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["Trial Forge: cost estimates for Time to collect"]
["Note:","1. These data are based on the 130 trials for which we could obtain full Time to collect data for the trial.  "]
[null,"2. The hourly rate is the February 2022 hourly rate for a UK National Health Service research nurse. "]
[]
[]
["Hourly rate for research nurse time",null,{"v":23.51,"d":"£23.51"}]
[]
[]
["All trials"]
[null,null,"Primary outcome total Time to collect","Secondary outcomes total Time to collect","Total Time to collect",null,"Time spent on secondaries compared to primary (ratio)",null,null,"Notional cost of primary outcome collection (£)","Notional cost of secondary outcome collection (£)","Total notional cost of outcome collection (£)"]
[null,"Median (mins)",{"$nulls":3},"Median",null,null,"Median"]
[null,"Min (mins)",{"$nulls":6},"Min"]
[null,"Max (mins)",{"$nulls":6},"Max"]
[]
[null,"Median (hours)"]
[null,"Min (hours)"]
[null,"Max (hours)"]
[]
[]
["Phase 3 trials"]
["Trial ID","Title of trial","Primary outcome total Time to collect (mins)","Secondary outcomes total Time to collect (mins)","Total Time to collect (mins)",null,"Time spent on secondaries compared to primary (ratio)",null,null,"Notional cost of primary outcome collection (£)","Notional cost of secondary outcome collection (£)","Total notional cost of outcome collection (£)"]
[41,"Foldable vs rigid lenses after phacoemulsification for cataract surgery: a randomised controlled trial",3600,40800]
[42,"Motivational counseling to reduce sitting time: a community-based randomized controlled trial in adults",9960,3154]
[43,"Assessment of the adjuvant effect of tacrolimus in the management of pemphigus vulgaris: A randomized controlled trial",276,828]
[44,"Impact of age of first exposure to Plasmodium falciparum on antibody responses to malaria in children: a randomized, controlled trial in Mozambique",3490,18322.5]
[45,"A Cluster Randomized-Controlled Trial of a Classroom-Based Drama Workshop Program to Improve Mental Health Outcomes among Immigrant and Refugee Youth in Special Classes",8325,13875]
[47,"Robotic Resistance/Assistance Training Improves Locomotor Function in Individuals Poststroke: A Randomized Controlled Study",1170,4275]
[48,"Resistance to Erythropoiesis Stimulating Agents in Patients Treated with Online Hemodiafiltration and Ultrapure Low-Flux Hemodialysis: Results from a Randomized Controlled Trial (CONTRAST)",2142,859299]
[49,"A Text Message Alcohol Intervention for Young Adult Emergency Department Patients: A Randomized Clinical Trial",91800,0]
[50,"Multidisciplinary Group Clinic Appointments: The Self-Management and Care of Heart Failure (SMAC-HF) Trial",990,17820]
[51,"Platelet-rich plasma injections for the treatment of hamstring injuries: a randomized controlled trial",48440,4760]
[52,"Influence of counseling sessions on the prevalence of breastfeeding in the first year of life: a randomized clinical trial with adolescent mothers and grandmothers",21802.5,21802.5]
[53,"Diet and physical exercise in psoriasis: a randomized controlled trial",2727,9696]
[54,"Online CBT for preschool anxiety disorders: a randomised control trial",8970,8840]
[55,"Family-based psychosocial support and education as part of pulmonary rehabilitation in COPD: a randomized controlled trial",3360,14140]
[56,"Increasing varenicline dose in smokers who do not respond to the standard dosage: a randomized clinical trial",3200,15400]
[57,"Modafinil increases the latency of response in the Hayling Sentence Completion Test in healthy volunteers: a randomised controlled trial",7680,3200]
[58,"A randomized phase III study comparing pegylated liposomal doxorubicin with capecitabine as first-line chemotherapy in elderly patients with metastatic breast cancer: results of the OMEGA study of the Dutch Breast Cancer Research Group BOOG",487.5,2340]
[59,"Transforaminal versus intra-articular facet corticosteroid injections for the treatment of cervical radiculopathy: a randomized, double-blind, controlled study",504,3360]
[60,"Simvastatin as a novel therapeutic agent for venous ulcers: a randomized, double-blind, placebo-controlled trial",2842.95,9523.8825]
[61,"Prevention of conversion to abnormal TCD with hydroxyurea in sickle cell anemia: a phase III international randomized clinical trial",23100,66000]
[63,"Interactive cognitive-motor step training improves cognitive risk factors of falling in older adults – a randomized controlled trial",1800,18090]
[64,"Tilt table therapies for patients with severe disorders of consciousness: a randomized, controlled trial",3375,6075]
[65,"Evaluation of sit-stand workstations in an office setting: a randomised controlled trial",5640,4371]
[66,"Continuous positive airway pressure with helmet versus mask in infants with bronchiolitis: An RCT",90,690]
[67,"Ultra-low-dose buprenorphine as a time-limited treatment for severe suicidal ideation: A randomized controlled trial",3520,11264]
[68,"Radiofrequency versus ethanol ablation for treating predominantly cystic thyroid nodules: A randomized clinical trial",3000,800]
[69,"Folic acid causes higher prevalence of detectable unmetabolized folic acid in serum than B-complex: A randomized clinical trial",406,406]
[70,"Early intervention and child physical health: Evidence from a Dublin-based randomized controlled trial",58250,69900]
[71,"Early sustained unresponsiveness after short-course egg oral immunotherapy: a randomized controlled study in egg-allergic children",5490,16165]
[72,"Diagnostic performance of the Bernese versus Ottawa ankle rules: Results of a randomised controlled trial",507.5,507.5]
[73,"Circuit class therapy or seven-day week therapy for increasing rehabilitation intensity of therapy after stroke (CIRCIT): a randomized controlled trial",9056,110370]
[74,"Implementation of a surgical safety checklist and postoperative outcomes: a prospective randomized controlled study",6300,42000]
[75,"Oxybutynin as a treatment for generalized hyperhidrosis: a randomized, placebo-controlled trial",620,930]
[76,"Benefits of partnered strength training for prostate cancer survivors and spouses: results from a randomized controlled trial of the Exercising Together project",3840,11616]
[77,"Calcium and vitamin D supplementation do not influence menopause-related symptoms: Results of the Women’s Health Initiative Trial",138120,587010]
[78,"Resveratrol improves treatment outcome and laboratory parameters in patients with Takayasu arteritis: A randomized double-blind and\nplacebo-controlled trial",16940,8470]
[79,"Tai Chi Exercise for Cancer-Related Fatigue in Patients With Lung Cancer Undergoing Chemotherapy: A Randomized Controlled Trial",1440,0]
[80,"Comparison of active vs. expectant management of the third stage of labor in women with low risk of postpartum hemorrhage: a randomized controlled trial",2676,8028]
[81,"Efficacy of Cognitive-Behavioral Therapy for Insomnia Combined With Antidepressant Pharmacotherapy in Patients With Comorbid Depression and Insomnia: A Randomized Controlled Trial",54000,8100]
[83,"Effect of Continuous Positive Airway Pressure on Cardiovascular Biomarkers: The Sleep Apnea Stress Randomized Controlled Trial",2677.5,30217.5]
[84,"Is dextrose prolotherapy superior to placebo for the treatment of temporomandibular joint hypermobility? A randomized clinical trial",360,270]
[85,"Should Asymptomatic Bacteriuria Be Systematically Treated in Kidney Transplant Recipients? Results From a Randomized Controlled Trial",336,2464]
[86,"Is there an effect of intranasal insulin on development and behaviour in Phelan-McDermid syndrome? A randomized, double-blind, placebo-controlled trial",9375,4687.5]
[87,"Effects of Housing First on Employment and Income of Homeless Individuals: Results of a Randomized Trial",112770,48330]
[88,"Refeeding low weight hospitalized adolescents with anorexia nervosa: a multicenter randomized controlled trial",3240,25920]
[89,"Sustained-release dexamfetamine in the treatment of chronic cocaine-dependent patients on heroin-assisted treatment: a randomised, double-blind, placebo-controlled trial",1752,43508]
[90,"Immediate versus delayed invasive intervention for non-STEMI patients: The RIDDLE-NSTEMI Study",969,17442]
[92,"Belotecan/cisplatin versus etoposide/cisplatin in previously untreated patients with extensive-stage small cell lung carcinoma: a multi-center randomized phase III trial",9420,17270]
[93,"Duration of antibiotic treatment in community-acquired pneumonia: A multicenter randomized clinical trial",624,18408]
[94,"Seven-day intensive preoperative rehabilitation for elderly patients with lung cancer: a randomized controlled trial",180,3000]
[95,"Effect of soy in men with type 2 diabetes mellitus and subclinical hypogonadism: A randomized controlled study",1400,2800]
[96,"Supported telemonitoring and glycemic control in people with type 2 diabetes: The telescot diabetes pragmatic multicenter randomized controlled trial",3210,10272]
[98,"Behavioral weight loss intervention for migraine: A randomized controlled trial",27720,22220]
[99,"Clinic and home-based behavioral intervention for obesity in pre-schoolers: A randomized trial",1670,100200]
[100,"Effects of clay art therapy on adults outpatients with major depressive disorder: A randomized controlled trial",4770,14310]
[101,"Effectiveness of irrigation with chlorhexidine after removal of mandibular third molars: A randomised controlled trial",2200,1200]
[102,"The effects of multi-disciplinary psycho-social care on socio-economic problems in cancer patients: A cluster-randomized trial",26312,92092]
[103,"Clinical effects of a pharmacist intervention in acute wards: A randomized controlled trial",29880,1494]
[105,"Reducing trunk compensation in stroke survivors: A randomized crossover trial comparing visual and force feedback modalities",225,1027.5]
[106,"Effect of Erythropoietin in patients with acute myocardial infarction: five-year results of the REVIVAL-3 trial",6210,15180]
[107,"Does azithromycin given to women in labour decrease ocular bacterial infection in neonates? A double-blind, randomized trial",4145,4145]
[108,"Comparison of 3D laparoscopic gastrectomy with a 2D procedure for gastric cancer: A phase 3 randomized controlled trial",1314,19710]
[111,"Effect of myofascial techniques for treatment of persistent arm pain after breast cancer treatment: Randomized controlled trial",450,1950]
[112,"Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: The FINGER trial",340200,343980]
[113,"Mercaptopurine versus placebo to prevent recurrence of Crohn’s disease after surgical resection (TOPPIC): A multicentre, double-blind randomised controlled trial",44640,89940]
[114,"Work-focused cognitive behavioural intervention for psychological complaints in patients on sick leave due to work-related stress: Results from a randomized controlled trial",2934,4401]
[115,"Efficacy of guided self-help behavioural activation and physical acivity for depression: A randomized controlled trial",708,1180]
[117,"Acupressure, sleep, and quality of life in institutionalized older adults: A randomized controlled clinical trial",1395,1627.5]
[119,"Repetitive TMS to augment cognitive processing therapy in combat veterans of recent conflicts with PTSD: A randomized clinical trial",27810,3090]
[120,"Minimally invasive versus abdominal radical hysterectomy for cervical cancer",3943.75,246247.75]
[121,"Classroom-based physical activity improves children’s math achievement – A randomized controlled trial",45450,200990]
[122,"Effect of a low-intensity PSA-based screening based intervention on prostate cancer mortality: The CAP randomized clinical trial",0,81409972]
[123,"Prophylaxis of postoperative nausea and vomiting after cardiac surgery in high-risk patients: A randomized controlled study ",7530,4518]
[124,"Effects of long-term norfloxacin therapy in patients with advanced cirrhosis ",8730,37830]
[125,"Cervical ripening balloon with and without oxytocin in multiparas: A randomized controlled trial ",585,2340]
[126,"Self-tracking of physical activity in people with type 2 diabetes ",504,6624]
[127,"An 18-mo randomized, double-blind, placebo-controlled trial of DHA-rich fish oil to prevent age-related cognitive decline in cognitively normal older adults",644800,21762]
[128,"Effects of a combined physical and psychosocial training for children with cancer: A randomized controlled trial",6195,21682.5]
[132,"Managing risk of non-communicable diseases in women with bulimia nervosa or binge eating disorders: A randomized trial with 12 months follow-up",53300,166460]
[133,"Communication-based interventions for increasing influenza vaccination rates among Aboriginal children: A randomised controlled trial",5534,5534]
[134,"Garlic extract favourably modifies markers of endothelial function in obese patients – randomized double blind placebo-controlled nutritional intervention",1288,2024]
[135,"Bag-Mask Ventilation during Tracheal Intubation\nof Critically Ill Adults",1203,44912]
[136,"Design of the SHAPE-2 study: the effect of physical activity, in addition to weight loss, on biomarkers of postmenopausal breast cancer risk",2430,41310]
[137,"Satisfactory analgesia with minimal emesis in day surgeries: a randomised controlled trial of morphine versus hydromorphone",2010,12864]
[138,"Effects of home reading training on reading and quality of life in AMD-a randomized and controlled study",1480,8269.5]
[140,"A randomized trial of trigger point dry needling versus sham needling for chronic tension-type headache",1449,7245]
[141,"Cost-effectiveness and quality of life of a diet intervention postpartum: 2-year results from a randomized controlled trial",660,3685]
[142,"Discontinuing cotrimoxazole preventive therapy in HIV-infected adults who are stable on antiretroviral treatment in Uganda (COSTOP): A randomised placebo-controlled trial",13080,20710]
[143,"Goal-oriented cognitive rehabilitation for early-stage Alzheimer's and related dementias: the GREAT RCT",28500,44650]
[144,"Lung protective ventilation during pulmonary resection in children: a prospective, single-centre, randomised controlled trial",3420,1368]
[145,"Cuff-assisted versus cap-assisted colonoscopy for adenoma detection: results of a randomized study",2133,10665]
[146,"Selective laser trabeculoplasty versus drops for newly diagnosed ocular hypertension and glaucoma: the LiGHT RCT",7180,233709]
[147,"Inflammatory markers response to citrulline supplementation in patients with non-alcoholic fatty liver disease: a randomized, double blind, placebo-controlled, clinical trial",3500,3000]
[148,"Effect of manual physiotherapy in homogeneous individuals with subacromial shoulder impingement: A randomized controlled trial",1380,1656]
[149,"Adjuvant Chemotherapy plus Radiation for Locally Advanced Endometrial Cancer",44160,161920]
[150,"Procalcitonin-Guided Treatment on Duration of Antibiotic Therapy and Cost in Septic Patients (PRODA): a Multi-Center Randomized Controlled Trial",52,260]
[151,"Levothyroxine in Women with Thyroid Peroxidase Antibodies before Conception",2856,71400]
[152,"Pre-pregnancy and early pregnancy calcium supplementation among women at high risk of pre-eclampsia: a multicentre, double-blind, randomised, placebo-controlled trial",4065,117885]
[153,"White Sweet Potato as Meal Replacement for Overweight White-Collar Workers: A Randomized Controlled Trial",360,2208]
[154,"Group singing improves depression and life quality in patients with stable COPD: a randomized community-based trial in China",2040,480]
[]
[null,"Median (mins)",{"$nulls":3},"Median",null,null,"Median"]
[null,"Min (mins)",{"$nulls":6},"Min"]
[null,"Max (mins)",{"$nulls":6},"Max"]
[]
[null,"Median (hours)"]
[null,"Min (hours)"]
[null,"Max (hours)"]
[]
[]
["Core outcome set trials"]
["Trial ID","Title of trial","Primary outcome total Time to collect (mins)","Secondary outcomes total Time to collect (mins)","Total Time to collect (mins)",null,"Time spent on secondaries compared to primary (ratio)",null,null,"Notional cost of primary outcome collection","Notional cost of secondary outcome collection","Total notional cost of outcome collection"]
[5,"Direct comparison of treatment responses, remission rates, and drug adherence in patients with rheumatoid arthritis treated with adalimumab, etanercept, or infliximab: results from 8 years of surveillance of clinical practice in the DANBIO registry.",0,25200]
[6,"Effects of Atorvastatin on Disease Activity and HDL Cholesterol Function in Patients With Rheumatoid Arthritis",490,2500]
[7,"A Comparison of Methotrexate Alone or Combined to Infliximab or to Pulse Methylprednisolone in Early Rheumatoid Arthritis: A Magnetic Resonance Imaging Study",5940,21296]
[9,"Treatment of Early RA: Minocycline in Combination With Methotrexate vs Methotrexate Alone",38220,57330]
[11,"Comparison of MTX+ anti-TNF to MTX+ conventional DMARDs in patients with early rheumatoid arthritis who failed MTX alone",1461,324.342]
[12,"Switching Anti-TNF-Alpha Agents in Rheumatoid Arthritis (RA)",702,2281.5]
[30,"TNF-blocking Therapy in Combination With Disease-modifying Antirheumatic Drugs in Early Rheumatoid Arthritis (NEO-RACo)",120285,2970]
[31,"Success of Tocilizumab in RA Patients With Remission Induction and Sustained Efficacy After Discontinuation (SURPRISE)",2330,20387.5]
[32,"Spacing of TNF-blocker Injections in Rheumatoid Arthritis Study (STRASS)",11097,45792.25]
[33,"Optimal management of rheumatoid arthritis patients requiring biologic therapy (ORBIT)",5900,20650]
[34,"Effectiveness in daily practice of different treatment strategies for early rheumatoid arthritis",15349.5,9475]
[35,"Improvement in insulin resistance is greater when infliximab is added to methotrexate during intensive treatment of early rheumatoid arthritis-results from the IDEA study.",1975,11613]
[36,"Study of Two Different Starting Doses of Methotrexate When Starting Treatment in Rheumatoid Arthritis (DMIRA)",2700,350]
[37,"Study of Different Doses of Folic Acid in Combination With Methotrexate in Rheumatoid Arthritis (FOLVARI)",2500,3000]
[38,"Leflunomide Versus Sulfasalazine/Methotrexate in Rheumatoid Arthritis:an Ultrasound/Magnetic Resonance Imaging Study",45,90]
[39,"RA Denosumab on bone microstructure study ",40,1878.4]
[161,"Combination Treatment With Methotrexate, Cyclosporine, and Intraarticular Betamethasone Compared With Methotrexate and Intraarticular Betamethasone in Early Active Rheumatoid Arthritis Early Active Rheumatoid Arthritis",14400,64320]
[]
[null,"Median (mins)",{"$nulls":3},"Median",null,null,"Median"]
[null,"Min (mins)",{"$nulls":6},"Min"]
[null,"Max (mins)",{"$nulls":6},"Max"]
[]
[null,"Median (hours)"]
[null,"Min (hours)"]
[null,"Max (hours)"]
[]
[]
["Public health trials"]
["Trial ID","Title of trial","Primary outcome total Time to collect (mins)","Secondary outcomes total Time to collect (mins)","Total Time to collect (mins)",null,"Time spent on secondaries compared to primary (ratio)",null,null,"Notional cost of primary outcome collection","Notional cost of secondary outcome collection","Total notional cost of outcome collection"]
[1,"PRENACEL - a mHealth messaging system to complement antenatal care: a cluster randomized trial",15125,30250]
[2,"Effects of web-based stress and depression literacy intervention on improving symptoms and knowledge of depression among workers: A randomized controlled trial",41715,63036]
[3,"Theory-based modifications of an advanced notification letter improves screening for bowel cancer in men: A randomised controlled trial",138240,368640]
[13,"A randomized, controlled trial to increase discussion of breast cancer in primary care",16350,22890]
[15,"Metabolic syndrome from adolescence to early adulthood: effect of infancy-onset dietary counseling of low saturated fat: the Special Turku Coronary Risk Factor Intervention Project (STRIP)",21231.504,106195.752]
[16,"Effectiveness of a group diabetes education programme in under-served communities in South Africa: a pragmatic cluster randomized controlled trial",36110,115395]
[17,"Improving feeding and growth of HIV-positive children through nutrition training of frontline health workers in Tanga, Tanzania",363168,242112]
[18,"Family-centered brief intervention for reducing obesity and cardiovascular disease risk: A randomized controlled trial",48000,19200]
[19,"Effectiveness of a walking programme to support adults with intellectual disabilities to increase physical activity: walk well cluster-randomised controlled trial.",3570,29835]
[20,"Intervention of childhood and adolescents obesity in Shantou city",410,4592]
[21,"A block randomized controlled trial of a brief smoking cessation counselling and advice through short message service on participants who joined the Quit to Win Contest in Hong Kong",3009,48144]
[22,"Brief report: A randomized controlled trial examining peer support and behavioral weight loss treatment",1845,3997.5]
[24,"Self-Expansion is Associated with Better Adherence and Obesity Treatment Outcomes in Adults",1072,37252]
[25,"The Effectiveness of a Web-Based Computer-Tailored Intervention on Workplace Sitting: A Randomized Controlled Trial",47925,7987.5]
[26,"Effects of Awareness Material on Suicide-Related Knowledge and the Intention to Provide Adequate Help to Suicidal Individuals",546,546]
[27,"A Computerized Lifestyle Application to Promote Multiple Health Behaviors at the Workplace: Testing Its Behavioral and Psychological Effects",21840,3920]
[29,"Motivational interviewing and self-determination theory in a web-based computer tailored physical activity intervention: A randomized controlled trial",193590,451710]
[]
[null,"Median (mins)",{"$nulls":3},"Median",null,null,"Median"]
[null,"Min (mins)",{"$nulls":6},"Min"]
[null,"Max (mins)",{"$nulls":6},"Max"]
[]
[null,"Median (hours)"]
[null,"Min (hours)"]
[null,"Max (hours)"]