{"text_format":"3","workbook":"xls","n_sheets":1,"sheets":["Sheet0"],"not_rendered":{"external_links":1},"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Sheet0","index":0,"n_rows":27,"n_cols":5,"rows_kept":27,"flags":["formulas_cached_only"]}
["Table S13. Ingenuity Pathway Analysis (IPA)-top functions and diseases enriched for transcripts that display significant 3' UTR shortening at day 21 as compared to day 14 post-fracture "]
["ID","Molecules in Network","Score","Focus Molecules","Top Diseases and Functions"]
[1,"AChR,AMPD2,Betacatenin/TCF,calpain,CAPN2,CAPNS1,CAST,CDYL,CSDE1,CSF,CTBP1,CTNNB1,Cux1,Ewsr1,FERMT2,GOLGA7,IDH3A,IDH3B,KANK1,MLX,MPEG1,PABPC1,PDE4DIP,PHF20L1,PHLDB2,PRDM2,PYGO2,RAB32,RNF111,SNAP23,Spectrin,TAX1BP3,TLN1,ZDHHC5,ZFR",50,30,"[Carbohydrate Metabolism, Nucleic Acid Metabolism, Small Molecule Biochemistry]"]
[2,"AQP1,ATPAF2,caspase,CBFB,COMMD3-BMI1,creatine kinase,EIF1AX,FBXO28,FKBP4,GATAD1,GATAD2A,GPKOW,Hsp27,Hsp70,HSPA4,IBTK,KIF5B,KLF6,LAMP2,LAMTOR5,LBR,MTA2,NFkB (family),NFKBIA,PFN1,PTGES3,RARG,RUNX1,SPRYD3,SQSTM1,TFG,TNRC18,TRAF1,TRIM23,USP11",50,30,"[Dermatological Diseases and Conditions, Hair and Skin Development and Function, Organismal Development]"]
[3,"ACTR1A,alcohol group acceptor phosphotransferase,CAPZA1,CAPZA2,CDC23,CDK8,CFAP36,DDX3X,DDX5,Erm,EZR-MSN-RDX,GORASP2,GSTZ1,INPP5A,MED13L,MED16,mediator,MIS18A,Mlcp,MPHOSPH6,MRFAP1,PCDH7,PLEK,PRPS1,RAC1,RCSD1,RDX,ROCK,THRAP3,TRAP/Media,TUT7,TXLNA,TXN2,UBL3,XPNPEP1",45,28,"[Cell Signaling, Post-Translational Modification, Protein Synthesis]"]
[4,"ANKRD28,ANXA5,ARCN1,ATP2B1,BZW1,COPA,ENaC,HECTD1,IRAG2,KIAA0232,LYPLA1,Ngf,Nos,peroxidase (miscellaneous),PICALM,RAS,SDHA,SEC22B,Secretase gamma,SERPINE2,SLC1A5,SLC35C2,SLC35E1,SLC38A2,SPPL3,STX12,TAPT1,TMED2,TMEM131,TMEM209,TTC17,tyrosine kinase,UNC93B1,VDAC1,WNK1",45,28,"[Amino Acid Metabolism, Molecular Transport, Small Molecule Biochemistry]"]
[5,"ALPL,APOBEC1,apyrase,CA3,Calcineurin A,Calcineurin protein(s),CANT1,ENDOD1,FKBP10,FUBP3,HNRNPA0,HS2ST1,JDP2,KIF13A,LDL-cholesterol,MEF2A,MSN,N-Cadherin,Nfat (family),NFATC3,NKTR,NUDT4,P38 MAPK,peptidylprolyl isomerase,PGAM5,phosphatase,PPFIA1,PPP3R1,RAB10,RABGAP1L,RGL2,SAMD1,TBC1D23,TOR1AIP2,ZFYVE26",40,26,"[Cell Cycle, Cellular Growth and Proliferation, Cellular Movement]"]
[6,"AGFG2,BTAF1,BTF3,Cbp/p300,CDV3,CEP85,CPSF7,DKC1,Ecm,EGLN,EGLN2,EIF5A,EMP1,GAK,HEATR3,Holo RNA polymerase II,Integrin alpha 3 beta 1,LUC7L2,NELFA,Nptn,PARP,PMP22,Rnr,SARS2,SMAD1/5/9,SRPRA,SRSF10,SRSF6,SSR2,TCOF1,TOP1,TRIB2,U2AF2,UHRF2,Vegf",40,26,"[Cellular Function and Maintenance, Molecular Transport, RNA Trafficking]"]
[7,"14-3-3,ACP2,ACSL1,ACTN4,ACTR2,AGPAT1,ATP synthase,CG,DAZAP2,DHRS3,DUSP1,DUSP6,FAM168B,FSH,GNAI2,GNAI3,Lh,MAP2K1/2,MAPK3,MCL1,NFYA,Notch,Pdlim3,PEPCK,PLXND1,PTP4A1,RBAK,somatostatin receptor,SP3,SPTBN1,UBL4A,UFD1,VCL,VEZF1,YBX3",40,26,"[Cardiovascular Disease, Cardiovascular System Development and Function, Organ Morphology]"]
[8,"ACSF2,ACTB,Actin,ADAM10,Adaptor protein 2,AGRN,ANKS1A,ASPH,Calm1 (includes others),Calmodulin,CD44,Cdc42,Clathrin,EPB41,EZR,Fgf,GLRX5,HSPD1,ISCA1,KPNA4,MAP2K4,Metalloprotease,MRPL10,MYH9,PAFAH1B2,PAK1,Proinsulin,Ras homolog,RPL7L1,SNW1,SRP72,SYF2,TCR,YWHAH,YWHAZ",40,26,"[Cell Morphology, Cellular Assembly and Organization, Cellular Function and Maintenance]"]
[9,"ABCD1,AKT1S1,ATP6AP1,ATP6V1D,B3GNT2,BRD3,Dynein,EIF4B,ERK1/2,GPC1,KIAA0100,LYST,MTORC1,MTORC2,MTSS1,NEURL4,OAZ1,OSBPL11,OSBPL1A,PIP4P1,PRIMPOL,Rab5,RAB5A,RAB5B,RAB5C,RAB7,RAB7A,Rho gdi,Rsk,RSPRY1,S6K1,SEMA3F,SUN2,Vacuolar H  ATPase,VAPA",38,25,"[Cell Morphology, Cell-To-Cell Signaling and Interaction, Cellular Assembly and Organization]"]
[10,"ACVRL1,ARHGDIB,ATG4A,BNIP3L,CD200,Cd24a,CD3 group,CLEC7A,EIF2AK1,FBXL5,GABA-A receptor,GABARAP,GTF3C2,hemoglobin,Hif,IKKA/B,JUN/JUNB/JUND,LUC7L3,Lymphotoxin,MAP1LC3,MAP7D1,NFkB (complex),SGCB,SLC16A3,SMAD1/5,SULF2,T3-TR-RXR,TFRC,TNFRSF19,UBE2,UBE2Q2,Vla-4,VPS54,ZFAND6,ZFYVE1",32,22,"[Cellular Function and Maintenance, Hematological System Development and Function, Molecular Transport]"]
[11,"ALDH18A1,Ap1,ARNT,CD3,CDC42EP3,CEBPA,CHCHD4,Ck2,Creb,CTCF,cytochrome C,cytochrome-c oxidase,EP300,ERG,estrogen receptor,H1-0,Histone h3,HNRNPUL1,Hsp90,MATR3,MAX,P-TEFb,PI3K p85,PSMD7,RAD21,RBM28,RNA polymerase II,RSL1D1,SNAI2,SNX4,SPEG,SRC (family),TGFBR2,thymidine kinase,TSPAN7",29,21,"[Connective Tissue Development and Function, Embryonic Development, Organ Development]"]
[12,"ADI1,AKIRIN1,ANKH,C6orf62,CABLES2,CCNI,CDKN1A,Cops2,CSAD,ELAVL1,FAM76B,FBXO4,FSTL3,GPCPD1,GPR83,HNRNPL,ITCH,KDM4D,MCM2,MFAP4,MKI67,MPZL2,MT1L,MYBPH,Ptms,RHBDL2,SERINC5,SETD5,SLC25A13,SMARCA4,SMARCA5,TMEM127,TP53,TRIM65,TWIST",27,20,"[Cancer, Cell Cycle, Organismal Injury and Abnormalities]"]
[13,"ASAH1,BCR (complex),c-Src,CA2,Caveolin,CDO1,CSF1,CSK,Dynamin,Efna,Fibrinogen,FRYL,GSR,INPPL1,IRAK2,ITGA5,Laminin (family),Mapk,Pdgf (complex),PDGF BB,PI3K (family),PLA2,PLC gamma,RFNG,RNF166,Shc,SHC2,Smad,SMAP2,Sos,SOST,TIMM17A,TNKS2,YTHDF1,ZNF705A",26,19,"[Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Immune Cell Trafficking]"]
[14,"ADD1,ADK,Akt,Alpha actin,Alpha Actinin,Arp2/3,Cald1,CAP1,Cebp,Cofilin,Collagen type VI,Diap,F Actin,Fascin,Foxo,G-Actin,Integrinβ,LAPTM4B,MYO18A,PALM,Profilin,RAB35,RNF144A,SEMA6D,SGMS2,SORBS2,SRF,Talin,TMOD3,Tpm4,Tropomyosin,Troponin t,TSPAN13,UBXN2A,WDR1",24,18,"[Cell Morphology, Cellular Assembly and Organization, Cellular Function and Maintenance]"]
[15,"BTG3,COL10A1,Collagen type I (complex),Collagen type III,Collagen type IV,Collagen(s),collagenase,COMT,Cr3,DMP1,ELF1,Eotaxin,ERK,ETS,ETS1,F13A1,Fc gamma receptor,FLI1,GPIIB-IIIA,IL10RB,Integrin alpha V beta 3,ITGA10,Laminin1,LRRFIP1,LUM,NCLN,NOMO1 (includes others),Osteocalcin,SH2B3,Smad2/3,SYK/ZAP,TCF20,THEMIS2,TNC,VAV",24,18,"[Developmental Disorder, Hereditary Disorder, Tissue Development]"]
[16,"ACSS2,ACTL6A,APC/APC2,ARID1A,ATRX,BAZ2A,Caspase 3/7,Dishevelled,EPC1,Fc receptor,FCER2,GC-GCR dimer,GLYR1,HABP4,Hdac1/2,HISTONE,Histone h2a,Histone H2b,Histone h4,IgG2b,Importin alpha,Importin beta,ING1,IPO9,MEN1,Par6,Pkc(s),RNF20,Rxr,SMARCD1,SMARCD2,SS18,SWI-SNF,TIP60,TXNDC5",22,17,"[Cell Cycle, Cellular Assembly and Organization, DNA Replication, Recombination, and Repair]"]
[17,"20s proteasome,26s Proteasome,ACLY,Alpha tubulin,ATPase,CHMP5,CHUK,Cyclin E,DNA2,E2f,GOT,HCFC1,Hdac,HDL-cholesterol,HELB,IDE,Insulin,LDLR,MHC CLASS I (family),N-cor,NIPSNAP2,Nr1h,P glycoprotein,p70 S6k,PCYT1A,PRKAA,Rb,SCD,SHISA5,SIRT2,TRIM35,TUBB,Ubiquitin,VBP1,VPS4A",22,17,"[Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry]"]
[18,"ABHD17C,Arf2,ARMC1,ATXN3,BRSK2,CAPN15,CEMIP,COMMD1,COMMD10,DNAJC6,H2AC7,HNRNPA2B1,HYAL1,IDH3B,KCTD20,LSM12,LSM14B,MAPT,Mbp,MEPCE,MTFR1L,NHSL1,OTUD3,PHACTR2,R3HDM4,RNF220,SART1,SLC6A1,SOCS5,STARD9,TMCO6,TRIM25,UBC,WDR1,Zranb2",17,14,"[Cell Morphology, Nervous System Development and Function, Neurological Disease]"]
[19,"ANKH,AP1S1,C/EBP,CAMLG,Ctbp,E1,Ephb,Fcer1,FTO,GIT2,growth factor,GUSB,H/K/NRAS,HMG CoA synthase,Ikb,Ikk (family),IL-1R,IRAK,Jnk,MAP3K,Map3k7,myosin-light-chain kinase,NCK,NFAT (complex),Pak,Pias,PIAS3,SAE1,Srebp,TAB2,TCF,VLDL,WIPF1,ZKSCAN3,ZMIZ2",15,13,"[Cell Death and Survival, Hematological System Development and Function, Humoral Immune Response]"]
[20,"Alpha catenin,APC (complex),Atrial Natriuretic Peptide,Cadherin,CaMKII,cAMP-dependent protein kinase,Cdc2,Cdk,COL6A1,COL6A3,CTDSP1,Cyclin A,Filamin,GDA,Glycogen synthase,Growth hormone,GYS1,Histone H1,JAK1/2,LMO7,LTBP2,MEF2,MHC Class II (complex),MIR124,OSTC,Pde,PDE1B,PDE2A,PI3K (complex),Pka catalytic subunit,PP1 protein complex group,PVALB,RASA3,RNF187,thyroid hormone receptor",15,13,"[Connective Tissue Disorders, Developmental Disorder, Hereditary Disorder]"]
[21,"ADRB,AMPK,ARFIP1,ARHGAP29,ARL1,BETA TUBULIN,C1q,G protein alpha,G protein alphai,G protein beta gamma,G-protein beta,Gpcr,GTPase,Gαi/o,Gαq,HDL,KCTD18,LDL,LIMS1,LRP1,MYO9A,NADPH oxidase,PLC,Pld,Rab11,Rac,Raf,RHOA,RTL8B,S1PR1,Sapk,Sfk,Sphk,TSPAN31,tubulin",12,11,"[Cell-To-Cell Signaling and Interaction, Cellular Assembly and Organization, Cellular Function and Maintenance]"]
[22,"ADCY,AGT,AHCYL1,APP,CAP1,COL4A6,CRYM,DEFA6,DUS3L,F2RL1,FGF2,FIBIN,ganglioside GT1,GPR12,GPR4,HTR1E,hydrogen peroxide,Inflammasome (Nalp3, Asc, Casp1),Mmp,MPV17,Na-k-atpase,NDP,Nrgn,OSM,P2RY11,PKIG,Ppp1r12a,Ptma (includes others),REG3A,SH3BGRL3,SLC39A13,Syntaxin,TMEM183A,trypsin,ZNF263",12,11,"[Cardiovascular System Development and Function, Cellular Development, Cellular Function and Maintenance]"]
[23,"atypical protein kinase C,COL12A1,COL24A1,COLGALT1,collagen,Collagen Alpha1,collagen type i (family),Gef,Hif1,IFN alpha/beta,Integrin,Integrin alpha 5 beta 1,ITPR,JINK1/2,L-type Calcium Channel,Laminin (complex),Ldh (complex),Lfa-1,Mlc,MYL12A,PJA2,Pka,Pkg,PP2A,Ppp2c,PRKAR1A,PTK,PTPase,Rap1,Rar,Sp100,STK24,STRN4,THBS1,Wnt",10,10,"[Cancer, Connective Tissue Disorders, Organismal Injury and Abnormalities]"]
[24,"Alp,BCL6,chemokine,CXCL12,CYBB,cytokine,HDGF,HSP,Ifn,IFN Beta,Ifn gamma,IFN type 1,Ifnar,Iga,Ige,IGFBP4,IgG,IgG1,IgG2a,Igg3,Igm,IL1,IL12 (complex),IL12 (family),Immunoglobulin,Interferon alpha,MDFIC,PECAM1,Ppbp,SAMHD1,SETD3,STAT5a/b,Tgf beta,Tlr,Tnf (family)",10,10,"[Cellular Function and Maintenance, Cellular Movement, Hematological System Development and Function]"]
[25,"AOC1,C2orf42,CSF2,Dazap1,DDX49,DSC2,FAM76A,Focal adhesion kinase,FOXP3,GNRH,Gsk3,GUSB,HNF4A,hydrochloric acid,IKK (complex),JKAMP,KLRC4-KLRK1/KLRK1,LAD1,LAX1,LOC102724788/PRODH,Lpa receptor,LTBP2,Mek,NEK7,p85 (pik3r),Pdgfr,PPIP5K2,SCIMP,SLC16A6,Slco1a1,STAT,TEC/BTK/ITK/TXK/BMX,TNF,ZBTB11,Zc3h15",7,8,"[Cell-To-Cell Signaling and Interaction, Infectious Diseases, Tissue Development]"]