,"d":"0.96146"},{"v":0.00175466665364413,"d":"0.00175"},{"v":0.00178828290133413,"d":"0.00179"},{"v":0.507855031212082,"d":"0.50786"},{"v":0.307849384219406,"d":"0.30785"}]
[null,null,"Cluster_544","-","-","Escherichia-Shigella",{"v":0.560561823837117,"d":"0.56056"},{"v":0.111483743801923,"d":"0.11148"},{"v":2.41097603671106E-3,"d":"0.00241"},{"v":0.0359717386105849,"d":"0.03597"},{"v":0.0992930607742922,"d":"0.09929"},{"v":0.341726863369476,"d":"0.34173"},{"v":0.0230700083306765,"d":"0.02307"},{"v":0.972334128329065,"d":"0.97233"},{"v":0.332428947585383,"d":"0.33243"},{"v":0.160534342085569,"d":"0.16053"},{"v":0.11274576078988,"d":"0.11275"},{"v":0.646553020031916,"d":"0.64655"},{"v":0.571938106427626,"d":"0.57194"},{"v":0.0397606072347467,"d":"0.03976"},{"v":0.580689351713144,"d":"0.58069"},{"v":0.132822848667302,"d":"0.13282"},{"v":0.0111723433359948,"d":"0.01117"},{"v":0.214663438630527,"d":"0.21466"},{"v":0.424544208055101,"d":"0.42454"},{"v":4.38642125120957e-06,"d":"0.00000"},{"v":0.221010418125814,"d":"0.22101"},{"v":0.488002112674044,"d":"0.48800"},{"v":0.000996033953699097,"d":"0.00100"},{"v":0.00727837071980393,"d":"0.00728"},{"v":0.474353489477647,"d":"0.47435"},{"v":0.149581602425056,"d":"0.14958"}]
[null,null,"Cluster_453","-","-","Escherichia-Shigella",{"v":0.344527707530405,"d":"0.34453"},{"v":0.043201289887892,"d":"0.04320"},{"v":0.0038542145659055,"d":"0.00385"},{"v":0.0864663542685294,"d":"0.08647"},{"v":0.28039757371857,"d":"0.28040"},{"v":0.32137005382773,"d":"0.32137"},{"v":0.106631404822781,"d":"0.10663"},{"v":0.694334680944591,"d":"0.69433"},{"v":0.193941921912315,"d":"0.19394"},{"v":0.190969148486745,"d":"0.19097"},{"v":0.380529106602319,"d":"0.38053"},{"v":0.0360077171965757,"d":"0.03601"},{"v":0.0706912702409857,"d":"0.07069"},{"v":0.0160649513986597,"d":"0.01606"},{"v":0.534693740627834,"d":"0.53469"},{"v":0.0526217757746483,"d":"0.05262"},{"v":0.0282808789013558,"d":"0.02828"},{"v":0.245140408509861,"d":"0.24514"},{"v":0.830162315087649,"d":"0.83016"},{"v":0.000259857889348885,"d":"0.00026"},{"v":0.365989763729769,"d":"0.36599"},{"v":0.789780891241064,"d":"0.78978"},{"v":3.39796138935903E-3,"d":"0.00340"},{"v":0.00476160102932788,"d":"0.00476"},{"v":0.572735801122523,"d":"0.57274"},{"v":0.159990206967135,"d":"0.15999"}]
[null,null,"Cluster_396","-","-","Proteus",{"v":0.152018313293538,"d":"0.15202"},{"v":0.930032616931722,"d":"0.93003"},{"v":0.196479851293564,"d":"0.19648"},{"v":0.011104744449647,"d":"0.01110"},{"v":0.186759267871672,"d":"0.18676"},{"v":0.177198351671908,"d":"0.17720"},{"v":0.160038582216383,"d":"0.16004"},{"v":0.766227648950324,"d":"0.76623"},{"v":0.770536300891586,"d":"0.77054"},{"v":0.826526844634469,"d":"0.82653"},{"v":0.929260610526129,"d":"0.92926"},{"v":0.114160325719615,"d":"0.11416"},{"v":0.0365183135228122,"d":"0.03652"},{"v":0.00315372724953132,"d":"0.00315"},{"v":0.0179685047456131,"d":"0.01797"},{"v":0.490319782085853,"d":"0.49032"},{"v":0.00383908101359834,"d":"0.00384"},{"v":0.979078823394056,"d":"0.97908"},{"v":0.298943135538234,"d":"0.29894"},{"v":0.145455461827224,"d":"0.14546"},{"v":0.0204418247823186,"d":"0.02044"},{"v":0.694298366042656,"d":"0.69430"},{"v":0.000230271486298143,"d":"0.00023"},{"v":0.0491246585691535,"d":"0.04912"},{"v":0.182617233782516,"d":"0.18262"},{"v":0.149581602425056,"d":"0.14958"}]
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[null,null,"Cluster_3","-","unknown family","unknown genus",{"v":0.469288824407856,"d":"0.46929"},{"v":0.334196873586588,"d":"0.33420"},{"v":0.00122060103832567,"d":"0.00122"},{"v":0.0117959687766462,"d":"0.01180"},{"v":0.501357559294943,"d":"0.50136"},{"v":0.00735149171883562,"d":"0.00735"},{"v":0.120646464489642,"d":"0.12065"},{"v":0.706188004035594,"d":"0.70619"},{"v":0.0918148362777864,"d":"0.09181"},{"v":0.0407480514084113,"d":"0.04075"},{"v":0.121891380871358,"d":"0.12189"},{"v":0.54020458118733,"d":"0.54020"},{"v":0.00741600141065831,"d":"0.00742"},{"v":0.000821112076147706,"d":"0.00082"},{"v":0.576289112968575,"d":"0.57629"},{"v":0.183812118336696,"d":"0.18381"},{"v":0.00977254923901584,"d":"0.00977"},{"v":0.821165561551103,"d":"0.82117"},{"v":0.335670932936675,"d":"0.33567"},{"v":3.48605436082128e-07,"d":"0.00000"},{"v":0.0413906457292402,"d":"0.04139"},{"v":0.745405032557063,"d":"0.74541"},{"v":5.41386149570384e-05,"d":"0.00005"},{"v":8.7161327501578e-05,"d":"0.00009"},{"v":0.536074053674113,"d":"0.53607"},{"v":0.213428758845312,"d":"0.21343"}]
[null,"Summary of the significant correlation observed with spearman coefficient between OTU relative abundance and the immune parameters in the subgroup of hen that displayed an extreme response for IBV vaccination (HR and LR)."]
[null,"High (>0.5) and intermediate (0.4) correlation that are significant (adj-pvalue<0.05) are highlighted in bold letter. OTU taxonomy is given at the phylum, family, and genus level when available, with '-' indicating that the annotation is the same than the taxonomy of the above OTU."]

{"sheet":"Table S10","index":13,"n_rows":1722,"n_cols":6,"rows_kept":1722}
[]
[null,"Table S10: Differential analysis on the KEGG genes predicted counts between the low and high responders to IBV vaccination."]
[null,"Vaccine response group for which the predicted KEGG genes display higher abundance","KEGG identifiant","Log2FC","p-values","adjusted p-values"]
[null,"High Responder","K00058",{"v":-0.313223058859877,"d":"-0.313"},{"v":0.0117881065267395,"d":"0.012"},{"v":0.0333454029667933,"d":"0.033"}]
[null,null,"K00067",{"v":-0.303235721623385,"d":"-0.303"},{"v":0.0161257886959455,"d":"0.016"},{"v":0.0431264420106871,"d":"0.043"}]
[null,null,"K00074",{"v":-0.288025020691783,"d":"-0.288"},{"v":0.0154261788728865,"d":"0.015"},{"v":0.0418008657078396,"d":"0.042"}]
[null,null,"K00086",{"v":-2.12652794598789,"d":"-2.127"},{"v":0.00101880694775693,"d":"0.001"},{"v":0.0033048924657813,"d":"0.003"}]
[null,null,"K00097",{"v":-0.38339221243809,"d":"-0.383"},{"v":0.0109927927375085,"d":"0.011"},{"v":0.0313712040844468,"d":"0.031"}]
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[null,null,"K19778",{"v":1.57616710391575,"d":"1.5762"},{"v":1.18385094291855E-4,"d":"0.0001"},{"v":0.00043321772898603,"d":"0.0004"}]
[null,null,"K19784",{"v":1.53014507783516,"d":"1.5301"},{"v":9.14901331344919e-05,"d":"0.0001"},{"v":0.00043321772898603,"d":"0.0004"}]
[null,null,"K19789",{"v":1.5767328662312,"d":"1.5767"},{"v":0.000116073955233614,"d":"0.0001"},{"v":0.00043321772898603,"d":"0.0004"}]

{"sheet":"Table S11","index":14,"n_rows":12,"n_cols":7,"rows_kept":12,"merged":[[2,1,3,1],[2,2,2,3],[2,4,3,4],[2,5,3,5],[2,6,3,6]]}
[]
[null,"Table S11: pathway enrichment on the KEGG genes differentialy abundant between low and high responders to IBV vaccination."]
[null,"Group with pathway enrichment","Pathway",null,"p-values","adjusted p-values","Bgratio"]
[null,null,"ID","Identification"]
[null,"Low Responder","ko01503","Cationic antimicrobial peptide (CAMP) resistance",{"v":1.08286998499537e-11,"d":"1.08E-11"},{"v":1.22364308304477e-09,"d":"1.22E-09"},"38/2351"]
[null,null,"ko02020","Two-component system",{"v":1.57979081862853e-09,"d":"1.58E-09"},{"v":7.51209798003082e-08,"d":"7.51E-08"},"236/2351"]
[null,null,"ko02026","Biofilm formation - Escherichia coli formation",{"v":1.9943622955834e-09,"d":"1.99E-09"},{"v":7.51209798003082e-08,"d":"7.51E-08"},"43/2351"]
[null,null,"ko00540","Lipopolysaccharide biosynthesis",{"v":4.73592760085945E-9,"d":"4.74E-09"},{"v":1.33789954724279E-7,"d":"1.34E-07"},"44/2351"]
[null,null,"ko03070","Bacterial secretion system",{"v":7.36067184654972e-05,"d":"7.36E-05"},{"v":0.00166351183732024,"d":"1.66E-03"},"58/2351"]
[null,null,"ko05111","Biofilm formation - Vibrio cholerae",{"v":0.000274924467558002,"d":"2.75E-04"},{"v":0.00517774413900904,"d":"5.18E-03"},"32/2351"]
[null,null,"ko00360","Phenylalanine metabolism",{"v":0.00146372098536735,"d":"1.46E-03"},{"v":0.0236286387637872,"d":"2.36E-02"},"41/2351"]
[null,"High Responder","ko02024","Quorum sensing",{"v":1.59983434763976e-05,"d":"1.60E-05"},{"v":0.0013758575389702,"d":"1.38E-03"},"80/2351"]

{"sheet":"Table12","index":15,"n_rows":22,"n_cols":35,"rows_kept":22}
[]
[null,"Table S12: Spearman corelation coeficient between OTU relative abundance and immune parameters calculated on the whole population."]
[null,"Indice","OTU","Phylum","Class","Order","Family","Genus","Species","Thrombocytes","Heterophils","Monocytes","B cells","TCRϒδ+ T  cells","Frequency of TCR1+CD8+ ϒδ T cells","Frequency of TCR1+CD8- ϒδ T cells","Frequency of (ab) T cells","Frequency of TCR1-CD8+ (ab) T cells","Frequency of TCR1-CD4+ (ab) T cells","Frequency of TCR1-CD4+CD25+ (ab) T cells","Frequency of Thrombocytes","CD45 expression on Thrombocytes","CD45 expression on heterophils","MRC1L-B expression on Monocytes","CD45 expression on monocytes","MHCII expression on monocytes","Bu1 expression on B cells","IgM on B cells","TCRϒδ expression on TCRϒδ+ T cells","CD8 β expression on CD8 αβ+ TCR ϒδ+  T cells","CD8 β expression on CD8 αβ+ T cells","CD4 expression on CD4+ T cells","CD4 expression on CD4+ CD25+ T cells","CD25 expression on CD4+ CD25+ T cells","MHC II expression on B cells"]
[null,"Spearman correlation","Cluster_52","Firmicutes","Clostridia","Clostridiales","Ruminococcaceae","Ruminococcaceae UCG-014","unknown species",{"v":-0.233565098027513,"d":"-0.23"},{"v":-0.270746918922145,"d":"-0.27"},{"v":-0.0548775029094924,"d":"-0.05"},{"v":-0.0589955536987855,"d":"-0.06"},{"v":0.139312464563875,"d":"0.14"},{"v":0.101727790874638,"d":"0.10"},{"v":0.132717615111456,"d":"0.13"},{"v":-0.152502163468712,"d":"-0.15"},{"v":-0.0996389245322431,"d":"-0.10"},{"v":-0.191161111276894,"d":"-0.19"},{"v":-0.142908298767569,"d":"-0.14"},{"v":0.0781086807317,"d":"0.08"},{"v":-0.0200232759392438,"d":"-0.02"},{"v":0.0275730357196144,"d":"0.03"},{"v":0.0527739129465376,"d":"0.05"},{"v":-0.0157336983890653,"d":"-0.02"},{"v":0.400017904568649,"d":"0.40"},{"v":-0.0235146668258184,"d":"-0.02"},{"v":-0.0825851309468718,"d":"-0.08"},{"v":0.230103548088687,"d":"0.23"},{"v":0.156083077198532,"d":"0.16"},{"v":0.230103548088687,"d":"0.23"},{"v":-0.0489839157291635,"d":"-0.05"},{"v":0.093790098773537,"d":"0.09"},{"v":0.0757960072811912,"d":"0.08"},{"v":0.115991763898421,"d":"0.12"}]
[null,"coefficient","Cluster_370","-","-","-","-","Eubacterium coprostanoligenes group","unknown species",{"v":0.140237533944078,"d":"0.14"},{"v":0.00583390528483185,"d":"0.01"},{"v":0.0974008534511056,"d":"0.10"},{"v":0.0656053236250783,"d":"0.07"},{"v":0.175643818447674,"d":"0.18"},{"v":0.212586911760317,"d":"0.21"},{"v":0.121542180179642,"d":"0.12"},{"v":0.192250305869714,"d":"0.19"},{"v":0.156187520515652,"d":"0.16"},{"v":0.107845185163081,"d":"0.11"},{"v":0.0906567992599445,"d":"0.09"},{"v":0.0648145385097431,"d":"0.06"},{"v":0.063322491122318,"d":"0.06"},{"v":-0.0581749276357017,"d":"-0.06"},{"v":-0.0461193567762928,"d":"-0.05"},{"v":-0.115760928356153,"d":"-0.12"},{"v":0.0780340783623288,"d":"0.08"},{"v":0.122318044821103,"d":"0.12"},{"v":-0.146459917863504,"d":"-0.15"},{"v":0.147533645668586,"d":"0.15"},{"v":0.12925606517263,"d":"0.13"},{"v":0.180373608665811,"d":"0.18"},{"v":0.419787532452031,"d":"0.42"},{"v":0.0279460475664707,"d":"0.03"},{"v":-0.0151592014562382,"d":"-0.02"},{"v":0.0868520784220107,"d":"0.09"}]
[null,null,"Cluster_561","-","-","-","-","Negativibacillus","unknown species",{"v":0.137059473008863,"d":"0.14"},{"v":0.0544448091671391,"d":"0.05"},{"v":0.00486407448300558,"d":"0.00"},{"v":0.0381665721703321,"d":"0.04"},{"v":0.0877920682760884,"d":"0.09"},{"v":0.120169496583211,"d":"0.12"},{"v":0.0610396586195577,"d":"0.06"},{"v":0.143549879144162,"d":"0.14"},{"v":0.181761212736116,"d":"0.18"},{"v":0.218271612306407,"d":"0.22"},{"v":0.0553101966518457,"d":"0.06"},{"v":0.0593984064933902,"d":"0.06"},{"v":0.00995195607412491,"d":"0.01"},{"v":-0.0164423622094238,"d":"-0.02"},{"v":-0.0273045690393452,"d":"-0.03"},{"v":-0.0416058965935595,"d":"-0.04"},{"v":-0.00522216585598759,"d":"-0.01"},{"v":0.1408045119513,"d":"0.14"},{"v":-0.00650535087494781,"d":"-0.01"},{"v":0.0197248664617588,"d":"0.02"},{"v":0.181791053683865,"d":"0.18"},{"v":0.0248873504222494,"d":"0.02"},{"v":0.423428128077348,"d":"0.42"},{"v":-0.0264092387574229,"d":"-0.03"},{"v":-0.135477902778192,"d":"-0.14"},{"v":0.075303631643341,"d":"0.08"}]
[null,null,"Cluster_335","-","-","-","unknown family","unknown genus","unknown species",{"v":0.214347527677479,"d":"0.21"},{"v":-0.0490734385724091,"d":"-0.05"},{"v":0.0853749515084599,"d":"0.09"},{"v":0.160335412252693,"d":"0.16"},{"v":0.309480469099699,"d":"0.31"},{"v":0.259138790247978,"d":"0.26"},{"v":0.276237653307869,"d":"0.28"},{"v":0.329309778878577,"d":"0.33"},{"v":0.253185521172152,"d":"0.25"},{"v":0.205932380412402,"d":"0.21"},{"v":0.210483124944048,"d":"0.21"},{"v":-0.0248276685267524,"d":"-0.02"},{"v":-0.00571454149383784,"d":"-0.01"},{"v":-0.0881203187013219,"d":"-0.09"},{"v":-0.0426354131311086,"d":"-0.04"},{"v":-0.0121378507724084,"d":"-0.01"},{"v":0.0307361761809555,"d":"0.03"},{"v":0.0357196144549551,"d":"0.04"},{"v":-0.0859944719444075,"d":"-0.09"},{"v":0.14736952045597,"d":"0.15"},{"v":0.0911790158455432,"d":"0.09"},{"v":0.077571543672227,"d":"0.08"},{"v":0.401122019635344,"d":"0.40"},{"v":0.0962668974366626,"d":"0.10"},{"v":-0.0883292053355614,"d":"-0.09"},{"v":-0.0143833368147772,"d":"-0.01"}]
[null,null,"Cluster_544","Proteobacteria","Gammaproteobacteria","Enterobacteriales","Enterobacteriaceae","Escherichia-Shigella","unknown species",{"v":-0.0490883590462833,"d":"-0.05"},{"v":0.0731103219838262,"d":"0.07"},{"v":-0.0847632120796156,"d":"-0.08"},{"v":-0.0979529109844528,"d":"-0.10"},{"v":-0.248231923845901,"d":"-0.25"},{"v":-0.251409984781117,"d":"-0.25"},{"v":-0.22874578496613,"d":"-0.23"},{"v":-0.0128912894273522,"d":"-0.01"},{"v":0.0957446808510638,"d":"0.10"},{"v":0.193966160365253,"d":"0.19"},{"v":0.105517591238698,"d":"0.11"},{"v":0.00211870729014353,"d":"0.00"},{"v":-0.0616066366267793,"d":"-0.06"},{"v":-0.0415236787920384,"d":"-0.04"},{"v":-0.0138537116683235,"d":"-0.01"},{"v":-0.217780049015455,"d":"-0.22"},{"v":-0.143654322461281,"d":"-0.14"},{"v":0.24696368356659,"d":"0.25"},{"v":0.270882213611645,"d":"0.27"},{"v":-0.515905225149951,"d":"-0.52"},{"v":-0.275640834352899,"d":"-0.28"},{"v":-0.243009757989914,"d":"-0.24"},{"v":-0.19532392348781,"d":"-0.20"},{"v":-0.243651338366506,"d":"-0.24"},{"v":0.0670227686431321,"d":"0.07"},{"v":-0.00886276148130464,"d":"-0.01"}]
[null,null,"Cluster_453","-","-","-","-","-","unknown species",{"v":-0.048894392885918,"d":"-0.05"},{"v":0.0647846975619946,"d":"0.06"},{"v":-0.0743934827370117,"d":"-0.07"},{"v":-0.0227984840798544,"d":"-0.02"},{"v":-0.186386559637134,"d":"-0.19"},{"v":-0.146101280176658,"d":"-0.15"},{"v":-0.185461490256931,"d":"-0.19"},{"v":0.00690817940377786,"d":"0.01"},{"v":0.0981021157231954,"d":"0.10"},{"v":0.11373877234341,"d":"0.11"},{"v":0.0558174927635702,"d":"0.06"},{"v":0.155247530661574,"d":"0.16"},{"v":0.0416728835307809,"d":"0.04"},{"v":0.0610396586195577,"d":"0.06"},{"v":0.00364806947001087,"d":"0.00"},{"v":-0.208201069057389,"d":"-0.21"},{"v":-0.0780788397839515,"d":"-0.08"},{"v":0.205619050461043,"d":"0.21"},{"v":0.172145609448877,"d":"0.17"},{"v":-0.410044463012145,"d":"-0.41"},{"v":-0.217794157142431,"d":"-0.22"},{"v":-0.169988958849333,"d":"-0.17"},{"v":-0.209199964190863,"d":"-0.21"},{"v":-0.387827877413387,"d":"-0.39"},{"v":0.175390170391812,"d":"0.18"},{"v":0.0869863626868789,"d":"0.09"}]
[null,null,"Cluster_422","-","-","-","-","-","unknown species",{"v":-0.0299155501178717,"d":"-0.03"},{"v":0.0958192832204351,"d":"0.10"},{"v":-0.0527886365670974,"d":"-0.05"},{"v":-0.0455671272119602,"d":"-0.05"},{"v":-0.174420339589985,"d":"-0.17"},{"v":-0.136880427322372,"d":"-0.14"},{"v":-0.185804661156038,"d":"-0.19"},{"v":-0.029572379218764,"d":"-0.03"},{"v":0.0689773507206589,"d":"0.07"},{"v":0.103637611530542,"d":"0.10"},{"v":0.0695890901495031,"d":"0.07"},{"v":0.132389364686222,"d":"0.13"},{"v":-0.0200381964131181,"d":"-0.02"},{"v":-0.0713646265405389,"d":"-0.07"},{"v":-0.0212990559036422,"d":"-0.02"},{"v":-0.279789769740874,"d":"-0.28"},{"v":-0.17243591656471,"d":"-0.17"},{"v":0.175807943660291,"d":"0.18"},{"v":0.144333742405522,"d":"0.14"},{"v":-0.43263406045776,"d":"-0.43"},{"v":-0.189579541046224,"d":"-0.19"},{"v":-0.137581689594461,"d":"-0.14"},{"v":-0.141416251380144,"d":"-0.14"},{"v":-0.340082361015786,"d":"-0.34"},{"v":0.0491480409417803,"d":"0.05"},{"v":-0.00558025722896959,"d":"-0.01"}]
[null,null,"Cluster_711","-","-","-","-","-","Streptomyces sp.",{"v":-0.14407209572976,"d":"-0.14"},{"v":0.0369430933126436,"d":"0.04"},{"v":-0.0969084778132553,"d":"-0.10"},{"v":-0.144146698099132,"d":"-0.14"},{"v":-0.348915281549342,"d":"-0.35"},{"v":-0.28199695622333,"d":"-0.28"},{"v":-0.347274029423174,"d":"-0.35"},{"v":-0.190967145116529,"d":"-0.19"},{"v":-0.0799737399659813,"d":"-0.08"},{"v":-0.0149950762436215,"d":"-0.01"},{"v":-0.0835546536958014,"d":"-0.08"},{"v":0.0130703351138432,"d":"0.01"},{"v":-0.0394944943451404,"d":"-0.04"},{"v":-0.0843603592850109,"d":"-0.08"},{"v":-0.149720053565743,"d":"-0.15"},{"v":-0.254842644367221,"d":"-0.25"},{"v":-0.0879412730148309,"d":"-0.09"},{"v":0.179060606964877,"d":"0.18"},{"v":0.176263675599073,"d":"0.18"},{"v":-0.455447465011489,"d":"-0.46"},{"v":-0.216988451553221,"d":"-0.22"},{"v":-0.165095043418579,"d":"-0.17"},{"v":-0.0706633642684492,"d":"-0.07"},{"v":-0.20855838381427,"d":"-0.21"},{"v":0.10257825788547,"d":"0.10"},{"v":-0.00990719465250216,"d":"-0.01"}]
[null,null,"Cluster_3","-","-","unknown order","unknown family","unknown genus","unknown species",{"v":0.00631136044880785,"d":"0.01"},{"v":0.0974903762943511,"d":"0.10"},{"v":-0.0316314046134105,"d":"-0.03"},{"v":-0.0632926501745695,"d":"-0.06"},{"v":-0.20259019426457,"d":"-0.20"},{"v":-0.126525618453642,"d":"-0.13"},{"v":-0.206544119841246,"d":"-0.21"},{"v":0.0128614484796037,"d":"0.01"},{"v":0.0460744233236848,"d":"0.05"},{"v":0.159499865715735,"d":"0.16"},{"v":0.093849780669034,"d":"0.09"},{"v":0.0484616991435648,"d":"0.05"},{"v":-0.0236638715645609,"d":"-0.02"},{"v":-0.0447912625704992,"d":"-0.04"},{"v":-0.0812721243482585,"d":"-0.08"},{"v":-0.239646085041225,"d":"-0.24"},{"v":-0.134075378234013,"d":"-0.13"},{"v":0.131807466205127,"d":"0.13"},{"v":0.15353224886058,"d":"0.15"},{"v":-0.4592074244278,"d":"-0.46"},{"v":-0.220285876279431,"d":"-0.22"},{"v":-0.210184715466563,"d":"-0.21"},{"v":-0.138521679448539,"d":"-0.14"},{"v":-0.35512219868103,"d":"-0.36"},{"v":0.0921040852257467,"d":"0.09"},{"v":0.00475963116588583,"d":"0.00"}]
[null,"associated adjusted p-value","Cluster_52","Firmicutes","Clostridia","Clostridiales","Ruminococcaceae","Ruminococcaceae UCG-014","unknown species",{"v":0.138847112563924,"d":"0.139"},{"v":0.115006194267495,"d":"0.115"},{"v":0.756901510850581,"d":"0.757"},{"v":0.756901510850581,"d":"0.757"},{"v":0.474770674560535,"d":"0.475"},{"v":0.633949466301888,"d":"0.634"},{"v":0.483015042411353,"d":"0.483"},{"v":0.468898853785828,"d":"0.469"},{"v":0.633949466301888,"d":"0.634"},{"v":0.288253298721719,"d":"0.288"},{"v":0.474770674560535,"d":"0.475"},{"v":0.678238490588742,"d":"0.678"},{"v":0.881011226687622,"d":"0.881"},{"v":0.881011226687622,"d":"0.881"},{"v":0.756901510850581,"d":"0.757"},{"v":0.881011226687622,"d":"0.881"},{"v":0.0021182207618855,"d":"0.002"},{"v":0.881011226687622,"d":"0.881"},{"v":0.678238490588742,"d":"0.678"},{"v":0.138847112563924,"d":"0.139"},{"v":0.468898853785828,"d":"0.469"},{"v":0.138847112563924,"d":"0.139"},{"v":0.756901510850581,"d":"0.757"},{"v":0.642292121575127,"d":"0.642"},{"v":0.678238490588742,"d":"0.678"},{"v":0.579992659486404,"d":"0.580"}]
[null,null,"Cluster_370","-","-","-","-","Eubacterium coprostanoligenes group","unknown species",{"v":0.519117039341922,"d":"0.519"},{"v":0.955709064136762,"d":"0.956"},{"v":0.610745093672101,"d":"0.611"},{"v":0.675818458952048,"d":"0.676"},{"v":0.479258283054562,"d":"0.479"},{"v":0.479258283054562,"d":"0.479"},{"v":0.531576925340456,"d":"0.532"},{"v":0.479258283054562,"d":"0.479"},{"v":0.519117039341922,"d":"0.519"},{"v":0.562567062160837,"d":"0.563"},{"v":0.622633330872836,"d":"0.623"},{"v":0.675818458952048,"d":"0.676"},{"v":0.675818458952048,"d":"0.676"},{"v":0.684297475621084,"d":"0.684"},{"v":0.746853261735753,"d":"0.747"},{"v":0.538337224491959,"d":"0.538"},{"v":0.659393517684376,"d":"0.659"},{"v":0.531576925340456,"d":"0.532"},{"v":0.519117039341922,"d":"0.519"},{"v":0.519117039341922,"d":"0.519"},{"v":0.531576925340456,"d":"0.532"},{"v":0.479258283054562,"d":"0.479"},{"v":0.000864738679849115,"d":"0.001"},{"v":0.855796843000276,"d":"0.856"},{"v":0.920563139773706,"d":"0.921"},{"v":0.622633330872836,"d":"0.623"}]
[null,null,"Cluster_561","-","-","-","-","Negativibacillus","unknown species",{"v":0.633859030955128,"d":"0.634"},{"v":0.963075715864945,"d":"0.963"},{"v":0.963075715864945,"d":"0.963"},{"v":0.963075715864945,"d":"0.963"},{"v":0.963075715864945,"d":"0.963"},{"v":0.724375524612388,"d":"0.724"},{"v":0.963075715864945,"d":"0.963"},{"v":0.633859030955128,"d":"0.634"},{"v":0.528120972690766,"d":"0.528"},{"v":0.464809487489548,"d":"0.465"},{"v":0.963075715864945,"d":"0.963"},{"v":0.963075715864945,"d":"0.963"},{"v":0.963075715864945,"d":"0.963"},{"v":0.963075715864945,"d":"0.963"},{"v":0.963075715864945,"d":"0.963"},{"v":0.963075715864945,"d":"0.963"},{"v":0.963075715864945,"d":"0.963"},{"v":0.633859030955128,"d":"0.634"},{"v":0.963075715864945,"d":"0.963"},{"v":0.963075715864945,"d":"0.963"},{"v":0.528120972690766,"d":"0.528"},{"v":0.963075715864945,"d":"0.963"},{"v":0.000728988836885022,"d":"0.001"},{"v":0.963075715864945,"d":"0.963"},{"v":0.633859030955128,"d":"0.634"},{"v":0.963075715864945,"d":"0.963"}]
[null,null,"Cluster_335","-","-","-","unknown family","unknown genus","unknown species",{"v":0.138146749615074,"d":"0.138"},{"v":0.875575867823471,"d":"0.876"},{"v":0.634941736318336,"d":"0.635"},{"v":0.323944584373419,"d":"0.324"},{"v":0.0229187685556036,"d":"0.023"},{"v":0.0630180121428906,"d":"0.063"},{"v":0.0489159213334883,"d":"0.049"},{"v":0.0174108196602976,"d":"0.017"},{"v":0.0630180121428906,"d":"0.063"},{"v":0.138146749615074,"d":"0.138"},{"v":0.138146749615074,"d":"0.138"},{"v":0.918990735426482,"d":"0.919"},{"v":0.956615539958785,"d":"0.957"},{"v":0.634941736318336,"d":"0.635"},{"v":0.890370947907553,"d":"0.890"},{"v":0.944391941942818,"d":"0.944"},{"v":0.90946846659917,"d":"0.909"},{"v":0.908121972731196,"d":"0.908"},{"v":0.634941736318336,"d":"0.635"},{"v":0.374388633912936,"d":"0.374"},{"v":0.634941736318336,"d":"0.635"},{"v":0.663264146682719,"d":"0.663"},{"v":0.00201761517270303,"d":"0.002"},{"v":0.634941736318336,"d":"0.635"},{"v":0.634941736318336,"d":"0.635"},{"v":0.944391941942818,"d":"0.944"}]
[null,null,"Cluster_544","Proteobacteria","Gammaproteobacteria","Enterobacteriales","Enterobacteriaceae","Escherichia-Shigella","unknown species",{"v":0.792061593969169,"d":"0.792"},{"v":0.701235234391862,"d":"0.701"},{"v":0.640080445819782,"d":"0.640"},{"v":0.586024570690024,"d":"0.586"},{"v":0.0621720470741362,"d":"0.062"},{"v":0.0621720470741362,"d":"0.062"},{"v":0.0798183285847373,"d":"0.080"},{"v":0.970038480184694,"d":"0.970"},{"v":0.586024570690024,"d":"0.586"},{"v":0.135572230622691,"d":"0.136"},{"v":0.58225528530896,"d":"0.582"},{"v":0.983943837334479,"d":"0.984"},{"v":0.723846790551832,"d":"0.724"},{"v":0.818057511160744,"d":"0.818"},{"v":0.970038480184694,"d":"0.970"},{"v":0.0935762675592095,"d":"0.094"},{"v":0.338483867027971,"d":"0.338"},{"v":0.0621720470741362,"d":"0.062"},{"v":0.0621720470741362,"d":"0.062"},{"v":4.8834167763999e-06,"d":"0.000005"},{"v":0.0621720470741362,"d":"0.062"},{"v":0.0621720470741362,"d":"0.062"},{"v":0.135572230622691,"d":"0.136"},{"v":0.0621720470741362,"d":"0.062"},{"v":0.715137583976637,"d":"0.715"},{"v":0.970038480184694,"d":"0.970"}]
[null,null,"Cluster_453","-","-","-","-","-","unknown species",{"v":0.757624147893083,"d":"0.758"},{"v":0.728581356942758,"d":"0.729"},{"v":0.690196224026976,"d":"0.690"},{"v":0.896998569873822,"d":"0.897"},{"v":0.244070644073637,"d":"0.244"},{"v":0.324075741210456,"d":"0.324"},{"v":0.244070644073637,"d":"0.244"},{"v":0.972314967472156,"d":"0.972"},{"v":0.604732445873667,"d":"0.605"},{"v":0.514691782726263,"d":"0.515"},{"v":0.736067943387474,"d":"0.736"},{"v":0.297107996356222,"d":"0.297"},{"v":0.781302844191984,"d":"0.781"},{"v":0.728581356942758,"d":"0.729"},{"v":0.972314967472156,"d":"0.972"},{"v":0.208718247149661,"d":"0.209"},{"v":0.690196224026976,"d":"0.690"},{"v":0.208718247149661,"d":"0.209"},{"v":0.244070644073637,"d":"0.244"},{"v":0.00135359599841349,"d":"0.001"},{"v":0.208718247149661,"d":"0.209"},{"v":0.244070644073637,"d":"0.244"},{"v":0.208718247149661,"d":"0.209"},{"v":0.00179340617647759,"d":"0.002"},{"v":0.244070644073637,"d":"0.244"},{"v":0.660366484827189,"d":"0.660"}]
[null,null,"Cluster_422","-","-","-","-","-","unknown species",{"v":0.879532243682383,"d":"0.880"},{"v":0.624442121358889,"d":"0.624"},{"v":0.822046013462955,"d":"0.822"},{"v":0.822046013462955,"d":"0.822"},{"v":0.319595623868032,"d":"0.320"},{"v":0.410963289482658,"d":"0.411"},{"v":0.319595623868032,"d":"0.320"},{"v":0.879532243682383,"d":"0.880"},{"v":0.737423452994014,"d":"0.737"},{"v":0.59848027790653,"d":"0.598"},{"v":0.737423452994014,"d":"0.737"},{"v":0.410963289482658,"d":"0.411"},{"v":0.882506780164426,"d":"0.883"},{"v":0.737423452994014,"d":"0.737"},{"v":0.882506780164426,"d":"0.883"},{"v":0.0572352775774004,"d":"0.057"},{"v":0.319595623868032,"d":"0.320"},{"v":0.319595623868032,"d":"0.320"},{"v":0.410963289482658,"d":"0.411"},{"v":0.00046946651937927,"d":"0.0005"},{"v":0.319595623868032,"d":"0.320"},{"v":0.410963289482658,"d":"0.411"},{"v":0.410963289482658,"d":"0.411"},{"v":0.0118111993315871,"d":"0.012"},{"v":0.822046013462955,"d":"0.822"},{"v":0.957635391438712,"d":"0.958"}]
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[null,null,"Cluster_3","-","-","unknown order","unknown family","unknown genus","unknown species",{"v":0.963869244349074,"d":"0.964"},{"v":0.616273902368561,"d":"0.616"},{"v":0.901765306033369,"d":"0.902"},{"v":0.788728680409901,"d":"0.789"},{"v":0.191715852559463,"d":"0.192"},{"v":0.452821577277307,"d":"0.453"},{"v":0.191715852559463,"d":"0.192"},{"v":0.963869244349074,"d":"0.964"},{"v":0.828712250687535,"d":"0.829"},{"v":0.409493729375707,"d":"0.409"},{"v":0.616273902368561,"d":"0.616"},{"v":0.828712250687535,"d":"0.829"},{"v":0.928736191088665,"d":"0.929"},{"v":0.828712250687535,"d":"0.829"},{"v":0.670906051544389,"d":"0.671"},{"v":0.179296427169289,"d":"0.179"},{"v":0.44957091517523,"d":"0.450"},{"v":0.44957091517523,"d":"0.450"},{"v":0.409493729375707,"d":"0.409"},{"v":1.23094173692117E-4,"d":"0.0001"},{"v":0.191715852559463,"d":"0.192"},{"v":0.191715852559463,"d":"0.192"},{"v":0.44957091517523,"d":"0.450"},{"v":0.00671866007992824,"d":"0.007"},{"v":0.616273902368561,"d":"0.616"},{"v":0.963869244349074,"d":"0.964"}]
[null,"OTU taxonomy is given at the phylum, class, order, family, and genus level when available, with '-' indicating that the annotation is the same than the taxonomy of the above OTU."]

{"sheet":"Table S13","index":16,"n_rows":42,"n_cols":35,"rows_kept":42}
[]
[null,"Table S13 : Spearman correlation between OTU abundance et immune parameters in the control group coefficient."]
[null,"Indice","OTU","Phylum","Class","Order","Family","Genus","Species","Thrombocytes","Heterophils","Monocytes","B cells","TCRϒδ+ T  cells","Frequency of TCR1+CD8+ ϒδ T cells","Frequency of TCR1+CD8- ϒδ T cells","Frequency of ab T cells","Frequency of TCR1-CD8+ (ab) T cells","Frequency of TCR1ꟷCD4+_(ab)_T cells","Frequency of TCR1̶CD4+CD25+ (ab) T cells","Frequency of Thrombocytes","CD45 expression on Thrombocytes","CD45 expression on heterophils","MRC1L-B expression on Monocytes","CD45 expression on monocytes","MHCII expression on monocytes","Bu1 expression on B cells","IgM on B cells","TCRϒδ expression on TCRϒδ+ T cells","CD8 β expression on CD8 αβ+ TCR ϒδ+  T cells","CD8 β expression on CD8 αβ+ T cells","CD4 expression on CD4+ T cells","CD4 expression on CD4+ CD25+ T cells","CD25 expression on CD4+ CD25+ T cells","MHC II expression on B cells"]
[null,"Spearman correlation","Cluster_523","Firmicutes","Clostridia","Clostridiales","Lachnospiraceae","Lachnospira","unknown species",{"v":-0.137154150197628,"d":"-0.14"},{"v":-0.322924901185771,"d":"-0.32"},{"v":-0.206851119894598,"d":"-0.21"},{"v":-0.149275362318841,"d":"-0.15"},{"v":-0.275230566534914,"d":"-0.28"},{"v":-0.0666666666666667,"d":"-0.07"},{"v":-0.313833992094862,"d":"-0.31"},{"v":-0.308168642951252,"d":"-0.31"},{"v":-0.0795783926218709,"d":"-0.08"},{"v":-0.5133069828722,"d":"-0.51"},{"v":-0.394071146245059,"d":"-0.39"},{"v":0.0635046113306983,"d":"0.06"},{"v":0.0511198945981555,"d":"0.05"},{"v":0.121870882740448,"d":"0.12"},{"v":-0.0688428472984556,"d":"-0.07"},{"v":-0.00592885375494071,"d":"-0.01"},{"v":0.558498023715415,"d":"0.56"},{"v":-0.480911756247584,"d":"-0.48"},{"v":0.00909120854276255,"d":"0.01"},{"v":0.16403162055336,"d":"0.16"},{"v":0.209881422924901,"d":"0.21"},{"v":0.360079051383399,"d":"0.36"},{"v":0.348628084118112,"d":"0.35"},{"v":0.106982872200263,"d":"0.11"},{"v":-0.0621870882740448,"d":"-0.06"},{"v":0.34361001317523,"d":"0.34"}]
[null,"coefficient","Cluster_185","-","-","-","-","Lachnospiraceae UCG-010","unknown species",{"v":0.210013175230567,"d":"0.21"},{"v":0.109090909090909,"d":"0.11"},{"v":0.0274044795783926,"d":"0.03"},{"v":0.12463768115942,"d":"0.12"},{"v":0.222397891963109,"d":"0.22"},{"v":0.131884057971014,"d":"0.13"},{"v":0.249934123847167,"d":"0.25"},{"v":0.324505928853755,"d":"0.32"},{"v":0.168247694334651,"d":"0.17"},{"v":0.427404479578393,"d":"0.43"},{"v":0.581686429512516,"d":"0.58"},{"v":0.13399209486166,"d":"0.13"},{"v":-0.0764163372859025,"d":"-0.08"},{"v":-0.373122529644269,"d":"-0.37"},{"v":-0.046510095878191,"d":"-0.05"},{"v":-0.166139657444005,"d":"-0.17"},{"v":-0.6,"d":"-0.60"},{"v":0.370960835538376,"d":"0.37"},{"v":0.0775387859045763,"d":"0.08"},{"v":-0.0748353096179183,"d":"-0.07"},{"v":-0.264558629776021,"d":"-0.26"},{"v":-0.0935441370223979,"d":"-0.09"},{"v":-0.0270759906599667,"d":"-0.03"},{"v":-0.198418972332016,"d":"-0.20"},{"v":-0.153754940711462,"d":"-0.15"},{"v":-0.274440052700922,"d":"-0.27"}]
[null,null,"Cluster_360","-","-","-","-","Sellimonas","unknown species",{"v":-0.146245059288538,"d":"-0.15"},{"v":-0.205533596837945,"d":"-0.21"},{"v":-0.144532279314888,"d":"-0.14"},{"v":-0.116469038208169,"d":"-0.12"},{"v":-0.000527009222661397,"d":"-0.00"},{"v":-0.138076416337286,"d":"-0.14"},{"v":0.0119894598155468,"d":"0.01"},{"v":-0.0413702239789196,"d":"-0.04"},{"v":-0.209090909090909,"d":"-0.21"},{"v":-0.0733860342555995,"d":"-0.07"},{"v":-0.113702239789196,"d":"-0.11"},{"v":-0.244664031620553,"d":"-0.24"},{"v":-0.555204216073781,"d":"-0.56"},{"v":-0.164163372859025,"d":"-0.16"},{"v":0.134457656781003,"d":"0.13"},{"v":-0.00421607378129117,"d":"-0.00"},{"v":0.0351778656126482,"d":"0.04"},{"v":-0.14743568636741,"d":"-0.15"},{"v":0.128923877668017,"d":"0.13"},{"v":-0.0898550724637681,"d":"-0.09"},{"v":-0.146376811594203,"d":"-0.15"},{"v":0.0341238471673254,"d":"0.03"},{"v":-0.0830066866947885,"d":"-0.08"},{"v":0.277733860342556,"d":"0.28"},{"v":-0.00474308300395257,"d":"-0.00"},{"v":0.0976284584980237,"d":"0.10"}]
[null,null,"Cluster_522","-","-","-","-","unknown genus","unknown species",{"v":-0.253886693017128,"d":"-0.25"},{"v":-0.00500658761528327,"d":"-0.01"},{"v":0.0654808959156785,"d":"0.07"},{"v":-0.145191040843215,"d":"-0.15"},{"v":-0.169169960474308,"d":"-0.17"},{"v":0.00474308300395257,"d":"0.00"},{"v":-0.219499341238472,"d":"-0.22"},{"v":-0.220026350461133,"d":"-0.22"},{"v":-0.0702239789196311,"d":"-0.07"},{"v":-0.304479578392622,"d":"-0.30"},{"v":-0.490382081686429,"d":"-0.49"},{"v":-0.205797101449275,"d":"-0.21"},{"v":0.0255599472990777,"d":"0.03"},{"v":0.339920948616601,"d":"0.34"},{"v":0.107184031152715,"d":"0.11"},{"v":0.24703557312253,"d":"0.25"},{"v":0.527536231884058,"d":"0.53"},{"v":-0.259758226696469,"d":"-0.26"},{"v":0.095062419762365,"d":"0.10"},{"v":0.0865612648221344,"d":"0.09"},{"v":0.169433465085639,"d":"0.17"},{"v":0.21304347826087,"d":"0.21"},{"v":0.213379887463825,"d":"0.21"},{"v":-0.0391304347826087,"d":"-0.04"},{"v":0.188932806324111,"d":"0.19"},{"v":0.239789196310935,"d":"0.24"}]
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[null,null,"Cluster_422","-","-","-","-","-","unknown species",{"v":0.9557953,"d":"0.956"},{"v":0.964004,"d":"0.964"},{"v":0.9859744,"d":"0.986"},{"v":0.91987322,"d":"0.920"},{"v":0.9938436,"d":"0.994"},{"v":0.9967766,"d":"0.997"},{"v":0.9869525,"d":"0.987"},{"v":0.9938223,"d":"0.994"},{"v":0.7186214,"d":"0.719"},{"v":0.99628327,"d":"0.996"},{"v":0.99809982,"d":"0.998"},{"v":0.9822704,"d":"0.982"},{"v":0.99896762,"d":"0.999"},{"v":0.7437185,"d":"0.744"},{"v":0.9732755,"d":"0.973"},{"v":0.8688666,"d":"0.869"},{"v":0.2641561713,"d":"0.264"},{"v":0.927419573,"d":"0.927"},{"v":0.8840744,"d":"0.884"},{"v":0.01846228,"d":"0.018"},{"v":0.9814175,"d":"0.981"},{"v":0.9635683,"d":"0.964"},{"v":0.708628,"d":"0.709"},{"v":0.8698933,"d":"0.870"},{"v":0.969658,"d":"0.970"},{"v":0.83913983,"d":"0.839"}]
[null,"OTU taxonomy is given at the phylum, class, order, family, and genus level when available, with '-' indicating that the annotation is the same than the taxonomy of the above OTU."]

{"sheet":"Table S14","index":17,"n_rows":34,"n_cols":35,"rows_kept":34}
[]
[null,"Table S14: Spearman correlation between OTU abundance et immune parameters in the Vaccinated group."]
[null,"Indice","OTU","Phylum","Class","Order","Family","Genus","species","Thrombocytes","Heterophils","Monocytes","B cells","TCRϒδ+ T  cells","Frequency of TCR1+CD8+ ϒδ T cells","Frequency of TCR1+CD8- ϒδ T cells","Frequency of ab T cells","Frequency of TCR1-CD8+ (ab) T cells","Frequency of TCR1ꟷCD4+_(ab)_T cells","Frequency of TCR1̶CD4+CD25+ (ab) T cells","Frequency of Thrombocytes","CD45 expression on Thrombocytes","CD45 expression on heterophils","MRC1L-B expression on Monocytes","CD45 expression on monocytes","MHCII expression on monocytes","Bu1 expression on B cells","IgM on B cells","TCRϒδ expression on TCRϒδ+ T cells","CD8 β expression on CD8 αβ+ TCR ϒδ+  T cells","CD8 β expression on CD8 αβ+ T cells","CD4 expression on CD4+ T cells","CD4 expression on CD4+ CD25+ T cells","CD25 expression on CD4+ CD25+ T cells","MHC II expression on B cells"]
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[null,null,"Cluster_543","-","-","-","-","Lachnospiraceae NC2004 group","unknown species",{"v":-1.41120277898393E-3,"d":"-0.00"},{"v":-0.0306122448979592,"d":"-0.03"},{"v":-0.119300911854103,"d":"-0.12"},{"v":-0.0424446374294399,"d":"-0.04"},{"v":-0.364090316977855,"d":"-0.36"},{"v":-0.333695180199739,"d":"-0.33"},{"v":-0.312201476335215,"d":"-0.31"},{"v":-0.0648067737733391,"d":"-0.06"},{"v":-0.0226877985236648,"d":"-0.02"},{"v":0.0766391663048198,"d":"0.08"},{"v":-0.000651324359531046,"d":"-0.00"},{"v":0.362896222318715,"d":"0.36"},{"v":0.0742509769865393,"d":"0.07"},{"v":0.101172383847156,"d":"0.10"},{"v":0.0643725575336518,"d":"0.06"},{"v":-0.247944201790227,"d":"-0.25"},{"v":-0.153061224489796,"d":"-0.15"},{"v":0.490990013026487,"d":"0.49"},{"v":0.321862787668259,"d":"0.32"},{"v":-0.559379070777247,"d":"-0.56"},{"v":-0.323816760746852,"d":"-0.32"},{"v":-0.196157186278767,"d":"-0.20"},{"v":-0.161419887103778,"d":"-0.16"},{"v":-0.197568389057751,"d":"-0.20"},{"v":0.0629613547546678,"d":"0.06"},{"v":0.114524533217542,"d":"0.11"}]
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[null,"OTU taxonomy is given at the phylum, class, order, family, and genus level when available, with '-' indicating that the annotation is the same than the taxonomy of the above OTU."]