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["Table S12. Ingenuity Pathway Analysis (IPA)-top enriched canonical pathways for transcripts that display significant 3' UTR shortening at day 21 as compared to day 14 post-fracture "]
["Ingenuity Canonical Pathways"," -log(p-value)","Ratio","Molecules"]
["Integrin Signaling",8.29,0.0986,"ACTB,ACTN4,ACTR2,Arf2,CAPN2,CAPNS1,Cdc42,ITGA10,ITGA5,LIMS1,MAP2K4,MAPK3,MYL12A,PAK1,PFN1,RAC1,RHOA,TLN1,TSPAN7,VCL,WIPF1"]
["Leukocyte Extravasation Signaling",6.13,0.0881,"ACTB,ACTN4,CD44,CTNNB1,CXCL12,CYBB,EZR,GNAI2,GNAI3,MAP2K4,MSN,PECAM1,RAC1,RDX,RHOA,VCL,WIPF1"]
["Remodeling of Epithelial Adherens Junctions",5.83,0.147,"ACTB,ACTN4,ACTR2,CTNNB1,RAB5A,RAB5B,RAB5C,RAB7A,TUBB,VCL"]
["Sumoylation Pathway",5.76,0.117,"ARHGDIB,Cdc42,CEBPA,CTBP1,EP300,ETS1,MAP2K4,NFKBIA,RAC1,RHOA,SAE1,SP3"]
["RhoGDI Signaling",5.58,0.0847,"ACTB,ACTR2,ARHGDIB,CD44,Cdc42,EP300,EZR,GNAI2,GNAI3,ITGA5,MSN,MYL12A,PAK1,RAC1,RDX,RHOA"]
["Protein Kinase A Signaling",5.33,0.06,"ADD1,Calm1 (includes others),CDC23,CHUK,CTNNB1,DUSP1,DUSP6,GNAI2,GNAI3,GYS1,H1-0,MAPK3,MYL12A,NFATC3,NFKBIA,PDE1B,PDE2A,PPP3R1,PRKAR1A,PTP4A1,RHOA,TGFBR2,YWHAH,YWHAZ"]
["Actin Cytoskeleton Signaling",5.17,0.0749,"ACTB,ACTN4,ACTR2,CSK,EZR,ITGA5,MAPK3,MSN,MYH9,MYL12A,PAK1,PFN1,RAC1,RDX,RHOA,TLN1,VCL"]
["Signaling by Rho Family GTPases",5.13,0.0711,"ACTB,ACTR2,Cdc42,CDC42EP3,CYBB,EZR,GNAI2,GNAI3,ITGA5,MAP2K4,MAPK3,MSN,MYL12A,PAK1,RAC1,RDX,RHOA,WIPF1"]
["FAK Signaling",4.92,0.106,"ACTB,CAPN2,CAPNS1,CSK,GIT2,ITGA5,MAPK3,PAK1,RAC1,TLN1,VCL"]
["Paxillin Signaling",4.76,0.102,"ACTB,ACTN4,CSK,GIT2,ITGA10,ITGA5,MAP2K4,PAK1,RAC1,TLN1,VCL"]
["Ephrin B Signaling",4.71,0.125,"CAP1,CTNNB1,CXCL12,GNAI2,GNAI3,MAPK3,PAK1,RAC1,RHOA"]
["Regulation of Cellular Mechanics by Calpain Protease",4.62,0.122,"ACTN4,CAPN2,CAPNS1,CAST,EZR,ITGA5,MAPK3,TLN1,VCL"]
["Cardiac Hypertrophy Signaling",4.28,0.0667,"Calm1 (includes others),Cdc42,EP300,GNAI2,GNAI3,MAP2K4,Map3k7,MAPK3,MEF2A,MYL12A,PPP3R1,PRKAR1A,RAC1,RHOA,SRF,TGFBR2"]
["Clathrin-mediated Endocytosis Signaling",4.21,0.0725,"ACTB,ACTR2,AP1S1,GAK,ITGA5,LDLR,PICALM,PPP3R1,RAB5A,RAB5B,RAB5C,RAB7A,RAC1,TFRC"]
["Regulation of Actin-based Motility by Rho",4.2,0.0971,"ACTB,ACTR2,Cdc42,ITGA5,MYL12A,PAK1,PFN1,RAC1,RHOA,WIPF1"]
["Sertoli Cell-Sertoli Cell Junction Signaling",4.19,0.0722,"ACTB,ACTN4,CTNNB1,EPB41,ITGA5,MAP2K4,Map3k7,MAPK3,PRKAR1A,RAC1,SPTBN1,TUBB,VCL,YBX3"]
["Germ Cell-Sertoli Cell Junction Signaling",4.16,0.076,"ACTB,ACTN4,Cdc42,CTNNB1,MAP2K4,Map3k7,MAPK3,PAK1,RAC1,RHOA,TGFBR2,TUBB,VCL"]
["Epithelial Adherens Junction Signaling",4.04,0.0789,"ACTB,ACTN4,ACTR2,CTNNB1,LMO7,MYH9,RAC1,RHOA,SNAI2,TGFBR2,TUBB,VCL"]
["Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes",3.94,0.1,"Calm1 (includes others),CHUK,MAP2K4,MAPK3,NFATC3,NFKBIA,PPP3R1,RAC1,TGFBR2"]
["Caveolar-mediated Endocytosis Signaling",3.84,0.11,"ACTB,ARCN1,COPA,ITGA10,ITGA5,RAB5A,RAB5B,RAB5C"]
["B Cell Receptor Signaling",3.79,0.0699,"BCL6,Calm1 (includes others),CHUK,CSK,ETS1,INPPL1,MAP2K4,Map3k7,MAPK3,NFATC3,NFKBIA,PPP3R1,RAC1"]
["Hepatic Fibrosis Signaling Pathway",3.79,0.0529,"Calm1 (includes others),Cdc42,CHUK,COL10A1,CTNNB1,CYBB,GNAI2,GNAI3,IRAK2,ITGA5,MAP2K4,MAPK3,MYL12A,NFKBIA,PRKAR1A,RAC1,RHOA,SDHA,TFRC,TGFBR2"]
["fMLP Signaling in Neutrophils",3.77,0.0862,"ACTR2,Calm1 (includes others),CYBB,GNAI2,GNAI3,MAPK3,NFATC3,NFKBIA,PPP3R1,RAC1"]
["Semaphorin Neuronal Repulsive Signaling Pathway",3.76,0.0791,"CD44,ITGA5,MAP2K4,MYL12A,PAK1,PLXND1,PRKAR1A,RAC1,RHOA,SEMA3F,SEMA6D"]
["ILK Signaling",3.7,0.0684,"ACTB,ACTN4,Cdc42,CTNNB1,FERMT2,LIMS1,MAP2K4,MAPK3,MYH9,RAC1,RHOA,SNAI2,VCL"]
["Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis",3.65,0.0642,"ALPL,Calm1 (includes others),CHUK,CSF1,CTNNB1,ITGA5,LRP1,MAP2K4,MAPK3,NFATC3,NFKBIA,PPP3R1,SOST,TAB2"]
["Tight Junction Signaling",3.63,0.0714,"ACTB,CEBPA,CTNNB1,EPB41,MYH9,PRKAR1A,RAC1,RHOA,TGFBR2,VAPA,VCL,YBX3"]
["CD28 Signaling in T Helper Cells",3.62,0.0826,"ACTR2,Calm1 (includes others),CHUK,CSK,MAP2K4,NFATC3,NFKBIA,PAK1,PPP3R1,RAC1"]
["RAR Activation",3.61,0.067,"ACTB,ARID1A,CSK,DHRS3,DUSP1,EP300,MAP2K4,PRKAR1A,RAC1,RARG,SMARCD1,SMARCD2,SNW1"]
["RhoA Signaling",3.56,0.0813,"ACTB,ACTR2,CDC42EP3,EZR,MSN,MYL12A,PFN1,RDX,RHOA,SEMA3F"]
["ERK/MAPK Signaling",3.44,0.0644,"DUSP1,DUSP6,ELF1,ETS1,ITGA5,MAPK3,PAK1,PRKAR1A,RAC1,SRF,TLN1,YWHAH,YWHAZ"]
["Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis",3.42,0.0541,"Calm1 (includes others),CEBPA,CHUK,CSF1,CTNNB1,CXCL12,IRAK2,LRP1,MAP2K4,MAPK3,NFATC3,NFKBIA,PPP3R1,RAC1,RHOA,SOST,TRAF1"]
["T Cell Receptor Signaling",3.4,0.0849,"Calm1 (includes others),CHUK,CSK,MAP2K4,MAPK3,NFATC3,NFKBIA,PPP3R1,RAC1"]
["Taurine Biosynthesis",3.36,1,"CDO1,CSAD"]
["Gαq Signaling",3.3,0.0701,"Calm1 (includes others),Cdc42,CHUK,CSK,GYS1,MAPK3,NFATC3,NFKBIA,PPP3R1,RAC1,RHOA"]
["4-1BB Signaling in T Lymphocytes",3.3,0.156,"CHUK,MAP2K4,MAPK3,NFKBIA,TRAF1"]
["PI3K/AKT Signaling",3.27,0.0652,"CHUK,CTNNB1,GYS1,IL10RB,INPPL1,ITGA5,LIMS1,MAPK3,MCL1,NFKBIA,YWHAH,YWHAZ"]
["RANK Signaling in Osteoclasts",3.25,0.0899,"Calm1 (includes others),CHUK,MAP2K4,Map3k7,MAPK3,NFKBIA,PPP3R1,TAB2"]
["IL-1 Signaling",3.15,0.087,"CHUK,GNAI2,GNAI3,IRAK2,MAP2K4,NFKBIA,PRKAR1A,TAB2"]
["Endocannabinoid Developing Neuron Pathway",3.14,0.0783,"AKT1S1,CTNNB1,GNAI2,GNAI3,MAP2K4,MAPK3,PRKAR1A,RAC1,RHOA"]
["Senescence Pathway",3.12,0.0545,"Calm1 (includes others),CAPN2,CAPNS1,CDC23,CHUK,ELF1,EP300,ETS1,ING1,MAP2K4,MAPK3,NFATC3,PPP3R1,SQSTM1,TGFBR2"]
["Rac Signaling",2.98,0.0744,"ACTR2,CD44,CYBB,ITGA5,MAP2K4,MAPK3,PAK1,RAC1,RHOA"]
["Macropinocytosis Signaling",2.97,0.0921,"ACTN4,CSF1,ITGA5,PAK1,RAB5A,RAC1,RHOA"]
["GP6 Signaling Pathway",2.88,0.072,"ADAM10,Calm1 (includes others),COL10A1,COL12A1,COL24A1,COL6A1,COL6A3,RAC1,TLN1"]
["April Mediated Signaling",2.84,0.125,"CHUK,MAP2K4,NFATC3,NFKBIA,TRAF1"]
["B Cell Activating Factor Signaling",2.8,0.122,"CHUK,MAP2K4,NFATC3,NFKBIA,TRAF1"]
["LPS-stimulated MAPK Signaling",2.74,0.0843,"CHUK,MAP2K4,MAPK3,NFKBIA,PAK1,RAC1,SRF"]
["Necroptosis Signaling Pathway",2.74,0.0637,"CAPN2,CAPNS1,CHUK,CYBB,PGAM5,PPP3R1,SLC25A13,TAB2,TIMM17A,VDAC1"]
["Glucocorticoid Receptor Signaling",2.71,0.0433,"ACTB,ARID1A,CEBPA,CHUK,DUSP1,EP300,FKBP4,HSPA4,IL10RB,MAP2K4,MAPK3,NFATC3,NFKBIA,PPP3R1,PTGES3,RAC1,SMARCD1,SMARCD2,TGFBR2,YWHAH"]
["Cardiac Hypertrophy Signaling (Enhanced)",2.69,0.0423,"Calm1 (includes others),CHUK,CTNNB1,CYBB,EP300,GNAI2,GNAI3,IL10RB,ITGA5,MAP2K4,Map3k7,MAPK3,MEF2A,NFATC3,PDE1B,PDE2A,PPP3R1,PRKAR1A,RHOA,SRF,TGFBR2"]
["Molecular Mechanisms of Cancer",2.67,0.045,"Cdc42,CDK8,CTNNB1,EP300,GNAI2,GNAI3,ITGA5,LRP1,MAP2K4,MAPK3,MAX,NFKBIA,PAK1,PRKAR1A,RAC1,RHOA,TAB2,TGFBR2"]
["Ephrin Receptor Signaling",2.65,0.0582,"ACTR2,ADAM10,CXCL12,GNAI2,GNAI3,ITGA5,MAPK3,PAK1,RAC1,RHOA,WIPF1"]
["Opioid Signaling Pathway",2.64,0.0526,"Calm1 (includes others),CTNNB1,EP300,GNAI2,GNAI3,MAP2K4,MAPK3,NFKBIA,PDE1B,PPP3R1,PRKAR1A,RAC1,SRF"]
["CD40 Signaling",2.62,0.0923,"CHUK,FCER2,MAP2K4,MAPK3,NFKBIA,TRAF1"]
["Acetate Conversion to Acetyl-CoA",2.59,0.5,"ACSL1,ACSS2"]
["Synaptogenesis Signaling Pathway",2.58,0.0481,"ACTR2,Calm1 (includes others),CTNNB1,LRP1,MAPK3,PAK1,PRKAR1A,RAB5A,RAB5B,RAB5C,RAC1,RHOA,SHC2,THBS1,TLN1"]
["Agranulocyte Adhesion and Diapedesis",2.58,0.057,"ACTB,CXCL12,EZR,GNAI2,GNAI3,ITGA5,MSN,MYH9,PECAM1,Ppbp,RDX"]
["CXCR4 Signaling",2.54,0.0599,"Cdc42,CXCL12,GNAI2,GNAI3,MAP2K4,MAPK3,MYL12A,PAK1,RAC1,RHOA"]
["Endocannabinoid Cancer Inhibition Pathway",2.48,0.0629,"AKT1S1,CTNNB1,GNAI2,GNAI3,MAP2K4,MAPK3,PRKAR1A,RHOA,SNAI2"]
["Sphingosine-1-phosphate Signaling",2.48,0.0684,"ASAH1,Cdc42,GNAI2,GNAI3,MAPK3,RAC1,RHOA,S1PR1"]
["TNFR2 Signaling",2.47,0.133,"CHUK,MAP2K4,NFKBIA,TRAF1"]
["cAMP-mediated signaling",2.46,0.0524,"Calm1 (includes others),DUSP1,DUSP6,GNAI2,GNAI3,MAPK3,PDE1B,PDE2A,PKIG,PPP3R1,PRKAR1A,S1PR1"]
["p38 MAPK Signaling",2.46,0.0678,"DUSP1,IRAK2,MAP2K4,MAX,MEF2A,SRF,TAB2,TGFBR2"]
["Agrin Interactions at Neuromuscular Junction",2.46,0.0857,"ACTB,AGRN,MAP2K4,MAPK3,PAK1,RAC1"]
["Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes",2.44,0.0745,"ACTB,ACTR2,EZR,MAPK3,PAK1,RAC1,TLN1"]
["HGF Signaling",2.41,0.0667,"ELF1,ETS1,ITGA5,MAP2K4,Map3k7,MAPK3,PAK1,RAC1"]
["Melatonin Signaling",2.39,0.0833,"Calm1 (includes others),GNAI2,GNAI3,MAP2K4,MAPK3,PRKAR1A"]
["Estrogen Receptor Signaling",2.38,0.0457,"CDK8,CTBP1,DDX5,EP300,GNAI2,GNAI3,MAPK3,MED13L,MED16,MYL12A,PAK1,PRKAR1A,RHOA,SHC2,THRAP3"]
["Axonal Guidance Signaling",2.38,0.0405,"ACTR2,ADAM10,CXCL12,GNAI2,GNAI3,ITGA5,MAPK3,MYL12A,NFATC3,PAK1,PFN1,PLXND1,PPP3R1,PRKAR1A,RAC1,RHOA,SEMA3F,SEMA6D,TUBB,WIPF1"]
["Calcium Signaling",2.36,0.0534,"ASPH,ATP2B1,Calm1 (includes others),EP300,MAPK3,MEF2A,MYH9,NFATC3,PPP3R1,PRKAR1A,Tpm4"]
["Amyotrophic Lateral Sclerosis Signaling",2.36,0.0722,"CAPN2,CAPNS1,PAK1,RAB5A,RAB5B,RAB5C,RAC1"]
["Phagosome Maturation",2.33,0.0596,"ATP6AP1,ATP6V1D,CYBB,LAMP2,RAB5A,RAB5B,RAB5C,RAB7A,TUBB"]
["Systemic Lupus Erythematosus In T Cell Signaling Pathway",2.31,0.0449,"AKT1S1,BCL6,CD44,Cdc42,ELF1,EZR,GNAI2,GNAI3,MAP2K4,MAPK3,MSN,PPP3R1,RAC1,RDX,RHOA"]
["Lymphotoxin β Receptor Signaling",2.3,0.0943,"CHUK,EP300,MAPK3,NFKBIA,TRAF1"]
["Apoptosis Signaling",2.29,0.07,"CAPN2,CAPNS1,CHUK,MAP2K4,MAPK3,MCL1,NFKBIA"]
["Toll-like Receptor Signaling",2.28,0.0789,"CHUK,IRAK2,MAP2K4,NFKBIA,TAB2,TRAF1"]
["Hepatic Fibrosis / Hepatic Stellate Cell Activation",2.21,0.0538,"COL10A1,COL12A1,COL24A1,COL6A1,COL6A3,CSF1,IGFBP4,KLF6,MYH9,TGFBR2"]
["Gα12/13 Signaling",2.19,0.0611,"CHUK,CTNNB1,MAP2K4,MAPK3,MEF2A,MYL12A,NFKBIA,RHOA"]
["Renal Cell Carcinoma Signaling",2.17,0.075,"ARNT,EP300,ETS1,MAPK3,PAK1,RAC1"]
["Chemokine Signaling",2.17,0.075,"Calm1 (includes others),CXCL12,GNAI2,GNAI3,MAPK3,RHOA"]
["Osteoarthritis Pathway",2.15,0.05,"ACVRL1,ALPL,ANKH,ANXA5,CHUK,COL10A1,CTNNB1,ITGA5,LRP1,RAC1,TGFBR2"]
["Actin Nucleation by ARP-WASP Complex",2.15,0.0741,"ACTR2,Cdc42,ITGA5,RAC1,RHOA,WIPF1"]
["MSP-RON Signaling In Cancer Cells Pathway",2.13,0.0597,"ARNT,CTNNB1,ELF1,ETS1,MAPK3,NFKBIA,YWHAH,YWHAZ"]
["PEDF Signaling",2.12,0.0732,"CHUK,MAPK3,NFKBIA,RAC1,RHOA,SRF"]
["Apelin Adipocyte Signaling Pathway",2.12,0.0732,"CYBB,GNAI2,GNAI3,GSTZ1,MAPK3,PRKAR1A"]
["Semaphorin Signaling in Neurons",2.07,0.0833,"Cdc42,MAPK3,PAK1,RAC1,RHOA"]
["Sirtuin Signaling Pathway",2.05,0.0447,"ACLY,ACSS2,ADAM10,ATG4A,DUSP6,GABARAP,GTF3C2,H1-0,MAPK3,SDHA,SIRT2,TIMM17A,VDAC1"]
["iCOS-iCOSL Signaling in T Helper Cells",2.05,0.0631,"Calm1 (includes others),CHUK,CSK,NFATC3,NFKBIA,PPP3R1,RAC1"]
["Induction of Apoptosis by HIV1",2.04,0.082,"CHUK,MAP2K4,NFKBIA,SLC25A13,TRAF1"]
["Superpathway of Inositol Phosphate Compounds",2.02,0.0503,"ALPL,CA3,DUSP1,INPP5A,INPPL1,NUDT4,PGAM5,PIP4P1,PPFIA1,PPIP5K2"]
["IL-8 Signaling",2,0.05,"Cdc42,CHUK,CYBB,GNAI2,GNAI3,IRAK2,MAP2K4,MAPK3,RAC1,RHOA"]
["Apelin Endothelial Signaling Pathway",1.97,0.0609,"ARNT,Calm1 (includes others),GNAI2,GNAI3,MAP2K4,MAPK3,MEF2A"]
["GNRH Signaling",1.95,0.052,"Calm1 (includes others),GNAI2,GNAI3,MAP2K4,Map3k7,MAPK3,PAK1,PRKAR1A,RAC1"]
["Tec Kinase Signaling",1.95,0.052,"ACTB,Cdc42,GNAI2,GNAI3,ITGA5,MAP2K4,PAK1,RAC1,RHOA"]
["Polyamine Regulation in Colon Cancer",1.92,0.13,"CTNNB1,MAX,OAZ1"]
["Cholecystokinin/Gastrin-mediated Signaling",1.89,0.0588,"Cdc42,MAP2K4,MAPK3,MEF2A,RAC1,RHOA,SRF"]
["Death Receptor Signaling",1.89,0.0652,"ACTB,ARHGDIB,CHUK,MAP2K4,NFKBIA,TNKS2"]
["IL-22 Signaling",1.87,0.125,"IL10RB,MAP2K4,MAPK3"]
["TCA Cycle II (Eukaryotic)",1.87,0.125,"IDH3A,IDH3B,SDHA"]
["Role of NFAT in Regulation of the Immune Response",1.84,0.0497,"Calm1 (includes others),CHUK,GNAI2,GNAI3,MAPK3,MEF2A,NFATC3,NFKBIA,PPP3R1"]
["iNOS Signaling",1.84,0.0889,"Calm1 (includes others),CHUK,IRAK2,NFKBIA"]
["Reelin Signaling in Neurons",1.84,0.0574,"ACTR2,ITGA5,MAP2K4,MAPK3,PAFAH1B2,RAC1,RHOA"]
["α-Adrenergic Signaling",1.82,0.0632,"Calm1 (includes others),GNAI2,GNAI3,GYS1,MAPK3,PRKAR1A"]
["Role of NFAT in Cardiac Hypertrophy",1.81,0.0467,"Calm1 (includes others),EP300,GNAI2,GNAI3,MAP2K4,MAPK3,MEF2A,PPP3R1,PRKAR1A,TGFBR2"]
["FAT10 Cancer Signaling Pathway",1.81,0.087,"CHUK,CTNNB1,NFKBIA,TGFBR2"]
["CCR3 Signaling in Eosinophils",1.8,0.0565,"Calm1 (includes others),GNAI2,GNAI3,MAPK3,PAK1,RAC1,RHOA"]
["Small Cell Lung Cancer Signaling",1.78,0.0704,"CHUK,MAX,NFKBIA,PIAS3,TRAF1"]
["nNOS Signaling in Neurons",1.77,0.0851,"Calm1 (includes others),CAPN2,CAPNS1,PPP3R1"]
["Ephrin A Signaling",1.77,0.0851,"ADAM10,PAK1,RAC1,RHOA"]
["PKCθ Signaling in T Lymphocytes",1.77,0.0516,"CHUK,MAP2K4,Map3k7,MAPK3,NFATC3,NFKBIA,PPP3R1,RAC1"]
["Ferroptosis Signaling Pathway",1.76,0.0556,"Arf2,CYBB,EMP1,MAPK3,SLC1A5,SQSTM1,TFRC"]
["3-phosphoinositide Degradation",1.76,0.0513,"ALPL,CA3,DUSP1,INPPL1,NUDT4,PGAM5,PIP4P1,PPFIA1"]
["Calcium Transport I",1.75,0.2,"ANXA5,ATP2B1"]
["VEGF Signaling",1.74,0.0606,"ACTB,ACTN4,ARNT,EIF1AX,MAPK3,VCL"]
["Production of Nitric Oxide and Reactive Oxygen Species in Macrophages",1.73,0.0476,"Cdc42,CHUK,CYBB,MAP2K4,Map3k7,MAPK3,NFKBIA,RAC1,RHOA"]
["Glioma Invasiveness Signaling",1.73,0.0685,"CD44,Cdc42,MAPK3,RAC1,RHOA"]
["Cell Cycle: G2/M DNA Damage Checkpoint Regulation",1.71,0.0816,"EP300,FBXL5,YWHAH,YWHAZ"]
["Myc Mediated Apoptosis Signaling",1.68,0.08,"CHUK,MAX,MCL1,PRKAR1A"]
["TNFR1 Signaling",1.68,0.08,"CHUK,MAP2K4,NFKBIA,PAK1"]
["Amyloid Processing",1.68,0.08,"CAPN2,CAPNS1,MAPK3,PRKAR1A"]
["Cellular Effects of Sildenafil (Viagra)",1.68,0.0534,"ACTB,Calm1 (includes others),MYH9,MYL12A,PDE1B,PDE2A,PRKAR1A"]
["Methylthiopropionate Biosynthesis",1.68,1,"ADI1"]
["Acetyl-CoA Biosynthesis III (from Citrate)",1.68,1,"ACLY"]
["Adenine and Adenosine Salvage VI",1.68,1,"ADK"]
["IGF-1 Signaling",1.65,0.0577,"IGFBP4,MAPK3,PRKAR1A,SRF,YWHAH,YWHAZ"]
["PAK Signaling",1.61,0.0566,"ITGA5,MAP2K4,MAPK3,MYL12A,PAK1,RAC1"]
["Gap Junction Signaling",1.61,0.0455,"ACTB,CTNNB1,GNAI2,GNAI3,MAPK3,PPP3R1,PRKAR1A,SP3,TUBB"]
["Androgen Signaling",1.6,0.0515,"Calm1 (includes others),EP300,GNAI2,GNAI3,HSPA4,MAPK3,PRKAR1A"]
["PTEN Signaling",1.6,0.0515,"CHUK,INPPL1,ITGA5,MAPK3,RAC1,TGFBR2,YWHAH"]
["CD27 Signaling in Lymphocytes",1.6,0.0755,"CHUK,MAP2K4,Map3k7,NFKBIA"]
["Neuroinflammation Signaling Pathway",1.6,0.04,"CD200,CHUK,CTNNB1,CXCL12,CYBB,IDE,IRAK2,MAP2K4,MAPK3,NFATC3,PPP3R1,TGFBR2"]
["Phospholipase C Signaling",1.59,0.0414,"Calm1 (includes others),Cdc42,EP300,ITGA5,MAPK3,MEF2A,MYL12A,NFATC3,PPP3R1,RAC1,RHOA"]
["Iron homeostasis signaling pathway",1.59,0.0511,"ARNT,ATP6AP1,ATP6V1D,FBXL5,LRP1,MAPK3,TFRC"]
["PI3K Signaling in B Lymphocytes",1.57,0.0507,"Calm1 (includes others),CHUK,MAPK3,NFATC3,NFKBIA,PPP3R1,RAC1"]
["Granulocyte Adhesion and Diapedesis",1.52,0.0462,"CXCL12,EZR,GNAI2,GNAI3,MSN,PECAM1,Ppbp,RDX"]
["G-Protein Coupled Receptor Signaling",1.51,0.0401,"CHUK,DUSP1,DUSP6,GNAI2,GNAI3,MAPK3,NFKBIA,PDE1B,PDE2A,PRKAR1A,S1PR1"]
["Systemic Lupus Erythematosus In B Cell Signaling Pathway",1.5,0.04,"Calm1 (includes others),CSK,CTNNB1,INPPL1,MAPK3,MCL1,NFATC3,PPP3R1,RAC1,SHC2,TRAF1"]
["Aryl Hydrocarbon Receptor Signaling",1.5,0.049,"ALDH18A1,ARNT,EP300,GSTZ1,MAPK3,PTGES3,RARG"]
["NGF Signaling",1.48,0.0526,"CHUK,MAP2K4,Map3k7,MAPK3,RAC1,RHOA"]
["Xenobiotic Metabolism AHR Signaling Pathway",1.48,0.0588,"ALDH18A1,ARNT,EP300,GSTZ1,PTGES3"]
["Inhibition of Angiogenesis by TSP1",1.47,0.0882,"MAP2K4,TGFBR2,THBS1"]
["AMPK Signaling",1.44,0.0423,"ACTB,AKT1S1,ARID1A,EP300,GYS1,PRKAR1A,RAB7A,SMARCD1,SMARCD2"]
["TWEAK Signaling",1.44,0.0857,"CHUK,NFKBIA,TRAF1"]
["PCP pathway",1.43,0.0667,"MAP2K4,PFN1,RAC1,RHOA"]
["Role of PKR in Interferon Induction and Antiviral Response",1.42,0.0508,"CHUK,HSPA4,MAP2K4,MAPK3,NFKBIA,TAB2"]
["Renin-Angiotensin Signaling",1.42,0.0508,"MAP2K4,MAPK3,PAK1,PRKAR1A,RAC1,SHC2"]
["IL-17A Signaling in Fibroblasts",1.4,0.0833,"CHUK,MAPK3,NFKBIA"]
["Acute Myeloid Leukemia Signaling",1.4,0.0562,"CEBPA,IDH3B,MAP2K4,MAPK3,RUNX1"]
["Relaxin Signaling",1.39,0.0464,"GNAI2,GNAI3,MAPK3,NFKBIA,PDE1B,PDE2A,PRKAR1A"]
["L-DOPA Degradation",1.38,0.5,"COMT"]
["Role of PI3K/AKT Signaling in the Pathogenesis of Influenza",1.34,0.0625,"GNAI2,GNAI3,MAPK3,NFKBIA"]
["Regulation Of The Epithelial Mesenchymal Transition By Growth Factors Pathway",1.34,0.0426,"CHUK,ETS1,MAP2K4,MAPK3,RAC1,RHOA,SNAI2,TGFBR2"]
["IL-17A Signaling in Airway Cells",1.32,0.0615,"CHUK,MAP2K4,MAPK3,NFKBIA"]
["Netrin Signaling",1.32,0.0615,"NFATC3,PPP3R1,PRKAR1A,RAC1"]
["D-myo-inositol-5-phosphate Metabolism",1.32,0.0446,"ALPL,CA3,DUSP1,NUDT4,PGAM5,PIP4P1,PPFIA1"]
["D-myo-inositol (1,4,5)-trisphosphate Degradation",1.31,0.118,"INPP5A,INPPL1"]
["Calcium-induced T Lymphocyte Apoptosis",1.3,0.0606,"Calm1 (includes others),CAPN2,EP300,PPP3R1"]
["Pyridoxal 5'-phosphate Salvage Pathway",1.3,0.0606,"CDK8,MAP2K4,MAPK3,PAK1"]
["IL-6 Signaling",1.3,0.0476,"CHUK,MAP2K4,MAPK3,MCL1,NFKBIA,SRF"]